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Sample records for st acton ma

  1. ACTON - AUTOCAD TO NASTRAN TRANSLATOR

    Science.gov (United States)

    Jones, A.

    1994-01-01

    The AutoCAD to NASTRAN translator, ACTON, was developed to facilitate quick generation of small finite element models for use with the NASTRAN finite element modeling program. (NASTRAN is available from COSMIC.) ACTON reads the geometric data of a drawing from the Data Exchange File (DXF) used in AutoCAD and other PC based drafting programs. The geometric entities recognized by ACTON include POINTs, LINEs, SOLIDs, 3DLINEs and 3DFACEs. From this information ACTON creates a NASTRAN bulk data deck which can be used to create a finite element model. The NASTRAN elements created include CBARs, CTRIAs, CQUAD4s, CPENTAs, and CHEXAs. The bulk data deck can be used to create a full NASTRAN deck. It is assumed that the user has at least a working knowledge of AutoCAD and NASTRAN. ACTON was written in Microsoft QuickBasic (Version 2.0). The program was developed for the IBM PC and has been implemented on an IBM PC compatible under DOS 3.21. ACTON was developed in 1988.

  2. Summary of ST-MA deliverables for LHC

    CERN Document Server

    Cennini, E; Ninin, P; Nunes, R; Scibile, L; CERN. Geneva. ST Division

    2003-01-01

    The ST/MA group is responsible for the monitoring of the CERN Technical Infrastructure as well as the design, installation and maintenance of personnel protection system such as access control system, fire and gas leak detection, safety alarm monitoring systems and radiation monitoring systems (in collaboration with TIS). This paper provides an overview of the main projects and services managed in the group and outlines the scope, the organisation and the planning of the main deliverables for LHC.

  3. "Vernonia School District v. Acton": Suspicionless Drug Testing.

    Science.gov (United States)

    Rossow, Lawrence F.; Stefkovich, Jacqueline

    1996-01-01

    In "Acton," the Supreme Court upheld a local school board policy calling for the random, suspicionless drug testing of interscholastic student athletes. The Supreme Court reasoned that student athletes have a low expectation of privacy; the scope of the search was relatively unobtrusive; and the program served an important government…

  4. Ma

    Directory of Open Access Journals (Sweden)

    Ingrid Berthon-Moine

    2012-01-01

    Full Text Available Ma (2009 is a single channel video of a mother and child walking together side by side, holding hands. The title is reminiscent of the affectionate nickname for a mother, 'Ma', but also a concealed way to convey maternal ambivalence. Maternal ambivalence is the result of the tension between the idealisation of motherhood and women’s lived experience of mothering. The maternal struggle finds its source in the difficulty of identifying with the ideological representation of the mother. This image still conveys an idealistic and nostalgic, patriarchal image of maternal love bounded by culture and history. http://podcast.ulcc.ac.uk/accounts/BirkbeckCollege/mamsie/MA.mov

  5. A project by the SIDeMaST Immunopathology Group on cutaneous vasculitis.

    Science.gov (United States)

    Papini, M; Quaglino, P; La Placa, M; Marzano, A V

    2015-04-01

    Vasculitides are a challenge to the clinician, in terms of both diagnosis and therapy. Multiple classification systems have been implemented and the numerous classification schemes reflect the complexity of establishing a simple classification that could be functional for daily care. Although vasculitis classification has become increasingly elaborated, some areas remain ill defined. Some forms of vasculitis are still difficult to assign to a specific disease entity. Generally accepted operational criteria are available for many vasculitides, but for some entities there are no effective criteria. Moreover, diagnostic criteria for vasculitis with sufficient strength and/or confidence that can be universally accepted are not yet available. The need for diagnostic criteria validated and agreed upon is particularly relevant in the context of cutaneous vasculitis. The project of the SIDeMaST Italian Group of Immunopathology on cutaneous vasculitis is a national prospective observational study designed to develop and validate diagnostic criteria and to improve and validate classification criteria for cutaneous small vessel vasculitis also known as leukocytoclastic vasculitis (CLV). Primary objective of the study will also be that of developing the CUtaneous VAsculitis Severity Index (CUVASI). Secondary objectives of the project will be: 1) definition of the etiological agents that are most frequently associated with CLV; 2) search for possible correlations between causative agent and peculiar clinical and/or histopathological aspects; 3) evaluation of immunofluorescence pattern observed in this specific group of primitive cutaneous vasculitis in order to characterize the diagnostic sensitivity and specificity of this technique; 4) identification of a set of clinical investigations and laboratory tests to be performed for a correct CLV assessment. Actually 15 Italian dermatological clinics are contributing to the project and anticipated recruiting >100 patients with CLV

  6. Üstün Yetenekli Dijital Yerlilerin Sosyal Medya Kullanımları Üzerine Nitel Bir Çalışma

    Directory of Open Access Journals (Sweden)

    İbrahim Şamil Köroğlu

    2015-08-01

    Full Text Available Ağ neslinin yeni medya teknolojilerine ilişkin algısına ve teknolojiyi kullanma motivasyonuna ilişkin yapılan nicel çalışmalar dijital antropoloji alanına ilgi duyanlar için ufuk açıcı niteliktedir. Ağ neslinin özellikli bir grubunu teşkil eden üstün yetenekli dijital yerliler ise interneti ve mobil iletişim teknolojilerini bir dil gibi kullanabilen, içerik üretimi ve paylaşımı konusunda katılımcı, bilgi edinme, eğlenme ve sosyalleşme amacıyla birincil kaynak olarak sanal ortamı gören üstün yetenekli çocuklardır. Üstün yetenekli dijital yerlilerin sosyal medya kullanım motivasyonlarını Kullanımlar ve Doyumlar Yaklaşımı ile inceleyen bu çalışma, betimsel nitelikli tarama modelinde bir araştırmadır. Araştırma grubu, 2012-2013 eğitim yılında İstanbul Bilim ve Sanat Merkezi, Beşiktaş Bilim ve Sanat Merkezi ve Beyazıt Ford Otosan İlköğretim Okulu’nda öğrenim gören 401 üstün yetenekli öğrencidir. Grupta yer alan üstün yeteneklilerin 231’i (%57,6 9–11; 148’i (%36,9 12–14; 22’si (%5,5 ise 15–17 yaş grubundadır. Araştırmaya katılan üstün yeteneklilerin 247’si erkek (%61,6; 154’ü (%38,4 kız öğrencilerden oluşmaktadır. Çalışmada üstün yetenekli dijital yerlilerin sosyal medya kullanım sıklıkları; internet kullanım amaçları ile sosyal medya kullanım amaçları ve sık kullandıkları sosyal medya sitelerinin hangileri olduğu incelenmiştir. Çalışmada elde edilen bulgular üstün yetenekli dijital yerlilerin sosyal medya kullanım sıklığının akranlarına oranla Türkiye ortalamasının altında kaldığını; internet kullanım amaçlarıyla sosyal medya kullanım amaçlarının örtüştüğünü, ayrıca YouTube, Facebook ve Twitter’ın üstün yetenekli dijital yerlilerin en sık kullandıkları sosyal medya siteleri olduğunu ortaya koymaktadır.

  7. Novel composite sorbent AAm/MA hydrogels containing starch and ...

    Indian Academy of Sciences (India)

    ethylene glycol)diacrylate as a crosslinker. Surface ...... Partition coefficients of TB between dye solution and AAm/MA, AAm/MA/St,. AAm/MA/K and AAm/MA/St/K hydrogel systems contain- ing 60 mg MA and 1·0% K were calculated, and are shown.

  8. Zhigang Ma

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Zhigang Ma. Articles written in Bulletin of Materials Science. Volume 35 Issue 4 August 2012 pp 575-578. Degradation and miscibility of poly(DL-lactic acid)/poly(glycolic acid) composite films: Effect of poly(DL-lactic-co-glycolic acid) · Zhigang Ma Na Zhao Chengdong Xiong.

  9. JU-MING MA

    Indian Academy of Sciences (India)

    JU-MING MA. Articles written in Journal of Biosciences. Volume 42 Issue 2 June 2017 pp 209-218 Article. Genetic diagnosis of a Chinese multiple endocrine neoplasia type 2A family through whole genome sequencing · ZHEN-FANG DU PENG-FEI LI JIAN-QIANG ZHAO ZHI-LIE CAO FENG LI JU-MING MA XIAO-PING QI.

  10. [MaRS Project

    Science.gov (United States)

    Aruljothi, Arunvenkatesh

    2016-01-01

    The Space Exploration Division of the Safety and Mission Assurances Directorate is responsible for reducing the risk to Human Space Flight Programs by providing system safety, reliability, and risk analysis. The Risk & Reliability Analysis branch plays a part in this by utilizing Probabilistic Risk Assessment (PRA) and Reliability and Maintainability (R&M) tools to identify possible types of failure and effective solutions. A continuous effort of this branch is MaRS, or Mass and Reliability System, a tool that was the focus of this internship. Future long duration space missions will have to find a balance between the mass and reliability of their spare parts. They will be unable take spares of everything and will have to determine what is most likely to require maintenance and spares. Currently there is no database that combines mass and reliability data of low level space-grade components. MaRS aims to be the first database to do this. The data in MaRS will be based on the hardware flown on the International Space Stations (ISS). The components on the ISS have a long history and are well documented, making them the perfect source. Currently, MaRS is a functioning excel workbook database; the backend is complete and only requires optimization. MaRS has been populated with all the assemblies and their components that are used on the ISS; the failures of these components are updated regularly. This project was a continuation on the efforts of previous intern groups. Once complete, R&M engineers working on future space flight missions will be able to quickly access failure and mass data on assemblies and components, allowing them to make important decisions and tradeoffs.

  11. Ma(d)skulinitet

    DEFF Research Database (Denmark)

    Leer, Jonatan

    Når tv-kokke som Jamie Oliver, Gordon Ramsay og brødrene Price toner frem på skærmen, laver de ikke kun mad. De mixer også maskulinitet. For når en mand laver mad, laver maden også manden. Det mener postdoc Jonatan Leer, der i Ma(ds)kulinitet. Kønskamp i tv-køkkenet præsenterer, hvordan og hvorfor...

  12. MaTeam-projektet

    DEFF Research Database (Denmark)

    Andreasen, Marikka; Damkjær, Helle Sejer; Højgaard, Tomas

    2011-01-01

    Projektet MaTeam beskrives med fokus på et toårigt forsøg hvor matematiklærerne på 4.-6. klassetrin på fire skoler i Silkeborg Kommune samarbejdede med forfatterne. Projektet handlede om udvikling af matematiklærerkompetencer med fokus på samarbejdet i de fire skolers matematiklærerfagteam. Hoved...

  13. ST Safety What's on?

    CERN Document Server

    Jacot, C

    2001-01-01

    Du premier coup de pioche jusqu'à la mise en place de la tente abritant le buffet offert lors de la cérémonie d'achèvement d'un projet, la division ST est sur les rangs et apporte son savoir faire. Ces projets nombreux et pluridisciplinaires sont étudiés, se réalisent, s'exploitent et font l'objet de maintenance jusqu'à leur démantèlement. Durant leurs cycles de vie, la division ST avance les compétences professionnelles spécifiques à chaque corps de métiers incluant le recours à de nombreux contrats avec des entreprises extérieures pour réaliser les travaux sur les sites du CERN. Pour en conserver la maîtrise, la division ST applique une gestion de projet, une assurance de la qualité et s'attache tout particulièrement à la sécurité, à la réglementation, à la prévention des risques et la gestion de ceux-ci. Sous la supervision du DSO, un ensemble de procédures et de démarches a été développé afin de faciliter les tâches du maître d'ouvrage et des entreprises contractantes, c...

  14. Millennium Ecosystem Assessment: MA Biodiversity

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Biodiversity provides data and information on amphibians, disease agents (extent and distribution of infectious and parasitic...

  15. Millennium Ecosystem Assessment: MA Ecosystems

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Ecosystems provides data and information on the extent and classification of ecosystems circa 2000, including coastal,...

  16. Millennium Ecosystem Assessment: MA Scenarios

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Scenarios provide useful insight into the complex factors that drive ecosystem change, estimating the magnitude of regional...

  17. Discovery and utilization of sorghum genes (Ma5/Ma6)

    Science.gov (United States)

    Mullet, John E; Rooney, William L; Klein, Patricia E; Morishige, Daryl; Murphy, Rebecca; Brady, Jeff A

    2012-11-13

    Methods and composition for the production of non-flowering or late flowering sorghum hybrid. For example, in certain aspects methods for use of molecular markers that constitute the Ma5/Ma6 pathway to modulate photoperiod sensitivity are described. The invention allows the production of plants having improved productivity and biomass generation.

  18. Roadmap to MaRIE March 2015

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, Cris William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-03-30

    Los Alamos National Laboratory’s proposed MaRIE facility is slated to introduce the world’s highest energy hard x-ray free electron laser (XFEL). As the light source for the Matter-Radiation Interactions in Extremes experimental facility (MaRIE), the 42-keV XFEL, with bursts of x-ray pulses at gigahertz repetition for studying fast dynamical processes, will help accelerate discovery and design of the advanced materials needed to meet 21st-century national security and energy security challenges. Yet the science of free-electron lasers has a long and distinguished history at Los Alamos National Laboratory (LANL), where for nearly four decades Los Alamos scientists have been performing research, design, development, and collaboration work in FEL science. The work at Los Alamos has evolved from low-gain amplifier and oscillator FEL development to highbrightness photoinjector development, and later, self-amplified spontaneous emission (SASE) and high-gain amplifier FEL development.

  19. Millennium Ecosystem Assessment: MA Population

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Population data sets provide baseline population information as one of the drivers of ecosystem change. The data helped in...

  20. True Polar Wander and Hotspot Fixity: A Paleomagnetic Investigation of the Skewness of Magnetic Anomaly 12r (32 Ma B.P.) on the Pacific Plate

    Science.gov (United States)

    Gordon, R. G.; Horner-Johnson, B. C.

    2010-12-01

    Prior studies have shown that Pacific hotspots and Indo-Atlantic hotspots have moved in approximate unison relative to the spin axis since 65 Ma B.P. [Morgan, 1981; Gordon and Cape, 1981; Gordon, 1982] and since 56 Ma B.P. [Petronotis et al., 1994], which is most simply interpreted as true polar wander. In contrast, Pacific hotspots and Indo-Atlantic hotspots give conflicting results for 72 Ma B.P. and for 81 Ma B.P., which may indicate motion between Pacific hotspots and Indo-Atlantic hotspots [Tarduno and Cottrell, 1997; Petronotis et al., 1999; Tarduno et al., 2003]. Thus it is important to estimate Pacific plate apparent polar wander (APW) for more time intervals. From such estimates the APW of Pacific hotspots can be inferred and compared with that of Indo-Atlantic hotspots [e.g., Besse and Courtillot 2002]. Here we present a study of the skewness of anomaly 12r between the Galapagos and Clipperton and between the Clipperton and Clarion fracture zones. We chose this region for several reasons: First, numerical experiments, like those conducted by Acton and Gordon [1991], indicate that magnetic profiles between the Galapagos and Clarion fracture zones should contain the most information about the Pacific plate paleomagnetic pole for chron C12r (32 Ma B.P.). Second, in these two spreading rate corridors, spreading half rates range from 72 to 86 mm/a and therefore have negligible anomalous skewness, given that they exceed ≈50 mm/a [Roest et al., 1992; Dyment et al. 1994]. Third, vector aeromagnetic profiles are available for analysis. One of the challenges to interpreting magnetic anomalies in low latitudes where the anomalies strike nearly north-south is the very low amplitude of the signal relative to the noise, the latter of which can be especially intense near the present magnetic equator due to the amplification of diurnal variation by the equatorial electrojet. Previously we showed that vector aeromagnetic profiles record low-latitude Pacific plate

  1. St. Lucia.

    Science.gov (United States)

    1987-06-01

    The population of St Lucia was 123,000 in 1986, with an annual growth rate of 2%. The infant mortality rate stands at 22.2/1000 live births, and life expectancy is 70.3 years for males and 74.9 years for females. The literacy rate is 78%. St Lucia's labor force is allocated as follows: agriculture, 36.6%; industry and commerce, 20.1%; and services, 18.1%. The gross national product (GNP) was US$146 million in 1985, with an annual growth rate of 3% and a per capita GNP of $1071. St Lucia is a parliamentary democracy modeled on the British Westminster system. The island is divided into 16 parishes and 1 urban area (the capital, Castries). St Lucia is currently a politically stable country, although the high level of youth unemployment is a cause for concern. Ongoing stability may depend on the government's ability to provide services such as jobs and housing. The economy has evolved from a monocrop sugar plantation type to a diversified economy based on agriculture, industry, and tourism. Agriculture, dominated by the banana industry, is characterized by the participation of a large number of small and medium-sized enterprises. Industry is being encouraged through the provision of incentives such as tax rebates. The government is attempting to maintain a sound investment climate through a tripartite dialogue with the private sector and trade unions. Overall economic policy is predicated on the attraction of sound investments, by both local and foreign entities, to accelerate the rate of economic growth, solve the unemployment problem, and generate a solid balance-of-payments position.

  2. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Science.gov (United States)

    2010-10-01

    ... qualifying MA-affiliated eligible hospitals under the MA EHR incentive program are required to identify...-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare...

  3. Flux consumption optimization and the achievement of 1 MA discharges on NSTX

    International Nuclear Information System (INIS)

    Menard, J.; LeBlanc, B.; Sabbagh, S.A.

    2001-01-01

    The spherical tokamak (ST), because of its slender central column, has very limited volt-second capability relative to a standard aspect ratio tokamak of similar plasma cross-section. Recent experiments on the National Spherical Torus Experiment (NSTX) have begun to quantify and optimize the ohmic current drive efficiency in a MA-class ST device. Sustainable ramp-rates in excess of 5MA/sec during the current rise phase have been achieved on NSTX, while faster ramps generate significant MHD activity. Discharges with I P exceeding 1MA have been achieved in NSTX with nominal parameters: aspect ratio A=1.3-1.4, elongation κ=2-2.2, triangularity δ=0.4, internal inductance l i =0.6, and Ejima coefficient C E =0.35. Flux consumption efficiency results, performance improvements associated with first boronization, and comparisons to neoclassical resistivity are described. (author)

  4. Anti-Ma and anti-Ma2-associated paraneoplastic neurological syndromes.

    Science.gov (United States)

    Ortega Suero, G; Sola-Valls, N; Escudero, D; Saiz, A; Graus, F

    Analyse the clinical profile, associated tumour types, and response to treatment of paraneoplastic neurological syndromes associated with antibodies against Ma proteins. A retrospective study of patients with antibodies against Ma proteins identified in a neuroimmunology laboratory of reference. Of the 32 patients identified, 20 showed reactivity against Ma2 only (anti-Ma2 antibodies), 11 against Ma1 and Ma2 (anti-Ma antibodies), and 1 with reactivity against Ma1 only (anti-Ma1 antibodies). The most common clinical presentations were limbic encephalopathy, diencephalic dysfunction, or brainstem encephalopathy, frequently appearing as a combination of these features. Three patients had isolated cerebellar dysfunction with anti-Ma antibodies, and 2 exhibited peripheral nervous system syndrome with anti-Ma2 antibodies. Testicular tumours were the most common neoplasms (40%) in the anti-Ma2 cases. In the group associated with anti-Ma1 antibodies, the most common were lung tumours (36%), followed by testicular tumours. All idiopathic cases were reactive to Ma2. The clinical outcome was significantly better in the anti-Ma2 group. The patient with anti-Ma1 presented with limbic encephalitis and brainstem dysfunction associated with lymphoepithelioma of the bladder. Specifically determining the different reactivities of anti-Ma protein antibodies in order to differentiate between Ma1 and Ma2 antibodies is important because anti-Ma2-associated paraneoplastic syndromes have a better outcome. Lastly, this study is the first to confirm that there may be cases that react exclusively to antibodies against Ma1. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  5. Obama vu de ma banlieue.

    Directory of Open Access Journals (Sweden)

    Olga Stanislawska

    2008-12-01

    Full Text Available Une petite brocante est organisée tous les jeudis sur une place proche de la Basilique de Saint-Denis. On y vend des livres, des bibelots, des bijoux fantaisies et des masques africains. L’un des vendeurs a visiblement décidé de bénéficier de l’effet Obama. J’ai pris la photo de ma fenêtre, située au dessus de ce marché. J’ai adoré ce stand, mais ce n’est qu’une fois sur l’écran de mon ordinateur que j’ai vu les petites images Banania... ! Si j’avais su, je serais ...

  6. Consideration of QRS complex in addition to ST-segment abnormalities in the estimated "risk region" during acute anterior myocardial infarction

    DEFF Research Database (Denmark)

    van Hellemond, Irene E. G.; Bouwmeester, Sjoerd; Olson, Charles W.

    2011-01-01

    a falsely low estimated total MaR if determined by using ST segment-based methods. The purpose of this study was to investigate if consideration of the abnormalities in the QRS complex, in addition to those in the ST segment, provides a more accurate estimated total MaR during anterior AMI than...

  7. The stability of myocardial area at risk estimated electrocardiographically in patients with ST elevation myocardial infarction

    DEFF Research Database (Denmark)

    Carlsen, Esben A; Hassell, Mariëlla E C J; van Hellemond, Irene E G

    2014-01-01

    In patients with ST-elevation myocardial infarction (STEMI) the amount of myocardial area at risk (MaR) indicates the maximal potential loss of myocardium if the coronary artery remains occluded. During the time course of infarct evolution ischemic MaR is replaced by necrosis, which results in a ...

  8. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Hull, MA to Race Point, MA. 80... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a... position latitude 42°16.7′ N., longitude 70°52.6′ W., to Race Point on Cape Cod. (b) A line drawn from...

  9. M&A Negotiations and Lawyer Expertise

    NARCIS (Netherlands)

    Karsten, C.; Malmendier, U.; Sautner, Z.

    2013-01-01

    We use proprietary data to look into the "black box" of M&A negotiations and to shed light on the effects of lawyer expertise on M&A contract design, the bargaining process, and acquisition pricing. Measuring the effects of buyer relative to seller lawyer expertise, we document that more expertise

  10. Caractérisation de la mycoflore de grains de maïs ( Zea mays ...

    African Journals Online (AJOL)

    L'objectif général de ce travail est de caractériser la flore fongique des grains de maïs destinés, avec d'autres céréales, à la préparation d'aliments composés pour l'alimentation de la volaille. Les grains de maïs désinfectés à l'alcool ont été semés dans des boîtes de Pétri stériles munies de papier filtre stérilisé et humidifié ...

  11. MaROS Strategic Relay Planning and Coordination Interfaces

    Science.gov (United States)

    Allard, Daniel A.

    2010-01-01

    The Mars Relay Operations Service (MaROS) is designed to provide planning and analysis tools in support of ongoing Mars Network relay operations. Strategic relay planning requires coordination between lander and orbiter mission ground data system (GDS) teams to schedule and execute relay communications passes. MaROS centralizes this process, correlating all data relevant to relay coordination to provide a cohesive picture of the relay state. Service users interact with the system through thin-layer command line and web user interface client applications. Users provide and utilize data such as lander view periods of orbiters, Deep Space Network (DSN) antenna tracks, and reports of relay pass performance. Users upload and download relevant relay data via formally defined and documented file structures including some described in Extensible Markup Language (XML). Clients interface with the system via an http-based Representational State Transfer (ReST) pattern using Javascript Object Notation (JSON) formats. This paper will provide a general overview of the service architecture and detail the software interfaces and considerations for interface design.

  12. Ma olin Saddami poeg / Latif Jahija

    Index Scriptorium Estoniae

    Jahija, Latif

    1995-01-01

    Järg Jan/21.,28. lk. 7,5. L. Jahija sensatsiooniline raamat "Ma olin Saddami poeg", milles ta pajatab kuidas ta a. 1987-1991 oli Iraagi presidendi vanema poja teisik. Lühikokkuvõte sellest jutustusest

  13. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals.

    Science.gov (United States)

    2010-10-01

    ... for MA-EPs and MA-affiliated eligible hospitals. 495.204 Section 495.204 Public Health CENTERS FOR... CERTIFICATION STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to...-EPs and MA-affiliated eligible hospitals. (a) General rule. A qualifying MA organization receives an...

  14. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Ann, MA to Marblehead Neck... SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to... apply on the harbors, bays and inlets on the east coast of Massachusetts from Halibut Point at Cape Ann...

  15. A Multi-Approach Evaluation System (MA-ES) of Organic Rankine Cycles (ORC) used in waste heat utilization

    International Nuclear Information System (INIS)

    Shu, Gequn; Yu, Guopeng; Tian, Hua; Wei, Haiqiao; Liang, Xingyu

    2014-01-01

    Highlights: • The MA-ES provides comprehensive valuations on ORC used for waste heat utilization. • The MA-ES covers energetic, exergetic and economic evaluations of typical ORCs. • The MA-ES is a general assessing method without restriction to specific ORC condition. • Two ORC cases of ICE waste-heat-recovery are exemplified applying the MA-ES. - Abstract: A Multi-Approach Evaluation System (MA-ES) is established in this paper providing comprehensive evaluations on Organic Rankine Cycles (ORC) used for waste heat utilization. The MA-ES covers three main aspects of typical ORC performance: basic evaluations of energy distribution and system efficiency based on the 1st law of thermodynamics; evaluations of exergy distribution and exergy efficiency based on the 2nd law of thermodynamics; economic evaluations based on calculations of equipment capacity, investment and cost recovery. The MA-ES is reasonably organized aiming at providing a general method of ORC performance assessment, without restrictions to system configurations, operation modes, applications, working fluid types, equipment conditions, process parameters and so on. Two ORC cases of internal combustion engines’ (ICEs) waste-heat-recovery are exemplified to illustrate the applications of the evaluation system. The results clearly revealed the performance comparisons among ORC configurations and working fluids referred. The comparisons will provide credible guidance for ORC design, equipment selection and system construction

  16. MaRIE Undulator & XFEL Systems

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Dinh Cong [Los Alamos National Laboratory; Marksteiner, Quinn R. [Los Alamos National Laboratory; Anisimov, Petr Mikhaylovich [Los Alamos National Laboratory; Buechler, Cynthia Eileen [Los Alamos National Laboratory

    2015-03-23

    The 22 slides in this presentation treat the subject under the following headings: MaRIE XFEL Performance Parameters, Input Electron Beam Parameters, Undulator Design, Genesis Simulations, Risks, and Summary It is concluded that time-dependent Genesis simulations show the MaRIE XFEL can deliver the number of photons within the required bandwidth, provided a number of assumptions are met; the highest risks are associated with the electron beam driving the XFEL undulator; and risks associated with the undulator and/or distributed seeding technique may be evaluated or retired by performing early validation experiments.

  17. 70 Ma nonmarine diatoms from northern Mexico

    Science.gov (United States)

    Chacón-Baca, Elizabeth; Beraldi-Campesi, H.; Cevallos-Ferriz, S. R. S.; Knoll, A. H.; Golubic, S.

    2002-03-01

    Carbonaceous cherts of the Tarahumara Formation, exposed near Huepac, Sonora, Mexico, contain abundant diatom frustules occurring as benthic filamentous colonies. Stratigraphic and paleontological observations indicate that Tarahumara sediments accumulated in a nonmarine setting; radiometric ages on encompassing volcanic rocks delimit their depositional age to ca. 70 Ma. Tarahumara fossils therefore extend the paleontological record of nonmarine diatoms from middle Eocene to Late Cretaceous. Preserved populations include forms similar to species of the extant genera Amphora and Melosira, as well as filament-forming araphid pennates comparable to species of Fragilaria and Tabellaria. Tarahumara fossils indicate that by 70 Ma, nonmarine diatoms had achieved considerable environmental as well as taxonomic diversity.

  18. M&A information technology best practices

    CERN Document Server

    Roehl-Anderson, Janice M

    2013-01-01

    Add value to your organization via the mergers & acquisitions IT function  As part of Deloitte Consulting, one of the largest mergers and acquisitions (M&A) consulting practice in the world, author Janice Roehl-Anderson reveals in M&A Information Technology Best Practices how companies can effectively and efficiently address the IT aspects of mergers, acquisitions, and divestitures. Filled with best practices for implementing and maintaining systems, this book helps financial and technology executives in every field to add value to their mergers, acquisitions, and/or divestitures via the IT

  19. Fabrication technology for ODS Alloy MA957

    International Nuclear Information System (INIS)

    ML Hamilton; DS Gelles; RJ Lobsinger; MM Paxton; WF Brown

    2000-01-01

    A successful fabrication schedule has been developed at Carpenter Technology Corporation for the production of MA957 fuel and blanket cladding. Difficulties with gun drilling, plug drawing and recrystallization were overcome to produce a pilot lot of tubing. This report documents the fabrication efforts of two qualified vendors and the support studies performed at WHC to develop the fabrication-schedule

  20. Salatoimikud : ma tahan uskuda / Mart Rummo

    Index Scriptorium Estoniae

    Rummo, Mart

    2008-01-01

    USA sarjale "The X-Files" põhinev teine järjefilm "Salatoimikud: Ma tahan uskuda" ("The X-Files: I Want to Believe") : režissöör Chris Carter : peaosades David Duchovny, Gillian Anderson : Ameerika Ühendriigid - Kanada 2008

  1. Mass and Reliability System (MaRS)

    Science.gov (United States)

    Barnes, Sarah

    2016-01-01

    The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including

  2. Návrh optoelektronického snímače polohy

    OpenAIRE

    Straka, Radomír

    2010-01-01

    Cílem této práce je navrhnout optoelektronický snímač polohy, který by určoval aktuální polohu měřicí linky. Tuto polohu je potřeba určovat velice přesně. Nejdříve je práce směrována na seznámení se snímači polohy, které se používají při automatizaci. Práce studuje parametry odporových, indukčních, kapacitních, optoelektronických a ultrazvukových snímačů. Následně si vybírá integrovaný optoelektronický snímač ADNS-5020, realizuje s ním obvod pro snímání polohy a dále je realizována část pro z...

  3. Model for Analysis of the Energy Demand (MAED) users' manual for version MAED-1

    International Nuclear Information System (INIS)

    1986-09-01

    This manual is organized in two major parts. The first part includes eight main sections describing how to use the MAED-1 computer program and the second one consists of five appendices giving some additional information about the program. Concerning the main sections of the manual, Section 1 gives a summary description and some background information about the MAED-1 model. Section 2 extends the description of the MAED-1 model in more detail. Section 3 introduces some concepts, mainly related to the computer requirements imposed by the program, that are used throughout this document. Sections 4 to 7 describe how to execute each of the various programs (or modules) of the MAED-1 package. The description for each module shows the user how to prepare the control and data cards needed to execute the module and how to interpret the printed output produced. Section 8 recapitulates about the use of MAED-1 for carrying out energy and electricity planning studies, describes the several phases normally involved in this type of study and provides the user with practical hints about the most important aspects that need to be verified at each phase while executing the various MAED modules

  4. Cinéma en France

    Directory of Open Access Journals (Sweden)

    Michel VIGOUROUX

    1992-06-01

    Full Text Available Le cinéma est l’objet de bases de données exhaustives sur les équipements et les fréquentations. Les données sur les salles permettent d’identifier le phénomène de concentration de propriété et d’exploitation. La perspective dynamique peut être observée sur 45 ans. À l’échelle régionale, on peut apprécier le dynamisme du cinéma en haute montagne alpine et la différence de réseaux sur le territoire (France de l’Ouest.

  5. Microcap M&A: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    Keith Turpie

    2014-06-01

    Full Text Available A substantial body of accounting and finance literature has been devoted to the study of Mergers and Acquisitions (M&As dominated by discussions relating to the gains and losses that accrue from transactions involving large public companies. This paper makes a unique contribution to the literature by investigating the M&A experience of microcap businesses. Transactions involving microcap M&A are substantially different to those involving large companies on a number of dimensions. This paper explores the determinants of microcap M&A success and pitfalls and problems from an integration perspective. Due to the paucity of research in the area an exploratory research design is employed, conducting interviews with five CEOs of companies that had each managed multiple transactions. We find microcap M&As are successful when measured against identified goals but generally take longer and cost more than expected. Further, culture and communication are key issues in determining success/failure. We also find the in-house management of integration aspects is problematic for these businesses and suggest this warrants further study.

  6. Ma Ying-jeou’s Presidential Discourse

    Directory of Open Access Journals (Sweden)

    Jonathan Sullivan

    2012-01-01

    Full Text Available Despite the substantial advances made in cross-Strait relations during Ma Ying-jeou’s (Ma Yingjiu first term, the ROC president’s rhetoric varied considerably as he grappled with the difficult reality of implementing campaign and inauguration pledges to establish better relations with China while striving to maintain national respect and sovereignty. In this article, we put forward a framework for measuring, analysing and explaining this variation in President Ma’s first-term discourse. Analysing a very large number of Ma’s speeches, addresses, etc., we provide empirical assessments of how the content of Ma’s public pronouncements has developed over time, how his rhetoric varies according to the strategic context and timing of a speech, and how his discourse compares to that of his predecessor, Chen Shui-bian (Chen Shuibian. In addressing these questions, the article contributes a quantitative perspective to existing work on political discourse in Taiwan and to the growing methodological and applied literature on how to systematically analyse Chinese political text.

  7. Identification and characterization of novel NuMA isoforms.

    Science.gov (United States)

    Wu, Jin; Xu, Zhe; He, Dacheng; Lu, Guanting

    2014-11-21

    The large nuclear mitotic apparatus (NuMA) has been investigated for over 30years with functions related to the formation and maintenance of mitotic spindle poles during mitosis. However, the existence and functions of NuMA isoforms generated by alternative splicing remains unclear. In the present work, we show that at least seven NuMA isoforms (categorized into long, middle and short groups) generated by alternative splicing from a common NuMA mRNA precursor were discovered in HeLa cells and these isoforms differ mainly at the carboxyl terminus and the coiled-coil domains. Two "hotspot" exons with molecular mass of 3366-nt and 42-nt tend to be spliced during alternative splicing in long and middle groups. Furthermore, full-length coding sequences of long and middle NuMA obtained by using fusion PCR were constructed into GFP-tagged vector to illustrate their cellular localization. Long NuMA mainly localized in the nucleus with absence from nucleoli during interphase and translocated to the spindle poles in mitosis. Middle NuMA displayed the similar cell cycle-dependent distribution pattern as long NuMA. However, expression of NuMA short isoforms revealed a distinct subcellular localization. Short NuMA were present in the cytosol during the whole cycle, without colocalization with mitotic apparatus. These results have allowed us tentatively to explore a new research direction for NuMA's various functions. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. Microsoft Azure resursu pārraudzības sistēma

    OpenAIRE

    Ņikiforovs, Arvis

    2016-01-01

    Projekts “Microsoft Azure Resursu Pārraudzības Sistēma” ir sistēma, ar kuras palīdzību var pārraudzīt Microsoft Azure resursu stāvokli, bīstamības paziņojumus, kā arī informāciju par resursu stāvokli izvēlētā laika posmā. Sistēmā ir integrēta Microsoft Azure pierakstīšanās iespēja, tāpēc sistēmu var lietot tikai ar Microsoft Azure kontu. Lietotājam ir tiesības skatīt visus bīstamības paziņojumus, kas ir saistīti ar konkrēto abonementu. Sistēma ir veidota tā, lai tā būtu saprotama un ērta liet...

  9. Identification and characterization of novel NuMA isoforms

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Jin, E-mail: petersdu2112@hotmail.com [Key Laboratory for Cell Proliferation and Regulation of the Ministry of Education, Beijing Normal University, Beijing (China); Xu, Zhe [Department of Clinical Laboratory Diagnosis, Beijing Tiantan Hospital, Capital Medical University, Beijing (China); Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing (China); He, Dacheng [Key Laboratory for Cell Proliferation and Regulation of the Ministry of Education, Beijing Normal University, Beijing (China); Lu, Guanting, E-mail: guantlv@126.com [Beijing DnaLead Science and Technology Co., LTD, Beijing (China)

    2014-11-21

    Highlights: • Seven NuMA isoforms generated by alternative splicing were categorized into 3 groups: long, middle and short. • Both exons 15 and 16 in long NuMA were “hotspot” for alternative splicing. • Lower expression of short NuMA was observed in cancer cells compared with nonneoplastic controls. • Distinct localization pattern of short isoforms indicated different function from that of long and middle NuMA. - Abstract: The large nuclear mitotic apparatus (NuMA) has been investigated for over 30 years with functions related to the formation and maintenance of mitotic spindle poles during mitosis. However, the existence and functions of NuMA isoforms generated by alternative splicing remains unclear. In the present work, we show that at least seven NuMA isoforms (categorized into long, middle and short groups) generated by alternative splicing from a common NuMA mRNA precursor were discovered in HeLa cells and these isoforms differ mainly at the carboxyl terminus and the coiled-coil domains. Two “hotspot” exons with molecular mass of 3366-nt and 42-nt tend to be spliced during alternative splicing in long and middle groups. Furthermore, full-length coding sequences of long and middle NuMA obtained by using fusion PCR were constructed into GFP-tagged vector to illustrate their cellular localization. Long NuMA mainly localized in the nucleus with absence from nucleoli during interphase and translocated to the spindle poles in mitosis. Middle NuMA displayed the similar cell cycle-dependent distribution pattern as long NuMA. However, expression of NuMA short isoforms revealed a distinct subcellular localization. Short NuMA were present in the cytosol during the whole cycle, without colocalization with mitotic apparatus. These results have allowed us tentatively to explore a new research direction for NuMA’s various functions.

  10. Gondwanaland from 650-500 Ma assembly through 320 Ma merger in Pangea to 185-100 Ma breakup: supercontinental tectonics via stratigraphy and radiometric dating

    Science.gov (United States)

    Veevers, J. J.

    2004-12-01

    Gondwanaland lasted from the 650-500 Ma (late Neoproterozoic-Cambrian) amalgamation of African and South American terranes to Antarctica-Australia-India through 320 Ma (mid-Carboniferous) merging with Laurussia in Pangea to breakup from 185 to 100 Ma (Jurassic and Early Cretaceous). Gondwanaland straddled the equator at 540 Ma, lay wholly in the Southern Hemisphere by 350 Ma, and then rotated clockwise so that at 250 Ma Australia reached the S pole and Africa the equator. By initial breakup of Pangea at 185 Ma, Gondwanaland had moved northward such that North Africa reached 35°N. The first clear picture of Gondwanaland, in the Cambrian, shows the assembly of continents with later Laurentian, European and Asian terranes along the "northern" margin, and with a trench along the "western" and "southern" margins, reflected by a 10,000-km-long chain of 530-500 Ma granites. The interior was crossed by the Prydz-Leeuwin and Mozambique Orogenic Belts. The shoreline lapped the flanks of uplifts generated during this complex terminal Pan-Gondwanaland (650-500 Ma) deformation, which endowed Gondwanaland with a thick, buoyant crust and lithosphere and a nonmarine siliciclastic facies. During the Ordovician, terranes drifted from Africa as the first of many transfers of material to the "northern" continents. Central Australia was crossed by the sea, and the eastern margin and ocean floor were flooded by grains of quartz (and 600-500 Ma zircon) from Antarctica. Ice centres in North Africa and southern South America/Africa waxed and waned in the latest Ordovician, Early Silurian, latest Devonian, and Early Carboniferous. In the mid-Carboniferous, Laurussia and Gondwanaland merged in the composite called Pangea by definitive right-lateral contact along the Variscan suture, with collisional stress and subsequent uplift felt as far afield as Australia. Ice sheets developed on the tectonic uplands of Gondwanaland south of 30°S. In the Early Permian, the self-induced heat beneath

  11. Change management in bank M&A

    Directory of Open Access Journals (Sweden)

    Kontić Ljiljana

    2014-01-01

    Full Text Available This paper examines the issues of change management in merger and acquisitions (M&As using the mixed method research approach. The research setting consisted of a foreign bank that operates in Serbia. The main aim of this study is to examine willingness for change in bank M&A. The qualitative data about the bank were sourced from publicly available information about the bank. The standardized questionnaire is used to assess bank's willingness for change. Based on managers structure, the representative sample of middle managers has been interviewed in this study. The research findings revealed possible practical implementation of the questionnaire in the Serbian banking sector. The results revealed that changes in bank should be led top down. The findings add to the existing literature on success factors in cross-border mergers and acquisitions. The study limitation are suggested.

  12. Direito e Macunaíma

    OpenAIRE

    Ganzert, Priscilla Durigan

    2013-01-01

    A pesquisa se propõe a investigar o diálogo entre direito e literatura, tendo por base a análise da obra Macunaíma: o herói sem nenhum caráter, de Mário de Andrade. Primeiramente, aprofunda-se o estudo acerca das relações existentes entre os campos jurídico e literário, como forma de, contrapondo-se ao discurso positivista, contribuir para a crítica do direito. A partir da leitura de François Ost, Stanley Fish, James Boyd White e de outros teóricos do chamado "movimento Direito e Literatura",...

  13. Multiple mechanisms regulate NuMA dynamics at spindle poles.

    Science.gov (United States)

    Kisurina-Evgenieva, Olga; Mack, Gary; Du, Quansheng; Macara, Ian; Khodjakov, Alexey; Compton, Duane A

    2004-12-15

    The large coiled-coil protein NuMA plays an essential role in organizing microtubule minus ends at spindle poles in vertebrate cells. Here, we use both in vivo and in vitro methods to examine NuMA dynamics at mitotic spindle poles. Using fluorescence recovery after photobleaching, we show that an exogenously expressed green-fluorescent-protein/NuMA fusion undergoes continuous exchange between soluble and spindle-associated pools in living cells. These dynamics require cellular energy and display an average half-time for fluorescence recovery of approximately 3 minutes. To explore how NuMA dynamics at spindle poles is regulated, we exploited the association of NuMA with microtubule asters formed in mammalian mitotic extracts. Using a monoclonal antibody specific for human NuMA, we followed the fate of human NuMA associated with microtubule asters upon dilution with a hamster mitotic extract. Consistent with in vivo data, this assay shows that NuMA can be displaced from the core of pre-assembled asters into the soluble pool. The half-time of NuMA displacement from asters under these conditions is approximately 5 minutes. Using this assay, we show that protein kinase activity and the NuMA-binding protein LGN regulate the dynamic exchange of NuMA on microtubule asters. Thus, the dynamic properties of NuMA are regulated by multiple mechanisms including protein phosphorylation and binding to the LGN protein, and the rate of exchange between soluble and microtubule-associated pools suggests that NuMA associates with an insoluble matrix at spindle poles.

  14. St. John's Wort

    Science.gov (United States)

    ... St. John’s wort is a plant with yellow flowers that has been used in traditional European medicine ... E-mail: info@nccih.nih.gov PubMed® A service of the National Library of Medicine, PubMed® contains ...

  15. Candide in St. Louis

    Science.gov (United States)

    Yee, Roger

    1974-01-01

    A young, St. Louis, Missouri, architectural firm, seeking a personal style of practice, has succeeded in creating structures that reveal client input, and which are sensitive, articulate, and at ease with complexity. Describes an elementary school, a condominium, a shopping mall, a high school, and a "community mall." Illustrated with photographs…

  16. [Paracelsus in St. Gallen].

    Science.gov (United States)

    Ochsenbein, P

    1993-12-21

    Once, coming from Nürnberg, Paracelsus interrupted his journey and remained from 1531 to 1533 in the eastern part of Switzerland: First as personal physician of the severely ill mayor of St. Gall, Christian Studer, after the death of Studer (30. 12. 1531) he probably stayed in Roggenhalm near Bühler, a small village in the Canton of Appenzell. In most of the rare testimonies from citizens of St. Gall (Bartlome Schowinger, Johannes Rütiner, Vadian) about the man from Hohenheim he is described negatively as a rather unfavorable, unpleasant outsider. Vadian himself, to whom Paracelsus dedicated the third book of his "Opus Paramirum", obviously avoided him. In St. Gall Paracelsus wrote two prognostic scripts that were promptly printed in Zurich: The "Exposition of the Comet" and the "Exposition of the Arch of Peache". Rütiner tells in his diary about a (finally successful) surgical intervention on a hand operated by Paracelsus. Another successful treatment performed on a monk in December 1533, when he lived in Roggenheim, is registered in the expense-book of the abbot of St. Gall.

  17. Changing the S and MA [Safety and Mission Assurance] Paradigm

    Science.gov (United States)

    Malone, Roy W., Jr.

    2010-01-01

    Objectives: 1) Optimize S&MA organization to best facilitate Shuttle transition in 2010, successfully support Ares developmental responsibilities, and minimize the impacts of the gap between last Shuttle flight and start of Ares V Project. 2) Improve leveraging of critical skills and experience between Shuttle and Ares. 3) Split technical and supervisory functions to facilitate technical penetration. 4) Create Chief Safety and Mission Assurance Officer (CSO) stand-alone position for successfully implementation of S&MA Technical Authority. 5) Minimize disruption to customers. 6) Provide early involvement of S&MA leadership team and frequent/open communications with S&MA team members and steak-holders.

  18. Plagas, enfermedades y malas hierbas del maíz

    OpenAIRE

    Malvar Pintos, Rosa Ana; Ordás Pérez, Amando

    2003-01-01

    Existen muchos enemigos que atacan al cultivo de maíz en sus distintas fases de desarrollo. La principal plaga en España es el taladro y, en los primeros estadios de desarrollo, los gusanos. En el caso de las enfermedades, el maíz se considera un cultivo sin grandes problemas patológicos; más importancia tienen las malas hierbas, sobre todo en terrenos donde el maíz no se rota. Las plagas y enfermedades constituyen un factor limitante de la producción de maíz cuando no se utilizan cultivares ...

  19. [Effect of Electroacupunctrue Stimulation at "Fenglong"(ST 40) on Expression of SREBP-1 c in Non-alcoholic Fatty Liver Disease Rats].

    Science.gov (United States)

    Yu, Min; Li, Gang; Tang, Cheng-Lin; Gao, Rui-Qi; Feng, Qi-Ting; Cao, Jing

    2017-08-25

    To observe the effect of electroacupuncture(EA) stimulation at "Fenglong"(ST 40) on expression of sterol regulatory element binding protein-1 c(SREBP-1 c) in non-alcoholic fatty liver disease(NAFLD) rats, so as to reveal its mechanism underlying improving NAFLD. Male SD rats were randomly divided into normal diet group, high-fat diet group, ST 40 manual acupuncture (MA) group, ST 40 EA group and "Zusanli"(ST 36) EA group( n =12 in each group). Apart from the normal diet group, rats in other groups were fed with high-fat diet to replicate NAFLD model. ST 40 MA group was treated with filiform needling for 20 min, EA (4 Hz/20 Hz, 5 mA) was applied to bilateral acupoints of ST 40 and ST 36 respectively for 20 min in the ST 40 EA group and ST 36 EA group, once a day for 4 weeks. The pathological changes of hepatic tissue were observed by HE staining. The contents of serum free fatty acid (FFA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected by colorimetry. The expression of SREBP-1 c mRNA and protein in the hepatic tissue were detected by reverse transcription-polymerase chain reaction(RT-PCR) and Western blot, respectively. HE staining showed that hepatocytes disorganized with diffuse bullous fat vacuolar changes in rats of the high-fat diet group, and small vesicle steatosis appeared in the ST 40 MA group. The liver cells arranged orderly and the steatosis decreased in the ST 40 EA group and ST 36 EA group. The contents of FFA, ALT, AST in serum and the expression levels of SREBP-1 c mRNA and protein in the hepatic tissue were significantly higher in the high-fat diet group than in the normal diet group( P 40 EA group were better than those in the ST 40 MA group( P 40 EA group in comparison with the ST 36 EA group( P 40 and ST 36 have a positive regulating effect on NAFLD rats, which may be related to down-regulating the expression of SREBP-1 c mRNA and protein in hepatic tissue, improving the endoplasmic reticulum stress and

  20. Oliver St John Gogarty.

    Science.gov (United States)

    Clarke, R W

    1997-01-01

    Oliver St John Gogarty--Otolaryngologist to fashionable Edwardian Dublin--was a distinguished poet and a Senator in the fledgling Irish Free State after its establishment in 1922. He numbered amongst his acquaintances the poet William Butler Yeats, the novelist James Joyce and a host of political and literary persona who helped to shape modern Ireland. He was satirised as 'stately plump Buck Mulligan' in Joyce's novel Ulysses.

  1. St. John's Wort.

    Science.gov (United States)

    Field, H L; Monti, D A; Greeson, J M; Kunkel, E J

    2000-01-01

    The objective of this article is to review the current knowledge of the pharmacology, sites of action, and therapeutic effectiveness of St. John's Wort. The method used was a review of the available literature, using keywords to search the medline database. Bibliographies of the papers, thus obtained, were searched for further documents not referenced by medline. We reviewed papers from this collection. This review reveals that most of the available data on efficacy and safety of St. John's Wort involve its use in mild to moderate depression. Much, but not all of the prevailing opinion is positive. Nevertheless, the quality of therapeutic trials vary so greatly that definitive conclusions are not possible. Both the source and mode of St. John's Wort's therapeutic effect are unclear. We need further controlled studies of effectiveness, safety, and mode of action. In addition to its use in depression, there are reports suggesting possible therapeutic effects in other conditions such as certain malignancies and infections, but these are far too preliminary to permit any conclusions.

  2. How to use MAED with other IAEA models in ENPEP

    International Nuclear Information System (INIS)

    Maksijan, B.

    1997-01-01

    This paper provides an outlook of the energy situation in Croatia and describes the experience with the IAEA planning methodologies with focus on the MAED model. Furthermore, it suggests an approach to integrate the results of the MAED module of ENPEP with other modules (e.g. BALANCE) by means of commercial software (EXCEL Microsoft). (author). 2 figs, 3 tabs

  3. 42 CFR 422.2268 - Standards for MA organization marketing.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Standards for MA organization marketing. 422.2268 Section 422.2268 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Medicare Advantage Marketing Requirements § 422.2268 Standards for MA organizatio...

  4. Large area imaging of forensic evidence with MA-XRF

    NARCIS (Netherlands)

    Langstraat, Kirsten; Knijnenberg, Alwin; Edelman, Gerda; Van De Merwe, Linda; van Loon, A.; Dik, J.; van Asten, Arian C.

    2017-01-01

    This study introduces the use of macroscopic X-ray fluorescence (MA-XRF) for the detection, classification and imaging of forensic traces over large object areas such as entire pieces of clothing and wall paneling. MA-XRF was sufficiently sensitive and selective to detect human biological traces

  5. Large area imaging of forensic evidence with MA-XRF

    NARCIS (Netherlands)

    Langstraat, K.; Knijnenberg, A.; Edelman, G.; van de Merwe, L.; van Loon, A.; Dik, J.; van Asten, A.

    2017-01-01

    This study introduces the use of macroscopic X-ray fluorescence (MA-XRF) for the detection, classification and imaging of forensic traces over large object areas such as entire pieces of clothing and wall paneling. MA-XRF was sufficiently sensitive and selective to detect human biological traces

  6. 42 CFR 422.520 - Prompt payment by MA organization.

    Science.gov (United States)

    2010-10-01

    ... organization will pay 95 percent of the “clean claims” within 30 days of receipt if they are submitted by, or... the MA organization and the relevant provider. (2) The MA organization is obligated to pay contracted... SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for...

  7. MaROS: Information Management Service

    Science.gov (United States)

    Allard, Daniel A.; Gladden, Roy E.; Wright, Jesse J.; Hy, Franklin H.; Rabideau, Gregg R.; Wallick, Michael N.

    2011-01-01

    This software is provided by the Mars Relay Operations Service (MaROS) task to a variety of Mars projects for the purpose of coordinating communications sessions between landed spacecraft assets and orbiting spacecraft assets at Mars. The Information Management Service centralizes a set of functions previously distributed across multiple spacecraft operations teams, and as such, greatly improves visibility into the end-to-end strategic coordination process. Most of the process revolves around the scheduling of communications sessions between the spacecraft during periods of time when a landed asset on Mars is geometrically visible by an orbiting spacecraft. These relay sessions are used to transfer data both to and from the landed asset via the orbiting asset on behalf of Earth-based spacecraft operators. This software component is an application process running as a Java virtual machine. The component provides all service interfaces via a Representational State Transfer (REST) protocol over https to external clients. There are two general interaction modes with the service: upload and download of data. For data upload, the service must execute logic specific to the upload data type and trigger any applicable calculations including pass delivery latencies and overflight conflicts. For data download, the software must retrieve and correlate requested information and deliver to the requesting client. The provision of this service enables several key advancements over legacy processes and systems. For one, this service represents the first time that end-to-end relay information is correlated into a single shared repository. The software also provides the first multimission latency calculator; previous latency calculations had been performed on a mission-by-mission basis.

  8. The (mis)Measurement of M&A Performance

    DEFF Research Database (Denmark)

    Meglio, Olimpia; Risberg, Annette

    2011-01-01

    This paper seeks to further the understanding of the variety of meanings M&A scholars attach to the label “M&A performance” by providing an alternative way to interpret the claimed inconsistency of M&A research findings. While many scholars contend that the problem stems from the multiplicity of M......&A performance measures, we believe the problem rests in trying to compare different measures as if they were measuring the same feature of the organization. Through our narrative review of empirical research we analyze factors shaping the M&A – as well as the organizational – performance measurement process....... The conclusion is that it is not possible to talk about M&A performance as if it was a universal construct....

  9. NuMA overexpression in epithelial ovarian cancer.

    Science.gov (United States)

    Brüning-Richardson, Anke; Bond, Jaqueline; Alsiary, Rawiah; Richardson, Julie; Cairns, David A; McCormac, Luci; Hutson, Richard; Burns, Philip A; Wilkinson, Nafisa; Hall, Geoff D; Morrison, Ewan E; Bell, Sandra M

    2012-01-01

    Highly aneuploid tumours are common in epithelial ovarian cancers (EOC). We investigated whether NuMA expression was associated with this phenomenon.NuMA protein levels in normal and tumour tissues, ovarian cell lines and primary cultures of malignant cells derived from ovarian ascitic fluids were analysed by Affymetrix microarray analysis, immunoblotting, immunohistochemistry (IHC) and immunofluorescence (IF), with results correlated to associated clinical data. Aneuploidy status in primary cultures was determined by FACS analysis.Affymetrix microarray data indicated that NuMA was overexpressed in tumour tissue, primary cultures and cell lines compared to normal ovarian tissue. IHC revealed low to weak NuMA expression in normal tissues. Expression was upregulated in tumours, with a significant association with disease stage in mucinous EOC subtypes (p = 0.009), lymph node involvement (p = 0.03) and patient age (p = 0.04). Additional discontinuous data analysis revealed that high NuMA levels in tumours decreased with grade (p = 0.02) but increased with disease stage (p = 0.04) in serous EOC. NuMA expression decreased in late disease stage 4 endometrioid EOCs. High NuMA levels decreased with increased tumour invasion in all subtypes (p = 0.03). IF of primary cultures revealed that high NuMA levels at mitotic spindle poles were significantly associated with a decreased proportion of cells in cytokinesis (p = 0.05), increased binucleation (p = 0.021) and multinucleation (p = 0.007), and aneuploidy (p = 0.008).NuMA is highly expressed in EOC tumours and high NuMA levels correlate with increases in mitotic defects and aneuploidy in primary cultures.

  10. NuMA overexpression in epithelial ovarian cancer.

    Directory of Open Access Journals (Sweden)

    Anke Brüning-Richardson

    Full Text Available Highly aneuploid tumours are common in epithelial ovarian cancers (EOC. We investigated whether NuMA expression was associated with this phenomenon.NuMA protein levels in normal and tumour tissues, ovarian cell lines and primary cultures of malignant cells derived from ovarian ascitic fluids were analysed by Affymetrix microarray analysis, immunoblotting, immunohistochemistry (IHC and immunofluorescence (IF, with results correlated to associated clinical data. Aneuploidy status in primary cultures was determined by FACS analysis.Affymetrix microarray data indicated that NuMA was overexpressed in tumour tissue, primary cultures and cell lines compared to normal ovarian tissue. IHC revealed low to weak NuMA expression in normal tissues. Expression was upregulated in tumours, with a significant association with disease stage in mucinous EOC subtypes (p = 0.009, lymph node involvement (p = 0.03 and patient age (p = 0.04. Additional discontinuous data analysis revealed that high NuMA levels in tumours decreased with grade (p = 0.02 but increased with disease stage (p = 0.04 in serous EOC. NuMA expression decreased in late disease stage 4 endometrioid EOCs. High NuMA levels decreased with increased tumour invasion in all subtypes (p = 0.03. IF of primary cultures revealed that high NuMA levels at mitotic spindle poles were significantly associated with a decreased proportion of cells in cytokinesis (p = 0.05, increased binucleation (p = 0.021 and multinucleation (p = 0.007, and aneuploidy (p = 0.008.NuMA is highly expressed in EOC tumours and high NuMA levels correlate with increases in mitotic defects and aneuploidy in primary cultures.

  11. Morotochoerus from Uganda (17.5 Ma and Kenyapotamus from Kenya (13-11 Ma: implications for hippopotamid origins

    Directory of Open Access Journals (Sweden)

    Pickford, M.

    2011-12-01

    Full Text Available The aim of this paper is to describe and interpret suiform teeth from Moroto, Uganda, and Ngorora, Kenya, which contribute to the debate about hippo-anthracothere-whale relationships. The early stages of hippopotamid evolution are relatively poorly known on account of the paucity of their fossil record older than 7 Ma. New specimens of Morotochoerus from Uganda reveal that it is not closely related to Hippopotamidae; the superficial resemblances of the cheek teeth to those of hippos represent convergences and not homologies. Restricted samples of Palaeopotamus ternani are available from the Middle Miocene of Kenya {Maboko, ca 16 Ma; Muruyur, ca 14.5 Ma; Fort Ternan, ca 13.7 Ma} while from the base of the late Miocene, Kenyapotamus coryndonae is known from Kenya {Ngerngerwa, ca 10.5-10 Ma; Nakali, ca 10.5 Ma; Samburu Hills, ca 9.5 Ma}, Ethiopia {Ch’orora, ca 10.5 Ma} and Tunisia {Beglia Formation ca 11-10 Ma}. The recovery of specimens of Kenyapotamus from the Ngorora Formation, Kenya, aged ca 11 Ma, is of interest because it includes well preserved teeth, including an m/3 in good condition. These specimens support the hypothesis that hippopotamids descended from palaeochoerids and not from anthracotheres.El objetivo de este trabajo es describir e interpretar los dientes suiformes de Moroto, Uganda, y Ngorora, Kenia, que contribuyen al debate sobre las relaciones hipo-anthracothere-whale. Las primeras etapas de la evolución de los hipopotámidos son relativamente poco conocidas a causa de la escasez de su registro fósil en edades superiors a los 7 Ma. Nuevos ejemplares de Morotochoerus en Uganda revelan que no están estrechamente relacionados con Hippopotamidae, las semejanzas superficiales de los dientes de la mandíbula con los de los hipopótamos representan convergencias y no homologías. Algunas muestras de Palaeopotamus ternani aparecen en el Medio Mioceno de Kenia {Maboko, ca 16 Ma; Muruyur, ca 14.5 Ma; Fort Ternan, ca 13.7 Ma

  12. Mount St. Helens Rebirth

    Science.gov (United States)

    2002-01-01

    The catastrophic eruption of Mt. St. Helens 20 years ago today (on May 18, 1980), ranks among the most important natural events of the twentieth century in the United States. Because Mt. St. Helens is in a remote area of the Cascades Mountains, only a few people were killed by the eruption, but property damage and destruction totaled in the billions of dollars. Mount St. Helens is an example of a composite or stratovolcano. These are explosive volcanoes that are generally steep-sided, symmetrical cones built up by the accumulation of debris from previous eruptions and consist of alternating layers of lava flows, volcanic ash and cinder. Some of the most photographed mountains in the world are stratovolcanoes, including Mount Fuji in Japan, Mount Cotopaxi in Ecuador, Mount Hood in Oregon, and Mount Rainier in Washington. The recently erupting Mount Usu on the island of Hokkaido in Japan is also a stratovolcano. Stratovolcanoes are characterized by having plumbing systems that move magma from a chamber deep within the Earth's crust to vents at the surface. The height of Mt. St. Helens was reduced from about 2950 m (9677 ft) to about 2550 m (8364 ft) as a result of the explosive eruption on the morning of May 18. The eruption sent a column of dust and ash upwards more than 25 km into the atmosphere, and shock waves from the blast knocked down almost every tree within 10 km of the central crater. Massive avalanches and mudflows, generated by the near-instantaneous melting of deep snowpacks on the flanks of the mountain, devastated an area more than 20 km to the north and east of the former summit, and rivers choked with all sorts of debris were flooded more than 100 km away. The area of almost total destruction was about 600 sq. km. Ash from the eruption cloud was rapidly blown to the northeast and east producing lightning which started many small forest fires. An erie darkness caused by the cloud enveloped the landscape more than 200 km from the blast area, and ash

  13. Ma ma (2015. A reflection of the Spanish woman with breast cáncer

    Directory of Open Access Journals (Sweden)

    Clara PERALTA NUENO

    2017-12-01

    Full Text Available Ma ma (2015 is a Spanish drama film directed by Julio Medem and produced by Morena Films. This film tells the story of Magda’s life, whose character is interpreted by Penélope Cruz. After being diagnosed with a breast cancer, Magda, an unemployed teacher, will not know how to act nor how this disease will change her life. But little by little, she will bring into the surface all her vital energy. Breast cancer represents the most frequent type of cancer among women. Although the majority of the identified risk factors can be modified, the health systems focus on activities that let strengthen the primary prevention and activities of secondary and tertiary prevention. The early detection and the right treatment are essential to fight against this disease. The emotional process caused by the presence of cancer involves a mechanism of psychic reconstitution that allows the patient develop an answer to the organic, cognitive, social, and emotional challenges they have to deal with. This process is easier when they have a solid socio-family support network among other factors.

  14. Model for Analysis of Energy Demand (MAED-2). User's manual

    International Nuclear Information System (INIS)

    2006-01-01

    The IAEA has been supporting its Member States in the area of energy planning for sustainable development. Development and dissemination of appropriate methodologies and their computer codes are important parts of this support. This manual has been produced to facilitate the use of the MAED model: Model for Analysis of Energy Demand. The methodology of the MAED model was originally developed by. B. Chateau and B. Lapillonne of the Institute Economique et Juridique de l'Energie (IEJE) of the University of Grenoble, France, and was presented as the MEDEE model. Since then the MEDEE model has been developed and adopted to be appropriate for modelling of various energy demand system. The IAEA adopted MEDEE-2 model and incorporated important modifications to make it more suitable for application in the developing countries, and it was named as the MAED model. The first version of the MAED model was designed for the DOS based system, which was later on converted for the Windows system. This manual presents the latest version of the MAED model. The most prominent feature of this version is its flexibility for representing structure of energy consumption. The model now allows country-specific representations of energy consumption patterns using the MAED methodology. The user can now disaggregate energy consumption according to the needs and/or data availability in her/his country. As such, MAED has now become a powerful tool for modelling widely diverse energy consumption patterns. This manual presents the model in details and provides guidelines for its application

  15. Model for Analysis of Energy Demand (MAED-2)

    International Nuclear Information System (INIS)

    2007-01-01

    The IAEA has been supporting its Member States in the area of energy planning for sustainable development. Development and dissemination of appropriate methodologies and their computer codes are important parts of this support. This manual has been produced to facilitate the use of the MAED model: Model for Analysis of Energy Demand. The methodology of the MAED model was originally developed by. B. Chateau and B. Lapillonne of the Institute Economique et Juridique de l'Energie (IEJE) of the University of Grenoble, France, and was presented as the MEDEE model. Since then the MEDEE model has been developed and adopted to be appropriate for modelling of various energy demand system. The IAEA adopted MEDEE-2 model and incorporated important modifications to make it more suitable for application in the developing countries, and it was named as the MAED model. The first version of the MAED model was designed for the DOS based system, which was later on converted for the Windows system. This manual presents the latest version of the MAED model. The most prominent feature of this version is its flexibility for representing structure of energy consumption. The model now allows country-specific representations of energy consumption patterns using the MAED methodology. The user can now disaggregate energy consumption according to the needs and/or data availability in her/his country. As such, MAED has now become a powerful tool for modelling widely diverse energy consumption patterns. This manual presents the model in details and provides guidelines for its application

  16. Model for Analysis of Energy Demand (MAED-2). User's manual

    International Nuclear Information System (INIS)

    2007-01-01

    The IAEA has been supporting its Member States in the area of energy planning for sustainable development. Development and dissemination of appropriate methodologies and their computer codes are important parts of this support. This manual has been produced to facilitate the use of the MAED model: Model for Analysis of Energy Demand. The methodology of the MAED model was originally developed by. B. Chateau and B. Lapillonne of the Institute Economique et Juridique de l'Energie (IEJE) of the University of Grenoble, France, and was presented as the MEDEE model. Since then the MEDEE model has been developed and adopted to be appropriate for modelling of various energy demand system. The IAEA adopted MEDEE-2 model and incorporated important modifications to make it more suitable for application in the developing countries, and it was named as the MAED model. The first version of the MAED model was designed for the DOS based system, which was later on converted for the Windows system. This manual presents the latest version of the MAED model. The most prominent feature of this version is its flexibility for representing structure of energy consumption. The model now allows country-specific representations of energy consumption patterns using the MAED methodology. The user can now disaggregate energy consumption according to the needs and/or data availability in her/his country. As such, MAED has now become a powerful tool for modelling widely diverse energy consumption patterns. This manual presents the model in details and provides guidelines for its application

  17. Design of Earth Leakage Circuit Breaker on Sensitivity 20 MA

    Directory of Open Access Journals (Sweden)

    Pandung Sarungallo

    2008-08-01

    Full Text Available Electrics current can flow out to the ground by using a human body. This electric current will be dangerous to the human when it exceed 20mA. A very sensitive earth leakage circuit breaker (ELCB is needed to anticipate the leaky current but most of ELCB can only be found in the market with sensitivitas 30mA or bigger. This research is succees to design an ELCB with sensitivity 20mA. Characteristic of an ELCB is very influenced by the current transformer characteristic and the relay which are used.

  18. Communication from ST Group

    CERN Document Server

    TS Department

    2008-01-01

    In order to prepare the organization of the Open Days, please note that FM Group will not able to take into account either specific requests for waste collection from 2nd to 6th of April, either removal or PC transport requests between the 31st and the 11th of March. We kindly ask you to plan the collection of any type of waste and the urgent transport of office furniture or PC before the 31st of March. Waste collection requests shall be formulated contacting FM Support at 77777 or at the email address mailto:Fm.Support@cern.ch; removal of office furniture or PC transport requests must be made using the EDH ‘Transport request’ form selecting the "Removals" or the "PC transport" category from the drop-down menu. For any question concerning the waste sorting, please consult the following web address: http://dechets-waste.web.cern.ch/dechets-waste/. Thank you for your understanding and collaboration. TS/FM Group

  19. Mount St. Helens Flyover

    Science.gov (United States)

    2002-01-01

    This Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) image of Mt. St. Helens volcano in Washington State was acquired on August 8, 2000 and covers an area of 37 by 51 km. Mount Saint Helens, a volcano in the Cascade Range of southwestern Washington that had been dormant since 1857, began to show signs of renewed activity in early 1980. On 18 May 1980, it erupted with such violence that the top of the mountain was blown off, spewing a cloud of ash and gases that rose to an altitude of 19 kilometers. The blast killed about 60 people and destroyed all life in an area of some 180 square kilometers (some 70 square miles), while a much larger area was covered with ash and debris. It continues to spit forth ash and steam intermittently. As a result of the eruption, the mountain's elevation decreased from 2,950 meters to 2,549 meters. The simulated fly-over was produced by draping ASTER visible and near infrared image data over a digital topography model, created from ASTER's 3-D stereo bands. The color was computer enhanced to create a 'natural' color image, where the vegetation appears green. The topography has been exaggerated 2 times to enhance the appearance of the relief. Landsat7 aquired an image of Mt. St. Helens on August 22, 1999. Image and animation courtesy NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

  20. The banana fruit Dof transcription factor MaDof23 acts as a repressor and interacts with MaERF9 in regulating ripening-related genes.

    Science.gov (United States)

    Feng, Bi-hong; Han, Yan-chao; Xiao, Yun-yi; Kuang, Jian-fei; Fan, Zhong-qi; Chen, Jian-ye; Lu, Wang-jin

    2016-04-01

    The DNA binding with one finger (Dof) proteins, a family of plant-specific transcription factors, are involved in a variety of plant biological processes. However, little information is available on their involvement in fruit ripening. We have characterized 25 MaDof genes from banana fruit (Musa acuminata), designated as MaDof1-MaDof25 Gene expression analysis in fruit subjected to different ripening conditions revealed that MaDofs were differentially expressed during different stages of ripening. MaDof10, 23, 24, and 25 were ethylene-inducible and nuclear-localized, and their transcript levels increased during fruit ripening. Moreover, yeast two-hybrid and bimolecular fluorescence complementation analyses demonstrated a physical interaction between MaDof23 and MaERF9, a potential regulator of fruit ripening reported in a previous study. We determined that MaDof23 is a transcriptional repressor, whereas MaERF9 is a transcriptional activator. We suggest that they might act antagonistically in regulating 10 ripening-related genes, including MaEXP1/2/3/5, MaXET7, MaPG1, MaPME3, MaPL2, MaCAT, and MaPDC, which are associated with cell wall degradation and aroma formation. Taken together, our findings provide new insight into the transcriptional regulation network controlling banana fruit ripening. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  1. Contact Aligner 2 (Front Side): Suss Microtec MA8

    Data.gov (United States)

    Federal Laboratory Consortium — Description:CORAL Name: SussMA8This system utilizes 1X contact lithography to transfer photomask patterns onto substrates Specifications / Capabilities:UV broadband...

  2. NuMA after 30 years: the matrix revisited.

    Science.gov (United States)

    Radulescu, Andreea E; Cleveland, Don W

    2010-04-01

    The large nuclear mitotic apparatus (NuMA) protein is an abundant component of interphase nuclei and an essential player in mitotic spindle assembly and maintenance. With its partner, cytoplasmic dynein, NuMA uses its cross-linking properties to tether microtubules to spindle poles. NuMA and its invertebrate homologs play a similar tethering role at the cell cortex, thereby mediating essential asymmetric divisions during development. Despite its maintenance as a nuclear component for decades after the final mitosis of many cell types (including neurons), an interphase role for NuMA remains to be established, although its structural properties implicate it as a component of a nuclear scaffold, perhaps as a central constituent of the proposed nuclear matrix. Copyright 2010. Published by Elsevier Ltd.

  3. Millennium Ecosystem Assessment: MA Rapid Land Cover Change

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Rapid Land Cover Change provides data and information on global and regional land cover change in raster format for...

  4. Millennium Ecosystem Assessment: MA Climate and Land Cover

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Climate and Land Cover provides data and information on global gridded climatological variables, global land cover maps, and...

  5. 42 CFR 422.74 - Disenrollment by the MA organization.

    Science.gov (United States)

    2010-10-01

    ... to the use of medical services or compliance (or noncompliance) with medical advice or treatment. (ii... medical expertise review the case before making the final decision. The MA organization will be required...

  6. Electrocardiogram score for the selection of reperfusion strategy in early latecomers with ST-segment elevation myocardial infarction.

    Science.gov (United States)

    Zhang, Yu-Jiao; Zheng, Wen; Sun, Jian; Li, Guo-Li; Chi, Bao-Rong

    2015-01-01

    The clinical benefit of percutaneous coronary intervention (PCI) is controversial in ST-segment elevation myocardial infarction (STEMI) patients presenting 12-72 hours after symptom onset. Several studies suggested this conflicting result was associated with myocardial area at risk (MaR) of enrolled patients. MaR could be estimated by the electrocardiogram (ECG) score. Our objective was to evaluate the benefits of PCI in STEMI latecomers with different MaR. We constructed a prospective cohort involving 436 patients presenting 12-72 hours after STEMI onset and who met an inclusion criteria. 218 underwent PCI and 218 received the optimal medical therapy (OMT) alone. Individual MaR was quantified by the combined Aldrich ST and Selvester QRS score. The primary endpoint was a composite of cardiovascular death, reinfarction or revascularization within two years. The 2-year cumulative primary endpoint rate was respectively 9.2% in PCI group and 5.3% in OMT group when MaR<35% (adjusted hazard ratio for PCI vs. OMT, 1.855; 95% confidence interval [CI], 0.617-5.575; P=0.271), and was 12.8% in PCI group and 23.1% in OMT group when MaR ≥35% (adjusted hazard ratio for PCI vs. OMT, 0.448; 95% CI, 0.228-0.884; P=0.021). The benefit of PCI for the STEMI latecomers was associated with the MaR. PCI, compared with OMT, could significantly reduce the 2-year primary outcomes in patients with MaR≥35%, but not in ones with MaR<35%. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. NuMA Overexpression in Epithelial Ovarian Cancer

    OpenAIRE

    Brüning-Richardson, Anke; Bond, Jaqueline; Alsiary, Rawiah; Richardson, Julie; Cairns, David A.; McCormac, Luci; Hutson, Richard; Burns, Philip A.; Wilkinson, Nafisa; Hall, Geoff D.; Morrison, Ewan E.; Bell, Sandra M.

    2012-01-01

    Highly aneuploid tumours are common in epithelial ovarian cancers (EOC). We investigated whether NuMA expression was associated with this phenomenon. NuMA protein levels in normal and tumour tissues, ovarian cell lines and primary cultures of malignant cells derived from ovarian ascitic fluids were analysed by Affymetrix microarray analysis, immunoblotting, immunohistochemistry (IHC) and immunofluorescence (IF), with results correlated to associated clinical data. Aneuploidy status in primary...

  8. MaNGA: Mapping Nearby Galaxies at Apache Point Observatory

    Science.gov (United States)

    Weijmans, A.-M.; MaNGA Team

    2016-10-01

    MaNGA (Mapping Nearby Galaxies at APO) is a galaxy integral-field spectroscopic survey within the fourth generation Sloan Digital Sky Survey (SDSS-IV). It will be mapping the composition and kinematics of gas and stars in 10,000 nearby galaxies, using 17 differently sized fiber bundles. MaNGA's goal is to provide new insights in galaxy formation and evolution, and to deliver a local benchmark for current and future high-redshift studies.

  9. Correlations between silicic volcanic rocks of the St Mary's Islands (southwestern India) and eastern Madagascar

    DEFF Research Database (Denmark)

    Melluso, Leone; Sheth, Hetu C.; Mahoney, John J.

    2009-01-01

    The St Mary's, Islands (southwestern India) expose silicic volcanic and sub-volcanic rocks (rhyolites and granophyric dacites) emplaced contemporaneously with the Cretaceous igneous province of Madagascar, roughly 88-90 Ma ago. I he St Mary's Islands rocks have phenocrysts of plagioclase, clinopy......The St Mary's, Islands (southwestern India) expose silicic volcanic and sub-volcanic rocks (rhyolites and granophyric dacites) emplaced contemporaneously with the Cretaceous igneous province of Madagascar, roughly 88-90 Ma ago. I he St Mary's Islands rocks have phenocrysts of plagioclase...... and isotopic Compositions very close to those of rhyolites exposed between Vatomandry Ilaka and Mananjary in eastern Madagascar, and are distinctly different from rhyolites front other sectors of the Madagascan province. We therefore postulate that the St Mary's and the Vatomandry-Ilaka Mananjary silicic rock...... outcrops were adjacent before the Late Cretaceous rifting that split Madagascar from India, If so, they provide a valuable tool to check and aid traditional Cretaceous India Madagascar reconstructions based on palaeomagnetism, matching Precambrian geological features, and geometric fitting of continental...

  10. StUbEx

    DEFF Research Database (Denmark)

    Akimov, Vyacheslav; Henningsen, Jeanette; Hallenborg, Philip

    2014-01-01

    Post-translational modification of proteins with the small polypeptide ubiquitin plays a pivotal role in many cellular processes, altering protein lifespan, location, and function and regulating protein-protein interactions. Ubiquitination exerts its diverse functions through complex mechanisms...... by formation of different polymeric chains and subsequent recognition of the ubiquitin signal by specific protein interaction domains. Despite some recent advances in the analytical tools for the analysis of ubiquitination by mass spectrometry, there is still a need for additional strategies suitable...... for investigation of cellular ubiquitination at the proteome level. Here, we present a stable tagged ubiquitin exchange (StUbEx) cellular system in which endogenous ubiquitin is replaced with an epitope-tagged version, thereby allowing specific and efficient affinity purification of ubiquitinated proteins...

  11. Mt. St. Helens

    Science.gov (United States)

    2001-01-01

    [figure removed for brevity, see original site] [figure removed for brevity, see original site] Figure 1 Movie This 3-D anaglyph image of Mt. St. Helens volcano combines the nadir-looking and back-looking band 3 images of ASTER. To view the image in stereo, you will need blue-red glasses. Make sure to look through the red lens with your left eye. Figure 1: This ASTER image of Mt. St. Helens volcano in Washington was acquired on August 8, 2000 and covers an area of 37 by 51 km. Mount Saint Helens, a volcano in the Cascade Range of southwestern Washington that had been dormant since 1857, began to show signs of renewed activity in early 1980. On 18 May 1980, it erupted with such violence that the top of the mountain was blown off, spewing a cloud of ash and gases that rose to an altitude of 19 kilometers. The blast killed about 60 people and destroyed all life in an area of some 180 square kilometers (some 70 square miles), while a much larger area was covered with ash and debris. It continues to spit forth ash and steam intermittently. As a result of the eruption, the mountain's elevation decreased from 2,950 meters to 2,549 meters. The image is centered at 46.2 degrees north latitude, 122.2 degrees west longitude. Movie: The simulated fly-over was produced by draping ASTER visible and near infrared image data over a digital topography model, created from ASTER's 3-D stereo bands. The color was computer enhanced to create a natural color image, where the vegetation appears green. The topography has been exaggerated 2 times to enhance the appearance of the relief. The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  12. Comparative Genomic Characterization of the Highly Persistent and Potentially Virulent Cronobacter sakazakii ST83, CC65 Strain H322 and Other ST83 Strains

    Directory of Open Access Journals (Sweden)

    Hannah R. Chase

    2017-06-01

    Full Text Available Cronobacter (C. sakazakii is an opportunistic pathogen and has been associated with serious infections with high mortality rates predominantly in pre-term, low-birth weight and/or immune compromised neonates and infants. Infections have been epidemiologically linked to consumption of intrinsically and extrinsically contaminated lots of reconstituted powdered infant formula (PIF, thus contamination of such products is a challenging task for the PIF producing industry. We present the draft genome of C. sakazakii H322, a highly persistent sequence type (ST 83, clonal complex (CC 65, serotype O:7 strain obtained from a batch of non-released contaminated PIF product. The presence of this strain in the production environment was traced back more than 4 years. Whole genome sequencing (WGS of this strain together with four more ST83 strains (PIF production environment-associated confirmed a high degree of sequence homology among four of the five strains. Phylogenetic analysis using microarray (MA and WGS data showed that the ST83 strains were highly phylogenetically related and MA showed that between 5 and 38 genes differed from one another in these strains. All strains possessed the pESA3-like virulence plasmid and one strain possessed a pESA2-like plasmid. In addition, a pCS1-like plasmid was also found. In order to assess the potential in vivo pathogenicity of the ST83 strains, each strain was subjected to infection studies using the recently developed zebrafish embryo model. Our results showed a high (90–100% zebrafish mortality rate for all of these strains, suggesting a high risk for infections and illness in neonates potentially exposed to PIF contaminated with ST83 C. sakazakii strains. In summary, virulent ST83, CC65, serotype CsakO:7 strains, though rarely found intrinsically in PIF, can persist within a PIF manufacturing facility for years and potentially pose significant quality assurance challenges to the PIF manufacturing industry.

  13. Atklātā pirmkoda resursu vadības sistēma OpenERP

    OpenAIRE

    Grigore, Madara

    2016-01-01

    Maģistra darbā “Atklātā pirmkoda resursu vadības sistēma OpenERP” tiek pētīts, kas ir resursu vadības sistēma (ERP), tiek aplūkotas, kādas ir atšķirības starp patentēto un atklātā pirmkoda ERP sistēmām un izpētīts, ko uzņēmums iegūst, ieviešot ERP risinājumu, un kādi ir iespējamie riski ar kuriem var saskarties uzņēmums pēc ERP risinājuma implementācijas. Tiek pētīts, kāpēc un kādas nesaderības var rasties starp uzņēmumu un ERP programmu, kā tās var mazināt. Darbā tiek pētīta atklātā pirmkoda...

  14. Divisions-ST Formation

    CERN Document Server

    Henny, L

    2001-01-01

    Au CERN la formation est une partie intégrante des activités de l'Organisation. Mentionnée dans le Statut du Personnel depuis l'origine, elle figure au Règlement depuis 1981 et est largement explicitée dans la Circulaire Administrative N° 16. L'organe réglementaire est constitué par la Commission Paritaire de Formation (Joint Training Board dont le sigle est JTB) qui a pour but de conseiller le Directeur Général en matière de formation, de définir la politique de formation et d'en faire l'évaluation. Des organes spécifiques ont été mis en place pour organiser les différents programmes : le Groupe Formation et Développement, le Comité exécutif de formation (sigle TEC), le Comité d'enseignement académique. Des délégués divisionnaires à la formation (sigle DTO) servent de courroie de transmission entre ces organes, le personnel et le Service de l'Enseignement (Div. HR). La Division ST dont les activités présentent une grande variété se doit de poursuivre une politique de formation s...

  15. Diet of Theropithecus from 4 to 1 Ma in Kenya.

    Science.gov (United States)

    Cerling, Thure E; Chritz, Kendra L; Jablonski, Nina G; Leakey, Meave G; Manthi, Fredrick Kyalo

    2013-06-25

    Theropithecus was a common large-bodied primate that co-occurred with hominins in many Plio-Pleistocene deposits in East and South Africa. Stable isotope analyses of tooth enamel from T. brumpti (4.0-2.5 Ma) and T. oswaldi (2.0-1.0 Ma) in Kenya show that the earliest Theropithecus at 4 Ma had a diet dominated by C4 resources. Progressively, this genus increased the proportion of C4-derived resources in its diet and by 1.0 Ma, had a diet that was nearly 100% C4-derived. It is likely that this diet was comprised of grasses or sedges; stable isotopes cannot, by themselves, give an indication of the relative importance of leaves, seeds, or underground storage organs to the diet of this primate. Theropithecus throughout the 4- to 1-Ma time range has a diet that is more C4-based than contemporaneous hominins of the genera Australopithecus, Kenyanthropus, and Homo; however, Theropithecus and Paranthropus have similar proportions of C4-based resources in their respective diets.

  16. The 2730 Ma onset of the Neoarchean Yilgarn Orogeny

    Science.gov (United States)

    Zibra, I.; Clos, F.; Weinberg, R. F.; Peternell, M.

    2017-09-01

    The timing of the onset of an orogeny is commonly constrained indirectly, because early orogenic structures are rarely exposed or are overprinted. Establishing the onset of an Archean orogeny is considerably more challenging, because of the more fragmented geological record and the general lack of consensus about Archean geodynamics. We combine existing tectonostratigraphic data with new structural and geophysical data sets to establish the onset of the Neoarchean Yilgarn Orogeny (Yilgarn Craton, Western Australia). We show that the surface of the 2960-2750 Ma deep-marine Yilgarn greenstone sequence was uplifted, eroded, and unconformably overlain by an 2730 Ma, syntectonic clastic sequence, deposited in shallow marine to subaerial conditions, and derived from the erosion of the underlying greenstones. This 2730 Ma regional unconformity predates the oldest known Yilgarn structures; therefore, its tectonic significance is so far unknown. At around the same time, at deeper crustal levels, the 2728 Ma Yarraquin pluton was being emplaced along an active, large-scale shear zone network. Our mesostructural and microstructural analysis shows that the bulk of the fabric in the granite and its country rocks developed during pluton emplacement and was largely assisted by magma-present shearing. Overall, these structures reflect an important event of synemplacement crustal shortening. The regional unconformity and the syndeformational emplacement of the Yarraquin pluton are both expressions of an 2730 Ma regional deformation event associated with significant crustal thickening, marking the onset of the Neoarchean Yilgarn Orogeny.

  17. Large area imaging of forensic evidence with MA-XRF.

    Science.gov (United States)

    Langstraat, Kirsten; Knijnenberg, Alwin; Edelman, Gerda; van de Merwe, Linda; van Loon, Annelies; Dik, Joris; van Asten, Arian

    2017-11-08

    This study introduces the use of macroscopic X-ray fluorescence (MA-XRF) for the detection, classification and imaging of forensic traces over large object areas such as entire pieces of clothing and wall paneling. MA-XRF was sufficiently sensitive and selective to detect human biological traces like blood, semen, saliva, sweat and urine on fabric on the basis of Fe, Zn, K, Cl and Ca elemental signatures. With MA-XRF a new chemical contrast is introduced for human stain detection and this can provide a valuable alternative when the evidence item is challenging for conventional techniques. MA-XRF was also successfully employed for the chemical imaging and classification of gunshot residues (GSR). The full and non-invasive elemental mapping (Pb, Ba, Sr, K and Cl) of intact pieces of clothing allows for a detailed shooting incident reconstruction linking firearms and ammunition to point of impact and providing information on the shooting angle. In high resolution mode MA-XRF can even be used to provide information on the shooting order of different ammunition types. Finally, by using the surface penetration of X-rays we demonstrate that the lead signature of a bullet impact can be easily detected even if covered by multiple layers of wall paint or human blood.

  18. Changing the Safety and Mission Assurance (S and MA) Paradigm

    Science.gov (United States)

    Malone, Roy W.; Safie, Fayssal M.

    2010-01-01

    This slide presentation reviews the change in the work and impact of the Safety and Mission Assurance directorate at Marshall Space Flight Center. It reviews the background and the reasons given for a strong Safety & Mission Assurance presence in all planning for space flight. This was pointed out by the Rogers Commission Report after the Space Challenger accident, by the Columbia Accident Investigation Board (CAIB) and by a 2006 NASA Exploration Safety Study (NESS) Team. The overall objective of the work in this area was to improve and maintain S&MA expertise and skills. Training for this work was improved and the S&MA organization was reorganized. This has resulted in a paradigm shift for NASA's safety efforts, which is described. The presentation then reviews the impact of the new S&MA work in the Ares I design and development.

  19. Comprehensive analysis of NuMA variation in breast cancer

    International Nuclear Information System (INIS)

    Kilpivaara, Outi; Rantanen, Matias; Tamminen, Anitta; Aittomäki, Kristiina; Blomqvist, Carl; Nevanlinna, Heli

    2008-01-01

    A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. In order to evaluate the NuMa gene for breast cancer susceptibility, we have here screened the entire coding region and exon-intron boundaries of NuMa in 92 familial breast cancer patients and constructed haplotypes of the identified variants. Five missense variants were further screened in 341 breast cancer cases with a positive family history and 368 controls. We examined the frequency of Ala794Gly in an extensive series of familial (n = 910) and unselected (n = 884) breast cancer cases and controls (n = 906), with a high power to detect the suggested breast cancer risk. We also tested if the variant is associated with histopathologic features of breast tumors. Screening of NuMA resulted in identification of 11 exonic variants and 12 variants in introns or untranslated regions. Five missense variants that were further screened in breast cancer cases with a positive family history and controls, were each carried on a unique haplotype. None of the variants, or the haplotypes represented by them, was associated with breast cancer risk although due to low power in this analysis, very low risk alleles may go unrecognized. The NuMA Ala794Gly showed no difference in frequency in the unselected breast cancer case series or familial case series compared to control cases. Furthermore, Ala794Gly did not show any significant association with histopathologic characteristics of the tumors, though Ala794Gly was slightly more frequent among unselected cases with lymph node involvement. Our results do not support the role of NuMA variants as breast cancer susceptibility alleles

  20. Comprehensive analysis of NuMA variation in breast cancer.

    Science.gov (United States)

    Kilpivaara, Outi; Rantanen, Matias; Tamminen, Anitta; Aittomäki, Kristiina; Blomqvist, Carl; Nevanlinna, Heli

    2008-03-10

    A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. In order to evaluate the NuMa gene for breast cancer susceptibility, we have here screened the entire coding region and exon-intron boundaries of NuMa in 92 familial breast cancer patients and constructed haplotypes of the identified variants. Five missense variants were further screened in 341 breast cancer cases with a positive family history and 368 controls. We examined the frequency of Ala794Gly in an extensive series of familial (n = 910) and unselected (n = 884) breast cancer cases and controls (n = 906), with a high power to detect the suggested breast cancer risk. We also tested if the variant is associated with histopathologic features of breast tumors. Screening of NuMA resulted in identification of 11 exonic variants and 12 variants in introns or untranslated regions. Five missense variants that were further screened in breast cancer cases with a positive family history and controls, were each carried on a unique haplotype. None of the variants, or the haplotypes represented by them, was associated with breast cancer risk although due to low power in this analysis, very low risk alleles may go unrecognized. The NuMA Ala794Gly showed no difference in frequency in the unselected breast cancer case series or familial case series compared to control cases. Furthermore, Ala794Gly did not show any significant association with histopathologic characteristics of the tumors, though Ala794Gly was slightly more frequent among unselected cases with lymph node involvement. Our results do not support the role of NuMA variants as breast cancer susceptibility alleles.

  1. Comprehensive analysis of NuMA variation in breast cancer

    Directory of Open Access Journals (Sweden)

    Aittomäki Kristiina

    2008-03-01

    Full Text Available Abstract Background A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. Methods In order to evaluate the NuMa gene for breast cancer susceptibility, we have here screened the entire coding region and exon-intron boundaries of NuMa in 92 familial breast cancer patients and constructed haplotypes of the identified variants. Five missense variants were further screened in 341 breast cancer cases with a positive family history and 368 controls. We examined the frequency of Ala794Gly in an extensive series of familial (n = 910 and unselected (n = 884 breast cancer cases and controls (n = 906, with a high power to detect the suggested breast cancer risk. We also tested if the variant is associated with histopathologic features of breast tumors. Results Screening of NuMA resulted in identification of 11 exonic variants and 12 variants in introns or untranslated regions. Five missense variants that were further screened in breast cancer cases with a positive family history and controls, were each carried on a unique haplotype. None of the variants, or the haplotypes represented by them, was associated with breast cancer risk although due to low power in this analysis, very low risk alleles may go unrecognized. The NuMA Ala794Gly showed no difference in frequency in the unselected breast cancer case series or familial case series compared to control cases. Furthermore, Ala794Gly did not show any significant association with histopathologic characteristics of the tumors, though Ala794Gly was slightly more frequent among unselected cases with lymph node involvement. Conclusion Our results do not support the role of NuMA variants as breast cancer susceptibility alleles.

  2. Clot dynamics and mortality: The MA-R ratio.

    Science.gov (United States)

    Savage, Stephanie A; Zarzaur, Ben L; Pohlman, Timothy H; Brewer, Brian L; Magnotti, Louis J; Croce, Martin A; Lim, Garrett H; Martin, Ali C

    2017-10-01

    The coagulopathy of trauma, illustrated by a short R-time, is common and well understood. The physiology behind this may be early thrombin burst with rapid clot formation. Rapid consumption of fibrinogen, however, may result in weak clot and substrate depletion, resulting in low MA. While these characteristics are interesting, utilizing thromboelastography (TEG) to identify those at risk of subsequent bleeding diathesis, especially in those who do not demonstrate early signs of physiologic derangement, is challenging. We have developed a novel ratio utilizing TEG values to describe patients at specific risk of traumatic coagulopathy. The purpose of this study was to create a single TEG value, which would reflect both the hypercoagulability and hypocoagulability of TIC. We hypothesized that this ratio, at admission, would be indicative of TIC and predictive of both blood product transfusion volumes and subsequent mortality. Patients admitted via the highest activation criteria at one of two Level I trauma centers were included if they received at least 1 unit of packed red blood cells in the first 24 hours of admission. The admission TEG was collected, and a ratio was calculated by dividing the MA by the R-time (MA-R). MA-R quartiles were developed, and multivariable logistic regression was utilized to determine odds of mortality. Three hundred thirty patients with admission TEG were included. In all patients, median age was 35 years (interquartile range, 25-54 years), Injury Severity Score (ISS) was 20 (interquartile range, 13-29), 76% were male, and 43% had penetrating trauma. The MA-R groups were based on quartiles. Multivariable analysis, controlling for mechanism of injury, ISS, and admission pH, showed that increasing ratios were associated with decreased odds of death. The lowest MA-R ratios were also significantly associated with higher ISS, higher rates of blunt injury, and higher plasma utilization without a significant difference in packed red blood cell

  3. Teknisk Ståbi

    DEFF Research Database (Denmark)

    Teknisk Ståbi er de bygningsprojekterendes og entreprenørers håndbog. Den dækker matematik, fysik, statestik, laster og sikkerhed samt beggematerialerne: beton, stål, træ, murværk, letbeton, glas og endelig fundering. Denne udgave er en næsten totalrevision, baseret på de nye Eurocodes, der afløs...

  4. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Eligibility to elect an MA plan for special needs..., and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA plan, or...

  5. Cambios del N del suelo en maíz continuo y rotaciones soja - maíz

    OpenAIRE

    Conti, Marta Elvira; Palma, Rosa Martha; Arrigo, Nilda Marta; Marelli, Hugo Juan

    1997-01-01

    p.277-280 Muchas investigaciones han establecido que el cultivo de soja incrementa el contenido de nitrógeno en el suelo, quedando disponible para el subsiguiente cultivo de maíz. Resultados opuestos, han demostrado que la extracción de N por el cultivo de soja es mayor que el aporte del mismo por fijación, dando un balance negativo para el sistema suelo-planta que conduce a una pérdida neta de N. Para determinar las causas del comportamiento observado en el cultivo de maíz posterior al de...

  6. Circuit models and three-dimensional electromagnetic simulations of a 1-MA linear transformer driver stage

    Directory of Open Access Journals (Sweden)

    D. V. Rose

    2010-09-01

    Full Text Available A 3D fully electromagnetic (EM model of the principal pulsed-power components of a high-current linear transformer driver (LTD has been developed. LTD systems are a relatively new modular and compact pulsed-power technology based on high-energy density capacitors and low-inductance switches located within a linear-induction cavity. We model 1-MA, 100-kV, 100-ns rise-time LTD cavities [A. A. Kim et al., Phys. Rev. ST Accel. Beams 12, 050402 (2009PRABFM1098-440210.1103/PhysRevSTAB.12.050402] which can be used to drive z-pinch and material dynamics experiments. The model simulates the generation and propagation of electromagnetic power from individual capacitors and triggered gas switches to a radially symmetric output line. Multiple cavities, combined to provide voltage addition, drive a water-filled coaxial transmission line. A 3D fully EM model of a single 1-MA 100-kV LTD cavity driving a simple resistive load is presented and compared to electrical measurements. A new model of the current loss through the ferromagnetic cores is developed for use both in circuit representations of an LTD cavity and in the 3D EM simulations. Good agreement between the measured core current, a simple circuit model, and the 3D simulation model is obtained. A 3D EM model of an idealized ten-cavity LTD accelerator is also developed. The model results demonstrate efficient voltage addition when driving a matched impedance load, in good agreement with an idealized circuit model.

  7. 78 FR 35756 - Drawbridge Operation Regulations; Charles River, Boston, MA

    Science.gov (United States)

    2013-06-14

    ... Regulations; Charles River, Boston, MA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from...) Bridge across the Charles River, mile 1.0, at Boston, Massachusetts. Under this temporary deviation the... Metropolitan District Commission (Craigie) Bridge, across the Charles River, mile 1.0, at Boston, Massachusetts...

  8. Faculty of Law: MaRBLe for Lawyers

    NARCIS (Netherlands)

    Akkermans, Bram; Bastiaens, Ellen; van Tilburg, Jonathan; van Merriënboer, Jeroen

    The Maastricht University Research Based Learning (MaRBLe) project offered a unique but challenging opportunity to the law faculty. Working with undergraduate (or bachelor) students on research was already part of regular, i.e. curricular, teaching activities, but the number of students and

  9. PuMA: the Porous Microstructure Analysis software

    Science.gov (United States)

    Ferguson, Joseph C.; Panerai, Francesco; Borner, Arnaud; Mansour, Nagi N.

    2018-01-01

    The Porous Microstructure Analysis (PuMA) software has been developed in order to compute effective material properties and perform material response simulations on digitized microstructures of porous media. PuMA is able to import digital three-dimensional images obtained from X-ray microtomography or to generate artificial microstructures. PuMA also provides a module for interactive 3D visualizations. Version 2.1 includes modules to compute porosity, volume fractions, and surface area. Two finite difference Laplace solvers have been implemented to compute the continuum tortuosity factor, effective thermal conductivity, and effective electrical conductivity. A random method has been developed to compute tortuosity factors from the continuum to rarefied regimes. Representative elementary volume analysis can be performed on each property. The software also includes a time-dependent, particle-based model for the oxidation of fibrous materials. PuMA was developed for Linux operating systems and is available as a NASA software under a US & Foreign release.

  10. The Launch of the MA-6, Friendship 7

    Science.gov (United States)

    1962-01-01

    The launch of the MA-6, Friendship 7, on February 20, 1962. Boosted by the Mercury-Atlas vehicle, a modified Atlas Intercontinental Ballistic Missile (ICBM), Friendship 7 was the first U.S. marned orbital flight and carried Astronaut John H. Glenn into orbit. Astronaut Glenn became the first American to orbit the Earth.

  11. Second Generation Dutch Pulsar Machine - PuMa-II

    NARCIS (Netherlands)

    Karuppusamy, Ramesh; Stappers, Ben; Slump, Cornelis H.; van der Klis, Michiel

    2004-01-01

    The Second Generation Pulsar Machine (PuMa- II) is under development for the Westerbork Synthesis Radio Telescope. This is a summary of th e system design and architecture. We show that state of the art pulsar research is possible with commercially available hardware components. This approach

  12. MA-23-6000: underwater bilateral servo master slave manipulator

    International Nuclear Information System (INIS)

    Vertut, Jean

    The different types of manipulators, recent data on their dexterity and the underwater work possible with servo master slave manipulators are reviewed. The general specifications of the manipulator MA 23-6000 designed for the machine ERIC II are given [fr

  13. 77 FR 1503 - Massasoit National Wildlife Refuge, Plymouth, MA

    Science.gov (United States)

    2012-01-10

    ... Fish and Wildlife Service Massasoit National Wildlife Refuge, Plymouth, MA AGENCY: Fish and Wildlife... Wildlife Refuge (the refuge, NWR) in Plymouth, Massachusetts. We provide this notice in compliance with our... conduct detailed planning on this refuge. DATES: We will announce opportunities for public input...

  14. DVD-d. Shrek Kolmas; Ma olen legend / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2008-01-01

    Lühiarvustused USA 2007.a. filmidele : animafilm "Shrek Kolmas" ("Shrek the Third", režissöörid Chris Miller, Raman Hui) ja ulmefilm "Ma olen legend" ("I Am Legend"; režissöör Francis Lawrence)

  15. Anti-osteoporosis effect of Cistanche deserticola Ma extract in ...

    African Journals Online (AJOL)

    Anti-osteoporosis effect of Cistanche deserticola Ma extract in ovariectomized rats. ... Bone mineral density (BMD) of L4 vertebrae and right femur of rats was estimated, The length of each femur was measured, and biochemical analysis of serum and urine specimens were performed. Results: CDME dose-dependently ...

  16. 1420 Ma diabasic intrusives from the Mesoproterozoic Singhora ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 120; Issue 2. 1420 Ma diabasic intrusives from the Mesoproterozoic Singhora Group, Chhattisgarh ... Zr, Y and Nb ternary diagrams plot in the fields of within plate basalt. Selected HFSE ratios indicate a non-plume source with crustal assimilation/sediment mixing.

  17. Thesis Writing Challenges for Non-Native MA Students

    Science.gov (United States)

    Sadeghi, Karim; Shirzad Khajepasha, Arash

    2015-01-01

    Writing in a second (L2)/foreign language is generally a challenging activity, and writing an MA thesis, as an example of academic enterprise, can be daunting when done in a language in which the writer is not fully competent. The challenge such a genre of writing poses for L2 writers has not been properly addressed. To fill in the gap in this…

  18. Predicting Sediment Thickness on Vanished Ocean Crust Since 200 Ma

    Science.gov (United States)

    Dutkiewicz, A.; Müller, R. D.; Wang, X.; O'Callaghan, S.; Cannon, J.; Wright, N. M.

    2017-12-01

    Tracing sedimentation through time on existing and vanished seafloor is imperative for constraining long-term eustasy and for calculating volumes of subducted deep-sea sediments that contribute to global geochemical cycles. We present regression algorithms that incorporate the age of the ocean crust and the mean distance to the nearest passive margin to predict sediment thicknesses and long-term decompacted sedimentation rates since 200 Ma. The mean sediment thickness decreases from ˜220 m at 200 Ma to a minimum of ˜140 m at 130 Ma, reflecting the replacement of old Panthalassic ocean floor with young sediment-poor mid-ocean ridges, followed by an increase to ˜365 m at present-day. This increase reflects the accumulation of sediments on ageing abyssal plains proximal to passive margins, coupled with a decrease in the mean distance of any parcel of ocean crust to the nearest passive margin by over 700 km, and a doubling of the total passive margin length at present-day. Mean long-term sedimentation rates increase from ˜0.5 cm/ky at 160 Ma to over 0.8 cm/ky today, caused by enhanced terrigenous sediment influx along lengthened passive margins, superimposed by the onset of ocean-wide carbonate sedimentation. Our predictive algorithms, coupled to a plate tectonic model, provide a framework for constraining the seafloor sediment-driven eustatic sea-level component, which has grown from ˜80 to 210 m since 120 Ma. This implies a long-term sea-level rise component of 130 m, partly counteracting the contemporaneous increase in ocean basin depth due to progressive crustal ageing.

  19. Component geochronology in the polyphase ca. 3920 Ma Acasta Gneiss

    Science.gov (United States)

    Mojzsis, Stephen J.; Cates, Nicole L.; Caro, Guillaume; Trail, Dustin; Abramov, Oleg; Guitreau, Martin; Blichert-Toft, Janne; Hopkins, Michelle D.; Bleeker, Wouter

    2014-01-01

    The oldest compiled U–Pb zircon ages for the Acasta Gneiss Complex in the Northwest Territories of Canada span about 4050–3850 Ma; yet older ca. 4200 Ma xenocrystic U–Pb zircon ages have also been reported for this terrane. The AGC expresses at least 25 km2 of outcrop exposure, but only a small subset of this has been documented in the detail required to investigate a complex history and resolve disputes over emplacement ages. To better understand this history, we combined new ion microprobe235,238U–207,206Pb zircon geochronology with whole-rock and zircon rare earth element compositions ([REE]zirc), Ti-in-zircon thermometry (Tixln) and 147Sm–143Nd geochronology for an individual subdivided ∼60 cm2 slab of Acasta banded gneiss comprising five separate lithologic components. Results were compared to other variably deformed granitoid-gneisses and plagioclase-hornblende rocks from elsewhere in the AGC. We show that different gneissic components carry distinct [Th/U]zirc vs. Tixln and [REE]zirc signatures correlative with different zircon U–Pb age populations and WR compositions, but not with 147Sm–143Nd isotope systematics. Modeled  [REE] from lattice-strain theory reconciles only the ca. 3920 Ma zircons with the oldest component that also preserves strong positive Eu∗ anomalies. Magmas which gave rise to the somewhat older (inherited) ca. 4020 Ma AGC zircon age population formed at ∼IW (iron–wüstite) to Ma emplacement age for the AGC is contemporaneous with bombardment of the inner solar system. Analytical bombardment simulations show that crustal re-working from the impact epoch potentially affected the precursors to the Acasta gneisses.

  20. Mass and Reliability Source (MaRS) Database

    Science.gov (United States)

    Valdenegro, Wladimir

    2017-01-01

    The Mass and Reliability Source (MaRS) Database consolidates components mass and reliability data for all Oribital Replacement Units (ORU) on the International Space Station (ISS) into a single database. It was created to help engineers develop a parametric model that relates hardware mass and reliability. MaRS supplies relevant failure data at the lowest possible component level while providing support for risk, reliability, and logistics analysis. Random-failure data is usually linked to the ORU assembly. MaRS uses this data to identify and display the lowest possible component failure level. As seen in Figure 1, the failure point is identified to the lowest level: Component 2.1. This is useful for efficient planning of spare supplies, supporting long duration crewed missions, allowing quicker trade studies, and streamlining diagnostic processes. MaRS is composed of information from various databases: MADS (operating hours), VMDB (indentured part lists), and ISS PART (failure data). This information is organized in Microsoft Excel and accessed through a program made in Microsoft Access (Figure 2). The focus of the Fall 2017 internship tour was to identify the components that were the root cause of failure from the given random-failure data, develop a taxonomy for the database, and attach material headings to the component list. Secondary objectives included verifying the integrity of the data in MaRS, eliminating any part discrepancies, and generating documentation for future reference. Due to the nature of the random-failure data, data mining had to be done manually without the assistance of an automated program to ensure positive identification.

  1. High Resolution Anatomic and Elastographic Transrectal Ultrasound for Improved Diagnosis of Prostate Cancer

    Science.gov (United States)

    2008-08-01

    applications." Norbert Wiener : Collected Works vol. III, P. Masani, Ed., Cambridge, MA: MIT Press: 63-94. Kuan, D., A. Sawchuk, et al. (1985...Loupas, McDicken et al. 1989), the Wiener filter (Kailath 1976), the SRAD proposed by Yu and Acton (Yu and Acton 2002), and a novel stochastically...on Ultrasonics Ferroelectrics & Frequency Control 39: 262-267. Kailath, T. (1976). "Equations of Wiener -Hopf type in filtering theory and related

  2. The Danish St. Croix Project

    DEFF Research Database (Denmark)

    J. Douma, Michael; Rasmussen, Anders Bo

    2014-01-01

    Working from previously unknown sources in Danish archives, this article establishes for the first time the important role that the island of St. Croix played in the Lincoln Administration’s considerations on colonizing African Americans abroad. The paper argues that U.S. Secretary of State Willi...... H. Seward, commonly viewed as an anti-colonizationist, was at least a mild proponent of colonization in its earliest stages. The paper demonstrates further that in the summer of 1862 the St. Croix colonization project was an important stepping stone in the Lincoln administration’s legal...

  3. maņa integrāļa definīcija un eksistences nosacījumi piemēros

    OpenAIRE

    Paudere, Kristīne

    2009-01-01

    Bakalaura darbs ir veltīts Rīmaņa integrāļa jēdzienam. Uzmanība tiek pievērsta integrāļa definīcijai ar integrālajām summām un Darbū summām, kā arī integrāļa eksistences nosacījumiem. Katras tēmas ietvaros tiek izklāstīti teorētiskie pamati un apskatīti daudzi uzdevumi, kuri palīdz labāk saprast teorētisko materiālu. Atslēgvārdi: Rīmaņa integrālis, integrālā summa, Darbū summas, integrāļa eksistences nosacījumi

  4. Modalization as Persuasion in the Discourse of MA Dissertation Introductions

    Directory of Open Access Journals (Sweden)

    Elaine Cristine Fernandes da Silva

    2011-07-01

    Full Text Available This article highlights some basic aspects of the Systemic Functional Grammar described by Halliday (1984 and 1994]and his followers; we intend to analyze the modalization in the construction of discursive strategies in MA dissertation introductions. The corpus is composed of 10 MA dissertation introductions with emphasis in the arguments for the research, which are reinforced by the constant occurrence of NECESSITY JUSTIFICATION and AIMS OF THE RESEARCH. We adopt the methodology called case study; therefore we analyze a specifi c discourse community and, for this, we used the software Wordsmith Tools (Scott, 1996, a device that allowed us to analyze in a detailed manner the lexical items from the texts. The analysis of our corpus showed that, at the Program in Applied Linguistics and Language Studies of PUC-SP, modalization is frequently used through modal verbs in the excerpts called NECESSITY JUSTIFICATION and AIMS OF THE RESEARCH.

  5. Operation with 1 MA Plasma Current in EAST

    International Nuclear Information System (INIS)

    Qian Jinping; Gong Xianzu; Li Jiangang; Wan Baonian; Ling Bili; Shen Biao; Ti Ang; Zhong Guoqiang; Lin Shiyao; Chang Jiafeng; Wang Huazhong

    2011-01-01

    Discharge with a plasma current of 1 MA at a line-averaged density of 1.8 x 10 19 m -3 was realized in EAST, a fully superconducting tokamak. The key issues to achieve the discharge with 1 MA plasma current include both early shaping and LHCD assistance during start-up phase to extend the voltage margin of poloidal field (PF) coils for easier plasma control, an optimization of the control methodology for PF coils to avoid over-current fault and a very good wall condition. A better wall condition was achieved mainly by extensive Lithium coating. Both stationary H-mode and diverted plasma discharge of 100 s were also obtained.

  6. MA nuclear data measurement with lead slowing-down spectrometers

    International Nuclear Information System (INIS)

    Kobayashi, Katsuhei

    2000-01-01

    This paper reviews the minor actinide (MA) nuclear data measured with lead slowing-down spectrometers. The Kyoto University Lead Slowing-down Spectrometer (KULS) at the Research Reactor Institute, Kyoto University has been applied to the measurements of (1) the fission cross sections of Np-237, Am-241, Am-242m and Am-243 in the energy range from 0.1 eV to 10 keV and (2) the capture cross section of Np-237 at energies between 0.01 eV and 1 keV. The results are compared with the existing experimental and the evaluated nuclear data (ENDF/B-VI, JENDL-3.2 and JEF-2.2). The recent MA nuclear data, which were measured with the Rensselaer Intense Neutron Spectrometer (RINS) at the Rensselaer Polytechnic Institute and the spectrometer at the Kurchatov Institute, are also introduced. (author)

  7. MaGnET: Malaria Genome Exploration Tool.

    Science.gov (United States)

    Sharman, Joanna L; Gerloff, Dietlind L

    2013-09-15

    The Malaria Genome Exploration Tool (MaGnET) is a software tool enabling intuitive 'exploration-style' visualization of functional genomics data relating to the malaria parasite, Plasmodium falciparum. MaGnET provides innovative integrated graphic displays for different datasets, including genomic location of genes, mRNA expression data, protein-protein interactions and more. Any selection of genes to explore made by the user is easily carried over between the different viewers for different datasets, and can be changed interactively at any point (without returning to a search). Free online use (Java Web Start) or download (Java application archive and MySQL database; requires local MySQL installation) at http://malariagenomeexplorer.org joanna.sharman@ed.ac.uk or dgerloff@ffame.org Supplementary data are available at Bioinformatics online.

  8. Portraits de Maîtres offerts à Olga Weijers

    NARCIS (Netherlands)

    Teeuwen, M.J.; Angotti, C.; Brînzei, M.

    2013-01-01

    En 2011, le répertoire d’Olga Weijers, Le travail intellectuel à la faculté des arts de Paris : textes et maîtres (ca. 1200-1500), en neuf volumes, est arrivé à son terme. Cet instrument de travail a également inauguré la collection Studia Artistarum dans laquelle Olga Weijers a accueilli ces quinze

  9. Blended learning and postgraduate skills: rethinking MA History

    OpenAIRE

    McCormack, Matthew; Hanley-Smith, Natalie

    2015-01-01

    This study focuses on the implications of blended learning for taught postgraduate education. It takes as its focus the pilot year of the MA History at the University of Northampton, which had been redesigned to blend online and face-to-face delivery. By employing a student researcher to canvass students’ views, the project evaluates the implications of the delivery mode for the specific skills associated with the discipline of History. As well as evaluating this particular programme, the pro...

  10. Consideration of QRS complex in addition to ST-segment abnormalities in the estimation of the "risk region" during acute anterior or inferior myocardial infarction.

    Science.gov (United States)

    Vervaat, F E; Bouwmeester, S; van Hellemond, I E G; Wagner, G S; Gorgels, A P M

    2014-01-01

    The myocardial area at risk (MaR) is an important aspect in acute ST-elevation myocardial infarction (STEMI). It represents the myocardium at the onset of the STEMI that is ischemic and could become infarcted if no reperfusion occurs. The MaR, therefore, has clinical value because it gives an indication of the amount of myocardium that could potentially be salvaged by rapid reperfusion therapy. The most validated method for measuring the MaR is (99m)Tc-sestamibi SPECT, but this technique is not easily applied in the clinical setting. Another method that can be used for measuring the MaR is the standard ECG-based scoring system, Aldrich ST score, which is more easily applied. This ECG-based scoring system can be used to estimate the extent of acute ischemia for anterior or inferior left ventricular locations, by considering quantitative changes in the ST-segment. Deviations in the ST-segment baseline that occur following an acute coronary occlusion represent the ischemic changes in the transmurally ischemic myocardium. In most instances however, the ECG is not available at the very first moments of STEMI and as times passes the ischemic myocardium becomes necrotic with regression of the ST-segment deviation along with progressive changes of the QRS complex. Thus over the time course of the acute event, the Aldrich ST score would be expected to progressively underestimate the MaR, as was seen in studies with SPECT as gold standard; anterior STEMI (r=0.21, p=0.32) and inferior STEMI (r=0.17, p=0.36). Another standard ECG-based scoring system is the Selvester QRS score, which can be used to estimate the final infarct size by considering the quantitative changes in the QRS complex. Therefore, additional consideration of the Selvester QRS score in the acute phase could potentially provide the "component" of infarcted myocardium that is missing when the Aldrich ST score alone is used to determine the MaR in the acute phase, as was seen in studies with SPECT as gold

  11. Les particules illocutoires, variable d’ajustement de la traduction sous-titrante au cinéma

    Directory of Open Access Journals (Sweden)

    Ève Vayssière

    2010-12-01

    Full Text Available Die illokutiven Partikel fungieren als Anpassungsvariable, die beim Übersetzungsakt zur Untertitelung von Filmen entweder weggelassen werden oder erscheinen. Wenn sie einfach gelöscht werden, ergeben sich weder grammatikalische Störungen noch Informationsverlust. Das Auftauchen dieser Partikel in den deutschen Untertiteln zeigt jedoch, wie wichtig sie sind: Als Partikel der Oralität tragen sie zur Idiomatizität bei.Les particules illocutoires sont des variables d’ajustement lors de l’acte de traduction sous-titrante au cinéma, elles peuvent être supprimées sans que cela occasionne de dysfonctionnement grammatical et elles disparaissent lors de la traduction en français sans que cela occasionne une perte d’informations. Leur apparition dans les sous-titres allemands montre néanmoins leur importance : particules de l’oralité, elles sont vecteur d’« idiomaticité ».

  12. 1st quarterly report 1977

    International Nuclear Information System (INIS)

    1977-06-01

    The present report describes the activities carried out in the 1st quarter of 1977 at the Gesellschaft fuer Kernforschung in Karlsruhe or on its behalf in the framework of the fast breeder project (PSB). The problems and main results of the partial projects fuel rod development, materials testing, reactor physics, reactor safety and reactor technology are presented. (RW) [de

  13. Methylphenidatinduceret ST-elevations-myokardieinfarkt

    DEFF Research Database (Denmark)

    Ruwald, Martin Huth; Ruwald, Anne-Christine Huth; Tønder, Niels

    2012-01-01

    Adult attention deficit and hyperkinetic disorder (ADHD) is increasingly diagnosed and treated with methylphenidate. We present the case of an 20 year-old man, who was diagnosed with ADHD and suffered a ST elevation acute myocardial infarction due to coronary vasospasm related to an overdose...

  14. Essential role for the dimerization domain of NuMA-RARalpha in its oncogenic activities and localization to NuMA sites within the nucleus.

    Science.gov (United States)

    Dong, Shuo; Qiu, Jihui; Stenoien, David L; Brinkley, William R; Mancini, Michael A; Tweardy, David J

    2003-02-13

    Nuclear mitotic apparatus protein-retinoic acid receptor alpha (NuMA-RARalpha) is the fourth of five fusion proteins identified in acute promyelocytic leukemia (APL) patients. The molecular basis for its oncogenic activity has not been delineated. In gel-shift assays, NuMA-RARalpha bound to retinoic acid response elements (RAREs) both as a homodimer and as a heterodimer with RXRalpha. The binding profile of NuMA-RARalpha to a panel of RAREs was very similar to PML-RARalpha and PLZF-RARalpha. In transient transfection assays using HepG2 cells, NuMA-RARalpha inhibited wild-type RARalpha transcriptional activity, while it augmented STAT3 transcriptional activity. In GST-pull down experiments, NuMA-RARalpha formed a complex with the corepressor SMRT, was released from the NuMA-RARalpha/SMRT complexes by all-trans retinoic acid (ATRA) at 10(-7)-10(-6) M and became associated with the coactivator TRAM-1 at 10(-8) M ATRA. Studies comparing NuMA-RARalpha with NuMA-RARalpha(deltaCC) demonstrated that the dimerization or alpha-helical coiled-coil domain of NuMA was required for homodimer formation, transcriptional repression of wild-type RARalpha, transcriptional activation of STAT3, and stability of the NuMA-RARalpha/SMRT complex. Confocal fluorescent microscopy of HeLa cells was performed following transient expression of cyan fluorescent protein (CFP)-tagged proteins and incubation of cells with or without ATRA. Within the nucleus, CFP-NuMA-RARalpha exhibited a speckled pattern identical to that observed in cells transfected with CFP-NuMA. Furthermore, CFP-NuMA-RARalpha colocalized with yellow fluorescent protein-tagged (YFP)-NuMA. In contrast, CFP-NuMA-RARalpha(deltaCC) exhibited a diffuse granular pattern within the nucleus, similar to RARalpha. These results indicate that the dimerization domain of NuMA-RARalpha is critical for each of the known oncogenic activities of NuMA fusion proteins as well as its sequestration to nuclear sites normally occupied by NuMA and is

  15. Neuroprotective Effect of Gui Zhi (Ramulus Cinnamomi on Ma Huang- (Herb Ephedra- Induced Toxicity in Rats Treated with a Ma Huang-Gui Zhi Herb Pair

    Directory of Open Access Journals (Sweden)

    Fang-hao Zheng

    2015-01-01

    Full Text Available Herb Ephedra (Ma Huang in Chinese and Ramulus Cinnamomi (Gui Zhi in Chinese are traditional Chinese herbs, often used together to treat asthma, nose and lung congestion, and fever with anhidrosis. Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted. However, Gui Zhi extract has been reported to decrease spontaneous activity in rats and exert anti-inflammatory and neuroprotective effects. The present study explored the possible inhibitory effect of Gui Zhi on Ma Huang-induced neurotoxicity in rats when the two herbs were used in combination. All Ma Huang and Ma Huang-Gui Zhi herb pair extracts were prepared using methods of traditional Chinese medicine and were normalized based on the ephedrine content. Two-month-old male Sprague-Dawley rats (n=6 rats/group were administered Ma Huang or the Ma Huang-Gui Zhi herb pair extracts for 7 days (ephedrine = 48 mg/kg, and locomotor activity was measured. After 7 days, oxidative damage in the prefrontal cortex was measured. Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang. The results of this study demonstrate the neuroprotective potential of Gui Zhi in Ma Huang-induced hyperactivity and oxidative damage in the prefrontal cortex of rats when used in combination.

  16. 78 FR 20341 - Proposed Flood Hazard Determinations

    Science.gov (United States)

    2013-04-04

    .... Town of Sudbury Flynn Building, 278 Old Sudbury Road, Sudbury, MA 01776. Town of Tewksbury Town Hall... Concord River Watershed Worcester County and Middlesex County, Massachusetts (All Jurisdictions) Maps..., Lowell, MA 01852. City of Marlborough City Hall, 140 Main Street, Marlborough, MA 01752. Town of Acton...

  17. ImpersoNations: cinéma national, imaginaires historiques et nouveau cinéma européen

    NARCIS (Netherlands)

    Elsaesser, T.

    2013-01-01

    La question du capital culturel propre à la diversité linguistique de l’Europe reste entière. Quels sont les avantages et les inconvénients de cet éventail de langues dans le cinéma? Les films, quand ils franchissent les frontières, sont souvent doublés. Or, comme un bon jeu d’acteur représente une

  18. Opioidergic orofacial antinociception induced by electroacupuncture at acupoint St36

    Directory of Open Access Journals (Sweden)

    R.T. Almeida

    2008-07-01

    Full Text Available The participation of opioids in the antinociceptive effect of electroacupuncture was evaluated in terms of nociception produced by thermal stimuli applied to the face of male Wistar rats, weighing 180-230 g. Electrical stimulation (bipolar and asymmetric square wave with 0.5 mA intensity for 20 min of acupoint St36, located in the anterior tibial muscle 10 mm distal to the knee joint, induced antinociception in the present model, which was maintained for 150 min. Acupoint LI4, located in the junction of the first and second metacarpal bones, did not achieve antinociception at any frequency studied (5 Hz: 1.7 ± 0.1; 30 Hz: 1.8 ± 0.1; 100 Hz: 1.7 ± 0.1 vs 1.4 ± 0.2. The antinociception obtained by stimulation of acupoint St36 was only achieved when high frequency 100 Hz (3.0 ± 0.2 vs 1.0 ± 0.1 was used, and not with 5 or 30 Hz (1.2 ± 0.2 and 0.7 ± 0.1 vs 1.0 ± 0.1. The antinociceptive effect of acupuncture occurred by opioid pathway activation, since naloxone (1 and 2 mg/kg, subcutaneously antagonized it (1.8 ± 0.2 and 1.7 ± 0.2 vs 3.0 ± 0.1.

  19. Efficacy and safety of two polyherbal combinations: E-MA-H and E-MA-HP in male sexual dysfunction.

    Science.gov (United States)

    Kulkarni, Mugdha P; Shinde, Bhakti S; Chaudhari, Manoj Kumar V; Avhad, Ganesh M; Pensalwar, Shrikant V; Prasad, B S V; Deshpande, Manoj Kumar M; Rosenbloom, Richard A

    2011-01-01

    Efficacy and safety of 2 herbal products--E-MA-H at 2 dose levels, low (HLD) and high (HHD), and E-MA-HP (HP) capsules--versus placebo (PL) was evaluated in subjects with male sexual dysfunction. Males aged 21-60 with erectile dysfunction, premature ejaculation, or other form of sexual dysfunction were studied in this triple-blind, randomized, placebo-controlled, parallel-groups trial. Subjects received any one of the following 4 interventions: E-MA-H 2 capsules at night (HLD) for 60 days; E-MA-H 2 capsules twice daily for 30 days, followed by 2 capsules at night for 30 days (HHD); E-MA-HP (HP) 2 capsules twice daily for 60 days; or placebo (PL) 2 capsules twice daily for 60 days. All dosage regimens were standardized to 2 capsules twice daily by using 2 matching placebo capsules as the morning dose for HLD and on days 31-60 for HHD. Efficacy outcome measures were the international index of erectile function; index for premature ejaculation; erectile dysfunction inventory of treatment satisfaction; subjects' and investigators' global assessment. Safety was assessed through adverse events; hematology; blood chemistry. Of 148 subjects enrolled, 1 was excluded from analysis; data on the intention-to-treat population of 147 (PL = 36, HLD = 38, HHD = 37, HP = 36) were analyzed. There was a significant (P HP (18.55 ± 1.36) compared with PL (6.83 ± 1.52). The same pattern was seen with increase in index for premature ejaculation scores: HLD (9.68 ± 1.17), HHD (10.27 ± 1.05), HP (11.36 ± 1.20) versus PL (3.77 ± 1.04). There was no significant difference in effect among the active treatment groups. The incidence of adverse events was similar in all the groups. Laboratory evaluations did not show any clinically significant abnormality in any of the groups. Treatment with HLD, HHD, and HP is well tolerated, and more effective than placebo (P < 0.01), in subjects with erectile dysfunction, premature ejaculation, and other forms of sexual dysfunction.

  20. Team Danmarks støttekoncept

    DEFF Research Database (Denmark)

    Storm, Rasmus K.

    Evaluering af Team Danmarks støttekoncept 2005-2008 med omfattende analyser af Team Danmarks virke, dets støttekoncept og de samarbejdsrelationer med specialforbund, udøvere, politisk valgte ledere, trænere mv., som udmøntningen af støttekonceptet forudsætter. Herunder analyse af...

  1. The Banana Fruit SINA Ubiquitin Ligase MaSINA1 Regulates the Stability of MaICE1 to be Negatively Involved in Cold Stress Response

    OpenAIRE

    Zhong-Qi Fan; Jian-Ye Chen; Jian-Fei Kuang; Wang-Jin Lu; Wei Shan

    2017-01-01

    The regulation of ICE1 protein stability is important to ensure effective cold stress response, and is extensively studied in Arabidopsis. Currently, how ICE1 stability in fruits under cold stress is controlled remains largely unknown. Here, we reported the possible involvement of a SEVEN IN ABSENTIA (SINA) ubiquitin ligase MaSINA1 from banana fruit in affecting MaICE1 stability. MaSINA1 was identified based on a yeast two-hybrid screening using MaICE1 as bait. Further yeast two-hybrid, pull-...

  2. Isolation of MA-ACS Gene Family and Expression Study of MA-ACS1 Gene in Musa acuminata Cultivar Pisang Ambon Lumut

    Directory of Open Access Journals (Sweden)

    LISTYA UTAMI KARMAWAN

    2009-03-01

    Full Text Available Musa acuminata cultivar pisang ambon lumut is a native climacteric fruit from Indonesia. Climacteric fruit ripening process is triggered by the gaseous plant hormone ethylene. The rate limiting enzyme involved in ethylene biosynthesis is ACC synthase (ACS which is encoded by ACS gene family. The objective of this study is to identify MA-ACS gene family in M. acuminata cultivar pisang ambon lumut and to study the MA-ACS1 gene expression. The result showed that there were nine M. acuminata ACS gene family members called MA-ACS1–9. Two of them (MA-ACS1 and MA-ACS2 were assessed using reverse transcriptase PCR (RT-PCR for gene expression study and it was only MA-ACS1 correlated with fruit ripening. The MA-ACS1 gene fragment has been successfully isolated and characterized and it has three introns, four exons, and one stop codon. It also shows highest homology with MACS1 gene from M. acuminata cultivar Hsian Jien Chiao (GenBank accession number AF056164. Expression analysis of MA-ACS1 using quantitative PCR (qPCR showed that MA-ACS1 gene expression increased significantly in the third day, reached maximum at the fifth day, and then decreased in the seventh day after harvesting. The qPCR expression analysis result correlated with the result of physical analysis during fruit ripening.

  3. SDSS-IV/MaNGA: SPECTROPHOTOMETRIC CALIBRATION TECHNIQUE

    International Nuclear Information System (INIS)

    Yan, Renbin; Sánchez-Gallego, José R.; Tremonti, Christy; Bershady, Matthew A.; Eigenbrot, Arthur; Wake, David A.; Law, David R.; Schlegel, David J.; Bundy, Kevin; Drory, Niv; MacDonald, Nicholas; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Hogg, David W.; Cherinka, Brian; Gunn, James E.; Harding, Paul; Sánchez, Sebastian F.

    2016-01-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600–10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range

  4. SDSS-IV/MaNGA: SPECTROPHOTOMETRIC CALIBRATION TECHNIQUE

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Renbin; Sánchez-Gallego, José R. [Department of Physics and Astronomy, University of Kentucky, 505 Rose St., Lexington, KY 40506-0057 (United States); Tremonti, Christy; Bershady, Matthew A.; Eigenbrot, Arthur; Wake, David A. [Department of Astronomy, University of Winsconsin-Madison, 475 N. Charter Street, Madison, WI 53706-1582 (United States); Law, David R. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Schlegel, David J. [Physics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720-8160 (United States); Bundy, Kevin [Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Drory, Niv [McDonald Observatory, Department of Astronomy, University of Texas at Austin, 1 University Station, Austin, TX 78712-0259 (United States); MacDonald, Nicholas [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Bizyaev, Dmitry [Apache Point Observatory, P.O. Box 59, sunspot, NM 88349 (United States); Blanc, Guillermo A. [Departamento de Astronomía, Universidad de Chile, Camino el Observatorio 1515, Las Condes, Santiago (Chile); Blanton, Michael R.; Hogg, David W. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Cherinka, Brian [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, Ontario M5S 3H4 (Canada); Gunn, James E. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Harding, Paul [Department of Astronomy, Case Western Reserve University, Cleveland, OH 44106 (United States); Sánchez, Sebastian F., E-mail: yanrenbin@uky.edu [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, A.P. 70-264, 04510 Mexico D.F. (Mexico); and others

    2016-01-15

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600–10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range.

  5. 46 CFR 308.306 - Second Seamen's War Risk Policy, Form MA-242.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Second Seamen's War Risk Policy, Form MA-242. 308.306... RISK INSURANCE Second Seamen's War Risk Insurance § 308.306 Second Seamen's War Risk Policy, Form MA-242. (a) The standard form of Second Seamen's War Risk Policy Form MA-242, may be obtained from the...

  6. Cell cycle-dependent SUMO-1 conjugation to nuclear mitotic apparatus protein (NuMA)

    International Nuclear Information System (INIS)

    Seo, Jae Sung; Kim, Ha Na; Kim, Sun-Jick; Bang, Jiyoung; Kim, Eun-A; Sung, Ki Sa; Yoon, Hyun-Joo; Yoo, Hae Yong; Choi, Cheol Yong

    2014-01-01

    Highlights: •NuMA is modified by SUMO-1 in a cell cycle-dependent manner. •NuMA lysine 1766 is the primary target site for SUMOylation. •SUMOylation-deficient NuMA induces multiple spindle poles during mitosis. •SUMOylated NuMA induces microtubule bundling. -- Abstract: Covalent conjugation of proteins with small ubiquitin-like modifier 1 (SUMO-1) plays a critical role in a variety of cellular functions including cell cycle control, replication, and transcriptional regulation. Nuclear mitotic apparatus protein (NuMA) localizes to spindle poles during mitosis, and is an essential component in the formation and maintenance of mitotic spindle poles. Here we show that NuMA is a target for covalent conjugation to SUMO-1. We find that the lysine 1766 residue is the primary NuMA acceptor site for SUMO-1 conjugation. Interestingly, SUMO modification of endogenous NuMA occurs at the entry into mitosis and this modification is reversed after exiting from mitosis. Knockdown of Ubc9 or forced expression of SENP1 results in impairment of the localization of NuMA to mitotic spindle poles during mitosis. The SUMOylation-deficient NuMA mutant is defective in microtubule bundling, and multiple spindles are induced during mitosis. The mitosis-dependent dynamic SUMO-1 modification of NuMA might contribute to NuMA-mediated formation and maintenance of mitotic spindle poles during mitosis

  7. Cell cycle-dependent SUMO-1 conjugation to nuclear mitotic apparatus protein (NuMA)

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Jae Sung; Kim, Ha Na; Kim, Sun-Jick; Bang, Jiyoung; Kim, Eun-A; Sung, Ki Sa [Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746 (Korea, Republic of); Yoon, Hyun-Joo [TissueGene Inc. 9605 Medical Center Dr., Rockville, MD 20850 (United States); Yoo, Hae Yong [Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710 (Korea, Republic of); Choi, Cheol Yong, E-mail: choicy@skku.ac.kr [Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746 (Korea, Republic of)

    2014-01-03

    Highlights: •NuMA is modified by SUMO-1 in a cell cycle-dependent manner. •NuMA lysine 1766 is the primary target site for SUMOylation. •SUMOylation-deficient NuMA induces multiple spindle poles during mitosis. •SUMOylated NuMA induces microtubule bundling. -- Abstract: Covalent conjugation of proteins with small ubiquitin-like modifier 1 (SUMO-1) plays a critical role in a variety of cellular functions including cell cycle control, replication, and transcriptional regulation. Nuclear mitotic apparatus protein (NuMA) localizes to spindle poles during mitosis, and is an essential component in the formation and maintenance of mitotic spindle poles. Here we show that NuMA is a target for covalent conjugation to SUMO-1. We find that the lysine 1766 residue is the primary NuMA acceptor site for SUMO-1 conjugation. Interestingly, SUMO modification of endogenous NuMA occurs at the entry into mitosis and this modification is reversed after exiting from mitosis. Knockdown of Ubc9 or forced expression of SENP1 results in impairment of the localization of NuMA to mitotic spindle poles during mitosis. The SUMOylation-deficient NuMA mutant is defective in microtubule bundling, and multiple spindles are induced during mitosis. The mitosis-dependent dynamic SUMO-1 modification of NuMA might contribute to NuMA-mediated formation and maintenance of mitotic spindle poles during mitosis.

  8. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Effect of leasing of an MA organization's... Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  9. Desgranadora para espigas individuales de maíz

    OpenAIRE

    Minchala Chumbi, Wilson Fabián; Quintuña Padilla, Sandro Xavier

    2001-01-01

    Las decisiones con las cuales los ingenieros mecánicos formulan planes para la realización física de máquinas, dispositivos y sistemas, son en base para satisfacer una demanda humana. De hecho, existe un número interminable de casos, y este es uno de ellos: el proceso de manufactura para desgranar maíz mediante sistemas mecánicos. Los problemas de diseño no tienen una sola respuesta. Seria absurdo exigir la “respuesta correcta” a un problema de diseño. En el presente proyecto de grado ...

  10. Protection, transfer, and maintenance of the MA23 bilateral servomanipulator

    International Nuclear Information System (INIS)

    Vertut, J.; Marchal, P.; Germond, J.C.; Francois, D.; Brossard, J.P.

    1978-01-01

    After a successful plasma torch cutting test, use of the MA23 in a large cell for maintenance in the new reprocessing plant is anticipated. A protective self-ventilated caisson with a boot is used. The arm is transferred into a decontamination-shielded box, then into a repair glove box. The caisson is repaired in a similar parallel line that has two connecting repair boxes. The recent two-operator glove-box recabling test showed the feasibility of this concept. Total labor was twice that of factory cabling labor. Arm improvement and tooling are being designed. A full, double-maintenance line mockup will be tested in mid-1979

  11. Advanced Query and Data Mining Capabilities for MaROS

    Science.gov (United States)

    Wang, Paul; Wallick, Michael N.; Allard, Daniel A.; Gladden, Roy E.; Hy, Franklin H.

    2013-01-01

    The Mars Relay Operational Service (MaROS) comprises a number of tools to coordinate, plan, and visualize various aspects of the Mars Relay network. These levels include a Web-based user interface, a back-end "ReSTlet" built in Java, and databases that store the data as it is received from the network. As part of MaROS, the innovators have developed and implemented a feature set that operates on several levels of the software architecture. This new feature is an advanced querying capability through either the Web-based user interface, or through a back-end REST interface to access all of the data gathered from the network. This software is not meant to replace the REST interface, but to augment and expand the range of available data. The current REST interface provides specific data that is used by the MaROS Web application to display and visualize the information; however, the returned information from the REST interface has typically been pre-processed to return only a subset of the entire information within the repository, particularly only the information that is of interest to the GUI (graphical user interface). The new, advanced query and data mining capabilities allow users to retrieve the raw data and/or to perform their own data processing. The query language used to access the repository is a restricted subset of the structured query language (SQL) that can be built safely from the Web user interface, or entered as freeform SQL by a user. The results are returned in a CSV (Comma Separated Values) format for easy exporting to third party tools and applications that can be used for data mining or user-defined visualization and interpretation. This is the first time that a service is capable of providing access to all cross-project relay data from a single Web resource. Because MaROS contains the data for a variety of missions from the Mars network, which span both NASA and ESA, the software also establishes an access control list (ACL) on each data record

  12. Study of the oxidation kinetics of the MA 956 superalloy

    International Nuclear Information System (INIS)

    Garcia-Alonso, M.C.; Gonzalez-Carrasco, J.L.; Escudero, M.L.

    1998-01-01

    This work deals with the oxidation kinetics of the MA 956 superalloy in the temperature range of 800-1,200 degree centigree for up to 200 h exposure. During oxidation the alloy develops a fine, compact and very well adhered α-alumina layer, the thickness of which increases with increasing time and temperature. The oxidation kinetics obeys a sub parabolic type behaviour. The scale growth seems to occur by two different oxidation mechanisms; above 1,050 degree centigree, the oxidation process would be controlled by α-alumina, and below 900 degree centigree by γ-alumina. (Author) 17 refs

  13. The one million volt X-ray therapy equipment at St Bartholomew's Hospital, 1936-1960

    International Nuclear Information System (INIS)

    Innes, G.S.

    1988-01-01

    St Bartholomew's Hospital in 1934 placed a contract with Messrs Metropolitan Vickers, of Manchester, for an X-ray therapy equipment to operate at 600 kV, 2mA d.c., but with the proviso that every effort would be made to attain an operating condition of 1000 kV, 4mA. The X-ray tube and rectifiers were to be continuously evacuated and demountable. This meant that components such as filaments, anodes and the target could be easily replaced, so providing cheap maintenance and continuous availability of the plant. No specification exists today, but one was assembled from the minutes of the Cancer Committee of the hospital and the contract pricing. A brief outline historical review is also presented, particularly of the personalities involved, and the War years 1939-1945. (author)

  14. Amsterdam - St. Paul Hotspot History

    OpenAIRE

    Janin, Myriam; Hémond, Christophe,; Maia, Marcia

    2010-01-01

    The Amsterdam St. Paul hotspot (Indian Ocean) interacts with a regional depleted mantle containing some DUPAL-like blobs. Its lateral motion velocity is about 1-2 cm/yr. The plume induced the construction of a volcanic chain and of an oceanic plateau through two pulses of more intense magmatic activity. The intraplate plate activity appears partially controlled by some tectonic stress induced by the diverging motion of the Australian and Capricorn plates along a diffuse boundary.

  15. Rae1 interaction with NuMA is required for bipolar spindle formation.

    Science.gov (United States)

    Wong, Richard W; Blobel, Günter; Coutavas, Elias

    2006-12-26

    In eukaryotic cells, the faithful segregation of daughter chromosomes during cell division depends on formation of a microtubule (MT)-based bipolar spindle apparatus. The Nuclear Mitotic Apparatus protein (NuMA) is recruited from interphase nuclei to spindle MTs during mitosis. The carboxy terminal domain of NuMA binds MTs, allowing a NuMA dimer to function as a "divalent" crosslinker that bundles MTs. The messenger RNA export factor, Rae1, also binds to MTs. Lowering Rae1 or increasing NuMA levels in cells results in spindle abnormalities. We have identified a mitotic-specific interaction between Rae1 and NuMA and have explored the relationship between Rae1 and NuMA in spindle formation. We have mapped a specific binding site for Rae1 on NuMA that would convert a NuMA dimer to a "tetravalent" crosslinker of MTs. In mitosis, reducing Rae1 or increasing NuMA concentration would be expected to alter the valency of NuMA toward MTs; the "density" of NuMA-MT crosslinks in these conditions would be diminished, even though a threshold number of crosslinks sufficient to stabilize aberrant multipolar spindles may form. Consistent with this interpretation, we found that coupling NuMA overexpression to Rae1 overexpression or coupling Rae1 depletion to NuMA depletion prevented the formation of aberrant spindles. Likewise, we found that overexpression of the specific Rae1-binding domain of NuMA in HeLa cells led to aberrant spindle formation. These data point to the Rae1-NuMA interaction as a critical element for normal spindle formation in mitosis.

  16. Milk Oligosaccharides Inhibit Human Rotavirus Infectivity in MA104 Cells.

    Science.gov (United States)

    Laucirica, Daniel R; Triantis, Vassilis; Schoemaker, Ruud; Estes, Mary K; Ramani, Sasirekha

    2017-09-01

    Background: Oligosaccharides in milk act as soluble decoy receptors and prevent pathogen adhesion to the infant gut. Milk oligosaccharides reduce infectivity of a porcine rotavirus strain; however, the effects on human rotaviruses are less well understood. Objective: In this study, we determined the effect of specific and abundant milk oligosaccharides on the infectivity of 2 globally dominant human rotavirus strains. Methods: Four milk oligosaccharides-2'-fucosyllactose (2'FL), 3'-sialyllactose (3'SL), 6'-sialyllactose (6'SL), and galacto-oligosaccharides-were tested for their effects on the infectivity of human rotaviruses G1P[8] and G2P[4] through fluorescent focus assays on African green monkey kidney epithelial cells (MA104 cells). Oligosaccharides were added at different time points in the infectivity assays. Infections in the absence of oligosaccharides served as controls. Results: When compared with infections in the absence of glycans, all oligosaccharides substantially reduced the infectivity of both human rotavirus strains in vitro; however, virus strain-specific differences in effects were observed. Compared with control infections, the maximum reduction in G1P[8] infectivity was seen with 2'FL when added after the onset of infection (62% reduction, P rotaviruses in MA104 cells, primarily through an effect on the virus. Although breastfed infants are directly protected, the addition of specific oligosaccharides to infant formula may confer these benefits to formula-fed infants. © 2017 American Society for Nutrition.

  17. 5 MV 30 mA industrial electron processing system

    Science.gov (United States)

    Hoshi, Y.; Mizusawa, K.

    1991-05-01

    Industrial electron beam processing systems have been in use in various application fields such as: improving heat resistivity of wire insulation; controlling quality of automobile rubber tires and melt index characteristics of PE foams; and curing paintings or printing inks. Recently, there has come up a need for electron beam with an energy higher than 3 MV in order to disinfect salmonella in chicken meat, to kill bugs in fruits, and to sterilize medical disposables. To meet this need we developed a 5 MV 30 mA electron processing system with an X-ray conversion target. The machine was tested in NHV's plant in Kyoto at continuous operation of full voltage and full current. It proved to be very steady in operation with a high efficiency (as much as 72%). Also, the X-ray target was tested in a continuous run of 5 MV 30 mA (150 kW). It proved to be viable in industrial utilization. This paper introduces the process and the results of the development.

  18. NuMA influences higher order chromatin organization in human mammary epithelium.

    Science.gov (United States)

    Abad, Patricia C; Lewis, Jason; Mian, I Saira; Knowles, David W; Sturgis, Jennifer; Badve, Sunil; Xie, Jun; Lelièvre, Sophie A

    2007-02-01

    The coiled-coil protein NuMA is an important contributor to mitotic spindle formation and stabilization. A potential role for NuMA in nuclear organization or gene regulation is suggested by the observations that its pattern of nuclear distribution depends upon cell phenotype and that it interacts and/or colocalizes with transcription factors. To date, the precise contribution of NuMA to nuclear function remains unclear. Previously, we observed that antibody-induced alteration of NuMA distribution in growth-arrested and differentiated mammary epithelial structures (acini) in three-dimensional culture triggers the loss of acinar differentiation. Here, we show that in mammary epithelial cells, NuMA is present in both the nuclear matrix and chromatin compartments. Expression of a portion of the C terminus of NuMA that shares sequence similarity with the chromatin regulator HPC2 is sufficient to inhibit acinar differentiation and results in the redistribution of NuMA, chromatin markers acetyl-H4 and H4K20m, and regions of deoxyribonuclease I-sensitive chromatin compared with control cells. Short-term alteration of NuMA distribution with anti-NuMA C-terminus antibodies in live acinar cells indicates that changes in NuMA and chromatin organization precede loss of acinar differentiation. These findings suggest that NuMA has a role in mammary epithelial differentiation by influencing the organization of chromatin.

  19. Preferential expression of NuMA in the nuclei of proliferating cells.

    Science.gov (United States)

    Taimen, P; Viljamaa, M; Kallajoki, M

    2000-04-10

    Nuclear mitotic apparatus protein (NuMA) has an indispensable function in normal mitosis as an organizer of the mitotic spindle. NuMA is a prominent component of interphase cell nuclear matrix but its role during interphase is largely unknown. We examined the presence of NuMA in several human tissues. The majority of cells were positive for NuMA but a few negative cell types were found, including spermatozoa, superficial keratinocytes, neutrophil granulocytes, syncytiotrophoblasts, and some neurons, fibroblasts, and smooth and skeletal muscle cells. We further investigated the presence of NuMA in a cultured estrogen-dependent human breast cancer cell line and observed the disappearance of nuclear NuMA in the quiescent cells. The percentage of NuMA-positive cells diminished from an initial approximately 100 to 60% during 6 days of culture. The presence of NuMA correlated positively with the presence of proliferation marker Ki-67 antigen and negatively with the culture time, confluence, and size of the cell islets. These results show that some nonproliferating, highly differentiated cell types lack NuMA and that cells may lose their NuMA without dramatic effects on the nuclear shape. This suggests that NuMA may be a nonessential component of the interphase nucleus. Copyright 2000 Academic Press.

  20. Mitochonic Acid 5 (MA-5 Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases

    Directory of Open Access Journals (Sweden)

    Tetsuro Matsuhashi

    2017-06-01

    Full Text Available Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders. Several antioxidant therapies and drugs affecting mitochondrial biogenesis are undergoing investigation, although not all of them have demonstrated favorable effects in the clinic. We recently reported a therapeutic mitochondrial drug mitochonic acid MA-5 (Tohoku J. Exp. Med., 2015. MA-5 increased ATP, rescued mitochondrial disease fibroblasts and prolonged the life span of the disease model “Mitomouse” (JASN, 2016. To investigate the potential of MA-5 on various mitochondrial diseases, we collected 25 cases of fibroblasts from various genetic mutations and cell protective effect of MA-5 and the ATP producing mechanism was examined. 24 out of the 25 patient fibroblasts (96% were responded to MA-5. Under oxidative stress condition, the GDF-15 was increased and this increase was significantly abrogated by MA-5. The serum GDF-15 elevated in Mitomouse was likewise reduced by MA-5. MA-5 facilitates mitochondrial ATP production and reduces ROS independent of ETC by facilitating ATP synthase oligomerization and supercomplex formation with mitofilin/Mic60. MA-5 reduced mitochondria fragmentation, restores crista shape and dynamics. MA-5 has potential as a drug for the treatment of various mitochondrial diseases. The diagnostic use of GDF-15 will be also useful in a forthcoming MA-5 clinical trial.

  1. Tren Pendidikan Teologi Di Dunia (Perspektif C&MA “Quality Control”: Keunggulan Dalam Pendidikan Teologi

    Directory of Open Access Journals (Sweden)

    Andrew Scott Brake

    2015-03-01

    area of administration. The speaks primarily to the area of honesty, integrity, and seeking to enter the technological world of the 21st century. Fourthly is excellence in the area of character, or spiritual formation. If a school attends to these four areas of excellence, the future will be promising.Keywords: Excellence, theological education, leadership, spiritual formation, example, orality, administration, C&MA perspective, higher education, publishing

  2. Mexican data indicating ca.700 Ma breakup of Rodinia and ca.550 Ma separation of Avalonia: analogous to events in western Laurentia

    Science.gov (United States)

    Keppie, J. D.; Nance, R. D.; Miller, B. V.; Dostal, J.

    2004-05-01

    The supercontinent, Rodinia, appears to have been amalgamated by ca.1 Ga, however, its breakup in Laurentia appears to have occurred in two stages. Current hypotheses suggest that East Gondwana or Siberia separated from western Laurentia at ca.700 Ma followed by separation of (?) South China at ca.550 Ma producing two superposed passive margin sequences. Although prevailing wisdom suggests that the birth of Iapetus between North and South America occurred at ca.550 Ma, a similar 2-stage process is evident in both eastern Laurentia and Mexico. At ca.1 Ga, Mexico appears to have been located in or close to the North-South America suture and so provides crucial data. Geochronological data indicate that cooling following ca.1 Ga granulite facies orogenesis in Mexico followed two different paths. In southern Mexico the rocks initially cooled through ca.450° C at a rate of ca.8° C/my between 978 Ma and 945 Ma related to flat-slab subduction, followed by a cooling rate of ca.2° C/my through ca.150° C. In northern Mexico the rocks cooled at a steady rate of ca.1.8° C/my through ca.300° C and are cut by plume-related mafic dykes. Extrapolating these cooling paths to the surface indicates that southern Mexico reached the surface between 710 and 760 Ma, whereas northern Mexico reached the surface by 550 Ma. This may be partly explained by different depths of exhumation: 30 versus 37 km for southern and northern Mexico, respectively. On the other hand, the oldest rocks resting on the ca.1 Ga basement are Tremadocian (ca.490-480 Ma) in southern Mexico and Middle Silurian (ca.430-425 Ma) in northern Mexico. Thus it would appear that Mexico records two breakup stages: (1) at ca.700 Ma possibly related to the breakup of Rodinia; (2) at ca.550 Ma possibly related to the transcurrent separation of Avalonia followed by thermal equilibration at ca.500 Ma leading to subsidence and development of a passive margin. These data suggest that the breakup of Rodinia occurred at ca.700

  3. Sesli Okuma ve Konuşma Prozodisi: İlişkisel Bir Çalışma

    Directory of Open Access Journals (Sweden)

    Hasan Keskin

    2013-02-01

    Full Text Available Bu araştırma,  ilköğretim dördüncü sınıf öğrencilerinin sesli okuma ve konuşma prozodileri arasındaki ilişkiyi incelemek amacıyla ilişkisel tarama modelinde yapılmıştır. Araştırmaya,  Konya ve Afyonkarahisar’da ilköğretim dördüncü sınıfa devam eden 50 öğrenci katılmıştır.  Öğrencilerin sesli okumaları ve konuşmaları video ile kayıt altına alınmış, daha sonra bu kayıtlar üzerinde ölçekler aracılığıyla puanlamalar yapılmıştır. Sesli okuma ve konuşma prozodisi arasındaki ilişkiyi belirlemeye yönelik, Pearson Momentler Çarpım Korelasyon Tekniği kullanılmıştır. Analiz sonuçlarına göre, öğrencilerin sesli okuma ve konuşma prozodileri arasında, pozitif yönlü orta düzeyde bir ilişki çıkmıştır. Öğrencilerin sesli okumaları ve konuşma prozodi puanları cinsiyet açısından ayrı ayrı incelenmiş; kız ve erkek öğrencilerin ortalamaları arasında anlamlı bir farklılık çıkmamıştır. Ayrıca, öğrencilerin sesli okuma ve konuşmalarındaki prozodik düzeyi belirlemeye yönelik ölçümler yapılmıştır. Bu ölçüm sonuçlarına göre, araştırmaya katılan öğrencilerin %52’sinin sesli okuma prozodilerinin,  %48’inin ise konuşma prozodilerinin düşük düzeyde olduğu görülmüştür.

  4. SCHeMA open and modular in situ sensing solution

    Science.gov (United States)

    Tercier-Waeber, Marie Louise; Novellino, Antonio

    2017-04-01

    Marine environments are highly vulnerable and influenced by a wide diversity of anthropogenic and natural substances and organisms that may have adverse effects on the ecosystem equilibrium, on living resources and, ultimately, on human health. Identification of relevant types of hazards at the appropriate temporal and spatial scale is crucial to detect their sources and origin, to understand the processes governing their magnitude and distribution, and to ultimately evaluate and manage their risks and consequences preventing economic losses. This can be addressed only by the development of innovative, compact, rugged, automated, sensor networks allowing long-term monitoring. Development of such tools is a challenging task as it requires many analytical and technical innovations. The FP7-OCEAN 2013-SCHeMA project aims to contribute to meet this challenge by providing an open and modular sensing solution for autonomous in situ high resolution mapping of a range of anthropogenic and natural chemical compounds (trace metals, nutrients, anthropogenic organic compounds, toxic algae species and toxins, species relevant to the carbon cycle). To achieve this, SCHeMA activities focus on the development of : 1) an array of miniature sensor probes taking advantage of various innovative solutions, namely: (polymer-based) gel-integrated sensors; solid state ion-selective membrane sensors coupled to an on-line desalination module; mid-infrared optical sensors; optochemical multichannel devices; enOcean technology; 2) dedicated hardware, firmware and software components allowing their plug-and-play integration, localization as well as wireless bidirectional communication via advanced OGC-SWE wired/wireless dedicated interfaces; 3) a web-based front-end system compatible with EU standard requirements and principles (INSPIRE, GEO/GEOSS) and configured to insure easy interoperability with national, regional and local marine observation systems. This lecture will present examples of

  5. Observation of Kuznetsov-Ma soliton dynamics in optical fibre

    Science.gov (United States)

    Kibler, B.; Fatome, J.; Finot, C.; Millot, G.; Genty, G.; Wetzel, B.; Akhmediev, N.; Dias, F.; Dudley, J. M.

    2012-01-01

    The nonlinear Schrödinger equation (NLSE) is a central model of nonlinear science, applying to hydrodynamics, plasma physics, molecular biology and optics. The NLSE admits only few elementary analytic solutions, but one in particular describing a localized soliton on a finite background is of intense current interest in the context of understanding the physics of extreme waves. However, although the first solution of this type was the Kuznetzov-Ma (KM) soliton derived in 1977, there have in fact been no quantitative experiments confirming its validity. We report here novel experiments in optical fibre that confirm the KM soliton theory, completing an important series of experiments that have now observed a complete family of soliton on background solutions to the NLSE. Our results also show that KM dynamics appear more universally than for the specific conditions originally considered, and can be interpreted as an analytic description of Fermi-Pasta-Ulam recurrence in NLSE propagation. PMID:22712052

  6. Status of the PuMa-ECR (Pulsed Magnetic field)

    International Nuclear Information System (INIS)

    Ratzinger, U.; Muehle, C.; Bleuel, W.; Joest, G.; Leible, K.; Schennach, S.; Wolf, B.H.

    1993-01-01

    Synchrotrons like the heavy ion synchrotron SIS at GSI need an efficient low duty cycle injector (typical 1 pulse/s and 200 μs pulse length). To improve the peak current, an ECR ion source has been designed using a pulsed magnetic field to force ion extraction. We replaced the hexapole of a 10 GHz MINIMAFIOS ECR ion source by a vacuum chamber containing a watercooled bilayered solenoid coil and a decapole permanent magnetic structure. A pulse line feeds the solenoid with a 250 μs pulse which increases the magnetic field in the minimum B region by 0.3 Tesla. This process opens the magnetic bottle along the beam axis resulting in an extracted ion pulse. First tests of the PuMa-ECR configuration in cw and pulsed operation are presented and analysed. (orig.)

  7. Random fields, topology, and the Imry-Ma argument.

    Science.gov (United States)

    Proctor, Thomas C; Garanin, Dmitry A; Chudnovsky, Eugene M

    2014-03-07

    We consider an n-component fixed-length order parameter interacting with a weak random field in d=1, 2, 3 dimensions. Relaxation from the initially ordered state and spin-spin correlation functions are studied on lattices containing hundreds of millions of sites. At n ≤ d the presence of topological defects leads to strong metastability and glassy behavior, with the final state depending on the initial condition. At n=d+1, when topological structures are nonsingular, the system possesses a weak metastability. At n>d+1, when topological objects are absent, the final, lowest-energy state is independent of the initial condition. It is characterized by the exponential decay of correlations that agrees quantitatively with the theory based upon the Imry-Ma argument.

  8. Interfacing transformer for a pulsed load current exceeding 1 MA

    CERN Document Server

    Cliffe, R J; Brown, J

    2003-01-01

    In much pulsed power experimentation a capacitor bank is discharged into an inductive load, but although sufficient energy may be available in the capacitors their voltage rating may considerably exceed that necessary for the load and the current delivered during the experiment may accordingly be too low. This paper describes a novel design of air-cored transformer that has been used as an interfacing or matching device in such a situation, where peak load currents between 1 and 2 MA were required. Design considerations led to the use of an air-cored autotransformer connection wound with copper sheet conductors. Although thick wide conductors and clamping are needed to prevent deformation due to high magnetic pressure, the transformer is nevertheless relatively simple, easy to make, lightweight and inexpensive. This paper describes the design and the winding arrangement of the transformer that was constructed, and presents typical experimental results.

  9. Měření střední radiační teploty

    OpenAIRE

    Truksa, Lukáš

    2012-01-01

    Závěrečná práce je zaměřena na parametry prostředí, především na střední radiační teplotu, která představuje parametr s dobrou vypovídající schopností. V bakalářské práci se seznámíme se způsoby měření střední radiační teploty a s vhodnými přístroji určených pro toto měření. Nedílnou součástí práce je také seznámení s faktory tepelné pohody člověka, které ji výrazně ovlivňují. V další části bakalářské práce je návržen jednoduchý snímač pro měření střední radiační teploty a jeho ověření. Th...

  10. Comparative study of the wear resistance of Al2O3-coated MA956 superalloy

    International Nuclear Information System (INIS)

    Canahua Loza, H.; Escudero rincon, M. L.; Ruiz Fernandez, J.

    2000-01-01

    Preoxidation of the MA956 superalloy, proposed as prosthetic biomaterial, generates a compact and inert α-alumina surface layer. The aim of this study is to assess the wear resistance provided by this alumina layer on the MA956 alloy in comparison with the same coated alloy and versus high density polyethylene. Comparative wear tests were carried out in both dry and wet conditions using the couples MA956/MA956, MA956/UHMWPE (ultra high molecular weight polyethylene) and 316LVM/UHMWPE. The results corresponding to the couples MA956/MA956, with and without alumina layer, show that the load has more significant effect than the rotation speed on the weight loss and on the roughness. On the other hand the alumina surface layer provides a clear wear protection. The weight losses of the MA956 specimen in this couple are ten times lower when testing under wet conditions than under dry conditions. The MA956/UHMWPE couple behaves much better than the 316LVM/UHMWPE, as it presents the lowest values of friction coefficient and weight losses of the MA956 specimen. These are only detectable after 70,000 cycles under a 70 MPa contact pressure. This couple offers the best guarantee of a prolonged service life for articulated parts in a prosthesis. (Author) 18 refs

  11. NuMA: a nuclear protein involved in mitotic centrosome function.

    Science.gov (United States)

    Zeng, C

    2000-06-01

    Nuclear mitotic apparatus protein, NuMA, is an abundant 240 kDa protein with microtubule (MT) binding capacity via its carboxyl terminal region. Structurally, it has been shown to be a double-strand coiled-coil that has a high potential to form filamentous polymers. During interphase, NuMA locates within the nucleus but rapidly redistributes to the separating centrosomes during early mitosis. Xenopus NuMA associates with MT minus end-directed motor cytoplasmic dynein and its motility-activating complex dynactin at mitotic centrosomal regions. This NuMA-motor complex binds the free ends of MTs, converging and tethering spindle MT ends to the poles. A similar scenario appears to be true in higher vertebrates as well. As a mitotic centrosomal component, NuMA is essential for the organization and stabilization of spindle poles from early mitosis until at least the onset of anaphase. The cell cycle-dependent distribution and function of NuMA is regulated by phosphorylation and dephosphorylation, and p34/CDC2 activity is important to the mitotic role of NuMA. This review summarizes data about the structural features and mitotic function of NuMA with particular emphasis on the newly discovered NuMA-motor complex in spindle organization. Furthermore, NuMA may represent a large group of proteins whose mitotic function is sequestered in the nucleus during interphase. Copyright 2000 Wiley-Liss, Inc.

  12. The C terminus of the nuclear protein NuMA: phylogenetic distribution and structure.

    Science.gov (United States)

    Abad, Patricia C; Mian, I Saira; Plachot, Cedric; Nelpurackal, Aniysha; Bator-Kelly, Carol; Lelièvre, Sophie A

    2004-10-01

    The C terminus of the nuclear protein NuMA, NuMA-CT, has a well-known function in mitosis via its proximal segment, but it seems also involved in the control of differentiation. To further investigate the structure and function of NuMA, we exploited established computational techniques and tools to collate and characterize proteins with regions similar to the distal portion of NuMA-CT (NuMA-CTDP). The phylogenetic distribution of NuMA-CTDP was examined by PSI-BLAST- and TBLASTN-based analysis of genome and protein sequence databases. Proteins and open reading frames with a NuMA-CTDP-like region were found in a diverse set of vertebrate species including mammals, birds, amphibia, and early teleost fish. The potential structure of NuMA-CTDP was investigated by searching a database of protein sequences of known three-dimensional structure with a hidden Markov model (HMM) estimated using representative (human, frog, chicken, and pufferfish) sequences. The two highest scoring sequences that aligned to the HMM were the extracellular domains of beta3-integrin and Her2, suggesting that NuMA-CTDP may have a primarily beta fold structure. These data indicate that NuMA-CTDP may represent an important functional sequence conserved in vertebrates, where it may act as a receptor to coordinate cellular events.

  13. Interaction between RB protein and NuMA is required for proper alignment of spindle microtubules.

    Science.gov (United States)

    Uchida, Chiharu; Hattori, Takayuki; Takahashi, Hirotaka; Yamamoto, Naoki; Kitagawa, Masatoshi; Taya, Yoichi

    2014-02-01

    Retinoblastoma protein (pRB) controls cell cycle progression and cell cycle exit through interactions with cellular proteins. Many pRB-binding proteins, which function in gene transcription or modulation of chromatin structure, harbor LXCXE motifs in their binding domain for pRB. In this study, we found that nuclear mitotic apparatus protein (NuMA), a mitotic spindle organizer, interacts with pRB through LSCEE sequences located in its C-terminal region. siRNA-mediated down-regulation of pRB caused aberrant distribution of NuMA and alignment of spindle microtubules in mitotic cells. Abnormal organization of spindle microtubules was also accompanied by misalignment of an over-expressed NuMA mutant (mut-NuMA) with a defect in pRB binding caused by an LSGEK mutation. The mut-NuMA-over-expressing cells showed lower potency for survival than wild-type NuMA (wt-NuMA)-over-expressing cells during 2 weeks of culture. Interestingly, knockdown of pRB reduced the population of wt-NuMA-over-expressing cells to the same level as mut-NuMA cells after 2 weeks. Taken together, pRB may have a novel function in regulating the mitotic function of NuMA and spindle organization, which are required for proper cell cycle progression. © 2013 The Authors Genes to Cells © 2013 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd.

  14. MA-burners efficiency parameters allowing for the duration of transmutation process

    Energy Technology Data Exchange (ETDEWEB)

    Gulevich, A.; Zemskov, E. [Institute of Physics and Power Engineering, Bondarenko Square 1, Obninsk, Kaluga Region 249020 (Russian Federation); Kalugin, A.; Ponomarev, L. [Russian Research Center ' ' Kurchatov Institute' ' Kurchatov Square 1, Moscow 123182 (Russian Federation); Seliverstov, V. [Institute of Theoretical and Experimental Physics ul.B. Cheremushkinskaya 25, Moscow 117259 (Russian Federation); Seregin, M. [Russian Research Institute of Chemical Technology Kashirskoe Shosse 33, Moscow 115230 (Russian Federation)

    2010-07-01

    Transmutation of minor actinides (MA) means their transforming into the fission products. Usually, MA-burner's transmutation efficiency is characterized by the static parameters only, such as the number of neutrons absorbed and the rate of MA feeding. However, the proper characterization of MA-burner's efficiency additionally requires the consideration of parameters allowing for the duration of the MA transmutation process. Two parameters of that kind are proposed: a) transmutation time {tau} - mean time period from the moment a mass of MA is loaded into the burner's fuel cycle to be transmuted to the moment this mass is completely transmuted; b) number of reprocessing cycles n{sub rep} - effective number of reprocessing cycles a mass of loaded MA has to undergo before being completely transmuted. Some of MA-burners' types have been analyzed from the point of view of these parameters. It turned out that all of them have the value of parameters too high from the practical point of view. It appears that some new approaches to MA-burner's design have to be used to significantly reduce the value of these parameters in order to make the large-scale MA transmutation process practically reasonable. Some of such approaches are proposed and their potential efficiency is discussed. (authors)

  15. Special report: Mt. St. Helens

    Science.gov (United States)

    Mt. St Helens Volcano, Cascade Range, Southern Washington, USA (46.20°N, 122.18°W.) All times are local (GMT - 7 h through October 24, GMT - 8 h thereafter. Lava extrusion that probably began October 30 added a new lobe to the composite dome in the crater of Mt. St. Helens. After lava extrusion ended September 10 (see September 22 Eos), rates of deformation in the crater remained low for several weeks, as they had after earlier extrusion episodes. Sulfur dioxide emission ranged from 70 to 190 tons per day between October 9 and 24, but showed no particular trends. Inflation of the dome has caused small thrust faults to form in the surrounding crater floor. In early October the most active thrust, south of the dome, was moving at about 1.5 cm/d, and stations on the north crater rampart showed outward movement of about 0.5 cm/d. By October 24 these rates had increased to 14.5 and 3.5-4 cm/d, respectively, and leveling profiles perpendicular to the dome showed that crater floor tilt rates had reached 400-500 μrad/d, prompting the U.S. Geological Survey (USGS) to issue an advisory prediction of renewed lava extrusion within the next two weeks.

  16. Role of NuMA in vertebrate cells: review of an intriguing multifunctional protein.

    Science.gov (United States)

    Sun, Qing-Yuan; Schatten, Heide

    2006-01-01

    The 236 kDa large coiled-coil protein NuMA plays diverse important roles in vertebrate cells. It is an important component of the nuclear matrix in interphase cells, and is possibly involved in nuclear re-assembly after mitosis. In dividing cells, upon phosphorylation, NuMA disperses into the cytoplasm, associates with cytoplasmic dynein/dynactin to form a complex, and translocates along microtubules to the spindle poles where it organizes and tethers microtubules to spindle poles. It is thought that the stable complex of NuMA/dynein/dynactin is needed to focus microtubule minus ends to the spindle poles. But, it has also been reported that NuMA can organize microtubules in the absence of centrosomes and dynein. Another hypothesis suggests that once localized to the spindle poles, spindle-associated NuMA's exchange with cytoplasmic soluble pools and its stable crosslinking with the microtubule fibers are independent of dynein/dyactin. NuMA's function in spindle microtubule organization is regulated by RanGTP and Pins-related protein LGN. NuMA becomes dephosphorylated, loses its association with dynein/dynactin, and releases from spindle poles after anaphase onset to allow spindle disassembly and reformation of interphase daughter nuclei. The cell-cycle-dependent phosphorylation of NuMA is regulated by the balanced activities of protein kinases and phosphatases. It has been shown that phosphorylation of NuMA by cyclin B/cdc2 kinase allows NuMA to release from the nucleus and to associate with centrosomes and/or microtubules at the spindle poles, while NuMA's dephosphorylation due to the cyclin B degradation allows NuMA to dissociate from the spindle poles after anaphase onset. Overexpression of NuMA interferes with spindle-associated dynein localization and promotes multipolar spindle formation and cancer. On the other hand, NuMA is absent in many kinds of non-proliferating cells and highly differentiated cells. NuMA also functions during meiotic spindle

  17. Ma ma (2015: un reflejo de la mujer española con cáncer de mama

    Directory of Open Access Journals (Sweden)

    Clara Peralta?Nueno et al.

    2017-03-01

    Full Text Available Ma ma (2015 es una película de drama española dirigida por Julio Medem y producida por Morena Films. Esta película narra la historia de la vida de Magda cuyo personaje es interpretado por Penélope Cruz. Tras serle diagnosticado un cáncer de mama, Magda, una maestra en paro, no sabrá cómo actuar ni de qué manera cambiará esta enfermedad su vida, pero poco a poco sacará a la superficie toda su energía vital. El cáncer de mama representa el tipo de cáncer más frecuente en la mujer. Aunque la mayoría de los factores de riesgo identificados pueden ser modificables, los sistemas de salud se concentran en actividades que permiten fortalecer la prevención primaria y actividades de prevención secundaria y terciaria. La detección temprana y el tratamiento adecuado son indispensables para luchar contra esta enfermedad. El proceso emocional generado por la presencia de cáncer, conlleva un mecanismo de reconstitución psíquico que permite a la paciente conformar una respuesta a los desafíos orgánicos, cognitivos, sociales y emocionales a los cuales se ve enfrentada. Dicho proceso es favorecido entre otros factores por contar con una red de apoyo socio?familiar sólida.

  18. PROJECT AND ACTON STAGE OD DESIGNING FUTURE MUSIC TEACHERS’ ETHNOCULTURAL TRAINING

    Directory of Open Access Journals (Sweden)

    Xu Jiayu

    2017-04-01

    Full Text Available In the article the issue of developing future music teachers’ ethnocultural training in the process of their professional training is revealed. The author emphasizes on the relevance of the issue as future music teachers’ ethnocultural training contributes to, on the one hand, completing mastering the national system of cultural values of native people by students of higher musical educational institutions and, on the other hand, involving perception and understanding of other nations’ cultural values, allowing future music teachers to transmit values expressed by the young generation to their professional activity. It is reported that the main feature of future music teachers’ ethnocultural training is a system of ethnic and cultural values which is the background of musical and psychological-pedagogical and art training; it is actively engaged as value tools musical folk art and national art. Value methods that are involved in the process of training are methods of traditional pedagogy, as well as the basis of pedagogical communication – people’s ethics. It is noted that developing future music teachers’ ethnocultural training requires designing the special methodology. The constant items of this methodology are thought to be the forms, methods, techniques and means of pedagogical and ethnopedagogical impacts as tools for developing students’ ethnopedagogical thinking in the process of musical and pedagogical activities; the system of controlling future music teachers’ ethnopedagogical, ethnological, ethnomusical knowledge and skills as a combination of methods that enables an opportunity to compare the level of mastering the knowledge and skills at different stages of educational process; to organize tuition using innovative technologies. The special attention is paid to professional and active component of this methodology. The diagnostic tests according to the criterion of “a degree of professional effectiveness in solving ethnocultural problems of professional training” prove that ethnoculture can be simultaneously designed to the upbringing process of professional training.

  19. "Vernonia v. Acton": Should Schools Conduct Random Drug Tests of Student Athletes?

    Science.gov (United States)

    Mahon, J. Patrick

    1995-01-01

    In June 1995, the U.S. Supreme Court upheld the Vernonia (Oregon) School District's right to conduct random drug tests of its student athletes. The court balanced a seventh grader's privacy interest with the state's interest in curbing drug abuse among student athletes. Before adopting drug-testing policies, school boards should assess the local…

  20. A CH domain-containing N terminus in NuMA?

    Science.gov (United States)

    Novatchkova, Maria; Eisenhaber, Frank

    2002-10-01

    Nuclear mitotic apparatus protein (NuMA) is an essential vertebrate component in organizing microtubule ends at spindle poles. The NuMA-dynactin/dynein motor multiprotein complex not only explains the transport of NuMA along spindle fibers but also is linked to the process of microtubule focusing. The interaction sites of NuMA to dynein/dynactin have not been mapped. In the yet functionally uncharacterized N terminus of NuMA, we predict a calponin-homology (CH) domain, a motif with binding activity for actin-like molecules. We substantiate the primary sequence analysis-based prediction with secondary structure and fold recognition analysis, and we propose the N-terminal CH domain of NuMA as a likely interaction site for actin-related protein 1 (Arp1) protein of the dynactin/dynein complex.

  1. Formation of spindle poles by dynein/dynactin-dependent transport of NuMA.

    Science.gov (United States)

    Merdes, A; Heald, R; Samejima, K; Earnshaw, W C; Cleveland, D W

    2000-05-15

    NuMA is a large nuclear protein whose relocation to the spindle poles is required for bipolar mitotic spindle assembly. We show here that this process depends on directed NuMA transport toward microtubule minus ends powered by cytoplasmic dynein and its activator dynactin. Upon nuclear envelope breakdown, large cytoplasmic aggregates of green fluorescent protein (GFP)-tagged NuMA stream poleward along spindle fibers in association with the actin-related protein 1 (Arp1) protein of the dynactin complex and cytoplasmic dynein. Immunoprecipitations and gel filtration demonstrate the assembly of a reversible, mitosis-specific complex of NuMA with dynein and dynactin. NuMA transport is required for spindle pole assembly and maintenance, since disruption of the dynactin complex (by increasing the amount of the dynamitin subunit) or dynein function (with an antibody) strongly inhibits NuMA translocation and accumulation and disrupts spindle pole assembly.

  2. NuMA is required for proper spindle assembly and chromosome alignment in prometaphase.

    Science.gov (United States)

    Haren, Laurence; Gnadt, Nicole; Wright, Michel; Merdes, Andreas

    2009-04-28

    NuMA is a protein that has been previously shown to play a role in focusing microtubules at the mitotic spindle poles. However, most previous work relies on experimental methods that might cause dominant side effects on spindle formation, such as microinjection of antibodies, overexpression of mutant protein, or immunodepletion of NuMA-containing protein complexes. To circumvent these technical problems, we performed siRNA experiments in which we depleted the majority of NuMA in human cultured cells. Depleted mitotic cells show a prolonged duration of prometaphase, with spindle pole defects and with unattached, unaligned chromosomes. Our data confirm that NuMA is important for spindle pole formation, and for cohesion of centrosome-derived microtubules with the bulk of spindle microtubules. Our findings of NuMA-dependent defects in chromosome alignment suggest that NuMA is involved in stabilizing kinetochore fibres.

  3. Some fossil Clypeastrids (Echinoidea) from Brimstone Hill (St. Kitts) and Sugar Loaf (St. Eustatius), Lesser Antilles

    NARCIS (Netherlands)

    Engel, H.

    1961-01-01

    In March 1958 Dr. J. H. WESTERMANN and Mr. H. KIEL collected some fossil Echinids on the islands of St. Kitts and St. Eustatius. The fossils of St. Kitts were found in a yellow limestone (sample nr. 42), situated on the west flank of Brimstone Hill, belonging to a series of peculiar-looking upturned

  4. NuMA and nuclear lamins behave differently in Fas-mediated apoptosis.

    Science.gov (United States)

    Taimen, Pekka; Kallajoki, Markku

    2003-02-01

    NuMA is a nuclear matrix protein that has an essential function in the organization of the mitotic spindle. Here we have studied the fate of NuMA in Fas-treated apoptotic Jurkat T and HeLa cells. We show that in both cell lines NuMA is an early target protein for caspases and that NuMA is cleaved coincidently with poly(ADP-ribose) polymerase-1 (PARP-1) and nuclear lamin B. NuMA is cleaved differently in Jurkat T and HeLa cells, suggesting that different sets of caspases are activated in these cell lines. The normal diffuse intranuclear distribution of NuMA changed during apoptosis: first NuMA condensed, then concentrated in the center of the nucleus and finally encircled the nuclear fragments within the apoptotic bodies. NuMA seems to be preferentially cleaved by caspase-3 in vivo since it was not cleaved in staurosporine-treated caspase-3-null MCF-7 breast cancer cells. The cleavage of NuMA, lamin B and PARP-1 was inhibited in the presence of three different caspase inhibitors: z-DEVD-FMK, z-VEID-FMK and z-IETD-FMK. Furthermore, in the presence of caspase inhibitors approximately 5-10% of the cells showed atypical apoptotic morphology. These cells had convoluted nuclei, altered chromatin structure and additionally, they were negative for NuMA and lamins. Since caspase-8, -3 and -7 were not activated and PARP was not cleaved in these cells as judged by western blotting and immunofluorescence studies, it is likely that this is an atypical form of programmed cell death owing to a proteinase(s) independent of caspases. These results characterize the role of NuMA in programmed cell death and suggest that cleavage of NuMA plays a role in apoptotic nuclear breakdown.

  5. 21st Century Security Manager

    Directory of Open Access Journals (Sweden)

    Stelian ARION

    2010-11-01

    Full Text Available We live in world of uncertainty that generates major paradigms changing that affect security risk management. Modern organization’s security risks management can’t be done without a profound knowlegde and daily practice for security governance, security risk management and resilience. 21st Century security manager need to deal with several areas of konwledge in order to succesfully manage security risks. The document presents the advantages, disadvantages and challenges for security managers thah have government backgroud, or IT security backgroud, or are promoted from organization’s inside leaders. There are six different areas of knowledge that successful security programs of the future must incorporate, either in the knowledge base of their leaders or in the collective knowledge of the leading staff. They are government elements, security organization, emerging issue awareness, IT security, business elements and executive leadership.

  6. Countering 21st Century Threats

    DEFF Research Database (Denmark)

    Scharling Pedersen, Peter; Pillai, Chad M.; Hun, Lee Jae

    2015-01-01

    The United States and its Allies confront an increasingly volatile world where threats range from traditional state-on-state challenges to non-state transnational networks. To successfully combat these 21st Century problems, in an era of resource and geo-political power constraints, the U...... to be addressed in order to successfully conduct IW. As result of researching the issues associated with developing a JIIM approach to IW, the paper makes the following recommendations: • Establishing universally accepted concepts and doctrines for IW, UW, Foreign Internal Defense (FID), Counter Insurgency (COIN......), Counter-Terrorism (CT), and Security and Stability Operations (SSO). • Establishing a construct that allows a strategic Whole-of-Government capacity for operations coordinated by joint interagency task forces. • Continue to developing the Global SOF network. • Increased intelligence sharing in areas...

  7. 21st International Meshing Roundtable

    CERN Document Server

    Weill, Jean-Christophe

    2013-01-01

    This volume contains the articles presented at the 21st International Meshing Roundtable (IMR) organized, in part, by Sandia National Laboratories and was held on October 7–10, 2012 in San Jose, CA, USA. The first IMR was held in 1992, and the conference series has been held annually since. Each year the IMR brings together researchers, developers, and application experts in a variety of disciplines, from all over the world, to present and discuss ideas on mesh generation and related topics. The technical papers in this volume present theoretical and novel ideas and algorithms with practical potential, as well as technical applications in science and engineering, geometric modeling, computer graphics, and visualization.

  8. Development of a Hydronic Rooftop Unit-HyPak-MA

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eric; Berman, Mark

    2009-11-14

    The majority of U.S. commercial floor space is cooled by rooftop HVAC units (RTUs). RTU popularity derives chiefly from their low initial cost and relative ease of service access without disturbing building occupants. Unfortunately, current RTUs are inherently inefficient due to a combination of characteristics that unnecessarily increase cooling loads and energy use. 36% percent of annual U.S. energy, and two-thirds of electricity, is consumed in and by buildings. Commercial buildings consume approximately 4.2 quads of energy each year at a cost of $230 billion per year, with HVAC equipment consuming 1.2 quads of electricity. More than half of all U.S. commercial floor space is cooled by packaged HVAC units, most of which are rooftop units (RTUs). Inefficient RTUs create an estimated 3.5% of U.S. CO{sub 2} emissions, thus contributing significantly to global warming5. Also, RTUs often fail to maintain adequate ventilation air and air filtration, reducing indoor air quality. This is the second HyPak project to be supported by DOE through NETL. The prior project, referred to as HyPak-1 in this report, had two rounds of prototype fabrication and testing as well as computer modeling and market research. The HyPak-1 prototypes demonstrated the high performance capabilities of the HyPak concept, but made it clear that further development was required to reduce heat exchanger cost and improve system reliability before HyPak commercialization can commence. The HyPak-1 prototypes were limited to about 25% ventilation air fraction, limiting performance and marketability. The current project is intended to develop a 'mixed-air' product that is capable of full 0-100% modulation in ventilation air fraction, hence it was referred to as HyPak-MA in the proposal. (For simplicity, the -MA has been dropped when referencing the current project.) The objective of the HyPak Project is to design, develop and test a hydronic RTU that provides a quantum improvement over

  9. Integrated EPA Science for Decision-Making: Lawrence, MA Water Strategy

    Science.gov (United States)

    Powerpoint presentation on the Lawrence MA Making a Visible Difference in Communities project’s comprehensive water quality strategy, demonstrating a systems approach applying integrated EPA science

  10. Development of a dispersion strengthened copper alloy using a MA-HIP method

    Directory of Open Access Journals (Sweden)

    T. Yamada

    2016-12-01

    Full Text Available A new Cu-Al alloy was fabricated by a MA-HIP method for application to the heat sink materials of divertors. With the increase in MA time, the grain size and Vickers hardness decreased and increased, respectively. At MA time of 32hrs, the hardness of the alloy was comparable to that of Glidcop® although the grain size was much larger. X-ray diffractometry, electrical resistivity measurements and STEM-EDS analyses suggested precipitation of Al-rich phase by MA for 32hrs followed by HIP.

  11. Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation.

    Science.gov (United States)

    Zheng, Zhen; Wan, Qingwen; Meixiong, Gerry; Du, Quansheng

    2014-03-01

    Accurate and efficient separation of sister chromatids during anaphase is critical for faithful cell division. It has been proposed that cortical dynein-generated pulling forces on astral microtubules contribute to anaphase spindle elongation and chromosome separation. In mammalian cells, however, definitive evidence for the involvement of cortical dynein in chromosome separation is missing. It is believed that dynein is recruited and anchored at the cell cortex during mitosis by the α subunit of heterotrimeric G protein (Gα)/mammalian homologue of Drosophila Partner of Inscuteable/nuclear mitotic apparatus (NuMA) ternary complex. Here we uncover a Gα/LGN-independent lipid- and membrane-binding domain at the C-terminus of NuMA. We show that the membrane binding of NuMA is cell cycle regulated-it is inhibited during prophase and metaphase by cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation and only occurs after anaphase onset when CDK1 activity is down-regulated. Further studies indicate that cell cycle-regulated membrane association of NuMA underlies anaphase-specific enhancement of cortical NuMA and dynein. By replacing endogenous NuMA with membrane-binding-deficient NuMA, we can specifically reduce the cortical accumulation of NuMA and dynein during anaphase and demonstrate that cortical NuMA and dynein contribute to efficient chromosome separation in mammalian cells.

  12. Correlation among nuclear localization of NuMA-RARα, deregulation of gene expression and leukemic phenotype of hCG-NuMA-RARα transgenic mice.

    Science.gov (United States)

    Sukhai, Mahadeo A; Thomas, Mariam; Hamadanizadeh, Soheila A; Xuan, Yali; Wells, Richard A; Kamel-Reid, Suzanne

    2011-05-01

    Acute promyelocytic leukemia (APL) is a model system of aberrant transcription in cancer. We sought to elucidate the mechanism of action of the variant fusion NuMA-RARα in APL, using the hCG-NuMA-RARα transgenic model. We report that subcellular localization of NuMA-RARα in transgenic mice is dependent upon its protein expression and transgene dosage. Subcellular localization of the fusion is inversely correlated with extent of gene deregulation at the mRNA level for Cebpα, Cebpɛ and Pu.1. Finally, we report that phenotype onset is correlated with NuMA-RARα copy number; mice with higher copy number developing disease later than those with lower copy number. Copyright © 2010 Elsevier Ltd. All rights reserved.

  13. Firmaets Største Bedrift

    DEFF Research Database (Denmark)

    Hansen, Peer Henrik

    fortæller, hvordan de tidligere modstandsfolk Arne Sejr og Niels Frommelt få år efter befrielsen etablerede deres såkaldte Firma for med støtte fra ledende danske politikere, Forsvarets Efterretningstjeneste og CIA at organisere en hemmelig krig mod Sovjetunionens danske støtter. Meget tyder på, at både...

  14. Na téma svatováclavského jubilea

    Czech Academy of Sciences Publication Activity Database

    Benešovská, Klára

    2008-01-01

    Roč. 20, č. 2 (2008), s. 26-28 ISSN 0862-612X Institutional research plan: CEZ:AV0Z80330511 Keywords : St Wenceslas * St Wenceslas jubilee * cult of St Wenceslas Subject RIV: AL - Art, Architecture, Cult ural Heritage http://www.dejinyumeni.cz/bulletin/UHS_2_2008.pdf

  15. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2005-02-25

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. Rev. 0 marks the first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database.

  16. SDSS IV MaNGA - Properties of AGN Host Galaxies

    Science.gov (United States)

    Sánchez, S. F.; Avila-Reese, V.; Hernandez-Toledo, H.; Cortes-Suárez, E.; Rodríguez-Puebla, A.; Ibarra-Medel, H.; Cano-Díaz, M.; Barrera-Ballesteros, J. K.; Negrete, C. A.; Calette, A. R.; de Lorenzo-Cáceres, A.; Ortega-Minakata, R. A.; Aquino, E.; Valenzuela, O.; Clemente, J. C.; Storchi-Bergmann, T.; Riffel, R.; Schimoia, J.; Riffel, R. A.; Rembold, S. B.; Brownstein, J. R.; Pan, K.; Yates, R.; Mallmann, N.; Bitsakis, T.

    2018-04-01

    We present the characterization of the main properties of a sample of 98 AGN host galaxies, both type-II and type-I, in comparison with those of ≍2700 non-active galaxies observed by the MaNGA survey. We found that AGN hosts are morphologically early-type or early-spirals. AGN hosts are, on average, more massive, more compact, more centrally peaked and more pressure-supported systems. They are located in the intermediate/transition region between starforming and non-star-forming galaxies (i.e., the so-called green valley). We consider that they are in the process of halting/quenching the star formation. The analysis of the radial distributions of different properties shows that the quenching happens from inside-out involving both a decrease of the effciency of the star formation and a deficit of molecular gas. The data-products of the current analysis are distributed as a Value Added Catalog within the SDSS-DR14.

  17. MaMBA - a functional Moon and Mars Base Analog

    Science.gov (United States)

    Heinicke, C.; Foing, B.

    2017-09-01

    Despite impressive progress in robotic exploration of celestial bodies, robots are believed to never reach the effectiveness and efficiency of a trained human. Consequently, ESA proposes to build an international Moon Village in roughly 15 years and NASA plans for the first manned mission to Mars shortly after. One of the challenges still remaining is the need for a shelter, a habitat which allows human spacefarers to safely live and work on the surface of a celestial body. Although a number of prototype habitats has been built during the last decades and inhabited for various durations (e.g. MDRS, FMARS, HI-SEAS, M.A.R.S.), these habitats are typically equipped for studies on human factors and would not function in an extraterrestrial environment. Project MaMBA (Moon and Mars Base Analog) aims to build the first functional habitat based on the lessons learned from intermediate and long duration missions at the mentioned habitats. The habitat will serve for testing technologies like life support, power systems, and interplanetary communi­cation. Special attention will be given to the develop­ment of the geoscience laboratory module. Crews will live and work inside the habitat to ensure its functionality.

  18. Voix over et peur au cinéma

    Directory of Open Access Journals (Sweden)

    Martin Barnier

    2012-07-01

    Full Text Available Les voix over de narration peuvent servir à effrayer les spectateurs de cinéma. Depuis les bonimenteurs-conférenciers des salles d’avant 1914, jusqu’aux films d’horreur des années 1970, en passant par les films des années 1930 et 1940, les voix placées sur des images peuvent créer une atmosphère lugubre. Le contraste entre une voix susurrée et des images pleines de suspens, est générateur d’angoisse. Des exemples tirés de films de Lang, Hitchcock, Tourneur, ou de cinéastes bien moins connus, permettent de vérifier que les voix over s’intègrent dans une longue tradition mais qu’elles évoluent constamment.Voice over can be use to frighten movie audiences. From the film lecturer before 1914 to the 1970s Horror movies, voices accompanying images can create a gloomy atmosphere. Contrast between suspenseful images and a whispering voice can generate fear. With examples taken from Lang, Hitchcock, Tourneur, and unknown directors, we will show that voice over creates fear since a long tradition. But each time it evolves in a different way.

  19. Mujer, trabajo y persistencia del maíz

    Directory of Open Access Journals (Sweden)

    Erika Román Montes de Oca

    2013-01-01

    Full Text Available El presente artículo se elaboró con la intención de destacar el lugar que ocupan las mujeres en la sociedad de Amatlán de Quetzalcóatl, tomando para ello como punto principal el trabajo que realizan y el papel que cumplen en la unidad familiar al incidir en la permanencia del maíz en la comunidad y en la trasmisión de los valores para dicha persistencia. Se encontró que a pesar de prevalecer una familia con estructura patriarcal en el seno familiar, la mujer ocupa un lugar de respeto y unión, aportando opiniones y decisiones que son valoradas. También se vislumbran factores de cambio en la comunidad y en la actividad de las mujeres hacia ámbitos extra domésticos. Para este trabajo se realizaron 95 encuestas a nivel de la unidad familiar y diez entrevistas a profundidad.

  20. Personal Hygiene Practices among Urban Homeless Persons in Boston, MA.

    Science.gov (United States)

    Leibler, Jessica H; Nguyen, Daniel D; León, Casey; Gaeta, Jessie M; Perez, Debora

    2017-08-18

    Persons experiencing homelessness in the United States experience significant barriers to self-care and personal hygiene, including limited access to clean showers, laundry and hand washing facilities. While the obstacles to personal hygiene associated with homelessness may increase risk of infectious disease, hygiene-related behaviors among people experiencing homelessness has received limited attention. We conducted a cross-sectional study of individuals experiencing homelessness in Boston, MA ( n = 194) to identify hygiene-related self-care practices and risk factors for reduced hygiene in this population. Most participants (72%) reported taking a daily shower. More than 60% reported hand washing with soap five or more times each day, and use of hand sanitizer was widespread (89% reported using sanitizer in the last week). A majority (86%) used a laundromat or laundry machine to wash clothing, while 14% reported washing clothing in the sink. Heavy drinking, injection drug use, and sleeping outdoors were identified as significant risk factors for reduced hygiene practices. People experiencing homelessness who also engage in these activities may be among the most difficult to reach for intervention, yet targeted efforts may decrease illness risk associated with reduced hygiene. Housed friends and family play a critical role in assisting homeless individuals maintain hygiene by providing showers and laundry facilities.

  1. Proposal MaMBA - Moon and Mars Base Analog

    Science.gov (United States)

    Heinicke, Christiane; Foing, Bernard

    2017-04-01

    Despite impressive progress in robotic exploration of celestial bodies, robots are believed to never reach the effectiveness and efficiency of a trained human. Consequently, ESA proposes to build an international Moon Village in roughly 15 years and NASA plans for the first manned mission to Mars shortly after. One of the challenges still remaining is the need for a shelter, a habitat which allows human spacefarers to safely live and work on the surface of a celestial body. Although various prototype habitats have been built and inhabited during the last decade, they typically share two fundamental flaws: First, they usually consist of a single space, which may become uninhabitable after depressurization due to just one single catastrophic event. Second, none of the habitats provides shielding against radiation, one of the major health concerns for spacefaring crews. Project MaMBA will address these two problems at the root and build an underground habitat comprised of five connected, but independent modules. The habitat will serve for testing technologies like life support, power systems, and interplanetary communication. Special attention will be given to the development of the geoscience laboratory module. In addition to the technological aspects, the envisioned habitat will serve as a unique test ground for studies on the effects of underground habitation on a crew.

  2. Regioselective hydroxylation of isoflavones by Streptomyces avermitilis MA-4680.

    Science.gov (United States)

    Roh, Changhyun; Seo, Su-Hyun; Choi, Kwon-Young; Cha, Minho; Pandey, Bishnu Prasad; Kim, June-Hyung; Park, Jun-Seong; Kim, Duck Hee; Chang, Ih Seop; Kim, Byung-Gee

    2009-07-01

    Screening of bacterial whole cells was performed for regioselective hydroxylation of daidzein and genistein. Among the strains examined, Streptomyces avermitilis MA-4680 showed high ortho-dihydroxylation activity to produce 3',4',7-trihydroxyisoflavone and 3',4',5,7-tetrahydroxyisoflavone from daidzein (4',7-dihydroxyisoflavone) and genistein (4',5,7-trihydroxyisoflavone), respectively. Using 100 mg cells (wet wt.) and 1% (v/v) Triton X100 in 1 ml of total reaction volume, where 100 microl of the substrate solution (0.5 mM in 10% (v/v) mixed solvent of DMSO:MeOH = 3:7) was added to 900 microl of potassium phosphate buffer (100 mM, pH 7.2), a 16% molar conversion yield of 3',4',7-trihydroxyisoflavone was obtained from 0.5 mM daidzein after 24 h of reaction time at 28 degrees C and 200 rpm. Ketoconazole significantly (ca. 90%) inhibited the ortho-hydroxylation activity of daidzein, suggesting that cytochrome P450 enzymes putatively play roles in regiospecific daidzein hydroxylation. The analysis of the reaction products was determined by gas chromatography/mass spectrometry (GC/MS) and (1)H NMR.

  3. 78 FR 7663 - SLR; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

    Science.gov (United States)

    2013-02-04

    ... 1625-AA08 SLR; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands... special local regulations on the waters of St. Thomas Harbor in St. Thomas, U. S. Virgin Islands during... through March 24, 2013, the St. Thomas Yacht Club is sponsoring the 2013 Rolex Regatta, a series of sail...

  4. 78 FR 22778 - Safety Zone; Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S.V.I.

    Science.gov (United States)

    2013-04-17

    ...-AA00 Safety Zone; Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S.V.I. AGENCY: Coast Guard... waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands during the Corp. Event Finale UHC, a... barge being positioned near the St. Thomas Harbor channel from which fireworks will be lit. The safety...

  5. 78 FR 23489 - Safety Zone; V.I. Carnival Finale, St. Thomas Harbor; St. Thomas, U.S.V.I.

    Science.gov (United States)

    2013-04-19

    ...-AA00 Safety Zone; V.I. Carnival Finale, St. Thomas Harbor; St. Thomas, U.S.V.I. AGENCY: Coast Guard... waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands during the V.I. Carnival Finale, a... being positioned near the St. Thomas Harbor channel from which fireworks will be lit. The safety zone is...

  6. 78 FR 16208 - Safety Zone; V. I. Carnival Finale; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

    Science.gov (United States)

    2013-03-14

    ... 1625-AA00 Safety Zone; V. I. Carnival Finale; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands AGENCY... establish a safety zone on the waters of St. Thomas Harbor in St. Thomas, U. S. Virgin Islands during the V..., 2013, and will entail a barge being positioned near the St. Thomas Harbor channel from which fireworks...

  7. 78 FR 16211 - Safety Zone, Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

    Science.gov (United States)

    2013-03-14

    ... 1625-AA00 Safety Zone, Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S. Virgin Islands... establish a temporary safety zone on the waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands... near the St. Thomas Harbor channel from which fireworks will be lit. DATES: Comments and related...

  8. Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2, a co-activator of CREB.

    Science.gov (United States)

    Lee, Jinwoo; Tong, Tiegang; Takemori, Hiroshi; Jefcoate, Colin

    2015-06-15

    In mouse steroidogenic cells the activation of cholesterol metabolism is mediated by steroidogenic acute regulatory protein (StAR). Here, we visualized a coordinated regulation of StAR transcription, splicing and post-transcriptional processing, which are synchronized by salt inducible kinase (SIK1) and CREB-regulated transcription coactivator (CRTC2). To detect primary RNA (pRNA), spliced primary RNA (Sp-RNA) and mRNA in single cells, we generated probe sets by using fluorescence in situ hybridization (FISH). These methods allowed us to address the nature of StAR gene expression and to visualize protein-nucleic acid interactions through direct detection. We show that SIK1 represses StAR expression in Y1 adrenal and MA10 testis cells through inhibition of processing mediated by CRTC2. Digital image analysis matches qPCR analyses of the total cell culture. Evidence is presented for spatially separate accumulation of StAR pRNA and Sp-RNA at the gene loci in the nucleus. These findings establish that cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  9. NuMA is required for the proper completion of mitosis

    Science.gov (United States)

    1993-01-01

    NuMA is a 236-kD intranuclear protein that during mitosis is distributed into each daughter cell by association with the pericentrosomal domain of the spindle apparatus. The NuMA polypeptide consists of globular head and tail domains separated by a discontinuous 1500 amino acid coiled-coil spacer. Expression of human NuMA lacking its globular head domain results in cells that fail to undergo cytokinesis and assemble multiple small nuclei (micronuclei) in the subsequent interphase despite the appropriate localization of the truncated NuMA to both the nucleus and spindle poles. This dominant phenotype is morphologically identical to that of the tsBN2 cell line that carries a temperature-sensitive mutation in the chromatin-binding protein RCC1. At the restrictive temperature, these cells end mitosis without completing cytokinesis followed by micronucleation in the subsequent interphase. We demonstrate that the wild-type NuMA is degraded in the latest mitotic stages in these mutant cells and that NuMA is excluded from the micronuclei that assemble post-mitotically. Elevation of NuMA levels in these mutant cells by forcing the expression of wild-type NuMA is sufficient to restore post-mitotic assembly of a single normal-sized nucleus. Expression of human NuMA lacking its globular tail domain results in NuMA that fails both to target to interphase nuclei and to bind to the mitotic spindle. In the presence of this mutant, cells transit through mitosis normally, but assemble micronuclei in each daughter cell. The sum of these findings demonstrate that NuMA function is required during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. PMID:8432734

  10. Galleria mellonella infection model demonstrates high lethality of ST69 and ST127 uropathogenic E. coli.

    Directory of Open Access Journals (Sweden)

    Majed F Alghoribi

    Full Text Available Galleria mellonella larvae are an alternative in vivo model for investigating bacterial pathogenicity. Here, we examined the pathogenicity of 71 isolates from five leading uropathogenic E. coli (UPEC lineages using G. mellonella larvae. Larvae were challenged with a range of inoculum doses to determine the 50% lethal dose (LD50 and for analysis of survival outcome using Kaplan-Meier plots. Virulence was correlated with carriage of a panel of 29 virulence factors (VF. Larvae inoculated with ST69 and ST127 isolates (10(4 colony-forming units/larvae showed significantly higher mortality rates than those infected with ST73, ST95 and ST131 isolates, killing 50% of the larvae within 24 hours. Interestingly, ST131 isolates were the least virulent. We observed that ST127 isolates are significantly associated with a higher VF-score than isolates of all other STs tested (P≤0.0001, including ST69 (P<0.02, but one ST127 isolate (strain EC18 was avirulent. Comparative genomic analyses with virulent ST127 strains revealed an IS1 mediated deletion in the O-antigen cluster in strain EC18, which is likely to explain the lack of virulence in the larvae infection model. Virulence in the larvae was not correlated with serotype or phylogenetic group. This study illustrates that G. mellonella are an excellent tool for investigation of the virulence of UPEC strains. The findings also support our suggestion that the incidence of ST127 strains should be monitored, as these isolates have not yet been widely reported, but they clearly have a pathogenic potential greater than that of more widely recognised clones, including ST73, ST95 or ST131.

  11. Altersgruppen in städtischen Teilräumen : theoretische Grundlagen, empirische Untersuchungen und verwaltungspraktische Anwendungen am Beispiel der Kleinstadt Drolshagen

    OpenAIRE

    Schwalbach, Gerrit

    2016-01-01

    Altersgruppen spielen in der Diskussion um den „Demografischer Wandel“ eine zentrale Rolle, ohne dass dabei die Kriterien bzw. die konstituierenden Rahmenbedingungen zur Definition von Altersgruppen geklärt werden. Ferner bleibt ungeklärt, welche Wirkzusammenhänge durch unterschiedliche Relationen von Altersgruppen ausgelöst werden und auf welchen räumlichen Maßstabsebenen diese relevant sind. Grundsätzlich stehen demografische Dynamiken und deren Bewertungen in wechselseitigen Beziehungen zu...

  12. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Race Point, MA, to Watch Hill, RI... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill... and Rhode Island from Race Point to Watch Hill. (b) A line drawn from Nobska Point Light to Tarpaulin...

  13. NuMA expression and function in mouse oocytes and early embryos.

    Science.gov (United States)

    Tang, Chieh-Ju C; Hu, Hui-Mei; Tang, Tang K

    2004-01-01

    Nuclear mitotic apparatus protein (NuMA), originally described as a nuclear protein, is an essential component in the formation and maintenance of mitotic spindle poles. In this study, we analyze the expression pattern and function of NuMA in mouse oocytes and early embryos. In germinal vesicle-stage oocytes, NuMA was detected both at the centrosome and in the nucleus. However, after nuclear maturation and extrusion of the first polar body, NuMA was concentrated at the broad meiotic spindle poles and at cytasters (centers of cytoplasmic microtubule asters) of mature metaphase II oocytes. Cold-induced depolymerization of microtubules appeared to disassociate NuMA foci from the cytoplasmic cytasters. During fertilization, NuMA was relocated into the re-formed male and female pronuclei. Microinjection of anti-NuMA antibody into 1 of 2 cells of 2-cell-stage embryos inhibited normal cell division. These results suggest that NuMA might play an important role in cell division during early embryonic mitosis. Copyright 2004 National Science Council, ROC and S. Karger AG, Basel

  14. Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle.

    Science.gov (United States)

    Chu, Xiaogang; Chen, Xuanyu; Wan, Qingwen; Zheng, Zhen; Du, Quansheng

    2016-09-16

    The large nuclear mitotic apparatus (NuMA) protein is an essential player in mitotic spindle assembly and maintenance. We report here the identification of Astrin, a spindle- and kinetochore-associated protein, as a novel interactor of NuMA. We show that the C-terminal tail of NuMA can directly bind to the C terminus of Astrin and that this interaction helps to recruit Astrin to microtubules. Knockdown of NuMA by RNA interference dramatically impaired Astrin recruitment to the mitotic spindle. Overexpression of the N terminus of mammalian homologue of Drosophila Pins (LGN), which blocks the microtubule binding of NuMA and competes with Astrin for NuMA binding, also led to similar results. Furthermore, we found that cytoplasmic dynein is required for the spindle pole accumulation of Astrin, and dynein-mediated transport is important for balanced distribution of Astrin between spindle poles and kinetochores. On the other hand, if Astrin levels are reduced, then NuMA could not efficiently concentrate at the spindle poles. Our findings reveal a direct physical link between two important regulators of mitotic progression and demonstrate the critical role of the NuMA-Astrin interaction for accurate cell division. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  15. Cell cycle-dependent SUMO-1 conjugation to nuclear mitotic apparatus protein (NuMA).

    Science.gov (United States)

    Seo, Jae Sung; Kim, Ha Na; Kim, Sun-Jick; Bang, Jiyoung; Kim, Eun-A; Sung, Ki Sa; Yoon, Hyun-Joo; Yoo, Hae Yong; Choi, Cheol Yong

    2014-01-03

    Covalent conjugation of proteins with small ubiquitin-like modifier 1 (SUMO-1) plays a critical role in a variety of cellular functions including cell cycle control, replication, and transcriptional regulation. Nuclear mitotic apparatus protein (NuMA) localizes to spindle poles during mitosis, and is an essential component in the formation and maintenance of mitotic spindle poles. Here we show that NuMA is a target for covalent conjugation to SUMO-1. We find that the lysine 1766 residue is the primary NuMA acceptor site for SUMO-1 conjugation. Interestingly, SUMO modification of endogenous NuMA occurs at the entry into mitosis and this modification is reversed after exiting from mitosis. Knockdown of Ubc9 or forced expression of SENP1 results in impairment of the localization of NuMA to mitotic spindle poles during mitosis. The SUMOylation-deficient NuMA mutant is defective in microtubule bundling, and multiple spindles are induced during mitosis. The mitosis-dependent dynamic SUMO-1 modification of NuMA might contribute to NuMA-mediated formation and maintenance of mitotic spindle poles during mitosis. Copyright © 2013 Elsevier Inc. All rights reserved.

  16. NuMA is required for the selective induction of p53 target genes.

    Science.gov (United States)

    Ohata, Hirokazu; Miyazaki, Makoto; Otomo, Ryo; Matsushima-Hibiya, Yuko; Otsubo, Chihiro; Nagase, Takahiro; Arakawa, Hirofumi; Yokota, Jun; Nakagama, Hitoshi; Taya, Yoichi; Enari, Masato

    2013-06-01

    The p53 tumor suppressor protein is a transcription factor controlling various outcomes, such as growth arrest and apoptosis, through the regulation of different sets of target genes. The nuclear mitotic apparatus protein (NuMA) plays important roles in spindle pole organization during mitosis and in chromatin regulation in the nucleus during interphase. Although NuMA has been shown to colocalize with several nuclear proteins, including high-mobility-group proteins I and Y and GAS41, the role of NuMA during interphase remains unclear. Here we report that NuMA binds to p53 to modulate p53-mediated transcription. Acute and partial ablation of NuMA attenuates the induction of the proarrested p21 gene following DNA damage, subsequently causing impaired cell cycle arrest. Interestingly, NuMA knockdown had little effect on the induction of the p53-dependent proapoptotic PUMA gene. Furthermore, NuMA is required for the recruitment of cyclin-dependent kinase 8 (Cdk8), a component of the Mediator complex and a promoter of p53-mediated p21 gene function. These data demonstrate that NuMA is critical for the target selectivity of p53-mediated transcription.

  17. NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.

    Science.gov (United States)

    Kotak, Sachin; Busso, Coralie; Gönczy, Pierre

    2014-08-18

    The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gαi1-3 anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper spindle positioning. The mechanisms governing cortical localization of NuMA and dynein during anaphase remain more elusive. Here, we report that LGN/Gαi1-3 are dispensable for NuMA-dependent cortical dynein enrichment during anaphase. We further establish that NuMA is excluded from the equatorial region of the cell cortex in a manner that depends on the centralspindlin components CYK4 and MKLP1. Importantly, we reveal that NuMA can directly associate with PtdInsP (PIP) and PtdInsP2 (PIP2) phosphoinositides in vitro. Furthermore, chemical or enzymatic depletion of PIP/PIP2 prevents NuMA cortical localization during mitosis, and conversely, increasing PIP2 levels augments mitotic cortical NuMA. Overall, our study uncovers a novel function for plasma membrane phospholipids in governing cortical NuMA distribution and thus the proper execution of mitosis. © 2014 The Authors.

  18. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping... Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...°31.2′ W. (Cape Ann Lighted Whistle Buoy “2”). ...

  19. O HOMEM QUE QUERIA SER REI: Uma Aventura Maçônica

    OpenAIRE

    Freitas Neto, Edgard da Costa

    2014-01-01

    O presente trabalho busca demonstrar a influência da filosofia e do simbolismo maçônico presentesno conto “O homem que queria ser Rei”, de Rudyard Kipling, ressaltando as lições maçônicas que sepodem extrair daquela obra.

  20. European Master's Program in Gerontology (EuMaG): Goals, Curriculum, and Students

    Science.gov (United States)

    Aartsen, Marja

    2011-01-01

    The European Master's Program in Gerontology (EuMaG) started in September 2003 with support from the European Commission. The EuMaG is a modular, 2-year, part-time international training program about the aging process and its societal implications. The multidisciplinary curriculum comprises four domains of gerontology (i.e., social gerontology,…

  1. European Master's program in Gerontology (EuMaG): Goals, curriculum, and students

    NARCIS (Netherlands)

    Aartsen, M.J.

    2011-01-01

    The European Master's Program in Gerontology (EuMaG) started in September 2003 with support from the European Commission. The EuMaG is a modular, 2-year, part-time international training program about the aging process and its societal implications. The multidisciplinary curriculum comprises four

  2. Patent Analysis for Supporting Merger and Acquisition (M&A) Prediction: A Data Mining Approach

    Science.gov (United States)

    Wei, Chih-Ping; Jiang, Yu-Syun; Yang, Chin-Sheng

    M&A plays an increasingly important role in the contemporary business environment. Companies usually conduct M&A to pursue complementarity from other companies for preserving and/or extending their competitive advantages. For the given bidder company, a critical first step to the success of M&A activities is the appropriate selection of target companies. However, existing studies on M&A prediction incur several limitations, such as the exclusion of technological variables in M&A prediction models and the omission of the profile of the respective bidder company and its compatibility with candidate target companies. In response to these limitations, we propose an M&A prediction technique which not only encompasses technological variables derived from patent analysis as prediction indictors but also takes into account the profiles of both bidder and candidate target companies when building an M&A prediction model. We collect a set of real-world M&A cases to evaluate the proposed technique. The evaluation results are encouraging and will serve as a basis for future studies.

  3. 46 CFR 308.522 - Collateral deposit fund, letter of transmittal, Form MA-302.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Collateral deposit fund, letter of transmittal, Form MA... Collateral deposit fund, letter of transmittal, Form MA-302. The standard form of letter of transmittal for use in establishing a collateral deposit fund, may be obtained from the American War Risk Agency or...

  4. Expression analysis of banana MaECHI1 during fruit ripening with ...

    African Journals Online (AJOL)

    ... banana ethylene production and MaECHI1 gene expression peaks appeared earlier with ethylene treatment than with other treatment. MaECHI1 gene expression was markedly responsive to the fruit ripening process and to exogenous ethylene treatment. Keywords: Banana (Musa acuminata L.AAA), endochitinase gene ...

  5. Liberal Arts in China's Modern Universities: Lessons from the Great Catholic Educator and Statesman, Ma Xiangbo

    Science.gov (United States)

    Jiang, You Guo

    2012-01-01

    Ma Xiangbo was born in 1840 and became a pioneer of educational reform during the republican period. He was responsible for introducing the idea that science and humanities should be valued equally in liberal arts education, a concept that became key to the model of university education. Ma's view of education combined Western humanism and science…

  6. 46 CFR 308.529 - Surety Bond B, Form MA-309.

    Science.gov (United States)

    2010-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.529 Surety Bond B, Form MA-309. An Assured who elects to substitute a surety bond for a collateral deposit fund shall submit Form MA-309...

  7. Festivals de cinéma dans le monde arabe

    Directory of Open Access Journals (Sweden)

    Jean-Michel Frodon

    2013-12-01

    Full Text Available Alors que les deux grands festivals « historiques » du monde arabe, Carthage (JCC et Le Caire, sont entrés en décadence, on assiste depuis le début des années 2000 à une véritable explosion du phénomène festivalier dans le monde arabe. Le pays le plus en pointe est le Maroc, quoique de manière contrastée, avec une manifestation de prestige à Marrakech, et une nuée de petites manifestations. Dans les émirats du Golfe, la multiplication des festivals traduit une stratégie de communication plutôt qu’une volonté de développement culturel. Cette stratégie est fragilisée par la concurrence que se livrent les différents acteurs. Dans les autres pays arabes, on trouve une grande variété de situations sous le signe de la dispersion. Pourtant, l’accumulation de festivals (une centaine dans la région finit par avoir des effets d’ensemble, au-delà des buts, moyens et limites de chacun d’eux. Le phénomène festivalier, bien qu’inscrit dans des agendas locaux ou nationaux, génère de manière plus vaste des réseaux générationnels, financiers, de procédures d’expertise, de processus d’interrelation, géographiques mais aussi entre le cinéma et les autres arts ou médias.

  8. Global subduction volume fluxes over the past 200 Ma

    Science.gov (United States)

    Heine, C.; Butterworth, N. P.; Quevedo, L. E.; Müller, D.

    2013-12-01

    The volume of subducted oceanic lithosphere changes over geological time as seafloor of different mean age distributions is subducted at with different rates. This has potential implications for the spatio-temporal dynamics of mantle convection and especially dynamic topography induced by negatively buoyant material in the mantle as well as the time-dependence of the related mantle return flow. We use global plate kinematic models and paleooceanic age grids to analyse the subduction volume fluxes over the past 200 Million years and compare our results with global mantle convection models and observations from seismic tomography and key regions which are known to have experienced significant changes in vertical motions due to mantle convection-induced dynamic topography. Two distinct patterns of subduction are found related to the motion of the overriding plate: a localised volume flux, characteristic for relatively stationary subduction around southern and eastern Eurasia and a widely distributed volume flux, predominately for the North and South American Pacific subduction zones where oceanic slabs of varying age have been subducted over wide regions. Subduction zones around Antarctica and the SW Pacific range between both end-members types. We find that the global subduction volume flux decreases substantially from a peak with of around 6.5*10^6 km^3/Myr around the Base Cretaceous to volumes fluxes of around 3.0*10^6 km^3/Myr, reflecting a long-term decrease in oceanic crustal production. In addition we find peaks in global subduction volume flux around 125, 55 and 20 Ma, whose origin can be related to the regional evolution of particular subduction systems.

  9. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2009-08-28

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program (HEDP) which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee (HPDAC) which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving changes to all chapters in the document. Revision numbers that include a decimal fraction reflect minor revisions, usually restricted to selected chapters or selected pages in the document.

  10. Mercury Cycling in Salt Marsh Pond Ecosystems: Cape Cod, MA

    Science.gov (United States)

    Ganguli, P. M.; Gonneea, M. E.; Lamborg, C. H.; Kroeger, K. D.; Swarr, G.; Vadman, K. J.; Baldwin, S.; Brooks, T. W.; Green, A.

    2014-12-01

    We are measuring total mercury (HgT) and monomethylmercury (CH3Hg+ or MMHg) in pore water, surface water, and sediment cores from two salt marsh pond systems on the south shore of Cape Cod, MA to characterize the distribution of mercury species and to identify features that influence mercury speciation and transport. Sage Lot Pond is relatively undisturbed and has low nitrogen loading (12 kg ha-1 y-1). It is part of the Waquoit Bay National Estuarine Reserve and is surrounded by undeveloped wooded uplands. In contrast, Great Pond is highly impacted. Nitrogen loading to the site is elevated (600 kg ha-1 y-1) and the marsh is adjacent to a large residential area. In both systems, a 1 to 2 m organic-rich peat layer overlies the permeable sand aquifer. Groundwater in this region is typically oxic, where pore water within salt marsh peat is suboxic to anoxic. We hypothesize that redox gradients at the transition from the root zone to peat and at the peat-sand interface may provide habitat for MMHg-producing anaerobic bacteria. Preliminary results from a 2-m nearshore depth profile at Sage Lot Pond indicate HgT in groundwater within the sand aquifer occurred primarily in the > 0.2 μm fraction, with unfiltered concentrations exceeding 100 pM. Filtered (fraction of filtered HgT in peat pore water. Although MMHg in both groundwater and pore water remained around 1 pM throughout our depth profile, we observed an increase in sediment MMHg (0.3 to 1.6 μg/kg) at the peat-sand interface. MMHg comprised ~50% of the HgT concentration in pore water suggesting mercury in the salt marsh peat is biologically available.

  11. Requirements for NuMA in maintenance and establishment of mammalian spindle poles.

    Science.gov (United States)

    Silk, Alain D; Holland, Andrew J; Cleveland, Don W

    2009-03-09

    Microtubules of the mitotic spindle in mammalian somatic cells are focused at spindle poles, a process thought to include direct capture by astral microtubules of kinetochores and/or noncentrosomally nucleated microtubule bundles. By construction and analysis of a conditional loss of mitotic function allele of the nuclear mitotic apparatus (NuMA) protein in mice and cultured primary cells, we demonstrate that NuMA is an essential mitotic component with distinct contributions to the establishment and maintenance of focused spindle poles. When mitotic NuMA function is disrupted, centrosomes provide initial focusing activity, but continued centrosome attachment to spindle fibers under tension is defective, and the maintenance of focused kinetochore fibers at spindle poles throughout mitosis is prevented. Without centrosomes and NuMA, initial establishment of spindle microtubule focusing completely fails. Thus, NuMA is a defining feature of the mammalian spindle pole and functions as an essential tether linking bulk microtubules of the spindle to centrosomes.

  12. NuMA Phosphorylation by Aurora-A Orchestrates Spindle Orientation.

    Science.gov (United States)

    Gallini, Sara; Carminati, Manuel; De Mattia, Fabiola; Pirovano, Laura; Martini, Emanuele; Oldani, Amanda; Asteriti, Italia Anna; Guarguaglini, Giulia; Mapelli, Marina

    2016-02-22

    Spindle positioning is essential for tissue morphogenesis and homeostasis. The signaling network synchronizing spindle placement with mitotic progression relies on timely recruitment at the cell cortex of NuMA:LGN:Gαi complexes, in which NuMA acts as a receptor for the microtubule motor Dynein. To study the implication of Aurora-A in spindle orientation, we developed protocols for the partial inhibition of its activity. Under these conditions, in metaphase NuMA and Dynein accumulate abnormally at the spindle poles and do not reach the cortex, while the cortical distribution of LGN remains unperturbed. FRAP experiments revealed that Aurora-A governs the dynamic exchange between the cytoplasmic and the spindle pole-localized pools of NuMA. We show that Aurora-A phosphorylates directly the C terminus of NuMA on three Ser residues, of which Ser1969 determines the dynamic behavior and the spindle orientation functions of NuMA. Most interestingly, we identify a new microtubule-binding domain of NuMA, which does not overlap with the LGN-binding motif. Our study demonstrates that in metaphase the direct phosphorylation of NuMA by Aurora-A controls its cortical enrichment, and that this is the major event underlying the spindle orientation functions of Aurora-A in transformed and non-transformed cells in culture. Phosphorylation of NuMA by Aurora-A does not affect its affinity for microtubules or for LGN but rather determines the mobility of the protein at the spindle poles. The finding that NuMA can associate concomitantly with LGN and microtubules suggests that its microtubule-binding activity contributes to anchor Dynein-loaded microtubule +TIPs at cortical sites with LGN. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Tiešsaistes GPS izsekošanas sistēma „GPS OrientTracker”

    OpenAIRE

    Āboliņš, Valters

    2008-01-01

    Darba mērķis bija ieviest Latvijā GPS tiešsaistes izsekošanas sistēmu, kas orientēšanās sacensību laikā spētu uzrādīt, kur atrodas konkrēta persona uz doto brīdi. Tā kā Pasaulē šāda veida sistēmas jau tiek pielietotas, arī Latvijā, lai attīstītu un popularizētu orientēšanās sportu, ir nepieciešamas tiešsaistes izsekošanas sistēmas. Rezultātā tika salīdzinātas jau esošas sistēmas, to cenas, un izvēlēta piemērotākā uztvērējierīce, un beigās izstrādāta tiešsaistes izsekošanas sistēma....

  14. The ARIES-ST study: Assessment of the spherical tokamak concept as fusion power plants

    International Nuclear Information System (INIS)

    Najmabadi, F.; Tillack, M.; Miller, R.; Mau, T.K.; Jardin, S.; Stambaugh, R.; Steiner, D.; Waganer, L.

    2001-01-01

    Recent experimental achievements and theoretical studies have generated substantial interest in the spherical tokamak concept. The ARIES-ST study was undertaken as a national U.S. effort to investigate the potential of the spherical tokamak concept as a fusion power plant and as a vehicle for fusion development. The 1000-MWe ARIES-ST power plant has an aspect ratio of 1.6, a major radius of 3.2 m, a plasma elongation (at 95% flux surface) of 3.4 and triangularity of 0.64. This configuration attains a β of 54% (which is 90% of the maximum theoretical β). While the plasma current is 31 MA, the almost perfect alignment of bootstrap and equilibrium current density profiles results in a current-drive power of only 31 MW. The on-axis toroidal field is 2.1 T and the peak field at the TF coil is 7.6 T, which leads to 288 MW of Joule losses in the normal-conducting TF system. The ARIES-ST study has highlighted many areas where tradeoffs among physics and engineering systems are critical in determining the optimum regime of operation for spherical tokamaks. Many critical issues also have been identified which must be resolved in R and D programs. (author)

  15. ST peak during percutaneous coronary intervention serves as an early prognostic predictor in patients with ST-segment elevation myocardial

    DEFF Research Database (Denmark)

    Lønborg, Jacob; Kelbæk, Henning; Engstrøm, Thomas

    2014-01-01

    AIMS: To evaluate the clinical importance of the ST peak phenomenon during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS: Continuous ST monitoring was performed in 942 STEMI patients from arrival until 90...... minutes after revascularisation. ST peak was defined as ≥1 mm increase in the ST-segment during PCI compared with the ST elevation before intervention. ST peak was observed in 26.9% of patients. During median follow-up of 4.1 years, 20.7% of patients experienced a major adverse cardiac event (MACE). ST...

  16. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2007-03-12

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program (HEDP) which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee (HPDAC) which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. Rev. 0 marks the first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database. Revision numbers that are whole numbers reflect major revisions typically involving changes to all chapters in the document. Revision numbers that include a decimal fraction reflect minor revisions, usually restricted to selected chapters or selected pages in the document. Revision Log: Rev. 0 (2/25/2005) Major revision and expansion. Rev. 0.1 (3/12/2007) Minor

  17. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2010-04-01

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at the U.S. Department of Energy (DOE) Hanford site. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with requirements of 10 CFR 835, the DOE Laboratory Accreditation Program, the DOE Richland Operations Office, DOE Office of River Protection, DOE Pacific Northwest Office of Science, and Hanford’s DOE contractors. The dosimetry system is operated by the Pacific Northwest National Laboratory (PNNL) Hanford External Dosimetry Program which provides dosimetry services to PNNL and all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since its inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving significant changes to all chapters in the document. Revision

  18. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2011-04-04

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at the U.S. Department of Energy (DOE) Hanford site. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with requirements of 10 CFR 835, the DOE Laboratory Accreditation Program, the DOE Richland Operations Office, DOE Office of River Protection, DOE Pacific Northwest Office of Science, and Hanford’s DOE contractors. The dosimetry system is operated by the Pacific Northwest National Laboratory (PNNL) Hanford External Dosimetry Program which provides dosimetry services to PNNL and all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since its inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving significant changes to all chapters in the document. Revision

  19. Urbanization in 21st century.

    Science.gov (United States)

    Altarejos, R G

    1990-01-01

    Due to a combination of rapid population growth and high levels of rural-urban migration, overcrowding will be common in many cities around the world in the 21st century. Currently at 5.3 billion, the global population is expected to increase to 6 billion by the year 2000, and to 9 billion by 2025. Experts predict that urban centers will bear the brunt of the population growth. Rural areas have seen declines in the standard of living, partly due to natural disasters, civil war, and economic policies favoring urban centers. In search of jobs, better access to education, and health services, rural populations will flock to cities. But the rapid growth of cities will inevitably lead to the creation of slums, which will hamper urban development. Urban demographers predict that by the end of the century, 1/2 of the world's population will be urban, and 1/5 of these people will be concentrated in "mega cities," populations of 4 million or more. International migration will play a significant role, as people cross borders in search of opportunity. But contrary to the traditional model of urban growth, much of it will take place in developing countries. According to a 1985 study, developed nations had an urbanization level of 71%, compared to 31% in developing countries. However, experts calculate that by 2025, these levels will practically even out, with an urbanization level of 74% for developing countries and 77% for developed countries. By 2025, 25 cities will have populations of over 9 million, including Mexico City (25.8), Sao Paulo (24.0), Tokyo (20.2), Calcutta (16.5), Greater Bombay (16.0), and New York (15.8).

  20. Integrable quantum Stäckel systems

    International Nuclear Information System (INIS)

    Błaszak, Maciej; Domański, Ziemowit; Sergyeyev, Artur; Szablikowski, Błażej M.

    2013-01-01

    The Stäckel separability of a Hamiltonian system is well known to ensure existence of a complete set of Poisson commuting integrals of motion quadratic in the momenta. We consider a class of Stäckel separable systems where the entries of the Stäckel matrix are monomials in the separation variables. We show that the only systems in this class for which the integrals of motion arising from the Stäckel construction keep commuting after quantization are, up to natural equivalence transformations, the so-called Benenti systems. Moreover, it turns out that the latter are the only quantum separable systems in the class under study.

  1. Specification For ST-5 Li Ion Battery

    Science.gov (United States)

    Castell, Karen D.; Day, John H. (Technical Monitor)

    2000-01-01

    This Specification defines the general requirements for rechargeable Space Flight batteries intended for use in the ST-5 program. The battery chemistry chosen for this mission is lithium ion (Li-Ion).

  2. Location - Managed Facility - St. Paul District (MVP)

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — St. Paul District - US Army Corps of Engineers Managed Facility locations. District headquarters, Natural Resource, Recreation, Lock and Dam, and Regulatory offices...

  3. Control Strategy Tool (CoST)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EPA Control Strategy Tool (CoST) is a software tool for projecting potential future control scenarios, their effects on emissions and estimated costs. This tool...

  4. 2014 Lidar DEM: St. Charles Parish (LA)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Under this task order, Precision Aerial Reconnaissance, LLC was contracted to provide acquisition and processing of airborne Lidar over St. Charles Parish,...

  5. Nursing research in the 21 st century

    Directory of Open Access Journals (Sweden)

    Roger Watson

    2013-01-01

    Conclusion: Nursing research has developed greatly over the past century and continues to develop in the 21 st century. Nursing research is relevant to the needs of patients and has had an impact on clinical practice.

  6. 2008 St. Johns County, FL Countywide Lidar

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Airborne terrestrial LiDAR was collected for St. Johns County, FL. System Parameters/Flight Plan. The LiDAR system acquisition parameters were developed based on a...

  7. Meteor detection on ST (MST) radars

    International Nuclear Information System (INIS)

    Avery, S.K.

    1987-01-01

    The ability to detect radar echoes from backscatter due to turbulent irregularities of the radio refractive index in the clear atmosphere has lead to an increasing number of established mesosphere - stratosphere - troposphere (MST or ST) radars. Humidity and temperature variations are responsible for the echo in the troposphere and stratosphere and turbulence acting on electron density gradients provides the echo in the mesosphere. The MST radar and its smaller version, the ST radar, are pulsed Doppler radars operating in the VHF - UHF frequency range. These echoes can be used to determine upper atmosphere winds at little extra cost to the ST radar configuration. In addition, the meteor echoes can supplement mesospheric data from an MST radar. The detection techniques required on the ST radar for delineating meteor echo returns are described

  8. St. John's Wort (Hypericum Perforatum) and Pregnancy

    Science.gov (United States)

    ... amount of time it takes your body to eliminate half of the dose of the medication). It ... 2006. St. John’s wort (Hypericum perforatum) and breastfeeding: plasma and breast milk concentrations of hyperforin for 5 ...

  9. Fossil fuels in the 21st century.

    Science.gov (United States)

    Lincoln, Stephen F

    2005-12-01

    An overview of the importance of fossil fuels in supplying the energy requirements of the 21st century, their future supply, and the impact of their use on global climate is presented. Current and potential alternative energy sources are considered. It is concluded that even with substantial increases in energy derived from other sources, fossil fuels will remain a major energy source for much of the 21st century and the sequestration of CO2 will be an increasingly important requirement.

  10. St Sava and the cloud-chasers

    OpenAIRE

    Loma Aleksandar

    2013-01-01

    A gloss in the Nomocanon of St Sava condemns folk superstitions related to magically provoking hailstorms and eclipses. St Sava’s miracle with the king of Hungary as described in his Vitae seems to go back to the same complex of popular beliefs. Its acceptance by the hagiography was probably due to the influence of the figure of prince magician as common to the Serbian and the Russian oral epics.

  11. St Sava and the cloud-chasers

    Directory of Open Access Journals (Sweden)

    Loma Aleksandar

    2013-01-01

    Full Text Available A gloss in the Nomocanon of St Sava condemns folk superstitions related to magically provoking hailstorms and eclipses. St Sava’s miracle with the king of Hungary as described in his Vitae seems to go back to the same complex of popular beliefs. Its acceptance by the hagiography was probably due to the influence of the figure of prince magician as common to the Serbian and the Russian oral epics.

  12. Echt und modern? Diskurse über Männlichkeit

    Directory of Open Access Journals (Sweden)

    Florian Kahofer

    2014-09-01

    Full Text Available Der vorliegende Artikel befasst sich mit Repräsentationen von Männlichkeit im österreichischen Lifestyle-Magazin für Männer Wiener. Durch eine korpusbasierte Diskursanalyse wird ein umfassendes Korpus aller Ausgaben des Wieners von Anfang 2002 bis Ende 2012 untersucht. Auf theoretischer Ebene wird dabei eine Verbindung von Kritischer Männlichkeitsforschung (KMF und Feministisch Kritischer Diskursanalyse (FCDA unternommen. Es werden aktuelle Veröffentlichungen zu Kritischer Diskursanalyse und Männlichkeit vorgestellt und diskutiert. Durch den Einsatz einer Konkordanzsoftware werden Konkordanzen des Nomens MANN analysiert. Diese werden allerdings insofern eingeschränkt betrachtet, als nur Nominationen in der Form der häufigsten Adjektiv-Konstruktionen untersucht werden. Die Ergebnisse zeigen, dass neben den Diskursen über Krise und Neue Männlichkeit Themen wie Alter, Körper oder Beziehung auftauchen. Männlichkeit wird als ambivalent und vielfältig dargestellt. Deutungskämpfe um Männlichkeit lassen sich ausmachen.

  13. Convective removal of the Tibetan Plateau mantle lithosphere by 26 Ma

    Science.gov (United States)

    Lu, Haijian; Tian, Xiaobo; Yun, Kun; Li, Haibing

    2018-04-01

    During the late Oligocene-early Miocene there were several major geological events in and around the Tibetan Plateau (TP). First, crustal shortening deformation ceased completely within the TP before 25 Ma and instead adakitic rocks and potassic-ultrapotassic volcanics were emplaced in the Lhasa terrane since 26-25 Ma. Several recent paleoelevation reconstructions suggest an Oligocene-early Miocene uplift of 1500-3000 m for the Qiangtang (QT) and Songpan-Ganzi (SG) terranes, although the exact timing is unclear. As a possible response to this uplift, significant desertification occurred in the vicinity of the TP at 26-22 Ma, and convergence between India and Eurasia slowed considerably at 26-20 Ma. Subsequently, E-W extension was initiated no later than 18 Ma in the Lhasa and QT terranes. In contrast, the tectonic deformation around the TP was dominated by radial expansion of shortening deformation since 25-22 Ma. The plateau-wide near-synchroneity of these events calls for an internally consistent model which can be best described as convective removal of the lower mantle lithosphere. Geophysical and petrochemical evidence further confirms that this extensive removal occurred beneath the QT and SG terranes. The present review concludes that, other than plate boundary stress, the internal stress within the TP lithosphere could have contributed to rapid wholesale uplift and a series of concomitant tectonic events, accompanied by major aridification, since 26 Ma.

  14. Diversity in early crustal evolution: 4100 Ma zircons in the Cathaysia Block of southern China.

    Science.gov (United States)

    Xing, Guang-Fu; Wang, Xiao-Lei; Wan, Yusheng; Chen, Zhi-Hong; Jiang, Yang; Kitajima, Kouki; Ushikubo, Takayuki; Gopon, Phillip

    2014-06-03

    Zircons are crucial to understanding the first 500 Myr of crustal evolution of Earth. Very few zircons of this age (>4050 Ma) have been found other than from a ~300 km diameter domain of the Yilgarn Craton, Western Australia. Here we report SIMS U-Pb and O isotope ratios and trace element analyses for two ~4100 Ma detrital zircons from a Paleozoic quartzite at the Longquan area of the Cathaysia Block. One zircon ((207)Pb/(206)Pb age of 4127 ± 4 Ma) shows normal oscillatory zonation and constant oxygen isotope ratios (δ(18)O = 5.8 to 6.0‰). The other zircon grain has a ~4100 Ma magmatic core surrounded by a ~4070 Ma metamorphic mantle. The magmatic core has elevated δ(18)O (7.2 ± 0.2‰), high titanium concentration (53 ± 3.4 ppm) and a positive cerium anomaly, yielding anomalously high calculated oxygen fugacity (FMQ + 5) and a high crystallization temperature (910°C). These results are unique among Hadean zircons and suggest a granitoid source generated from dry remelting of partly oxidizing supracrustal sediments altered by surface waters. The ~4100 Ma dry melting and subsequent ~4070 Ma metamorphism provide new evidence for the diversity of the Earth's earliest crust.

  15. Mere zaštite pri eksploataciji mašina i opreme za aplikaciju pesticida

    OpenAIRE

    Dimitrovski, Zoran; Kukutanov, Risto; Gligorevic, Kosta; Oljaca, Mico

    2016-01-01

    Direktiva 2009/128/EC Evropskog parlamenta određuje okvir za sprovođenje Nacionalnog akcionog plana u svakoj državi, koji se odnosi na održljivoj upotrebi pesticida. Jedan deo directive dierktno uređuje upotrebu mašina i opreme za aplikaciju pesticida kao i njihovo pravilno i bezbedno korištenje. Imajuči u vidu da u Republici Makedoniji inspekcija i obuka farmera za pravilno i bezbedno korištenje ovih mašina nisu obavezne, javljaju se problemi oko održavanja mašina i trovanj...

  16. RuleMaDrone: A Web-Interface to Visualise Space Usage Rules for Drones

    OpenAIRE

    Trippaers, Aäron

    2015-01-01

    RuleMaDrone, an application developed within this thesis, is presented as a solution to communicate the rules and regulations to drone operators. To provide the solution a framework for drone safety was designed which consists of the rules and regulations, the drone properties and the environmental factors. RuleMaDrone is developed with this framework and thus will provide drone operators with an application which they can use to find a safe and legal fly zone. RuleMaDrone u...

  17. Amelioration durable du rendement de maïs a travers des varietes et ...

    African Journals Online (AJOL)

    L'utilisation de variétés appropriées et la maximisation de l'efficience d'utilisation de l'azote (N) sont nécessaires pour améliorer durablement le rendement en grain du maïs (Zea mays L.). La présente étude a porté sur trois variétés de maïs et a été conduite au cours des deux saisons de production du maïs au sud du Togo ...

  18. Impact of M&A on the Employment in Japanese Companies

    OpenAIRE

    Hiroyuki Taguchi; Taichi Yanagawa; Masashi Harita

    2012-01-01

    With utilizing Financial Statements Statistics of Corporation by Industry, we analyzed the impact of M&A on the employment in Japanese companies. In this study, the impact of M&A on the employment was extracted by developing panel data for fiscal year 1995 to 2008 targeting 9,880 sample companies including 3,697 cases of M&A to estimate a labor demand model. Major findings of the study are described below. First, dynamically positive effect was confirmed mainly in the manufacturing industry a...

  19. Caractérisation des systemes de production à base de maïs dans ...

    African Journals Online (AJOL)

    La présente recherche vise à caractériser les systèmes de production à base de maïs au Bénin pour un appui-conseil ciblé aux producteurs de maïs. La base de sondage est la base de données du sous-projet "Centre National de Spécialisation sur le Maïs", exécuté par l'Institut National des Recherches Agricoles du Bénin ...

  20. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2010-01-01

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program (HEDP) which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee (HPDAC) which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since its inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving significant changes to all chapters in the document. Revision numbers that include a decimal fraction reflect minor revisions, usually restricted to selected chapters or selected pages in the document. Maintenance and distribution of controlled hard copies of the

  1. St. James marine terminal facility description

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    The US Department of Energy (DOE) currently owns and operates a marine terminal on the west bank of the Mississippi River at St. James, Louisiana. The St. James facility was constructed by the Department to provide marine services associated with the fill and drawdown of the Strategic Petroleum Reserve (SPR) crude oil storage facilities located at Bayou Choctaw and Weeks Island, Louisiana. Although strategic to the mission of the SPR in the event of a national emergency, the St. James terminal is situated such that it has a high potential to also serve the commercial industry`s needs for crude oil terminalling and storage. The St. James terminal is located approximately 45 miles west of New Orleans and 30 miles southeast of Baton Rouge, and approximately 160 miles upstream from the mouth of the Mississippi River. Construction of the St. James terminal was initiated in 1978 and was completed in 1980. Since then, the terminal has received and transferred over 125 million barrels of crude oil to the SPR sites for storage. For crude oil distribution, the St. James terminal was connected to the neighboring LOCAP terminal by a 0.1 mile 36-inch pipeline in 1981 and to the Capline terminal by a 0.5 mile 30-inch pipeline in 1988. The terminal also has a 30-inch pipeline connection to the Koch oil terminal which was used for initial fill purposes; however, this pipeline has been disconnected and is currently inactive. A complete description of the St. James terminal facilities, operational capabilities, operational certifications, and future Government requirements are presented in Sections 2, 3, 4, and 5 respectively.

  2. 76 FR 68101 - Safety Zone; Art Gallery Party St. Pete 2011 Fireworks Display, Tampa Bay, St. Petersburg, FL

    Science.gov (United States)

    2011-11-03

    ... [Docket No. USCG-2011-0774] RIN 1625-AA00 Safety Zone; Art Gallery Party St. Pete 2011 Fireworks Display... St. Petersburg, Florida during the Art Gallery Party St. Pete 2011 Fireworks Display on Friday... November 11, 2011, Creative Pyrotechnics is sponsoring the Art Gallery Party St. Pete 2011 Fireworks...

  3. 78 FR 16780 - Special Local Regulation; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S...

    Science.gov (United States)

    2013-03-19

    ... 1625-AA08 Special Local Regulation; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U... is establishing special local regulations on the waters of St. Thomas Harbor in St. Thomas, U. S.... Thomas Yacht Club is sponsoring the 2013 Rolex Regatta, a series of sail boat races. The races will be...

  4. Contact Aligner 1 (Front and Back Side): Suss Microtec MA6

    Data.gov (United States)

    Federal Laboratory Consortium — Description:CORAL Name: SussMA6This system utilizes 1X contact lithography to transfer photomask patterns onto substrates Specifications / Capabilities:UV broadmand...

  5. "Ma sinna istutaks need lilled punased..." : [luuletused] / [Ptshelovodova, Nadezhda] Muš Nadii ; tlk. Arvo Valton

    Index Scriptorium Estoniae

    Muš Nadii, pseud., 1976-

    2006-01-01

    Sisu: "Ma sinna istutaks need lilled punased..." ; "Ei kõik hinged tõuse taevasse..." ; Kuum öö ; Kas tunned ; Ojamaa ; Magnoolia ; 24.02.2005 ; Päike vaatab tagasi. Luuletused paralleelselt udmurdi ja eesti keeles

  6. Klasifikasi Kecamatan Berdasarkan Nilai Akhir SMA/MA di Kabupaten Aceh Selatan Menggunakan Analisis Diskriminan

    Directory of Open Access Journals (Sweden)

    Fitriana A.R.

    2015-11-01

    Full Text Available Analisis diskriminan merupakan bagian dari analisis peubah ganda. Analisis diskriminan digunakan untuk memodelkan variabel tak bebas yang bersifat kualitatif dengan variabel bebas yang bersifat kuantitatif. Pada penelitian ini, analisis diskriminan lebih dari dua kelompok diterapkan pada data nilai akhir SMA/MA di Kabupaten Aceh Selatan yang bertujuan untuk mendapatkan model untuk pengklasifikasian kecamatan. Pengklasifikasian ini bertujuan untuk melihat perbedaan kualitas siswa SMA/MA yang berada di masing-masing kecamatan Kabupaten Aceh Selatan berdasarkan data nilai akhir. Variabel tak bebas yang digunakan berupa klasifikasi kecamatan berdasarkan rata-rata jumlah nilai akhir SMA/MA yang berada di masing-masing kecamatan yang dibentuk dengan K-Means Cluster. Sedangkan variabel bebas yang digunakan adalah data rata-rata nilai akhir SMA/MA untuk setiap mata pelajaran yang diujiankan pada masing-masing jurusan setiap kecamatan. Model yang didapatkan adalah dua model diskriminan untuk jurusan IPA dan IPS.

  7. Design of an upgradeable 45-100 mA RFQ accelerator for FAIR

    International Nuclear Information System (INIS)

    Zhang Chuan; Schempp, Alwin

    2009-01-01

    A 325 MHz, 35 mA, 3 MeV Radio-Frequency Quadrupole (RFQ) accelerator will be operated as the first accelerating structure of the proton linac injector for the newly planned international science center Facility for Antiproton and Ion Research (FAIR) at GSI, Germany. In previous design studies, two high beam intensities, 70 and 100 mA, were used. Most recently, the design intensity has been changed to 45 mA, which is closer to the operational value. Taking advantage of the so-called New Four-Section Procedure, a new design, which is upgradable from 45 to 100 mA, has been developed for the FAIR proton RFQ. Besides the upgradability analyses, robustness studies of the new design to spatial displacements of the input beam and field errors are presented as well.

  8. Production, biochemical characterization and detergents application of keratinase from the marine actinobacterium Actinoalloteichus sp. ma-32.

    Digital Repository Service at National Institute of Oceanography (India)

    Manivasagan, P.; Sivakumar, K.; Gnanam, S.; Venkatesan, J.; Kim, S.-K.

    and culture conditions for the keratinase production by Actinoalloteichus sp. MA-32 were optimized using two statistical methods: Plackett–Burman design was applied to find the key ingredients and conditions for the best yield of enzyme production and central...

  9. The Mesoscale Science of the Matter-Radiation Interactions in Extremes (MaRIE) project

    Energy Technology Data Exchange (ETDEWEB)

    Kippen, Karen Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Montoya, Donald Raymond [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-17

    The National Nuclear Security Administration (NNSA) requires the ability to understand and test how material structures, defects, and interfaces determine performance in extreme environments such as in nuclear weapons. To do this, MaRIE will be an x-ray source that is laser-like and brilliant with very fl exible and fast pulses to see at weapons-relevant time scales, and with high enough energy to study critical materials. The Department of Energy (DOE) has determined there is a mission need for MaRIE to deliver this capability. MaRIE can use some of the existing infrastructure of the Los Alamos Neutron Science Center (LANSCE) and its accelerator capability. MaRIE will be built as a strategic partnership of DOE national laboratories and university collaborators.

  10. EnviroAtlas - New Bedford, MA - Meter-Scale Urban Land Cover (MULC) Data (2010)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The New Bedford, MA Meter-Scale Urban Land Cover (MULC) data were generated from United States Department of Agriculture (USDA) National Agricultural Imagery Program...

  11. Kui ma oleksin minister : abiturient 2005 soovitab / Urve Läänemets

    Index Scriptorium Estoniae

    Läänemets, Urve

    2006-01-01

    Inglise keele riigieksami essee "Kui ma oleksin haridusminister..." põhjal läbi viidud uuringust, mis kajastab rohkem kui kahe tuhande Eesti abituriendi arvamusi ja ettepanekuid koolielu edendamiseks

  12. Microstructural evolution and mechanical properties of friction stir welded ODS alloy MA754

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jiye; Yuan, Wei [Center for Friction Stir Processing, Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla, MO 65409 (United States); Mishra, Rajiv S., E-mail: Rajiv.Mishra@unt.edu [Center for Friction Stir Processing, Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla, MO 65409 (United States); Department of Materials Science and Engineering, University of North Texas, Denton, TX 76203 (United States); Charit, Indrajit [Department of Chemical and Materials Engineering, University of Idaho, Moscow, ID 83844 (United States)

    2013-11-15

    Microstructural evolution and mechanical properties of MA754, an yttrium oxide dispersion-strengthened nickel-based superalloy, were investigated after friction stir welding (FSW). A tool rotation rate of 1000 revolution per minute and a traverse speed of 50.8 mm per minute were employed using a cermet (WC–Co) tool. After FSW, fine equiaxed grain structure with a high dislocation density and a random texture was achieved. Agglomeration of yttrium oxide dispersoids was observed in FSW MA754. Room-temperature tensile properties of FSW MA754 were compared to those of as-received MA754 alloy, and the results indicated that particle strengthening contribution decreased as a result of dispersoid agglomeration.

  13. The Role of the st313-td Gene in Virulence of Salmonella Typhimurium ST313

    DEFF Research Database (Denmark)

    Herrero-Fresno, Ana; Wallrodt, Inke; Leekitcharoenphon, Pimlapas

    2014-01-01

    Multidrug-resistant Salmonella enterica serovar Typhimurium ST313 has emerged in sub-Saharan Africa causing severe infections in humans. Therefore, it has been speculated that this specific sequence type, ST313, carries factors associated with increased pathogenicity. We assessed the role...

  14. St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1/3 arc-second St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model will be used to support NOAA's tsunami forecast system and for...

  15. The marine Algal Vegetation of St. Martin, St. Eustatius and Saba (Netherlands Antilles)

    NARCIS (Netherlands)

    Vroman, M.

    1968-01-01

    Along the coast of St. Martin, St. Eustatius and Saba the rocks above sea-level often show a number of differently coloured zones. This is clearly visible when the coast over a larger distance is formed by one type of rock, as for instance on Saba. In many places a light-coloured belt is seen above

  16. ST depression in lead aVL differentiates inferior ST-elevation myocardial infarction from pericarditis.

    Science.gov (United States)

    Bischof, Johanna E; Worrall, Christine; Thompson, Peter; Marti, David; Smith, Stephen W

    2016-02-01

    ST-segment elevation (STE) due to inferior STE myocardial infarction (STEMI) may be misdiagnosed as pericarditis. Conversely, this less life-threatening etiology of ST elevation may be confused for inferior STEMI. We sought to determine if the presence of any ST-segment depression in lead aVL would differentiate inferior STEMI from pericarditis. Retrospective study of 3 populations. Cohort 1 included patients coded as inferior STEMI, cohort 2 included patients with a discharge diagnosis of pericarditis who presented with chest pain and at least 0.5 mm of ST elevation in at least 1 inferior lead. We analyzed the presenting electrocardiogram in both populations, with careful assessment of leads II, III, aVF, and aVL. In addition, we retrospectively studied a third cohort of patients with subtle inferior STEMI (pericarditis group, all 49 had some inferior STE but none had any ST-segment depression in lead aVL (specificity, 100%; confidence interval, 91%-100%). In the third cohort, there were 272 inferior MIs with coronary occlusion, of which 54 were "subtle." Of these, 49 had some ST depression in lead aVL. When there is inferior ST-segment elevation, the presence of any ST depression in lead aVL is highly sensitive for coronary occlusion in inferior myocardial infarction and very specific for differentiating inferior myocardial infarction from pericarditis. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Three members of Medicago truncatula ST family are ubiquitous during development and modulated by nutritional status (MtST1) and dehydration (MtST2 and MtST3).

    Science.gov (United States)

    Albornos, Lucía; Martín, Ignacio; Labrador, Emilia; Dopico, Berta

    2017-07-10

    ShooT specific/Specific Tissue (ST) belong to a protein family of unknown function characterized by the DUF2775 domain and produced in specific taxonomic plant families, mainly Fabaceae and Asteraceae, with the Medicago truncatula ST family being the largest. The putative roles proposed for this family are cell elongation, biotic interactions, abiotic stress and N reserve. The aim of this work was to go deeper into the role of three M. truncatula ST proteins, namely ST1, ST2 and ST3. Our starting hypothesis was that each member of the family could perform a specific role, and hence, each ST gene would be subjected to a different type of regulation. The search for cis-acting regulatory elements (CREs) in silico in pST1, pST2 and pST3 promoters showed prevalence of tissue/organ specific motifs, especially root- and seed-specific ones. Light, hormone, biotic and abiotic related motifs were also present. None of these pSTs showed the same combination of CREs, or presented the same activity pattern. In general, pST activity was associated with the vascular cylinder, mainly in roots. Promoter activation was highly specific and dissimilar during reproductive development. The ST1, ST2 and ST3 transcripts accumulated in most of the organs and developmental stages analysed - decreasing with age - and expression was higher in the roots than in the aerial parts and more abundant in light-grown plants. The effect of the different treatments on transcript accumulation indicated that ST1 behaved differently from ST2 and ST3, mainly in response to several hormones and dehydration treatments (NaCl or mannitol), upon which ST1 transcript levels decreased and ST2 and ST3 levels increased. Finally, the ST1 protein was located in the cell wall whereas ST2 and ST3 were present both in the cytoplasm and in the cell wall. The ST proteins studied are ubiquitous proteins that could perform distinct/complementary roles in plant biology as they are encoded by differentially regulated genes

  18. Study on holographic characteristics in ZnMA doped PQ-PMMA photopolymer

    Science.gov (United States)

    Yu, Dan; Liu, Hongpeng; Wang, Jian; Jiang, Yongyuan; Sun, Xiudong

    2011-06-01

    The holographic characteristics in phenanthrenequinone and Zinc methylacrylate doped poly-(methyl methacrylate) photopolymers are experimentally studied. The role of ZnMA molecules which is to accelerate the photochemical reaction in material is confirmed by experiment. The doping of ZnMA component results in a higher diffraction efficiency and photosensitivity than typical phenanthrenequinone doped poly-(methyl methacrylate) system. Moreover, the response region and dynamic range are obviously improved.

  19. TRANSFORMASI KURIKULUM PESANTREN: Telaah Pemikiran KH. MA. Sahal Mahfudh dan Nurcholish Madjid

    OpenAIRE

    Mukhlison Effendi; Suradi Suradi

    2016-01-01

    Abstract; Islamic boarding school is an indigenous Indonesia. Some contribution that given in the Islamization process, create a good community literacy and culture are very large. One reason, because there are Islamic boarding school curriculum transformation. Most influential enticement are KH. MA. Sahal Mahfudh and Nurcholish Madjid enticement. To knowing and determine the transformation both of those figures, the researcher take focus of study as: 1) the speculation of KH. MA. Sahal Mahfu...

  20. Effect of the mechanical processing on the mechanical properties of MA956 alloy. II. Mechanical characterization

    International Nuclear Information System (INIS)

    Chao, J.; Gonzalez-Doncel, G.

    1998-01-01

    The mechanical properties at room and low temperature of MA 956 alloy in some stages of their processing route are evaluated. In this study the influence of crystallographic orientation on plastic deformation and brittle fracture, strongly anisotropic phenomena, is also considered. It is concluded that even though MA 956 alloy was designated for high temperature applications it could be also used for cryogenic temperatures applications. (Author) 8 refs

  1. Radiation hardening and irradiation testing of in-cell electronics for MA23/APM

    International Nuclear Information System (INIS)

    Friant, A.

    1988-09-01

    We relate briefly the radiation hardening method used to guarantee a gamma resistance of 10 Mrad for the whole electronic equipment associated with the slave arm of MA23 M servomanipulator which will be set up in cell 404 in Marcoule (APM). We describe the radiation testing of electronic devices and of the various subsystems designed by the D. LETI groups involved in the MA23/APM project

  2. Producción de forraje con maíz criollo y maíz híbrido

    Directory of Open Access Journals (Sweden)

    Jorge Elizondo

    2002-01-01

    Full Text Available Con el fin de conocer el rendimiento productivo de forraje de dos cultivares de maíz: híbrido y criollo, evaluados a igual edad y luego en similar estado fisiológico, sembrados a diferentes distancias entre plantas, se llevó a cabo un experimento en la Estación Experimental Alfredo Volio Mata de la Universidad de Costa Rica, ubicada a una altitud de 1542 msnm, con una precipitación media anual de 2050 mm. Se determinó en ambos cultivares, que la producción de materia seca (kg/ha, reflejó un incremento al disminuir la distancia entre plantas. El cultivar repercutió notablemente sobre los rendimientos productivos. Los rendimientos en base seca (kg/ha fueron 30% mayores en maíz criollo que en maíz hí- brido cuando se comparan a una misma edad. Cuando se comparan ambos cultivares en igual estado fisiológico, los rendimientos en base seca (kg/ha son 37% superiores en el cultivar criollo. La altura promedio de la planta fue 1,7 m mayor en el cultivar criollo que en el híbrido. No se encontraron diferencias significativas en cuanto a rendimientos de biomasa verde o seca, ni en cuanto al contenido de materia seca al comparar el maíz criollo por edad y por estado fisiológico.

  3. Bacillibactin and Bacillomycin Analogues with Cytotoxicities against Human Cancer Cell Lines from Marine Bacillus sp. PKU-MA00093 and PKU-MA00092.

    Science.gov (United States)

    Zhou, Mengjie; Liu, Fawang; Yang, Xiaoyan; Jin, Jing; Dong, Xin; Zeng, Ke-Wu; Liu, Dong; Zhang, Yingtao; Ma, Ming; Yang, Donghui

    2018-01-10

    Nonribosomal peptides from marine Bacillus strains have received considerable attention for their complex structures and potent bioactivities. In this study, we carried out PCR-based genome mining for potential nonribosomal peptides producers from our marine bacterial library. Twenty-one "positive" strains were screened out from 180 marine bacterial strains, and subsequent small-scale fermentation, HPLC and phylogenetic analysis afforded Bacillus sp. PKU-MA00092 and PKU-MA00093 as two candidates for large-scale fermentation and isolation. Ten nonribosomal peptides, including four bacillibactin analogues ( 1 - 4 ) and six bacillomycin D analogues ( 5 - 10 ) were discovered from Bacillus sp. PKU-MA00093 and PKU-MA00092, respectively. Compounds 1 and 2 are two new compounds and the ¹H NMR and 13 C NMR data of compounds 7 and 9 is first provided. All compounds 1 - 10 were assayed for their cytotoxicities against human cancer cell lines HepG2 and MCF7, and the bacillomycin D analogues 7 - 10 showed moderate cytotoxicities with IC 50 values from 2.9 ± 0.1 to 8.2 ± 0.2 µM. The discovery of 5 - 10 with different fatty acid moieties gave us the opportunity to reveal the structure-activity relationships of bacillomycin analogues against these human cancer cell lines. These results enrich the structural diversity and bioactivity properties of nonribosomal peptides from marine Bacillus strains.

  4. VaST: A variability search toolkit

    Science.gov (United States)

    Sokolovsky, K. V.; Lebedev, A. A.

    2018-01-01

    Variability Search Toolkit (VaST) is a software package designed to find variable objects in a series of sky images. It can be run from a script or interactively using its graphical interface. VaST relies on source list matching as opposed to image subtraction. SExtractor is used to generate source lists and perform aperture or PSF-fitting photometry (with PSFEx). Variability indices that characterize scatter and smoothness of a lightcurve are computed for all objects. Candidate variables are identified as objects having high variability index values compared to other objects of similar brightness. The two distinguishing features of VaST are its ability to perform accurate aperture photometry of images obtained with non-linear detectors and handle complex image distortions. The software has been successfully applied to images obtained with telescopes ranging from 0.08 to 2.5 m in diameter equipped with a variety of detectors including CCD, CMOS, MIC and photographic plates. About 1800 variable stars have been discovered with VaST. It is used as a transient detection engine in the New Milky Way (NMW) nova patrol. The code is written in C and can be easily compiled on the majority of UNIX-like systems. VaST is free software available at http://scan.sai.msu.ru/vast/.

  5. Silencing of Nuclear Mitotic Apparatus protein (NuMA) accelerates the apoptotic disintegration of the nucleus.

    Science.gov (United States)

    Kivinen, Katri; Taimen, Pekka; Kallajoki, Markku

    2010-08-01

    One main feature of apoptosis is the sequential degradation of the nuclear structure, including the fragmentation of chromatin and caspase-mediated cleavage of various nuclear proteins. Among these proteins is the Nuclear Mitotic Apparatus protein (NuMA) which plays a specific role in the organization of the mitotic spindle. The exact function of NuMA in the interphase nucleus is unknown, but a number of reports have suggested that it may play a role in chromatin organization and/or gene expression. Here we show that upon cleavage in apoptotic cells, the N-terminal cleavage fragment of NuMA is solubilized while the C-terminal fragment remains associated with the condensed chromatin. Using pancaspase inhibitor z-VAD-fmk and caspase-3 deficient MCF-7 cells, we further show that the solubilization is dependent on caspase-mediated cleavage of NuMA. Finally, the silencing of NuMA by RNAi accelerated nuclear breakdown in apoptotic MCF-7 cells. These results suggest that NuMA may provide structural support in the interphase nucleus by contributing to the organization of chromatin.

  6. Periodic modulations controlling Kuznetsov–Ma soliton formation in nonlinear Schrödinger equations

    Energy Technology Data Exchange (ETDEWEB)

    Tiofack, C.G.L., E-mail: glatchio@yahoo.fr [Univ. Lille, CNRS, UMR 8523 – PhLAM – Physique des Lasers Atomes et Molécules, F-59000 Lille (France); Coulibaly, S.; Taki, M. [Univ. Lille, CNRS, UMR 8523 – PhLAM – Physique des Lasers Atomes et Molécules, F-59000 Lille (France); De Bièvre, S.; Dujardin, G. [Univ. Lille, CNRS, UMR 8524 – Laboratoire Paul Painlevé, F-59000 Lille (France); Équipe-Projet Mephysto, INRIA Lille-Nord Europe (France)

    2017-06-28

    We analyze the exact Kuznetsov–Ma soliton solution of the one-dimensional nonlinear Schrödinger equation in the presence of periodic modulations satisfying an integrability condition. We show that, in contrast to the case without modulation, the Kuznetsov–Ma soliton develops multiple compression points whose number, shape and position are controlled both by the intensity of the modulation and by its frequency. In addition, when this modulation frequency is a rational multiple of the natural frequency of the Kuznetsov–Ma soliton, a scenario similar to a nonlinear resonance is obtained: in this case the spatial oscillations of the Kuznetsov–Ma soliton's intensity are periodic. When the ratio of the two frequencies is irrational, the soliton's intensity is a quasiperiodic function. A striking and important result of our analysis is the possibility to suppress any component of the output spectrum of the Kuznetsov–Ma soliton by a judicious choice of the amplitude and frequency of the modulation. - Highlights: • Exact Kuznetsov–Ma soliton solution in presence of periodic coefficients is obtained. • The multiple compression points of the solution are studied. • The quasi-periodicity of the solution is discussed. • The possibility to suppress any component of the spectrum is analyzed.

  7. Correlating The Star Formation Histories Of MaNGA Galaxies With Their Past AGN Activity

    Science.gov (United States)

    Gonzalez Ortiz, Andrea

    2017-01-01

    We investigate active galactic nuclei (AGN) as a primary mechanism affecting star formation in MaNGA galaxies. Using the Pipe3D code, we modeled the stellar population from MaNGA spectra and derived the star formation histories of 53 AGN host galaxies. We seek to compare the star formation histories of the host galaxies of AGN with the ages of their radio lobes to better understand the role of AGN feedback in the star formation histories of MaNGA galaxies. MaNGA (Mapping Nearby Galaxies at APO) is one of the three core programs in the fourth generation Sloan Digital Sky Survey(SDSS). MaNGA will investigate the internal kinematics of nearly 10,000 local galaxies through dithered observations using fiber integral field units (IFUs) that vary in diameter from 12" (19 fibers) to 32" (127 fibers). In this poster, we present initial results on the star formation histories of MaNGA AGN host galaxies. This work was supported by the SDSS Research Experience for Undergraduates program, which is funded by a grant from Sloan Foundation to the Astrophysical Research Consortium.

  8. Draft Genome Sequences of Staphylococcus aureus AMRF1 (ST22) and AMRF2 (ST672), Ocular Methicillin-Resistant Isolates

    KAUST Repository

    Velusamy, Nithya

    2014-03-20

    Sequence type 22 (ST22) and ST672 are the two major emerging clones of community-acquired methicillin-resistant Staphylococcus aureus in India. ST672 strains were found to cause severe ocular infections. We report the draft genome sequences of two emerging strains of methicillin-resistant S. aureus, AMRF1 (ST22) and AMRF2 (ST672), isolated from patients with ocular infections.

  9. Phosphorylation of NuMA by Aurora-A kinase in PC-3 prostate cancer cells affects proliferation, survival, and interphase NuMA localization.

    Science.gov (United States)

    Toughiri, Raheleh; Li, Xiang; Du, Quansheng; Bieberich, Charles J

    2013-04-01

    Aurora-A is a serine/threonine kinase that has oncogenic properties in vivo. The expression and kinase activity of Aurora-A are up-regulated in multiple malignancies. Aurora-A is a key regulator of mitosis that localizes to the centrosome from the G2 phase through mitotic exit and regulates mitotic spindle formation as well as centrosome separation. Overexpression of Aurora-A in multiple malignancies has been linked to higher tumor grade and poor prognosis through mechanisms that remain to be defined. Using an unbiased proteomics approach, we identified the protein nuclear mitotic apparatus (NuMA) as a robust substrate of Aurora-A kinase. Using a small molecule Aurora-A inhibitor in conjunction with a reverse in-gel kinase assay (RIKA), we demonstrate that NuMA becomes hypo-phosphorylated in vivo upon Aurora-A inhibition. Using an alanine substitution strategy, we identified multiple Aurora-A phospho-acceptor sites in the C-terminal tail of NuMA. Functional analyses demonstrate that mutation of three of these phospho-acceptor sites significantly diminished cell proliferation. In addition, alanine mutation at these sites significantly increased the rate of apoptosis. Using confocal immunofluorescence microscopy, we show that the NuMA T1804A mutant mis-localizes to the cytoplasm in interphase nuclei in a punctate pattern. The identification of Aurora-A phosphorylation sites in NuMA that are important for cell cycle progression and apoptosis provides new insights into Aurora-A function. Copyright © 2012 Wiley Periodicals, Inc.

  10. Metallic magnetic calorimeters for high resolution x-ray spectroscopy - Latest results from maXs-20 and maXs-200

    Energy Technology Data Exchange (ETDEWEB)

    Krantz, Mathaeus; Schaefer, Soenke; Pies, Christian; Hengstler, Daniel; Uhl, Simon; Georgi, Sebastian; Heuser, Sebastian; Wolf, Thomas; Kempf, Sebastian; Gastaldo, Loredana; Fleischmann, Andreas; Enss, Christian [Kirchhoff-Institut fuer Physik, Uni Heidelberg, INF 227, 69120 Heidelberg (Germany)

    2013-07-01

    We are developing metallic magnetic calorimeters (MMC) for high resolution x-ray spectroscopy on highly charged ions in the energy range up to 200 keV. MMCs use a paramagnetic temperature sensor, read-out by a SQUID, to measure the energy deposited by single X-ray photons. The recently micro-fabricated and tested prototypes include two linear 8-pixel detector arrays, maXs-20 and maXs-200, optimized for energies up to 20 keV and 200 keV, respectively. We discuss the physics of MMCs, design considerations concerning thermal and electro-magnetic cross talk, and the micro-fabrication. maXs-200 with its 1mm{sup 2} large and 200 μm thick absorbers made of electro-deposited gold has high stopping power for hard x-rays and achieves an energy resolution of 40-60 eV (FWHM). maXs-20 with its 250 μm x 250 μm large and 5 μm thick absorbers has a stopping power of 98% for 6 keV photons and presently achieves an experimental line width of 3,3 eV (FWHM), with a signal rise time of 90 ns and excellent linearity. We are presently operating maXs-20 at an electron-beam-ion-trap at the MPI-K Heidelberg and report on first atomic physics measurements as well as the particular challenges to detector operation in the vicinity of the EBIT.

  11. Dynamic distribution of NuMA and microtubules in human fetal fibroblasts, developing oocytes and somatic cell nuclear transferred embryos.

    Science.gov (United States)

    Xu, Xiaoming; Duan, Xin; Lu, Changfu; Lin, Ge; Lu, Guangxiu

    2011-05-01

    The nuclear mitotic apparatus (NuMA) plays a central role in the assembly and maintenance of spindle poles. Somatic cell nuclear transfer (SCNT) studies on non-human primates have shown that meiotic spindle removal during enucleation causes depletion of NuMA and the minus-end-directed motor protein (HSET) from the ooplasm, and this in turn leads to failure of embryo development. To determine whether NuMA from somatic cells could compensate for NuMA loss during enucleation, the distribution of NuMA and microtubule organization were investigated in human fibroblasts, developing oocytes and SCNT embryos. Human fetal fibroblasts, oocytes at various maturation stages and human embryos reconstructed by different SCNT methods were analyzed for NuMA and α-tubulin using immunofluorescent confocal microscopy. NuMA was detected in interphase nuclei of fibroblasts and oocytes. During mitosis and meiosis, NuMA relocated to the domain surrounding the two spindle poles. During the enucleation process, NuMA was removed along with the meiotic spindle. At 2 h after injection into a donor cell, transitory bipolar spindles were organized and NuMA was detected in the reformed poles. NuMA could be detected spreading uniformly across the nucleoplasm of one pseudo-pronucleus in SCNT embryos but was excluded from the nucleolus. Regardless of the method used for SCNT (enucleation-injection or injection-pronuclei enucleation), NuMA aggregated and relocated to the reformed spindle poles at metaphase of the first mitotic event. At interphase, NuMA relocated throughout the nucleus in developmentally arrested SCNT embryos. Our results show that donor cell nuclei contain NuMA, which might contribute to the maintenance of spindle morphology in SCNT embryos. Normal spindle and NuMA expression were found in human SCNT embryos at different developmental stages.

  12. Selective Reproduction in the 21st Century

    DEFF Research Database (Denmark)

    In the 21st century, human reproduction increasingly involves decisions about which gametes to fertilize, which embryos to implant, or which fetuses to abort. The term ‘selective reproduction’ refers to these increasingly widespread efforts to bring specific kinds of children into being. To this ......In the 21st century, human reproduction increasingly involves decisions about which gametes to fertilize, which embryos to implant, or which fetuses to abort. The term ‘selective reproduction’ refers to these increasingly widespread efforts to bring specific kinds of children into being...... detection of fetal anomalies during prenatal screening and testing programs, the development of preimplantation genetic diagnosis techniques as well as the screening of potential gamete donors by egg agencies and sperm banks. Selective Reproduction in the 21st Century provides unique ethnographic insights...

  13. Analyse of Maintenance Cost in ST

    CERN Document Server

    Jenssen, B W

    2001-01-01

    An analyse has been carried out in ST concerning the total costs for the division. Even though the target was the maintenance costs in ST, the global budget over has been analysed. This has been done since there is close relation between investments & consolidation and the required level for maintenance. The purpose of the analyse was to focus on maintenance cost in ST as a ratio of total maintenance costs over the replacement value of the equipment, and to make some comparisons with other industries and laboratories. Families of equipment have been defined and their corresponding ratios calculated. This first approach gives us some "quantitative" measurements. This analyse should be combined with performance indicators (more "qualitative" measurements) that are telling us how well we are performing. This will help us in defending our budget, make better priorities, and we will satisfy the requirements from our external auditors.

  14. Materials for the 21st century

    CERN Document Server

    Segal, David

    2017-01-01

    The book is a general text that shows how materials can contribute to solving problems facing nations in the 21st century. It is illustrated with diverse applications and highlights the potential of existing materials for everyday life, healthcare and the economies of nations. There are 13 chapters and a glossary of 500 materials with their descriptions, historical development, their use or potential use and a range of references. Specific areas include synthetic polymers (e.g. nylon), natural polymers (e.g. proteins, cellulose) and the role of materials in the development of digital computers and in healthcare. Solid-state lighting, energy supplies in the 21st century, disruptive technologies and intellectual property, in particular patents, are discussed. The book concludes by asking how the 21st century will be characterised. Will it be the Silicon Age, Genomic Age or New Polymer Age, as examples?

  15. Detection of methicillin-resistant Staphylococcus pseudintermedius ST169 and novel ST354 SCCmec II-III isolates related to the worldwide ST71 clone.

    Science.gov (United States)

    Ishihara, K; Koizumi, A; Saito, M; Muramatsu, Y; Tamura, Y

    2016-01-01

    The recent appearance of methicillin-resistant Staphylococcus pseudintermedius (MRSP) is a concern for both veterinary and human healthcare. MRSP clonal lineages with sequence type (ST) 71-spa t02-staphylococcal cassette chromosome mec (SCCmec) II-III and ST68-spa t06-SCCmec V have spread throughout Europe and North America, respectively. The current study compared the molecular characteristics of 43 MRSP isolates from dogs in Japan with those of MRSP from previous reports using multilocus sequence typing based on seven housekeeping genes, SCCmec typing, and detection of antimicrobial resistance genes. Three related clonal lineages, ST71, ST169, and the newly registered ST354, were observed in SCCmec II-III isolates from Japan, despite MRSP SCCmec II-III isolates being thought to belong to a single clonal lineage. The majority of SCCmec II-III isolates belonging to ST169 (9/11) and ST354 (3/3), but not ST71 (0/11), harboured tetM. Four STs were observed for the SCCmec V isolates; however, neither ST68 nor related STs were found in the Japanese MRSP isolates. In conclusion, MRSP SCCmec II-III isolates from Japan belonged to ST71 and related STs (ST169 and ST354). A variety of MRSP SCCmec V clones, including some novel clones, were identified.

  16. The 21st Century as Whose Century?

    Directory of Open Access Journals (Sweden)

    David Scott

    2015-08-01

    Full Text Available Macro-analysis and East-West encounter are shown through consideration of objective yet subjective constructed concepts for the international system and international economy in the 21st century. Three paradigms are considered, namely the 21st century as the ‘Pacific Century’, as ‘China’s Century’ and as the ‘Asian Century’. Overlaps are shown between these three paradigms, as also developments in time, and gradually shift in geographical location. The ‘Pacific Century’, and its associated Rimspeak, was the paradigm emerging in the late 1970s, knitting together America’s West Coast and the Japanese economy. By the late 1980s this was already shifting to talk of the 21st century likely to be an ‘Asian Century’ model, mark-1, based on the Pacific Asia dynamism shown by the ‘Asian Tigers’ and Japan. However, the Asian financial crash of 1997-8, and the economic downturn in Japan, meant that such an ‘Asian Century’ seemed premature as the 21st century arrived. Instead, it was China’s economic growth that seemed most evident, and with it the concept of the 21st century as ‘China’s Century’. However, in turn that has already been modified during the first decade of the century by India’s arrival as a rapidly growing economy. Consequently the 21st century as ‘China’s Century’ and as ‘India’s Century’ has been combined into talk of an ‘Asian Century’, mark-2.

  17. Omsorg/støtte i ungdomsskolen

    OpenAIRE

    Vasseng, Eli Dahl

    2012-01-01

    Master's thesis in Special education Denne studien handler om forholdet mellom lærer-elev og ser på hvordan ungdomsskoleelever beskriver omsorgsfulle/støttende lærere og den betydning det har for motivasjon i skolearbeid og læringsmiljø. Jeg har tatt utgangspunkt i ungdomsskoleelevenes forståelse av fenomenet omsorg/støtte og brukt en fenomenologisk tilnærming med intervju som metode. Seks elever fra ungdomstrinnet ble intervjuet og jeg har brukt en intervjuguide som er bygget på det teore...

  18. 51st North American Chemical Residue Workshop.

    Science.gov (United States)

    Yang, Paul; Martos, Perry; Barrett, Brad

    2015-06-03

    Manuscripts collected in this 51st North American Chemical Residue Workshop (NACRW) Symposium issue of the Journal of Agricultural and Food Chemistry (JAFC) were originally presented at the 51st NACRW meeting. The 2014 NACRW JAFC symposium collects 14 publications representing the broad range of topics in chemical analyses presented at the 2014 meeting. These include the analysis of chemical residues and contaminants in food, environment, feed, botanical, and bee samples as well as the application of quality control/quality assurance protocols in routine and method development.

  19. Statistics in the 21st century

    CERN Document Server

    Wells, Martin T; Wells, Martin T

    2001-01-01

    Exactly what is the state of the art in statistics as we move forward into the 21st century? What promises, what trends does its future hold? Through the reflections of 70 of the world's leading statistical methodologists, researchers, theorists, and practitioners, Statistics in the 21st Century answers those questions. Originally published in the Journal of the American Statistical Association, this collection of vignettes examines our statistical past, comments on our present, and speculates on our future. Although the coverage is broad and the topics diverse, it reveals the essential intell

  20. Kirjallisuuskatsaus tiimityöstä

    OpenAIRE

    Uimi, Jutta

    2012-01-01

    Laurea-ammattikorkeakoulu Tiivistelmä Laurea Lohja Hoitotyön koulutusohjelma Uimi Jutta Kirjallisuuskatsaus tiimityöstä Vuosi 2012 Sivumäärä 43 Tämän opinnäytetyön tavoitteena oli kuvata kirjallisuuskatsauksen muodossa, miten tiimityö määritellään terveydenhuollon organisaatiossa ja tiimityön käytettävyyttä sekä millaisissa yhteyksissä tiimityötä käytetään. Tarkoituksena oli tuottaa tutkittua tietoa tiimityöstä Helsingin ja Uudenmaan sairaanhoitopiiriin (HUS) kuulu...

  1. Verdens største blomsterudstilling

    DEFF Research Database (Denmark)

    Larsen, Bjarne

    2011-01-01

    Verdens største blomsterudstilling fi nder sted i udkanten af London hvert år i juli måned. Det er parken omkring det tidligere kongepalads Hampton Court palace, der danner de fantastiske omgivelser for det enorme blomster- og haveshow......Verdens største blomsterudstilling fi nder sted i udkanten af London hvert år i juli måned. Det er parken omkring det tidligere kongepalads Hampton Court palace, der danner de fantastiske omgivelser for det enorme blomster- og haveshow...

  2. Nursing theory: the 21st century.

    Science.gov (United States)

    Randell, B P

    1992-01-01

    On September 21, 1990, at the University of California, Los Angeles, Neuropsychiatric Institute and Hospital, six nurse theorists participated in a panel discussion on theory development for the 21st century. The theorists included Dorothy Johnson, Betty Neuman, Dorothea E. Orem, Rosemarie Rizzo Parse, Martha E. Rogers and Callista Roy. The panel provided the participants the opportunity to speculate on the course for future development of nursing knowledge. Three questions were posed to the panel relating to the development of their models, the direction nursing theory will take in the 21st century, and current research emerging from the extant theories. The panel also addressed questions from the audience.

  3. NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions.

    Science.gov (United States)

    Seldin, Lindsey; Poulson, Nicholas D; Foote, Henry P; Lechler, Terry

    2013-12-01

    The epidermis is a multilayered epithelium that requires asymmetric divisions for stratification. A conserved cortical protein complex, including LGN, nuclear mitotic apparatus (NuMA), and dynein/dynactin, plays a key role in establishing proper spindle orientation during asymmetric divisions. The requirements for the cortical recruitment of these proteins, however, remain unclear. In this work, we show that NuMA is required to recruit dynactin to the cell cortex of keratinocytes. NuMA's cortical recruitment requires LGN; however, LGN interactions are not sufficient for this localization. Using fluorescence recovery after photobleaching, we find that the 4.1-binding domain of NuMA is important for stabilizing its interaction with the cell cortex. This is functionally important, as loss of 4.1/NuMA interaction results in spindle orientation defects, using two distinct assays. Furthermore, we observe an increase in cortical NuMA localization as cells enter anaphase. Inhibition of Cdk1 or mutation of a single residue in NuMA mimics this effect. NuMA's anaphase localization is independent of LGN and 4.1 interactions, revealing two distinct mechanisms responsible for NuMA cortical recruitment at different stages of mitosis. This work highlights the complexity of NuMA localization and reveals the importance of NuMA cortical stability for productive force generation during spindle orientation.

  4. Mystic of St. Seraphim of Sarov and St. Francis of Assisi

    Directory of Open Access Journals (Sweden)

    Mirosław Białous

    2015-11-01

    Full Text Available This paper presents figures of St. Seraphim and St. Francis, comparing their mystic. Both saints are regarded as typical representatives of his age and his milieu: St. Seraphim – of the Eastern Orthodox Christian mystic, St. Francis – of the Christian West, the Roman Catholic mysticism. Similar was their life of poverty, similar the joy of life and the attitude towards nature, similar the ecclesial and sacramental dimension of their spirituality. But there were differences. St. Francis’ mystic is more associated with the sphere of emotional and material world, with the earthly reality. And St. Seraphim is a faithful follower of the monastic tradition of Mount Sinai, of Athos and of the other representatives of hesychasm who remaining in the earthly body experienced the spiritual liberation. These differences are visible, if we compare the experience of Christ by Seraphim on Great Thursday and the vision of St Francis on the mountain of Alvernia.

  5. Hybrid method for consistent model of the Pacific absolute plate motion and a test for inter-hotspot motion since 70Ma

    Science.gov (United States)

    Harada, Y.; Wessel, P.; Sterling, A.; Kroenke, L.

    2002-12-01

    present. We also applied the hybrid method to the African plate motion using the Tristan, St. Helena and Reunion hotspot tracks. We included the southern part of the Mascarene Plateau as the older part of the Reunion hotspot track to the model, since there is age progression along the plateau. The new model of the African absolute motion successfully explains the Ar-Ar ages and the geometry of the African hotspot tracks, and has an abrupt change at around 40 Ma. This event appears synchronous to the 43 Ma event recorded in the Pacific plate motion, and the event should therefore be considered a global one.

  6. Lithic technology of the “St Site Complex” from Peninj (Lake Natron, Tanzania: Analysis of an African Oldowan assemblage

    Directory of Open Access Journals (Sweden)

    de la Torre Sáinz, Ignacio

    2004-06-01

    Full Text Available In this work a sistematic analysis of the lithic materials from the ST Site Complex (Lake Natron, Tanzania is presented. This complex is composed of a cluster of eleven archaeological sites, which share a topographic proximity and the same stratigraphic position. They are located above Tuff 1 in the Upper Sandy Clays of the Humbu Formation of Peninj, dated around 1,6-1,4 ma. Lithic artefacts from each archaeological site will be analysed together from a technological perspective, focusing on the relevance of the conclusions obtained for knowledge of the African Oldowan.

    En este trabajo se presenta un análisis sistemático de los materiales líticos hasta ahora estudiados en el Complejo ST de Peninj, en el lago Natron (Tanzania. Este complejo está constituido por un grupo de 11 yacimientos arqueológicos muy próximos topográficamente y situados en la misma posición estratigráfica, por encima de la Toba 1 en las Upper Sandy Cáliz (Arcillas Arenosas Superiores de la Formación Humbu de Peninj, cuya cronología se estima entre los 1,6-1,4 ma. Desde una perspectiva tecnológica, se estudiarán conjuntamente los objetos líticos recuperados en cada uno de estos yacimientos, incidiendo en la relevancia de las conclusiones obtenidas para el conocimiento del Olduvayense africano.

  7. Rapid assessment of blood pressure in the obstetric day unit using Microlife MaM technology.

    Science.gov (United States)

    Wilton, Anja; De Greef, Annemarie; Shennan, Andrew

    2007-01-01

    To compare MaM technology with current methods of assessing blood pressure (BP) over time on the obstetric day unit. It is recommended that the average of repeated measures is used to confirm hypertension in pregnancy. The Microlife 3AC1 is a validated oscillometric device featuring "MaM" mode using the average of at least 3 BP readings 15 seconds apart. This allows rapid assessment of BP. The difference between each measurement is calculated and influences the percentage contribution to the final average reading. We compared MaM with readings taken in a conventional manner. Blood pressure was measured in 30 hypertensive pregnant patients recruited from the obstetric day unit of a large teaching hospital. Single BP measurements were taken at 0, 15, 30, 60, and 90 minutes using the Microlife BP 3BT0-A[2]. Simultaneous measurements (in the opposite arm) were also taken at 0 and 90 minutes using MaM technology. Systolic BP fell over 90 minutes (p = 0.035) compared with the first single reading, but diastolic BP did not (p = 0.54). The difference between the first MaM and the first single reading was significantly different for systolic BP (5.6 mm Hg, p = 0.017), but not for diastolic (0.6 mm Hg, p = 0.39). The mean of all single readings and the first MaM reading were similar for both systolic and diastolic BP (SBP:0.3 mm Hg, p = 0.75, DBP: 0.2 mm Hg, p = 0.87). White-coat hypertension exists for systolic BP in the obstetric day unit. The MaM technology allows rapid and accurate characterization of blood pressure equivalent to repeated measures over 90 minutes.

  8. Earth at 200 Ma: Global palaeogeography refined from CAMP palaeomagnetic data

    Science.gov (United States)

    Ruiz-Martínez, Vicente Carlos; Torsvik, Trond H.; van Hinsbergen, Douwe J. J.; Gaina, Carmen

    2012-05-01

    The Central Atlantic Magmatic Province was formed approximately 200 Ma ago as a prelude to the breakup of Pangea, and may have been a cause of the Triassic-Jurassic mass extinction. Based on a combination of (i) a new palaeomagnetic pole from the CAMP related Argana lavas (Moroccan Meseta Block), (ii) a global compilation of 190-210 Ma poles, and (iii) a re-evaluation of relative fits between NW Africa, the Moroccan Meseta Block and Iberia, we calculate a new global 200 Ma pole (latitude = 70.1° S, longitude = 56.7° E and A95 = 2.7°; N = 40 poles; NW Africa co-ordinates). We consider the palaeomagnetic database to be robust at 200 ± 10 Ma, which allows us to craft precise reconstructions near the Triassic-Jurassic boundary: at this very important time in Earth history, Pangea was near-equatorially centered, the western sector was dominated by plate convergence and subduction, while in the eastern sector, the Palaeotethys oceanic domain was almost consumed because of a widening Neothethys. We show that there has been negligible net displacement of the Moroccan Meseta relative to Africa since 200 Ma. We calculate a new fit between Iberia and NW Africa, showing that models inferring minor Cretaceous rotation and major Cretaceous sinistral translation of Iberia relative to Europe are inconsistent with palaeomagnetic Iberia-Africa fits at 200 Ma. During Pangea breakup (~ 195 Ma, opening of the Central Atlantic), and shortly after the CAMP outburst, Laurasia rotated clockwise relative to Gondwana around an Euler pole located in SE Iberia. The CAMP and its likely contribution to climate change, mass extinction and Pangea breakup profoundly changed planet Earth and we show that CAMP was sourced by a deep mantle plume that started its disturbing journey from the core-mantle boundary.

  9. Effects of various Prāṇāyāma on cardiovascular and autonomic variables

    Directory of Open Access Journals (Sweden)

    L Nivethitha

    2016-01-01

    Full Text Available Cardiovascular functions are controlled by neural factors, temperature, hormones, etc., Of these, neural factors primarily concern the autonomic nervous system, which plays a major role in maintaining and regulating cardiac functions, e.g., blood pressure and heart rate. Prāṇāyāma is one of the most important yogic practices. There are various review articles on Yoga and its effects but, though Prāṇāyāma is a part of yoga, there is lack of review articles. To the best of our knowledge there is no known review article on effect of various Prāṇāyāma on cardiovascular and autonomic variables. To provide a general overview about the effect of various prāṇāyāma (breathing techniques on cardiovascular and autonomic variables. A narrative review was performed based on the available scientific literature. An electronic data search was performed in Medline/PubMed database to review relevant articles, using keywords such as “Prāṇāyāma, Yogic breathing techniques, Unilateral nostril breathing, Alternate nostril breathing, Kapalbhati, Bhastrika and Bhramari Pranayama”. All the relevant articles published from 1988 to 06-04-2016 were included in this review. Slow type of yogic breathing technique was reported to produce beneficial effect on cardiovascular and autonomic variables while fast breathing techniques do not produce such effects. There is lack of consistency in the results of specific nostril yogic breathing techniques and the mechanisms behind the effects of various prāṇāyāma. This review suggests that different types of Prāṇāyāma techniques produce different effects and the mechanisms behind these effects are not fully understood.

  10. REFORMED THEOLOGY FOR THE 21ST CENTURY ...

    African Journals Online (AJOL)

    pressed in these volumes warrant a thorough and detailed study. It is not feasible to give a summary of the .... resemble the faces of consecutive generations in a family photo album: They do not look alike … They do not .... as directive the presentation of the providence of God in the Heidelberg. Catechism, even for the 21st ...

  11. Materials Testing in the 21st Century

    Science.gov (United States)

    1988-10-01

    34, Proceedings of the 31st Sagamore Army Materials Research Conference, Plenum Press, NY, 603 pp. (1986). 30. Clay Olaf Ruud and Robert E. Green, Jr., eds...Fort Monmout h, NJ 07703 ATTN: AMSEL-TDD , Mr. T. A. Pfe i ffe r , Technical Dir. Di rector, El ectroni c Technology and Devices Lab, f or t

  12. Learning Analytics for 21st Century Competencies

    Science.gov (United States)

    Buckingham Shum, Simon; Crick, Ruth Deakin

    2016-01-01

    Many educational institutions are shifting their teaching and learning towards equipping students with knowledge, skills, and dispositions that prepare them for lifelong learning, in a complex and uncertain world. These have been termed "21st century competencies." Learning analytics (LA) approaches in general offer different kinds of…

  13. St. Emmanuel, Simon-Peter Ayooluwa

    African Journals Online (AJOL)

    St. Emmanuel, Simon-Peter Ayooluwa. Vol 6 (2015) - Articles Xenophobia: A crime against humanity and its attendant implications on human rights. Abstract PDF. ISSN: 2276-7371. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

  14. 51 ST. AUGUSTINE VERSUS NIGERIA ON CORPORATE ...

    African Journals Online (AJOL)

    Tracie1

    Angwe Ken Agede:St. Augusrine Versus Nigeria on Corporate Corruption and impunity… 53 ... and South. Korea are making frantic efforts to curЛ this trend. It ... interest in philosophy and re-oriented his values. In a draft of a correspondence of 371 to his mother. Augustine shares his discovery and contemplates course.

  15. Ambulant ST-segmentmonitorering efter akut myokardieinfarkt

    DEFF Research Database (Denmark)

    Mickley, H; Junker, A; Friis, E V

    1994-01-01

    Over the last decade the concept of silent myocardial ischaemia has received considerable attention. Without doubt, the increased use of ambulatory ST-segment monitoring is the most important reason for the growing interest in this field. The prevalence of ambulatory ischaemia after myocardial in...

  16. Eesti goes St. Etienne / Anna Roomet

    Index Scriptorium Estoniae

    Roomet, Anna

    2006-01-01

    Näitus Eesti Kunstiakadeemia tootedisaini osakonna magistrantide viimase kahe aasta projektide paremikust esindas Eestit disainibiennaalil St. Etiennis Prantsusmaal. Näituse panid üles Pent Talvet ja Pavel Sidorenko, näitusel osalejad: Anna-Maria Einla, Kätlin Kangur, Triin Kuusler, Andri Laidre, Veiko Liis, Liina-Kai Raivet, P. Sidorenko, P. Talvet, Ingela Viks, Triin Voss

  17. 78 FR 44927 - 101st Commission Meeting

    Science.gov (United States)

    2013-07-25

    ... From the Federal Register Online via the Government Publishing Office ARCTIC RESEARCH COMMISSION 101st Commission Meeting Notice is hereby given that the U.S. Arctic Research Commission will hold its... language interpreters, must inform the Commission of those needs in advance of the meeting. Contact person...

  18. Morphing into a 21st Century Trainer.

    Science.gov (United States)

    Mager, R. F.

    1996-01-01

    Forces that will affect trainers into the next century include rapid change, information overload, globalization, downsizing, empowerment, and remote worksites. Key characteristics of a 21st-century trainer include performance orientation, technical skills, social skills, self-employability, bilingualism, and international competence. (JOW)

  19. [Military doctors and Community of St. Eugene].

    Science.gov (United States)

    Poddubnyĭ, M V

    2012-01-01

    Article focuses on the role of military physicians in the establishment and operation of the Community of St. Eugene in St. Petersburg (1882-1918). Since 1900 the hospital functioned as a community of 3 pavilions, which had 84 regular beds, including 15 free. At various times in outpatient clinics and courses of the Community of St. Eugene worked different professors of Military-medical Academy: ophthalmologist Bellyarminov L.G., physician Manassein V.A., medicolegist Kosorotov D.P. and assistant professors Danillo S.N. and Popov. In the implementation of a "medical project" Community of St. Eugene exceptional role belonged to MD Aleksey Belyaev, a staff member of the Main Military Medical Administration, also chairing the editorial board "Military-medical journal". Role of community in care for the wounded during the Russian-Japanese war and World Wars is significant. Russian Community of fame has been associated with the outbreak in 1898, long-term activities for the production of art publications.

  20. Towards a 21st century ready curriculum

    NARCIS (Netherlands)

    Vloon, N.G.J.; Hammer, M.H.M.; Brahimi, N.

    2015-01-01

    Entrepreneurship and entrepreneurship education is generally viewed upon as being important for economic growth in the 21st century. Teaching entrepreneurship however seems to need another approach than regular education to fulfill the professional and ever changing needs. In this perspective active

  1. Life Parallels Art at St. Bonaventure

    Science.gov (United States)

    Lewis, Lionel S.

    2002-01-01

    In this article, the author chronicles the summary firing of Joseph Greer, a veteran sociology professor, over allegations of racism that evoke comparison to a Philip Roth novel about political correctness run amuck. Unlike the fictional story, the faculty at St. Bonaventure University did not seem to have much of an appetite for censuring…

  2. Bathymetry (2011) for Fish Bay, St. John

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution depth surface for Fish Bay, St. John in the U.S. Virgin Islands (USVI). The...

  3. Bathymetry (2011) for Coral Bay, St. John

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution depth surface for Coral Bay, St. John in the U.S. Virgin Islands (USVI). The...

  4. Psychological Science in the 21st Century

    Science.gov (United States)

    Cacioppo, John T.

    2013-01-01

    Science is constantly changing. If one hopes to keep pace with advances in science, one cannot simply repeat what one has done in the past, whether deciding how to invest limited research funds, searching to replace a retiring colleague, or teaching introductory psychology. Psychological science in the 21st century is more central and integrated…

  5. St. Luke's Medical Center: technologizing health care

    International Nuclear Information System (INIS)

    Tumanguil, S.S.

    1994-01-01

    The computerization of the St. Luke's Medical Center improved the hospital administration and management, particularly in nuclear medicine department. The use of computer-aided X-ray simulator machine and computerized linear accelerator machine in diagnosing and treating cancer are the most recent medical technological breakthroughs that benefited thousands of Filipino cancer patients. 4 photos

  6. St Vincent Youth and Careers in Agriculture

    Science.gov (United States)

    Webster, Nicole; Ganpat, Wayne

    2014-01-01

    Purpose: Given the ageing farming population in the Caribbean and the importance of agriculture to economy, there is cause for concern about the future of farming. This study seeks to explore the extent to which students pursuing agriculture in secondary schools in St Vincent and the Grenadines (SVG) were likely to engage in farming as well as…

  7. Material Connections: Steuart Building, St. Albans School.

    Science.gov (United States)

    Stephens, Suzanne

    1980-01-01

    The addition to the St. Albans campus in Washington, D.C., relates both to the style and the siting of the older "collegiate gothic" school nearby. The mixed-use building contains five classrooms, art and music spaces, and a student lounge. (Author/MLF)

  8. The 21st Century Information Environment.

    Science.gov (United States)

    Badger, Rod

    This paper on the 21st century information environment begins with a section that discusses the impact of e-commerce over the next ten years. The second section addresses government focus areas, including ensuring a telecommunications infrastructure, developing the IT (information technology) industry, promoting innovation and entrepreneurship,…

  9. « ImpersoNations » : cinéma national, imaginaires historiques et nouveau cinéma européen

    OpenAIRE

    Elsaesser, Thomas

    2014-01-01

    La question du capital culturel propre à la diversité linguistique de l’Europe reste entière. Quels sont les avantages et les inconvénients de cet éventail de langues dans le cinéma ? Les films, quand ils franchissent les frontières, sont souvent doublés. Or, comme un bon jeu d’acteur représente une symbiose très particulière entre le corps, la gestuelle, la voix et l’intonation, les amateurs de cinéma ne peuvent se passer des films tournés dans leur propre langue. A l’instar du son, qui revê...

  10. M&A Performance and Economic Impact: Integration and Critical Assessment of Methodological Approach

    Directory of Open Access Journals (Sweden)

    Karolis Andriuskevicius

    2017-11-01

    Full Text Available Purpose of the article: Existing methodologies employed within the M&A performance framework are investigated and critically discuss. Methodology/methods: The research has been carried out as a structured assessment of past literature. The findings from scientific articles and studies by various scholars have been categorized, grouped and summarized to discern a meta-analytic view of the work carried out to date. Scientific aim: The conducted research seeks to ascertain and evaluate theoretically existing methodologies used in empirical studies that would allow proper and critical understanding of the results of various findings in the holistic and global M&As area. Findings: The research elaborates on several key developments in M&A methodology and performance studies carried out in empirical works during the last two decades. The findings help to independently and objectively assess performance of M&A from a holistic perspective. Conclusions: Each methodology measuring either M&A performance on a corporate level or effects of M&A on the economy level shall be interpreted and relied on with caution as each of them dispose their limitations whereas application of these methodologies is subject to data availability and case specific.

  11. y comercialización de maíz de Sinaloa

    Directory of Open Access Journals (Sweden)

    José Alberto García Salazar

    2006-01-01

    Full Text Available La política comercial instrumentada por el Gobierno de México dirigida al mercado de maíz se ha caracterizado por la autorización de importaciones libres de arancel superiores a la cuota establecida en el Tratado de Libre Comercio de América del Norte. Con el objetivo de analizar cómo esta política podría afectar la comercialización de la producción de maíz de Sinaloa, se usó un modelo de distribución de la producción del grano que incorpora características espaciales e intertemporales. Los resultados indican que si el consumo nacional real de maíz fuera menor en 10%, respecto al consumo nacional aparente, las mayores importaciones determinarían que 954 mil toneladas de la producción de la entidad no pudrían comercializarse. Debido a que esta situación resta competitividad al productor de maíz, puesto que la producción no comercializada tiene que almacenarse, los productores sinaloenses deberán estar pendientes y vigilar las decisiones del Gobierno en materia de cupos de importación de maíz.

  12. NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function.

    Science.gov (United States)

    Kotak, Sachin; Busso, Coralie; Gönczy, Pierre

    2013-09-11

    Spindle positioning and spindle elongation are critical for proper cell division. In human cells, an evolutionary conserved ternary complex (NuMA/LGN/Gαi) anchors dynein at the cortex during metaphase, thus ensuring correct spindle positioning. Whether this complex contributes to anaphase spindle elongation is not known. More generally, the mechanisms coupling mitotic progression with spindle behaviour remain elusive. Here, we uncover that levels of cortical dynein markedly increase during anaphase in a NuMA-dependent manner. We demonstrate that during metaphase, CDK1-mediated phosphorylation at T2055 negatively regulates NuMA cortical localization and that this phosphorylation is counteracted by PPP2CA phosphatase activity. We establish that this tug of war is essential for proper levels of cortical dynein and thus spindle positioning during metaphase. Moreover, we find that upon CDK1 inactivation in anaphase, the rise in dephosphorylated NuMA at the cell cortex leads to cortical dynein enrichment, and thus to robust spindle elongation. Our findings uncover a mechanism whereby the status of NuMA phosphorylation coordinates mitotic progression with proper spindle function.

  13. NuMA distribution and microtubule configuration in rabbit oocytes and cloned embryos.

    Science.gov (United States)

    Yan, Li-Ying; Huang, Jun-Cheng; Zhu, Zi-Yu; Lei, Zi-Li; Shi, Li-Hong; Nan, Chang-Long; Zhao, Zhen-Jun; Ouyang, Ying-Chun; Song, Xiang-Fen; Sun, Qing-Yuan; Chen, Da-Yuan

    2006-12-01

    The assembly of microtubules and the distribution of NuMA were analyzed in rabbit oocytes and early cloned embryos. Alpha-tubulin was localized around the periphery of the germinal vesicle (GV). After germinal vesicle breakdown (GVBD), multi-arrayed microtubules were found tightly associated with the condensed chromosomes and assembled into spindles. After the enucleated oocyte was fused with a fibroblast, microtubules were observed around the introduced nucleus in most reconstructed embryos and formed a transient spindle 2-4 h post-fusion (hpf). A mass of microtubules surrounded the swollen pseudo-pronucleus 5 hpf and a normal spindle was formed 13 hpf in cloned embryos. NuMAwas detected in the nucleus in germinal vesicle-stage oocytes, and it was concentrated at the spindle poles in both meiotic and mitotic metaphase. In both donor cell nucleus and enucleated oocyte cytoplasm, NuMA was not detected, while NuMA reappeared in pseudo-pronucleus as reconstructed embryo development proceeded. However, no evident NuMA staining was observed in the poles of transient spindle and first mitotic spindle in nuclear transfer eggs. These results indicate that NuMA localization and its spindle pole tethering function are different during rabbit oocyte meiosis and cloned embryo mitosis.

  14. DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo.

    Science.gov (United States)

    Zubradt, Meghan; Gupta, Paromita; Persad, Sitara; Lambowitz, Alan M; Weissman, Jonathan S; Rouskin, Silvi

    2017-01-01

    Coupling of structure-specific in vivo chemical modification to next-generation sequencing is transforming RNA secondary structure studies in living cells. The dominant strategy for detecting in vivo chemical modifications uses reverse transcriptase truncation products, which introduce biases and necessitate population-average assessments of RNA structure. Here we present dimethyl sulfate (DMS) mutational profiling with sequencing (DMS-MaPseq), which encodes DMS modifications as mismatches using a thermostable group II intron reverse transcriptase. DMS-MaPseq yields a high signal-to-noise ratio, can report multiple structural features per molecule, and allows both genome-wide studies and focused in vivo investigations of even low-abundance RNAs. We apply DMS-MaPseq for the first analysis of RNA structure within an animal tissue and to identify a functional structure involved in noncanonical translation initiation. Additionally, we use DMS-MaPseq to compare the in vivo structure of pre-mRNAs with their mature isoforms. These applications illustrate DMS-MaPseq's capacity to dramatically expand in vivo analysis of RNA structure.

  15. Study of MA Effect on Yield Strength and Ductility of X80 Linepipe Steels Weld

    Science.gov (United States)

    Huda, Nazmul; Lazor, Robert; Gerlich, Adrian P.

    2017-09-01

    Multipass GMAW (Gas Metal Arc Welding) welding was used to join X80 linepipe materials using two weld metals of slightly different compositions. Welding wires with diameters of 0.984 and 0.909 mm were used while applying the same heat input in each pass. The slight difference in the wire diameters resulted in different HAZ microstructures. The microstructures in the doubly reheated HAZ of both welds were found to contain bainite-ferrite. However, etching also revealed a difference in martensite-austenite (MA) fraction in these reheated zones. The MA exhibited twice the hardness of ferrite when measured by nanoindentation. Tensile testing from the reheated zone of both welds revealed a difference in yield strength, tensile strength and elongation of the transverse weld specimens. In the reheated zone of weld A, (produced with a 0.984 mm wire) a higher fraction of MA was observed, which resulted in higher strength but lower elongation compared to weld B. The ductility of weld A was found severely impaired (to nearly half of weld B) due to formation of closely spaced voids around the MA, along with debonding of MA from the matrix, which occurs just above the yield stress.

  16. Stáří mladýma očima: zdroje nevraživosti mladých k seniorům

    Directory of Open Access Journals (Sweden)

    Romana Trusínová

    2013-04-01

    Full Text Available As we live in an ageing society, intergenerational cohesion represents an increasingly important theme. Sociological research has however shown that this cohesion is sometimes undermined by conflict or lack of respect between members of different generations. This is why this study aims to explore the mindset which fuels young adults’ expression of ageist attitudes toward seniors. The main questions are: What triggers hostile feelings in some young adults toward the elderly and what can lead young people to vent these feelings? A qualitative sociological research was used to answer these questions. Indepth interviews were attended by adult residents of the Czech Republic, aged 19-28. The research confirmed the findings of earlier social researchers; namely, that prejudice against the elderly is not only shared, but also commonly expressed. This indicates that the fight against age-inequality is currently in its early days. The research further revealed that the most likely explanation for young people’s ageist behaviour is their disrespect towards seniors. The reasons for this disrespect seem to be particularly: contempt for ageing as a process of decline, disapproval of Czech senior citizens’ passive lifestyles and the imitation of behavioral patterns where rude communication with older family members is the norm. The research concluded that the ageist behaviour of young adults towards seniors is not a consequence of any specific intergenerational conflict. More likely, young people view seniors as an easy target for venting their frustrations. As the article draws to a close, the author discusses the possibilities of dealing with these problems with the objective of reinforcing intergenerational cohesion in the Czech Republic.

  17. Fort St. Vrain operations and future

    International Nuclear Information System (INIS)

    Brey, H.L.

    1991-01-01

    June 1989 resulted in the highest electric generation month in the history of the Fort St. Vrain plant. This culminated an excellent operating period involving the first half of 1988. The plant was then shutdown in July on a scheduled outage to make repairs in the main steam drive section of all of the helium circulators. This outage was significantly extended due to problems with moisture ingress into the primary coolant felt to be primarily from the core support floor section of the liner cooling system. 1989 also marks the 10th Anniversary of Fort St. Vrain as a commercial nuclear power plant. Electrical generation from this plant throughout this period has not been good, generally because of the prototypical nature of key plant components, primarily the helium circulators. Also, throughout this period there has been substantial increase in operations, maintenance, and fuel costs which could not be offset by the sale of electricity from the plant. This led to the decision to shutdown Fort St. Vrain permanently on or before June 30, 1990. The lessons learned and operational experiences from Fort St. Vrain have been substantial for the development of the Gas-Cooled Reactor Program and in achieving a safe, commercially viable plant design for the MHTGR. Superb fuel performance has not only provided a radiologically clean plant, but has achieved significant safety attributes in the licensing of the MHTGR. Equipment performance for Fort St. Vrain on key components and systems such as the steam generators, purification system control rod drives, and many others has been factored into the design of the MHTGR. Additional benefits are anticipated as the plant completes its operating phase and goes through defueling and decommissioning. As primary system components become available and are physically evaluated, further valuable data will be secured for the benefit of the MHTGR. (author)

  18. Spontaneous atopic dermatitis-like symptoms in a/a ma ft/ma ft/J flaky tail mice appear early after birth.

    Directory of Open Access Journals (Sweden)

    Magdalini Kypriotou

    Full Text Available Loss-of-function mutations in human profilaggrin gene have been identified as the cause of ichthyosis vulgaris (IV, and as a major predisposition factor for atopic dermatitis (AD. Similarly, flaky tail (a/a ma ft/ma ft/J mice were described as a model for IV, and shown to be predisposed to eczema. The aim of this study was to correlate the flaky tail mouse phenotype with human IV and AD, in order to dissect early molecular events leading to atopic dermatitis in mice and men, suffering from filaggrin deficiency. Thus, 5-days old flaky tail pups were analyzed histologically, expression of cytokines was measured in skin and signaling pathways were investigated by protein analysis. Human biopsies of IV and AD patients were analyzed histologically and by real time PCR assays. Our data show acanthosis and hyperproliferation in flaky tail epidermis, associated with increased IL1β and thymic stromal lymphopoietin (TSLP expression, and Th2-polarization. Consequently, NFκB and Stat pathways were activated, and IL6 mRNA levels were increased. Further, quantitative analysis of late epidermal differentiation markers revealed increased Small proline-rich protein 2A (Sprr2a synthesis. Th2-polarization and Sprr2a increase may result from high TSLP expression, as shown after analysis of 5-days old K14-TSLP tg mouse skin biopsies. Our findings in the flaky tail mouse correlate with data obtained from patient biopsies of AD, but not IV. We propose that proinflammatory cytokines are responsible for acanthosis in flaky tail epidermis, and together with the Th2-derived cytokines lead to morphological changes. Accordingly, the a/a ma ft/ma ft/J mouse model can be used as an appropriate model to study early AD onset associated with profilaggrin deficiency.

  19. From 21st century skills to 21st century human being

    DEFF Research Database (Denmark)

    Hjøllund, Niels-Peder Osmundsen; Jørgensen, Tobias Heiberg

    2017-01-01

    CLD and we must take the next step, where we stop thinking about skills and competencies and start thinking and acting on the fundamental existential implication of the 21st century. What we need now is not more 21st century skills, but 21st century human beings....... of the presentation will be the ideas and experiences of ‘Future Classroom Lab’, which is a ground-breaking initiative promoting new ways of handling the education of the teachers and pedagogues of tomorrow. Media and technologies are inevitable conditions in our everyday life in 2017 and therefore...... they are conditions that need to be addressed in the training of teachers and pedagogues. Professional understanding and application of technologies and media are thus a key element in the basic professional competences of the teachers and pedagogues of tomorrow. We are all now well underway in our thinking of 21st...

  20. LiDAR Relative Reflectivity Surface (2011) for the St. Thomas East End Reserve, St. Thomas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution relative seafloor reflectivity surface for the St. Thomas East End Reserve...

  1. The Nuclear Mitotic Apparatus (NuMA) protein is contributed by the donor cell nucleus in cloned porcine embryos.

    Science.gov (United States)

    Liu, Zhonghua; Schatten, Heide; Hao, Yanhong; Lai, Liangxue; Wax, David; Samuel, Melissa; Zhong, Zhi-Sheng; Sun, Qing-Yuan; Prather, Randall S

    2006-05-01

    The Nuclear Mitotic Apparatus (NuMA) protein is a multifunctional protein that is localized to the nucleus in interphase and to the poles of the mitotic apparatus during mitosis. In unfertilized porcine oocytes, NuMA is localized to the meiotic spindle. NuMA is removed along with the meiotic spindle during the enucleation process before reconstructing the egg by introducing the donor cell nucleus to produce cloned embryos. Questions have been raised regarding the source for NuMA in cloned embryos, as the enucleated oocyte does not contain detectable NuMA in the cytoplasm. To determine the source of NuMA in porcine nuclear transfer (NT) embryos, we conducted an immunofluorescence microscopy study with antibodies against NuMA to investigate the appearance and distribution of NuMA before and after reconstructing NT embryos with porcine skin fibroblasts. We used donor cells from a confluent culture with all cells in interphase. For comparative studies, we also determined the immunofluorescence pattern of NuMA, gamma-tubulin, and alpha-tubulin in porcine fibroblasts, parthenogenetic embryos and in vitro fertilized (IVF) embryos. Results show that NuMA was localized in nuclei of 33.5% (163/456) of the serum-deprived fibroblasts used as donor cells. No NuMA staining was detected in enucleated pig oocytes. Immediately after nuclear transfer, NuMA staining was absent in all donor cell fibroblast nuclei (0 h) but staining was detected by 6 h within the reconstructed eggs, at which time the transferred somatic cell nucleus swelled in most cells (19/27) and became a pronucleus-like structure. NuMA was localized exclusively within the pronucleus-like structures (15/27). At 25 h, NuMA was detected inside the nucleus (16/25) either in one-cell or in 2-cell stage embryos. Interestingly, in parthenogenetic embryos, NuMA staining was not detected in all 42 eggs examined at 1 h, and evident NuMA staining was only detected inside a few (4/51 at 6 h; 6/48 at 25 h) of the nuclei. In IVF

  2. The Banana Transcriptional Repressor MaDEAR1 Negatively Regulates Cell Wall-Modifying Genes Involved in Fruit Ripening.

    Science.gov (United States)

    Fan, Zhong-Qi; Kuang, Jian-Fei; Fu, Chang-Chun; Shan, Wei; Han, Yan-Chao; Xiao, Yun-Yi; Ye, Yu-Jie; Lu, Wang-Jin; Lakshmanan, Prakash; Duan, Xue-Wu; Chen, Jian-Ye

    2016-01-01

    Ethylene plays an essential role in many biological processes including fruit ripening via modulation of ethylene signaling pathway. Ethylene Response Factors (ERFs) are key transcription factors (TFs) involved in ethylene perception and are divided into AP2, RAV, ERF, and DREB sub-families. Although a number of studies have implicated the involvement of DREB sub-family genes in stress responses, little is known about their roles in fruit ripening. In this study, we identified a DREB TF with a EAR motif, designated as MaDEAR1, which is a nucleus-localized transcriptional repressor. Expression analysis indicated that MaDEAR1 expression was repressed by ethylene, with reduced levels of histone H3 and H4 acetylation at its regulatory regions during fruit ripening. In addition, MaDEAR1 promoter activity was also suppressed in response to ethylene treatment. More importantly, MaDEAR1 directly binds to the DRE/CRT motifs in promoters of several cell wall-modifying genes including MaEXP1/3, MaPG1, MaXTH10, MaPL3, and MaPME3 associated with fruit softening during ripening and represses their activities. These data suggest that MaDEAR1 acts as a transcriptional repressor of cell wall-modifying genes, and may be negatively involved in ethylene-mediated ripening of banana fruit. Our findings provide new insights into the involvement of DREB TFs in the regulation of fruit ripening.

  3. The banana transcriptional repressor MaDEAR1 negatively regulates cell wall-modifying genes involved in fruit ripening

    Directory of Open Access Journals (Sweden)

    Zhong-qi Fan

    2016-07-01

    Full Text Available Ethylene plays an essential role in many biological processes including fruit ripening via modulation of ethylene signaling pathway. Ethylene Response Factors (ERFs are key transcription factors (TFs involved in ethylene perception and are divided into AP2, RAV, ERF and DREB sub-families. Although a number of studies have implicated the involvement of DREB sub-family genes in stress responses, little is known about their roles in fruit ripening. In this study, we identified a DREB TF with a EAR motif, designated as MaDEAR1, which is a nucleus-localized transcriptional repressor. Expression analysis indicated that MaDEAR1 expression was repressed by ethylene, with reduced levels of histone H3 and H4 acetylation at its regulatory regions during fruit ripening. In addition, MaDEAR1 promoter activity was also suppressed in response to ethylene treatment. More importantly, MaDEAR1 directly binds to the DRE/CRT motifs in promoters of several cell wall-modifying genes including MaEXP1/3, MaPG1, MaXTH10, MaPL3 and MaPME3 associated with fruit softening during ripening and represses their activities. These data suggest that MaDEAR1 acts as a transcriptional repressor of cell wall-modifying genes, and may be negatively involved in ethylene-mediated ripening of banana fruit. Our findings provide new insights into the involvement of DREB TFs in the regulation of fruit ripening.

  4. CDC WONDER: Population - Bridged-Race July 1st Estimates

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Population - Bridged-Race July 1st Estimates online databases report bridged-race population estimates of the July 1st resident population of the United States,...

  5. Dying hard industrial carnage in st lawrence, newfoundland

    CERN Document Server

    Leyton, Elliott

    2004-01-01

    Dying Hard: Industrial Carnage in St. Lawrence, Newfoundland is a series of first-hand accounts by miners suffering from industrial diseases contracted while working in the fluorspar mines of St. Lawrence, Newfoundland.

  6. Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis

    Science.gov (United States)

    Dautzenberg, M J D; Haverkate, M R; Bonten, M J M; Bootsma, M C J

    2016-01-01

    Objectives Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient populations. Hyperendemicity could result from increased transmissibility, longer duration of infectiousness, and/or higher pathogenic potential as compared with other lineages of the same species. The aim of our research is to quantitatively estimate these critical parameters for E. coli ST131 and K. pneumoniae ST258, in order to investigate whether E. coli ST131 and K. pneumoniae ST258 are truly hyperendemic clones. Primary outcome measures A systematic literature search was performed to assess the evidence of transmissibility, duration of infectiousness, and pathogenicity for E. coli ST131 and K. pneumoniae ST258. Meta-regression was performed to quantify these characteristics. Results The systematic literature search yielded 639 articles, of which 19 data sources provided information on transmissibility (E. coli ST131 n=9; K. pneumoniae ST258 n=10)), 2 on duration of infectiousness (E. coli ST131 n=2), and 324 on pathogenicity (E. coli ST131 n=285; K. pneumoniae ST258 n=39). Available data on duration of carriage and on transmissibility were insufficient for quantitative assessment. In multivariable meta-regression E. coli isolates causing infection were associated with ST131, compared to isolates only causing colonisation, suggesting that E. coli ST131 can be considered more pathogenic than non-ST131 isolates. Date of isolation, location and resistance mechanism also influenced the prevalence of ST131. E. coli ST131 was 3.2 (95% CI 2.0 to 5.0) times more pathogenic than non-ST131. For K. pneumoniae ST258 there were not enough data for meta-regression assessing the influence of colonisation versus infection on ST258 prevalence. Conclusions With the currently available data

  7. Development and tests of fast 1-MA linear transformer driver stages

    Directory of Open Access Journals (Sweden)

    A. A. Kim

    2009-05-01

    Full Text Available In this article we present the design and test results of the most powerful, fast linear transformer driver (LTD stage developed to date. This 1-MA LTD stage consists of 40 parallel RLC (resistor R, inductor L, and capacitor C circuits called “bricks” that are triggered simultaneously; it is able to deliver ∼1  MA current pulse with a rise time of ∼100  ns into the ∼0.1-Ohm matched load. The electrical behavior of the stage can be predicted by using a simple RLC circuit, thus simplifying the designing of various LTD-based accelerators. Five 1-MA LTD stages assembled in series into a module have been successfully tested with both resistive and vacuum electron-beam diode loads.

  8. MaRRS: A Software System for Generating Multimedia Radiology Reports using Adobe Acrobat

    Directory of Open Access Journals (Sweden)

    Kristy Moniz

    2010-06-01

    Full Text Available Despite the proliferation of mature multimedia software technologies, radiology reports continue to lack image content and structure that would improve the ability of referring clinicians to fully interpret and analyze radiological findings. This paper introduces an intuitive and interactive radiology report authoring system that provides enhanced visual multimedia capabilities, structured content, and reduced report production time, using a well-known PDF program, Adobe Acrobat. The system, which we call the Multimedia Radiology Report System, or MaRRS, allows radiologists to quickly and simply create and deliver effective interactive multimedia medical reports. This paper will introduce MaRRS, outline some related radiology report systems, and describe the unique structure and functionality of MaRRS in order to demonstrate its advantages for both radiologists and referring clinicians.

  9. Precio del maíz en México y ley del precio único

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Martínez Damián

    2017-01-01

    Full Text Available El abasto de maíz debe cubrirse con importaciones de Estados Unidos de América ( ee. uu. . Si dicho intercambio es de libre comercio, entonces debe observarse la ley del precio único ( lpu . Bajo un modelo vectorial de corrección de error, se examina la lpu para el precio de maíz en México y ee. uu . Los resultados si bien rechazan estadísticamente la lpu , el vector cointegrante estimado es de signo y magnitud acorde con la lpu , dicho vector implica la existencia de una combinación lineal estacionaria que provee evidencia de integración de mercados. Secundariamente se encuentra que el precio de maíz en México es causado, en el sentido de Granger, por el precio en ee. uu. y que dicho precio no es exógeno al vector examinado.

  10. Kuznetsov-Ma waves train generation in a left-handed material

    Science.gov (United States)

    Atangana, Jacques; Giscard Onana Essama, Bedel; Biya-Motto, Frederick; Mokhtari, Bouchra; Cherkaoui Eddeqaqi, Noureddine; Crépin Kofane, Timoléon

    2015-03-01

    We analyze the behavior of an electromagnetic wave which propagates in a left-handed material. Second-order dispersion and cubic-quintic nonlinearities are considered. This behavior of an electromagnetic wave is modeled by a nonlinear Schrödinger equation which is solved by collective coordinates theory in order to characterize the light pulse intensity profile. More so, a specific frequency range has been outlined where electromagnetic wave behavior will be investigated. The perfect combination of second-order dispersion and cubic nonlinearity leads to a robust soliton. When the quintic nonlinearity comes into play, it provokes strong and long internal perturbations which lead to Benjamin-Feir instability. This phenomenon, also called modulational instability, induces appearance of a Kuznetsov-Ma waves train. We numerically verify the validity of Kuznetsov-Ma theory by presenting physical conditions which lead to Kuznetsov-Ma waves train generation. Thereafter, some properties of such waves train are also verified.

  11. Kuznetsov-Ma Soliton Dynamics Based on the Mechanical Effect of Light.

    Science.gov (United States)

    Xiong, Hao; Gan, Jinghui; Wu, Ying

    2017-10-13

    A Kuznetsov-Ma soliton that exhibits an unusual pulsating dynamics has attracted particular attention in hydrodynamics and plasma physics in the context of understanding nonlinear coherent phenomena. Here, we demonstrate theoretically the formation of a novel form of Kuznetsov-Ma soliton in a microfabricated optomechanical array, where both photonic and phononic evolutionary dynamics exhibit periodic structure and coherent localized behavior enabled by radiation-pressure coupling of optical fields and mechanical oscillations, which is a manifestation of the unique property of optomechanical systems. Numerical calculations of the optomechanical dynamics show an excellent agreement with this theory. In addition to providing insight into optomechanical nonlinearity, optomechanical Kuznetsov-Ma soliton dynamics fundamentally broadens the regime of cavity optomechanics and may find applications in on-chip manipulation of light propagation.

  12. DaMaSCUS-CRUST: Dark Matter Simulation Code for Underground Scatterings - Crust Edition

    Science.gov (United States)

    Emken, Timon; Kouvaris, Chris

    2018-03-01

    DaMaSCUS-CRUST determines the critical cross-section for strongly interacting DM for various direct detection experiments systematically and precisely using Monte Carlo simulations of DM trajectories inside the Earth's crust, atmosphere, or any kind of shielding. Above a critical dark matter-nucleus scattering cross section, any terrestrial direct detection experiment loses sensitivity to dark matter, since the Earth crust, atmosphere, and potential shielding layers start to block off the dark matter particles. This critical cross section is commonly determined by describing the average energy loss of the dark matter particles analytically. However, this treatment overestimates the stopping power of the Earth crust; therefore, the obtained bounds should be considered as conservative. DaMaSCUS-CRUST is a modified version of DaMaSCUS (ascl:1706.003) that accounts for shielding effects and returns a precise exclusion band.

  13. Maíz: Alimento fundamental en las tradiciones y costumbres mexicanas

    Directory of Open Access Journals (Sweden)

    José de Jesús Cuevas Mejía

    2014-01-01

    Full Text Available El siguiente trabajo busca recalcar la importancia del maíz para el pueblo mexicano, que con el paso de los años ha logrado mantener su identidad no en vano por la fuerza y majestuosidad de sus tradiciones y costumbres. Es cierto que hoy en día es la base de la alimentación de muchas familias a lo largo del territorio de México, en cada hogar a la hora del almuerzo, la comida e incluso la merienda, el maíz está presente en una gran variedad de formas, texturas y colores. Esto nos hace pensar ¿Qué sería de las fiestas en México sin la presencia del maíz, que año con año se llevan a cabo por todo el territorio?

  14. Gas Kinematics In and Around Edge-on Galaxies from MaNGA Observations

    Science.gov (United States)

    Bizyaev, D.

    2016-06-01

    Mapping Nearby Galaxies at APO (MaNGA) is a massive Integral Field Unit survey of a large number of relatively nearby galaxies that started in 2014 as a part of SDSS-IV at the Apache Point Observatory. After the first year of observations MaNGA has obtained IFU spectra of about a thousand of objects, with several dozens of edge-on galaxies among them. The two-dimensional spectra help us constrain parameters of galactic components with superior rotation curves. There is a significant fraction of galaxies in which the extra-planar gas emission is confidently detected. The extra-planar gas velocity fields in several galaxies show signs of lagging rotation with respect to the gas motion close to the galactic plane. We show progress of MaNGA survey in observations of edge-on galaxies and discuss their impact on our understanding of gas kinematics in and around spiral galaxies after finishing the survey.

  15. Kuznetsov-Ma Soliton Dynamics Based on the Mechanical Effect of Light

    Science.gov (United States)

    Xiong, Hao; Gan, Jinghui; Wu, Ying

    2017-10-01

    A Kuznetsov-Ma soliton that exhibits an unusual pulsating dynamics has attracted particular attention in hydrodynamics and plasma physics in the context of understanding nonlinear coherent phenomena. Here, we demonstrate theoretically the formation of a novel form of Kuznetsov-Ma soliton in a microfabricated optomechanical array, where both photonic and phononic evolutionary dynamics exhibit periodic structure and coherent localized behavior enabled by radiation-pressure coupling of optical fields and mechanical oscillations, which is a manifestation of the unique property of optomechanical systems. Numerical calculations of the optomechanical dynamics show an excellent agreement with this theory. In addition to providing insight into optomechanical nonlinearity, optomechanical Kuznetsov-Ma soliton dynamics fundamentally broadens the regime of cavity optomechanics and may find applications in on-chip manipulation of light propagation.

  16. Microprobe monazite constraints for and early (ca. 790 Ma) Braziliano orogeny: The Embu Terrane, southeastern Brazil

    International Nuclear Information System (INIS)

    Vlach, Silvio R.F

    2001-01-01

    The evolution of the Mantiqueira Orogenetic System, Southeastern Brazil, comprises discrete episodes of tectonic collage and docking of remnants of Rodinia break-up in the borders of the Sao Francisco Craton. This system is related to the closure of the Adamastor ocean and assemblage of the western Gondwana super-continent during Neoproterozoic times (ca. 610-530 Ma, Brito Neves et al., 1999; Campos Neto, 2000). This report presents monazite microprobe dating results for metassediments from the Embu Complex, an important lithological unit from the Ribeira Belt, currently included in the Juiz de Fora terrane, a unit added to the Sao Francisco Craton at ca. 600-580 Ma. (Campos Neto, 2000). The age results unravel a main metamorphic episode and related orogeny at ca. 790 Ma and bring new insights concerning the agglutination of Gondwana in this region during the Neoproterozoic (au)

  17. Earth's youngest exposed granite and its tectonic implications: the 10-0.8 Ma Kurobegawa Granite.

    Science.gov (United States)

    Ito, Hisatoshi; Yamada, Ryuji; Tamura, Akihiro; Arai, Shoji; Horie, Kenji; Hokada, Tomokazu

    2013-01-01

    Although the quest for Earth's oldest rock is of great importance, identifying the youngest exposed pluton on Earth is also of interest. A pluton is a body of intrusive igneous rock that crystallized from slowly cooling magma at depths of several kilometers beneath the surface of the Earth. Therefore, the youngest exposed pluton represents the most recent tectonic uplift and highest exhumation. The youngest exposed pluton reported to date is the Takidani Granodiorite (~ 1.4 Ma) in the Hida Mountain Range of central Japan. Using LA-ICP-MS and SHRIMP U-Pb zircon dating methods, this study demonstrates that the Kurobegawa Granite, also situated in the Hida Mountain Range, is as young as ~ 0.8 Ma. In addition, data indicate multiple intrusion episodes in this pluton since 10 Ma with a ~ 2-million-year period of quiescence; hence, a future intrusion event is likely within 1 million years.

  18. Genre Analysis of MA Thesis Abstracts by native and (Iraqi non-native Speakers of English

    Directory of Open Access Journals (Sweden)

    Firas Abdul-Munim Jawad

    2017-12-01

    Full Text Available Abstract         The purpose of the present study is to investigate the macro-structure (move-step analysis of abstract section of MA theses in linguistics. There are two corpora consist of fifteen MA theses written by American native and fifteen others by Iraqi Arab non-native speakers of English. Based on the analysis, some similarities and differences were found regarding cyclicity (move structure and move-step frequency of occurrence. The findings of the present study are useful for Iraqi non-native writers by presenting the important factors that make them familiar with rhetorical move-step structure of MA thesis abstracts.

  19. CULTURAL DUE DILIGENCE IN M&A. IMPORTANCE OF SOFT RISKS FACTORS

    Directory of Open Access Journals (Sweden)

    Iulian Warter

    2017-06-01

    Full Text Available During the last decades, the corporate world has witnessed a significant rise in the number of cross border mergers and acquisitions (M&As. In cross border M&As, not only different corporate cultures collide, but also different professional and national cultures. The purpose of Cultural Due Diligence (CDD is to get a coherent image of the intercultural challenges of the M&A in order to be aware of the intercultural risks and opportunities. This article aims to reveal the perception of managers involved in the pre-M&A stage on the soft risks factors that need to be investigated during CDD. This study proposes an appraisal of the most important intercultural issues that need to be considered in M&A. Our contribution to the intercultural aspects of M&A literature consists in improving the current understanding of Cultural Due Diligence content.

  20. Earliest human occupations at Dmanisi (Georgian Caucasus) dated to 1.85-1.78 Ma.

    Science.gov (United States)

    Ferring, Reid; Oms, Oriol; Agustí, Jordi; Berna, Francesco; Nioradze, Medea; Shelia, Teona; Tappen, Martha; Vekua, Abesalom; Zhvania, David; Lordkipanidze, David

    2011-06-28

    The early Pleistocene colonization of temperate Eurasia by Homo erectus was not only a significant biogeographic event but also a major evolutionary threshold. Dmanisi's rich collection of hominin fossils, revealing a population that was small-brained with both primitive and derived skeletal traits, has been dated to the earliest Upper Matuyama chron (ca. 1.77 Ma). Here we present archaeological and geologic evidence that push back Dmanisi's first occupations to shortly after 1.85 Ma and document repeated use of the site over the last half of the Olduvai subchron, 1.85-1.78 Ma. These discoveries show that the southern Caucasus was occupied repeatedly before Dmanisi's hominin fossil assemblage accumulated, strengthening the probability that this was part of a core area for the colonization of Eurasia. The secure age for Dmanisi's first occupations reveals that Eurasia was probably occupied before Homo erectus appears in the East African fossil record.

  1. CULTURAL DUE DILIGENCE IN M&A. IMPORTANCE OF SOFT RISKS FACTORS

    Directory of Open Access Journals (Sweden)

    Iulian Walter

    2017-07-01

    Full Text Available During the last decades, the corporate world has witnessed a significant rise in the number of cross border mergers and acquisitions (M&As. In cross border M&As, not only different corporate cultures collide, but also different professional and national cultures. The purpose of Cultural Due Diligence (CDD is to get a coherent image of the intercultural challenges of the M&A in order to be aware of the intercultural risks and opportunities. This article aims to reveal the perception of managers involved in the pre-M&A stage on the soft risks factors that need to be investigated during CDD. This study proposes an appraisal of the most important intercultural issues that need to be considered in M&A. Our contribution to the intercultural aspects of M&A literature consists in improving the current understanding of Cultural Due Diligence content.

  2. MA TESOL Dissertations in a Changing Global Landscape: A Case from Iran

    Directory of Open Access Journals (Sweden)

    Parvaneh Tavakoli

    2018-01-01

    Full Text Available This paper has investigated the way the dissertation writing component of MA TESOL (Teaching English to Speakers of Other Languages programmes in Iran has changed over the past decade in relation to globalization. The data, collected from 40 questionnaires completed by Iranian academic staff teaching these programmes, suggest that while change in the content and curriculum has been minimal, some major shifts are observed in the functions MA dissertations serve. The most fundamental change reported is that dissertations are now seen in this local context as an opportunity to respond to the global trend of publish or perish. The analysis of the data demonstrates a complex picture of how global trends, national higher education policies and regulations and the local initiatives interact with one another to turn MA dissertations into a source of research publications.

  3. [Effects of Electroaupuncture Stimulation of "Xiajuxu" (ST 39), etc. on Duodenal Mucosal Injury, Serum Pro-inflammatory Factors Levels and Duodenal Nicotinic Acetylcholine Receptor alpha 7 Expression in Duodenal Ulcer Rats].

    Science.gov (United States)

    Ling, Xi; Zhang, Hong; Yi, Xi-qin; Wu, Jin-feng

    2016-04-01

    To observe the relatively specific effect of electroacupuncture (EA) of "Xiajuxu" (ST 39, the lower hesea paint of the small intestine), etc. on the level of serum TNF-alpha, lnterleukin-1 P (IL-1 P) and high mobility group protein B 1 (HMGB 1) contents, and duodenum a7 nicotinic acetyicholine receptor (nAchR) expression in duodenal ulcer rats, so as to explore its mechanisms underlying improving duodenal ulcer. Sixty SD rats were randomly divided into 6 groups: normal control, model, Xiajuxu (ST 39), Zusanli (ST 36), Shangjuxu (ST 37) and Yanglingquan (GB 34). The duodenal ulcer model was established by subcutaneous injection of 10% Cysteamine Hydrochloride (300 mg/kg), following by giving the rats with access to water containing Cysteamine. EA (10 Hz/50 Hz, 1- 3 mA) was applied to bilateral ST 39, ST 36, ST 37 and GB 34 for 30 min, once daily for 10 days. The ulcer scores (0-5 points) of the duodenal mucosa were assessed according to modified Moraes' methods. Serum TNF-alpha, IL-1 beta and HMGB 1 levels were assayed by ELISA and the expression of neuronal a7 nAchR in the duodenal tissue was detected by Western blot. After modeling, the ulcer score, serum TNF-alpha, IL-i p and HMGB 1 contents were significantly increased (P0.05). EA stimulation of ST 36, ST 37 and ST 39 can reduce ulcer injury in duodenal ulcer model rats, which may be associated with their effects in down-regulating serum TNF-alpha, IL-1 beta and HMGB 1 contents and up-regulating alpha7 nAchR expression of the duodenal tissue, possibly by suppressing immune and inflammatory reactions and regulating nicotinic activity.

  4. Ma_MISS on ExoMars: Mineralogical Characterization of the Martian Subsurface

    Science.gov (United States)

    De Sanctis, Maria Cristina; Altieri, Francesca; Ammannito, Eleonora; Biondi, David; De Angelis, Simone; Meini, Marco; Mondello, Giuseppe; Novi, Samuele; Paolinetti, Riccardo; Soldani, Massimo; Mugnuolo, Raffaele; Pirrotta, Simone; Vago, Jorge L.; Ma_MISS Team

    2017-07-01

    The Ma_MISS (Mars Multispectral Imager for Subsurface Studies) experiment is the visible and near infrared (VNIR) miniaturized spectrometer hosted by the drill system of the ExoMars 2020 rover. Ma_MISS will perform IR spectral reflectance investigations in the 0.4-2.2 μm range to characterize the mineralogy of excavated borehole walls at different depths (between 0 and 2 m). The spectral sampling is about 20 nm, whereas the spatial resolution over the target is 120 μm. Making use of the drill's movement, the instrument slit can scan a ring and build up hyperspectral images of a borehole. The main goal of the Ma_MISS instrument is to study the martian subsurface environment. Access to the martian subsurface is crucial to our ability to constrain the nature, timing, and duration of alteration and sedimentation processes on Mars, as well as habitability conditions. Subsurface deposits likely host and preserve H2O ice and hydrated materials that will contribute to our understanding of the H2O geochemical environment (both in the liquid and in the solid state) at the ExoMars 2020 landing site. The Ma_MISS spectral range and sampling capabilities have been carefully selected to allow the study of minerals and ices in situ before the collection of samples. Ma_MISS will be implemented to accomplish the following scientific objectives: (1) determine the composition of subsurface materials, (2) map the distribution of subsurface H2O and volatiles, (3) characterize important optical and physical properties of materials (e.g., grain size), and (4) produce a stratigraphic column that will inform with regard to subsurface geological processes. The Ma_MISS findings will help to refine essential criteria that will aid in our selection of the most interesting subsurface formations from which to collect samples.

  5. THE DATA REDUCTION PIPELINE FOR THE SDSS-IV MaNGA IFU GALAXY SURVEY

    International Nuclear Information System (INIS)

    Law, David R.; Cherinka, Brian; Yan, Renbin; Andrews, Brett H.; Bershady, Matthew A.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Bolton, Adam S.; Brownstein, Joel R.; Bundy, Kevin; Chen, Yanmei; Drory, Niv; D’Souza, Richard; Jones, Amy; Kauffmann, Guinevere; Fu, Hai

    2016-01-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622–10354 Å and an average footprint of ∼500 arcsec 2 per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ∼100 million raw-frame spectra and ∼10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ∼8500 Å and reach a typical 10 σ limiting continuum surface brightness μ  = 23.5 AB arcsec −2 in a five-arcsecond-diameter aperture in the g -band. The wavelength calibration of the MaNGA data is accurate to 5 km s −1 rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ  = 72 km s −1 .

  6. Dynamic changes in NuMA and microtubules in monkey-rabbit nuclear transfer embryos.

    Science.gov (United States)

    Yan, Li-Ying; Shi, Li-Hong; Sheng, Hui-Zhen; Liu, Shu-Zhen; Huang, Jun-Cheng; Zhu, Zi-Yu; OuYang, Ying-Chun; Lei, Zi-Li; Song, Xiang-Fen; Sun, Qing-Yuan; Chen, Da-Yuan

    2006-05-01

    Previous reports have indicated that failure in cloning monkey is attributed to the removal of nuclear mitotic apparatus (NuMA) during enucleation and subsequent abnormal organization of mitotic apparatus. This study investigated the transformation and assembly of tubulin and NuMA protein during the first cell cycle of cloned monkey embryos reconstructed by using enucleated rabbit oocytes as recipients. After the oocyte fused with a fibroblast, extensive microtubule organization was observed around the introduced nucleus in most reconstructed embryos, suggesting the introduction of a somatic cell centrosome. A high proportion of fibroblast nuclei transferred into non-activated oocytes underwent premature chromosome condensation (PCC), transient spindle organization and chromosomes separation, followed by the formation of two pronucleus-like structures. In contrast, fibroblast nuclei in pre-activated ooplasm rarely underwent PCC, but formed a swollen pronucleus-like structure. Normal spindles were observed in about one third of the cloned embryos reconstructed by both methods. After transferring monkey fibroblasts into NuMA-removed enucleated rabbit oocytes, NuMA was localized in pseudo-pronuclei and gradually moved to mitotic spindle poles at the first mitotic spindle poles. NuMA antibody microinjection resulted in spindle disorganization and chromosome misalignment, but did not significantly affect early cleavage. Our findings indicate that: 1. NuMA in donor monkey fibroblast may contribute to form a normal spindle in enucleated rabbit oocyte; 2. when non-activated cytoplasts and pre-activated cytoplasts are used as recipients, the donor nuclei undergo different morphological changes, but yield similar early embryo development; 3. although abnormal spindle organization and chromosome alignment may cause low efficiency of animal cloning, these abnormalities do not significantly affect early cleavage.

  7. Conceptual Framework: Development of Interactive Reading Malay Language Learning System (I-ReaMaLLS

    Directory of Open Access Journals (Sweden)

    Ismail Nurulisma

    2018-01-01

    Full Text Available Reading is very important to access knowledge. Reading skills starts during preschool level no matter of the types of languages. At present, there are many preschool children who are still unable to recognize letters or even words. This leads to the difficulties in reading. Therefore, there is a need of intervention in reading to overcome such problems. Thus, technologies were adapted in enhancing learning skills, especially in learning to read among the preschool children. Phonological is one of the factors to be considered to ensure a smooth of transition into reading. Phonological concept enables the first learner to easily learn reading such to learn reading Malay language. The medium of learning to read Malay language can be assisted via the supportive of multimedia technology to enhance the preschool children learning. Thus, an interactive system is proposed via a development of interactive reading Malay language learning system, which is called as I-ReaMaLLS. As a part of the development of I-ReaMaLLS, this paper focus on the development of conceptual framework in developing interactive reading Malay language learning system (I-ReaMaLLS. I-ReaMaLLS is voice based system that facilitates the preschool learner in learning reading Malay language. The conceptual framework of developing I-ReaMaLLS is conceptualized based on the initial study conducted via methods of literature review and observation with the preschool children, aged 5 – 6 years. As the result of the initial study, research objectives have been affirmed that finally contributes to the design of conceptual framework for the development of I-ReaMaLLS.

  8. THE DATA REDUCTION PIPELINE FOR THE SDSS-IV MaNGA IFU GALAXY SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Law, David R. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Cherinka, Brian [Center for Astrophysical Sciences, Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 (United States); Yan, Renbin [Department of Physics and Astronomy, University of Kentucky, 505 Rose Street, Lexington, KY 40506-0055 (United States); Andrews, Brett H. [Department of Physics and Astronomy and PITT PACC, University of Pittsburgh, 3941 O’Hara Street, Pittsburgh, PA 15260 (United States); Bershady, Matthew A. [Department of Astronomy, University of Wisconsin-Madison, 475 N. Charter Street, Madison, WI 53706 (United States); Bizyaev, Dmitry [Apache Point Observatory, P.O. Box 59, Sunspot, NM 88349 (United States); Blanc, Guillermo A. [Departamento de Astronomía, Universidad de Chile, Camino del Observatorio 1515, Las Condes, Santiago (Chile); Blanton, Michael R. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Bolton, Adam S.; Brownstein, Joel R. [Department of Physics and Astronomy, University of Utah, 115 S 1400 E, Salt Lake City, UT 84112 (United States); Bundy, Kevin [Kavli Institute for the Physics and Mathematics of the universe, Todai Institutes for Advanced Study, the University of Tokyo, Kashiwa, 277-8583 (Kavli IPMU, WPI) (Japan); Chen, Yanmei [School of Astronomy and Space Science, Nanjing University, Nanjing 210093 (China); Drory, Niv [McDonald Observatory, Department of Astronomy, University of Texas at Austin, 1 University Station, Austin, TX 78712-0259 (United States); D’Souza, Richard; Jones, Amy; Kauffmann, Guinevere [Max Planck Institute for Astrophysics, Karl-Schwarzschild-Str. 1, D-85748 Garching (Germany); Fu, Hai, E-mail: dlaw@stsci.edu [Department of Physics and Astronomy, University of Iowa, Iowa City, IA 52242 (United States); and others

    2016-10-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622–10354 Å and an average footprint of ∼500 arcsec{sup 2} per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ∼100 million raw-frame spectra and ∼10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ∼8500 Å and reach a typical 10 σ limiting continuum surface brightness μ  = 23.5 AB arcsec{sup −2} in a five-arcsecond-diameter aperture in the g -band. The wavelength calibration of the MaNGA data is accurate to 5 km s{sup −1} rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ  = 72 km s{sup −1}.

  9. The Data Reduction Pipeline for the SDSS-IV MaNGA IFU Galaxy Survey

    Science.gov (United States)

    Law, David R.; Cherinka, Brian; Yan, Renbin; Andrews, Brett H.; Bershady, Matthew A.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Bolton, Adam S.; Brownstein, Joel R.; Bundy, Kevin; Chen, Yanmei; Drory, Niv; D'Souza, Richard; Fu, Hai; Jones, Amy; Kauffmann, Guinevere; MacDonald, Nicholas; Masters, Karen L.; Newman, Jeffrey A.; Parejko, John K.; Sánchez-Gallego, José R.; Sánchez, Sebastian F.; Schlegel, David J.; Thomas, Daniel; Wake, David A.; Weijmans, Anne-Marie; Westfall, Kyle B.; Zhang, Kai

    2016-10-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622-10354 Å and an average footprint of ˜500 arcsec2 per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ˜100 million raw-frame spectra and ˜10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ˜8500 Å and reach a typical 10σ limiting continuum surface brightness μ = 23.5 AB arcsec-2 in a five-arcsecond-diameter aperture in the g-band. The wavelength calibration of the MaNGA data is accurate to 5 km s-1 rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ = 72 km s-1.

  10. St. Lukes' Survey on vaccination coverage | Quartero | Malawi ...

    African Journals Online (AJOL)

    St. Lukes hospital, a PRAM unit in Zomba district, had an estimated vaccination coverage of 44% in 1990. To conf"1rID this very low coverage, a survey was done in the 5 km catchment area around the hospital. 611 children, being 104% of the estimated number, bom between 1st June 1989 and 31st May 1990 were ...

  11. The cognitive status of stød

    DEFF Research Database (Denmark)

    Clausen, Sara Juul; Kristensen, Line Burholt

    2015-01-01

    The Danish prosodic phenomenon stød is associated with a specific range of suffixes including the singular definite suffixes -en and -et. Diachronically, as well as distributionally, stød is related to Swedish/Norwegian accent 1, but unlike accent 1, stød is seen as phonetically and phonologicall...

  12. evaluation agronomique des varietes de maïs riches en proteines

    African Journals Online (AJOL)

    Administrateur

    Cinq variétés de maïs riches en protéines de qualité (MRP) ont été expérimentées en station puis en milieu paysan, avec des témoins locaux en ..... sionnent bord champ. En ce qui concerne la ... Tableau 1 : Carrés moyens des variables étudiées en station, pour les variétés de maïs précoces riche en protéines (MRP).

  13. Effets de la culture permanente coton-maïs sur l'évolution d ...

    African Journals Online (AJOL)

    Effets de la culture permanente coton-maïs sur l'évolution d'indicateurs de fertilité des sols de l'Ouest du Burkina Faso. ... Le présent travail avait pour objectifs (i) de faire un diagnostic organo-minéral des sols, et (ii) de déterminer les impacts de la baisse de fertilité du sol sur les performances du maïs et des légumineuses.

  14. Non-economic determinants of structural transformations in Małopolska agriculture

    Directory of Open Access Journals (Sweden)

    Maciej Basaj

    2009-01-01

    Full Text Available In the article results of the research conducted in 2008 among farmers in two districts located in northern part of the Małopolska voivodeship have been presented. The aim of the article is the presentation of farmers’ opinions and attitudes against accomplishing structural alternations in their vicinity. Getting to know farmers’ intentions against the future of their farms, and also getting to know their estimations about the future of their farms in the vicinity can have particular significance in the prognosis and program of further development of rural areas – especially in such a region, with a big agrarian overpopulation as the Małopolska.

  15. Vietnam Inbound M&A Activity: The Role of Government Policy and Regulatory Environment

    Directory of Open Access Journals (Sweden)

    Jamshid C. Hosseini

    2017-05-01

    Full Text Available With a robust recent history of reform and opening, joining of the World Trade Organization, and negotiating a myriad of regional and global trade agreements, Vietnam has emerged as a promising destination for foreign direct investment(FDI and cross-border mergers and acquisitions (M&A. In this paper, we providean overview of Vietnam’s inbound mergers and acquisitions and review the twomain driving forces of inbound M&A, which are the legal framework reformprocess and the equitization of State-owned enterprises. We close by providingdirections for future research in the area of cross-border M&As.

  16. Reconstruction of Northeast Asian Deformation Integrated with Western Pacific Plate Subduction since 200 Ma

    Science.gov (United States)

    Liu, S.; Gurnis, M.; Ma, P.; Zhang, B.

    2017-12-01

    The configuration and kinematics of continental deformation and its marginal plate tectonics on the Earth's surface are intrinsic manifestations of plate-mantle coupling. The complex interactions of plate boundary forces result in plate motions that are dominated by slab pull and ridge push forces and the effects of mantle drag; these interactions also result in continental deformation with a complex basin-mountain architecture and evolution. The kinematics and evolution of the western Pacific subduction and northeast Asian continental-margin deformation are a first-order tectonic process whose nature and chronology remains controversial. This paper implements a "deep-time" reconstruction of the western Pacific subduction, continental accretion or collision and basin-mountain deformation in northeast Asia since 200 Ma based on a newly revised global plate model. The results demonstrate a NW-SE-oriented shortening from 200-137 Ma, a NWW-SEE-oriented extension from 136-101 Ma, a nearly N-S-oriented extension and uplift with a short-term NWW-SEE-oriented compressional inversion in northeast China from 100-67 Ma, and a NW-SE- and nearly N-S-oriented extension from 66 Ma to the present day. The western Pacific oceanic plate subducted forward under East Asia along Mudanjiang-Honshu Island during the Jurassic, and the trenches retreated to the Sikhote-Alin, North Shimanto, and South Shimanto zones from ca. 137-128 Ma, ca. 130-90 Ma, and in ca. 60 Ma, respectively. Our time-dependent analysis of plate motion and continental deformation coupling suggests that the multi-plate convergent motion and ocean-continent convergent orogeny were induced by advance subduction during the Jurassic and earliest Cretaceous. Our analysis also indicates that the intra-continent rifting and back-arc extension were triggered by trench retreat during the Cretaceous and that the subduction of oceanic ridge and arc were triggered by trench retreat during the Cenozoic. Therefore, reconstructing

  17. Chinese enterprise’s wealth effect of cross-border M&A

    Directory of Open Access Journals (Sweden)

    Yang Xingrui

    2016-01-01

    Full Text Available This paper explores the Chinese enterprises’ wealth effect of cross-border M&A and the factors which impact it. The results indicate that in the [-10, 10] event window Chinese enterprises’ get wealth effect from cross-border M&A, but in the longer event windows this wealth effect doesn’t exist. And high R&D density of the acquirer enterprises, acquisitions experience and host country’s high level of innovation have positive influence to this cumulative abnormal return, while large asset scale, high growth speed, high equity centralized degrees and horizontal acquisition mode have significant negative effects.

  18. GeoTIFF of 3x3 m Bathymetry for St. Thomas & St. John, 2011, UTM 20N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 3x3 meter resolution bathymetric surface for an area of shallow seabed surrounding St. Thomas and St....

  19. Viesnīcas "NB" izaugsmes iespēju izvērtējums Latvijas tūrisma attīstības kontekstā

    OpenAIRE

    Loseva, Aļina

    2014-01-01

    Maģistra darba tēma ir: Viesnīcas “NB” izaugsmes iespēju izvērtējums Latvijas tūrisma attīstības kontekstā. Maģistra darba mērķis ir, balstoties uz Latvijas tūrisma nozares vīziju, pamatvērtībām un stratēģiju, izpētīt viesnīcas “NB” attīstības stāvokli un izstrādāt izaugsmes stratēģiju. Darbā veikta Latvijas tūrisma un viesnīcu nozares analīze, viesnīcas “NB” finanšu analīze un tās rezultātu salīdzināšana ar nozares vidējiem rādītājiem, konkurentu analīze, viesu atsauksmju analīze, SVID an...

  20. The thumb domain is not essential for the catalytic action of HoLaMa DNA polymerase.

    Science.gov (United States)

    Gatius, Angela Gala Morena; Piaz, Fabrizio Dal; Hochkoeppler, Alejandro

    2017-12-01

    A structural and kinetic characterization of a fragment of the HoLaMa DNA polymerase is presented here. In particular, a truncated form of HoLaMa, devoid of a consistent portion of the thumb domain, was isolated and purified. This HoLaMa fragment, denoted as ΔNter-HoLaMa, is surprisingly competent in catalyzing DNA extension, albeit featuring a k cat one order of magnitude lower than the corresponding kinetic constant of its full-length counterpart. The conformational rearrangements, if any, of enzyme tryptophanes triggered by DNA binding or extension were assayed under pre-steady-state conditions. The fluorescence of HoLaMa tryptophanes was found to significantly change upon DNA binding and extension. On the contrary, no fluorescence changes of ΔNter-HoLaMa tryptophanes were detected under the same conditions, suggesting that major conformational transitions are not required for DNA binding or extension by this truncated DNA polymerase.

  1. Cyclin B degradation leads to NuMA release from dynein/dynactin and from spindle poles.

    Science.gov (United States)

    Gehmlich, Katja; Haren, Laurence; Merdes, Andreas

    2004-01-01

    The protein NuMA localizes to mitotic spindle poles where it contributes to the organization of microtubules. In this study, we demonstrate that NuMA loses its stable association with the spindle poles after anaphase onset. Using extracts from Xenopus laevis eggs, we show that NuMA is dephosphorylated in anaphase and released from dynein and dynactin. In the presence of a nondegradable form of cyclin B (Delta90), NuMA remains phosphorylated and associated with dynein and dynactin, and remains localized to stable spindle poles that fail to disassemble at the end of mitosis. Inhibition of NuMA or dynein allows completion of mitosis, despite inducing spindle pole abnormalities. We propose that NuMA functions early in mitosis during the formation of spindle poles, but is released from the spindle after anaphase, to allow spindle disassembly and remodelling of the microtubule network.

  2. Ticks on livestock in St. Lucia.

    Science.gov (United States)

    Garris, G I; Scotland, K

    1985-12-01

    Cattle, sheep, goats and horses were examined for ticks. Over 95% of Holstein cross-breeds, 28% of sheep (local mixed breeds) and 18% of goats (local mixed breeds) examined from 18 August to 4 September 1983 were infested with the southern cattle tick, Boophilus microplus Canestrini. About 90 and 17% of the horses examined were infested with the tropical horse tick, Anocentor nitens Neumann, and the tropical bont tick, Amblyomma variegatum Fabricius, respectively. The tropical bont tick was found infesting 10% of cattle in the Gros Islet area of St. Lucia. The tropical bont tick was also found associated with a severe skin disease, dermatophilosis, caused by the bacterium Dermatophilus congolensis, in 54% of the cattle infested by A. variegatum in the Gros Islet and Dauphin areas of St. Lucia.

  3. Possible Future SOFC - ST Based Power Plants

    DEFF Research Database (Denmark)

    Rokni, Masoud; Scappin, Fabio

    2009-01-01

    Hybrid systems consisting Solid Oxide Fuel Cell (SOFC) on the top of a Steam Turbine (ST) are investigated. The plants are fired by natural gas. A desulfurization reactor removes the sulfur content in the NG while a pre-reformer break down the heavier hydrocarbons. The pre-treated fuel enters the...... is considerably more than the conventional combined cycles (CC). Both ASR (Adiabatic Steam Reformer) and CPO (Catalytic Partial Oxidation) fuel reformer reactors are considered in this study.......Hybrid systems consisting Solid Oxide Fuel Cell (SOFC) on the top of a Steam Turbine (ST) are investigated. The plants are fired by natural gas. A desulfurization reactor removes the sulfur content in the NG while a pre-reformer break down the heavier hydrocarbons. The pre-treated fuel enters...

  4. Gallbladder Cancer in the 21st Century

    Directory of Open Access Journals (Sweden)

    Rani Kanthan

    2015-01-01

    Full Text Available Gallbladder cancer (GBC is an uncommon disease in the majority of the world despite being the most common and aggressive malignancy of the biliary tree. Early diagnosis is essential for improved prognosis; however, indolent and nonspecific clinical presentations with a paucity of pathognomonic/predictive radiological features often preclude accurate identification of GBC at an early stage. As such, GBC remains a highly lethal disease, with only 10% of all patients presenting at a stage amenable to surgical resection. Among this select population, continued improvements in survival during the 21st century are attributable to aggressive radical surgery with improved surgical techniques. This paper reviews the current available literature of the 21st century on PubMed and Medline to provide a detailed summary of the epidemiology and risk factors, pathogenesis, clinical presentation, radiology, pathology, management, and prognosis of GBC.

  5. Danmarks Største Fossiler

    DEFF Research Database (Denmark)

    Lindow, Bent Erik Kramer; Cuny, Gilles Guy Roger

    2008-01-01

    For 8 millioner år siden myldrede Nordsøen af en mangfoldighed af hajer, hvaler, havskildpadder og sæler, mange flere end i dag. Blandt dem finder man Danmarks største fossiler som er udstillet på Museum Sønderjylland - Naturhistorie og Palæontologi i Gram.......For 8 millioner år siden myldrede Nordsøen af en mangfoldighed af hajer, hvaler, havskildpadder og sæler, mange flere end i dag. Blandt dem finder man Danmarks største fossiler som er udstillet på Museum Sønderjylland - Naturhistorie og Palæontologi i Gram....

  6. Production et qualité nutritionnelle des épis de maïs frais bouillis ...

    African Journals Online (AJOL)

    Selon les consommateurs, la date post-récolte affecte le goût et la texture des maïs bouillis. Pour les transformatrices-vendeuses et les consommateurs, un bon maïs frais bouilli doit avoir une texture moins dure et un goût succulent. Les caractéristiques nutritionnelles du maïs frais bouilli révèlent une richesse en glucides ...

  7. Baseline risk assessment for exposure to contaminants at the St. Louis Site, St. Louis, Missouri

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    The St. Louis Site comprises three noncontiguous areas in and near St. Louis, Missouri: the St. Louis Downtown Site (SLDS), the St. Louis Airport Storage Site (SLAPS), and the Latty Avenue Properties. The main site of the Latty Avenue Properties includes the Hazelwood Interim Storage Site (HISS) and the Futura Coatings property, which are located at 9200 Latty Avenue. Contamination at the St. Louis Site is the result of uranium processing and disposal activities that took place from the 1940s through the 1970s. Uranium processing took place at the SLDS from 1942 through 1957. From the 1940s through the 1960s, SLAPS was used as a storage area for residues from the manufacturing operations at SLDS. The materials stored at SLAPS were bought by Continental Mining and Milling Company of Chicago, Illinois, in 1966, and moved to the HISS/Futura Coatings property at 9200 Latty Avenue. Vicinity properties became contaminated as a result of transport and movement of the contaminated material among SLDS, SLAPS, and the 9200 Latty Avenue property. This contamination led to the SLAPS, HISS, and Futura Coatings properties being placed on the National Priorities List (NPL) of the US Environmental Protection Agency (EPA). The US Department of Energy (DOE) is responsible for cleanup activities at the St. Louis Site under its Formerly Utilized Sites Remedial Action Program (FUSRAP). The primary goal of FUSRAP is the elimination of potential hazards to human health and the environment at former Manhattan Engineer District/Atomic Energy Commission (MED/AEC) sites so that, to the extent possible, these properties can be released for use without restrictions. To determine and establish cleanup goals for the St. Louis Site, DOE is currently preparing a remedial investigation/feasibility study-environmental impact statement (RI/FS-EIS). This baseline risk assessment (BRA) is a component of the process; it addresses potential risk to human health and the environment associated wi

  8. Pooling strategies for St Petersburg gamblers

    OpenAIRE

    Csörgö, Sandor; Simons, Gordon

    2006-01-01

    Peter offers to play exactly one St Petersburg game with each of [math] players, Paul [math] , [math] , Paul [math] , whose conceivable pooling strategies are described by all possible probability distributions [math] . Comparing infinite expectations, we characterize among all [math] those admissible strategies for which the pooled winnings, each distributed as [math] , yield a finite added value for each and every one of Paul [math] , [math] , Paul [math] in comparison with their individual...

  9. Hjertestop udløst af koronararteriespasme

    DEFF Research Database (Denmark)

    Müllertz, Katrine Mikala; Hansen, Henrik Steen

    2012-01-01

    Coronary arterial vasospasm may be associated with acute myocardial infarction, ventricular tachycardia or fibrillation as well as sudden death. Two case reports describing coronary vasospasm leading to ST-segment elevation and cardiac arrest are presented. Coronary arteriography revealed an occl...... an occlusion that disappeared after injection of nitroglycerine. Both patients were treated with calcium antagonists and a cardioverter defibrillator (ICD) was implanted. One year after the ICD implantation no tachyarrhythmias had been registered....

  10. St. Canute Lavard around the Baltic Sea

    DEFF Research Database (Denmark)

    Petersen, Nils Holger

    2018-01-01

    This chapter discusses the Baltic Sea-area manifestations of the cult of the Danish Royal saint, Canute the Duke, in Danish, Knud Lavard, during the Middle Ages. It also applies theories of cultural memory by Jan and Aleida Assmann in order to approach an understanding of how the cult of St. Canute...... was culturally re-functionalized in Denmark in the sixteenth century, but not in any similar way in other areas around the Baltic Sea....

  11. Carl Størmer Auroral Pioneer

    CERN Document Server

    Egeland, Alv

    2013-01-01

    This biography summarizes the seminal contributions to auroral and space science of Carl Størmer (1874 - 1957). He was the first to develop precise photographic methods to calculate heights and morphologies of diverse auroral forms during four solar cycles. Størmer independently devised numerical techniques to determine the trajectories of high-energy charged particles allowed and forbidden in the Earth’s magnetic field. His theoretical analyses explained cosmic ray access to the upper atmosphere, 20 years before they were identified by other scientists. Størmer’s crowning achievement, “The Polar Aurora,” published when he was 81 years old, stands to this day as a regularly cited guide in graduate-level courses on space physics.   The authors present the life of this prodigious scientist in relation to the cultural life of early 20th century in Norway and to the development of the space sciences in the post-Sputnik era.

  12. Sediment Characterization in St. Alban's Bay, VT

    Science.gov (United States)

    Nethercutt, S.; Manley, T.; Manley, P.

    2017-12-01

    St. Alban's Bay within Lake Champlain is plagued with harmful algal blooms. With future intensification due to climate change, a multidisciplinary program (BREE-Basin Resilience to Extreme Events) was initiated in 2016. In order to assess the mobilization of harmful nutrients from sediment resuspension events and riverine input, 74 sediment samples were collected in a grid fashion throughout St. Alban's Bay. Sediments were deflocculated and analyzed using a LA920 Horiba laser scattering particle size distribution analyzer to define the frequency of sediment sizes from clay to sand. Gridded surfaces of mean sortable silt percentage, silt percentage, sand percentage, and clay percentage were used to represent the sediment distribution of the region. A plot of diameter versus frequency showed the bimodal nature of some of the sediments, with one peak at about 10 microns diameter (silt) and the second at about 525 microns diameter (sand). The data showed an extremely low percentage of clay relative to that of sand and silt. The highest frequencies of sortable silt, which represents the most easily mobilized particle size, are found in the deepest areas of the bay, suggesting that these regions are where dominant bottom flow occurs. The high occurrence of sortable silt in the St. Alban's Bay does suggest that sediment mobilization, and therefore nutrient mobilization has the potential to occur. These data combined with high-resolution multibeam and hydrodynamic data will allow for future models of water flow and remobilization studies in the future.

  13. The nuclear mitotic apparatus (NuMA) protein: localization and dynamics in human oocytes, fertilization and early embryos.

    Science.gov (United States)

    Alvarez Sedó, Cristian; Schatten, Heide; Combelles, Catherine M; Rawe, Vanesa Y

    2011-06-01

    The oocyte's meiotic spindle is a dynamic structure that relies on microtubule organization and regulation by centrosomes. Disorganization of centrosomal proteins, including the nuclear mitotic apparatus (NuMA) protein and the molecular motor complex dynein/dynactin, can lead to chromosomal instability and developmental abnormalities. The present study reports the distribution and function of these proteins in human oocytes, zygotes and early embryos. A total of 239 oocytes, 90 zygotes and discarded embryos were fixed and analyzed with confocal microscopy for NuMA and dynactin distribution together with microtubules and chromatin. Microtubule-associated dynein-dependent transport functions were explored by inhibiting phosphatase and ATPase activity with sodium-orthovanadate (SOV). At germinal vesicle (GV) stages, NuMA was dispersed across the nucleoplasm. After GV breaks down, NuMA became cytoplasmic before localizing at the spindle poles in metaphase I and II oocytes. Aberrant NuMA localization patterns were found during oocyte in vitro maturation. After fertilization, normal and abnormal pronuclear stage zygotes and embryos displayed translocation of NuMA to interphase nuclei. SOV treatment for up to 2 h induced lower maturation rates with chromosomal scattering and ectopic localization of NuMA. Accurate distribution of NuMA is important for oocyte maturation, zygote and embryo development in humans. Proper assembly of NuMA is likely necessary for bipolar spindle organization and human oocyte developmental competence.

  14. Apoptotic cleavage of NuMA at the C-terminal end is related to nuclear disruption and death amplification.

    Science.gov (United States)

    Lin, Hsueh-Hsuan; Hsu, Hsin-Ling; Yeh, Ning-Hsing

    2007-09-01

    NuMA is a nuclear matrix protein in interphase and distributes to the spindle poles during mitosis. While the essential function of NuMA for mitotic spindle assembly is well established, a structural role of NuMA in interphase nucleus has also been proposed. Several observations suggest that the apoptotic degradation of NuMA may relate to chromatin condensation and micronucleation. Here we demonstrate that four apoptotic cleavage sites are clustered at a junction between the globular tail and the central coiled-coil domains of NuMA. Cleavage of a caspase-6-sensitive site at D(1705) produced the R-form, a major tail-less product of NuMA during apoptosis. The other two cleavage sites were defined at D(1726) and D(1747) that were catalyzed, respectively, by caspase-3 and an unknown aspartase. A NuMA deletion mutant missing the entire cleavage region of residues 1701-1828 resisted degradation and protected cells from nuclear disruption upon apoptotic attack. Under such conditions, cytochrome c was released from mitochondria, but the subsequent apoptotic events such as caspase-3 activation, poly(ADP-ribose) polymerase degradation, and DNA fragmentation were attenuated. Conversely, the tail-less NuMA alone, a mutant mimicking the R-form, induced chromatin condensation and activated the death machinery. It supports that intact NuMA is a structural element in maintaining nuclear integrity.

  15. 75 FR 62469 - Drawbridge Operation Regulations; Charles River, Boston, MA, Maintenance

    Science.gov (United States)

    2010-10-12

    ... Operation Regulations; Charles River, Boston, MA, Maintenance AGENCY: Coast Guard, DHS. ACTION: Notice of... Craigie Bridge across the Charles River at mile 1.0, has a vertical clearance of 10.25 feet at normal pool... temporary deviation from the regulation governing the operation of the Craigie Bridge across the Charles...

  16. 75 FR 38411 - Drawbridge Operation Regulations; Charles River, Boston, MA, Public Event

    Science.gov (United States)

    2010-07-02

    ... Operation Regulations; Charles River, Boston, MA, Public Event AGENCY: Coast Guard, DHS. ACTION: Notice of..., telephone 202-366-9826. SUPPLEMENTARY INFORMATION: The Craigie Bridge, across the Charles River at mile 1.0... elevation above the Charles River Dam. The existing drawbridge operation regulations are listed at 33 CFR...

  17. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Science.gov (United States)

    2010-10-01

    ... Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an... requirements: (i) Obtain CMS's approval of the continuation area, the marketing materials that describe the... the understanding that— (i) The ultimate responsibility for all appeals and grievance requirements...

  18. Evaluation of the peak MA-6600L microwave motion detection system

    International Nuclear Information System (INIS)

    1979-02-01

    A series of tests was performed on the Peak MA-6600L motion detection system. The primary objectives of these tests were to determine sensor detection patterns and to quantitate the effects of intruder velocity. System susceptibility to fluorescent lights, oscillatory motion, and environmental factors was also examined

  19. Preliminary Evidence for a Second -525-545 Ma old Event of ...

    African Journals Online (AJOL)

    (1995), the 630-700 Ma old event that produced the Eastern Granulites may record regional crustal thickening arising out of collision of India, Madagascar, parts of Easten Antarctica and the Kalahari craton (IMSLEK terranes) with the Congo craton and the Arabian Nubian Shield (ANS). The younger granulite event recorded ...

  20. M&A in Japan: An Analysis of Merger Waves and Hostile Takeovers

    NARCIS (Netherlands)

    D. van Schaik (Dimitri)

    2008-01-01

    textabstractThe number of mergers between large companies has been low and hostile takeover cases have been rare in post-war Japan. Since the 1990s total M&A activity is increasing in number of cases and value, and coinciding with this trend, hostile tender offer attempts are also more frequent.

  1. Anisotropic mechanical properties of the MA956 ODS steel characterized by the small punch testing technique

    Energy Technology Data Exchange (ETDEWEB)

    Turba, K., E-mail: krystof.turba@ec.europa.eu [Institute for Energy, Joint Research Centre, European Commission, Westerduinweg 3, NL-1755 LE, Petten (Netherlands); Hurst, R.C.; Haehner, P. [Institute for Energy, Joint Research Centre, European Commission, Westerduinweg 3, NL-1755 LE, Petten (Netherlands)

    2012-09-15

    Highlights: Black-Right-Pointing-Pointer Small punch testing is used to assess creep and fracture properties of MA956 ODS steel. Black-Right-Pointing-Pointer MA956 exhibits strong anisotropy in both DBTT and creep resistance at 725 Degree-Sign C. Black-Right-Pointing-Pointer High DBTT and susceptibility to thermal embrittlement potentially dangerous for applications. - Abstract: The small punch testing technique was used to assess both creep and fracture properties of the MA956 oxide dispersion strengthened ferritic steel. The anisotropy in mechanical properties was addressed, as well as the alloy's susceptibility to thermal embrittlement. Strong anisotropy was found in the material's creep resistance at 725 Degree-Sign C for longer rupture times. Anisotropic behavior was also observed for the ductile-brittle transition temperature (DBTT). The origin of the anisotropy can be related to the strongly directional microstructure which enables a large amount of intergranular cracking during straining at both high and low temperatures. The DBTT of the alloy is very high, and can be further increased by at least 200 Degree-Sign C after 1000 h of ageing at 475 Degree-Sign C, due to the formation of the Cr-rich {alpha} Prime phase. The particularly high susceptibility of the MA956 to thermal embrittlement is mainly a consequence of its high chromium content.

  2. First results from quality assurance testing of MaPMTs for the LHCb RICH upgrade

    Science.gov (United States)

    Gambetta, S.; LHCb RICH Collaboration

    2017-12-01

    In 2019 the LHCb RICH detector will be upgraded to increase the read out rate from 1 MHz to 40 MHz. As a consequence, the current Hybrid Photon Detectors will have to be replaced. Multi-anode Photomultiplier Tubes (MaPMTs) from Hamamatsu with 64-channels will be used: the 1-in. R13742 and the 2-in. R13743 MaPMTs (custom modifications of the MaPMTs R11625 and R12699). Quality assurance testing of these MaPMTs using custom-developed readout electronics has started. We present the design and realisation of the test facilities to ensure consistency in testing and validation. A total of 3100 units of the R13742 and 450 units of the R13743 will be tested requiring high efficiency and reliability from the test stations. We report on the test programme and protocols, characterising the units and assuring compliance with specifications. First results of testing and detector characterisation will be presented, based on the pre-series production, comprising 54 units of R13742 and 20 units of R13743.

  3. Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha.

    Science.gov (United States)

    Sukhai, Mahadeo A; Wu, Xuemei; Xuan, Yali; Zhang, Tong; Reis, Patricia P; Dubé, Karina; Rego, Eduardo M; Bhaumik, Mantu; Bailey, Denis J; Wells, Richard A; Kamel-Reid, Suzanne; Pandolfi, Pier Paolo

    2004-01-22

    Acute promyelocytic leukemia (APL) is characterized by the accumulation of abnormal promyelocytes in the bone marrow (BM), and by the presence of a reciprocal chromosomal translocation involving retinoic acid receptor alpha (RARalpha). To date, five RARalpha partner genes have been identified in APL. NuMA-RARalpha was identified in a pediatric case of APL carrying a translocation t(11;17)(q13;q21). Using a construct containing the NuMA-RARalpha fusion gene driven by the human cathepsin G promoter (hCG-NuMA-RARalpha), two transgenic mouse lines were generated. Transgenic mice were observed to have a genetic myeloproliferation (increased granulopoiesis in BM) at an early age, and rapidly developed a myeloproliferative disease-like myeloid leukemia. This leukemia was morphologically and immunophenotypically indistinguishable from human APL, with a penetrance of 100%. The phenotype of transgenic mice was consistent with a blockade of neutrophil differentiation. NuMA-RARalpha is therefore sufficient for disease development in this APL model.

  4. Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.

    Science.gov (United States)

    Jin, Mingyue; Pomp, Oz; Shinoda, Tomoyasu; Toba, Shiori; Torisawa, Takayuki; Furuta, Ken'ya; Oiwa, Kazuhiro; Yasunaga, Takuo; Kitagawa, Daiju; Matsumura, Shigeru; Miyata, Takaki; Tan, Thong Teck; Reversade, Bruno; Hirotsune, Shinji

    2017-01-12

    Human mutations in KATNB1 (p80) cause severe congenital cortical malformations, which encompass the clinical features of both microcephaly and lissencephaly. Although p80 plays critical roles during brain development, the underlying mechanisms remain predominately unknown. Here, we demonstrate that p80 regulates microtubule (MT) remodeling in combination with NuMA (nuclear mitotic apparatus protein) and cytoplasmic dynein. We show that p80 shuttles between the nucleus and spindle pole in synchrony with the cell cycle. Interestingly, this striking feature is shared with NuMA. Importantly, p80 is essential for aster formation and maintenance in vitro. siRNA-mediated depletion of p80 and/or NuMA induced abnormal mitotic phenotypes in cultured mouse embryonic fibroblasts and aberrant neurogenesis and neuronal migration in the mouse embryonic brain. Importantly, these results were confirmed in p80-mutant harboring patient-derived induced pluripotent stem cells and brain organoids. Taken together, our findings provide valuable insights into the pathogenesis of severe microlissencephaly, in which p80 and NuMA delineate a common pathway for neurogenesis and neuronal migration via MT organization at the centrosome/spindle pole.

  5. Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins.

    Science.gov (United States)

    Du, Quansheng; Macara, Ian G

    2004-11-12

    During asymmetric cell divisions, mitotic spindles align along the axis of polarization. In invertebrates, spindle positioning requires Pins or related proteins and a G protein alpha subunit. A mammalian Pins, called LGN, binds Galphai and also interacts through an N-terminal domain with the microtubule binding protein NuMA. During mitosis, LGN recruits NuMA to the cell cortex, while cortical association of LGN itself requires the C-terminal Galpha binding domain. Using a FRET biosensor, we find that LGN behaves as a conformational switch: in its closed state, the N and C termini interact, but NuMA or Galphai can disrupt this association, allowing LGN to interact simultaneously with both proteins, resulting in their cortical localization. Overexpression of Galphai or YFP-LGN causes a pronounced oscillation of metaphase spindles, and NuMA binding to LGN is required for these spindle movements. We propose that a related switch mechanism might operate in asymmetric cell divisions in the fly and nematode.

  6. GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA.

    Science.gov (United States)

    Harborth, J; Weber, K; Osborn, M

    2000-10-13

    The yeast two-hybrid system was used to identify binding partners of NuMA, a component of the nuclear matrix in interphase cells. By using the C-terminal half of NuMA as bait, a human cDNA sequence coding for a 223-amino acid protein with a non-helical N-terminal domain and a C-terminal alpha-helical portion was identified and fully sequenced. It was identical to GAS41, a sequence amplified in human gliomas. The sequence of the homologous Drosophila protein was established, and the alignment for GAS41 from nine different species showed that GAS41 is a general eukaryotic protein found in species as diverse as Arabidopsis, Drosophila, Caenorhabditis elegans, yeast, and man. Northern blot analysis showed a single transcript in eight human tissues. A polyclonal antibody to GAS41 showed a dotted staining pattern in interphase nuclei and a uniform distribution in mitotic cells. A GFP-GAS41 fusion protein displayed equivalent patterns. In vitro GAS41 bound to the C-terminal part of the rod region of NuMA, as shown by dot overlay and by surface plasmon resonance measurements. The K(d) of the complex was 2 x 10(-)(7) m. GAS41 is related to the AF-9 and ENL proteins, which are putative transcription factors found as fusion proteins in some acute leukemias. The NuMA/GAS41 interaction may provide a link between nuclear structure and gene expression.

  7. Regulation of mitotic spindle assembly factor NuMA by Importin-β.

    Science.gov (United States)

    Chang, Chih-Chia; Huang, Tzu-Lun; Shimamoto, Yuta; Tsai, Su-Yi; Hsia, Kuo-Chiang

    2017-11-06

    Ran-guanosine triphosphatase orchestrates mitotic spindle assembly by modulation of the interaction between Importin-α/-β and spindle assembly factors (SAFs). The inhibition of SAFs performed by importins needs to be done without much sequestration from abundant nuclear localization signal (NLS) -containing proteins. However, the molecular mechanisms that determine NLS-binding selectivity and that inhibit activity of Importin-β-regulated SAFs (e.g., nuclear mitotic apparatus protein [NuMA]) remain undefined. Here, we present a crystal structure of the Importin-α-NuMA C terminus complex showing a novel binding pattern that accounts for selective NLS recognition. We demonstrate that, in the presence of Importin-α, Importin-β inhibits the microtubule-binding function of NuMA. Further, we have identified a high-affinity microtubule-binding region that lies carboxyl-terminal to the NLS, which is sterically masked by Importin-β on being bound by Importin-α. Our study provides mechanistic evidence of how Importin-α/-β regulates the NuMA functioning required for assembly of higher-order microtubule structures, further illuminating how Ran-governed transport factors regulate diverse SAFs and accommodate various cell demands. © 2017 Chang et al.

  8. Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly.

    Science.gov (United States)

    Chang, Paul; Coughlin, Margaret; Mitchison, Timothy J

    2009-11-01

    Poly(ADP-ribose) (pADPr), made by PARP-5a/tankyrase-1, localizes to the poles of mitotic spindles and is required for bipolar spindle assembly, but its molecular function in the spindle is poorly understood. To investigate this, we localized pADPr at spindle poles by immuno-EM. We then developed a concentrated mitotic lysate system from HeLa cells to probe spindle pole assembly in vitro. Microtubule asters assembled in response to centrosomes and Ran-GTP in this system. Magnetic beads coated with pADPr, extended from PARP-5a, also triggered aster assembly, suggesting a functional role of the pADPr in spindle pole assembly. We found that PARP-5a is much more active in mitosis than interphase. We used mitotic PARP-5a, self-modified with pADPr chains, to capture mitosis-specific pADPr-binding proteins. Candidate binding proteins included the spindle pole protein NuMA previously shown to bind to PARP-5a directly. The rod domain of NuMA, expressed in bacteria, bound directly to pADPr. We propose that pADPr provides a dynamic cross-linking function at spindle poles by extending from covalent modification sites on PARP-5a and NuMA and binding noncovalently to NuMA and that this function helps promote assembly of exactly two poles.

  9. Cell Division: NuMA Bears the Load in the Spindle.

    Science.gov (United States)

    Maiato, Helder; Pereira, António J

    2017-08-07

    The mitotic spindle bears the load of chromosomes during mitosis, but how this load is distributed across the spindle is unclear. A new study shows that load distribution in the spindle is confined and requires the microtubule cross-linking protein NuMA. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. El jaciment paleolític de Cal Coix (Maçanet de la Selva)

    OpenAIRE

    Soler i Masferrer, Narcís

    1982-01-01

    Descripció del jaciment arqueològic de Cal Coix, al terme municipal de Maçanet de la Selva. Es descriuen els fragments trobats pel seu descobridor, Francerc Riuró, i per Miquel Oliva i Josep M.Corominas, i dipositats al Museu Arqueològic Provincial de Girona

  11. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Portland Head, ME to Cape Ann, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.115 Portland Head, ME to Cape Ann... to Halibut Point at Cape Ann. (b) A line drawn from the southernmost tower on Gerrish Island charted...

  12. Chronic N-amended soils exhibit an altered bacterial community structure in Harvard Forest, MA, USA

    Science.gov (United States)

    Swathi A. Turlapati; Rakesh Minocha; Premsai S. Bhiravarasa; Louise S. Tisa; William K. Thomas; Subhash C. Minocha

    2013-01-01

    At the Harvard Forest, Petersham, MA, the impact of 20 years of annual ammonium nitrate application to the mixed hardwood stand on soil bacterial communities was studied using 16S rRNA genes pyrosequencing. Amplification of 16S rRNA genes was done using DNA extracted from 30 soil samples (three treatments x two horizons x five subplots) collected from untreated (...

  13. 76 FR 42545 - Regulated Navigation Area; Chelsea Street Bridge Construction, Chelsea, MA

    Science.gov (United States)

    2011-07-19

    ...-AA11 Regulated Navigation Area; Chelsea Street Bridge Construction, Chelsea, MA AGENCY: Coast Guard... navigable waters during the construction of the Chelsea Street Bridge. DATES: This rule is effective in the... questions or comments, during the bridge construction. We will provide written summaries of any such...

  14. 76 FR 65376 - Regulated Navigation Area; Chelsea Street Bridge Construction, Chelsea, MA

    Science.gov (United States)

    2011-10-21

    ...-AA11 Regulated Navigation Area; Chelsea Street Bridge Construction, Chelsea, MA AGENCY: Coast Guard... opportunity for public questions or comments, during the bridge construction. We will provide written... Area (RNA) on the navigable waters of the Chelsea River under and surrounding the Chelsea Street Bridge...

  15. Gun Carrying by High School Students in Boston, MA: Does Overestimation of Peer Gun Carrying Matter?

    Science.gov (United States)

    Hemenway, David; Vriniotis, Mary; Johnson, Renee M.; Miller, Matthew; Azrael, Deborah

    2011-01-01

    This paper investigates: (1) whether high school students overestimate gun carrying by their peers, and (2) whether those students who overestimate peer gun carrying are more likely to carry firearms. Data come from a randomly sampled survey conducted in 2008 of over 1700 high school students in Boston, MA. Over 5% of students reported carrying a…

  16. Ma'atic Beauty: Ethics and Aesthetics of the Ancient Egyptians in Ayi ...

    African Journals Online (AJOL)

    Consensus among archeologists exhibits the idea that Ma'at for Kemetic peoples (ancient Egyptians) stands for the fundamental order of the universe. It organized the ancient Egyptian world and made it spiritually and artistically sui generis. In his last two novels, the Ghanaian novelist Ayi Kwei Armah, deploys the ancient ...

  17. Fabrication Technological Development of the Oxide Dispersion Strengthened Alloy MA957 for Fast Reactor Applications

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, Margaret L.; Gelles, David S.; Lobsinger, Ralph J.; Johnson, Gerald D.; Brown, W. F.; Paxton, Michael M.; Puigh, Raymond J.; Eiholzer, Cheryl R.; Martinez, C.; Blotter, M. A.

    2000-02-28

    A significant amount of effort has been devoted to determining the properties and understanding the behavior of the alloy MA957 to define its potential usefulness as a cladding material in the fast breeder reactor program. The numerous characterization and fabrication studies that were conducted are documented in this report.

  18. Asymmetries in conditional mean and variance: Modelling stock returns by asMA-asQGARCH

    NARCIS (Netherlands)

    Brännäs, K.; de Gooijer, J.G.

    2000-01-01

    The asymmetric moving average model (asMA) is extended to allow for asymmetric quadratic conditional heteroskedasticity (asQGARCH). The asymmetric parametrization of the condi- tional variance encompasses the quadratic GARCH model of Sentana (1995). We introduce a framework for testing asymmetries

  19. Application of {sup 13}C NMR spectroscopy for assessment of conversion factor in copolymers: S/MA; S/MMA, MS/MA, MS/MMA; Zastosowanie spektroskopii {sup 13}C-NMR do oceny stopnia przemiennosci kopolimerow S/MA, S/MMA, MS/MA, MS/MMA

    Energy Technology Data Exchange (ETDEWEB)

    Chmielewski, A.; Zurakowska-Orszagh, J. [Instytut Przemyslu Gumowego ``Stomil``, Piastow (Poland); Makulski, W. [Faculty of Chemistry, Warsaw Univ. (Poland)

    1994-12-31

    {sup 13} C NMR has been used for investigation of copolymerization process. The molecular structure otherwise the mere sequence in copolymer chain has been defined in four systems as follows: S/MA, S/MMA, MS/MMA and MS/MMA. 19 refs, 6 figs, 3 tabs.

  20. Hubungan Religiusitas dan Kebahagiaan dengan Motivasi Belajar Santri di MA Mu’allimin Yogyakarta

    Directory of Open Access Journals (Sweden)

    Rania Melani

    2016-12-01

    Full Text Available This study motivated their learning motivation often decreased due to; They have to follow different school rules, they just hang out with their male friends, they will be sanctioned if they make mistakes, lack the motivation to perform best because of the homogeneity of the students in school, the lack of time to get along with the family and you. This research aims to know relation of religiosity and happiness with learning motivation at santri in MA mu'allimin Yogyakarta, religiosity relationship with motivation to learn at santri at MA Mu'allimin Yogyakarta, happiness relationship with motivation to learn at santri at MA Mu'allimin Yogyakarta. The method used is quantitative research method. The subject of this research is santri MA Mu'allimin Yogyakarta academic year 2014-2015. Data collection techniques are with the scale of learning motivation, religiosity and happiness. The method of analysis used in this study is multiple linear regression, using the help of SPSS 19.0 for windows. The results of this study: the relationship of religiosity and happiness to the motivation of learning, a significant relationship between religiosity with learning motivation, and the relationship between happiness with learning motivation.

  1. A Naturalistic Inquiry into the Cultures of Two Divergent MA-TESOL Programs: Implications for TESOL.

    Science.gov (United States)

    Ramanathan, Vai; Davies, Catherine Evans; Schleppegrell, Mary J.

    2001-01-01

    Reports a comparison of two MA-TESOL programs and suggests some implications of the findings for the TESOL profession. Based on interviews, observations, and written documentation, characteristics of two of the programs are identified that are associated with the larger departments in which the programs are housed. (Author/VWL)

  2. Evidence of the proto-Iceland plume in northwestern Ireland at 42 Ma from helium isotopes

    NARCIS (Netherlands)

    Kirstein, L.A.; Timmerman, M.J.

    2000-01-01

    Combined K-Ar and Ar-Ar dating of a xenolith-bearing alkaline dyke, previously considered to be of late Palaeozoic age, suggest a mid-Eocene age of c. 43 Ma, indicating that it is part of extensive rift-related Tertiary intrusive activity. High

  3. [Usāma ibn Munqidh. Õpetlike näidete raamat

    Index Scriptorium Estoniae

    2016-01-01

    Tutvustus: Usāma ibn Munqidh. Õpetlike näidete raamat : Araabia rüütli mälestused / araabia k. tõlkinud ja kommenteerinud Üllar Peterson. Tallinn : Tallinna Ülikooli Kirjastus, 2015. (Bibliotheca Asiatica)

  4. Preparation of Poly(MA-alt-α-olefin-C6,8,12,18)

    Indian Academy of Sciences (India)

    form solution by methanol. Poly(MA-alt-1-octadecene). (C18) was supplied from Aldrich with Mn = 30000–. 50000 g mol−1. All other solvents and reagents were of analytical grade and used without purifi- cation. γ-Aminopropyltrimethoxysilane (APTS) and tetraethoxysilane (tetraethyl orthosilicate) (TEOS) were obtained ...

  5. Design of 500 keV/10 mA electron beam machine

    International Nuclear Information System (INIS)

    Sudjatmoko; Sugiarto, Sutadji; Darsono; Sudiyanto

    1999-01-01

    A 500 KeV/10 mA Ion Energy Electron Beam Machine Unit was designed which its components consisted of : electron source, electron beam focusing system, high voltage supply, accelerator tube, electron beam scanning system and vacuum system. The electron source was a hot cathode type made of spiral tungsten wire that capable to produce at least 10 mA electron beam current. The electron beam focussing system used to focus electron beam coming from electron source, and second focussing system used to focus electron beam coming from accelerator tube. The high voltage supply for electron beam acceleration was a Cockroff-Walton generator type having 20 step voltage multifier capable to produce 500 keV/10 mA output. The accelerator tube consisted of pyrex glass insulator tubes and stainless steel electrodes, the electrodes were 34 plates so that each electrode was given a voltage distribution not more than 15 kV. The electron beam scanning system was an alternating magnetic field having 20 o deflection angle, 920 coil turn and 0.012 W/m 2 magnetic field intensity. The vacuum system for this 500 keV/10 mA EBM was designed to be a two step rotary pump of 14.6 m 3 /hour and a turbo molecular pump of 280 l/minute, to achieve a vacuum of 10 -6 torr. (author)

  6. absolute migration of pacific basin mid-ocean ridges since 85 ma ...

    African Journals Online (AJOL)

    Mgina

    Pacific plate drift direction at 43 Ma. The interpretation proposed above, is also important in explaining the collision of the. EPR with North America. Mid-ocean ridges are buoyant features therefore under normal conditions they will tend to run away from closely approaching continents or trenches, probably like the Juan de ...

  7. Identifying M&A targets and the information content of VC/PEs

    Directory of Open Access Journals (Sweden)

    Qingquan Tang

    2018-03-01

    Full Text Available The information gap in the M&A market hinders acquirers from effectively identifying high-quality targets. We examine whether VC/PEs convey information content in the M&A market and whether acquirers can use such information to identify high-quality targets. We show that VC/PEs have significant information content and can signal high-quality target companies via “certification”. When acquirers lack acquisition experience and targets are located in inferior information environments, VC/PE “certification” is more significant. The better reputation a VC/PE has, the more information it conveys. Syndicate VC/PEs convey stronger information than independent VC/PEs. We also find that acquirers do not pay higher premiums for high-quality targets. Overall, our results suggest that VC/PEs have value relevance in the M&A market, confirming their “certification” role. We present means for acquirers to select high-quality targets and investors to build efficient portfolios. Keywords: M&A, Certification, VC/PEs, Information content

  8. redMaGiC: selecting luminous red galaxies from the DES Science Verification data

    Energy Technology Data Exchange (ETDEWEB)

    Rozo, E. [Univ. of Arizona, Tucson, AZ (United States). et al.

    2016-05-30

    We introduce redMaGiC, an automated algorithm for selecting Luminous Red Galaxies (LRGs). The algorithm was developed to minimize photometric redshift uncertainties in photometric large-scale structure studies. redMaGiC achieves this by self-training the color-cuts necessary to produce a luminosity-thresholded LRG sam- ple of constant comoving density. Additionally, we demonstrate that redMaGiC photo-zs are very nearly as accurate as the best machine-learning based methods, yet they require minimal spectroscopic training, do not suffer from extrapolation biases, and are very nearly Gaussian. We apply our algorithm to Dark Energy Survey (DES) Science Verification (SV) data to produce a redMaGiC catalog sampling the redshift range z ϵ [0.2,0.8]. Our fiducial sample has a comoving space density of 10-3 (h-1Mpc)-3, and a median photo-z bias (zspec zphoto) and scatter (σz=(1 + z)) of 0.005 and 0.017 respectively.The corresponding 5σ outlier fraction is 1.4%. We also test our algorithm with Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8) and Stripe 82 data, and discuss how spectroscopic training can be used to control photo-z biases at the 0.1% level.

  9. 75 FR 10500 - Environmental Assessment Prepared for Proposed Cape Wind Energy Project in Nantucket Sound, MA

    Science.gov (United States)

    2010-03-08

    ... Proposed Cape Wind Energy Project in Nantucket Sound, MA AGENCY: Minerals Management Service (MMS... MMS for the Cape Wind Energy Project proposed for Nantucket Sound, Massachusetts. On January 16, 2009... facility on Horseshoe Shoal in Nantucket Sound, Massachusetts. Following the adoption of the Energy Policy...

  10. 76 FR 37005 - Safety Zone; Fan Pier Yacht Club Fireworks, Boston Harbor, Boston, MA

    Science.gov (United States)

    2011-06-24

    ..., design, or operation; test methods; sampling procedures; and related management systems practices) that...-AA00 Safety Zone; Fan Pier Yacht Club Fireworks, Boston Harbor, Boston, MA AGENCY: Coast Guard, DHS... Sector Boston Captain of the Port (COTP) Zone for the Fan Pier Yacht Club Fireworks display. This safety...

  11. 42 CFR 422.322 - Source of payment and effect of MA plan election on payment.

    Science.gov (United States)

    2010-10-01

    ... technology are made from the Federal Hospital Insurance Trust Fund or the Supplementary Medical Insurance... 42 Public Health 3 2010-10-01 2010-10-01 false Source of payment and effect of MA plan election on payment. 422.322 Section 422.322 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF...

  12. Industrial chains and innovation activity in Małopolska region in 2008-2010

    Directory of Open Access Journals (Sweden)

    Świadek Arkadiusz

    2014-05-01

    Full Text Available Znaczenie powiązań przemysłowych dla aktywności innowacyjnej przedsiębiorstw w regionie małopolskim w latach 2008-2010 Głównym celem prowadzonych badań była próba poszukiwania zmiennych warunków wpływu łańcuchów dostaw na działalność innowacyjną przedsiębiorstw w obrębie wybranego regionalnego systemu przemysłowego, a tym samym określenie warunków brzegowych dla modelu regionalnej sieci innowacji, biorąc pod uwagę specyfikę województwa małopolskiego. Badanie zostało oparte na kwestionariuszu ankietowym i wykonane na grupie 500 firm z Małopolski. W badaniu wykorzystano modelowanie probitowe. Metoda ta jest skutecznym narzędziem analizy dużych, ale statycznych prób, w których zmienna zależna ma charakter jakościowy.

  13. Cold Gas in Quenched Dwarf Galaxies using HI-MaNGA

    Science.gov (United States)

    Bonilla, Alaina

    2017-01-01

    MaNGA (Mapping of Nearby Galaxies at Apache Point Observatory) is a 6-year Sloan Digital Sky Survey fourth generation (SDSS-IV) project that will obtain integral field spectroscopy of a catalogue of 10,000 nearby galaxies. In this study, we explore the properties of the passive dwarf galaxy sample presented in Penny et al. 2016, making use of MaNGA IFU (Integral Field Unit) data to plot gas emission, stellar velocity, and flux maps. In addition, HI-MaNGA, a legacy radio-survey of MaNGA, collects single dish HI data retrieved from the GBT (Green Bank Telescope), which we use to study the the 21cm emission lines present in HI detections. Studying the HI content of passive dwarves will help us reveal the processes that are preventing star formation, such as possible AGN feedback. This work was supported by the SDSS Research Experience for Undergraduates program, which is funded by a grant from the Sloan Foundation to the Astrophysical Research Consortium.

  14. An Introspection for the Field of IS Integration Challenges in M&A

    DEFF Research Database (Denmark)

    Toppenberg, Gustav; Henningsson, Stefan

    2013-01-01

    The last decade has seen a rise in research on the topic of challenges associated with information systems (IS) in corporate mergers and acquisitions (M&As). Although this proliferation of research has the potential to significantly improve our understanding of IS challenges in M&A activity, absent...

  15. The Moderating Effects of Decision-making Preference on M&A Integration Speed and Performance

    DEFF Research Database (Denmark)

    Uzelac, Boris; Bauer, Florian; Matzler, Kurt

    2016-01-01

    This paper illustrates the effects of post-merger integration speed on M&A performance and the moderating role of decision-making preferences. For a better understanding of the effects of integration speed, we separate the role of human and task integration speed. The results, obtained from...

  16. Searching for New Directions: Developing MA Action Research Project as a Tool for Teaching

    Science.gov (United States)

    Lee, Young Ah; Wang, Ye

    2012-01-01

    Action research has been recognized as a useful professional development tool for teaching, but for inservice teachers, conducting action research can be challenging. Their learning about action research can be influenced by social situations--whether in an MA (Master of Arts) program or other professional development. The purpose of this…

  17. 76 FR 3516 - Drawbridge Operation Regulations; Merrimack River, Newburyport and Salisbury, MA

    Science.gov (United States)

    2011-01-20

    ... Salisbury, MA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulations. SUMMARY: The... Salisbury, Massachusetts. The deviation is necessary to paint the bridge. This deviation allows the bridge... Newburyport US1 Bridge, across the Merrimack River at mile 3.4, between Newburyport and Salisbury...

  18. Absolute migration of Pacific basin mid-ocean ridges since 85 Ma ...

    African Journals Online (AJOL)

    Mid-ocean ridges are major physiographic features that dominate the world seafloor. Their absolute motion and tectonics are recorded in magnetic lineations they created. The absolute migration of mid-ocean ridges in the Pacific basin since 85 Ma and their tectonic implications was investigated in this work and the results ...

  19. Why was the ma<^16t collection (Ps 120-134) written?

    African Journals Online (AJOL)

    With what purpose was the ma<^lot collection written? In the past different answers were given. A few viewpoints will suffice (cf Viviers 1990; Day 1990): Liebreich. (1955) views these fifteen psalms as the commentary of the people on the Aaronite benediction (Num 6:24-26) pronounced on the steps of the temple court.

  20. Oh oleksin ma rikas! : [luuletused] / Hans Christian Andersen ; tlk. Harald Rajamets

    Index Scriptorium Estoniae

    Andersen, Hans Christian, 1805-1875

    2004-01-01

    Sisu: Oh oleksin ma rikas! ; Tädi prillid ; "Oh vägev surm, sa külvad tummalt õudu..." ; "Meil maa peal elu kurblik näib..." ; "Kõik kaob nagu tuul siin ära..." ; "Lund on veel maas ja vahel teeb tuisku..."

  1. 77 FR 19573 - Safety Zone; Wedding Fireworks Display, Boston Inner Harbor, Boston, MA

    Science.gov (United States)

    2012-04-02

    ...-AA00 Safety Zone; Wedding Fireworks Display, Boston Inner Harbor, Boston, MA AGENCY: Coast Guard, DHS... for a wedding fireworks display. This temporary safety zone is necessary to protect spectators and... Proposed Rule Ocean State Pyrotechnics, Inc is sponsoring a wedding fireworks display on the waters of...

  2. Design and Facilitation of Problem-Based Learning in Graduate Teacher Education: An MA TESOL Case

    Science.gov (United States)

    Caswell, Cynthia Ann

    2016-01-01

    This exploratory, evaluative case study introduces a new context for problem-based learning (PBL) involving an iterative, modular approach to curriculum-wide delivery of PBL in an MA TESOL program. The introduction to the curriculum context provides an overview of the design and delivery features particular to the situation. The delivery approach…

  3. Orogenesis and Basin Development: U-Pb Detrital Zircon Age Constraints on Evolution of the Late Paleozoic St. Marys Basin, Central Mainland Nova Scotia.

    Science.gov (United States)

    Murphy; Hamilton

    2000-01-01

    The St. Marys Basin, along the southern flank of the composite Late Paleozoic Magdalen Basin in the Canadian Appalachians and along the Avalon-Meguma terrane boundary, contains Late Devonian-Early Carboniferous continental clastic rocks of the Horton Group that were deposited in fluvial and lacustrine environments after the peak of the Acadian orogeny. SHRIMP II (Geological Survey of Canada) data on approximately 100 detrital zircons from three samples of Horton Group rocks from the St. Marys Basin show that most of the zircons have been involved in a multistage history, recycled from clastic rocks in the adjacent Meguma and Avalonian terranes. Although there is a minor contribution from Early Silurian (411 Ma) and Late Devonian suites (ca. 380-370 Ma), Neoproterozoic (ca. 700-550 Ma) and Paleoproterozoic (ca. 2.0-2.2 Ga) zircon populations predominate, with a minor contribution from ca. 1.0-, 1.2-, and 1.8-Ga zircons. Published U-Pb single-zircon analyses on clastic sedimentary rocks indicate that the Meguma and Avalon terranes have different populations of detrital zircons, sourced from discrete portions (Amazonian and West African cratons) of the ancient Gondwanan margin. Both terranes contain Neoproterozoic and Late Archean populations. The SHRIMP data, in conjunction with published sedimentological and geochemical data, indicate that the Horton Group basin-fill sediments are largely the result of rapid uplift and erosion of Meguma terrane metasedimentary and granitoid rocks immediately to the south of the St. Marys Basin during the waning stages of the Acadian orogeny. Regional syntheses indicate that this uplift occurred before and during deposition and was a consequence of dextral ramping of the Meguma terrane over the Avalon terrane along the southern flank of the Magdalen Basin.

  4. Under-performance of listed companies? Real earnings management and M&A: Chinese empirical evidence

    Directory of Open Access Journals (Sweden)

    Ziqiao Zhang

    2015-04-01

    Full Text Available Purpose: The purpose of this paper is to examine whether acquiring firms attempt to adopt real earnings management strategy to upward reported earnings in the period of M&A announcement and provide an explanation for the underperformance of post-M&A in share payment M&A affairs occurring in China’s capital market from 2008-2010. Design/methodology/approach: The author uses Roychowdhury’s(2006 methodology to measure the magnitude of real earnings management of acquiring firms in stock for stock M&A by exploiting financial date from 2006 to 2011. The methodology includes three models, which are cash ?ow from operations, production costs and discretionary expenditures, respectively. Findings: It was found that firms using stock as a financing medium exhibit significant negative abnormal cash flows and abnormal discretionary expenses yet abnormal production costs significantly positive during the current period of M&A. Moreover, it was also documented that acquiring firms use real activities manipulation to overstate earnings for the purpose of improving market confidence. Finally, a negative association was found between REM and under-performance of post-M&A. Research limitations/implications: To some extent, these results explain the puzzle of performance decline over the following period of post-M&A. Meanwhile, our study adds to prior literature that capital market pressures induce acquiring firms inflate reported earnings by manipulating real activities in stock-financed M&A occurring in China’s capital market. Practical implications: The author’s result imply that investors, analysts and regulators cannot ignore more undetectable opportunism behaviors underlying reported earnings than accrual-based earnings management and the impact on the performance of post-M&A when they use financial statements to evaluate acquiring firms. Social implications: Our study plays important role in making public policies. Furthermore, it is necessary to

  5. Pfister y la Hibridación del Maíz

    Directory of Open Access Journals (Sweden)

    Kent. George

    1940-03-01

    Full Text Available En la Facultad Nacional de Agronomía, se están haciendo actualmente los trabajos de aclimatación del "maíz hibrido Pfister". Cuando el suscrito tuvo conocimiento del "maíz híbrido" obtenido como fruto de una experimentación de más de 20 años llevada a cabo en Illinois por el señor Pfister, se interesó vivamente en traer unas semillas a Colombia para intentar el proceso de aclimatación de las mejores variedades. A pesar de una larga correspondencia con el señor Pfister desde hace dos años, no nos fue posible lograr nuestro objeto. Durante la última visita del suscrito a ese país, obtuve, como una merced personal, una muy pequeña cantidad de las ocho mejores variedades de maíz híbrido, y al efecto, a la presente le estoy incluyendo a usted esas semillas de maíz sin otra retribución para nosotros, que el de hacer las siembras, observaciones y experimentaciones con todo el cuidado de que usted es capaz, y darnos cuenta oportuna de los resultados obtenidos con cada una de las variedades. Cada talego está marcado con el número de la variedad y no está por demás rogar a usted de la manera más encarecida llevar a efecto este trabajo con el mayor cuidado e interés para corresponder por lo menos al que hemos tenido nosotros en proporcionarle las dichas semillas. A pesar de que en Estados Unidos han hecho una súper selección de maíz en los últimos 50 años, las semillas seleccionadas han; quedado superadas por el maíz "Híbrido Pfister" con rendimientos de más de un 60%. Como nosotros no hemos hecho nada en selección de maíz, nuestro trabajo se puede limitar a un proceso de "aclimatación", que si logramos, tendríamos ganados muchos años de trabajo.

  6. Geist, Logik, Kapital und die Technik des Maßes

    Directory of Open Access Journals (Sweden)

    Frank Engster

    2017-02-01

    Full Text Available Hegels Phänomenologie des Geistes (PhdG und seine Wissenschaft der Logik (WdL sowie Marx Kapital sind, so wird im ersten Teil gezeigt, jeweils Ausdruck einer Verlegenheit. Alle drei stehen nämlich vor der Herausforderung, in Geist, Logik und Kapital letztlich eine Methode darstellen zu müssen, und sie müssen darüber auch noch die Möglichkeit der Darstellung ebendieser Methode einholen und begründen. Diese Übereinkunft zwischen der Methode der Darstellung mit dem Methodischen aufseiten des dargestellten Geistes, der Logik und des Kapitals gelingt, so die These des zweiten Teils, durch die Technik des Maßes. Maß und Messung konstituieren bereits in der Naturwissenschaft Objektivität im neuzeitlichen Sinne: Gehalten an und gebrochen durch ihre eigenen Maß, werden die Verhältnisse der Natur durch die ermittelten Werte wie ein selbständiger Gegenstand objektiv bestimmbar und im Wissen subjektiv aufgehoben. Dagegen zeigen Geist, Logik und Kapital jeweils, dass die Technik des Maßes nicht nur Objektivität im neuzeitlichen Sinne konstituiert, sondern die gesamte neuzeitliche Form der Gegenständlichkeit von Objektivität und Subjektivität, Bewusstsein und Gegenstand. In Hegels Phänomenologie und seiner Logik sowie in Marx Kapital eröffnet das Maß diese Gegenständlichkeit, indem jeweils eine Objektivität konstituiert wird, die einem Subjekt buchstäblich zu denken gegeben wird. Es ist allerdings unmittelbar die Objektivität der Subjektivität selbst, die jeweils gegeben wird: phänomenologisch wird durch das Maß die Objektivität der Subjektivität des Geistes gegeben (PhdG, rein logisch wird die Objektivität des Seins durch die Subjektivität des Begriffs gegeben (WdL, und der kapitalistischen Gesellschaft ist durch quantitative Werte die eigene Objektivität gegeben, und zwar gegeben durch ein Geld, das dadurch zu einer überindividuellen, automatischen Subjektivität wird. Für das Maß steht in der Phänomenologie das

  7. SDSS-IV MaNGA: Probing the Kinematic Morphology–Density Relation of Early-type Galaxies with MaNGA

    Science.gov (United States)

    Greene, J. E.; Leauthaud, A.; Emsellem, E.; Goddard, D.; Ge, J.; Andrews, B. H.; Brinkman, J.; Brownstein, J. R.; Greco, J.; Law, D.; Lin, Y.-T.; Masters, K. L.; Merrifield, M.; More, S.; Okabe, N.; Schneider, D. P.; Thomas, D.; Wake, D. A.; Yan, R.; Drory, N.

    2017-12-01

    The “kinematic” morphology–density relation for early-type galaxies posits that those galaxies with low angular momentum are preferentially found in the highest-density regions of the universe. We use a large sample of galaxy groups with halo masses {10}12.5MaNGA) survey to examine whether there is a correlation between local environment and rotational support that is independent of stellar mass. We find no compelling evidence for a relationship between the angular momentum content of early-type galaxies and either local overdensity or radial position within the group at fixed stellar mass.

  8. Cordycepin Induced MA-10 Mouse Leydig Tumor Cell Apoptosis through Caspase-9 Pathway

    Directory of Open Access Journals (Sweden)

    Chun-Yi Jen

    2011-01-01

    Full Text Available In the present study, the apoptotic effect of cordycepin on MA-10 cells, a mouse Leydig tumor cell line, was investigated. Results demonstrated that the number of rounding-up cell increased by cordycepin (10 μM to 5 mM for 24 h, and cells with plasma membrane blebbing could be observed by 100 μM cordycepin. In viability test, MA-10 cell surviving rate significantly decreased as the dosage (10 μM to 5 mM and duration (3–24 h of cordycepin treatment increased (P < 0.05. Cordycepin at 100 μM and 1 mM for 24 h treatment induced significant DNA fragmentation (P < 0.05. In addition, the percentage of G1 and G2/M phase cell significantly declined by cordycepin (100 μM and 1 mM for 24 h treatment, while the percentages of subG1 phase cell increased by 100 μM and/or 1 mM cordycepin in 6, 12 and 24 h treatments (P < 0.05, respectively, which highly suggested that cordycepin induced MA-10 cell apoptosis. In mechanism study with the treatments of caspases, c-Jun NH2 terminal kinase (JNK or reactive oxygen species (ROS inhibitors plus cordycepin for 24 h, only caspases inhibitor suppressed subG1 phase in MA-10 cells. Moreover, western blotting results showed that cordycepin induced caspase-9, -3 and -7 protein expressions, but not caspase-8, in time- and dose-dependent manners. In conclusion, cordycepin induced apoptosis in MA-10 mouse Leydig tumor cells through a caspase-9 and -3 and -7 dependent pathway.

  9. Association of the NuMA region on chromosome 11q13 with breast cancer susceptibility.

    Science.gov (United States)

    Kammerer, Stefan; Roth, Richard B; Hoyal, Carolyn R; Reneland, Richard; Marnellos, George; Kiechle, Marion; Schwarz-Boeger, Ulrike; Griffiths, Lyn R; Ebner, Florian; Rehbock, Joachim; Cantor, Charles R; Nelson, Matthew R; Braun, Andreas

    2005-02-08

    The development of breast cancer is a complex process that involves multiple genes at many stages, from initial cell cycle dysregulation to disease progression. To identify genetic variations that influence this process, we conducted a large-scale association study using a collection of German cases and controls and >25,000 SNPs located within 16,000 genes. One of the loci identified was located on chromosome 11q13 [odds ratio (OR)=1.85, P=0.017]. The initial association was subsequently tested in two independent breast cancer collections. In both sample sets, the frequency of the susceptibility allele was increased in the cases (OR=1.6, P=0.01). The susceptibility allele was also associated with an increase in cancer family history (P=0.1). Fine mapping showed that the region of association extends approximately 300 kb and spans several genes, including the gene encoding the nuclear mitotic apparatus protein (NuMA). A nonsynonymous SNP (A794G) in NuMA was identified that showed a stronger association with breast cancer risk than the initial marker SNP (OR=2.8, P=0.005 initial sample; OR=2.1, P=0.002 combined). NuMA is a cell cycle-related protein essential for normal mitosis that is degraded in early apoptosis. NuMA-retinoic acid receptor alpha fusion proteins have been described in acute promyelocytic leukemia. Although the potential functional relevance of the A794G variation requires further biological validation, we conclude that variations in the NuMA gene are likely responsible for the observed increased breast cancer risk.

  10. Evolution of Mediterranean sea surface temperatures 3.5-1.5 Ma: Regional and hemispheric influences

    Science.gov (United States)

    Herbert, Timothy D.; Ng, Gideon; Cleaveland Peterson, Laura

    2015-01-01

    We present a composite time series of Mediterranean sea surface temperature (SST) and marine biomarker accumulation for the time span from 3.5 to 1.525 Ma, based on alkenone unsaturation and concentration from hemipelagic sediments outcropping in southern Italy and Sicily. Paleotemperature data define three regimes: a late Pliocene climate on average 4- 5 °C warmer than modern, a latest Pliocene to early Pleistocene onset of 41 kyr cycles, and a major increase in the range of glacial-interglacial temperature change at ∼ 1.84 Ma that shortly precedes the former definition of the Plio-Pleistocene boundary in the Crotone sequence. Pliocene sea surface temperature (SST) cycles are dominated by precession, with a ∼ 1.5 °C range. Obliquity-related rhythms influence SST significantly shortly after ∼ 2.8 Ma (equivalent to MIS G10) and dominate after ∼ 2.51 Ma (equivalent to MIS 100). However, little, if any, long-term cooling occurred on an interglacial basis until after ∼ 1.85 Ma. Alkenone concentrations provide a good proxy for the accumulation of marine organic matter, and primarily reflect regional hydrology. Organic sedimentation, including the formation of layers highly enriched in organic matter ("sapropels") was paced throughout by precessional variations despite changes in both average regional temperature, and the shift in temperature variance to the 41 kyr obliquity cycle in the latest Pliocene and early Pleistocene. Our reconstruction therefore highlights the intermingling of both hemispheric-wide changes in temperature and regional variations in the hydrological cycle that combined to force major evolutionary changes in the fauna and flora of northern Africa and the southern Mediterranean in late Pliocene to mid-Pleistocene time.

  11. High energy astrophysics 21st century workshop 'Space Capabilities in the 21st Century'. [NASA programs

    Science.gov (United States)

    Rhome, Robert C.

    1990-01-01

    An overview of 20th-century NASA accomplishments and of the infrastructure and technology that NASA plans to have in place in the 21st century is presented. Attention is given to the Great Observatories Program, AXAF, the Space Infrared Telescope Facility, the Cosmic Background Explorer, the Small Explorers Program, the Large Area Modular Array of Reflectors, and the X-Ray Background Survey Spectrometer. Also discussed are earth-to-orbit communication links, transportation in the 1990s, the evolution of the space infrastructure, and the Space Station Freedom. Consideration is given to the possibilities of the 21st-century infrastructure, with emphasis on exploration on Mars and the moon. Topics addressed include telecommunications, navigation, information management, and 21st-century space science.

  12. ~100 Ma Lu-Hf eclogite ages from Koralpe and Saualpe (Austroalpine nappes, Austria): New constraints for the kinematics of Eoalpine subduction

    Science.gov (United States)

    Miladinova, Irena; Froitzheim, Nikolaus; Nagel, Thorsten; Janák, Marian; Münker, Carsten

    2016-04-01

    The Koralpe and Saualpe complexes are part of the Austroalpine basement nappe system. They represent the largest region in the Eastern Alps exposing high-pressure metamorphic rocks from the Cretaceous Eoalpine orogenic event and also contain the type locality for eclogite. The grade of the Cretaceous metamorphism in the Eastern Alps increases to the southeast, with maximum pressures and temperatures reaching up to 3.5 GPa and 850 °C in the Pohorje Mountains (Janak et al., 2015). The estimated P-T-conditions for the eclogites from Saualpe and Koralpe are 2-2.2 GPa and 600-740 °C (Miller & Thöni 1997, Thöni et al. 2008). Here we present a new Lu-Hf isotopic study of the eclogites from the Hohl locality in the southern Koralpe, and from the Grünburgerbach and Wolfsberger Hütte localities in the southern Saualpe. Two-point isochrones from samples of Hohl and Wolfsberger Hütte based on one whole rock and one garnet separate yield ages of 99.2 ± 1.1 Ma and 101.7 ± 2 Ma, respectively. Two eclogite samples from Grünburgerbach give garnet-omphacite-whole rock ages of 100.3 ± 1 Ma and 101.79 ± 0.92 Ma, identical within error. The garnets in the eclogite from Hohl display a homogenous composition with no zoning of major elements, whereas the garnets of the samples from Grünburgerbach show an enrichment of Mn in the cores and lower contents towards the rims, which indicates prograde garnet growth during increasing P and T. The ages are therefore related to burial during subduction. These new Lu-Hf garnet ages are slightly older than the Lu-Hf garnet age data from Pohorje (~95 Ma; Sandmann et al. 2011, Thöni et al. 2008), which also date burial. If Koralpe/Saualpe and Pohorje would belong to one continuous crustal unit subducted and exhumed "en bloc" in a southeast-dipping subduction zone, the opposite age difference would be expected. Our results show that this is not the case and represent important constraints for a more realistic kinematic model. Janak, M

  13. SDSS IV MaNGA—Rotation Velocity Lags in the Extraplanar Ionized Gas from MaNGA Observations of Edge-on Galaxies

    International Nuclear Information System (INIS)

    Bizyaev, D.; Pan, K.; Brinkmann, J.; Walterbos, R. A. M.; Yoachim, P.; Riffel, R. A.; Fernández-Trincado, J. G.; Diamond-Stanic, A. M.; Jones, A.; Thomas, D.; Cleary, J.

    2017-01-01

    We present a study of the kinematics of the extraplanar ionized gas around several dozen galaxies observed by the Mapping of Nearby Galaxies at the Apache Point Observatory (MaNGA) survey. We considered a sample of 67 edge-on galaxies out of more than 1400 extragalactic targets observed by MaNGA, in which we found 25 galaxies (or 37%) with regular lagging of the rotation curve at large distances from the galactic midplane. We model the observed H α emission velocity fields in the galaxies, taking projection effects and a simple model for the dust extinction into account. We show that the vertical lag of the rotation curve is necessary in the modeling, and estimate the lag amplitude in the galaxies. We find no correlation between the lag and the star formation rate in the galaxies. At the same time, we report a correlation between the lag and the galactic stellar mass, central stellar velocity dispersion, and axial ratio of the light distribution. These correlations suggest a possible higher ratio of infalling-to-local gas in early-type disk galaxies or a connection between lags and the possible presence of hot gaseous halos, which may be more prevalent in more massive galaxies. These results again demonstrate that observations of extraplanar gas can serve as a potential probe for accretion of gas.

  14. SDSS IV MaNGA—Rotation Velocity Lags in the Extraplanar Ionized Gas from MaNGA Observations of Edge-on Galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Bizyaev, D.; Pan, K.; Brinkmann, J. [Apache Point Observatory and New Mexico State University, Sunspot, NM 88349 (United States); Walterbos, R. A. M. [Department of Astronomy, New Mexico State University, Las Cruces, NM 88003 (United States); Yoachim, P. [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Riffel, R. A. [Departamento de Física, CCNE, Universidade Federal de Santa Maria, Av. Roraima, 1000-97105-900, Santa Maria, RS (Brazil); Fernández-Trincado, J. G. [Institut Utinam, CNRS UMR 6213, Université de Franche-Comté, OSU THETA Franche-Comté-Bourgogne, Observatoire de Besançon, BP 1615, F-25010 Besançon Cedex (France); Diamond-Stanic, A. M. [Department of Astronomy, University of Wisconsin-Madison, Madison, WI 53706 (United States); Jones, A. [Max-Planck Institute for Astrophysics, Karl-Schwarzschild-Str 1, Garching, D-85748 (Germany); Thomas, D. [Institute of Cosmology and Gravitation, University of Portsmouth, Dennis Sciama Building, Portsmouth PO1 3FX (United Kingdom); Cleary, J. [Department of Physics and Astronomy, Johns Hopkins University, Bloomberg Center, 3400 North Charles Street, Baltimore, MD 21218 (United States)

    2017-04-20

    We present a study of the kinematics of the extraplanar ionized gas around several dozen galaxies observed by the Mapping of Nearby Galaxies at the Apache Point Observatory (MaNGA) survey. We considered a sample of 67 edge-on galaxies out of more than 1400 extragalactic targets observed by MaNGA, in which we found 25 galaxies (or 37%) with regular lagging of the rotation curve at large distances from the galactic midplane. We model the observed H α emission velocity fields in the galaxies, taking projection effects and a simple model for the dust extinction into account. We show that the vertical lag of the rotation curve is necessary in the modeling, and estimate the lag amplitude in the galaxies. We find no correlation between the lag and the star formation rate in the galaxies. At the same time, we report a correlation between the lag and the galactic stellar mass, central stellar velocity dispersion, and axial ratio of the light distribution. These correlations suggest a possible higher ratio of infalling-to-local gas in early-type disk galaxies or a connection between lags and the possible presence of hot gaseous halos, which may be more prevalent in more massive galaxies. These results again demonstrate that observations of extraplanar gas can serve as a potential probe for accretion of gas.

  15. Efecto del Extracto de Estigmas de Maíz sobre Aspergillus spp Efecto del Extracto de Estigmas de Maíz sobre Aspergillus spp

    Directory of Open Access Journals (Sweden)

    Hugo Alberto Luna Olvera

    2012-02-01

    Full Text Available Un extracto de estigmas del híbrido de maíz A-791 fue adicionado a un medio de cultivo, evaluándose su efecto sobre el crecimiento, esporulación y síntesis de micotoxinas de Aspergillus parasiticus ATCC 16992 y A. nidulans FGSC-26. Se encontró un efecto estimulatorio en el crecimiento de ambos hongos y la esporulación del primero, contrastado con el efecto inhibitorio en la síntesis de aflatoxinas de A. parasiticus y estimulatorio en la de esterigmatocistina de A. nidulans. Los resultados sugieren la presencia de compuestos en los estigmas frescos del maíz que estimulan el crecimiento y esporulación de A. parasiticus, pero inhiben la síntesis de aflatoxinas.A silk (stigmas extract of hybrid A-791 of maize was added to synthetic culture, evaluating its effect on growth, sporulation and synthesis of micotoxins of Aspergillus parasiticus ATCC 16992 and A. nidulans FGSC-26. It was observed a stimulatory effect in growth of both fungi and sporulation of on the first, contrasting with inhibiting effect in the synthesis of afl atoxins of A. parasiticus and stimulatory in the sterigmatocystin of A. nidulans. Results suggest the presence of compound in stigmas fresh of maize that stimulate the growth and sporulation of A. parasiticus, but inhibit the aflatoxins synthesis.

  16. Tectonically driven late Paleocene (57.9-54.7 Ma) transgression and climatically forced latest middle Eocene (41.3-38.0 Ma) regression on the Indian subcontinent

    Science.gov (United States)

    Singh, B. P.; Singh, Y. Raghumani; Andotra, D. S.; Patra, A.; Srivastava, V. K.; Guruaribam, Venus; Sijagurumayum, Umarani; Singh, G. P.

    2016-01-01

    Cenozoic era was the turning point in the geological history of the Indian subcontinent when India experienced maximum isolation before it collided with Asia and there occurred a great mountain building activity shaping the Himalaya. In the Cenozoic era, the sedimentation commenced in the late Paleocene (∼57.9 Ma) in the pericratonic basins of the western India as well as the foreland basins of the Himalaya that marks the beginning of a major transgression on the Indian subcontinent. Till now, it is not sure whether this transgression was forced by tectonics or climate. We have interpreted that the primary driver for this transgression was the tectonics that marks the beginning of the India-Asia convergence. A major regression of similar magnitude occurred during latest middle Eocene (41.3-38.0 Ma) that corresponds to global sea-level fall. This regression is global and can be identified even in the Cenozoic basins developed within the African plate. It is interpreted that this regression was driven by the global cooling during latest middle Eocene/late Eocene possibly associated with the nucleation of the Antarctica ice-sheets coupled with the uplift of the Himalaya.

  17. SDSS IV MaNGA—Rotation Velocity Lags in the Extraplanar Ionized Gas from MaNGA Observations of Edge-on Galaxies

    Science.gov (United States)

    Bizyaev, D.; Walterbos, R. A. M.; Yoachim, P.; Riffel, R. A.; Fernández-Trincado, J. G.; Pan, K.; Diamond-Stanic, A. M.; Jones, A.; Thomas, D.; Cleary, J.; Brinkmann, J.

    2017-04-01

    We present a study of the kinematics of the extraplanar ionized gas around several dozen galaxies observed by the Mapping of Nearby Galaxies at the Apache Point Observatory (MaNGA) survey. We considered a sample of 67 edge-on galaxies out of more than 1400 extragalactic targets observed by MaNGA, in which we found 25 galaxies (or 37%) with regular lagging of the rotation curve at large distances from the galactic midplane. We model the observed Hα emission velocity fields in the galaxies, taking projection effects and a simple model for the dust extinction into account. We show that the vertical lag of the rotation curve is necessary in the modeling, and estimate the lag amplitude in the galaxies. We find no correlation between the lag and the star formation rate in the galaxies. At the same time, we report a correlation between the lag and the galactic stellar mass, central stellar velocity dispersion, and axial ratio of the light distribution. These correlations suggest a possible higher ratio of infalling-to-local gas in early-type disk galaxies or a connection between lags and the possible presence of hot gaseous halos, which may be more prevalent in more massive galaxies. These results again demonstrate that observations of extraplanar gas can serve as a potential probe for accretion of gas.

  18. REGENERASI DAN PERBANYAKAN RUMPUT LAUT Kappaphycus alvarezii HASIL TRANSFORMASI GEN SUPEROKSIDA DISMUTASE (MaSOD

    Directory of Open Access Journals (Sweden)

    Emma Suryati

    2017-01-01

    Full Text Available Transformasi gen superoxide dismutase (MaSOD pada rumput laut Kappaphycus alvarezii menggunakan Agrobacterium tumefacient telah dilakukan secara in vitro. Transformasi gen MaSOD ke dalam genom rumput laut diharapkan dapat mengurangi cekaman oksidatif terutama yang disebabkan oleh perubahan suhu, salinitas, dan cemaran logam di perairan. Penelitian ini bertujuan untuk regenerasi rumput laut hasil introduksi gen MaSOD dan non-transgenik pada labu kultur. Regenerasi dan perbanyakan rumput laut hasil transformasi gen MaSOD dilakukan di laboratorium pada labu kultur yang diletakkan dalam “culture chamber” yang dilengkapi dengan aerasi menggunakan media kultur yang diperkaya dengan pupuk PES, Grund, Conwy, dan SSW sebagai kontrol, salinitas 20, 25, 30, 35, dan 40 g/L, pH 4, 5, 6, 7, dan 8. Intensitas cahaya antara 500-2.000 lux dengan fotoperiode terang dan gelap 8:16; 12:12; dan 16:8. Untuk merangsang pertumbuhan eksplan dilakukan pemeliharaan dengan penambahan hormon tumbuh IAA dan BAP dengan perbandingan 1:1, 1:2, dan 2:1. Penelitian dilakukan secara bertahap. Evaluasi transgenik dilakukan menggunakan teknik PCR. Hasil penelitian memperlihatkan bahwa sintasan yang paling tinggi diperoleh menggunakan media PES (94%, salinitas 30 g/L (90%, pH 7 (96%, intensitas cahaya pada 1.500 lux (80%, fotoperiode 12:12 (84%, komposisi ZPT dengan campuran IAA dan BAP dengan perbandingan 2:1. Hasil analisis PCR memperlihatkan K. alvarezii transgenik putatif mengandung transgen MaSOD sebanyak 78% dari hasil transformasi. Superoxide dismutase transformation (MaSOD gene of seaweed Kappaphycus alvarezii mediated by Agrobacterium tumefacient has been successfully done in vitro. MaSOD genes introduced into the seaweed genome is expected to reduce oxidative stress caused by environmental conditions such as changes in temperature, salinity and metal contamination of the water. This study aimed to regenerate both the MaSOD transformed seaweed and non-transgenic in a

  19. Supplement Analysis for the Transmission System Vegetation Management Program FEIS (DOE/EIS-0285/SA-56)

    Energy Technology Data Exchange (ETDEWEB)

    Stratton, Elaine [Bonneville Power Administration (BPA), Portland, OR (United States)

    2002-04-09

    Vegetation Management for the following electric yards located in the Ross District: Cape Horn, North Bonneville, Stevenson, Carson, Underwood, Troutdale, Cascade Locks, Acton Ross 345 kilovolts and J.D., Alcoa, Sifton, St. Johns, Ostrander, McLoughlin. BPA proposes to maintain a weed-free environment in the electrical substations located within the Olympia Region’s Ross District.

  20. The International Diversification of Banks and the Value of their Cross-Border M&A Advice

    NARCIS (Netherlands)

    de Jong, A.; Ongena, S.; van der Poel, M.

    2010-01-01

    This paper investigates the effects of international diversification of banks on the value of their M&A advice. We study bidder returns to 1,253 cross-border M&A announcements. We find that acquirers engaging a more internationally diversified financial advisor generate lower excess returns.

  1. NuMA in rat testis--evidence for roles in proliferative activity and meiotic cell division.

    Science.gov (United States)

    Taimen, Pekka; Parvinen, Martti; Osborn, Mary; Kallajoki, Markku

    2004-08-15

    NuMA is a well-characterized organizer of the mitotic spindle, which is believed to play a structural role in interphase nucleus. We studied the expression of NuMA in rat seminiferous epithelium in detail. Different stages of the cycle of the seminiferous epithelium were identified using transillumination. Corresponding areas were microdissected and analysed using immunofluorescence, immunohistochemistry, or immunoblotting. NuMA was expressed in Sertoli cells, proliferating type A and B spermatogonia, and early spermatids but it was absent in late spermatids and mature spermatozoa. Interestingly, NuMA-positive primary spermatocytes lost their nuclear NuMA at the beginning of long-lasting prophase of the first meiotic division. A strong expression was again observed at the end of the prophase and finally, a redistribution of NuMA into pole regions of the meiotic spindle was observed in first and second meiotic divisions. In immunoblotting, a single 250-kDa protein present in all stages of the rat seminiferous epithelial cycle was detected. Our results show that NuMA is not essential for the organization of nuclear structure in all cell types and suggest that its presence is more likely connected to the proliferation phase of the cells. They also suggest that NuMA may play an important role in meiotic cell division.

  2. Aeolian and fluviolacustrine landforms and prehistoric human occupation on a tectonically influenced floodplain margin, the Méma, central Mali

    Science.gov (United States)

    B. Makaske; E. De Vries; J. A. Tainter; R. J. McIntosh

    2007-01-01

    The Méma is a semi-arid region in central Mali with a rich archaeological heritage indicating the former existence of large urban settlements. The archaeological data suggest millennia of occupation history of the Méma preceding relatively sudden abandonment by the 14th or 15th century AD. Population numbers have remained low since then and today...

  3. 46 CFR 7.20 - Nantucket Sound, Vineyard Sound, Buzzards Bay, Narragansett Bay, MA, Block Island Sound and...

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Nantucket Sound, Vineyard Sound, Buzzards Bay, Narragansett Bay, MA, Block Island Sound and easterly entrance to Long Island Sound, NY. 7.20 Section 7.20... Atlantic Coast § 7.20 Nantucket Sound, Vineyard Sound, Buzzards Bay, Narragansett Bay, MA, Block Island...

  4. Aeolian and fluviolacustrine landforms and prehistoric human occupation on a tectonically influenced floodplain margin, the Méma, central Mali

    NARCIS (Netherlands)

    Makaske, B.; Vries, de E.; Tainter, J.A.; McIntosh, R.J.

    2007-01-01

    The Méma is a semi-arid region in central Mali with a rich archaeological heritage indicating the former existence of large urban settlements. The archaeological data suggest millennia of occupation history of the Méma preceding relatively sudden abandonment by the 14th or 15th century AD.

  5. 78 FR 7439 - Proposed Alterations to Pawtucket Dam on the Merrimack River in Lowell, MA; Public Meeting

    Science.gov (United States)

    2013-02-01

    ... PRESERVATION Proposed Alterations to Pawtucket Dam on the Merrimack River in Lowell, MA; Public Meeting AGENCY..., regarding proposed alterations to Pawtucket Dam on the Merrimack River in Lowell, MA. SUMMARY: The Federal... consulting parties, and notifying the public. Priority for speaking at the public meeting will be given to...

  6. Overview of the SDSS-IV MaNGA Survey: Mapping nearby Galaxies at Apache Point Observatory

    NARCIS (Netherlands)

    Bundy, Kevin; Bershady, Matthew A.; Law, David R.; Yan, Renbin; Drory, Niv; MacDonald, Nicholas; Wake, David A.; Cherinka, Brian; Sánchez-Gallego, José R.; Weijmans, Anne-Marie; Thomas, Daniel; Tremonti, Christy; Masters, Karen; Coccato, Lodovico; Diamond-Stanic, Aleksandar M.; Aragón-Salamanca, Alfonso; Avila-Reese, Vladimir; Badenes, Carles; Falcón-Barroso, Jésus; Belfiore, Francesco; Bizyaev, Dmitry; Blanc, Guillermo A.; Bland-Hawthorn, Joss; Blanton, Michael R.; Brownstein, Joel R.; Byler, Nell; Cappellari, Michele; Conroy, Charlie; Dutton, Aaron A.; Emsellem, Eric; Etherington, James; Frinchaboy, Peter M.; Fu, Hai; Gunn, James E.; Harding, Paul; Johnston, Evelyn J.; Kauffmann, Guinevere; Kinemuchi, Karen; Klaene, Mark A.; Knapen, Johan H.; Leauthaud, Alexie; Li, Cheng; Lin, Lihwai; Maiolino, Roberto; Malanushenko, Viktor; Malanushenko, Elena; Mao, Shude; Maraston, Claudia; McDermid, Richard M.; Merrifield, Michael R.; Nichol, Robert C.; Oravetz, Daniel; Pan, Kaike; Parejko, John K.; Sanchez, Sebastian F.; Schlegel, David; Simmons, Audrey; Steele, Oliver; Steinmetz, Matthias; Thanjavur, Karun; Thompson, Benjamin A.; Tinker, Jeremy L.; van den Bosch, Remco C. E.; Westfall, Kyle B.; Wilkinson, David; Wright, Shelley; Xiao, Ting; Zhang, Kai

    We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic

  7. Managing Reliability in the 21st Century

    Energy Technology Data Exchange (ETDEWEB)

    Dellin, T.A.

    1998-11-23

    The rapid pace of change at Ike end of the 20th Century should continue unabated well into the 21st Century. The driver will be the marketplace imperative of "faster, better, cheaper." This imperative has already stimulated a revolution-in-engineering in design and manufacturing. In contrast, to date, reliability engineering has not undergone a similar level of change. It is critical that we implement a corresponding revolution-in-reliability-engineering as we enter the new millennium. If we are still using 20th Century reliability approaches in the 21st Century, then reliability issues will be the limiting factor in faster, better, and cheaper. At the heart of this reliability revolution will be a science-based approach to reliability engineering. Science-based reliability will enable building-in reliability, application-specific products, virtual qualification, and predictive maintenance. The purpose of this paper is to stimulate a dialogue on the future of reliability engineering. We will try to gaze into the crystal ball and predict some key issues that will drive reliability programs in the new millennium. In the 21st Century, we will demand more of our reliability programs. We will need the ability to make accurate reliability predictions that will enable optimizing cost, performance and time-to-market to meet the needs of every market segment. We will require that all of these new capabilities be in place prior to the stint of a product development cycle. The management of reliability programs will be driven by quantifiable metrics of value added to the organization business objectives.

  8. Synkinematic(?) intrusion of the ``anorogenic'' 1425 Ma Beer Bottle Pass pluton, southern Nevada

    Science.gov (United States)

    Duebendorfer, Ernest M.; Christensen, Clint

    1995-02-01

    The tectonic setting of a transcontinental belt of 1500-1300 Ma granitic intrusions that extends from southern California to Labrador is controversial; however, the granites are conventionally considered to be "anorogenic." Detailed field, microstructural, and geochronologic data from the 1425 Ma Beer Bottle Pass pluton, southern Nevada, indicate that major mylonite zones recording dextral-contractile strains were probably active during and/or shortly after pluton emplacement and suggest that the anorogenic interpretation for this pluton requires reevaluation. Mylonite zones up to 100 m thick strike northeast, dip moderately northwest, and contain a consistent west plunging elongation lineation. Mylonites occur along 15% of the exposed granite-wall rock contact and extend into both the pluton and the wall rock. Mesoscopic and microscopic kinematic indicators record an oblique, dextral/reverse (pluton side down) movement sense. Synkinematic mineral assemblages of hornblende and biotite and dynamic recrystallization of feldspars suggest that deformation occurred minimally under amphibolite facies conditions. A K/Ar biotite date of 1399±32 Ma, obtained from a sample of mylonitic granite, suggests that deformation took place during or soon following pluton crystallization. We reject forcible emplacement of the Beer Bottle Pass pluton as a mechanism for formation of the mylonite zones because (1) rocks near the granite-wall rock contact are largely unstrained, (2) the mylonite zones conform only locally to the pluton-wall rock contact, (3) mylonite zones strike at high angles to, and truncate, the intrusive pluton-wall rock contact, (4) the pluton-side-down shear sense is more compatible with a uniform sense simple shear zone than a forcibly intruding pluton, and (5) fabrics indicative of noncoaxial deformation dominate over flattening fabrics. We suggest that the Beer Bottle Pass pluton is fundamentally synkinematic with respect to either (1) a local, contractile

  9. The medical theory of Lee Je-ma and its character

    Directory of Open Access Journals (Sweden)

    LEE Kyung-Lock

    2005-12-01

    Full Text Available Lee Je-ma(李濟馬, 1837-1900 was a prominent scholar as well as an Korean physician He classified every people into four distinctive types: greater yang[tai yang] person, lesser yin[shao yin] person greater yin[tai yin] person, lesser yin[shao yin] person. This theory would dictate proper treatment for each type in accordance with individual differences of physical and temperament features Using these four types he created The Medical Science of Four Types(四象體質論.This article is intended to look into the connection between Lee Je-Ma's 'The Medical Science of Four Types' and 'The Modern' with organizing his ideas about the human body and the human being. Through The Modern, the theory of human being(人間觀 underwent a complete change. Human being in The Premodern, which was determined by sex, age and social status has been changed to the individual human being, which is featured by equality. Lee Je-Ma's medical theory of The Medical Science of Four Types would be analyzed as follow. His concept of human body(人體論 is oriented toward observable objectivity. But on the other hand, it still remains transcendent status of medical science, which is subordinated by philosophy According to Lee Je-Ma's theory of human being human is an equal individual in a modern way of thinking not as a part of hierarchical group. But on the other hand, it still remains incomplete from getting rid of morality aspect that includes virtue and vice in the concept of human body.The common factors in Lee Je-Ma's ideas about the human body and the human being is 'Dualism of mind and body(心身二元論' that means all kinds of status and results depends on each individual. As is stated above, Lee Je-Ma's medical theory has many aspects of The Modern and it proves that Korean traditional medicine could be modernized by itself.

  10. MA Doping Analysis on Breeding Capability and Protected Plutonium Production of Large FBR

    Science.gov (United States)

    Permana, Sidik; Suzuki, Mitsutoshi; Kuno, Yusuke

    2010-06-01

    Spent fuel from LWR can be seen as long-live waste if it is not recycled or as a "new fuel" resource if it is recycled into the reactors. Uranium and plutonium have been used for "new fuel" resources from LWR spent fuel as MOX fuel type which is loaded into thermal reactor or fast reactor types. Other actinides from the spent fuel such as neptunium, americium and curium as minor actinide (MA) are considered to be loaded into the reactors for specific purposes, recently. Those purposes such as for increasing protected plutonium production and breeding capability for protected plutonium as well as in the same time those amount of MA can be reduced to a small quantity as a burner or transmutation purpose. Some investigations and scientific approaches are performed in order to increase a material "barrier" in plutonium isotope composition by increasing the even mass number of plutonium isotope such as Pu-238, Pu-240 and Pu-242 as plutonium protected composition. Higher material barrier which related to intrinsic properties of plutonium isotopes with even mass number (Pu-238, Pu-240 and Pu-242), are recognized because of their intense decay heat (DH) and high spontaneous fission neutron (SFN) rates. Those even number mass of plutonium isotope contribute to some criteria of plutonium characterization which will be adopted for present study such as IAEA, Pellaud and Kessler criteria (IAEA, 1972; Pellaud, 2002; and Kessler, 2007). The present paper intends to evaluate the breeding capability as a fuel sustainability index of the reactors and to analyze the composition of protected plutonium production of large power reactor based on the FaCT FBR as reference (Ohki, et al., 2008). Three dimensional FBR core configuration has been adopted which is based on the core optimization calculation of SRAC-CITATION code as reactor core analysis and JENDL-3.3 is adopted for nuclear data library. Some MA doping materials are loaded into the blanket regions which can be considered as

  11. ST-elevations-myokardieinfarkt efter terapeutisk adrenalininjektion

    DEFF Research Database (Denmark)

    Rømhild Davidsen, Jesper; Lambrechtsen, Jess; Egstrup, Kenneth

    2006-01-01

    A case of acute myocardial infarction (AMI) following accidental iatrogenic overdose by adrenaline injection is described in a male aged 55 years. This patient was given 1 mg of adrenaline due to anaphylactic symptoms. Afterwards he presented with angina pectoris, dyspnoea and ST-segment elevation...... in the ECG. Plasma TnT and CK-MB were raised. A coronary angiography revealed a 66% stenosis of RCA. This patient had an asymptomatic RCA stenosis that probably became symptomatic due to coronary artery spasm related to adrenaline injection and thereby presented symptoms and signs of AMI....

  12. Water resources of St. Charles Parish, Louisiana

    Science.gov (United States)

    White, Vincent E.; Prakken, Lawrence B.

    2015-01-01

    Information concerning the availability, use, and quality of water in St. Charles Parish, Louisiana, is critical for proper water-supply management. The purpose of this fact sheet is to present information that can be used by water managers, parish residents, and others for stewardship of this vital resource. Information on the availability, past and current use, use trends, and water quality from groundwater and surface-water sources in the parish is presented. Previously published reports and data stored in the U.S. Geological Survey’s National Water Information System (http://waterdata.usgs.gov/nwis) are the primary sources of the information presented here.

  13. Water resources of St. James Parish, Louisiana

    Science.gov (United States)

    White, Vincent E.; Prakken, Lawrence B.

    2015-01-01

    Information concerning the availability, use, and quality of water in St. James Parish, Louisiana, is critical for proper water-supply management. The purpose of this fact sheet is to present information that can be used by water managers, parish residents, and others for stewardship of this vital resource. Information on the availability, past and current use, use trends, and water quality from groundwater and surface-water sources in the parish is presented. Previously published reports and data stored in the U.S. Geological Survey’s National Water Information System (http://waterdata.usgs.gov/nwis) are the primary sources of the information presented here.

  14. 31st IMAC Conference on Structural Dynamics

    CERN Document Server

    Adams, Douglas; Carrella, Alex; Mayes, Randy; Rixen, Daniel; Allen, Matt; Cunha, Alvaro; Catbas, Fikret; Pakzad, Shamim; Racic, Vitomir; Pavic, Aleksandar; Reynolds, Paul; Simmermacher, Todd; Cogan, Scott; Moaveni, Babak; Papadimitriou, Costas; Allemang, Randall; Clerck, James; Niezrecki, Christopher; Wicks, Alfred

    2013-01-01

    Topics in Nonlinear Dynamics, Volume 1: Proceedings of the 31st IMAC, A Conference and Exposition on Structural Dynamics, 2013, the first volume of seven from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Structural Dynamics, including papers on:   Nonlinear Oscillations Nonlinearities In Practice Nonlinear System Identification: Methods Nonlinear System Identification: Friction & Contact Nonlinear Modal Analysis Nonlinear Modeling & Simulation Nonlinear Vibration Absorbers Constructive Utilization of Nonlinearity.

  15. Nuclear regulatory legislation, 101st Congress

    International Nuclear Information System (INIS)

    1991-06-01

    This document is a compilation of nuclear regulatory legislation and other relevant material through the 101st Congress, 2nd Session. This compilation has been prepared for use as a resource document, which the NRC intends to update at the end of every Congress. The contents of NUREG-0980 include The Atomic Energy Act of 1954, as amended: Energy Reorganization Act of 1974, as amended; Uranium Mill Tailings Radiation Control Act of 1978; Low-Level Radioactive Waste Policy Act; Nuclear Waste Policy Act of 1982; and NRC Authorization and Appropriations Acts. Other materials included are statues and treaties on export licensing, nuclear non-proliferation, and environmental protection

  16. Health Physics in the 21st Century

    CERN Document Server

    Bevelacqua, Joseph John

    2008-01-01

    Adopting a proactive approach and focusing on emerging radiation-generating technologies, Health Physics in the 21st Century meets the growing need for a presentation of the relevant radiological characteristics and hazards. As such, this monograph discusses those technologies that will affect the health physics and radiation protection profession over the decades to come. After an introductory overview, the second part of this book looks at fission and fusion energy, followed by a section devoted to accelerators, while the final main section deals with radiation on manned space missions.

  17. 21st Century South African Science Fiction

    Directory of Open Access Journals (Sweden)

    CARAIVAN LUIZA

    2014-12-01

    Full Text Available The paper analyses some aspects of South African science fiction, starting with its beginnings in the 1920s and focusing on some 21st century writings. Thus Lauren Beukes’ novels Moxyland (2008 and Zoo City (2010 are taken into consideration in order to present new trends in South African literature and the way science fiction has been marked by Apartheid. The second South African science fiction writer whose writings are examined is Henrietta Rose-Innes (with her novel Nineveh, published in 2011 as this consolidates women's presence in the SF world.

  18. Diversidad genética en el patosistema maíz-fusarium en el Altiplano de México.

    OpenAIRE

    Briones Reyes, Dolores

    2014-01-01

    Las variantes de maíz (Zea mays L.) nativas (criollos) preservadas por los agricultores a través de generaciones, constituyen más de 80% del área sembrada con maíz en México; la pudrición de mazorca por Fusarium spp. provoca pérdidas de hasta 30%. El estudio de las poblaciones de maíz y sus patógenos como patosistema tiene sentido, pues en la variación genética del maíz nativo se puede encontrar resistencia/tolerancia a enfermedades; el conocimiento de la estructura de las poblaciones de maíz...

  19. Principal Component Surface (2011) for St. Thomas East End Reserve, St. Thomas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.3x0.3 meter principal component analysis (PCA) surface for areas the St. Thomas East End Reserve (STEER) in the U.S. Virgin Islands (USVI)....

  20. Gilles Mouëllic, Jazz et cinéma

    OpenAIRE

    Meyran, Régis

    2007-01-01

    Jazz et cinéma se compose de deux parties : la première offre un historique fort bien documenté sur les rapports entre le cinéma et le jazz ; la seconde ressemble davantage à un essai comparant la part d’improvisation dans les deux domaines, mais, à partir de là, l’interprétation très libre de l’auteur ne convainc pas totalement. Je m’expliquerai plus loin sur ce point et tenterai tout d’abord de résumer le contenu de l’ouvrage. Il existe dès le début d’indéniables traits communs entre le jaz...

  1. Izsoļu sistēma uz satvara “Laravel”

    OpenAIRE

    Kasparsons, Reinis

    2015-01-01

    Darbā aprakstīta informācijas sistēma, kas paredzēta uzņēmumam, kuram nepieciešama vienkārša izsoļu sistēma pakalpojumu un preču izsolei. Sistēmas klientiem tā nodrošina produkta iegādes iespēju, bet pārdevējam savu produktu un pakalpojumu vienkāršu izsoli. Sistēmas realizācija datu glabāšanai izmanto datubāzi ar SQL pieeju. Lietotāju skati tiek veidoti, izmantojot PHP, HTML5,CSS3,Bootstrap un Laravel.

  2. A high-resolution model for Eurasia-North America plate kinematics since 20 Ma

    Science.gov (United States)

    Merkouriev, S.; DeMets, C.

    2008-06-01

    We derive the first chronologically detailed model of Eurasia-North America plate motion since 20 Ma from ship and airplane surveys of the well-expressed magnetic lineations along this slowly spreading plate boundary, including previously unavailable dense Russian magnetic data from the southern Reykjanes Ridge and northern Mid-Atlantic ridge near the Charlie Gibbs fracture zone. From more than 7000 crossings of 21 magnetic anomalies from Anomaly 1n (0.78 Ma) to Anomaly 6n (19.7 Ma), we estimate best-fitting finite rotations and realistic uncertainties. Linear regressions of total opening distances versus their reversal ages at different locations along the plate boundary show that reversal boundaries are shifted systematically outwards from the spreading axis with respect to their idealized locations, with the outward shift ranging from more than 5 km between Iceland and the Charlie Gibbs fracture zone to ~2 km elsewhere. This outward displacement, which is a consequence of the finite zone of seafloor accretion, degrades estimates of the underlying plate motion and is thus removed for the ensuing kinematic analysis. The corrected plate motion rotations reveal surprising, previously unrecognized features in the relative motions of these two plates. Within the uncertainties, motion was steady from 20 to 8 Ma around a pole that was located ~600 km north of the present pole, with seafloor spreading rates that changed by no more than 5 per cent (1 mm yr-1) along the Reykjanes Ridge during this period. Seafloor spreading rates decreased abruptly by 20 +/- 2 per cent at 7.5-6.5 Ma, coinciding with rapid southward migration of the pole of rotation and a 5°-10° counter-clockwise change in the plate slip direction. Eurasia-North America plate motion since 6.7 Ma has remained remarkably steady, with an apparently stationary axis of rotation and upper limit of +/-2 per cent on any variations in the rate of angular rotation during this period. Based on the good agreement

  3. PERENCANAAN PEMANFAATAN MARINE FUEL OIL (MFO SEBAGAI BAHAN BAKAR ENGINE DIESEL MaK

    Directory of Open Access Journals (Sweden)

    Hendra Poeswanto

    2015-06-01

    Full Text Available PT. PLN (Persero Area Bontang tengah berupaya melakukan penggantian jenis bahan bakar pada engine diesel merk MaK yang semula menggunakan High Speed Diesel (HSD menjadi Marine Fuel Oil (MFO. Tujuan penelitian ini untuk mengetahui proses treatment bahan bakar MFO untuk menurunkan viscositas dan penyeragaman ukuran partikel bahan bakar pada engine diesel merk MaK dan mengetahui perbandingan biaya penghematan dan evisiensi pemakaian bahan bakar HSD dengan bahan bakar MFO. Metode yang digunakan analisa perpindaahan panas pada oil heater dan viskositas bahan bakar yang digunakan untuk menentukan proses treatment bahan bakar MFO. Dari hasil perencanaan, proses treatment menggunakan oli heater dimana proses pemanasan oli dengan memanfaatkan panas dari gas buang hasil pembakaran. Dengan penggunaan bahan bakar MFO dapat menghemat biaya konsumsi bahan bakar sebesar Rp. 21.827.520,- per harinya.

  4. MaMiCo: Software design for parallel molecular-continuum flow simulations

    KAUST Repository

    Neumann, Philipp

    2015-11-19

    The macro-micro-coupling tool (MaMiCo) was developed to ease the development of and modularize molecular-continuum simulations, retaining sequential and parallel performance. We demonstrate the functionality and performance of MaMiCo by coupling the spatially adaptive Lattice Boltzmann framework waLBerla with four molecular dynamics (MD) codes: the light-weight Lennard-Jones-based implementation SimpleMD, the node-level optimized software ls1 mardyn, and the community codes ESPResSo and LAMMPS. We detail interface implementations to connect each solver with MaMiCo. The coupling for each waLBerla-MD setup is validated in three-dimensional channel flow simulations which are solved by means of a state-based coupling method. We provide sequential and strong scaling measurements for the four molecular-continuum simulations. The overhead of MaMiCo is found to come at 10%-20% of the total (MD) runtime. The measurements further show that scalability of the hybrid simulations is reached on up to 500 Intel SandyBridge, and more than 1000 AMD Bulldozer compute cores. Program summary: Program title: MaMiCo. Catalogue identifier: AEYW_v1_0. Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEYW_v1_0.html Program obtainable from: CPC Program Library, Queen\\'s University, Belfast, N. Ireland. Licensing provisions: BSD License. No. of lines in distributed program, including test data, etc.: 67905. No. of bytes in distributed program, including test data, etc.: 1757334. Distribution format: tar.gz. Programming language: C, C++II. Computer: Standard PCs, compute clusters. Operating system: Unix/Linux. RAM: Test cases consume ca. 30-50 MB. Classification: 7.7. External routines: Scons (http:www.scons.org), ESPResSo, LAMMPS, ls1 mardyn, waLBerla. Nature of problem: Coupled molecular-continuum simulation for multi-resolution fluid dynamics: parts of the domain are resolved by molecular dynamics whereas large parts are covered by a CFD solver, e.g. a lattice Boltzmann automaton

  5. Nancy Berthier (dir., Le cinéma d´Alejandro Amenábar

    Directory of Open Access Journals (Sweden)

    Ana Recalde Delgado

    2010-01-01

    Full Text Available Cet ouvrage, auquel participent Jean-Paul Aubert, Elisa Costa, Françoise Heitz, Aurélie Ledoux, Jacques Terrasa et Pascale Thibaudeau, est coordonné par Nancy Berthier (Université Paris-Est, chercheuse passionnée du cinéma espagnol, qui a publié notamment Le franquisme et son image (1998, De la guerre à l´écran. ¡Ay Carmela! De Carlos Saura (1999 ou Le cinéma de Bigas Luna (2000. Le réalisateur qui fait l’objet de ce travail est le Chileno-Espagnol Alejandro Amenábar, jeune auteur de quat...

  6. Sociologie et cinéma : vers l’hybridation ?

    Directory of Open Access Journals (Sweden)

    2012-12-01

    Full Text Available Pourquoi une rubrique « Champs et contrechamps » dans une revue de Sociologie du Travail ? La raison d’être de cette rubrique est de participer à l’émergence de la Sociologie visuelle et filmique en tant que combinaison ou hybridation du cinéma et de la sociologie. Ce programme sera largement explicité ci-dessous et dans les futurs numéros de la revue. Il s’agit de favoriser la compréhension réciproque par les lecteurs de deux mondes qui se sont longtemps ignorés. Cinéma et sociologie repose...

  7. A comparative study of the corrosion resistance of incoloy MA 956 and PM 2000 superalloys

    Directory of Open Access Journals (Sweden)

    Maysa Terada

    2010-12-01

    Full Text Available Austenitic stainless steels, titanium and cobalt alloys are widely used as biomaterials. However, new medical devices require innovative materials with specific properties, depending on their application. The magnetic properties are among the properties of interest for some biomedical applications. However, due to the interaction of magnetic materials with Magnetic Resonance Image equipments they might used only as not fixed implants or for medical devices. The ferromagnetic superalloys, Incoloy MA 956 and PM 2000, produced by mechanical alloying, have similar chemical composition, high corrosion resistance and are used in high temperature applications. In this study, the corrosion resistance of these two ferritic superalloys was compared in a phosphate buffer solution. The electrochemical results showed that both superalloys are passive in this solution and the PM 2000 present a more protective passive film on it associated to higher impedances than the MA 956.

  8. La maîtrise du temps comme enjeu de lutte

    OpenAIRE

    Bureau, Marie-Christine; Corsani, Antonella

    2012-01-01

    Le conflit social autour de la réforme du régime d'assurance chômage des intermittents du spectacle a été marqué par son intensité et par sa durée. La thèse défendue ici est que la maîtrise du temps constitue l’un des enjeux majeurs de ce conflit. L'affrontement sur le terrain économique de la régulation de l'emploi et de l'industrie culturelle s'est doublé de l'affrontement sur le temps. La question du temps ne se limite pas à la régulation du temps de travail, elle concerne la maîtrise du t...

  9. MaMiCo: Transient multi-instance molecular-continuum flow simulation on supercomputers

    Science.gov (United States)

    Neumann, Philipp; Bian, Xin

    2017-11-01

    We present extensions of the macro-micro-coupling tool MaMiCo, which was designed to couple continuum fluid dynamics solvers with discrete particle dynamics. To enable local extraction of smooth flow field quantities especially on rather short time scales, sampling over an ensemble of molecular dynamics simulations is introduced. We provide details on these extensions including the transient coupling algorithm, open boundary forcing, and multi-instance sampling. Furthermore, we validate the coupling in Couette flow using different particle simulation software packages and particle models, i.e. molecular dynamics and dissipative particle dynamics. Finally, we demonstrate the parallel scalability of the molecular-continuum simulations by using up to 65 536 compute cores of the supercomputer Shaheen II located at KAUST. Program Files doi:http://dx.doi.org/10.17632/w7rgdrhb85.1 Licensing provisions: BSD 3-clause Programming language: C, C++ External routines/libraries: For compiling: SCons, MPI (optional) Subprograms used: ESPResSo, LAMMPS, ls1 mardyn, waLBerla For installation procedures of the MaMiCo interfaces, see the README files in the respective code directories located in coupling/interface/impl. Journal reference of previous version: P. Neumann, H. Flohr, R. Arora, P. Jarmatz, N. Tchipev, H.-J. Bungartz. MaMiCo: Software design for parallel molecular-continuum flow simulations, Computer Physics Communications 200: 324-335, 2016 Does the new version supersede the previous version?: Yes. The functionality of the previous version is completely retained in the new version. Nature of problem: Coupled molecular-continuum simulation for multi-resolution fluid dynamics: parts of the domain are resolved by molecular dynamics or another particle-based solver whereas large parts are covered by a mesh-based CFD solver, e.g. a lattice Boltzmann automaton. Solution method: We couple existing MD and CFD solvers via MaMiCo (macro-micro coupling tool). Data exchange and

  10. Mechanical properties of biocompatible clay/P(MEO2MA-co-OEGMA) nanocomposite hydrogels.

    Science.gov (United States)

    Xiang, Hengxue; Xia, Mengge; Cunningham, Alexander; Chen, Wei; Sun, Bin; Zhu, Meifang

    2017-08-01

    The effects of crosslinking density, polymer concentration and monomer ratio on the mechanical properties (tensile and compressive properties) of biocompatible clay/P(MEO 2 MA-co-OEGMA) nanocomposite (NC) hydrogels were investigated. These novel NC hydrogels, composed of inorganic/organic networks, were prepared via in-situ free radical polymerization. The results showed that with increasing inorganic crosslinking agent, i.e. clay concentration, an increase in the tensile strength, elongation at break and compressive strength was observed. Similarly, with increasing polymer concentration, the tensile strength and compressive strength of the NC hydrogels increased while the elongation at break decreased. Increasing the molar concentration of OEGMA in the comonomer led to an increase in the tensile strength of the NC hydrogels but a reduction in the compressive strength. Moreover, clay/P(MEO 2 MA-co-OEGMA) NC hydrogels presented good biocompatibility bolstering their application as tissue engineering scaffolds. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. M&A flows and the foreign exchange markets:practical experiences

    Directory of Open Access Journals (Sweden)

    Martijn A. Schrijvers

    2002-03-01

    Full Text Available The large cross-border Merger and Acquisition flows of the last three years were seen by financial markets as one of the factors behind movements in exchange rates. However, the extent to which an M&A-transaction actually leads to a foreignexchange transaction is dependent on the financing and transaction techniques used and is difficult to measure. In this article, we analyse which considerations underlie the decisions of corporate Treasurers regarding the financing of take-overs and the techniques to be used by forex transactions. We investigate the effect Treasurers believe M&A transactions have on exchange rates and examine whether different techniques make for different effects. The information was obtained through interviews with Treasurers of multinationals conducting large-scale M&A activities.

  12. Demanda de tortilla de maíz en México, 1996-2008.

    OpenAIRE

    Retes Mantilla, Rogel Fernando

    2011-01-01

    La tortilla de maíz (Zea mays L.) es un alimento fundamental en la dieta de los mexicanos ya que representa el 38.8 % de las proteínas, 45.2 % de las calorías y 49.1 % del calcio de su ingesta diaria. Sin embargo, su demanda disminuyó 36.7 % de 1996 a 2008. Por lo que, el presente trabajo tuvo como objetivo identificar los principales factores económicos que determinan el comportamiento de la demanda de tortilla de maíz en México por estratos de ingreso y medir el orden de magnitud en que dic...

  13. Tensile and fracture toughness properties of MA957: implications to the development of nanocomposited ferritic alloys

    International Nuclear Information System (INIS)

    Alinger, M.J.; Odette, G.R.; Lucas, G.E.

    2002-01-01

    A study to explore approaches to optimizing nanocomposited ferritic alloys was carried out on dispersion strengthened mechanically alloyed (MA) MA957, in the form of extruded bar stock. Previous studies had indicated that this alloy manifested superior high temperature strength and radiation stability, but was extremely brittle in notch impact tests. Thus our objective was to develop a combination of tensile, fracture toughness and microstructural data to clarify the basis for this brittle behavior. To this end, tensile properties and fracture toughness were characterized as a function of temperature in various orientations relative to the grain and inclusion structures. This database along with extensive fractography suggests that brittleness is due to the presence of a large volume fraction of impurity alumina stringers. In orientations where the effects of the stringers are reduced, much higher toughness was observed. These results provide a path for alloy development approach to achieve high strength and toughness

  14. Tensile and fracture toughness properties of MA957: implications to the development of nanocomposited ferritic alloys

    Science.gov (United States)

    Alinger, M. J.; Odette, G. R.; Lucas, G. E.

    2002-12-01

    A study to explore approaches to optimizing nanocomposited ferritic alloys was carried out on dispersion strengthened mechanically alloyed (MA) MA957, in the form of extruded bar stock. Previous studies had indicated that this alloy manifested superior high temperature strength and radiation stability, but was extremely brittle in notch impact tests. Thus our objective was to develop a combination of tensile, fracture toughness and microstructural data to clarify the basis for this brittle behavior. To this end, tensile properties and fracture toughness were characterized as a function of temperature in various orientations relative to the grain and inclusion structures. This database along with extensive fractography suggests that brittleness is due to the presence of a large volume fraction of impurity alumina stringers. In orientations where the effects of the stringers are reduced, much higher toughness was observed. These results provide a path for alloy development approach to achieve high strength and toughness.

  15. "Ma vannun tema niuete kui paleuse nimel ..." : [luuletused] / tlk. Andres Ehin, tlk. Ly Seppel

    Index Scriptorium Estoniae

    2004-01-01

    Sisu: "Ma vannun tema niuete kui paleuse nimel ..." ; "Ta on nagu kuu, kelle kuma kõik kummuli kukutab ..." ; "Kuu südaöösel ennustab me jäävat lahkujääma ..." ; "Ei hinda naisterahvas kasinuse mulli ..." ; "Ta nõtket kaela kutsun ligemale ..." ; "Meid ühte heitma tõmbab armuköis ..." ; "Meil kahel pole mõtet lahku minna ..." ; "Ei kuuga saa võrrelda sind, sest et kuu läheb looja ..." ; "Allah ise su ilude hoob on ja kang ..." ; "Kui meesterahvale läeb korda meesterahvas ..." ; "Ja kuis ka kiremöll tal südames ei hulla ..." ; "Teie jaoks ei ole minu võlurohke kallike ..." ; "Oli see vast poisike, nägu ilu täis ..." ; "Aeg tagasi kalli las toob, et mind suisa salvata ...". Tundmatute autorite kirjutatud luuletused jutukogust "1001 ööd" (9. - 10. saj)

  16. Modélisation du vieillissement des anciens tunnels maçonnés

    OpenAIRE

    Idris, Jamal; Verdel, Thierry; AL HEIB, Marwan; Piguet, Jack-Pierre

    2006-01-01

    National audience; Les tunnels anciens sont généralement soutenus ou revêtus de structures en maçonnerie qui vieillissent avec le temps. Nous proposons ici une analyse du comportement de ces ouvrages par la technique des plans d'expérience appliquée à des expériences numériques, et en particulier à des modèles numériques avec la méthode des éléments distincts. Cette analyse vise la compréhension de l'évolution du comportement de la maçonnerie dans le temps et l'évaluation de l'influence des p...

  17. Exploring the Origin of Kinematically Irregular Galaxies with MaNGA

    Science.gov (United States)

    Stark, David Vincent; Bundy, Kevin; Westfall, Kyle; Bershady, Matthew; Cheung, Edmond; Soler, Juan; Brinchmann, Jarle; Abraham, Roberto; Bizyaev, Dmitry; Masters, Karen; Weijmans, Anne-Marie; Chen, Yanmei; Jin, Yifei; Drory, Niv; Lopes, Alexandre Roman; Law, David

    2018-01-01

    Deviations from normal rotation in galaxies may have a number of potential drivers, including tidal interactions, gas inflows/outflows, spiral structure, bar/oval distortions, or other internally generated instabilities. Thanks to new massive IFU surveys like MaNGA, we can now characterize the gas and stellar kinematics of thousands of galaxies in the local universe, enabling statistical analyses on the frequency of disturbed kinematics, their origin, and their impact on their host galaxies. We present a census of kinematics in MaNGA using a modified version of the Radon transform to map radial variations in kinematic position angles (PA). We discuss the frequency of kinematically irregular disks, and describe commonly observed patterns in radial PA profiles. In order to constrain the drivers of these kinematic signatures, we analyze how they correlate with galaxy mass, environment, star formation history, and gas-phase metallicity.

  18. Star formation history of the galaxy merger Mrk848 with SDSS-IV MaNGA

    Science.gov (United States)

    Yuan, Fang-Ting; Shen, Shiyin; Hao, Lei; Fernandez, Maria Argudo

    2017-03-01

    With the 3D data of SDSS-IV MaNGA (Bundy et al. 2015) spectra and multi-wavelength SED modeling, we expect to have a better understanding of the distribution of dust, gas and star formation of galaxy mergers. For a case study of the merging galaxy Mrk848, we use both UV-to-IR broadband SED and the MaNGA integral field spectroscopy to obtain its star formation histories at the tail and core regions. From the SED fitting and full spectral fitting, we find that the star formation in the tail regions are affected by the interaction earlier than the core regions. The core regions show apparently two times of star formation and a strong burst within 500Myr, indicating the recent star formation is triggered by the interaction. The star formation histories derived from these two methods are basically consistent.

  19. Structure of Oxide Nanoparticles in Fe-16Cr MA/ODS Ferritic Steel

    Energy Technology Data Exchange (ETDEWEB)

    Hsiung, L; Fluss, M; Kimura, A

    2010-04-06

    Oxide nanoparticles in Fe-16Cr ODS ferritic steel fabricated by mechanical alloying (MA) method have been examined using high-resolution transmission electron microscopy (HRTEM) techniques. A partial crystallization of oxide nanoparticles was frequently observed in as-fabricated ODS steel. The crystal structure of crystalline oxide particles is identified to be mainly Y{sub 4}Al{sub 2}O{sub 9} (YAM) with a monoclinic structure. Large nanoparticles with a diameter larger than 20 nm tend to be incoherent and have a nearly spherical shape, whereas small nanoparticles with a diameter smaller than 10 nm tend to be coherent or semi-coherent and have faceted boundaries. The oxide nanoparticles become fully crystallized after prolonged annealing at 900 C. These results lead us to propose a three-stage formation mechanism of oxide nanoparticles in MA/ODS steels.

  20. O Sentido da metamorfose: precariedade e permanência em Macunaíma

    Directory of Open Access Journals (Sweden)

    Ettore Finazzi

    1993-10-01

    Full Text Available The carnal attitude affected by Macunaíma, the "hero without any trah" of Mário de Andrade's novel (1928, allows us to reconsider this character as an emblem of body, cancelling (in accordance with Bakhtin's. opinion the barriers between "interior" and "exterior" -a body that passes across the "full places" of identity, combining manifold experiences into a substancial, ideological, uniformity. In this sense, the amorphous condition of Andrade's hero, in connection with his ability to "enter in another's body" (Starobinsky, with his metamorphosing faculty, becomes a paradigm of the Brazilian condition, which is also characterized by his tendency to identify itself in an absence, as a product of mediation between different cultural pattems. Macunaíma, as a text and as a character, is, after all, the novelization, the "metaphor" (Rella, of an identity that consists of a lack, that lasts into and across the transformation.