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Sample records for spotlight elena angulo1

  1. ELENA

    CERN Multimedia

    Caraban Gonzalez, Noemi

    2016-01-01

    ELENA is a compact ring for cooling and further deceleration of 5.3 MeV antiprotons delivered by the CERN Antiproton Decelerator. The AD physics program is focused on trapping antiprotons in Penning traps where antihydrogen is formed after recombination with positrons. The ultimate physics goal is to perform spectroscopy on antihydrogen atoms at rest and to investigate the effect of the gravitational force on matter and antimatter.

  2. Elena App for Android

    NARCIS (Netherlands)

    Ternier, Stefaan; Rusman, Ellen; Storm, Jeroen

    2014-01-01

    The ‘ELENA goes shopping' mobile game is developed within the ELENA-project. This European project develops materials to teach children between 4 and 8 years the basics of French, German and Dutch. The aim is to familiarize children from border regions with languages that are available in their

  3. The ELENA facility

    Science.gov (United States)

    Bartmann, Wolfgang; Belochitskii, Pavel; Breuker, Horst; Butin, Francois; Carli, Christian; Eriksson, Tommy; Oelert, Walter; Ostojic, Ranko; Pasinelli, Sergio; Tranquille, Gerard

    2018-03-01

    The CERN Antiproton Decelerator (AD) provides antiproton beams with a kinetic energy of 5.3 MeV to an active user community. The experiments would profit from a lower beam energy, but this extraction energy is the lowest one possible under good conditions with the given circumference of the AD. The Extra Low Energy Antiproton ring (ELENA) is a small synchrotron with a circumference a factor of 6 smaller than the AD to further decelerate antiprotons from the AD from 5.3 MeV to 100 keV. Controlled deceleration in a synchrotron equipped with an electron cooler to reduce emittances in all three planes will allow the existing AD experiments to increase substantially their antiproton capture efficiencies and render new experiments possible. ELENA ring commissioning is taking place at present and first beams to a new experiment installed in a new experimental area are foreseen in 2017. The transfer lines from ELENA to existing experiments in the old experimental area will be installed during CERN Long Shutdown 2 (LS2) in 2019 and 2020. The status of the project and ring commissioning will be reported. This article is part of the Theo Murphy meeting issue `Antiproton physics in the ELENA era'.

  4. ELENA Project - Experiment soon complete

    CERN Multimedia

    Brice, Maximilien

    2016-01-01

    ELENA is a compact ring for cooling and further deceleration of 5.3 MeV antiprotons delivered by the CERN Antiproton Decelerator. The AD physics program is focused on trapping antiprotons in Penning traps where antihydrogen is formed after recombination with positrons. The ultimate physics goal is to perform spectroscopy on antihydrogen atoms at rest and to investigate the effect of the gravitational force on matter and antimatter.

  5. The ELENA project at CERN

    CERN Document Server

    Oelert, W

    2015-01-01

    CERN has a longstanding tradition of pursuing fundamental physics on extreme low and high energy scales. The present physics knowledge is successfully described by the Standard Model and the General Relativity. In the anti-matter regime many predictions of this established theory still remain experimentally unverified and one of the most fundamental open problems in physics concerns the question of asymmetry between particles: why is the observable and visible universe apparently composed almost entirely of matter and not of anti-matter? There is a huge interest in the very compelling scientiic case for anti-hydrogen and low energy anti-proton physics, here to name especially the Workshop on New Opportunities in the Physics Landscape at CERN which was convened in May 2009 by the CERN Directorate and culminated in the decision for the final approval of the construction of the Extra Low ENergy Antiproton (ELENA) ring by the Research Board in June 2011. ELENA is a CERN project aiming to construct a small 30 m ci...

  6. Elena

    Directory of Open Access Journals (Sweden)

    Elena María Ospina Mejía

    1987-05-01

    Full Text Available Sus caricaturas y dibujos de humor gráfico tienen la formalidad y la limpieza que se utiliza en el diseño publicitario que le quitan la agresividad de sus temas. Su humor se convierte en amable y siempre es refrendado con la picardía ingenua de una sonrisa.

  7. Color homogeneity in LED spotlights

    NARCIS (Netherlands)

    Prins, C.R.; Tukker, T.W.; IJzerman, W.L.; Thije Boonkkamp, ten J.H.M.

    2014-01-01

    LED is a rising technology in the field of lighting. Halogen spotlights are nowadays replaced by LED spotlights because of their energy efficiency and long lifetime. However, color variation in the light output is a common problem. Poorly designed LED spotlights tend to have yellowish or bluish

  8. NEUTRINOS: Moriond spotlight

    Energy Technology Data Exchange (ETDEWEB)

    Petcov, S. T.

    1991-05-15

    The regular 'Rencontres de Moriond' meetings in the French Alps, which celebrate their 25th anniversary this year, have a strong tradition of reflecting new trends in physics thinking and January's session on 'Tests of Fundamental Laws in Physics' was no exception. The spotlight this time fell on the neutrino sector, a branch of physics frequently in evolution, if not controversial.

  9. Significant Silence in Elena Garro's "Los Perros"

    Science.gov (United States)

    Burke, Jessica

    2010-01-01

    Elena Garro's one-act play "Los perros" (1958) confronts the difficult issue of sexual violence in rural Mexico, a problem that persists today. The characters struggle with the social reality of rape, alluding to the threat of sexual violence while avoiding addressing it directly. While words are granted an almost magical power in…

  10. Ecotourism: The Santa Elena Rainforest Project.

    Science.gov (United States)

    Wearing, Stephen

    1993-01-01

    Describes an ecotourism project in which the community of Santa Elena, Costa Rica, are developing a rainforest reserve on government land leased permanently to the local high school. Discusses the impact of the project on the community's economy and environment. (Contains 30 references.) (MDH)

  11. NEUTRINOS: Moriond spotlight

    International Nuclear Information System (INIS)

    Petcov, S.T.

    1991-01-01

    The regular 'Rencontres de Moriond' meetings in the French Alps, which celebrate their 25th anniversary this year, have a strong tradition of reflecting new trends in physics thinking and January's session on 'Tests of Fundamental Laws in Physics' was no exception. The spotlight this time fell on the neutrino sector, a branch of physics frequently in evolution, if not controversial

  12. Design Study: ELENA Bending Magnet Prototype

    CERN Document Server

    Schoerling, D

    2013-01-01

    The ELENA bending magnet prototype shall prove that the proposed design meets the requirements set by the ELENA beam dynamics. The following points will be discussed in detail: (i) production process of a magnetic yoke diluted with stainless steel plates, (ii) the stability and repeatability of the field homogeneity of such a yoke over the full working range, (iii) choice of soft magnetic steel, (iv) hysteresis effects, (v) mechanical deformations, (vi) thermal insulation to intercept heat load from baking for activation of NEG coating in the vacuum chamber, (vii) end shim design. In order to verify these points the following measurements will be performed: (i) Hall probe scanning, (ii) integrated field homogeneity measurement (DC), (iii) integrated field homogeneity measurement (AC).

  13. ELENA gets a roof over its head

    CERN Document Server

    Anaïs Schaeffer

    2014-01-01

    Today, Friday 11 April, CERN inaugurated the ELENA building (393) after less than a year's construction work.   Tacked on to the side of the Antiproton Decelerator (AD), this building will soon house a cleaning room, workshops and generators for the kickers in order to free space in the AD hall, where the future Extra Low ENergy Antiproton ring, ELENA, will be installed. “Today we’re celebrating the completion of a project which, I’m happy to say, has gone very well,” exclaims François Butin, technical coordinator of the ELENA project (EN-MEF Group). “The deadlines and budgets have been perfectly respected and the building fully complies with our specifications. A great vote of thanks to GS-SE and the outside contractors who have enabled us to complete this project.” Some 10,000 tonnes of earth had to be moved by around 500 trucks. The presence of the TT2 transfer tunnel directly beneath the building posed a number...

  14. Helena Paz-Elena Garro: La Memoria Compartida Helena Paz-Elena Garro: La Memoria Compartida

    Directory of Open Access Journals (Sweden)

    Ana María Alba Villalobos

    2012-02-01

    Full Text Available En el texto se analizan las Memorias de Helena Paz, a la luz de los textos autobiográficos y biográficos acerca de la vida de Elena Garro. El planteamiento estriba en que hay muchos elementos que permiten afirmar que una parte sustancial de las memorias (inéditas de Elena Garro se encuentran insertas en las Memorias de su hija, Helena Paz. Se muestran aquí los argumentos para tal aseveración y los fragmentos que corresponderían a las vivencias de la madre, más que de la hija This text analyzes Helena Paz’s Memoirs, in the light of the autobiographical and biographical texts about Elena Garro’s life. The thesis of the text is that there are many elements supporting the statement that a substantial part of Elena Garro’s unedited memoirs are found inserted in her daughter’s (Helena Paz’s Memoirs. Arguments for such an assertion are presented, together with the excerpts which would correspond more to the experiences of the mother than to those of the daughter.

  15. AD performance and its extension towards ELENA

    Energy Technology Data Exchange (ETDEWEB)

    Oelert, Walter, E-mail: w.oelert@fz-juelich.de [Forschungszentrum Juelich (Germany); Eriksson, Tommy, E-mail: Tommy.Eriksson@cern.ch; Belochitskii, Pavel, E-mail: Pavel.Beloshitsky@cern.ch; Tranquille, Gerard, E-mail: Gerard.Tranquille@cern.ch [CERN (Switzerland)

    2012-12-15

    The CERN's Antiproton Decelerator (AD) is devoted to special experiments with low energy antiprotons. A main topic is the antihydrogen production with the present aim to produce these antimatter atoms with such low energy that they can be trapped in a magnetic gradient field. First very convincing results have been published recently by ALPHA. Still, it appears to be cumbersome, time consuming and ineffective when collecting the needed large numbers and high densities of antiproton clouds with the present AD. Both the effectiveness and the availability for additional experiments at this unique facility would drastically increase, if the antiproton beam of presently 5 MeV kinetic energy would be reduced by an additional decelerator to something like 100 keV. Such a facility 'ELENA', as an abbreviation for Extra Low ENergy Antiproton Ring and first discussed in 1982 for LEAR, was freshly proposed with a substantial new design and revised layout and is presently under consideration. ELENA will increase the number of useful antiprotons by up to two orders of magnitude and will allow to serve up to four experiments in parallel.

  16. Living in the spotlight

    CERN Multimedia

    2009-01-01

    Just a few weeks ago, we celebrated the 20th anniversary of the World Wide Web. It gave me my first opportunity since taking up my mandate to see first hand what CERN’s newfound public profile means in practice. There were over 60 media from around the world present at CERN for the event, and some 900 reports in the media over the following days. Some weeks before, Sony pictures held a press event for their upcoming movie, Angels and Demons, part of which takes place at CERN. That happened during the same week that we published the new LHC schedule, and it was the LHC that got the most media coverage. So what does this mean for how we carry out our daily work? Particle physics has always operated in a fully open and transparent way. It’s in our DNA to do so. Meetings are open to all comers, and it is important that we continue to foster such a culture of transparency. Nevertheless, we need to be aware that we are much more in the public spotlight than ever before....

  17. The AD and ELENA orbit, trajectory and intensity measurement systems

    Science.gov (United States)

    Marco-Hernández, R.; Alves, D.; Angoletta, M. E.; Marqversen, O.; Molendijk, J.; Oponowicz, E.; Ruffieux, R.; Sánchez-Quesada, J.; SØby, L.

    2017-07-01

    This paper describes the new Antiproton Decelerator (AD) orbit measurement system and the Extra Low ENergy Antiproton ring (ELENA) orbit, trajectory and intensity measurement system. The AD machine at European Organization for Nuclear Research (CERN) is presently being used to decelerate antiprotons from 3.57 GeV/c to 100 MeV/c for matter vs anti-matter comparative studies. The ELENA machine, presently under commissioning, has been designed to provide an extra deceleration stage down to 13.7 MeV/c. The AD orbit system is based on 32 horizontal and 27 vertical electrostatic Beam Position Monitor (BPM) fitted with existing low noise front-end amplifiers while the ELENA system consists of 24 \\gls{BPM}s equipped with new low-noise head amplifiers. In both systems the front-end amplifiers generate a difference (delta) and a sum (sigma) signal which are sent to the digital acquisition system, placed tens of meters away from the AD or ELENA rings, where they are digitized and further processed. The beam position is calculated by dividing the difference signal by the sum signal either using directly the raw digitized data for measuring the turn-by-turn trajectory in the ELENA system or after down-mixing the signals to baseband for the orbit measurement in both machines. The digitized sigma signal will be used in the ELENA system to calculate the bunched beam intensity and the Schottky parameters with coasting beam after passing through different signal processing chain. The digital acquisition arrangement for both systems is based on the same hardware, also used in the ELENA Low Level Radio Frequency (LLRF) system, which follows the VME Switched Serial (VXS) enhancement of the Versa Module Eurocard 64x extension (VME64x) standard and includes VITA 57 standard Field Programmable Gate Array Mezzanine Card (FMC). The digital acquisition Field Programmable Gate Array (FPGA) and Digital Signal Processor (DSP) firmware shares many common functionalities with the LLRF system but

  18. Color homogeneity in LED spotlights

    NARCIS (Netherlands)

    Prins, C.R.

    2013-01-01

    Color variation in the light output of white LEDs is a common problem in LED lighting. We aim to design LED spotlights with a uniform color output while keeping the cost of the system low and the energy efficiency high. Therefore we design a special optic to eliminate the color variation of the LED.

  19. AD performance and its extension towards ELENA

    International Nuclear Information System (INIS)

    Oelert, Walter; Eriksson, Tommy; Belochitskii, Pavel; Tranquille, Gerard

    2012-01-01

    The CERN’s Antiproton Decelerator (AD) is devoted to special experiments with low energy antiprotons. A main topic is the antihydrogen production with the present aim to produce these antimatter atoms with such low energy that they can be trapped in a magnetic gradient field. First very convincing results have been published recently by ALPHA. Still, it appears to be cumbersome, time consuming and ineffective when collecting the needed large numbers and high densities of antiproton clouds with the present AD. Both the effectiveness and the availability for additional experiments at this unique facility would drastically increase, if the antiproton beam of presently 5 MeV kinetic energy would be reduced by an additional decelerator to something like 100 keV. Such a facility ”ELENA”, as an abbreviation for Extra Low ENergy Antiproton Ring and first discussed in 1982 for LEAR, was freshly proposed with a substantial new design and revised layout and is presently under consideration. ELENA will increase the number of useful antiprotons by up to two orders of magnitude and will allow to serve up to four experiments in parallel.

  20. Santa Elena. Ready to reshape its transport energy matrix

    Energy Technology Data Exchange (ETDEWEB)

    Moreano, Hernan [Universidad Estatal Peninsula de Santa Elena (Ecuador). Inst. de Investigacion Cientifica y Desarrollo Tecnologico (INCYT)

    2012-07-01

    The renewable energy issue opens the door to an ambient of opportunities. Santa Elena, one of the coastal provinces of Ecuador has the chance to go from a fossil fuel energy culture to a new energy scheme based on the use of environmental friendly fuels like natural gas and other renewable energy carriers like hydrogen. The marginal production of oil and natural gas from the Gustavo Galindo Velasco field and the updated gas reserves from the Gulf of Guayaquil make it possible. Infrastructure for natural gas production and distribution for vehicles is almost ready and any of the three refineries can generate hydrogen from natural gas. This provides the opportunity to reshape the Santa Elena transport energy matrix, where vehicles can burn natural gas and inter country buses can work with hydrogen. Traditional Fishing boats can be fitted with hydrogen storage and fuel systems later on. Santa Elena should face this challenge through a joint effort of public and private parties. Santa Elena State University and its partners as a focus point to create: The Campus of Energy Knowledge, where research, science and technology will serve companies that work in the energy business with a strong synergy, which will create jobs for the Santa Elena people. (orig.)

  1. ELENA prepares a bright future for antimatter research

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    At its recent session in June, the CERN Council approved the construction of the Extra Low ENergy Antiproton ring (ELENA) – an upgrade of the existing Antiproton Decelerator. ELENA will allow the further deceleration of antiprotons, resulting in an increased number of particles trapped downstream in the experimental set-ups. This will give an important boost to antimatter research in the years to come.   Layout of the AD experimental hall: the Antiproton Decelerator ring (purple); the ALPHA, ASACUSA, and ATRAP experiments (green); the ACE experiment (not pictured); and the new ELENA ring (blue). The Antiproton Decelerator (AD) is CERN’s widely recognized facility for the study of antimatter properties. The recent successes of the AD experiments are just the latest in a long list of important scientific results that started with LEAR (Low Energy Antiproton Ring). The scientific demand for low-energy antiprotons at the AD continues to grow. There are now four experiments runnin...

  2. Concept for ELENA Extraction and Beam Transfer Elements

    CERN Document Server

    Borburgh, J; Balhan, B; Barna, D; Bartmann, W; Fowler, T; Pricop, V; Sermeus, L; Vanbavinckhove, G

    2013-01-01

    In 2011 the ELENA decelerator was approved as a CERN project. Initially one extraction was foreseen, which should use a kicker and a magnetic septum which can be recuperated from an earlier installation. Since then a second extraction has been approved and a new solution was studied using only electric fields to extract the beam. This will be achieved by fast pulsing a separator, allowing single-bunch but also a full single-turn extraction from ELENA towards the experiments. The extraction and transfer requirements of ELENA are described, followed by the principal differences between the magnetic and electric field concepts. The design of electrostatic focussing and bending devices for the transfer lines will be presented. Finally the field quality which can be achieved with the separator and the concept of its power supply will be discussed.

  3. Geometry and Optics of the Electrostatic ELENA Transfer Lines

    CERN Document Server

    Vanbavinckhove, G; Barna, D; Bartmann, W; Butin, F; Choisnet, O; Yamada, H

    2013-01-01

    The future ELENA ring at CERN will decelerate the AD anti-proton beam further from 5.3 MeV to 100 keV kinetic energy, to increase the efficiency of anti-proton trapping. At present there are four experiments in the AD hall which will be complemented with the installation of ELENA by additional three experiments and an additional source for commissioning. This paper describes the optimization of the transfer line geometry, ring rotation and source position. The optics of the transfer lines and error studies to define field and alignment tolerances are shown, and the optics particularities of electrostatic elements and their optimization highlighted.

  4. Personajes y escenarios en las performances de Elena Tejada

    OpenAIRE

    Mendoza, Mihaela Radulescu de Barrio de

    2017-01-01

    The paper focuses on the enunciative aspects of the art performances of the Peruvian artist Elena Tejada to deepen the effects of meaning generated by the theatrical performance. The construction of characters and scenarios provides the necessary contents for the rituals of integration of the public in the symbolic experience that the performances generate info:eu-repo/semantics/publishedVersion

  5. Sfera Politicii's Archive - Elena Ceausescu in the records

    Directory of Open Access Journals (Sweden)

    Stelian Tănase

    2011-10-01

    Full Text Available I don’t know why the idea that Elena Ceauşescu was the key element of her husband’s regime slowly stared to take shape. It is said that by growing older he started to lose his capacity of taking decisions, so he was more and more dependent on her. The idea is credited by a serious number of historians. However, this is a false perspective.

  6. Unlocking investment in cities: ELENA-EIB technical assistance facility

    International Nuclear Information System (INIS)

    Cicmanova, Jana; Garabetian, Thomas

    2015-06-01

    Energy Cities prepared a review of projects undertaken in the cities of Paris, Malmoe (in association with Lund and Helsingborg), Barcelona, Bristol and Brussels-Capital that received support from the ELENA-EIB facility. The aim of this study is to identify the ways in which technical assistance programs such as ELENA-EIB can help unlock investment in cities. The projects we reviewed (developed by Energy Cities' members) cover a wide array of sectors, from public building refurbishment to public transport or renewable energy production. These five projects illustrate how cities can focus on developing capacity in a long-term perspective, looking at the expected benefits of an investment or a support mechanism beyond that of the project itself. Overall, we found that project development assistance mechanisms such as ELENA can be beneficial to trigger investment for climate action in cities. Cities maximise the benefits of such a program by looking at how their climate-protection actions can generate benefits for the citizens, or how to systematically integrate climate action in other investment projects. Project development assistance (PDA) affects cities by allowing them to develop a new vision of the way they prepare an investment program. The search of synergies and the override of silo mentalities were a core element in the projects we reviewed. Indeed, the support provided by the European Union through ELENA-EIB is used by the local authorities to develop a transversal approach to climate action. The grant provided for PDA and the requirements of the ELENA-EIB facility represent an opportunity for local authorities to set up a new strategy regarding energy efficiency and renewable energy actions. It can be the necessary push for cities and local authorities to change the way they plan their investments, and develop projects to achieve their climate objectives. Besides, the grant is used for building long-term capacity in the development of investment programs

  7. Elena: A case of dissociative identity disorder from the 1920s.

    Science.gov (United States)

    Schimmenti, Adriano

    2017-01-01

    In 1930, Italian psychiatrist Giovanni Enrico Morselli described the history, diagnosis, and treatment of his patient Elena. The case of Elena has been considered in literature as one of the most remarkable cases of multiple personality ever published. In fact, before treatment, Elena showed alternating French- and Italian-speaking personalities, with the Italian personality knowing nothing of her French counterparts. After a difficult treatment involving recovered memories of incestuous attacks by her father, which were proven to be true, Elena fully recovered from her symptoms. In this article, the author presents details of the case that were not available in the international literature before. He also discusses Elena's psychological and somatoform symptoms according to a contemporary perspective on the relationally traumatic origins of dissociation and dissociative identity disorder.

  8. Holding a spotlight to an ageing society.

    Science.gov (United States)

    Cann, Paul

    2008-07-01

    In May 2008 Help the Aged published its 3rd annual Spotlight Report. The report highlights the stark realities facing older people in the UK today and gives detailed statistical data on how the lives of some have improved but many are still being left behind.

  9. Elena Guardincerri: Tracking muons to reduce nuclear threats and help preserve architectural treasures

    Energy Technology Data Exchange (ETDEWEB)

    Del Mauro, Diana [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Guardincerri, Elena [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-29

    When Elena Guardincerri was a physics PhD student at the University of Genova, she considered muons a nuisance. She built muon detectors to snare these secondary cosmic rays, which were interfering with her experiments to study elusive neutrinos.

  10. Elena Natale ja Mikko Fritze: kultuuripealinna tiimi motivatsioon on töö ise / Elena Natale, Mikko Fritze ; intervjueerinud Tiina Saar

    Index Scriptorium Estoniae

    Natale, Elena

    2009-01-01

    SA Tallinn 2011 tegevjuht Mikko Fritze ja administratiivjuht Elena Natale vastavad küsimustele, mis puudutavad Eesti töökultuuri, , toimiva koostöö saavutamist meeskonnas, kasutatavaid motivatsiooni- ja juhtimissüsteeme, personalivalikut, majanduskriisi mõju SA Tallinn 2011 tegevusele

  11. Detecting swift fox: Smoked-plate scent stations versus spotlighting

    Science.gov (United States)

    Daniel W. Uresk; Kieth E. Severson; Jody Javersak

    2003-01-01

    We compared two methods of detecting presence of swift fox: smoked-plate scent stations and spotlight counts. Tracks were counted on ten 1-mile (1.6-km) transects with bait/tracking plate stations every 0.1 mile (0.16 km). Vehicle spotlight counts were conducted on the same transects. Methods were compared with Spearman's rank order correlation. Repeated measures...

  12. The Learning Management System Evolution. CDS Spotlight Report. Research Bulletin

    Science.gov (United States)

    Lang, Leah; Pirani, Judith A.

    2014-01-01

    This Spotlight focuses on data from the 2013 Core Data Service (CDS) to better understand how higher education institutions approach learning management systems (LMSs). Information provided for this Spotlight was derived from Module 8 of the Core Data Service, which contains several questions regarding information systems and applications.…

  13. Extra Low Energy Antiproton ring ELENA : from the conception to the implementation phase

    CERN Document Server

    Bartmann, W; Breuker, H; Butin, F; Carli, C; Eriksson, T; Maury, S; Pasinelli, S; Tranquille, G; Oelert, W

    2014-01-01

    The Extra Low Energy Antiproton ring (ELENA) is a CERN project aiming at constructing a small 30 m circumference synchrotron to further decelerate antiprotons from the Antiproton Decelerator AD from 5.3 MeV to 100 keV. Controlled deceleration in a synchrotron equipped with an electron cooler to reduce emittances in all three planes will allow the existing AD experiments to increase substantially their antiproton capture efficiencies and render new experiments possible. The ELENA design is now well advanced and the project is moving to the implementation phase. Component design and construction are taking place at present for installation foreseen during the second half of 2015 and beginning of 2016 followed by ring commissioning until the end of 2016. New electrostatic transfer lines to the experiments will be installed and commissioned during the first half of 2017 followed by the first physics operation with ELENA. Basic limitations like Intra Beam Scattering limiting the emittances obtained under electron ...

  14. Nuclear Fuels & Materials Spotlight Volume 4

    Energy Technology Data Exchange (ETDEWEB)

    I. J. van Rooyen,; T. M. Lillo; Y. Q. WU; P.A. Demkowicz; L. Scott; D.M. Scates; E. L. Reber; J. H. Jackson; J. A. Smith; D.L. Cottle; B.H. Rabin; M.R. Tonks; S.B. Biner; Y. Zhang; R.L. Williamson; S.R. Novascone; B.W. Spencer; J.D. Hales; D.R. Gaston; C.J. Permann; D. Anders; S.L. Hayes; P.C. Millett; D. Andersson; C. Stanek; R. Ali; S.L. Garrett; J.E. Daw; J.L. Rempe; J. Palmer; B. Tittmann; B. Reinhardt; G. Kohse; P. Ramuhali; H.T. Chien; T. Unruh; B.M. Chase; D.W. Nigg; G. Imel; J. T. Harris

    2014-04-01

    As the nation's nuclear energy laboratory, Idaho National Laboratory brings together talented people and specialized nuclear research capability to accomplish our mission. This edition of the Nuclear Fuels and Materials Division Spotlight provides an overview of some of our recent accomplishments in research and capability development. These accomplishments include: • The first identification of silver and palladium migrating through the SiC layer in TRISO fuel • A description of irradiation assisted stress corrosion testing capabilities that support commercial light water reactor life extension • Results of high-temperature safety testing on coated particle fuels irradiated in the ATR • New methods for testing the integrity of irradiated plate-type reactor fuel • Description of a 'Smart Fuel' concept that wirelessly provides real time information about changes in nuclear fuel properties and operating conditions • Development and testing of ultrasonic transducers and real-time flux sensors for use inside reactor cores, and • An example of a capsule irradiation test. Throughout Spotlight, you'll find examples of productive partnerships with academia, industry, and government agencies that deliver high-impact outcomes. The work conducted at Idaho National Laboratory helps to spur innovation in nuclear energy applications that drive economic growth and energy security. We appreciate your interest in our work here at INL, and hope that you find this issue informative.

  15. Vulnerabilidades frente amenazas naturales en establecimientos de salud de la Provincia de Santa Elena

    OpenAIRE

    Bertha De Monserrate

    2015-01-01

    Un equipo de análisis de riesgos de la Universidad Estatal Península de Santa Elena y Cooperazione Internationale durante el año 2010, llevó a cabo un estudio de vulnerabilidad de los establecimientos de salud de la provincia de Santa Elena frente a amenazas naturales de tsunami, inundación, erosión y movimiento en masa. El objetivo: evaluar los establecimientos de salud por tipos y nivel de atención, mediante la aplicación de los estándares establecidos en el Manual de Licenciamiento de Mini...

  16. Field Simulations and Mechanical Implementation of Electrostatic Elements for the ELENA Transfer Lines

    CERN Document Server

    Barna, D; Borburgh, J; Carli, C; Vanbavinckhove, G

    2014-01-01

    The Antiproton Decelerator (AD) complex at CERN will be extended by an extra low energy anti-proton ring (ELENA) [1] further decelerating the anti-protons thus improving their trapping. The kinetic energy of 100 keV at ELENA extraction facilitates the use of electrostatic transfer lines to the experiments. The mechanical implementation of the electrostatic devices are presented with focus on their alignment, bakeout compatibility, ultra-high vacuum compatibility and polarity switching. Field optimisations for an electrostatic crossing device of three beam lines are shown.

  17. Spotlight on Psoriasis: Preventing Patches of Itchy, Sore Skin

    Science.gov (United States)

    ... Subscribe August 2016 Print this issue Spotlight on Psoriasis Preventing Patches of Itchy, Sore Skin En español ... Sun Damage Sun and Skin Wise Choices Avoid Psoriasis Triggers Factors that may trigger psoriasis or make ...

  18. Nuclear Fuels & Materials Spotlight Volume 5

    International Nuclear Information System (INIS)

    Petti, David Andrew

    2016-01-01

    As the nation's nuclear energy laboratory, Idaho National Laboratory brings together talented people and specialized nuclear research capability to accomplish our mission. This edition of the Nuclear Fuels and Materials Division Spotlight provides an overview of some of our recent accomplishments in research and capability development. These accomplishments include: • Evaluation and modeling of light water reactor accident tolerant fuel concepts • Status and results of recent TRISO-coated particle fuel irradiations, post-irradiation examinations, high-temperature safety testing to demonstrate the accident performance of this fuel system, and advanced microscopy to improve the understanding of fission product transport in this fuel system. • Improvements in and applications of meso and engineering scale modeling of light water reactor fuel behavior under a range of operating conditions and postulated accidents (e.g., power ramping, loss of coolant accident, and reactivity initiated accidents) using the MARMOT and BISON codes. • Novel measurements of the properties of nuclear (actinide) materials under extreme conditions, (e.g. high pressure, low/high temperatures, high magnetic field) to improve the scientific understanding of these materials. • Modeling reactor pressure vessel behavior using the GRIZZLY code. • New methods using sound to sense temperature inside a reactor core. • Improved experimental capabilities to study the response of fusion reactor materials to a tritium plasma. Throughout Spotlight, you'll find examples of productive partnerships with academia, industry, and government agencies that deliver high-impact outcomes. The work conducted at Idaho National Laboratory helps spur innovation in nuclear energy applications that drive economic growth and energy security. We appreciate your interest in our work here at Idaho National Laboratory, and hope that you find this issue informative.

  19. Nuclear Fuels & Materials Spotlight Volume 5

    Energy Technology Data Exchange (ETDEWEB)

    Petti, David Andrew [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-10-01

    As the nation's nuclear energy laboratory, Idaho National Laboratory brings together talented people and specialized nuclear research capability to accomplish our mission. This edition of the Nuclear Fuels and Materials Division Spotlight provides an overview of some of our recent accomplishments in research and capability development. These accomplishments include: • Evaluation and modeling of light water reactor accident tolerant fuel concepts • Status and results of recent TRISO-coated particle fuel irradiations, post-irradiation examinations, high-temperature safety testing to demonstrate the accident performance of this fuel system, and advanced microscopy to improve the understanding of fission product transport in this fuel system. • Improvements in and applications of meso and engineering scale modeling of light water reactor fuel behavior under a range of operating conditions and postulated accidents (e.g., power ramping, loss of coolant accident, and reactivity initiated accidents) using the MARMOT and BISON codes. • Novel measurements of the properties of nuclear (actinide) materials under extreme conditions, (e.g. high pressure, low/high temperatures, high magnetic field) to improve the scientific understanding of these materials. • Modeling reactor pressure vessel behavior using the GRIZZLY code. • New methods using sound to sense temperature inside a reactor core. • Improved experimental capabilities to study the response of fusion reactor materials to a tritium plasma. Throughout Spotlight, you'll find examples of productive partnerships with academia, industry, and government agencies that deliver high-impact outcomes. The work conducted at Idaho National Laboratory helps spur innovation in nuclear energy applications that drive economic growth and energy security. We appreciate your interest in our work here at Idaho National Laboratory, and hope that you find this issue informative.

  20. Sotsiaalne kunst kui kodanikuõigus ja -kohustus / Rael Artel, Elena Šmakova

    Index Scriptorium Estoniae

    Artel, Rael, 1980-

    2010-01-01

    Vastukaja: Siram. Kunst, mis ei räägi inimestega (Eesti Ekspress, 2010, 8. apr., lk. 32). Kuraator Rael Artel Kumu Kunstimuuseumis eksponeeritud näitusest "Räägime rahvuslusest! Ideoloogia ja identiteedi vahel", kaasaegse kunsti mõistmisest. Elena Šmakova Rael Arteli kureeritud näitusest ja Tallinna Kunstihoones avatud Kristina Normani isikunäitusest "Me ei ole universumis üksi", kaasaegse kunsti kohta ilmunud kriitilistest artiklitest

  1. Longitudinal beam diagnostic from a distributed electrostatic pick-up in CERN's ELENA ring

    CERN Document Server

    Angoletta, M E; Federmann, S; Molendijk, J; Sanchez-Quesada, J; Secouet, P J; Søby, L; Pedersen, F; Timmins, M

    2013-01-01

    The CERN Extra Low ENergy Antiproton (ELENA) Ring is a new synchrotron that will be commissioned in 2016 to further decelerate the antiprotons coming from CERN’s Antiproton Decelerator (AD). Required longitudinal diagnostics include the intensity measurement for bunched and debunched beam and the measurement of Dp/p to assess the electron cooling performance. A novel method for the calculation of these parameters is proposed for ELENA, where signals from the twenty electrostatic Pick-Ups (PU) used for orbit measurements will be combined to improve the signal-to-noise ratio. This requires that the signals be digitally down-converted, rotated and summed so that the many electrostatic PUs will function as a single, distributed PU from the processing system viewpoint. This method includes some challenges and will not be used as the baseline longitudinal diagnostics for the initial ELENA operation. This paper gives an overview of the hardware and digital signal processing involved, as well as of the challenges t...

  2. Vulnerabilidades frente amenazas naturales en establecimientos de salud de la Provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Bertha De Monserrate

    2015-10-01

    Full Text Available Un equipo de análisis de riesgos de la Universidad Estatal Península de Santa Elena y Cooperazione Internationale durante el año 2010, llevó a cabo un estudio de vulnerabilidad de los establecimientos de salud de la provincia de Santa Elena frente a amenazas naturales de tsunami, inundación, erosión y movimiento en masa. El objetivo: evaluar los establecimientos de salud por tipos y nivel de atención, mediante la aplicación de los estándares establecidos en el Manual de Licenciamiento de Ministerio de Salud Pública y diagnosticar el grado de vulnerabilidad de la ubicación geográfica de los establecimientos de salud frente a las amenazas naturales, mediante la superposición de mapas de distribución geográfica y los mapas preliminares de amenazas a desastres naturales de la Secretaria General de Riesgos definida desde las amenazas en base a la guía para implementar el análisis de vulnerabilidades a nivel cantonal de esta secretaría. Resultados: la provincia de Santa Elena cuenta con 75 unidades de salud, 29 pertenecen al Ministerio de Salud Pública y 46 a Organizaciones no gubernamentales, el 75% brindan atención de primer nivel y el 25% segundo nivel básico. El estudio de vulnerabilidad mostró que el hospital de Manglaralto, los subcentros de San Francisco de las Núñez, San Pablo, Monteverde y el dispensario de la Superintendencia de la Libertad califican muy alto, mientras que el resto se considera de alto a medio. El Ministerio de Salud Pública debe reubicar aquellos establecimientos calificados como muy alto y alto.

  3. Composición del plancton en la Puntilla Santa Elena durante agosto 2002 (Ecuador)

    OpenAIRE

    Torres, G.; Calderón, G.; Franco, V.; Cedeño, E.; Calderón, T.; Salazar, E.

    2004-01-01

    Esta investigación comprende los estudios del fitoplancton-zooplancton-ictioplancton, realizados en tres sitios de la Península Santa Elena durante agosto 2002, área designada para la proyección de "Arrecife Artificial de las Fuerzas Militares del Ecuador": un avión, barco y tanque de guerra, estructuras artificiales consideradas como basura chatarra (de gran tamaño), que serían recicladas para la bio-exploración artificiales hacia la seguridad de los recursos marinos del Ecuador. En el Estud...

  4. Elena Poniatowska y la polifonía nocturna de Tlatelolco

    OpenAIRE

    Cervera Salinas, Vicente

    2008-01-01

    La crónica de Elena Poniatowska ha sido el inicio de su escritura testimonial. El análisis de La Noche de Tlatelolco implica coincidencias singulares con la política activa llevada a cabo por la escritora y resume la situación mexicana en un momento de represión estatal. El simbolismo de la plaza de Tlatelolco se remonta a los tiempos del virreinato, otorgándole un valor añadido. El diálogo entre los distintos tiempos y los textos que surgen de los acontecimientos como los de Octavio Paz y...

  5. New findings of Pleistocene fossil turtles (Geoemydidae, Kinosternidae and Chelydridae from Santa Elena Province, Ecuador

    Directory of Open Access Journals (Sweden)

    Edwin A. Cadena

    2017-04-01

    Full Text Available New Pleistocene fossilized turtle remains from five localities of western Ecuador (Santa Elena Province are described here. All these shell (carapace and plastron fossil remains come from the Tablazo Formation and belong to three different lineages of cryptodires (“hidden-necked” turtles. The most abundant remains belong to geoemydids, attributed here to the genus Rhinoclemmys (indeterminate species. Less abundant in occurrence are the kinosternidids, attributed to Kinosternon (indeterminate species, and the first fossil record of chelydrids, Chelydra(indeterminate species, in the entirety of Central and South America.

  6. Las otras primeras damas en la Argentina peronista: Elena Caporale de Mercante

    Directory of Open Access Journals (Sweden)

    Carolina Barry

    2016-07-01

    Full Text Available One of the most singular characteristics of peronism is the originality of holding within it a double charismatic leadership complementary to each other. The quintessential paradigm corresponds to Perón and Eva Perón, but there were other cases, more modest, that have served to cement the argentine political culture: the marriage at power. Those first ladies redefined its role, and built spaces of power and influence in government. In this paper I analyze the role of Elena Caporale de Mercante and her new political role as wife of the most important governor who had the first Peronist government.

  7. Hurricane Elena and Pinellas County, Florida: Some Lessons Learned from the Largest Evacuation of Nursing Home Patients in History.

    Science.gov (United States)

    Mangum, Wiley P.; And Others

    1989-01-01

    Studied prior planning for and problems associated with evacuation of 1,860 nursing home patients in Pinellas County, Florida, due to Hurricane Elena in 1985 through questionnaires administered to nursing home administrators and public documents. Found most serious problems to be transporting patients to shelters in timely fashion, delayed passage…

  8. The hELENa project - I. Stellar populations of early-type galaxies linked with local environment and galaxy mass

    NARCIS (Netherlands)

    Sybilska, A.; Lisker, T.; Kuntschner, H.; Vazdekis, A.; van de Ven, G.; Peletier, R.; Falcón-Barroso, J.; Vijayaraghavan, R.; Janz, J.

    2017-01-01

    We present the first in a series of papers in The role of Environment in shaping Low-mass Early-type Nearby galaxies (hELENa) project. In this paper, we combine our sample of 20 low-mass early types (dEs) with 258 massive early types (ETGs) from the ATLAS3D survey - all observed with the SAURON

  9. ELENA goes mobile’: a mobile assisted early language learning pilot for familiarizing children with neighbouring languages

    NARCIS (Netherlands)

    Rusman, Ellen; Ternier, Stefaan; Sassen, Derk

    2013-01-01

    Rusman, E., Ternier, S., & Sassen, D. (2013). ‘ELENA goes mobile’: a mobile assisted early language learning pilot for familiarizing children with neighbouring languages. In Pixel (Ed.), Proceedings of ICT for Language Learning, Conference Proceedings 2013, 6th Conference edition (pp. xx-xx).

  10. 'ELENA goes mobile': a mobile assisted early foreign language learning pilot for familiarizing children with neighbouring languages

    OpenAIRE

    Rusman, Ellen; Ternier, Stefaan; Sassen, Derk

    2013-01-01

    Rusman, E., Ternier, S., & Sassen, D. (2013, 14-15 November). 'ELENA goes mobile': a mobile assisted early foreign language learning pilot for familiarizing children with neighbouring languages. Presentation (virtual) at the 6th ICT for Language learning Conference, Florence, Italy. (URL of virtual presentation, including audio, will follow).

  11. ELENA goes mobile’: a mobile assisted early language learning pilot for familiarizing children with neighbouring languages

    OpenAIRE

    Rusman, Ellen; Ternier, Stefaan; Sassen, Derk

    2013-01-01

    Rusman, E., Ternier, S., & Sassen, D. (2013). ‘ELENA goes mobile’: a mobile assisted early language learning pilot for familiarizing children with neighbouring languages. In Pixel (Ed.), Proceedings of ICT for Language Learning, Conference Proceedings 2013, 6th Conference edition (pp. xx-xx). November, 14-15, 2013, Florence, Italy: Libreriauniversitaria.it Edizioni.

  12. 'ELENA goes mobile': a mobile assisted early foreign language learning pilot for familiarizing children with neighbouring languages

    NARCIS (Netherlands)

    Rusman, Ellen; Ternier, Stefaan; Sassen, Derk

    2013-01-01

    Rusman, E., Ternier, S., & Sassen, D. (2013, 14-15 November). 'ELENA goes mobile': a mobile assisted early foreign language learning pilot for familiarizing children with neighbouring languages. Presentation (virtual) at the 6th ICT for Language learning Conference, Florence, Italy. (URL of virtual

  13. ELENA MODENA, L'altrOrfeo. Considerazioni analitiche sulla vocalità, Roma, Aracne, 2009

    Directory of Open Access Journals (Sweden)

    Adriana Guarnieri

    2012-11-01

    Full Text Available Il volume propone un’indagine sulla vocalità ispirata al «metodo funzionale della voce» di Gisela Rohmert, didatta e fondatrice del Lichtenberger Institut für angewandte Stimmphysiologie, attivo in Germania dal 1982 . Da quell'esperienza – un metodo di pedagogia della voce fondato sullo studio della fisiologia vocale e del «fatto vocale» in quanto evento acustico e stimolo percettivo – Elena Modena ha derivato e illustra in questo libro una sua proposta di «analisi funzionale» della vocalità, storicamente considerata e rivolta, insieme, all’àmbito dell’emissione e a quello dell’ascolto.

  14. La "etnicidad marginal" de las comunas de la península de Santa Elena, Ecuador

    Directory of Open Access Journals (Sweden)

    Martín Bazurco

    2005-06-01

    Full Text Available Las comunas de la Península de Santa Elena representan la continuidad histórica de las antiguas jefaturas Manteño - Huancavilcas. Estas comunas han logrado mantener el control de su territorio y una relativa autonomía socio-económica a lo largo de todo el período colonial y republicano, poniendo en práctica diversas estrategias de articulación con la sociedad dominante. Sin embargo, la supervivencia de estas comunidades se debate, hoy en día, entre las agresiones extemas a su temitodo, y su "etnicidad marginal" que las excluye del marco constitucional ecuatoriano destinado a la protección de los tenitorios étnicos. A continuación se analiza el proceso de resignificación de la diversidad al que están abocadas las comunas de la PSE.

  15. Maximize Institutional Relationships with CRMs. CDS Spotlight Report. ECAR Research Bulletin

    Science.gov (United States)

    Lang, Leah; Pirani, Judith A.

    2014-01-01

    This Spotlight focuses on data from the 2013 Core Data Service (CDS) to better understand how higher education institutions approach customer relationship management (CRM) systems. Information provided for this Spotlight was derived from Module 8 of the Core Data survey, which asked several questions regarding information systems and applications.…

  16. BI Reporting, Data Warehouse Systems, and Beyond. CDS Spotlight Report. Research Bulletin

    Science.gov (United States)

    Lang, Leah; Pirani, Judith A.

    2014-01-01

    This Spotlight focuses on data from the 2013 Core Data Service [CDS] to better understand how higher education institutions approach business intelligence (BI) reporting and data warehouse systems (see the Sidebar for definitions). Information provided for this Spotlight was derived from Module 8 of CDS, which contains several questions regarding…

  17. The Financial Management System: A Pivotal Tool for Fiscal Viability. CDS Spotlight. ECAR Research Bulletin

    Science.gov (United States)

    Lang, Leah; Pirani, Judith A.

    2014-01-01

    This spotlight focuses on data from the 2013 CDS to better understand how higher education institutions approach financial management systems. Information provided for this spotlight was derived from Module 8 of Core Data Service (CDS), which asked several questions regarding information systems and applications. Responses from 525 institutions…

  18. Selective spatial enhancement: Attentional spotlight size impacts spatial but not temporal perception.

    Science.gov (United States)

    Goodhew, Stephanie C; Shen, Elizabeth; Edwards, Mark

    2016-08-01

    An important but often neglected aspect of attention is how changes in the attentional spotlight size impact perception. The zoom-lens model predicts that a small ("focal") attentional spotlight enhances all aspects of perception relative to a larger ("diffuse" spotlight). However, based on the physiological properties of the two major classes of visual cells (magnocellular and parvocellular neurons) we predicted trade-offs in spatial and temporal acuity as a function of spotlight size. Contrary to both of these accounts, however, across two experiments we found that attentional spotlight size affected spatial acuity, such that spatial acuity was enhanced for a focal relative to a diffuse spotlight, whereas the same modulations in spotlight size had no impact on temporal acuity. This likely reflects the function of attention: to induce the high spatial resolution of the fovea in periphery, where spatial resolution is poor but temporal resolution is good. It is adaptive, therefore, for the attentional spotlight to enhance spatial acuity, whereas enhancing temporal acuity does not confer the same benefit.

  19. AEgIS at ELENA: outlook for physics with a pulsed cold antihydrogen beam

    Science.gov (United States)

    Doser, M.; Aghion, S.; Amsler, C.; Bonomi, G.; Brusa, R. S.; Caccia, M.; Caravita, R.; Castelli, F.; Cerchiari, G.; Comparat, D.; Consolati, G.; Demetrio, A.; Di Noto, L.; Evans, C.; Fanì, M.; Ferragut, R.; Fesel, J.; Fontana, A.; Gerber, S.; Giammarchi, M.; Gligorova, A.; Guatieri, F.; Haider, S.; Hinterberger, A.; Holmestad, H.; Kellerbauer, A.; Khalidova, O.; Krasnický, D.; Lagomarsino, V.; Lansonneur, P.; Lebrun, P.; Malbrunot, C.; Mariazzi, S.; Marton, J.; Matveev, V.; Mazzotta, Z.; Müller, S. R.; Nebbia, G.; Nedelec, P.; Oberthaler, M.; Pacifico, N.; Pagano, D.; Penasa, L.; Petracek, V.; Prelz, F.; Prevedelli, M.; Rienaecker, B.; Robert, J.; Røhne, O. M.; Rotondi, A.; Sandaker, H.; Santoro, R.; Smestad, L.; Sorrentino, F.; Testera, G.; Tietje, I. C.; Widmann, E.; Yzombard, P.; Zimmer, C.; Zmeskal, J.; Zurlo, N.

    2018-03-01

    The efficient production of cold antihydrogen atoms in particle traps at CERN's Antiproton Decelerator has opened up the possibility of performing direct measurements of the Earth's gravitational acceleration on purely antimatter bodies. The goal of the AEgIS collaboration is to measure the value of g for antimatter using a pulsed source of cold antihydrogen and a Moiré deflectometer/Talbot-Lau interferometer. The same antihydrogen beam is also very well suited to measuring precisely the ground-state hyperfine splitting of the anti-atom. The antihydrogen formation mechanism chosen by AEgIS is resonant charge exchange between cold antiprotons and Rydberg positronium. A series of technical developments regarding positrons and positronium (Ps formation in a dedicated room-temperature target, spectroscopy of the n=1-3 and n=3-15 transitions in Ps, Ps formation in a target at 10 K inside the 1 T magnetic field of the experiment) as well as antiprotons (high-efficiency trapping of ?, radial compression to sub-millimetre radii of mixed ? plasmas in 1 T field, high-efficiency transfer of ? to the antihydrogen production trap using an in-flight launch and recapture procedure) were successfully implemented. Two further critical steps that are germane mainly to charge exchange formation of antihydrogen-cooling of antiprotons and formation of a beam of antihydrogen-are being addressed in parallel. The coming of ELENA will allow, in the very near future, the number of trappable antiprotons to be increased by more than a factor of 50. For the antihydrogen production scheme chosen by AEgIS, this will be reflected in a corresponding increase of produced antihydrogen atoms, leading to a significant reduction of measurement times and providing a path towards high-precision measurements. This article is part of the Theo Murphy meeting issue `Antiproton physics in the ELENA era'.

  20. Kogesime suurepärast meeskonnatööd / Liisi Lembinen, Elena Sipria-Mironov ; intervjueerinud Õnne Mets, Ene Riet

    Index Scriptorium Estoniae

    Lembinen, Liisi

    2014-01-01

    Tartu Ülikooli Raamatukogu osales EOD-projektis 2009. aasta maist kuni 2014. aasta aprillini. Kuidas projekt toimis ja mida saavutati, vastavad direktori kt Liisi Lembinen ja projektijuht Elena Sipria-Mironov

  1. Research Skills for the Future: Research Workforce Under the Spotlight

    Directory of Open Access Journals (Sweden)

    Eva Dobozy

    2013-01-01

    Full Text Available The value and training needs of the future research workforce is under the spotlight. In this article, I take up Ulrich and Dash's (2013 somewhat provocative invitation to engage in discussion and debate about current and future research. In my three-tiered response, I first discuss Ulrich and Dash's article, followed by my own observations about the APEC/Deloitte (2010 research report: "Skills and Competencies Needed in the Research Field: Objectives 2020," and finally, I explore, in some detail, challenges of building a twentyfirst-century research workforce.

  2. Manual de control interno para el área contable de la empresa industrial Santa Elena S.A. Empindecu, del cantón La Libertad, provincia de Santa Elena, año 2015.

    OpenAIRE

    Carrera Rivera, Stefanía Vanessa

    2015-01-01

    El presente trabajo de investigación previa la obtención del título de Licenciada en Contabilidad y Auditoría, tiene como objetivo primordial evaluar la incidencia de la gestión contable en las políticas y procedimientos, mediante un análisis situacional y la aplicación de técnicas de investigación, direccionados a la elaboración de un manual de control interno para el área contable de la Empresa Industrial Santa Elena S.A. EMPINDECU del cantón La Libertad provincia de Santa Elena. La empresa...

  3. Voicing Others’ Voices: Spotlighting the Researcher as Narrator

    Directory of Open Access Journals (Sweden)

    Dan O’SULLIVAN

    2015-12-01

    Full Text Available As qualitative research undertakings are not independent of the researcher, the “indissoluble interrelationship between interpreter and interpretation” (Thomas & James, 2006, p. 782 renders it necessary for researchers to understand that their text is a representation, a version of the truth that is the product of writerly choices, and that it is discursive. Endlessly creative, artistic and political, as there is no single interpretative truth, the interpretative process facilitates the refashioning of representations, the remaking of choices and the probing of discourses. As a consequence of the particularity of any researcher’s account, issues pertaining to researcher identity and authorial stance always remain central to research endeavours (Kamler & Thomson, 2006, p. 68; Denzin & Lincoln 2011, pp. 14-15. Therefore, researchers are encouraged to be reflexive about their analyses and research accounts (Elliott, 2005, p. 152, as reflexivity helps spotlight the role of the researcher as narrator. In turn, spotlighting the researcher as narrator foregrounds a range of complex issues about voice, representation and interpretive authority (Chase, 2005, p. 657; Genishi & Glupczynski, 2006, p. 671; Eisenhart, 2006. In essence, therefore, this paper is reflective of the challenges of “doing” qualitative research in educational settings. Its particular focus-the shaping of beginning primary teachers’ identities, in Ireland, throughout the course of their initial year of occupational experience, post-graduation- endeavours to highlight issues pertaining to the researcher as narrator (O’Sullivan, 2014.

  4. Voicing others’ voices: Spotlighting the researcher as narrator

    Directory of Open Access Journals (Sweden)

    Dan O'Sullivan

    2015-09-01

    Full Text Available As qualitative research undertakings are not independent of the researcher, the “indissoluble interrelationship between interpreter and interpretation” (Thomas & James, 2006, p. 782 renders it necessary for researchers to understand that their text is a representation, a version of the truth that is the product of writerly choices, and that it is discursive. Endlessly creative, artistic and political, as there is no single interpretative truth, the interpretative process facilitates the refashioning of representations, the remaking of choices and the probing of discourses. As a consequence of the particularity of any researcher’s account, issues pertaining to researcher identity and authorial stance always remain central to research endeavours (Kamler & Thomson, 2006, p. 68; Denzin & Lincoln 2011, pp. 14-15. Therefore, researchers are encouraged to be reflexive about their analyses and research accounts (Elliott, 2005, p. 152, as reflexivity helps spotlight the role of the researcher as narrator. In turn, spotlighting the researcher as narrator foregrounds a range of complex issues about voice, representation and interpretive authority (Chase, 2005, p. 657; Genishi & Glupczynski, 2006, p. 671; Eisenhart, 2006. In essence, therefore, this paper is reflective of the challenges of “doing” qualitative research in educational settings. Its particular focus-the shaping of beginning primary teachers’ identities, in Ireland, throughout the course of their initial year of occupational experience, post-graduation- endeavours to highlight issues pertaining to the researcher as narrator (O’Sullivan, 2014.

  5. Spotlighting quantum critical points via quantum correlations at finite temperatures

    International Nuclear Information System (INIS)

    Werlang, T.; Ribeiro, G. A. P.; Rigolin, Gustavo

    2011-01-01

    We extend the program initiated by T. Werlang et al. [Phys. Rev. Lett. 105, 095702 (2010)] in several directions. Firstly, we investigate how useful quantum correlations, such as entanglement and quantum discord, are in the detection of critical points of quantum phase transitions when the system is at finite temperatures. For that purpose we study several thermalized spin models in the thermodynamic limit, namely, the XXZ model, the XY model, and the Ising model, all of which with an external magnetic field. We compare the ability of quantum discord, entanglement, and some thermodynamic quantities to spotlight the quantum critical points for several different temperatures. Secondly, for some models we go beyond nearest neighbors and also study the behavior of entanglement and quantum discord for second nearest neighbors around the critical point at finite temperature. Finally, we furnish a more quantitative description of how good all these quantities are in spotlighting critical points of quantum phase transitions at finite T, bridging the gap between experimental data and those theoretical descriptions solely based on the unattainable absolute zero assumption.

  6. Estrategias de comercialización de las distribuidoras de productos de consumo masivo de la provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Nury Vera Campuzano

    2017-05-01

    The objective of the present scientific article is to diagnose the perception of the consumers of the distributors of products of mass consumption of the province of Santa Elena. The theoretical contribution lies in the conception of theory and practice in strategic marketing actions, taking into account the context, the definition and characterization of marketing management, in order to determine the decisive and success factors for the companies, constitutes the contribution Theoretical to argue the research carried out. An exploratory investigation was conducted for consumers of mass products between 20 and 54 years of Santa Elena province and interviews were conducted with three distributors of mass consumer products. The results recommend that with the application of assertive marketing strategies based on the preferences of the target group, and market trends, organizational performance would be improved by attracting prospects and generating loyalty ties of current clients.

  7. AEgIS at ELENA: outlook for physics with a pulsed cold antihydrogen beam.

    Science.gov (United States)

    Doser, M; Aghion, S; Amsler, C; Bonomi, G; Brusa, R S; Caccia, M; Caravita, R; Castelli, F; Cerchiari, G; Comparat, D; Consolati, G; Demetrio, A; Di Noto, L; Evans, C; Fanì, M; Ferragut, R; Fesel, J; Fontana, A; Gerber, S; Giammarchi, M; Gligorova, A; Guatieri, F; Haider, S; Hinterberger, A; Holmestad, H; Kellerbauer, A; Khalidova, O; Krasnický, D; Lagomarsino, V; Lansonneur, P; Lebrun, P; Malbrunot, C; Mariazzi, S; Marton, J; Matveev, V; Mazzotta, Z; Müller, S R; Nebbia, G; Nedelec, P; Oberthaler, M; Pacifico, N; Pagano, D; Penasa, L; Petracek, V; Prelz, F; Prevedelli, M; Rienaecker, B; Robert, J; Røhne, O M; Rotondi, A; Sandaker, H; Santoro, R; Smestad, L; Sorrentino, F; Testera, G; Tietje, I C; Widmann, E; Yzombard, P; Zimmer, C; Zmeskal, J; Zurlo, N

    2018-03-28

    The efficient production of cold antihydrogen atoms in particle traps at CERN's Antiproton Decelerator has opened up the possibility of performing direct measurements of the Earth's gravitational acceleration on purely antimatter bodies. The goal of the AEgIS collaboration is to measure the value of g for antimatter using a pulsed source of cold antihydrogen and a Moiré deflectometer/Talbot-Lau interferometer. The same antihydrogen beam is also very well suited to measuring precisely the ground-state hyperfine splitting of the anti-atom. The antihydrogen formation mechanism chosen by AEgIS is resonant charge exchange between cold antiprotons and Rydberg positronium. A series of technical developments regarding positrons and positronium (Ps formation in a dedicated room-temperature target, spectroscopy of the n =1-3 and n =3-15 transitions in Ps, Ps formation in a target at 10 K inside the 1 T magnetic field of the experiment) as well as antiprotons (high-efficiency trapping of [Formula: see text], radial compression to sub-millimetre radii of mixed [Formula: see text] plasmas in 1 T field, high-efficiency transfer of [Formula: see text] to the antihydrogen production trap using an in-flight launch and recapture procedure) were successfully implemented. Two further critical steps that are germane mainly to charge exchange formation of antihydrogen-cooling of antiprotons and formation of a beam of antihydrogen-are being addressed in parallel. The coming of ELENA will allow, in the very near future, the number of trappable antiprotons to be increased by more than a factor of 50. For the antihydrogen production scheme chosen by AEgIS, this will be reflected in a corresponding increase of produced antihydrogen atoms, leading to a significant reduction of measurement times and providing a path towards high-precision measurements.This article is part of the Theo Murphy meeting issue 'Antiproton physics in the ELENA era'. © 2018 The Author(s).

  8. ELENA GARRO, A DESHORA: FIGURAS LITERARIAS DE LA ABYECCIÓN

    Directory of Open Access Journals (Sweden)

    Meritxell Hernando Marsal

    2014-12-01

    Full Text Available The massacre of Tlatelolco in 1968 was the most bloody incident of Diaz Ordaz’s government in Mexico and promoted a severe process of persecution and repression of the student movement. One of its consequences was the suspicion of betrayal by Elena Garro of the movement’s intellectual authors. Since then, Garro embodied an abject character of collaboration, in constant harassment, leading to her exile during twenty years.This paper considers the implications of the accusation and the diagnosis of insanity that accompanies it. For some critics this insanity is redeemed in her literary work, which in this operation achieves prominence; but the insanity can be thought of as irreducible. Garro’s delirious gaze doesn’t sublimate the trauma, but repeats again and again the political violence, with harassed, exposed and out of place characters, in situations of daily totalitarianism. Figures of betrayal emerge in her histories, involving characters and knowledge outside the language of the official left (animal, children, women, the indigenous, marked by their helplessness and questioning the premises of political parties. 

  9. From Odessa to Florence: Elena Comparetti Raffalovich. A Jewish Russian Woman in Nineteenth-Century Italy

    Directory of Open Access Journals (Sweden)

    Asher Salah

    2015-11-01

    Full Text Available In the nineteenth and the first half of the twentieth century, Italy held a strong appeal for Russian travelers. Several of these Russian émigrés were women of Jewish lineage, who had come with their families or were sent abroad on their own in order to complete their education at one of the newborn kingdom’s prestigious universities. Elena Raffalovich (Odessa 1842 – Florence 1918 is one of the earliest and most intriguing examples of this phenomenon. While her intellectual trajectory, as a pioneer in children’s education and an advocate of women’s rights, is representative of that of many other Russian Jewish women living in Italy at that time, it also challenges a number of historiographic commonplaces about Jewish women and their emancipation process in nineteenth-century Europe. Moreover, through the archives of different prominent members of the Raffalovich dynasty, it is possible to follow its vicissitudes over at least five generations, completing our knowledge of Elena’s biography and reassessing the importance of her intellectual contribution to Italian culture.

  10. Plan de manejo integral del sitio arqueológico Santa Elena, Tabasco, México

    Directory of Open Access Journals (Sweden)

    Ernesto González Licón

    2013-11-01

    Full Text Available En este artículo se destaca la importancia histórica, cultural y turística del sitio arqueológico de Santa Elena, en el Estado de Tabasco, México. Mediante la ejecución de un proyecto de investigación arqueológica y Plan de Manejo Integral se pretende desarrollar todos estos aspectos para la recuperación del sitio y su entorno ecológico. Con la participación de los más amplios y diversos sectores públicos y privados interesados de los tres niveles de gobierno –federal, estatal y municipal–, se plantea el diseño de un Plan de manejo local y regional que permita el desarrollo sustentable de la zona y de su entorno para que sea abierta al público en general. Lo anterior será una fuente de información y conocimiento histórico, cultural, identitario y ecoturístico, que coadyuvará en el desarrollo integral de las comunidades actuales vecinas y cercanas.

  11. Plan de manejo integral del sitio arqueológico Santa Elena, Tabasco, México

    Directory of Open Access Journals (Sweden)

    Ernesto González Licón

    2013-12-01

    Full Text Available En este artículo se destaca la importancia histórica, cultural y turística del sitio arqueológico de Santa Elena, en el Estado de Tabasco, México. Mediante la ejecución de un proyecto de investigación arqueológica y Plan de Manejo Integral se pretende desarrollar todos estos aspectos para la recuperación del sitio y su entorno ecológico. Con la participación de los más amplios y diversos sectores públicos y privados interesados de los tres niveles de gobierno –federal, estatal y municipal–, se plantea el diseño de un Plan de manejo local y regional que permita el desarrollo sustentable de la zona y de su entorno para que sea abierta al público en general. Lo anterior será una fuente de información y conocimiento histórico, cultural, identitario y ecoturístico, que coadyuvará en el desarrollo integral de las comunidades actuales vecinas y cercanas.

  12. Research on Synthetic Aperture Radar Processing for the Spaceborne Sliding Spotlight Mode.

    Science.gov (United States)

    Shen, Shijian; Nie, Xin; Zhang, Xinggan

    2018-02-03

    Gaofen-3 (GF-3) is China' first C-band multi-polarization synthetic aperture radar (SAR) satellite, which also provides the sliding spotlight mode for the first time. Sliding-spotlight mode is a novel mode to realize imaging with not only high resolution, but also wide swath. Several key technologies for sliding spotlight mode in spaceborne SAR with high resolution are investigated in this paper, mainly including the imaging parameters, the methods of velocity estimation and ambiguity elimination, and the imaging algorithms. Based on the chosen Convolution BackProjection (CBP) and PFA (Polar Format Algorithm) imaging algorithms, a fast implementation method of CBP and a modified PFA method suitable for sliding spotlight mode are proposed, and the processing flows are derived in detail. Finally, the algorithms are validated by simulations and measured data.

  13. Research on Synthetic Aperture Radar Processing for the Spaceborne Sliding Spotlight Mode

    Directory of Open Access Journals (Sweden)

    Shijian Shen

    2018-02-01

    Full Text Available Gaofen-3 (GF-3 is China’ first C-band multi-polarization synthetic aperture radar (SAR satellite, which also provides the sliding spotlight mode for the first time. Sliding-spotlight mode is a novel mode to realize imaging with not only high resolution, but also wide swath. Several key technologies for sliding spotlight mode in spaceborne SAR with high resolution are investigated in this paper, mainly including the imaging parameters, the methods of velocity estimation and ambiguity elimination, and the imaging algorithms. Based on the chosen Convolution BackProjection (CBP and PFA (Polar Format Algorithm imaging algorithms, a fast implementation method of CBP and a modified PFA method suitable for sliding spotlight mode are proposed, and the processing flows are derived in detail. Finally, the algorithms are validated by simulations and measured data.

  14. COSMO-SkyMed Spotlight interometry over rural areas: the Slumgullion landslide in Colorado, USA

    Science.gov (United States)

    Milillo, Pietro; Fielding, Eric J.; Schulz, William H.; Delbridge, Brent; Burgmann, Roland

    2014-01-01

    In the last 7 years, spaceborne synthetic aperture radar (SAR) data with resolution of better than a meter acquired by satellites in spotlight mode offered an unprecedented improvement in SAR interferometry (InSAR). Most attention has been focused on monitoring urban areas and man-made infrastructure exploiting geometric accuracy, stability, and phase fidelity of the spotlight mode. In this paper, we explore the potential application of the COSMO-SkyMed® Spotlight mode to rural areas where decorrelation is substantial and rapidly increases with time. We focus on the rapid repeat times of as short as one day possible with the COSMO-SkyMed® constellation. We further present a qualitative analysis of spotlight interferometry over the Slumgullion landslide in southwest Colorado, which moves at rates of more than 1 cm/day.

  15. Identificación y Caracterización de Cepas Nativas de Rhizobium en la Provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Javier Soto

    2015-10-01

    Full Text Available En los sistemas agrícolas de subsistencia, el nitrógeno es un macronutriente esencial para el buen desarrollo de las plantas; es utilizado en forma de nitrato o amonio. Las bacterias del género Rhizobium poseen la capacidad de fijar el nitrógeno, mediante una relación de simbiosis con leguminosas e influyen en la producción de sustancias promotoras de crecimiento en las plantas no leguminosas. En la península de Santa Elena no existen evidencias del uso y aplicación de biofertilizantes de origen microbiano nativo, por lo que el presente trabajo tuvo como objetivo caracterizar y seleccionar cepas del género Rhizobium procedentes de los nódulos de leguminosas de dos zonas de la provincia de Santa Elena. Los experimentos Aislamiento, identificación y caracterización bioquímica de cepas de Rhizobium encontradas en diferentes zonas de la península de Santa Elena comprende: a Estudio de la morfología nodular de leguminosas; b Presencia de la enzima Leghemoglobina en los nódulos, c Aislamiento de microorganismos de los nódulos de leguminosas, d Respuesta de la enzima catalasa ante el peróxido de hidrógeno, e Crecimiento en diferentes fuentes de carbono , f Crecimiento en tres porcentajes cloruro de sodio; y e Producción de 3-ketolactasa en agar LLA para descartar contaminantes frecuentes como Agrobacterium.

  16. Análisis Estructural de Fallas Geológicas y Potenciales Deslizamientos en Anconcito, Provincia de Santa Elena

    OpenAIRE

    Kervin Chunga

    2015-01-01

    El sector costero de Anconcito, localizado al suroeste de la provincia de Santa Elena, es afectado por fenómenos geológicosinducidos por la dinámica costera de la zona de estudio: (1) socavamiento de los acantilados causado por la dinámica de la erosión marina y posterior derrumbe de estratos rocosos, y (2) deslizamientos de estratos rocosos a través de planos lístricosde fallas geológicas de tipo normal con componentes de desplazamientos laterales dextrales. El análisis estructural permitió ...

  17. Réquiem para María Elena: Notas sobre el imaginario de los últimos pampinos

    OpenAIRE

    Rodríguez T.,Juan Carlos; Miranda B.,Pablo; Mege R.,Pedro

    2005-01-01

    Este artículo refiere a la fuerza y la pervivencia de un imaginario de la pampa y de la cultura del salitre que se resiste a morir, pero que no encuentra referente en María Elena, el último pueblo salitrero. Tal imaginario, como acto compensatorio frente a la desestructuración de la comunidad y su identidad y que se refugia en elementos que no son sincrónicos en el actual espacio físico, laboral, psicológico, social, cultural y político del pueblo y sus habitantes, puede atrapar a antropólogo...

  18. The hELENa project - I. Stellar populations of early-type galaxies linked with local environment and galaxy mass

    OpenAIRE

    Sybilska, A.; Lisker, T.; Kuntschner, H.; Vazdekis, A.; van de Ven, G.; Peletier, R.; Falcón-Barroso, J.; Vijayaraghavan, R.; Janz, J.

    2017-01-01

    We present the first in a series of papers in T$h$e role of $E$nvironment in shaping $L$ow-mass $E$arly-type $N$earby g$a$laxies (hELENa) project. In this paper we combine our sample of 20 low-mass early types (dEs) with 258 massive early types (ETGs) from the ATLAS$^{\\mathrm{3D}}$ survey - all observed with the SAURON integral field unit (IFU) - to investigate early-type galaxies' stellar population scaling relations and the dependence of the population properties on local environment, exten...

  19. The Regina Elena National Cancer Institute process of accreditation according to the standards of the Organisation of European Cancer Institutes.

    Science.gov (United States)

    Canitano, Stefano; Di Turi, Annunziata; Caolo, Giuseppina; Pignatelli, Adriana C; Papa, Elena; Branca, Marta; Cerimele, Marina; De Maria, Ruggero

    2015-01-01

    The accreditation process is, on the one hand, a tool used to homogenize procedures, rendering comparable and standardized processes of care, and on the other, a methodology employed to develop a culture of quality improvement. Although not yet proven by evidence-based studies that health outcomes improve as a result of an accreditation to excellence, it is undeniable that better control of healthcare processes results in better quality and safety of diagnostic and therapeutic pathways. The Regina Elena National Cancer Institute underwent the accreditation process in accordance with the standards criteria set by the Organisation of European Cancer Institutes (OECI), and it has recently completed the process, acquiring its designation as a Comprehensive Cancer Center (CCC). This was an invaluable opportunity for the Regina Elena Institute to create a more cohesive environment, to widely establish a culture of quality, to implement an institutional information system, and to accelerate the process of patient involvement in strategic decisions. The steps of the process allowed us to evaluate the performance and the organization of the institute and put amendments in place designed to be adopted through 26 improvement actions. These actions regarded several aspects of the institute, including quality culture, information communication technology system, care, clinical trials unit, disease management team, nursing, and patient empowerment and involvement. Each area has a timeline. We chose to present the following 3 improvement actions: clinical trial center, computerized ambulatory medical record, and centrality of patient and humanization of clinical pathway.

  20. Dilemma in new clean and renewable energy alternatives for Santa Elena and its university. Opportunities and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Moreano, Hernan [Universidad Estatal Peninsula de Santa Elena (Ecuador). Inst. de Investigacion Cientifica y Desarrollo Tecnologico (INCYT)

    2011-07-01

    The fate of finite fossil fuel sources for the coming decades and the need to migrate to renewable energy in a joint effort among governments, academia and private companies which make business in the energy arena are discussed and also the energy balance in Ecuador which shows a strong dependence of fossil fuels to satisfy demand from both: thermoelectric plants and transport, however, Santa Elena, the newly created province at the south western of Ecuador has the chance to turn the country energy situation into an opportunity and face the challenge to be the leader in energy alternatives because of its resources and chances to migrate sooner to environmental friendly fuels and later on to renewable energies, but a number of actions should be taken in a joint effort with its local university (UPSE), government bodies and private companies in order to create the ''Campus of Energy Knowledge'' to carry out the program: Energy Alternatives for Santa Elena, which includes 7 projects to make the province a leader one on the energy issue in Ecuador and in the continent, acting on a cluster initiative scheme. (orig.)

  1. EVALUACIÓN PSICOSOCIAL DEL ADULTO MAYOR EN LA PROVINCIA DE SANTA ELENA. 2013

    Directory of Open Access Journals (Sweden)

    Jenny Sornoza

    2016-04-01

    Full Text Available Los adultos mayores constituyen un grupo poblacional significativo, que por tiempos ha estado desatendido, a pesar de que en el año 1990 se dicta la Ley del Anciano aún las personas mencionadas no gozan de todos los beneficios que contiene dicha ley ya que hasta la actualidad dicha ley no se aplica en su totalidad por falta de socialización, desconocimiento de sus beneficios e implementación de los espacios adecuados entre otras limitantes. El objetivo de la investigación fue el de Realizar una evaluación psicológica y social a los adultos mayores de la provincia en mención, tomando como muestras a las diferentes agrupaciones existentes en varias comunidades y cantones, para crear un modelo de evaluación integral para la optimización de la atención primaria de la salud geriátrica en la Provincia de Santa Elena, al igual que se pretende diseñar propuestas de trabajo que mejoren su condición de vida, puesto que es un sector generalmente abandonado y vulnerable con fácil tendencia a la depresión ; en este estudio participan docentes y estudiantes de la carrera de psicología, y el apoyo coordinado del Ministerio de Inclusión Económica y Social con sus organizaciones y agrupaciones quienes se constituyeron en población y muestra; se aplicó métodos cuantitativo y cualitativo para la evaluación el aspecto psicológico, funciones mentales, entorno familiar y social con la aplicación de los siguientes instrumentos: Mini Mental, Test de Funcionamiento Familiar, ficha social, test de autoestima, ansiedad y depresión, los mismos que nos permitieron comprender cada una de las áreas mencionadas para tener una mirada del contexto general de la población investigada. Entre los hallazgos más relevantes tenemos síntomas de depresión, sentimientos de inutilidad y expectativas de encontrar espacios en los que puedan sentirse productivos y a la vez ocupar su tiempo; así mismo soledad, percepción de abandono familiar entre otros.

  2. Paranoia y juegos fantásticos en Andamos huyendo Lola de Elena Garro

    Directory of Open Access Journals (Sweden)

    Raúl Calderón Bird

    2008-07-01

    Full Text Available La palabra griega paránoia se compone de pará (fuera de y de noys (mente. Traducida literalmente significa “fuera de la mente”, expresión que remite a su vez a la palabra “locura”. De hecho, esa holgada acepción es la primera que registra El pequeño Larousse en su edición de 2003. Sin embargo, la psiquiatría ha restringido su significado. Los psiquiatras Alfred M. Freedman, Harold I. Kaplan y Benjamin J. Sadock, en su Compendio de Psiquiatría, la definen como un trastorno psicótico crónico que se caracteriza por una alta frecuencia de ideas delirantes, y distinguen cuatro estados paranoides: el celotípico, el erótico, el de grandeza y el persecutorio. Pero advierten que de estos cuatro estados, “el estado persecutorio es clínicamente, con mucho, el más frecuente y el más importante”. Si damos por descontado que la literatura es en buena medida reflejo de la realidad, tanto exterior como interior, no es de extrañar que de esos cuatro estados paranoides acaso el más frecuente en dicho arte, y el más importante también, lo sea el estado persecutorio paranoide. Pensando en la literatura hispanoamericana contemporánea, por lo menos dos escritores de la misma generación produjeron ficciones de corte autobiográfico con fuertes tintes de ese estadoparanoide: el argentino Ernesto Sábato en Abbadón el extermina- dor, novela publicada en 1974, y la mexicana Elena Garro en los cuen- tos y novelas que escribió algún tiempo después de 1968, sobre todo, y empezando por el título mismo, en el libro de cuentos que nos ocupará en el presente artículo, Andamos huyendo Lola, publicado en 1980.

  3. Methane Dynamics in a Tropical Serpentinizing Environment: The Santa Elena Ophiolite, Costa Rica

    Directory of Open Access Journals (Sweden)

    Melitza Crespo-Medina

    2017-05-01

    Full Text Available Uplifted ultramafic rocks represent an important vector for the transfer of carbon and reducing power from the deep subsurface into the biosphere and potentially support microbial life through serpentinization. This process has a strong influence upon the production of hydrogen and methane, which can be subsequently consumed by microbial communities. The Santa Elena Ophiolite (SEO on the northwestern Pacific coast of Costa Rica comprises ~250 km2 of ultramafic rocks and mafic associations. The climatic conditions, consisting of strongly contrasting wet and dry seasons, make the SEO a unique hydrogeological setting, where water-rock reactions are enhanced by large storm events (up to 200 mm in a single storm. Previous work on hyperalkaline spring fluids collected within the SEO has identified the presence of microorganisms potentially involved in hydrogen, methane, and methanol oxidation (such as Hydrogenophaga, Methylobacterium, and Methylibium spp., respectively, as well as the presence of methanogenic Archaea (such as Methanobacterium. Similar organisms have also been documented at other serpentinizing sites, however their functions have not been confirmed. SEO's hyperalkaline springs have elevated methane concentrations, ranging from 145 to 900 μM, in comparison to the background concentrations (<0.3 μM. The presence and potential activity of microorganisms involved in methane cycling in serpentinization-influenced fluids from different sites within the SEO were investigated using molecular, geochemical, and modeling approaches. These results were combined to elucidate the bioenergetically favorable methane production and/or oxidation reactions in this tropical serpentinizing environment. The hyperalkaline springs at SEO contain a greater proportion of Archaea and methanogens than has been detected in any terrestrial serpentinizing system. Archaea involved in methanogenesis and anaerobic methane oxidation accounted from 40 to 90% of total

  4. EL MANEJO COSTERO INTEGRADO COMO PROBLEMA DE INVESTIGACIÓN TRANSDISCIPLINARIO EN LA UNIVERSIDAD PENÍNSULA DE SANTA ELENA.

    Directory of Open Access Journals (Sweden)

    Vladimir Soria

    2016-04-01

    Full Text Available La investigación generativa es uno de los dominios sobre los cuales las universidades deben mostrar fortalezas para justificar su pertinencia y permanencia en el sistema ecuatoriano de educación superior. En enfoque transdisciplinario o de orquestación de ciencias se ha mostrado como el más apreciado dentro de la actual modelo de universidad, y una propuesta válida para responder a dicha exigencia es el estudio del manejo costero integrado como eje transversal dentro de la Universidad Estatal Península de Santa Elena. A través de la literatura científica se ha estudiado el manejo costero integrado como una forma de gobernanza ambiental cuyo origen se encuentra en los documentos generados en la Cumbre de la Tierra de Río de Janeiro en el año 1992. Dentro de la provincia de Santa Elena el Manejo Costero Integrado busca incidir en dos aspectos: fortalecimiento institucional y participación ciudadana. El deficiente control ambiental en la faja costera existente exige un modelo de gestión a escala local basado en tres ejes: el fortalecimiento de las capacidades institucionales de las instituciones públicas desconcentradas; el ordenamiento territorial para una adecuada determinación y delimitación de las competencias en materia ambiental costera; y la participación ciudadana a nivel del régimen de las comunas en coordinación con los distintos niveles de gobierno. Se propone articular la investigación en la materia tanto a nivel interdisciplinario como interinstitucional, coordinando agendas de investigación de las instituciones públicas y privadas con las estrategias de los distintos actores políticos involucrados en el desarrollo sustentable de las zonas costeras. Finalmente se presentan los resultados preliminares de una investigación que se ha iniciado en la Facultad de Ciencias Administrativas sobre las características específicas de cada comuna ubicada en la faja costera para posteriormente proponer para cada una de ellas

  5. Estudio de factibilidad de procesadora de derivados de maracuyá. Una alternativa de desarrollo en Santa Elena, Ecuador Autores

    Directory of Open Access Journals (Sweden)

    Tigrero-González, Félix

    2016-04-01

    Full Text Available The present study aims to determine the technical and financial feasibility of processing derived products from passion fruit, through the setting–up of a production and marketing company in the commune “Las Balsas” - Santa Elena city, Guayas province, Ecuador, where the company will be located. This place has a geographical and climatological location that is appropriate for the growing of passion fruit which facilitates obtaining raw materials throughout the year. The social impact of the company is positive since it demands workers for its operation which will be found in the same sector, plus the use of clean technology for environmen- tal conservation, besides the test of a hypothesis that the setting–up of a processing plant of passion fruit will generate social and economic benefits that allows a better standard of life of the inhabitants of this commune and province.

  6. Comportamiento Agronómico de seis variedades de Cebada (Hordeum Vulgare en tres localidades, Provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Néstor Orrala B

    2015-10-01

    Full Text Available En la península de Santa Elena de mayo a diciembre, las temperaturas giran alrededor de 22 ºC, , lo que podría ser un medio adecuado para muchos cultivos andinos. El estudio exploratorio tuvo como objetivo verificar el comportamiento agronómico de variedades de cebada: Terán, Cañicapa 03, Clipper , Grit, Metcalfe y Scarlett en tres ambientes de la provincia de Santa Elena. Variables evaluadas: germinación, ahijamiento, encañado, espigado, maduración, altura de planta, número de macollos, longitud de espiga, cantidad de granos llenos y vanos, peso 1 000 semillas, rendimiento por hectárea, más análisis económico. Los resultados concluyen que las etapas fenológicas son más cortas en la Costa que en la Sierra, pudiéndose afirmar que el ciclo vegetativo de los germoplasmas está determinado por la interacción genotipo-ambiente y por las características varietales de cada cultivar. Las variedades Metcalfe, Scarlett y Clipper alcanzan rendimientos entre 3,55 y 4,35 toneladas por hectárea. El costo de producción por hectárea es mayor con relación a la sierra, lo que se explica en el mayor uso del recurso agua.Palabras claves: Cebada, comportamiento, variedades, épocas, adaptación.

  7. Benito Fernández de Elena Garro: una mirada crítica sobre la historia mexicana

    Directory of Open Access Journals (Sweden)

    Gerardo Bustamante Bermúdez

    2017-07-01

    Full Text Available En 1957, Elena Garro escribió la obra teatral Benito Fernández, texto en el que hace una revisión crítica a la historia nacional, el poder, la simulación y la búsqueda de la identidad personal en medio de la sociedad creada a partir de la posrevolución mexicana. La obra de la escritora es un contradiscurso a la oficialidad, a la mitificación de los hechos y héroes nacionales; lo que le interesa es resaltar el carácter racista y clasista de una nueva sociedad de dirigentes políticos en busca del bienestar personal y de grupo por encima del bien colectivo, para ello, opta porque en su obra los personajes se preocupen por comprar una cabeza, es decir, una ideología que les haga saber que existen. In 1957, Elena Garro wrote the play Benito Fernández, a text in which she critically reviews Mexico's national history, issues of power, simulation and the quest for personal identity in the midst of a society emerged in the after effects of the Mexican Revolution. This work is a counter-discourse to Mexico's official narrative and the idealization of facts and national heroes. She is interested in the racist and classist aspects of the new dominating society, which is interested in their own personal welfare over those of the collective. To do so, she makes her characters concerned about buying a head, that is, an ideology to fundament their own existence.

  8. Diarrhea & Child Care: Controlling Diarrhea in Out-of-Home Child Care. NCEDL Spotlights, No. 4.

    Science.gov (United States)

    Churchill, Robin B.; Pickering, Larry K.

    This report, the fourth in the National Center for Early Development and Learning's (NCEDL) "Spotlights" series, is based on excerpts from a paper presented during a "Research into Practice in Infant/Toddler Care" synthesis conference in fall 1997. The report addresses controlling diarrhea in out-of-home child care. The report…

  9. Freeform TIR collimators for the removal of angular color variation in white LED spotlights

    NARCIS (Netherlands)

    Prins, C.R.; Schneider, C.; IJzerman, W.L.; Tukker, T.W.; Thije Boonkkamp, ten J.H.M.; Winston, R.; Gordon, J.

    2013-01-01

    Angular color variation in white, phosphor-converted LEDs causes undesirable yellow rings in the beams of spotlights. We developed an inverse method to design TIR collimators that remove the angular color variation for point light sources and significantly reduce color variation for extended light

  10. Electrostatic protocol treatment lens. The purpose of this device is to transport Antiprotons from the new ELENA storage beam to all AD experiments. The electrostatic device was successfully tested in ASACUSA two weeks ago.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    Electrostatic protocol treatment lens. The purpose of this device is to transport Antiprotons from the new ELENA storage beam to all AD experiments. The electrostatic device was successfully tested in ASACUSA two weeks ago.

  11. INCIDENCIA DE LOS SISTEMAS DE CONTROL CONTABLE EN LA GESTION ADMINISTRATIVA DE LAS EMPRESAS PRIVADAS EN LA PROVINCIA DE SANTA ELENA AÑO 2014

    OpenAIRE

    Karina Bricio; Carol Caamaño

    2016-01-01

    La presente investigaciones tiene como objetivo evaluar la incidencia de los  sistemas de control contable en la gestion administrativa de las emoresas privadas en la provincia de Santa Elena, el proyecto está enmarcado dentro del área de gestion administrativa, comunicación organizacional, control contable, informes financieros, control de registros contables, entre otros, se han venido desarrollando desde hace años los procesos administrativos de una manera manual y se han implementadi sist...

  12. The EU environmental-energy policy for urban areas: The Covenant of Mayors, the ELENA program and the role of ESCos

    International Nuclear Information System (INIS)

    Lombardi, Mariarosaria; Pazienza, Pasquale; Rana, Roberto

    2016-01-01

    The Covenant of Mayors (CoM) is an initiative of the European Commission started in 2008 with the aim of involving cities more in the implementation of the 20-20-20 climate-energy package. To this end, a variety of tools to assist the realization of such a policy has been built. The European Local Energy Assistance (ELENA) program of the European Investment Bank (EIB) is one of the most relevant. In this work, we observe some data on the Italian participation in the CoM and ELENA program, while highlighting the role the Energy Service Companies have in these contexts. By referring to the specific experience of the Province of Foggia (an intermediary government body in southern Italy), we also discuss how some recent changes in the Italian legislation, aimed at abolishing the provinces (considered as preferred supporting structure of the CoM), imposed the identification of another supraterritorial entity. This is to substitute the Province of Foggia as coordinator in the dialog between the local territory and the European Union institutions on the climate-energy theme. In this sense, the choice of the Chamber of Commerce represents a novelty. With regard to this, some considerations on the appropriateness of this choice are developed. - Highlights: •The CoM is an EU environmental-energy initiative for local authorities. •The ELENA program supports technical energy efficiency activities within the CoM. •Chambers of Commerce can usefully coordinate ELENA projects submission. •Public bodies are committed to implement energy saving projects on their buildings. •The ESCOs develop and implement energy efficiency projects.

  13. Is There any Relationship Between the Santa Elena Depression and Chicxulub Impact Crater, Northwestern Yucatan Peninsula, Mexico?

    Science.gov (United States)

    Lefticariu, L.

    2005-05-01

    The Terminal Cretaceous Chicxulub Impact Crater had a strong control on the depositional and diagenetic history of the northern Yucatan Platform during most of the Cenozoic Era. The Chicxulub Sedimentary Basin (henceforth Basin), which approximately coincides with the impact crater, is circumscribed by a concentration of karstic sinkholes known as the Ring of Cenotes. Santa Elena Depression (henceforth Depression) is the name proposed for the bowl-shaped buried feature, first contoured by geophysical studies, immediately south of the Basin, in the area where the Ticul 1 and UNAM 5 wells were drilled. Lithologic, petrographic, and biostratigraphic data on PEMEX, UNAM, and ICDP cores show that: 1) Cenozoic deposits are much thicker inside the Basin than inside the Depression, 2) in general, the Cenozoic formations from inside the Depression are the thickest among those outside the Basin, 3) variably dolomitized pelagic or outer-platform wackestone or mudstone occur both inside the Basin and Depression, 4) the age of the deeper-water sedimentary carbonate rocks is Paleocene-Eocene inside the Basin and Paleocene?-Early Eocene inside the Depression, 5) the oldest formations that crop out are of Middle Eocene age at the edge of the Basin and Early-Middle Eocene age inside the Depression, 6) saline lake deposits, that consist chiefly of anhydrite, gypsum, and fine carbonate, and also contain quartz, chert, clay, zeolite, potassium feldspar, pyrite, and fragments of wood, are present in the Cenozoic section of the UNAM 5 core between 282 and 198 m below the present land surface, 7) the dolomite, subaerial exposure features (subaerial crusts, vugs, karst, dedolomite), and vug-filling cement from the Eocene formations are more abundant inside the Depression than inside the Basin. The depositional environments that are proposed for explaining the Cenozoic facies succession within the Santa Elena Depression are: 1) deeper marine water (Paleocene?-Early Eocene), 2) relatively

  14. Efecto de la inoculación de bacterias nativas en dos híbridos de maíz (zea mays l., provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Javier Soto

    2016-11-01

    Full Text Available En la actualidad la mayoría de los sistemas de producción agrícola están sobrecargados con residuos de insumos químicos que aceleran el desgaste del suelo y contaminan las fuentes de agua subterránea. Siendo una alternativa el empleo de biofermentos provenientes de bacterias nativas de la rizosfera, muy conocidas por la producción de sustancias promotoras de crecimiento vegetal (PGPR y de resistencia a ciertos patógenos. En el presente trabajo se seleccionaron y emplearon tres cepas bacterianas (FPMG2, FPMG4 y VAIRV asociadas a nódulos de leguminosas de la península de Santa Elena de la colección CIAP-UPSE (Centro de Investigaciones Agropecuarias de la Universidad Estatal Península de Santa Elena, con potencial uso para la elaboración de biofertilizantes en plantas no leguminosas y de importancia alimenticia como el maíz (Zea mays L.; evaluando la influencia de los híbridos AGRI 104 y 201 en la germinación (a nivel de laboratorio y campo, cultivo y rendimiento en dos fincas agrícolas en la provincia de Santa Elena-Ecuador.

  15. Citrato de Calcio a partir de valvas de ostras en la Península de Santa Elena-Ecuador

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    Mery Ramírez

    2016-04-01

    Full Text Available Las valvas de ostras (Crassostrea iridescens son un desecho de la actividad gastronómica local de la Provincia de Santa Elena. Con el propósito de otorgar un valor agregado a estos desperdicios el grupo integrado por los estudiantes y la Docente de Química de Ciencias del Mar de la Universidad Estatal de la Península de Santa Elena (UPSE, han puesto en marcha un proyecto en el contexto de una economía diversificada a través del conocimiento, la innovación social y tecnológica, base de la nueva matriz productiva de Ecuador [1]. Investigaciones realizadas por China y Japón [2] han ideado formas de reutilizar las propiedades calcáreas de las valvas de las ostras, conociendo que el calcio es suplemento en alimentos y medicinas de uso terapéutico y medicinal [3] [4]. El presente estudio se realizó con un total de 200 valvas de ostras, con una longitud promedio de 10,5 cm, recolectadas periódicamente, permitiendo cumplir con características fundamentales del análisis químico, y el desarrollo de habilidades de investigación en los estudiantes. El porcentaje de Calcio presente en las valvas fue cuantificado mediante técnicas de tratamiento de muestras y análisis químico: limpieza, secado, pulverizado y extracción mediante lixiviación ácida para la precipitación y cuantificación de compuestos indeseables [5]. La metodología es seleccionada de acuerdo a la disposición de equipamiento del Laboratorio de Ciencias Químicas (UPSE. Los resultados indicaron que las valvas de ostras contenían un porcentaje de materia inorgánica de 99,16%, donde el calcio representó el 10.17%.También se evaluaron los elementos trazas ajenos como parte de aseguramiento de la calidad del producto obtenido. La técnica permite obtener el Calcio en forma de Citrato de calcio con buenos porcentajes de aceptabilidad química. Estos resultados estimulan el desarrollo de futuras investigaciones, que posibiliten la explotación económica de este residuo en

  16. DETERMINACION DE FACTORES DE RIESGO DE MOBBING EN LAS EMPRESAS ESTATALES DE LA PROVINCIA DE SANTA ELENA

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    Bertha Maggi De Monserrate

    2016-04-01

    Full Text Available El Mobbing es una patalogía considerada por la Organizacion Mundial de la Salud y la Organizacion Panamericana como una entidad clinica muy violenta que en los ultimos dias ha tomado un auge considerable afectando el desarrollo de las naciones y constituyendo una amenaza para la salud publica a nivel mundial. Este término proviene del vocablo anglosajón que se traduce como acoso moral, psicoterror laboral, violencia psicológica, en resumen una medida de conducta agresiva hacia el trabajador victima, por parte de otro trabajador agresor. Los especialistas coinciden en que se trata de un problema de salud publica, alcanzando el grado de epidemia - pandemia. El objetivo de proyecto es determinar los factores de riesgo que inducen al Mobbing en los trabajadores de los Establecimientos Estatales de la Provincia de Santa Elena, en una muestra al azar de 400 trabajadores. El instrumento de Recoleccion de datos será el Inventario de Acoso Moral de Leyman. El resultado será diagnostico de Mobbing en los trabajadorobjeto de estudio para la intervención psicológica respectiva.

  17. The hELENa project - II. Abundance distribution trends of early-type galaxies: from dwarfs to giants

    Science.gov (United States)

    Sybilska, A.; Kuntschner, H.; van de Ven, G.; Vazdekis, A.; Falcón-Barroso, J.; Peletier, R. F.; Lisker, T.

    2018-06-01

    In this second paper of The role of Environment in shaping Low-mass Early-type Nearby galaxies (hELENa) series we study [Mg/Fe] abundance distribution trends of early-type galaxies (ETGs) observed with the Spectrographic Areal Unit for Research on Optical Nebulae integral field unit, spanning a wide range in mass and local environment densities: 20 low-mass early types (dEs) of Sybilska et al. and 258 massive early types (ETGs) of the ATLAS3D project, all homogeneously reduced and analysed. We show that the [Mg/Fe] ratios scale with velocity dispersion (σ) at fixed [Fe/H] and that they evolve with [Fe/H] along similar paths for all early types, grouped in bins of increasing local and global σ, as well as the second velocity moment Vrms, indicating a common inside-out formation pattern. We then place our dEs on the [Mg/Fe] versus [Fe/H] diagram of Local Group galaxies and show that dEs occupy the same region and show a similar trend line slope in the diagram as the high-metallicity stars of the Milky Way and the Large Magellanic Cloud. This finding extends the similar trend found for dwarf spheroidal versus dwarf irregular galaxies and supports the notion that dEs have evolved from late-type galaxies that have lost their gas at a point of their evolution, which likely coincided with them entering denser environments.

  18. El estilo de apego en la violencia contra la mujer, en la provincia de Santa Elena, Ecuador.

    Directory of Open Access Journals (Sweden)

    Holguer Romero

    2015-10-01

    The objective is to determine the style of attachment S. What influences the permission of Violence against Women, evaluating the type of violence, which is prevalent in the Province of Santa Elena, in women assaulted by their romantic partners. Analysis Unit is violated That woman accepts Be Part of the Study By signing the Informed Consent. The UN is Metodo JOINT Focus: Comparative correlational, with a quasi-experimental design ex post facto, on the basis of Mixed Media: research based on observation. Information Sera primary and secondary source, the focus is Quantitative and qualitative interview technique employing one profundity and filling the questionnaires. Risk scale Apostolic Violence, CaMir Questionnaire. The personological Features Each with Data Analysis Report of the expert analyzes, para establish A triangulation With The Other Instruments results. With the evaluation of the type of violence, verifying attachment style, Determined The reasons for this addiction abused woman, With obtaining affective-cognitive characteristics; facilitate the evaluation is diagnosed expert, benefiting Rescue of Victims of Violence.

  19. A leading-edge hardware family for diagnostics applications and low-level RF in CERN's ELENA ring

    CERN Document Server

    Angoletta, M E; Jaussi, M; Leiononen, P; Levens, T E; Molendijk, J C; Sanchez-Quesada, J; Simonin, J

    2013-01-01

    The CERN Extra Low ENergy Antiproton (ELENA) Ring is a new synchrotron that will be commissioned in 2016 to further decelerate the antiprotons transferred from the CERN’s Antiproton Decelerator (AD). The requirements for the acquisition and treatment of signals for longitudinal diagnostics are very demanding, owing to the revolution frequency swing as well as to the digital signal processing required. The requirements for the Low-Level Radio-Frequency (LLRF) system are very demanding as well, especially in terms of revolution frequency swing, dynamic range and low noise required by the cavity voltage control and digital signal processing to be performed. Both sets of requirements will be satisfied by using a leading-edge hardware family, developed to cover the LLRF needs of all synchrotrons in the Meyrin site; it will be first deployed in 2014 in the CERN’s PSB and in the medical machine MedAustron. This paper gives an overview of the main building blocks of the hardware family and of th...

  20. Herramientas de Marketing y Gerenciales que se emplean en las diferentes Unidades de Negocios de la provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Roxana Álvarez

    2015-10-01

    The company like cell of the economy has to be studied because it turns in actor of the first order. The good health of the company is the good health of the economic one and vice versa. The company is what his manager is; the person interests then brain of the organization. Inside this context this study is realized in search of the organization and activity of the company of the province of Santa Elena. It has been considered so much of marketing a set of variables as managerial that use these units of production and / or commercialization for the attainment of his aims: positioning and economic growth. There takes a sample that includes the most wide business range: companies of retail and wholesale commercialization, of services, of commercialization, of production and of another type. The information obtains across surveys, which then are tabulated, which allows to obtain the tools that use the business in the province. The companies declare the utilization of tools, but his administrators cannot explain form and the procedures in each of the cases, that is to say, do it of intuitive form, more not because they possess the technical knowledge of the same ones.

  1. Adaptación del Trigo (Triticum, en diferentes épocas de cuatro localidades, Provincia de Santa Elena.

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    Néstor Orrala B

    2015-10-01

    Full Text Available EL Ecuador importa el 98 % de los requerimientos internos de trigo. Tradicionalmente se cultiva en la Sierra, cuya clima tiene características parecidas a la provincia de Santa Elena en determinada época, lo que podría ser soporte para adaptar este cultivar a las condiciones agroecológicas de la península. La investigación tuvo objetivo verificar el comportamiento agronómico de variedades de trigo en San Vicente de Colonche, Sinchal, Zapotal, San Vicente de Loja con los materiales Cojitambo, Zhalao, Trigo Blanco, Seri-Atila y Tinamou x Lira x Veree, sembradas en diferentes épocas bajo el diseño Bloques Completamente al Azar. Variables experimentales estudiadas: encañado, espigado, altura de la planta, número de macollos; longitud de espiga sin aristas; cantidad de granos llenos y vanos; peso de 1 000 semillas, expresado en gramos; rendimiento por hectárea en kilogramos mas análisis económico. Las etapas fenológicas son más cortas en la Costa con relación a la Sierra; sobresale la localidad San Vicente de Colonche, la primera época y la variedad Zhalao. Algunas variables agronómicas se acercan a los descriptores del INIAP.

  2. The hELENa project - I. Stellar populations of early-type galaxies linked with local environment and galaxy mass

    Science.gov (United States)

    Sybilska, A.; Lisker, T.; Kuntschner, H.; Vazdekis, A.; van de Ven, G.; Peletier, R.; Falcón-Barroso, J.; Vijayaraghavan, R.; Janz, J.

    2017-09-01

    We present the first in a series of papers in The role of Environment in shaping Low-mass Early-type Nearby galaxies (hELENa) project. In this paper, we combine our sample of 20 low-mass early types (dEs) with 258 massive early types (ETGs) from the ATLAS3D survey - all observed with the SAURON integral field unit - to investigate early-type galaxies' stellar population scaling relations and the dependence of the population properties on local environment, extended to the low-σ regime of dEs. The ages in our sample show more scatter at lower σ values, indicative of less massive galaxies being affected by the environment to a higher degree. The shape of the age-σ relations for cluster versus non-cluster galaxies suggests that cluster environment speeds up the placing of galaxies on the red sequence. While the scaling relations are tighter for cluster than for the field/group objects, we find no evidence for a difference in average population characteristics of the two samples. We investigate the properties of our sample in the Virgo cluster as a function of number density (rather than simple clustrocentric distance) and find that dE ages correlate with the local density such that galaxies in regions of lower density are younger, likely because they are later arrivals to the cluster or have experienced less pre-processing in groups, and consequently used up their gas reservoir more recently. Overall, dE properties correlate more strongly with density than those of massive ETGs, which was expected as less massive galaxies are more susceptible to external influences.

  3. Characterizing the nature of melt-rock reaction in peridotites from the Santa Elena Ophiolite, NW Costa Rica

    Science.gov (United States)

    Carr, D.; Loocke, M. P.; Snow, J. E.; Gazel, E.

    2017-12-01

    The Santa Elena Ophiolite (SEO), located on the northwestern coast of Costa Rica, consists primarily of preserved oceanic mantle and crustal rocks thrust above an accretionary complex. The SEO is predominantly characterized by mantle peridotites (i.e., primarily spinel lherzolite with minor amounts of harzburgite and dunite) cut and intruded by minor pegmatitic gabbros, layered gabbros, plagiogranites, and doleritic and basaltic dykes. Previous studies have concluded that the complex formed in a suprasubduction zone (SSZ) setting based on the geochemical nature of the layered gabbros and plagiogranites (i.e., depleted LREE and HFSE and enriched LILE and Pb), as well, as the peridotites (i.e., low-TiO2, Zr, and V, and high MgO, Cr, and Ni)(Denyer and Gazel, 2009). Eighteen ultramafic samples collected during the winter 2010/2011 field season (SECR11) exhibit abundant evidence for melt-rock reaction (e.g., disseminated plagioclase and plagioclase-spinel, clinopyroxene-spinel, and plagioclase-clinopyroxene symplectites) and provide a unique opportunity to characterize the textural and chemical nature of melt-rock reaction in the SEO. We present the results of a petrologic investigation (i.e., petrography and electron probe microanalysis) of 28 thin sections (19 spinel lherzolites, of which 14 are plagioclase-bearing, 4 pyroxenite veins, and 5 harzburgites) derived from the SECR11 sample set. The results of this investigation have the potential to better our understanding of the nature of melt generation and migration and melt-rock interaction in the SEO mantle section and shed further light on the complex petrogenetic history of the SEO. Denyer, P., Gazel, E., 2009, Journal of South American Earth Sciences, 28:429-442.

  4. Los juegos tradicionales se han perdido en la memoria cultural actual de los niños y niñas de la provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Patricia Ortega Ramírez

    2016-06-01

    Full Text Available El presente trabajo de investigación se inicio en la Península de Santa Elena, pues es ahí donde nació nuestra cultura ancestral. Nuestro propósito fue confirmar la hipótesis de si los niños y niñas aún participan en actividades lúdicas ancestrales. Se seleccionaron quince comunas de la Provincia de Santa Elena (La Entrada, Olón, Montañita, Dos Mangas, Sacachún, Cadeate, Salinas, Ancón, Atahualpa, Valdivia, Libertador Bolívar, El Tambo, San Vicente, Ayangue y Santa Elena a fin de realizar el estudio, se aplicaron encuestas, se realizaron entrevistas, se escucharon referencias de vida, y se observaron actividades de juego. Los resultados de las encuestas nos dicen que efectivamente un gran porcentaje de niños y niñas ya no conocen ni practican juegos ancestrales, algunos ni siquiera los conocen. Este trabajo pretende que los niños y niñas de las comunas en las que se realizó la investigación disfruten participando en los juegos con los que también se divirtieron sus antepasados, donde además ejercitaran sus habilidades y destrezas, que les permitirá estimular su imaginación y creatividad, fisicamente potenciaran el desarrollo de su esquema corporal y psíquicamente sus emociones, aprenderán a través del juego a sentirse orgullosos de su linaje, de sus raíces y de su tradición.

  5. DISPONIBILIDAD DE RAÍCES ADVENTICIAS DE TRES ESPECIES SILVESTRES COSECHADAS PARA LA ELABORACIÓN DE ARTESANÍAS EN SANTA ELENA, ANTIOQUIA (COLOMBIA

    Directory of Open Access Journals (Sweden)

    ANA MARÍA BENAVIDES

    2015-01-01

    Full Text Available En los Andes colombianos, un gran número de artesanías se fabrican a partir de raíces adventicias de plantas nativas que crecen de forma silvestre. Sin embargo, la deforestación y las prácticas no sustentables han diezmado la disponibilidad de plantas silvestres productoras de fibra. En este estudio evaluamos la disponibilidad de fibras de tres especies en Santa Elena (Antioquia, Colombia: Asplundia sarmentosa, Philodendron aff. sagittifolium y Clusia multiflora. Después de una búsqueda exhaustiva en la zona de estudio ubicamos menos de 30 individuos adultos de cada especie. Para cada planta se midieron las variables asociadas al tamaño de la planta y se registró el número y la longitud de raíces maduras e inmaduras. Se pesaron fragmentos de raíces para estimar la biomasa. El crecimiento de raíces de cada planta fue monitoreado mensualmente durante siete meses. La disponibilidad actual de fibra (raíces maduras es de ca. 3 352 m (Asplundia 1 481 m, Clusia de 952 m, Philodendron 918 m, con esta cantidad de material se pueden elaborar entre 419 a 838 canastos. De acuerdo a la tasa de crecimiento mensual, una nueva raíz podría alcanzar un tamaño para ser cosechado entre el mes 38 y 71. Plantas más grandes tienen mayor cantidad de raíces maduras, sin embargo, la tasa de crecimiento no está asociada al tamaño de la planta. Nuestros resultados proveen evidencia de que las plantas en Santa Elena presentan una relación (tamaño de la planta, número de raíces maduras que es similar a plantas que se encuentran en zonas no intervenidas, no obstante, la cosecha de fibras en Santa Elena no es una actividad sostenible debido al bajo número de individuos susceptibles de ser cosechados, la lenta tasa de crecimiento de raíces y la alta demanda de fibras. Es necesario implementar estrategias como el enriquecimiento del bosque con estas tres especies para garantizar una actividad sustentable para recolectores y artesanos en Santa Elena y

  6. Incidencia de la inteligencia competitiva en el desarrollo económico de las empresas de la provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Nathyn Collins Ventura

    2017-05-01

    Full Text Available El objetivo de este artículo fue analizar la incidencia de la inteligencia competitiva en el desarrollo económico de las empresas. La inteligencia competitiva ayuda a las empresas a definir y conocer la industria, así como a identificar las fortalezas y debilidades de sus rivales, lo que incluye actividades de inteligencia para reunir datos sobre los competidores e interpretarlo; si se hace correctamente, ayuda a la compañía a evitar sorpresas porque se anticipan los movimientos de los competidores y se disminuye el tiempo de respuesta. Se implementó una investigación exploratoria correlacional para poder diagnosticar el desempeño organizacional de las empresas de la provincia de Santa Elena. Los métodos implementados son deductivo e inductivo, mediante técnicas de observación descriptiva, entrevistas a gerentes de las empresas y encuestas a trabajadores de las empresas para conocer la situación real. Se seleccionó 32 empresas de la provincia de Santa Elena en las que se efectuaron entrevistas a gerentes. Los resultados demuestran que, con la potenciación de fortalezas de la empresa, y por ende el aprovechamiento de oportunidades del entorno, se generará un desarrollo económico de la empresa que implemente acciones sólidas y oportunas.   Abstract The objective of this article was to analyze the incidence of competitive intelligence in the economic development of companies. Competitive intelligence helps companies define and know the industry, as well as identify the strengths and weaknesses of their rivals, which includes intelligence activities to gather data about competitors and interpret it; If done correctly, helps the company to avoid surprises because they anticipate the movements of competitors and decreases the response time. An exploratory correlational research was implemented to diagnose the organizational performance of companies in the province of Santa Elena. The methods implemented are deductive and inductive

  7. LA ASOCIATIVIDAD DEL SECTOR PESQUERO ARTESANAL DEL CANTÓN LA LIBERTAD, PROVINCIA DE SANTA ELENA Y LA INCIDENCIA EN SU CALIDAD DE VIDA, EN 2013”

    OpenAIRE

    León Sinche, Irene Paulina

    2017-01-01

    La presente investigación muestra el desarrollo y aplicación de un modelo asociativo para mejorar la calidad de vida de los pescadores artesanales del cantón La Libertad, provincia de Santa Elena, cuyo proceso se inicia con la investigación objetiva de la situación actual del sector, mediante la aplicación de métodos, técnicas e instrumentos de investigación para conocer los datos demográficos de los pescadores artesanales, acceso al crédito y el nivel de asociatividad desarrol...

  8. Importance of lunar and temporal conditions for spotlight surveys of adult black-footed ferrets

    Science.gov (United States)

    Eads, David A.; Jachowski, David S.; Millspaugh, Joshua J.; Biggins, Dean E.

    2012-01-01

    Black-footed ferrets (Mustela nigripes) spend most daylight hours underground in prairie dog (Cynomys) burrows and exhibit aboveground movements primarily at night. Moonlight can influence the activity patterns of ferrets and, consequently, might influence the efficiency of spotlight surveys used by biologists to monitor ferret populations. We related detection of adult ferrets during postbreeding spotlight surveys to lunar and temporal conditions. We most frequently located ferrets during surveys in which the moon breached the horizon. The data suggested intersexual differences in response to moonlight. We located male ferrets most frequently during nights with greater moon illumination, but we did not detect a correlation between moon illumination and spotlight detection of female ferrets. In general, moonlight could facilitate aboveground navigation by ferrets. However, it seems activity under bright moonlight could be costly for female ferrets while they raise young. Detection of ferrets also varied among months. We detected female ferrets most frequently in August–September, when mothers increase hunting efforts to acquire prey for growing offspring (kits). Detection of adult female ferrets declined in October, when kits were likely independent of their mother. We located male ferrets most frequently in September–October, when males might increase activity to monitor female ferrets and male competitors. Consideration of lunar and temporal influences and standardization of postbreeding surveys could enhance site-specific assessment of reintroduction success and across-site assessment of species recoveiy progress. We suggest that postbreeding surveys for ferrets should be enhanced by concentrating efforts in August–September during moonlit nights when the moon is above the horizon.

  9. Mejoras productivas en el tratamiento de Paja Toquilla en el Centro de Tratamiento de Paja Toquilla de la comuna Barcelona, parroquia Manglaralto, provincia de Santa Elena, Ecuador.

    Directory of Open Access Journals (Sweden)

    Jorge Lucin

    2015-10-01

    The community of Barcelona, parish ManglaraltoCantón Santa Elena, is known for its treatment of the straw shawl floor (Carludovicapalmata. In its acres of land in the mountains adjacent to the Chongón-Colonche range, this plant grows wild it is harvested in about three years of cultivation. In the village, families headed by women workers, performing the treatment plant for cleaning, cooking, drying and packaging processes, which will be directed to areas in the country where they make the famous Panama hats. In order to improve the process of this treatment, the NOBS group, The Provincial Council of Santa Elena and PORAMÉRICA,   have signed a cooperation agreement that has managed to achieve the objectives. The drying process, which was a problem in times of lack of sun, has been solved with installation of industrial dryers and simultaneously marginalized cooking process and do it with wood stove, achieving efficiency in this process with the use of burners with industrial gas, lowering environmental impact. The administrative process improved with the implementation of documents and control of the production process and costs.

  10. Observatorio turístico: Una herramienta de gestión para el turismo de sol y playa en la provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Efren Mendoza

    2016-12-01

    Tourism in the province of Santa Elena has become a sector of great importance, which has been not only supported by government policies, but also by initiatives of businessmen and communities. Tourism planning has become the best tool for successful and sustainable development of the activity aiming towards the objectives set in the National Plan for Good Living, by following the guidelines established by PLANDETUR (Strategic Development Plan for Sustainable Tourism in Ecuador 2020, while accepting at the same time, the recommendations based on reality where tourism arises. One of the tangible needs is based on the lack of reliable information available about the characteristics of the demand in respect to the Sun and Beach tourism offer; which is the leading product of the province.  This data is significant to support decision-making for each of the actors that make up this vast sector.  This paper shows some results obtained in the investigation through the application of actions taken to design a tourist observatory targeted to the Sun and Beach tourism in Santa Elena, and monitored through the establishment of a base for the guidelines of a management system for tourism information, and by the establishment of the profile of domestic demand.

  11. Sulfur and carbon geochemistry of the Santa Elena peridotites: Comparing oceanic and continental processes during peridotite alteration

    Science.gov (United States)

    Schwarzenbach, Esther M.; Gill, Benjamin C.; Gazel, Esteban; Madrigal, Pilar

    2016-05-01

    Ultramafic rocks exposed on the continent serve as a window into oceanic and continental processes of water-peridotite interaction, so called serpentinization. In both environments there are active carbon and sulfur cycles that contain abiogenic and biogenic processes, which are eventually imprinted in the geochemical signatures of the basement rocks and the calcite and magnesite deposits associated with fluids that issue from these systems. Here, we present the carbon and sulfur geochemistry of ultramafic rocks and carbonate deposits from the Santa Elena ophiolite in Costa Rica. The aim of this study is to leverage the geochemistry of the ultramafic sequence and associated deposits to distinguish between processes that were dominant during ocean floor alteration and those dominant during low-temperature, continental water-peridotite interaction. The peridotites are variably serpentinized with total sulfur concentrations up to 877 ppm that is typically dominated by sulfide over sulfate. With the exception of one sample the ultramafic rocks are characterized by positive δ34Ssulfide (up to + 23.1‰) and δ34Ssulfate values (up to + 35.0‰). Carbon contents in the peridotites are low and are isotopically distinct from typical oceanic serpentinites. In particular, δ13C of the inorganic carbon suggests that the carbon is not derived from seawater, but rather the product of the interaction of meteoric water with the ultramafic rocks. In contrast, the sulfur isotope data from sulfide minerals in the peridotites preserve evidence for interaction with a hydrothermal fluid. Specifically, they indicate closed system abiogenic sulfate reduction suggesting that oceanic serpentinization occurred with limited input of seawater. Overall, the geochemical signatures preserve evidence for both oceanic and continental water-rock interaction with the majority of carbon (and possibly sulfate) being incorporated during continental water-rock interaction. Furthermore, there is

  12. Book review, Animali da compagnia: tutele – diritti – responsabilità, Elena Bassoli (a cura di

    Directory of Open Access Journals (Sweden)

    Manuel Graziani

    2012-12-01

    Full Text Available L'avvocato, docente universitario e presidente dell'Associazione Nazionale Giuristi Informatici e Forensi, Elena Bassoli, ha curato un manuale che affronta le problematiche relative ai diritti degli animali, approfondendo prima la legislazione internazionale e poi le singole pieghe di quella italiana. Il dato da cui si parte sembra secondario ma, invero, è assai rilevante, ovvero che nel nostro Paese si è passati molto lentamente da una concezione esclusivamente utilitaristica degli animali (tutelati in quanto proprietà di qualcuno all'affermazione dei diritti propri dell'animale in quanto tale.Animali da compagnia: tutele – diritti – responsabilità è utile soprattutto alla luce dei Trattati internazionali (D.U.D.A., Trattato di Amsterdam, Trattato di Lisbona che nel corso degli anni hanno introdotto la tutela dell'animale nelle legislazioni di tutto il mondo. La curatrice e i collaboratori hanno analizzato la recente giurisprudenza sugli animali da compagnia e le varie fonti del diritto nazionale, europeo e internazionale, passando in rassegna le norme di riferimento e indicandone l'applicabilità e le procedure con il fine dichiarato di: "Offrire al lettore uno strumento utile, rigoroso e scritto in modo chiaro e comprensibile anche per chi, per la prima volta, si trovi ad affrontare questa parte del diritto". Il manuale si presenta precipuamente come uno strumento di lavoro per i professionisti che trattano le problematiche relative al mondo degli animali domestici. Va segnalata, in proposito, la chiarezza non solo nell'esposizione dei concetti ma anche nell'architettura editoriale. I 10 capitoli che lo compongono forniscono un inquadramento sistematico delle implicazioni amministrative e penali, con rimandi a diverse note per una maggiore chiarezza del testo: dalle origini del diritto animale (dall'antica Grecia all'animalismo contemporaneo, con in mezzo Medioevo, Rinascimento e Darwinismo passando alla tutela degli animali nell

  13. Scientist Spotlight Homework Assignments Shift Students’ Stereotypes of Scientists and Enhance Science Identity in a Diverse Introductory Science Class

    Science.gov (United States)

    Schinske, Jeffrey N.; Perkins, Heather; Snyder, Amanda; Wyer, Mary

    2016-01-01

    Research into science identity, stereotype threat, and possible selves suggests a lack of diverse representations of scientists could impede traditionally underserved students from persisting and succeeding in science. We evaluated a series of metacognitive homework assignments (“Scientist Spotlights”) that featured counterstereotypical examples of scientists in an introductory biology class at a diverse community college. Scientist Spotlights additionally served as tools for content coverage, as scientists were selected to match topics covered each week. We analyzed beginning- and end-of-course essays completed by students during each of five courses with Scientist Spotlights and two courses with equivalent homework assignments that lacked connections to the stories of diverse scientists. Students completing Scientist Spotlights shifted toward counterstereotypical descriptions of scientists and conveyed an enhanced ability to personally relate to scientists following the intervention. Longitudinal data suggested these shifts were maintained 6 months after the completion of the course. Analyses further uncovered correlations between these shifts, interest in science, and course grades. As Scientist Spotlights require very little class time and complement existing curricula, they represent a promising tool for enhancing science identity, shifting stereotypes, and connecting content to issues of equity and diversity in a broad range of STEM classrooms. PMID:27587856

  14. Hospitality and Inclusion Logistics of a Spotlight Event: An Insiders Look at the 2016 DNC in Philadelphia

    Directory of Open Access Journals (Sweden)

    Leora Halpern Lanz

    2016-10-01

    Full Text Available The 2016 Democratic National Convention held in Philadelphia, Pennsylvania prioritized hospitality efforts and incorporated inclusion and diversity as its theme. These strategies helped to create a successful spotlight event, benefiting the city of Philadelphia and its hospitality industry.

  15. Alaska: Improving Referrals of Victims of Maltreatment to the IDEA Part C Program. State Spotlight: Data Sharing

    Science.gov (United States)

    Derrington, Taletha; Peters, Mary Louise; Mauzy, Denise; Ruggiero, Robert

    2015-01-01

    This 2015 state spotlight document describes how Alaska Part C improved the referral of children from Child Welfare to the Individuals with Disabilities Education Act (IDEA) Part C Program by an automated transfer of data from Child Welfare to Part C for substantiated cases of child maltreatment (i.e., child abuse and/or neglect).

  16. Scientist Spotlight Homework Assignments Shift Students' Stereotypes of Scientists and Enhance Science Identity in a Diverse Introductory Science Class

    Science.gov (United States)

    Schinske, Jeffrey N.; Perkins, Heather; Snyder, Amanda; Wyer, Mary

    2016-01-01

    Research into science identity, stereotype threat, and possible selves suggests a lack of diverse representations of scientists could impede traditionally underserved students from persisting and succeeding in science. We evaluated a series of metacognitive homework assignments ("Scientist Spotlights") that featured counterstereotypical…

  17. José María Díez Borque, dir., Álvaro Bustos Táuler and Elena Di Pinto Revuelta, eds., Hacia el gracioso: Comicidad en el teatro español del siglo XVI

    Directory of Open Access Journals (Sweden)

    Jesús Gómez

    2015-01-01

    Full Text Available Review of José María Díez Borque, dir., Álvaro Bustos Táuler and Elena Di Pinto Revuelta, eds., Hacia el gracioso: Comicidad en el teatro español del siglo XVI, Visor Libros, Madrid, 2014, 236 pp. ISBN: 9788498951547.

  18. Scientist Spotlight Homework Assignments Shift Students' Stereotypes of Scientists and Enhance Science Identity in a Diverse Introductory Science Class.

    Science.gov (United States)

    Schinske, Jeffrey N; Perkins, Heather; Snyder, Amanda; Wyer, Mary

    2016-01-01

    Research into science identity, stereotype threat, and possible selves suggests a lack of diverse representations of scientists could impede traditionally underserved students from persisting and succeeding in science. We evaluated a series of metacognitive homework assignments ("Scientist Spotlights") that featured counterstereotypical examples of scientists in an introductory biology class at a diverse community college. Scientist Spotlights additionally served as tools for content coverage, as scientists were selected to match topics covered each week. We analyzed beginning- and end-of-course essays completed by students during each of five courses with Scientist Spotlights and two courses with equivalent homework assignments that lacked connections to the stories of diverse scientists. Students completing Scientist Spotlights shifted toward counterstereotypical descriptions of scientists and conveyed an enhanced ability to personally relate to scientists following the intervention. Longitudinal data suggested these shifts were maintained 6 months after the completion of the course. Analyses further uncovered correlations between these shifts, interest in science, and course grades. As Scientist Spotlights require very little class time and complement existing curricula, they represent a promising tool for enhancing science identity, shifting stereotypes, and connecting content to issues of equity and diversity in a broad range of STEM classrooms. © 2016 J. N. Schinske et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  19. A Sta. Elena Experience

    International Development Research Centre (IDRC) Digital Library (Canada)

    fajardojp

    development programs, projects and activities that will effectively benefit a locality. ... We conducted the Training Workshop on Data collection in May of 2003 ..... percent or a total of 1750 unemployed of the 12,357 labor force population.

  20. Sustainable prevention of obesity through integrated strategies: The SPOTLIGHT project’s conceptual framework and design

    Directory of Open Access Journals (Sweden)

    Lakerveld Jeroen

    2012-09-01

    Full Text Available Abstract Background The prevalence of overweight and obesity in Europe is high. It is a major cause of the overall rates of many of the main chronic (or non communicable diseases in this region and is characterized by an unequal socio-economic distribution within the population. Obesity is largely determined by modifiable lifestyle behaviours such as low physical activity levels, sedentary behaviour and consumption of energy dense diets. It is increasingly being recognised that effective responses must go beyond interventions that only focus on a specific individual, social or environmental level and instead embrace system-based multi-level intervention approaches that address both the individual and environment. The EU-funded project “sustainable prevention of obesity through integrated strategies” (SPOTLIGHT aims to increase and combine knowledge on the wide range of determinants of obesity in a systematic way, and to identify multi-level intervention approaches that are strong in terms of Reach, Efficacy, Adoption, Implementation and Maintenance (RE-AIM. Methods/Design SPOTLIGHT comprises a series of systematic reviews on: individual-level predictors of success in behaviour change obesity interventions; social and physical environmental determinants of obesity; and on the RE-AIM of multi-level interventions. An interactive web-atlas of currently running multi-level interventions will be developed, and enhancing and impeding factors for implementation will be described. At the neighbourhood level, these elements will inform the development of methods to assess obesogenicity of diverse environments, using remote imaging techniques linked to geographic information systems. The validity of these methods will be evaluated using data from surveys of health and lifestyles of adults residing in the neighbourhoods surveyed. At both the micro- and macro-levels (national and international the different physical, economical, political and socio

  1. Pakistan. Spotlight.

    Science.gov (United States)

    Greene, M

    1985-01-01

    Focus in this discussion of Pakistan is on demographic factors, the issue of ethnic versus national solidarity, and economic and social development. The population was estimated at 99.2 million in 1985. The birthrate was 43/1000 in 1984 and the deaths were 15/1000. The infant mortality rate is 105 infant deaths/1000 live births, and life expectancy at birth is 51 years. In 1983 the gross national product per capita was US$390. The population of Pakistan is concentrated around Karachi on the Arabian Sea and in the crescent formed by Lahore, Rawalpindi, and Peshawar. Pakistan was a British colony, part of the Indian subcontinent until partition in 1947, when Britain gave Pakistan and India their freedom. Pakistan is not a theocracy, but the military government turns to traditional Islam for affirmation of its authority. Its martial law regime, established in 1977, is headed by President Ziaul Haq. The issue of ethnic versus national solidarity has been a problem since independence. Bengali-speaking East Pakistanis felt they did not have equal power in their country whose official language was Urdu and whose capital was in West Pakistan. East and West Pakistan ended up in armed conflict with the formation of Bangladesh in 1971 as the result. Regional and ethnic conflict is exacerbated by the low rate of literacy and the low status of certain ethnic groups in Pakistan. In addition, Pakistan suffers problems typical of many developing nations: a low per capita income, a large and growing population, and a highly stratified traditional society. In 1981 doctors, engineers, and craftsmen were in short supply, but there was a surplus of 300,000 agricultural workers. Agriculture makes up 30% of the GNP and employs 55% of the work force. In Pakistan's 6th Five Year Plan, initiated in July 1983, the government acknowledged for the 1st time the extremely poor conditions for women as indicated by literacy, health, and fertility. The total fertility rate is 6.4 average births/woman. Although the government is ostensibly trying to help women, funding for women's programs during the Five Year Plan was cut. Economic growth has been good in recent years, but agricultural growth is a result of increased acreage rather than yield per acre.

  2. Spotlight: Ecuador.

    Science.gov (United States)

    1998-04-01

    This article describes the vital statistics and population growth in Ecuador as of mid-1997. Mid-1997 population numbered about 12 million. Fertility was 3.6 births/woman; deaths were 6/1000 population; and births were 29/1000 population. Ecuador was primarily an agricultural country, until oil was discovered in the early 1970s. The country has worked to increase per capita income and confront environmental consequences. The capital city of Quito is situated in a valley between two mountains and has very high air pollution levels due to cars and factories. In contrast, indigenous populations live in the Andean mountains and farm small plots. Land shortages have pushed these farmers onto higher slopes and more marginal land that is becoming eroded. 22% of Ecuador's forests were cleared for farming during 1980-90. The city of Guayaquil, on the Pacific coast, has serious water pollution problems, sewage problems, and industrial pollution. Shrimp farming relies on high levels of fertilizer, which is damaging coastlines. Oil exploration in the interior of Ecuador, has resulted in disruption of indigenous population, loss of forests, and pollution of rivers. Texaco Oil is accused of spilling about 17 million gallons of crude oil, or 50 times more than the Exxon Valdez oil spill in Alaska. Texaco argues that it met government environmental standards and agreed to a cleanup, which only partially meets the standards of its critics. Oil resources have funded improvements in education and health. About 90% of Ecuador's adult population is literate. Fertility has declined, but the population is still largely young and will be entering their reproductive years by 2025.

  3. Spotlight: Peru.

    Science.gov (United States)

    Yacher, L

    1985-09-01

    This article highlights population statistics from Peru, the 3rd largest country in Latin America. The population in 1985 has been estimated at 19.7 million. In 1982, the birth rate was 35/1000 and the mortality rate was 10/1000. Infant mortality stood at 99/1000 live births and life expectancy at birth was 59 years. 41% of Peru's population is under 15 years of age, and only 4% is 65 years of age or older. The country's total fertility rate is 5.2 births/woman. Only 0.4% of the population is foreign born. Peru is highly urbanized, and 65% of the country's total population growth in 1981 occurred in its cities. 1 in 3 Peruvians resides in the capital city of Lima. The 2 largest racial groups are mestizos and whites (53%) and Indians (46%). 21% of the population is illiterate. 40.7% of the labor force is employed in agriculture; however, only 15% of the national income is derived from agriculture. The GNP per capita was US$1040 in 1983. The country's economy is in serious trouble at present, with an annual inflation rate of 250% and a foreign debt of US$13.5 billion.

  4. Spotlight: Togo.

    Science.gov (United States)

    May, J F

    1988-12-01

    The Republic of Togo is a land of 21,622 square miles on the west coast of Africa, 8 degrees north of the equator. The country is divided between the Kabye people in the north (22%) and the Ewe people in the south (35%). The president, General Gnassingbe Eyadema, is a Kabye. The population of 3.3 million (1988) is growing at the rate of 3.3%/year, despite an infant mortality of 107 deaths/1000 live births and a life expectancy of only 54 years. The total fertility rate is 6.5 children/woman. The birth rate is 47 births/1000 population, and the death rate is 14/1000. Population growth, especially in the cities of Lome and Kara, where 1/4 of the population lives, is considered a major threat to development. A Demographic and Health Survey has been taken, and a Conference on Population and Development was held in Lome in 1987 to draft a national population policy statement. Family planning services need to be implemented to raise the contraceptive prevalence rate above its present 2%, and the population needs to be redistributed, but this requires investment of funds currently being used to service the foreign debt. The country's gross national product is only $300 per capita.

  5. Spotlight: Malaysia.

    Science.gov (United States)

    Patriquin, W

    1988-03-01

    Focus is on Malaysia -- its population and land area, its total fertility rate and mortality rate, economic development, contraceptive usage, and population policy. In 1987 Malaysia's population was estimated to be 16.1 million with births 31/1000 population and deaths 7/1000 population. The rate of natural increase is 2.4%, the total fertility rate 3.9 children/woman, and the infant mortality rate 30/1000 live births. Ethnically, Malaysia is made up of several distinct groups. Indigenous Malays are the most numerous -- about 50% of the population. Their unique characteristics include that they are Moslem, rural, and usually of lower economic status. Chinese make up the 2nd largest group of Malaysians, nearly 1/3 of the population. This group is active in trade, business, and finance and possesses considerable economic power. About 10% of the population is of Indian descent. Malaysia has experienced much economic growth. Traditional exports grew in volume and value during the 1970; the petroleum sector expanded so rapidly it accounts for 1/4 of all exports. One reason for Malaysia's rapid economic growth is the government's promotion of industrialization and foreign investment. According to the 1982 contraceptive prevalence survey, 42% of currently married women 15-44 years were using contraception. The government considers the current rate of national increase to be satisfactory, but in 1984 it adopted a population policy to more than quadruple its population in 2100 to 70 million. It intends to accomplish this by instituting pronatalist incentives to help the fall in the national growth rate. The government's rationale for more population growth is that a larger domestic population could better support industrial growth that otherwise might be stymied by "protectionist policies practiced by developed countries." Incentives to encourage fertility include income-tax deductions and maternity benefits for women who have up to 5 children.

  6. Spotlight: Bangladesh.

    Science.gov (United States)

    Parikh, L

    1998-01-01

    This brief article highlights the progress made in Bangladesh in reducing fertility and improving women's status. The mid-1997 population was an estimated 122.2 million persons. The land area is 50,260 square miles. Population density was 2432 people per square mile. Births were 31 per 1000 persons. Deaths were 11 per 1000 persons. Infant deaths were 77 per 1000 live births. Natural increase was 2% per year. The total fertility rate was 3.3 births per woman. Life expectancy was 58 years for males and females. Bangladesh is one of the most densely populated countries in the world and has about 50% of US population situated on land the size of Wisconsin. Average annual income is about $240. Livelihoods from agriculture are affected by monsoons and natural disasters. Bangladesh has reduced its fertility by half since the mid-1970s. Almost 50% of married women relied on contraception during 1996-97, compared to only 8% of married women in 1975. Increases in contraceptive prevalence are attributed to the family planning program and parents' desire for smaller families. The government has made slowing population growth a priority since the 1970s. The 35,000 field workers provide door-to-door contraception and counseling. Mass media has promoted messages about the economic and health advantages of limiting or spacing births. Women continue to play a subordinate role to men, despite their improved control over fertility. Under 30% of women are literate compared to 50% of men. Islamic practices still confine women to the home. Programs are directed to improving women's financial status through credit programs. Women now hold many jobs in the new garment industry, which is the largest nonagricultural employer.

  7. Spotlight: Azerbaijan.

    Science.gov (United States)

    1999-02-01

    As of mid-1998, Azerbaijan had a population of 7.7 million people residing in a land area of 33,436 square miles. There were 17 births and 6 deaths per 1000 population, as well as 19 infant deaths for every 1000 live births, and a population growing in size at 1.1% annually. The average woman had 2.1 births during her reproductive lifetime and life expectancy was 67 years for men and 74 years for women. Azerbaijan is an oil-producing country, although the agricultural sector is responsible for 25% of gross domestic product and employs 31% of the work force. Despite its oil wealth and strong agricultural and mining sectors, Azerbaijan is struggling to improve its environmental conditions and support a large refugee population. The country's air, water, and soil are severely polluted. Air pollution stems from petrochemical plants, refineries, exhaust fumes, and the burning of untreated garbage; water pollution is the result of oil spills, leaky pipelines and tanks, runoff of fertilizers and pesticides, and improperly treated sewage; and land pollution is due to inadequate waste management. The high incidence of waterborne diseases, including cholera, in Azerbaijan is caused by the inadequate treatment of drinking water and sewage intrusion into leaky distribution pipes. Although over 90% of infants under age 1 year are immunized against diphtheria, whooping cough, tetanus, polio, and measles, babies in Azerbaijan are 3 times as likely to die before reaching age 1 year than are babies in the US. Azerbaijani children are 5 times more likely to die by age 5 than are US children. Living conditions are especially difficult for the 12% of the overall population which are refugees.

  8. Iran: spotlight.

    Science.gov (United States)

    Roudi, N

    1987-09-01

    Given its location between Asia and Asia Minor, Iran has been a country of strategic political importance throughout history. More than 98% of Iran's population is Moslem. During the early 20th century, as Iran gradually gained independence from the USSR and Turkey, a modernization process was begun. However, this modernization process was forced to yield to Islamic traditionalism after the 1979 Islamic Revolution. Women have been most affected by this change. The implementation of Islamic traditions has meant low job opportunity or motivation for continuing education among women. Although fertility remains high, the present government is satisfied with the current rate of population growth. Family planning is allowed if implemented within the framework of Islamic law, but abortion is illegal. Mortality fell substantially after World War II, but has not continued to decline. At present, both males and females have the same life expectancy at birth. Iran's population is growing at a rate of 4%/year, and can be expected to double in another 21 years. It has been projected that Iran, currently the 21st largest country in the world with a population of 50 million, will become the 15th largest with a population of 97 million by the year 2025. Tehran, the 20th largest city in 1985, is projected to be the 9th largest by the year 2000, with a population of 13.6 million.

  9. A Spotlight on Chemical Constituents and Pharmacological Activities of Nigella glandulifera Freyn et Sint Seeds

    Directory of Open Access Journals (Sweden)

    Besma Boubertakh

    2013-01-01

    Full Text Available Plants belonging to the Ranunculaceae family, and particularly their seeds, have been a hot research topic in numerous pharmacognosy laboratories. Nigella glandulifera Freyn et Sint (NG is one of the promising, but relatively insufficiently studied, plants from this family. In this review, we summarize the recently isolated chemical constituents from the seeds of this plant including alkaloids, flavonol glycosides, isobenzofuranone derivatives, saponins, terpenes, terpenoids, and fatty acids. We put also a spotlight on the recently studied therapeutic potentials of such amazing herb seeds as antidiabetes, melanogenesis inhibition, anticancer, anti-inflammatory, antithrombosis, and antiplatelet aggregation effects. Herein, we illustrate certain properties and potentials via selected examples, and thus we suggest more studies to confirm the therapeutic hypotheses, find out new compounds, and eventually to discover novel properties.

  10. Coordinación de las protecciones de la subestación de distribución en la península de Santa Elena

    OpenAIRE

    Fernández Chicas, Robinson David; Espinel Encalada, José Leonidas; Aguilar Sánchez, Yasmani Leonardo; Saavedra Mera, Juan

    2014-01-01

    El presente trabajo desarrolla el estudio de la coordinación de protecciones aplicados a la subestación de distribución “SALINAS”, ubicada en la península de Santa Elena. Partiendo primero desde la descripción de las instalaciones, para conocer los elementos que la componen; posteriormente, se realiza un estudio de flujo de carga en condiciones de máxima y mínima carga y un estudio de cortocircuito de la subestación aplicados a la barra de 69kV y 13.8kV, esto nos servirá como datos preliminar...

  11. The Spotlight activity: Development and feasibility test of a naturalistic attention-redirection well-being intervention

    Directory of Open Access Journals (Sweden)

    Lilian Shin

    2018-03-01

    Full Text Available Positive activities, such as savoring, gratitude, and optimism, have been shown to boost positive emotions and reduce negative emotions. We argue that a shared mechanism driving their well-being benefits is the redirection of attention. In this feasibility study, we develop and pilot-test this mechanism with a novel positive activity intervention, the “spotlight activity,” that taught participants how to become mindful of where their attention was and to redirect it as needed. Individuals (initial N = 108 were randomly assigned to a 5-week spotlight activity intervention or to a waitlist control group and were assessed on measures of psychological well-being, need satisfaction, and hassles and uplifts. Preliminary results showed that, at post-test, the spotlight group reported significantly higher life satisfaction, meaning in life, and general weekly affect, as well as significantly lower negative affect and hassle intensity. The study provided initial evidence for the feasibility of a novel attention-redirection intervention and its potential to increase psychological well-being.

  12. Global Monitoring of Mountain Glaciers Using High-Resolution Spotlight Imaging from the International Space Station

    Science.gov (United States)

    Donnellan, A.; Green, J. J.; Bills, B. G.; Goguen, J.; Ansar, A.; Knight, R. L.; Hallet, B.; Scambos, T. A.; Thompson, L. G.; Morin, P. J.

    2013-12-01

    Mountain glaciers around the world are retreating rapidly, contributing about 20% to present-day sea level rise. Numerous studies have shown that mountain glaciers are sensitive to global environmental change. Temperate-latitude glaciers and snowpack provide water for over 1 billion people. Glaciers are a resource for irrigation and hydroelectric power, but also pose flood and avalanche hazards. Accurate mass balance assessments have been made for only 280 glaciers, yet there are over 130,000 in the World Glacier Inventory. The rate of glacier retreat or advance can be highly variable, is poorly sampled, and inadequately understood. Liquid water from ice front lakes, rain, melt, or sea water and debris from rocks, dust, or pollution interact with glacier ice often leading to an amplification of warming and further melting. Many mountain glaciers undergo rapid and episodic events that greatly change their mass balance or extent but are sparsely documented. Events include calving, outburst floods, opening of crevasses, or iceberg motion. Spaceborne high-resolution spotlight optical imaging provides a means of clarifying the relationship between the health of mountain glaciers and global environmental change. Digital elevation models (DEMs) can be constructed from a series of images from a range of perspectives collected by staring at a target during a satellite overpass. It is possible to collect imagery for 1800 targets per month in the ×56° latitude range, construct high-resolution DEMs, and monitor changes in high detail over time with a high-resolution optical telescope mounted on the International Space Station (ISS). Snow and ice type, age, and maturity can be inferred from different color bands as well as distribution of liquid water. Texture, roughness, albedo, and debris distribution can be estimated by measuring bidirectional reflectance distribution functions (BRDF) and reflectance intensity as a function of viewing angle. The non-sun-synchronous orbit

  13. Efecto de variante de riego en la producción de maíz (zea mays l. En la Comuna Río Verde, cantón Santa Elena, Ecuador.

    Directory of Open Access Journals (Sweden)

    Ángel León

    2016-11-01

    Effect of irrigation variant in the corn production (Zea mays L. at Río Verde commune, Santa Elena, Ecuador. The test was conducted at the Production and Practice Center Río Verde, owned by the Santa Elena Peninsula State University, located in Río Verde commune, Santa Elena canton, the research aimed to evaluate the effect of irrigation variations into agronomic performance of corn under different irrigation sheets using as measuring tool evaporation A class Pan. The treatments were five doses of irrigation 60, 70, 80, 90 and 100% of evapotranspiration, treatments were placed in a complete randomized design of blocks with four replications, the averages compared with the Tukey test (p> 0.05. The regression analysis fits a quadratic equation and the coefficient of determination R2 0,91 which shows the high degree of dependence of results based on irrigation variants. The highest production was obtained by the treatment with 90% with 12,18 t.ha-1.

  14. María Elena: el fin de una experiencia urbana: Un estudio de caso en el desierto de Atacama, Chile

    Directory of Open Access Journals (Sweden)

    JUAN CARLOS RODRÍGUEZ TORRENT

    2009-08-01

    Full Text Available En el presente trabajo se plantea la relación entre la ciudad salitrera de María Elena (II Región, diseñada de acuerdo a propuestas utópicas en un territorio privado, y el cambio de las relaciones laborales entre la Compañía SQM y los trabajadores a partir del predominio de un nuevo modelo de acumulación cuyos ejes están dados por la competitividad, la producción de calidad y la globalización. La ciudad fue creada para que hombres y mujeres construyeran sus proyectos de vida en medio del Desierto de Atacama, ofreciéndoles todas las garantías y la infraestructura para que ello fuese así en los marcos de una política de pleno empleo, de modo de contener a la población en un medio inhóspito, cumplir los objetivos productivos y fortalecer una identidad coherente y cohesionada, lo que a partir de nuevas decisiones estratégicas es substituido por un modelo de flexibilidad laboral, lo que anula su definición primigenia y el interés colectivo para comenzar a dar paso a un campamento minero.In this paper we look into the relationship between the nitrate town of Maria Elena (in Region II - designed on Utopian principals as a private project - and the changing labor relations between the SQM Company and the workers as a result of the predominance of a new accumulation model guided by competitiveness, quality production and globalization. The town was created so that men and women could establish their livelihoods in the Atacama Desert, with guarantees and infrastructure based on a full employment policy. This was in order to anchor the population in this inhospitable environment, to meet production objectives and to strengthen a coherent and cohesive identity. New strategic decisions led to this model being replaced by one based on labour flexibilization, deleting its original intention and collective interest to give way to a mining camp.

  15. Estudio sobre la Salud y Nutrición de los Estudiantes de la Universidad Estatal Península de Santa Elena

    Directory of Open Access Journals (Sweden)

    Karina Bricio

    2015-10-01

    A good physical activity with a good performance in all environments depends on the nutritious habits and good health that this represents, In fact universities today care about the quality of the education and keeping its healthy students; which is part of the teaching activities also having obligation to inculcate healthy habits within their study programs, and thereby to promote a healthy lifestyle. The objective of this research is to analyze which is the current state of health, and the types of foods consumed by the students of the state university of Santa Elena Peninsula UPSE, to determine strategies and to be able to implement campaigns and talks about health and nutrition. The investigation determined that the students are not feeding well, due to the fact that their diets do not incorporate, fruits, vegetable, and not taking any vitamin supplement, in addition it is analyzed that have a high stress problem, and generally are always suffering from gastritis. The diet should be balanced which these provides a positive balance to our body.

  16. Energía Undimotriz, alternativa para la producción de Energía Eléctrica en la Provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Rolando Calero

    2015-10-01

    Full Text Available La energía undimotriz, es la energía que permite obtener electricidad a partir de energía mecánica generada por el movimiento de las olas. Es uno de los tipos de energías renovables con más recientes estudios, y presenta enormes ventajas frente a otras energías renovables debido a que se tendría mayor facilidad para predecir condiciones geológicas óptimas que permitan la mayor eficiencia en sus procesos. Debido a que es más fácil llegar a predecir condiciones óptimas de oleaje, en comparación con la obtenida con  los vientos para obtener energía eólica, donde su variabilidad es menor.En este trabajo se espera aportar y dilucidar con datosespecíficos sobre la morfología de la zonamarítima en la provincia de Santa Elena, tratando depredecir si las características propias del lugar son idóneas  para producir electricidad en base a la implementación de energíaundimotriz, como fuente renovable no convencional utilizando las tecnologías actuales para este propósito.

  17. Minería de datos con técnica cluster, caso de estudio: estudiantes de Universidad Estatal Península de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Mariuxi De La Cruz

    2015-10-01

    Full Text Available Este trabajo fue realizado para la Universidad Estatal Península de Santa Elena, muestra el proceso de minería de datos aplicando la técnica cluster o conglomerado, con herramientas de software libre como: PostgreSQL, apropiada para el almacenamiento de los datos y R para el análisis estadístico y la generación de los algoritmos que implica la técnica. El análisis cluster fue implementado en datos sociales, económicos y académicos de los estudiantes inscritos en la Facultad de Sistemas y Telecomunicaciones de esta institución de educación superior. El proceso es detallado en tres secciones, la primera donde se describe los conceptos  asociados a minería de datos, técnica cluster y las herramientas tecnológicas utilizadas para explotación de información. En la segunda sección  se describe el proceso de aplicación la técnica cluster con el método particional y con el método jerárquico. En la sección tres se muestra los conglomerados obtenidos al aplicar la técnica en el grupo de datos. Finalmente se presentan las conclusiones y recomendaciones de este trabajo.

  18. Putting the learner in the spotlight – Future directions for English teachers

    Directory of Open Access Journals (Sweden)

    Anne P A Swan

    2013-10-01

    Full Text Available This paper asserts that English teachers’ understanding of their professionalism enables them to ‘put the learner in the spotlight’ through their highly-developed awareness of local contexts of English use. Changing attitudes to English language teacher identity include a revaluation of the’ native-non-native speaker’ dichotomy which is fast becoming irrelevant as teachers assert new identities based on factors such as professional beliefs about their teaching, understanding their students’ needs and understanding the role of English in their contexts. In a globalising world, these aspects no longer require ‘so-called’ native speaker skills, such as pronunciation and knowledge of ‘English’ culture. In fact, dwelling at length on the issues surrounding native and non-native speaker teacher identity tends to cloud understanding of what qualities English teachers need. Interviews with multilingual teachers of English, working in a variety of countries, have revealed an understanding of the diminishing importance of the ‘native speaker’ and the concomitant growth in the confidence of the multilingual teacher. This confidence has been acquired through depth of linguistic knowledge, through observance of other cultures, and through resistance to the encroachment of English by finding a place for the language which satisfies the needs of multilingual users without requiring subservience. In discovering these strengths of multilingual teachers, I show how stepping outside the boundaries of one’s own limited environment allows English language teachers, wherever they come from, to develop a truly enlightened international professionalism which puts learners firmly in the spotlight.

  19. It counts who counts: an experimental evaluation of the importance of observer effects on spotlight count estimates

    DEFF Research Database (Denmark)

    Sunde, Peter; Jessen, Lonnie

    2013-01-01

    observers with respect to their ability to detect and estimate distance to realistic animal silhouettes at different distances. Detection probabilities were higher for observers experienced in spotlighting mammals than for inexperienced observers, higher for observers with a hunting background compared...... with non-hunters and decreased as function of age but were independent of sex or educational background. If observer-specific detection probabilities were applied to real counting routes, point count estimates from inexperienced observers without a hunting background would only be 43 % (95 % CI, 39...

  20. Las reformas al impuesto al valor agregado y su efecto en la economía del consumidor en la provincia de Santa Elena. Año 2016

    Directory of Open Access Journals (Sweden)

    Nelson Asencio Cristóbal

    2017-05-01

    Full Text Available El objetivo del presente reporte es elaborar un análisis de las reformas tributarias del IVA implementadas en el país en el año 2016 y referir su  impacto en la economía del consumidor en la provincia de Santa Elena. Desde una perspectiva teórica, se define la estructura impositiva del país y su importancia en la generación de ingresos públicos para la consecución objetivos sociales; así como también los fines que conllevan las reformas tributarias tendientes a regular la economía, fomentar el empleo, incentivar la producción, la demanda y el consumo. En la investigación que dio origen a este artículo se aplicaron procedimientos metodológicos  deductivo, cuantitativo, y documental provenientes de fuentes oficiales y  técnicas de investigación que permitieron obtener información relevante para el análisis descriptivo  de las reformas, cuyos resultados reflejan la necesidad de que el gobierno, previa a la adopción de estas medidas,  realice con profundidad un estudio  socio-económico, que permita valorar las incidencias que tendrían en el sector productivo del país y en el consumido específicamente.  En la investigación se describen las últimas reformas tributarias del IVA para luego referir su efecto general en el consumo de bienes y servicios del consumidor peninsular.   Abstract The objective of the present report is to develop an analysis of VAT tax reforms implemented in the country in the year 2016 and see its impact on the economy of the consumer in the province of Santa Elena. From a theoretical perspective, defines the country's tax structure and its importance in the generation of revenue to achieve social objectives; as well as also the purposes involving tax reforms aimed at regulating the economy, promoting employment, encourage the production, demand and consumption. In the research that gave origin to this article is applied procedures methodological deductive, quantitative, and documentary from of

  1. Parque temático turístico cultural como alternativa de diversificación de la oferta turística en la ciudad de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Mercedes Freire Rendón

    2017-05-01

    Full Text Available El turismo de sol y playa es el segmento que genera mayor flujo de turistas y representa un motor importante para el desarrollo de la actividad en muchos países. Sin embargo, el hacinamiento, el deterioro ambiental, los cambios en la demanda y el aumento de la competencia han generado preocupación por el futuro de los destinos consolidados de sol y playa. Dada esta afirmación, y siendo Santa Elena una localidad con estas características, se hace relevante buscar alternativas de diversificación de la oferta turística que permitan dinamizar procesos de desarrollo sostenible del sector. El Objetivo de esta investigación, consiste en determinar el parque temático turístico cultural como alternativa de diversificación de la oferta turística en la ciudad de Santa Elena. La metodología utilizada se basó en un enfoque cualitativo-cualitativo apoyado en la recolección de datos con el diseño de entrevistas en profundidad con actores comunitarios como informantes clave para determinar las categorías a evaluar y establecer elementos esenciales del diagnóstico. Los principales resultados determinaron que en la ciudad de Santa Elena a pesar de la existencia del museo Amantes de Sumpa con enfoque cultural no hay lugar o atracción turística con temática que relacione lo recreativo y cultural, representando costumbres y tradiciones locales para la satisfacción de los visitantes.   Abstract The tourism of sun and beach is the segment that generates greater flow of tourists and represents an important motor for the development of the activity in many countries. However, overcrowding, environmental deterioration, changes in demand and increased competition have generated concern about the future of consolidated sun and beach destinations. Given this assertion, and being Santa Elena a locality with these characteristics, it becomes relevant to look for alternatives of diversification of the tourist supply that allow to dynamize processes of

  2. Modelos explicativos del cambio en la cobertura del suelo en el crecimiento del uso urbano de la provincia de Santa Elena - Ecuador

    Directory of Open Access Journals (Sweden)

    Dany Salazar

    2016-11-01

    Full Text Available En el año 2009, el gobierno vigente del Ecuador plantea a los gobiernos autónomos descentralizados, los requerimientos de una planificación y ordenamiento en sus respectivos territorios, para que su uso sea sostenible. Por ende, la demanda de insumos de información estadística y geográfica ha sido una prioridad dentro de este ámbito gubernamental. Así tenemos que, la presente contribución investigativa propone brindar insumos de información que de soporte a la planificación y ordenamiento territorial de la Provincia de Santa Elena, Área de Planificación Nº 5 - Ecuador. Siendo uno de los insumos prioritarios la identificación de factores explicativos que inciden en el crecimiento urbano, tales como el biofísico, socioeconómico y de accesibilidad. Para ello se ha seleccionado como unidad de mínima integración de información al pixel y como técnica estadística Regresión Logística. Entre los principales resultados tenemos la implementación de la estandarización, bajo el criterio lineal decreciente para la homogenización de las variables de accesibilidad potenciando al modelo seleccionado y la utilización de herramientas potentes de las Tecnologías de la Información Geográfica, que ha permitido la implementación de modelos con volumen significativo de datos.

  3. Proyecto de factibilidad para la creación de una institución financiera de crédito prendarío, en la libertad-provincia de Santa Elena

    OpenAIRE

    Abril Briones, Ruben Dario; Estrada Guzman, Jairo Alfredo; Romero Montoya, Maria Elena

    2009-01-01

    El presente documento pretende justificar, económica y financieramente, la creación de una Institución Financiera de Crédito Prendario en La Libertad-Provincia de Santa Elena. Este proyecto muestra una alternativa de conceder financiamiento a través de créditos prendarios, además de desarrollar un mecanismo para facilitar los créditos, ofrecerá la debida protección de preservar la autenticidad y seguridad de los activos que garantizan los créditos prendarios, e incentivar una cultura de aper...

  4. Elena de Miguel Aparicio El aspect en la sintaxis del Español perfectividad e impersonalidad Ediciones de Ia Universidad Autónoma de Madrid, 1992, p. 264.

    Directory of Open Access Journals (Sweden)

    Jasmina Markič

    1993-12-01

    Full Text Available No son muchas las obras destinadas en su totalidad al estudio del aspecto en español por lo que la publicación dellibro de Elena de Miguel Aparicio llama tanto más la atención especialmente en nuestro · ambiente lingüistico eslavo di:mde el aspecto, como es sabido, tiene una importancia especial. La autora se dedica al estudio del aspecto como categoría independiente del tiempo desde una perspectiva oracional utilizando el modelo actual de la gramática generativa denominado Rección y Ligamiento.

  5. Incidencia del estilo de vida en el rendimiento académico de los estudiantes, mediante un análisis interno en la Universidad Estatal Península de Santa Elena UPSE, de la provincia de Santa Elena año 2014.

    Directory of Open Access Journals (Sweden)

    Karina Bricio

    2015-10-01

    The present investigation has as objective to evaluate the incidence of the lifestyle in the academic yield of the students of the University State Peninsula of Santa Elena UPSE, the project is framed in knowing the lifestyles of the students that activities make in their free times, and in many of the cases because its academic yield diminishes, by means of technical of observation and interviews it was determined that the students spend stressed, they don't take a healthy lifestyle, they carry out little sport, they pass navigating in the social nets, they like to see the television a lot, and they dedicate few hours to study. It is for it the importance and the development of this project to give to know to the authorities that make their students outside of the university and in that use their free times. The methodology that you applies was of two types, quantitative and qualitative investigation, between the results of the analysis of the questionnaires and the focus groups, was determined that the students dedicate two hours to study, they don't sometimes attend classes for illness, laziness, or they are sleeping, they like to play soccer, to leave to parties, they consume alcoholic drinks, they consume tobacco, they navigate two hours and more in the social nets, they travel little for lack of resources, and in most of the cases they don't have breakfast, they read little, which affects its academic yield in great measure.

  6. Space-Variant Post-Filtering for Wavefront Curvature Correction in Polar-Formatted Spotlight-Mode SAR Imagery

    Energy Technology Data Exchange (ETDEWEB)

    DOREN,NEALL E.

    1999-10-01

    Wavefront curvature defocus effects occur in spotlight-mode SAR imagery when reconstructed via the well-known polar-formatting algorithm (PFA) under certain imaging scenarios. These include imaging at close range, using a very low radar center frequency, utilizing high resolution, and/or imaging very large scenes. Wavefront curvature effects arise from the unrealistic assumption of strictly planar wavefronts illuminating the imaged scene. This dissertation presents a method for the correction of wavefront curvature defocus effects under these scenarios, concentrating on the generalized: squint-mode imaging scenario and its computational aspects. This correction is accomplished through an efficient one-dimensional, image domain filter applied as a post-processing step to PF.4. This post-filter, referred to as SVPF, is precalculated from a theoretical derivation of the wavefront curvature effect and varies as a function of scene location. Prior to SVPF, severe restrictions were placed on the imaged scene size in order to avoid defocus effects under these scenarios when using PFA. The SVPF algorithm eliminates the need for scene size restrictions when wavefront curvature effects are present, correcting for wavefront curvature in broadside as well as squinted collection modes while imposing little additional computational penalty for squinted images. This dissertation covers the theoretical development, implementation and analysis of the generalized, squint-mode SVPF algorithm (of which broadside-mode is a special case) and provides examples of its capabilities and limitations as well as offering guidelines for maximizing its computational efficiency. Tradeoffs between the PFA/SVPF combination and other spotlight-mode SAR image formation techniques are discussed with regard to computational burden, image quality, and imaging geometry constraints. It is demonstrated that other methods fail to exhibit a clear computational advantage over polar-formatting in conjunction

  7. Fortalecimiento del sector de la soldadura en la Provincia de Santa Elena a través de actividades del Centro de Capacitación de Soldadura LINDE-UPSE

    Directory of Open Access Journals (Sweden)

    Jorge Lucin

    2015-10-01

    Abstract The generation of grands projects that the country has, in its execution bears the important contribution of technical work such as welding. The University Santa Elena Peninsula, UPSE and multinational LINDE, ex AGA S.A.,  in order to strengthen the area of welding work in the province of Santa Elena, have signed a cooperation agreement with a duration of 5 years. For this purpose, is installed, an Training Center first order with equipment, machinery, tooling and supplies needed to offer quality work. Physical resources are given to UPSE, while knowledge and technique gives the multinational facilitator through highly qualified instructor.  The courses   to offering are approbation. The work is organized upon circulation, registration, training, evaluation, approval and final reports for each course, which is based on the statistics and media documents. Thus, over the first 3 years of work, has trained 229 people, with a total of 240 hours in 12 basic curs for welders support. Representative institutions in these works have been favored by updating technical knowledge and taught at the Center. The agreement remaining 1.5 years to finish but given its fruitful work, surely renew contributions towards this important technical work such as welding.

  8. Compositional diversity in peridotites as result of a multi-process history: The Pacific-derived Santa Elena ophiolite, northwest Costa Rica

    Science.gov (United States)

    Escuder-Viruete, Javier; Baumgartner, Peter O.; Castillo-Carrión, Mercedes

    2015-08-01

    The Santa Elena ophiolite (SEO) is an ultramafic nappe of more than 270 km2 overlying a tectonic serpentinite-matrix mélange in northwest Costa Rica. It is mainly composed of Cpx-rich and Cpx-poor harzburgites (~ 2.5 km-thick), with minor lherzolite, dunite and chromitite, as well as intrusive mafic sills and subvertical dikes, which coalesce into an upper Isla Negritos gabbroic sill complex. Minerals and whole-rock features of the Cpx-rich and Cpx-poor harzburgites share features of the abyssal and supra-subduction zone (SSZ) peridotites, respectively. To explain these characteristics two-stages of melting and refertilization processes are required. By means of trace element modeling, the composition of Cpx-rich harzburgites may be reproduced by up to ~ 5-10% melting of a primitive mantle source, and the composition of Cpx-poor harzburgites and dunites by ~ 15-18% melting of an already depleted mantle. Therefore, the Cpx-rich harzburgites can be interpreted as product of first-stage melting and low-degrees of melt-rock interaction in a mid-ocean ridge environment, and the Cpx-poor harzburgites and dunites as the product of second-stage melting and refertilization in a SSZ setting. The mafic sills and the Isla Negrito gabbros are genetically related and can be explained as crystallization from the liquids that were extracted from the lower SSZ mantle levels and emplaced at shallow conditions. The Murciélagos Island basalts are not directly related to the ultramafic and mafic rocks of the SEO. Their E-MORB-like composition is similar to most of the CLIP mafic lavas and suggests a common Caribbean plume-related source. The SEO represents a fragment of Pacific-derived, SSZ oceanic lithosphere emplaced onto the southern North America margin during the late Cretaceous. Because of the predominance of rollback-induced extension during its history, only a limited amount of crustal rocks were formed and preserved in the SEO.

  9. INCIDENCIA DE LOS SISTEMAS DE CONTROL CONTABLE EN LA GESTION ADMINISTRATIVA DE LAS EMPRESAS PRIVADAS EN LA PROVINCIA DE SANTA ELENA AÑO 2014

    Directory of Open Access Journals (Sweden)

    Karina Bricio

    2016-04-01

    Full Text Available La presente investigaciones tiene como objetivo evaluar la incidencia de los  sistemas de control contable en la gestion administrativa de las emoresas privadas en la provincia de Santa Elena, el proyecto está enmarcado dentro del área de gestion administrativa, comunicación organizacional, control contable, informes financieros, control de registros contables, entre otros, se han venido desarrollando desde hace años los procesos administrativos de una manera manual y se han implementadi sistemas de control financieras, sin embargo en las empresas ecuatorianas la contabilidad se ha convertido en  una tecnica que se ocupa de registrar, clasificar y resumir las operaciones mercantiles de un negocio con el fin de interpretar sus resultados. Por consiguiente los gerentes o directores através de la contabilidad podrán orientarse sobre el curso que siguen sus negocios mediante sistemas o software contable. Los resultados podrán orientarse sobre el curso que siguen sus negocios y conocer las estabilidad y solvencia de la compañia, la corriente de cobros y pagos, las  tendencias de las ventas, costos y gastos  generales, con la técnica de observacion y mediantes entrevistas se determinó que en muchas empresas de provincia no hay sistemas de controles contables, el cual no manejan de forma eficiente los procesos contables ni administrativos, tambien se observó que se utilizó para el analisis correspondiente fue de tipo cuantitativo el cual se realizó encuestas a las personas que trabajan en las areas  administrativas de las empresas de la provincia, entre los resultados encontrados se mecniona lo siguiente: los  sistemas de control contable que utilizan actualmente las empresas son, el sistema Mónica, sistema Sagitario, el sistema Siscom,mennioaron tambien que la falta de sistemas de control contable retrasa la gestion administrativa de le empresa, necesitan cursos de capacitaciones y actualizaciones en temas de tributacion, sistemas

  10. Legend tummast abilisest / Elena Lass

    Index Scriptorium Estoniae

    Lass, Elena

    2003-01-01

    PÖFFi Suvekino raames näidati Tallinna Linnaarhiivi siseõues saksa tummfilmi programmi "Öised varjud". Paul Wegeneri ja Carl Boese 1920. a. valminud filmile "Golem, kuidas ta maailma tuli" tegid saatemuusikat Marianne Kõrver, Rainer Jancis ja Raoul Kurvitz

  11. Elaboración de hormigones que minimicen el impacto al ambiente, empleando neumáticos usados de vehículos livianos y pesados, en la provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Armando Saltos

    2016-04-01

    En su segunda etapa se realizará el diseño de hormigón incluyendo las partículas de neumáticos triturados, en el que se dará a conocer cuál es el porcentaje óptimo que se incluirá este material con respecto al hormigón. Por lo tanto con la ejecución de este proyecto se reduciría sustancialmente la contaminación que produce este tipo de desechos, además de proporcionar un uso adecuado en términos de construcción en la provincia de Santa Elena.

  12. Breve síntesis histórica y reflexiones acerca de la continuidad étnica, sentido de etnicidad e identidad cultural en la región de Santa Elena, Ecuador

    Directory of Open Access Journals (Sweden)

    Erick López Reyes

    2016-12-01

    Abstract   This paper presents a brief summary of the pre-Hispanic and colonial history of the Santa Elena region, from the first arrival of human groups in the area until the early days of the new Republic of Ecuador. By giving narrative body to a series of data dispersed product of archaeological research, and historical documentaries, made in the region since early last century actually. Based on them then arises a necessary and relevant reflection on issues such as ethnic continuity, ethnicities, culture and identity of the current human groups, descendants of the previous, now inhabit, also raising the importance this has in ongoing processes, and those potential to undertake, for the advancement and local socio-economic development through New tourism or innovation tourism.

  13. La construcción de la imagen heroica a través del discurso periodístico. El caso de la activista peruana María Elena Moyano.

    Directory of Open Access Journals (Sweden)

    Gabriela McEvoy.

    2008-01-01

    Full Text Available This work tries to demonstrate that the social construction of the national hero/heroine as a symbol of courage and resistance generally arises within a period of social, political, and economic crisis. The national hero is a construction that is created in a moment characterized by the loss of public trust and the failure of government leaders to act. The creation of the heroic image functions as a sociopolitical tool. The article suggests that there is a close relationship between the history and the construction of heroic fgures. Using the death of Peruvian activist María Elena Moyano as a concrete example, it demonstrates that journalistic discourse has the ability to create an heroic image around a person who has been given the traditional role that the hero has played in society since Antiquity.

  14. World nuclear power once again in the spotlight. Comments on the 13th Pacfic Basin Nuclear Conference

    International Nuclear Information System (INIS)

    Zang Mingchang; Ruan Keqiang

    2004-01-01

    This paper comments on The 13th Pacific Basin Nuclear Conference held in Shenzhen, China, on October 21/25, 2002 and summarizes some key papers presented in the Conference and viewpoints from their following discussions, which indicates that nuclear power in the world is once again in the spotlight. The Conference shows that in the coming 50 years the roadmap to develop nuclear energy would be divided into two stages: Near-Term Deployment by 2010-2015, some advanced designs were developed for Utilities; Generation IV Program, its overall goal is to identify and develop next-generation nuclear power systems that could be deployed over the next 30 years to help meet the world's energy needs throughout the 21st century. Some visions is the future, such as co-generation of electricity and space heating or desalination, and combination of Generation IV and so-called Hydrogen Economy-the use of hydrogen in vehicle transport to replace petroleum, were presented. As a primary energy source nuclear power is particularly well suited to hydrogen production, offering the almost unique position of large-scale hydrogen production with near-zero emissions. (authors)

  15. Lack of interest in physical activity - individual and environmental attributes in adults across Europe: The SPOTLIGHT project.

    Science.gov (United States)

    Carraça, Eliana V; Mackenbach, Joreintje D; Lakerveld, Jeroen; Rutter, Harry; Oppert, Jean-Michel; De Bourdeaudhuij, Ilse; Compernolle, Sofie; Roda, Célina; Bardos, Helga; Teixeira, Pedro J

    2018-06-01

    A considerable proportion of European adults report little or no interest in physical activity. Identifying individual-level and environmental-level characteristics of these individuals can help designing effective interventions and policies to promote physical activity. This cross-sectional study additionally explored associations between level of interest and physical activity, after controlling for other individual and environmental variables. Measures of objective and perceived features of the physical environment of residence, self-reported physical activity and other lifestyle behaviors, barriers towards physical activity, general health, and demographics were obtained from 5205 European adults participating in the 2014 online SPOTLIGHT survey. t-Tests, chi-square tests, and generalized estimating equations with negative binomial log-link function were conducted. Adults not interested in physical activity reported a higher BMI and a lower self-rated health, were less educated, and to a smaller extent female and less frequently employed. They were more prone to have less healthy eating habits, and to perceive more barriers towards physical activity. Only minor differences were observed in environmental attributes: the non-interested were slightly more likely to live in neighborhoods objectively characterized as less aesthetic and containing more destinations, and perceived as less functional, safe, and aesthetic. Even after controlling for other individual and environmental factors, interest in physical activity remained a significant correlate of physical activity, supporting the importance of this association. This study is among the first to describe characteristics of individuals with reduced interest in physical activity, suggesting that (lack of) interest is a robust correlate of physical activity in several personal and environmental conditions. Copyright © 2018 Elsevier Inc. All rights reserved.

  16. Efecto de la vinculación con la colectividad en el beneficio económico de las asoociaciones de producción. Caso de estudio: Paja Toquilla en la Comuna Barcelona, Parroquia Manglaralto. Provincia de Santa Elena, año 2015

    Directory of Open Access Journals (Sweden)

    Juan C Carriel

    2015-12-01

    Abstract The State University of Santa Elena Península and Accounting and Auditing Career; in the framework of a process of linking with the community, allows the interaction of the institution with the society, through the design and implementation of projects that contribute to the development, constituting itself as a benefit in the advancement of knowledge, training of human talent, the exchange of ideas and the solution of specific problems. In Ecuador, artisans occupy an important place, as regards to economic development is further directed to have laws backup as the law of defense of the artisan, the law to promote artisanal production code, whose common goal It is to enable economic growth of artisans and contribute to meeting the objective 1, 3, 10 of the National Plan for Good Living. So the implementation of links with the community was framed for artisans who are engaged in the production of straw shawl in the commune Barcelona, Manglaralto parish, canton Santa Elena, Province of Santa Elena, in order to contribute to the socioeconomic improvement associations union through the exchange of knowledge and generate from its production processes; accounting, where the level of profitability of the activity is known, and also have a reliable database for timely decision-making; allowing the sustainable development of the producer.

  17. Evolución del sector servicios de alojamiento y restauración y su contribución al desarrollo económico de Ayangue, Provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Sabina Villón Perero

    2017-05-01

    Full Text Available Las actividades turísticas, en especial los servicios de alojamiento y restauración han mantenido una importante participación en la economía del Ecuador durante los últimos años, a partir de esta premisa se consideró relevante realizar el presente estudio que consiste en el análisis de la evolución del sector en mención y su contribución al desarrollo económico de la comuna Ayangue ubicada en la provincia de Santa Elena. Para ejecutar la investigación de campo se tomó una muestra de establecimientos dedicados a las mencionadas actividades, así como también se realizó un estudio socioeconómico mediante la aplicación de  encuestas y entrevistas las mismas que permitieron  obtener información cualitativa y cuantitativa, cuyos resultados evidenciaron cómo ha  evolucionado este sector y el impacto que ha generado en el desarrollo de la comunidad a través del tiempo, los mismos que reflejaron el incentivo de emprendimientos, la  generación de plazas de trabajo y el mejoramiento del nivel económico y social de los comuneros.     Abstract Tourist activities, specially Accommodation and provision of food and beverages services, have had an important participation in the economy of Ecuador in the last years, based on this premise it was considered relevant to carry out the present study, which is an analysis of the sector in question and their contribution to economic development of the Ayangue Commune, in Province of Santa Elena. For perform field investigations, it took a sample of establishments and was performed a socio-economic study, using surveys and interviews, which they allowed to obtain qualitative and quantitative information, whose results showed the evolution of this sector and the impact generated in the community development through time, resulting incentive enterprises, generating jobs and improving the economic and social level of the community members.

  18. [The intervention of Dr Francisco Díaz in the inquisitorial process against Elena/o de Cespedes, a transsexual surgeon found guilty by the Inquistion in Toledo in 1587].

    Science.gov (United States)

    Maganto Pavón, Emilio

    2007-10-01

    To make known, comprehensively, an almost unknown episode in the life of Dr. Francisco Diaz (1527-1590), surgeon of the king Philip II, and author of the first urology treaty in the history of medicine. To our knowledge, to date there were few references about the participation that, as an expert, Francisco Diaz had to have in the inquisitorial process against Elena de Cespedes, a presumed hermaphrodite accused by the Inquisition because being a woman married another one pretending to be a man. The trial was carried out in Toledo in 1587 and had great impact in that time, because the accused, dressing with male clothes and usurping the prerogatives of a man, had gotten by fraud titles and favours which were forbidden for women, the title of surgeon among them. Except for the reference by Folch Jou and Burshatin, both short and incomplete, no other author or biographer of the famous surgeon had cited this episode of his life, which to our judgment could mean a great damage to his reputation. We reviewed the works by the two aforementioned authors, all the works and biographies about Dr. Francisco Diaz that we could found, and microfilmed and transcript the whole bundle 234, expedient 24, from the section Inquisition at the National Historical Archive in Madrid, corresponding to Elena de Cespedes (alias Eleno) (> 500 pages) to obtain the greatest amount of data about the accused and the performance of Dr. Francisco Diaz. Francisco Diaz was requested, as an expert, by the Vicar of Madrid to perform the examination of the genitourinary organs to give or not marriage license to that woman saying she was a man. In his report in the year 1586, surprisingly the urologist declared that the petitioner was a man. As it would be demonstrated during the trial, the accused, who alleged being hermaphrodite in her defense, had been able to deceive the expert with her tricks altering her genital morphology. Thanks to her surgical knowledge she had mutilated herself surgically

  19. Interrelación de la productividad en el sector artesanal y la vinculación con la colectividad: red de artesanos de la parroquia Atahualpa, provincia de Santa Elena, año 2015

    Directory of Open Access Journals (Sweden)

    Germán Arriaga Baidal

    2016-12-01

      One of the areas of the work of the universities is their relationship with the community, which must generate a productivity interrelationship in both parts. Thus, she connects with teaching and invigorates it. The Santa Elena Peninsula State University and the Department of Linkage through the Accounting and Auditing Career develop this process, with the design and execution of projects that contribute to the development and generate alternative solutions to the problems of the communities. It is currently debated, if the link is understood as the moment in which the university relates to external social actors, without considering the participation of students and teachers in that process, and its effects, both in the community and in University teaching. In the pursuit of productivity, each linking teacher prepares and executes a series of actions, in order to have a positive impact on the student's and the trainee's training process, and their participation in linking projects, a valuable moment that is also considered as an indicator Of productivity - quality, in the field of teaching.

  20. Elaboración de hormigones que minimicen el impacto al ambiente, empleando neumáticos usados de vehículos livianos y pesados, en la provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Armando Saltos

    2015-10-01

    Waste from rubbers tires are considered to be an environmental and sanitary risk worldwide. As an example in Ecuador, every year nearly 2.4 million rubber tires of various types are discarded as trash, which is equivalent to 55000 tons, according to the Proactive Corporation for Investment Promotion (INVEC. A small porcentage of the waste, are reused to be re-rubberized. But the majority is incinerate or deposited in dumping grounds open to the environment, which is a huge risk to the environment and the health of individuals. The project seeks to create a design of concrete including particles of rubber from discarded tires. The tires will undergo a rigorous selection process, a controlled threading process, and a fabrication according to the specifications of the international standards of concrete of the American Concrete Institute (ACI and the Construction Ecuatorian Standards (NEC, and based on these specifications, the goal is to obtain an acceptable concrete apt to be used in low traffic streets, sidewalks, pedestrian zones, and other concrete structures, minimizing the environmental impact to the misuse of tires in the province of Santa Elena.

  1. Incidencia de la gestión de marketing y procedimientos de injerencia contable en las empresas privadas de la Provincia de Santa Elena, año 2014-2015

    Directory of Open Access Journals (Sweden)

    Libi Caamaño

    2015-12-01

    Abstract Accounting control systems allow the company to know about the economic situation and make decisions; secondly marketing management facilitates compliance with business objectives, to capture the attention of the target market, encouraging customers to purchase action, and current customer loyalty, these two components enable companies to take advantage of any kind environmental opportunities to know the current situation, so the negative impact is minimized. This study aims to assess the impact of accounting control systems and marketing in the administration of private enterprises in the province of Santa Elena, the process of gathering information was aimed at obtaining information from the company managers, financial personnel and public relations in the absence of marketing department in the majority of companies. It was evident that no innovative strategic actions in companies, that will generate knowledge effectively brand in the target market, however, the accounting systems used are appropriate, whether made mostly traditional way, not technological tools are used. The importance of implementing accounting control systems that improve the administrative management of private enterprise in the province, as well as marketing efforts to improve compliance with business objectives entities was determined.

  2. INCIDENCIA DE UN PLAN DE DESARROLLO TURÍSTICO EN LA SOSTENIBILIDAD Y COMPETITIVIDAD DE LA COMUNA EL REAL, PARROQUIA CHANDUY, CANTÓN SANTA ELENA, PROVINCIA DE SANTA ELENA” AÑO 2015

    Directory of Open Access Journals (Sweden)

    Mercedes Freire

    2016-12-01

    Full Text Available La presente investigación tiene como objetivo determinar la incidencia de un plan de desarrollo turístico en la sostenibilidad y competitividad de la Comuna El Real, de la Provincia de Santa Elena, en el cual se debe aprovechar el recurso natural y cultural que tiene la comuna, donde se propicie la generación de una dinámica auténtica para la captación del turismo rural con la lógica y generación de un desarrollo desde adentro, contribuyendo de este modo al buen vivir de la comuna. Entre los problemas que se evidenciaron se encuentra la sostenibilidad, no cuenta con un desarrollo ambiental, económico, y social, proyectos de emprendimiento, se plantea estrategias sostenibles y competitivas desde la perspectiva del turismo rural. Para la elaboración de este trabajo se utilizó la metodología basada en investigación cuantitativa y cualitativa. Se describió las características generales de la problemática existente, permitiendo elaborar una diagnostico situacional de tipo integral, con la implementación de estrategias como son, los convenios con las instituciones del estado, cursos de capacitaciones a los comuneros para que puedan realizar una eficiente administración comunal, buen trabajo en equipo, ejecución de programas y proyectos, participación oportuna de los habitantes para el logro de un crecimiento permanente para la comuna, sus organizaciones y asociaciones ubicadas dentro de su territorio.  Palabras clave: recursos turísticos, recursos culturales, desarrollo sostenible, estrategias competitivas Abstract This research aims to determine the incidence of a plan of tourist in the sustainable environmental, economic and social development, through an internal of the Commune diagnosis the Real, of the Province of Santa Elena, which should benefit from the natural and cultural resource that has the commune, where is conducive to the generation of a real dynamic for the acquisition of rural tourism with the logical

  3. Estudio sobre las Competencias Demandadas por las Empresas, para la Inserción Laboral de los Profesionales en la Provincia de Santa Elena año 2013.

    Directory of Open Access Journals (Sweden)

    Jairo Cedeño

    2015-10-01

    Full Text Available La presente investigación tiene como objetivo determinar las competencias demandadas por las empresas tanto públicas y privadas de la provincia y analiza la inserción laboral de los profesionales. Hoy en día las empresas crecen, se expanden y esa es la oportunidad para que las universidades oferten estudiantes con habilidades, destrezas y conocimientos de acuerdo a lo que las empresas demandan. Por ello la importancia de este estudio el cual determinó las competencias que demandan las empresas para poder insertar a nuestros profesionales en las diversas áreas laborales, para que se puedan explotar esas capacidades adquiridas en la universidad. Se realizó un estudio cuantitativo el cual determinó que en las empresas de la provincia de Santa Elena se encuentran laborando jóvenes entre las edades de 25 a 35 años. En su proceso de reclutamiento de personal están considerando como primera instancia, experiencia laboral, seguido formación profesional, título académico, cursos de actualización entre otros. Entre las principales actividades que realizan los profesionales corresponde a las áreas contables, gestión del talento humano, evaluación y formulación de proyectos, presupuesto y compras públicas. Se determinó además entre las principales destrezas que deben de tenerlos profesionales al momento de incorporar en el ámbito laboral es; trabajo en equipo, liderazgo, ética profesional y conocimiento en el idioma Ingles. La provincia se destaca por su turismo, relaciones humanas, y conocimientos administrativos.

  4. La conservación de las aves más allá de las áreas naturales protegidas: el caso de la avifauna del Rancho Santa Elena, Hidalgo

    Directory of Open Access Journals (Sweden)

    Miguel Angel Martínez-Morales

    2013-07-01

    Full Text Available La conservación de la biodiversidad dentro de las áreas naturales protegidas (ANP no siempre es eficiente y suficiente, no obstante sus logros como uno de los instrumentos más consolidados de conservación. En este trabajo discutimos la pertinencia de considerar la información generada más allá de un ANP para elaborar e implementar su programa de manejo con una perspectiva de conservación regional; esto, a través de un ejercicio de comparación de la información generada sobre la avifauna dentro y fuera del ANP. En este marco, presentamos los avances en el conocimiento de la diversidad de aves en el bosque templado del Rancho Santa Elena (RSE, un conjunto predial ubicado en la Sierra de las Navajas, próximo al Parque Nacional El Chico (PNEC, en el estado de Hidalgo, México. Desde 2005 a la fecha hemos registrado 90 especies de aves a partir de muestreos con redes de niebla, del recorrido no sistemático de senderos y de observaciones incidentales. Estimamos que esta riqueza de especies representa aproximadamente el 70% de la riqueza esperada en el sitio. En contraste, en el PNEC se han registrado 74 especies desde 1974, de las cuales al menos ocho representan registros incorrectos o probablemente incorrectos. Asimismo, en el RSE hemos registrado una mayor diversidad de gremios trófico-conductuales y de especies endémicas a México que las registradas en el PNEC. Los inventarios y la generación de conocimiento más allá de las ANP pueden ser insumos importantes en la definición e implementación de sus estrategias de manejo, las cuales deben tener una perspectiva de conservación regional.

  5. Evaluación de ideas irracionales en los postulantes de diversas carreras que oferta la Universidad Estatal Península de Santa Elena en el segundo semestre del periodo 2013 – 2014

    Directory of Open Access Journals (Sweden)

    Rocío Ponce

    2015-10-01

    Abstract This research conducted at the Santa Elena Peninsula University evaluates the belief systems that have been increasing in the social and technological careers in the sense of values is important and essential, applicants offered eight careers such as Accountants, nursing, Tourism, IT, civil engineering, petroleum engineering, Administration and Marine Biology held belief systems can affect school performance and expectations with entering the higher education system. Ten areas of the TCI Test Irrational ideas are revised and abbreviated version Need for acceptance test, the presence of self expectations, guilt, frustration intolerance, levels of worry and anxiety, emotional irresponsibility, problem avoidance, dependence are evaluated , helplessness and perfectionism. This is a first test survey on belief system based on other higher studies in similar populations and the results show similar levels of belief systems among students majoring in question and then a comparative study with a population of the School of Psychology that is graduating. Statistical analysis of the data would show the areas where from the Student Welfare Department should work to change certain ways of thinking that do not allow the normal development of academic activities. An analysis of the percentages for items of irrationality in the areas further ago. In order to meet our student population and to anticipate better performance in their step and their permanence in the institution of higher education. Were evaluated without regard to the whole population has been called because that way you can check more accurately the data in question. Is proposed on the basis of these data to initiate a program of psychological intervention to strengthen comprehensively changes belief systems and values that will promote technological change in line with the social area and rescue principles and ways of thinking from the region and to be based on good living. The projection having on

  6. Spotlight on the media

    CERN Multimedia

    2007-01-01

    Do you want to know more about how the media works, how to deal with journalists? How to maximise opportunity and minimise threat? Then please join us on 22 November. This session will cover how to work effectively with the media, including print, radio and TV. You’ll get an insight into how journalists and news rooms operate. You’ll learn to recognise both soft balls and traps - and develop the techniques for dealing with them. The challenges of explaining CERN to any media outlet will be dealt with too. This interactive presentation, given by Jessica Pryce-Jones, Managing Director of the consultancy firm iOpener Ltd, and Nisha Pillai, news anchor for BBC World, will be illustrated with various case studies. How to deal with the media: maximising opportunity and minimising threat Thursday 22 November, from 4.30 pm, Main Auditorium, Bldg. 500 Coffee break before the event at 4.00 pm

  7. Spotlight. China. Part II.

    Science.gov (United States)

    Brophy, G

    1989-04-01

    China's 1-child policy was promulgated in 1979. Those couples who pledged to have 1 child could receive monetary bonuses, preferential treatment for housing, plot and grain allocation, health care, education, and job opportunities. The precise value of the package varied substantially. By 1981 47.3% of births were 1st births; in 1970, 21% were 1st births. Couples' renouncement of the 1-child pledge varied by province from less than 5% to 34%; 12.5% of holders who had had a girl renounced their pledge, compared to 6.7% who had had a boy. Despite a 1950 law designed to improve women's status,inequalities persist, and privileges accorded to 1-child certificate children, who are more likely to be male, may inadvertently perpetuate inequality. A provision of the 1980 Marriage Law making daughters as well as sons responsible for old age support and the development of handicraft and sideline occupations in rural areas may increase perception of daughters as economic assets. Although fertility may have declined, it remains a fundamentally important Chinese institution. Fertility is concentrated among women in the 20s, with urban fertility more compressed into shorter age interval than is the case in rural areas. There were campaigns to encourage abortion, sterilization, and IUD insertion in late 1982 and early 1983. The number of sterilizations/year increased from 5.1 million in 1982 to 20.8 million in 1983. As of 1983, the mix of contraceptive methods ranged as follows: 50% sterilization, 41% IUD, and 9% others. From 1984-85, the proportion of 1st births declined from 56% to 50%, with 2nd births absorbing the increase. In 1986-88, following a period of relative leniency, family planning goal became somewhat more stringent, and to responsibility systems, such as goal management in which couples together with multiple administrative levels must guarantee compliance with program objectives, are being emphasized. At the same time, several pilot programs allowing a 2nd child after substantial delay are being tested.

  8. Physics in the Spotlight

    Science.gov (United States)

    2000-10-01

    CERN, ESA and ESO Put Physics On Stage [1] Summary Can you imagine how much physics is in a simple match of ping-pong, in throwing a boomerang, or in a musical concert? Physics is all around us and governs our lives. The World-Wide Web and mobile communication are only two examples of technologies that have rapidly found their way from science into the everyday life. [Go to Physics On Stage Website at CERN] But who is going to maintain these technologies and develop new ones in the future? Probably not young Europeans, as recent surveys show a frightening decline of interest in physics and technology among Europe's citizens, especially schoolchildren. Fewer and fewer young people enrol in physics courses at university. The project "Physics on Stage" tackles this problem head on. An international festival of 400 physics educators from 22 European countries [2] gather at CERN in Geneva from 6 to 10 November to show how fascinating and entertaining physics can be . In a week-long event innovative methods of teaching physics and demonstrations of the fun that lies in physics are presented in a fair, in 10 spectacular performances, and presentations. Workshops on 14 key themes will give the delegates - teachers, professors, artists and other physics educators - the chance to discuss and come up with solutions for the worrying situation of disenchantment with Science in Europe. The European Science and Technology Week 2000 "Physics on Stage" is a joint project organised by the European Organisation for Nuclear Research (CERN) , the European Space Agency (ESA) and the European Southern Observatory (ESO) , Europe's leading physics research organisations. This is the first time that these three organisations have worked together in such close collaboration to catalyse a change in attitude towards science and technology education. Physics on Stage is funded in part by the European Commission and happens as an event in the European Science and Technology Week 2000, an initiative of the EC to raise public awareness of science and technology. Other partners are the European Physical Society (EPS) and the European Association for Astronomy Education (EAAE). European Commissioner Busquin to Visit Physics On Stage On Thursday, November 9, Philippe Busquin , Commissioner for Research, European Commission, Prof. Luciano Maiani , Director-General of CERN, Antonio Rodota , Director-General of ESA, Dr. Catherine Cesarsky , Director-General of ESO, and Dr. Achilleas Mitsos , Director-General of the Research DG in the European Commission, will participate in the activities of the Physics on Stage Festival. On this occasion, Commissioner Busquin will address conference delegates and the Media on the importance of Science and of innovative science and technology education. The Festival Each of the more than 400 delegates of the festival has been selected during the course of the year by committees in each of the 22 countries for outstanding projects promoting science. For example, a group of Irish physics teachers and their students will give a concert on instruments made exclusively of plumbing material, explaining the physics of sound at the same time. A professional theatre company from Switzerland stages a play on antimatter. Or two young Germans invite spectators to their interactive physics show where they juggle, eat fire and perform stunning physics experiments on stage. The colourful centrepiece of this week is the Physics Fair. Every country has its own stands where delegates show their projects, programmes or experiments and gain inspiration from the exhibits from other countries. Physics on Stage is a unique event. Nothing like it has ever happened in terms of international exchange, international collaboration and state of the art science and technology education methods. The Nobel prizewinners of 2030 are at school today. What ideas can Europe's teachers put forward to boost their interest in science? An invitation to the media We invite journalists to take part in this both politically and visually interesting event. We expect many useful results from this exchange of experience, there will a large choice of potential interview partners and of course uncountable images and impressions. Please fill in the form below and fax it back to CERN under +41 22 7850247. Go to the Webpage http://www.cern.ch/pos to find out all about Physics on Stage Festival at CERN. The main "Physics on Stage" web address is: http://www.estec.esa.nl/outreach/pos There is also a Physics On Stage webpage at ESO Notes [1] This is a joint Press Release by the European Organization for Nuclear Research (CERN) , the European Space Agency (ESA) and the European Southern Observatory (ESO). [2] The 22 countries are the member countries of at least one of the participating organisations or the European Union: Austria, Belgium, Bulgaria, the Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Luxembourg, the Netherlands, Norway, Poland, Portugal, the Slovak Republic, Spain, Sweden, Switzerland, United Kingdom.

  9. Spotlight: Bosnia and Herzegovina.

    Science.gov (United States)

    1998-05-01

    This article discusses the demographic outcomes of the end of the civil war in Bosnia and Herzegovina. The war ended with the creation of the Bosnian Serb Republic and the Muslim-Croat Federation. In mid-1998, the population was 3.9 million. The population is smaller than it was before 1991, when Slovenia and Croatia separated from Yugoslavia. Many highly educated people left. Unemployment is an estimated 65-75%. Almost 500,000 soldiers must adjust to being civilians. In 1992, Muslims were 38% of total population, and Croats were 22% of total population. Muslims and Croats are now minorities in the Muslim-Croat Federation. The Serbs, who were 40% of the total population, led a civil war that was motivated by the desire for a Serb Republic. The Serbian "ethnic cleansing" created many thousands of refugees. Since the late 1995 Dayton Accord, about 400,000 refugees and displaced persons have returned to their prewar homes. Muslim-Croat Federation areas have received many refugees and have agreed to participate in the UN High Commissioner for Refugees' "open cities" project. About 1.5 million people are still scattered across Bosnia, Croatia, Yugoslavia, and Western Europe. Refugees are guaranteed under the Dayton Accord the right to return to their homes. However, returning means facing the dangers of land mines and other explosives in rural areas and being stoned along major roadways. Travelers rely on a few selected roads. Buses are considered a safe mode of transportation. The Serb Republic still defies the Dayton Accord, opposes the return of minorities, and enforces ethnic separation.

  10. Spotlight: French Polynesia.

    Science.gov (United States)

    May, J F

    1988-01-01

    French Polynesia is a group of 4 archipelagos in the South Pacific with an estimated 1987 population of 176,600. Its people are mainly Tahitians, Polynesians, Chinese, Europeans, and persons of mixed heritage. More than half of the population live in the Society Islands. About half of the population is less than 20 years old and slightly more than 5% is older than 60. Due to a recent decline in fertility, the rate of natural increase is moderate--about 2.5% annually. In the early 1980s, about two thirds of women in Tahiti aged 15-49 used a modern method of contraception. It remains to be seen whether this pattern will spread to the entire area. Projections by the World Bank, assuming little decline in mortality, yield a total population of 400,000 by the year 2030. The major challenge for French Polynesia is to develop the many small islands spread across an ocean territory half the size of the contiguous 48 states of the U.S. Tourist-related activities have replaced traditional income-generating such as production of coconuts, mother-of-pearl, and vanilla. The value of exports from the area make up only 5% of the value of imports. To extract the potentially huge food and mineral resources from the ocean, enormous infusions of capital will be necessary.

  11. Gout in the spotlight.

    Science.gov (United States)

    So, Alexander

    2008-01-01

    Understanding how uric acid crystals provoke inflammation is crucial to improving our management of acute gout. It is well known that urate crystals stimulate monocytes and macrophages to elaborate inflammatory cytokines, but the tissue response of the synovium is less well understood. Microarray analysis of mRNA expression by these lining cells may help to delineate the genes that are modulated. Employing a murine air-pouch model, a number of genes expressed by innate immune cells were found to be rapidly upregulated by monosodium urate crystals. These findings provide new research avenues to investigate the physiopathology of gouty inflammation, and may eventually lead to new therapeutic targets in acute gout.

  12. Molecules in the Spotlight

    Energy Technology Data Exchange (ETDEWEB)

    Cryan, James

    2010-01-26

    SLAC has just unveiled the world's first X-ray laser, the LCLS. This machine produces pulses of X-rays that are ten billion times brighter than those from conventional sources. One of the goals of this machine is to make movies of chemical reactions, including reactions necessary for life and reactions that might power new energy technologies. This public lecture will show the first results from the LCLS. As a first target, we have chosen nitrogen gas, the main component of the air we breathe. Using the unprecedented power of the LCLS X-rays as a blasting torch, we have created new forms of this molecule and with unique electronic arrangements. Please share with us the first insights from this new technology.

  13. Spotlight on Spelling.

    Science.gov (United States)

    Hardin County Board of Education, Elizabethtown, KY.

    Word lists and class activities are suggested for improving the spelling of elementary school students. The word lists contain rhyming words, antonyms, synonyms, homonyms, 100 spelling demons, look-alike words that are easily confused, and content area words (for geography, mathematics, science, sports, music, social studies). The suggested…

  14. Spotlight on Solutions.

    Science.gov (United States)

    Spoor, Dana L.

    1997-01-01

    Presents interviews with five school administrators, representing a variety of school systems. Discusses their strategies for addressing concerns that all school systems share. Using a question and answer format, the article focuses on handicap accessibility, energy management, funding, security, and technology. (RJM)

  15. Sri Lanka. Spotlight.

    Science.gov (United States)

    Hoque, M N

    1985-01-01

    Sri Lanka, an island country off the southeastern coast of India, populated by an estimated 16.1 million inhabitants, was one of the 1st developing countries to adopt a population policy aimed at reducing population growth and redistributing the population more equitably throughout the country. Population density is high. There are 636 persons/square mile, and 2/3 of the population lives in the southwestern and central regions of the country. Government redistribution policies seek to increase internal migration flows to the drier and less populated areas. The country's birth rate was 27 in 1982, the death rate was 6 in 1981, and the infant mortality rate was 34.4 in 1980. The rate of natural increase in 1982 was 2.1%, and the population growth rate declined from 2.5% prior to 1970 to 1.7% in 1980. The total fertility rate declined between 1963-74 from 5.0-3.4 and then increased to 3.7 in recent years. Given the age structure of the population, the population is expected to continue growing at a high rate in the coming years; however, the age at marriage is increasing and the proportion of young married women in the population is declining, and these trends will have an impact on population growth. These trends are due in part to increased educational and employment opportunities for women. The delay in marriage may also be linked to the dowry system. Given the high rate of poverty, it is difficult for parents to accummulate sufficient resources to provide dowries for their daughters. Sri lanka's economy is predominantly agricultural, with only 15% of the gross national product derived from manufacturing. Approximately 22% of thepopulation lives in urban areas. In 1981 exports totaled US$1.1 billion, and major export items were tea and rubber. In the same year, imports totaled US$1.8 billion and consisted primarily of food, petroleum, and fertilizers. The per capita gross national product was US$320 in 1982. Sri Lanka receives considerable foreign aid, and the country's family planning program receives substantial outside support.

  16. Spotlight on NHS labs

    International Nuclear Information System (INIS)

    Glover, Bryn

    1988-01-01

    A brief article examines a small group of national health service workers who may encounter the AIDS virus, reviews the changes they have devised to minimize the risks to themselves and considers the obstacles that remain to prevent the full implementation of these changes. The article also discusses the importance of reducing the radiation dose limits for workers. Ways of reducing occupational exposure of personnel involved in radiology, nuclear medicine and radiotherapy are described. It is argued that cash limits should never compromise worker safety. (U.K.)

  17. Spotlight on Peru.

    Science.gov (United States)

    1997-01-01

    Lima's population grew from 1 million to 7 million during 1969-89, almost entirely due to rural-urban immigration. Other urban areas such as Iquitos experienced similar growth over the period. National, regional, and municipal governments have been working to restore civil order in the country and to bring basic health, sanitation, and education programs to the population. However, language, attitudinal, and cultural differences impede progress in this diverse and changing country. Peru's young population of median age 21 years presents a challenge to the development and implementation of effective reproductive health care programs for the country. Pathfinder's work in Peru is helped by current President Alberto Fujimori's strong and active support for family planning. In the face of strong opposition from the Roman Catholic Church, President Fujimori has held onto his conviction and commitment to reduce levels of maternal morbidity and mortality in Peru by increasing the accessibility of family planning programs. Pathfinder's work in Peru with the US Agency for International Development (USAID) includes the 5-year program Project 2000 designed to improve maternal and child health in 12 priority regions of the country. Pathfinder is also working with USAID to link family planning to postpartum services in 30 public hospitals throughout the country. New programs will be launched with contributions from individuals and foundations.

  18. Evaluación estructural y rehabilitación sísmica del Hotel Samarina de propiedad de la Universidad Península de Santa Elena, para la creación de un modelo disipador de energía.

    Directory of Open Access Journals (Sweden)

    Armando Saltos

    2015-12-01

    Full Text Available El Hotel Samarina está ubicado frente al mar, en la cota +12 m s.n.m., en el cantón La Libertad, Provincia de Santa Elena. Fue construido al final de la década de los 50. El hotel Samarina terminado en un 70%, se compone de planta baja y tres pisos altos y estructuras de hormigón armado. La superficie total del mencionado hotel es de 2638 m2. Actualmente, se conoce que en el Ecuador y principalmente en la Provincia de Santa Elena, presenta una alta sismicidad por estar ubicada cercana a la zona de subducción de la placa de nazca y la placa sudamericana. A través de una evaluación y diagnóstico estructural, conforme a las normas ecuatorianas NEC 2011 o códigos uniformes de edificación UBC 97 la actual edificación no cumple el diseño sismoresistente, y de acuerdo al conocimiento actual se elaboró un diseño moderno donde se mejoró su nivel de desempeño o comportamiento sismo resistente ante la acción de un sismo moderado, y con la aplicación de un software libre denominado ETAB's se implementó un modelo con sistema de reforzamiento, compuesto de disipadores de energía colocados en las caras laterales y reforzamiento de columnas en los cuatro niveles que componen el edificio.   ABSTRACT The Samarina Hotel is located close to the sea, at 12 m s.n.m., at La Libertad, Province of Santa Elena. It was constructed at the end of the decade of the 50. The hotel has a ground floor and three high floors and it has reinforced concrete structures with surface of 26382. In the Ecuador and principally at Province of Santa Elena, has a high seismicity conditions because of it are located near to the zone of subduction of the Nazca South plates. An evaluation and structural diagnosis was performed, according to NEC 2011 proceeding, and also with the uniform codes of building UBC97. It is important to indicate that the actual building does not fulfill the design seismic resistant requirements. To improve the level resistant earthquake was

  19. Estudio de Factibilidad Técnico-Económico y Financiero para la Construcción de una Estación de Gas Natural y un Taller de Conversión Vehicular en la Provincia de Santa Elena

    OpenAIRE

    Espol; Marmol Hermosa, Daniel; Rivera Briones, José

    2015-01-01

    El proyecto consiste en construir una estación de servicio que expenda gas natural a los taxis de la provincia de Santa Elena adicionalmente propone construir un taller donde se ofrecerá el servicio de instalación y mantenimientos del kit, que permita usar el gas natural como combustible alternativo a la gasolina. El gas natural es el hidrocarburo que produce en los motores la combustión más limpia. Guayaquil Magíster en Gestión de Proyectos

  20. Mapping Tropical Rainforest Canopy Disturbances in 3D by COSMO-SkyMed Spotlight InSAR-Stereo Data to Detect Areas of Forest Degradation

    Directory of Open Access Journals (Sweden)

    Manuela Hirschmugl

    2013-02-01

    Full Text Available Assessment of forest degradation has been emphasized as an important issue for emission calculations, but remote sensing based detecting of forest degradation is still in an early phase of development. The use of optical imagery for degradation assessment in the tropics is limited due to frequent cloud cover. Recent studies based on radar data often focus on classification approaches of 2D backscatter. In this study, we describe a method to detect areas affected by forest degradation from digital surface models derived from COSMO-SkyMed X-band Spotlight InSAR-Stereo Data. Two test sites with recent logging activities were chosen in Cameroon and in the Republic of Congo. Using the full resolution COSMO-SkyMed digital surface model and a 90-m resolution Shuttle Radar Topography Mission model or a mean filtered digital surface model we calculate difference models to detect canopy disturbances. The extracted disturbance gaps are aggregated to potential degradation areas and then evaluated with respect to reference areas extracted from RapidEye and Quickbird optical imagery. Results show overall accuracies above 75% for assessing degradation areas with the presented methods.

  1. Application of the EGM Method to a LED-Based Spotlight: A Constrained Pseudo-Optimization Design Process Based on the Analysis of the Local Entropy Generation Maps

    Directory of Open Access Journals (Sweden)

    Enrico Sciubba

    2011-06-01

    Full Text Available In this paper, the entropy generation minimization (EGM method is applied to an industrial heat transfer problem: the forced convective cooling of a LED-based spotlight. The design specification calls for eighteen diodes arranged on a circular copper plate of 35 mm diameter. Every diode dissipates 3 W and the maximum allowedtemperature of the plate is 80 °C. The cooling relies on the forced convection driven by a jet of air impinging on the plate. An initial complex geometry of plate fins is presented and analyzed with a commercial CFD code that computes the entropy generation rate. A pseudo-optimization process is carried out via a successive series of design modifications based on a careful analysis of the entropy generation maps. One of the advantages of the EGM method is that the rationale behind each step of the design process can be justified on a physical basis. It is found that the best performance is attained when the fins are periodically spaced in the radial direction.

  2. Proidi tsherez "igolnoje ushko" / Elena Rudi

    Index Scriptorium Estoniae

    Rudi, Elena

    2007-01-01

    Tallinnas avati pidulikult taastatud Trepi tänav Nõelasilma väravaga. Taastatud väravaehitist ilmestab vanast väravast säilinud barokkstiilis raidreljeef. Taastamisprojekti autor on restauraator Marek Lill

  3. Mejoramiento de las capacidades lingüísticas en el idioma inglés a través de la modalidad Blended Learning para el personal docente de la universidad estatal península de santa elena en el período académico 2015 - 2016

    Directory of Open Access Journals (Sweden)

    Xavier Almeida

    2015-10-01

    This article is the result of teamwork by the Research Team of The English Teaching Career at Peninsula of Santa Elena State University  “U P S E ”.  The basis of this publication is the previous research done by the English career in the years 2012 - 2013.  From this work important data has been selected exclusively from the part in which educators manifested their interest in improving their English competence with the Blended Learning System which offers flexible schedules and classes. There is also an approved project to be executed in the year 2015-2016.  Using these two previous papers as reference this article has been written.

  4. Joyful Food. Spotlight: Physical Development.

    Science.gov (United States)

    Stratton, Mary

    2000-01-01

    Presents suggestions for integrating food experiences as a positive, sustaining part of the family lifestyle. Focuses on social graces and rituals related to special family meals and gatherings, on using tea parties to integrate family rituals and etiquette, and on family gardening. Describes ways children can participate in food acquisition and…

  5. CURE Scholar Spotlight - Dr. Brady

    Science.gov (United States)

    Donita C. Brady, a Research Associate Senior at the Department of Pharmacology and Cancer Biology at Duke University, is investigating the role that copper plays in cell growth and tumor biology. Inspired by her mentor Christopher Counter, a cancer biologist, and Dennis Thiele, a copper biologist, at Duke University, Brady has a unique interest in the way copper interacts with protein pathways, such as the BRAF (a human gene that directs cell growth)-MEK-ERK pathway, which is a major target for targeted cancer therapies because the BRAF gene is mutated 60% of the time in melanoma.

  6. Refugee scientists under the spotlight

    Science.gov (United States)

    Extance, Andy

    2017-07-01

    Thousands of people are forced to flee war-torn regions every year, but the struggles of scientists who have to leave their homeland often goes under the radar. Andy Extance reports on initiatives to help

  7. Neutrino physics in the spotlight

    CERN Multimedia

    2009-01-01

    Following on from the Council recommendation made in Lisbon in 2006 and responding to the needs of a large community of scientists, CERN will organize the European Strategy for Future Neutrino Physics workshop on 1-3 October. One of the main goals of the workshop is to start establishing a roadmap for the coherent participation of Europe in neutrino physics."The format of the workshop will consist of invited talks to present the current situation and future possibilities; unlike other workshops, 30% of the time will be reserved for discussion", explains Ewa Rondio from the organising committee. "Resources for future neutrino experiments will be difficult to acquire. A coordinated approach and the participation of a large community of interested scientists are undoubtedly crucial factors". The workshop will be the opportunity to highlight the areas where substantial research and development activities are required in order to design the facilities of the next decade. "The w...

  8. Spotlight on modern transformer design

    CERN Document Server

    Georgilakis, Pavlos S

    2009-01-01

    Increasing competition in the global transformer market has put tremendous responsibilities on the industry to increase reliability while reducing cost. This book introduces an approach to transformer design using artificial intelligence (AI) techniques in combination with finite element method (FEM).

  9. Spotlight on quantum black holes

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    Particle theorists are getting unusually excited these days as new ideas and different approaches converge in the search for a picture which describes all the underlying mechanisms of Nature. Although the final picture has yet to emerge, the outline is becoming clearer. While the intellectual mountain range to be crossed was once intimidating, these new developments are beginning to point to a way over. A series of recent topical workshops have highlighted these developments and leap-frogged ahead - including String 95 at the University of Southern California, Los Angeles, this spring and a conference on Mirror Symmetry and S-duality held in June at Trieste's International Centre for Theoretical Physics. Closing the Trieste meeting, prominent theorist Ed Witten said ''this is one of the most exciting conferences in which I have ever participated''. With profound problems to be overcome, the new ideas now on the market at first look very unconventional. Classical electromagnetism exploits the parallels between electricity and magnetism but accepts the everyday wisdom that free magnetic charges (magnetic monopoles) do not exist. Particle theorists are not so sure, and for a long time magnetic monopoles have been tentatively included on the theoretical menu. The role of these monopoles has now become crucial. Also playing a central role is the idea of supersymmetry. In a quantum theory, basic particles, like quarks and leptons (fermions), interact through force-carrying particles (bosons) like the photon of electromagnetism, the W and Z of the weak nuclear force and the gluon of the strong inter-quark force. In supersymmetry, each fermion has additional boson partners, and vice versa. So far, no evidence for supersymmetry has been found, but the underlying ideas are so convincing that its existence is almost taken for granted among theorists. Supersymmetry would have governed the mechanics of the Big Bang, but as the temperature fell, supersymmetry 'froze' out and became almost invisible. In the late 1970s, Klaus Montonen and David Olive pointed out that if magnetic monopoles are included in a supersymmetric quantum picture, the electric and magnetic sectors are in some respects mutually complementary. Magnetic charges provide additional calculational leverage, sidestepping the traditional problem of having to solve the equations of the theory through sometimes unsatisfactory approximations. Subsequently, the ideas were enlarged to include 'dyons' - particles having both electric and magnetic charges, providing a much richer scenario

  10. CERN communication in the spotlight

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    A rich harvest of important prizes has recently been awarded to CERN communication efforts. The list includes: the European Excellence Award 2010, the physics.org “people’s choice” award for the best children's website, and two prizes in the UK Recruitment Advertising Awards for 2011. Given the high expectations surrounding CERN's future physics results, there is little doubt that the old refrain “the best is yet to come” also applies to communication at CERN.   Marie Anne Bugnon and Antonella del Rosso, from the Communication Group, accept the 2010 European Excellence Award for LHC First Physics. In recent years, efforts to communicate as much and as well as possible have been stepped up at CERN – across all communities – and the fruits have come little by little. First of all, awards represent the recognition of the public, which, on different levels, has shown that it appreciates CERN’s efforts to...

  11. Spotlight on medicinal chemistry education.

    Science.gov (United States)

    Pitman, Simone; Xu, Yao-Zhong; Taylor, Peter; Turner, Nicholas; Coaker, Hannah; Crews, Kasumi

    2014-05-01

    The field of medicinal chemistry is constantly evolving and it is important for medicinal chemists to develop the skills and knowledge required to succeed and contribute to the advancement of the field. Future Medicinal Chemistry spoke with Simone Pitman (SP), Yao-Zhong Xu (YX), Peter Taylor (PT) and Nick Turner (NT) from The Open University (OU), which offers an MSc in Medicinal Chemistry. In the interview, they discuss the MSc course content, online teaching, the future of medicinal chemistry education and The OU's work towards promoting widening participation. SP is a Qualifications Manager in the Science Faculty at The OU. She joined The OU in 1993 and since 1998 has been involved in the Postgraduate Medicinal Chemistry provision at The OU. YX is a Senior Lecturer in Bioorganic Chemistry at The OU. He has been with The OU from 2001, teaching undergraduate courses of all years and chairing the master's course on medicinal chemistry. PT is a Professor of Organic Chemistry at The OU and has been involved with the production and presentation of The OU courses in Science and across the university for over 30 years, including medicinal chemistry modules at postgraduate level. NT is a Lecturer in Analytical Science at The OU since 2009 and has been involved in the production of analytical sciences courses, as well as contributing to the presentation of a number of science courses including medicinal chemistry.

  12. School Shootings in Policy Spotlight

    Science.gov (United States)

    Maxwell, Lesli A.

    2006-01-01

    The three school shootings that left a principal and six students dead in less than a week have sparked a barrage of pledges from national and state political leaders to tighten campus security. School safety experts urged caution against overreacting to the horrific, but rare, incidents in rural schools in Colorado, Pennsylvania, and Wisconsin.…

  13. Get prepared for the spotlight

    CERN Multimedia

    2009-01-01

    With the re-start of the LHC, not just the scientific community will have its eyes on CERN. Hundreds of journalists will continue to ensure high media coverage of the Lab’s activities. As the DG stated in his message in issue No.15 of The Bulletin, "we have a greater degree of responsibility in the way we communicate". The Media Training organized by the Press Office gives you the chance to learn how to do it.If you are a scientist, engineer, computer expert or in any way a person likely to interact with the media, you might get the chance to be involved in the activities of the Press Office, which welcomes over 500 journalists from all over the world every year. "We are looking for enthusiastic scientists, researchers, engineers and IT specialists who are eager to explain their work to journalists", explains Renilde Vanden Broeck, Press Officer. "Last year we dealt with more than 700 media on-site. A regular media visit covers the main activities of CERN, namely accelerat...

  14. Interpreting Bodies. Elena Castellani (ed.) Interpreting Bodies: Classical and Quantum Objects in Modern Physics (Princeton: Princeton University Press, 1998), viii+329 pp., ISBN 0-691-01725-5, paperback, 19.95 US, ISBN 0-691-01724-7, cloth, 65.00 US.

    Science.gov (United States)

    Ruetsche, Laura

    The objects of the empirical science known as particle physics are not like objects ordinarily conceived. Physicists' particles can enter states strangely entangled with those of other particles; they can obey statistics which suggest that they lack genidentity; their properties (some think) are created in measurement, or (others think) can only be limned from the symmetries of the theory describing them. 'The implications of contemporary physical theories for the debate on the nature of objects' provides 'the central theme' (p. 4) of Interpreting Bodies, editor Elena Castellani's new collection of essays. Contributions to the volume vary dramatically in vintage (Born's and Reichenbach's are well into middle age; others appear here for the first time); in approach (the collection includes Giuliano Toraldo diFrancia's nine-page history of the object concept from Democritus to d'Espagnat, Peter Mittelstaedt's discussion of the Kantian constitution of quantum objects, and Giulo Peruzzi's explication of the scattering cross section and its role in experimental particle physics); and in intended audience. Lacking the space to treat each contribution in turn, I will focus on those dealing with the problem of the One and the Many.

  15. Investigation on the separability of slums by multi-aspect TerraSAR-X dual-co-polarized high resolution spotlight images based on the multi-scale evaluation of local distributions

    Science.gov (United States)

    Schmitt, Andreas; Sieg, Tobias; Wurm, Michael; Taubenböck, Hannes

    2018-02-01

    Following recent advances in distinguishing settlements vs. non-settlement areas from latest SAR data, the question arises whether a further automatic intra-urban delineation and characterization of different structural types is possible. This paper studies the appearance of the structural type ;slums; in high resolution SAR images. Geocoded Kennaugh elements are used as backscatter information and Schmittlet indices as descriptor of local texture. Three cities with a significant share of slums (Cape Town, Manila, Mumbai) are chosen as test sites. These are imaged by TerraSAR-X in the dual-co-polarized high resolution spotlight mode in any available aspect angle. Representative distributions are estimated and fused by a robust approach. Our observations identify a high similarity of slums throughout all three test sites. The derived similarity maps are validated with reference data sets from visual interpretation and ground truth. The final validation strategy is based on completeness and correctness versus other classes in relation to the similarity. High accuracies (up to 87%) in identifying morphologic slums are reached for Cape Town. For Manila (up to 60%) and Mumbai (up to 54%), the distinction is more difficult due to their complex structural configuration. Concluding, high resolution SAR data can be suitable to automatically trace potential locations of slums. Polarimetric information and the incidence angle seem to have a negligible impact on the results whereas the intensity patterns and the passing direction of the satellite are playing a key role. Hence, the combination of intensity images (brightness) acquired from ascending and descending orbits together with Schmittlet indices (spatial pattern) promises best results. The transfer from the automatically recognized physical similarity to the semantic interpretation remains challenging.

  16. GDA sinu abimees pakendil / Piret Jaaks ; kommenteerinud Elena Burm

    Index Scriptorium Estoniae

    Jaaks, Piret, 1980-

    2010-01-01

    Euroopa Komisjoni kokku kutsutud toitumisteadlaste komisjoni Eurodiet poolt koostatud GDA toitumisjuhist toiduainepakenditel, mis aitab jälgida toote- või joogiportsjoni osatähtsust päevasest soovitatavast kalorite ning olulisemate toitainete kogusest

  17. Life without centrioles: cilia in the spotlight.

    Science.gov (United States)

    Badano, Jose L; Katsanis, Nicholas

    2006-06-30

    Centrioles are critical cellular components that form the architectural core of both centrosomes and basal bodies, the nucleating structures of cilia. New work, including a study in this issue (), highlights the unexpected finding that lack of centrioles does not impede development in the fruit fly. Rather, flies reach maturity but then die because their sensory neurons lack cilia.

  18. 10 September: CERN in the media spotlight

    CERN Multimedia

    2008-01-01

    Media organisations around the world are holding their breath in anticipation for the moment the LHC circulates its first proton beam. On 10 September, the Globe and the experiment control rooms will not only be packed full of eager physicists and electrical engineers, but also journalists. Their aim? Capturing the first moments in the life of the LHC and beaming it around the world for millions of people to see! "Almost 250 journalists from 33 countries will be here on 10 September. The start-up of the LHC is not just a scientific landmark, but a news story that captures the imagination of people everywhere," comments James Gilles, the Communication Group leader. A media centre will be set up in the Globe along with a large screen showing the activity in the CCC. Throughout the day a member of the operations team will be on hand to explain what is happening. The first injection of the beam into the machine will be between 9:00 and 10:00 a. m., with the main objective...

  19. Fat & fabulous: bifunctional lipids in the spotlight.

    Science.gov (United States)

    Haberkant, Per; Holthuis, Joost C M

    2014-08-01

    Understanding biological processes at the mechanistic level requires a systematic charting of the physical and functional links between all cellular components. While protein-protein and protein-nucleic acid networks have been subject to many global surveys, other critical cellular components such as membrane lipids have rarely been studied in large-scale interaction screens. Here, we review the development of photoactivatable and clickable lipid analogues-so-called bifunctional lipids-as novel chemical tools that enable a global profiling of lipid-protein interactions in biological membranes. Recent studies indicate that bifunctional lipids hold great promise in systematic efforts to dissect the elaborate crosstalk between proteins and lipids in live cells and organisms. This article is part of a Special Issue entitled Tools to study lipid functions. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. National Minority Health Month Spotlight: Career Development

    Science.gov (United States)

    April is National Minority Health Month and in support of the 2016 theme, Accelerating Health Equity for the Nation, the NCI Center to Reduce Cancer Health Disparities (CRCHD) is highlighting how diversity training and career development opportunities are contributing to efforts to reduce the unequal burden of cancer in our society.

  1. Chaperonopathies: spotlight on hereditary motor neuropathies

    Directory of Open Access Journals (Sweden)

    Vincenzo Lupo

    2016-12-01

    Full Text Available Distal hereditary motor neuropathies (dHMN comprise a group of rare hereditary neuromuscular disorders characterized by a peroneal muscular atrophy without sensory symptoms. To date twenty-three genes for dHMN have been reported and four of them encode for chaperones: DNAJB2, which encodes a member of the HSP40/DNAJ co-chaperone family, and HSPB1, HSPB3 and HSPB8, which encode three members of the family of small heat shock proteins. Except for HSPB1, with around thirty different mutations, the remaining three genes comprise a much low number of cases. Thus, only one case has been described caused by an HSPB3 mutation, whereas few DNAJB2 and HSPB8 cases are known, most of them caused by a founder c.352+1G>A mutation in DNAJB2 and by mutations affecting the hot spot K141 residue of the HSPB8 chaperone. This low number of cases makes it difficult to understand the pathomechanism underlying the neuropathy. Chaperones can assemble in multi-chaperone complexes forming an integrative chaperone network in the cell, which plays relevant cellular roles in a variety of processes such as the correct folding of newly synthesized proteins, their escort to their precise cellular locations to form functional proteins and complexes and the response to protein misfolding, including the degradation of proteins that fail to refold properly. Despite of this variety of functions, mutations in some of them lead to diseases with a similar clinical picture, suggesting common pathways. This review gives an overview of the genetics of dHMNs caused by mutations in four genes, DNAJB2, HSPB1, HSPB3 and HSPB8, which encode chaperones and show a common disease mechanism.

  2. Oxidative damage and aging: spotlight on mitochondria.

    Science.gov (United States)

    Linford, Nancy J; Schriner, Samuel E; Rabinovitch, Peter S

    2006-03-01

    Whereas free radical damage has been proposed as a key component in the tissue degeneration associated with aging, there has been little evidence that free radical damage limits life span in mammals. The current research shows that overexpression of the antioxidant enzyme catalase in mitochondria can extend mouse life span. These results highlight the importance of mitochondrial damage in aging and suggest that when targeted appropriately, boosting antioxidant defenses can increase mammalian life span.

  3. Spotlight on acupuncture in laboratory animal medicine

    Directory of Open Access Journals (Sweden)

    Magden ER

    2017-08-01

    Full Text Available Elizabeth R Magden Department of Veterinary Sciences, Michale E Keeling Center for Comparative Medicine and Research, University of Texas MD Anderson Cancer Center, Bastrop, TX, USA Abstract: Acupuncture has been practiced for thousands of years, although it is only in the past century that science has worked to unravel the mechanisms behind its use. Literature supporting the efficacious use of acupuncture to treat a variety of conditions has been and continues to be published, including the randomized controlled studies we all appreciate when practicing evidence-based medicine. The use of acupuncture in veterinary medicine has paralleled the trends observed in people, with an increasingly common use to remedy specific medical conditions. These conditions are commonly related to neurological dysfunction or orthopedic pain. Although pain relief is the most common use of acupuncture, numerous other conditions have been shown to improve with this therapy. Laboratory animals are also benefiting from acupuncture. Its use is starting to be incorporated into research settings, although there is still further progress to be made in this field. Acupuncture has been shown to improve clinical conditions and quality of life in laboratory animals, and should be considered as a tool to treat laboratory animals with conditions known to benefit from therapy. Here we review the history, mechanisms of action, and use of acupuncture to treat veterinary patients and laboratory animals. Keywords: acupuncture, laboratory animals, nonhuman primates

  4. Spotlight on daytime napping during early childhood

    Directory of Open Access Journals (Sweden)

    Horváth K

    2018-03-01

    Full Text Available Klára Horváth,1 Kim Plunkett2 12nd Department of Pediatrics, Semmelweis University, Budapest, Hungary; 2Department of Experimental Psychology, University of Oxford, Oxford, UK Abstract: Daytime napping undergoes a remarkable change in early childhood, and research regarding its relationship to cognitive development has recently accelerated. In this review, we summarize our current understanding of this relationship focusing on children aged <5 years. First, we evaluate different studies on the basis of the experimental design used and the specific cognitive processes they investigate. Second, we analyze how the napping status of children may modulate the relationship between learning and napping. Third, the possible role of sleep spindles, ie, specific electroencephalographic components during sleep, in cognitive development is explored. We conclude that daytime napping is crucial in early memory development. Keywords: napping, children, infants, cognitive development, daytime sleep, memory, language development, sleep spindles

  5. Spotlight on daytime napping during early childhood.

    Science.gov (United States)

    Horváth, Klára; Plunkett, Kim

    2018-01-01

    Daytime napping undergoes a remarkable change in early childhood, and research regarding its relationship to cognitive development has recently accelerated. In this review, we summarize our current understanding of this relationship focusing on children aged napping status of children may modulate the relationship between learning and napping. Third, the possible role of sleep spindles, ie, specific electroencephalographic components during sleep, in cognitive development is explored. We conclude that daytime napping is crucial in early memory development.

  6. Spotlight on daytime napping during early childhood

    OpenAIRE

    Horváth,Klára; Plunkett,Kim

    2018-01-01

    Klára Horváth,1 Kim Plunkett2 12nd Department of Pediatrics, Semmelweis University, Budapest, Hungary; 2Department of Experimental Psychology, University of Oxford, Oxford, UK Abstract: Daytime napping undergoes a remarkable change in early childhood, and research regarding its relationship to cognitive development has recently accelerated. In this review, we summarize our current understanding of this relationship focusing on children aged <5 years. First, we eva...

  7. The ATLAS cavern in the spotlight

    CERN Multimedia

    On Wednesday, 4th June, the President of the Swiss Confederation, Pascal Couchepin, inaugurated the world's largest experimental cavern, which is to house the ATLAS detector in 2007, and announced Switzerland's gift to CERN of the "Palais de l'Equilibre".

  8. International Geneva: intellectual property under the spotlight

    CERN Multimedia

    Antonella Del Rosso

    2015-01-01

    On 17 July, the Director-General of the World Intellectual Property Organization (WIPO), Francis Gurry, will present his organisation to CERN people. You are invited to take part and discover the UN’s specialised agency for services, policy, information and cooperation relating to intellectual property.   This is the third in the “International Geneva comes to CERN” series of seminars, which presents other Geneva-based international organisations to CERN’s internal audience. In his seminar, Gurry will discuss how WIPO finds the right balance between the interests of innovators and the wider public and how the IP system aims to foster an environment in which creativity and innovation can flourish. In 2010, CERN and WIPO signed a collaboration agreement designed to strengthen the partnership between the two organisations. The agreement focused on four main areas for cooperation, namely: capacity building, awareness raising and knowledge sharing; tra...

  9. Spotlight on GME/GHSE Supported Research

    Science.gov (United States)

    2017-12-07

    hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and...utilize Pyrosequencing for their Protocol. Genetic Status of Genes via PCR & NGS ... 3.000.000.000bp 1 __ ____ _ 0_ .. -··. _ Ll...Construct Exome library for NGS . Sequence Exome via NGS . Store Exome data for future studies 1 bp 30,000,000 bp PCR DATA NGS DATA C

  10. Fatal attraction: rare species in the spotlight.

    Science.gov (United States)

    Angulo, Elena; Deves, Anne-Laure; Saint Jalmes, Michel; Courchamp, Franck

    2009-04-07

    The exploitation of rare and endangered species can end in the species's extinction because the increased value people associate with rarity increases the economic incentive to exploit the last individuals, creating a positive feedback loop. This recently proposed concept, called the anthropogenic Allee effect (AAE), relies on the assumption that people do value rarity, but this remains to be established. Moreover, it also remains to be determined whether attraction to rarity is a trait confined to a minority of hobbyists (e.g. wildlife collectors, exotic pet owners) or characteristic of the general public. We estimated how much the general public valued rare species compared with common ones, using five different metrics related to personal investment: time spent, physical effort, unpleasantness, economic investment and risk. We surveyed the visitors of a zoo. To see the rare species, the visitors to the zoo invested more time in searching and contemplation, they were ready to expend more physical effort, they tolerated more unpleasant conditions, they were willing to pay more and, finally, they risked more to obtain (steal) a rare species. Our results provide substantial evidence of how the general public places more value on rare species, compared with common species. This confirms the AAE as an actual process, which in addition concerns a large part of the population. This has important consequences for the conservation of species that are rare now, or that could become so in the future.

  11. Early Reading Proficiency. Leading Indicator Spotlight

    Science.gov (United States)

    Musen, Lindsey

    2010-01-01

    In "Beyond Test Scores: Leading Indicators for Education," Foley and colleagues (2008) define leading indicators as those that "provide early signals of progress toward academic achievement" (p. 1) and stress that educators "need leading indicators to help them see the direction their efforts are going in and to take…

  12. Madagascar's open landscapes under the spotlight

    African Journals Online (AJOL)

    species and more than 80% of the bird and amphibian species found in Madagascar existing only in forest habitats (Goodman ... Madagascar is rich in fresh-water wetlands .... rural population can help to provide best practices that preserve.

  13. Turning the spotlight: Looking at the interviewers

    DEFF Research Database (Denmark)

    Sørensen, Randi Skovbjerg

    questions with quantitative, qualitative, and C A inspired analyses: How do two interviewers behave in the sociolinguistic interviews which they themselves classify as good or bad interviews? And how does this relate to their own ideals for the sociolinguistic interview? How is it possible to approach...... interviews. For instance, the interviewers tend to take more of the initiatives to change the topic and ask more questions in their bad interviews than in their good interviews. Further studies of the female interviewer's best and worst interview show that rapport is achieved in her best but spoiled in her...... to questions. The studies make it clear that success and failure is not just one thing. The studies reveal great complexity and confirm that there are differences between the interviewers' best and worst interviews as well as between the two interviewers. Studying four interviews of each of the two...

  14. Spotlight census of the red fox (Vulpes vulpes and the domestic cat (Felis catus in three sample areas of the Marches region (Central Italy / Censimento notturno di Volpe (Vulpes vulpes e di Gatto domestico (Felis catus in tre aree campione delle Marche

    Directory of Open Access Journals (Sweden)

    Massimo Pandolfi

    1991-07-01

    Full Text Available Abstract In order to evaluate the density of the red fox and of the domestic cat, 55 transects were made from 1986 to 1989 using spotlight census method in three sample areas. The mean density of foxes agreed substantially with its biological cycle and the hightes values (2.01 foxes/km² in spring and 4.3 foxes/km² in winter were recorded in the study area with the better natural characteristics. Foxes selected the shrub woodland (macchia all year round, the inhabited area in spring. The domestic cat was widely spread and abundant, and selected especially inhabited areas where the density varied from 4.27 cats/km² (in winter to 12.42 cat/km² (in spring. Riassunto Dal 1986 al 1989, con il metodo dei percorsi notturni con fari, sono stati effettuati complessivamente 55 conteggi in tre aree campione per valutare la densità della Volpe (Vulpes vulpes e del Gatto domestico (Felis catus nonché le loro preferenze ambientali limitatamente ad una zona campione. Per la Volpe le densità medie rilevate sono sostanzialmente in accordo con il ciclo biologico della specie e quelle più elevate (2,O1 volpi/km² in primavera e 4,3 volpi/km² in inverno sono state registrate nella zona campione con maggior presenza di boschi ed aree incolte. La Volpe seleziona le zone con vegetazione "di macchia" in ogni periodo dell'anno, e le aree abitate in primavera. Per il Gatto domestico le densità rilevate evidenziano la presenza di una diffusa ed abbondante popolazione. La specie mostra una spiccata preferenza per le aree abitate dove raggiunge densità di 4,27 individui/km² e 12,42 individui/km² in inverno e primavera rispettivamente.

  15. Presentación. Alberto Elena y las miradas a los cines periféricos / Presentation. Alberto Elena and the Views on Peripheral Cinemas

    Directory of Open Access Journals (Sweden)

    Minerva Campos

    2016-12-01

    Full Text Available «Llegará un día en que el cine habrá cambiado el mundo más que la invención de la pólvora, la electricidad o el descubrimiento de nuevos continentes. El cine permitirá a la gente repartida por los más remotos confines de la Tierra conocerse y apreciarse mejor. El cine reconciliará las diferencias de opinión y contribuirá de forma decisiva a la realización de los ideales de la Humanidad. Es fundamental que concedamos al cine la importancia que merece». Mustafa Kemal Atatürk (1937

  16. Implantación de guías de buenas prácticas en España. Programa de centros comprometidos con la excelencia en cuidados / Best Practice Guidelines Implementation in Spain. Best Practice Spotlight Organizations / Implementação de manuais sobre boas práticas na Espanha. Programa dos Centros comprometidos com a excelência no atendimento

    Directory of Open Access Journals (Sweden)

    Laura Albornos-Muñoz, BS.

    2015-03-01

    Full Text Available Introducción: El programa de implantación de Guías de Buenas Prácticas, denominado en España Centros Comprometidos con la Excelencia en Cuidados®, se inició en 2010 tras un acuerdo de colaboración entre la Unidad de Investigación en Cuidados de Salud (Investén-isciii de España, el Centro Colaborador Español del Instituto Joanna Briggs para los Cuidados de Salud basados en la Evidencia y la Registered Nurses' Association of Ontario (RNAO, siguiendo los mismos principios que el programa Best Practice Spotlight Organizations (BPSO® iniciado por RNAO, en Canadá, en 1999. Objetivo: Describir la implantación de Guías de Buenas Prácticas de RNAO en el marco del programa de Centros Comprometidos con la Excelencia en Cuidados® (Best Practice Spotlight Organizations® en España. El programa tiene como objetivo fomentar, facilitar y apoyar la implantación, evaluación y mantenimiento de buenas prácticas en cuidados, para el periodo 2012-2014. Metodología y Resultados: se han seleccionado 8 instituciones de salud y una universidad que implantan las guías de buenas prácticas de RNAO en función de sus necesidades. Tras los 24 primeros meses de implantación se ha formado a los profesionales de salud, constituido grupos estables de trabajo, desarrollado o actualizado protocolos de cuidados y registros correspondientes, también se han evaluado de forma sistemática los resultados de proceso y de salud de los pacientes. También se han difundido activamente los principales logros del programa. Conclusiones: Los candidatos a Centros Comprometidos con la Excelencia en Cuidados® están realizando un gran esfuerzo y los resultados empiezan a mostrar que son positivos, con una creciente cultura de cuidados basados en la evidencia, y el impulso de la investigación y el inicio de un trabajo colaborativo en red. [Albornos-Muñoz L, González-María E, Moreno-Casbas T. Implantación de guías de buenas prácticas en España. Programa de

  17. A new tropical Oligocene dolphin from Montañita/Olón, Santa Elena, Ecuador.

    Science.gov (United States)

    Tanaka, Yoshihiro; Abella, Juan; Aguirre-Fernández, Gabriel; Gregori, Maria; Fordyce, R Ewan

    2017-01-01

    A new small probable Oligocene dolphin from Ecuador represents a new genus and species, Urkudelphis chawpipacha. The new taxon is known from a single juvenile skull and earbones; it differs from other archaic dolphins in features including widely exposed frontals at the vertex, a dorsally wide open vomer at the mesorostral groove, and a strongly projected and pointed lateral tuberosity of the periotic. Phylogenetic analysis places it toward the base of the largely-extinct clade Platanistoidea. The fossil is one of a few records of tropical fossil dolphins.

  18. ALUMNO: Flores Gómez Elena Beatriz Psycometric properties of the Modified Tonic Inmobility Scale

    OpenAIRE

    Bados, Arturo; Peró, Maribel

    2018-01-01

    La Escala de Inmovilidad Tónica ha sido estudiada sólo en víc-timas de abusos y/o agresiones sexuales, pero la inmovilidad tónica (IT) puede darse ante otros eventos traumáticos. En consecuencia, nos propu-simos modificar la escala con este fin y estudiar su estructura factorial y otras propiedades psicométricas (consistencia interna y validez convergente, divergente y discriminante) en 392 universitarios, la mayoría de los cuales había padecido uno o más eventos traumáticos de distintos tipo...

  19. El lenguaje figurativo de antes y de ahora en la provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Mónica Tomalá

    2014-12-01

    appropriate, by the computer, since all written work usually is printed . And if it comes to writing standards, the computer does its job, he helps the person who writes placing automatically the respective punctuation, intonation and possibly to the auxiliary, on the other hand, corrects him without asking, the structure of each word.

  20. ANÁLISIS INTERNO DEL SECTOR TURÍSTICO DE DOS MANGAS, PROVINCIA DE SANTA ELENA

    Directory of Open Access Journals (Sweden)

    Jhony Yumisaca Tuquinga

    2017-01-01

    analyzes  the  empirical  raid  Dos  Mangas  in  this  activity  and  functionality  of  its  components  supply, demand,  competition  and  trends  that  revolve  around  these.  The  study  revolved  around  the  empirical method and systemic methodology that considers the tourism sector as a multiplier subsystem in the rest of the  part  economic  system,  for  which  on  the  one  hand  demand  is  analyzed  in  its  components  number  of tourists,  daily  expenditure  and  the  average  stay  and,  moreover  considering  the  offer  to  its  structure, management and its variable employment generated in the local tourism productive; resulted in a diagnosis of  tourism  system  of  the  commune  Dos  Mangas,  from  which  it  may  propose  strategies  for  tourism development in this destination offers.

  1. A new tropical Oligocene dolphin from Montañita/Olón, Santa Elena, Ecuador

    Science.gov (United States)

    Abella, Juan; Aguirre-Fernández, Gabriel; Gregori, Maria; Fordyce, R. Ewan

    2017-01-01

    A new small probable Oligocene dolphin from Ecuador represents a new genus and species, Urkudelphis chawpipacha. The new taxon is known from a single juvenile skull and earbones; it differs from other archaic dolphins in features including widely exposed frontals at the vertex, a dorsally wide open vomer at the mesorostral groove, and a strongly projected and pointed lateral tuberosity of the periotic. Phylogenetic analysis places it toward the base of the largely-extinct clade Platanistoidea. The fossil is one of a few records of tropical fossil dolphins. PMID:29261688

  2. Images of women in advertising : dynamics and consumer perceptions / Elena Pruvli

    Index Scriptorium Estoniae

    Pruvli, Elena

    2003-01-01

    Kaanel ajak. ilmumisaeg 2002/2003. Ülevaade naise imago kujutamisest reklaamis, erinevaid naisetüüpe esitavate reklaamide vastuvõtmisest ja mõjudest hoiakutele ning käitumisele EBS-is läbiviidud uuringu põhjal

  3. Naistest ja solidaarsusest / Marge Monko, Liina Siib ; intervjueerinud Elena Šmakova

    Index Scriptorium Estoniae

    Monko, Marge, 1976-

    2009-01-01

    Töötavate naiste õigustest, töökeskkonnast ja sõltumisest tööhõivepoliitikast. Näitused Tallinnas: Marge Monko isikunäitus "Leib ja lilled" Draakoni Galeriis 8.-21. märtsini, Liina Siibi fotonäitus "Naine võtab vähe ruumi" Hobusepea Galeriis 18.-30. märtsini

  4. Meistri kutsumine / Taavi Talve, Indrek Köster ; intervjueerinud Elena Šmakova

    Index Scriptorium Estoniae

    Talve, Taavi

    2009-01-01

    Loomingulise ühenduse Johnson ja Johnson - Taavi Talve, Indrek Köster - näitus "Meistri kutsumine" Hobusepea Galeriis 27. aprillini. Autorid 2006. aastal alustatud Paldiski linnaruumi ja selle elanikke kaasavast projektist, mille lõppeesmärk on luua Paldiskisse Amandus Adamsoni skulptuur. Linnaelanike lemmikuks osutus teos "Laeva viimne ohe", mille savist suurenduse modelleerib Mare Mikof

  5. Muid võimalusi ei ole! / Kristina Norman, Marco Laimre ; intervjueerinud Elena Šmakova

    Index Scriptorium Estoniae

    Norman, Kristina, 1979-

    2009-01-01

    53. Veneetsia biennaalil "Making Worlds" ("Konstrueerides maailmu") Eestit esindavast Kristina Normani Tõnismäe pronkssõduri monumenti käsitlevast kunstiprojektist "After-War" ("Järelsõda"). Projekti kuraator Marco Laimre. Eesti ekspositsioon on avatud Palazzo Malipieros 6. juunist 22. novembrini. Biennaali nõukogu otsustas anda suured Kuldsed Lõvid elutöö eest Yoko Onole ja John Baldessarile

  6. La herencia cultural en Santa Elena: etnicidad y memoria oral en La Libertad (Ecuador

    Directory of Open Access Journals (Sweden)

    Susana Anda

    2015-10-01

    This paper illustrates in a general and schematic way the cultural manifestations related to ethnicity and oral memory of the people in La Libertad in 2014. It does no intend to show a complete and detailed analysis of these aspects, however it seeks to highlight important cultural dynamics of the region. The research focused on ethnical construction and in the registration of cultural data of intangible heritage, understanding it as the practices, representations, expressions, knowledge and techniques that are transmitted from generation to generation among groups and individuals. The overall objective is to present some records of oral memory that conform part of the local intangible heritage, prioritizing a wide range of views on memory and social praxis of minorities, which often are left voiceless in the official history and without evidence in theoretical writing. To do this, an ethnographic study was necessary. The local testimonies provided key information for the reconstruction of their social, cultural, economic and ecological history. This research rescues cultural dynamics that are relevant in the construction of their social identity. Therefore, the registration of intangible heritage in La Libertad is not only the key for cultural safeguard, it also is a tool to build the basis for diagnostic, research and planning safeguard lines, providing transmission, recovery and dissemination of cultural knowledge in the context of constructing a plurinational and intercultural State.

  7. Informe Científico de Investigador: Vela, María Elena (2012-2013)

    OpenAIRE

    Vela, María Elena

    2013-01-01

    Se avanzó en la caracterización y estudio de las propiedades fisicoquímicas de monocapas autoensambladas (SAMs) de alcanotioles simples y funcionalizados como también en su empleo como plataformas de construcción en la nanoescala. Se analizaron las condiciones de estabilidad de las SAMs en sustratos planos y nanoestructurados de Au. Se estudiaron las propiedades de cianinas tioladas autoensambladas sobre superficies lisas y nanopartículas de oro con posibles aplicaciones en el campo de los bi...

  8. Ciclos represivos y conflictos de identidad en las crónicas de Elena Poniatowska

    OpenAIRE

    Estrada, Oswaldo

    2008-01-01

    Relaciones entre la crónica de Indias y el nuevo discurso testimonial, desde la perspectiva del encuentro cultural. Enfrentamiento entre las diferentes culturas, cuyos signos de identidad plantea la escritora en obras como Fuerte es el silencio, Nada, nadie las voces del Temblor, o Amanecer en el Zócalo. The realtionships between the crónica de Indias and the new testimonial discourse from a cross cultural perspective. These cultural clashes appear in the works Fuerte es el silencio, Nada,...

  9. Double life of centrioles: CP110 in the spotlight.

    Science.gov (United States)

    Bettencourt-Dias, Mónica; Carvalho-Santos, Zita

    2008-01-01

    Centrioles lead an important double life: they can give rise to the centrosome or convert to basal bodies and template cilia. Little is known about the control of centriole fate. Spektor and colleagues have now identified a centriolar complex, composed of CP110 and CEP97, which inhibits centriole to basal body conversion, preventing cilia formation. This work paves the way to understanding centriole and cilia biogenesis, which are two processes misregulated in human diseases, such as cancer and polycystic kidney disease.

  10. Grantee Spotlight: Dr. Kolawole Okuyemi - Improving Cervical Cancer Screening Attitudes

    Science.gov (United States)

    Dr. Kolawole Okuyumi is studying cervical cancer screening attitudes and behaviors of African immigrants and refugees (Ethiopians, Nigerians, and Somalis) in Minnesota, and introducing “cancer” and “cervix” to their everyday vocabulary.

  11. Grantee Spotlight: Bill Nelson, M.D., Ph.D.

    Science.gov (United States)

    Dr. William (Bill) Nelson is playing an integral role in advancing our understanding of cancer health disparities and helping to foster the interests of young students from underrepresented backgrounds in cancer/cancer health disparities research.

  12. PARTICLE FACTORIES: Tau-charm in the spotlight

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1991-07-15

    Following earlier workshops in Stanford (1989) and in Orsay (1990), some hundred physicists from Europe and the United States met from 29 April to 2 May in Seville, Spain, to consolidate plans for a Tau-Charm Factory.

  13. Aging, metabolism and stem cells: Spotlight on muscle stem cells.

    Science.gov (United States)

    García-Prat, Laura; Muñoz-Cánoves, Pura

    2017-04-15

    All tissues and organs undergo a progressive regenerative decline as they age. This decline has been mainly attributed to loss of stem cell number and/or function, and both stem cell-intrinsic changes and alterations in local niches and/or systemic environment over time are known to contribute to the stem cell aging phenotype. Advancing in the molecular understanding of the deterioration of stem cell cells with aging is key for targeting the specific causes of tissue regenerative dysfunction at advanced stages of life. Here, we revise exciting recent findings on why stem cells age and the consequences on tissue regeneration, with a special focus on regeneration of skeletal muscle. We also highlight newly identified common molecular pathways affecting diverse types of aging stem cells, such as altered proteostasis, metabolism, or senescence entry, and discuss the questions raised by these findings. Finally, we comment on emerging stem cell rejuvenation strategies, principally emanating from studies on muscle stem cells, which will surely burst tissue regeneration research for future benefit of the increasing human aging population. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  14. Spotlight on Brain Tumors: Do You Know the Symptoms?

    Science.gov (United States)

    ... of the tumor. Treatment can involve surgery, radiation (beams of high energy rays aimed at the tumor), ... in speech, vision, or hearing Problems balancing or walking Changes in your mood, personality, or ability to ...

  15. Bridge scour conference shares knowledge and innovations : Tech Transfer Spotlight

    Science.gov (United States)

    2018-01-01

    The National Cooperative Highway Research Programs Domestic Scan (NCHRP Project 20-68A) on bridge scour risk management brought more than 30 national bridge scour experts together for a week in July 2016 to examine ways to prevent and remediate br...

  16. Epigenetics: spotlight on type 2 diabetes and obesity.

    Science.gov (United States)

    Desiderio, A; Spinelli, R; Ciccarelli, M; Nigro, C; Miele, C; Beguinot, F; Raciti, G A

    2016-10-01

    Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research areas in biomedicine as changes in the epigenome are involved in many biological processes, impact on the risk for several complex diseases including diabetes and may explain susceptibility. In this review, we focus on the role of DNA methylation in contributing to the risk of T2D and obesity.

  17. CERN in the spotlight at the Geneva Festival

    CERN Document Server

    2004-01-01

    CERN will be the guest of honour at the Geneva Festival, which takes place from 29 July to 8 August. The Organization will be involved in two big events: the curtain-raising firework display and the end-of-festival concert. Come and see the creation of the Universe... acted out by fireworks! CERN, celebrating its 50th anniversary, will raise the curtain on the annual Geneva Festival (Fêtes de Genève) on Friday 30 July at 10.15 p.m. with a pyrotechnical and musical extravaganza. The display will be accompanied by a narration explaining the different stages of creation, written by CERN physicist Rolf Landua. Pyro-musical design is by Catherine Walder, overall firework design by René Gousset and pyrotechnical design by Pierre-Alain Beretta (Pyrostars). For further information see: www.cern.ch/cern50/events/Fireworks/Fireworks-en.html. At the end of the Festival, the CERN choir, itself celebrating its thirtieth year, joins forces with the Annecy choir Pro Musica to give a special performance of Jo...

  18. Fifty years of CERN history in the spotlight

    CERN Document Server

    2004-01-01

    The programme of events for CERN's Golden Jubilee year was officially unveiled at a press conference on 8 March. The first of these events took place the following day, when the Swiss commemorative postage stamp issued in the Laboratory's honour went on sale in post offices throughout Switzerland.

  19. Voicing Others' Voices: Spotlighting the Researcher as Narrator

    Science.gov (United States)

    O'Sullivan, Dan

    2015-01-01

    As qualitative research undertakings are not independent of the researcher, the "indissoluble interrelationship between interpreter and interpretation" (Thomas & James, 2006, p. 782) renders it necessary for researchers to understand that their text is a representation, a version of the truth that is the product of writerly choices,…

  20. In the spotlight: informal care in the Netherlands

    NARCIS (Netherlands)

    Debbie Oudijk; Alice de Boer; Isolde Woittiez; Joost Timmermans & Mirjam de Klerk

    2010-01-01

    Informal care is care that is provided by someone who is close to the care-receiver. It may include: • care given by members of the care-receiver's household, relatives, friends, acquaintances, colleagues or neighbours which stems from a relationship between the care-giver and care-receiver;

  1. The 2015 Five-yearly review: diversity in the spotlight

    CERN Multimedia

    Staff Association

    2014-01-01

    Introduction As mentioned in Echo 201, with the Council Decision of last June the CERN 2015 five-yearly review has formally begun. Following the procedure defined in Annex A1 of the Staff Rules and Regulations CERN will thus review its financial and social conditions that should enable it to recruit from all its Member States, and retain, staff of the highest competence and integrity necessary to perform its mission. In addition, these conditions should increase the attractiveness of CERN in all Member States and motivate staff of all ages and all occupations throughout their careers. Annex A1 stipulates that a five-yearly review must include basic salaries (stipends for Fellows and subsistence allowances for associated members of the personnel) and, optionally, may include any other financial or social conditions. For this optional part of the 2015 exercise, the CERN career structure and measures to improve diversity were chosen. Towards a better diversity policy The analysis of the 2013 Staff Associat...

  2. Spotlight on dream recall: the ages of dreams.

    Science.gov (United States)

    Mangiaruga, Anastasia; Scarpelli, Serena; Bartolacci, Chiara; De Gennaro, Luigi

    2018-01-01

    Brain and sleep maturation covary across different stages of life. At the same time, dream generation and dream recall are intrinsically dependent on the development of neural systems. The aim of this paper is to review the existing studies about dreaming in infancy, adulthood, and the elderly stage of life, assessing whether dream mentation may reflect changes of the underlying cerebral activity and cognitive processes. It should be mentioned that some evidence from childhood investigations, albeit still weak and contrasting, revealed a certain correlation between cognitive skills and specific features of dream reports. In this respect, infantile amnesia, confabulatory reports, dream-reality discerning, and limitation in language production and emotional comprehension should be considered as important confounding factors. Differently, growing evidence in adults suggests that the neurophysiological mechanisms underlying the encoding and retrieval of episodic memories may remain the same across different states of consciousness. More directly, some studies on adults point to shared neural mechanisms between waking cognition and corresponding dream features. A general decline in the dream recall frequency is commonly reported in the elderly, and it is explained in terms of a diminished interest in dreaming and in its emotional salience. Although empirical evidence is not yet available, an alternative hypothesis associates this reduction to an age-related cognitive decline. The state of the art of the existing knowledge is partially due to the variety of methods used to investigate dream experience. Very few studies in elderly and no investigations in childhood have been performed to understand whether dream recall is related to specific electrophysiological pattern at different ages. Most of all, the lack of longitudinal psychophysiological studies seems to be the main issue. As a main message, we suggest that future longitudinal studies should collect dream reports upon awakening from different sleep states and include neurobiological measures with cognitive performances.

  3. Fisheries management worldwide has been under the spotlight in ...

    African Journals Online (AJOL)

    denise

    lighted by several studies (Bennett et al. 1994 ... Catch per unit effort data suggest that the species were between five and 21 times more abundant in the TNP. ... (cpue) data collected during the tag and release pro- ... when handling the fish, following the methods de- ... mass using the relationships provided by Bennett and.

  4. Research Spotlight: Climate commitment in an uncertain world

    Science.gov (United States)

    Tretkoff, Ernie

    2011-02-01

    Even if humans immediately ceased emitting carbon dioxide (CO2) and other greenhouse gases, the planet would continue to warm, mainly due to thermal inertia of the world's oceans. This “climate commitment” has been of interest recently for both science and policy because it provides a measure of the minimum climate change the planet will face given human activity that has already occurred. Several studies have looked at what would happen if human emission of CO2 were halted, but these studies have overlooked the role of aerosols and non-CO2 greenhouse gases such as methane and nitrous oxide, which Armour and Roe include in a new study. If human emission stopped, atmospheric aerosols, which cool the planet by blocking light from the surface, would fall to preindustrial levels within weeks. However, non-CO2 greenhouse gases would remain in the atmosphere for decades to centuries, and elevated levels of CO2 would persist for millennia. (Geophysical Research Letters, doi:10.1029/2010GL045850, 2011)

  5. Spotlight on ixazomib: potential in the treatment of multiple myeloma

    Directory of Open Access Journals (Sweden)

    Muz B

    2016-01-01

    Full Text Available Barbara Muz,1 Rachel Nicole Ghazarian,1,2 Monica Ou,1,3 Micah John Luderer,1 Hubert Daniel Kusdono,1,2 Abdel Kareem Azab1 1Department of Radiation Oncology, Cancer Biology Division, Washington University in St Louis School of Medicine, 2Department of Pharmaceutical and Administrative Sciences, St Louis College of Pharmacy, 3Department of Biology, St Louis University, St Louis, MO, USA Abstract: Despite the significant therapeutic advances achieved with proteasome inhibitors (PIs such as bortezomib and carfilzomib in prolonging the survival of patients with multiple myeloma, the development of drug resistance, peripheral neuropathy, and pharmacokinetic limitations continue to pose major challenges when using these compounds. Ixazomib is a second-generation PI with improved activity over other PIs. Unlike bortezomib and carfilzomib, which are administered by injection, ixazomib is the first oral PI approved by US Food and Drug Administration. This review discusses the biochemical properties, mechanisms of action, preclinical efficacy, and clinical trial results leading to the US Food and Drug Administration approval of ixazomib. Keywords: proteasome inhibitor, oral administration, biological mechanism, clinical trials

  6. Research Spotlight: Satellites monitor air pollutant emissions in China

    Science.gov (United States)

    Tretkoff, Ernie

    A new satellite study verifies that Chinese emission control efforts did reduce power plant emissions of sulfur dioxide (SO2), a harmful gas that causes acid rain and can form sulfate aerosols; these aerosols play an important role in the climate system by affecting clouds and precipitation patterns and altering the amount of sunlight that is reflected away from Earth.

  7. Gamma rays spotlight a dark horse for dark matter

    CERN Multimedia

    Seife, C

    2004-01-01

    "Do mysterious gamma rays emanating from the center of the galaxy hold the secret to the missing matter in the universe? A team of physicists suggests that they might. The controversial finding also shows how little is known about most of the mass in the cosmos"(1/2 page)

  8. PARTICLE FACTORIES: Tau-charm in the spotlight

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Following earlier workshops in Stanford (1989) and in Orsay (1990), some hundred physicists from Europe and the United States met from 29 April to 2 May in Seville, Spain, to consolidate plans for a Tau-Charm Factory

  9. ACHP | News | ACHP Issue Spotlight: Transmission Lines in the West

    Science.gov (United States)

    experience, creativity, and leadership when they were greatly needed. Donaldson was accompanied by his wife Leadership Chairman Wayne Donaldson Receives AIA Award for Leadership ACHP Chairman Milford Wayne Donaldson recognition of leadership provided by Milford Wayne Donaldson, FAIA, in historic preservation at the national

  10. Spotlight on dream recall: the ages of dreams

    Directory of Open Access Journals (Sweden)

    Mangiaruga A

    2018-01-01

    Full Text Available Anastasia Mangiaruga, Serena Scarpelli, Chiara Bartolacci, Luigi De Gennaro Department of Psychology, University of Rome “Sapienza”, Rome, Italy Abstract: Brain and sleep maturation covary across different stages of life. At the same time, dream generation and dream recall are intrinsically dependent on the development of neural systems. The aim of this paper is to review the existing studies about dreaming in infancy, adulthood, and the elderly stage of life, assessing whether dream mentation may reflect changes of the underlying cerebral activity and cognitive processes. It should be mentioned that some evidence from childhood investigations, albeit still weak and contrasting, revealed a certain correlation between cognitive skills and specific features of dream reports. In this respect, infantile amnesia, confabulatory reports, dream-reality discerning, and limitation in language production and emotional comprehension should be considered as important confounding factors. Differently, growing evidence in adults suggests that the neurophysiological mechanisms underlying the encoding and retrieval of episodic memories may remain the same across different states of consciousness. More directly, some studies on adults point to shared neural mechanisms between waking cognition and corresponding dream features. A general decline in the dream recall frequency is commonly reported in the elderly, and it is explained in terms of a diminished interest in dreaming and in its emotional salience. Although empirical evidence is not yet available, an alternative hypothesis associates this reduction to an age-related cognitive decline. The state of the art of the existing knowledge is partially due to the variety of methods used to investigate dream experience. Very few studies in elderly and no investigations in childhood have been performed to understand whether dream recall is related to specific electrophysiological pattern at different ages. Most of all, the lack of longitudinal psychophysiological studies seems to be the main issue. As a main message, we suggest that future longitudinal studies should collect dream reports upon awakening from different sleep states and include neurobiological measures with cognitive performances. Keywords: dreaming, sleep mentation, development, sleep, continuity hypothesis, aging

  11. American high school students shine a spotlight on CERN

    CERN Multimedia

    2008-01-01

    Between 2 and 7 April eighteen American high school students were let loose at CERN armed with video cameras. Their mission? To take on the role of broadcast journalists and inspire their peers across the US with short documentaries and blogs illuminating the work happening at the world’s most powerful particle accelerator. Members of the teams of budding physicists and broadcast journalists pose in front of the ATLAS detector.Following in the footsteps of professional journalists around the world, six teams of American high school students recently travelled to CERN to experience the increasing excitement in the run-up to the switch-on of the LHC. The six teams are from five states across the US and were the winners of a competition sponsored and funded by the US Department of Energy’s Office of Science and the National Science Foundation. Each team consists of three students plus a teacher, who combine their knowledge of ph...

  12. Monitoring highway assets using remote sensing technology : research spotlight.

    Science.gov (United States)

    2014-04-01

    Collecting inventory data about roadway assets is a critical part of : MDOTs asset management efforts, which help the department operate, : maintain and upgrade these assets cost-effectively. Federal law requires : that states develop a risk-based...

  13. Spotlight on topographical pressure pain sensitivity maps: a review

    Directory of Open Access Journals (Sweden)

    Alburquerque-Sendín F

    2018-01-01

    Full Text Available Francisco Alburquerque-Sendín,1 Pascal Madeleine,2 César Fernández-de-las-Peñas,3 Paula Rezende Camargo,4 Tania Fátima Salvini4 1Department of Socio-Sanitary Sciences, Radiology and Physical Medicine, Universidad de Córdoba, Córdoba, Spain; 2Physical Activity and Human Performance Group, SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark; 3Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos, Madrid, Spain; 4Department of Physical Therapy, Federal University of São Carlos, São Carlos, SP, Brazil Abstract: Mechanical hyperalgesia defined as decreased pressure pain thresholds (PPTs is commonly associated with pain. In this narrative review, we report the current state of the art within topographical pressure sensitivity maps. Such maps are based on multiple PPT assessments. The PPTs are assessed by an a priori defined grid with special focus on both spatial and temporal summation issues. The grid covers the muscle or the body region of interest using absolute or relative values determined from anatomical landmarks or anthropometric values. The collected PPTs are interpolated by Shepard or Franke and Nielson interpolation methods to create topographical pressure sensitivity maps. This new imaging technique has proven to be valuable in various disciplines including exercise physiology, neurology, physical therapy, occupational medicine, oncology, orthopedics, and sport sciences. The reviewed papers have targeted different body regions like the scalp, low back, neck–shoulder, and upper and lower extremities. The maps have delineated spatial heterogeneity in the pressure pain sensitivity underlining the different extents of pressure pain hyperalgesia in both experimentally induced and disease-associated pain conditions. Furthermore, various intervention studies have proven the utility of topographical pressure pain sensitivity maps. Topographical pressure pain sensitivity maps have contributed to revealing the efficacy of therapeutic, ergonomic, or training interventions that aim at reducing pain. Keywords: pressure pain, topographical, muscle, musculo-tendinous, hyperalgesia

  14. Spotlight back on LHW with Yucca Mountain on Trump's horizon

    International Nuclear Information System (INIS)

    Shepherd, John

    2017-01-01

    After years of argument and delay could the US be edging closer to resurrecting proposals to build a national repository for high level nuclear waste (HLW) at Yucca Mountain in Nevada? The federal government has looked at the site with a view to establishing a repository since the 1970s. However, after pouring billions of dollars into projects and studies over the decades, the project remained bogged down in legal battles and opposition from politicians and pressure groups. Now, the US Nuclear Regulatory Commission (NRC) said it had directed its staff to use the equivalent of about EUR 95,000 from the national Nuclear Waste Fund on ''information-gathering activities'' that could pave the way for resuming a licensing review of Yucca Mountain as a potential deep geologic repository (DGR).

  15. Spotlight on Ethics: Institutional Review Boards as Systemic Bullies

    Science.gov (United States)

    Carr, Caleb T.

    2015-01-01

    Bullying, often considered an interpersonal or intergroup behaviour, has not been explored as an unintended artefact of organisational structure. Institutional review boards (IRBs), the 'human research ethics committees' at US universities, help oversee the protection of human research subjects, particularly in the social sciences within…

  16. Zenodo in the Spotlight of Traditional and New Metrics

    Directory of Open Access Journals (Sweden)

    Isabella Peters

    2017-12-01

    Full Text Available In this case study, we aim to explore the characteristics and the reception of files uploaded to Zenodo, and the role the repository plays itself in generating usage. To this end, we first apply descriptive statistics on Zenodo’s full set of data record metadata with digital object identifiers (DOIs until and including January 2017 (n = 141,777 records. Second, we estimate the coverage of Zenodo datasets in the Data Citation Index as well as of Zenodo journal articles in the Science Citation Index, Social Science Citation Index, and Arts and Humanities Citation Index, Zenodo books and book chapters in the Book Citation Index, and Zenodo conference papers in the Proceedings Citation Index, and analyze their citedness according to the different data record types in Zenodo (e.g., journal article, dataset, book, or conference paper. Third, we provide a bibliometric analysis of Zenodo records by using different metrics for citedness, including citation, usage, and altmetrics. Altmetrics data are gathered from two of the most popular tools for altmetric analyses, PlumX and Altmetric.com, and we compare the results. Moreover, we study how open access and DOIs provided by Zenodo influence the impact of Zenodo data records and we find a tendency toward a positive relationship between permissive access rights and altmetrics in certain data records.

  17. In the spotlight: New hydro development in North America

    International Nuclear Information System (INIS)

    Barnes, M.J.

    1993-01-01

    1992 was a year of progress for many segments of the hydropower industry as developers worked to bring new projects on line. This industry overview features several of these projects and offers a preview of 1993 activity. The only operating privately owned hydroelectric project in Texas. The largest hydro plant in the province of Manitoba. The world's largest submersible hydroturbine-generator. These projects and others-completed and placed in service in 1992-can claim a special place in the history books. For each of the 31 hydro projects in North America that began operating in 1992, there's a unique story to tell. Each called upon the time, talent, commitment, ingenuity, and perseverance of those involved in their development. In aggregate, these projects contribute nearly 3,800 MW of clean, renewable electrical capacity that can be used efficiently and cost-effectively to help meet the power demands of customers in the US and Canada. Utilities, state agencies, municipalities, and independent power developers played roles in developing new hydro in 1992. We offer a sampling of their work to illustrate progress made in the past year

  18. Grantee Spotlight: Elisa Rodriguez, Ph.D., M.S.

    Science.gov (United States)

    Dr. Elisa M. Rodriguez tests the feasibility of community-based participatory research approaches to engaging Hispanics, African Americans, and the medically underserved in the Buffalo, NY area in biospecimen donation for cancer research.

  19. Software offers transparent, straightforward assessment of pavement additives : research spotlight.

    Science.gov (United States)

    2015-04-01

    Adding new materials to pavement layers is a proven technique to : improve performance. Many types of additivesfrom engineered : polymers and acids to recycled pavement, crumb rubber, shingles : and glasshave been used to help construct better ...

  20. Program Spotlight: National Outreach Network's Community Health Educators

    Science.gov (United States)

    National Outreach Network of Community Health Educators located at Community Network Program Centers, Partnerships to Advance Cancer Health Equity, and NCI-designated cancer centers help patients and their families receive survivorship support.

  1. Spotlight on middle childhood: Rejuvenating the 'forgotten years'.

    Science.gov (United States)

    Mah, V Kandice; Ford-Jones, E Lee

    2012-02-01

    Middle childhood, from six to 12 years of age, is often known as the 'forgotten years' of development because most research is focused on early childhood development or adolescent growth. However, middle childhood is rich in potential for cognitive, social, emotional and physical advancements. During this period, the brain is actively undergoing synaptic pruning and, as such, is constantly becoming more refined, a process that is heavily dependent on a child's environment. This discovery opens the door to optimizing the experiences a child needs to provide themselves with a strong foundation for adulthood. The present article reviews the neurological changes that occur in middle childhood, their impact on overall development and how to implement this knowledge to augment a child's capabilities.

  2. Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis

    Science.gov (United States)

    Mora, Ana L.; Rojas, Mauricio

    2017-01-01

    Idiopathic pulmonary fibrosis (IPF) is a chronic age-related lung disease with high mortality that is characterized by abnormal scarring of the lung parenchyma. There has been a recent attempt to define the age-associated changes predisposing individuals to develop IPF. Age-related perturbations that are increasingly found in epithelial cells and fibroblasts from IPF lungs compared with age-matched cells from normal lungs include defective autophagy, telomere attrition, altered proteostasis, and cell senescence. These divergent processes seem to converge in mitochondrial dysfunction and metabolic distress, which potentiate maladaptation to stress and susceptibility to age-related diseases such as IPF. Therapeutic approaches that target aging processes may be beneficial for halting the progression of disease and improving quality of life in IPF patients. PMID:28145905

  3. An inverse method for color uniformity in white LED spotlights

    NARCIS (Netherlands)

    Prins, C.R.; Thije Boonkkamp, ten J.H.M.; Tukker, T.W.; IJzerman, W.L.

    2013-01-01

    Color over Angle (CoA) variation in the light output of white phosphor-converted LEDs is a common problem in LED lighting technology. In this article we propose an inverse method to design an optical element that eliminates the color variation for a point light source. The method in this article is

  4. An inverse method for color uniformity in white LED spotlights

    NARCIS (Netherlands)

    Prins, C.R.; Thije Boonkkamp, ten J.H.M.; Tukker, T.W.; IJzerman, W.L.

    2014-01-01

    Color over Angle (CoA) variation in the light output of white phosphor-converted LEDs is a common problem in LED lighting technology. In this article we propose an inverse method to design an optical element that eliminates the color variation for a point light source. The method in this article is

  5. A THEORETICAL SPOTLIGHT OVER THE ROMANIAN AGRICULTURAL PRODUCTS

    Directory of Open Access Journals (Sweden)

    Tarcza Teodora

    2012-07-01

    Full Text Available This paper aims at identifying and classifying new types of agricultural products, especially in Romania, but not only. As we well know, all the countries all over the world have their own history, traditions, economic structure, and a certain type of agriculture, adapted to their soil, climate, and nevertheless to theirs people needs. So, we know that certain countries used to cultivate certain agricultural products, while others are wellknown for others. Usually, we associate Spain with great wines, Belgium with delicious chocolate, Turkey with coffee, India with rice, Romania with grain, Russia with cereals, SUA – tobacco, etc.\\r\

  6. Cosmology and Prehistory: Imagination on the Rise. Spotlight: Montessori Potpourri.

    Science.gov (United States)

    Hallenberg, Harvey

    2001-01-01

    Presents the Maori cosmological perspective and the modern theory of evolution. Explains how these two creation stories can coexist. Discusses life on earth during its first 3 billion years, including concepts of singularity, Big Bang, time, space, matter, gravity, stars, planets, seas, and life. (DLH)

  7. New Standards Put the Spotlight on Professional Learning

    Science.gov (United States)

    Mizell, Hayes; Hord, Shirley; Killion, Joellen; Hirsh, Stephanie

    2011-01-01

    Learning Forward introduces new Standards for Professional Learning. This is the third iteration of standards outlining the characteristics of professional learning that lead to effective teaching practices, supportive leadership, and improved student results. The standards are not a prescription for how education leaders and public officials…

  8. Money, money, money [spotlight on financial activity in India

    International Nuclear Information System (INIS)

    Sahai, I.M.

    1998-01-01

    India, with its long history of and vast potential for hydroelectric power, seems set to prioritise this form of power generation, by encouraging private investment in the hydroelectric power through financial incentives. The main reason for the lack of development of the country''s hydro potential is a paucity of financial resources and consequent tardy investment in the hydropower sector, because of the slow rate of return to investors. Government pressure and an expected announcement about policy on hydropower has led to new initiatives to fund new hydroelectric power plants and refurbish the older ones. (UK)

  9. Isoprenoid biosynthesis in eukaryotic phototrophs: A spotlight on algae

    Energy Technology Data Exchange (ETDEWEB)

    Lohr M.; Schwender J.; Polle, J. E. W.

    2012-04-01

    Isoprenoids are one of the largest groups of natural compounds and have a variety of important functions in the primary metabolism of land plants and algae. In recent years, our understanding of the numerous facets of isoprenoid metabolism in land plants has been rapidly increasing, while knowledge on the metabolic network of isoprenoids in algae still lags behind. Here, current views on the biochemistry and genetics of the core isoprenoid metabolism in land plants and in the major algal phyla are compared and some of the most pressing open questions are highlighted. Based on the different evolutionary histories of the various groups of eukaryotic phototrophs, we discuss the distribution and regulation of the mevalonate (MVA) and the methylerythritol phosphate (MEP) pathways in land plants and algae and the potential consequences of the loss of the MVA pathway in groups such as the green algae. For the prenyltransferases, serving as gatekeepers to the various branches of terpenoid biosynthesis in land plants and algae, we explore the minimal inventory necessary for the formation of primary isoprenoids and present a preliminary analysis of their occurrence and phylogeny in algae with primary and secondary plastids. The review concludes with some perspectives on genetic engineering of the isoprenoid metabolism in algae.

  10. Spotlight on the Diagnosis of Acute Promyelocytic Leukemia (AML ...

    African Journals Online (AJOL)

    QR-RT-PCR demonstrated bcr1 positivity in the 4 patients diagnosed by Karyotyping with t (15;17) and in the 8 patients can not diagnosed by Cytogenetic methods. Conclusion: Despite the fact that cytogenetics permit the identification of many chromosomal changes within a sample, FISH analysis is more sensitive when ...

  11. The BRiCS in the spotlight: a research agenda

    OpenAIRE

    SCAFFARDI LUCIA; FEDERICO VERONICA

    2014-01-01

    On November 6–7, 2014, the University of Parma (Italy) hosted a profound two-day discussion on the BRICS, i.e. Brazil, Russia, India, China and South Africa, a relatively new actor in the international arena, gathering the most innovative research and the leading experts and scholars.

  12. Abuses of sugar market in Latvia, Estonia under spotlight

    Index Scriptorium Estoniae

    2004-01-01

    Läti konkurentsiamet sulges hindade mõjutamise tõttu riigi suuruselt teise suhkruvabriku. Eestit trahvitakse suhkru varumise eest enne Euroopa Liitu astumist. Leedus on aga suhkru tarbimine langenud

  13. Research Spotlight: The next big thing is actually small.

    Science.gov (United States)

    Garcia, Carlos D

    2012-07-01

    Recent developments in materials, surface modifications, separation schemes, detection systems and associated instrumentation have allowed significant advances in the performance of lab-on-a-chip devices. These devices, also referred to as micro total analysis systems (µTAS), offer great versatility, high throughput, short analysis time, low cost and, more importantly, performance that is comparable to standard bench-top instrumentation. To date, µTAS have demonstrated advantages in a significant number of fields including biochemical, pharmaceutical, military and environmental. Perhaps most importantly, µTAS represent excellent platforms to introduce students to microfabrication and nanotechnology, bridging chemistry with other fields, such as engineering and biology, enabling the integration of various skills and curricular concepts. Considering the advantages of the technology and the potential impact to society, our research program aims to address the need for simpler, more affordable, faster and portable devices to measure biologically active compounds. Specifically, the program is focused on the development and characterization of a series of novel strategies towards the realization of integrated microanalytical devices. One key aspect of our research projects is that the developed analytical strategies must be compatible with each other; therefore, enabling their use in integrated devices. The program combines spectroscopy, surface chemistry, capillary electrophoresis, electrochemical detection and nanomaterials. This article discusses some of the most recent results obtained in two main areas of emphasis: capillary electrophoresis, microchip-capillary electrophoresis, electrochemical detection and interaction of proteins with nanomaterials.

  14. Nutrition in the spotlight: metabolic effects of environmental light

    NARCIS (Netherlands)

    Versteeg, Ruth I.; Stenvers, Dirk J.; Kalsbeek, Andries; Bisschop, Peter H.; Serlie, Mireille J.; la Fleur, Susanne E.

    2016-01-01

    Use of artificial light resulted in relative independence from the natural light-dark (LD) cycle, allowing human subjects to shift the timing of food intake and work to convenient times. However, the increase in artificial light exposure parallels the increase in obesity prevalence. Light is the

  15. Nutrition in the spotlight metabolic effects of environmental light

    NARCIS (Netherlands)

    Versteeg, Ruth I; Stenvers, Dirk J; Kalsbeek, A.; Bisschop, Peter H; Serlie, Mireille J; la Fleur, Susanne E

    2016-01-01

    Use of artificial light resulted in relative independence from the natural light-dark (LD) cycle, allowing human subjects to shift the timing of food intake and work to convenient times. However, the increase in artificial light exposure parallels the increase in obesity prevalence. Light is the

  16. Spreading the word about the quick clearance law : research spotlight.

    Science.gov (United States)

    2012-09-01

    Motorists traditionally were taught to leave : their vehicles in place after a crash occurred : to make it easier for police to reconstruct : the incident and evaluate who was at fault. : However, the practice of leaving vehicles in : the roadway can...

  17. Soil stabilization with recycled materials improves subgrade performance : research spotlight.

    Science.gov (United States)

    2016-02-29

    The use of recycled materials for subgrade stabilization can provide the support needed for construction vehicle loading and more typical long-term traffic loading. This is a particular need in Michigan due to the prevalence of weak subgrade soils. U...

  18. January Monthly Spotlight: Cervical Health and Cervical Cancer Disparities

    Science.gov (United States)

    In January, CRCHD joins the nation in raising awareness for Cervical Health and Cervical Cancer Disparities. This month we share a special focus on NCI/CRCHD research programs that are trying to reduce cervical cancer disparities in underserved communities and the people who are spreading the word about the importance of early detection.

  19. Spotlight on advances in VTE management: CALLISTO and EINSTEIN CHOICE.

    Science.gov (United States)

    Bach, Miriam; Bauersachs, Rupert

    2016-09-28

    Venous thromboembolism (VTE) is associated with numerous complications and high mortality rates. Patients with cancer are at high risk of developing cancer-associated thrombosis (CAT), and VTE recurrence is common. Evidence supporting use of non-vitamin K antagonist (VKA) oral anticoagulants (NOACs) in patients with cancer is lacking - direct comparisons between NOACs and low-molecular-weight heparin (LMWH) are needed, along with patient-reported outcomes. Cancer Associated thrombosis - expLoring soLutions for patients through Treatment and Prevention with RivarOxaban (CALLISTO) is an international research programme exploring the potential of the direct, oral factor Xa inhibitor rivaroxaban for the prevention and treatment of CAT, supplementing existing data from EINSTEIN DVT and EINSTEIN PE. Here, we focus on four CALLISTO studies: A Study to Evaluate the Efficacy and Safety of Rivaroxaban Venous Thromboembolism Prophylaxis in Ambulatory Cancer Participants receiving Chemotherapy (CASSINI), Anticoagulation Therapy in SELECTeD Cancer Patients at Risk of Recurrence of Venous Thromboembolism (SELECT-D), Rivaroxaban in the Treatment of Venous Thromboembolism in Cancer Patients - a Randomized Phase III Study (CONKO-011) and a database analysis. Optimal anticoagulation duration for VTE treatment has always been unclear. Following favourable results for rivaroxaban 20 mg once-daily (Q. D.) for secondary VTE prevention (EINSTEIN EXT), EINSTEIN CHOICE is assessing rivaroxaban safety and (20 mg Q. D. or 10 mg Q. D.) vs acetylsalicylic acid (ASA), and will investigate whether an alternative rivaroxaban dose (10 mg Q. D.) could offer long-term VTE protection. It is anticipated that results from these studies will provide important answers and expand upon current evidence for rivaroxaban in VTE management.

  20. INCIDENCIA ECONÓMICA, CULTURAL Y TURÍSTICA, EN LAS NECESIDADES INSATISFECHAS DE LA COMUNA SAN PABLO CANTÓN SANTA ELENA, PROVINCIA SANTA ELENA AÑO 2015

    Directory of Open Access Journals (Sweden)

    Karina Isabel Bricio Samaniego

    2016-12-01

    Full Text Available Resumen La presente investigación tiene como objetivo principal analizar los aspectos: culturales, económicos, y turísticos de la comuna San Pablo, que permita identificar las necesidades insatisfechas en la Comuna, en la actualidad está compuesta por la zona económica que se encuentra conformada por negocios comerciales de diferentes productos o servicios, la zona empresarial conformada por numerosos laboratorios de crianza de larvas de camarón, empresas industriales pesqueras, nuevos negocios o microempresas familiares de diversas actividades económicas o productivas. Para la elaboración de este trabajo se utilizó la metodología basada en investigación cuantitativa y cualitativa. Se describió las características generales de la problemática existente, permitiendo elaborar una diagnostico situacional de tipo integral, identificando los programas, proyectos y acciones que van a ser evaluados mediante indicadores de gestión de eficiencia, y eficacia, con la implementación de estrategias como son los convenios con las instituciones del estado, capacitación a los directivos para realizar una eficiente administración comunal, buen trabajo en equipo, ejecución de programas y proyectos, participación oportuna de los habitantes para el logro de un crecimiento permanente para la comuna, sus organizaciones y asociaciones ubicadas dentro de su territorio. Palabras clave: Aspectos económicos, sociales, culturales, Comunas, desarrollo turístico Abstract he present investigation has as main objective to analyze the aspects: cultural, economic, and tourist of the commune San Pablo that allows to identify the unsatisfied necessities in the Commune, at the present time is composed by the economic area that is confirmed by commercial business of different products or services, the managerial area conformed by numerous laboratories of upbringing of shrimp larva’s, companies industrial fishing and new business or family microempresas of diverse economic or productive activities. For the elaboration of this work the methodology was used based on quantitative and qualitative investigation. It was described the general characteristics of the existent problem, allowing to elaborate one diagnoses situational of integral type, identifying the programs, projects and actions that will be evaluated by means of indicators of administration of efficiency, and effectiveness, with the implementation of strategies like they are the agreements with the institutions of the state, training the directive to carry out an efficient administration communal, good work in team, execution of programs and projects, the inhabitants' opportune participation for the achievement of a permanent growth for the commune, their organizations and associations located inside their territory. Words key: Economic, social, cultural aspects, Communes, tourist developmen

  1. A.L. SOKOVNIN’S PIANO SCHOOL. ELENA RESHETNICHENKO — SOME TRAITS OF THE CREATIVE PORTRAIT

    Directory of Open Access Journals (Sweden)

    MELNIC TAMARA

    2017-06-01

    Full Text Available This article is dedicated to the memory of E. Reshetnicenco — an educator at the General Piano Department, one of the most talented representatives of A. Sokovnin’s piano school. In the creations of romantic composers, which form the basis of the concert repertoire, is captured the figurative and emotional field, the most consonant to the nature of the pianist. At the same time, her interpretations combined an analytical approach to the compositions, a thorough reasoning of details, and disregard of external effects. All these were distinctive features of all Sokovnin’s disciples.

  2. Análisis Estructural de Fallas Geológicas y Potenciales Deslizamientos en Anconcito, Provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Kervin Chunga

    2015-10-01

    Los factores que pueden incrementar la tasa de velocidad de deslizamiento de masas de tierra pueden ser: (1 altasprecipitaciones durante el fenómeno del Niño, y (2 la recurrencia de terremotos locales con magnitud moderada Mw≈5 o el arribo de amplificaciones de ondas sísmicas desde terremotos lejanos con magnitudes mayores de Mw>7. En conclusión, el sector de Anconcito debe ser motivo de análisis en detalle que permita establecer técnicas adecuadas para la recuperación de zona de playa y construcción de espigones que permitirán disminuir la alta energía de las ondas marinas.

  3. Greetings from the Border : World War I in Letters of Russian Soldiers Stationed in Finland / Elena Dubrovskaya

    Index Scriptorium Estoniae

    Dubrovskaya, Elena, 1960-

    2004-01-01

    Soomlaste ja vene sõjaväelaste vaheliste suhete pingestumisest alates 1880ndatest. Esimese maailmasõja ajal Soome suurvürstiriigi territooriumil paiknenud vene sõdurite kirjadest ja vene tsensorite aruannetest soomlaste meelsuse kohta

  4. Pedagogia de la Participacion: Entering Elena Garro's "Un hogar solido" through the Body. Enacting Death and Politics in Mexico

    Science.gov (United States)

    Misemer, Sarah M.

    2009-01-01

    Garro's one-act play offers an unusual combination of corpses and animate actors on stage thus combining life and death in the same body. Garro's piece presents students with an approach to "embodying" Mexican culture and its notions of death. The fusion of death and cultural practices in Mexico is a crucial part of the ongoing project for…

  5. Rahvaste vanglast rahvaste ühisesse perre? : Habsburgide monarhiast slovakkide rahvuslikus mälus / Elena Mannova ; tlk. Mati Laur

    Index Scriptorium Estoniae

    Mannova, Elena

    2006-01-01

    Slovakkia ajalookirjutust alates 1918. aastast kuni tänapäevani mõjutanud rahvusmütoloogiast. Suhtumisest Austria-Ungari kaksikriiki ja Habsburgide dünastiasse ning rahvuslike kannatuste e. orjapõlve müüdi modelleerumisest historiograafias

  6. Beaconless Georouting Under The Spotlight: Practical Link Models and Application Scenarios

    KAUST Repository

    Bader, Ahmed; Abed-Meraim, Karim; Alouini, Mohamed-Slim

    2015-01-01

    practical application scenarios. Furthermore, beaconless georouting protocols have been studied in literature assuming equal communication ranges for the data and control packets. In reality, this is not true since the communication range is actually a

  7. Assessing the value of E-Businesses in emerging markets: Spotlight on Romania

    NARCIS (Netherlands)

    Mazurencu-Marinescu, M.; Nijkamp, P.

    2008-01-01

    The e-bubble of 2000 was followed by a slowdown from 2001 to 2003, but recently the markets are e-bubbling again, especially the emerging ones in growing economies. An increasing number of transactions with e-businesses appears to occur which prompts the need for valuing the firms involved and for

  8. Swine-Flu Plans Put E-Learning in the Spotlight

    Science.gov (United States)

    Davis, Michelle R.; Ash, Katie

    2009-01-01

    Last school year, many educators were caught unprepared when schools closed in response to cases of swine flu. This time around, both the federal government and school districts are putting specific online-learning measures in place to get ready for possible closures or waves of teacher and student absences because of a flu outbreak. To prepare…

  9. Improving mobility and transportation options for Michigan's rural seniors : research spotlight.

    Science.gov (United States)

    2012-12-01

    Mobility challenges faced by older adults in : rural Michigan include long travel distances to obtain basic services or medical : care, and the limited availability of public, : private or volunteer transportation providers. Because of these challeng...

  10. Video Book Trailers: Coming to a Library Near You! Spotlight Feature

    Science.gov (United States)

    Dopke-Wilson, MariRae

    2009-01-01

    This article features two library media specialists who discovered a way to motivate high school students to read. When most people go to the movies, the "coming attractions" or movie trailers are as anticipated as the popcorn! This Americana movie tradition hooks people again and again on what they will come back to see next. So, it's no surprise…

  11. A spotlight on liquefaction: evidence from clinical settings and experimental models in tuberculosis.

    Science.gov (United States)

    Cardona, Pere-Joan

    2011-01-01

    Liquefaction is one of the most intriguing aspects of human tuberculosis. It is a major cause of the transition from the infection to active disease (tuberculosis, TB) as well as the transmission of M. tuberculosis to other persons. This paper reviews the natural history of liquefaction in humans from a pathological and radiological point of view and discusses how the experimental models available can be used to address the topic of liquefaction and cavity formation. Different concepts that have been related to liquefaction, from the influence of immune response to mechanical factors, are reviewed. Synchronic necrosis or apoptosis of infected macrophages in a close area, together with an ineffective fibrosis, appears to be clue in this process, in which macrophages, the immune response, and bacillary load interact usually in a particular scenario: the upper lobes of the lung. The summary would be that even if being a stochastic effect, liquefaction would result if the organization of the intragranulomatous necrosis (by means of fibrosis) would be disturbed.

  12. A Spotlight on Liquefaction: Evidence from Clinical Settings and Experimental Models in Tuberculosis

    Directory of Open Access Journals (Sweden)

    Pere-Joan Cardona

    2011-01-01

    Full Text Available Liquefaction is one of the most intriguing aspects of human tuberculosis. It is a major cause of the transition from the infection to active disease (tuberculosis, TB as well as the transmission of M. tuberculosis to other persons. This paper reviews the natural history of liquefaction in humans from a pathological and radiological point of view and discusses how the experimental models available can be used to address the topic of liquefaction and cavity formation. Different concepts that have been related to liquefaction, from the influence of immune response to mechanical factors, are reviewed. Synchronic necrosis or apoptosis of infected macrophages in a close area, together with an ineffective fibrosis, appears to be clue in this process, in which macrophages, the immune response, and bacillary load interact usually in a particular scenario: the upper lobes of the lung. The summary would be that even if being a stochastic effect, liquefaction would result if the organization of the intragranulomatous necrosis (by means of fibrosis would be disturbed.

  13. De Novo Adult Transcriptomes of Two European Brittle Stars: Spotlight on Opsin-Based Photoreception.

    Directory of Open Access Journals (Sweden)

    Jérôme Delroisse

    Full Text Available Next generation sequencing (NGS technology allows to obtain a deeper and more complete view of transcriptomes. For non-model or emerging model marine organisms, NGS technologies offer a great opportunity for rapid access to genetic information. In this study, paired-end Illumina HiSeqTM technology has been employed to analyse transcriptomes from the arm tissues of two European brittle star species, Amphiura filiformis and Ophiopsila aranea. About 48 million Illumina reads were generated and 136,387 total unigenes were predicted from A. filiformis arm tissues. For O. aranea arm tissues, about 47 million reads were generated and 123,324 total unigenes were obtained. Twenty-four percent of the total unigenes from A. filiformis show significant matches with sequences present in reference online databases, whereas, for O. aranea, this percentage amounts to 23%. In both species, around 50% of the predicted annotated unigenes were significantly similar to transcripts from the purple sea urchin, the closest species to date that has undergone complete genome sequencing and annotation. GO, COG and KEGG analyses were performed on predicted brittle star unigenes. We focused our analyses on the phototransduction actors involved in light perception. Firstly, two new echinoderm opsins were identified in O. aranea: one rhabdomeric opsin (homologous to vertebrate melanopsin and one RGR opsin. The RGR-opsin is supposed to be involved in retinal regeneration while the r-opsin is suspected to play a role in visual-like behaviour. Secondly, potential phototransduction actors were identified in both transcriptomes using the fly (rhabdomeric and mammal (ciliary classical phototransduction pathways as references. Finally, the sensitivity of O.aranea to monochromatic light was investigated to complement data available for A. filiformis. The presence of microlens-like structures at the surface of dorsal arm plate of O. aranea could potentially explain phototactic behaviour differences between the two species. The results confirm (i the ability of these brittle stars to perceive light using opsin-based photoreception, (ii suggest the co-occurrence of both rhabdomeric and ciliary photoreceptors, and (iii emphasise the complexity of light perception in this echinoderm class.

  14. Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine

    Science.gov (United States)

    Allais, Gianni; Benedetto, Chiara

    2016-01-01

    Migraine is a common neurovascular disorder, affecting millions of people worldwide. Current guidelines recommend triptans as first-line treatment for moderate-to-severe migraine attacks. Frovatriptan is a second-generation triptan with a longer terminal elimination half-life in blood than other triptans (~26 hours). Three double-blind, randomized crossover preference studies have been recently conducted, assessing efficacy and safety of frovatriptan versus rizatriptan, zolmitriptan, and almotriptan, respectively. Frovatriptan showed favorable tolerability and sustained effect, with a significantly lower rate of relapse over 48 hours versus the other triptans. These findings were confirmed in a series of analyses of patient subsets from the three studies, including patients with menstrually related and oral contraceptive-induced migraine, hypertension, obesity, weekend migraine, as well as patients with migraine with aura. In all patient subsets analyzed, lower headache recurrence rates were observed versus the comparator triptans, indicating a more sustained pain-relieving effect on migraine symptoms. A further randomized, double-blind study demonstrated that frovatriptan given in combination with the fast-acting cyclooxygenase inhibitor dexketoprofen provided improved migraine pain-free activity at 2 hours, and gave more sustained pain-free activity at 24 hours, versus frovatriptan alone. These benefits were observed both when the combination was administered early (1 hour after onset). Different pharmacokinetic, but synergistic, properties between frovatriptan and dexketoprofen may make the combination of these agents particularly effective in migraine treatment, with rapid onset of action and sustained effect over 48 hours. These benefits, together with potential cost-effectiveness advantages versus other triptans could drive selection of the most appropriate treatment for acute migraine attacks. PMID:27757013

  15. Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine

    Directory of Open Access Journals (Sweden)

    Allais G

    2016-10-01

    Full Text Available Gianni Allais, Chiara Benedetto Department of Surgical Sciences, Women’s Headache Center, University of Turin, Turin, Italy Abstract: Migraine is a common neurovascular disorder, affecting millions of people worldwide. Current guidelines recommend triptans as first-line treatment for moderate-to-severe migraine attacks. Frovatriptan is a second-generation triptan with a longer terminal elimination half-life in blood than other triptans (~26 hours. Three double-blind, randomized crossover preference studies have been recently conducted, assessing efficacy and safety of frovatriptan versus rizatriptan, zolmitriptan, and almotriptan, respectively. Frovatriptan showed favorable tolerability and sustained effect, with a significantly lower rate of relapse over 48 hours versus the other triptans. These findings were confirmed in a series of analyses of patient subsets from the three studies, including patients with menstrually related and oral contraceptive-induced migraine, hypertension, obesity, weekend migraine, as well as patients with migraine with aura. In all patient subsets analyzed, lower headache recurrence rates were observed versus the comparator triptans, indicating a more sustained pain-relieving effect on migraine symptoms. A further randomized, double-blind study demonstrated that frovatriptan given in combination with the fast-acting cyclooxygenase inhibitor dexketoprofen provided improved migraine pain-free activity at 2 hours, and gave more sustained pain-free activity at 24 hours, versus frovatriptan alone. These benefits were observed both when the combination was administered early (<1 hour after symptom onset or late (>1 hour after onset. Different pharmacokinetic, but synergistic, properties between frovatriptan and dexketoprofen may make the combination of these agents particularly effective in migraine treatment, with rapid onset of action and sustained effect over 48 hours. These benefits, together with potential cost-effectiveness advantages versus other triptans could drive selection of the most appropriate treatment for acute migraine attacks. Keywords: migraine, frovatriptan, menstrual, dexketoprofen, triptans, migraine with aura

  16. Netherlands in the spotlight at the ENLIGHT meeting on particle therapy

    CERN Multimedia

    Virginia Greco (CERN) and Manjit Dosanjh (ENLIGHT co-coordinator)

    2016-01-01

    The annual meeting of ENLIGHT, which focuses on particle therapy for cancer treatment, was held in the Netherlands.   Participants of the annual meeting of ENLIGHT, held in the Netherlands from 15-17 September 2016. The annual meeting of ENLIGHT (European Network for Light Hadron Therapy), which gathers experts working worldwide in centres and research institutions for particle therapy for cancer treatment, was hosted this year by the Dutch National Institute for Subatomic Physics (Nikhef) and the University of Utrecht, in the Netherlands, from 15-17 September. Chaired by the co-coordinator of ENLIGHT, Manjit Dosanjh, and the local organisers, Els Koffeman and Jan Visser from Nikhef, the meeting was attended by almost 100 participants from 15 countries. The Netherlands took centre stage at the ENLIGHT meeting: four brand new centres for proton therapy in the Netherlands are currently at various phases of completion as a consequence of the recent approval by the Dutch government of a plan for mak...

  17. Taking flight with sensing equipment will deliver benefits across MDOT : research spotlight.

    Science.gov (United States)

    2015-04-01

    Recent strides in technology have opened the doors for using unmanned : aerial vehicles (UAVs, sometimes called drones) throughout MDOT. An : extensive study on the viability of UAVs instrumented with remote : sensors demonstrated a wide range of cos...

  18. Spotlight on ibrutinib and its potential in frontline treatment of chronic lymphocytic leukemia

    Directory of Open Access Journals (Sweden)

    Khan M

    2017-03-01

    Full Text Available Maliha Khan, Jamie L Gibbons, Alessandra Ferrajoli Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Abstract: Chronic lymphocytic leukemia (CLL is the most prevalent leukemia in the adult population. Current efforts are focused on better understanding the intricate pathophysiology of the disease to develop successful targeted therapies. Ibrutinib is emerging as an important agent in this new age of targeted treatment for CLL. As a Bruton’s tyrosine kinase inhibitor, it blocks the signaling pathway that malignant B-lymphocytes need for growth and maturation. Ibrutinib’s role in therapy was further expanded recently when the US Food and Drug Administration approved its use in both frontline and salvage treatment for patients with CLL. This review assesses the effectiveness of ibrutinib in the frontline setting, its efficacy in various types of patients with CLL, and its safety and tolerability. Keywords: ibrutinib, CLL, frontline therapy

  19. P4-ATPases on the spotlight: lessons from a green world

    DEFF Research Database (Denmark)

    Lopez Marques, Rosa Laura

    flippases, play an essential role in this transport process. We have recently characterized several members of the P4 subfamily of P-type ATPases as prime candidate lipid flippases in the secretory pathway of several eukaryotic cells. Our studies in yeast, plants and mammalian cells uncovered...

  20. Course Placement Series: Spotlight on Eighth Grade Algebra I. Policy Brief

    Science.gov (United States)

    Tennessee Department of Education, 2015

    2015-01-01

    The Tennessee Department of Education explored course enrollment patterns in an effort to better understand in which courses students are enrolling and whether course enrollment policies and procedures are promoting students' interests. This report focuses on eighth grade Algebra I enrollment, which can propel students to take more rigorous math…

  1. RE@21 spotlight: most influential papers from the requirements engineering conference

    NARCIS (Netherlands)

    Glinz, Martin; Wieringa, Roelf J.

    Since 2003, an award has been presented annually at the IEEE International Requirements Engineering Conference for the Most Influential Paper presented at the conference 10 years previously. In 2013, we celebrate 21 years of the Requirements Engineering Conference, and we use this as an opportunity

  2. Human evolution across the disciplines: spotlights on American anthropology and genetics.

    Science.gov (United States)

    Sommer, Marianne

    2012-01-01

    When thinking about human evolution across the disciplines, terms such as "anthropological genetics" or "genetic anthropology" that brazenly defy the existence of the two-cultures divide seem to promise important insights. They refer to the application of genetic techniques to the past of humankind and human groups, a fact emphasized most strongly by the expression "genetic history." Such daring linguistic alliances have been forming since 1962 when the name "molecular anthropology" was introduced in the American context. This was an opportune moment for biochemists and physical chemists to enter anthropology, because in the U.S. a rapprochement between the fields was aimed for. However, a belief in and a discourse of a hierarchy of disciplines structured along the lines of methodology and epistemic object worked as an obstacle to the achievement of transdisciplinarity. Especially the DNA-sequence, initially approached through the proxy of the protein, was regarded as the most informative historical document due to its distance from the environment and its amenability to rigorous scientific techniques. These notions had a particular power at a time when anthropology was confronted with its legacy of race science. For some, the perceived objectivity of the new molecular approaches and the neutrality of molecules would render anthropology more natural-scientific and by inference less culturally contaminated. Others, to the contrary, believed that this legacy demanded a holistic and ethically reflexive anthropology. The different perceptions thus went along with different understandings of such crucial terms as "anthropology" and "history." In the paper, I revisit interfaces between different anthropological fields in the U.S. context and suggest that the beliefs in a hierarchy of approaches as well as in a nature free from culture embodied in the DNA-sequence has worked as one of the primary obstacles to an integration of these fields.

  3. Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date

    Directory of Open Access Journals (Sweden)

    Cinti F

    2017-10-01

    Full Text Available Francesca Cinti,* Simona Moffa,* Flavia Impronta,* Chiara MA Cefalo, Vinsin A Sun, Gian Pio Sorice, Teresa Mezza, Andrea Giaccari Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy *These authors contributed equally to this work Abstract: Sodium-glucose cotransporter 2 (SGLT2 inhibitors are the latest therapeutic strategy in the treatment of type 2 diabetes mellitus (T2DM. Using an insulin-independent mechanism (glycosuria, they reduce glucose toxicity and improve insulin sensitivity and β-cell function. The promising results obtained in clinical trials show that SGLT2 significantly improves glycemic control and provides greater cardiovascular protection, combined with a reduction in body weight and blood pressure (BP. This review focuses on ertugliflozin, a new, highly selective, and reversible SGLT2 inhibitor. Clinical trials published to date show that ertugliflozin, both as a monotherapy and as an add-on to oral antidiabetic agents, is safe and effective in reducing glycosylated hemoglobin (HbA1c, body weight, and BP in T2DM patients. Keywords: antidiabetic drugs, glycosylated hemoglobin, glycemic control, sodium-glucose cotransporter 2 inhibitors, precision medicine, type 1 diabetes mellitus, type 2 diabetes mellitus, weight reduction 

  4. Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy

    Directory of Open Access Journals (Sweden)

    Zhang Hui

    2007-02-01

    Full Text Available Abstract Recent investigation of Cullin 4 (CUL4 has ushered this class of multiprotein ubiquitin E3 ligases to center stage as critical regulators of diverse processes including cell cycle regulation, developmental patterning, DNA replication, DNA damage and repair, and epigenetic control of gene expression. CUL4 associates with DNA Damage Binding protein 1 (DDB1 to assemble an ubiquitin E3 ligase that targets protein substrates for ubiquitin-dependent proteolysis. CUL4 ligase activity is also regulated by the covalent attachment of the ubiquitin-like protein NEDD8 to CUL4, or neddylation, and the COP9 signalosome complex (CSN that removes this important modification. Recently, multiple WD40-repeat proteins (WDR were found to interact with DDB1 and serve as the substrate-recognition subunits of the CUL4-DDB1 ubiquitin ligase. As more than 150–300 WDR proteins exist in the human genome, these findings impact a wide array of biological processes through CUL4 ligase-mediated proteolysis. Here, we review the recent progress in understanding the mechanism of CUL4 ubiquitin E3 ligase and discuss the architecture of CUL4-assembled E3 ubiquitin ligase complexes by comparison to CUL1-based E3s (SCF. Then, we will review several examples to highlight the critical roles of CUL4 ubiquitin ligase in genome stability, cell cycle regulation, and histone lysine methylation. Together, these studies provide insights into the mechanism of this novel ubiquitin ligase in the regulation of important biological processes.

  5. Controlling the spotlight of attention: visual span size and flexibility in schizophrenia.

    Science.gov (United States)

    Elahipanah, Ava; Christensen, Bruce K; Reingold, Eyal M

    2011-10-01

    The current study investigated the size and flexible control of visual span among patients with schizophrenia during visual search performance. Visual span is the region of the visual field from which one extracts information during a single eye fixation, and a larger visual span size is linked to more efficient search performance. Therefore, a reduced visual span may explain patients' impaired performance on search tasks. The gaze-contingent moving window paradigm was used to estimate the visual span size of patients and healthy participants while they performed two different search tasks. In addition, changes in visual span size were measured as a function of two manipulations of task difficulty: target-distractor similarity and stimulus familiarity. Patients with schizophrenia searched more slowly across both tasks and conditions. Patients also demonstrated smaller visual span sizes on the easier search condition in each task. Moreover, healthy controls' visual span size increased as target discriminability or distractor familiarity increased. This modulation of visual span size, however, was reduced or not observed among patients. The implications of the present findings, with regard to previously reported visual search deficits, and other functional and structural abnormalities associated with schizophrenia, are discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

  6. [Edematous and painful leg. Pathophysiology in the spotlight: presentation of a case].

    Science.gov (United States)

    Estalayo-Gutiérrez, B

    2013-01-01

    We report on a 74-year-old woman visually impaired and under treatment with amlodipine, valsartan and thyroid hormone. The patient complained of her unique, edematous and painful leg after a local trauma. The worsening was slow and gradual, affecting walk and state of mind. Several unsuccessful diagnoses were done before suspecting and confirming a Complex Regional Pain Syndrome. Edema disappeared dramatically after amlodipine empirical discontinuation. Pain improved gradually with rehabilitation exercises but, mainly, after gaining skills and self-esteem due to cataract surgery of her unique functional eye. It was necessary to decrease thyroid hormone dosage after a long lasting balance. The sympathetic nervous system role of the case is discussed. Copyright © 2012 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

  7. Spotlight on Athletes With a Disability: Malaysian Newspaper Coverage of the 2012 London Paralympic Games.

    Science.gov (United States)

    Cheong, Jadeera Phaik Geok; Khoo, Selina; Razman, Rizal

    2016-01-01

    This study analyzed newspaper coverage of the 2012 London Paralympic Games by 8 Malaysian newspapers. Articles and photographs from 4 English-language and 4 Malay-language newspapers were examined from August 28 (1 day before the Games) to September 10, 2012 (1 day after the Games closing). Tables, graphs, letters, fact boxes, and lists of events were excluded from analysis. A total of 132 articles and 131 photographs were analyzed. Content analysis of the newspaper articles revealed that most (62.8%) of the articles contained positive reference to the athletes with a disability. There were equal numbers (39.1%) of action and static shots of athletes. More articles and photographs of Malaysian (58%) than non-Malaysian (42%) athletes with a disability were identified. Only 14.9% of the articles and photographs were related to female athletes with a disability.

  8. The spotlight effect and the illusion of transparency in social anxiety

    OpenAIRE

    Brown, Michael A.; Stopa, Lusia

    2007-01-01

    [Clark, D. M., & Wells, A. (1995). A cognitive model of social phobia. In: R. G. Heimberg, M. R. Liebowitz, D. A. Hope, & F. R. Schneier (Eds.), Social phobia: diagnosis, assessment, and treatment (pp. 69–93). New York: Guildford Press] cognitive model of social phobia suggests that both public and private sources of information contribute to the construction of the self as a social object, which is thought to maintain the disorder. This study used two concepts developed i...

  9. Sustainable prevention of obesity through integrated strategies: The SPOTLIGHT project's conceptual framework and design

    NARCIS (Netherlands)

    Lakerveld, J.; Brug, J.; Bot, S.D.M.; Teixeira, P.J.; Rutter, H.; Woodward, E.; Samdal, O.; Stockley, L.; de Bourdeaudhuij, I.; Assema, P.; Robertson, A.; Lobstein, T.; Oppert, J.M.; Adany, R.; Nijpels, G.

    2012-01-01

    Background: The prevalence of overweight and obesity in Europe is high. It is a major cause of the overall rates of many of the main chronic (or non communicable) diseases in this region and is characterized by an unequal socio-economic distribution within the population. Obesity is largely

  10. Tow plows could help Michigan save time and money on winter maintenance : research spotlight.

    Science.gov (United States)

    2016-11-01

    As winter maintenance costs rise, MDOT is looking into innovative approaches to increase snow removal efficiency. As part of this effort, the department recently estimated the costs and benefits of incorporating tow plows into its equipment fleet. Re...

  11. Spotlight on talimogene laherparepvec for the treatment of melanoma lesions in the skin and lymph nodes

    Directory of Open Access Journals (Sweden)

    Orloff M

    2016-10-01

    Full Text Available Marlana Orloff Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA Abstract: On October 27, 2015, talimogene laherparepvec (T-VEC, a first in class intralesional oncolytic virotherapy, was granted the US Food and Drug Administration approval for the treatment of melanoma in the skin and lymph nodes. Its approval has added yet another therapeutic option to the growing list of effective therapies for melanoma. Though the Phase III OPTiM trial has demonstrated its efficacy as a single agent, the target patient population remains narrow. With numerous effective and tolerable treatments available for unresectable and metastatic melanoma, intralesional therapies such as T-VEC are still finding their niche. T-VEC is now widely accepted as option for treatment; however, its combination with various other agents in an effort to expand its use and synergize with other interventions is still being explored. This article will review the pre-clinical and clinical work that eventually led to the Food and Drug Administration approval of this first-in-class agent, as well as address concerns about clinical application and ongoing research. Keywords: T-VEC, talimogene laherparepvec intralesional, melanoma, oncolytic virus, virotherapy, immunotherapy

  12. The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer.

    Science.gov (United States)

    Esteban-Jurado, Clara; Franch-Expósito, Sebastià; Muñoz, Jenifer; Ocaña, Teresa; Carballal, Sabela; López-Cerón, Maria; Cuatrecasas, Miriam; Vila-Casadesús, Maria; Lozano, Juan José; Serra, Enric; Beltran, Sergi; Brea-Fernández, Alejandro; Ruiz-Ponte, Clara; Castells, Antoni; Bujanda, Luis; Garre, Pilar; Caldés, Trinidad; Cubiella, Joaquín; Balaguer, Francesc; Castellví-Bel, Sergi

    2016-10-01

    Colorectal cancer (CRC) is one of the most common neoplasms in the world. Fanconi anemia (FA) is a very rare genetic disease causing bone marrow failure, congenital growth abnormalities and cancer predisposition. The comprehensive FA DNA damage repair pathway requires the collaboration of 53 proteins and it is necessary to restore genome integrity by efficiently repairing damaged DNA. A link between FA genes in breast and ovarian cancer germline predisposition has been previously suggested. We selected 74 CRC patients from 40 unrelated Spanish families with strong CRC aggregation compatible with an autosomal dominant pattern of inheritance and without mutations in known hereditary CRC genes and performed germline DNA whole-exome sequencing with the aim of finding new candidate germline predisposition variants. After sequencing and data analysis, variant prioritization selected only those very rare alterations, producing a putative loss of function and located in genes with a role compatible with cancer. We detected an enrichment for variants in FA DNA damage repair pathway genes in our familial CRC cohort as 6 families carried heterozygous, rare, potentially pathogenic variants located in BRCA2/FANCD1, BRIP1/FANCJ, FANCC, FANCE and REV3L/POLZ. In conclusion, the FA DNA damage repair pathway may play an important role in the inherited predisposition to CRC.

  13. Out of the SHADOW: watch parts in the spotlight -- laser beam microwelding of delicate watch components

    Science.gov (United States)

    Kramer, Thorsten; Olowinsky, Alexander M.

    2003-07-01

    Conventional joining techniques like press fitting or crimping require the application of mechanical forces to the parts which, in combination with the tolerances of both parts to be joined, lead to imprecision and poor tensile strength. In contrast, laser beam micro welding provides consistent joining and high flexibility and it acts as an alternative as long as press fitting, crimping, screwing or gluing are not capable of batch production. Different parts and even different metals can be joined in a non-contact process at feed rates of up to 60 m/min and with weld seam lengths from 0.6 mm to 15.7 mm. Due to the low energy input, typically 1 J to 6 J, a weld width as small as 50 μm and a weld depth as small as 20 μm have been attained. This results in low distortion of the joined watch components. Since the first applications of laser beam micro welding of watch components showed promising results, the process has further been enhanced using the SHADOW technique. Aspects of the technique such as tensile strength, geometry and precision of the weld seam as well as the acceptance amongst the -mostly conservative- watch manufacturers have been improved.

  14. Maternal Prenatal Stress and Other Developmental Risk Factors for Adolescent Depression: Spotlight on Sex Differences.

    Science.gov (United States)

    Maxwell, Seth D; Fineberg, Anna M; Drabick, Deborah A; Murphy, Shannon K; Ellman, Lauren M

    2018-02-01

    Maternal stress during pregnancy has been linked to premorbid abnormalities associated with depression (e.g., difficult temperament, cognitive deficits) in offspring. However, few studies have looked across developmental periods to examine maternal stress during pregnancy and offspring depression during adolescence and whether these associations differ by sex. The current study used data from 1711 mother-offspring dyads (offspring sex: 49.8% male) in a longitudinal birth cohort study. Maternal narratives collected during pregnancy were qualitatively coded for stress-related themes by independent raters. Latent class analysis (LCA) identified distinct subgroups of offspring based on exposure to maternal prenatal stress and other developmental factors from the prenatal, childhood, and adolescent periods that have been associated with depression and/or maternal prenatal stress. LCA identified subgroups that were compared to determine whether and to what extent they differed on adolescent depressive symptoms. LCA revealed a subgroup of "high-risk" individuals, characterized by maternal factors during pregnancy (higher ambivalence/negativity and lower positivity towards the pregnancy, higher levels of hassles, lower maternal education and higher maternal age at birth, higher pre-pregnancy BMI) and offspring developmental factors (decreased cognitive functioning during childhood and adolescence, lower perceived parental support during adolescence, and higher levels of maternal depression during adolescence). High-risk females exhibited elevated conduct symptoms and higher birth order, while high-risk males exhibited decreased internalizing symptoms and lower birth order. Both high-risk males and females reported elevated depressive symptoms during adolescence relative to their "low-risk" counterparts.

  15. State Data Use Spotlight: North Carolina. Transforming State Systems to Improve Outcomes for Children with Disabilities

    Science.gov (United States)

    Ruedel, Kristin; Nelson, Gena; Bailey, Tessie; Bradley-Black, Katherine

    2018-01-01

    North Carolina Department of Public Instruction (NCDPI) is focused on improving the 5-year graduation rates for all students with disabilities. To make progress toward the state-identified measurable result (SIMR), the state recognized that a single evidence-based practice (EBP) would not address the diverse needs of all the local entities across…

  16. Program Spotlight: Ground Broken for NCI-supported Cancer Treatment Center in Puerto Rico

    Science.gov (United States)

    Dr. Sanya A. Springfield represented NCI at the groundbreaking ceremonies for the University of Puerto Rico (UPR) cancer hospital. In her remarks, she acknowledged the driving force behind this development is the UPR and the MD Anderson Cancer Center partnership.

  17. Grantee Spotlight: Dr. Meena Jaggi - Investigating Curcumin (Turmeric) as HPV Repressor for Native A

    Science.gov (United States)

    Dr. Meena Jaggi’s research, funded by an NCI/CRCHD U01 grant, involves the use of curcumin (commonly known as turmeric) to inhibit human papillomavirus (HPV) infection among Native American (NA) women.

  18. Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers.

    Science.gov (United States)

    Park, Dongseok; Bae, Sungwon; Yoon, Taek Han; Ko, Jaewon

    2018-04-18

    Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying this property are only recently being unveiled. Recent studies highlight several classes of cell-surface proteins as organizing hubs in building structural and functional architectures of specific synapses and neural circuits. In the present minireview, we discuss recent findings on various synapse organizers that confer the distinct properties of specific synapse types and neural circuit architectures in mammalian brains, with a particular focus on the hippocampus and cerebellum.

  19. Spotlight on valsartan-sacubitril fixed-dose combination for heart failure: the evidence to date.

    Science.gov (United States)

    Vilela-Martin, José Fernando

    2016-01-01

    Heart failure is a global problem with elevated prevalence, and it is associated with substantial cardiovascular morbidity and mortality. Treating heart-failure patients has been a very challenging task. This review highlights the main pharmacological developments in the field of heart failure with reduced ejection fraction, giving emphasis to a drug that has a dual-acting inhibition of the neprilysin and renin-angiotensin-aldosterone system. Neprilysin is an enzyme that participates in the breakdown of biologically active natriuretic peptides and several other vasoactive compounds. The inhibition of neprilysin has been a therapeutic target for several drugs tested in cardiovascular disease, mainly for heart failure and/or hypertension. However, side effects and a lack of efficacy led to discontinuation of their development. LCZ696 is a first-in-class neprilysin- and angiotensin-receptor inhibitor that has been developed for use in heart failure. This drug is composed of two molecular moieties in a single crystalline complex: a neprilysin-inhibitor prodrug (sacubitril) and the angiotensin-receptor blocker (valsartan). The PARADIGM-HF trial demonstrated that this drug was superior to an angiotensin-converting enzyme inhibitor (enalapril) in reducing mortality in patients with heart failure with reduced ejection fraction. The ability to block the angiotensin receptor and augment the endogenous natriuretic peptide system provides a distinctive mechanism of action in cardiovascular disease.

  20. Spotlight on valsartan–sacubitril fixed-dose combination for heart failure: the evidence to date

    Science.gov (United States)

    Vilela-Martin, José Fernando

    2016-01-01

    Heart failure is a global problem with elevated prevalence, and it is associated with substantial cardiovascular morbidity and mortality. Treating heart-failure patients has been a very challenging task. This review highlights the main pharmacological developments in the field of heart failure with reduced ejection fraction, giving emphasis to a drug that has a dual-acting inhibition of the neprilysin and renin–angiotensin–aldosterone system. Neprilysin is an enzyme that participates in the breakdown of biologically active natriuretic peptides and several other vasoactive compounds. The inhibition of neprilysin has been a therapeutic target for several drugs tested in cardiovascular disease, mainly for heart failure and/or hypertension. However, side effects and a lack of efficacy led to discontinuation of their development. LCZ696 is a first-in-class neprilysin- and angiotensin-receptor inhibitor that has been developed for use in heart failure. This drug is composed of two molecular moieties in a single crystalline complex: a neprilysin-inhibitor prodrug (sacubitril) and the angiotensin-receptor blocker (valsartan). The PARADIGM-HF trial demonstrated that this drug was superior to an angiotensin-converting enzyme inhibitor (enalapril) in reducing mortality in patients with heart failure with reduced ejection fraction. The ability to block the angiotensin receptor and augment the endogenous natriuretic peptide system provides a distinctive mechanism of action in cardiovascular disease. PMID:27274196

  1. Spotlight on valsartan–sacubitril fixed-dose combination for heart failure: the evidence to date

    Directory of Open Access Journals (Sweden)

    Vilela-Martin JF

    2016-05-01

    Full Text Available José Fernando Vilela-Martin Internal Medicine Department, São José do Rio Preto State Medical School (FAMERP, São José do Rio Preto, Brazil Abstract: Heart failure is a global problem with elevated prevalence, and it is associated with substantial cardiovascular morbidity and mortality. Treating heart-failure patients has been a very challenging task. This review highlights the main pharmacological developments in the field of heart failure with reduced ejection fraction, giving emphasis to a drug that has a dual-acting inhibition of the neprilysin and renin–angiotensin–aldosterone system. Neprilysin is an enzyme that participates in the breakdown of biologically active natriuretic peptides and several other vasoactive compounds. The inhibition of neprilysin has been a therapeutic target for several drugs tested in cardiovascular disease, mainly for heart failure and/or hypertension. However, side effects and a lack of efficacy led to discontinuation of their development. LCZ696 is a first-in-class neprilysin- and angiotensin-receptor inhibitor that has been developed for use in heart failure. This drug is composed of two molecular moieties in a single crystalline complex: a neprilysin-inhibitor prodrug (sacubitril and the angiotensin-receptor blocker (valsartan. The PARADIGM-HF trial demonstrated that this drug was superior to an angiotensin-converting enzyme inhibitor (enalapril in reducing mortality in patients with heart failure with reduced ejection fraction. The ability to block the angiotensin receptor and augment the endogenous natriuretic peptide system provides a distinctive mechanism of action in cardiovascular disease. Keywords: heart failure, vasopeptidase, natriuretic peptides, neprilysin, sacubitril, valsartan

  2. Angioedema Spotlight: A Closer Examination of Sacubitril/Valsartan Safety Results.

    Science.gov (United States)

    Owens, Ryan E; Oliphant, Carrie S

    2017-01-01

    Incorporation of neprilysin inhibition into heart failure pharmacotherapy regimens has recently been recommended by U.S. guidelines, based on results from the PARADIGM-HF trial comparing sacubitril/valsartan to enalapril. While most of the discussion has focused on efficacy, a closer examination of the safety results, particularly the incidence of angioedema during the run-in and double-blind periods, is also warranted. Although no major safety concerns were identified, an angioedema risk comparable to enalapril was found, primarily in the black population. Therefore, despite combination with an angiotensin receptor blocker, which historically has a lower incidence of angioedema, the addition of neprilysin inhibition yields an angioedema risk profile comparable to angiotensin converting enzyme (ACE) inhibitors. Clinicians should recognize this safety risk when prescribing sacubitril/valsartan and remain vigilant in counseling patients regarding the signs and symptoms of angioedema. As recommended by the guidelines, avoiding sacubitril/valsartan use concurrently or within 36 hours of the last dose of an ACE inhibitor or in patients with a history of angioedema is also crucial to minimize angioedema risk and prevent patient harm. © Copyright 2017 by the American Board of Family Medicine.

  3. Achieving Quality Education in Ghana: The Spotlight on Primary Education within the Kumasi Metropolis

    Science.gov (United States)

    Boakye-Amponsah, Abraham; Enninful, Ebenezer Kofi; Anin, Emmanuel Kwabena; Vanderpuye, Patience

    2015-01-01

    Background: Ghana being a member of the United Nations, committed to the Universal Primary Education initiative in 2000 and has since implemented series of educational reforms to meet the target for the Millennium Development Goal (MDG) 2. Despite the numerous government interventions to achieve the MDG 2, many children in Ghana have been denied…

  4. Course Placement Series: Spotlight on High School Math Course Enrollment. Policy Brief

    Science.gov (United States)

    Tennessee Department of Education, 2015

    2015-01-01

    The Tennessee Department of Education explored course enrollment patterns in an effort to better understand in which courses students are enrolling and whether course enrollment policies and procedures are promoting students' interests. This report focuses on math course enrollment patterns throughout high school by following the 2013-14 twelfth…

  5. Spotlight on RESA 6: Regional Implementation of the Learning School Initiative. Catalyst Schools Research Study Report

    Science.gov (United States)

    Hammer, Patricia Cahape

    2016-01-01

    West Virginia's Regional Education Service Agency 6 (RESA 6) serves five districts in the northern panhandle of the state--Brooke, Hancock, Marshall, Ohio, and Wetzel--which together are home to 51 schools. RESA 6 joined the pilot implementation of the Learning School approach in the summer of 2015, as part of the second cohort. RESA 6's group…

  6. Spotlight on RESA 2: Regional Implementation of the Learning School Initiative. Catalyst Schools Research Study Report

    Science.gov (United States)

    Hammer, Patricia Cahape

    2016-01-01

    West Virginia's Regional Education Service Agency 2 (RESA 2) serves six districts in the southwestern part of the state--Cabell, Lincoln, Logan, Mason, Mingo, Wayne--which together have 95 schools. RESA 2 was one of two RESAs to pilot implementation of the Learning School approach, beginning in the summer of 2014. RESA 2's first cohort included…

  7. Beaconless Georouting Under The Spotlight: Practical Link Models and Application Scenarios

    KAUST Repository

    Bader, Ahmed

    2015-06-18

    Beaconless georouting has emerged as a viable packetforwarding technique in distributed wireless networks, particularly for applications requiring portability and scalability. In this paper, we focus on fine-tuning and developing the analytical tools associated with the study of beaconless georouting protocols. For instance, they have been traditionally analyzed and simulated from the perspective of a single hop only. However, end-to-end performance analysis is instrumental when considering practical application scenarios. Furthermore, beaconless georouting protocols have been studied in literature assuming equal communication ranges for the data and control packets. In reality, this is not true since the communication range is actually a function of the packet length (among other factors). Control packets are typically much shorter than data packets. As a consequence, a substantial discrepancy exists in practice between their respective communication ranges, causing many data packet drops. Accordingly, we introduce two simple strategies for bridging the gap between the control and data packet communication ranges. Our primary objective in this paper is to construct a realistic analysis describing the end-to-end performance of beaconless georouting protocols. Two flagship protocols are selected in this paper for further investigation. For a better perspective, the two protocols are actually compared to a hypothetical limit case, one which offers optimal energy and latency performance. Finally, we present four different application scenarios. For each scenario, we highlight the georouting protocol which performs the best and discuss the reasons behind it. © 2007-2012 IEEE.

  8. Spotlight on rituximab in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis: current perspectives

    Directory of Open Access Journals (Sweden)

    Moog P

    2015-11-01

    Full Text Available Philipp Moog, Klaus Thuermel Abteilung für Nephrologie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany Abstract: A 54-year-old patient presented to his general practitioner because of strong muscle pain in both thighs. Inflammatory parameters (CRP 16.3 mg/dL and white blood cells (15 g/L were elevated. The patient reported a weight loss of 10 kg in 4 weeks. There was no fever or any other specific symptoms. Urine dipstick examination and computed tomography of the chest were unremarkable. Because of increasing symptoms, the patient was referred to our department. Magnetic resonance tomography showed diffuse inflammatory changes of the muscles of both thighs. Neurological examination and electrophysiology revealed axonal sensorimotor neuropathy and ground-glass opacities of both lungs had occurred. Serum creatinine increased to 229 µmol/L within a few days, with proteinuria of 3.3 g/g creatinine. Kidney biopsy showed diffuse pauci-immune proliferative glomerulonephritis. Proteinase 3-specific antineutrophil cytoplasmic antibodies were markedly increased. Birmingham Vasculitis Activity Score was 35. Within 2 days, serum creatinine further increased to 495 µmol/L. Plasma exchange, high-dose glucocorticosteroids, and hemodialysis were started. The patient received cyclophosphamide 1 g twice and rituximab 375 mg/m2 four times according to the RITUXVAS protocol. Despite ongoing therapy, hemodialysis could not be withdrawn and had to be continued over 3 weeks until diuresis normalized. Glucocorticosteroids were tapered to 20 mg after 2 months, and serum creatinine was 133 µmol/L. However, nephritic urinary sediment reappeared. Another dose of 1 g cyclophosphamide was given, and glucocorticosteroids were raised for another 4 weeks. After 6 months, the daily prednisolone dose was able to be tapered to 5 mg. Serum creatinine was 124 µmol/L, proteinuria further decreased to 382 mg/g creatinine, and the Birmingham Vasculitis Activity Score was 0. Maintenance therapy with rituximab 375 mg/m2 every 6 months was started. At the last visit after 8 months, the patient was still in remission, with only minor persistent dysesthesia of the left foot and a persistent serum creatinine of 133 µmol/L. Keywords: ANCA, GPA, granulomatosis with polyangiitis, MPA, microscopic polyangiitis, management

  9. Shifting the Spotlight of Attention: Evidence for Discrete Computations in Cognition

    OpenAIRE

    Buschman, Timothy J.; Miller, Earl K.

    2010-01-01

    Our thoughts have a limited bandwidth; we can only fully process a few items in mind simultaneously. To compensate, the brain developed attention, the ability to select information relevant to the current task, while filtering out the rest. Therefore, by understanding the neural mechanisms of attention we hope to understand a core component of cognition. Here, we review our recent investigations of the neural mechanisms underlying the control of visual attention in frontal and parietal cor...

  10. Generation Me in the spotlight : Linking reality TV to materialism, entitlement, and narcissism

    NARCIS (Netherlands)

    Opree, S.J.; Kühne, R.

    2016-01-01

    Today’s youth, the Generation Me, is deemed materialistic, entitled, and narcissistic. Individuality has become an important value in child-rearing and is cultivated in the media—especially within the reality TV genre. The aim of this study was to investigate whether adolescents’ and emerging

  11. Inclusive education: A transformation and human rights agenda under spotlight in South Africa

    Directory of Open Access Journals (Sweden)

    Mbulaheni Maguvhe

    2015-11-01

    Full Text Available This study investigated the progress made in the implementation of inclusive education as a transformation and human rights tool since its inception in 2001. The study was conducted upon realising that most people underestimate the transformation and human rights value that inclusive education strives to maintain. The total number of participants interviewed was 84. Data was collected using semi-structured interview schedules for the teachers and community members, whereafter it was presented in thematic sections and qualitatively examined for meaning. The results showed that participants comprising teachers and community members do not know or understand the transformational and human rights value of inclusive education. The participants seemed to be equally aware of inclusive education, but they rated its success and value differently. The participants concurred that the philosophy of inclusive education was noble, but they differed regarding the extent to which it had transformed, added value or played an advocacy role in the lives of learners and the community at large over the years.

  12. PACHE Trainee Spotlight: Roslyn Curry Featured on Thesis Thursday Radio Show

    Science.gov (United States)

    Roslyn Curry, a student at the University of Arizona (UA), was featured on a local radio program, Thesis Thursday, where she discussed her participation in the U54 PACHE Partnership for Native American Cancer Prevention (NACP) as a research trainee in Dr. William Montfort’s Lab at the University of Arizona Cancer Cente

  13. Research Spotlight: Model suggests path to ending the ongoing Haitian cholera epidemic

    Science.gov (United States)

    Schultz, Colin

    2011-05-01

    Since early November 2010 a deadly cholera epidemic has been spreading across the Caribbean nation of Haiti, killing thousands of people and infecting hundreds of thousands. While infection rates are being actively monitored, health organizations have been left without a clear understanding of exactly how the disease has spread across Haiti. Cholera can spread through exposure to contaminated water, and the disease travels over long distances if an infected individual moves around the country. Using representations of these two predominant dispersion mechanisms, along with information on the size of the susceptible population, the number of infected individuals, and the aquatic concentration of the cholera-causing bacteria for more than 500 communities, Bertuzzo et al. designed a model that was able to accurately reproduce the progression of the Haitian cholera epidemic. (Geophysical Research Letters, doi:10.1029/2011GL046823, 2011)

  14. Spotlight on nivolumab in the treatment of renal cell carcinoma: design, development, and place in therapy

    Directory of Open Access Journals (Sweden)

    Venur VA

    2017-04-01

    Full Text Available Vyshak Alva Venur,1 Monika Joshi,2 Kenneth G Nepple,3 Yousef Zakharia1 1Division of Hematology Oncology and Bone Marrow Transplant, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 2Division of Hematology-Oncology, Penn State Cancer Institute, Hershey, PA, 3Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA Abstract: Several tyrosine kinase inhibitors targeting the vascular endothelial growth factor receptors and molecules inhibiting the mammalian target of rapamycin are being used for management of metastatic renal cell carcinoma (mRCC; however, there is still a potential for improvement. Immune checkpoint inhibitors like nivolumab and other PD-1/PD-L1 inhibitors provide an alternative approach for patients with mRCC. In this article, the authors review the safety profile and outcomes of phase 1, 2, and 3 clinical trials of nivolumab in mRCC. Keywords: renal cell carcinoma, kidney cancer, PD-1, nivolumab, immunotherapy

  15. Spotlight on the presenter : a study into presentations of conference papers with PowerPoint

    NARCIS (Netherlands)

    Hertz, B.

    2015-01-01

    Abstract

    1. Introduction

    PowerPoint is the most widely used presentation software tool. As of 2012, PowerPoint had more than 200 million presenters worldwide. Presenters all over the world use the program. Some use it for university teaching, others

  16. Program Spotlight: Dana Farber/Harvard Cancer Center Partnership Receives $8 Million Grant

    Science.gov (United States)

    The UMass Boston and Dana Farber/Harvard Cancer Center PACHE Partnership received a grant to start-up a Center for Personalized Cancer Therapy on the UMass Boston campus. The center is deigned to train underrepresented students to work in cancer research.

  17. Spotlighting a Silent Category of Young Females: The Life Experiences of "House Girls" in Turkey

    Science.gov (United States)

    Celik, Kezban; Lukuslu, Demet

    2012-01-01

    This article examines the everyday life experiences of young women in Turkey known as "ev kizi" or "house girls." The article explores how traditional gender roles and family structure in Turkish society limit their full participation in political, economic, and public life. The study is based on in-depth interviews conducted…

  18. MDOT innovation leading to faster, longer-lasting pavement repairs : research spotlight.

    Science.gov (United States)

    2015-01-01

    Current methods of patching pavement must evolve to meet increasing mobility demands. : To address this need, MDOT has been testing a new generation of rapid set full-depth : pavement repair materials. Initial results are promising. The new materials...

  19. Spotlighting the role of photodynamic therapy in cutaneous malignancy: an update and expansion.

    Science.gov (United States)

    Ross, Kate; Cherpelis, Basil; Lien, Mary; Fenske, Neil

    2013-12-01

    Topical photodynamic therapy (PDT) is an option for the treatment of cutaneous malignancy. To present an update and expansion on a previous review of the use of PDT in the current literature in the treatment of actinic keratoses (AK), superficial and nodular basal cell carcinoma (sBCC, nBCC), squamous cell carcinoma (SCC), Bowen's disease, cutaneous T cell lymphoma (CTCL), malignant melanoma, and its use in chemoprevention. Extensive PubMed search January 2013. We find sufficient evidence to recommend the use of PDT in certain patients in the treatment of AK, Bowen's disease, sBCC, and nBCC. It is especially useful in those with contraindications to surgery, widespread areas of involvement, and large lesions. Not only can it be considered superior to other therapies as far as recovery time, tolerance, and cosmetic outcomes, but it also should be considered, when indicated, as first-line treatment in the above conditions. Investigations continue for the use of PDT in the treatment of melanoma, SCC, chemoprevention, and CTCL. © 2013 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

  20. State Systems Change Spotlight: Nevada. Transforming State Systems to Improve Outcomes for Children with Disabilities

    Science.gov (United States)

    Ruedel, Kristin; Nelson, Gena; Bailey, Tessie; Pierce, Jennifer

    2018-01-01

    Data show that effective and ongoing communication and evaluation can have a positive impact on local and statewide systems change. Local and statewide systems change requires ongoing communication and evaluation. The Nevada Department of Education (NDE) used a communication protocol to support implementation of the Assess-Plan-Teach (APT) model.…

  1. Moral Development and Behaviour under the Spotlight of the Neurobiological Sciences

    Science.gov (United States)

    Narvaez, Darcia; Vaydich, Jenny L.

    2008-01-01

    With the aid of techniques such as functional magnetic resonance imaging, neuroscience is providing a new perspective on human behaviour. Many areas of psychology have recognised and embraced the new technologies, methodologies and relevant findings. But how do the tools of neuroscience affect the fields of moral development and moral education?…

  2. DNA methylation as a dynamic regulator of development and disease processes: spotlight on the prostate.

    Science.gov (United States)

    Keil, Kimberly P; Vezina, Chad M

    2015-01-01

    Prostate development, benign hyperplasia and cancer involve androgen and growth factor signaling as well as stromal-epithelial interactions. We review how DNA methylation influences these and related processes in other organ systems such as how proliferation is restricted to specific cell populations during defined temporal windows, how androgens elicit their actions and how cells establish, maintain and remodel DNA methylation in a time and cell specific fashion. We also discuss mechanisms by which hormones and endocrine disrupting chemicals reprogram DNA methylation in the prostate and elsewhere and examine evidence for a reawakening of developmental epigenetic pathways as drivers of prostate cancer and benign prostate hyperplasia.

  3. Sustainable prevention of obesity through integrated strategies: The SPOTLIGHT project’s conceptual framework and design

    OpenAIRE

    Lakerveld, Jeroen; Brug, Johannes; Bot, Sandra; Teixeira, Pedro J.; Rutter, Harry; Woodward, Euan; Samdal, Oddrun; Stockley, Lynn; De Bourdeaudhuij, Ilse; van Assema, Patricia; Robertson, Aileen; Lobstein, Tim; Oppert, Jean-Michel; Ádany, Róza; Nijpels, Giel

    2012-01-01

    Abstract Background The prevalence of overweight and obesity in Europe is high. It is a major cause of the overall rates of many of the main chronic (or non communicable) diseases in this region and is characterized by an unequal socio-economic distribution within the population. Obesity is largely determined by modifiable lifestyle behaviours such as low physical activity levels, sedentary behaviour and consumption of energy dense diets. It is increasingly being recognised that effective res...

  4. The size and shape of the attentional "spotlight" varies with differences in sports expertise.

    Science.gov (United States)

    Hüttermann, Stefanie; Memmert, Daniel; Simons, Daniel J

    2014-06-01

    Focused attention enhances processing of some aspects of the world at the expense of unattended items. Although focused attention has been studied for decades, few studies have measured individual and group differences in how people distribute attention. In three studies, we explored differences in the breadth and distribution of attention as a function of athletic expertise. Study 1 found 25% greater attention breadth in expert athletes than in novices. Study 2 found that the distribution of focused attention for experts varied as a function of the type of athletic expertise: Experts in sports that demand greater horizontal distribution of attention (e.g., soccer) showed greater horizontal breadth of attention than did those whose sports demand more vertical attention (e.g., volleyball), and vice versa. Study 3 used a slightly modified design to replicate the results of Studies 1 and 2. Overall, the findings reveal a systematic association between the measured "shape" of focused attention in a laboratory task and expertise in a real-world skill. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  5. Spotlight on measles 2010: measles outbreak in Ireland 2009-2010.

    LENUS (Irish Health Repository)

    Gee, S

    2010-01-01

    Measles cases are increasing in Ireland, with 320 cases notified since August 2009. Nearly two-thirds of these cases (n=206) were unvaccinated. In the early stages of the outbreak a substantial number of cases were linked to the Traveller community with some cases also reported among the Roma community, other citizens from eastern Europe and children whose parents objected to vaccination. By February 2010, there had been considerable spread to the general population.

  6. Race and ethnicity in the workplace: spotlighting the perspectives of historically stigmatized groups.

    Science.gov (United States)

    Plaut, Victoria C; Thomas, Kecia M; Hebl, Michelle R

    2014-10-01

    Racial and ethnic identity matter and are salient for people in the workplace--a place where people spend a substantial amount of their time. This special issue brings the workplace into the domain of racial and ethnic minority psychology. It also brings to the study of the workplace a relatively neglected perspective: that of people from historically stigmatized racial and ethnic groups. Though there is, of course, need for more work with different themes, outcomes, and populations, this special issue takes us an important step in the direction of understanding better and giving voice to the experiences of racial and ethnic minorities in the workplace. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  7. Donkey Kong in Little Bear Country: A First Grader's Composing Development in the Media Spotlight.

    Science.gov (United States)

    Dyson, Anne Haas

    2001-01-01

    Draws on data collected in an ethnographic project in an urban first grade to examine how media use informs child composing. Focuses on the influence of visual media involving animation. Concludes with a consideration of the teaching challenges posed, and opportunities offered, by the children's media use. (Author)

  8. A spotlight on preschool: the influence of family factors on children's early literacy skills.

    Directory of Open Access Journals (Sweden)

    Steve M Heath

    Full Text Available Phonological awareness, letter knowledge, oral language (including sentence recall and rapid automatised naming are acknowledged within-child predictors of literacy development. Separate research has identified family factors including socio-economic status, parents' level of education and family history. However, both approaches have left unexplained significant amounts of variance in literacy outcomes. This longitudinal study sought to improve prospective classification accuracy for young children at risk of literacy failure by adding two new family measures (parents' phonological awareness and parents' perceived self-efficacy, and then combining the within-child and family factors.Pre-literacy skills were measured in 102 four year olds (46 girls and 56 boys at the beginning of Preschool, and then at the beginning and end of Kindergarten, when rapid automatised naming was also measured. Family factors data were collected at the beginning of Preschool, and children's literacy outcomes were measured at the end of Year 1 (age 6-7 years.Children from high-risk backgrounds showed poorer literacy outcomes than low-risk students, though three family factors (school socio-economic status, parents' phonological awareness, and family history typically accounted for less Year 1 variance than the within-child factors. Combining these family factors with the end of Kindergarten within-child factors provided the most accurate classification (i.e., sensitivity = .85; specificity = .90; overall correct = .88.Our approach would identify at-risk children for intervention before they began to fail. Moreover, it would be cost-effective because although few at-risk children would be missed, allocation of unnecessary educational resources would be minimised.

  9. NCI Core Open House Shines Spotlight on Supportive Science and Basic Research | Poster

    Science.gov (United States)

    The lobby of Building 549 at NCI at Frederick bustled with activity for two hours on Tuesday, May 1, as several dozen scientists and staff gathered for the NCI Core Open House. The event aimed to encourage discussion and educate visitors about the capabilities of the cores, laboratories, and facilities that offer support to NCI’s Center for Cancer Research.

  10. Spotlight on necitumumab in the treatment of non-small-cell lung carcinoma

    Directory of Open Access Journals (Sweden)

    Thakur MK

    2017-02-01

    Full Text Available Manish K Thakur, Antoinette J Wozniak, Department of Oncology, Karmanos Cancer Center, Detroit, MI, USA Abstract: The treatment options for metastatic non-small-cell lung cancer (NSCLC have expanded dramatically in the last 10 years with the discovery of newer drugs and targeted therapy. Epidermal growth factor receptor (EGFR, when aberrantly activated, promotes cell growth and contributes in various ways to the malignant process. EGFR has become an important therapeutic target in a variety of malignancies. Small-molecule tyrosine kinase inhibitors (TKIs of EGFR are being used to treat advanced NSCLC and are particularly effective in the presence of EGFR mutations. Monoclonal antibodies have also been developed that block the EGFR at the cell surface and work in conjunction with chemotherapy. Necitumumab is a second-generation fully human IgG1 monoclonal antibody that has shown promise in metastatic NSCLC. The benefit has mostly been restricted to squamous cell lung cancer in the frontline setting. Considering that the survival advantage for these patients was modest, there is a need to discover biomarkers that will predict which patients will likely have the best outcomes. This review focuses on the development and clinical trial experience with necitumumab in NSCLC. Keywords: lung cancer, squamous cell, necitumumab, EGFR

  11. Range Sidelobe Response from the Use of Polyphase Signals in Spotlight Synthetic Aperture Radar

    Science.gov (United States)

    2015-12-01

    the requirements for the degree of MASTER OF SCIENCE IN ELECTRICAL ENGINEERING from the NAVAL POSTGRADUATE SCHOOL December 2015 Approved by...depicted in Figure 30. Figure 30. Top- Level Diagram of Radar Operation Adapted from [1]: M. Skolnik, Introduction to Radar Systems, 3rd ed., New York...Figure 37. Notional Synthetic Aperture Data Matrix In this chapter, we reviewed top- level radar concepts and generated the equations that describe

  12. Spotlight on taliglucerase alfa in the treatment of pediatric patients with type 1 Gaucher disease

    Directory of Open Access Journals (Sweden)

    Gupta P

    2017-06-01

    Full Text Available Punita Gupta,1 Gregory M Pastores2 1Division of Genetics, Department of Pediatrics, St. Joseph’s Children’s Hospital, Paterson, New Jersey, USA; 2National Center for Inherited Metabolic Disorders, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland Abstract: Gaucher disease (GD is a heritable storage disorder caused by functional defects of the lysosomal acid β-glucosidase and the accumulation of glucosylceramide within macrophages, resulting in multiple organ dysfunction. There are three commercially available enzyme replacement therapy (ERT products for the treatment of GD type 1 (GD1: imiglucerase, velaglucerase alfa, and taliglucerase alfa. Imiglucerase and velaglucerase alfa are produced in different mammalian cell systems; imiglucerase requires postproduction deglycosylation to expose terminal α-mannose residues, which are required for mannose receptor-mediated uptake by target macrophages. These steps are critical to the success of ERT for the treatment of visceral and hematologic manifestations of GD. Taliglucerase alfa is the first US Food and Drug Administration-approved plant-cell-expressed recombinant human protein, using carrot root cell cultures. Furthermore, it does not require postproduction glycosidic modifications. It is indicated for treatment of adults with GD1 in the US, Israel, Australia, Canada, Chile, Brazil, and other countries, and it is additionally approved for the treatment of pediatric patients in the US, Australia, and Canada and for the treatment of hematologic manifestations in pediatric patients with Type 3 GD in Canada and other countries. Our review focuses on the role of taliglucerase alfa in the pediatric population. A literature search through PubMed (from 1995 up till November 2016 of English language articles was performed with the following terms: Gaucher disease, lysosomal storage disease, taliglucerase. Secondary and tertiary references were obtained by reviewing related articles as well as the website www.Clinicaltrials.gov. It has been demonstrated that taliglucerase alfa is efficacious, with a well-established safety profile in pediatric, ERT-naïve patients with symptomatic GD1, as well as for those patients previously treated with imiglucerase. Keywords: Gaucher disease, enzyme replacement therapy, taliglucerase alfa, pediatrics

  13. Sunlight in the Spotlight in the International Year of Light (Poster abstract)

    Science.gov (United States)

    Larsen, K.

    2015-12-01

    (Abstract only) One of the main focuses of the International Year of Light (IYL) is interdisciplinary education and outreach. While variable stars in general provide myriad opportunities to accomplish this, one variable star in particular—our sun—offers unique opportunities in this vein. From conducting ground-based safe solar observations with white light and hydrogen alpha filters, to highlighting satellite observations at other wavelengths and spectroscopy, observing our nearest star provides a solid basis from which to explore the electromagnetic spectrum (and the relevant technologies used to study it). The IYL highlights cultural astronomy, the history of science, and the important role women have played in our understanding of the natural world. Not only was the primary deity in many cultures the sun god or goddess, but the motions of the sun across the heavens were carefully studied using sundials, astrolabes, and monolithic structures (including Stonehenge). Sunspots were discovered long before the invention of the telescope, and their occurrences carefully recorded. Today, these records (along with records of another important way the sun interacts with our planet, namely the creation of aurora) extend our understanding of the solar cycle backwards in time across the centuries to before the time of Galileo. Women have played an important role in our observation and understanding of the sun, including Annie Maunder at the Royal Greenwich Observatory and Elizabeth Brown, Solar Section Director of the British Astronomical Association. The sun also played a central role in verifying Einstein's General Theory of Relativity (itself celebrating its centenary during the IYL). This poster will provide examples of sun-centered projects and activities that can be used during the IYL and beyond to educate and interest citizens young and old about our nearest star, with an eye to especially highlighting the importance of the ongoing work of the Solar Section of the AAVSO.

  14. Italy on the spotlight: Expo Milan 2015 and Italian Journal of Food Science

    Directory of Open Access Journals (Sweden)

    P. Fantozzi

    2015-12-01

    Full Text Available The year 2015 will certainly be remembered as the Year of the Universal Exposition (EXPO hosted in Milan, Italy, focusing on a hot theme in the current scenario: “Feeding the Planet, Energyfor Life”.This event has drawn a wide international attention towards Italy as a country with peculiar and valuable food traditions, thus strengthening its reputation as “gastronomic capital of theworld” rich in protected designation of origin products (PDOs and characterised by a longstanding food culture.

  15. E-dictionary Use under the Spotlight: Students' Use of Pocket ...

    African Journals Online (AJOL)

    This article reports on the utilisation of pocket electronic dictionaries (PEDs) for writing by learners of English at a Thai university. It aims to enrich the study of dictionary use behaviour by investigating, through the use of combined research methods, exactly what happens when students use PEDs for production.

  16. Cognitive factors shape brain networks for auditory skills: spotlight on auditory working memory

    Science.gov (United States)

    Kraus, Nina; Strait, Dana; Parbery-Clark, Alexandra

    2012-01-01

    Musicians benefit from real-life advantages such as a greater ability to hear speech in noise and to remember sounds, although the biological mechanisms driving such advantages remain undetermined. Furthermore, the extent to which these advantages are a consequence of musical training or innate characteristics that predispose a given individual to pursue music training is often debated. Here, we examine biological underpinnings of musicians’ auditory advantages and the mediating role of auditory working memory. Results from our laboratory are presented within a framework that emphasizes auditory working memory as a major factor in the neural processing of sound. Within this framework, we provide evidence for music training as a contributing source of these abilities. PMID:22524346

  17. Inclusive education: A transformation and human rights agenda under spotlight in South Africa.

    Science.gov (United States)

    Maguvhe, Mbulaheni

    2015-01-01

    This study investigated the progress made in the implementation of inclusive education as a transformation and human rights tool since its inception in 2001. The study was conducted upon realising that most people underestimate the transformation and human rights value that inclusive education strives to maintain. The total number of participants interviewed was 84. Data was collected using semi-structured interview schedules for the teachers and community members, whereafter it was presented in thematic sections and qualitatively examined for meaning. The results showed that participants comprising teachers and community members do not know or understand the transformational and human rights value of inclusive education. The participants seemed to be equally aware of inclusive education, but they rated its success and value differently. The participants concurred that the philosophy of inclusive education was noble, but they differed regarding the extent to which it had transformed, added value or played an advocacy role in the lives of learners and the community at large over the years.

  18. "This one is stronger" : Spotlights on the lifelong learning professional-in-action

    NARCIS (Netherlands)

    van der Linden, Josje

    2016-01-01

    Om te kunnen omgaan met de veranderende realiteit in leven en werk, wordt wereldwijd een leven lang leren aangemoedigd. Het vierde duurzame ontwikkelingsdoel, vastgesteld in september 2015, weerspiegelt dit: “het verzekeren van kwalitatief goed onderwijs en het bevorderen van de mogelijkheden om een

  19. A Well-Maintained Lab Is a Safer Lab. Safety Spotlight

    Science.gov (United States)

    Walls, William H.; Strimel, Greg J.

    2018-01-01

    Administration and funding can cause Engineering/Technology Education (ETE) programs to thrive or die. To administrators, the production/prototyping equipment and laboratory setting are often viewed as the features that set ETE apart from other school subjects. A lab is a unique gift as well as a responsibility. If an administrator can see that…

  20. Physical Environmental Correlates of Domain-Specific Sedentary Behaviours across Five European Regions (the SPOTLIGHT Project).

    Science.gov (United States)

    Compernolle, Sofie; De Cocker, Katrien; Roda, Célina; Oppert, Jean-Michel; Mackenbach, Joreintje D; Lakerveld, Jeroen; Glonti, Ketevan; Bardos, Helga; Rutter, Harry; Cardon, Greet; De Bourdeaudhuij, Ilse

    2016-01-01

    The relation between neighbourhood environmental factors and domain-specific sedentary behaviours among adults remains unclear. This study firstly aims to examine the association of perceived and objectively measured neighbourhood safety, aesthetics, destinations and functionality with transport-related, work-related and leisure-time sedentary behaviour. Secondly, the study aims to assess whether these associations are moderated by age, gender or educational level. In 60 randomly sampled neighbourhoods from 5 urban regions in Europe (Ghent and suburbs, Paris and inner suburbs, Budapest and suburbs, the Randstad, and Greater London), a virtual audit with Google Street View was performed to assess environmental characteristics. A total of 5,205 adult inhabitants of these neighbourhoods reported socio-demographic characteristics, sedentary behaviours, and neighbourhood perceptions in an online survey. Generalized linear mixed models were conducted to examine associations between physical environmental neighbourhood factors and sedentary behaviours. Interaction terms were added to test the moderating role of individual-level socio-demographic variables. Lower levels of leisure-time sedentary behaviour (i.e. all leisure activities except television viewing and computer use) were observed among adults who perceived greater numbers of destinations such as supermarkets, recreational facilities, or restaurants in their neighbourhood, and among adults who lived in a neighbourhood with more objectively measured aesthetic features, such as trees, water areas or public parks. Lower levels of work-related sedentary behaviour were observed among adults who perceived less aesthetic features in their neighbourhood, and among adults who lived in a neighbourhood with less objectively measured destinations. Both age, gender and educational level moderated the associations between neighbourhood environmental factors and sedentary behaviours. Preliminary evidence was found for associations between neighbourhood environmental factors and domain-specific sedentary behaviours among adults. However, these associations varied according to objective or subjective environmental measures. More research is needed to confirm and clarify the associations.

  1. Serbian gas sector in the spotlight of oil and gas agreement with Russia

    International Nuclear Information System (INIS)

    Brkic, Dejan

    2009-01-01

    The Russian natural gas industry is the world's largest producer and transporter of natural gas. This paper identifies the benefits for Serbia as transient country to European Union for Russian natural gas through South Stream gas-line in the current political context of implementation of gas agreement. On the other hand, according to the Agreement on Stabilization and Integration to European Union, Serbia is obligatory to implement reforms in energy sector and its energy policy must be in accordance with the European Union policy. Republic of Serbia has produced and consumed natural gas domestically since 1952, but has always been net importer. Strategy of Energy Development in Serbia and especially, National Action Plan for the gasification on the territory of Republic of Serbia dedicated special attention to gas economy development in respect with expected contribution in efficient energy use and environmental policy protection in the country.

  2. Inclusive education: A transformation and human rights agenda under spotlight in South Africa

    Science.gov (United States)

    2015-01-01

    This study investigated the progress made in the implementation of inclusive education as a transformation and human rights tool since its inception in 2001. The study was conducted upon realising that most people underestimate the transformation and human rights value that inclusive education strives to maintain. The total number of participants interviewed was 84. Data was collected using semi-structured interview schedules for the teachers and community members, whereafter it was presented in thematic sections and qualitatively examined for meaning. The results showed that participants comprising teachers and community members do not know or understand the transformational and human rights value of inclusive education. The participants seemed to be equally aware of inclusive education, but they rated its success and value differently. The participants concurred that the philosophy of inclusive education was noble, but they differed regarding the extent to which it had transformed, added value or played an advocacy role in the lives of learners and the community at large over the years. PMID:28730034

  3. Ocular gene transfer in the spotlight: implications of newspaper content for clinical communications.

    Science.gov (United States)

    Benjaminy, Shelly; Bubela, Tania

    2014-07-16

    Ocular gene transfer clinical trials are raising hopes for blindness treatments and attracting media attention. News media provide an accessible health information source for patients and the public, but are often criticized for overemphasizing benefits and underplaying risks of novel biomedical interventions. Overly optimistic portrayals of unproven interventions may influence public and patient expectations; the latter may cause patients to downplay risks and over-emphasize benefits, with implications for informed consent for clinical trials. We analyze the news media communications landscape about ocular gene transfer and make recommendations for improving communications between clinicians and potential trial participants in light of media coverage. We analyzed leading newspaper articles about ocular gene transfer (1990-2012) from United States (n = 55), Canada (n = 26), and United Kingdom (n = 77) from Factiva and Canadian Newsstand databases using pre-defined coding categories. We evaluated the content of newspaper articles about ocular gene transfer for hereditary retinopathies, exploring representations of framing techniques, research design, risks/benefits, and translational timelines. The dominant frame in 61% of stories was a celebration of progress, followed by human-interest in 30% of stories. Missing from the positive frames were explanations of research design; articles conflated clinical research with treatment. Conflicts-of-interest and funding sources were similarly omitted. Attention was directed to the benefits of gene transfer, while risks were only reported in 43% of articles. A range of visual outcomes was described from slowing vision loss to cure, but the latter was the most frequently represented even though it is clinically infeasible. Despite the prominence of visual benefit portrayals, 87% of the articles failed to provide timelines for the commencement of clinical trials or for clinical implementation. Our analysis confirms that despite many initiatives to improve media communications about experimental biotechnologies, media coverage remains overly optimistic and omits important information. In light of these findings, our recommendations focus on the need for clinicians account for media coverage in their communications with patients, especially in the context of clinical trial enrolment. The development of evidence-based communication strategies will facilitate informed consent and promote the ethical translation of this biotechnology.

  4. Spotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date

    Directory of Open Access Journals (Sweden)

    Lazzerini PE

    2016-09-01

    Full Text Available Pietro Enea Lazzerini,1 Pier Leopoldo Capecchi,1 Giacomo Maria Guidelli,1 Enrico Selvi,1 Maurizio Acampa,2 Franco Laghi-Pasini1 1Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 2Stroke Unit, University Hospital of Siena, Siena, Italy Abstract: Rheumatoid arthritis (RA is a chronic autoimmune inflammatory disease primarily affecting synovial joints and is characterized by persistent high-grade systemic inflammation. Proinflammatory cytokines, particularly interleukin-6 (IL-6, are of crucial importance in the pathogenesis of the disease, driving both joint inflammation and extra-articular comorbidities. Tocilizumab, a humanized IL-6 receptor-inhibiting monoclonal antibody, has been the first, and, to date, the only, IL-6 inhibitor approved for the treatment of RA. Many studies have demonstrated the potency and effectiveness of tocilizumab in controlling disease activity and radiological progression of RA. These successful results have encouraged the development of novel IL-6 inhibitors, among which a promising agent is sirukumab (SRK, a human anti-IL-6 monoclonal antibody currently under evaluation in Phase II/III studies in patients with RA, systemic lupus erythematosus, giant-cell arteritis, and major depressive disorder. The evidence to date indicates SRK as an effective and well-tolerated new therapeutic tool for patients with active RA, with some preliminary data suggesting a specific beneficial impact on relevant systemic complications associated with the disease, such as depression and cardiovascular disease. Conversely, although pathophysiological considerations make plausible the hypothesis that IL-6 blockade with SRK may also be beneficial in the treatment of many diseases other than RA (either autoimmune or not, available clinical data in patients with systemic lupus erythematosus do not seem to support this view, also giving rise to potentially relevant concerns about drug safety. If large Phase III clinical trials currently in progress in patients with RA confirm the efficacy and tolerability of SRK, then in the long term, this drug could, in the near future, occupy a place in the treatment of the disease, potentially also opening the doors to a more extended use of SRK in a wide range of disorders in which IL-6 plays a key pathogenic role. Keywords: sirukumab, rheumatoid arthritis, interleukin-6, tocilizumab, systemic lupus erythematosus, cardiovascular disease, interleukin-6

  5. Putting urban soils in the spotlight: A learning experience through the Climate-KIC's initiative

    Science.gov (United States)

    Maymó, Ana; Gimeno-García, Eugenia; Pascual-Aguilar, Juan Antonio; Andreu, Vicente; Rubio, José Luis

    2015-04-01

    The European Commission encourages integrating ecosystem-based approaches in the portfolio of adaptation strategies also in the urban areas. However, the renewed interest in the environmental benefits from green infrastructures coexists with the marginality with which they are treated in practice and, especially, where soil is concerned. Despite its critical functions, soils in cities have often been neglected. In fact, urban soil issues rarely get society attention or even from our policy makers. But, how to make urban soils visible?. From academia we need to extend our communication and networking abilities to engage citizens with projects related to urban soils. Through the Climate-KIC's professional placement programme, Pioneers into Practice, we were able to connect with stakeholders with widely different interests, and engage a broad range of opinions and comments on local circumstances and needs in a semi-quantitative form. Methodology included an actor analysis, an actor network map and a set of semi-structured actor interviews. This involved a local stakeholder network establishment. This stakeholder network reaches out beyond the usual suspects we would expect to partner and it is represented by the following groups: local administration, local governmental services (e.g., forestry and agriculture extension), relevant non-governmental organizations (e.g., dedicated to environment or development) at local level, planners, developers, and individuals (e.g., long-term local residents). The approach is focused on the non-technical barriers to success, whether they are social, institutional, financial, behavioral or regulatory, and how to overcome them. In this context, of a raising environmental awareness, the principal response from interviews demonstrated strong support for a strategic approach to soil management at the urban core and the countryside fringe. Herein, the contribution of urban soils to the provision of ecosystem services, in the framework of the Payments for Ecosystem Services (PES), aroused a great deal of interest among the different stakeholders interviewed. However, the low level of community awareness and understanding of threats to soil natural capital and the long-term consequences of this were also recognized.

  6. World No Tobacco Day 2002 puts spotlight on tobacco-free sports

    Directory of Open Access Journals (Sweden)

    2002-01-01

    Full Text Available El Día Mundial sin Tabaco se celebra en todo el mundo el 31 de mayo. Los Estados Miembros de la Organización Mundial de la Salud (OMS crearon el Día Mundial sin Tabaco en 1987 con el fin de llamar la atención del mundo entero a la epidemia de tabaquismo y a las enfermedades y muertes prevenibles que el tabaquismo causa. Mediante esta celebración anual se le proporciona al público información sobre los peligros de consumir productos del tabaco; las prácticas comerciales de la compañias tabacaleras; lo que están haciendo la OMS y sus Oficinas Regionales, entre ellas la Organización Panamericana de la Salud (OPS, para combatir la epidemia de tabaquismo; y lo que pueden hacer las personas en cualquier parte para hacer valer su derecho a la vida y a vivir sanamente y para proteger a las generaciones futuras. La celebración en 2002 del Día Mundial sin Tabaco se centra específicamente en las prácticas de mercadeo de la industria del tabaco y cómo esta aprovecha a los atletas y los acontecimientos deportivos para vender sus productos. Este artículo resume el contenido de un folleto especial preparado por la OMS para proveer información sobre el Día Mundial sin Tabaco y el tema central de este año, que es eliminar el tabaco del mudno del deporte.

  7. World No Tobacco Day 2002 puts spotlight on tobacco-free sports

    Directory of Open Access Journals (Sweden)

    2002-04-01

    Full Text Available El Día Mundial sin Tabaco se celebra en todo el mundo el 31 de mayo. Los Estados Miembros de la Organización Mundial de la Salud (OMS crearon el Día Mundial sin Tabaco en 1987 con el fin de llamar la atención del mundo entero a la epidemia de tabaquismo y a las enfermedades y muertes prevenibles que el tabaquismo causa. Mediante esta celebración anual se le proporciona al público información sobre los peligros de consumir productos del tabaco; las prácticas comerciales de la compañias tabacaleras; lo que están haciendo la OMS y sus Oficinas Regionales, entre ellas la Organización Panamericana de la Salud (OPS, para combatir la epidemia de tabaquismo; y lo que pueden hacer las personas en cualquier parte para hacer valer su derecho a la vida y a vivir sanamente y para proteger a las generaciones futuras. La celebración en 2002 del Día Mundial sin Tabaco se centra específicamente en las prácticas de mercadeo de la industria del tabaco y cómo esta aprovecha a los atletas y los acontecimientos deportivos para vender sus productos. Este artículo resume el contenido de un folleto especial preparado por la OMS para proveer información sobre el Día Mundial sin Tabaco y el tema central de este año, que es eliminar el tabaco del mudno del deporte.

  8. Lifestyle correlates of overweight in adults: a hierarchical approach (the SPOTLIGHT project)

    NARCIS (Netherlands)

    Roda, C.; Charreire, H.; Feuillet, T.; Mackenbach, J.D.; Compernolle, S.; Glonti, K.; Bárdos, H.; Rutter, H.; McKee, M.; Brug, J.; De Bourdeaudhuij, I.; Lakerveld, J.; Oppert, J.-M.

    2016-01-01

    Background Obesity-related lifestyle behaviors usually co-exist but few studies have examined their simultaneous relation with body weight. This study aimed to identify the hierarchy of lifestyle-related behaviors associated with being overweight in adults, and to examine subgroups so identified.

  9. Physical Environmental Correlates of Domain-Specific Sedentary Behaviours across Five European Regions (the SPOTLIGHT Project.

    Directory of Open Access Journals (Sweden)

    Sofie Compernolle

    Full Text Available The relation between neighbourhood environmental factors and domain-specific sedentary behaviours among adults remains unclear. This study firstly aims to examine the association of perceived and objectively measured neighbourhood safety, aesthetics, destinations and functionality with transport-related, work-related and leisure-time sedentary behaviour. Secondly, the study aims to assess whether these associations are moderated by age, gender or educational level.In 60 randomly sampled neighbourhoods from 5 urban regions in Europe (Ghent and suburbs, Paris and inner suburbs, Budapest and suburbs, the Randstad, and Greater London, a virtual audit with Google Street View was performed to assess environmental characteristics. A total of 5,205 adult inhabitants of these neighbourhoods reported socio-demographic characteristics, sedentary behaviours, and neighbourhood perceptions in an online survey. Generalized linear mixed models were conducted to examine associations between physical environmental neighbourhood factors and sedentary behaviours. Interaction terms were added to test the moderating role of individual-level socio-demographic variables.Lower levels of leisure-time sedentary behaviour (i.e. all leisure activities except television viewing and computer use were observed among adults who perceived greater numbers of destinations such as supermarkets, recreational facilities, or restaurants in their neighbourhood, and among adults who lived in a neighbourhood with more objectively measured aesthetic features, such as trees, water areas or public parks. Lower levels of work-related sedentary behaviour were observed among adults who perceived less aesthetic features in their neighbourhood, and among adults who lived in a neighbourhood with less objectively measured destinations. Both age, gender and educational level moderated the associations between neighbourhood environmental factors and sedentary behaviours.Preliminary evidence was found for associations between neighbourhood environmental factors and domain-specific sedentary behaviours among adults. However, these associations varied according to objective or subjective environmental measures. More research is needed to confirm and clarify the associations.

  10. Sharing the spotlight in Durban: A report from IAS TB2016 at AIDS2016

    Directory of Open Access Journals (Sweden)

    J.A. Whitaker

    2017-05-01

    Full Text Available Tuberculosis (TB is now recognized as the number one cause of death worldwide due to a single infectious pathogen and is the cause of death in one-third of people living with HIV worldwide. An inaugural pre-conference focused on TB (TB2016 was held at the International AIDS Society Conference AIDS2016. This report focuses on key messages from the TB2016 conference that are important for the medical, public health, activist, and scientific communities. Keywords: Tuberculosis, HIV, Epidemiology, Public health, Treatment, Prevention

  11. Obesity in Children and the 'Myth of Psychological Maladjustment': Self-Esteem in the Spotlight.

    Science.gov (United States)

    Hill, Andrew J

    2017-03-01

    There are contrasting views regarding the psychological well-being of children with obesity. Responding to limitations of existing evidence, Jane Wardle in 2005 argued for a 'myth of psychological maladjustment'. This review looks again at self-esteem. The different characterisations of self-esteem each offer value. Global self-esteem is reduced in nearly all studies of youth with obesity. Dimensional self-esteem reveals physical appearance, athletic and social competence as the most affected areas, confirmed by research that has operationalised low self-competence. Children with obesity are also more likely to be victimised by their peers, generally and for their fatness. Victims who bully others appear to preserve some aspects of self-esteem. A relatively small proportion of youth with obesity has low self-esteem, but those with severe and persistent obesity are especially compromised. Weight loss is only weakly associated with improved self-competence suggesting the value of resilience and asset approaches to improving well-being.

  12. Spotlight on Speech Codes 2011: The State of Free Speech on Our Nation's Campuses

    Science.gov (United States)

    Foundation for Individual Rights in Education (NJ1), 2011

    2011-01-01

    Each year, the Foundation for Individual Rights in Education (FIRE) conducts a rigorous survey of restrictions on speech at America's colleges and universities. The survey and accompanying report explore the extent to which schools are meeting their legal and moral obligations to uphold students' and faculty members' rights to freedom of speech,…

  13. Spotlight on Speech Codes 2009: The State of Free Speech on Our Nation's Campuses

    Science.gov (United States)

    Foundation for Individual Rights in Education (NJ1), 2009

    2009-01-01

    Each year, the Foundation for Individual Rights in Education (FIRE) conducts a wide, detailed survey of restrictions on speech at America's colleges and universities. The survey and resulting report explore the extent to which schools are meeting their obligations to uphold students' and faculty members' rights to freedom of speech, freedom of…

  14. Spotlight on Speech Codes 2010: The State of Free Speech on Our Nation's Campuses

    Science.gov (United States)

    Foundation for Individual Rights in Education (NJ1), 2010

    2010-01-01

    Each year, the Foundation for Individual Rights in Education (FIRE) conducts a rigorous survey of restrictions on speech at America's colleges and universities. The survey and resulting report explore the extent to which schools are meeting their legal and moral obligations to uphold students' and faculty members' rights to freedom of speech,…

  15. Ultraviolet radiation and blue-light emissions from spotlights incorporating tungsten halogen lamps

    CERN Document Server

    MacKinlay, Alistair F; Whillock, M J

    1989-01-01

    This report summarises measurements of the ultraviolet radiation and blue-light emissions from eleven 'desk-top' tungsten halogen (quartz) lamps and one 'floor-standing' tungsten halogen (quartz) lamp available in the UK. Values of occupational hazard weighted and erythemally weighted ultraviolet radiation irradiance and measurements and relevant calculations of blue-light hazards are presented. It is concluded that the safety design of some desk-top tungsten halogen lamps is inadequate to prevent unnecessary exposure of the skin to potentially harmful ultraviolet radiation. It is recommended that all tungsten halogen lamps should have sufficient filtration to reduce their ultraviolet emissions to an acceptably low level. As long as the comfort aversion responses of the eye are respected, direct viewing of the lamps examined should not constitute a retinal hazard.

  16. Ultraviolet radiation and blue-light emissions from spotlights incorporating tungsten halogen lamps

    International Nuclear Information System (INIS)

    McKinlay, A.F.; Whillock, M.J.; Meulemans, C.C.E.

    1989-07-01

    This report summarises measurements of the ultraviolet radiation and blue-light emissions from eleven 'desk-top' tungsten halogen (quartz) lamps and one 'floor-standing' tungsten halogen (quartz) lamp available in the UK. Values of occupational hazard weighted and erythemally weighted ultraviolet radiation irradiance and measurements and relevant calculations of blue-light hazards are presented. It is concluded that the safety design of some desk-top tungsten halogen lamps is inadequate to prevent unnecessary exposure of the skin to potentially harmful ultraviolet radiation. It is recommended that all tungsten halogen lamps should have sufficient filtration to reduce their ultraviolet emissions to an acceptably low level. As long as the comfort aversion responses of the eye are respected, direct viewing of the lamps examined should not constitute a retinal hazard. (author)

  17. Spotlight back on LHW with Yucca Mountain on Trump's horizon

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, St George' s Redditch (United Kingdom)

    2017-08-15

    After years of argument and delay could the US be edging closer to resurrecting proposals to build a national repository for high level nuclear waste (HLW) at Yucca Mountain in Nevada? The federal government has looked at the site with a view to establishing a repository since the 1970s. However, after pouring billions of dollars into projects and studies over the decades, the project remained bogged down in legal battles and opposition from politicians and pressure groups. Now, the US Nuclear Regulatory Commission (NRC) said it had directed its staff to use the equivalent of about EUR 95,000 from the national Nuclear Waste Fund on ''information-gathering activities'' that could pave the way for resuming a licensing review of Yucca Mountain as a potential deep geologic repository (DGR).

  18. Using College Admission Test Scores to Clarify High School Placement. Leading Indicator Spotlight

    Science.gov (United States)

    Flug, Susanna

    2010-01-01

    In "Beyond Test Scores: Leading Indicators for Education," Foley and colleagues (2008) define leading indicators as those that "provide early signals of progress toward academic achievement" (p. 1) and stress that educators "need leading indicators to help them see the direction their efforts are going in and to take…

  19. Pre-Algebra and Algebra Enrollment and Achievement. Leading Indicator Spotlight

    Science.gov (United States)

    Musen, Lindsey

    2010-01-01

    In "Beyond Test Scores: Leading Indicators for Education," Foley and colleagues (2008) define "leading indicators" as those that "provide early signals of progress toward academic achievement" (p. 1) and stress that educators "need leading indicators to help them see the direction their efforts are going in and to take corrective action as soon as…

  20. Shedding light on inflammatory pseudotumor in children: spotlight on inflammatory myofibroblastic tumor

    Energy Technology Data Exchange (ETDEWEB)

    Lai, Lillian M.; Kao, Simon C.S.; Moritani, Toshio; Clark, Eve; Ishigami, Kousei; Sato, Yutaka [University of Iowa Hospitals and Clinics, Department of Radiology, Carver College of Medicine, Iowa City, IA (United States); McCarville, M.B. [St. Jude Children' s Research Hospital, Department of Radiology, Memphis, TN (United States); Kirby, Patricia [University of Iowa Hospitals and Clinics, Department of Pathology, Carver College of Medicine, Iowa City, IA (United States); Bahrami, Armita [St. Jude Children' s Research Hospital, Department of Pathology, Memphis, TN (United States)

    2015-11-15

    Inflammatory pseudotumor is a generic term used to designate a heterogeneous group of inflammatory mass-forming lesions histologically characterized by myofibroblastic proliferation with chronic inflammatory infiltrate. Inflammatory pseudotumor is multifactorial in etiology and generally benign, but it is often mistaken for malignancy given its aggressive appearance. It can occur throughout the body and is seen in all age groups. Inflammatory pseudotumor has been described in the literature by many organ-specific names, resulting in confusion. Recently within this generic category of inflammatory pseudotumor, inflammatory myofibroblastic tumor has emerged as a distinct entity and is now recognized as a fibroblastic/myofibroblastic neoplasm with intermediate biological potential and occurring mostly in children. We present interesting pediatric cases of inflammatory myofibroblastic tumors given this entity's tendency to occur in children. Familiarity and knowledge of the imaging features of inflammatory pseudotumor can help in making an accurate diagnosis, thereby avoiding unnecessary radical surgery. (orig.)

  1. Language at preschool in Europe: Early years professionals in the spotlight

    NARCIS (Netherlands)

    Michel, M.C.; Kuiken, F.

    2014-01-01

    Over the past few decades early years education throughout Europe has experienced many changes due to higher numbers of children attending centres for early childhood education and care (ECEC), a growing linguistic and cultural diversity in society and a shift from care to education with the focus

  2. Spotlight on fish: light pollution affects circadian rhythms of European perch but does not cause stress.

    Science.gov (United States)

    Brüning, Anika; Hölker, Franz; Franke, Steffen; Preuer, Torsten; Kloas, Werner

    2015-04-01

    Flora and fauna evolved under natural day and night cycles. However, natural light is now enhanced by artificial light at night, particularly in urban areas. This alteration of natural light environments during the night is hypothesised to alter biological rhythms in fish, by effecting night-time production of the hormone melatonin. Artificial light at night is also expected to increase the stress level of fish, resulting in higher cortisol production. In laboratory experiments, European perch (Perca fluviatilis) were exposed to four different light intensities during the night, 0 lx (control), 1 lx (potential light level in urban waters), 10 lx (typical street lighting at night) and 100 lx. Melatonin and cortisol concentrations were measured from water samples every 3h during a 24 hour period. This study revealed that the nocturnal increase in melatonin production was inhibited even at the lowest light level of 1 lx. However, cortisol levels did not differ between control and treatment illumination levels. We conclude that artificial light at night at very low intensities may disturb biological rhythms in fish since nocturnal light levels around 1 lx are already found in urban waters. However, enhanced stress induction could not be demonstrated. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. A spotlight on preschool: the influence of family factors on children's early literacy skills.

    Science.gov (United States)

    Heath, Steve M; Bishop, Dorothy V M; Bloor, Kimberley E; Boyle, Gemma L; Fletcher, Janet; Hogben, John H; Wigley, Charles A; Yeong, Stephanie H M

    2014-01-01

    Phonological awareness, letter knowledge, oral language (including sentence recall) and rapid automatised naming are acknowledged within-child predictors of literacy development. Separate research has identified family factors including socio-economic status, parents' level of education and family history. However, both approaches have left unexplained significant amounts of variance in literacy outcomes. This longitudinal study sought to improve prospective classification accuracy for young children at risk of literacy failure by adding two new family measures (parents' phonological awareness and parents' perceived self-efficacy), and then combining the within-child and family factors. Pre-literacy skills were measured in 102 four year olds (46 girls and 56 boys) at the beginning of Preschool, and then at the beginning and end of Kindergarten, when rapid automatised naming was also measured. Family factors data were collected at the beginning of Preschool, and children's literacy outcomes were measured at the end of Year 1 (age 6-7 years). Children from high-risk backgrounds showed poorer literacy outcomes than low-risk students, though three family factors (school socio-economic status, parents' phonological awareness, and family history) typically accounted for less Year 1 variance than the within-child factors. Combining these family factors with the end of Kindergarten within-child factors provided the most accurate classification (i.e., sensitivity = .85; specificity = .90; overall correct = .88). Our approach would identify at-risk children for intervention before they began to fail. Moreover, it would be cost-effective because although few at-risk children would be missed, allocation of unnecessary educational resources would be minimised.

  4. Lead Halide Perovskite Nanocrystals in the Research Spotlight: Stability and Defect Tolerance

    Science.gov (United States)

    2017-01-01

    This Perspective outlines basic structural and optical properties of lead halide perovskite colloidal nanocrystals, highlighting differences and similarities between them and conventional II–VI and III–V semiconductor quantum dots. A detailed insight into two important issues inherent to lead halide perovskite nanocrystals then follows, namely, the advantages of defect tolerance and the necessity to improve their stability in environmental conditions. The defect tolerance of lead halide perovskites offers an impetus to search for similar attributes in other related heavy metal-free compounds. We discuss the origins of the significantly blue-shifted emission from CsPbBr3 nanocrystals and the synthetic strategies toward fabrication of stable perovskite nanocrystal materials with emission in the red and infrared parts of the optical spectrum, which are related to fabrication of mixed cation compounds guided by Goldschmidt tolerance factor considerations. We conclude with the view on perspectives of use of the colloidal perovskite nanocrystals for applications in backlighting of liquid-crystal TV displays. PMID:28920080

  5. Grantee Spotlight: Marvella Ford, Ph.D. - Reducing Barriers to Surgical Cancer Care among African Am

    Science.gov (United States)

    Drs. Marvella E. Ford and Nestor F. Esnaola were awarded a five-year NIH/NIMHD R01 grant to evaluate a patient navigation intervention to reduce barriers to surgical cancer care and improving surgical resection rates in African Americans with lung cancer.

  6. Pharmacoeconomic spotlight on rotavirus vaccine RIX4414 (Rotarix™) in developed countries.

    Science.gov (United States)

    Plosker, Greg L

    2012-12-01

    The most common cause of severe diarrhea in infants and young children is rotavirus gastroenteritis (RVGE), which is associated with significant morbidity, healthcare resource use, and direct and indirect costs in industrialized nations. The monovalent rotavirus vaccine RIX4414 (Rotarix™) is administered as a two-dose oral series in infants and has demonstrated protective efficacy against RVGE in clinical trials conducted in developed countries. In addition, various naturalistic studies have demonstrated 'real-world' effectiveness after the introduction of widespread rotavirus vaccination programs in the community setting. Numerous cost-effectiveness analyses have been conducted in developed countries in which a universal rotavirus vaccination program using RIX4414 was compared with no universal rotavirus vaccination program. There was a high degree of variability in base-case results across studies even when the studies were conducted in the same country, often reflecting differences in the selection of data sources or assumptions used to populate the models. In addition, results were sensitive to plausible changes in a number of key input parameters. As such, it is not possible to definitively state whether a universal rotavirus vaccination program with RIX4414 is cost effective in developed countries, although results of some analyses in some countries suggest this is the case. In addition, international guidelines advocate universal vaccination of infants and children against rotavirus. It is also difficult to draw conclusions regarding the cost effectiveness of rotavirus vaccine RIX4414 relative to that of the pentavalent rotavirus vaccine, which is administered as a three-dose oral series. Although indirect comparisons in cost-effectiveness analyses indicate that RIX4414 provided more favorable incremental cost-effectiveness ratios when each vaccine was compared with no universal rotavirus vaccination program, results were generally sensitive to vaccine costs. Actual tender prices of a full vaccination course for each vaccine were not known at the time of the analyses and therefore had to be estimated.

  7. Proyecto de creación de una franquicia disensa en el cantón la libertad provincia de Santa Elena

    OpenAIRE

    Rosales, César; Robayo, Sixto; Valle, Jonathan

    2010-01-01

    The objective is to offer a wide range of products and services for construction, providing favorable purchase options to our customers. In this way, we deliver more products, individually or in packages at competitive costs and a personalized attention that allows us to assess their satisfaction. Continuing with the concept of total supply, the basket of products offered to our end users focuses on products for construction and other industrial products. You want to make this project to give...

  8. Sistema de monitoreo de embarcaciones de pesca artesanal de Anconcito, provincia de Santa Elena, Ecuador, utilizando tecnología AIS - Automatic Identification System

    Directory of Open Access Journals (Sweden)

    Ashley Avilés Bastidas

    2017-06-01

    Full Text Available Ante la evidente crisis que se está presentando en Ecuador debido al incremento en los índices de robos en altamar, principalmente de los motores fuera de borda de las lanchas de pesca artesanal, es necesario implementar un sistema de control eficaz que ofrezca seguridad para la comunidad pesquera; con este fin se propone un sistema de detección de embarcaciones de pesca artesanal con tecnología AIS. En este estudio se explican todos los beneficios que ofrece esta tecnología que actualmente se usa para el monitoreo de buques, así como las aplicaciones para un sistema de monitoreo de embarcaciones pequeñas, las clases de equipos disponibles y sus principales características. Con este objetivo se propone el diseño de una red que permita ubicar las embarcaciones de la comunidad pesquera de Anconcito, que es una de las zonas más afectadas por la delincuencia. Además, se anticipan los resultados esperados con este diseño y varias alternativas técnicas para mejorar la cobertura del sistema. Abstract Given the evident crisis that is occurring in Ecuador due to the increase in the rates of robberies on the high seas, mainly of the outboard motorboats of the artisanal fishing boats, it is necessary to implement an effective control system that provides security for the fishing community. To this end, a system of detection of artisanal fishing vessels with AIS technology is proposed. In this study, all the benefits of this technology are explained which is currently used for monitoring ships, as well as the applications for a monitoring system of small boats, the kinds of equipment available and their main characteristics. With this objective, the design of a network that allows locate the vessels of the fishing community of Anconcito, which is one of the areas most affected by crime, is proposed. In addition, the expected results with this design and several technical alternatives to improve the coverage of the system are anticipated.

  9. Chromium in surface water and groundwater in the surrounding area of a tannery: relationships with water quality baseline, Elena, Cordoba. Argentina

    International Nuclear Information System (INIS)

    Matteoda, E.; Blarasin, M.; Damilano, G.; Cabrera, A.; Giuliano Albo, J.

    2009-01-01

    The basin of the El Barreal stream is a dominantly rural area in which groundwater is used for all activities whereas the stream is used as sink of residues and effluents. The existence of a tannery, which discharge the effluents into a wetland (which is drained by the stream), reveals the need to study the presence of Chromium in surface and groundwater and to compare values derived from pollution with those corresponding to the natural water baseline values. Fifty three samples of surface and groundwater were abstracted and chemical analyses were made, including total Chromium in water and plants. The chemical analysis results were studied by means of conventional and statistical techniques. The local and regional geological characteristics allow us to interpret that Chromium in water is derived from source minerals, being possible to stand out that high values probably are related to nearby serpentinite bodies.The values of total chrome in surface and groundwater are included in the natural quality baseline range calculated for this basin (0,25-5ug/L), exempting those samples with higher values linked to sites with farming activities and to the wetland environment where the Chromium effluent is discharged. In the last place, Chromium was retained in soil and plants whereas the aquifer was affected by a contaminant plume of total dissolved solids because of advective-dispersive transport. In the 2009 monitoring survey, a small increase of Chromium in groundwater was detected in relation to that of 2005, being assumed that partial desorption of Chromium is taking place from the solid phase. (Author) 19 refs.

  10. Proyecto de producción de sandia para exportación en la península de Santa Elena

    OpenAIRE

    Alban Wong, Gina; Arnao Franco, Carmen; Mejia Coronel, Marco Tulio

    2009-01-01

    Según datos proporcionados por el Tercer Censo Agropecuario, en el Ecuador se sembraron 1.905 ha. de sandía como monocultivo, en 1.788 unidades de producción agropecuarias (UPAs.). La producción fue de 25.818 toneladas. Además, se sembraron las 363 ha de sandía en cultivos asociados que produjeron 273 t. La siembra de sandía en el Ecuador es desde mayo hasta octubre y se han presentado exportaciones entre los meses de septiembre y diciembre. La cosecha de sandía en el mercado interno...

  11. Utilización de neumáticos usados como agregado en el hormigón: caso provincia de Santa Elena, Ecuador

    Directory of Open Access Journals (Sweden)

    Armando Saltos

    2017-06-01

    Full Text Available El proyecto encontró un diseño de hormigón con partículas provenientes de neumáticos usados, que después de un proceso de selección, trituración controlada, una dosificación acorde con los parámetros de las normas internacionales de diseño de hormigón del Instituto Americano del Concreto (ACI, la Norma Ecuatoriana de Construcción (NEC, la incorporación de hasta 10 % de caucho triturado como sustituto parcial de agregados gruesos en el diseño de hormigón, se obtienen resultados favorables y de buena resistencia lo que hace que  se pueda utilizar cumpliendo todas las normas ecuatorianas de la construcción. También se realizó un ensayo con un 10% de caucho triturado incorporado como sustituto parcial del agregado fino, resultando ser aún más apropiado para fines constructivos y de elaboración de hormigón. En el presente trabajo de investigación se realiza los ensayos como mezclas separadas. Se efectuaron pruebas de vigas con incorporación de agregados gruesos de hasta 15% cumpliendo las normas, pero no se ejecutó una serie completa. Palabras clave: neumático, agregado, hormigón, resistencia. Abstract The project found a concrete design with particles from used tires, which after a selection process, controlled grinding, a dosage in accordance with the parameters of the American Concrete Institute (ICA international standards of concrete design, Standard (NEC, the incorporation of up to 10% of tired rubber as a partial substitute of coarse aggregates in the concrete design, gives favorable results and good resistance which makes it possible to use all the Ecuadorian standards of the building. A test with 10% of crushed rubber incorporated as a partial substitute of the fine aggregate was also performed, making it even more suitable for construction and concrete processing purposes. In the present research work the tests are performed as separate mixtures. Beams were tested with incorporation of coarse aggregates of up to 15% complying with the standards, but a complete series was not performed. Keywords: Tire, aggregate, concrete, resistance.

  12. JUDENSNAIDER, Elena; LIMA, Luciana; ORTELLADO, Pablo; POMAR, Marcelo. Vinte centavos: a luta contra o aumento. São Paulo: Editora Veneta, 2013.

    Directory of Open Access Journals (Sweden)

    Isabel Loureiro

    2014-10-01

    Full Text Available 20 centavos: a luta contra o aumento, diferentemente das publicações voltadas à análise pura e simples dos acontecimentos, dedica-se a um relato dos embates políticos diários em São Paulo, a partir de documentos, lembranças dos participantes e entrevistas com os principais protagonistas – Movimento Passe Livre (MPL, prefeitura [PT] e governo do Estado de São Paulo [PSDB], polícia militar, meios de comunicação, PT, poder legislativo. A narrativa começa no dia 6 de junho e termina no dia 19, quando é anunciada a redução da tarifa.

  13. The ELENA Programme in the Province of Chieti - A Public Private Partnership Best Practice Improving Energy Efficiency of Buildings and Public Lighting Systems

    Directory of Open Access Journals (Sweden)

    Pierluigi Fecondo

    2015-09-01

    To date, the most relevant Project outcomes consist 87 municipalities involved, a structured database of energy audit and data about 144 buildings and about 46,000 public light points. Moreover, an effective engagement of public and private stakeholders, lays the foundation for a strong Energy Performance Contract framework able to leverage financing based on minimun guaranteed energy savings of 20% in respect to baseline values.

  14. A new species of poeciliid fish, Poeciliopsis santaelena, from Peninsula Santa Elena, Area de Conservación Guanacaste, Costa Rica

    Directory of Open Access Journals (Sweden)

    William A Bussing

    2008-06-01

    Full Text Available An undescribed freshwater fish was recently discovered during a biological inventory of Area de Conservación Guanacaste, northwestern Costa Rica. This new species of Poeciliopsis is closely related to a group of widespread species of small spotted fishes designated as the Poeciliopsis gracilis complex in this study. The complex extends on both versants from southern Mexico to Nicaragua, and with this new finding, extends into Costa Rica. The new species is distinguished from its Central American relatives by its lack of lateral and ventral markings, higher pectoral and caudal-fin counts and more posterior placement of the dorsal fin. Poeciliopsis santaelena is endemic to the Río Potrero Grande, a river whose flow is reduced to just a few pools during the long dry season and flows fully only during very rainy weather. It is just another in a growing list of threatened or endangered species found in this unique peninsular environment. Rev. Biol. Trop. 56 (2: 829-838. Epub 2008 June 30.Recientemente se descubrió una especie no descrita de pez dulceacuícola durante un inventario biológico en Area de Conservación Guanacaste (ACG en el noroeste de Costa Rica. Esta especie nueva del género Poeciliopsis tiene un parentesco cercano con un grupo de especies con puntos en los costados ampliamente distribuidas que se designan en este informe como complejo de Poeciliopsis gracilis. El complejo se extiende en ambas vertientes desde el sur de México hasta Nicaragua. La especie nueva se distingue de sus parientes centroamericanos por su falta de manchas negras laterales y ventrales, mayor número de radios pectorales y caudales, y posición más posterior de la aleta dorsal. Poeciliopsis santaelena, especie endémica de un sólo riachuelo intermitente, es una especie más in la lista de especies en peligro que se encuentra en este peculiar ambiente peninsular.

  15. INCIDENCIA DE LA INVESTIGACION BIBLIOGRAFICA EN EL APRENDIZAJE EN ESTUDIANTES DEL NIVEL BÁSICO DE LA CARRERA ADMINISTRACION DE EMPRESAS DE UNIVERSIDAD ESTATAL PENINSULA DE SANTA ELENA

    Directory of Open Access Journals (Sweden)

    William Caiche

    2016-04-01

    Full Text Available El desarrollo de Hábitos de lectura en estudiantes de educacion superior represent un verdadero reto para el docente, sobre todo porque dicha práctica impulsa la capacidad de analizar y de emitir juicios de valor y consolida las bases cognitivas que recibe en el proceso de aprendizaje, se ha identificado que, el estudiante de Administracion de empresas en el desarrollo de actividades academicas cita referencias bibliograficas que, de manera mayoritaria proviene de consultas de bajo nivel academico, por otro lado, es escaso el numero de referencias que incluyen, esta situacion limita el aprendizaje, y se reflejan en los resultadops de evaluacion del proceso. Este trabajo plantea como objetivo determinar el efecto que tiene en el aprendizaje la implementacion de una guia de investigacion bibliografica paa el nivel basico en los estudiantes de Carrera de Administracion de Empresas de la UPSE; para el efecto se recurre a un diseño de investigacion explicativo que a traves de la compracion del antes y el despues permita verificar el logro de tal objetivo.

  16. Elena de Miguel, Azucena Palacios y Ana Serradilla (eds.) Estructuras Léxicas y Estructura del Léxico, Peter Lang, 2006. 367 p

    DEFF Research Database (Denmark)

    Vinther, Thora

    2008-01-01

    Anmeldelse af en samling artikler der inddrager studiet af ord og ordsammensætninger med mange forskellige tilgange, herunder semantiske og kognitive principper, kontrastivt eller diakront udgangspunkt....

  17. Detección de compuestos presentes en una especie de Amanita micoparasitada, colectada en el corregimiento de Santa Elena (Antioquia, Colombia)

    OpenAIRE

    Aura Helena Corredor Q.; Liliana Londoño

    2005-01-01

    Para este trabajo se seleccionó una especie de Amanita, parasitada probablemente por un Hyphomycete, que presenta un crecimiento anormal y sobre la cual no existen trabajos previos. Inicialmente se hicieron extracciones etanólicas del material fresco en frío y con soxhlet. Se realizó una marcha fotoquímica preliminar del extracto obtenido y se detectaron coumarinas, alcaloides, fenoles y glicósidos cardiotónicos. Posteriormente se estandarizó que la cromatografía de capa fina con el sistem...

  18. Posibilidades de Generación de Energía en base al Potencial Geotérmico de la Península de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Hernán E. Poveda Z.

    2015-10-01

    En este estudio, proponemos la posibilidad de utilizar esta energía natural para transformarla en electricidad. Aprovechando las condiciones de algunos de los afloramientos de manantiales de agua caliente y volcanes de lodo que existen en la provincia. Para lo cual hemos propuesto al Instituto Austriaco de tecnología, su asesoría y asistencia para proponer un proyecto al ministerio de electrificación y energías renovables.

  19. Chromium in surface water and groundwater in the surrounding area of a tannery: relationships with water quality baseline, Elena, Cordoba. Argentina; Cromo en aguas subterraneas y superficiales en el entorno de una curtiembre, relacion con valores de fondo natural. Elena, Cordoba. Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Matteoda, E.; Blarasin, M.; Damilano, G.; Cabrera, A.; Giuliano Albo, J.

    2009-07-01

    The basin of the El Barreal stream is a dominantly rural area in which groundwater is used for all activities whereas the stream is used as sink of residues and effluents. The existence of a tannery, which discharge the effluents into a wetland (which is drained by the stream), reveals the need to study the presence of Chromium in surface and groundwater and to compare values derived from pollution with those corresponding to the natural water baseline values. Fifty three samples of surface and groundwater were abstracted and chemical analyses were made, including total Chromium in water and plants. The chemical analysis results were studied by means of conventional and statistical techniques. The local and regional geological characteristics allow us to interpret that Chromium in water is derived from source minerals, being possible to stand out that high values probably are related to nearby serpentinite bodies.The values of total chrome in surface and groundwater are included in the natural quality baseline range calculated for this basin (0,25-5ug/L), exempting those samples with higher values linked to sites with farming activities and to the wetland environment where the Chromium effluent is discharged. In the last place, Chromium was retained in soil and plants whereas the aquifer was affected by a contaminant plume of total dissolved solids because of advective-dispersive transport. In the 2009 monitoring survey, a small increase of Chromium in groundwater was detected in relation to that of 2005, being assumed that partial desorption of Chromium is taking place from the solid phase. (Author) 19 refs.

  20. In the spotlight. Interview with Kenneth Lee, Health Economist, University of Leeds, U.K.. Interview by Johannes Stoelwinder.

    Science.gov (United States)

    Lee, K

    1984-01-01

    Ken Lee appointed to the staff of the Nuffield Centre, University of Leeds, as Lecturer in Health Economics in 1970. He is now Senior Lecturer and Director of the Master's Programme in Health Service Studies. His main teaching interests are in health planning and health economics, and he has carried out research and written extensively on approaches to health economics, health planning and management, care of the elderly, primary health care, health financing, and emergency health services.

  1. Put the concert attendee in the spotlight : A user-centered design and development approach for classical concert applications

    NARCIS (Netherlands)

    Melenhorst, M.S.; Liem, C.C.S.

    2015-01-01

    As the importance of real-life use cases in the music information retrieval (MIR) field is increasing, so does the importance of understanding user needs. The development of innovative real-life applications that draw on MIR technology requires a user-centered design and development approach that

  2. Growing and Supporting the Student and Early Career Pipeline in Earth and Space Sciences - A Spotlight on New AGU Initiatives

    Science.gov (United States)

    Hankin, E. R.; Williams, B. M.; Asher, P. M.; Furukawa, H.; Holm Adamec, B.; Lee, M.; Cooper, P.

    2015-12-01

    The American Geophysical Union (AGU) is home to more than 60,000 scientists from 139 countries. Included in this membership are approximately 20,000 (34%) student and early career members. Many well-established programs within AGU provide a dynamic forum for Earth and Space scientists to advance research, collaborate across disciplines, and communicate the importance and impact of science to society regardless of career stage—programs such as AGU publications, scientific meetings and conferences, honors and recognition, and other educational and scientific forums. Additionally, many AGU program initiatives focusing specifically on supporting student and early career scientists and the global talent pool pipeline ones are actively underway. These include both new and long-standing programs. This presentation will describe (1) the overall demographics and needs in Earth and Space sciences, and (2) AGU's coordinated series of programs designed to help attract, retain and support student and early career scientists—with an emphasis on new programmatic activities and initiatives targeting improved diversity. Included in this presentation are a description of the AGU BrightSTaRS Program, the AGU Berkner Program for international students, a newly established AGU Student & Early Career Conference, the AGU Virtual Poster Showcase initiative, the AGU Meeting Mentor program, and GeoLEAD—an umbrella program being jointly built by a coalition of societies to help address Earth and space sciences talent pool needs.

  3. Explaining Perceptions of Administrative Support among Prison Treatment Staff: A Spotlight on Deputy Wardens in Charge of Treatment

    Science.gov (United States)

    Garland, Brett E.; McCarty, William P.

    2006-01-01

    This paper explores how perceptions of administrative support among 83 treatment staff working in a midwest prison system vary according to personal and work-related variables. It extends on previous literature by: (1) analyzing how perceptions of administrative support vary exclusively among prison treatment staff; (2) focusing on a single type…

  4. From the Margins to the Spotlight: Diverse Deaf and Hard of Hearing Student Populations and Standardized Assessment Accessibility

    Science.gov (United States)

    Cawthon, Stephanie

    2015-01-01

    Designing assessments and tests is one of the more challenging aspects of creating an accessible learning environment for students who are deaf or hard of hearing (DHH), particularly for deaf students with a disability (DWD). Standardized assessments are a key mechanism by which the educational system in the United States measures student…

  5. 21st Century-Based Soft Skills: Spotlight on Non-Cognitive Skills in a Cognitive-Laden Dentistry Program

    Science.gov (United States)

    Quieng, Marjorie C.; Lim, Pearly P.; Lucas, Maria Rita D.

    2015-01-01

    Teaching and learning in the 21st century aims to produce students proficient in content knowledge, specific abilities, literacy, numeracy, and technology uses. From these 21st century skills, soft skills were delineated from these learning outcomes; and defined as intra- and interpersonal skills vital for personal development, social…

  6. Spotlight on unmet needs in stroke prevention: The PIONEER AF-PCI, NAVIGATE ESUS and GALILEO trials.

    Science.gov (United States)

    Hemmrich, Melanie; Peterson, Eric D; Thomitzek, Karen; Weitz, Jeffrey I

    2016-09-28

    Atrial fibrillation (AF) is a major healthcare concern, being associated with an estimated five-fold risk of ischaemic stroke. In patients with AF, anticoagulants reduce stroke risk to a greater extent than acetylsalicylic acid (ASA) or dual antiplatelet therapy (DAPT) with ASA plus clopidogrel. Non-vitamin K antagonist oral anticoagulants (NOACs) are now a widely-accepted therapeutic option for stroke prevention in non-valvular AF (NVAF). There are particular patient types with NVAF for whom treatment challenges remain, owing to sparse clinical data, their high-risk nature or a need to harmonise anticoagulant and antiplatelet regimens if co-administered. This article focuses on three randomised controlled trials (RCTs) that are investigating the utility of rivaroxaban, a direct, oral, factor Xa inhibitor, in additional areas of stroke prevention where data for anticoagulants are lacking: oPen-label, randomized, controlled, multicentre study explorIng twO treatmeNt stratEgiEs of Rivaroxaban and a dose-adjusted oral vitamin K antagonist treatment (PIONEER AF-PCI); New Approach riVaroxoban Inhibition of factor Xa in a Global trial vs Aspirin to prevenT Embolism in Embolic Stroke of Undetermined Source (NAVIGATE ESUS); and Global study comparing a rivAroxaban-based antithrombotic strategy to an antipLatelet-based strategy after transcatheter aortIc vaLve rEplacement to Optimize clinical outcomes (GALILEO). Data from these studies present collaborative efforts to build upon existing registrational Phase III data for rivaroxaban, driving the need for effective and safe treatment of a wider range of patients for stroke prevention.

  7. B cells in the spotlight: innocent bystanders or major players in the pathogenesis of type 1 diabetes.

    Science.gov (United States)

    Silveira, Pablo A; Grey, Shane T

    2006-01-01

    It has long been established that type 1 diabetes (T1D) is a T cell-mediated autoimmune disease, with CD4+ and CD8+ T cells being largely responsible for the destruction of beta cells within the pancreatic islets of Langerhans. Although autoantibodies specific for islet cell proteins are regularly detected in individuals with T1D and can be utilized as effective markers for predicting the onset of disease, they are not believed to be directly pathogenic to beta cells. Thus, activation of autoantibody-secreting B cells has long been regarded as a secondary consequence of the ongoing self-reactive T cell response. However, recently, studies in the nonobese diabetic mouse model of disease have demonstrated that B cells are an important component in the development of T1D by virtue of their ability to act as the preferential antigen presenting cell population required for efficient expansion of diabetogenic CD4+ T cells. Furthermore, autoantibodies might also be responsible for mediating early beta cell pathogenesis in this model.

  8. Parkinson's disease in the spotlight: unraveling nanoscale α-Synuclein oligomers using ultrasensitive single-molecule spectroscopy

    NARCIS (Netherlands)

    Zijlstra, Niels

    2014-01-01

    During the last 15 years, we have witnessed a major shift in the research focus to understand the cause of amyloid diseases. The attention has shifted from the fully matured amyloid fibrils to the nanometer sized aggregation intermediates called oligomers as the potentially cytotoxic species that

  9. Special Issue on Gender and Writing | Gender and literacy issues and research: Placing the spotlight on writing

    Directory of Open Access Journals (Sweden)

    Judy M. Parr

    2012-03-01

    Full Text Available In this introduction to a special issue of the Journal of Writing Research, we review four decades of research, bringing writing to the forefront in conversations devoted to gender and literacy. We identify the impetus for much of the research on gender and writing and situate the four articles in this special issue within three themes: gender patterns in what and how students write, cognitive and socio-cultural factors influencing gender differences in student writing, and attempts to provide alternatives to stereotypical gender patterns in student writing. These interdisciplinary themes, further developed within the four articles, underscore the need to consider gender as a complex social, cognitive and linguistic characteristic of both reading and writing.

  10. Spotlight on nano-theranostics in South Korea: applications in diagnostics and treatment of diseases

    Directory of Open Access Journals (Sweden)

    Lee S

    2015-08-01

    Full Text Available Sangwha Lee,1,* Jongsung Kim,1,* Chung Wung Bark,2 Bonghee Lee,3 Heongkyu Ju,4 Se Chan Kang,5 TaeYoung Kim,6 Moon Il Kim,6 Young Tag Ko,3 Jeong-Seok Nam,3 Hyon Hee Yoon,1 Kyu-Sik Yun,1,6 Young Soo Yoon,1 Seong Soo A An,1,6 John Hulme6 1BioNano Sensor Research Center, 2Department of Electrical Engineering, Gachon University, Seongnam-si, 3Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 4Department of Nano-Physics, 5Department of Life Science, Gachon University, 6Department of BioNano Technology, Gachon BioNano Research Institute, Seongnam-si, South Korea *These authors contributed equally to this work Abstract: From the synergistic integration and the multidisciplinary strengths of the BioNano Sensor Research Center, Gachon Bionano Research Institute, and Lee GilYa Cancer and Diabetes Institute, researchers, students, and faculties at Gachon University in collaboration with other institutions in Korea, Australia, France, America, and Japan have come together to produce a special issue on the diverse applications of nano-theranostics in nanomedicine. This special issue will showcase new research conducted by various scientific groups in Gyonggi-do and Songdo/Incheon, South Korea. The objectives of this special issue are as follows: 1 to bring together and demonstrate some of the latest research results in the field, 2 to introduce new multifunctional nanomaterials and their applications in imaging and detection methods, and 3 to stimulate collaborative interdisciplinary research at both national and international levels in nanomedicine. Keywords: cancer, imaging and therapeutics, antibacterial, disease, neurodegenerative

  11. GSD Update: Year in Review: Spotlight on 2013 research by the Grassland, Shrubland and Desert Ecosystems Science Program

    Science.gov (United States)

    Deborah M. Finch

    2014-01-01

    In this issue of the GSD Update, we take a look back at selected studies of the Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that depict its strengths and focus areas. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic research priorities of the...

  12. GSD Update: Year in Review: Spotlight on 2015 Research by the Grassland, Shrubland and Desert Ecosystems Science Program

    Science.gov (United States)

    Deborah. Finch

    2016-01-01

    In this issue of the GSD Update, we take a look back at selected studies of the Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that depict its strengths and focus areas. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic research...

  13. GSD Update: Year in Review: Spotlight on 2017 Research by the Grassland, Shrubland and Desert Ecosystems Science Program

    Science.gov (United States)

    Deborah M. Finch

    2018-01-01

    In this issue of the GSD Update, we feature selected studies of the RMRS Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that focus on the theme of fire. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic priorities and goals of the USDA Forest...

  14. Spotlight on olaparib in the treatment of BRCA-mutated ovarian cancer: design, development and place in therapy

    Directory of Open Access Journals (Sweden)

    Lorusso D

    2018-05-01

    Full Text Available Domenica Lorusso, Elisa Tripodi, Giuseppa Maltese, Stefano Lepori, Ilaria Sabatucci, Giorgio Bogani, Francesco Raspagliesi Gynecologic Oncology Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy Abstract: Epithelial ovarian cancer is the sixth most common cancer among women worldwide and the first cause of death among gynecological malignancies. Most of the patients present recurrent disease and unfortunately cannot be cured. The unsatisfactory results obtained with salvage chemotherapy have elicited investigators to search for novel biological agents capable of achieving a better control of the disease. In the setting of homologous recombination deficiency, the DNA errors that occur cannot be accurately repaired, and the treatment with poly(ADP-ribose polymerase (PARP inhibition results in definitive cell death in a process called synthetic lethality. As a result of two positive clinical trials, Olaparib was approved in 2014 by U.S. Food and Drug Administration and European Medicines Agency as the first-in-class PARP inhibitor. Olaparib is effective and well tolerated in homologous recombination deficient patients. Several studies with Olaparib have been conducted in the recurrent setting either as maintenance in platinum-responsive patients or as a single agent. Ongoing trials are focused on the use of olaparib as maintenance in the first-line ovarian cancer setting alone or in combination with antiangiogenic agents. Future perspectives will probably investigate the association of olaparib with novel agents as check-point inhibitors and PI3K-AKT inhibitors. The PARP inhibitor era is just at the beginning. Keywords: olaparib, ovarian cancer, PARP inhibitors, homologous recombination deficiency, BRCA mutation

  15. A systematic review of viral infections associated with oral involvement in cancer patients : a spotlight on Herpesviridea

    NARCIS (Netherlands)

    Elad, Sharon; Zadik, Yehuda; Hewson, Ian; Hovan, Allan; Correa, M. Elvira P.; Logan, Richard; Elting, Linda S.; Spijkervet, Fred K. L.; Brennan, Michael T.

    Our aim was to evaluate the literature for the prevalence of and interventions for oral viral infections and, based on scientific evidence, point to effective treatment protocols. Quality of life (QOL) and economic impact were assessed if available in the articles reviewed. Our search of the English

  16. Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy

    Directory of Open Access Journals (Sweden)

    Donald BJ

    2017-12-01

    Full Text Available Bryan J Donald,1,2 Salim Surani,3–5 Harmeet S Deol,1,6 Uche J Mbadugha,1 George Udeani1,7 1Department of Pharmacy, Corpus Christi Medical Center, Corpus Christi, TX, 2Department of Clinical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA, 3Department of Pulmonology/Critical Care, Corpus Christi Medical Center, Corpus Christi, TX, 4Department of Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX, 5Department of Medicine, College of Osteopathic Medicine, University of North Texas Health Science Center, Denton, TX, 6Department of Pharmacy Services, Yale New Haven Hospital, New Haven, CT, 7Pharmacy Practice, College of Pharmacy, Texas A&M University Health Science Center, Kingsville, TX, USA Abstract: Community-acquired bacterial pneumonia (CABP is a leading cause of death worldwide. However, antibacterial agents used to treat common pathogens in CABP are marked by adverse drug events and increasing antimicrobial resistance. Solithromycin is a new ketolide antibiotic, based on the macrolide antibiotic structure, being studied for use in CABP. It has efficacy in vitro against the common causative pathogens in CABP including Streptococcus pneumoniae, Haemophilus influenzae, and atypical pathogens. In Phase II and Phase III clinical trials, it has been demonstrated efficacious as a single agent for treatment of CABP with an apparently milder adverse event profile than alternative agents. Keywords: solithromycin, macrolide antibiotics, community-acquired bacterial pneumonia, CABP

  17. Replacing the Sofa with the Spotlight: Interrogating the Therapeutic Value of Personal Testimony within Community-Based Theatre

    Science.gov (United States)

    Leffler, Elliot

    2012-01-01

    Julie Salverson, a Canadian scholar-practitioner, has long challenged the assumption that personal storytelling within Community-Based Theatre is necessarily therapeutic. Salverson critiques an "aesthetic of injury," arguing that theatre practitioners have foregrounded personal narratives in a way that reinscribes a "victim…

  18. Cultural Psychiatry: A Spotlight on the Experience of Clinical Social Workers' Encounter with Jewish Ultra-Orthodox Mental Health Clients.

    Science.gov (United States)

    Freund, Anat; Band-Winterstein, Tova

    2017-07-01

    Community is a complex issue, especially in two particular populations overlap: Haredi society, which embraces cultural codes common to closed communities, and the mental health population characterized by its own unique needs. The present study explores the encounter experience of social workers with the cultural perceptions of mental health clients in the Haredi community in light of Community Cultural Psychiatry. A qualitative-phenomenological approach was adopted. In-depth semi-structured interviews were conducted with 27 social workers, mental health professionals, who are in contact with ultra-Orthodox Jewish clients. Three major themes emerged from the data analysis: (1) Exclusion vs. grace and compassion. (2) Mental health: A professional or cultural arena? (3) Mental health help-seeking changing processes. This study shows that the attitude in the Haredi community toward mental health therapy undergoes a process of change. It is important to strengthen this process, together with preserving existing community informal structures of help.

  19. From the Margins to the Spotlight: Diverse Deaf and Hard of Hearing Student Populations and Standardized Assessment Accessibility.

    Science.gov (United States)

    Cawthon, Stephanie

    2015-01-01

    Designing assessments and tests is one of the more challenging aspects of creating an accessible learning environment for students who are deaf or hard of hearing (DHH), particularly for deaf students with a disability (DWD). Standardized assessments are a key mechanism by which the educational system in the United States measures student progress, teacher effectiveness, and the impact of school reform. The diversity of student characteristics within DHH and DWD populations is only now becoming visible in the research literature relating to standardized assessments and their use in large-scale accountability reforms. The purpose of this article is to explore the theoretical frameworks surrounding assessment policy and practice, current research related to standardized assessment and students who are DHH and DWD, and potential implications for practice within both the assessment and instruction contexts.

  20. Grantee Spotlight: Manuel L. Penichet, M.D., Ph.D. - Reprogramming the Immune System to Kill Cancer

    Science.gov (United States)

    Dr. Manuel L. Penichet, former CURE K01 trainee and NCI R01 grantee, aims to genetically engineer antibodies that can be used to directly target and eliminate cancer cells and also stimulate the body’s immune system to fight and destroy cancer.

  1. Co-existence of Fisheries and Marine Renewable Energy: The Spotlight on Fishers and Fishers' Knowledge (FK)

    Science.gov (United States)

    Campbell, M. S.; Ashley, M.; De Groot, J.; Rodwell, L.

    2016-02-01

    As an emerging industry, Marine Renewable Energy (MRE) is expected to play a major contributory role if the UK is to successfully reach it's desired target of renewable energy production by 2020. However, due to the competing objectives and priorities of MRE and other industries, for example fisheries, and in the delivering of conservation measures, the demand for space within our marine landscape is increasing, and interactions are inevitable. A semi structured interview was conducted with forty fishers across the UK to elicit further information on the challenges, barriers to progress and priority issues these fishers face in relation to MRE development. The questionnaire also included a fisher assessment of the mitigation agenda developed by de Groot et al. (2014) under the Natural Environment Research Council Marine Renewable Energy Knowledge Exchange Programme ( NERC MREKEP). Qualitative data were extracted and analysed using the text analysis software NVivo8. Fishers identified barriers to progress, and in order of the most important themes included; policy, consultation, trust, lack of knowledge, true representation of all fishers, science vs. fisher observation mismatch and timescales. Priority issues identified in order of importance were; displacement or loss of access, cable disturbance, timings of installation/repairs, effects on the seabed and specifically offshore windfarm (OWF) sitting. The consultation process caused discontent among all fishers interviewed. In relation to working towards a collaborative mitigation agenda, fishers highlighted issues of trust in relation to; trans-boundary management, data management and the consultation process. At all stages of the research, the response rate of the importance of gathering fishers' knowledge (FK) was high. Fishers underlined the importance of this data source in assessing the impacts of MRE on the sectors of the UK fleet. Thus, although at an early stage of development, an initial framework for the collection and application of FK is presented and further work on data needs highlighted.

  2. In the Spotlight of Misperception: Japanese Science Fiction Vis-à-vis Western Science Fiction Set in Japan

    Directory of Open Access Journals (Sweden)

    Baryon Tensor Posadas

    2000-06-01

    Full Text Available In 1984, William Gibson published a novel that began new traditions in science fiction writing —Neuromancer. the novel won a hat-trick of all three of the major science fiction awards: The Hugo, Nebula, and the Philip K. Dick. The opening chapter was set in Chiba prefecture, a large coastal region east of the capital Tokyo with the line "The sky above the port was the color of television turned to a dead channel" (Gibson 1. It was the centerpiece of the cyberpunk movement characterized by a mix of high technology in the fields of computer networking and biomechanical interface and urban street life (Sterling xi.Yet despite its opening scenes being set in Tokyo, Gibson at that time had never set foot in Japan. Furthermore, practically all of Gibson's novels—Neuromancer (1984, Count Zero (1986, Mona Liza Overdrive (1988, Virtual Light (1991, and Idoru (1995 along with several of his short stories, have dealt with Japan in varying degrees, wether as a setting or by involving Japanese social system sush as the yakuza and the zaibatsu system of corporate management as atmospheric elements.Another impetus came from Delia Aguilar's study on Filipino housewives and the politics of gender. This study reveals that " . . . in the private space of the family as the major mechanism for the reproduction of social relations, women are at once validated and oppressed, a process that is powerfully mediated by the maternal ideology of which women are the foremost proponents." This maternal ideology shapes Filipino women's idea of motherhood that sees devotion to children, self-sacrifice, and care giving as the essence of motherhood, allowing them to embrace oppression and subordination. In this context, the interrogation of maternal ideology in Philippine literature is important to the overall feminist movement. Women writers who have freed themselves from the mystifying notions of motherhood may have been inspired to represent women in their works differently.This paper clearly validates such assumption. Writers like Liwayway Arceo, Genoveva Edroza-Matute, Fanny Garcia, Lualhati Bautista, Lilia Quindoza-Santiago, and Luna Sicat-Cleto, as this reading of some of their works reveals, challenge the dominant maternal ideology by re-imagining motherhood. Without wholly rejecting the traditional notion of motherhood (with the exception of Luna Sicat-Cleto who questions the so called "essence" of motherhood, these writers interrogate the idealization of motherhood, question some of the fundamental assumptions of the dominant maternal ideology and represent women as mothers who are nurturing and caring just like the typical image of a Filipino mother, but who are not happy with confinement in the private domestic space. This radical representation of motherhood is, therefore, a welcome development in the present development of feminist discourse in the Philippines.

  3. Fibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction

    Directory of Open Access Journals (Sweden)

    Tenenbaum Alexander

    2012-10-01

    Full Text Available Abstract Currently the world faces epidemic of several closely related conditions: obesity, metabolic syndrome and type 2 diabetes (T2DM. The lipid profile of these patients and those with metabolic syndrome is characterized by the concurrent presence of qualitative as well as quantitative lipoprotein abnormalities: low levels of HDL, increased triglycerides, and prevalence of LDL particles that are smaller and denser than normal. This lipid phenotype has been defined as atherogenic dyslipidemia. Overwhelming evidences demonstrate that all components of the atherogenic dyslipidemia are important risk-factors for cardiovascular diseases. Optimal reduction of cardiovascular risk through comprehensive management of atherogenic dyslipidemias basically depends of the presence of efficacious lipid-modulating agents (beyond statin-based reduction of LDL-C. The most important class of medications which can be effectively used nowadays to combat atherogenic dyslipidemias is the fibrates. From a clinical point of view, in all available 5 randomized control trials beneficial effects of major fibrates (gemfibrozil, fenofibrate, bezafibrate were clearly demonstrated and were highly significant in patients with atherogenic dyslipidemia. In these circumstances, the main determinant of the overall results of the trial is mainly dependent of the number of the included appropriate patients with atherogenic dyslipidemia. In a meta-analysis of dyslipidemic subgroups totaling 4726 patients a significant 35% relative risk reduction in cardiovascular events was observed compared with a non significant 6% reduction in those without dyslipidemia. However, different fibrates may have a somewhat different spectrum of effects. Currently only fenofibrate was investigated and proved to be effective in reducing microvascular complications of diabetes. Bezafibrate reduced the severity of intermittent claudication. Cardinal differences between bezafibrate and other fibrates are related to the effects on glucose metabolism and insulin resistance. Bezafibrate is the only clinically available pan - (alpha, beta, gamma PPAR balanced activator. Bezafibrate decreases blood glucose level, HbA1C, insulin resistance and reduces the incidence of T2DM compared to placebo or other fibrates. Among major fibrates, bezafibrate appears to have the strongest and fenofibrate the weakest effect on HDL-C. Current therapeutic use of statins as monotherapy is still leaving many patients with atherogenic dyslipidemia at high risk for coronary events because even intensive statin therapy does not eliminate the residual cardiovascular risk associated with low HDL and/or high triglycerides. As compared with statin monotherapy (effective mainly on LDL-C levels and plaque stabilization, the association of a statin with a fibrate will also have a major impact on triglycerides, HDL and LDL particle size. Moreover, in the specific case of bezafibrate one could expect neutralizing of the adverse pro-diabetic effect of statins. Though muscle pain and myositis is an issue in statin/fibrate treatment, adverse interaction appears to occur to a significantly greater extent when gemfibrozil is administered. However, bezafibrate and fenofibrate seems to be safer and better tolerated. Combined fibrate/statin therapy is more effective in achieving a comprehensive lipid control and may lead to additional cardiovascular risk reduction, as could be suggested for fenofibrate following ACCORD Lipid study subgroup analysis and for bezafibrate on the basis of one small randomized study and multiple observational data. Therefore, in appropriate patients with atherogenic dyslipidemia fibrates- either as monotherapy or combined with statins – are consistently associated with reduced risk of cardiovascular events. Fibrates currently constitute an indispensable part of the modern anti-dyslipidemic arsenal for patients with atherogenic dyslipidemia.

  4. Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets

    Directory of Open Access Journals (Sweden)

    Armelle T. Mbaveng

    2017-06-01

    Full Text Available Cancer remains a major health hurdle worldwide and has moved from the third leading cause of death in the year 1990 to second place after cardiovascular disease since 2013. Chemotherapy is one of the most widely used treatment modes; however, its efficiency is limited due to the resistance of cancer cells to cytotoxic agents. The present overview deals with the potential of the flora of Central, Eastern and Western African (CEWA regions as resource for anticancer drug discovery. It also reviews the molecular targets of phytochemicals of these plants such as ABC transporters, namely P-glycoprotein (P-gp, multi drug-resistance-related proteins (MRPs, breast cancer resistance protein (BCRP, ABCG2 as well as the epidermal growth factor receptor (EGFR/ErbB-1/HER1, human tumor suppressor protein p53, caspases, mitochondria, angiogenesis, and components of MAP kinase signaling pathways. Plants with the ability to preferentially kills resistant cancer cells were also reported. Data compiled in the present document were retrieved from scientific websites such as PubMed, Scopus, Sciencedirect, Web-of-Science, and Scholar Google. In summary, plant extracts from CEWA and isolated compounds thereof exert cytotoxic effects by several modes of action including caspases activation, alteration of mitochondrial membrane potential (MMP, induction of reactive oxygen species (ROS in cancer cells and inhibition of angiogenesis. Ten strongest cytotoxic plants from CEWA recorded following in vitro screening assays are: Beilschmiedia acuta Kosterm, Echinops giganteus var. lelyi (C. D. Adams A. Rich., Erythrina sigmoidea Hua (Fabaceae, Imperata cylindrical Beauv. var. koenigii Durand et Schinz, Nauclea pobeguinii (Pobég. ex Pellegr. Merr. ex E.M.A., Piper capense L.f., Polyscias fulva (Hiern Harms., Uapaca togoensis Pax., Vepris soyauxii Engl. and Xylopia aethiopica (Dunal A. Rich. Prominent antiproliferative compounds include: isoquinoline alkaloid isotetrandrine (51, two benzophenones: guttiferone E (26 and isoxanthochymol (30, the isoflavonoid 6α-hydroxyphaseollidin (9, the naphthyl butenone guieranone A (25, two naphthoquinones: 2-acetylfuro-1,4-naphthoquinone (4 and plumbagin (37 and xanthone V1 (46. However, only few research activities in the African continent focus on cytotoxic drug discovery from botanicals. The present review is expected to stimulate further scientific efforts to better valorize the African flora.

  5. Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets

    Science.gov (United States)

    Mbaveng, Armelle T.; Kuete, Victor; Efferth, Thomas

    2017-01-01

    Cancer remains a major health hurdle worldwide and has moved from the third leading cause of death in the year 1990 to second place after cardiovascular disease since 2013. Chemotherapy is one of the most widely used treatment modes; however, its efficiency is limited due to the resistance of cancer cells to cytotoxic agents. The present overview deals with the potential of the flora of Central, Eastern and Western African (CEWA) regions as resource for anticancer drug discovery. It also reviews the molecular targets of phytochemicals of these plants such as ABC transporters, namely P-glycoprotein (P-gp), multi drug-resistance-related proteins (MRPs), breast cancer resistance protein (BCRP, ABCG2) as well as the epidermal growth factor receptor (EGFR/ErbB-1/HER1), human tumor suppressor protein p53, caspases, mitochondria, angiogenesis, and components of MAP kinase signaling pathways. Plants with the ability to preferentially kills resistant cancer cells were also reported. Data compiled in the present document were retrieved from scientific websites such as PubMed, Scopus, Sciencedirect, Web-of-Science, and Scholar Google. In summary, plant extracts from CEWA and isolated compounds thereof exert cytotoxic effects by several modes of action including caspases activation, alteration of mitochondrial membrane potential (MMP), induction of reactive oxygen species (ROS) in cancer cells and inhibition of angiogenesis. Ten strongest cytotoxic plants from CEWA recorded following in vitro screening assays are: Beilschmiedia acuta Kosterm, Echinops giganteus var. lelyi (C. D. Adams) A. Rich., Erythrina sigmoidea Hua (Fabaceae), Imperata cylindrical Beauv. var. koenigii Durand et Schinz, Nauclea pobeguinii (Pobég. ex Pellegr.) Merr. ex E.M.A., Piper capense L.f., Polyscias fulva (Hiern) Harms., Uapaca togoensis Pax., Vepris soyauxii Engl. and Xylopia aethiopica (Dunal) A. Rich. Prominent antiproliferative compounds include: isoquinoline alkaloid isotetrandrine (51), two benzophenones: guttiferone E (26) and isoxanthochymol (30), the isoflavonoid 6α-hydroxyphaseollidin (9), the naphthyl butenone guieranone A (25), two naphthoquinones: 2-acetylfuro-1,4-naphthoquinone (4) and plumbagin (37) and xanthone V1 (46). However, only few research activities in the African continent focus on cytotoxic drug discovery from botanicals. The present review is expected to stimulate further scientific efforts to better valorize the African flora. PMID:28626426

  6. Spotlight on siponimod and its potential in the treatment of secondary progressive multiple sclerosis: the evidence to date

    Directory of Open Access Journals (Sweden)

    Gajofatto A

    2017-11-01

    Full Text Available Alberto Gajofatto Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy Abstract: Siponimod (BAF312 is a synthetic molecule belonging to the sphingosine-1-phosphate (S1P modulator family, which has putative neuroprotective properties and well-characterized immunomodulating effects mediated by sequestration of B and T cells in secondary lymphoid organs. Compared to fingolimod (ie, precursor of the S1P modulators commercially available for the treatment of relapsing–remitting [RR] multiple sclerosis [MS], siponimod exhibits selective affinity for types 1 and 5 S1P receptor, leading to a lower risk of adverse events that are mainly induced by S1P3 receptor activation, such as bradycardia and vasoconstriction. In addition, S1P1 and S1P5 receptors are expressed by neurons and glia and could mediate a possible neuroprotective effect of the drug. A Phase II clinical trial of siponimod for RR MS showed a significant effect of the active drug compared to placebo on reducing gadolinium-enhancing lesions on brain magnetic resonance imaging (MRI after 3 months of treatment. In a recently completed Phase III trial, treatment with siponimod was associated with a significant reduction in disability progression in secondary progressive (SP MS patients compared to placebo. In this article, current evidence supporting siponimod efficacy for SP MS is reviewed. Keywords: multiple sclerosis, siponimod, progression, disability, treatment

  7. Fibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction.

    Science.gov (United States)

    Tenenbaum, Alexander; Fisman, Enrique Z

    2012-10-11

    Currently the world faces epidemic of several closely related conditions: obesity, metabolic syndrome and type 2 diabetes (T2DM). The lipid profile of these patients and those with metabolic syndrome is characterized by the concurrent presence of qualitative as well as quantitative lipoprotein abnormalities: low levels of HDL, increased triglycerides, and prevalence of LDL particles that are smaller and denser than normal. This lipid phenotype has been defined as atherogenic dyslipidemia. Overwhelming evidences demonstrate that all components of the atherogenic dyslipidemia are important risk-factors for cardiovascular diseases. Optimal reduction of cardiovascular risk through comprehensive management of atherogenic dyslipidemias basically depends of the presence of efficacious lipid-modulating agents (beyond statin-based reduction of LDL-C). The most important class of medications which can be effectively used nowadays to combat atherogenic dyslipidemias is the fibrates. From a clinical point of view, in all available 5 randomized control trials beneficial effects of major fibrates (gemfibrozil, fenofibrate, bezafibrate) were clearly demonstrated and were highly significant in patients with atherogenic dyslipidemia. In these circumstances, the main determinant of the overall results of the trial is mainly dependent of the number of the included appropriate patients with atherogenic dyslipidemia. In a meta-analysis of dyslipidemic subgroups totaling 4726 patients a significant 35% relative risk reduction in cardiovascular events was observed compared with a non significant 6% reduction in those without dyslipidemia. However, different fibrates may have a somewhat different spectrum of effects. Currently only fenofibrate was investigated and proved to be effective in reducing microvascular complications of diabetes. Bezafibrate reduced the severity of intermittent claudication. Cardinal differences between bezafibrate and other fibrates are related to the effects on glucose metabolism and insulin resistance. Bezafibrate is the only clinically available pan - (alpha, beta, gamma) PPAR balanced activator. Bezafibrate decreases blood glucose level, HbA1C, insulin resistance and reduces the incidence of T2DM compared to placebo or other fibrates. Among major fibrates, bezafibrate appears to have the strongest and fenofibrate the weakest effect on HDL-C. Current therapeutic use of statins as monotherapy is still leaving many patients with atherogenic dyslipidemia at high risk for coronary events because even intensive statin therapy does not eliminate the residual cardiovascular risk associated with low HDL and/or high triglycerides. As compared with statin monotherapy (effective mainly on LDL-C levels and plaque stabilization), the association of a statin with a fibrate will also have a major impact on triglycerides, HDL and LDL particle size. Moreover, in the specific case of bezafibrate one could expect neutralizing of the adverse pro-diabetic effect of statins. Though muscle pain and myositis is an issue in statin/fibrate treatment, adverse interaction appears to occur to a significantly greater extent when gemfibrozil is administered. However, bezafibrate and fenofibrate seems to be safer and better tolerated. Combined fibrate/statin therapy is more effective in achieving a comprehensive lipid control and may lead to additional cardiovascular risk reduction, as could be suggested for fenofibrate following ACCORD Lipid study subgroup analysis and for bezafibrate on the basis of one small randomized study and multiple observational data. Therefore, in appropriate patients with atherogenic dyslipidemia fibrates- either as monotherapy or combined with statins - are consistently associated with reduced risk of cardiovascular events. Fibrates currently constitute an indispensable part of the modern anti-dyslipidemic arsenal for patients with atherogenic dyslipidemia.

  8. Spin doctors in the spotlight: Effects of strategic press and publicity coverage on perceptions of political PR

    NARCIS (Netherlands)

    de Vreese, C.H.; Elenbaas, M.

    2009-01-01

    News media often engage in strategy framing when covering politics, including strategic press and publicity coverage coined to express the focus on the media's role in the game of politics, as well as politicians’ calculated publicity and public relations efforts in relation to the media. This study

  9. Frequently Asked Questions (Palliative Care: Conversations Matter)

    Science.gov (United States)

    ... Medicine at NINR Research Highlights Data Science and Nursing Research Spotlight on End-of-Life and Palliative Care Research Spotlight on Symptom Management Research Spotlight on Pain Research The Science of Compassion: Future Directions in ...

  10. National Institute of Nursing Research

    Science.gov (United States)

    ... Medicine at NINR Research Highlights Data Science and Nursing Research Spotlight on End-of-Life and Palliative Care Research Spotlight on Symptom Management Research Spotlight on Pain Research The Science of Compassion: Future Directions in ...

  11. La construcción de la imagen heroica a través del discurso periodístico. El caso de la activista peruana María Elena Moyano.

    OpenAIRE

    Gabriela McEvoy.

    2008-01-01

    This work tries to demonstrate that the social construction of the national hero/heroine as a symbol of courage and resistance generally arises within a period of social, political, and economic crisis. The national hero is a construction that is created in a moment characterized by the loss of public trust and the failure of government leaders to act. The creation of the heroic image functions as a sociopolitical tool. The article suggests that there is a close relationship between the histo...

  12. Sobre la inscripción lusitano-latina de Viseu en Elena Redondo-Moyano y María José García Soler (eds.) Nuevas interpretaciones del Mundo Antiguo

    OpenAIRE

    Siles Ruiz, Jaime

    2016-01-01

    Se estudia el interesante 'bilingüismo' del ara de Visseu, cuya dedicatoria a las divinidades indígenas está escrita en lengua lusitana, mientras que el nombre, filiación y acción del dedicante están escritos en latín. Y se propone una interpretación tanto del rotacismo que la primera parte del texto presenta como de lo que parece un elemento copulativo o enclítico.

  13. La construcción de la imagen heroica a través del discurso periodístico: El caso de la activista peruana María Elena Moyano

    OpenAIRE

    McEvoy, Gabriela

    2008-01-01

    Este trabajo intenta demostrar que la construcción social del héroe/heroína nacional como símbolo de coraje y resistencia surge generalmente dentro de un periodo de crisis social, política y económica. El héroe nacional es una construcción que se presenta en un momento caracterizado por la pérdida de confianza pública y la falta de acción de los gobernantes. La configuración de la imagen heroica funciona como instrumento sociopolítico. Este trabajo sugiere que hay una relación entrañable entr...

  14. Elaboración de hormigones que minimicen el impacto al ambiente, empleando neumáticos usados de vehículos livianos y pesados, en la provincia de Santa Elena

    OpenAIRE

    Armando Saltos

    2016-01-01

    Las llantas usadas son consideradas un foco de riesgo ambiental y sanitario a nivel mundial, por ejemplo en Ecuador se desecha al año, según la Corporación para la Promoción Proactiva de Inversiones (INVEC), cerca de 2,4 millones de neumáticos de diversos tipos, lo que equivale a 55.000 toneladas. La menor parte de ellos son reutilizados para el reencauchado, pero la gran mayoría es incinerada o depositada en basureros a cielo abierto, lo que supone una amenaza contra el medio ambiente y ries...

  15. Estudio del comercio electrónico como estrategia de negocios dentro de las empresas que brindan servicios de hospedaje en el Cantón Salinas, provincia de Santa Elena.

    OpenAIRE

    Mateo López, Blanca Annabell

    2015-01-01

    El presente trabajo tiene como objetivo analizar los mecanismos de promoción y comercialización, que utilizan los establecimientos que brindan servicios de hospedaje en Salinas, identificando los medios de comunicación que manejan para potenciar sus negocios. Al conocer que a nivel mundial existen varias estrategias soportadas en medios digitales por parte de los hoteles, se ha determinado la necesidad de los empresarios hoteleros de tener en sus empresas una página web, o mejoras...

  16. Estudio sobre las Competencias Demandadas por las Empresas, para la Inserción Laboral de los Profesionales en la Provincia de Santa Elena año 2013.

    OpenAIRE

    Jairo Cedeño; Karina Bricio

    2015-01-01

    La presente investigación tiene como objetivo determinar las competencias demandadas por las empresas tanto públicas y privadas de la provincia y analiza la inserción laboral de los profesionales. Hoy en día las empresas crecen, se expanden y esa es la oportunidad para que las universidades oferten estudiantes con habilidades, destrezas y conocimientos de acuerdo a lo que las empresas demandan. Por ello la importancia de este estudio el cual determinó las competencias que demandan las empresa...

  17. MARÍA ELENA DÍEZ JORGE. Mujeres y arquitectura: mudéjares y cristianas en la construcción Granada: Universidad, 2011, 330 pp. y 4 planos

    Directory of Open Access Journals (Sweden)

    Esther Galera Mendoza

    2016-06-01

    Full Text Available Los estudios sobre arte y género cuentan ya con una sólida trayectoria y siguen proyectándose hacia el futuro gracias a nuevas investigaciones que están revelando ámbitos de actuación y protagonistas insospechadas en el mundo artístico a lo largo del tiempo. Este es el caso del libro que nos ocupa. El recorrido historiográfico por la historia del arte desde una perspectiva de género con el que comienza el texto recuerda la obra de Linda Nochlin Why Have There Been No Great Women Artis?, que abrió el camino a numerosas investigaciones que trataban de rescatar la figura y trayectoria de mujeres de gran talento artístico cuyos nombres y creaciones fueron silenciadas por la historia. Las más recientes investigaciones sobre arte y género, como la que nos ocupa, ponen de manifiesto la necesidad de prestar atención no sólo a las grandes creadoras sino también al trabajo de los talleres pues en ellos es posible descubrir la actividad artística de muchas mujeres que si bien no podían acceder a la maestría sí lograban colaborar o realizar sus obras en estos talleres. [...

  18. INCIDENCIA DE LA INVESTIGACIÓN BIBLIOGRÁFICA EN EL APRENDIZAJE EN ESTUDIANTES DEL NIVEL BÁSICO DE LA CARRERA ADMINISTRACIÓN DE EMPRESAS DE UNIVERSIDAD ESTATAL PENÍNSULA DE SANTA ELENA

    Directory of Open Access Journals (Sweden)

    William Caiche Rosales

    2017-01-01

    Full Text Available El desarrollo de hábitos de lectura en estudiantes de educación superior representa un verdadero reto para el docente, sobre todo por que dicha práctica impulsa la capacidad de analizar y de emitir juicios de valor y consolida las bases cognitivas que recibe en el proceso de aprendizaje, Se ha identificado que, el estudiante de Administración de empresas en el desarrollo de actividades académicas cita referencias bibliográficas que, de manera mayoritaria provienen de consultas de bajo nivel académico, por otro lado, es escaso el número de referencias que incluye, esta situación limita el aprendizaje, y se refleja en los resultados de evaluación del proceso. Este trabajo plantea como objetivo determinar el efecto que tiene en el aprendizaje la implementación de una guía de investigación bibliográfica para el nivel básico en los estudiantes de la Carrera Administración de Empresas de la UPSE; para el efecto se recurre a un diseño de investigación explicativo que a través de la comparación del antes y el después permita verificar el logro de tal objetivo.   ABSTRACT The development of habits of reading in students of higher education represents a real challenge for the teacher, especially because this practice promotes the ability to analyse and make value judgments and strengthens cognitive bases in the learning process, has been identified, the student of business management in the development of academic activities cited references thatmajority way come from queries of low academic level, on the other hand, numbers, including is little, this situation limits learning, and it is reflected in the results of the process evaluation. This work is aimed at determining the effect that has on learning the implementation of a guide of bibliographic research for the basic level students of the business administration career of the UPSE; the effect is relied on to an explanatory research design which through a comparison of the before and then allow to verify the achievement of such a goal.

  19. Análisis de los sistemas de gestión del conocimiento en la empacadora grupo Granmar: división laboratorio de larvas Semacua S.A de la provincia de Santa Elena – Ecuador

    Directory of Open Access Journals (Sweden)

    Mónica Jaramillo

    2016-11-01

    The management of intangible assets that generate value for the organization are those that have to do with the processes related to the transmission of knowledge, for this reason a model of knowledge management is designed, with the use of ICT tools to streamline the process and improve the use of the access mechanisms and finding information, since those operating not currently guarantee a correct transfer of information or adequate learning, growing importance as a new production factor has turned development of technologies , methodologies and strategies to become one of the main priorities of organizations in the knowledge society. It is known that the market is increasingly competitive, which demands greater innovation in products, therefore, knowledge must be developed and assimilated more and more quickly, which is achieved by having an automated process that meets policies security for information processing. The management model is aimed at people who apply technology focused knowledge sharing, because the companies take full advantage of their knowledge, repeat not waste time tasks or perform them to share knowledge in the organization.

  20. Proyecto de inversión para la producción y comercialización de plaguicidas de aloe vera en la península de Santa Elena

    OpenAIRE

    Mestanza Vera, Sonia Elizabeth; Jaramillo Montero, Leysi Magali; Tobalina Ditto, Constantino Francisco

    2009-01-01

    Los plaguicidas sintéticos fueron una solución a inicios de la llamada revolución verde a los problemas de plagas y enfermedades, pero su composición química a llevado a grandes debates desde hace diez años y manteniéndose en la actualidad. Incluso los mercados de mayor demanda de alimentos como EE.UU. y U.E. han optado por exigir a sus proveedores alimentos orgánicos, es decir sin residuos de moléculas de plaguicidas, ante esta nueva política de mercado, es necesario encontrar alter...

  1. Estudio del polvo de vidrio obtenido de la molienda de botellas recicladas en la provincia de Santa Elena, como sustituto parcial del cemento en el hormigón

    Directory of Open Access Journals (Sweden)

    Juan Garcés Vargas

    2016-12-01

      The present study consists in reusing glass bottle wastes by crushing and grounding them into a fineness that allows the partial substitute of cement in the concrete. This is because when glass has been finely grounded to a micron size, it acts as a high reactivity pozzolana. Cement is the main component for producing concrete; it is also the one that causes the highest impact to the environment because the clinker production requires high energy consumption.  There are studies to diminish the energy consumption, such as the substitution of fossil fuel for high calorific power residues, or by diminishing or substituting cement in construction without affecting its quality, and improving its mechanical properties. That is obtained by using materials such as flying ashes, blast furnace slags or silica fume, and the use of recycled materials, among others.  The use of recycled material in concrete supposes a double benefit: on the one hand wastes are diminished and, on the other hand, the mechanical properties of concrete can be improved.  That said, glass is a material that due to its physical and chemical properties, is an ideal candidate for recycling it in high percentage.

  2. Demanda laboral y oferta de capacitación del Secap en el área de hotelería y turismo para la provincia de Santa Elena año 2012

    OpenAIRE

    Morales Hurtado, Aura

    2012-01-01

    PDF La Formación del talento humano en gestión hotelera, la elevación de la calidad de la formación de los profesionales, tiene como objetivo formar profesionales que den respuestas a las necesidades actuales y del desarrollo turístico, económico y social del país, constituye el centro de actividad y propósito fundamental de la educación técnica ecuatoriana y como parte de ella ésta el Servicio Ecuatoriano de Capacitación Profesional SECAP en el área de hotelería y turism...

  3. Spotlight on fluticasone furoate/vilanterol trifenatate for the once-daily treatment of asthma: design, development and place in therapy

    Directory of Open Access Journals (Sweden)

    Albertson TE

    2016-12-01

    Full Text Available Timothy E Albertson,1–3 Samuel W Bullick,1,3 Michael Schivo,1 Mark E Sutter2,3 1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, 2Department of Emergency Medicine, School of Medicine, UC Davis, Sacramento, 3Department of Medicine, Veterans Administration Northern California Health Care System, Mather, CA, USA Abstract: The use of inhaled corticosteroids (ICSs plays a key role in the treatment of asthmatic patients, and international guidelines have designated ICSs as an early maintenance therapy in controlling asthma symptoms. When asthmatic patients remain symptomatic on ICSs, one common option is to add a long-acting beta2 agonist (LABA to the maintenance treatment. Fixed combination inhalers that contain both an ICS and a LABA have been popular for both chronic obstructive pulmonary disease (COPD and asthma. Historically, these inhalers have been dosed twice daily. However, currently, there is a once-daily combination therapy with the ICS fluticasone furoate (FF and the LABA vilanterol trifenatate (VI with indications for use in both COPD and asthma. This dry powder inhaler (DPI comes in two doses of FF (100 or 200 µg both combined with VI (25 µg. This article reviews the clinical trial data for FF, VI and FF/VI combination inhalers and documents the efficacy and safety of once-daily inhaled maintenance therapy by DPI in asthmatic patients. Keywords: fluticasone furoate/vilanterol trifenatate, asthma, long-acting beta2 agonist, inhaled corticosteroid, combined inhaler, persistent asthma, dry powder inhaler  

  4. The rise of photoresponsive protein technologies applications in vivo: a spotlight on zebrafish developmental and cell biology [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Renee Wei-Yan Chow

    2017-04-01

    Full Text Available The zebrafish (Danio rerio is a powerful vertebrate model to study cellular and developmental processes in vivo. The optical clarity and their amenability to genetic manipulation make zebrafish a model of choice when it comes to applying optical techniques involving genetically encoded photoresponsive protein technologies. In recent years, a number of fluorescent protein and optogenetic technologies have emerged that allow new ways to visualize, quantify, and perturb developmental dynamics. Here, we explain the principles of these new tools and describe some of their representative applications in zebrafish.

  5. Spotlight on crizotinib in the first-line treatment of ALK-positive advanced non-small-cell lung cancer: patients selection and perspectives

    Directory of Open Access Journals (Sweden)

    Giroux Leprieur E

    2016-06-01

    Full Text Available Etienne Giroux Leprieur,1,2 Vincent Fallet,3,4 Jacques Cadranel,3,4 Marie Wislez3,4 1Respiratory Diseases and Thoracic Oncology Department, APHP-Ambroise Paré Hospital, Boulogne-Billancourt, France; 2EA4340 Laboratory, UVSQ, Paris-Saclay University, France; 3Respiratory Diseases Department, APHP – Tenon Hospital, Paris, France; 4Sorbonne University, GRC 04, UPMC Univ Paris 06, France Abstract: Around 4% of advanced non-small-cell lung cancers (NSCLCs have an ALK rearrangement at the time of diagnosis. This molecular feature is more frequent in young patients, with no/light smoking habit and with adenocarcinoma pathological subtype. Crizotinib is a tyrosine kinase inhibitor, targeting ALK, ROS1, RON, and MET. The preclinical efficacy results led to a fast-track clinical development. The US Food and Drug Administration (FDA approval was achieved after the Phase I clinical trial in 2011 in ALK-rearranged advanced NSCLC progressing after a first-line treatment. In 2013, the randomized Phase III trial PROFILE-1007 confirmed the efficacy of crizotinib in ALK-rearranged NSCLC, compared to cytotoxic chemotherapy, in second-line setting or more. In 2014, the PROFILE-1014 trial showed the superiority of crizotinib in the first-line setting compared to the pemetrexed platinum doublet chemotherapy. The response rate was 74%, and the progression-free survival was 10.9 months with crizotinib. Based on these results, crizotinib received approval from the FDA and European Medicines Agency for first-line treatment of ALK-rearranged NSCLC. The various molecular mechanisms at the time of the progression (ALK mutations or amplification, ALK-independent mechanisms encourage performing re-biopsy at the time of progression under crizotinib. The best treatment strategy at the progression (crizotinib continuation beyond progression, switch to second-generation tyrosine kinase inhibitors, or cytotoxic chemotherapy depends on the phenotype of the progression, the molecular status, and the physical condition of the patient. Keywords: ALK rearrangement, crizotinib, non-small-cell lung carcinoma

  6. The evolution of the Italian EPR system for the management of household Waste Electrical and Electronic Equipment (WEEE). Technical and economic performance in the spotlight.

    Science.gov (United States)

    Favot, Marinella; Veit, Raphael; Massarutto, Antonio

    2016-10-01

    In this paper we analyse the Italian collective system for the management of household Waste Electrical and Electronic Equipment (WEEE), and its evolution over time, following the European Directives on WEEE, which include the Extended Producer Responsibility (EPR). The analysis focuses on the technical and economic performance of WEEE compliance organisations (consortia), as they are the key players in the Italian EPR regime. Economic results have not usually been provided in previous studies, due to the lack of available data. This study overcomes this problem by accessing the financial statements for the years 2009-2014 of all consortia. The main conclusions of the study are: The Italian EPR system barely exceeded the technical target of the first WEEE Directive (4kg per capita). Improvements are necessary to achieve the target set for 2019 by the Recast Directive. The economic performance of the Italian EPR regime improved significantly over time. The fees charged per tonne of WEEE collected decreased by almost 43% from 652 Euro per tonne in 2009 to 374 Euro per tonne in 2014, while the fees per tonne put on the market (POM) were 134 Euro in 2009 and 104 Euro in 2014. The results prove the theory which states that, competing consortia use the learning effects to reduce the contribution fees for producers rather than to increase the quantity collected. Municipalities remain the most important actor in WEEE collection operations. Consortia compensate municipalities with a reimbursement that ranges between 28 and 38 Euros per tonne collected. These repayments cover only partially their costs. Additional studies should investigate their role. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Organization Spotlight: The Power of an Association in Early Childhood Education and Care: ISSA--An Engine for Advocacy, Capacity Building, and Creating a Growing Learning Community

    Science.gov (United States)

    Ionescu, Mihaela

    2015-01-01

    The International Step by Step Association (ISSA) is an association that believes in learning from each other across cultures and borders, building on each other's strengths, and tapping into the power of a network. Building on the strong legacy of the Open Society Foundations' Step by Step program, ISSA has nurtured a culture of belonging to a…

  8. Data Use "Multi-State" Spotlight: Using Data Fidelity Tools to Improve Data Quality. Transforming State Systems to Improve Outcomes for Children with Disabilities

    Science.gov (United States)

    Ruedel, Kristin; Nelson, Gena; Bailey, Tessie

    2018-01-01

    To evaluate interim progress toward the State-identified Measurable Result (SIMR), states require access to high-quality data from local education agencies (LEAs) and early intervention service providers. In a review of 2017 Phase III State Systemic Improvement Plans (SSIP), 43 Part C states noted limitations or concerns related to data and…

  9. Going beyond "First Impressions": Jane Austen on the spotlightDOI:10.5007/2175-8026.2010n59p101

    Directory of Open Access Journals (Sweden)

    Carla Alexandra Ferreira

    2010-03-01

    Full Text Available The last decades has seen a proliferation of Jane Austen’s novels for television and cinema. Despite being an important movement for the popularity of her literary work that has also brought some problems for a serious understanding of Austen’s literary project. The purpose of this essay is to point out the need of considering the changes, preferences and omissions, apparently not very important or carried out because of some demands of the translation from a novel to the cinema, that occur when her work is revisited. We will try to show some choices made in the transference from her novels to film may erase part of the writer’s fictional project which is among other things to portray women’s role in the nineteenth century patriarchal English society and try to change women’s condition of invisibility that had been created and spread since Enlightenment. In order to illustrate our point the 2005 version of Pride and Prejudice for the cinema will be used.

  10. ON THE STAGE OF LIFE, DEATH IN THE SPOTLIGHT: THE REPERCUSSIONS OF TERMINALITY IN ICU FOR THE FAMILY AND THE MEDICAL TEAM

    OpenAIRE

    MAYLA COSMO MONTEIRO

    2015-01-01

    As UTIs se tornaram o lugar frequente de morte para grande parte das pessoas no mundo. A morte ou a ameaça da perda de um ente querido promovem desequilíbrio no sistema familiar, fazendo emergir sensações de impotência, de fragilidade e de vulnerabilidade. Para a equipe médica, a morte do paciente traz a possibilidade de entrar em contato com os próprios processos de morte e finitude, suscitando angústia e desconforto. O processo de medicalização da morte traz em seu bojo qu...

  11. Antimicrobial Peptides: a promising class of antimicrobial compounds against BWA and multi-drug resistant bacteria: in the spotlight: the lactoferrin chimera

    NARCIS (Netherlands)

    Bikker, F.J.; Sijbrandij, T.; Nazmi, K.; Bolscher, J.G.M.; Veerman, E.C.I.; Jansen, H-J.

    2014-01-01

    Anti-Microbial Peptides (AMPs) are part of the innate immune defense system and considered as promising lead compounds for the development of novel anti-bacterial agents. In general, AMPs are simple, short peptides with broad-spectrum activity against Gram-negative and Gram-positive bacteria, fungi,

  12. The associations between domain-specific sedentary behaviours and dietary habits in European adults: a cross-sectional analysis of the SPOTLIGHT survey

    Directory of Open Access Journals (Sweden)

    Sofie Compernolle

    2016-10-01

    Full Text Available Abstract Background Sedentary behaviour has been associated with obesity and related chronic diseases. Disentangling the nature of this association is complicated due to interactions with other lifestyle factors, such as dietary habits, yet limited research has investigated the relation between domain-specific sedentary behaviours and dietary habits in adults. The aim of this paper was to examine the association between domain-specific sedentary behaviours and dietary habits in adults and to test the moderating effect of age and gender on this association. Methods A total of 6,037 participants from five urban regions in Europe completed an online survey, of which 6,001 were included in the analyses. Multilevel mixed-effects logistic regression analyses were used to examine main associations and interaction effects. Results All domain-specific sedentary behaviours, except transport-related sitting time, were significantly related to dietary habits. In general, having a higher sitting time was related to having less healthy dietary habits, especially for television viewing. Gender did not moderate any of the relations, and age was only a significant moderator in the relation between other leisure sitting time and alcohol consumption. Conclusion Domain-specific sitting behaviours were related to unhealthy dietary behaviours. However, the small effect sizes suggest that individual level behavioural interventions focusing on sedentary behaviour will not be sufficient to improve dietary habits. The fact that almost none of the associations were moderated by age or gender suggests that these associations, and possibly also the effects of interventions targeting both behaviours, may hold across age and gender groups.

  13. The associations between domain-specific sedentary behaviours and dietary habits in European adults: a cross-sectional analysis of the SPOTLIGHT survey.

    Science.gov (United States)

    Compernolle, Sofie; De Cocker, Katrien; Teixeira, Pedro J; Oppert, Jean-Michel; Roda, Célina; Mackenbach, Joreintje D; Lakerveld, Jeroen; McKee, Martin; Glonti, Ketevan; Rutter, Harry; Bardos, Helga; Cardon, Greet; De Bourdeaudhuij, Ilse

    2016-10-06

    Sedentary behaviour has been associated with obesity and related chronic diseases. Disentangling the nature of this association is complicated due to interactions with other lifestyle factors, such as dietary habits, yet limited research has investigated the relation between domain-specific sedentary behaviours and dietary habits in adults. The aim of this paper was to examine the association between domain-specific sedentary behaviours and dietary habits in adults and to test the moderating effect of age and gender on this association. A total of 6,037 participants from five urban regions in Europe completed an online survey, of which 6,001 were included in the analyses. Multilevel mixed-effects logistic regression analyses were used to examine main associations and interaction effects. All domain-specific sedentary behaviours, except transport-related sitting time, were significantly related to dietary habits. In general, having a higher sitting time was related to having less healthy dietary habits, especially for television viewing. Gender did not moderate any of the relations, and age was only a significant moderator in the relation between other leisure sitting time and alcohol consumption. Domain-specific sitting behaviours were related to unhealthy dietary behaviours. However, the small effect sizes suggest that individual level behavioural interventions focusing on sedentary behaviour will not be sufficient to improve dietary habits. The fact that almost none of the associations were moderated by age or gender suggests that these associations, and possibly also the effects of interventions targeting both behaviours, may hold across age and gender groups.

  14. Model-free nuclear magnetic resonance study of intermolecular free energy landscapes in liquids with paramagnetic Ln3+ spotlights: theory and application to Arg-Gly-Asp.

    Science.gov (United States)

    Fries, Pascal H

    2012-01-28

    We propose an easily applicable method for investigating the pair distribution function of a lanthanide Ln(3+) complex LnL (L = ligand) with respect to any solvent or solute molecule A carrying observable nuclear spins. Let r be the distance of Ln(3+) to the observed nuclear spin I. We derive a simple expression of the experimental value of the configurational average of 1/r(6) in terms of longitudinal paramagnetic relaxation (rate) enhancements (PREs) of the spin I measured on a standard high-resolution NMR spectrometer and due to well-chosen concentrations of LnL complexes in which Ln(3+) is a fast-relaxing paramagnetic lanthanide or the slowly-relaxing gadolinium Gd(3+). The derivation is justified in the general case of a molecule A which is by turns in a bound state where it follows the complex and a free state where it moves independently. It rests on the expression of the underlying PRE theory in terms of the angle-dependent pair distribution function of LnL and A. The simplifications of this theory in the high-field regime and under the condition of fast exchange between bound and free states are carefully discussed. We also show that original information on the angle dependence of the molecular pair distribution function can be gained from the measured paramagnetic dipolar shifts induced by complexed fast-relaxing Ln(3+) ions. The method is illustrated by the case study of the anionic Lnttha(3-) = [Ln(3+)(ttha)](3-) (ttha(6-) = triethylene tetraamine hexacetate) complex interacting with the biologically important tripeptide Arg-Gly-Asp (RGD) which carries peripheral ionic groups. The usefulness of an auxiliary reference outer sphere probe solute is emphasized. © 2012 American Institute of Physics

  15. Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection—Liver: The “Musketeer” in the Spotlight

    Science.gov (United States)

    Ballestri, Stefano; Nascimbeni, Fabio; Romagnoli, Dante; Baldelli, Enrica; Targher, Giovanni; Lonardo, Amedeo

    2016-01-01

    The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of fatty (simple steatosis and steatohepatitis) and non-fatty liver changes (NASH-cirrhosis with or without hepatocellular carcinoma (HCC)) that are commonly observed among individuals with multiple metabolic derangements, notably including visceral obesity, IR and T2D. Hepatitis C virus (HCV) infection is also often associated with both hepatic steatosis and features of a specific HCV-associated dysmetabolic syndrome. In recent years, the key role of the steatotic liver in the development of IR and T2D has been increasingly recognized. Thus, in this comprehensive review we summarize the rapidly expanding body of evidence that links T2D with NAFLD and HCV infection. For each of these two liver diseases with systemic manifestations, we discuss the epidemiological burden, the pathophysiologic mechanisms and the clinical implications. To date, substantial evidence suggests that NAFLD and HCV play a key role in T2D development and that the interaction of T2D with liver disease may result in a “vicious circle”, eventually leading to an increased risk of all-cause mortality and liver-related and cardiovascular complications. Preliminary evidence also suggests that improvement of NAFLD is associated with a decreased incidence of T2D. Similarly, the prevention of T2D following HCV eradication in the era of direct-acting antiviral agents is a biologically plausible result. However, additional studies are required for further clarification of mechanisms involved. PMID:27005620

  16. Spotlight on once-monthly long-acting injectable aripiprazole and its potential as maintenance treatment for bipolar I disorder in adult patients

    Directory of Open Access Journals (Sweden)

    Torres-Llenza V

    2018-01-01

    Full Text Available Vanessa Torres-Llenza, Pooja Lakshmin, Daniel Z Lieberman Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, Washington, DC, USA Abstract: The lack of long-term medication adherence is a challenge in the treatment of bipolar disorder, particularly during the maintenance phase when symptoms are less prominent. The rate of nonadherence is ~20%–60% depending on how strict a definition is used. Nonadherence worsens the course of bipolar disorder and can add hundreds of thousands of dollars to the lifetime cost of treating the illness. Long-acting injectable (LAI medication is an attractive alternative to daily dosing of oral medication, especially among patients who are ambivalent about treatment. The purpose of this paper is to review the evidence for the safety and efficacy of LAI aripiprazole, which was recently approved for the treatment of bipolar disorder. The approval was based on a single double-blind, placebo-controlled, multisite trial that recruited participants from 103 sites in 7 countries. A total of 731 participants with bipolar disorder were enrolled in the study. Out of that total, 266 were successfully stabilized on LAI aripiprazole and entered the randomization phase. Treatment-emergent adverse events were, for the most part, mild to moderate. Akathisia was the most common adverse event, which, combined with restlessness, was experienced by 23% of the sample. At the end of the 52-week study period, nearly twice as many LAI-treated participants remained stable compared to those treated with placebo. Stability during the maintenance phase is arguably the most important goal of treatment. It is during this period of relative freedom from symptoms that patients are able to build a meaningful and satisfying life. The availability of a new treatment agent, particularly one that has the potential to enhance long-term adherence, is a welcome development. Keywords: antipsychotic, adherence, partial agonist, mood stabilizer, review

  17. Methodological challenges in indirect treatment comparisons: spotlight on a recent comparison of long-acting injectable aripiprazole versus paliperidone palmitate in the treatment of schizophrenia.

    Science.gov (United States)

    Singh, Arun; Gopal, Srihari; Kim, Edward; Mathews, Maju; Kern-Sliwa, Jennifer; Turkoz, Ibrahim; Wooller, Annette; Berlin, Jesse

    2018-03-01

    In a recent study, an indirect treatment comparison was performed to examine the relative efficacy and tolerability of aripiprazole once monthly and paliperidone palmitate once monthly. The authors concluded that the results may suggest relative advantages for aripiprazole once monthly over paliperidone palmitate once monthly in the short-term treatment of schizophrenia. However, the validity of the study is compromised as an indirect treatment comparison using extant data may violate important assumptions. Other methodological issues identified further highlight the challenges of performing indirect treatment comparisons.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/.

  18. Fracking. Technical aspects in the spotlight; Fracking. Technische Aspekte im Fokus. Von Exxon in Auftrag gegebene Studie schaetzt die Gefahren des Frackings als beherrschbar ein

    Energy Technology Data Exchange (ETDEWEB)

    Lengsdorf, Gerd

    2012-11-01

    The statement is not new, but is repeatedly a tropical subject. Further technological developments permit advances, e.g. in medicine, production, communication or energy supply. This is particularly clear from the example of natural gas. As with other fossil energy sources the resources are also limited in this case, which is all the more painful, because natural gas is an ideal product in the creation of the energy revolution. In this situation it is highly appropriate that with a special method it is possible to exploit deposits, which could not be developed economically until a few decades ago. (orig.)

  19. Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection—Liver: The “Musketeer” in the Spotlight

    Directory of Open Access Journals (Sweden)

    Stefano Ballestri

    2016-03-01

    Full Text Available The pathogenesis of type 2 diabetes (T2D involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR, which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liver disease (NAFLD encompasses a spectrum of fatty (simple steatosis and steatohepatitis and non-fatty liver changes (NASH-cirrhosis with or without hepatocellular carcinoma (HCC that are commonly observed among individuals with multiple metabolic derangements, notably including visceral obesity, IR and T2D. Hepatitis C virus (HCV infection is also often associated with both hepatic steatosis and features of a specific HCV-associated dysmetabolic syndrome. In recent years, the key role of the steatotic liver in the development of IR and T2D has been increasingly recognized. Thus, in this comprehensive review we summarize the rapidly expanding body of evidence that links T2D with NAFLD and HCV infection. For each of these two liver diseases with systemic manifestations, we discuss the epidemiological burden, the pathophysiologic mechanisms and the clinical implications. To date, substantial evidence suggests that NAFLD and HCV play a key role in T2D development and that the interaction of T2D with liver disease may result in a “vicious circle”, eventually leading to an increased risk of all-cause mortality and liver-related and cardiovascular complications. Preliminary evidence also suggests that improvement of NAFLD is associated with a decreased incidence of T2D. Similarly, the prevention of T2D following HCV eradication in the era of direct-acting antiviral agents is a biologically plausible result. However, additional studies are required for further clarification of mechanisms involved.

  20. Spotlight on equality of employment opportunities: A qualitative study of job seeking experiences of graduating nurses and physiotherapists from black and minority ethnic backgrounds.

    Science.gov (United States)

    Hammond, John; Marshall-Lucette, Sylvie; Davies, Nigel; Ross, Fiona; Harris, Ruth

    2017-09-01

    There is growing attention in the UK and internationally to the representation of black and minority ethnic groups in healthcare education and the workplace. Although the NHS workforce is very diverse, ethnic minorities are unevenly spread across occupations, and considerably underrepresented in senior positions. Previous research has highlighted that this inequality also exists at junior levels with newly qualified nurses from non-White/British ethnic groups being less likely to get a job at graduation than their White/British colleagues. Although there is better national data on the scale of inequalities in the healthcare workforce, there is a gap in our understanding about the experience of job seeking, and the factors that influence disadvantage in nursing and other professions such as physiotherapy. This qualitative study seeks to fill that gap and explores the experience of student nurses (n=12) and physiotherapists (n=6) throughout their education and during the first 6-months post qualification to identify key experiences and milestones relating to successful employment particularly focusing on the perspectives from different ethnic groups. Participants were purposively sampled from one university to ensure diversity in ethnic group, age and gender. Using a phenomenological approach, in-depth semi-structured interviews were conducted at course completion and 6 months later. Two main themes were identified. The 'proactive self' ('It's up to me') theme included perceptions of employment success being due to student proactivity and resilience; qualities valued by employers. The second theme described the need to 'fit in' with organisational culture. Graduates described accommodating strategies where they modified aspects of their identity (clothing, cultural markers) to fit in. At one extreme, rather than fitting in, participants from minority ethnic backgrounds avoided applying to certain hospitals due to perceptions of discriminatory cultures, 'I wouldn't apply there 'cos you know, it's not really an ethnic hospital'. In contrast, some participants recognised that other graduates (usually white) did not need to change and aspects of their identity brought unsolicited rewards 'if your face fits then the barriers are reduced'. The findings indicate that success in getting work is perceived as determined by individual factors, and fitting in is enabled by strategies adopted by the individual rather than the workplace. Demands for change are more acute for graduates from black and minority ethnic backgrounds. This is an issue for healthcare organisations seeking to be inclusive and challenges employers and educators to acknowledge inequalities and take action to address them. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. LLRF beam results on the first year of ELENA’s commissioning with beam

    CERN Document Server

    Angoletta, Maria Elena; Molendijk, John; Sanchez Quesada, Jorge; CERN. Geneva. ATS Department

    2018-01-01

    CERN’s Extra Low ENergy Antiproton (ELENA) ring’s commissioning with beam started in earnest in March 2017. Ions from an H- source were injected in ELENA at low energy, although in a degraded way (lower voltage and intensity than planned) and with not constant reproducibility of the injection. From August 2017 onwards antiprotons from the AD were also injected in ELENA at high energy for up to three, weekly MD session. The 2017 ELENA commissioning run stopped on December 1st to allow the installation of the electron cooler. This note gives an overview of the successful operation carried out by the ELENA Low-Level RF (LLRF) during the first year of ELENA commissioning and of the main beam results obtained. Operation with H- ions and with antiprotons are considered, together with different operational settings and problems encountered. Hints on future deployment and commissioning steps are also provided.

  2. Book Reviews

    OpenAIRE

    Elena Mancusi-Materi

    2002-01-01

    Book reviews: Helmore, K. and N. Singh, Sustainable Livelihoods – Building on the Wealth of the poor (reviewed by Elena Mancusi-Materi); Scoones, I (ed.), Dinamics and Diversity: Soil fertility and farming livelihoods in africa (reviewed by Elena Mancusi-Materi); Uphoff, N. (ed.), Agroecological Innovations – Increasing Food Production with Pariciatory Development (reviewed by Elena Mancusi-Materi); Marten, G.G., Human Ecology, Basic Concepts for Sustianable Development (reviewed by Siobhán K...

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Partners & Collaborators Spotlight on Scientists Research Areas Cancer Biology Research Cancer Genomics Research Research on Causes of ... Collaborators Spotlight on Scientists NCI Research Areas Cancer Biology Cancer Genomics Causes of Cancer Diagnosis Prevention Screening & ...

  4. Chest X-Ray

    Medline Plus

    Full Text Available ... Professions Site Index A-Z Spotlight June is Men's Health Month Recently posted: How to Obtain and ... Thank you for your time! Spotlight June is Men's Health Month Recently posted: How to Obtain and ...

  5. Your Radiologist Explains Nuclear Medicine

    Medline Plus

    Full Text Available ... Professions Site Index A-Z Spotlight June is Men's Health Month Recently posted: How to Obtain and ... Thank you for your time! Spotlight June is Men's Health Month Recently posted: How to Obtain and ...

  6. Your Radiologist Explains Magnetic Resonance Angiography (MRA)

    Medline Plus

    Full Text Available ... Professions Site Index A-Z Spotlight June is Men's Health Month Recently posted: How to Obtain and ... time and for your attention! Spotlight June is Men's Health Month Recently posted: How to Obtain and ...

  7. New Genetic Susceptibility Factors for Sjögren's Syndrome Revealed

    Science.gov (United States)

    ... Spotlight on Research Spotlight on Research New Genetic Susceptibility Factors for Sjögren’s Syndrome Revealed By Kirstie Saltsman, ... swallowing and speaking. “The identification of these genetic susceptibility factors opens up new avenues for understanding how ...

  8. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Laboratory for Cancer Research Partners & Collaborators Spotlight on Scientists Research Areas Cancer Biology Research Cancer Genomics Research ... Centers Frederick National Lab Partners & Collaborators Spotlight on Scientists NCI Research Areas Cancer Biology Cancer Genomics Causes ...

  9. Your Radiologist Explains Magnetic Resonance Angiography (MRA)

    Medline Plus

    Full Text Available ... Site Index A-Z Spotlight Recently posted: Pancreatic Cancer The Limitations of Online Dose Calculators Video: The ... and for your attention! Spotlight Recently posted: Pancreatic Cancer The Limitations of Online Dose Calculators Video: The ...

  10. Rh Disease

    Science.gov (United States)

    ... Order bereavement materials News Moms Need Blog News & Media News Videos Mission stories Ambassadors Spotlights Tools & Resources Frequently ... Order bereavement materials News Moms Need Blog Stories & Media News & Media News Videos Mission stories Ambassadors Spotlights Tools & ...

  11. Instructions and Manuals

    DEFF Research Database (Denmark)

    2007-01-01

    -Myto (Konstantin Grcic) + Canasta collection (Patricia Urquiola) -K-Clinic (Koji Kawaguchi) -Wolf House (Juan Carlos Heijboer) -Biblioteca Sant'Elena e Costantino (Italo Rota)......-Myto (Konstantin Grcic) + Canasta collection (Patricia Urquiola) -K-Clinic (Koji Kawaguchi) -Wolf House (Juan Carlos Heijboer) -Biblioteca Sant'Elena e Costantino (Italo Rota)...

  12. Estrogen Metabolism and Prostate Cancer Risk: A Prospective Study

    Science.gov (United States)

    2008-05-01

    standard, linguaggio comune , necessario a stabilire protocolli di collaborazione) Start Up Progetto Certificazione ISO 9001, IFO, Rome, Italy 3rd December...28 June 2008 CONCLUSIONS In summary, in the context of a still limited scientific panorama, our study and meta- analysis provide evidence...Department of Urology, National Cancer Institute Regina Elena, Rome, Italy 7 Scientific Direction, National Cancer Institute Regina Elena, Rome, Italy

  13. Reference: 590 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 590 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17450124i Caro Elena et al. 2007 May. Nature... to root epidermis patterning in Arabidopsis. 7141 213-7 17450124 2007 May Nature Caro Elena|Castellano M Mar|Gutierrez Crisanto

  14. Supporting learning experiences beyond the school context

    NARCIS (Netherlands)

    Rusman, Ellen

    2015-01-01

    In this workshop you’ll become familiar with two examples of how technology can support learning experiences that go beyond, but still connect to, the school context. The first example, called Elena, is for primary schools. The second example, called weSPOT, is for secondary schools. The Elena

  15. ELENA’s International Collaboration is born

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    On 13 June, ten institutes signed a Memorandum of Understanding (MoU) for the construction of the Extra Low ENergy Antiproton ring (ELENA). Allowing the further deceleration of antiprotons from the Antimatter Decelerator, ELENA will significantly increase the number of particles trapped downstream in the experimental set-ups. This will give an important boost to antimatter research in the years to come.   Electrostatic triplet lenses - a device that will transport antiprotons from ELENA to the experiments. The electrostatic device was successfully tested with the ASACUSA experiment two weeks ago. ELENA - an upgrade of the existing Antiproton Decelerator (AD) - was approved by the CERN Council last year under the condition that external user institutions would contribute to its construction. On 13 June, the foundation stone of the new international collaboration was laid with the signature of the MoU. ELENA is a small magnetic decelerator ring 30 m in circumference that will fit inside the ...

  16. Language experience narratives and the role of autobiographical reasoning in becoming an urban science teacher

    Science.gov (United States)

    Rivera Maulucci, Maria S.

    2011-06-01

    One of the central challenges globalization and immigration present to education is how to construct school language policies, procedures, and curricula to support academic success of immigrant youth. This case-study compares and contrasts language experience narratives along Elena's developmental trajectory of becoming an urban science teacher. Elena reflects upon her early language experiences and her more recent experiences as a preservice science teacher in elementary dual language classrooms. The findings from Elena's early schooling experiences provide an analysis of the linkages between Elena's developing English proficiency, her Spanish proficiency, and her autobiographical reasoning. Elena's experiences as a preservice teacher in two elementary dual language classrooms indicates ways in which those experiences helped to reframe her views about the intersections between language learning and science learning. I propose the language experience narrative, as a subset of the life story, as a way to understand how preservice teachers reconstruct past language experiences, connect to the present, and anticipate future language practices.

  17. Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management

    Directory of Open Access Journals (Sweden)

    K. Govind Babu

    2016-01-01

    Full Text Available Background. Acute promyelocytic leukemia is characterized by t(15;17. This leads to the formation of PML/RARα which blocks the differentiation of blasts at the stage of promyelocytes. This is reversed by all-trans-retinoic acid (ATRA, a vitamin A derivative. Acute myocardial ischemia is a rare side effect of ATRA. Case Report. We report a case of acute coronary syndrome manifesting as an adverse effect of ATRA in a lady with APL who had no other risk factors for cardiovascular disease. Conclusions. We emphasize the need for high index of suspicion for the diagnosis of this entity. In the light of this case, the rare instances of ATRA associated acute myocardial ischemia recorded in the literature and the options available for treatment of acute promyelocytic leukemia sans ATRA have been reviewed.

  18. Spotlight on the human factor: building a foundation for the future of haemophilia A management: report from a symposium on human recombinant FVIII at the World Federation of Hemophilia World Congress, Melbourne, Australia on 12 May 2014.

    Science.gov (United States)

    Kessler, C; Oldenburg, J; Ettingshausen, C Escuriola; Tiede, A; Khair, K; Négrier, C; Klamroth, R

    2015-01-01

    Inhibitor development is the most serious and challenging complication in the treatment of severe haemophilia A. Up to 38% of such patients develop inhibitors with current recombinant factor VIII (rFVIII) products produced in hamster cell lines. Human-cl rhFVIII is a new generation fully sulfated B-domain-deleted FVIII coagulant glycoprotein, which is generated from a human cell line. Thus, there are no non-human epitopes which would be potentially immunogenic. This molecule has significantly higher VWF-binding affinity compared with existing full-length rFVIII produced in hamster cell lines. The development aim of Human-cl rhFVIII is to address the challenges of FVIII inhibitors and frequent infusions during prophylaxis. Human-cl rhFVIII's mean half-life is very comparable to some of the newer products which involve modification of the FVIII molecule to extend the circulating half-life. There are promising data concerning the use of a personalized prophylaxis regimen with Human-cl rhFVIII. Preliminary data indicate a median dosing interval of 3.5 days with 66.7% of the patients on a twice per week or fewer infusions schedule combined with a low bleeding rate and no increased FVIII consumption when compared to standard prophylaxis. No product-specific laboratory assay is required to monitor the coagulation activity for Human-cl rhFVIII. The results of registration clinical trials with Human-cl rhFVIII as well as the ongoing studies in previously untreated patients (NuProtect) and personalized prophylaxis study in previously treated patients (NuPreviq), will be discussed. The manufacturer has received marketing authorization for Human-cl rhFVIII in Europe and Canada under the name Nuwiq(®) and plans to launch it in the USA and globally in 2015. © 2014 John Wiley & Sons Ltd.

  19. "Kollane huntmees" Kultuuritehases

    Index Scriptorium Estoniae

    2008-01-01

    Kultuuritehases Polymer näidatakse üritustesarja "La Cinema Extraordinaire" raames täna kell 14 Andrus Joonase filmi "Kollane huntmees" ja kell 18 Elena Tejada Ferrera filmi "Selection of Perfomance" (Peruu - Ameerika Ühendriigid)

  20. Keskkonnakaitse Nobel läks apalatshile / Arni Alandi

    Index Scriptorium Estoniae

    Alandi, Arni, 1969-

    2003-01-01

    Goldmani keskkonnapreemia võitis Julia Bonds. Ülejäänud preemiad jagunesid maailma eri paikadesse. Nende saajad olid Odigha Odigha, Von Hernandez, Maria Elena Foronda Farrol, Pedro Arrojo-Agudo, Eileen Kampakuta Brown ja Eileen Wani Wingfield

  1. Installation of the Gbar LINAC

    CERN Multimedia

    Maximilien, Brice

    2017-01-01

    Installation of the GBAR linac in its shielding bunker. The electrons accelerated to 10 MeV toward a target will produce the positrons that are necessary to form anti hydrogen with the antiprotons coming from the ELENA decelerator.

  2. Browse Title Index

    African Journals Online (AJOL)

    Items 201 - 250 of 399 ... ... Synedrella nodiflora (L) Gaertn in male Sprague-Dawley rats: biochemical, ... Benoit B N'guessan, Isaac J Asiedu-Gyekye, Alexander K Nyarko .... Theophilus Adiku, Elena Delgado, Margaret Lartey, William K. Ampofo.

  3. San Francisco Littoral Cell CRSMP Coastal Armoring Lines 2011

    Data.gov (United States)

    California Natural Resource Agency — This dataset is an updated version of the shapefile created by Jennifer Dare at the California Coastal Commission in 2005. The version created by Elena Vandebroek...

  4. San Francisco Littoral Cell CRSMP Coastal Armoring Areas 2011

    Data.gov (United States)

    California Natural Resource Agency — This dataset is an updated version of the shapefile created by Jennifer Dare at the California Coastal Commission in 2005. The version created by Elena Vandebroek...

  5. The team from AB Department that brought the accelerator chain to a new intensity record on 2 October.

    CERN Multimedia

    Patrice Loiez

    2004-01-01

    From left to right, sitting: Elena Shaposhnikova, Thomas Bohl, Gianluigi Arduini, and standing: Klaus Hanke, Trevor Linnecar, Rende Steerenberg, Michel Chanel, Roland Garoby, Elias Métral. Not pictured: Steven Hancock and Bernard Vandorpe.

  6. San Francisco Littoral Cell CRSMP Coastal Armoring Areas 2011

    Data.gov (United States)

    California Department of Resources — This dataset is an updated version of the shapefile created by Jennifer Dare at the California Coastal Commission in 2005. The version created by Elena Vandebroek...

  7. San Francisco Littoral Cell CRSMP Coastal Armoring Lines 2011

    Data.gov (United States)

    California Department of Resources — This dataset is an updated version of the shapefile created by Jennifer Dare at the California Coastal Commission in 2005. The version created by Elena Vandebroek...

  8. Equal opportunities group. His mission : accelerating equal opportunities at CERN

    CERN Multimedia

    Patrice Loïez

    2000-01-01

    L. to r.: Michel Mayoud, Christine Petit-Jean-Genaz, the Equal Opportunities Officer Sudeshna Datta-Cockerill, Elena Wildner, Anne-Sylvie Cerne, Karl-Heinz Kissler, the Chairman John Ellis and Eva-Maria Groniger-Voss

  9. Markko Märtin : sain maailma parima kaardilugeja

    Index Scriptorium Estoniae

    2005-01-01

    Markko Märtin rääkis ajakirjale Autosport traagilisest avariist ja hukkunud kaardilugejast Michael Parkist. Michael Parki meenutavad: Robert Reid, Paul Turner, Sebastien Loeb, David Higgins, Malcolm Wilson, Daniel Elena, David Evans

  10. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Domestic Volunteerism Spotlight Contact Us Military Health System Strategic Partnership Military Health System Strategic Partnership Military Health System Strategic Partnership About Excelsior ...

  11. Baseline Bone Mineral Density Measurements Key to Future Testing Intervals

    Science.gov (United States)

    ... Research | April 3, 2018 Optimizing Steroid Treatment for Duchenne Muscular Dystrophy Spotlight on Research | March 8, 2018 The Role of the Microbiota in Eczema: Findings Suggest That Striking ...

  12. What Are the Treatments for Osteogenesis Imperfecta?

    Science.gov (United States)

    ... and Developmental Disabilities (IDDs) NICHD News Spotlights Podcast: DNA Day: Battling Brittle Bone ... OUTREACH Safe to Sleep® National Child & Maternal Health Education Program RELATED WEBSITES ...

  13. How Do Health Care Providers Diagnose Osteogenesis Imperfecta?

    Science.gov (United States)

    ... and Developmental Disabilities (IDDs) NICHD News Spotlights Podcast: DNA Day: Battling Brittle Bone ... OUTREACH Safe to Sleep® National Child & Maternal Health Education Program RELATED WEBSITES ...

  14. What Are the Symptoms of Osteogenesis Imperfecta?

    Science.gov (United States)

    ... and Developmental Disabilities (IDDs) NICHD News Spotlights Podcast: DNA Day: Battling Brittle Bone ... OUTREACH Safe to Sleep® National Child & Maternal Health Education Program RELATED WEBSITES ...

  15. Texas Heart Institute

    Science.gov (United States)

    ... of seminars and conferences. Resources Texas Heart Institute Journal Scientific Publications Library & Learning Resources Resources for Physicians Fellowships & Residencies School of Perfusion Technology THI Spotlight Check out the ...

  16. The Disposal of Hazardous Wastes.

    Science.gov (United States)

    Barnhart, Benjamin J.

    1978-01-01

    The highlights of a symposium held in October, 1977 spotlight some problems and solutions. Topics include wastes from coal technologies, radioactive wastes, and industrial and agricultural wastes. (BB)

  17. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Domestic Volunteerism Spotlight Contact Us Military Health System Strategic Partnership Military Health System Strategic Partnership Military Health System Strategic Partnership About Excelsior ...

  18. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Volunteerism Spotlight Contact Us Military Health System Strategic Partnership Military Health System Strategic Partnership Military Health System Strategic Partnership About Excelsior Surgical ...

  19. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Volunteerism Spotlight Contact Us Military Health System Strategic Partnership Military Health System Strategic Partnership Military Health System Strategic Partnership About Excelsior Surgical ...

  20. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Events Domestic Volunteerism Spotlight Contact Us Military Health System Strategic Partnership Military Health System Strategic Partnership Military Health System Strategic Partnership About ...