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Sample records for spotlight elena angulo1

  1. ELENA

    CERN Multimedia

    Caraban Gonzalez, Noemi

    2016-01-01

    ELENA is a compact ring for cooling and further deceleration of 5.3 MeV antiprotons delivered by the CERN Antiproton Decelerator. The AD physics program is focused on trapping antiprotons in Penning traps where antihydrogen is formed after recombination with positrons. The ultimate physics goal is to perform spectroscopy on antihydrogen atoms at rest and to investigate the effect of the gravitational force on matter and antimatter.

  2. Encuentros con Elena Poniatowska

    OpenAIRE

    Uzquiza González, José Ignacio

    2008-01-01

    El autor analiza, desde su encuentro con Elena Poniatowska, la vertiente de la literatura testimonial como literatura de mujeres. Un análisis interior de la relación entre realidad y ficción, entre Elena, Jesusa o Tinísima. The author analyzes testimonial literature from the perspective of female literature through his meeting with Elena Poniatowska. An analysis of reality vs. Fiction in Elena, Jesusa and Tinisima.

  3. Elena App for Android

    NARCIS (Netherlands)

    Ternier, Stefaan; Rusman, Ellen; Storm, Jeroen

    2014-01-01

    The ‘ELENA goes shopping' mobile game is developed within the ELENA-project. This European project develops materials to teach children between 4 and 8 years the basics of French, German and Dutch. The aim is to familiarize children from border regions with languages that are available in their

  4. The ELENA facility

    Science.gov (United States)

    Bartmann, Wolfgang; Belochitskii, Pavel; Breuker, Horst; Butin, Francois; Carli, Christian; Eriksson, Tommy; Oelert, Walter; Ostojic, Ranko; Pasinelli, Sergio; Tranquille, Gerard

    2018-03-01

    The CERN Antiproton Decelerator (AD) provides antiproton beams with a kinetic energy of 5.3 MeV to an active user community. The experiments would profit from a lower beam energy, but this extraction energy is the lowest one possible under good conditions with the given circumference of the AD. The Extra Low Energy Antiproton ring (ELENA) is a small synchrotron with a circumference a factor of 6 smaller than the AD to further decelerate antiprotons from the AD from 5.3 MeV to 100 keV. Controlled deceleration in a synchrotron equipped with an electron cooler to reduce emittances in all three planes will allow the existing AD experiments to increase substantially their antiproton capture efficiencies and render new experiments possible. ELENA ring commissioning is taking place at present and first beams to a new experiment installed in a new experimental area are foreseen in 2017. The transfer lines from ELENA to existing experiments in the old experimental area will be installed during CERN Long Shutdown 2 (LS2) in 2019 and 2020. The status of the project and ring commissioning will be reported. This article is part of the Theo Murphy meeting issue `Antiproton physics in the ELENA era'.

  5. ELENA Project - Experiment soon complete

    CERN Multimedia

    Brice, Maximilien

    2016-01-01

    ELENA is a compact ring for cooling and further deceleration of 5.3 MeV antiprotons delivered by the CERN Antiproton Decelerator. The AD physics program is focused on trapping antiprotons in Penning traps where antihydrogen is formed after recombination with positrons. The ultimate physics goal is to perform spectroscopy on antihydrogen atoms at rest and to investigate the effect of the gravitational force on matter and antimatter.

  6. The ELENA project at CERN

    CERN Document Server

    Oelert, W

    2015-01-01

    CERN has a longstanding tradition of pursuing fundamental physics on extreme low and high energy scales. The present physics knowledge is successfully described by the Standard Model and the General Relativity. In the anti-matter regime many predictions of this established theory still remain experimentally unverified and one of the most fundamental open problems in physics concerns the question of asymmetry between particles: why is the observable and visible universe apparently composed almost entirely of matter and not of anti-matter? There is a huge interest in the very compelling scientiic case for anti-hydrogen and low energy anti-proton physics, here to name especially the Workshop on New Opportunities in the Physics Landscape at CERN which was convened in May 2009 by the CERN Directorate and culminated in the decision for the final approval of the construction of the Extra Low ENergy Antiproton (ELENA) ring by the Research Board in June 2011. ELENA is a CERN project aiming to construct a small 30 m ci...

  7. The ELENA Beam Diagnostics Systems

    CERN Document Server

    Tranquille, G

    2013-01-01

    The Extra Low ENergy Antiproton ring (ELENA) to be built at CERN is aimed at substantially increasing the number of antiprotons to the low energy antiproton physics community. It will be a small machine which will decelerate low intensity beams (<4x107) from 5.3 MeV to 100 keV and will be equipped with an electron cooler to avoid beam losses during the deceleration and to significantly reduce beam phase space at extraction. To measure the beam parameters from the extraction point of the Antiproton Decelerator (AD), through the ELENA ring and all the way to the experiments, many systems will be needed to ensure that the desired beam characteristics are obtained. Particular attention needs to be paid to the performance of the electron cooler which depends on reliable instrumentation in order to efficiently cool the antiprotons. This contribution will present the different monitors that have been proposed to measure the various beam parameters as well as some of the developments going on to further improve th...

  8. Significant Silence in Elena Garro's "Los Perros"

    Science.gov (United States)

    Burke, Jessica

    2010-01-01

    Elena Garro's one-act play "Los perros" (1958) confronts the difficult issue of sexual violence in rural Mexico, a problem that persists today. The characters struggle with the social reality of rape, alluding to the threat of sexual violence while avoiding addressing it directly. While words are granted an almost magical power in…

  9. Ecotourism: The Santa Elena Rainforest Project.

    Science.gov (United States)

    Wearing, Stephen

    1993-01-01

    Describes an ecotourism project in which the community of Santa Elena, Costa Rica, are developing a rainforest reserve on government land leased permanently to the local high school. Discusses the impact of the project on the community's economy and environment. (Contains 30 references.) (MDH)

  10. NEUTRINOS: Moriond spotlight

    International Nuclear Information System (INIS)

    Petcov, S.T.

    1991-01-01

    The regular 'Rencontres de Moriond' meetings in the French Alps, which celebrate their 25th anniversary this year, have a strong tradition of reflecting new trends in physics thinking and January's session on 'Tests of Fundamental Laws in Physics' was no exception. The spotlight this time fell on the neutrino sector, a branch of physics frequently in evolution, if not controversial

  11. Design Study: ELENA Bending Magnet Prototype

    CERN Document Server

    Schoerling, D

    2013-01-01

    The ELENA bending magnet prototype shall prove that the proposed design meets the requirements set by the ELENA beam dynamics. The following points will be discussed in detail: (i) production process of a magnetic yoke diluted with stainless steel plates, (ii) the stability and repeatability of the field homogeneity of such a yoke over the full working range, (iii) choice of soft magnetic steel, (iv) hysteresis effects, (v) mechanical deformations, (vi) thermal insulation to intercept heat load from baking for activation of NEG coating in the vacuum chamber, (vii) end shim design. In order to verify these points the following measurements will be performed: (i) Hall probe scanning, (ii) integrated field homogeneity measurement (DC), (iii) integrated field homogeneity measurement (AC).

  12. ELENA gets a roof over its head

    CERN Multimedia

    Anaïs Schaeffer

    2014-01-01

    Today, Friday 11 April, CERN inaugurated the ELENA building (393) after less than a year's construction work.   Tacked on to the side of the Antiproton Decelerator (AD), this building will soon house a cleaning room, workshops and generators for the kickers in order to free space in the AD hall, where the future Extra Low ENergy Antiproton ring, ELENA, will be installed. “Today we’re celebrating the completion of a project which, I’m happy to say, has gone very well,” exclaims François Butin, technical coordinator of the ELENA project (EN-MEF Group). “The deadlines and budgets have been perfectly respected and the building fully complies with our specifications. A great vote of thanks to GS-SE and the outside contractors who have enabled us to complete this project.” Some 10,000 tonnes of earth had to be moved by around 500 trucks. The presence of the TT2 transfer tunnel directly beneath the building posed a number...

  13. Helena Paz-Elena Garro: La Memoria Compartida Helena Paz-Elena Garro: La Memoria Compartida

    Directory of Open Access Journals (Sweden)

    Ana María Alba Villalobos

    2012-02-01

    Full Text Available En el texto se analizan las Memorias de Helena Paz, a la luz de los textos autobiográficos y biográficos acerca de la vida de Elena Garro. El planteamiento estriba en que hay muchos elementos que permiten afirmar que una parte sustancial de las memorias (inéditas de Elena Garro se encuentran insertas en las Memorias de su hija, Helena Paz. Se muestran aquí los argumentos para tal aseveración y los fragmentos que corresponderían a las vivencias de la madre, más que de la hija This text analyzes Helena Paz’s Memoirs, in the light of the autobiographical and biographical texts about Elena Garro’s life. The thesis of the text is that there are many elements supporting the statement that a substantial part of Elena Garro’s unedited memoirs are found inserted in her daughter’s (Helena Paz’s Memoirs. Arguments for such an assertion are presented, together with the excerpts which would correspond more to the experiences of the mother than to those of the daughter.

  14. Revelaciones: los textos fotográficos de Elena Poniatowska

    OpenAIRE

    Camacho de Schmidt, Aurora

    2008-01-01

    Indagación en la simbiosis entre palabra y fotografía en la obra de Elena Poniatowska, como integración de la imagen en la literatura testimonial. A look at the symbiosis of the word and photography in the works of Elena Poniatowska as the integration of the image in testimonial literature.

  15. Living in the spotlight

    CERN Multimedia

    2009-01-01

    Just a few weeks ago, we celebrated the 20th anniversary of the World Wide Web. It gave me my first opportunity since taking up my mandate to see first hand what CERN’s newfound public profile means in practice. There were over 60 media from around the world present at CERN for the event, and some 900 reports in the media over the following days. Some weeks before, Sony pictures held a press event for their upcoming movie, Angels and Demons, part of which takes place at CERN. That happened during the same week that we published the new LHC schedule, and it was the LHC that got the most media coverage. So what does this mean for how we carry out our daily work? Particle physics has always operated in a fully open and transparent way. It’s in our DNA to do so. Meetings are open to all comers, and it is important that we continue to foster such a culture of transparency. Nevertheless, we need to be aware that we are much more in the public spotlight than ever before....

  16. The AD and ELENA orbit, trajectory and intensity measurement systems

    Science.gov (United States)

    Marco-Hernández, R.; Alves, D.; Angoletta, M. E.; Marqversen, O.; Molendijk, J.; Oponowicz, E.; Ruffieux, R.; Sánchez-Quesada, J.; SØby, L.

    2017-07-01

    This paper describes the new Antiproton Decelerator (AD) orbit measurement system and the Extra Low ENergy Antiproton ring (ELENA) orbit, trajectory and intensity measurement system. The AD machine at European Organization for Nuclear Research (CERN) is presently being used to decelerate antiprotons from 3.57 GeV/c to 100 MeV/c for matter vs anti-matter comparative studies. The ELENA machine, presently under commissioning, has been designed to provide an extra deceleration stage down to 13.7 MeV/c. The AD orbit system is based on 32 horizontal and 27 vertical electrostatic Beam Position Monitor (BPM) fitted with existing low noise front-end amplifiers while the ELENA system consists of 24 \\gls{BPM}s equipped with new low-noise head amplifiers. In both systems the front-end amplifiers generate a difference (delta) and a sum (sigma) signal which are sent to the digital acquisition system, placed tens of meters away from the AD or ELENA rings, where they are digitized and further processed. The beam position is calculated by dividing the difference signal by the sum signal either using directly the raw digitized data for measuring the turn-by-turn trajectory in the ELENA system or after down-mixing the signals to baseband for the orbit measurement in both machines. The digitized sigma signal will be used in the ELENA system to calculate the bunched beam intensity and the Schottky parameters with coasting beam after passing through different signal processing chain. The digital acquisition arrangement for both systems is based on the same hardware, also used in the ELENA Low Level Radio Frequency (LLRF) system, which follows the VME Switched Serial (VXS) enhancement of the Versa Module Eurocard 64x extension (VME64x) standard and includes VITA 57 standard Field Programmable Gate Array Mezzanine Card (FMC). The digital acquisition Field Programmable Gate Array (FPGA) and Digital Signal Processor (DSP) firmware shares many common functionalities with the LLRF system but

  17. Santa Elena. Ready to reshape its transport energy matrix

    Energy Technology Data Exchange (ETDEWEB)

    Moreano, Hernan [Universidad Estatal Peninsula de Santa Elena (Ecuador). Inst. de Investigacion Cientifica y Desarrollo Tecnologico (INCYT)

    2012-07-01

    The renewable energy issue opens the door to an ambient of opportunities. Santa Elena, one of the coastal provinces of Ecuador has the chance to go from a fossil fuel energy culture to a new energy scheme based on the use of environmental friendly fuels like natural gas and other renewable energy carriers like hydrogen. The marginal production of oil and natural gas from the Gustavo Galindo Velasco field and the updated gas reserves from the Gulf of Guayaquil make it possible. Infrastructure for natural gas production and distribution for vehicles is almost ready and any of the three refineries can generate hydrogen from natural gas. This provides the opportunity to reshape the Santa Elena transport energy matrix, where vehicles can burn natural gas and inter country buses can work with hydrogen. Traditional Fishing boats can be fitted with hydrogen storage and fuel systems later on. Santa Elena should face this challenge through a joint effort of public and private parties. Santa Elena State University and its partners as a focus point to create: The Campus of Energy Knowledge, where research, science and technology will serve companies that work in the energy business with a strong synergy, which will create jobs for the Santa Elena people. (orig.)

  18. ELENA prepares a bright future for antimatter research

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    At its recent session in June, the CERN Council approved the construction of the Extra Low ENergy Antiproton ring (ELENA) – an upgrade of the existing Antiproton Decelerator. ELENA will allow the further deceleration of antiprotons, resulting in an increased number of particles trapped downstream in the experimental set-ups. This will give an important boost to antimatter research in the years to come.   Layout of the AD experimental hall: the Antiproton Decelerator ring (purple); the ALPHA, ASACUSA, and ATRAP experiments (green); the ACE experiment (not pictured); and the new ELENA ring (blue). The Antiproton Decelerator (AD) is CERN’s widely recognized facility for the study of antimatter properties. The recent successes of the AD experiments are just the latest in a long list of important scientific results that started with LEAR (Low Energy Antiproton Ring). The scientific demand for low-energy antiprotons at the AD continues to grow. There are now four experiments runnin...

  19. Concept for ELENA Extraction and Beam Transfer Elements

    CERN Document Server

    Borburgh, J; Balhan, B; Barna, D; Bartmann, W; Fowler, T; Pricop, V; Sermeus, L; Vanbavinckhove, G

    2013-01-01

    In 2011 the ELENA decelerator was approved as a CERN project. Initially one extraction was foreseen, which should use a kicker and a magnetic septum which can be recuperated from an earlier installation. Since then a second extraction has been approved and a new solution was studied using only electric fields to extract the beam. This will be achieved by fast pulsing a separator, allowing single-bunch but also a full single-turn extraction from ELENA towards the experiments. The extraction and transfer requirements of ELENA are described, followed by the principal differences between the magnetic and electric field concepts. The design of electrostatic focussing and bending devices for the transfer lines will be presented. Finally the field quality which can be achieved with the separator and the concept of its power supply will be discussed.

  20. CERN Antiproton Decelerator Beam Instrumentation for the ELENA era

    CERN Document Server

    Ludwig, M; Gasior, M; Søby, L; Tranquille, G; Fernandes, M

    2014-01-01

    CERN is currently constructing an Extra Low ENergy Antiproton ring (ELENA), which will allow the further deceleration of antiprotons from the currently exploited Antiproton Decelerator (AD). In order to meet the challenges of ELENA the beam instrumentation systems of the CERN AD are being consolidated and upgraded. An updated controls architecture with a more flexible timing system needs to be adopted and obsolete systems must be replaced. This paper presents the status and plans for improved performance and measurement availability of the AD beam instrumentation with a decreased risk of failure.

  1. Geometry and Optics of the Electrostatic ELENA Transfer Lines

    CERN Document Server

    Vanbavinckhove, G; Barna, D; Bartmann, W; Butin, F; Choisnet, O; Yamada, H

    2013-01-01

    The future ELENA ring at CERN will decelerate the AD anti-proton beam further from 5.3 MeV to 100 keV kinetic energy, to increase the efficiency of anti-proton trapping. At present there are four experiments in the AD hall which will be complemented with the installation of ELENA by additional three experiments and an additional source for commissioning. This paper describes the optimization of the transfer line geometry, ring rotation and source position. The optics of the transfer lines and error studies to define field and alignment tolerances are shown, and the optics particularities of electrostatic elements and their optimization highlighted.

  2. Personajes y escenarios en las performances de Elena Tejada

    OpenAIRE

    Mendoza, Mihaela Radulescu de Barrio de

    2017-01-01

    The paper focuses on the enunciative aspects of the art performances of the Peruvian artist Elena Tejada to deepen the effects of meaning generated by the theatrical performance. The construction of characters and scenarios provides the necessary contents for the rituals of integration of the public in the symbolic experience that the performances generate info:eu-repo/semantics/publishedVersion

  3. Pilots with mobile game ‘ELENA goes shopping’

    NARCIS (Netherlands)

    Rusman, Ellen; Ternier, Stefaan

    2014-01-01

    Within the ELENA mobile game pilots we explored the functionality that a mobile phone offers to familiarize children (6-8 years) with a neighbouring, unfamiliar language (German) in a ‘real world context’, in an interactive, playful and independent way, outside the classroom. Another

  4. ELENA from the first ideas to the project

    CERN Document Server

    Tranquille, G; Eriksson, T; Maury, S; Oelert, W

    2013-01-01

    Successful commissioning of the CERN Antiproton Decelerator (AD) in 2000 was followed by significant progress in the creation of anti-hydrogen atoms. The extraction energy of the decelerated antiprotons is nevertheless very high compared to that required by the experiments and results in a trapping efficiency of only 0.1% to 3%. To improve this value by an order of magnitude the study of an Extra Low ENergy Antiproton ring (ELENA) started in 2003 and was approved as a CERN construction project in 2011. During these years the choice of the main machine parameters such as the beam extraction energy, emittance and bunch length were defined, taking into account requests from the physics community. The main challenges were also identified, such as dealing with the large space charge tune, the ultra- high vacuum required and the tight requirements for the electron cooler. Housing the ELENA ring within the AD hall ...

  5. Sfera Politicii's Archive - Elena Ceausescu in the records

    Directory of Open Access Journals (Sweden)

    Stelian Tănase

    2011-10-01

    Full Text Available I don’t know why the idea that Elena Ceauşescu was the key element of her husband’s regime slowly stared to take shape. It is said that by growing older he started to lose his capacity of taking decisions, so he was more and more dependent on her. The idea is credited by a serious number of historians. However, this is a false perspective.

  6. ELENA: From the first ideas to the project

    CERN Document Server

    Tranquille, G; Eriksson, T; Maury, S; Oelert, W

    2012-01-01

    Successful commissioning of the CERN Antiproton Decelerator (AD) in 2000 was followed by significant progress in the creation of anti-hydrogen atoms. The extraction energy of the decelerated antiprotons is nevertheless very high compared to that required by the experiments and results in a trapping efficiency of only 0.1% to 3%. To improve this value by an order of magnitude the study of an Extra Low ENergy Antiproton ring (ELENA) started in 2003 and was approved as a CERN construction project in 2011. During these years the choice of the main machine parameters such as the beam extraction energy, emittance and bunch length were defined, taking into account requests from the physics community. The main challenges were also identified, such as dealing with the large space charge tune, the ultra-high vacuum required and the tight requirements for the electron cooler. Housing the ELENA ring within the AD hall significantly reduced the project cost as well as simplifying the beam transfer from AD to ELENA and fro...

  7. Unlocking investment in cities: ELENA-EIB technical assistance facility

    International Nuclear Information System (INIS)

    Cicmanova, Jana; Garabetian, Thomas

    2015-06-01

    Energy Cities prepared a review of projects undertaken in the cities of Paris, Malmoe (in association with Lund and Helsingborg), Barcelona, Bristol and Brussels-Capital that received support from the ELENA-EIB facility. The aim of this study is to identify the ways in which technical assistance programs such as ELENA-EIB can help unlock investment in cities. The projects we reviewed (developed by Energy Cities' members) cover a wide array of sectors, from public building refurbishment to public transport or renewable energy production. These five projects illustrate how cities can focus on developing capacity in a long-term perspective, looking at the expected benefits of an investment or a support mechanism beyond that of the project itself. Overall, we found that project development assistance mechanisms such as ELENA can be beneficial to trigger investment for climate action in cities. Cities maximise the benefits of such a program by looking at how their climate-protection actions can generate benefits for the citizens, or how to systematically integrate climate action in other investment projects. Project development assistance (PDA) affects cities by allowing them to develop a new vision of the way they prepare an investment program. The search of synergies and the override of silo mentalities were a core element in the projects we reviewed. Indeed, the support provided by the European Union through ELENA-EIB is used by the local authorities to develop a transversal approach to climate action. The grant provided for PDA and the requirements of the ELENA-EIB facility represent an opportunity for local authorities to set up a new strategy regarding energy efficiency and renewable energy actions. It can be the necessary push for cities and local authorities to change the way they plan their investments, and develop projects to achieve their climate objectives. Besides, the grant is used for building long-term capacity in the development of investment

  8. Elena: A case of dissociative identity disorder from the 1920s.

    Science.gov (United States)

    Schimmenti, Adriano

    2017-01-01

    In 1930, Italian psychiatrist Giovanni Enrico Morselli described the history, diagnosis, and treatment of his patient Elena. The case of Elena has been considered in literature as one of the most remarkable cases of multiple personality ever published. In fact, before treatment, Elena showed alternating French- and Italian-speaking personalities, with the Italian personality knowing nothing of her French counterparts. After a difficult treatment involving recovered memories of incestuous attacks by her father, which were proven to be true, Elena fully recovered from her symptoms. In this article, the author presents details of the case that were not available in the international literature before. He also discusses Elena's psychological and somatoform symptoms according to a contemporary perspective on the relationally traumatic origins of dissociation and dissociative identity disorder.

  9. ELENA – An Updated Cost and Feasibility Study

    CERN Document Server

    Angoletta, M-E; Borburgh, J; Breuker, H; Buzio, M; Capatina, O; Chiggiato, P; Ducimetière, L; Eriksson, T; Fowler, T; Hori, M; Lacroix, J-M; LeGodec, G; Lelong, P; Maury, S; Möhl, D; Newborough, A; Nisbet, D; Oelert, W; Pasinelli, S; Puccio, B; Sermeus, L; Soby, L; Tommasini, D; Tranquille, G; Vorozhtsov, A

    2010-01-01

    To produce dense antiproton beams at very low energies (100 keV), it has been proposed to install a small decelerator ring between the existing AD ring and the experimental area. Phase-space blowup during deceleration is compensated by electron cooling such that the final emittances are comparable to the 5MeV beam presently delivered by the AD. An immediate consequence is a significant increase in the number of trapped antiprotons at the experiments as outlined in the proposal CERN/SPSC-2009-026; SPSC-P-338. This report describes the machine parameters and layout of the proposed ELENA (Extra Low ENergy Antiproton) ring and also gives an approximate estimate of cost and manpower needs. Since the initial estimate, published in 2007 (CERN-AB-2007-079), the ELENA design has evolved considerably. This is due to a new location in the AD hall to accommodate for the possibility of another experimental zone, as suggested by the SPSC, and also due to improvements in the ring optics and layout. The cost estimate that is...

  10. Holding a spotlight to an ageing society.

    Science.gov (United States)

    Cann, Paul

    2008-07-01

    In May 2008 Help the Aged published its 3rd annual Spotlight Report. The report highlights the stark realities facing older people in the UK today and gives detailed statistical data on how the lives of some have improved but many are still being left behind.

  11. Elena Guardincerri: Tracking muons to reduce nuclear threats and help preserve architectural treasures

    Energy Technology Data Exchange (ETDEWEB)

    Del Mauro, Diana [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Guardincerri, Elena [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-29

    When Elena Guardincerri was a physics PhD student at the University of Genova, she considered muons a nuisance. She built muon detectors to snare these secondary cosmic rays, which were interfering with her experiments to study elusive neutrinos.

  12. Elena Natale ja Mikko Fritze: kultuuripealinna tiimi motivatsioon on töö ise / Elena Natale, Mikko Fritze ; intervjueerinud Tiina Saar

    Index Scriptorium Estoniae

    Natale, Elena

    2009-01-01

    SA Tallinn 2011 tegevjuht Mikko Fritze ja administratiivjuht Elena Natale vastavad küsimustele, mis puudutavad Eesti töökultuuri, , toimiva koostöö saavutamist meeskonnas, kasutatavaid motivatsiooni- ja juhtimissüsteeme, personalivalikut, majanduskriisi mõju SA Tallinn 2011 tegevusele

  13. Efficient sliding spotlight SAR raw signal simulation of extended scenes

    Directory of Open Access Journals (Sweden)

    Huang Pingping

    2011-01-01

    Full Text Available Abstract Sliding spotlight mode is a novel synthetic aperture radar (SAR imaging scheme with an achieved azimuth resolution better than stripmap mode and ground coverage larger than spotlight configuration. However, its raw signal simulation of extended scenes may not be efficiently implemented in the two-dimensional (2D Fourier transformed domain. This article presents a novel sliding spotlight raw signal simulation approach from the wide-beam SAR imaging modes. This approach can generate sliding spotlight raw signal not only from raw data evaluated by the simulators, but also from real data in the stripmap/spotlight mode. In order to obtain the desired raw data from conventional stripmap/spotlight mode, the azimuth time-varying filtering, which is implemented by de-rotation and low-pass filtering, is adopted. As raw signal of extended scenes in the stripmap/spotlight mode can efficiently be evaluated in the 2D Fourier domain, the proposed approach provides an efficient sliding spotlight SAR simulator of extended scenes. Simulation results validate this efficient simulator.

  14. Sliding Spotlight Mode Imaging with GF-3 Spaceborne SAR Sensor

    Directory of Open Access Journals (Sweden)

    Qingjun Zhang

    2017-12-01

    Full Text Available Synthetic aperture radar (SAR sliding spotlight work mode can achieve high resolutions and wide swath (HRWS simultaneously by steering the radar antenna beam. This paper aims to obtain well focused images using sliding spotlight mode with the Chinese Gaofen-3 SAR sensor. We proposed an integrated imaging scheme with sliding spotlight echoes. In the imaging scheme, the two-step approach is applied to the spaceborne sliding spotlight SAR imaging algorithm, followed by the Doppler parameter estimation algorithm. The azimuth spectral folding phenomenon is overcome by the two-step approach. The results demonstrate a high Doppler parameter estimation accuracy. The proposed imaging process is accurate and highly efficient for sliding spotlight SAR mode.

  15. Spotlight on GME/GHSE Supported Research

    Science.gov (United States)

    2017-12-07

    REPORT TYPE 3. DATES COVERED (From- To) 12/07/2017 Poster 4. TITLE AND SUBTITLE Sa. CONTRACT NUMBER Spotlight on GME/GHSE-Supported Research Sb...ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION 59th Clinical Research Division REPORT NUMBER 1100 Willford Hall Loop, Bldg 4430 JBSA... Research Division 1100 Willford Hall Loop, Bldg 4430 JBSA-Lack:land, TX 78236-9908 11. SPONSOR/MONITOR’S REPORT 210-292-7141 NUMBER(S) 12

  16. Extra Low Energy Antiproton ring ELENA : from the conception to the implementation phase

    CERN Document Server

    Bartmann, W; Breuker, H; Butin, F; Carli, C; Eriksson, T; Maury, S; Pasinelli, S; Tranquille, G; Oelert, W

    2014-01-01

    The Extra Low Energy Antiproton ring (ELENA) is a CERN project aiming at constructing a small 30 m circumference synchrotron to further decelerate antiprotons from the Antiproton Decelerator AD from 5.3 MeV to 100 keV. Controlled deceleration in a synchrotron equipped with an electron cooler to reduce emittances in all three planes will allow the existing AD experiments to increase substantially their antiproton capture efficiencies and render new experiments possible. The ELENA design is now well advanced and the project is moving to the implementation phase. Component design and construction are taking place at present for installation foreseen during the second half of 2015 and beginning of 2016 followed by ring commissioning until the end of 2016. New electrostatic transfer lines to the experiments will be installed and commissioned during the first half of 2017 followed by the first physics operation with ELENA. Basic limitations like Intra Beam Scattering limiting the emittances obtained under electron ...

  17. Nuclear Fuels & Materials Spotlight Volume 4

    Energy Technology Data Exchange (ETDEWEB)

    I. J. van Rooyen,; T. M. Lillo; Y. Q. WU; P.A. Demkowicz; L. Scott; D.M. Scates; E. L. Reber; J. H. Jackson; J. A. Smith; D.L. Cottle; B.H. Rabin; M.R. Tonks; S.B. Biner; Y. Zhang; R.L. Williamson; S.R. Novascone; B.W. Spencer; J.D. Hales; D.R. Gaston; C.J. Permann; D. Anders; S.L. Hayes; P.C. Millett; D. Andersson; C. Stanek; R. Ali; S.L. Garrett; J.E. Daw; J.L. Rempe; J. Palmer; B. Tittmann; B. Reinhardt; G. Kohse; P. Ramuhali; H.T. Chien; T. Unruh; B.M. Chase; D.W. Nigg; G. Imel; J. T. Harris

    2014-04-01

    As the nation's nuclear energy laboratory, Idaho National Laboratory brings together talented people and specialized nuclear research capability to accomplish our mission. This edition of the Nuclear Fuels and Materials Division Spotlight provides an overview of some of our recent accomplishments in research and capability development. These accomplishments include: • The first identification of silver and palladium migrating through the SiC layer in TRISO fuel • A description of irradiation assisted stress corrosion testing capabilities that support commercial light water reactor life extension • Results of high-temperature safety testing on coated particle fuels irradiated in the ATR • New methods for testing the integrity of irradiated plate-type reactor fuel • Description of a 'Smart Fuel' concept that wirelessly provides real time information about changes in nuclear fuel properties and operating conditions • Development and testing of ultrasonic transducers and real-time flux sensors for use inside reactor cores, and • An example of a capsule irradiation test. Throughout Spotlight, you'll find examples of productive partnerships with academia, industry, and government agencies that deliver high-impact outcomes. The work conducted at Idaho National Laboratory helps to spur innovation in nuclear energy applications that drive economic growth and energy security. We appreciate your interest in our work here at INL, and hope that you find this issue informative.

  18. Field Simulations and Mechanical Implementation of Electrostatic Elements for the ELENA Transfer Lines

    CERN Document Server

    Barna, D; Borburgh, J; Carli, C; Vanbavinckhove, G

    2014-01-01

    The Antiproton Decelerator (AD) complex at CERN will be extended by an extra low energy anti-proton ring (ELENA) [1] further decelerating the anti-protons thus improving their trapping. The kinetic energy of 100 keV at ELENA extraction facilitates the use of electrostatic transfer lines to the experiments. The mechanical implementation of the electrostatic devices are presented with focus on their alignment, bakeout compatibility, ultra-high vacuum compatibility and polarity switching. Field optimisations for an electrostatic crossing device of three beam lines are shown.

  19. Spotlight on Psoriasis: Preventing Patches of Itchy, Sore Skin

    Science.gov (United States)

    ... Subscribe August 2016 Print this issue Spotlight on Psoriasis Preventing Patches of Itchy, Sore Skin En español ... Sun Damage Sun and Skin Wise Choices Avoid Psoriasis Triggers Factors that may trigger psoriasis or make ...

  20. Nuclear Fuels & Materials Spotlight Volume 5

    Energy Technology Data Exchange (ETDEWEB)

    Petti, David Andrew [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-10-01

    As the nation's nuclear energy laboratory, Idaho National Laboratory brings together talented people and specialized nuclear research capability to accomplish our mission. This edition of the Nuclear Fuels and Materials Division Spotlight provides an overview of some of our recent accomplishments in research and capability development. These accomplishments include: • Evaluation and modeling of light water reactor accident tolerant fuel concepts • Status and results of recent TRISO-coated particle fuel irradiations, post-irradiation examinations, high-temperature safety testing to demonstrate the accident performance of this fuel system, and advanced microscopy to improve the understanding of fission product transport in this fuel system. • Improvements in and applications of meso and engineering scale modeling of light water reactor fuel behavior under a range of operating conditions and postulated accidents (e.g., power ramping, loss of coolant accident, and reactivity initiated accidents) using the MARMOT and BISON codes. • Novel measurements of the properties of nuclear (actinide) materials under extreme conditions, (e.g. high pressure, low/high temperatures, high magnetic field) to improve the scientific understanding of these materials. • Modeling reactor pressure vessel behavior using the GRIZZLY code. • New methods using sound to sense temperature inside a reactor core. • Improved experimental capabilities to study the response of fusion reactor materials to a tritium plasma. Throughout Spotlight, you'll find examples of productive partnerships with academia, industry, and government agencies that deliver high-impact outcomes. The work conducted at Idaho National Laboratory helps spur innovation in nuclear energy applications that drive economic growth and energy security. We appreciate your interest in our work here at Idaho National Laboratory, and hope that you find this issue informative.

  1. Elena Poniatowska y la Generación de Medio Siglo: Lilus, Jesusa, Angelina, Tina ... y la errancia sin fin

    OpenAIRE

    Bruce Novoa, Juan

    2008-01-01

    Estudio que trata de circunscribir la figura de Elena en la relación con sus contemporáneos, con los que coincide en la actitud rebelde e iconoclasta. El sentido documental de la literatura aporta una nueva faceta a la escritura de México. This study is an attempt to define the character of Elena in relation to contemporary rebellious iconoclastic attitudes in other characters. The documentary like style adds a new feature to Mexican writing.

  2. Sotsiaalne kunst kui kodanikuõigus ja -kohustus / Rael Artel, Elena Šmakova

    Index Scriptorium Estoniae

    Artel, Rael, 1980-

    2010-01-01

    Vastukaja: Siram. Kunst, mis ei räägi inimestega (Eesti Ekspress, 2010, 8. apr., lk. 32). Kuraator Rael Artel Kumu Kunstimuuseumis eksponeeritud näitusest "Räägime rahvuslusest! Ideoloogia ja identiteedi vahel", kaasaegse kunsti mõistmisest. Elena Šmakova Rael Arteli kureeritud näitusest ja Tallinna Kunstihoones avatud Kristina Normani isikunäitusest "Me ei ole universumis üksi", kaasaegse kunsti kohta ilmunud kriitilistest artiklitest

  3. Longitudinal beam diagnostic from a distributed electrostatic pick-up in CERN's ELENA ring

    CERN Document Server

    Angoletta, M E; Federmann, S; Molendijk, J; Sanchez-Quesada, J; Secouet, P J; Søby, L; Pedersen, F; Timmins, M

    2013-01-01

    The CERN Extra Low ENergy Antiproton (ELENA) Ring is a new synchrotron that will be commissioned in 2016 to further decelerate the antiprotons coming from CERN’s Antiproton Decelerator (AD). Required longitudinal diagnostics include the intensity measurement for bunched and debunched beam and the measurement of Dp/p to assess the electron cooling performance. A novel method for the calculation of these parameters is proposed for ELENA, where signals from the twenty electrostatic Pick-Ups (PU) used for orbit measurements will be combined to improve the signal-to-noise ratio. This requires that the signals be digitally down-converted, rotated and summed so that the many electrostatic PUs will function as a single, distributed PU from the processing system viewpoint. This method includes some challenges and will not be used as the baseline longitudinal diagnostics for the initial ELENA operation. This paper gives an overview of the hardware and digital signal processing involved, as well as of the challenges t...

  4. Vulnerabilidades frente amenazas naturales en establecimientos de salud de la Provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Bertha De Monserrate

    2015-10-01

    Full Text Available Un equipo de análisis de riesgos de la Universidad Estatal Península de Santa Elena y Cooperazione Internationale durante el año 2010, llevó a cabo un estudio de vulnerabilidad de los establecimientos de salud de la provincia de Santa Elena frente a amenazas naturales de tsunami, inundación, erosión y movimiento en masa. El objetivo: evaluar los establecimientos de salud por tipos y nivel de atención, mediante la aplicación de los estándares establecidos en el Manual de Licenciamiento de Ministerio de Salud Pública y diagnosticar el grado de vulnerabilidad de la ubicación geográfica de los establecimientos de salud frente a las amenazas naturales, mediante la superposición de mapas de distribución geográfica y los mapas preliminares de amenazas a desastres naturales de la Secretaria General de Riesgos definida desde las amenazas en base a la guía para implementar el análisis de vulnerabilidades a nivel cantonal de esta secretaría. Resultados: la provincia de Santa Elena cuenta con 75 unidades de salud, 29 pertenecen al Ministerio de Salud Pública y 46 a Organizaciones no gubernamentales, el 75% brindan atención de primer nivel y el 25% segundo nivel básico. El estudio de vulnerabilidad mostró que el hospital de Manglaralto, los subcentros de San Francisco de las Núñez, San Pablo, Monteverde y el dispensario de la Superintendencia de la Libertad califican muy alto, mientras que el resto se considera de alto a medio. El Ministerio de Salud Pública debe reubicar aquellos establecimientos calificados como muy alto y alto.

  5. Composición del plancton en la Puntilla Santa Elena durante agosto 2002 (Ecuador)

    OpenAIRE

    Torres, G.; Calderón, G.; Franco, V.; Cedeño, E.; Calderón, T.; Salazar, E.

    2004-01-01

    Esta investigación comprende los estudios del fitoplancton-zooplancton-ictioplancton, realizados en tres sitios de la Península Santa Elena durante agosto 2002, área designada para la proyección de "Arrecife Artificial de las Fuerzas Militares del Ecuador": un avión, barco y tanque de guerra, estructuras artificiales consideradas como basura chatarra (de gran tamaño), que serían recicladas para la bio-exploración artificiales hacia la seguridad de los recursos marinos del Ecuador. En el Estud...

  6. [Elena de Cespedes: The eventful life of a XVI century surgeon].

    Science.gov (United States)

    Carrillo Esper, Raúl; Carrillo Córdova, Jorge Raúl; Carrillo Córdova, Luis Daniel; Carrillo Córdova, Dulce María; Carrillo Córdova, Carlos Alberto

    2015-01-01

    Throughout the history of surgery there have been exceptional cases of surgeons around the world. One of them is Elena/o of Cespedes. Born as a girl, this hermaphrodite dedicated all his life to acting as a man, doing jobs that were only for men such as a soldier, peasant, and surgeon. She was the first licensed surgeon in Spain and maybe in all Europe. She married a woman and then was tried for sodomy by the Spanish Inquisition commanded by inquisitor Lope de Mendoza. She was founded guilty and punished with 200 lashes and a 10-year service at a hospital, dressed as a woman.

  7. New findings of Pleistocene fossil turtles (Geoemydidae, Kinosternidae and Chelydridae from Santa Elena Province, Ecuador

    Directory of Open Access Journals (Sweden)

    Edwin A. Cadena

    2017-04-01

    Full Text Available New Pleistocene fossilized turtle remains from five localities of western Ecuador (Santa Elena Province are described here. All these shell (carapace and plastron fossil remains come from the Tablazo Formation and belong to three different lineages of cryptodires (“hidden-necked” turtles. The most abundant remains belong to geoemydids, attributed here to the genus Rhinoclemmys (indeterminate species. Less abundant in occurrence are the kinosternidids, attributed to Kinosternon (indeterminate species, and the first fossil record of chelydrids, Chelydra(indeterminate species, in the entirety of Central and South America.

  8. Angelina Beloff y Leonora Carrington bajo la mirada de Elena Poniatowska

    OpenAIRE

    Gras Cruz, Irene

    2015-01-01

    El presente estudio se centra en la mirada que otorga una de las grandes escritoras de nuestros tiempos, la mexicana Elena Poniatowska (París, 1932), a artistas como la pintora y grabadora rusa Angelina Petrovna Belova, llamada comúnmente Angelina Beloff (1879-1969), a quien le dedica su novela Querido Diego, te abraza Quiela (1978) o a la pintora surrealista y escritora inglesa Leonora Carrington (1917-2011) con su Leonora (2011). Mujeres que comparten un destino común, México, tierra de luz...

  9. Research on Synthetic Aperture Radar Processing for the Spaceborne Sliding Spotlight Mode

    OpenAIRE

    Shijian Shen; Xin Nie; Xinggan Zhang

    2018-01-01

    Gaofen-3 (GF-3) is China’ first C-band multi-polarization synthetic aperture radar (SAR) satellite, which also provides the sliding spotlight mode for the first time. Sliding-spotlight mode is a novel mode to realize imaging with not only high resolution, but also wide swath. Several key technologies for sliding spotlight mode in spaceborne SAR with high resolution are investigated in this paper, mainly including the imaging parameters, the methods of velocity estimation and ambiguity elimina...

  10. 'ELENA goes mobile': a mobile assisted early foreign language learning pilot for familiarizing children with neighbouring languages

    OpenAIRE

    Rusman, Ellen; Ternier, Stefaan; Sassen, Derk

    2013-01-01

    Rusman, E., Ternier, S., & Sassen, D. (2013, 14-15 November). 'ELENA goes mobile': a mobile assisted early foreign language learning pilot for familiarizing children with neighbouring languages. Presentation (virtual) at the 6th ICT for Language learning Conference, Florence, Italy. (URL of virtual presentation, including audio, will follow).

  11. 'ELENA goes mobile': a mobile assisted early foreign language learning pilot for familiarizing children with neighbouring languages

    NARCIS (Netherlands)

    Rusman, Ellen; Ternier, Stefaan; Sassen, Derk

    2013-01-01

    Rusman, E., Ternier, S., & Sassen, D. (2013, 14-15 November). 'ELENA goes mobile': a mobile assisted early foreign language learning pilot for familiarizing children with neighbouring languages. Presentation (virtual) at the 6th ICT for Language learning Conference, Florence, Italy. (URL of virtual

  12. The Financial Management System: A Pivotal Tool for Fiscal Viability. CDS Spotlight. ECAR Research Bulletin

    Science.gov (United States)

    Lang, Leah; Pirani, Judith A.

    2014-01-01

    This spotlight focuses on data from the 2013 CDS to better understand how higher education institutions approach financial management systems. Information provided for this spotlight was derived from Module 8 of Core Data Service (CDS), which asked several questions regarding information systems and applications. Responses from 525 institutions…

  13. BI Reporting, Data Warehouse Systems, and Beyond. CDS Spotlight Report. Research Bulletin

    Science.gov (United States)

    Lang, Leah; Pirani, Judith A.

    2014-01-01

    This Spotlight focuses on data from the 2013 Core Data Service [CDS] to better understand how higher education institutions approach business intelligence (BI) reporting and data warehouse systems (see the Sidebar for definitions). Information provided for this Spotlight was derived from Module 8 of CDS, which contains several questions regarding…

  14. Maximize Institutional Relationships with CRMs. CDS Spotlight Report. ECAR Research Bulletin

    Science.gov (United States)

    Lang, Leah; Pirani, Judith A.

    2014-01-01

    This Spotlight focuses on data from the 2013 Core Data Service (CDS) to better understand how higher education institutions approach customer relationship management (CRM) systems. Information provided for this Spotlight was derived from Module 8 of the Core Data survey, which asked several questions regarding information systems and applications.…

  15. ELENA MODENA, L'altrOrfeo. Considerazioni analitiche sulla vocalità, Roma, Aracne, 2009

    Directory of Open Access Journals (Sweden)

    Adriana Guarnieri

    2012-11-01

    Full Text Available Il volume propone un’indagine sulla vocalità ispirata al «metodo funzionale della voce» di Gisela Rohmert, didatta e fondatrice del Lichtenberger Institut für angewandte Stimmphysiologie, attivo in Germania dal 1982 . Da quell'esperienza – un metodo di pedagogia della voce fondato sullo studio della fisiologia vocale e del «fatto vocale» in quanto evento acustico e stimolo percettivo – Elena Modena ha derivato e illustra in questo libro una sua proposta di «analisi funzionale» della vocalità, storicamente considerata e rivolta, insieme, all’àmbito dell’emissione e a quello dell’ascolto.

  16. AEgIS at ELENA: outlook for physics with a pulsed cold antihydrogen beam

    Science.gov (United States)

    Doser, M.; Aghion, S.; Amsler, C.; Bonomi, G.; Brusa, R. S.; Caccia, M.; Caravita, R.; Castelli, F.; Cerchiari, G.; Comparat, D.; Consolati, G.; Demetrio, A.; Di Noto, L.; Evans, C.; Fanì, M.; Ferragut, R.; Fesel, J.; Fontana, A.; Gerber, S.; Giammarchi, M.; Gligorova, A.; Guatieri, F.; Haider, S.; Hinterberger, A.; Holmestad, H.; Kellerbauer, A.; Khalidova, O.; Krasnický, D.; Lagomarsino, V.; Lansonneur, P.; Lebrun, P.; Malbrunot, C.; Mariazzi, S.; Marton, J.; Matveev, V.; Mazzotta, Z.; Müller, S. R.; Nebbia, G.; Nedelec, P.; Oberthaler, M.; Pacifico, N.; Pagano, D.; Penasa, L.; Petracek, V.; Prelz, F.; Prevedelli, M.; Rienaecker, B.; Robert, J.; Røhne, O. M.; Rotondi, A.; Sandaker, H.; Santoro, R.; Smestad, L.; Sorrentino, F.; Testera, G.; Tietje, I. C.; Widmann, E.; Yzombard, P.; Zimmer, C.; Zmeskal, J.; Zurlo, N.

    2018-03-01

    The efficient production of cold antihydrogen atoms in particle traps at CERN's Antiproton Decelerator has opened up the possibility of performing direct measurements of the Earth's gravitational acceleration on purely antimatter bodies. The goal of the AEgIS collaboration is to measure the value of g for antimatter using a pulsed source of cold antihydrogen and a Moiré deflectometer/Talbot-Lau interferometer. The same antihydrogen beam is also very well suited to measuring precisely the ground-state hyperfine splitting of the anti-atom. The antihydrogen formation mechanism chosen by AEgIS is resonant charge exchange between cold antiprotons and Rydberg positronium. A series of technical developments regarding positrons and positronium (Ps formation in a dedicated room-temperature target, spectroscopy of the n=1-3 and n=3-15 transitions in Ps, Ps formation in a target at 10 K inside the 1 T magnetic field of the experiment) as well as antiprotons (high-efficiency trapping of ?, radial compression to sub-millimetre radii of mixed ? plasmas in 1 T field, high-efficiency transfer of ? to the antihydrogen production trap using an in-flight launch and recapture procedure) were successfully implemented. Two further critical steps that are germane mainly to charge exchange formation of antihydrogen-cooling of antiprotons and formation of a beam of antihydrogen-are being addressed in parallel. The coming of ELENA will allow, in the very near future, the number of trappable antiprotons to be increased by more than a factor of 50. For the antihydrogen production scheme chosen by AEgIS, this will be reflected in a corresponding increase of produced antihydrogen atoms, leading to a significant reduction of measurement times and providing a path towards high-precision measurements. This article is part of the Theo Murphy meeting issue `Antiproton physics in the ELENA era'.

  17. Research Skills for the Future: Research Workforce Under the Spotlight

    Directory of Open Access Journals (Sweden)

    Eva Dobozy

    2013-01-01

    Full Text Available The value and training needs of the future research workforce is under the spotlight. In this article, I take up Ulrich and Dash's (2013 somewhat provocative invitation to engage in discussion and debate about current and future research. In my three-tiered response, I first discuss Ulrich and Dash's article, followed by my own observations about the APEC/Deloitte (2010 research report: "Skills and Competencies Needed in the Research Field: Objectives 2020," and finally, I explore, in some detail, challenges of building a twentyfirst-century research workforce.

  18. Kogesime suurepärast meeskonnatööd / Liisi Lembinen, Elena Sipria-Mironov ; intervjueerinud Õnne Mets, Ene Riet

    Index Scriptorium Estoniae

    Lembinen, Liisi

    2014-01-01

    Tartu Ülikooli Raamatukogu osales EOD-projektis 2009. aasta maist kuni 2014. aasta aprillini. Kuidas projekt toimis ja mida saavutati, vastavad direktori kt Liisi Lembinen ja projektijuht Elena Sipria-Mironov

  19. Manual de control interno para el área contable de la empresa industrial Santa Elena S.A. Empindecu, del cantón La Libertad, provincia de Santa Elena, año 2015.

    OpenAIRE

    Carrera Rivera, Stefanía Vanessa

    2015-01-01

    El presente trabajo de investigación previa la obtención del título de Licenciada en Contabilidad y Auditoría, tiene como objetivo primordial evaluar la incidencia de la gestión contable en las políticas y procedimientos, mediante un análisis situacional y la aplicación de técnicas de investigación, direccionados a la elaboración de un manual de control interno para el área contable de la Empresa Industrial Santa Elena S.A. EMPINDECU del cantón La Libertad provincia de Santa Elena. La empresa...

  20. Voicing Others’ Voices: Spotlighting the Researcher as Narrator

    Directory of Open Access Journals (Sweden)

    Dan O’SULLIVAN

    2015-12-01

    Full Text Available As qualitative research undertakings are not independent of the researcher, the “indissoluble interrelationship between interpreter and interpretation” (Thomas & James, 2006, p. 782 renders it necessary for researchers to understand that their text is a representation, a version of the truth that is the product of writerly choices, and that it is discursive. Endlessly creative, artistic and political, as there is no single interpretative truth, the interpretative process facilitates the refashioning of representations, the remaking of choices and the probing of discourses. As a consequence of the particularity of any researcher’s account, issues pertaining to researcher identity and authorial stance always remain central to research endeavours (Kamler & Thomson, 2006, p. 68; Denzin & Lincoln 2011, pp. 14-15. Therefore, researchers are encouraged to be reflexive about their analyses and research accounts (Elliott, 2005, p. 152, as reflexivity helps spotlight the role of the researcher as narrator. In turn, spotlighting the researcher as narrator foregrounds a range of complex issues about voice, representation and interpretive authority (Chase, 2005, p. 657; Genishi & Glupczynski, 2006, p. 671; Eisenhart, 2006. In essence, therefore, this paper is reflective of the challenges of “doing” qualitative research in educational settings. Its particular focus-the shaping of beginning primary teachers’ identities, in Ireland, throughout the course of their initial year of occupational experience, post-graduation- endeavours to highlight issues pertaining to the researcher as narrator (O’Sullivan, 2014.

  1. Spotlighting quantum critical points via quantum correlations at finite temperatures

    International Nuclear Information System (INIS)

    Werlang, T.; Ribeiro, G. A. P.; Rigolin, Gustavo

    2011-01-01

    We extend the program initiated by T. Werlang et al. [Phys. Rev. Lett. 105, 095702 (2010)] in several directions. Firstly, we investigate how useful quantum correlations, such as entanglement and quantum discord, are in the detection of critical points of quantum phase transitions when the system is at finite temperatures. For that purpose we study several thermalized spin models in the thermodynamic limit, namely, the XXZ model, the XY model, and the Ising model, all of which with an external magnetic field. We compare the ability of quantum discord, entanglement, and some thermodynamic quantities to spotlight the quantum critical points for several different temperatures. Secondly, for some models we go beyond nearest neighbors and also study the behavior of entanglement and quantum discord for second nearest neighbors around the critical point at finite temperature. Finally, we furnish a more quantitative description of how good all these quantities are in spotlighting critical points of quantum phase transitions at finite T, bridging the gap between experimental data and those theoretical descriptions solely based on the unattainable absolute zero assumption.

  2. Estrategias de comercialización de las distribuidoras de productos de consumo masivo de la provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Nury Vera Campuzano

    2017-05-01

    The objective of the present scientific article is to diagnose the perception of the consumers of the distributors of products of mass consumption of the province of Santa Elena. The theoretical contribution lies in the conception of theory and practice in strategic marketing actions, taking into account the context, the definition and characterization of marketing management, in order to determine the decisive and success factors for the companies, constitutes the contribution Theoretical to argue the research carried out. An exploratory investigation was conducted for consumers of mass products between 20 and 54 years of Santa Elena province and interviews were conducted with three distributors of mass consumer products. The results recommend that with the application of assertive marketing strategies based on the preferences of the target group, and market trends, organizational performance would be improved by attracting prospects and generating loyalty ties of current clients.

  3. ANÁLISIS DE LAS ESTRUCTURAS DE CAPITAL EN EL ECUADORPÈSQUERO DE LA PROVINCIA DE SANTA ELENA

    OpenAIRE

    González Suárez, Gissel Mariana

    2017-01-01

    El incremento de la capacidad productiva demanda diferentes fuentes de financiamiento ya sea a corto o a largo plazo, el financiamiento con la banca tiene ventajas y desventajas, incluyendo el pago de intereses que reduce la utilidad contable y por ende ayuda a pagar menos impuesto a la renta. La presente investigación buscó analizar las diferentes estructuras de capital que mantienen las empresas de la provincia de Santa Elena, particularmente aquellas cuya actividad principal...

  4. Using frequency-scaling approach to process squint-mode spotlight SAR data

    Science.gov (United States)

    Sun, Jinping; Mao, Shiyi; Liu, Zhongkan; Hong, Wen Q.

    2001-08-01

    Frequency scaling approach is a new spotlight SAR image formation algorithm. It precisely performs the range cell migration correction for dechirped raw data without interpolation by using a novel frequency scaling operation while residual video phase is corrected simultaneously. The computation requirements are lower than the other spotlight SAR image formation approaches such as polar format algorithm and range migration algorithm. In this paper, frequency scaling algorithm is applied to process high squint spotlight data. The new squint illumination geometry is defined and some modifications to the basic algorithm are presented. Point target simulations up to 45 deg squint angle are carried out to show the validity of the algorithm.

  5. AEgIS at ELENA: outlook for physics with a pulsed cold antihydrogen beam.

    Science.gov (United States)

    Doser, M; Aghion, S; Amsler, C; Bonomi, G; Brusa, R S; Caccia, M; Caravita, R; Castelli, F; Cerchiari, G; Comparat, D; Consolati, G; Demetrio, A; Di Noto, L; Evans, C; Fanì, M; Ferragut, R; Fesel, J; Fontana, A; Gerber, S; Giammarchi, M; Gligorova, A; Guatieri, F; Haider, S; Hinterberger, A; Holmestad, H; Kellerbauer, A; Khalidova, O; Krasnický, D; Lagomarsino, V; Lansonneur, P; Lebrun, P; Malbrunot, C; Mariazzi, S; Marton, J; Matveev, V; Mazzotta, Z; Müller, S R; Nebbia, G; Nedelec, P; Oberthaler, M; Pacifico, N; Pagano, D; Penasa, L; Petracek, V; Prelz, F; Prevedelli, M; Rienaecker, B; Robert, J; Røhne, O M; Rotondi, A; Sandaker, H; Santoro, R; Smestad, L; Sorrentino, F; Testera, G; Tietje, I C; Widmann, E; Yzombard, P; Zimmer, C; Zmeskal, J; Zurlo, N

    2018-03-28

    The efficient production of cold antihydrogen atoms in particle traps at CERN's Antiproton Decelerator has opened up the possibility of performing direct measurements of the Earth's gravitational acceleration on purely antimatter bodies. The goal of the AEgIS collaboration is to measure the value of g for antimatter using a pulsed source of cold antihydrogen and a Moiré deflectometer/Talbot-Lau interferometer. The same antihydrogen beam is also very well suited to measuring precisely the ground-state hyperfine splitting of the anti-atom. The antihydrogen formation mechanism chosen by AEgIS is resonant charge exchange between cold antiprotons and Rydberg positronium. A series of technical developments regarding positrons and positronium (Ps formation in a dedicated room-temperature target, spectroscopy of the n =1-3 and n =3-15 transitions in Ps, Ps formation in a target at 10 K inside the 1 T magnetic field of the experiment) as well as antiprotons (high-efficiency trapping of [Formula: see text], radial compression to sub-millimetre radii of mixed [Formula: see text] plasmas in 1 T field, high-efficiency transfer of [Formula: see text] to the antihydrogen production trap using an in-flight launch and recapture procedure) were successfully implemented. Two further critical steps that are germane mainly to charge exchange formation of antihydrogen-cooling of antiprotons and formation of a beam of antihydrogen-are being addressed in parallel. The coming of ELENA will allow, in the very near future, the number of trappable antiprotons to be increased by more than a factor of 50. For the antihydrogen production scheme chosen by AEgIS, this will be reflected in a corresponding increase of produced antihydrogen atoms, leading to a significant reduction of measurement times and providing a path towards high-precision measurements.This article is part of the Theo Murphy meeting issue 'Antiproton physics in the ELENA era'. © 2018 The Author(s).

  6. From Odessa to Florence: Elena Comparetti Raffalovich. A Jewish Russian Woman in Nineteenth-Century Italy

    Directory of Open Access Journals (Sweden)

    Asher Salah

    2015-11-01

    Full Text Available In the nineteenth and the first half of the twentieth century, Italy held a strong appeal for Russian travelers. Several of these Russian émigrés were women of Jewish lineage, who had come with their families or were sent abroad on their own in order to complete their education at one of the newborn kingdom’s prestigious universities. Elena Raffalovich (Odessa 1842 – Florence 1918 is one of the earliest and most intriguing examples of this phenomenon. While her intellectual trajectory, as a pioneer in children’s education and an advocate of women’s rights, is representative of that of many other Russian Jewish women living in Italy at that time, it also challenges a number of historiographic commonplaces about Jewish women and their emancipation process in nineteenth-century Europe. Moreover, through the archives of different prominent members of the Raffalovich dynasty, it is possible to follow its vicissitudes over at least five generations, completing our knowledge of Elena’s biography and reassessing the importance of her intellectual contribution to Italian culture.

  7. Magnetic characterization of ferrite materials used in the ELENA magnetic pick-ups

    CERN Document Server

    Favia, Giorgia; CERN. Geneva. ATS Department

    2015-01-01

    The CERN Extra Low ENergy Antiproton (ELENA) Ring is a new synchrotron designed for cooling and further decelerating the 5.3 MeV antiprotons delivered by the CERN Antiproton Decelerator (AD). The ring is equipped with two magnetic pick-ups used for longitudinal beam diagnostics. These ultra low noise AC beam transformers consist of a doubly shielded, ferrite-loaded cavity with a ceramic gap in the beam pipe, a secondary winding to which an ultralow noise JFET head amplifier with feedback is connected. The JFET head amplifier is mounted close to the cavity and the AC beam transformers are covering respectively the 0.003-3MHz frequency range (low frequency type) and 0.8-30 MHz frequency range (high frequency type) [1]. The ferrite material used to couple primary and secondary in the beam transformer, has a key impact in the noise characteristics of the amplifier. For this reason a magnetic characterization of the selected ferrite rings has been carried out and is reported in the following.

  8. Model of Ecological Connectivity of Andean Forest Fragments in Santa Elena (Medellín, Colombia

    Directory of Open Access Journals (Sweden)

    Gabriel Jaime Colorado Zuluaga

    2017-09-01

    Full Text Available Forest fragmentation and the associated potential habitat loss is one of the main causes of biodiversity loss. One strategy that promotes its maintenance at a landscape scale is the establishment of biological corridors that enhance structural and functional connectivity of the biotic components. However, the applicability and functionality of this tool is limited due to the lack of planning at the moment of the design and establishment of corridors or connectivity networks that are guided by detailed and rigorous methods. In this research, we developed a theoretical proposal of ecological connectivity for the Santa Elena village, Medellin municipality, Colombia, using tools from landscape ecology. Initially, 21 forest fragments or nucleus were selected based on their minimum size (larger than 5 ha, core area (larger than 1 ha, and shape index (rounded or nearly rounded. Then, based on a friction matrix, we designed a potential network that would allow to connect 1356.35 ha of remnants forests through 31 ecological corridors of 100 m wide, comprising 208.33 ha in total. Finally, we discussed the importance of promoting this kind of strategies based on landscape ecology that enhance both habitat conservation and landscape connectivity in areas near large Latin-American cities.

  9. Plan de manejo integral del sitio arqueológico Santa Elena, Tabasco, México

    Directory of Open Access Journals (Sweden)

    Ernesto González Licón

    2013-11-01

    Full Text Available En este artículo se destaca la importancia histórica, cultural y turística del sitio arqueológico de Santa Elena, en el Estado de Tabasco, México. Mediante la ejecución de un proyecto de investigación arqueológica y Plan de Manejo Integral se pretende desarrollar todos estos aspectos para la recuperación del sitio y su entorno ecológico. Con la participación de los más amplios y diversos sectores públicos y privados interesados de los tres niveles de gobierno –federal, estatal y municipal–, se plantea el diseño de un Plan de manejo local y regional que permita el desarrollo sustentable de la zona y de su entorno para que sea abierta al público en general. Lo anterior será una fuente de información y conocimiento histórico, cultural, identitario y ecoturístico, que coadyuvará en el desarrollo integral de las comunidades actuales vecinas y cercanas.

  10. Plan de manejo integral del sitio arqueológico Santa Elena, Tabasco, México

    Directory of Open Access Journals (Sweden)

    Ernesto González Licón

    2013-12-01

    Full Text Available En este artículo se destaca la importancia histórica, cultural y turística del sitio arqueológico de Santa Elena, en el Estado de Tabasco, México. Mediante la ejecución de un proyecto de investigación arqueológica y Plan de Manejo Integral se pretende desarrollar todos estos aspectos para la recuperación del sitio y su entorno ecológico. Con la participación de los más amplios y diversos sectores públicos y privados interesados de los tres niveles de gobierno –federal, estatal y municipal–, se plantea el diseño de un Plan de manejo local y regional que permita el desarrollo sustentable de la zona y de su entorno para que sea abierta al público en general. Lo anterior será una fuente de información y conocimiento histórico, cultural, identitario y ecoturístico, que coadyuvará en el desarrollo integral de las comunidades actuales vecinas y cercanas.

  11. [Implementation of a French cohort of children or adolescents with autism spectrum disorders: ELENA cohort].

    Science.gov (United States)

    Baghdadli, A; Loubersac, J; Soussana, M; Rattaz, C; Michelon, C

    2014-10-01

    Multidisciplinary cohort studies of children with autism spectrum disorders (ASD) followed from childhood to adulthood exist abroad but not in France. The objective of the ELENA French cohort is to study the developmental trajectories of children and adolescents with ASD and their risk or protective associated factors. This is an open, prospective and multicenter cohort study, including children and adolescents under 16 years of age with ASD recruited from services specialized in the assessment of developmental disorders. The patients will be monitored every 18 months for at least 36 months and during a maximum of 10 years. Clinical, social, environmental, and genetic data, as well as data relating to the parental quality of life will be collected. The primary endpoint will be the adaptive level in three domains of the Vineland II (communication, socialization and daily living skills). The secondary endpoints will be parental quality of life, comorbidities, interventions and severity of ASD. The inclusion of 1600 patients over a 10-year period is expected. This cohort should contribute to a better knowledge of the child developing an ASD, taking into account the physical, social and familial environment, the type of interventions and some genetic components. It should also lay the foundations for a national network of professionals working in the field of autism research by offering them a common tool for promoting translational studies. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  12. ELENA GARRO, A DESHORA: FIGURAS LITERARIAS DE LA ABYECCIÓN

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    Meritxell Hernando Marsal

    2014-12-01

    Full Text Available The massacre of Tlatelolco in 1968 was the most bloody incident of Diaz Ordaz’s government in Mexico and promoted a severe process of persecution and repression of the student movement. One of its consequences was the suspicion of betrayal by Elena Garro of the movement’s intellectual authors. Since then, Garro embodied an abject character of collaboration, in constant harassment, leading to her exile during twenty years.This paper considers the implications of the accusation and the diagnosis of insanity that accompanies it. For some critics this insanity is redeemed in her literary work, which in this operation achieves prominence; but the insanity can be thought of as irreducible. Garro’s delirious gaze doesn’t sublimate the trauma, but repeats again and again the political violence, with harassed, exposed and out of place characters, in situations of daily totalitarianism. Figures of betrayal emerge in her histories, involving characters and knowledge outside the language of the official left (animal, children, women, the indigenous, marked by their helplessness and questioning the premises of political parties. 

  13. Research on Synthetic Aperture Radar Processing for the Spaceborne Sliding Spotlight Mode

    Directory of Open Access Journals (Sweden)

    Shijian Shen

    2018-02-01

    Full Text Available Gaofen-3 (GF-3 is China’ first C-band multi-polarization synthetic aperture radar (SAR satellite, which also provides the sliding spotlight mode for the first time. Sliding-spotlight mode is a novel mode to realize imaging with not only high resolution, but also wide swath. Several key technologies for sliding spotlight mode in spaceborne SAR with high resolution are investigated in this paper, mainly including the imaging parameters, the methods of velocity estimation and ambiguity elimination, and the imaging algorithms. Based on the chosen Convolution BackProjection (CBP and PFA (Polar Format Algorithm imaging algorithms, a fast implementation method of CBP and a modified PFA method suitable for sliding spotlight mode are proposed, and the processing flows are derived in detail. Finally, the algorithms are validated by simulations and measured data.

  14. Research on Synthetic Aperture Radar Processing for the Spaceborne Sliding Spotlight Mode.

    Science.gov (United States)

    Shen, Shijian; Nie, Xin; Zhang, Xinggan

    2018-02-03

    Gaofen-3 (GF-3) is China' first C-band multi-polarization synthetic aperture radar (SAR) satellite, which also provides the sliding spotlight mode for the first time. Sliding-spotlight mode is a novel mode to realize imaging with not only high resolution, but also wide swath. Several key technologies for sliding spotlight mode in spaceborne SAR with high resolution are investigated in this paper, mainly including the imaging parameters, the methods of velocity estimation and ambiguity elimination, and the imaging algorithms. Based on the chosen Convolution BackProjection (CBP) and PFA (Polar Format Algorithm) imaging algorithms, a fast implementation method of CBP and a modified PFA method suitable for sliding spotlight mode are proposed, and the processing flows are derived in detail. Finally, the algorithms are validated by simulations and measured data.

  15. Convolution backprojection image reconstruction for spotlight mode synthetic aperture radar.

    Science.gov (United States)

    Desai, M D; Jenkins, W K

    1992-01-01

    Convolution backprojection (CBP) image reconstruction has been proposed as a means of producing high-resolution synthetic-aperture radar (SAR) images by processing data directly in the polar recording format which is the conventional recording format for spotlight mode SAR. The CBP algorithm filters each projection as it is recorded and then backprojects the ensemble of filtered projections to create the final image in a pixel-by-pixel format. CBP reconstruction produces high-quality images by handling the recorded data directly in polar format. The CBP algorithm requires only 1-D interpolation along the filtered projections to determine the precise values that must be contributed to the backprojection summation from each projection. The algorithm is thus able to produce higher quality images by eliminating the inaccuracies of 2-D interpolation, as well as using all the data recorded in the spectral domain annular sector more effectively. The computational complexity of the CBP algorithm is O(N (3)).

  16. Identificación y Caracterización de Cepas Nativas de Rhizobium en la Provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Javier Soto

    2015-10-01

    Full Text Available En los sistemas agrícolas de subsistencia, el nitrógeno es un macronutriente esencial para el buen desarrollo de las plantas; es utilizado en forma de nitrato o amonio. Las bacterias del género Rhizobium poseen la capacidad de fijar el nitrógeno, mediante una relación de simbiosis con leguminosas e influyen en la producción de sustancias promotoras de crecimiento en las plantas no leguminosas. En la península de Santa Elena no existen evidencias del uso y aplicación de biofertilizantes de origen microbiano nativo, por lo que el presente trabajo tuvo como objetivo caracterizar y seleccionar cepas del género Rhizobium procedentes de los nódulos de leguminosas de dos zonas de la provincia de Santa Elena. Los experimentos Aislamiento, identificación y caracterización bioquímica de cepas de Rhizobium encontradas en diferentes zonas de la península de Santa Elena comprende: a Estudio de la morfología nodular de leguminosas; b Presencia de la enzima Leghemoglobina en los nódulos, c Aislamiento de microorganismos de los nódulos de leguminosas, d Respuesta de la enzima catalasa ante el peróxido de hidrógeno, e Crecimiento en diferentes fuentes de carbono , f Crecimiento en tres porcentajes cloruro de sodio; y e Producción de 3-ketolactasa en agar LLA para descartar contaminantes frecuentes como Agrobacterium.

  17. Análisis Estructural de Fallas Geológicas y Potenciales Deslizamientos en Anconcito, Provincia de Santa Elena

    OpenAIRE

    Kervin Chunga

    2015-01-01

    El sector costero de Anconcito, localizado al suroeste de la provincia de Santa Elena, es afectado por fenómenos geológicosinducidos por la dinámica costera de la zona de estudio: (1) socavamiento de los acantilados causado por la dinámica de la erosión marina y posterior derrumbe de estratos rocosos, y (2) deslizamientos de estratos rocosos a través de planos lístricosde fallas geológicas de tipo normal con componentes de desplazamientos laterales dextrales. El análisis estructural permitió ...

  18. Medicina preventiva en la Educación Superior de la Universidad Península de Santa Elena, año 2012

    OpenAIRE

    Cochea Perlaza, Wilson Nicolás

    2012-01-01

    PDF La Organización Panamericana de la Salud y la OMS dentro de sus recomendaciones está el fortalecimiento del talento humano, para la prevención de las enfermedades y el fomento y Proción de la Salud.En la Provincia de Santa Elena, funciona desde hace trece años la Universidad Península de Santa Elena, donde se forman cerca de siete mil estudiantes en veintiséis carreras; existiendo la Facultad de Ciencias Sociales y de la Salud conformada por las carreras de Enfermería...

  19. Dilemma in new clean and renewable energy alternatives for Santa Elena and its university. Opportunities and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Moreano, Hernan [Universidad Estatal Peninsula de Santa Elena (Ecuador). Inst. de Investigacion Cientifica y Desarrollo Tecnologico (INCYT)

    2011-07-01

    The fate of finite fossil fuel sources for the coming decades and the need to migrate to renewable energy in a joint effort among governments, academia and private companies which make business in the energy arena are discussed and also the energy balance in Ecuador which shows a strong dependence of fossil fuels to satisfy demand from both: thermoelectric plants and transport, however, Santa Elena, the newly created province at the south western of Ecuador has the chance to turn the country energy situation into an opportunity and face the challenge to be the leader in energy alternatives because of its resources and chances to migrate sooner to environmental friendly fuels and later on to renewable energies, but a number of actions should be taken in a joint effort with its local university (UPSE), government bodies and private companies in order to create the ''Campus of Energy Knowledge'' to carry out the program: Energy Alternatives for Santa Elena, which includes 7 projects to make the province a leader one on the energy issue in Ecuador and in the continent, acting on a cluster initiative scheme. (orig.)

  20. The Regina Elena National Cancer Institute process of accreditation according to the standards of the Organisation of European Cancer Institutes.

    Science.gov (United States)

    Canitano, Stefano; Di Turi, Annunziata; Caolo, Giuseppina; Pignatelli, Adriana C; Papa, Elena; Branca, Marta; Cerimele, Marina; De Maria, Ruggero

    2015-01-01

    The accreditation process is, on the one hand, a tool used to homogenize procedures, rendering comparable and standardized processes of care, and on the other, a methodology employed to develop a culture of quality improvement. Although not yet proven by evidence-based studies that health outcomes improve as a result of an accreditation to excellence, it is undeniable that better control of healthcare processes results in better quality and safety of diagnostic and therapeutic pathways. The Regina Elena National Cancer Institute underwent the accreditation process in accordance with the standards criteria set by the Organisation of European Cancer Institutes (OECI), and it has recently completed the process, acquiring its designation as a Comprehensive Cancer Center (CCC). This was an invaluable opportunity for the Regina Elena Institute to create a more cohesive environment, to widely establish a culture of quality, to implement an institutional information system, and to accelerate the process of patient involvement in strategic decisions. The steps of the process allowed us to evaluate the performance and the organization of the institute and put amendments in place designed to be adopted through 26 improvement actions. These actions regarded several aspects of the institute, including quality culture, information communication technology system, care, clinical trials unit, disease management team, nursing, and patient empowerment and involvement. Each area has a timeline. We chose to present the following 3 improvement actions: clinical trial center, computerized ambulatory medical record, and centrality of patient and humanization of clinical pathway.

  1. Methane Dynamics in a Tropical Serpentinizing Environment: The Santa Elena Ophiolite, Costa Rica

    Directory of Open Access Journals (Sweden)

    Melitza Crespo-Medina

    2017-05-01

    Full Text Available Uplifted ultramafic rocks represent an important vector for the transfer of carbon and reducing power from the deep subsurface into the biosphere and potentially support microbial life through serpentinization. This process has a strong influence upon the production of hydrogen and methane, which can be subsequently consumed by microbial communities. The Santa Elena Ophiolite (SEO on the northwestern Pacific coast of Costa Rica comprises ~250 km2 of ultramafic rocks and mafic associations. The climatic conditions, consisting of strongly contrasting wet and dry seasons, make the SEO a unique hydrogeological setting, where water-rock reactions are enhanced by large storm events (up to 200 mm in a single storm. Previous work on hyperalkaline spring fluids collected within the SEO has identified the presence of microorganisms potentially involved in hydrogen, methane, and methanol oxidation (such as Hydrogenophaga, Methylobacterium, and Methylibium spp., respectively, as well as the presence of methanogenic Archaea (such as Methanobacterium. Similar organisms have also been documented at other serpentinizing sites, however their functions have not been confirmed. SEO's hyperalkaline springs have elevated methane concentrations, ranging from 145 to 900 μM, in comparison to the background concentrations (<0.3 μM. The presence and potential activity of microorganisms involved in methane cycling in serpentinization-influenced fluids from different sites within the SEO were investigated using molecular, geochemical, and modeling approaches. These results were combined to elucidate the bioenergetically favorable methane production and/or oxidation reactions in this tropical serpentinizing environment. The hyperalkaline springs at SEO contain a greater proportion of Archaea and methanogens than has been detected in any terrestrial serpentinizing system. Archaea involved in methanogenesis and anaerobic methane oxidation accounted from 40 to 90% of total

  2. Methane Dynamics in a Tropical Serpentinizing Environment: The Santa Elena Ophiolite, Costa Rica.

    Science.gov (United States)

    Crespo-Medina, Melitza; Twing, Katrina I; Sánchez-Murillo, Ricardo; Brazelton, William J; McCollom, Thomas M; Schrenk, Matthew O

    2017-01-01

    Uplifted ultramafic rocks represent an important vector for the transfer of carbon and reducing power from the deep subsurface into the biosphere and potentially support microbial life through serpentinization. This process has a strong influence upon the production of hydrogen and methane, which can be subsequently consumed by microbial communities. The Santa Elena Ophiolite (SEO) on the northwestern Pacific coast of Costa Rica comprises ~250 km 2 of ultramafic rocks and mafic associations. The climatic conditions, consisting of strongly contrasting wet and dry seasons, make the SEO a unique hydrogeological setting, where water-rock reactions are enhanced by large storm events (up to 200 mm in a single storm). Previous work on hyperalkaline spring fluids collected within the SEO has identified the presence of microorganisms potentially involved in hydrogen, methane, and methanol oxidation (such as Hydrogenophaga, Methylobacterium , and Methylibium spp., respectively), as well as the presence of methanogenic Archaea (such as Methanobacterium ). Similar organisms have also been documented at other serpentinizing sites, however their functions have not been confirmed. SEO's hyperalkaline springs have elevated methane concentrations, ranging from 145 to 900 μM, in comparison to the background concentrations (<0.3 μM). The presence and potential activity of microorganisms involved in methane cycling in serpentinization-influenced fluids from different sites within the SEO were investigated using molecular, geochemical, and modeling approaches. These results were combined to elucidate the bioenergetically favorable methane production and/or oxidation reactions in this tropical serpentinizing environment. The hyperalkaline springs at SEO contain a greater proportion of Archaea and methanogens than has been detected in any terrestrial serpentinizing system. Archaea involved in methanogenesis and anaerobic methane oxidation accounted from 40 to 90% of total archaeal

  3. EVALUACIÓN PSICOSOCIAL DEL ADULTO MAYOR EN LA PROVINCIA DE SANTA ELENA. 2013

    Directory of Open Access Journals (Sweden)

    Jenny Sornoza

    2016-04-01

    Full Text Available Los adultos mayores constituyen un grupo poblacional significativo, que por tiempos ha estado desatendido, a pesar de que en el año 1990 se dicta la Ley del Anciano aún las personas mencionadas no gozan de todos los beneficios que contiene dicha ley ya que hasta la actualidad dicha ley no se aplica en su totalidad por falta de socialización, desconocimiento de sus beneficios e implementación de los espacios adecuados entre otras limitantes. El objetivo de la investigación fue el de Realizar una evaluación psicológica y social a los adultos mayores de la provincia en mención, tomando como muestras a las diferentes agrupaciones existentes en varias comunidades y cantones, para crear un modelo de evaluación integral para la optimización de la atención primaria de la salud geriátrica en la Provincia de Santa Elena, al igual que se pretende diseñar propuestas de trabajo que mejoren su condición de vida, puesto que es un sector generalmente abandonado y vulnerable con fácil tendencia a la depresión ; en este estudio participan docentes y estudiantes de la carrera de psicología, y el apoyo coordinado del Ministerio de Inclusión Económica y Social con sus organizaciones y agrupaciones quienes se constituyeron en población y muestra; se aplicó métodos cuantitativo y cualitativo para la evaluación el aspecto psicológico, funciones mentales, entorno familiar y social con la aplicación de los siguientes instrumentos: Mini Mental, Test de Funcionamiento Familiar, ficha social, test de autoestima, ansiedad y depresión, los mismos que nos permitieron comprender cada una de las áreas mencionadas para tener una mirada del contexto general de la población investigada. Entre los hallazgos más relevantes tenemos síntomas de depresión, sentimientos de inutilidad y expectativas de encontrar espacios en los que puedan sentirse productivos y a la vez ocupar su tiempo; así mismo soledad, percepción de abandono familiar entre otros.

  4. EL MANEJO COSTERO INTEGRADO COMO PROBLEMA DE INVESTIGACIÓN TRANSDISCIPLINARIO EN LA UNIVERSIDAD PENÍNSULA DE SANTA ELENA.

    Directory of Open Access Journals (Sweden)

    Vladimir Soria

    2016-04-01

    Full Text Available La investigación generativa es uno de los dominios sobre los cuales las universidades deben mostrar fortalezas para justificar su pertinencia y permanencia en el sistema ecuatoriano de educación superior. En enfoque transdisciplinario o de orquestación de ciencias se ha mostrado como el más apreciado dentro de la actual modelo de universidad, y una propuesta válida para responder a dicha exigencia es el estudio del manejo costero integrado como eje transversal dentro de la Universidad Estatal Península de Santa Elena. A través de la literatura científica se ha estudiado el manejo costero integrado como una forma de gobernanza ambiental cuyo origen se encuentra en los documentos generados en la Cumbre de la Tierra de Río de Janeiro en el año 1992. Dentro de la provincia de Santa Elena el Manejo Costero Integrado busca incidir en dos aspectos: fortalecimiento institucional y participación ciudadana. El deficiente control ambiental en la faja costera existente exige un modelo de gestión a escala local basado en tres ejes: el fortalecimiento de las capacidades institucionales de las instituciones públicas desconcentradas; el ordenamiento territorial para una adecuada determinación y delimitación de las competencias en materia ambiental costera; y la participación ciudadana a nivel del régimen de las comunas en coordinación con los distintos niveles de gobierno. Se propone articular la investigación en la materia tanto a nivel interdisciplinario como interinstitucional, coordinando agendas de investigación de las instituciones públicas y privadas con las estrategias de los distintos actores políticos involucrados en el desarrollo sustentable de las zonas costeras. Finalmente se presentan los resultados preliminares de una investigación que se ha iniciado en la Facultad de Ciencias Administrativas sobre las características específicas de cada comuna ubicada en la faja costera para posteriormente proponer para cada una de ellas

  5. Benito Fernández de Elena Garro: una mirada crítica sobre la historia mexicana

    Directory of Open Access Journals (Sweden)

    Gerardo Bustamante Bermúdez

    2017-07-01

    Full Text Available En 1957, Elena Garro escribió la obra teatral Benito Fernández, texto en el que hace una revisión crítica a la historia nacional, el poder, la simulación y la búsqueda de la identidad personal en medio de la sociedad creada a partir de la posrevolución mexicana. La obra de la escritora es un contradiscurso a la oficialidad, a la mitificación de los hechos y héroes nacionales; lo que le interesa es resaltar el carácter racista y clasista de una nueva sociedad de dirigentes políticos en busca del bienestar personal y de grupo por encima del bien colectivo, para ello, opta porque en su obra los personajes se preocupen por comprar una cabeza, es decir, una ideología que les haga saber que existen. In 1957, Elena Garro wrote the play Benito Fernández, a text in which she critically reviews Mexico's national history, issues of power, simulation and the quest for personal identity in the midst of a society emerged in the after effects of the Mexican Revolution. This work is a counter-discourse to Mexico's official narrative and the idealization of facts and national heroes. She is interested in the racist and classist aspects of the new dominating society, which is interested in their own personal welfare over those of the collective. To do so, she makes her characters concerned about buying a head, that is, an ideology to fundament their own existence.

  6. Geochemical evidence for active tropical serpentinization in the Santa Elena Ophiolite, Costa Rica: An analog of a humid early Earth?

    Science.gov (United States)

    Sánchez-Murillo, Ricardo; Gazel, Esteban; Schwarzenbach, Esther M.; Crespo-Medina, Melitza; Schrenk, Matthew O.; Boll, Jan; Gill, Ben C.

    2014-05-01

    Serpentinization is a planetary process that has important consequences on geochemical cycles, supporting microbial activity through the formation of H2 and CH4 and having the potential to sequester atmospheric CO2. We present geochemical evidence of active serpentinization in the Santa Elena Ophiolite, Costa Rica which is sustained by peridotites with a degree of serpentinization less than 50% with no evidence of an internal heat source. Average spring water temperatures are 29.1°C. Two hyperalkaline spring systems were discovered, with a spring fluid pH up to 11.18. The fluids are characterized by low Mg (1.0-5.9 mg/L) and K (1.0-5.5 mg/L) and relative high Ca (29-167 mg/L), Na (16-27 mg/L), Cl (26-29 mg/L), hydroxide (41-63 mg/L), and carbonate (31-49 mg/L). Active CH4 (24.3% v/v) vents coupled with carbonate deposits (δ13CCO2 =-27 to -14‰; δ18OCO2 =-17 to - 6‰) also provide evidence for active serpentinization and carbonation. Isotope ratios of the alkaline fluids (δ18O = -7.9‰, δ2H = -51.4‰) and groundwater (δ18O = -7.6‰; δ2H = -48.0‰) suggests that, during base flow recession, springs are fed by groundwater circulation. Methanogenic Archaea, which comprises a relatively high percentage of the 16S rRNA gene tag sequences, suggests that biological methanogenesis may play a significant role in the system. Santa Elena's extreme varying weather results in a scenario that could be of significant importance for (a) improving the knowledge of conditions on a humid early Earth or Mars that had periodic changes in water supply, (b) revealing new insights on serpentinizing solute transport, and (c) modeling hydrogeochemical responses as a function of recharge.

  7. Diarrhea & Child Care: Controlling Diarrhea in Out-of-Home Child Care. NCEDL Spotlights, No. 4.

    Science.gov (United States)

    Churchill, Robin B.; Pickering, Larry K.

    This report, the fourth in the National Center for Early Development and Learning's (NCEDL) "Spotlights" series, is based on excerpts from a paper presented during a "Research into Practice in Infant/Toddler Care" synthesis conference in fall 1997. The report addresses controlling diarrhea in out-of-home child care. The report…

  8. It counts who counts: an experimental evaluation of the importance of observer effects on spotlight count estimates

    DEFF Research Database (Denmark)

    Sunde, Peter; Jessen, Lonnie

    2013-01-01

    Spotlight surveys conducted by volunteers is a promising method to assess the abundance of nocturnally active mammals, but estimates are subject to bias if different observer groups differ in their ability to detect animals in the dark. We quantified the variation amongst volunteer spotlight...... observers with respect to their ability to detect and estimate distance to realistic animal silhouettes at different distances. Detection probabilities were higher for observers experienced in spotlighting mammals than for inexperienced observers, higher for observers with a hunting background compared...

  9. Electrostatic protocol treatment lens. The purpose of this device is to transport Antiprotons from the new ELENA storage beam to all AD experiments. The electrostatic device was successfully tested in ASACUSA two weeks ago.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    Electrostatic protocol treatment lens. The purpose of this device is to transport Antiprotons from the new ELENA storage beam to all AD experiments. The electrostatic device was successfully tested in ASACUSA two weeks ago.

  10. The EU environmental-energy policy for urban areas: The Covenant of Mayors, the ELENA program and the role of ESCos

    International Nuclear Information System (INIS)

    Lombardi, Mariarosaria; Pazienza, Pasquale; Rana, Roberto

    2016-01-01

    The Covenant of Mayors (CoM) is an initiative of the European Commission started in 2008 with the aim of involving cities more in the implementation of the 20-20-20 climate-energy package. To this end, a variety of tools to assist the realization of such a policy has been built. The European Local Energy Assistance (ELENA) program of the European Investment Bank (EIB) is one of the most relevant. In this work, we observe some data on the Italian participation in the CoM and ELENA program, while highlighting the role the Energy Service Companies have in these contexts. By referring to the specific experience of the Province of Foggia (an intermediary government body in southern Italy), we also discuss how some recent changes in the Italian legislation, aimed at abolishing the provinces (considered as preferred supporting structure of the CoM), imposed the identification of another supraterritorial entity. This is to substitute the Province of Foggia as coordinator in the dialog between the local territory and the European Union institutions on the climate-energy theme. In this sense, the choice of the Chamber of Commerce represents a novelty. With regard to this, some considerations on the appropriateness of this choice are developed. - Highlights: •The CoM is an EU environmental-energy initiative for local authorities. •The ELENA program supports technical energy efficiency activities within the CoM. •Chambers of Commerce can usefully coordinate ELENA projects submission. •Public bodies are committed to implement energy saving projects on their buildings. •The ESCOs develop and implement energy efficiency projects.

  11. Is There any Relationship Between the Santa Elena Depression and Chicxulub Impact Crater, Northwestern Yucatan Peninsula, Mexico?

    Science.gov (United States)

    Lefticariu, L.

    2005-05-01

    The Terminal Cretaceous Chicxulub Impact Crater had a strong control on the depositional and diagenetic history of the northern Yucatan Platform during most of the Cenozoic Era. The Chicxulub Sedimentary Basin (henceforth Basin), which approximately coincides with the impact crater, is circumscribed by a concentration of karstic sinkholes known as the Ring of Cenotes. Santa Elena Depression (henceforth Depression) is the name proposed for the bowl-shaped buried feature, first contoured by geophysical studies, immediately south of the Basin, in the area where the Ticul 1 and UNAM 5 wells were drilled. Lithologic, petrographic, and biostratigraphic data on PEMEX, UNAM, and ICDP cores show that: 1) Cenozoic deposits are much thicker inside the Basin than inside the Depression, 2) in general, the Cenozoic formations from inside the Depression are the thickest among those outside the Basin, 3) variably dolomitized pelagic or outer-platform wackestone or mudstone occur both inside the Basin and Depression, 4) the age of the deeper-water sedimentary carbonate rocks is Paleocene-Eocene inside the Basin and Paleocene?-Early Eocene inside the Depression, 5) the oldest formations that crop out are of Middle Eocene age at the edge of the Basin and Early-Middle Eocene age inside the Depression, 6) saline lake deposits, that consist chiefly of anhydrite, gypsum, and fine carbonate, and also contain quartz, chert, clay, zeolite, potassium feldspar, pyrite, and fragments of wood, are present in the Cenozoic section of the UNAM 5 core between 282 and 198 m below the present land surface, 7) the dolomite, subaerial exposure features (subaerial crusts, vugs, karst, dedolomite), and vug-filling cement from the Eocene formations are more abundant inside the Depression than inside the Basin. The depositional environments that are proposed for explaining the Cenozoic facies succession within the Santa Elena Depression are: 1) deeper marine water (Paleocene?-Early Eocene), 2) relatively

  12. Raw Data-Based Motion Compensation for High-Resolution Sliding Spotlight Synthetic Aperture Radar.

    Science.gov (United States)

    Li, Ning; Niu, Shilin; Guo, Zhengwei; Liu, Yabo; Chen, Jiaqi

    2018-03-12

    For accurate motion compensation (MOCO) in airborne synthetic aperture radar (SAR) imaging, a high-precision inertial navigation system (INS) is required. However, an INS is not always precise enough or is sometimes not even included in airborne SAR systems. In this paper, a new, raw, data-based range-invariant motion compensation approach, which can effectively extract the displacements in the line-of-sight (LOS) direction, is proposed for high-resolution sliding spotlight SAR mode. In this approach, the sub-aperture radial accelerations of the airborne platform are estimated via a well-developed weighted total least square (WTLS) method considering the time-varying beam direction. The effectiveness of the proposed approach is validated by two airborne sliding spotlight C band SAR raw datasets containing different types of terrain, with a high spatial resolution of about 0.15 m in azimuth.

  13. Generalized Chirp Scaling Combined with Baseband Azimuth Scaling Algorithm for Large Bandwidth Sliding Spotlight SAR Imaging.

    Science.gov (United States)

    Yi, Tianzhu; He, Zhihua; He, Feng; Dong, Zhen; Wu, Mnaqing

    2017-05-29

    This paper presents an efficient and precise imaging algorithm for the large bandwidth sliding spotlight synthetic aperture radar (SAR). The existing sub-aperture processing method based on the baseband azimuth scaling (BAS) algorithm cannot cope with the high order phase coupling along the range and azimuth dimensions. This coupling problem causes defocusing along the range and azimuth dimensions. This paper proposes a generalized chirp scaling (GCS)-BAS processing algorithm, which is based on the GCS algorithm. It successfully mitigates the deep focus along the range dimension of a sub-aperture of the large bandwidth sliding spotlight SAR, as well as high order phase coupling along the range and azimuth dimensions. Additionally, the azimuth focusing can be achieved by this azimuth scaling method. Simulation results demonstrate the ability of the GCS-BAS algorithm to process the large bandwidth sliding spotlight SAR data. It is proven that great improvements of the focus depth and imaging accuracy are obtained via the GCS-BAS algorithm.

  14. Herramientas de Marketing y Gerenciales que se emplean en las diferentes Unidades de Negocios de la provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Roxana Álvarez

    2015-10-01

    The company like cell of the economy has to be studied because it turns in actor of the first order. The good health of the company is the good health of the economic one and vice versa. The company is what his manager is; the person interests then brain of the organization. Inside this context this study is realized in search of the organization and activity of the company of the province of Santa Elena. It has been considered so much of marketing a set of variables as managerial that use these units of production and / or commercialization for the attainment of his aims: positioning and economic growth. There takes a sample that includes the most wide business range: companies of retail and wholesale commercialization, of services, of commercialization, of production and of another type. The information obtains across surveys, which then are tabulated, which allows to obtain the tools that use the business in the province. The companies declare the utilization of tools, but his administrators cannot explain form and the procedures in each of the cases, that is to say, do it of intuitive form, more not because they possess the technical knowledge of the same ones.

  15. A leading-edge hardware family for diagnostics applications and low-level RF in CERN's ELENA ring

    CERN Document Server

    Angoletta, M E; Jaussi, M; Leiononen, P; Levens, T E; Molendijk, J C; Sanchez-Quesada, J; Simonin, J

    2013-01-01

    The CERN Extra Low ENergy Antiproton (ELENA) Ring is a new synchrotron that will be commissioned in 2016 to further decelerate the antiprotons transferred from the CERN’s Antiproton Decelerator (AD). The requirements for the acquisition and treatment of signals for longitudinal diagnostics are very demanding, owing to the revolution frequency swing as well as to the digital signal processing required. The requirements for the Low-Level Radio-Frequency (LLRF) system are very demanding as well, especially in terms of revolution frequency swing, dynamic range and low noise required by the cavity voltage control and digital signal processing to be performed. Both sets of requirements will be satisfied by using a leading-edge hardware family, developed to cover the LLRF needs of all synchrotrons in the Meyrin site; it will be first deployed in 2014 in the CERN’s PSB and in the medical machine MedAustron. This paper gives an overview of the main building blocks of the hardware family and of th...

  16. The hELENa project - II. Abundance distribution trends of early-type galaxies: from dwarfs to giants

    Science.gov (United States)

    Sybilska, A.; Kuntschner, H.; van de Ven, G.; Vazdekis, A.; Falcón-Barroso, J.; Peletier, R. F.; Lisker, T.

    2018-02-01

    In this second paper of The role of Environment in shaping Low-mass Early-type Nearby galaxies (hELENa) series we study [Mg/Fe] abundance distribution trends of early-type galaxies observed with the SAURON integral field unit, spanning a wide range in mass and local environment densities: 20 low-mass early-types (dEs) of Sybilska et al. (2017) and 258 massive early types (ETGs) of the ATLAS3D project, all homogeneously reduced and analyzed. We show that the [Mg/Fe] ratios scale with velocity dispersion (σ) at fixed [Fe/H] and that they evolve with [Fe/H] along similar paths for all early-types, grouped in bins of increasing local and global σ, as well as the second velocity moment Vrms, indicating a common inside-out formation pattern. We then place our dEs on the [Mg/Fe] vs. [Fe/H] diagram of Local Group galaxies and show that dEs occupy the same region and show a similar trend line slope in the diagram as the high-metallicity stars of the Milky Way and the Large Magellanic Cloud. This finding extends the similar trend found for dwarf spheroidal vs. dwarf irregular galaxies and supports the notion that dEs have evolved from late-type galaxies that have lost their gas at a point of their evolution, which likely coincided with them entering denser environments.

  17. El estilo de apego en la violencia contra la mujer, en la provincia de Santa Elena, Ecuador.

    Directory of Open Access Journals (Sweden)

    Holguer Romero

    2015-10-01

    The objective is to determine the style of attachment S. What influences the permission of Violence against Women, evaluating the type of violence, which is prevalent in the Province of Santa Elena, in women assaulted by their romantic partners. Analysis Unit is violated That woman accepts Be Part of the Study By signing the Informed Consent. The UN is Metodo JOINT Focus: Comparative correlational, with a quasi-experimental design ex post facto, on the basis of Mixed Media: research based on observation. Information Sera primary and secondary source, the focus is Quantitative and qualitative interview technique employing one profundity and filling the questionnaires. Risk scale Apostolic Violence, CaMir Questionnaire. The personological Features Each with Data Analysis Report of the expert analyzes, para establish A triangulation With The Other Instruments results. With the evaluation of the type of violence, verifying attachment style, Determined The reasons for this addiction abused woman, With obtaining affective-cognitive characteristics; facilitate the evaluation is diagnosed expert, benefiting Rescue of Victims of Violence.

  18. La inserción de los juegos ancestrales practicados por los moradores de la Provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Ana Gallegos Samaniego

    2016-06-01

    Es de suprema importancia la recuperación de todos estos juegos ancestrales, tomados de la naturaleza de la atracción a lo desconocido, de la admiración a lo incomprendido y del coexistir cotidiano con el medio, para acoplarlos en el currículo de educación infantil para los niños de la generación actual, que se encuentran invadidos con la tecnología y que lejos de apreciar sus beneficios, adquieren una absoluta dependencia para realizar estas actividades recreativas. En este contexto se realizaron encuestas a los adultos mayores de las comunas de la zona norte de la provincia de Santa Elena, y se logró determinar que los juegos ancestrales se están dejando de practicar y están quedando en el olvido. La presente investigación no ha sido referenciada por lo que toma relevancia su estudio.

  19. Comportamiento del cultivo del limón (citrus aurantifolia swingle en dos localidades de Santa Elena, Ecuador

    Directory of Open Access Journals (Sweden)

    Mercedes Santistevan

    2016-11-01

    Full Text Available Se realizó una investigación entre agosto y diciembre del 2015, con el objetivo de conocer el comportamiento del cultivo de limón (Citrus aurantifolia Swingle en dos localidades de la Provincia de Santa Elena, Ecuador. Se seleccionaron dos plantaciones de ocho años de edad, en Manglaralto y Colonche. En cada localidad se marcaron 50 plantas, en las que se hicieron las evaluaciones. El ensayo no tuvo un diseño experimental, pero el análisis estadístico se hizo como si fuera un Diseño Completamente al Azar (DCA, considerando cada localidad como un tratamiento y cada planta como una repetición. Se encontró que la mayor incidencia de plagas y enfermedades se presentó en Manglaralto. El mayor diámetro del fruto, correspondió a Colonche, con una diferencia estadísticamente significativa con respecto a Manglaralto. El mayor peso del fruto y el mayor rendimiento, correspondió a Colonche; pero las diferencias no fueron estadísticamente significativas con respecto a Manglaralto

  20. Adaptación del Trigo (Triticum, en diferentes épocas de cuatro localidades, Provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Néstor Orrala B

    2015-10-01

    Full Text Available EL Ecuador importa el 98 % de los requerimientos internos de trigo. Tradicionalmente se cultiva en la Sierra, cuya clima tiene características parecidas a la provincia de Santa Elena en determinada época, lo que podría ser soporte para adaptar este cultivar a las condiciones agroecológicas de la península. La investigación tuvo objetivo verificar el comportamiento agronómico de variedades de trigo en San Vicente de Colonche, Sinchal, Zapotal, San Vicente de Loja con los materiales Cojitambo, Zhalao, Trigo Blanco, Seri-Atila y Tinamou x Lira x Veree, sembradas en diferentes épocas bajo el diseño Bloques Completamente al Azar. Variables experimentales estudiadas: encañado, espigado, altura de la planta, número de macollos; longitud de espiga sin aristas; cantidad de granos llenos y vanos; peso de 1 000 semillas, expresado en gramos; rendimiento por hectárea en kilogramos mas análisis económico. Las etapas fenológicas son más cortas en la Costa con relación a la Sierra; sobresale la localidad San Vicente de Colonche, la primera época y la variedad Zhalao. Algunas variables agronómicas se acercan a los descriptores del INIAP.

  1. DETERMINACION DE FACTORES DE RIESGO DE MOBBING EN LAS EMPRESAS ESTATALES DE LA PROVINCIA DE SANTA ELENA

    Directory of Open Access Journals (Sweden)

    Bertha Maggi De Monserrate

    2016-04-01

    Full Text Available El Mobbing es una patalogía considerada por la Organizacion Mundial de la Salud y la Organizacion Panamericana como una entidad clinica muy violenta que en los ultimos dias ha tomado un auge considerable afectando el desarrollo de las naciones y constituyendo una amenaza para la salud publica a nivel mundial. Este término proviene del vocablo anglosajón que se traduce como acoso moral, psicoterror laboral, violencia psicológica, en resumen una medida de conducta agresiva hacia el trabajador victima, por parte de otro trabajador agresor. Los especialistas coinciden en que se trata de un problema de salud publica, alcanzando el grado de epidemia - pandemia. El objetivo de proyecto es determinar los factores de riesgo que inducen al Mobbing en los trabajadores de los Establecimientos Estatales de la Provincia de Santa Elena, en una muestra al azar de 400 trabajadores. El instrumento de Recoleccion de datos será el Inventario de Acoso Moral de Leyman. El resultado será diagnostico de Mobbing en los trabajadorobjeto de estudio para la intervención psicológica respectiva.

  2. Efecto de NPK en la Producción de Citrus Aurantifolia Swingle V. Sutil en Sinchal, Santa Elena.

    Directory of Open Access Journals (Sweden)

    Néstor Orrala B

    2015-10-01

    Full Text Available La presente investigación evaluó variables agronómicas y de calidad postcosecha en el limón sutil bajo el efecto de diferentes dosis de nitrógeno fosforo y potasio, solas o en combinación aplicados al suelo durante un año calendario, dividida en tres dosis en la comuna Sinchal, cantón Santa Elena. Se utilizó un diseño de completamente aleatorio. Las variables evaluadas fueron de producción: diámetro del fruto, peso del fruto, grosor de la cáscara, rendimiento por árbol y de calidad pos-cosecha: sólidos solubles totales (Grados Brix, porcentaje de acidez títulable, índice de madurez, porcentaje de jugo y análisis económico. Las variables agronómicas y de calidad postcosecha giran alrededor de lo obtenido por investigadores de América Latina y del Ecuador. Tukey 5 % señala diferencias significativas en el rendimiento por planta durante el año analizado. El tratamiento testigo alcanzó 39,43 kg/planta a diferencia del tratamiento 12, que obtuvo 98,11 kg/planta. El análisis económico estableció que los tratamientos N750P150K0, N750P0K0, N1000P150K0, N1250P150K0, N1250P0K0, N750P150K300, superaron la tasa de retorno mínima aceptable, establecida en 100 %; inclusive el tratamiento 8, al tener menor costo que varía con relación al testigo, puede servir a los pequeños productores

  3. The hELENa project - I. Stellar populations of early-type galaxies linked with local environment and galaxy mass

    Science.gov (United States)

    Sybilska, A.; Lisker, T.; Kuntschner, H.; Vazdekis, A.; van de Ven, G.; Peletier, R.; Falcón-Barroso, J.; Vijayaraghavan, R.; Janz, J.

    2017-09-01

    We present the first in a series of papers in The role of Environment in shaping Low-mass Early-type Nearby galaxies (hELENa) project. In this paper, we combine our sample of 20 low-mass early types (dEs) with 258 massive early types (ETGs) from the ATLAS3D survey - all observed with the SAURON integral field unit - to investigate early-type galaxies' stellar population scaling relations and the dependence of the population properties on local environment, extended to the low-σ regime of dEs. The ages in our sample show more scatter at lower σ values, indicative of less massive galaxies being affected by the environment to a higher degree. The shape of the age-σ relations for cluster versus non-cluster galaxies suggests that cluster environment speeds up the placing of galaxies on the red sequence. While the scaling relations are tighter for cluster than for the field/group objects, we find no evidence for a difference in average population characteristics of the two samples. We investigate the properties of our sample in the Virgo cluster as a function of number density (rather than simple clustrocentric distance) and find that dE ages correlate with the local density such that galaxies in regions of lower density are younger, likely because they are later arrivals to the cluster or have experienced less pre-processing in groups, and consequently used up their gas reservoir more recently. Overall, dE properties correlate more strongly with density than those of massive ETGs, which was expected as less massive galaxies are more susceptible to external influences.

  4. Characterizing the nature of melt-rock reaction in peridotites from the Santa Elena Ophiolite, NW Costa Rica

    Science.gov (United States)

    Carr, D.; Loocke, M. P.; Snow, J. E.; Gazel, E.

    2017-12-01

    The Santa Elena Ophiolite (SEO), located on the northwestern coast of Costa Rica, consists primarily of preserved oceanic mantle and crustal rocks thrust above an accretionary complex. The SEO is predominantly characterized by mantle peridotites (i.e., primarily spinel lherzolite with minor amounts of harzburgite and dunite) cut and intruded by minor pegmatitic gabbros, layered gabbros, plagiogranites, and doleritic and basaltic dykes. Previous studies have concluded that the complex formed in a suprasubduction zone (SSZ) setting based on the geochemical nature of the layered gabbros and plagiogranites (i.e., depleted LREE and HFSE and enriched LILE and Pb), as well, as the peridotites (i.e., low-TiO2, Zr, and V, and high MgO, Cr, and Ni)(Denyer and Gazel, 2009). Eighteen ultramafic samples collected during the winter 2010/2011 field season (SECR11) exhibit abundant evidence for melt-rock reaction (e.g., disseminated plagioclase and plagioclase-spinel, clinopyroxene-spinel, and plagioclase-clinopyroxene symplectites) and provide a unique opportunity to characterize the textural and chemical nature of melt-rock reaction in the SEO. We present the results of a petrologic investigation (i.e., petrography and electron probe microanalysis) of 28 thin sections (19 spinel lherzolites, of which 14 are plagioclase-bearing, 4 pyroxenite veins, and 5 harzburgites) derived from the SECR11 sample set. The results of this investigation have the potential to better our understanding of the nature of melt generation and migration and melt-rock interaction in the SEO mantle section and shed further light on the complex petrogenetic history of the SEO. Denyer, P., Gazel, E., 2009, Journal of South American Earth Sciences, 28:429-442.

  5. Los juegos tradicionales se han perdido en la memoria cultural actual de los niños y niñas de la provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Patricia Ortega Ramírez

    2016-06-01

    Full Text Available El presente trabajo de investigación se inicio en la Península de Santa Elena, pues es ahí donde nació nuestra cultura ancestral. Nuestro propósito fue confirmar la hipótesis de si los niños y niñas aún participan en actividades lúdicas ancestrales. Se seleccionaron quince comunas de la Provincia de Santa Elena (La Entrada, Olón, Montañita, Dos Mangas, Sacachún, Cadeate, Salinas, Ancón, Atahualpa, Valdivia, Libertador Bolívar, El Tambo, San Vicente, Ayangue y Santa Elena a fin de realizar el estudio, se aplicaron encuestas, se realizaron entrevistas, se escucharon referencias de vida, y se observaron actividades de juego. Los resultados de las encuestas nos dicen que efectivamente un gran porcentaje de niños y niñas ya no conocen ni practican juegos ancestrales, algunos ni siquiera los conocen. Este trabajo pretende que los niños y niñas de las comunas en las que se realizó la investigación disfruten participando en los juegos con los que también se divirtieron sus antepasados, donde además ejercitaran sus habilidades y destrezas, que les permitirá estimular su imaginación y creatividad, fisicamente potenciaran el desarrollo de su esquema corporal y psíquicamente sus emociones, aprenderán a través del juego a sentirse orgullosos de su linaje, de sus raíces y de su tradición.

  6. DISPONIBILIDAD DE RAÍCES ADVENTICIAS DE TRES ESPECIES SILVESTRES COSECHADAS PARA LA ELABORACIÓN DE ARTESANÍAS EN SANTA ELENA, ANTIOQUIA (COLOMBIA

    Directory of Open Access Journals (Sweden)

    ANA MARÍA BENAVIDES

    2015-01-01

    Full Text Available En los Andes colombianos, un gran número de artesanías se fabrican a partir de raíces adventicias de plantas nativas que crecen de forma silvestre. Sin embargo, la deforestación y las prácticas no sustentables han diezmado la disponibilidad de plantas silvestres productoras de fibra. En este estudio evaluamos la disponibilidad de fibras de tres especies en Santa Elena (Antioquia, Colombia: Asplundia sarmentosa, Philodendron aff. sagittifolium y Clusia multiflora. Después de una búsqueda exhaustiva en la zona de estudio ubicamos menos de 30 individuos adultos de cada especie. Para cada planta se midieron las variables asociadas al tamaño de la planta y se registró el número y la longitud de raíces maduras e inmaduras. Se pesaron fragmentos de raíces para estimar la biomasa. El crecimiento de raíces de cada planta fue monitoreado mensualmente durante siete meses. La disponibilidad actual de fibra (raíces maduras es de ca. 3 352 m (Asplundia 1 481 m, Clusia de 952 m, Philodendron 918 m, con esta cantidad de material se pueden elaborar entre 419 a 838 canastos. De acuerdo a la tasa de crecimiento mensual, una nueva raíz podría alcanzar un tamaño para ser cosechado entre el mes 38 y 71. Plantas más grandes tienen mayor cantidad de raíces maduras, sin embargo, la tasa de crecimiento no está asociada al tamaño de la planta. Nuestros resultados proveen evidencia de que las plantas en Santa Elena presentan una relación (tamaño de la planta, número de raíces maduras que es similar a plantas que se encuentran en zonas no intervenidas, no obstante, la cosecha de fibras en Santa Elena no es una actividad sostenible debido al bajo número de individuos susceptibles de ser cosechados, la lenta tasa de crecimiento de raíces y la alta demanda de fibras. Es necesario implementar estrategias como el enriquecimiento del bosque con estas tres especies para garantizar una actividad sustentable para recolectores y artesanos en Santa Elena y

  7. Karim Benmiloud et Alba Lara-Alengrin, Tres escritoras mexicanas. Elena Poniatwoska, Ana García Bergua, Cristina Rivera Garza

    OpenAIRE

    Ponce, Néstor

    2014-01-01

    Las Presses Universitaires de Rennes acaban de publicar un volumen de crítica sobre tres escritoras mexicanas contemporáneas : Elena Poniatwoska, Ana García Bergua y Cristina Rivera Garza. El libro reúne dieciocho estudios de especialistas en la literatura y la cultura de ese país, y se completa con una introducción de los dos coordinadores, con una conclusión (“colofón”) de Alba Lara-Alengrin y con tres textos de presentación de las tres autoras. En estas páginas, las escritoras vuelven sobr...

  8. Propuesta de políticas sociales para erradicar la pobreza de las comunidades de la península de Santa Elena

    OpenAIRE

    Leon, Monica Irene; Martinez, Joan; Zavala Aguiar, Laila; Espinel, Ramon

    2009-01-01

    En el presente estudio se realizó el análisis de la pobreza en la Península de Santa Elena, por ser esta la zona geográfica de mayor concentración en la provincia del Guayas tomando como base la deficiencia en los niveles educativos de los habitantes de la Península y su influencia en la pobreza por medio del ingreso. Utilizando como herramienta el modelo econométrico presentado por Pablo Samaniego al Banco Central del Ecuador. En primer lugar se mencionan los antecedentes y definición del pr...

  9. Incidencia de la inteligencia competitiva en el desarrollo económico de las empresas de la provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Nathyn Collins Ventura

    2017-05-01

    Full Text Available El objetivo de este artículo fue analizar la incidencia de la inteligencia competitiva en el desarrollo económico de las empresas. La inteligencia competitiva ayuda a las empresas a definir y conocer la industria, así como a identificar las fortalezas y debilidades de sus rivales, lo que incluye actividades de inteligencia para reunir datos sobre los competidores e interpretarlo; si se hace correctamente, ayuda a la compañía a evitar sorpresas porque se anticipan los movimientos de los competidores y se disminuye el tiempo de respuesta. Se implementó una investigación exploratoria correlacional para poder diagnosticar el desempeño organizacional de las empresas de la provincia de Santa Elena. Los métodos implementados son deductivo e inductivo, mediante técnicas de observación descriptiva, entrevistas a gerentes de las empresas y encuestas a trabajadores de las empresas para conocer la situación real. Se seleccionó 32 empresas de la provincia de Santa Elena en las que se efectuaron entrevistas a gerentes. Los resultados demuestran que, con la potenciación de fortalezas de la empresa, y por ende el aprovechamiento de oportunidades del entorno, se generará un desarrollo económico de la empresa que implemente acciones sólidas y oportunas.   Abstract The objective of this article was to analyze the incidence of competitive intelligence in the economic development of companies. Competitive intelligence helps companies define and know the industry, as well as identify the strengths and weaknesses of their rivals, which includes intelligence activities to gather data about competitors and interpret it; If done correctly, helps the company to avoid surprises because they anticipate the movements of competitors and decreases the response time. An exploratory correlational research was implemented to diagnose the organizational performance of companies in the province of Santa Elena. The methods implemented are deductive and inductive

  10. An Improved Doppler Rate Estimation Approach for Sliding Spotlight SAR Data Based on the Transposition Domain

    Directory of Open Access Journals (Sweden)

    She Xiao-qiang

    2014-08-01

    Full Text Available In image processing of high-resolution sliding spotlight SAR, it is important to know the Doppler rate with accuracy; however, traditional Doppler rate estimation algorithms are not very helpful because of the azimuth spectrum folding phenomenon. In this study, an algorithm that works on the transposition domain is proposed to solve this problem. Furthermore, the algorithm is also helpful in obtaining excellent focused images by embedding it in the two-step technique. Finally, the proposed algorithm is verified using computer simulations.

  11. An implementation of a fast backprojection image formation algorithm for spotlight-mode SAR

    Science.gov (United States)

    Wahl, Daniel E.; Yocky, David A.; Jakowatz, Charles V., Jr.

    2008-04-01

    In this paper we describe an algorithm for fast spotlight-mode synthetic aperture radar (SAR) image formation that employs backprojection as the core, but is implemented such that its compute time is comparable to the often-used Polar Format Algorithm (PFA). (Standard backprojection is so much slower than PFA that it is impractical to use in many operational scenarios.) We demonstrate the feasibility of the algorithm on real SAR phase history data sets and show some advantages in the SAR image formed by this technique.

  12. Cherry Featured in NCI’s Spotlight on Scientists Video Series | Poster

    Science.gov (United States)

    James Cherry, Ph.D., learned at an early age that education is crucial to success. He credits his mentors, some of whom include his grandmother, Shepherd University professor Burton Lidgerding, Ph.D., David Munroe, Ph.D., Frederick National Lab, and Robert J. Hohman, Ph.D., National Institute of Allergy and Infectious Diseases, for guiding him to the career he has today. Cherry, scientific program director, Office of Scientific Operations (OSO), NCI at Frederick, is one of the scientists featured in NCI’s Spotlight on Scientists video series.

  13. Mejoras productivas en el tratamiento de Paja Toquilla en el Centro de Tratamiento de Paja Toquilla de la comuna Barcelona, parroquia Manglaralto, provincia de Santa Elena, Ecuador.

    Directory of Open Access Journals (Sweden)

    Jorge Lucin

    2015-10-01

    The community of Barcelona, parish ManglaraltoCantón Santa Elena, is known for its treatment of the straw shawl floor (Carludovicapalmata. In its acres of land in the mountains adjacent to the Chongón-Colonche range, this plant grows wild it is harvested in about three years of cultivation. In the village, families headed by women workers, performing the treatment plant for cleaning, cooking, drying and packaging processes, which will be directed to areas in the country where they make the famous Panama hats. In order to improve the process of this treatment, the NOBS group, The Provincial Council of Santa Elena and PORAMÉRICA,   have signed a cooperation agreement that has managed to achieve the objectives. The drying process, which was a problem in times of lack of sun, has been solved with installation of industrial dryers and simultaneously marginalized cooking process and do it with wood stove, achieving efficiency in this process with the use of burners with industrial gas, lowering environmental impact. The administrative process improved with the implementation of documents and control of the production process and costs.

  14. Observatorio turístico: Una herramienta de gestión para el turismo de sol y playa en la provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Efren Mendoza

    2016-12-01

    Tourism in the province of Santa Elena has become a sector of great importance, which has been not only supported by government policies, but also by initiatives of businessmen and communities. Tourism planning has become the best tool for successful and sustainable development of the activity aiming towards the objectives set in the National Plan for Good Living, by following the guidelines established by PLANDETUR (Strategic Development Plan for Sustainable Tourism in Ecuador 2020, while accepting at the same time, the recommendations based on reality where tourism arises. One of the tangible needs is based on the lack of reliable information available about the characteristics of the demand in respect to the Sun and Beach tourism offer; which is the leading product of the province.  This data is significant to support decision-making for each of the actors that make up this vast sector.  This paper shows some results obtained in the investigation through the application of actions taken to design a tourist observatory targeted to the Sun and Beach tourism in Santa Elena, and monitored through the establishment of a base for the guidelines of a management system for tourism information, and by the establishment of the profile of domestic demand.

  15. Book review, Animali da compagnia: tutele – diritti – responsabilità, Elena Bassoli (a cura di

    Directory of Open Access Journals (Sweden)

    Manuel Graziani

    2012-12-01

    Full Text Available L'avvocato, docente universitario e presidente dell'Associazione Nazionale Giuristi Informatici e Forensi, Elena Bassoli, ha curato un manuale che affronta le problematiche relative ai diritti degli animali, approfondendo prima la legislazione internazionale e poi le singole pieghe di quella italiana. Il dato da cui si parte sembra secondario ma, invero, è assai rilevante, ovvero che nel nostro Paese si è passati molto lentamente da una concezione esclusivamente utilitaristica degli animali (tutelati in quanto proprietà di qualcuno all'affermazione dei diritti propri dell'animale in quanto tale.Animali da compagnia: tutele – diritti – responsabilità è utile soprattutto alla luce dei Trattati internazionali (D.U.D.A., Trattato di Amsterdam, Trattato di Lisbona che nel corso degli anni hanno introdotto la tutela dell'animale nelle legislazioni di tutto il mondo. La curatrice e i collaboratori hanno analizzato la recente giurisprudenza sugli animali da compagnia e le varie fonti del diritto nazionale, europeo e internazionale, passando in rassegna le norme di riferimento e indicandone l'applicabilità e le procedure con il fine dichiarato di: "Offrire al lettore uno strumento utile, rigoroso e scritto in modo chiaro e comprensibile anche per chi, per la prima volta, si trovi ad affrontare questa parte del diritto". Il manuale si presenta precipuamente come uno strumento di lavoro per i professionisti che trattano le problematiche relative al mondo degli animali domestici. Va segnalata, in proposito, la chiarezza non solo nell'esposizione dei concetti ma anche nell'architettura editoriale. I 10 capitoli che lo compongono forniscono un inquadramento sistematico delle implicazioni amministrative e penali, con rimandi a diverse note per una maggiore chiarezza del testo: dalle origini del diritto animale (dall'antica Grecia all'animalismo contemporaneo, con in mezzo Medioevo, Rinascimento e Darwinismo passando alla tutela degli animali nell

  16. Putting culture under the 'spotlight' reveals universal information use for face recognition.

    Science.gov (United States)

    Caldara, Roberto; Zhou, Xinyue; Miellet, Sébastien

    2010-03-18

    Eye movement strategies employed by humans to identify conspecifics are not universal. Westerners predominantly fixate the eyes during face recognition, whereas Easterners more the nose region, yet recognition accuracy is comparable. However, natural fixations do not unequivocally represent information extraction. So the question of whether humans universally use identical facial information to recognize faces remains unresolved. We monitored eye movements during face recognition of Western Caucasian (WC) and East Asian (EA) observers with a novel technique in face recognition that parametrically restricts information outside central vision. We used 'Spotlights' with Gaussian apertures of 2 degrees, 5 degrees or 8 degrees dynamically centered on observers' fixations. Strikingly, in constrained Spotlight conditions (2 degrees and 5 degrees) observers of both cultures actively fixated the same facial information: the eyes and mouth. When information from both eyes and mouth was simultaneously available when fixating the nose (8 degrees), as expected EA observers shifted their fixations towards this region. Social experience and cultural factors shape the strategies used to extract information from faces, but these results suggest that external forces do not modulate information use. Human beings rely on identical facial information to recognize conspecifics, a universal law that might be dictated by the evolutionary constraints of nature and not nurture.

  17. Comparison of algorithms for use in real-time spotlight-mode SAR image formation

    Science.gov (United States)

    Jakowatz, Charles V., Jr.; Wahl, Daniel E.; Yocky, David A.; Bray, Brian K.; Bow, Wallace J., Jr.; Richards, John A.

    2004-09-01

    This paper compares three algorithms for potential use in a real-time, on-board implementation of spotlight-mode SAR image formation. These include: the polar formatting algorithm (PFA), the range migration algorithm (RMA), and the overlapped subapertures algorithm (OSA). We conclude that for any reasonable spotlight-mode imaging scenario, PFA is easily the algorithm of choice because its computational efficiency is significantly higher than that of either RMA or OSA. This comparison specifically includes cases in which wavefront curvature is sufficient to cause image defocus in conventional PFA, because a post-processing refocus step can be performed with PFA to yield excellent image quality for only a minimal increase in computation time. We demonstrate that real-time image formation for many imaging scenarios is achievable using PFA implemented on a single Pentium M processor. OSA is quite slow compared to PFA, especially for the case of moderate to high resolution (9 inches and better). RMA is not competitive with PFA for situations that do not require wavefront curvature correction. For those cases in which PFA requires post-processing to correct for wavefront curvature, RMA comes closer in efficiency to PFA, but is still outperformed by the modified PFA.

  18. Hospitality and Inclusion Logistics of a Spotlight Event: An Insiders Look at the 2016 DNC in Philadelphia

    Directory of Open Access Journals (Sweden)

    Leora Halpern Lanz

    2016-10-01

    Full Text Available The 2016 Democratic National Convention held in Philadelphia, Pennsylvania prioritized hospitality efforts and incorporated inclusion and diversity as its theme. These strategies helped to create a successful spotlight event, benefiting the city of Philadelphia and its hospitality industry.

  19. Scientist Spotlight Homework Assignments Shift Students’ Stereotypes of Scientists and Enhance Science Identity in a Diverse Introductory Science Class

    Science.gov (United States)

    Schinske, Jeffrey N.; Perkins, Heather; Snyder, Amanda; Wyer, Mary

    2016-01-01

    Research into science identity, stereotype threat, and possible selves suggests a lack of diverse representations of scientists could impede traditionally underserved students from persisting and succeeding in science. We evaluated a series of metacognitive homework assignments (“Scientist Spotlights”) that featured counterstereotypical examples of scientists in an introductory biology class at a diverse community college. Scientist Spotlights additionally served as tools for content coverage, as scientists were selected to match topics covered each week. We analyzed beginning- and end-of-course essays completed by students during each of five courses with Scientist Spotlights and two courses with equivalent homework assignments that lacked connections to the stories of diverse scientists. Students completing Scientist Spotlights shifted toward counterstereotypical descriptions of scientists and conveyed an enhanced ability to personally relate to scientists following the intervention. Longitudinal data suggested these shifts were maintained 6 months after the completion of the course. Analyses further uncovered correlations between these shifts, interest in science, and course grades. As Scientist Spotlights require very little class time and complement existing curricula, they represent a promising tool for enhancing science identity, shifting stereotypes, and connecting content to issues of equity and diversity in a broad range of STEM classrooms. PMID:27587856

  20. EFECTOS PSICOSOCIALES Y CULTURALES DEL DESPLAZAMIENTO. MARTHA NUBIA BELLO, ELENA MARTÍN CARDINAL Y FERNANDO JIOVANI ARIAS (EDITORES. UNIVERSIDAD NACIONAL DE COLOMBIA, DIVISIÓN DE EXTENSIÓN: PIUPC; SANTAFE DE BOGOTÁ, 2000

    Directory of Open Access Journals (Sweden)

    Leila Lima

    2012-04-01

    Full Text Available A través de los editores, Martha Nubia Bello, Elena Martín Cardinal y Fernando Jiovani Arias, varios autorizados/as autores/as nos entregan interesantes artículos, sobre los efectos psicosociales y culturales del Desplazamiento forzado en Colombia.

  1. José María Díez Borque, dir., Álvaro Bustos Táuler and Elena Di Pinto Revuelta, eds., Hacia el gracioso: Comicidad en el teatro español del siglo XVI

    Directory of Open Access Journals (Sweden)

    Jesús Gómez

    2015-01-01

    Full Text Available Review of José María Díez Borque, dir., Álvaro Bustos Táuler and Elena Di Pinto Revuelta, eds., Hacia el gracioso: Comicidad en el teatro español del siglo XVI, Visor Libros, Madrid, 2014, 236 pp. ISBN: 9788498951547.

  2. Cómo mejorar las competencias de los docentes. Guía para la autoevaluación y el desarrollo de las competencias del profesorado (Autora: Elena Cano García. Barcelona: Editorial Graó, 2005

    Directory of Open Access Journals (Sweden)

    Esperanza Bausela-Herreras

    2007-06-01

    Full Text Available Publicación: Cómo mejorar las competencias de los docentes. Guía para la autoevaluación y el desarrollo de las competencias del profesorado (Autora: Elena Cano García. Barcelona: Editorial Graó, 2005

  3. Scientist Spotlight Homework Assignments Shift Students' Stereotypes of Scientists and Enhance Science Identity in a Diverse Introductory Science Class.

    Science.gov (United States)

    Schinske, Jeffrey N; Perkins, Heather; Snyder, Amanda; Wyer, Mary

    2016-01-01

    Research into science identity, stereotype threat, and possible selves suggests a lack of diverse representations of scientists could impede traditionally underserved students from persisting and succeeding in science. We evaluated a series of metacognitive homework assignments ("Scientist Spotlights") that featured counterstereotypical examples of scientists in an introductory biology class at a diverse community college. Scientist Spotlights additionally served as tools for content coverage, as scientists were selected to match topics covered each week. We analyzed beginning- and end-of-course essays completed by students during each of five courses with Scientist Spotlights and two courses with equivalent homework assignments that lacked connections to the stories of diverse scientists. Students completing Scientist Spotlights shifted toward counterstereotypical descriptions of scientists and conveyed an enhanced ability to personally relate to scientists following the intervention. Longitudinal data suggested these shifts were maintained 6 months after the completion of the course. Analyses further uncovered correlations between these shifts, interest in science, and course grades. As Scientist Spotlights require very little class time and complement existing curricula, they represent a promising tool for enhancing science identity, shifting stereotypes, and connecting content to issues of equity and diversity in a broad range of STEM classrooms. © 2016 J. N. Schinske et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  4. Geolocation with error analysis using imagery from an experimental spotlight SAR

    Science.gov (United States)

    Wonnacott, William Mark

    This dissertation covers the development of a geometry-based sensor model for a specific monostatic spotlight synthetic aperture radar (SAR) system---referred to as the ExSAR (for experimental SAR). This sensor model facilitates single- and multiple-image geopositioning with error analysis. It allows for the use of known ground control points in refining the collection geometry parameters (a process called image resection) and for the subsequent geopositioning of other points using the resected image. Theoretically, the model also allows for the potential recovery of bias-like, persistent errors common across multiple images. The model also includes multi-image correspondence equations to aid in the cross-image identification of conjugate points. The sensor model development begins with a generic, theoretical approach to the modeling of spotlight SAR. A closed-form solution to the range and range-rate condition equations and the corresponding error propagation equation are presented. (The SAR condition equations have traditionally been solved iteratively.) The application of the closed-form solution in the image-to-ground and ground-to-image transformations is documented. The theoretical work also includes a preliminary error sensitivity analysis and a treatment of the spotlight SAR resection process. The ExSAR-specific model is established and assessed with an extensive set of images collected using the experimental radar over arrays of ground control points. Using this set, the imagery metadata elements are assessed, and the optimal element set for geopositioning is determined. The ExSAR imagery is shown to be transformed to the ground plane in only one dimension. The eventual ExSAR sensor model is used with known elevations and single-image geopositioning to show a horizontal accuracy of 8.23 m (rms). With resection using five ground-surveyed control points per image, the horizontal accuracy of reserved check points is 0.45 m (rms). Resections using the same

  5. Sustainable prevention of obesity through integrated strategies: The SPOTLIGHT project’s conceptual framework and design

    Directory of Open Access Journals (Sweden)

    Lakerveld Jeroen

    2012-09-01

    Full Text Available Abstract Background The prevalence of overweight and obesity in Europe is high. It is a major cause of the overall rates of many of the main chronic (or non communicable diseases in this region and is characterized by an unequal socio-economic distribution within the population. Obesity is largely determined by modifiable lifestyle behaviours such as low physical activity levels, sedentary behaviour and consumption of energy dense diets. It is increasingly being recognised that effective responses must go beyond interventions that only focus on a specific individual, social or environmental level and instead embrace system-based multi-level intervention approaches that address both the individual and environment. The EU-funded project “sustainable prevention of obesity through integrated strategies” (SPOTLIGHT aims to increase and combine knowledge on the wide range of determinants of obesity in a systematic way, and to identify multi-level intervention approaches that are strong in terms of Reach, Efficacy, Adoption, Implementation and Maintenance (RE-AIM. Methods/Design SPOTLIGHT comprises a series of systematic reviews on: individual-level predictors of success in behaviour change obesity interventions; social and physical environmental determinants of obesity; and on the RE-AIM of multi-level interventions. An interactive web-atlas of currently running multi-level interventions will be developed, and enhancing and impeding factors for implementation will be described. At the neighbourhood level, these elements will inform the development of methods to assess obesogenicity of diverse environments, using remote imaging techniques linked to geographic information systems. The validity of these methods will be evaluated using data from surveys of health and lifestyles of adults residing in the neighbourhoods surveyed. At both the micro- and macro-levels (national and international the different physical, economical, political and socio

  6. Coordinación de las protecciones de la subestación de distribución en la península de Santa Elena

    OpenAIRE

    Fernández Chicas, Robinson David; Espinel Encalada, José Leonidas; Aguilar Sánchez, Yasmani Leonardo; Saavedra Mera, Juan

    2014-01-01

    El presente trabajo desarrolla el estudio de la coordinación de protecciones aplicados a la subestación de distribución “SALINAS”, ubicada en la península de Santa Elena. Partiendo primero desde la descripción de las instalaciones, para conocer los elementos que la componen; posteriormente, se realiza un estudio de flujo de carga en condiciones de máxima y mínima carga y un estudio de cortocircuito de la subestación aplicados a la barra de 69kV y 13.8kV, esto nos servirá como datos preliminar...

  7. Spotlight: Zimbabwe.

    Science.gov (United States)

    Patriquin, W

    1988-04-01

    In Zimbabwe, a reproductive health survey conducted in 1984 revealed the highest rate of contraceptive use in sub-Saharan Africa -- 38% of currently married women were using some form of family planning and 27% a modern contraceptive method. The majority of Zimbabwe's population, a country formerly known a Rhodesia, is African, but there also are about 100,000 whites, 20,000 persons of mixed race, and 10,000 Asians. Robert Mugabe formed the 1st government of Zimbabwe as a result of elections held in February 1980. Since independence, rifts have developed between the black nationalist leaders -- Robert Mugabe and Joshua Nkomo -- and continues. Some guerrilla activity has occurred in rural areas and antigovernment dissidence creating security and economic problems. Zimbabwe has a broad range of natural resources -- large mineral deposits including coal, asbestos, copper, nickel, gold, and iron ore. In addition to a well-developed electrical power network, there is a good infrastructure of paved roads and a vital railroad link with neighboring South Africa. Due to the trade sanctions imposed between 1965 and independence, the country has had to look inward for production. The manufacturing sector is well developed as is agriculture. The government identifies the country's most urgent problems as the resettlement of displaced persons and reconstruction of roads, health establishments, and schools destroyed during guerrilla activity.

  8. Spotlight: Afghanistan.

    Science.gov (United States)

    Felt, J C

    1988-05-01

    Afghanistan is a landlocked country approximately the size of Texas with an estimated population of 14.5 million. The fertility level (6.7 children per women) is estimated to be very high, as is the mortality rate (183 infant deaths/1,000 live births). Demographic data sources are scarce, and current estimates are based on a 1972-1974 series of surveys and a 1979 census which enumerated only 55-60% of the population. The government of Afghanistan, a Marxist state, has asked for international aid to improve data collection and analysis. Compounding the problems of accurate data collection is the state of civil war that has existed in Afghanistan since the Marxist coup in in 1978 and Soviet occupation in 1979. The war impelled the emigration of 5 million refugees, who live in camps in neighboring Pakistan and Iran. Although the population decline that resulted from this emigration is significant, the repatriation of the refugees will play a role in determining the population dynamics for the next decade, as will the withdrawal of Soviet troops -- expected in 1990. Because of Afghanistan's central-Asia location, there is a unique ethnic and linguistic mixture of tribes. The largest group is the Pushtus, who make up 40% of the population. Afghan Persian and Pushtu are the dominant languages, and 98% of all Afghans are Moslem. The economy is largely agricultural and half the cultivated land must be irrigated. 85% of the population live in rural areas and another 2.5 million are nomads. The low status of women and female children, low levels of health care, and high fertility contribute to the lower life expectancy of females over males. Although the government supports contraceptive services, such services are inadequate, and sterilization is illegal. The withdrawal of Soviet troops and the possible end to civil war between the Kabul government and the rebel factions, and the effects of repatriation of refugees will determine the direction of Afghanistan's future development.

  9. Spotlight: Ecuador.

    Science.gov (United States)

    1998-04-01

    This article describes the vital statistics and population growth in Ecuador as of mid-1997. Mid-1997 population numbered about 12 million. Fertility was 3.6 births/woman; deaths were 6/1000 population; and births were 29/1000 population. Ecuador was primarily an agricultural country, until oil was discovered in the early 1970s. The country has worked to increase per capita income and confront environmental consequences. The capital city of Quito is situated in a valley between two mountains and has very high air pollution levels due to cars and factories. In contrast, indigenous populations live in the Andean mountains and farm small plots. Land shortages have pushed these farmers onto higher slopes and more marginal land that is becoming eroded. 22% of Ecuador's forests were cleared for farming during 1980-90. The city of Guayaquil, on the Pacific coast, has serious water pollution problems, sewage problems, and industrial pollution. Shrimp farming relies on high levels of fertilizer, which is damaging coastlines. Oil exploration in the interior of Ecuador, has resulted in disruption of indigenous population, loss of forests, and pollution of rivers. Texaco Oil is accused of spilling about 17 million gallons of crude oil, or 50 times more than the Exxon Valdez oil spill in Alaska. Texaco argues that it met government environmental standards and agreed to a cleanup, which only partially meets the standards of its critics. Oil resources have funded improvements in education and health. About 90% of Ecuador's adult population is literate. Fertility has declined, but the population is still largely young and will be entering their reproductive years by 2025.

  10. Pakistan. Spotlight.

    Science.gov (United States)

    Greene, M

    1985-01-01

    Focus in this discussion of Pakistan is on demographic factors, the issue of ethnic versus national solidarity, and economic and social development. The population was estimated at 99.2 million in 1985. The birthrate was 43/1000 in 1984 and the deaths were 15/1000. The infant mortality rate is 105 infant deaths/1000 live births, and life expectancy at birth is 51 years. In 1983 the gross national product per capita was US$390. The population of Pakistan is concentrated around Karachi on the Arabian Sea and in the crescent formed by Lahore, Rawalpindi, and Peshawar. Pakistan was a British colony, part of the Indian subcontinent until partition in 1947, when Britain gave Pakistan and India their freedom. Pakistan is not a theocracy, but the military government turns to traditional Islam for affirmation of its authority. Its martial law regime, established in 1977, is headed by President Ziaul Haq. The issue of ethnic versus national solidarity has been a problem since independence. Bengali-speaking East Pakistanis felt they did not have equal power in their country whose official language was Urdu and whose capital was in West Pakistan. East and West Pakistan ended up in armed conflict with the formation of Bangladesh in 1971 as the result. Regional and ethnic conflict is exacerbated by the low rate of literacy and the low status of certain ethnic groups in Pakistan. In addition, Pakistan suffers problems typical of many developing nations: a low per capita income, a large and growing population, and a highly stratified traditional society. In 1981 doctors, engineers, and craftsmen were in short supply, but there was a surplus of 300,000 agricultural workers. Agriculture makes up 30% of the GNP and employs 55% of the work force. In Pakistan's 6th Five Year Plan, initiated in July 1983, the government acknowledged for the 1st time the extremely poor conditions for women as indicated by literacy, health, and fertility. The total fertility rate is 6.4 average births/woman. Although the government is ostensibly trying to help women, funding for women's programs during the Five Year Plan was cut. Economic growth has been good in recent years, but agricultural growth is a result of increased acreage rather than yield per acre.

  11. Iran: spotlight.

    Science.gov (United States)

    Roudi, N

    1987-09-01

    Given its location between Asia and Asia Minor, Iran has been a country of strategic political importance throughout history. More than 98% of Iran's population is Moslem. During the early 20th century, as Iran gradually gained independence from the USSR and Turkey, a modernization process was begun. However, this modernization process was forced to yield to Islamic traditionalism after the 1979 Islamic Revolution. Women have been most affected by this change. The implementation of Islamic traditions has meant low job opportunity or motivation for continuing education among women. Although fertility remains high, the present government is satisfied with the current rate of population growth. Family planning is allowed if implemented within the framework of Islamic law, but abortion is illegal. Mortality fell substantially after World War II, but has not continued to decline. At present, both males and females have the same life expectancy at birth. Iran's population is growing at a rate of 4%/year, and can be expected to double in another 21 years. It has been projected that Iran, currently the 21st largest country in the world with a population of 50 million, will become the 15th largest with a population of 97 million by the year 2025. Tehran, the 20th largest city in 1985, is projected to be the 9th largest by the year 2000, with a population of 13.6 million.

  12. Spotlight: Malaysia.

    Science.gov (United States)

    Patriquin, W

    1988-03-01

    Focus is on Malaysia -- its population and land area, its total fertility rate and mortality rate, economic development, contraceptive usage, and population policy. In 1987 Malaysia's population was estimated to be 16.1 million with births 31/1000 population and deaths 7/1000 population. The rate of natural increase is 2.4%, the total fertility rate 3.9 children/woman, and the infant mortality rate 30/1000 live births. Ethnically, Malaysia is made up of several distinct groups. Indigenous Malays are the most numerous -- about 50% of the population. Their unique characteristics include that they are Moslem, rural, and usually of lower economic status. Chinese make up the 2nd largest group of Malaysians, nearly 1/3 of the population. This group is active in trade, business, and finance and possesses considerable economic power. About 10% of the population is of Indian descent. Malaysia has experienced much economic growth. Traditional exports grew in volume and value during the 1970; the petroleum sector expanded so rapidly it accounts for 1/4 of all exports. One reason for Malaysia's rapid economic growth is the government's promotion of industrialization and foreign investment. According to the 1982 contraceptive prevalence survey, 42% of currently married women 15-44 years were using contraception. The government considers the current rate of national increase to be satisfactory, but in 1984 it adopted a population policy to more than quadruple its population in 2100 to 70 million. It intends to accomplish this by instituting pronatalist incentives to help the fall in the national growth rate. The government's rationale for more population growth is that a larger domestic population could better support industrial growth that otherwise might be stymied by "protectionist policies practiced by developed countries." Incentives to encourage fertility include income-tax deductions and maternity benefits for women who have up to 5 children.

  13. Spotlight: Barbados.

    Science.gov (United States)

    1984-03-01

    Barbados was among the first to advocate a national system of family planning. In 1954 a joint committee report of birth legislation recommended the institution of a family planning system under the aegis of the government. The country's 1980 total fertility rate of 1.9 live births/woman attests to the success of the program. The rate is among the lowest of any developing nation. The population of Barbados was 122,298 at the 1st post emancipation census in 1844. In 1946 the population totaled 193,680. To a considerable extent, this very low rate of growth (0.46%) was due to substantial emigration, first to Trinidad and Guyana and later to countries outside the region such as the UK and more recently the US and Canada. Net emigration was so great between 1881 and 1921 that it exceeded natural increase by 54%. Consequently, the population declined from 182,867 to 156,724. By 1960, the population had reached 232,820, some 40,000 more than in 1946. Since then growth has been slow. Such a remarkably low rate of growth since World War 2 has been accomplished through continued high levels of emigration combined with declining fertility and mortality. The total fertility rate dropped from 4.7 in 1960 to 3.0 in 1970 to 1.9 in 1980. Life expectancy rose from about 50 in 1946 to 70 in 1980. Levels of net emigration have always been high and remain so. About 18,000 more persons left the country than entered it during the 1970s, a rate of 7.5/1000 population. While high, it is lower than in the 1960s. The mainstays of the economy are sugar and tourism. Since independence in 1966, sugar production has fallen steadily in response to depressed world sugar prices as well as increasing production costs. In recent years the government has sought to reduce dependence on the sugar industry. Tourism, adversely affected by the world recession, shows some signs of recovery. The discovery of some petroleum and natural gas may help. Barbados has one of the most developed infrastructures in the Caribbean and the government hopes to deal with current problems through diversification of the economy. As Barbados is the most densely populated country in the hemisphere, specialists agree that even a future population of 300,000 may be beyond the island's capacity. Because of high 1950s fertility, the labor force is expected to increase by 25% by the year 2000, a serious issue considering that current unemployment is already 14.7% After 2015, Barbados will be faced with an "elderly problem." Given its current demographic behavior, Barbados is in a better position to address and solve these problems than most developing countries.

  14. Spotlight: Azerbaijan.

    Science.gov (United States)

    1999-02-01

    As of mid-1998, Azerbaijan had a population of 7.7 million people residing in a land area of 33,436 square miles. There were 17 births and 6 deaths per 1000 population, as well as 19 infant deaths for every 1000 live births, and a population growing in size at 1.1% annually. The average woman had 2.1 births during her reproductive lifetime and life expectancy was 67 years for men and 74 years for women. Azerbaijan is an oil-producing country, although the agricultural sector is responsible for 25% of gross domestic product and employs 31% of the work force. Despite its oil wealth and strong agricultural and mining sectors, Azerbaijan is struggling to improve its environmental conditions and support a large refugee population. The country's air, water, and soil are severely polluted. Air pollution stems from petrochemical plants, refineries, exhaust fumes, and the burning of untreated garbage; water pollution is the result of oil spills, leaky pipelines and tanks, runoff of fertilizers and pesticides, and improperly treated sewage; and land pollution is due to inadequate waste management. The high incidence of waterborne diseases, including cholera, in Azerbaijan is caused by the inadequate treatment of drinking water and sewage intrusion into leaky distribution pipes. Although over 90% of infants under age 1 year are immunized against diphtheria, whooping cough, tetanus, polio, and measles, babies in Azerbaijan are 3 times as likely to die before reaching age 1 year than are babies in the US. Azerbaijani children are 5 times more likely to die by age 5 than are US children. Living conditions are especially difficult for the 12% of the overall population which are refugees.

  15. Spotlight: Vietnam.

    Science.gov (United States)

    1984-02-01

    Vietnam, with 57 million people, ranks as the world's 13th most populous country with much of the population concentrated in the rice producing areas of the coastal lowlands and the Mekong and Red River valleys. Since reunification, economic recovery has been difficult. Following the failure of the 1976-80 5-Year Plan, the 1981-85 Plan calls for increased food production and the attainment of self sufficiency. Part of this policy is the reduction of the population growth rate. Vietnam's labor force is about 70% agricultural, with women making up about 2/3 of the farm work force. Most heavy industry is in the North and, although badly damaged in the war, has regained much of its capacity. Coal continues to be Vietnam's leading export. The country's extensive forests also provide great potential for the lumber industry and Vietnam has recently begun offshore oil production. Yet, recovery has been elusive. Foreign aid now comes from the Soviet Union, China, Eastern Europe, and France. In recent years the foreign trade balance has improved, but there have been some setbacks in food production. Efforts to raise food production by encouraging private development of unused land have not been very successful, partly because of the continuing shortage of fertilizers, farm machinery, and insecticides. It is also likely that economic progress has been retarded by large military expenditures necessitated by the wars with Cambodia and China. 1 of the government's major efforts has been a large scale population redistribution from urban areas to the less densely inhabited provinces. New Economic Zones have been established in these areas in the hope that new residents will become self sufficient as soon as possible. As part of its national policy, the government has set a goal to reduce the rate of population growth to 1.5% by 1981 through the National Family Planning Program. Officially reported crude birthrates reflect a decline in fertility from about 40/1000 population in 1976 to about 29 in 1980.

  16. Global Monitoring of Mountain Glaciers Using High-Resolution Spotlight Imaging from the International Space Station

    Science.gov (United States)

    Donnellan, A.; Green, J. J.; Bills, B. G.; Goguen, J.; Ansar, A.; Knight, R. L.; Hallet, B.; Scambos, T. A.; Thompson, L. G.; Morin, P. J.

    2013-12-01

    Mountain glaciers around the world are retreating rapidly, contributing about 20% to present-day sea level rise. Numerous studies have shown that mountain glaciers are sensitive to global environmental change. Temperate-latitude glaciers and snowpack provide water for over 1 billion people. Glaciers are a resource for irrigation and hydroelectric power, but also pose flood and avalanche hazards. Accurate mass balance assessments have been made for only 280 glaciers, yet there are over 130,000 in the World Glacier Inventory. The rate of glacier retreat or advance can be highly variable, is poorly sampled, and inadequately understood. Liquid water from ice front lakes, rain, melt, or sea water and debris from rocks, dust, or pollution interact with glacier ice often leading to an amplification of warming and further melting. Many mountain glaciers undergo rapid and episodic events that greatly change their mass balance or extent but are sparsely documented. Events include calving, outburst floods, opening of crevasses, or iceberg motion. Spaceborne high-resolution spotlight optical imaging provides a means of clarifying the relationship between the health of mountain glaciers and global environmental change. Digital elevation models (DEMs) can be constructed from a series of images from a range of perspectives collected by staring at a target during a satellite overpass. It is possible to collect imagery for 1800 targets per month in the ×56° latitude range, construct high-resolution DEMs, and monitor changes in high detail over time with a high-resolution optical telescope mounted on the International Space Station (ISS). Snow and ice type, age, and maturity can be inferred from different color bands as well as distribution of liquid water. Texture, roughness, albedo, and debris distribution can be estimated by measuring bidirectional reflectance distribution functions (BRDF) and reflectance intensity as a function of viewing angle. The non-sun-synchronous orbit

  17. Efecto de variante de riego en la producción de maíz (zea mays l. En la Comuna Río Verde, cantón Santa Elena, Ecuador.

    Directory of Open Access Journals (Sweden)

    Ángel León

    2016-11-01

    Effect of irrigation variant in the corn production (Zea mays L. at Río Verde commune, Santa Elena, Ecuador. The test was conducted at the Production and Practice Center Río Verde, owned by the Santa Elena Peninsula State University, located in Río Verde commune, Santa Elena canton, the research aimed to evaluate the effect of irrigation variations into agronomic performance of corn under different irrigation sheets using as measuring tool evaporation A class Pan. The treatments were five doses of irrigation 60, 70, 80, 90 and 100% of evapotranspiration, treatments were placed in a complete randomized design of blocks with four replications, the averages compared with the Tukey test (p> 0.05. The regression analysis fits a quadratic equation and the coefficient of determination R2 0,91 which shows the high degree of dependence of results based on irrigation variants. The highest production was obtained by the treatment with 90% with 12,18 t.ha-1.

  18. María Elena: el fin de una experiencia urbana: Un estudio de caso en el desierto de Atacama, Chile

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    JUAN CARLOS RODRÍGUEZ TORRENT

    2009-08-01

    Full Text Available En el presente trabajo se plantea la relación entre la ciudad salitrera de María Elena (II Región, diseñada de acuerdo a propuestas utópicas en un territorio privado, y el cambio de las relaciones laborales entre la Compañía SQM y los trabajadores a partir del predominio de un nuevo modelo de acumulación cuyos ejes están dados por la competitividad, la producción de calidad y la globalización. La ciudad fue creada para que hombres y mujeres construyeran sus proyectos de vida en medio del Desierto de Atacama, ofreciéndoles todas las garantías y la infraestructura para que ello fuese así en los marcos de una política de pleno empleo, de modo de contener a la población en un medio inhóspito, cumplir los objetivos productivos y fortalecer una identidad coherente y cohesionada, lo que a partir de nuevas decisiones estratégicas es substituido por un modelo de flexibilidad laboral, lo que anula su definición primigenia y el interés colectivo para comenzar a dar paso a un campamento minero.In this paper we look into the relationship between the nitrate town of Maria Elena (in Region II - designed on Utopian principals as a private project - and the changing labor relations between the SQM Company and the workers as a result of the predominance of a new accumulation model guided by competitiveness, quality production and globalization. The town was created so that men and women could establish their livelihoods in the Atacama Desert, with guarantees and infrastructure based on a full employment policy. This was in order to anchor the population in this inhospitable environment, to meet production objectives and to strengthen a coherent and cohesive identity. New strategic decisions led to this model being replaced by one based on labour flexibilization, deleting its original intention and collective interest to give way to a mining camp.

  19. Bildung, Erziehung [education] and care in German early childhood settings – spotlights on current discourses

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    Frindte Annegret

    2017-08-01

    Full Text Available In German there is a long tradition of institutionalized daycare center-based early education. These institutions are concerned with Bildung, Erziehung und Betreuung - the education and care of children up to six years of age. Education and childrearing as well as care are all important but separate processes in German early childhood settings. Looking back, this theoretical division has a very long tradition. However, the energized public, political and professional discussions about the PISA results at the beginning of the 21st century led to Bildung and ECEC settings becoming increasingly important. Taking into account this complex and difficult historical development it is interesting to have a critical look at the dominant programmatic frames that characterize the German ECEC system nowadays: Bildung and quality of early education. The former double motif of education (Bildung und Erziehung on the one hand and care (Betreuung on the other hand remains an important aspect of German ECEC practices. Nevertheless, in the political arena and professional discourses Erziehung and Betreuung have been pushed into the background, to remain in symbolic form. Bildung and quality of early education seem to be in the spotlight. We will show how those programmatic frames have taken shape and are manifested in early childhood programs and projects.

  20. Comparison of polar formatting and back-projection algorithms for spotlight-mode SAR image formation

    Science.gov (United States)

    Jakowatz, Charles V., Jr.; Doren, Neall

    2006-05-01

    The convolution/back-projection (CBP) algorithm has recently once again been touted as the "gold standard" for spotlight-mode SAR image formation, as it is proclaimed to achieve better image quality than the well-known and often employed polar formatting algorithm (PFA). In addition, it has been suggested that PFA is less flexible than CBP in that PFA can only compute the SAR image on one grid and PFA cannot add or subtract pulses from the imaging process. The argument for CBP acknowledges the computational burden of CBP compared to PFA, but asserts that the increased image accuracy and flexibility of the formation process is warranted, at least in some imaging scenarios. Because CBP can now be sped up by the proper algorithm design, it becomes, according to this line of analysis, the clear algorithm of choice for SAR image formation. In this paper we reject the above conclusion by showing that PFA and CBP achieve the same image quality, and that PFA has complete flexibility, including choice of imaging plane, size of illuminated beam area to be imaged, resolution of the image, and others. We demonstrate these claims via formation of both simulated and real SAR imagery using both algorithms.

  1. Energía Undimotriz, alternativa para la producción de Energía Eléctrica en la Provincia de Santa Elena

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    Rolando Calero

    2015-10-01

    Full Text Available La energía undimotriz, es la energía que permite obtener electricidad a partir de energía mecánica generada por el movimiento de las olas. Es uno de los tipos de energías renovables con más recientes estudios, y presenta enormes ventajas frente a otras energías renovables debido a que se tendría mayor facilidad para predecir condiciones geológicas óptimas que permitan la mayor eficiencia en sus procesos. Debido a que es más fácil llegar a predecir condiciones óptimas de oleaje, en comparación con la obtenida con  los vientos para obtener energía eólica, donde su variabilidad es menor.En este trabajo se espera aportar y dilucidar con datosespecíficos sobre la morfología de la zonamarítima en la provincia de Santa Elena, tratando depredecir si las características propias del lugar son idóneas  para producir electricidad en base a la implementación de energíaundimotriz, como fuente renovable no convencional utilizando las tecnologías actuales para este propósito.

  2. Minería de datos con técnica cluster, caso de estudio: estudiantes de Universidad Estatal Península de Santa Elena.

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    Mariuxi De La Cruz

    2015-10-01

    Full Text Available Este trabajo fue realizado para la Universidad Estatal Península de Santa Elena, muestra el proceso de minería de datos aplicando la técnica cluster o conglomerado, con herramientas de software libre como: PostgreSQL, apropiada para el almacenamiento de los datos y R para el análisis estadístico y la generación de los algoritmos que implica la técnica. El análisis cluster fue implementado en datos sociales, económicos y académicos de los estudiantes inscritos en la Facultad de Sistemas y Telecomunicaciones de esta institución de educación superior. El proceso es detallado en tres secciones, la primera donde se describe los conceptos  asociados a minería de datos, técnica cluster y las herramientas tecnológicas utilizadas para explotación de información. En la segunda sección  se describe el proceso de aplicación la técnica cluster con el método particional y con el método jerárquico. En la sección tres se muestra los conglomerados obtenidos al aplicar la técnica en el grupo de datos. Finalmente se presentan las conclusiones y recomendaciones de este trabajo.

  3. Estudio sobre la Salud y Nutrición de los Estudiantes de la Universidad Estatal Península de Santa Elena

    Directory of Open Access Journals (Sweden)

    Karina Bricio

    2015-10-01

    A good physical activity with a good performance in all environments depends on the nutritious habits and good health that this represents, In fact universities today care about the quality of the education and keeping its healthy students; which is part of the teaching activities also having obligation to inculcate healthy habits within their study programs, and thereby to promote a healthy lifestyle. The objective of this research is to analyze which is the current state of health, and the types of foods consumed by the students of the state university of Santa Elena Peninsula UPSE, to determine strategies and to be able to implement campaigns and talks about health and nutrition. The investigation determined that the students are not feeding well, due to the fact that their diets do not incorporate, fruits, vegetable, and not taking any vitamin supplement, in addition it is analyzed that have a high stress problem, and generally are always suffering from gastritis. The diet should be balanced which these provides a positive balance to our body.

  4. Caracterización de un Andisol de la cuenca alta de la quebrada Santa Elena, Oriente Antioqueño, Colombia.

    Directory of Open Access Journals (Sweden)

    Nicolás Pérez Echavarría

    2017-01-01

    Full Text Available Se caracterizó detalladamente un Andisol derivado de ceniza volcánica de la cuenca alta de la quebrada Santa Elena, Oriente Antioqueño (Colombia, con el fin de realizar en él otros estudios más detallados de pedogénesis. El suelo estudiado presentó un bajo contenido de bases y de fósforo disponible y una alta acidez, lo que indica un bajo nivel de fertilidad natural. El alto contenido de materia orgánica superficial está en concordancia con el clima frío húmedo de la zona y con la formación de complejos organometálicos que la protegen de la mineralización. Los horizontes superficiales del perfil estudiado se clasificaron como no alofánicos mientras que los horizontes subsuperficiales se clasificaron como alofánicos. El suelo estudiado mostró evidencias de ser poligenético, así como de fenómenos de erosión asociados a cambios climáticos drásticos y fue clasificado como un Acrudoxic Fulvudand, medial, mezclado, isotérmico.

  5. "This one is stronger". Spotlights on the lifelong learning professional-in-action

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    Josje van der Linden

    2016-06-01

    Full Text Available ABSTRACT“This one is stronger.” Spotlights on the lifelong learning professional-in-action Around the world, lifelong learning is being promoted as a strategy for coping with the changing realities of life and work. The fourth Sustainable Development Goal, agreed in September 2015, reflects this: “ensure equitable and inclusive quality education and promote lifelong learning opportunities for all”. Despite its importance, doubts remain about the implementation of this goal in practice (Van der Kamp, 2000; Regmi, 2015. This article looks at the practice of lifelong learning from the point of view of the professionals involved, their actions and the way these actions are challenged, supported and further developed. Following Schön’s “reflection-in-action” (1983, the term “professional-in-action” is used to stress the role of the professional in making the difference on the ground. The leading question is: how can lifelong learning professionals be supported in their contribution to surrounding society and its citizens? The professionals-in-action featured in this article include professionals based in the Netherlands as well as in other, less privileged contexts. Meaningful experiences are used to build a story about challenges, the right to exist, commitment, recognition and room to manoeuvre. The experiences reveal the importance of interacting with the learner and the professional space that is necessary to achieve this. Professionalization in professional learning communities and practice-oriented research must accompany this professional space. SAMENVATTING“Deze is sterker”. Spotlights op de leven lang leren professional-in-actieOm te kunnen omgaan met de veranderende realiteit in leven en werk, wordt wereldwijd een leven lang leren aangemoedigd. Het vierde duurzame ontwikkelingsdoel, vastgesteld in september 2015, weerspiegelt dit: “het verzekeren van kwalitatief goed onderwijs en het bevorderen van de mogelijkheden

  6. Putting the learner in the spotlight – Future directions for English teachers

    Directory of Open Access Journals (Sweden)

    Anne P A Swan

    2013-10-01

    Full Text Available This paper asserts that English teachers’ understanding of their professionalism enables them to ‘put the learner in the spotlight’ through their highly-developed awareness of local contexts of English use. Changing attitudes to English language teacher identity include a revaluation of the’ native-non-native speaker’ dichotomy which is fast becoming irrelevant as teachers assert new identities based on factors such as professional beliefs about their teaching, understanding their students’ needs and understanding the role of English in their contexts. In a globalising world, these aspects no longer require ‘so-called’ native speaker skills, such as pronunciation and knowledge of ‘English’ culture. In fact, dwelling at length on the issues surrounding native and non-native speaker teacher identity tends to cloud understanding of what qualities English teachers need. Interviews with multilingual teachers of English, working in a variety of countries, have revealed an understanding of the diminishing importance of the ‘native speaker’ and the concomitant growth in the confidence of the multilingual teacher. This confidence has been acquired through depth of linguistic knowledge, through observance of other cultures, and through resistance to the encroachment of English by finding a place for the language which satisfies the needs of multilingual users without requiring subservience. In discovering these strengths of multilingual teachers, I show how stepping outside the boundaries of one’s own limited environment allows English language teachers, wherever they come from, to develop a truly enlightened international professionalism which puts learners firmly in the spotlight.

  7. Las reformas al impuesto al valor agregado y su efecto en la economía del consumidor en la provincia de Santa Elena. Año 2016

    Directory of Open Access Journals (Sweden)

    Nelson Asencio Cristóbal

    2017-05-01

    Full Text Available El objetivo del presente reporte es elaborar un análisis de las reformas tributarias del IVA implementadas en el país en el año 2016 y referir su  impacto en la economía del consumidor en la provincia de Santa Elena. Desde una perspectiva teórica, se define la estructura impositiva del país y su importancia en la generación de ingresos públicos para la consecución objetivos sociales; así como también los fines que conllevan las reformas tributarias tendientes a regular la economía, fomentar el empleo, incentivar la producción, la demanda y el consumo. En la investigación que dio origen a este artículo se aplicaron procedimientos metodológicos  deductivo, cuantitativo, y documental provenientes de fuentes oficiales y  técnicas de investigación que permitieron obtener información relevante para el análisis descriptivo  de las reformas, cuyos resultados reflejan la necesidad de que el gobierno, previa a la adopción de estas medidas,  realice con profundidad un estudio  socio-económico, que permita valorar las incidencias que tendrían en el sector productivo del país y en el consumido específicamente.  En la investigación se describen las últimas reformas tributarias del IVA para luego referir su efecto general en el consumo de bienes y servicios del consumidor peninsular.   Abstract The objective of the present report is to develop an analysis of VAT tax reforms implemented in the country in the year 2016 and see its impact on the economy of the consumer in the province of Santa Elena. From a theoretical perspective, defines the country's tax structure and its importance in the generation of revenue to achieve social objectives; as well as also the purposes involving tax reforms aimed at regulating the economy, promoting employment, encourage the production, demand and consumption. In the research that gave origin to this article is applied procedures methodological deductive, quantitative, and documentary from of

  8. WITH THE DIFFERENCE OF HALF A CENTURY OR TWO ESOTERIC CONCEPTS OF SOCIAL FINALISM (BASED ON THE WORKS OF ELENA BLAVATSKAYA AND DANIEL ANDREEV

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    Maria Vladimirovna Privalova

    2015-09-01

    Full Text Available In this article the author makes a comparative analysis of two concepts of social finalism formulated with the difference of fifty years. Researchers consider.both authors to be esoteric thinkers. Daniel Andreev was fascinated with the doctrine of Elena Blavatskaya. That’s the main reason why the finalistic concepts of the above-mentioned authors are examined as interrelated ones. The definition of «social finalism» is given in the article. According to classical interpretation of the concept, finalism (from Lat. Finalis means final, being the final goal. So, under this concept the author understands the achievement of a certain final level of social development, according to the goals. Each thinker offers his/her own goals and ways of achieving, the analysis of finalistic concepts helps to identify the most common and often allocated by philosophers, and hence universal goals, ways, means and conditions; which are, in our opinion, the ones reflecting the true preferences of mankind in the choice of the future for people themselves and their descendants. In this case, the esoteric concepts are analyzed. This fact in the author’s opinion is quite relevant, since the number of people who position themselves as adherents of esoteric teachings is steadily increasing. In the social finalistic concept of Blavatskaya the purpose – «brotherhood of all mankind», means of achieving – the Duty, Mercy, Self-sacrifice, and obstacles to the achievement of the final stage of society today are considered. The article shows that all necessary changes to achieve the ideal state of society, according to Andreev, should be carried out in all spheres of public life. This study will help to understand the aspirations and hopes for social transformations of people practicing esoteric approach to the perception of life.

  9. Modelos explicativos del cambio en la cobertura del suelo en el crecimiento del uso urbano de la provincia de Santa Elena - Ecuador

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    Dany Salazar

    2016-11-01

    Full Text Available En el año 2009, el gobierno vigente del Ecuador plantea a los gobiernos autónomos descentralizados, los requerimientos de una planificación y ordenamiento en sus respectivos territorios, para que su uso sea sostenible. Por ende, la demanda de insumos de información estadística y geográfica ha sido una prioridad dentro de este ámbito gubernamental. Así tenemos que, la presente contribución investigativa propone brindar insumos de información que de soporte a la planificación y ordenamiento territorial de la Provincia de Santa Elena, Área de Planificación Nº 5 - Ecuador. Siendo uno de los insumos prioritarios la identificación de factores explicativos que inciden en el crecimiento urbano, tales como el biofísico, socioeconómico y de accesibilidad. Para ello se ha seleccionado como unidad de mínima integración de información al pixel y como técnica estadística Regresión Logística. Entre los principales resultados tenemos la implementación de la estandarización, bajo el criterio lineal decreciente para la homogenización de las variables de accesibilidad potenciando al modelo seleccionado y la utilización de herramientas potentes de las Tecnologías de la Información Geográfica, que ha permitido la implementación de modelos con volumen significativo de datos.

  10. Estimación de la demanda energética mensual mediante encuesta aplicada en la provincia de Santa Elena

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    Christian Pavón

    2015-12-01

    Full Text Available En el dimensionamiento óptimo de una micro red es de mucha importancia identificar en el lugar de estudio, el potencial energético renovable y la demanda de consumo energético mensual de las familias. El presente trabajo muestra la metodología y resultados de una encuesta de consumo de energía eléctrica que se aplicó in situ a una muestra de la población de hogares de la parroquia rural Atahualpa, provincia de Santa Elena. Luego, estos resultados recopilados fueron tabulados y procesados; y se estimó, mediante estadísticas de muestreo, la demanda de energía eléctrica promedio mensual de viviendas. El consumo mensual de energía eléctrica para viviendas familiares fue de 195 kWh y viviendas de negocio de 446 kWh. El consumo mensual per cápita familiar fue de 39 kWh. Finalmente, este estudio evidencia la importancia de la metodología y resultados obtenidos, los cuales pueden servir para tomar decisiones del ámbito energético tanto a nivel de región, como a nivel de país, mediante políticas públicas adecuadas para abordar el problema de una mejor redistribución energética.

  11. Single-Side Two-Location Spotlight Imaging for Building Based on MIMO Through-Wall-Radar

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    Yong Jia

    2016-09-01

    Full Text Available Through-wall-radar imaging is of interest for mapping the wall layout of buildings and for the detection of stationary targets within buildings. In this paper, we present an easy single-side two-location spotlight imaging method for both wall layout mapping and stationary target detection by utilizing multiple-input multiple-output (MIMO through-wall-radar. Rather than imaging for building walls directly, the images of all building corners are generated to speculate wall layout indirectly by successively deploying the MIMO through-wall-radar at two appropriate locations on only one side of the building and then carrying out spotlight imaging with two different squint-views. In addition to the ease of implementation, the single-side two-location squint-view detection also has two other advantages for stationary target imaging. The first one is the fewer multi-path ghosts, and the second one is the smaller region of side-lobe interferences from the corner images in comparison to the wall images. Based on Computer Simulation Technology (CST electromagnetic simulation software, we provide multiple sets of validation results where multiple binary panorama images with clear images of all corners and stationary targets are obtained by combining two single-location images with the use of incoherent additive fusion and two-dimensional cell-averaging constant-false-alarm-rate (2D CA-CFAR detection.

  12. Parque temático turístico cultural como alternativa de diversificación de la oferta turística en la ciudad de Santa Elena.

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    Mercedes Freire Rendón

    2017-05-01

    Full Text Available El turismo de sol y playa es el segmento que genera mayor flujo de turistas y representa un motor importante para el desarrollo de la actividad en muchos países. Sin embargo, el hacinamiento, el deterioro ambiental, los cambios en la demanda y el aumento de la competencia han generado preocupación por el futuro de los destinos consolidados de sol y playa. Dada esta afirmación, y siendo Santa Elena una localidad con estas características, se hace relevante buscar alternativas de diversificación de la oferta turística que permitan dinamizar procesos de desarrollo sostenible del sector. El Objetivo de esta investigación, consiste en determinar el parque temático turístico cultural como alternativa de diversificación de la oferta turística en la ciudad de Santa Elena. La metodología utilizada se basó en un enfoque cualitativo-cualitativo apoyado en la recolección de datos con el diseño de entrevistas en profundidad con actores comunitarios como informantes clave para determinar las categorías a evaluar y establecer elementos esenciales del diagnóstico. Los principales resultados determinaron que en la ciudad de Santa Elena a pesar de la existencia del museo Amantes de Sumpa con enfoque cultural no hay lugar o atracción turística con temática que relacione lo recreativo y cultural, representando costumbres y tradiciones locales para la satisfacción de los visitantes.   Abstract The tourism of sun and beach is the segment that generates greater flow of tourists and represents an important motor for the development of the activity in many countries. However, overcrowding, environmental deterioration, changes in demand and increased competition have generated concern about the future of consolidated sun and beach destinations. Given this assertion, and being Santa Elena a locality with these characteristics, it becomes relevant to look for alternatives of diversification of the tourist supply that allow to dynamize processes of

  13. Proyecto de producción, comercialización y exportación de artesanías de paja toquilla en la península de Santa Elena

    OpenAIRE

    Rojas Cruzatti, Margarita; Sisalema Morejon, Lila

    2009-01-01

    Las artesanías en paja toquilla han estado presentes en el Ecuador desde 1700. La Península de Santa Elena presenta excelentes condiciones climáticas para el desarrollo de una agricultura empresarial y económicamente autosuficiente, permitiendo la implantación de un grupo muy amplio de cultivos. El producto que más se demanda es el sombrero de paja toquilla, cuya producción se destina un 10% al mercado local, y el restante 90% al mercado mundial, de acuerdo al Banco Central del Ecuador. ...

  14. Elena de Miguel Aparicio El aspect en la sintaxis del Español perfectividad e impersonalidad Ediciones de Ia Universidad Autónoma de Madrid, 1992, p. 264.

    Directory of Open Access Journals (Sweden)

    Jasmina Markič

    1993-12-01

    Full Text Available No son muchas las obras destinadas en su totalidad al estudio del aspecto en español por lo que la publicación dellibro de Elena de Miguel Aparicio llama tanto más la atención especialmente en nuestro · ambiente lingüistico eslavo di:mde el aspecto, como es sabido, tiene una importancia especial. La autora se dedica al estudio del aspecto como categoría independiente del tiempo desde una perspectiva oracional utilizando el modelo actual de la gramática generativa denominado Rección y Ligamiento.

  15. Impacto cultural de los proyectos de desarrollo. Parque Regional Ecoturístico Arví. Corregimiento de Santa Elena, municipio de Medellín: Propuesta de evaluación

    OpenAIRE

    Ocampo Madrigal, John Jader

    2015-01-01

    Resumen: se analiza la alteración de la dinámica cultural con la inclusión del proyecto de desarrollo Parque Regional Ecoturístico Arví en el corregimiento de Santa Elena – Medellín, en el marco de entendimiento del concepto de configuración cultural, a través de cuatro indicadores cualitativos relacionados con la comprensión del territorio, las redes culturales, la actitud social frente a los espacios públicos y la percepción patrimonial. Los resultados de esta tarea, fueron evaluados a la l...

  16. Evaluación de ideas irracionales en los postulantes de diversas carreras que oferta la Universidad Estatal Península de Santa Elena en el segundo semestre del periodo 2013 – 2014

    OpenAIRE

    Rocío Ponce

    2015-01-01

    La presente investigación realizada en la Universidad Península de Santa Elena evalúa los sistemas de creencias que se vienen incrementando en las carreras sociales y tecnológicas en las que el sentido de valores es importante e indispensable, los postulantes de las ocho carreras ofertadas tales como Contadores Públicos, Enfermería, Turismo, Informática, Ingeniería civil, ingeniería en petróleos, Administración y Biología Marina mantienen sistemas de creencias puede incidir en el rendimiento ...

  17. Space-variant post-filtering for wavefront curvature correction in polar-formatted spotlight-mode SAR imagery

    Science.gov (United States)

    Doren, Neall Evan

    Wavefront curvature defocus effects occur in spotlight-mode SAR imagery when reconstructed via the well-known polar-formatting algorithm (PFA) under certain imaging scenarios. These include imaging at close range, using a very low radar center frequency, utilizing high resolution, and/or imaging very large scenes. Wavefront curvature effects arise from the unrealistic assumption of strictly planar wavefronts illuminating the imaged scene. This dissertation presents a method for the correction of wavefront curvature defocus effects under these scenarios, concentrating on the generalized, squint-mode imaging scenario and its computational aspects. This correction is accomplished through an efficient one-dimensional, image domain filter applied as a post-processing step to PFA. This post-filter, referred to as SVPF, is precalculated from a theoretical derivation of the wavefront curvature effect and varies as a function of scene location. Prior to SVPF, severe restrictions were placed on the imaged scene size in order to avoid defocus effects under these scenarios when using PFA. The SVPF algorithm eliminates the need for scene size restrictions when wavefront curvature effects are present, correcting for wavefront curvature in broadside as well as squinted collection modes while imposing little additional computational penalty for squinted images. This dissertation covers the theoretical development, implementation and analysis of the generalized, squint-mode SVPF algorithm (of which broadside-mode is a special case) and provides examples of its capabilities and limitations as well as offering guidelines for maximizing its computational efficiency. Tradeoffs between the PFA/SVPF combination and other spotlight-mode SAR image formation techniques are discussed with regard to computational burden, image quality, and imaging geometry constraints. It is demonstrated that other methods fail to exhibit a clear computational advantage over polar-formatting in conjunction

  18. Space-Variant Post-Filtering for Wavefront Curvature Correction in Polar-Formatted Spotlight-Mode SAR Imagery

    Energy Technology Data Exchange (ETDEWEB)

    DOREN,NEALL E.

    1999-10-01

    Wavefront curvature defocus effects occur in spotlight-mode SAR imagery when reconstructed via the well-known polar-formatting algorithm (PFA) under certain imaging scenarios. These include imaging at close range, using a very low radar center frequency, utilizing high resolution, and/or imaging very large scenes. Wavefront curvature effects arise from the unrealistic assumption of strictly planar wavefronts illuminating the imaged scene. This dissertation presents a method for the correction of wavefront curvature defocus effects under these scenarios, concentrating on the generalized: squint-mode imaging scenario and its computational aspects. This correction is accomplished through an efficient one-dimensional, image domain filter applied as a post-processing step to PF.4. This post-filter, referred to as SVPF, is precalculated from a theoretical derivation of the wavefront curvature effect and varies as a function of scene location. Prior to SVPF, severe restrictions were placed on the imaged scene size in order to avoid defocus effects under these scenarios when using PFA. The SVPF algorithm eliminates the need for scene size restrictions when wavefront curvature effects are present, correcting for wavefront curvature in broadside as well as squinted collection modes while imposing little additional computational penalty for squinted images. This dissertation covers the theoretical development, implementation and analysis of the generalized, squint-mode SVPF algorithm (of which broadside-mode is a special case) and provides examples of its capabilities and limitations as well as offering guidelines for maximizing its computational efficiency. Tradeoffs between the PFA/SVPF combination and other spotlight-mode SAR image formation techniques are discussed with regard to computational burden, image quality, and imaging geometry constraints. It is demonstrated that other methods fail to exhibit a clear computational advantage over polar-formatting in conjunction

  19. Incidencia del estilo de vida en el rendimiento académico de los estudiantes, mediante un análisis interno en la Universidad Estatal Península de Santa Elena UPSE, de la provincia de Santa Elena año 2014.

    Directory of Open Access Journals (Sweden)

    Karina Bricio

    2015-10-01

    The present investigation has as objective to evaluate the incidence of the lifestyle in the academic yield of the students of the University State Peninsula of Santa Elena UPSE, the project is framed in knowing the lifestyles of the students that activities make in their free times, and in many of the cases because its academic yield diminishes, by means of technical of observation and interviews it was determined that the students spend stressed, they don't take a healthy lifestyle, they carry out little sport, they pass navigating in the social nets, they like to see the television a lot, and they dedicate few hours to study. It is for it the importance and the development of this project to give to know to the authorities that make their students outside of the university and in that use their free times. The methodology that you applies was of two types, quantitative and qualitative investigation, between the results of the analysis of the questionnaires and the focus groups, was determined that the students dedicate two hours to study, they don't sometimes attend classes for illness, laziness, or they are sleeping, they like to play soccer, to leave to parties, they consume alcoholic drinks, they consume tobacco, they navigate two hours and more in the social nets, they travel little for lack of resources, and in most of the cases they don't have breakfast, they read little, which affects its academic yield in great measure.

  20. Fortalecimiento del sector de la soldadura en la Provincia de Santa Elena a través de actividades del Centro de Capacitación de Soldadura LINDE-UPSE

    Directory of Open Access Journals (Sweden)

    Jorge Lucin

    2015-10-01

    Abstract The generation of grands projects that the country has, in its execution bears the important contribution of technical work such as welding. The University Santa Elena Peninsula, UPSE and multinational LINDE, ex AGA S.A.,  in order to strengthen the area of welding work in the province of Santa Elena, have signed a cooperation agreement with a duration of 5 years. For this purpose, is installed, an Training Center first order with equipment, machinery, tooling and supplies needed to offer quality work. Physical resources are given to UPSE, while knowledge and technique gives the multinational facilitator through highly qualified instructor.  The courses   to offering are approbation. The work is organized upon circulation, registration, training, evaluation, approval and final reports for each course, which is based on the statistics and media documents. Thus, over the first 3 years of work, has trained 229 people, with a total of 240 hours in 12 basic curs for welders support. Representative institutions in these works have been favored by updating technical knowledge and taught at the Center. The agreement remaining 1.5 years to finish but given its fruitful work, surely renew contributions towards this important technical work such as welding.

  1. INCIDENCIA DE LOS SISTEMAS DE CONTROL CONTABLE EN LA GESTION ADMINISTRATIVA DE LAS EMPRESAS PRIVADAS EN LA PROVINCIA DE SANTA ELENA AÑO 2014

    Directory of Open Access Journals (Sweden)

    Karina Bricio

    2016-04-01

    Full Text Available La presente investigaciones tiene como objetivo evaluar la incidencia de los  sistemas de control contable en la gestion administrativa de las emoresas privadas en la provincia de Santa Elena, el proyecto está enmarcado dentro del área de gestion administrativa, comunicación organizacional, control contable, informes financieros, control de registros contables, entre otros, se han venido desarrollando desde hace años los procesos administrativos de una manera manual y se han implementadi sistemas de control financieras, sin embargo en las empresas ecuatorianas la contabilidad se ha convertido en  una tecnica que se ocupa de registrar, clasificar y resumir las operaciones mercantiles de un negocio con el fin de interpretar sus resultados. Por consiguiente los gerentes o directores através de la contabilidad podrán orientarse sobre el curso que siguen sus negocios mediante sistemas o software contable. Los resultados podrán orientarse sobre el curso que siguen sus negocios y conocer las estabilidad y solvencia de la compañia, la corriente de cobros y pagos, las  tendencias de las ventas, costos y gastos  generales, con la técnica de observacion y mediantes entrevistas se determinó que en muchas empresas de provincia no hay sistemas de controles contables, el cual no manejan de forma eficiente los procesos contables ni administrativos, tambien se observó que se utilizó para el analisis correspondiente fue de tipo cuantitativo el cual se realizó encuestas a las personas que trabajan en las areas  administrativas de las empresas de la provincia, entre los resultados encontrados se mecniona lo siguiente: los  sistemas de control contable que utilizan actualmente las empresas son, el sistema Mónica, sistema Sagitario, el sistema Siscom,mennioaron tambien que la falta de sistemas de control contable retrasa la gestion administrativa de le empresa, necesitan cursos de capacitaciones y actualizaciones en temas de tributacion, sistemas

  2. Compositional diversity in peridotites as result of a multi-process history: The Pacific-derived Santa Elena ophiolite, northwest Costa Rica

    Science.gov (United States)

    Escuder-Viruete, Javier; Baumgartner, Peter O.; Castillo-Carrión, Mercedes

    2015-08-01

    The Santa Elena ophiolite (SEO) is an ultramafic nappe of more than 270 km2 overlying a tectonic serpentinite-matrix mélange in northwest Costa Rica. It is mainly composed of Cpx-rich and Cpx-poor harzburgites (~ 2.5 km-thick), with minor lherzolite, dunite and chromitite, as well as intrusive mafic sills and subvertical dikes, which coalesce into an upper Isla Negritos gabbroic sill complex. Minerals and whole-rock features of the Cpx-rich and Cpx-poor harzburgites share features of the abyssal and supra-subduction zone (SSZ) peridotites, respectively. To explain these characteristics two-stages of melting and refertilization processes are required. By means of trace element modeling, the composition of Cpx-rich harzburgites may be reproduced by up to ~ 5-10% melting of a primitive mantle source, and the composition of Cpx-poor harzburgites and dunites by ~ 15-18% melting of an already depleted mantle. Therefore, the Cpx-rich harzburgites can be interpreted as product of first-stage melting and low-degrees of melt-rock interaction in a mid-ocean ridge environment, and the Cpx-poor harzburgites and dunites as the product of second-stage melting and refertilization in a SSZ setting. The mafic sills and the Isla Negrito gabbros are genetically related and can be explained as crystallization from the liquids that were extracted from the lower SSZ mantle levels and emplaced at shallow conditions. The Murciélagos Island basalts are not directly related to the ultramafic and mafic rocks of the SEO. Their E-MORB-like composition is similar to most of the CLIP mafic lavas and suggests a common Caribbean plume-related source. The SEO represents a fragment of Pacific-derived, SSZ oceanic lithosphere emplaced onto the southern North America margin during the late Cretaceous. Because of the predominance of rollback-induced extension during its history, only a limited amount of crustal rocks were formed and preserved in the SEO.

  3. Legend tummast abilisest / Elena Lass

    Index Scriptorium Estoniae

    Lass, Elena

    2003-01-01

    PÖFFi Suvekino raames näidati Tallinna Linnaarhiivi siseõues saksa tummfilmi programmi "Öised varjud". Paul Wegeneri ja Carl Boese 1920. a. valminud filmile "Golem, kuidas ta maailma tuli" tegid saatemuusikat Marianne Kõrver, Rainer Jancis ja Raoul Kurvitz

  4. Aplicación del Diagnóstico Morfofuncional de la Población Estudiantil comprendida en dos Planteles Educativos en edades de 6 a 12 años en las Escuelas Teodoro Wolf y Escuela N°13 Ballenita del Cantón Santa Elena de la Provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Katherine Aguilar

    2015-10-01

    Full Text Available Son numerosos los estudios que han surgido ligados a la cineantropometría desde su aparición como ciencia, con un cuerpo doctrinal propio, en el Congreso Internacional de la Actividad Física de Montreal en 1976 (Chamorro, 1993. Como nos señala la Sociedad Internacional para el Avance de la Kinantropometría (ISAK, 2001, los estudios antropométricos incluyen una serie de herramientas con cómputos diversos para el análisis de datos, tales como el somatotipo, el fraccionamiento de la masa corporal, estimaciones de la proporcionalidad o la predicción de la densidad corporal con diversas ecuaciones de regresión. Desde esta última perspectiva, Norton et al. (2004 señalan que dentro del amplio número de factores que influyen en el rendimiento deportivo, las medidas antropométricas en un deportista son variables que pueden jugar un rol importante en la determinación del éxito potencial en determinados deportes. Estos mismos autores, indican la necesidad de estudiar los perfiles morfológicos de los mejores deportistas de cada especialidad. De ahí que el objetivo de este estudio sea obtener un perfil morfológico de referencia, centrándose en el somatotipo y la composición corporal de la población estudiantil de ocho colegios de la Provincia Santa Elena con edades comprendidas de los 11 a 15 años

  5. Elaboración de hormigones que minimicen el impacto al ambiente, empleando neumáticos usados de vehículos livianos y pesados, en la provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Armando Saltos

    2016-04-01

    En su segunda etapa se realizará el diseño de hormigón incluyendo las partículas de neumáticos triturados, en el que se dará a conocer cuál es el porcentaje óptimo que se incluirá este material con respecto al hormigón. Por lo tanto con la ejecución de este proyecto se reduciría sustancialmente la contaminación que produce este tipo de desechos, además de proporcionar un uso adecuado en términos de construcción en la provincia de Santa Elena.

  6. Elena Lasida, 2011, Le goût de l'autre. La crise, une chance pour réinventer le lien, Paris : Albin Michel, 326 p.

    Directory of Open Access Journals (Sweden)

    Igor Martinache

    2011-05-01

    Full Text Available Voici le type d'essai dont la lecture a de quoi laisser quelque peu perplexe. Non seulement parce que l'auteure y alterne fréquemment les registres d'expression (émotionnel ou scientifique, vague ou précis, mais aussi car elle semble de ce fait y courir plusieurs lièvres à la fois. Maître de conférences à l'Institut Catholique de Paris où elle dirige un Master intitulé « Economie solidaire et logique de marché » et est co-responsable de la chaire « Ethique et finance », Elena Lasida propose ...

  7. Breve síntesis histórica y reflexiones acerca de la continuidad étnica, sentido de etnicidad e identidad cultural en la región de Santa Elena, Ecuador

    Directory of Open Access Journals (Sweden)

    Erick López Reyes

    2016-12-01

    Abstract   This paper presents a brief summary of the pre-Hispanic and colonial history of the Santa Elena region, from the first arrival of human groups in the area until the early days of the new Republic of Ecuador. By giving narrative body to a series of data dispersed product of archaeological research, and historical documentaries, made in the region since early last century actually. Based on them then arises a necessary and relevant reflection on issues such as ethnic continuity, ethnicities, culture and identity of the current human groups, descendants of the previous, now inhabit, also raising the importance this has in ongoing processes, and those potential to undertake, for the advancement and local socio-economic development through New tourism or innovation tourism.

  8. La construcción de la imagen heroica a través del discurso periodístico. El caso de la activista peruana María Elena Moyano.

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    Gabriela McEvoy.

    2008-01-01

    Full Text Available This work tries to demonstrate that the social construction of the national hero/heroine as a symbol of courage and resistance generally arises within a period of social, political, and economic crisis. The national hero is a construction that is created in a moment characterized by the loss of public trust and the failure of government leaders to act. The creation of the heroic image functions as a sociopolitical tool. The article suggests that there is a close relationship between the history and the construction of heroic fgures. Using the death of Peruvian activist María Elena Moyano as a concrete example, it demonstrates that journalistic discourse has the ability to create an heroic image around a person who has been given the traditional role that the hero has played in society since Antiquity.

  9. World nuclear power once again in the spotlight. Comments on the 13th Pacfic Basin Nuclear Conference

    International Nuclear Information System (INIS)

    Zang Mingchang; Ruan Keqiang

    2004-01-01

    This paper comments on The 13th Pacific Basin Nuclear Conference held in Shenzhen, China, on October 21/25, 2002 and summarizes some key papers presented in the Conference and viewpoints from their following discussions, which indicates that nuclear power in the world is once again in the spotlight. The Conference shows that in the coming 50 years the roadmap to develop nuclear energy would be divided into two stages: Near-Term Deployment by 2010-2015, some advanced designs were developed for Utilities; Generation IV Program, its overall goal is to identify and develop next-generation nuclear power systems that could be deployed over the next 30 years to help meet the world's energy needs throughout the 21st century. Some visions is the future, such as co-generation of electricity and space heating or desalination, and combination of Generation IV and so-called Hydrogen Economy-the use of hydrogen in vehicle transport to replace petroleum, were presented. As a primary energy source nuclear power is particularly well suited to hydrogen production, offering the almost unique position of large-scale hydrogen production with near-zero emissions. (authors)

  10. Space-variant filtering for correction of wavefront curvature effects in spotlight-mode SAR imagery formed via polar formatting

    Science.gov (United States)

    Jakowatz, Charles V., Jr.; Wahl, Daniel E.; Thompson, Paul A.; Doren, Neall E.

    1997-07-01

    Wavefront curvature defocus effects can occur in spotlight- mode SAR imagery when reconstructed via the well-known polar formatting algorithm under certain scenarios that include imaging at close range, use of very low center frequency, and/or imaging of very large scenes. The range migration algorithm, also known as seismic migration, was developed to accommodate these wavefront curvature effects. However, the along-track upsampling of the phase history data required of the original version of range migration can in certain instances represent a major computational burden. A more recent version of migration processing, the frequency domain replication and downsampling (FReD) algorithm, obviates the need to upsample, and is accordingly more efficient. In this paper we demonstrate that the combination of traditional polar formatting with appropriate space-variant post- filtering for refocus can be as efficient or even more efficient than FReD under some imaging conditions, as demonstrated by the computer-simulated results in this paper. The post-filter can be pre-calculated from a theoretical derivation of the curvature effect. The conclusion is that the new polar formatting with post filtering algorithm should be considered as a viable candidate for a spotight-mode image formation processor when curvature effects are present.

  11. Crossreactive T Cells Spotlight the Germline Rules for [alpha beta] T Cell-Receptor Interactions with MHC Molecules

    Energy Technology Data Exchange (ETDEWEB)

    Dai, Shaodong; Huseby, Eric S.; Rubtsova, Kira; Scott-Browne, James; Crawford, Frances; Macdonald, Whitney A.; Marrack, Philippa; Kappler, John W. (HHMI); (NJMRC)

    2008-10-31

    To test whether highly crossreactive {alpha}{beta} T cell receptors (TCRs) produced during limited negative selection best illustrate evolutionarily conserved interactions between TCR and major histocompatibility complex (MHC) molecules, we solved the structures of three TCRs bound to the same MHC II peptide (IA{sup b}-3K). The TCRs had similar affinities for IA{sup b}-3K but varied from noncrossreactive to extremely crossreactive with other peptides and MHCs. Crossreactivity correlated with a shrinking, increasingly hydrophobic TCR-ligand interface, involving fewer TCR amino acids. A few CDR1 and CDR2 amino acids dominated the most crossreactive TCR interface with MHC, including V{beta}8 48Y and 54E and V{alpha}4 29Y, arranged to impose the familiar diagonal orientation of TCR on MHC. These interactions contribute to MHC binding by other TCRs using related V regions, but not usually so dominantly. These data show that crossreactive TCRs can spotlight the evolutionarily conserved features of TCR-MHC interactions and that these interactions impose the diagonal docking of TCRs on MHC.

  12. Análisis técnico y económico para la reducción de pérdidas técnicas y comerciales en la empresa eléctrica de la peninsula de Santa Elena ca (emepe)

    OpenAIRE

    Estrada Mendez, Jorga Armando; Nieto Pasquel, Ronny Elias; Rivera Paredes, Jorge Hernando; Salcedo Guerrero, Adolfo

    2009-01-01

    En el siguiente proyecto de tesis se presenta un análisis técnico económico de la empresa eléctrica de la península de Santa Elena (EMEPE), para la reducción de pérdidas técnicas y comerciales. Se procederá a calcular las pérdidas técnicas y pérdidas comerciales del año 2004, para ello se obtendrá la información correspondiente en la empresa eléctrica de la península de Santa Elena y además se realizaran levantamientos eléctricos del sistema de distribución para realizar los cálculos pert...

  13. Lack of interest in physical activity - individual and environmental attributes in adults across Europe: The SPOTLIGHT project.

    Science.gov (United States)

    Carraça, Eliana V; Mackenbach, Joreintje D; Lakerveld, Jeroen; Rutter, Harry; Oppert, Jean-Michel; De Bourdeaudhuij, Ilse; Compernolle, Sofie; Roda, Célina; Bardos, Helga; Teixeira, Pedro J

    2018-02-21

    A considerable proportion of European adults report little or no interest in physical activity. Identifying individual-level and environmental-level characteristics of these individuals can help designing effective interventions and policies to promote physical activity. This cross-sectional study additionally explored associations between level of interest and physical activity, after controlling for other individual and environmental variables. Measures of objective and perceived features of the physical environment of residence, self-reported physical activity and other lifestyle behaviors, barriers towards physical activity, general health, and demographics were obtained from 5205 European adults participating in the 2014 online SPOTLIGHT survey. t-Tests, chi-square tests, and generalized estimating equations with negative binomial log-link function were conducted. Adults not interested in physical activity reported a higher BMI and a lower self-rated health, were less educated, and to a smaller extent female and less frequently employed. They were more prone to have less healthy eating habits, and to perceive more barriers towards physical activity. Only minor differences were observed in environmental attributes: the non-interested were slightly more likely to live in neighborhoods objectively characterized as less aesthetic and containing more destinations, and perceived as less functional, safe, and aesthetic. Even after controlling for other individual and environmental factors, interest in physical activity remained a significant correlate of physical activity, supporting the importance of this association. This study is among the first to describe characteristics of individuals with reduced interest in physical activity, suggesting that (lack of) interest is a robust correlate of physical activity in several personal and environmental conditions. Copyright © 2018. Published by Elsevier Inc.

  14. Efecto de la vinculación con la colectividad en el beneficio económico de las asoociaciones de producción. Caso de estudio: Paja Toquilla en la Comuna Barcelona, Parroquia Manglaralto. Provincia de Santa Elena, año 2015

    Directory of Open Access Journals (Sweden)

    Juan C Carriel

    2015-12-01

    Abstract The State University of Santa Elena Península and Accounting and Auditing Career; in the framework of a process of linking with the community, allows the interaction of the institution with the society, through the design and implementation of projects that contribute to the development, constituting itself as a benefit in the advancement of knowledge, training of human talent, the exchange of ideas and the solution of specific problems. In Ecuador, artisans occupy an important place, as regards to economic development is further directed to have laws backup as the law of defense of the artisan, the law to promote artisanal production code, whose common goal It is to enable economic growth of artisans and contribute to meeting the objective 1, 3, 10 of the National Plan for Good Living. So the implementation of links with the community was framed for artisans who are engaged in the production of straw shawl in the commune Barcelona, Manglaralto parish, canton Santa Elena, Province of Santa Elena, in order to contribute to the socioeconomic improvement associations union through the exchange of knowledge and generate from its production processes; accounting, where the level of profitability of the activity is known, and also have a reliable database for timely decision-making; allowing the sustainable development of the producer.

  15. [The intervention of Dr Francisco Díaz in the inquisitorial process against Elena/o de Cespedes, a transsexual surgeon found guilty by the Inquistion in Toledo in 1587].

    Science.gov (United States)

    Maganto Pavón, Emilio

    2007-10-01

    To make known, comprehensively, an almost unknown episode in the life of Dr. Francisco Diaz (1527-1590), surgeon of the king Philip II, and author of the first urology treaty in the history of medicine. To our knowledge, to date there were few references about the participation that, as an expert, Francisco Diaz had to have in the inquisitorial process against Elena de Cespedes, a presumed hermaphrodite accused by the Inquisition because being a woman married another one pretending to be a man. The trial was carried out in Toledo in 1587 and had great impact in that time, because the accused, dressing with male clothes and usurping the prerogatives of a man, had gotten by fraud titles and favours which were forbidden for women, the title of surgeon among them. Except for the reference by Folch Jou and Burshatin, both short and incomplete, no other author or biographer of the famous surgeon had cited this episode of his life, which to our judgment could mean a great damage to his reputation. We reviewed the works by the two aforementioned authors, all the works and biographies about Dr. Francisco Diaz that we could found, and microfilmed and transcript the whole bundle 234, expedient 24, from the section Inquisition at the National Historical Archive in Madrid, corresponding to Elena de Cespedes (alias Eleno) (> 500 pages) to obtain the greatest amount of data about the accused and the performance of Dr. Francisco Diaz. Francisco Diaz was requested, as an expert, by the Vicar of Madrid to perform the examination of the genitourinary organs to give or not marriage license to that woman saying she was a man. In his report in the year 1586, surprisingly the urologist declared that the petitioner was a man. As it would be demonstrated during the trial, the accused, who alleged being hermaphrodite in her defense, had been able to deceive the expert with her tricks altering her genital morphology. Thanks to her surgical knowledge she had mutilated herself surgically

  16. Elaboración de hormigones que minimicen el impacto al ambiente, empleando neumáticos usados de vehículos livianos y pesados, en la provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Armando Saltos

    2015-10-01

    Waste from rubbers tires are considered to be an environmental and sanitary risk worldwide. As an example in Ecuador, every year nearly 2.4 million rubber tires of various types are discarded as trash, which is equivalent to 55000 tons, according to the Proactive Corporation for Investment Promotion (INVEC. A small porcentage of the waste, are reused to be re-rubberized. But the majority is incinerate or deposited in dumping grounds open to the environment, which is a huge risk to the environment and the health of individuals. The project seeks to create a design of concrete including particles of rubber from discarded tires. The tires will undergo a rigorous selection process, a controlled threading process, and a fabrication according to the specifications of the international standards of concrete of the American Concrete Institute (ACI and the Construction Ecuatorian Standards (NEC, and based on these specifications, the goal is to obtain an acceptable concrete apt to be used in low traffic streets, sidewalks, pedestrian zones, and other concrete structures, minimizing the environmental impact to the misuse of tires in the province of Santa Elena.

  17. Evaluación de Dosis de Nitrógeno en combinación con Vitazyme en el rendimiento de la Sandía, en Sinchal, Provincia de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Néstor Orrala B

    2015-10-01

    Full Text Available La investigación tuvo como objetivo evaluar la interacción del bioestimulante Vitazyme en combinación con varias dosis de fertilizantes nitrogenados, en la productividad del híbrido Doña Flor, sandía tipo Charleston Grey, en Sinchal Santa Elena. Diseño utilizado bloques completamente al azar con 8 tratamientos y 4 repeticiones. Cada unidad experimental conformada por 45 plantas. Resultados sometidos al análisis de la varianza y las medias de los tratamientos, comparadas según Prueba de Rango Múltiple de Duncan al 5 %. Variables evaluadas: longitud de guía a los 40 y 60 días después del trasplante, número de flores femeninas, número de frutos comerciales por planta, longitud, diámetro, peso del fruto y rendimiento por hectárea, más análisis económico. El nitrógeno más una base PK, así como también el nitrógeno más una base PK más el bioestimulante Vitazyme aumenta el número de frutos comerciales por planta, repercutiendo en el rendimiento y la rentabilidad, sobresaliendo el tratamiento N150P80K200 + Vitazyme que alcanzó 117,08 toneladas por hectárea.

  18. Incidencia de la gestión de marketing y procedimientos de injerencia contable en las empresas privadas de la Provincia de Santa Elena, año 2014-2015

    Directory of Open Access Journals (Sweden)

    Libi Caamaño

    2015-12-01

    Abstract Accounting control systems allow the company to know about the economic situation and make decisions; secondly marketing management facilitates compliance with business objectives, to capture the attention of the target market, encouraging customers to purchase action, and current customer loyalty, these two components enable companies to take advantage of any kind environmental opportunities to know the current situation, so the negative impact is minimized. This study aims to assess the impact of accounting control systems and marketing in the administration of private enterprises in the province of Santa Elena, the process of gathering information was aimed at obtaining information from the company managers, financial personnel and public relations in the absence of marketing department in the majority of companies. It was evident that no innovative strategic actions in companies, that will generate knowledge effectively brand in the target market, however, the accounting systems used are appropriate, whether made mostly traditional way, not technological tools are used. The importance of implementing accounting control systems that improve the administrative management of private enterprise in the province, as well as marketing efforts to improve compliance with business objectives entities was determined.

  19. Interrelación de la productividad en el sector artesanal y la vinculación con la colectividad: red de artesanos de la parroquia Atahualpa, provincia de Santa Elena, año 2015

    Directory of Open Access Journals (Sweden)

    Germán Arriaga Baidal

    2016-12-01

      One of the areas of the work of the universities is their relationship with the community, which must generate a productivity interrelationship in both parts. Thus, she connects with teaching and invigorates it. The Santa Elena Peninsula State University and the Department of Linkage through the Accounting and Auditing Career develop this process, with the design and execution of projects that contribute to the development and generate alternative solutions to the problems of the communities. It is currently debated, if the link is understood as the moment in which the university relates to external social actors, without considering the participation of students and teachers in that process, and its effects, both in the community and in University teaching. In the pursuit of productivity, each linking teacher prepares and executes a series of actions, in order to have a positive impact on the student's and the trainee's training process, and their participation in linking projects, a valuable moment that is also considered as an indicator Of productivity - quality, in the field of teaching.

  20. INCIDENCIA DE UN PLAN DE DESARROLLO TURÍSTICO EN LA SOSTENIBILIDAD Y COMPETITIVIDAD DE LA COMUNA EL REAL, PARROQUIA CHANDUY, CANTÓN SANTA ELENA, PROVINCIA DE SANTA ELENA” AÑO 2015

    Directory of Open Access Journals (Sweden)

    Mercedes Freire

    2016-12-01

    Full Text Available La presente investigación tiene como objetivo determinar la incidencia de un plan de desarrollo turístico en la sostenibilidad y competitividad de la Comuna El Real, de la Provincia de Santa Elena, en el cual se debe aprovechar el recurso natural y cultural que tiene la comuna, donde se propicie la generación de una dinámica auténtica para la captación del turismo rural con la lógica y generación de un desarrollo desde adentro, contribuyendo de este modo al buen vivir de la comuna. Entre los problemas que se evidenciaron se encuentra la sostenibilidad, no cuenta con un desarrollo ambiental, económico, y social, proyectos de emprendimiento, se plantea estrategias sostenibles y competitivas desde la perspectiva del turismo rural. Para la elaboración de este trabajo se utilizó la metodología basada en investigación cuantitativa y cualitativa. Se describió las características generales de la problemática existente, permitiendo elaborar una diagnostico situacional de tipo integral, con la implementación de estrategias como son, los convenios con las instituciones del estado, cursos de capacitaciones a los comuneros para que puedan realizar una eficiente administración comunal, buen trabajo en equipo, ejecución de programas y proyectos, participación oportuna de los habitantes para el logro de un crecimiento permanente para la comuna, sus organizaciones y asociaciones ubicadas dentro de su territorio.  Palabras clave: recursos turísticos, recursos culturales, desarrollo sostenible, estrategias competitivas Abstract This research aims to determine the incidence of a plan of tourist in the sustainable environmental, economic and social development, through an internal of the Commune diagnosis the Real, of the Province of Santa Elena, which should benefit from the natural and cultural resource that has the commune, where is conducive to the generation of a real dynamic for the acquisition of rural tourism with the logical

  1. Evaluación de ideas irracionales en los postulantes de diversas carreras que oferta la Universidad Estatal Península de Santa Elena en el segundo semestre del periodo 2013 – 2014

    Directory of Open Access Journals (Sweden)

    Rocío Ponce

    2015-10-01

    Abstract This research conducted at the Santa Elena Peninsula University evaluates the belief systems that have been increasing in the social and technological careers in the sense of values is important and essential, applicants offered eight careers such as Accountants, nursing, Tourism, IT, civil engineering, petroleum engineering, Administration and Marine Biology held belief systems can affect school performance and expectations with entering the higher education system. Ten areas of the TCI Test Irrational ideas are revised and abbreviated version Need for acceptance test, the presence of self expectations, guilt, frustration intolerance, levels of worry and anxiety, emotional irresponsibility, problem avoidance, dependence are evaluated , helplessness and perfectionism. This is a first test survey on belief system based on other higher studies in similar populations and the results show similar levels of belief systems among students majoring in question and then a comparative study with a population of the School of Psychology that is graduating. Statistical analysis of the data would show the areas where from the Student Welfare Department should work to change certain ways of thinking that do not allow the normal development of academic activities. An analysis of the percentages for items of irrationality in the areas further ago. In order to meet our student population and to anticipate better performance in their step and their permanence in the institution of higher education. Were evaluated without regard to the whole population has been called because that way you can check more accurately the data in question. Is proposed on the basis of these data to initiate a program of psychological intervention to strengthen comprehensively changes belief systems and values that will promote technological change in line with the social area and rescue principles and ways of thinking from the region and to be based on good living. The projection having on

  2. Estudio sobre las Competencias Demandadas por las Empresas, para la Inserción Laboral de los Profesionales en la Provincia de Santa Elena año 2013.

    Directory of Open Access Journals (Sweden)

    Jairo Cedeño

    2015-10-01

    Full Text Available La presente investigación tiene como objetivo determinar las competencias demandadas por las empresas tanto públicas y privadas de la provincia y analiza la inserción laboral de los profesionales. Hoy en día las empresas crecen, se expanden y esa es la oportunidad para que las universidades oferten estudiantes con habilidades, destrezas y conocimientos de acuerdo a lo que las empresas demandan. Por ello la importancia de este estudio el cual determinó las competencias que demandan las empresas para poder insertar a nuestros profesionales en las diversas áreas laborales, para que se puedan explotar esas capacidades adquiridas en la universidad. Se realizó un estudio cuantitativo el cual determinó que en las empresas de la provincia de Santa Elena se encuentran laborando jóvenes entre las edades de 25 a 35 años. En su proceso de reclutamiento de personal están considerando como primera instancia, experiencia laboral, seguido formación profesional, título académico, cursos de actualización entre otros. Entre las principales actividades que realizan los profesionales corresponde a las áreas contables, gestión del talento humano, evaluación y formulación de proyectos, presupuesto y compras públicas. Se determinó además entre las principales destrezas que deben de tenerlos profesionales al momento de incorporar en el ámbito laboral es; trabajo en equipo, liderazgo, ética profesional y conocimiento en el idioma Ingles. La provincia se destaca por su turismo, relaciones humanas, y conocimientos administrativos.

  3. Sri Lanka. Spotlight.

    Science.gov (United States)

    Hoque, M N

    1985-01-01

    Sri Lanka, an island country off the southeastern coast of India, populated by an estimated 16.1 million inhabitants, was one of the 1st developing countries to adopt a population policy aimed at reducing population growth and redistributing the population more equitably throughout the country. Population density is high. There are 636 persons/square mile, and 2/3 of the population lives in the southwestern and central regions of the country. Government redistribution policies seek to increase internal migration flows to the drier and less populated areas. The country's birth rate was 27 in 1982, the death rate was 6 in 1981, and the infant mortality rate was 34.4 in 1980. The rate of natural increase in 1982 was 2.1%, and the population growth rate declined from 2.5% prior to 1970 to 1.7% in 1980. The total fertility rate declined between 1963-74 from 5.0-3.4 and then increased to 3.7 in recent years. Given the age structure of the population, the population is expected to continue growing at a high rate in the coming years; however, the age at marriage is increasing and the proportion of young married women in the population is declining, and these trends will have an impact on population growth. These trends are due in part to increased educational and employment opportunities for women. The delay in marriage may also be linked to the dowry system. Given the high rate of poverty, it is difficult for parents to accummulate sufficient resources to provide dowries for their daughters. Sri lanka's economy is predominantly agricultural, with only 15% of the gross national product derived from manufacturing. Approximately 22% of thepopulation lives in urban areas. In 1981 exports totaled US$1.1 billion, and major export items were tea and rubber. In the same year, imports totaled US$1.8 billion and consisted primarily of food, petroleum, and fertilizers. The per capita gross national product was US$320 in 1982. Sri Lanka receives considerable foreign aid, and the country's family planning program receives substantial outside support.

  4. Molecules in the Spotlight

    Energy Technology Data Exchange (ETDEWEB)

    Cryan, James

    2010-01-26

    SLAC has just unveiled the world's first X-ray laser, the LCLS. This machine produces pulses of X-rays that are ten billion times brighter than those from conventional sources. One of the goals of this machine is to make movies of chemical reactions, including reactions necessary for life and reactions that might power new energy technologies. This public lecture will show the first results from the LCLS. As a first target, we have chosen nitrogen gas, the main component of the air we breathe. Using the unprecedented power of the LCLS X-rays as a blasting torch, we have created new forms of this molecule and with unique electronic arrangements. Please share with us the first insights from this new technology.

  5. Spotlight: Health Newsmakers

    Science.gov (United States)

    ... NIH). "Ensuring all Americans have health care is integral to the mission of HHS and the well– ... said, "Ensuring all Americans have health care is integral to the mission of HHS and the well ...

  6. Spotlight on VET Denmark

    Science.gov (United States)

    Cedefop - European Centre for the Development of Vocational Training, 2012

    2012-01-01

    This paper presents data on the vocational education and training (VET) in Denmark. VET plays a key role in the Danish strategy for lifelong learning and meeting the challenges of globalisation and technological change. The Danish education and training system comprises a mainstream system providing qualifications at all levels, from compulsory…

  7. Physics in the Spotlight

    Science.gov (United States)

    2000-10-01

    CERN, ESA and ESO Put Physics On Stage [1] Summary Can you imagine how much physics is in a simple match of ping-pong, in throwing a boomerang, or in a musical concert? Physics is all around us and governs our lives. The World-Wide Web and mobile communication are only two examples of technologies that have rapidly found their way from science into the everyday life. [Go to Physics On Stage Website at CERN] But who is going to maintain these technologies and develop new ones in the future? Probably not young Europeans, as recent surveys show a frightening decline of interest in physics and technology among Europe's citizens, especially schoolchildren. Fewer and fewer young people enrol in physics courses at university. The project "Physics on Stage" tackles this problem head on. An international festival of 400 physics educators from 22 European countries [2] gather at CERN in Geneva from 6 to 10 November to show how fascinating and entertaining physics can be . In a week-long event innovative methods of teaching physics and demonstrations of the fun that lies in physics are presented in a fair, in 10 spectacular performances, and presentations. Workshops on 14 key themes will give the delegates - teachers, professors, artists and other physics educators - the chance to discuss and come up with solutions for the worrying situation of disenchantment with Science in Europe. The European Science and Technology Week 2000 "Physics on Stage" is a joint project organised by the European Organisation for Nuclear Research (CERN) , the European Space Agency (ESA) and the European Southern Observatory (ESO) , Europe's leading physics research organisations. This is the first time that these three organisations have worked together in such close collaboration to catalyse a change in attitude towards science and technology education. Physics on Stage is funded in part by the European Commission and happens as an event in the European Science and Technology Week 2000, an initiative of the EC to raise public awareness of science and technology. Other partners are the European Physical Society (EPS) and the European Association for Astronomy Education (EAAE). European Commissioner Busquin to Visit Physics On Stage On Thursday, November 9, Philippe Busquin , Commissioner for Research, European Commission, Prof. Luciano Maiani , Director-General of CERN, Antonio Rodota , Director-General of ESA, Dr. Catherine Cesarsky , Director-General of ESO, and Dr. Achilleas Mitsos , Director-General of the Research DG in the European Commission, will participate in the activities of the Physics on Stage Festival. On this occasion, Commissioner Busquin will address conference delegates and the Media on the importance of Science and of innovative science and technology education. The Festival Each of the more than 400 delegates of the festival has been selected during the course of the year by committees in each of the 22 countries for outstanding projects promoting science. For example, a group of Irish physics teachers and their students will give a concert on instruments made exclusively of plumbing material, explaining the physics of sound at the same time. A professional theatre company from Switzerland stages a play on antimatter. Or two young Germans invite spectators to their interactive physics show where they juggle, eat fire and perform stunning physics experiments on stage. The colourful centrepiece of this week is the Physics Fair. Every country has its own stands where delegates show their projects, programmes or experiments and gain inspiration from the exhibits from other countries. Physics on Stage is a unique event. Nothing like it has ever happened in terms of international exchange, international collaboration and state of the art science and technology education methods. The Nobel prizewinners of 2030 are at school today. What ideas can Europe's teachers put forward to boost their interest in science? An invitation to the media We invite journalists to take part in this both politically and visually interesting event. We expect many useful results from this exchange of experience, there will a large choice of potential interview partners and of course uncountable images and impressions. Please fill in the form below and fax it back to CERN under +41 22 7850247. Go to the Webpage http://www.cern.ch/pos to find out all about Physics on Stage Festival at CERN. The main "Physics on Stage" web address is: http://www.estec.esa.nl/outreach/pos There is also a Physics On Stage webpage at ESO Notes [1] This is a joint Press Release by the European Organization for Nuclear Research (CERN) , the European Space Agency (ESA) and the European Southern Observatory (ESO). [2] The 22 countries are the member countries of at least one of the participating organisations or the European Union: Austria, Belgium, Bulgaria, the Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Luxembourg, the Netherlands, Norway, Poland, Portugal, the Slovak Republic, Spain, Sweden, Switzerland, United Kingdom.

  8. SPOTLIGHTING ENGLISH PHRASAL VERBS

    Directory of Open Access Journals (Sweden)

    Éva Kovács

    2014-03-01

    Full Text Available Phrasal verbs or multi-word verbs, such as call off, go into and run up against, etc. represent a very interesting and challenging aspect of the English language. In ELT there is a widespread view that familiarity with a wide range of phrasal verbs and the ability to use them appropriately in context are among the distinguishing marks of a native-like command of English. However, it is also generally recognised that these verb+particle combinations pose special difficulties for both learners and teachers of English partly because there are so many of them, partly because they have special semantic, syntactic and stylistic properties. Besides, quite many of them can be used as nouns, e.g. a hideaway, a stowaway and a write-off, etc. and adjectives, e.g. a broken-down car and a knockdown price, etc. What is more, again quite many of them have a single word equivalent of Romance origin, which, however, often differs from them in terms of style, collocation and meaning, e.g. blow up ~ explode, do away with ~ eliminate and put out ~ extinguish, etc. Furthermore, it is a misconception that phrasal verbs are mainly used in informal style and in spoken English. In fact, they can be found in many styles of writing, ranging from highly formal texts to slang, e.g. call forth vs. gobble up, etc. This paper sets out to explore the unique and complex nature of English verb+particle constructions in order to make them a more manageable part of the vocabulary of English.

  9. Spotlight on Spelling.

    Science.gov (United States)

    Hardin County Board of Education, Elizabethtown, KY.

    Word lists and class activities are suggested for improving the spelling of elementary school students. The word lists contain rhyming words, antonyms, synonyms, homonyms, 100 spelling demons, look-alike words that are easily confused, and content area words (for geography, mathematics, science, sports, music, social studies). The suggested…

  10. Spotlight on the media

    CERN Multimedia

    2007-01-01

    Do you want to know more about how the media works, how to deal with journalists? How to maximise opportunity and minimise threat? Then please join us on 22 November. This session will cover how to work effectively with the media, including print, radio and TV. You’ll get an insight into how journalists and news rooms operate. You’ll learn to recognise both soft balls and traps - and develop the techniques for dealing with them. The challenges of explaining CERN to any media outlet will be dealt with too. This interactive presentation, given by Jessica Pryce-Jones, Managing Director of the consultancy firm iOpener Ltd, and Nisha Pillai, news anchor for BBC World, will be illustrated with various case studies. How to deal with the media: maximising opportunity and minimising threat Thursday 22 November, from 4.30 pm, Main Auditorium, Bldg. 500 Coffee break before the event at 4.00 pm

  11. Spotlight on VET: Ireland

    Science.gov (United States)

    Cedefop - European Centre for the Development of Vocational Training, 2013

    2013-01-01

    This paper provides an overview of VET (vocational education and training) in Ireland. In Ireland, the main providers of VET are the national Training and Employment Authority (FAS--a non-commercial semi-State body, part of the public sector) and vocational education committees (VECs--public sector bodies at county level responsible for vocational…

  12. Costa Rica. Spotlight.

    Science.gov (United States)

    Haub, C; Adams, J

    1985-05-01

    Costa Rica's demographic and economic characteristics are highlighted. Costa Rica's demographic situation is unique in certain respects. Between the late 1950s and the late 1970s, the total fertility rate declined from about 7 to 4 and then stabilized instead of continuing to decline to 2 as expected. This is especially surprising since the level of contraceptive use is similar to that of most European countries. Approximately 2/3 of all couples practice contraception. It is possible that the rate will slowly decline to the expected level, but a delayed decline will ultimately produce a much larger population than initially expected. The demographic situation in Costa Rica is being carefully monitored for insights which might be useful in predicting future fertility patterns in other developing countries. The government of Costa Rica recognizes that family planning is a necessary component of maternal and child health care; however, most family planning services are provided by private organizations. In 1982, population size was 2.6 million, the crude birth rate was 30.7, the crude death rate was 3.9, infant mortality was 19.3, and the rate of natural increase was 2.7%. The population is predominantly Spanish, and the indigenous population totals only 20,000. 48% of the population is urban. Costa Rica has a relatively stable deomocratic government. It relationshiops with other countries are generally peaceful, but tensions between Nicaragua and Costa Rica are increasing. The country's economic situation deteriorated in recent years due primarily to a decline in the price of coffee, the country's principle export commodity. The trade deficit increased markedly, unemployment increased, and income fell sharply. The economic slowdown is now showing signs of a reversal. In 1983 exports, consisting primarily of coffee, bananas, beef, sugar, cane and cacao, totalled US$871 million, and imports, consisting mainly of manufactured goods and equipment, chemicals, fuel, food, and fertilizer, amounted to US$870 million. In 1983 the per capita gross national product was US$1020.

  13. Spotlight on Peru.

    Science.gov (United States)

    1997-01-01

    Lima's population grew from 1 million to 7 million during 1969-89, almost entirely due to rural-urban immigration. Other urban areas such as Iquitos experienced similar growth over the period. National, regional, and municipal governments have been working to restore civil order in the country and to bring basic health, sanitation, and education programs to the population. However, language, attitudinal, and cultural differences impede progress in this diverse and changing country. Peru's young population of median age 21 years presents a challenge to the development and implementation of effective reproductive health care programs for the country. Pathfinder's work in Peru is helped by current President Alberto Fujimori's strong and active support for family planning. In the face of strong opposition from the Roman Catholic Church, President Fujimori has held onto his conviction and commitment to reduce levels of maternal morbidity and mortality in Peru by increasing the accessibility of family planning programs. Pathfinder's work in Peru with the US Agency for International Development (USAID) includes the 5-year program Project 2000 designed to improve maternal and child health in 12 priority regions of the country. Pathfinder is also working with USAID to link family planning to postpartum services in 30 public hospitals throughout the country. New programs will be launched with contributions from individuals and foundations.

  14. Obesity-related behaviours and BMI in five urban regions across Europe: sampling design and results from the SPOTLIGHT cross-sectional survey.

    Science.gov (United States)

    Lakerveld, Jeroen; Ben Rebah, Maher; Mackenbach, Joreintje D; Charreire, Hélène; Compernolle, Sofie; Glonti, Ketevan; Bardos, Helga; Rutter, Harry; De Bourdeaudhuij, Ilse; Brug, Johannes; Oppert, Jean-Michel

    2015-10-27

    To describe the design, methods and first results of a survey on obesity-related behaviours and body mass index (BMI) in adults living in neighbourhoods from five urban regions across Europe. A cross-sectional observational study in the framework of an European Union-funded project on obesogenic environments (SPOTLIGHT). 60 urban neighbourhoods (12 per country) were randomly selected in large urban zones in Belgium, France, Hungary, the Netherlands and the UK, based on high or low values for median household income (socioeconomic status, SES) and residential area density. A total of 6037 adults (mean age 52 years, 56% female) participated in the online survey. Self-reported physical activity, sedentary behaviours, dietary habits and BMI. Other measures included general health; barriers and motivations for a healthy lifestyle, perceived social and physical environmental characteristics; the availability of transport modes and their use to specific destinations; self-defined neighbourhood boundaries and items related to residential selection. Across five countries, residents from low-SES neighbourhoods ate less fruit and vegetables, drank more sugary drinks and had a consistently higher BMI. SES differences in sedentary behaviours were observed in France, with residents from higher SES neighbourhoods reporting to sit more. Residents from low-density neighbourhoods were less physically active than those from high-density neighbourhoods; during leisure time and (most pronounced) for transport (except for Belgium). BMI differences by residential density were inconsistent across all countries. The SPOTLIGHT survey provides an original approach for investigating relations between environmental characteristics, obesity-related behaviours and obesity in Europe. First descriptive results indicate considerable differences in health behaviours and BMI between countries and neighbourhood types. Published by the BMJ Publishing Group Limited. For permission to use (where not

  15. Evaluación estructural y rehabilitación sísmica del Hotel Samarina de propiedad de la Universidad Península de Santa Elena, para la creación de un modelo disipador de energía.

    Directory of Open Access Journals (Sweden)

    Armando Saltos

    2015-12-01

    Full Text Available El Hotel Samarina está ubicado frente al mar, en la cota +12 m s.n.m., en el cantón La Libertad, Provincia de Santa Elena. Fue construido al final de la década de los 50. El hotel Samarina terminado en un 70%, se compone de planta baja y tres pisos altos y estructuras de hormigón armado. La superficie total del mencionado hotel es de 2638 m2. Actualmente, se conoce que en el Ecuador y principalmente en la Provincia de Santa Elena, presenta una alta sismicidad por estar ubicada cercana a la zona de subducción de la placa de nazca y la placa sudamericana. A través de una evaluación y diagnóstico estructural, conforme a las normas ecuatorianas NEC 2011 o códigos uniformes de edificación UBC 97 la actual edificación no cumple el diseño sismoresistente, y de acuerdo al conocimiento actual se elaboró un diseño moderno donde se mejoró su nivel de desempeño o comportamiento sismo resistente ante la acción de un sismo moderado, y con la aplicación de un software libre denominado ETAB's se implementó un modelo con sistema de reforzamiento, compuesto de disipadores de energía colocados en las caras laterales y reforzamiento de columnas en los cuatro niveles que componen el edificio.   ABSTRACT The Samarina Hotel is located close to the sea, at 12 m s.n.m., at La Libertad, Province of Santa Elena. It was constructed at the end of the decade of the 50. The hotel has a ground floor and three high floors and it has reinforced concrete structures with surface of 26382. In the Ecuador and principally at Province of Santa Elena, has a high seismicity conditions because of it are located near to the zone of subduction of the Nazca South plates. An evaluation and structural diagnosis was performed, according to NEC 2011 proceeding, and also with the uniform codes of building UBC97. It is important to indicate that the actual building does not fulfill the design seismic resistant requirements. To improve the level resistant earthquake was

  16. Earthquake-Induced Building Damage Detection with Post-Event Sub-Meter VHR TerraSAR-X Staring Spotlight Imagery

    Directory of Open Access Journals (Sweden)

    Lixia Gong

    2016-10-01

    Full Text Available Compared with optical sensors, Synthetic Aperture Radar (SAR can provide important damage information due to its ability to map areas affected by earthquakes independently from weather conditions and solar illumination. In 2013, a new TerraSAR-X mode named staring spotlight (ST, whose azimuth resolution was improved to 0.24 m, was introduced for various applications. This data source made it possible to extract detailed information from individual buildings. In this paper, we present a new concept for individual building damage assessment using a post-event sub-meter very high resolution (VHR SAR image and a building footprint map. With the building footprint map, the original footprints of buildings can be located in the SAR image. Based on the building imaging analysis of a building in the SAR image, the features in the building footprint can be extracted to identify standing and collapsed buildings. Three machine learning classifiers, including random forest (RF, support vector machine (SVM and K-nearest neighbor (K-NN, are used in the experiments. The results show that the proposed method can obtain good overall accuracy, which is above 80% with the three classifiers. The efficiency of the proposed method is demonstrated based on samples of buildings using descending and ascending sub-meter VHR ST images, which were all acquired from the same area in old Beichuan County, China.

  17. Application of the EGM Method to a LED-Based Spotlight: A Constrained Pseudo-Optimization Design Process Based on the Analysis of the Local Entropy Generation Maps

    Directory of Open Access Journals (Sweden)

    Enrico Sciubba

    2011-06-01

    Full Text Available In this paper, the entropy generation minimization (EGM method is applied to an industrial heat transfer problem: the forced convective cooling of a LED-based spotlight. The design specification calls for eighteen diodes arranged on a circular copper plate of 35 mm diameter. Every diode dissipates 3 W and the maximum allowedtemperature of the plate is 80 °C. The cooling relies on the forced convection driven by a jet of air impinging on the plate. An initial complex geometry of plate fins is presented and analyzed with a commercial CFD code that computes the entropy generation rate. A pseudo-optimization process is carried out via a successive series of design modifications based on a careful analysis of the entropy generation maps. One of the advantages of the EGM method is that the rationale behind each step of the design process can be justified on a physical basis. It is found that the best performance is attained when the fins are periodically spaced in the radial direction.

  18. Proidi tsherez "igolnoje ushko" / Elena Rudi

    Index Scriptorium Estoniae

    Rudi, Elena

    2007-01-01

    Tallinnas avati pidulikult taastatud Trepi tänav Nõelasilma väravaga. Taastatud väravaehitist ilmestab vanast väravast säilinud barokkstiilis raidreljeef. Taastamisprojekti autor on restauraator Marek Lill

  19. Mejoramiento de las capacidades lingüísticas en el idioma inglés a través de la modalidad Blended Learning para el personal docente de la universidad estatal península de santa elena en el período académico 2015 - 2016

    Directory of Open Access Journals (Sweden)

    Xavier Almeida

    2015-10-01

    This article is the result of teamwork by the Research Team of The English Teaching Career at Peninsula of Santa Elena State University  “U P S E ”.  The basis of this publication is the previous research done by the English career in the years 2012 - 2013.  From this work important data has been selected exclusively from the part in which educators manifested their interest in improving their English competence with the Blended Learning System which offers flexible schedules and classes. There is also an approved project to be executed in the year 2015-2016.  Using these two previous papers as reference this article has been written.

  20. High resolution deformation maps of Volcán de Colima, Mexico, derived from a year-long TerraSAR-X Spotlight time series

    Science.gov (United States)

    Salzer, Jacqueline; Nikkhoo, Mehdi; Walter, Thomas R.

    2015-04-01

    Volcán de Colima is a steep sloped explosive stratovolcano located in southern Central Mexico, and one of the most active volcanoes in North America. Major recent historical eruptions occured in 1818 (VEI 4) and 1913 (VEI 5), which removed several hundred meters from the summit of the volcanic edifice [1], and point towards the activity being marked by 100-year cycles which terminate in a large Plinian eruption. Also, five large flank collapse events have been identified during the Holocene [2]. Since the beginning of the most recent eruptiove period in 1998, the type of activity has been varying between predominantly explosive, dome building and dome collapse. Between 2007 and 2011, the activity at Colima was characterized by dome extrusion. The volcano then entered a period of low activity, which lasted until January 2013, when a series of explosions took place which initiated a new, still ongoing period of dome growth. The historical eruption of 1913, as well as the renewal of the activity in 2013, were both preceeded by longer periods of low activity, and only very limited short term precursors. The year 2012 at Volcán de Colima is therefore a good example to study volcanic activity in periods of quiescence, but leading up to an eruption. Furthermore, the possibility of a larger event in the future make it a particularly important volcano to study. We have acquired TerraSAR-X data in spotlight mode for ascending and descending tracks over Colima, obtaining a high spatial resolution of up to 2 m, and a temporal resolution of up to 11 days. Here we present the time series of the dome deformation between February and December 2012. We generated interferograms using an updated version of DORIS, accounting for the doppler variation in along track direction [3] and subsequently analysed the time series of the deformation pattern with the small baseline - persistent scatterer (PS) approach implemented in the StaMPS software. We removed the topographically correlated

  1. CURE Scholar Spotlight - Dr. Brady

    Science.gov (United States)

    Donita C. Brady, a Research Associate Senior at the Department of Pharmacology and Cancer Biology at Duke University, is investigating the role that copper plays in cell growth and tumor biology. Inspired by her mentor Christopher Counter, a cancer biologist, and Dennis Thiele, a copper biologist, at Duke University, Brady has a unique interest in the way copper interacts with protein pathways, such as the BRAF (a human gene that directs cell growth)-MEK-ERK pathway, which is a major target for targeted cancer therapies because the BRAF gene is mutated 60% of the time in melanoma.

  2. Spotlight on medicinal chemistry education.

    Science.gov (United States)

    Pitman, Simone; Xu, Yao-Zhong; Taylor, Peter; Turner, Nicholas; Coaker, Hannah; Crews, Kasumi

    2014-05-01

    The field of medicinal chemistry is constantly evolving and it is important for medicinal chemists to develop the skills and knowledge required to succeed and contribute to the advancement of the field. Future Medicinal Chemistry spoke with Simone Pitman (SP), Yao-Zhong Xu (YX), Peter Taylor (PT) and Nick Turner (NT) from The Open University (OU), which offers an MSc in Medicinal Chemistry. In the interview, they discuss the MSc course content, online teaching, the future of medicinal chemistry education and The OU's work towards promoting widening participation. SP is a Qualifications Manager in the Science Faculty at The OU. She joined The OU in 1993 and since 1998 has been involved in the Postgraduate Medicinal Chemistry provision at The OU. YX is a Senior Lecturer in Bioorganic Chemistry at The OU. He has been with The OU from 2001, teaching undergraduate courses of all years and chairing the master's course on medicinal chemistry. PT is a Professor of Organic Chemistry at The OU and has been involved with the production and presentation of The OU courses in Science and across the university for over 30 years, including medicinal chemistry modules at postgraduate level. NT is a Lecturer in Analytical Science at The OU since 2009 and has been involved in the production of analytical sciences courses, as well as contributing to the presentation of a number of science courses including medicinal chemistry.

  3. Spotlight on modern transformer design

    CERN Document Server

    Georgilakis, Pavlos S

    2009-01-01

    Increasing competition in the global transformer market has put tremendous responsibilities on the industry to increase reliability while reducing cost. This book introduces an approach to transformer design using artificial intelligence (AI) techniques in combination with finite element method (FEM).

  4. School Shootings in Policy Spotlight

    Science.gov (United States)

    Maxwell, Lesli A.

    2006-01-01

    The three school shootings that left a principal and six students dead in less than a week have sparked a barrage of pledges from national and state political leaders to tighten campus security. School safety experts urged caution against overreacting to the horrific, but rare, incidents in rural schools in Colorado, Pennsylvania, and Wisconsin.…

  5. Spotlight on quantum black holes

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    Particle theorists are getting unusually excited these days as new ideas and different approaches converge in the search for a picture which describes all the underlying mechanisms of Nature. Although the final picture has yet to emerge, the outline is becoming clearer. While the intellectual mountain range to be crossed was once intimidating, these new developments are beginning to point to a way over. A series of recent topical workshops have highlighted these developments and leap-frogged ahead - including String 95 at the University of Southern California, Los Angeles, this spring and a conference on Mirror Symmetry and S-duality held in June at Trieste's International Centre for Theoretical Physics. Closing the Trieste meeting, prominent theorist Ed Witten said ''this is one of the most exciting conferences in which I have ever participated''. With profound problems to be overcome, the new ideas now on the market at first look very unconventional. Classical electromagnetism exploits the parallels between electricity and magnetism but accepts the everyday wisdom that free magnetic charges (magnetic monopoles) do not exist. Particle theorists are not so sure, and for a long time magnetic monopoles have been tentatively included on the theoretical menu. The role of these monopoles has now become crucial. Also playing a central role is the idea of supersymmetry. In a quantum theory, basic particles, like quarks and leptons (fermions), interact through force-carrying particles (bosons) like the photon of electromagnetism, the W and Z of the weak nuclear force and the gluon of the strong inter-quark force. In supersymmetry, each fermion has additional boson partners, and vice versa. So far, no evidence for supersymmetry has been found, but the underlying ideas are so convincing that its existence is almost taken for granted among theorists. Supersymmetry would have governed the mechanics of the Big Bang, but as the temperature fell, supersymmetry 'froze' out and became almost invisible. In the late 1970s, Klaus Montonen and David Olive pointed out that if magnetic monopoles are included in a supersymmetric quantum picture, the electric and magnetic sectors are in some respects mutually complementary. Magnetic charges provide additional calculational leverage, sidestepping the traditional problem of having to solve the equations of the theory through sometimes unsatisfactory approximations. Subsequently, the ideas were enlarged to include 'dyons' - particles having both electric and magnetic charges, providing a much richer scenario

  6. Get prepared for the spotlight

    CERN Multimedia

    2009-01-01

    With the re-start of the LHC, not just the scientific community will have its eyes on CERN. Hundreds of journalists will continue to ensure high media coverage of the Lab’s activities. As the DG stated in his message in issue No.15 of The Bulletin, "we have a greater degree of responsibility in the way we communicate". The Media Training organized by the Press Office gives you the chance to learn how to do it.If you are a scientist, engineer, computer expert or in any way a person likely to interact with the media, you might get the chance to be involved in the activities of the Press Office, which welcomes over 500 journalists from all over the world every year. "We are looking for enthusiastic scientists, researchers, engineers and IT specialists who are eager to explain their work to journalists", explains Renilde Vanden Broeck, Press Officer. "Last year we dealt with more than 700 media on-site. A regular media visit covers the main activities of CERN, namely accelerat...

  7. Refugee scientists under the spotlight

    Science.gov (United States)

    Extance, Andy

    2017-07-01

    Thousands of people are forced to flee war-torn regions every year, but the struggles of scientists who have to leave their homeland often goes under the radar. Andy Extance reports on initiatives to help

  8. CERN communication in the spotlight

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    A rich harvest of important prizes has recently been awarded to CERN communication efforts. The list includes: the European Excellence Award 2010, the physics.org “people’s choice” award for the best children's website, and two prizes in the UK Recruitment Advertising Awards for 2011. Given the high expectations surrounding CERN's future physics results, there is little doubt that the old refrain “the best is yet to come” also applies to communication at CERN.   Marie Anne Bugnon and Antonella del Rosso, from the Communication Group, accept the 2010 European Excellence Award for LHC First Physics. In recent years, efforts to communicate as much and as well as possible have been stepped up at CERN – across all communities – and the fruits have come little by little. First of all, awards represent the recognition of the public, which, on different levels, has shown that it appreciates CERN’s efforts to...

  9. Neutrino physics in the spotlight

    CERN Document Server

    2009-01-01

    Following on from the Council recommendation made in Lisbon in 2006 and responding to the needs of a large community of scientists, CERN will organize the European Strategy for Future Neutrino Physics workshop on 1-3 October. One of the main goals of the workshop is to start establishing a roadmap for the coherent participation of Europe in neutrino physics."The format of the workshop will consist of invited talks to present the current situation and future possibilities; unlike other workshops, 30% of the time will be reserved for discussion", explains Ewa Rondio from the organising committee. "Resources for future neutrino experiments will be difficult to acquire. A coordinated approach and the participation of a large community of interested scientists are undoubtedly crucial factors". The workshop will be the opportunity to highlight the areas where substantial research and development activities are required in order to design the facilities of the next decade. "The w...

  10. Special Spotlight: 2014 AACR Conference

    Science.gov (United States)

    A focus of the 7thAACR annual conference was community engagement and how to attract and retain racial and ethnic populations. Three community health educators from CRCHD’s National Outreach Network program delivered presentations in this area.

  11. Interpreting Bodies. Elena Castellani (ed.) Interpreting Bodies: Classical and Quantum Objects in Modern Physics (Princeton: Princeton University Press, 1998), viii+329 pp., ISBN 0-691-01725-5, paperback, 19.95 US, ISBN 0-691-01724-7, cloth, 65.00 US.

    Science.gov (United States)

    Ruetsche, Laura

    The objects of the empirical science known as particle physics are not like objects ordinarily conceived. Physicists' particles can enter states strangely entangled with those of other particles; they can obey statistics which suggest that they lack genidentity; their properties (some think) are created in measurement, or (others think) can only be limned from the symmetries of the theory describing them. 'The implications of contemporary physical theories for the debate on the nature of objects' provides 'the central theme' (p. 4) of Interpreting Bodies, editor Elena Castellani's new collection of essays. Contributions to the volume vary dramatically in vintage (Born's and Reichenbach's are well into middle age; others appear here for the first time); in approach (the collection includes Giuliano Toraldo diFrancia's nine-page history of the object concept from Democritus to d'Espagnat, Peter Mittelstaedt's discussion of the Kantian constitution of quantum objects, and Giulo Peruzzi's explication of the scattering cross section and its role in experimental particle physics); and in intended audience. Lacking the space to treat each contribution in turn, I will focus on those dealing with the problem of the One and the Many.

  12. La profesionalización de los Docentes en los procesos de Acreditación de la Universidad Estatal Península Santa Elena. Propuesta Centro de Capacitación Docente- Metodológico de la UPSE.

    Directory of Open Access Journals (Sweden)

    Jimmy Candell

    2015-10-01

    The current transformations taking place in education in general and particularly in higher education, as part of the educational policies of our country, and the results achieved by UPSE in the inspections made by the former CONEA and CONESUP in 2009, which placed UPSE under category “E”, with 33 indicators in the academic area assessed as unsatisfactory, demand the need to refine the improvement plan for the professional performance of teachers.  This research responds to one of the main priorities in relation to the continuous training of teachers with a view to the appropriate development of the professionalization process of the teachers in order to meet the institution’s evaluation and accreditation.   The methodology used in this project is that of a feasible project based on a qualitative-quantitative research, results obtained in the field research show the necessity of perfecting the process of professional improvement of the faculty.  In this sense the author proposes the creation of the Methodological Training Center of UPSE.  A diagnosis of the educational reality is carried out from a system of dimensions and indicators and the main strengths and limitations are analyzed in order to solve the problem.  The main characteristics and requirements are proposed and founded for the implementation of the Methodological Training Center of UPSE for the continuous training of teachers through the integration of improvement, methodological work and scientific activity.  Its components and actions are explained for the development of professional competencies of the teachers at PENINSULA DE SANTA ELENA State University.   Verification on a theoretical level has made it possible to recognize its viability, with a view to improving the teaching staff, considering the demands of Higher Education in Ecuador

  13. Investigation on the separability of slums by multi-aspect TerraSAR-X dual-co-polarized high resolution spotlight images based on the multi-scale evaluation of local distributions

    Science.gov (United States)

    Schmitt, Andreas; Sieg, Tobias; Wurm, Michael; Taubenböck, Hannes

    2018-02-01

    Following recent advances in distinguishing settlements vs. non-settlement areas from latest SAR data, the question arises whether a further automatic intra-urban delineation and characterization of different structural types is possible. This paper studies the appearance of the structural type ;slums; in high resolution SAR images. Geocoded Kennaugh elements are used as backscatter information and Schmittlet indices as descriptor of local texture. Three cities with a significant share of slums (Cape Town, Manila, Mumbai) are chosen as test sites. These are imaged by TerraSAR-X in the dual-co-polarized high resolution spotlight mode in any available aspect angle. Representative distributions are estimated and fused by a robust approach. Our observations identify a high similarity of slums throughout all three test sites. The derived similarity maps are validated with reference data sets from visual interpretation and ground truth. The final validation strategy is based on completeness and correctness versus other classes in relation to the similarity. High accuracies (up to 87%) in identifying morphologic slums are reached for Cape Town. For Manila (up to 60%) and Mumbai (up to 54%), the distinction is more difficult due to their complex structural configuration. Concluding, high resolution SAR data can be suitable to automatically trace potential locations of slums. Polarimetric information and the incidence angle seem to have a negligible impact on the results whereas the intensity patterns and the passing direction of the satellite are playing a key role. Hence, the combination of intensity images (brightness) acquired from ascending and descending orbits together with Schmittlet indices (spatial pattern) promises best results. The transfer from the automatically recognized physical similarity to the semantic interpretation remains challenging.

  14. GDA sinu abimees pakendil / Piret Jaaks ; kommenteerinud Elena Burm

    Index Scriptorium Estoniae

    Jaaks, Piret, 1980-

    2010-01-01

    Euroopa Komisjoni kokku kutsutud toitumisteadlaste komisjoni Eurodiet poolt koostatud GDA toitumisjuhist toiduainepakenditel, mis aitab jälgida toote- või joogiportsjoni osatähtsust päevasest soovitatavast kalorite ning olulisemate toitainete kogusest

  15. Liberarse de la escuela. Historia de vida de Elena

    OpenAIRE

    Calderon-Almendros, Ignacio

    2015-01-01

    No podemos construir una pedagogía al margen de las personas. Como respuesta a esta sencilla premisa, la obra que se presenta en estas páginas expone la voz transparente de una adolescente, su madre y sus amigos acerca de la experiencia del fracaso escolar. Es un reconocimiento de sus voces y del valor de lo que dicen. El peso de la institución escolar para algunas personas y colectivos es demoledor, y se aleja de cualquier pretensión educativa. La distancia de las exigencias de la esc...

  16. Review: Dorothée Ninck Gbeassor, Heidi Schär Sall, David Signer, Daniel Stutz & Elena Wertli (1999. Überlebenskunst in Übergangswelten: ethnopsychologische Betreuung von Asylsuchenden [The Art of Surviving in Transitional Worlds: Counselling for the Asylum Seekers

    Directory of Open Access Journals (Sweden)

    Victoria Hegner

    2002-05-01

    Full Text Available The book "Überlebenskunst in Übergangswelten" [The Art of Surviving in Transitional Worlds] is the first of two recent publications from the Ethnological-Psychological Centre in Zurich. The branch of the Asylum-Organisation of the Canton Zurich offers people who have fled their home country and who are now suffering from psychological crisis, inpatient or in-house or ambulatory treatment. The refugees physically escaped war, torture and/or imprisonment. However, they are unable to master the difficult process of migration and gradual arrival integration into the new, cultural and social contexts in Switzerland. As a result they have psychological problems, which make it impossible for them to live a "normal" everyday life. In three houses of the Centre, the so-called Foyers, they can find potential help. The migrants meet with a team of five ethno-psychologists, which uses ethnological and psychological approaches in order to understand the newcomers' problems. Within their work, the professionals of the Centre have developed a theoretical and methodological repertoire, which is of model-character not only within Switzerland but also for other countries. David SIGNER focuses in his article on characteristic conflicts and patterns of interaction in everyday life in the Foyers. The author emphasises the need to be open for all sorts of perception and communication. Furthermore, he sheds light on the various "pitfalls" in trying to create interaction. Elena WERTLI's text concentrates on refugees suffering from suicidal crisis. She explicates that a continued dialog is sometimes of more help for people in extreme psychological situations than a fast intervention. Daniel STUTZ' approach towards the problems of a Kurdish family is to first reconstruct the latter's individual life histories. The method enables him to explain the ongoing physical problems and the family's growing fear to get infected by bacteria as an expression of the couple's fear

  17. Madagascar's open landscapes under the spotlight

    African Journals Online (AJOL)

    pharmaceuticals, and emblematic landscapes for tourism. This special issue consists of six contributions ... Switzerland. Indian Ocean e-Ink. Promoting African Publishing and Education www.ioeink.com. Missouri Botanical Garden (MBG). Madagascar Research and Conservation Program. BP 3391. Antananarivo, 1 01 , ...

  18. Program Spotlight: CRCHD Mock Grant Review

    Science.gov (United States)

    The NCI Center to Reduce Cancer Health Disparities (CRCHD) held a Professional Development Workshop for its Continuing Umbrella of Research Experience (CURE) scholars on June 23-24, 2014, in Rockville, Maryland.

  19. "Crazy for You." Spotlight on Theater Notes.

    Science.gov (United States)

    Carr, John C.

    This booklet presents a variety of materials concerning the musical play "Crazy for You," a recasting of the 1930 hit, "Girl Crazy." After a brief historical introduction to the musical play, the booklet presents biographical information on composers George and Ira Gershwin, the book writer, the director, the star…

  20. The ATLAS cavern in the spotlight

    CERN Document Server

    On Wednesday, 4th June, the President of the Swiss Confederation, Pascal Couchepin, inaugurated the world's largest experimental cavern, which is to house the ATLAS detector in 2007, and announced Switzerland's gift to CERN of the "Palais de l'Equilibre".

  1. Spotlight on depression: a Pharma Matters report.

    Science.gov (United States)

    D'Souza, P; Jago, C

    2014-03-01

    Depression represents a huge pharmaceutical market opportunity. There are approximately 350 million people worldwide with depression, and it is the leading cause of disability in the world. In the U.S., 9.1% of the population suffers from depression. Globally, fewer than half of depression sufferers receive treatment for their illness, and in some countries this figure falls to fewer than 1 in 10. The high incidence rate, combined with limited market penetration, makes depression a high potential market for pharmaceuticals. However, companies developing drugs for depression also face a number of serious challenges. Psychosocial treatment options remain the preferred first-line therapy ahead of medication-and when it comes to drug treatment, the abundance of generic options available has significantly contributed to halving the value of the branded antidepressant market over recent years. Another hurdle faced by new drugs is the requirement that all antidepressants carry a black-box warning regarding the increased risk of suicide in children, adolescents and young adults, which limits their use in this population. Switching between medications presents both an opportunity and a challenge, as a significant number of patients will switch away from their first medication within the first year of treatment. The lack of complete understanding of why depression occurs also makes this area a difficult one, although it opens the door for the development of drugs with novel mechanisms of action. Copyright 2014 Prous Science, S.A.U. or its licensors. All rights reserved.

  2. Spotlight on acupuncture in laboratory animal medicine

    Directory of Open Access Journals (Sweden)

    Magden ER

    2017-08-01

    Full Text Available Elizabeth R Magden Department of Veterinary Sciences, Michale E Keeling Center for Comparative Medicine and Research, University of Texas MD Anderson Cancer Center, Bastrop, TX, USA Abstract: Acupuncture has been practiced for thousands of years, although it is only in the past century that science has worked to unravel the mechanisms behind its use. Literature supporting the efficacious use of acupuncture to treat a variety of conditions has been and continues to be published, including the randomized controlled studies we all appreciate when practicing evidence-based medicine. The use of acupuncture in veterinary medicine has paralleled the trends observed in people, with an increasingly common use to remedy specific medical conditions. These conditions are commonly related to neurological dysfunction or orthopedic pain. Although pain relief is the most common use of acupuncture, numerous other conditions have been shown to improve with this therapy. Laboratory animals are also benefiting from acupuncture. Its use is starting to be incorporated into research settings, although there is still further progress to be made in this field. Acupuncture has been shown to improve clinical conditions and quality of life in laboratory animals, and should be considered as a tool to treat laboratory animals with conditions known to benefit from therapy. Here we review the history, mechanisms of action, and use of acupuncture to treat veterinary patients and laboratory animals. Keywords: acupuncture, laboratory animals, nonhuman primates

  3. Students as Active Historians. Spotlight Feature

    Science.gov (United States)

    Dopke-Wilson, MariRae

    2006-01-01

    Coming up with interesting information literacy lessons can be challenging for the high school librarian. If school librarians have taught their upper class students well, most are prepared to navigate their way successfully through libraries and Internet resources. In this article, the author explores a unique high school project that resulted in…

  4. Corruption: history and future in the spotlight

    OpenAIRE

    Sanudo, Martha

    2016-01-01

    Rezension zu: Frank Vogl, Waging War on Corruption (Lanham: Rowman & Littlefield Publishers, 2012). Shaazka Beyerle, Curtailing Corruption, People Power for Accountability and Justice (Boulder: Lynne Rienner Publishers, 2014)

  5. Global women's health: a spotlight on caregiving.

    Science.gov (United States)

    Berg, Judith A; Woods, Nancy Fugate

    2009-09-01

    Caregiving is a women's health issue globally, as many more women than men are informal caregivers. Caregiving related to gender role socialization, burden, and economic and health consequences has been discussed in the literature. Together this body of work demonstrates some positive but mainly negative consequences to the health and economic circumstances of women. Overall achievement of the United Nations' Millennium Development Goals has important implications for informal caregivers globally, because achievement of these goals is essential to reducing the undue burden, the lost opportunities, and the injustice of health care systems that take advantage of women's volunteer caregiving.

  6. 10 September: CERN in the media spotlight

    CERN Multimedia

    2008-01-01

    Media organisations around the world are holding their breath in anticipation for the moment the LHC circulates its first proton beam. On 10 September, the Globe and the experiment control rooms will not only be packed full of eager physicists and electrical engineers, but also journalists. Their aim? Capturing the first moments in the life of the LHC and beaming it around the world for millions of people to see! "Almost 250 journalists from 33 countries will be here on 10 September. The start-up of the LHC is not just a scientific landmark, but a news story that captures the imagination of people everywhere," comments James Gilles, the Communication Group leader. A media centre will be set up in the Globe along with a large screen showing the activity in the CCC. Throughout the day a member of the operations team will be on hand to explain what is happening. The first injection of the beam into the machine will be between 9:00 and 10:00 a. m., with the main objective...

  7. Fat & fabulous: bifunctional lipids in the spotlight.

    Science.gov (United States)

    Haberkant, Per; Holthuis, Joost C M

    2014-08-01

    Understanding biological processes at the mechanistic level requires a systematic charting of the physical and functional links between all cellular components. While protein-protein and protein-nucleic acid networks have been subject to many global surveys, other critical cellular components such as membrane lipids have rarely been studied in large-scale interaction screens. Here, we review the development of photoactivatable and clickable lipid analogues-so-called bifunctional lipids-as novel chemical tools that enable a global profiling of lipid-protein interactions in biological membranes. Recent studies indicate that bifunctional lipids hold great promise in systematic efforts to dissect the elaborate crosstalk between proteins and lipids in live cells and organisms. This article is part of a Special Issue entitled Tools to study lipid functions. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. Spotlight on the 9-valent HPV vaccine.

    Science.gov (United States)

    Lopalco, Pier Luigi

    2017-01-01

    Starting in 2006, vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries. Two vaccines have been successfully used, a bivalent vaccine targeting HPV-related cancers (bHPV) and a quadrivalent vaccine (qHPV) targeting both HPV-related cancers and genital warts. Between December 2014 and June 2015, a new nonavalent HPV vaccine (9vHPV) was granted marketing authorization in the USA and Europe. The 9vHPV was developed from the qHPV and includes five additional HPV types that should increase the level of protection toward HPV-related cancers. Efficacy and/or immunogenicity of 9vHPV has been assessed in eight clinical studies. The 9vHPV vaccine induced a very robust immune response against all vaccine types, with seroconversion rates close to 100%. The safety profile of 9vHPV is comparable to that of qHPV. Local reactions, especially swelling, have been more frequently reported after 9vHPV than qHPV, and this slightly increases when the 9vHPV is coadministered with other vaccines. The additional coverage offered by the 9vHPV may prevent a significant proportion of HPV-related cancers (variable between 8% and 18%) depending on the local distribution of high-risk HPV types in the population. It is impossible, at present, to anticipate the actual impact of the wide use of the 9vHPV in comparison with the bHPV or the qHPV, since it depends on many variables including duration of protection, potential cross-protection toward nonvaccine types, and herd immunity effect.

  9. Spotlight on the 9-valent HPV vaccine

    Directory of Open Access Journals (Sweden)

    Lopalco PL

    2016-12-01

    Full Text Available Pier Luigi Lopalco Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy Abstract: Starting in 2006, vaccination against human papillomavirus (HPV has been progressively implemented in most developed countries. Two vaccines have been successfully used, a bivalent vaccine targeting HPV-related cancers (bHPV and a quadrivalent vaccine (qHPV targeting both HPV-related cancers and genital warts. Between December 2014 and June 2015, a new nonavalent HPV vaccine (9vHPV was granted marketing authorization in the USA and Europe. The 9vHPV was developed from the qHPV and includes five additional HPV types that should increase the level of protection toward HPV-related cancers. Efficacy and/or immunogenicity of 9vHPV has been assessed in eight clinical studies. The 9vHPV vaccine induced a very robust immune response against all vaccine types, with seroconversion rates close to 100%. The safety profile of 9vHPV is comparable to that of qHPV. Local reactions, especially swelling, have been more frequently reported after 9vHPV than qHPV, and this slightly increases when the 9vHPV is coadministered with other vaccines. The additional coverage offered by the 9vHPV may prevent a significant proportion of HPV-related cancers (variable between 8% and 18% depending on the local distribution of high-risk HPV types in the population. It is impossible, at present, to anticipate the actual impact of the wide use of the 9vHPV in comparison with the bHPV or the qHPV, since it depends on many variables including duration of protection, potential cross-protection toward nonvaccine types, and herd immunity effect. Keywords: human papillomavirus vaccine, immunogenicity, vaccine safety, cervical cancer, head and neck cancer, genital warts

  10. Spotlight on the 9-valent HPV vaccine

    OpenAIRE

    Lopalco, Pier Luigi

    2016-01-01

    Pier Luigi Lopalco Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy Abstract: Starting in 2006, vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries. Two vaccines have been successfully used, a bivalent vaccine targeting HPV-related cancers (bHPV) and a quadrivalent vaccine (qHPV) targeting both HPV-related cancers and genital warts. Between December 2014 and June 2015,...

  11. Southern gas boom takes UK spotlight

    Energy Technology Data Exchange (ETDEWEB)

    1984-06-11

    To encourage new offshore development needed to fill a gas supply gap that will emerge in the 1990s, British Gas Corp. is offering higher prices for gas produced by both foreign and United Kingdom-based companies in the UK sector of the North Sea. A rundown of recent exploration and development shows that in just 1 year, companies have proposed nine new development projects, primarily in fields previously considered unprofitable. Operators are also reappraising other finds from the 1970s and embarking on a sizable wildcat program.

  12. Fatal attraction: rare species in the spotlight.

    Science.gov (United States)

    Angulo, Elena; Deves, Anne-Laure; Saint Jalmes, Michel; Courchamp, Franck

    2009-04-07

    The exploitation of rare and endangered species can end in the species's extinction because the increased value people associate with rarity increases the economic incentive to exploit the last individuals, creating a positive feedback loop. This recently proposed concept, called the anthropogenic Allee effect (AAE), relies on the assumption that people do value rarity, but this remains to be established. Moreover, it also remains to be determined whether attraction to rarity is a trait confined to a minority of hobbyists (e.g. wildlife collectors, exotic pet owners) or characteristic of the general public. We estimated how much the general public valued rare species compared with common ones, using five different metrics related to personal investment: time spent, physical effort, unpleasantness, economic investment and risk. We surveyed the visitors of a zoo. To see the rare species, the visitors to the zoo invested more time in searching and contemplation, they were ready to expend more physical effort, they tolerated more unpleasant conditions, they were willing to pay more and, finally, they risked more to obtain (steal) a rare species. Our results provide substantial evidence of how the general public places more value on rare species, compared with common species. This confirms the AAE as an actual process, which in addition concerns a large part of the population. This has important consequences for the conservation of species that are rare now, or that could become so in the future.

  13. International Geneva: intellectual property under the spotlight

    CERN Multimedia

    Antonella Del Rosso

    2015-01-01

    On 17 July, the Director-General of the World Intellectual Property Organization (WIPO), Francis Gurry, will present his organisation to CERN people. You are invited to take part and discover the UN’s specialised agency for services, policy, information and cooperation relating to intellectual property.   This is the third in the “International Geneva comes to CERN” series of seminars, which presents other Geneva-based international organisations to CERN’s internal audience. In his seminar, Gurry will discuss how WIPO finds the right balance between the interests of innovators and the wider public and how the IP system aims to foster an environment in which creativity and innovation can flourish. In 2010, CERN and WIPO signed a collaboration agreement designed to strengthen the partnership between the two organisations. The agreement focused on four main areas for cooperation, namely: capacity building, awareness raising and knowledge sharing; tra...

  14. Spotlight on olfactory dysfunction in Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Rodríguez-Violante M

    2017-06-01

    Full Text Available Mayela Rodríguez-Violante,1,2 Natalia Ospina-García,1,2 Christian Pérez-Lohman,1,2 Amin Cervantes-Arriaga1,2 1Movement Disorders Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; 2Clinical Neurodegenerative Research Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico Abstract: Olfactory dysfunction is frequent in Parkinson’s disease (PD. A correlation between olfactory dysfunction and the pathophysiological process of the disease has been confirmed. On the other hand, olfaction disturbances are also prevalent in other neurodegenerative diseases, and may be related to other factors such as gender, age, smoking, and trauma. Clinically, hyposmia is commonly assessed by smell identification testing. Good diagnostic accuracy has been widely reported, but differences in sensitivity and specificity due to sociocultural factors have also been reported. Since hyposmia may be present before the onset of motor symptoms, it has the potential to serve as a biomarker for the identification of subjects at risk of developing PD. Several studies have been conducted to assess the utility of smell testing as an isolated or combined biomarker for this end. Finally, severe olfactory dysfunction has been associated with faster disease progression and higher risk of cognitive decline in patients with PD. Olfactory dysfunction assessment in PD will continue to be relevant in research and clinical practice. Keywords: Parkinson’s disease, olfaction, smell identification test, biomarker 

  15. Spotlight census of the red fox (Vulpes vulpes and the domestic cat (Felis catus in three sample areas of the Marches region (Central Italy / Censimento notturno di Volpe (Vulpes vulpes e di Gatto domestico (Felis catus in tre aree campione delle Marche

    Directory of Open Access Journals (Sweden)

    Massimo Pandolfi

    1991-07-01

    Full Text Available Abstract In order to evaluate the density of the red fox and of the domestic cat, 55 transects were made from 1986 to 1989 using spotlight census method in three sample areas. The mean density of foxes agreed substantially with its biological cycle and the hightes values (2.01 foxes/km² in spring and 4.3 foxes/km² in winter were recorded in the study area with the better natural characteristics. Foxes selected the shrub woodland (macchia all year round, the inhabited area in spring. The domestic cat was widely spread and abundant, and selected especially inhabited areas where the density varied from 4.27 cats/km² (in winter to 12.42 cat/km² (in spring. Riassunto Dal 1986 al 1989, con il metodo dei percorsi notturni con fari, sono stati effettuati complessivamente 55 conteggi in tre aree campione per valutare la densità della Volpe (Vulpes vulpes e del Gatto domestico (Felis catus nonché le loro preferenze ambientali limitatamente ad una zona campione. Per la Volpe le densità medie rilevate sono sostanzialmente in accordo con il ciclo biologico della specie e quelle più elevate (2,O1 volpi/km² in primavera e 4,3 volpi/km² in inverno sono state registrate nella zona campione con maggior presenza di boschi ed aree incolte. La Volpe seleziona le zone con vegetazione "di macchia" in ogni periodo dell'anno, e le aree abitate in primavera. Per il Gatto domestico le densità rilevate evidenziano la presenza di una diffusa ed abbondante popolazione. La specie mostra una spiccata preferenza per le aree abitate dove raggiunge densità di 4,27 individui/km² e 12,42 individui/km² in inverno e primavera rispettivamente.

  16. Presentación. Alberto Elena y las miradas a los cines periféricos / Presentation. Alberto Elena and the Views on Peripheral Cinemas

    Directory of Open Access Journals (Sweden)

    Minerva Campos

    2016-12-01

    Full Text Available «Llegará un día en que el cine habrá cambiado el mundo más que la invención de la pólvora, la electricidad o el descubrimiento de nuevos continentes. El cine permitirá a la gente repartida por los más remotos confines de la Tierra conocerse y apreciarse mejor. El cine reconciliará las diferencias de opinión y contribuirá de forma decisiva a la realización de los ideales de la Humanidad. Es fundamental que concedamos al cine la importancia que merece». Mustafa Kemal Atatürk (1937

  17. Implantación de guías de buenas prácticas en España. Programa de centros comprometidos con la excelencia en cuidados / Best Practice Guidelines Implementation in Spain. Best Practice Spotlight Organizations / Implementação de manuais sobre boas práticas na Espanha. Programa dos Centros comprometidos com a excelência no atendimento

    Directory of Open Access Journals (Sweden)

    Laura Albornos-Muñoz, BS.

    2015-03-01

    Full Text Available Introducción: El programa de implantación de Guías de Buenas Prácticas, denominado en España Centros Comprometidos con la Excelencia en Cuidados®, se inició en 2010 tras un acuerdo de colaboración entre la Unidad de Investigación en Cuidados de Salud (Investén-isciii de España, el Centro Colaborador Español del Instituto Joanna Briggs para los Cuidados de Salud basados en la Evidencia y la Registered Nurses' Association of Ontario (RNAO, siguiendo los mismos principios que el programa Best Practice Spotlight Organizations (BPSO® iniciado por RNAO, en Canadá, en 1999. Objetivo: Describir la implantación de Guías de Buenas Prácticas de RNAO en el marco del programa de Centros Comprometidos con la Excelencia en Cuidados® (Best Practice Spotlight Organizations® en España. El programa tiene como objetivo fomentar, facilitar y apoyar la implantación, evaluación y mantenimiento de buenas prácticas en cuidados, para el periodo 2012-2014. Metodología y Resultados: se han seleccionado 8 instituciones de salud y una universidad que implantan las guías de buenas prácticas de RNAO en función de sus necesidades. Tras los 24 primeros meses de implantación se ha formado a los profesionales de salud, constituido grupos estables de trabajo, desarrollado o actualizado protocolos de cuidados y registros correspondientes, también se han evaluado de forma sistemática los resultados de proceso y de salud de los pacientes. También se han difundido activamente los principales logros del programa. Conclusiones: Los candidatos a Centros Comprometidos con la Excelencia en Cuidados® están realizando un gran esfuerzo y los resultados empiezan a mostrar que son positivos, con una creciente cultura de cuidados basados en la evidencia, y el impulso de la investigación y el inicio de un trabajo colaborativo en red. [Albornos-Muñoz L, González-María E, Moreno-Casbas T. Implantación de guías de buenas prácticas en España. Programa de

  18. El lenguaje figurativo de antes y de ahora en la provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Mónica Tomalá

    2014-12-01

    appropriate, by the computer, since all written work usually is printed . And if it comes to writing standards, the computer does its job, he helps the person who writes placing automatically the respective punctuation, intonation and possibly to the auxiliary, on the other hand, corrects him without asking, the structure of each word.

  19. Images of women in advertising : dynamics and consumer perceptions / Elena Pruvli

    Index Scriptorium Estoniae

    Pruvli, Elena

    2003-01-01

    Kaanel ajak. ilmumisaeg 2002/2003. Ülevaade naise imago kujutamisest reklaamis, erinevaid naisetüüpe esitavate reklaamide vastuvõtmisest ja mõjudest hoiakutele ning käitumisele EBS-is läbiviidud uuringu põhjal

  20. A new tropical Oligocene dolphin from Montañita/Olón, Santa Elena, Ecuador.

    Science.gov (United States)

    Tanaka, Yoshihiro; Abella, Juan; Aguirre-Fernández, Gabriel; Gregori, Maria; Fordyce, R Ewan

    2017-01-01

    A new small probable Oligocene dolphin from Ecuador represents a new genus and species, Urkudelphis chawpipacha. The new taxon is known from a single juvenile skull and earbones; it differs from other archaic dolphins in features including widely exposed frontals at the vertex, a dorsally wide open vomer at the mesorostral groove, and a strongly projected and pointed lateral tuberosity of the periotic. Phylogenetic analysis places it toward the base of the largely-extinct clade Platanistoidea. The fossil is one of a few records of tropical fossil dolphins.

  1. Book reviews: Gurgu Elena – The globalization of the economic activity. Relations and tendencies

    Directory of Open Access Journals (Sweden)

    Constantin MECU

    2011-09-01

    Full Text Available As we know, the economic globalisation, correlated to other similar processes, changes the world’s configuration, if that hasn’t happened yet. People worldwide seem to increasingly realize that they belong to the world itself and not to small communities, that their development does not depend on the development of the communities, but on decision-making processes they never knew existed. In this respect, I mention a relevant case. The thousands of Romanian female textile workers active in lohn manufacturing for many years lost their jobs on account of such unknown forces. In fact, these processes emerge following production globalisation.

  2. A new tropical Oligocene dolphin from Montañita/Olón, Santa Elena, Ecuador

    Science.gov (United States)

    Abella, Juan; Aguirre-Fernández, Gabriel; Gregori, Maria; Fordyce, R. Ewan

    2017-01-01

    A new small probable Oligocene dolphin from Ecuador represents a new genus and species, Urkudelphis chawpipacha. The new taxon is known from a single juvenile skull and earbones; it differs from other archaic dolphins in features including widely exposed frontals at the vertex, a dorsally wide open vomer at the mesorostral groove, and a strongly projected and pointed lateral tuberosity of the periotic. Phylogenetic analysis places it toward the base of the largely-extinct clade Platanistoidea. The fossil is one of a few records of tropical fossil dolphins. PMID:29261688

  3. Meistri kutsumine / Taavi Talve, Indrek Köster ; intervjueerinud Elena Šmakova

    Index Scriptorium Estoniae

    Talve, Taavi

    2009-01-01

    Loomingulise ühenduse Johnson ja Johnson - Taavi Talve, Indrek Köster - näitus "Meistri kutsumine" Hobusepea Galeriis 27. aprillini. Autorid 2006. aastal alustatud Paldiski linnaruumi ja selle elanikke kaasavast projektist, mille lõppeesmärk on luua Paldiskisse Amandus Adamsoni skulptuur. Linnaelanike lemmikuks osutus teos "Laeva viimne ohe", mille savist suurenduse modelleerib Mare Mikof

  4. Muid võimalusi ei ole! / Kristina Norman, Marco Laimre ; intervjueerinud Elena Šmakova

    Index Scriptorium Estoniae

    Norman, Kristina, 1979-

    2009-01-01

    53. Veneetsia biennaalil "Making Worlds" ("Konstrueerides maailmu") Eestit esindavast Kristina Normani Tõnismäe pronkssõduri monumenti käsitlevast kunstiprojektist "After-War" ("Järelsõda"). Projekti kuraator Marco Laimre. Eesti ekspositsioon on avatud Palazzo Malipieros 6. juunist 22. novembrini. Biennaali nõukogu otsustas anda suured Kuldsed Lõvid elutöö eest Yoko Onole ja John Baldessarile

  5. Naistest ja solidaarsusest / Marge Monko, Liina Siib ; intervjueerinud Elena Šmakova

    Index Scriptorium Estoniae

    Monko, Marge, 1976-

    2009-01-01

    Töötavate naiste õigustest, töökeskkonnast ja sõltumisest tööhõivepoliitikast. Näitused Tallinnas: Marge Monko isikunäitus "Leib ja lilled" Draakoni Galeriis 8.-21. märtsini, Liina Siibi fotonäitus "Naine võtab vähe ruumi" Hobusepea Galeriis 18.-30. märtsini

  6. La herencia cultural en Santa Elena: etnicidad y memoria oral en La Libertad (Ecuador

    Directory of Open Access Journals (Sweden)

    Susana Anda

    2015-10-01

    This paper illustrates in a general and schematic way the cultural manifestations related to ethnicity and oral memory of the people in La Libertad in 2014. It does no intend to show a complete and detailed analysis of these aspects, however it seeks to highlight important cultural dynamics of the region. The research focused on ethnical construction and in the registration of cultural data of intangible heritage, understanding it as the practices, representations, expressions, knowledge and techniques that are transmitted from generation to generation among groups and individuals. The overall objective is to present some records of oral memory that conform part of the local intangible heritage, prioritizing a wide range of views on memory and social praxis of minorities, which often are left voiceless in the official history and without evidence in theoretical writing. To do this, an ethnographic study was necessary. The local testimonies provided key information for the reconstruction of their social, cultural, economic and ecological history. This research rescues cultural dynamics that are relevant in the construction of their social identity. Therefore, the registration of intangible heritage in La Libertad is not only the key for cultural safeguard, it also is a tool to build the basis for diagnostic, research and planning safeguard lines, providing transmission, recovery and dissemination of cultural knowledge in the context of constructing a plurinational and intercultural State.

  7. ANÁLISIS INTERNO DEL SECTOR TURÍSTICO DE DOS MANGAS, PROVINCIA DE SANTA ELENA

    Directory of Open Access Journals (Sweden)

    Jhony Yumisaca Tuquinga

    2017-01-01

    analyzes  the  empirical  raid  Dos  Mangas  in  this  activity  and  functionality  of  its  components  supply, demand,  competition  and  trends  that  revolve  around  these.  The  study  revolved  around  the  empirical method and systemic methodology that considers the tourism sector as a multiplier subsystem in the rest of the  part  economic  system,  for  which  on  the  one  hand  demand  is  analyzed  in  its  components  number  of tourists,  daily  expenditure  and  the  average  stay  and,  moreover  considering  the  offer  to  its  structure, management and its variable employment generated in the local tourism productive; resulted in a diagnosis of  tourism  system  of  the  commune  Dos  Mangas,  from  which  it  may  propose  strategies  for  tourism development in this destination offers.

  8. EVALUACIÓN PSICOSOCIAL DEL ADULTO MAYOR EN LA PROVINCIA DE SANTA ELENA. 2013

    OpenAIRE

    Jenny Sornoza

    2016-01-01

    Los adultos mayores constituyen un grupo poblacional significativo, que por tiempos ha estado desatendido, a pesar de que en el año 1990 se dicta la Ley del Anciano aún las personas mencionadas no gozan de todos los beneficios que contiene dicha ley ya que hasta la actualidad dicha ley no se aplica en su totalidad por falta de socialización, desconocimiento de sus beneficios e implementación de los espacios adecuados entre otras limitantes. El objetivo de la investigación fue el de Realizar u...

  9. Spotlight on middle childhood: Rejuvenating the ‘forgotten years’

    OpenAIRE

    Mah, V Kandice; Ford-Jones, E Lee

    2012-01-01

    Middle childhood, from six to 12 years of age, is often known as the ‘forgotten years’ of development because most research is focused on early childhood development or adolescent growth. However, middle childhood is rich in potential for cognitive, social, emotional and physical advancements. During this period, the brain is actively undergoing synaptic pruning and, as such, is constantly becoming more refined, a process that is heavily dependent on a child’s environment. This discovery open...

  10. Special Spotlight: The Alabama Project Celebrates Survivors and Their Communities

    Science.gov (United States)

    In recognition of cancer survivors and their families, CRCHD celebrates cancer survivorship with a focus in on The Alabama Project and its visual storytelling of the powerful impact of community in survivorship.

  11. Research Spotlight: Satellites monitor air pollutant emissions in China

    Science.gov (United States)

    Tretkoff, Ernie

    A new satellite study verifies that Chinese emission control efforts did reduce power plant emissions of sulfur dioxide (SO2), a harmful gas that causes acid rain and can form sulfate aerosols; these aerosols play an important role in the climate system by affecting clouds and precipitation patterns and altering the amount of sunlight that is reflected away from Earth.

  12. Spotlight on dream recall: the ages of dreams

    Directory of Open Access Journals (Sweden)

    Mangiaruga A

    2018-01-01

    Full Text Available Anastasia Mangiaruga, Serena Scarpelli, Chiara Bartolacci, Luigi De Gennaro Department of Psychology, University of Rome “Sapienza”, Rome, Italy Abstract: Brain and sleep maturation covary across different stages of life. At the same time, dream generation and dream recall are intrinsically dependent on the development of neural systems. The aim of this paper is to review the existing studies about dreaming in infancy, adulthood, and the elderly stage of life, assessing whether dream mentation may reflect changes of the underlying cerebral activity and cognitive processes. It should be mentioned that some evidence from childhood investigations, albeit still weak and contrasting, revealed a certain correlation between cognitive skills and specific features of dream reports. In this respect, infantile amnesia, confabulatory reports, dream-reality discerning, and limitation in language production and emotional comprehension should be considered as important confounding factors. Differently, growing evidence in adults suggests that the neurophysiological mechanisms underlying the encoding and retrieval of episodic memories may remain the same across different states of consciousness. More directly, some studies on adults point to shared neural mechanisms between waking cognition and corresponding dream features. A general decline in the dream recall frequency is commonly reported in the elderly, and it is explained in terms of a diminished interest in dreaming and in its emotional salience. Although empirical evidence is not yet available, an alternative hypothesis associates this reduction to an age-related cognitive decline. The state of the art of the existing knowledge is partially due to the variety of methods used to investigate dream experience. Very few studies in elderly and no investigations in childhood have been performed to understand whether dream recall is related to specific electrophysiological pattern at different ages. Most of all, the lack of longitudinal psychophysiological studies seems to be the main issue. As a main message, we suggest that future longitudinal studies should collect dream reports upon awakening from different sleep states and include neurobiological measures with cognitive performances. Keywords: dreaming, sleep mentation, development, sleep, continuity hypothesis, aging

  13. Fifty years of CERN history in the spotlight

    CERN Document Server

    2004-01-01

    The programme of events for CERN's Golden Jubilee year was officially unveiled at a press conference on 8 March. The first of these events took place the following day, when the Swiss commemorative postage stamp issued in the Laboratory's honour went on sale in post offices throughout Switzerland.

  14. Cameras instead of sieves for aggregate characterization : research spotlight

    Science.gov (United States)

    2012-01-01

    Michigan researchers explored the use of cameras and software that may eventually replace the use of screen sieves in sizing and assessing crushed aggregate for pavement construction. This research explored approaches to imaging aggregate as a way to...

  15. Spreading the word about the quick clearance law : research spotlight.

    Science.gov (United States)

    2012-09-01

    Motorists traditionally were taught to leave : their vehicles in place after a crash occurred : to make it easier for police to reconstruct : the incident and evaluate who was at fault. : However, the practice of leaving vehicles in : the roadway can...

  16. Spotlight on orlistat in the management of patients with obesity.

    Science.gov (United States)

    Curran, Monique P; Scott, Lesley J

    2005-01-01

    Orlistat is an inhibitor of gastrointestinal lipases and, therefore, prevents the absorption of dietary fat. This agent reduced weight in obese adults and adolescents with or without co-morbidities (including type 2 diabetes mellitus, hypercholesterolemia, hypertension, metabolic syndrome) who received up to 4 years of therapy in conjunction with a hypocaloric diet. In obese patients, orlistat in combination with a hypocaloric diet improved metabolic risk factors and reduced the risk of developing type 2 diabetes. Furthermore, this agent was cost effective in patients with obesity, particularly those with type 2 diabetes. Orlistat is generally well tolerated, with gastrointestinal adverse events being most commonly reported. Orlistat, in addition to lifestyle and dietary intervention, is thus an attractive option for the treatment of patients with obesity, especially those with associated co-morbidities or at risk of developing type 2 diabetes.

  17. American high school students shine a spotlight on CERN

    CERN Multimedia

    2008-01-01

    Between 2 and 7 April eighteen American high school students were let loose at CERN armed with video cameras. Their mission? To take on the role of broadcast journalists and inspire their peers across the US with short documentaries and blogs illuminating the work happening at the world’s most powerful particle accelerator. Members of the teams of budding physicists and broadcast journalists pose in front of the ATLAS detector.Following in the footsteps of professional journalists around the world, six teams of American high school students recently travelled to CERN to experience the increasing excitement in the run-up to the switch-on of the LHC. The six teams are from five states across the US and were the winners of a competition sponsored and funded by the US Department of Energy’s Office of Science and the National Science Foundation. Each team consists of three students plus a teacher, who combine their knowledge of ph...

  18. Soil stabilization with recycled materials improves subgrade performance : research spotlight.

    Science.gov (United States)

    2016-02-29

    The use of recycled materials for subgrade stabilization can provide the support needed for construction vehicle loading and more typical long-term traffic loading. This is a particular need in Michigan due to the prevalence of weak subgrade soils. U...

  19. Research Spotlight: Climate commitment in an uncertain world

    Science.gov (United States)

    Tretkoff, Ernie

    2011-02-01

    Even if humans immediately ceased emitting carbon dioxide (CO2) and other greenhouse gases, the planet would continue to warm, mainly due to thermal inertia of the world's oceans. This “climate commitment” has been of interest recently for both science and policy because it provides a measure of the minimum climate change the planet will face given human activity that has already occurred. Several studies have looked at what would happen if human emission of CO2 were halted, but these studies have overlooked the role of aerosols and non-CO2 greenhouse gases such as methane and nitrous oxide, which Armour and Roe include in a new study. If human emission stopped, atmospheric aerosols, which cool the planet by blocking light from the surface, would fall to preindustrial levels within weeks. However, non-CO2 greenhouse gases would remain in the atmosphere for decades to centuries, and elevated levels of CO2 would persist for millennia. (Geophysical Research Letters, doi:10.1029/2010GL045850, 2011)

  20. Study-Abroad Practices in the Spotlight, Again

    Science.gov (United States)

    Fischer, Karin

    2008-01-01

    A lawsuit that challenges the policy of Wheaton College, in Massachusetts, to charge its regular tuition to students studying abroad on less-costly independent programs is the latest sign of scrutiny into the finances of overseas education. Wheaton officials say the tuition policy is stated online and in program materials, maintaining that…

  1. Grantee Spotlight: Dr. Kolawole Okuyemi - Improving Cervical Cancer Screening Attitudes

    Science.gov (United States)

    Dr. Kolawole Okuyumi is studying cervical cancer screening attitudes and behaviors of African immigrants and refugees (Ethiopians, Nigerians, and Somalis) in Minnesota, and introducing “cancer” and “cervix” to their everyday vocabulary.

  2. January Monthly Spotlight: Cervical Health and Cervical Cancer Disparities

    Science.gov (United States)

    In January, CRCHD joins the nation in raising awareness for Cervical Health and Cervical Cancer Disparities. This month we share a special focus on NCI/CRCHD research programs that are trying to reduce cervical cancer disparities in underserved communities and the people who are spreading the word about the importance of early detection.

  3. What is Climate Leadership: Spotlight on Innovative Partnerships Webinar

    Science.gov (United States)

    Innovative Partnerships category winners from the 2015 Climate Leadership Award recipients discuss their innovative and collaborative initiatives and achievements that allowed them to measure the successes of their greenhouse gas reduction goals.

  4. Co-firing plans in the spotlight over biomass imports

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Spurred by the renewables obligation, coal-fired power stations with a capacity of over 20GW could be co-firing with biomass by early next year. But, with little of their fuel coming from dedicated energy crops, the generators are in danger of entering a minefield. UK wood panel manufacturers fear that their raw material costs will rise in the face of subsidised competition from power stations, while the generators' growing biomass imports are stirring sensitivities about rainforest destruction and dislocation of overseas markets for agricultural by-products. 1 tab., 2 photos.

  5. Spotlight on middle childhood: Rejuvenating the 'forgotten years'.

    Science.gov (United States)

    Mah, V Kandice; Ford-Jones, E Lee

    2012-02-01

    Middle childhood, from six to 12 years of age, is often known as the 'forgotten years' of development because most research is focused on early childhood development or adolescent growth. However, middle childhood is rich in potential for cognitive, social, emotional and physical advancements. During this period, the brain is actively undergoing synaptic pruning and, as such, is constantly becoming more refined, a process that is heavily dependent on a child's environment. This discovery opens the door to optimizing the experiences a child needs to provide themselves with a strong foundation for adulthood. The present article reviews the neurological changes that occur in middle childhood, their impact on overall development and how to implement this knowledge to augment a child's capabilities.

  6. THE ROLE OF SPOTLIGHT ON POVERTY AND INEQUALITY OF WOMEN

    Directory of Open Access Journals (Sweden)

    José Luis García-Horta

    2012-01-01

    Full Text Available Poverty is measured in terms of deficits and unmet basic needs using indicators such as the amount of food intake, income, access to health services, education and housing. This approach assumes that the well is only about the ability to meet the basic needs of food and clothing that are covered, traditionally, with the proceeds of the household head. However, when these revenues are not sufficient for the reproduction of the family, quality of life for women and children were severely affected.This article discusses the role of microfinance as one of the strategies adopted by some countries to reduce poverty in which women live. To achieve this objective, a survey to 82 users of microfinance ProMujer offered through one of its offices in Ixmiquilpan, State of Hidalgo. The results show that women are able to increase the amount of family income and to initiate a process of empowerment, however, and given the flexibility of the labor market, reproduce male domination through economic activities undertaken to use microcredit they are a palliative, but poverty in which they live is not resolved.

  7. Development and Use of Early Warning Systems. SLDS Spotlight

    Science.gov (United States)

    Curtin, Jenny; Hurwitch, Bill; Olson, Tom

    2012-01-01

    An early warning system is a data-based tool that helps predict which students are on the right path towards eventual graduation or other grade-appropriate goals. Through such systems, stakeholders at the school and district levels can view data from a wide range of perspectives and gain a deeper understanding of student data. This "Statewide…

  8. Stepping into the Spotlight: Collaborative Efforts towards Musical Inclusion

    Directory of Open Access Journals (Sweden)

    Daphne Rickson

    2014-12-01

    Full Text Available This article presents findings from qualitative research which aimed to capture the experience and views of people who were supporting fourteen learners with intellectual disabilities (aged 12-18 to perform with a professional orchestra. Findings have been analysed in two stages. The first analysis, published elsewhere (Rickson 2012, focused on supporters’ experiences of organising and preparing for the performance. The supporters believed that through practising and performing an orchestral work the diverse musicians had the potential to challenge stereotyped portrayals of disability, change attitudes and foster the ongoing inclusion of people with diverse abilities. However, while the learners’ responses during preparatory workshops were described as interesting, meaningful and creative, there seemed to be a general perception that they were vulnerable and in need of protection from potentially unsympathetic audiences. This dichotomy was examined in post-performance interviews with supporters and audience members. Findings, presented here, show that the narrative of vulnerability and ‘overcoming’ persisted. Nevertheless, interviewees remained convinced of the artistic value of the work and believed the learners had the potential to attract wider audiences to their performances. Further opportunities for young people with intellectual disabilities to be involved in community arts projects alongside non-disabled musicians may result.

  9. Spotlight on Brain Tumors: Do You Know the Symptoms?

    Science.gov (United States)

    ... or convulsions) Nausea and vomiting Changes in speech, vision, or hearing Problems balancing or walking Changes in your mood, personality, or ability to concentrate Problems with memory Numbness, tingling, or weakness in the arms or ...

  10. Gamma rays spotlight a dark horse for dark matter

    CERN Multimedia

    Seife, C

    2004-01-01

    "Do mysterious gamma rays emanating from the center of the galaxy hold the secret to the missing matter in the universe? A team of physicists suggests that they might. The controversial finding also shows how little is known about most of the mass in the cosmos"(1/2 page)

  11. Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines

    Directory of Open Access Journals (Sweden)

    Ophélia Le Thuc

    2017-08-01

    Full Text Available The hypothalamus is a key brain region in the regulation of energy balance as it controls food intake and both energy storage and expenditure through integration of humoral, neural, and nutrient-related signals and cues. Many years of research have focused on the regulation of energy balance by hypothalamic neurons, but the most recent findings suggest that neurons and glial cells, such as microglia and astrocytes, in the hypothalamus actually orchestrate together several metabolic functions. Because glial cells have been described as mediators of inflammatory processes in the brain, the existence of a causal link between hypothalamic inflammation and the deregulations of feeding behavior, leading to involuntary weight loss or obesity for example, has been suggested. Several inflammatory pathways that could impair the hypothalamic control of energy balance have been studied over the years such as, among others, toll-like receptors and canonical cytokines. Yet, less studied so far, chemokines also represent interesting candidates that could link the aforementioned pathways and the activity of hypothalamic neurons. Indeed, chemokines, in addition to their role in attracting immune cells to the inflamed site, have been suggested to be capable of neuromodulation. Thus, they could disrupt cellular activity together with synthesis and/or secretion of multiple neurotransmitters/mediators involved in the maintenance of energy balance. This review discusses the different inflammatory pathways that have been identified so far in the hypothalamus in the context of feeding behavior and body weight control impairments, with a particular focus on chemokines signaling that opens a new avenue in the understanding of the major role played by inflammation in obesity.

  12. A framework for planning right of way development : research spotlight.

    Science.gov (United States)

    2013-08-01

    Roadside rights of way serve a wide range of societal, economic and : environmental functions. While these functions traditionally include : providing space for transportation infrastructure, utilities and drainage, : Michigan and many other states a...

  13. Cosmology and Prehistory: Imagination on the Rise. Spotlight: Montessori Potpourri.

    Science.gov (United States)

    Hallenberg, Harvey

    2001-01-01

    Presents the Maori cosmological perspective and the modern theory of evolution. Explains how these two creation stories can coexist. Discusses life on earth during its first 3 billion years, including concepts of singularity, Big Bang, time, space, matter, gravity, stars, planets, seas, and life. (DLH)

  14. Spotlight on ixazomib: potential in the treatment of multiple myeloma

    Directory of Open Access Journals (Sweden)

    Muz B

    2016-01-01

    Full Text Available Barbara Muz,1 Rachel Nicole Ghazarian,1,2 Monica Ou,1,3 Micah John Luderer,1 Hubert Daniel Kusdono,1,2 Abdel Kareem Azab1 1Department of Radiation Oncology, Cancer Biology Division, Washington University in St Louis School of Medicine, 2Department of Pharmaceutical and Administrative Sciences, St Louis College of Pharmacy, 3Department of Biology, St Louis University, St Louis, MO, USA Abstract: Despite the significant therapeutic advances achieved with proteasome inhibitors (PIs such as bortezomib and carfilzomib in prolonging the survival of patients with multiple myeloma, the development of drug resistance, peripheral neuropathy, and pharmacokinetic limitations continue to pose major challenges when using these compounds. Ixazomib is a second-generation PI with improved activity over other PIs. Unlike bortezomib and carfilzomib, which are administered by injection, ixazomib is the first oral PI approved by US Food and Drug Administration. This review discusses the biochemical properties, mechanisms of action, preclinical efficacy, and clinical trial results leading to the US Food and Drug Administration approval of ixazomib. Keywords: proteasome inhibitor, oral administration, biological mechanism, clinical trials

  15. Accelerating bridge construction to minimize traffic disruption : research spotlight.

    Science.gov (United States)

    2013-12-01

    Since 2008, MDOT has been using accelerated bridge construction, which utilizes prefabricated components and structural placements, to minimize traffic disruptions during bridge replacement or rehabilitation. A recent project provided MDOT with a new...

  16. Grantee Spotlight: Elisa Rodriguez, Ph.D., M.S.

    Science.gov (United States)

    Dr. Elisa M. Rodriguez tests the feasibility of community-based participatory research approaches to engaging Hispanics, African Americans, and the medically underserved in the Buffalo, NY area in biospecimen donation for cancer research.

  17. Abuses of sugar market in Latvia, Estonia under spotlight

    Index Scriptorium Estoniae

    2004-01-01

    Läti konkurentsiamet sulges hindade mõjutamise tõttu riigi suuruselt teise suhkruvabriku. Eestit trahvitakse suhkru varumise eest enne Euroopa Liitu astumist. Leedus on aga suhkru tarbimine langenud

  18. Money, money, money [spotlight on financial activity in India

    International Nuclear Information System (INIS)

    Sahai, I.M.

    1998-01-01

    India, with its long history of and vast potential for hydroelectric power, seems set to prioritise this form of power generation, by encouraging private investment in the hydroelectric power through financial incentives. The main reason for the lack of development of the country''s hydro potential is a paucity of financial resources and consequent tardy investment in the hydropower sector, because of the slow rate of return to investors. Government pressure and an expected announcement about policy on hydropower has led to new initiatives to fund new hydroelectric power plants and refurbish the older ones. (UK)

  19. Spotlight on advances in VTE management: CALLISTO and EINSTEIN CHOICE.

    Science.gov (United States)

    Bach, Miriam; Bauersachs, Rupert

    2016-09-28

    Venous thromboembolism (VTE) is associated with numerous complications and high mortality rates. Patients with cancer are at high risk of developing cancer-associated thrombosis (CAT), and VTE recurrence is common. Evidence supporting use of non-vitamin K antagonist (VKA) oral anticoagulants (NOACs) in patients with cancer is lacking - direct comparisons between NOACs and low-molecular-weight heparin (LMWH) are needed, along with patient-reported outcomes. Cancer Associated thrombosis - expLoring soLutions for patients through Treatment and Prevention with RivarOxaban (CALLISTO) is an international research programme exploring the potential of the direct, oral factor Xa inhibitor rivaroxaban for the prevention and treatment of CAT, supplementing existing data from EINSTEIN DVT and EINSTEIN PE. Here, we focus on four CALLISTO studies: A Study to Evaluate the Efficacy and Safety of Rivaroxaban Venous Thromboembolism Prophylaxis in Ambulatory Cancer Participants receiving Chemotherapy (CASSINI), Anticoagulation Therapy in SELECTeD Cancer Patients at Risk of Recurrence of Venous Thromboembolism (SELECT-D), Rivaroxaban in the Treatment of Venous Thromboembolism in Cancer Patients - a Randomized Phase III Study (CONKO-011) and a database analysis. Optimal anticoagulation duration for VTE treatment has always been unclear. Following favourable results for rivaroxaban 20 mg once-daily (Q. D.) for secondary VTE prevention (EINSTEIN EXT), EINSTEIN CHOICE is assessing rivaroxaban safety and (20 mg Q. D. or 10 mg Q. D.) vs acetylsalicylic acid (ASA), and will investigate whether an alternative rivaroxaban dose (10 mg Q. D.) could offer long-term VTE protection. It is anticipated that results from these studies will provide important answers and expand upon current evidence for rivaroxaban in VTE management.

  20. Nutrition in the spotlight: metabolic effects of environmental light

    NARCIS (Netherlands)

    Versteeg, Ruth I.; Stenvers, Dirk J.; Kalsbeek, Andries; Bisschop, Peter H.; Serlie, Mireille J.; la Fleur, Susanne E.

    2016-01-01

    Use of artificial light resulted in relative independence from the natural light-dark (LD) cycle, allowing human subjects to shift the timing of food intake and work to convenient times. However, the increase in artificial light exposure parallels the increase in obesity prevalence. Light is the

  1. Nutrition in the spotlight metabolic effects of environmental light

    NARCIS (Netherlands)

    Versteeg, Ruth I; Stenvers, Dirk J; Kalsbeek, A.; Bisschop, Peter H; Serlie, Mireille J; la Fleur, Susanne E

    2016-01-01

    Use of artificial light resulted in relative independence from the natural light-dark (LD) cycle, allowing human subjects to shift the timing of food intake and work to convenient times. However, the increase in artificial light exposure parallels the increase in obesity prevalence. Light is the

  2. Monitoring highway assets using remote sensing technology : research spotlight.

    Science.gov (United States)

    2014-04-01

    Collecting inventory data about roadway assets is a critical part of : MDOTs asset management efforts, which help the department operate, : maintain and upgrade these assets cost-effectively. Federal law requires : that states develop a risk-based...

  3. New bridge design promises to lengthen service life : research spotlight.

    Science.gov (United States)

    2015-03-01

    In Michigans winter climate, the steel reinforcements in traditional boxbeam : bridges are susceptible to concrete cracking, deterioration and : corrosion. They are also difficult to inspect. To address these problems, : MDOT has partnered with Io...

  4. CERN in the spotlight at the Geneva Festival

    CERN Multimedia

    2004-01-01

    CERN will be the guest of honour at the Geneva Festival, which takes place from 29 July to 8 August. The Organization will be involved in two big events: the curtain-raising firework display and the end-of-festival concert. Come and see the creation of the Universe... acted out by fireworks! CERN, celebrating its 50th anniversary, will raise the curtain on the annual Geneva Festival (Fêtes de Genève) on Friday 30 July at 10.15 p.m. with a pyrotechnical and musical extravaganza. The display will be accompanied by a narration explaining the different stages of creation, written by CERN physicist Rolf Landua. Pyro-musical design is by Catherine Walder, overall firework design by René Gousset and pyrotechnical design by Pierre-Alain Beretta (Pyrostars). For further information see: www.cern.ch/cern50/events/Fireworks/Fireworks-en.html. At the end of the Festival, the CERN choir, itself celebrating its thirtieth year, joins forces with the Annecy choir Pro Musica to give a special performance of Jo...

  5. Spotlight on topographical pressure pain sensitivity maps: a review

    Directory of Open Access Journals (Sweden)

    Alburquerque-Sendín F

    2018-01-01

    Full Text Available Francisco Alburquerque-Sendín,1 Pascal Madeleine,2 César Fernández-de-las-Peñas,3 Paula Rezende Camargo,4 Tania Fátima Salvini4 1Department of Socio-Sanitary Sciences, Radiology and Physical Medicine, Universidad de Córdoba, Córdoba, Spain; 2Physical Activity and Human Performance Group, SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark; 3Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos, Madrid, Spain; 4Department of Physical Therapy, Federal University of São Carlos, São Carlos, SP, Brazil Abstract: Mechanical hyperalgesia defined as decreased pressure pain thresholds (PPTs is commonly associated with pain. In this narrative review, we report the current state of the art within topographical pressure sensitivity maps. Such maps are based on multiple PPT assessments. The PPTs are assessed by an a priori defined grid with special focus on both spatial and temporal summation issues. The grid covers the muscle or the body region of interest using absolute or relative values determined from anatomical landmarks or anthropometric values. The collected PPTs are interpolated by Shepard or Franke and Nielson interpolation methods to create topographical pressure sensitivity maps. This new imaging technique has proven to be valuable in various disciplines including exercise physiology, neurology, physical therapy, occupational medicine, oncology, orthopedics, and sport sciences. The reviewed papers have targeted different body regions like the scalp, low back, neck–shoulder, and upper and lower extremities. The maps have delineated spatial heterogeneity in the pressure pain sensitivity underlining the different extents of pressure pain hyperalgesia in both experimentally induced and disease-associated pain conditions. Furthermore, various intervention studies have proven the utility of topographical pressure pain sensitivity maps. Topographical pressure pain sensitivity maps have contributed to revealing the efficacy of therapeutic, ergonomic, or training interventions that aim at reducing pain. Keywords: pressure pain, topographical, muscle, musculo-tendinous, hyperalgesia

  6. Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis

    Science.gov (United States)

    Mora, Ana L.; Rojas, Mauricio

    2017-01-01

    Idiopathic pulmonary fibrosis (IPF) is a chronic age-related lung disease with high mortality that is characterized by abnormal scarring of the lung parenchyma. There has been a recent attempt to define the age-associated changes predisposing individuals to develop IPF. Age-related perturbations that are increasingly found in epithelial cells and fibroblasts from IPF lungs compared with age-matched cells from normal lungs include defective autophagy, telomere attrition, altered proteostasis, and cell senescence. These divergent processes seem to converge in mitochondrial dysfunction and metabolic distress, which potentiate maladaptation to stress and susceptibility to age-related diseases such as IPF. Therapeutic approaches that target aging processes may be beneficial for halting the progression of disease and improving quality of life in IPF patients. PMID:28145905

  7. Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal

    Directory of Open Access Journals (Sweden)

    Juliana F. de Souza

    2017-03-01

    Full Text Available The behavior of lyotropic biomimetic systems in drug delivery was reviewed. These behaviors are influenced by drug properties, the initial water content, type of lyotropic liquid crystals (LLC, swell ability, drug loading rate, the presence of ions with higher or less kosmotropic or chaotropic force, and the electrostatic interaction between the drug and the lipid bilayers. The in vivo interaction between LCC—drugs, and the impact on the bioavailability of drugs, was reviewed. The LLC with a different architecture can be formed by the self-assembly of lipids in aqueous medium, and can be tuned by the structures and physical properties of the emulsion. These LLC lamellar phase, cubic phase, and hexagonal phase, possess fascinating viscoelastic properties, which make them useful as a dispersion technology, and a highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix for drug delivery. In addition, the biodegradable and biocompatible nature of lipids demonstrates a minimum toxicity and thus, they are used for various routes of administration. This review is not intended to provide a comprehensive overview, but focuses on the advantages over non modified conventional materials and LLC biomimetic properties.

  8. Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal.

    Science.gov (United States)

    de Souza, Juliana F; Pontes, Katiusca da S; Alves, Thais F R; Amaral, Venâncio A; Rebelo, Márcia de A; Hausen, Moema A; Chaud, Marco V

    2017-03-07

    The behavior of lyotropic biomimetic systems in drug delivery was reviewed. These behaviors are influenced by drug properties, the initial water content, type of lyotropic liquid crystals (LLC), swell ability, drug loading rate, the presence of ions with higher or less kosmotropic or chaotropic force, and the electrostatic interaction between the drug and the lipid bilayers. The in vivo interaction between LCC-drugs, and the impact on the bioavailability of drugs, was reviewed. The LLC with a different architecture can be formed by the self-assembly of lipids in aqueous medium, and can be tuned by the structures and physical properties of the emulsion. These LLC lamellar phase, cubic phase, and hexagonal phase, possess fascinating viscoelastic properties, which make them useful as a dispersion technology, and a highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix for drug delivery. In addition, the biodegradable and biocompatible nature of lipids demonstrates a minimum toxicity and thus, they are used for various routes of administration. This review is not intended to provide a comprehensive overview, but focuses on the advantages over non modified conventional materials and LLC biomimetic properties.

  9. Teratozoospermia: spotlight on the main genetic actors in the human.

    Science.gov (United States)

    Coutton, Charles; Escoffier, Jessica; Martinez, Guillaume; Arnoult, Christophe; Ray, Pierre F

    2015-01-01

    Male infertility affects >20 million men worldwide and represents a major health concern. Although multifactorial, male infertility has a strong genetic basis which has so far not been extensively studied. Recent studies of consanguineous families and of small cohorts of phenotypically homogeneous patients have however allowed the identification of a number of autosomal recessive causes of teratozoospermia. Homozygous mutations of aurora kinase C (AURKC) were first described to be responsible for most cases of macrozoospermia. Other genes defects have later been identified in spermatogenesis associated 16 (SPATA16) and dpy-19-like 2 (DPY19L2) in patients with globozoospermia and more recently in dynein, axonemal, heavy chain 1 (DNAH1) in a heterogeneous group of patients presenting with flagellar abnormalities previously described as dysplasia of the fibrous sheath or short/stump tail syndromes, which we propose to call multiple morphological abnormalities of the flagella (MMAF). A comprehensive review of the scientific literature available in PubMed/Medline was conducted for studies on human genetics, experimental models and physiopathology related to teratozoospermia in particular globozoospermia, large headed spermatozoa and flagellar abnormalities. The search included all articles with an English abstract available online before September 2014. Molecular studies of numerous unrelated patients with globozoospermia and large-headed spermatozoa confirmed that mutations in DPY19L2 and AURKC are mainly responsible for their respective pathological phenotype. In globozoospermia, the deletion of the totality of the DPY19L2 gene represents ∼ 81% of the pathological alleles but point mutations affecting the protein function have also been described. In macrozoospermia only two recurrent mutations were identified in AURKC, accounting for almost all the pathological alleles, raising the possibility of a putative positive selection of heterozygous individuals. The recent identification of DNAH1 mutations in a proportion of patients with MMAF is promising but emphasizes that this phenotype is genetically heterogeneous. Moreover, the identification of mutations in a dynein strengthens the emerging point of view that MMAF may be a phenotypic variation of the classical forms of primary ciliary dyskinesia. Based on data from human and animal models, the MMAF phenotype seems to be favored by defects directly or indirectly affecting the central pair of axonemal microtubules of the sperm flagella. The studies described here provide valuable information regarding the genetic and molecular defects causing infertility, to improve our understanding of the physiopathology of teratozoospermia while giving a detailed characterization of specific features of spermatogenesis. Furthermore, these findings have a significant influence on the diagnostic strategy for teratozoospermic patients allowing the clinician to provide the patient with informed genetic counseling, to adopt the best course of treatment and to develop personalized medicine directly targeting the defective gene products. © The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  10. Spotlight on the perioperative use of maropitant citrate

    Directory of Open Access Journals (Sweden)

    Hay Kraus BL

    2017-08-01

    Full Text Available Bonnie L Hay Kraus Department of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA Abstract: Neurokinin-1 (NK-1 receptors are present in both the central nervous system and peripheral tissues. Substance P (SP is the major ligand and is involved in multiple processes including pain transmission, vasodilation, modulation of the inflammatory response, as well as the sensory neuronal transmission involved in stress, anxiety, and emesis. The involvement of NK-1 and SP in the vomiting reflex has led to the development of NK-1 antagonists to prevent and treat vomiting in human and veterinary medicine. Maropitant is a potent, selective neurokinin (NK-1 receptor antagonist that blocks the pharmacologic action of SP in the central nervous system. Maropitant is available in both an injectable and tablet formulation and approved for use in dogs and cats for the treatment and prevention of vomiting from a variety of clinical causes and motion sickness. When administered prior to anesthetic premedication, maropitant prevents or significantly decreases the incidence of opioid-induced vomiting and signs of nausea in dogs and cats. Maropitant has also been shown to improve postoperative return to feeding and food intake in dogs. The minimum alveolar concentration of sevoflurage is decreased in both dogs and cats by maropitant, indicating a potential role as an adjunct analgesic, especially for visceral pain. This article will review the background information and literature, including clinical recommendations with respect to the perioperative use of maropitant in canine and feline veterinary patients. Keywords: maropitant, perioperative nausea and vomiting, neurokinin-1 antagonist, Substance P

  11. The 2015 Five-yearly review: diversity in the spotlight

    CERN Document Server

    Staff Association

    2014-01-01

    Introduction As mentioned in Echo 201, with the Council Decision of last June the CERN 2015 five-yearly review has formally begun. Following the procedure defined in Annex A1 of the Staff Rules and Regulations CERN will thus review its financial and social conditions that should enable it to recruit from all its Member States, and retain, staff of the highest competence and integrity necessary to perform its mission. In addition, these conditions should increase the attractiveness of CERN in all Member States and motivate staff of all ages and all occupations throughout their careers. Annex A1 stipulates that a five-yearly review must include basic salaries (stipends for Fellows and subsistence allowances for associated members of the personnel) and, optionally, may include any other financial or social conditions. For this optional part of the 2015 exercise, the CERN career structure and measures to improve diversity were chosen. Towards a better diversity policy The analysis of the 2013 Staff Associat...

  12. Grandparenting--A Montessori Way. Spotlight: Updating Our Agendas.

    Science.gov (United States)

    Borgholthaus, Page

    2002-01-01

    Defines the grandmother-grandchild relationship in light of Montessori theory, focusing on the prepared environment. Recommends having bookshelves for the grandparents' collection of their own favorite children's books, arranging puzzles and other manipulatives around the house, adapting home tasks to include the child, sharing meaningful time…

  13. The Essence of Montessori. Spotlight: Updating Our Agendas.

    Science.gov (United States)

    Loeffler, Margaret H.

    2002-01-01

    Discusses the essential elements of Montessori educational philosophy and theory, focusing on the integration, development, and maintenance of the four characteristics of normalization (concentration, work, discipline, sociability) into adulthood. Discusses Montessori's view that development and retention of these positive characteristics could be…

  14. Spotlight on dream recall: the ages of dreams

    Science.gov (United States)

    Mangiaruga, Anastasia; Scarpelli, Serena; Bartolacci, Chiara; De Gennaro, Luigi

    2018-01-01

    Brain and sleep maturation covary across different stages of life. At the same time, dream generation and dream recall are intrinsically dependent on the development of neural systems. The aim of this paper is to review the existing studies about dreaming in infancy, adulthood, and the elderly stage of life, assessing whether dream mentation may reflect changes of the underlying cerebral activity and cognitive processes. It should be mentioned that some evidence from childhood investigations, albeit still weak and contrasting, revealed a certain correlation between cognitive skills and specific features of dream reports. In this respect, infantile amnesia, confabulatory reports, dream-reality discerning, and limitation in language production and emotional comprehension should be considered as important confounding factors. Differently, growing evidence in adults suggests that the neurophysiological mechanisms underlying the encoding and retrieval of episodic memories may remain the same across different states of consciousness. More directly, some studies on adults point to shared neural mechanisms between waking cognition and corresponding dream features. A general decline in the dream recall frequency is commonly reported in the elderly, and it is explained in terms of a diminished interest in dreaming and in its emotional salience. Although empirical evidence is not yet available, an alternative hypothesis associates this reduction to an age-related cognitive decline. The state of the art of the existing knowledge is partially due to the variety of methods used to investigate dream experience. Very few studies in elderly and no investigations in childhood have been performed to understand whether dream recall is related to specific electrophysiological pattern at different ages. Most of all, the lack of longitudinal psychophysiological studies seems to be the main issue. As a main message, we suggest that future longitudinal studies should collect dream reports upon awakening from different sleep states and include neurobiological measures with cognitive performances. PMID:29391838

  15. Spotlight on dream recall: the ages of dreams.

    Science.gov (United States)

    Mangiaruga, Anastasia; Scarpelli, Serena; Bartolacci, Chiara; De Gennaro, Luigi

    2018-01-01

    Brain and sleep maturation covary across different stages of life. At the same time, dream generation and dream recall are intrinsically dependent on the development of neural systems. The aim of this paper is to review the existing studies about dreaming in infancy, adulthood, and the elderly stage of life, assessing whether dream mentation may reflect changes of the underlying cerebral activity and cognitive processes. It should be mentioned that some evidence from childhood investigations, albeit still weak and contrasting, revealed a certain correlation between cognitive skills and specific features of dream reports. In this respect, infantile amnesia, confabulatory reports, dream-reality discerning, and limitation in language production and emotional comprehension should be considered as important confounding factors. Differently, growing evidence in adults suggests that the neurophysiological mechanisms underlying the encoding and retrieval of episodic memories may remain the same across different states of consciousness. More directly, some studies on adults point to shared neural mechanisms between waking cognition and corresponding dream features. A general decline in the dream recall frequency is commonly reported in the elderly, and it is explained in terms of a diminished interest in dreaming and in its emotional salience. Although empirical evidence is not yet available, an alternative hypothesis associates this reduction to an age-related cognitive decline. The state of the art of the existing knowledge is partially due to the variety of methods used to investigate dream experience. Very few studies in elderly and no investigations in childhood have been performed to understand whether dream recall is related to specific electrophysiological pattern at different ages. Most of all, the lack of longitudinal psychophysiological studies seems to be the main issue. As a main message, we suggest that future longitudinal studies should collect dream reports upon awakening from different sleep states and include neurobiological measures with cognitive performances.

  16. University of Florida potato variety trials spotlight: 'Peter Wilcox'

    Science.gov (United States)

    'Peter Wilcox’ is a fresh market potato variety selected from progeny of a cross between B0810-1 and B0918-5, and tested under the pedigree B1816-5 by K.G. Haynes. It was jointly released by United States Department of Agriculture, North Carolina Agricultural Research Service, Agricultural Experimen...

  17. University of Florida potato variety trials spotlight: 'Harley Blackwell'

    Science.gov (United States)

    ‘Harley Blackwell’ is a potato variety that is commonly grown for the potato chip market. It was selected from the progeny of a cross between B0155-24 and B9935-8, and tested under the pedigree B0564-8. It was released and named jointly by the Agricultural Research Service, United States Department ...

  18. Spotlight on the Diagnosis of Acute Promyelocytic Leukemia (AML ...

    African Journals Online (AJOL)

    QR-RT-PCR demonstrated bcr1 positivity in the 4 patients diagnosed by Karyotyping with t (15;17) and in the 8 patients can not diagnosed by Cytogenetic methods. Conclusion: Despite the fact that cytogenetics permit the identification of many chromosomal changes within a sample, FISH analysis is more sensitive when ...

  19. Web-Based Family Life Education: Spotlight on User Experience

    Science.gov (United States)

    Doty, Jennifer; Doty, Matthew; Dwrokin, Jodi

    2011-01-01

    Family Life Education (FLE) websites can benefit from the field of user experience, which makes technology easy to use. A heuristic evaluation of five FLE sites was performed using Neilson's heuristics, guidelines for making sites user friendly. Greater site complexity resulted in more potential user problems. Sites most frequently had problems…

  20. Pediatric Celiac Disease: Follow-Up in the Spotlight.

    Science.gov (United States)

    Valitutti, Francesco; Trovato, Chiara Maria; Montuori, Monica; Cucchiara, Salvatore

    2017-03-01

    The follow-up of celiac disease (CD) is challenging due to the scarcity of published data and the lack of standardized evidence-based protocols. The worldwide frequency and methods of CD follow-up appear to be heavily influenced by expert opinions of the individual physicians who assess children with CD. The aim of this review was to summarize the available studies on CD follow-up in children. We conducted a literature search with the use of PubMed, Medline, and Embase (from 1900 to 15 December 2016) for terms relevant to this review, including CD, follow-up, dietary adherence or dietary compliance, nutrition, comorbidities, complications, and quality of life. The aims of follow-up are as follows: to ensure strict adherence to a gluten-free diet, to ensure nutritional adequacy, to improve quality of life, and to prevent disease complications. For the correct evaluation of children with CD at follow-up, a clinical and biochemical evaluation is necessary on a regular basis. It is advisable to assess compliance, nutrition, comorbidities, or possible complications once a year at the referral center. Laboratory tests might be useful for a thorough evaluation of any patient with CD to rule out a micronutrient deficiency (full blood count, ferritin, folic acid, vitamin B-6, and vitamin B-12) and possible cardiovascular risk factors (glucose, LDL cholesterol, triglycerides). Biochemical evaluation is essential when there are clinical problems and should be customized on the basis of the specific clinical suspicion. Associated autoimmune thyroiditis should also be screened for yearly by measuring thyroid-stimulating hormone and thyroid autoantibody concentrations, regardless of symptoms, because hypothyroidism is often subtle and methods for early treatment are available and desirable. Although evidence-based recommendations for follow-up of pediatric patients with CD have not yet been established, we advise a yearly follow-up visit as the safest approach. © 2017 American Society for Nutrition.

  1. Spotlight on Ethics: Institutional Review Boards as Systemic Bullies

    Science.gov (United States)

    Carr, Caleb T.

    2015-01-01

    Bullying, often considered an interpersonal or intergroup behaviour, has not been explored as an unintended artefact of organisational structure. Institutional review boards (IRBs), the 'human research ethics committees' at US universities, help oversee the protection of human research subjects, particularly in the social sciences within…

  2. Fisheries management worldwide has been under the spotlight in ...

    African Journals Online (AJOL)

    denise

    and bag limits) for both recreational and commercial linefish species were introduced in December 1984. Since then, some new regulations have been added, whereas others have been amended as new evidence on the biology of individual species has come to light. The failure of these conventional fishery control mea-.

  3. THE BRICS IN THE SPOTLIGHT: A RESEARCH AGENDA

    Directory of Open Access Journals (Sweden)

    L. Scaffardi

    2014-01-01

    Full Text Available On November 6–7, 2014, the University of Parma (Italy hosted a profound two-day discussion on the BRICS, i.e. Brazil, Russia, India, China and South Africa, a relatively new actor in the international arena, gathering the most innovative research and the leading experts and scholars.

  4. Software offers transparent, straightforward assessment of pavement additives : research spotlight.

    Science.gov (United States)

    2015-04-01

    Adding new materials to pavement layers is a proven technique to : improve performance. Many types of additivesfrom engineered : polymers and acids to recycled pavement, crumb rubber, shingles : and glasshave been used to help construct better ...

  5. Aging, metabolism and stem cells: Spotlight on muscle stem cells.

    Science.gov (United States)

    García-Prat, Laura; Muñoz-Cánoves, Pura

    2017-04-15

    All tissues and organs undergo a progressive regenerative decline as they age. This decline has been mainly attributed to loss of stem cell number and/or function, and both stem cell-intrinsic changes and alterations in local niches and/or systemic environment over time are known to contribute to the stem cell aging phenotype. Advancing in the molecular understanding of the deterioration of stem cell cells with aging is key for targeting the specific causes of tissue regenerative dysfunction at advanced stages of life. Here, we revise exciting recent findings on why stem cells age and the consequences on tissue regeneration, with a special focus on regeneration of skeletal muscle. We also highlight newly identified common molecular pathways affecting diverse types of aging stem cells, such as altered proteostasis, metabolism, or senescence entry, and discuss the questions raised by these findings. Finally, we comment on emerging stem cell rejuvenation strategies, principally emanating from studies on muscle stem cells, which will surely burst tissue regeneration research for future benefit of the increasing human aging population. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. The EU-NATO Syndrome: Spotlight on Transatlantic Realities

    Directory of Open Access Journals (Sweden)

    Hajnalka Vincze

    2007-09-01

    Full Text Available This article examines the relations between the European Union (EU and NATO in light of both of the current, deeply unhealthy, state of the transatlantic relationship, and of its ongoing evolution. The first part is devoted to a retrospective outline of the links between European defence and the Atlantic system, which highlights the major constant features of these last sixty years, as well as the rupture points. Then, various issues, from the problem of the division of labour and the definition of the chain of command to coordination on the ground and arms procurement, are evoked as concrete examples where the same fundamental question marks emerge, again and again; all of them revolving around the concept of sovereignty – that of the Europeans vis-à-vis America. It is suggested in the article that current European dependence does not allow but superficial and/or temporary ‘progress’ in EU-NATO relations, just as is the case in the broader Euro-American relationship. As long as Europeans will not assume fully the objective of autonomy (i.e. freedom of decision and action, with all the commitments it would imply, their subjection will continue to generate increasing tensions, since this inherent imbalance is not only detrimental to Europe’s own interests, but it also excludes any reciprocity and prohibits any genuine partnership with the United States.

  7. Research Spotlight: New method to assess coral reef health

    Science.gov (United States)

    Tretkoff, Ernie

    2011-03-01

    Coral reefs around the world are becoming stressed due to rising temperatures, ocean acidification, overfishing, and other factors. Measuring community level rates of photosynthesis, respiration, and biogenic calcification is essential to assessing the health of coral reef ecosystems because the balance between these processes determines the potential for reef growth and the export of carbon. Measurements of biological productivity have typically been made by tracing changes in dissolved oxygen in seawater as it passes over a reef. However, this is a labor-intensive and difficult method, requiring repeated measurements. (Geophysical Research Letters, doi:10.1029/2010GL046179, 2011)

  8. PARTICLE FACTORIES: Tau-charm in the spotlight

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Following earlier workshops in Stanford (1989) and in Orsay (1990), some hundred physicists from Europe and the United States met from 29 April to 2 May in Seville, Spain, to consolidate plans for a Tau-Charm Factory

  9. Comprehensive guidance for pedestrian and bicycle safety improvements : Research Spotlight

    Science.gov (United States)

    2012-01-01

    Planners and designers at every level of government look for ways to make Michigan roads safer for pedestrians and bicyclists. A wide range of improvement options at intersections and along corridors offers the potential for safer streets. MDOT under...

  10. A THEORETICAL SPOTLIGHT OVER THE ROMANIAN AGRICULTURAL PRODUCTS

    Directory of Open Access Journals (Sweden)

    Tarcza Teodora

    2012-07-01

    Full Text Available This paper aims at identifying and classifying new types of agricultural products, especially in Romania, but not only. As we well know, all the countries all over the world have their own history, traditions, economic structure, and a certain type of agriculture, adapted to their soil, climate, and nevertheless to theirs people needs. So, we know that certain countries used to cultivate certain agricultural products, while others are wellknown for others. Usually, we associate Spain with great wines, Belgium with delicious chocolate, Turkey with coffee, India with rice, Romania with grain, Russia with cereals, SUA – tobacco, etc.\\r\

  11. Research Spotlight: Identifying oceanic sources of continental precipitation

    Science.gov (United States)

    Ofori, Leslie; Tretkoff, Ernie

    Ninety percent of water that evaporates from the oceans precipitates back to the oceans. The remaining 10% is transported to the continents and plays an important role in the land branch of the hydrological cycle. Studies have suggested that rising global temperatures will lead to increased evaporation and precipitation, altering the hydrological cycle. To identify regions that will be vulnerable to these changes in the hydrological cycle, Gimeno et al. used a model to detect major oceanic moisture source areas and the continental regions significantly influenced by each moisture source.

  12. INCIDENCIA ECONÓMICA, CULTURAL Y TURÍSTICA, EN LAS NECESIDADES INSATISFECHAS DE LA COMUNA SAN PABLO CANTÓN SANTA ELENA, PROVINCIA SANTA ELENA AÑO 2015

    Directory of Open Access Journals (Sweden)

    Karina Isabel Bricio Samaniego

    2016-12-01

    Full Text Available Resumen La presente investigación tiene como objetivo principal analizar los aspectos: culturales, económicos, y turísticos de la comuna San Pablo, que permita identificar las necesidades insatisfechas en la Comuna, en la actualidad está compuesta por la zona económica que se encuentra conformada por negocios comerciales de diferentes productos o servicios, la zona empresarial conformada por numerosos laboratorios de crianza de larvas de camarón, empresas industriales pesqueras, nuevos negocios o microempresas familiares de diversas actividades económicas o productivas. Para la elaboración de este trabajo se utilizó la metodología basada en investigación cuantitativa y cualitativa. Se describió las características generales de la problemática existente, permitiendo elaborar una diagnostico situacional de tipo integral, identificando los programas, proyectos y acciones que van a ser evaluados mediante indicadores de gestión de eficiencia, y eficacia, con la implementación de estrategias como son los convenios con las instituciones del estado, capacitación a los directivos para realizar una eficiente administración comunal, buen trabajo en equipo, ejecución de programas y proyectos, participación oportuna de los habitantes para el logro de un crecimiento permanente para la comuna, sus organizaciones y asociaciones ubicadas dentro de su territorio. Palabras clave: Aspectos económicos, sociales, culturales, Comunas, desarrollo turístico Abstract he present investigation has as main objective to analyze the aspects: cultural, economic, and tourist of the commune San Pablo that allows to identify the unsatisfied necessities in the Commune, at the present time is composed by the economic area that is confirmed by commercial business of different products or services, the managerial area conformed by numerous laboratories of upbringing of shrimp larva’s, companies industrial fishing and new business or family microempresas of diverse economic or productive activities. For the elaboration of this work the methodology was used based on quantitative and qualitative investigation. It was described the general characteristics of the existent problem, allowing to elaborate one diagnoses situational of integral type, identifying the programs, projects and actions that will be evaluated by means of indicators of administration of efficiency, and effectiveness, with the implementation of strategies like they are the agreements with the institutions of the state, training the directive to carry out an efficient administration communal, good work in team, execution of programs and projects, the inhabitants' opportune participation for the achievement of a permanent growth for the commune, their organizations and associations located inside their territory. Words key: Economic, social, cultural aspects, Communes, tourist developmen

  13. Rahvaste vanglast rahvaste ühisesse perre? : Habsburgide monarhiast slovakkide rahvuslikus mälus / Elena Mannova ; tlk. Mati Laur

    Index Scriptorium Estoniae

    Mannova, Elena

    2006-01-01

    Slovakkia ajalookirjutust alates 1918. aastast kuni tänapäevani mõjutanud rahvusmütoloogiast. Suhtumisest Austria-Ungari kaksikriiki ja Habsburgide dünastiasse ning rahvuslike kannatuste e. orjapõlve müüdi modelleerumisest historiograafias

  14. Pedagogia de la Participacion: Entering Elena Garro's "Un hogar solido" through the Body. Enacting Death and Politics in Mexico

    Science.gov (United States)

    Misemer, Sarah M.

    2009-01-01

    Garro's one-act play offers an unusual combination of corpses and animate actors on stage thus combining life and death in the same body. Garro's piece presents students with an approach to "embodying" Mexican culture and its notions of death. The fusion of death and cultural practices in Mexico is a crucial part of the ongoing project for…

  15. Greetings from the Border : World War I in Letters of Russian Soldiers Stationed in Finland / Elena Dubrovskaya

    Index Scriptorium Estoniae

    Dubrovskaya, Elena, 1960-

    2004-01-01

    Soomlaste ja vene sõjaväelaste vaheliste suhete pingestumisest alates 1880ndatest. Esimese maailmasõja ajal Soome suurvürstiriigi territooriumil paiknenud vene sõdurite kirjadest ja vene tsensorite aruannetest soomlaste meelsuse kohta

  16. A.L. SOKOVNIN’S PIANO SCHOOL. ELENA RESHETNICHENKO — SOME TRAITS OF THE CREATIVE PORTRAIT

    Directory of Open Access Journals (Sweden)

    MELNIC TAMARA

    2017-06-01

    Full Text Available This article is dedicated to the memory of E. Reshetnicenco — an educator at the General Piano Department, one of the most talented representatives of A. Sokovnin’s piano school. In the creations of romantic composers, which form the basis of the concert repertoire, is captured the figurative and emotional field, the most consonant to the nature of the pianist. At the same time, her interpretations combined an analytical approach to the compositions, a thorough reasoning of details, and disregard of external effects. All these were distinctive features of all Sokovnin’s disciples.

  17. Análisis Estructural de Fallas Geológicas y Potenciales Deslizamientos en Anconcito, Provincia de Santa Elena

    Directory of Open Access Journals (Sweden)

    Kervin Chunga

    2015-10-01

    Los factores que pueden incrementar la tasa de velocidad de deslizamiento de masas de tierra pueden ser: (1 altasprecipitaciones durante el fenómeno del Niño, y (2 la recurrencia de terremotos locales con magnitud moderada Mw≈5 o el arribo de amplificaciones de ondas sísmicas desde terremotos lejanos con magnitudes mayores de Mw>7. En conclusión, el sector de Anconcito debe ser motivo de análisis en detalle que permita establecer técnicas adecuadas para la recuperación de zona de playa y construcción de espigones que permitirán disminuir la alta energía de las ondas marinas.

  18. Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine

    Science.gov (United States)

    Allais, Gianni; Benedetto, Chiara

    2016-01-01

    Migraine is a common neurovascular disorder, affecting millions of people worldwide. Current guidelines recommend triptans as first-line treatment for moderate-to-severe migraine attacks. Frovatriptan is a second-generation triptan with a longer terminal elimination half-life in blood than other triptans (~26 hours). Three double-blind, randomized crossover preference studies have been recently conducted, assessing efficacy and safety of frovatriptan versus rizatriptan, zolmitriptan, and almotriptan, respectively. Frovatriptan showed favorable tolerability and sustained effect, with a significantly lower rate of relapse over 48 hours versus the other triptans. These findings were confirmed in a series of analyses of patient subsets from the three studies, including patients with menstrually related and oral contraceptive-induced migraine, hypertension, obesity, weekend migraine, as well as patients with migraine with aura. In all patient subsets analyzed, lower headache recurrence rates were observed versus the comparator triptans, indicating a more sustained pain-relieving effect on migraine symptoms. A further randomized, double-blind study demonstrated that frovatriptan given in combination with the fast-acting cyclooxygenase inhibitor dexketoprofen provided improved migraine pain-free activity at 2 hours, and gave more sustained pain-free activity at 24 hours, versus frovatriptan alone. These benefits were observed both when the combination was administered early (1 hour after onset). Different pharmacokinetic, but synergistic, properties between frovatriptan and dexketoprofen may make the combination of these agents particularly effective in migraine treatment, with rapid onset of action and sustained effect over 48 hours. These benefits, together with potential cost-effectiveness advantages versus other triptans could drive selection of the most appropriate treatment for acute migraine attacks. PMID:27757013

  19. Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine

    Directory of Open Access Journals (Sweden)

    Allais G

    2016-10-01

    Full Text Available Gianni Allais, Chiara Benedetto Department of Surgical Sciences, Women’s Headache Center, University of Turin, Turin, Italy Abstract: Migraine is a common neurovascular disorder, affecting millions of people worldwide. Current guidelines recommend triptans as first-line treatment for moderate-to-severe migraine attacks. Frovatriptan is a second-generation triptan with a longer terminal elimination half-life in blood than other triptans (~26 hours. Three double-blind, randomized crossover preference studies have been recently conducted, assessing efficacy and safety of frovatriptan versus rizatriptan, zolmitriptan, and almotriptan, respectively. Frovatriptan showed favorable tolerability and sustained effect, with a significantly lower rate of relapse over 48 hours versus the other triptans. These findings were confirmed in a series of analyses of patient subsets from the three studies, including patients with menstrually related and oral contraceptive-induced migraine, hypertension, obesity, weekend migraine, as well as patients with migraine with aura. In all patient subsets analyzed, lower headache recurrence rates were observed versus the comparator triptans, indicating a more sustained pain-relieving effect on migraine symptoms. A further randomized, double-blind study demonstrated that frovatriptan given in combination with the fast-acting cyclooxygenase inhibitor dexketoprofen provided improved migraine pain-free activity at 2 hours, and gave more sustained pain-free activity at 24 hours, versus frovatriptan alone. These benefits were observed both when the combination was administered early (<1 hour after symptom onset or late (>1 hour after onset. Different pharmacokinetic, but synergistic, properties between frovatriptan and dexketoprofen may make the combination of these agents particularly effective in migraine treatment, with rapid onset of action and sustained effect over 48 hours. These benefits, together with potential cost-effectiveness advantages versus other triptans could drive selection of the most appropriate treatment for acute migraine attacks. Keywords: migraine, frovatriptan, menstrual, dexketoprofen, triptans, migraine with aura

  20. Effective Professional Development Programs for Teachers of English Language Learners. Spotlight on Student Success. No. 803

    Science.gov (United States)

    Tellez, Kip; Waxman, Hersh C.

    2005-01-01

    One of our greatest educational challenges continues to be improving the education of English language learners (ELLs). Because many new teachers are underprepared and many veteran teachers wholly unprepared for teaching ELLs, school districts nationwide have initiated professional development programs for inservice teachers. In this article, the…

  1. Cable median barriers : a cost-effective means to save lives : research spotlight.

    Science.gov (United States)

    2014-10-01

    Median-crossover crashes are among the most hazardous events that : can occur on freeways, often leading to serious injury or death. In recent : years, high-tension cable median barriers have emerged as a cost-effective alternative to conventional ba...

  2. Black Achievers' Experiences with Racial Spotlighting and Ignoring in a Predominantly White High School

    Science.gov (United States)

    Carter Andrews, Dorinda J.

    2012-01-01

    Background/Context: Despite a history of racial oppression and degradation in U.S. schools, African Americans have responded to racism and discrimination in ways that promote educational attainment and school success. Many Black adolescents have been empowered to succeed academically partly because of their awareness of racist practices in…

  3. Kinesin moving through the spotlight: Single-motor fluorescence microscopy with submillisecond time resolution

    NARCIS (Netherlands)

    Verbrugge, S.; Kapitein, L.C.; Peterman, E.J.G.

    2007-01-01

    Kinesin-1 is one of the motor proteins that drive intracellular transport in eukaryotes. This motor makes hundreds of 8-nm steps along a microtubule before releasing. Kinesin-1 can move at velocities of up to ∼800 nm/s, which means that one turnover on average takes 10 ms. Important details,

  4. Rasagiline meta-analysis: a spotlight on clinical safety and adverse events when treating Parkinson's disease.

    Science.gov (United States)

    Solís-García del Pozo, Julián; Mínguez-Mínguez, Sara; de Groot, Piet W J; Jordán, Joaquín

    2013-07-01

    Rasagiline (Azilect, AGN 1135) is a selective irreversible inhibitor of monoamine oxidase B (MAO-B). MAO-B regulates the brain concentrations of important neurotransmitters that are related to movement, emotion, and cognition. Oral rasagiline, as monotherapy or as adjunctive therapy to levodopa, was effective in the symptomatic treatment of adult patients with Parkinson's disease participating in double-blind, placebo-controlled, international studies. This article reviews the reported adverse effects of rasagiline. A MEDLINE search was performed for all articles from 1990 to present, which reported any adverse effects from rasagiline or related references. We conducted an analysis of the adverse effects of rasagiline based on the reported clinical studies. Furthermore, we compared the incidence of adverse events in clinical trials for rasagiline and placebo. Among the most frequently reported adverse effects for rasagiline as monotherapy are headache, dizziness, and insomnia. Depression, dizziness, somnolence, and other sleep disorders are reported when used in combination therapy. Our analysis demonstrates that the most frequently reported adverse effects in trials did not occur more often with rasagiline than placebo. In conclusion, rasagiline is a well-tolerated MAO-B inhibitor that may help to achieve the desired level of clinical benefit in Parkinson's disease.

  5. Putting urban soils in the spotlight: A learning experience through the Climate-KIC's initiative

    Science.gov (United States)

    Maymó, Ana; Gimeno-García, Eugenia; Pascual-Aguilar, Juan Antonio; Andreu, Vicente; Rubio, José Luis

    2015-04-01

    The European Commission encourages integrating ecosystem-based approaches in the portfolio of adaptation strategies also in the urban areas. However, the renewed interest in the environmental benefits from green infrastructures coexists with the marginality with which they are treated in practice and, especially, where soil is concerned. Despite its critical functions, soils in cities have often been neglected. In fact, urban soil issues rarely get society attention or even from our policy makers. But, how to make urban soils visible?. From academia we need to extend our communication and networking abilities to engage citizens with projects related to urban soils. Through the Climate-KIC's professional placement programme, Pioneers into Practice, we were able to connect with stakeholders with widely different interests, and engage a broad range of opinions and comments on local circumstances and needs in a semi-quantitative form. Methodology included an actor analysis, an actor network map and a set of semi-structured actor interviews. This involved a local stakeholder network establishment. This stakeholder network reaches out beyond the usual suspects we would expect to partner and it is represented by the following groups: local administration, local governmental services (e.g., forestry and agriculture extension), relevant non-governmental organizations (e.g., dedicated to environment or development) at local level, planners, developers, and individuals (e.g., long-term local residents). The approach is focused on the non-technical barriers to success, whether they are social, institutional, financial, behavioral or regulatory, and how to overcome them. In this context, of a raising environmental awareness, the principal response from interviews demonstrated strong support for a strategic approach to soil management at the urban core and the countryside fringe. Herein, the contribution of urban soils to the provision of ecosystem services, in the framework of the Payments for Ecosystem Services (PES), aroused a great deal of interest among the different stakeholders interviewed. However, the low level of community awareness and understanding of threats to soil natural capital and the long-term consequences of this were also recognized.

  6. Spotlighting a Silent Category of Young Females: The Life Experiences of "House Girls" in Turkey

    Science.gov (United States)

    Celik, Kezban; Lukuslu, Demet

    2012-01-01

    This article examines the everyday life experiences of young women in Turkey known as "ev kizi" or "house girls." The article explores how traditional gender roles and family structure in Turkish society limit their full participation in political, economic, and public life. The study is based on in-depth interviews conducted…

  7. Spotlight on the presenter : a study into presentations of conference papers with PowerPoint

    NARCIS (Netherlands)

    Hertz, B.

    2015-01-01

    Abstract 1. Introduction PowerPoint is the most widely used presentation software tool. As of 2012, PowerPoint had more than 200 million presenters worldwide. Presenters all over the world use the program. Some use it for university teaching, others for business

  8. Spotlight on Speech Codes 2010: The State of Free Speech on Our Nation's Campuses

    Science.gov (United States)

    Foundation for Individual Rights in Education (NJ1), 2010

    2010-01-01

    Each year, the Foundation for Individual Rights in Education (FIRE) conducts a rigorous survey of restrictions on speech at America's colleges and universities. The survey and resulting report explore the extent to which schools are meeting their legal and moral obligations to uphold students' and faculty members' rights to freedom of speech,…

  9. Spotlight on Speech Codes 2011: The State of Free Speech on Our Nation's Campuses

    Science.gov (United States)

    Foundation for Individual Rights in Education (NJ1), 2011

    2011-01-01

    Each year, the Foundation for Individual Rights in Education (FIRE) conducts a rigorous survey of restrictions on speech at America's colleges and universities. The survey and accompanying report explore the extent to which schools are meeting their legal and moral obligations to uphold students' and faculty members' rights to freedom of speech,…

  10. Spotlight on Speech Codes 2009: The State of Free Speech on Our Nation's Campuses

    Science.gov (United States)

    Foundation for Individual Rights in Education (NJ1), 2009

    2009-01-01

    Each year, the Foundation for Individual Rights in Education (FIRE) conducts a wide, detailed survey of restrictions on speech at America's colleges and universities. The survey and resulting report explore the extent to which schools are meeting their obligations to uphold students' and faculty members' rights to freedom of speech, freedom of…

  11. Video Book Trailers: Coming to a Library Near You! Spotlight Feature

    Science.gov (United States)

    Dopke-Wilson, MariRae

    2009-01-01

    This article features two library media specialists who discovered a way to motivate high school students to read. When most people go to the movies, the "coming attractions" or movie trailers are as anticipated as the popcorn! This Americana movie tradition hooks people again and again on what they will come back to see next. So, it's no surprise…

  12. Spotlight on botulinum toxin and its potential in the treatment of stroke-related spasticity

    Science.gov (United States)

    Kaku, Michelle; Simpson, David M

    2016-01-01

    Poststroke spasticity affects up to one-half of stroke patients and has debilitating effects, contributing to diminished activities of daily living, quality of life, pain, and functional impairments. Botulinum toxin (BoNT) is proven to be safe and effective in the treatment of focal poststroke spasticity. The aim of this review is to highlight BoNT and its potential in the treatment of upper and lower limb poststroke spasticity. We review evidence for the efficacy of BoNT type A and B formulations and address considerations of optimal injection technique, patient and caregiver satisfaction, and potential adverse effects of BoNT. PMID:27022247

  13. Ultraviolet radiation and blue-light emissions from spotlights incorporating tungsten halogen lamps

    CERN Document Server

    MacKinlay, Alistair F; Whillock, M J

    1989-01-01

    This report summarises measurements of the ultraviolet radiation and blue-light emissions from eleven 'desk-top' tungsten halogen (quartz) lamps and one 'floor-standing' tungsten halogen (quartz) lamp available in the UK. Values of occupational hazard weighted and erythemally weighted ultraviolet radiation irradiance and measurements and relevant calculations of blue-light hazards are presented. It is concluded that the safety design of some desk-top tungsten halogen lamps is inadequate to prevent unnecessary exposure of the skin to potentially harmful ultraviolet radiation. It is recommended that all tungsten halogen lamps should have sufficient filtration to reduce their ultraviolet emissions to an acceptably low level. As long as the comfort aversion responses of the eye are respected, direct viewing of the lamps examined should not constitute a retinal hazard.

  14. De Novo Adult Transcriptomes of Two European Brittle Stars: Spotlight on Opsin-Based Photoreception.

    Directory of Open Access Journals (Sweden)

    Jérôme Delroisse

    Full Text Available Next generation sequencing (NGS technology allows to obtain a deeper and more complete view of transcriptomes. For non-model or emerging model marine organisms, NGS technologies offer a great opportunity for rapid access to genetic information. In this study, paired-end Illumina HiSeqTM technology has been employed to analyse transcriptomes from the arm tissues of two European brittle star species, Amphiura filiformis and Ophiopsila aranea. About 48 million Illumina reads were generated and 136,387 total unigenes were predicted from A. filiformis arm tissues. For O. aranea arm tissues, about 47 million reads were generated and 123,324 total unigenes were obtained. Twenty-four percent of the total unigenes from A. filiformis show significant matches with sequences present in reference online databases, whereas, for O. aranea, this percentage amounts to 23%. In both species, around 50% of the predicted annotated unigenes were significantly similar to transcripts from the purple sea urchin, the closest species to date that has undergone complete genome sequencing and annotation. GO, COG and KEGG analyses were performed on predicted brittle star unigenes. We focused our analyses on the phototransduction actors involved in light perception. Firstly, two new echinoderm opsins were identified in O. aranea: one rhabdomeric opsin (homologous to vertebrate melanopsin and one RGR opsin. The RGR-opsin is supposed to be involved in retinal regeneration while the r-opsin is suspected to play a role in visual-like behaviour. Secondly, potential phototransduction actors were identified in both transcriptomes using the fly (rhabdomeric and mammal (ciliary classical phototransduction pathways as references. Finally, the sensitivity of O.aranea to monochromatic light was investigated to complement data available for A. filiformis. The presence of microlens-like structures at the surface of dorsal arm plate of O. aranea could potentially explain phototactic behaviour differences between the two species. The results confirm (i the ability of these brittle stars to perceive light using opsin-based photoreception, (ii suggest the co-occurrence of both rhabdomeric and ciliary photoreceptors, and (iii emphasise the complexity of light perception in this echinoderm class.

  15. Damaging effects of hyperglycemia on cardiovascular function: spotlight on glucose metabolic pathways.

    Science.gov (United States)

    Mapanga, Rudo F; Essop, M Faadiel

    2016-01-15

    The incidence of cardiovascular complications associated with hyperglycemia is a growing global health problem. This review discusses the link between hyperglycemia and cardiovascular diseases onset, focusing on the role of recently emerging downstream mediators, namely, oxidative stress and glucose metabolic pathway perturbations. The role of hyperglycemia-mediated activation of nonoxidative glucose pathways (NOGPs) [i.e., the polyol pathway, hexosamine biosynthetic pathway, advanced glycation end products (AGEs), and protein kinase C] in this process is extensively reviewed. The proposal is made that there is a unique interplay between NOGPs and a downstream convergence of detrimental effects that especially affect cardiac endothelial cells, thereby contributing to contractile dysfunction. In this process the AGE pathway emerges as a crucial mediator of hyperglycemia-mediated detrimental effects. In addition, a vicious metabolic cycle is established whereby hyperglycemia-induced NOGPs further fuel their own activation by generating even more oxidative stress, thereby exacerbating damaging effects on cardiac function. Thus NOGP inhibition, and particularly that of the AGE pathway, emerges as a novel therapeutic intervention for the treatment of cardiovascular complications such as acute myocardial infarction in the presence hyperglycemia. Copyright © 2016 the American Physiological Society.

  16. Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy

    Directory of Open Access Journals (Sweden)

    Zhang Hui

    2007-02-01

    Full Text Available Abstract Recent investigation of Cullin 4 (CUL4 has ushered this class of multiprotein ubiquitin E3 ligases to center stage as critical regulators of diverse processes including cell cycle regulation, developmental patterning, DNA replication, DNA damage and repair, and epigenetic control of gene expression. CUL4 associates with DNA Damage Binding protein 1 (DDB1 to assemble an ubiquitin E3 ligase that targets protein substrates for ubiquitin-dependent proteolysis. CUL4 ligase activity is also regulated by the covalent attachment of the ubiquitin-like protein NEDD8 to CUL4, or neddylation, and the COP9 signalosome complex (CSN that removes this important modification. Recently, multiple WD40-repeat proteins (WDR were found to interact with DDB1 and serve as the substrate-recognition subunits of the CUL4-DDB1 ubiquitin ligase. As more than 150–300 WDR proteins exist in the human genome, these findings impact a wide array of biological processes through CUL4 ligase-mediated proteolysis. Here, we review the recent progress in understanding the mechanism of CUL4 ubiquitin E3 ligase and discuss the architecture of CUL4-assembled E3 ubiquitin ligase complexes by comparison to CUL1-based E3s (SCF. Then, we will review several examples to highlight the critical roles of CUL4 ubiquitin ligase in genome stability, cell cycle regulation, and histone lysine methylation. Together, these studies provide insights into the mechanism of this novel ubiquitin ligase in the regulation of important biological processes.

  17. Spotlight on blisibimod and its potential in the treatment of systemic lupus erythematosus: evidence to date

    Directory of Open Access Journals (Sweden)

    Lenert A

    2017-03-01

    Full Text Available Aleksander Lenert,1 Timothy B Niewold,2 Petar Lenert3 1Division of Rheumatology, University of Kentucky, Kentucky Clinic, Lexington, KY, 2Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 3Division of Immunology, Department of Internal Medicine, The University of Iowa, Iowa City, IA, USA Abstract: B cells in general and BAFF (B cell activating factor of the tumor necrosis factor [TNF] family in particular have been primary targets of recent clinical trials in systemic lupus erythematosus (SLE. In 2011, belimumab, a monoclonal antibody against BAFF, became the first biologic agent approved for the treatment of SLE. Follow-up studies have shown excellent long-term safety and tolerability of belimumab. In this review, we critically analyze blisibimod, a novel BAFF-neutralizing agent. In contrast to belimumab that only blocks soluble BAFF trimer but not soluble 60-mer or membrane BAFF, blisibimod blocks with high affinity all three forms of BAFF. Furthermore, blisibimod has a unique structure built on four high-affinity BAFF-binding peptides fused to the IgG1-Fc carrier. It was tested in phase I and II trials in SLE where it showed safety and tolerability. While it failed to reach the primary endpoint in a recent phase II trial, post hoc analysis demonstrated its efficacy in SLE patients with higher disease activity. Based on these results, blisibimod is currently undergoing phase III trials targeting this responder subpopulation of SLE patients. The advantage of blisibimod, compared to its competitors, lies in its higher avidity for BAFF, but a possible drawback may come from its immunogenic potential and the anticipated loss of efficacy over time. Keywords: BAFF, APRIL, lupus, B cells, blisibimod

  18. Builders Challenge High Performance Builder Spotlight: Yavapai College, Chino Valley, Arizona

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-12-22

    Building America Builders Challenge fact sheet on Yavapai College of Chino Valley, Arizona. These college students built a Building America Builders Challenge house that achieved the remarkably low HERS score of -3 and achieved a tight building envelope.

  19. Lifestyle correlates of overweight in adults: a hierarchical approach (the SPOTLIGHT project).

    Science.gov (United States)

    Roda, Célina; Charreire, Hélène; Feuillet, Thierry; Mackenbach, Joreintje D; Compernolle, Sofie; Glonti, Ketevan; Bárdos, Helga; Rutter, Harry; McKee, Martin; Brug, Johannes; De Bourdeaudhuij, Ilse; Lakerveld, Jeroen; Oppert, Jean-Michel

    2016-11-03

    Obesity-related lifestyle behaviors usually co-exist but few studies have examined their simultaneous relation with body weight. This study aimed to identify the hierarchy of lifestyle-related behaviors associated with being overweight in adults, and to examine subgroups so identified. Data were obtained from a cross-sectional survey conducted across 60 urban neighborhoods in 5 European urban regions between February and September 2014. Data on socio-demographics, physical activity, sedentary behaviors, eating habits, smoking, alcohol consumption, and sleep duration were collected by questionnaire. Participants also reported their weight and height. A recursive partitioning tree approach (CART) was applied to identify both main correlates of overweight and lifestyle subgroups. In 5295 adults, mean (SD) body mass index (BMI) was 25.2 (4.5) kg/m 2 , and 46.0 % were overweight (BMI ≥25 kg/m 2 ). CART analysis showed that among all lifestyle-related behaviors examined, the first identified correlate was sitting time while watching television, followed by smoking status. Different combinations of lifestyle-related behaviors (prolonged daily television viewing, former smoking, short sleep, lower vegetable consumption, and lower physical activity) were associated with a higher likelihood of being overweight, revealing 10 subgroups. Members of four subgroups with overweight prevalence >50 % were mainly males, older adults, with lower education, and living in greener neighborhoods with low residential density. Sedentary behavior while watching television was identified as the most important correlate of being overweight. Delineating the hierarchy of correlates provides a better understanding of lifestyle-related behavior combinations which may assist in targeting preventative strategies aimed at tackling obesity.

  20. RE@21 spotlight: most influential papers from the requirements engineering conference

    NARCIS (Netherlands)

    Glinz, Martin; Wieringa, Roelf J.

    Since 2003, an award has been presented annually at the IEEE International Requirements Engineering Conference for the Most Influential Paper presented at the conference 10 years previously. In 2013, we celebrate 21 years of the Requirements Engineering Conference, and we use this as an opportunity

  1. Improving Critical Thinking through Socratic Seminars. Spotlight on Student Success. No. 110.

    Science.gov (United States)

    Polite, Vernon C.; Adams, Arlin Henry

    This research digest reports on the efforts of Socratic Seminar methodology at Lookout Valley Middle School, a small middle school in Chattanooga (Tennessee). An integral part of the Paideia Schools Movement among public schools in Chattanooga, Socratic Seminars are well-planned opportunities for middle school students to engage in intelligent…

  2. Operando surface spectroscopy-placing catalytic solids at work under the spotlight

    NARCIS (Netherlands)

    Arean, C.O.; Weckhuysen, B.M.; Zecchina, A.

    2012-01-01

    Heterogeneous catalysis is involved in the vast majority of industrial chemical processes performed nowadays, and an increased understanding of catalytic reactions is of the utmost relevance to develop a sustainable and cleaner technology. In order to make new (or improved) catalytic solids, an

  3. Generation Me in the spotlight : Linking reality TV to materialism, entitlement, and narcissism

    NARCIS (Netherlands)

    Opree, S.J.; Kühne, R.

    2016-01-01

    Today’s youth, the Generation Me, is deemed materialistic, entitled, and narcissistic. Individuality has become an important value in child-rearing and is cultivated in the media—especially within the reality TV genre. The aim of this study was to investigate whether adolescents’ and emerging

  4. Spotlight on fish: light pollution affects circadian rhythms of European perch but does not cause stress.

    Science.gov (United States)

    Brüning, Anika; Hölker, Franz; Franke, Steffen; Preuer, Torsten; Kloas, Werner

    2015-04-01

    Flora and fauna evolved under natural day and night cycles. However, natural light is now enhanced by artificial light at night, particularly in urban areas. This alteration of natural light environments during the night is hypothesised to alter biological rhythms in fish, by effecting night-time production of the hormone melatonin. Artificial light at night is also expected to increase the stress level of fish, resulting in higher cortisol production. In laboratory experiments, European perch (Perca fluviatilis) were exposed to four different light intensities during the night, 0 lx (control), 1 lx (potential light level in urban waters), 10 lx (typical street lighting at night) and 100 lx. Melatonin and cortisol concentrations were measured from water samples every 3h during a 24 hour period. This study revealed that the nocturnal increase in melatonin production was inhibited even at the lowest light level of 1 lx. However, cortisol levels did not differ between control and treatment illumination levels. We conclude that artificial light at night at very low intensities may disturb biological rhythms in fish since nocturnal light levels around 1 lx are already found in urban waters. However, enhanced stress induction could not be demonstrated. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. THE CURRENT STATUS OF MAPPING IN THE WORLD – SPOTLIGHT ON OCEANIA

    Directory of Open Access Journals (Sweden)

    J. C. Trinder

    2016-06-01

    Full Text Available A summary is presented of the results of questionnaires sent to mapping agencies in Oceania, covering Australia, New Zealand and the Pacific Island countries, to investigate the status of mapping in those countries. After World War II, the Australian Federal Government funded the initial small scale mapping of the whole country leading to increased percentages of map coverage of Australia. Mapping at larger scales is undertaken by the states and territories in Australia, including cadastral mapping. In New Zealand mapping is maintained by Land Information New Zealand (LINZ at 1:50,000 scale and smaller with regular updating. The results of the questionnaires also demonstrate the extent of map coverage in six Pacific Islands, but there is little information available on the actual percent coverage. Overall there are estimated to be an increases in the percentages of coverage of most map scales in Oceania. However, there appear to be insufficient professionals in most Pacific Island countries to maintain the mapping programs. Given that many Pacific Island countries will be impacted by rising sea level in the future, better mapping of these countries is essential. The availability of modern technology especially satellite images, digital aerial photography and airborne lidar data should enable the Pacific Island countries to provide better map products in future, but this would depend on foreign aid on many occasions.

  6. Course Placement Series: Spotlight on High School Math Course Enrollment. Policy Brief

    Science.gov (United States)

    Tennessee Department of Education, 2015

    2015-01-01

    The Tennessee Department of Education explored course enrollment patterns in an effort to better understand in which courses students are enrolling and whether course enrollment policies and procedures are promoting students' interests. This report focuses on math course enrollment patterns throughout high school by following the 2013-14 twelfth…

  7. Angioedema Spotlight: A Closer Examination of Sacubitril/Valsartan Safety Results.

    Science.gov (United States)

    Owens, Ryan E; Oliphant, Carrie S

    2017-01-01

    Incorporation of neprilysin inhibition into heart failure pharmacotherapy regimens has recently been recommended by U.S. guidelines, based on results from the PARADIGM-HF trial comparing sacubitril/valsartan to enalapril. While most of the discussion has focused on efficacy, a closer examination of the safety results, particularly the incidence of angioedema during the run-in and double-blind periods, is also warranted. Although no major safety concerns were identified, an angioedema risk comparable to enalapril was found, primarily in the black population. Therefore, despite combination with an angiotensin receptor blocker, which historically has a lower incidence of angioedema, the addition of neprilysin inhibition yields an angioedema risk profile comparable to angiotensin converting enzyme (ACE) inhibitors. Clinicians should recognize this safety risk when prescribing sacubitril/valsartan and remain vigilant in counseling patients regarding the signs and symptoms of angioedema. As recommended by the guidelines, avoiding sacubitril/valsartan use concurrently or within 36 hours of the last dose of an ACE inhibitor or in patients with a history of angioedema is also crucial to minimize angioedema risk and prevent patient harm. © Copyright 2017 by the American Board of Family Medicine.

  8. Tow plows could help Michigan save time and money on winter maintenance : research spotlight.

    Science.gov (United States)

    2016-11-01

    As winter maintenance costs rise, MDOT is looking into innovative approaches to increase snow removal efficiency. As part of this effort, the department recently estimated the costs and benefits of incorporating tow plows into its equipment fleet. Re...

  9. Obesity in Children and the 'Myth of Psychological Maladjustment': Self-Esteem in the Spotlight.

    Science.gov (United States)

    Hill, Andrew J

    2017-03-01

    There are contrasting views regarding the psychological well-being of children with obesity. Responding to limitations of existing evidence, Jane Wardle in 2005 argued for a 'myth of psychological maladjustment'. This review looks again at self-esteem. The different characterisations of self-esteem each offer value. Global self-esteem is reduced in nearly all studies of youth with obesity. Dimensional self-esteem reveals physical appearance, athletic and social competence as the most affected areas, confirmed by research that has operationalised low self-competence. Children with obesity are also more likely to be victimised by their peers, generally and for their fatness. Victims who bully others appear to preserve some aspects of self-esteem. A relatively small proportion of youth with obesity has low self-esteem, but those with severe and persistent obesity are especially compromised. Weight loss is only weakly associated with improved self-competence suggesting the value of resilience and asset approaches to improving well-being.

  10. Spotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date

    Directory of Open Access Journals (Sweden)

    Lazzerini PE

    2016-09-01

    Full Text Available Pietro Enea Lazzerini,1 Pier Leopoldo Capecchi,1 Giacomo Maria Guidelli,1 Enrico Selvi,1 Maurizio Acampa,2 Franco Laghi-Pasini1 1Department of Medical Sciences, Surgery and Neurosciences, University of Siena, 2Stroke Unit, University Hospital of Siena, Siena, Italy Abstract: Rheumatoid arthritis (RA is a chronic autoimmune inflammatory disease primarily affecting synovial joints and is characterized by persistent high-grade systemic inflammation. Proinflammatory cytokines, particularly interleukin-6 (IL-6, are of crucial importance in the pathogenesis of the disease, driving both joint inflammation and extra-articular comorbidities. Tocilizumab, a humanized IL-6 receptor-inhibiting monoclonal antibody, has been the first, and, to date, the only, IL-6 inhibitor approved for the treatment of RA. Many studies have demonstrated the potency and effectiveness of tocilizumab in controlling disease activity and radiological progression of RA. These successful results have encouraged the development of novel IL-6 inhibitors, among which a promising agent is sirukumab (SRK, a human anti-IL-6 monoclonal antibody currently under evaluation in Phase II/III studies in patients with RA, systemic lupus erythematosus, giant-cell arteritis, and major depressive disorder. The evidence to date indicates SRK as an effective and well-tolerated new therapeutic tool for patients with active RA, with some preliminary data suggesting a specific beneficial impact on relevant systemic complications associated with the disease, such as depression and cardiovascular disease. Conversely, although pathophysiological considerations make plausible the hypothesis that IL-6 blockade with SRK may also be beneficial in the treatment of many diseases other than RA (either autoimmune or not, available clinical data in patients with systemic lupus erythematosus do not seem to support this view, also giving rise to potentially relevant concerns about drug safety. If large Phase III clinical trials currently in progress in patients with RA confirm the efficacy and tolerability of SRK, then in the long term, this drug could, in the near future, occupy a place in the treatment of the disease, potentially also opening the doors to a more extended use of SRK in a wide range of disorders in which IL-6 plays a key pathogenic role. Keywords: sirukumab, rheumatoid arthritis, interleukin-6, tocilizumab, systemic lupus erythematosus, cardiovascular disease, interleukin-6

  11. GqPCR-mediated Signalling in the Spotlight: From Visualization Towards Dissection and Quantification

    NARCIS (Netherlands)

    Jalink, K.; Adjobo-Hermans, M.J.W.

    2014-01-01

    Signals relayed through G protein-coupled receptors (GPCR) play pivotal roles in human physiology and are important drug targets. About 40% of all GPCRs couple to the heterotrimeric G protein Gq. Biochemical studies as well as crystallography have improved our understanding of GqPCRs and their

  12. Taking flight with sensing equipment will deliver benefits across MDOT : research spotlight.

    Science.gov (United States)

    2015-04-01

    Recent strides in technology have opened the doors for using unmanned : aerial vehicles (UAVs, sometimes called drones) throughout MDOT. An : extensive study on the viability of UAVs instrumented with remote : sensors demonstrated a wide range of cos...

  13. Physical Environmental Correlates of Domain-Specific Sedentary Behaviours across Five European Regions (the SPOTLIGHT Project).

    Science.gov (United States)

    Compernolle, Sofie; De Cocker, Katrien; Roda, Célina; Oppert, Jean-Michel; Mackenbach, Joreintje D; Lakerveld, Jeroen; Glonti, Ketevan; Bardos, Helga; Rutter, Harry; Cardon, Greet; De Bourdeaudhuij, Ilse

    2016-01-01

    The relation between neighbourhood environmental factors and domain-specific sedentary behaviours among adults remains unclear. This study firstly aims to examine the association of perceived and objectively measured neighbourhood safety, aesthetics, destinations and functionality with transport-related, work-related and leisure-time sedentary behaviour. Secondly, the study aims to assess whether these associations are moderated by age, gender or educational level. In 60 randomly sampled neighbourhoods from 5 urban regions in Europe (Ghent and suburbs, Paris and inner suburbs, Budapest and suburbs, the Randstad, and Greater London), a virtual audit with Google Street View was performed to assess environmental characteristics. A total of 5,205 adult inhabitants of these neighbourhoods reported socio-demographic characteristics, sedentary behaviours, and neighbourhood perceptions in an online survey. Generalized linear mixed models were conducted to examine associations between physical environmental neighbourhood factors and sedentary behaviours. Interaction terms were added to test the moderating role of individual-level socio-demographic variables. Lower levels of leisure-time sedentary behaviour (i.e. all leisure activities except television viewing and computer use) were observed among adults who perceived greater numbers of destinations such as supermarkets, recreational facilities, or restaurants in their neighbourhood, and among adults who lived in a neighbourhood with more objectively measured aesthetic features, such as trees, water areas or public parks. Lower levels of work-related sedentary behaviour were observed among adults who perceived less aesthetic features in their neighbourhood, and among adults who lived in a neighbourhood with less objectively measured destinations. Both age, gender and educational level moderated the associations between neighbourhood environmental factors and sedentary behaviours. Preliminary evidence was found for associations between neighbourhood environmental factors and domain-specific sedentary behaviours among adults. However, these associations varied according to objective or subjective environmental measures. More research is needed to confirm and clarify the associations.

  14. Obesity in Children and the ?Myth of Psychological Maladjustment?: Self-Esteem in the Spotlight

    OpenAIRE

    Hill, Andrew J.

    2017-01-01

    Purpose of Review There are contrasting views regarding the psychological well-being of children with obesity. Responding to limitations of existing evidence, Jane Wardle in 2005 argued for a ?myth of psychological maladjustment?. This review looks again at self-esteem. Recent Findings The different characterisations of self-esteem each offer value. Global self-esteem is reduced in nearly all studies of youth with obesity. Dimensional self-esteem reveals physical appearance, athletic and soci...

  15. Spotlight on Schools. AMAL Aleph Arts and Sciences Technological High School, Petach Tikva.

    Science.gov (United States)

    Rosenfeld, Dina

    1998-01-01

    Israel's AMAL Aleph High School combines advanced technology with regular high school academic studies. This article describes how one English-as-a-Second-Language teacher joined a project to develop an online English student magazine for the Center for Educational Technology Internet site, then used to the project to improve students' English…

  16. TURNING THE SPOTLIGHT ON CLASS REPRESENTATIVES -EMPIRICAL INSIGHTS FROM DOWN UNDER

    Directory of Open Access Journals (Sweden)

    Jane Caruana

    2012-10-01

    Full Text Available Ten months before Ontario became the first Canadian common law province to authorise American-style class actions, class actions became available in the Federal Court of Australia. In these two countries and in the United States, the named plaintiffs, commonly referred to as class representatives, are the only claimants formally in charge of the litigation, on the plaintiff side, whilst the outcome of class actions binds not only them and their opponents but also the claimants that they represent, the absent class members. And yet, to date, there have been no comprehensive studies of class representatives in these three countries. The aim of this article is to partly address this significant lacuna in the international legal literature by providing the findings of an empirical study, that the authors have undertaken, of the persons that acted as class representatives in the class actions that were filed in the first 17 years of the operation of the class action procedure in the Federal Court of Australia. It is hoped that this article will prompt Canadian scholars to undertake similar studies with respect to Canadian class representatives. Dix mois avant que l’Ontario devienne la première province de common law canadienne à autoriser les recours collectifs à l’américaine, la Cour fédérale d’Australie autorisait ceux-ci. Dans ces deux pays, ainsi qu’aux États-Unis, les demandeurs nommés, communément appelés représentants, sont les seuls demandeurs formellement mêlés au litige du côté de la partie demanderesse, tandis que l’issue des recours collectifs lie non seulement les représentants et leurs adversaires, mais aussi les demandeurs qu’ils représentent, c’est-à-dire les personnes inscrites au recours collectif qui sont absentes. Pourtant, il n’y a eu à ce jour aucune étude approfondie sur ces représentants de groupes dans ces trois pays. L’objet du présent article est de combler en partie cette importante lacune dans la littérature juridique internationale en fournissant les conclusions d’une étude empirique effectuée par les auteurs et portant sur les représentants dans le cadre des recours collectifs introduits dans les 17 premières années du régime des recours collectifs devant la Cour fédérale d’Australie. Il est à espérer que le présent article incitera les chercheurs canadiens à entreprendre de telles études en ce qui concerne les représentants de groupes canadiens.

  17. Spotlight on eltrombopag in the treatment of children with chronic immune thrombocytopenia

    OpenAIRE

    Lambert, Michele P

    2016-01-01

    Michele P Lambert,1,2 1Division of Hematology, The Children's Hospital of Philadelphia, 2Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Abstract: Pediatric data on the use of thrombopoietin receptor agonists are fairly limited. The recent approval of eltrombopag by the US Food and Drug Administration for children aged ≥1 year, based on data from two randomized, placebo-controlled clinical trials, may lead to the increas...

  18. Nearly Half of College Student Treatment Admissions Were for Primary Alcohol Abuse. Data Spotlight

    Science.gov (United States)

    Substance Abuse and Mental Health Services Administration, 2012

    2012-01-01

    Many students, and the public in general, believe that drinking alcohol is a normal part of the college experience. Unfortunately, students' efforts to "be sociable" or "fit in" can escalate into substance use behavior that puts their health and well-being at risk: One in four full-time college students have experienced past year alcohol abuse or…

  19. Spotlight on rituximab in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis: current perspectives

    Directory of Open Access Journals (Sweden)

    Moog P

    2015-11-01

    Full Text Available Philipp Moog, Klaus Thuermel Abteilung für Nephrologie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany Abstract: A 54-year-old patient presented to his general practitioner because of strong muscle pain in both thighs. Inflammatory parameters (CRP 16.3 mg/dL and white blood cells (15 g/L were elevated. The patient reported a weight loss of 10 kg in 4 weeks. There was no fever or any other specific symptoms. Urine dipstick examination and computed tomography of the chest were unremarkable. Because of increasing symptoms, the patient was referred to our department. Magnetic resonance tomography showed diffuse inflammatory changes of the muscles of both thighs. Neurological examination and electrophysiology revealed axonal sensorimotor neuropathy and ground-glass opacities of both lungs had occurred. Serum creatinine increased to 229 µmol/L within a few days, with proteinuria of 3.3 g/g creatinine. Kidney biopsy showed diffuse pauci-immune proliferative glomerulonephritis. Proteinase 3-specific antineutrophil cytoplasmic antibodies were markedly increased. Birmingham Vasculitis Activity Score was 35. Within 2 days, serum creatinine further increased to 495 µmol/L. Plasma exchange, high-dose glucocorticosteroids, and hemodialysis were started. The patient received cyclophosphamide 1 g twice and rituximab 375 mg/m2 four times according to the RITUXVAS protocol. Despite ongoing therapy, hemodialysis could not be withdrawn and had to be continued over 3 weeks until diuresis normalized. Glucocorticosteroids were tapered to 20 mg after 2 months, and serum creatinine was 133 µmol/L. However, nephritic urinary sediment reappeared. Another dose of 1 g cyclophosphamide was given, and glucocorticosteroids were raised for another 4 weeks. After 6 months, the daily prednisolone dose was able to be tapered to 5 mg. Serum creatinine was 124 µmol/L, proteinuria further decreased to 382 mg/g creatinine, and the Birmingham Vasculitis Activity Score was 0. Maintenance therapy with rituximab 375 mg/m2 every 6 months was started. At the last visit after 8 months, the patient was still in remission, with only minor persistent dysesthesia of the left foot and a persistent serum creatinine of 133 µmol/L. Keywords: ANCA, GPA, granulomatosis with polyangiitis, MPA, microscopic polyangiitis, management

  20. Cognitive factors shape brain networks for auditory skills: spotlight on auditory working memory.

    Science.gov (United States)

    Kraus, Nina; Strait, Dana L; Parbery-Clark, Alexandra

    2012-04-01

    Musicians benefit from real-life advantages, such as a greater ability to hear speech in noise and to remember sounds, although the biological mechanisms driving such advantages remain undetermined. Furthermore, the extent to which these advantages are a consequence of musical training or innate characteristics that predispose a given individual to pursue music training is often debated. Here, we examine biological underpinnings of musicians' auditory advantages and the mediating role of auditory working memory. Results from our laboratory are presented within a framework that emphasizes auditory working memory as a major factor in the neural processing of sound. Within this framework, we provide evidence for music training as a contributing source of these abilities. © 2012 New York Academy of Sciences.

  1. Research Spotlight: Model suggests path to ending the ongoing Haitian cholera epidemic

    Science.gov (United States)

    Schultz, Colin

    2011-05-01

    Since early November 2010 a deadly cholera epidemic has been spreading across the Caribbean nation of Haiti, killing thousands of people and infecting hundreds of thousands. While infection rates are being actively monitored, health organizations have been left without a clear understanding of exactly how the disease has spread across Haiti. Cholera can spread through exposure to contaminated water, and the disease travels over long distances if an infected individual moves around the country. Using representations of these two predominant dispersion mechanisms, along with information on the size of the susceptible population, the number of infected individuals, and the aquatic concentration of the cholera-causing bacteria for more than 500 communities, Bertuzzo et al. designed a model that was able to accurately reproduce the progression of the Haitian cholera epidemic. (Geophysical Research Letters, doi:10.1029/2011GL046823, 2011)

  2. Spotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy

    Directory of Open Access Journals (Sweden)

    D’Erme AM

    2017-05-01

    Full Text Available Angelo Massimiliano D’Erme,1,2 Marco Romanelli,2 Andrea Chiricozzi2 1Dermatology Unit, Livorno Hospital, Livorno, 2Dermatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Abstract: Atopic dermatitis (AD is among the most common inflammatory skin diseases in children and adults in industrialized countries. Up to one-third of adults (probably a smaller proportion in childhood suffer from moderate-to-severe AD, whose recommended treatment is usually based on systemic therapies. The currently available therapeutics are limited, and AD management becomes challenging in most cases. Over the last few years, new advances in the understanding of AD pathogenic mechanisms and inflammatory pathways have led to the identification of specific therapeutic targets and new molecules have been tested. Dupilumab is a fully human monoclonal antibody directed against the IL-4 receptor α subunit that is able to block the signaling of both IL-4 and IL-13 and achieve rapid and significant improvements in adults with moderate-to-severe AD. Dupilumab is ready to inaugurate a long and promising biological target treatment option for Th2 cell-mediated atopic immune response that characterizes AD. Keywords: dupilumab, atopic dermatitis, eczema, IL-4, IL-13, biologics

  3. MDOT innovation leading to faster, longer-lasting pavement repairs : research spotlight.

    Science.gov (United States)

    2015-01-01

    Current methods of patching pavement must evolve to meet increasing mobility demands. : To address this need, MDOT has been testing a new generation of rapid set full-depth : pavement repair materials. Initial results are promising. The new materials...

  4. The dead end of domestic violence: spotlight on children's narratives during forensic investigations following domestic homicide.

    Science.gov (United States)

    Katz, Carmit

    2014-12-01

    The current study provides an in-depth exploration of the narratives of children who witnessed their father killing their mother. This exploration was conducted using a thematic analysis of the children's forensic interviews based on seven investigative interviews that were conducted with children following the domestic homicide. Investigative interviews were selected for study only for substantiated cases and only if the children disclosed the domestic homicide. All of the investigative interviews were conducted within 24h of the domestic homicide. Thematic analysis revealed the following four key categories: the domestic homicide as the dead end of domestic violence, what I did when daddy killed mommy, that one time that daddy killed mommy, and mommy will feel better and will go back home. The discussion examines the multiple layers of this phenomenon as revealed in the children's narratives and its consequences for professionals within the legal and clinical contexts. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Spotlight: maquiladora employment: new data confirm pickup in Juarez factory jobs

    OpenAIRE

    Roberto Coronado; Jesus Canas

    2010-01-01

    For decades, Mexico's maquiladoras have been a major growth engine in the Rio Grande region, and monthly reports on the industry's employment, wages and production were key barometers for the border region's economy. ; We developed a model to estimate Juarez's monthly maquiladora employment. This model will continue to be a timely indicator of El Paso-Juárez area manufacturing activity, given its track record and Mexico's two-month lag in reporting IMMEX (Maquiladora Manufacturing Industry an...

  6. In Glare of Public Spotlight, College Officials Struggle to Deal with Perceived Lawlessness of Their Athletes.

    Science.gov (United States)

    Lederman, Douglas

    1990-01-01

    Many college athletes have been involved in crimes this year, ranging from misdemeanors to felonies. The incidents are more likely than before to be made public. Coaches and administrators disagree about disciplinary policy, but some institutions are responding with educational programs for athletes. (MSE)

  7. Putting attention in the spotlight: The influence of APOE genotype on visual search in mid adulthood.

    Science.gov (United States)

    Lancaster, Claire; Forster, Sophie; Tabet, Naji; Rusted, Jennifer

    2017-09-15

    The Apolipoprotein E e4 allele is associated with greater cognitive decline with age, yet effects of this gene are also observed earlier in the lifespan. This research explores genotype differences (e2, e3, e4) in the allocation of visuospatial attention in mid-adulthood. Sixty-six volunteers, aged 45-55 years, completed two paradigms probing the active selection of information at the focus of attention (a dynamic scaling task) and perceptual capacity differences. Two methods of statistical comparison (parametric statistics, Bayesian inference) found no significant difference between e4 carriers and the homozygous e3 group on either the dynamic scaling or perceptual load task. E2 carriers, however, demonstrated less efficient visual search performance on the dynamic scaling task. The lack of an e4 difference in visuospatial attention, despite previous suggestion in the literature of genotype effects, indicates that select attentional processes are intact in e4 carriers in mid-adulthood. The association of e2 genotype with slower visual search performance complicates the premised protective effects of this allele in cognitive ageing. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Knowledge-aided Two-dimensional Autofocus for Spotlight SAR Polar Format Imagery

    OpenAIRE

    Mao, Xinhua

    2015-01-01

    Conventional two-dimensional (2-D) autofocus algorithms blindly estimate the phase error in the sense that they do not exploit any a priori information on the structure of the 2-D phase error. As such, they often suffer from low computational efficiency and lack of data redundancy to accurately estimate the 2-D phase error. In this paper, a knowledge-aided (KA) 2-D autofocus algorithm which is based on exploiting a priori knowledge about the 2-D phase error structure, is presented. First, as ...

  9. JEM spotlight: Nuclear desalination--environmental impacts and implications for planning and monitoring activities.

    Science.gov (United States)

    Anastasov, Vladimir; Khamis, Ibrahim

    2010-01-01

    Nuclear desalination has been identified as an option since the 1960s, but only recently, as climate change intensifies, has it gained interest again. Although environmental impacts of nuclear desalination have not been paid a lot of attention in the few implemented projects, now more than ever, it is essential to provide an overview of their nature and magnitude. The gathered information and basic analysis allow for a general comparison of a 200,000 m(3)/d nuclear desalination facility using a once-through cooling system as a reference case, with alternative co-location options. Results of the review indicate that the potential for marine impacts requires careful planning and monitoring. They also reveal that adverse coastal, atmospheric and socio-economic impacts are minor in comparison with other co-location alternatives. The issues regarding public health are discussed and experiences presented. Nuclear desalination facilities are expected to show a better environmental performance than other co-located power/desalination options. Environmental planning and monitoring activities are thus much simpler and their scope smaller, with the most important monitoring parameters listed. In conclusion, the application of nuclear desalination is recommended as a less environmentally harmful option.

  10. Spotlight back on LHW with Yucca Mountain on Trump's horizon

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, St George' s Redditch (United Kingdom)

    2017-08-15

    After years of argument and delay could the US be edging closer to resurrecting proposals to build a national repository for high level nuclear waste (HLW) at Yucca Mountain in Nevada? The federal government has looked at the site with a view to establishing a repository since the 1970s. However, after pouring billions of dollars into projects and studies over the decades, the project remained bogged down in legal battles and opposition from politicians and pressure groups. Now, the US Nuclear Regulatory Commission (NRC) said it had directed its staff to use the equivalent of about EUR 95,000 from the national Nuclear Waste Fund on ''information-gathering activities'' that could pave the way for resuming a licensing review of Yucca Mountain as a potential deep geologic repository (DGR).

  11. Spotlight back on LHW with Yucca Mountain on Trump's horizon

    International Nuclear Information System (INIS)

    Shepherd, John

    2017-01-01

    After years of argument and delay could the US be edging closer to resurrecting proposals to build a national repository for high level nuclear waste (HLW) at Yucca Mountain in Nevada? The federal government has looked at the site with a view to establishing a repository since the 1970s. However, after pouring billions of dollars into projects and studies over the decades, the project remained bogged down in legal battles and opposition from politicians and pressure groups. Now, the US Nuclear Regulatory Commission (NRC) said it had directed its staff to use the equivalent of about EUR 95,000 from the national Nuclear Waste Fund on ''information-gathering activities'' that could pave the way for resuming a licensing review of Yucca Mountain as a potential deep geologic repository (DGR).

  12. [Edematous and painful leg. Pathophysiology in the spotlight: presentation of a case].

    Science.gov (United States)

    Estalayo-Gutiérrez, B

    2013-01-01

    We report on a 74-year-old woman visually impaired and under treatment with amlodipine, valsartan and thyroid hormone. The patient complained of her unique, edematous and painful leg after a local trauma. The worsening was slow and gradual, affecting walk and state of mind. Several unsuccessful diagnoses were done before suspecting and confirming a Complex Regional Pain Syndrome. Edema disappeared dramatically after amlodipine empirical discontinuation. Pain improved gradually with rehabilitation exercises but, mainly, after gaining skills and self-esteem due to cataract surgery of her unique functional eye. It was necessary to decrease thyroid hormone dosage after a long lasting balance. The sympathetic nervous system role of the case is discussed. Copyright © 2012 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

  13. Physical Environmental Correlates of Domain-Specific Sedentary Behaviours across Five European Regions (the SPOTLIGHT Project.

    Directory of Open Access Journals (Sweden)

    Sofie Compernolle

    Full Text Available The relation between neighbourhood environmental factors and domain-specific sedentary behaviours among adults remains unclear. This study firstly aims to examine the association of perceived and objectively measured neighbourhood safety, aesthetics, destinations and functionality with transport-related, work-related and leisure-time sedentary behaviour. Secondly, the study aims to assess whether these associations are moderated by age, gender or educational level.In 60 randomly sampled neighbourhoods from 5 urban regions in Europe (Ghent and suburbs, Paris and inner suburbs, Budapest and suburbs, the Randstad, and Greater London, a virtual audit with Google Street View was performed to assess environmental characteristics. A total of 5,205 adult inhabitants of these neighbourhoods reported socio-demographic characteristics, sedentary behaviours, and neighbourhood perceptions in an online survey. Generalized linear mixed models were conducted to examine associations between physical environmental neighbourhood factors and sedentary behaviours. Interaction terms were added to test the moderating role of individual-level socio-demographic variables.Lower levels of leisure-time sedentary behaviour (i.e. all leisure activities except television viewing and computer use were observed among adults who perceived greater numbers of destinations such as supermarkets, recreational facilities, or restaurants in their neighbourhood, and among adults who lived in a neighbourhood with more objectively measured aesthetic features, such as trees, water areas or public parks. Lower levels of work-related sedentary behaviour were observed among adults who perceived less aesthetic features in their neighbourhood, and among adults who lived in a neighbourhood with less objectively measured destinations. Both age, gender and educational level moderated the associations between neighbourhood environmental factors and sedentary behaviours.Preliminary evidence was found for associations between neighbourhood environmental factors and domain-specific sedentary behaviours among adults. However, these associations varied according to objective or subjective environmental measures. More research is needed to confirm and clarify the associations.

  14. Plant Methods: putting the spotlight on technological innovation in the plant sciences

    Directory of Open Access Journals (Sweden)

    Roberts Michael R

    2005-08-01

    Full Text Available Abstract Plant Methods is a new journal for plant biologists, specialising in the rapid publication of peer-reviewed articles with a focus on technological innovation in the plant sciences. The aim of Plant Methods is to stimulate the development and adoption of new and improved techniques and research tools in plant biology. We hope to promote more consistent standards in the plant sciences, and make readily accessible laboratory and computer-based research tools available to the whole community. This will be achieved by publishing Research articles, Methodology papers and Reviews using the BioMed Central Open Access publishing model. The journal is supported by a prestigious editorial board, whose members all recognise the importance of technological innovation as a driver for basic science.

  15. Lifestyle correlates of overweight in adults: a hierarchical approach (the SPOTLIGHT project)

    NARCIS (Netherlands)

    Roda, C.; Charreire, H.; Feuillet, T.; Mackenbach, J.D.; Compernolle, S.; Glonti, K.; Bárdos, H.; Rutter, H.; McKee, M.; Brug, J.; De Bourdeaudhuij, I.; Lakerveld, J.; Oppert, J.-M.

    2016-01-01

    Background Obesity-related lifestyle behaviors usually co-exist but few studies have examined their simultaneous relation with body weight. This study aimed to identify the hierarchy of lifestyle-related behaviors associated with being overweight in adults, and to examine subgroups so identified.

  16. Language at preschool in Europe: Early years professionals in the spotlight

    NARCIS (Netherlands)

    Michel, M.C.; Kuiken, F.

    2014-01-01

    Over the past few decades early years education throughout Europe has experienced many changes due to higher numbers of children attending centres for early childhood education and care (ECEC), a growing linguistic and cultural diversity in society and a shift from care to education with the focus

  17. Moral Development and Behaviour under the Spotlight of the Neurobiological Sciences

    Science.gov (United States)

    Narvaez, Darcia; Vaydich, Jenny L.

    2008-01-01

    With the aid of techniques such as functional magnetic resonance imaging, neuroscience is providing a new perspective on human behaviour. Many areas of psychology have recognised and embraced the new technologies, methodologies and relevant findings. But how do the tools of neuroscience affect the fields of moral development and moral education?…

  18. Sharing the spotlight in Durban: A report from IAS TB2016 at AIDS2016

    Directory of Open Access Journals (Sweden)

    J.A. Whitaker

    2017-05-01

    Full Text Available Tuberculosis (TB is now recognized as the number one cause of death worldwide due to a single infectious pathogen and is the cause of death in one-third of people living with HIV worldwide. An inaugural pre-conference focused on TB (TB2016 was held at the International AIDS Society Conference AIDS2016. This report focuses on key messages from the TB2016 conference that are important for the medical, public health, activist, and scientific communities. Keywords: Tuberculosis, HIV, Epidemiology, Public health, Treatment, Prevention

  19. Grantee Spotlight: Marvella Ford, Ph.D. - Reducing Barriers to Surgical Cancer Care among African Am

    Science.gov (United States)

    Drs. Marvella E. Ford and Nestor F. Esnaola were awarded a five-year NIH/NIMHD R01 grant to evaluate a patient navigation intervention to reduce barriers to surgical cancer care and improving surgical resection rates in African Americans with lung cancer.

  20. Research Spotlight: Why has oil from the Exxon Valdez persisted so long on beaches?

    Science.gov (United States)

    Tretkoff, Ernie

    2011-01-01

    The 1989 Exxon Valdez oil spill released more than 11 million gallons of oil into Prince William Sound, Alaska, polluting 800 kilometers of beaches. In some areas the spilled oil has persisted on beaches more than 20 years later. To examine the factors affecting the persistence of oil from the spill, Xia et al conducted field studies and numerical modeling of the hydrogeological characteristics of a shallow bedrock beach on Knight Island in western Prince William Sound, the area most heavily polluted by the spill. (Water Resources Research, doi:10.1029/2010WR009179, 2010)

  1. Grantee Spotlight: Dr. Meena Jaggi - Investigating Curcumin (Turmeric) as HPV Repressor for Native A

    Science.gov (United States)

    Dr. Meena Jaggi’s research, funded by an NCI/CRCHD U01 grant, involves the use of curcumin (commonly known as turmeric) to inhibit human papillomavirus (HPV) infection among Native American (NA) women.

  2. Netherlands in the spotlight at the ENLIGHT meeting on particle therapy

    CERN Multimedia

    Virginia Greco (CERN) and Manjit Dosanjh (ENLIGHT co-coordinator)

    2016-01-01

    The annual meeting of ENLIGHT, which focuses on particle therapy for cancer treatment, was held in the Netherlands.   Participants of the annual meeting of ENLIGHT, held in the Netherlands from 15-17 September 2016. The annual meeting of ENLIGHT (European Network for Light Hadron Therapy), which gathers experts working worldwide in centres and research institutions for particle therapy for cancer treatment, was hosted this year by the Dutch National Institute for Subatomic Physics (Nikhef) and the University of Utrecht, in the Netherlands, from 15-17 September. Chaired by the co-coordinator of ENLIGHT, Manjit Dosanjh, and the local organisers, Els Koffeman and Jan Visser from Nikhef, the meeting was attended by almost 100 participants from 15 countries. The Netherlands took centre stage at the ENLIGHT meeting: four brand new centres for proton therapy in the Netherlands are currently at various phases of completion as a consequence of the recent approval by the Dutch government of a plan for mak...

  3. Spotlight on elotuzumab in the treatment of multiple myeloma: the evidence to date

    Directory of Open Access Journals (Sweden)

    Weisel K

    2016-10-01

    Full Text Available Katja Weisel Department of Hematology/Oncology, University Hospital Tuebingen, Tuebingen, Germany Abstract: Despite advances in the treatment of multiple myeloma, it remains an incurable disease, with relapses and resistances frequently observed. Recently, immunotherapies, in particular, monoclonal antibodies, have become important treatment options in anticancer therapies. Elotuzumab is a humanized monoclonal antibody to signaling lymphocytic activation molecule F7, which is highly expressed on myeloma cells and, to a lower extent, on selected leukocyte subsets such as natural killer cells. By directly activating natural killer cells and by antibody-dependent cell-mediated cytotoxicity, elotuzumab exhibits a dual mechanism of action leading to myeloma cell death with minimal effects on normal tissue. In several nonclinical models of multiple myeloma, elotuzumab was effective as a single agent and in combination with standard myeloma treatments, supporting the use of elotuzumab in patients. In combination with lenalidomide and dexamethasone, elotuzumab showed a significant increase in tumor response rates and progression-free survival in patients with relapsed and/or refractory multiple myeloma. This review summarizes the nonclinical and clinical development of elotuzumab as a single agent and in combination with established therapies for the treatment of multiple myeloma. Keywords: multiple myeloma, elotuzumab, SLAMF7, CS1, antibody-based immunotherapy

  4. ITS technologies reduce delay, crashes and emissions, with significant returns on investment : research spotlight.

    Science.gov (United States)

    2015-07-01

    Intelligent transportation systems (ITS) technologies have gained popularity in recent years as a method for relieving road congestion and improving safety through better traf c and incident management. Since 2006, MDOT has invested more than $100 mi...

  5. Carbon fiber post-tensioned cables reduce bridge deck cracking, extend service life : research spotlight.

    Science.gov (United States)

    2008-09-01

    Side-by-side box-beam bridges are low-cost and easy to construct, : but it is difficult to inspect the interior beam webs, which can hide : potential defects such as cracking and other deterioration. A new : design reduces these problems and could do...

  6. Spotlight on Athletes With a Disability: Malaysian Newspaper Coverage of the 2012 London Paralympic Games.

    Science.gov (United States)

    Cheong, Jadeera Phaik Geok; Khoo, Selina; Razman, Rizal

    2016-01-01

    This study analyzed newspaper coverage of the 2012 London Paralympic Games by 8 Malaysian newspapers. Articles and photographs from 4 English-language and 4 Malay-language newspapers were examined from August 28 (1 day before the Games) to September 10, 2012 (1 day after the Games closing). Tables, graphs, letters, fact boxes, and lists of events were excluded from analysis. A total of 132 articles and 131 photographs were analyzed. Content analysis of the newspaper articles revealed that most (62.8%) of the articles contained positive reference to the athletes with a disability. There were equal numbers (39.1%) of action and static shots of athletes. More articles and photographs of Malaysian (58%) than non-Malaysian (42%) athletes with a disability were identified. Only 14.9% of the articles and photographs were related to female athletes with a disability.

  7. "This one is stronger" : Spotlights on the lifelong learning professional-in-action

    NARCIS (Netherlands)

    van der Linden, Josje

    2016-01-01

    Om te kunnen omgaan met de veranderende realiteit in leven en werk, wordt wereldwijd een leven lang leren aangemoedigd. Het vierde duurzame ontwikkelingsdoel, vastgesteld in september 2015, weerspiegelt dit: “het verzekeren van kwalitatief goed onderwijs en het bevorderen van de mogelijkheden om een

  8. Spotlight on ceritinib in the treatment of ALK+ NSCLC: design, development and place in therapy

    Directory of Open Access Journals (Sweden)

    Santarpia M

    2017-07-01

    Full Text Available Mariacarmela Santarpia,1 Maria Grazia Daffinà,1 Alessandro D’Aveni,1 Grazia Marabello,1 Alessia Liguori,1 Elisa Giovannetti,2–4 Niki Karachaliou,5 Maria Gonzalez Cao,6 Rafael Rosell,7,8 Giuseppe Altavilla1 1Medical Oncology Unit, Department of Human Pathology “G. Barresi”, University of Messina, Messina, Italy; 2Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands; 3Department of Nanoscience and Nanotechnologies, CNR-Nano, Institute of Nanoscience and Nanotechnology, 4Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, Pisa, Italy; 5Institute of Oncology Rosell (IOR, University Hospital Sagrat Cor, 6Oncology Department, Institute of Oncology Rosell (IOR, Quirón-Dexeus University Institute, Barcelona, 7Cancer Biology and Precision Medicine Program, Germans Trias i Pujol Research Institute, 8Catalan Institute of Oncology, Germans Trias i Pujol University Hospital, Badalona, Spain Abstract: The identification of echinoderm microtubule-associated protein-like 4 (EML4 and anaplastic lymphoma kinase (ALK fusion gene in non-small cell lung cancer (NSCLC has radically changed the treatment of a subset of patients harboring this oncogenic driver. Crizotinib was the first ALK tyrosine kinase inhibitor to receive fast approval and is currently indicated as the first-line therapy for advanced, ALK-positive NSCLC patients. However, despite crizotinib’s efficacy, patients almost invariably progress, with the central nervous system being one of the most common sites of relapse. Different mechanisms of acquired resistance have been identified, including secondary ALK mutations, ALK copy number alterations and activation of bypass tracks. Different highly potent and brain-penetrant next-generation ALK inhibitors have been developed and tested in NSCLC patients with ALK rearrangements. Ceritinib, a structurally distinct and selective ALK inhibitor, showed 20 times higher potency than crizotinib in inhibiting ALK and had activity against the most common crizotinib-resistant mutations, including L1196M and G1269A, in preclinical models. In Phase I and II studies, ceritinib demonstrated pronounced activity in both crizotinib-naïve and crizotinib-refractory patients, with responses observed regardless of the presence of ALK resistance mutations. Ceritinib was the first ALK inhibitor to be approved for the treatment of crizotinib-refractory, ALK-rearranged NSCLC, and recent results from a Phase III study have demonstrated superior efficacy compared to standard chemotherapy in the first- and second-line setting. We provide an extensive overview of ceritinib from the design of the compound through preclinical data until efficacy and toxicity results from Phase I–III clinical studies. We review the molecular alterations associated with resistance to ceritinib and highlight the importance of obtaining tumor biopsy at progression to tailor therapy based upon the underlying resistance mechanism. We finally provide an outlook on novel rational therapeutic combinations. Keywords: acquired resistance, anaplastic lymphoma kinase gene, non-small cell lung cancer, ALK tyrosine kinase inhibitors

  9. Spotlight on the presenter : a study into presentations of conference papers with PowerPoint

    NARCIS (Netherlands)

    Hertz, B.

    2015-01-01

    Abstract

    1. Introduction

    PowerPoint is the most widely used presentation software tool. As of 2012, PowerPoint had more than 200 million presenters worldwide. Presenters all over the world use the program. Some use it for university teaching, others

  10. Factors Associated with High School Learners' Poor Performance: A Spotlight on Mathematics and Physical Science

    Science.gov (United States)

    Makgato, Moses; Mji, Andile

    2006-01-01

    This study, using a non-experimental, exploratory and descriptive method, established learners' and educators' views about factors that contribute to poor performance in mathematics and physical science. Participants were purposefully selected from seven schools with poor pass rates in District 3 of Tshwane North. Focused group interviews with ten…

  11. Italy on the spotlight: Expo Milan 2015 and Italian Journal of Food Science

    Directory of Open Access Journals (Sweden)

    P. Fantozzi

    2015-12-01

    Full Text Available The year 2015 will certainly be remembered as the Year of the Universal Exposition (EXPO hosted in Milan, Italy, focusing on a hot theme in the current scenario: “Feeding the Planet, Energyfor Life”.This event has drawn a wide international attention towards Italy as a country with peculiar and valuable food traditions, thus strengthening its reputation as “gastronomic capital of theworld” rich in protected designation of origin products (PDOs and characterised by a longstanding food culture.

  12. E-dictionary Use under the Spotlight: Students' Use of Pocket ...

    African Journals Online (AJOL)

    This article reports on the utilisation of pocket electronic dictionaries (PEDs) for writing by learners of English at a Thai university. It aims to enrich the study of dictionary use behaviour by investigating, through the use of combined research methods, exactly what happens when students use PEDs for production.

  13. Cognitive factors shape brain networks for auditory skills: spotlight on auditory working memory

    Science.gov (United States)

    Kraus, Nina; Strait, Dana; Parbery-Clark, Alexandra

    2012-01-01

    Musicians benefit from real-life advantages such as a greater ability to hear speech in noise and to remember sounds, although the biological mechanisms driving such advantages remain undetermined. Furthermore, the extent to which these advantages are a consequence of musical training or innate characteristics that predispose a given individual to pursue music training is often debated. Here, we examine biological underpinnings of musicians’ auditory advantages and the mediating role of auditory working memory. Results from our laboratory are presented within a framework that emphasizes auditory working memory as a major factor in the neural processing of sound. Within this framework, we provide evidence for music training as a contributing source of these abilities. PMID:22524346

  14. Beaconless Georouting Under The Spotlight: Practical Link Models and Application Scenarios

    KAUST Repository

    Bader, Ahmed

    2015-06-18

    Beaconless georouting has emerged as a viable packetforwarding technique in distributed wireless networks, particularly for applications requiring portability and scalability. In this paper, we focus on fine-tuning and developing the analytical tools associated with the study of beaconless georouting protocols. For instance, they have been traditionally analyzed and simulated from the perspective of a single hop only. However, end-to-end performance analysis is instrumental when considering practical application scenarios. Furthermore, beaconless georouting protocols have been studied in literature assuming equal communication ranges for the data and control packets. In reality, this is not true since the communication range is actually a function of the packet length (among other factors). Control packets are typically much shorter than data packets. As a consequence, a substantial discrepancy exists in practice between their respective communication ranges, causing many data packet drops. Accordingly, we introduce two simple strategies for bridging the gap between the control and data packet communication ranges. Our primary objective in this paper is to construct a realistic analysis describing the end-to-end performance of beaconless georouting protocols. Two flagship protocols are selected in this paper for further investigation. For a better perspective, the two protocols are actually compared to a hypothetical limit case, one which offers optimal energy and latency performance. Finally, we present four different application scenarios. For each scenario, we highlight the georouting protocol which performs the best and discuss the reasons behind it. © 2007-2012 IEEE.

  15. Spitzer and Variable Young Stars: Shining a Spotlight on Circumstellar Disks

    Science.gov (United States)

    Cody, Ann Marie; CSI 2264 Team

    2014-01-01

    Since its launch in 2003, the Spitzer Space Telescope has helped to uncover hundreds of disk bearing young stars in clusters by detecting their infrared excesses. Study of the spectral energy distributions of these objects has shed light on disk evolution, dispersal, and the relationship to planet formation. With the start of the Warm Spitzer Mission, mid-infrared time series observations have opened up a new window into the dynamic nature of these systems. Not only are young stellar objects (YSOs) highly variable, but so are their disks! I will review recent findings on mid-infrared variability in young stars, highlighting the Young Stellar Object Variability project and the joint Spitzer/CoRoT Coordinated Synoptic Investigation of NGC 2264. These efforts have resulted in a comprehensive census and categorization of YSO flux behavior at 0.5 through 4.5 microns, on timescales from hours to months. We now have evidence for multiple simultaneous variability mechanisms, supporting the picture of a highly dynamic star-disk system.

  16. Spotlight on fluticasone furoate/umeclidinium/vilanterol in COPD: design, development, and potential place in therapy

    Directory of Open Access Journals (Sweden)

    Lal C

    2016-12-01

    Full Text Available Chitra Lal, Charlie Strange Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, SC, USA Abstract: COPD is characterized by persistent airflow obstruction caused by exposure to irritants including cigarette smoke, dust, and fumes. According to the latest GOLD (Global Initiative for Chronic Obstructive Lung Disease guidelines, a combination of inhaled corticosteroids, long-acting β2 agonists, and long-acting muscarinic receptor antagonists can be used for group D COPD patients who are at high risk for exacerbations. Umeclidinium/fluticasone furoate/vilanterol is one such triple-combination therapy currently under development with some completed and several ongoing clinical trials. This review paper summarizes the pharmacologic profiles of these medications and highlights findings from clinical trials, including safety and efficacy data, while speculating on the role of this therapy in current treatment for COPD. Keywords: COPD, umeclidinium, fluticasone furoate, vilanterol, triple therapy

  17. Spotlight on RESA 6: Regional Implementation of the Learning School Initiative. Catalyst Schools Research Study Report

    Science.gov (United States)

    Hammer, Patricia Cahape

    2016-01-01

    West Virginia's Regional Education Service Agency 6 (RESA 6) serves five districts in the northern panhandle of the state--Brooke, Hancock, Marshall, Ohio, and Wetzel--which together are home to 51 schools. RESA 6 joined the pilot implementation of the Learning School approach in the summer of 2015, as part of the second cohort. RESA 6's group…

  18. Spotlight on RESA 2: Regional Implementation of the Learning School Initiative. Catalyst Schools Research Study Report

    Science.gov (United States)

    Hammer, Patricia Cahape

    2016-01-01

    West Virginia's Regional Education Service Agency 2 (RESA 2) serves six districts in the southwestern part of the state--Cabell, Lincoln, Logan, Mason, Mingo, Wayne--which together have 95 schools. RESA 2 was one of two RESAs to pilot implementation of the Learning School approach, beginning in the summer of 2014. RESA 2's first cohort included…

  19. Spotlight on measles 2010: measles outbreak in Ireland 2009-2010.

    LENUS (Irish Health Repository)

    Gee, S

    2010-01-01

    Measles cases are increasing in Ireland, with 320 cases notified since August 2009. Nearly two-thirds of these cases (n=206) were unvaccinated. In the early stages of the outbreak a substantial number of cases were linked to the Traveller community with some cases also reported among the Roma community, other citizens from eastern Europe and children whose parents objected to vaccination. By February 2010, there had been considerable spread to the general population.

  20. Spotlight on taliglucerase alfa in the treatment of pediatric patients with type 1 Gaucher disease

    Directory of Open Access Journals (Sweden)

    Gupta P

    2017-06-01

    Full Text Available Punita Gupta,1 Gregory M Pastores2 1Division of Genetics, Department of Pediatrics, St. Joseph’s Children’s Hospital, Paterson, New Jersey, USA; 2National Center for Inherited Metabolic Disorders, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland Abstract: Gaucher disease (GD is a heritable storage disorder caused by functional defects of the lysosomal acid β-glucosidase and the accumulation of glucosylceramide within macrophages, resulting in multiple organ dysfunction. There are three commercially available enzyme replacement therapy (ERT products for the treatment of GD type 1 (GD1: imiglucerase, velaglucerase alfa, and taliglucerase alfa. Imiglucerase and velaglucerase alfa are produced in different mammalian cell systems; imiglucerase requires postproduction deglycosylation to expose terminal α-mannose residues, which are required for mannose receptor-mediated uptake by target macrophages. These steps are critical to the success of ERT for the treatment of visceral and hematologic manifestations of GD. Taliglucerase alfa is the first US Food and Drug Administration-approved plant-cell-expressed recombinant human protein, using carrot root cell cultures. Furthermore, it does not require postproduction glycosidic modifications. It is indicated for treatment of adults with GD1 in the US, Israel, Australia, Canada, Chile, Brazil, and other countries, and it is additionally approved for the treatment of pediatric patients in the US, Australia, and Canada and for the treatment of hematologic manifestations in pediatric patients with Type 3 GD in Canada and other countries. Our review focuses on the role of taliglucerase alfa in the pediatric population. A literature search through PubMed (from 1995 up till November 2016 of English language articles was performed with the following terms: Gaucher disease, lysosomal storage disease, taliglucerase. Secondary and tertiary references were obtained by reviewing related articles as well as the website www.Clinicaltrials.gov. It has been demonstrated that taliglucerase alfa is efficacious, with a well-established safety profile in pediatric, ERT-naïve patients with symptomatic GD1, as well as for those patients previously treated with imiglucerase. Keywords: Gaucher disease, enzyme replacement therapy, taliglucerase alfa, pediatrics

  1. Assessing the value of E-Businesses in emerging markets: Spotlight on Romania

    NARCIS (Netherlands)

    Mazurencu-Marinescu, M.; Nijkamp, P.

    2008-01-01

    The e-bubble of 2000 was followed by a slowdown from 2001 to 2003, but recently the markets are e-bubbling again, especially the emerging ones in growing economies. An increasing number of transactions with e-businesses appears to occur which prompts the need for valuing the firms involved and for

  2. A spotlight on preschool: the influence of family factors on children's early literacy skills.

    Directory of Open Access Journals (Sweden)

    Steve M Heath

    Full Text Available Phonological awareness, letter knowledge, oral language (including sentence recall and rapid automatised naming are acknowledged within-child predictors of literacy development. Separate research has identified family factors including socio-economic status, parents' level of education and family history. However, both approaches have left unexplained significant amounts of variance in literacy outcomes. This longitudinal study sought to improve prospective classification accuracy for young children at risk of literacy failure by adding two new family measures (parents' phonological awareness and parents' perceived self-efficacy, and then combining the within-child and family factors.Pre-literacy skills were measured in 102 four year olds (46 girls and 56 boys at the beginning of Preschool, and then at the beginning and end of Kindergarten, when rapid automatised naming was also measured. Family factors data were collected at the beginning of Preschool, and children's literacy outcomes were measured at the end of Year 1 (age 6-7 years.Children from high-risk backgrounds showed poorer literacy outcomes than low-risk students, though three family factors (school socio-economic status, parents' phonological awareness, and family history typically accounted for less Year 1 variance than the within-child factors. Combining these family factors with the end of Kindergarten within-child factors provided the most accurate classification (i.e., sensitivity = .85; specificity = .90; overall correct = .88.Our approach would identify at-risk children for intervention before they began to fail. Moreover, it would be cost-effective because although few at-risk children would be missed, allocation of unnecessary educational resources would be minimised.

  3. Human evolution across the disciplines: spotlights on American anthropology and genetics.

    Science.gov (United States)

    Sommer, Marianne

    2012-01-01

    When thinking about human evolution across the disciplines, terms such as "anthropological genetics" or "genetic anthropology" that brazenly defy the existence of the two-cultures divide seem to promise important insights. They refer to the application of genetic techniques to the past of humankind and human groups, a fact emphasized most strongly by the expression "genetic history." Such daring linguistic alliances have been forming since 1962 when the name "molecular anthropology" was introduced in the American context. This was an opportune moment for biochemists and physical chemists to enter anthropology, because in the U.S. a rapprochement between the fields was aimed for. However, a belief in and a discourse of a hierarchy of disciplines structured along the lines of methodology and epistemic object worked as an obstacle to the achievement of transdisciplinarity. Especially the DNA-sequence, initially approached through the proxy of the protein, was regarded as the most informative historical document due to its distance from the environment and its amenability to rigorous scientific techniques. These notions had a particular power at a time when anthropology was confronted with its legacy of race science. For some, the perceived objectivity of the new molecular approaches and the neutrality of molecules would render anthropology more natural-scientific and by inference less culturally contaminated. Others, to the contrary, believed that this legacy demanded a holistic and ethically reflexive anthropology. The different perceptions thus went along with different understandings of such crucial terms as "anthropology" and "history." In the paper, I revisit interfaces between different anthropological fields in the U.S. context and suggest that the beliefs in a hierarchy of approaches as well as in a nature free from culture embodied in the DNA-sequence has worked as one of the primary obstacles to an integration of these fields.

  4. Controlling the spotlight of attention: visual span size and flexibility in schizophrenia.

    Science.gov (United States)

    Elahipanah, Ava; Christensen, Bruce K; Reingold, Eyal M

    2011-10-01

    The current study investigated the size and flexible control of visual span among patients with schizophrenia during visual search performance. Visual span is the region of the visual field from which one extracts information during a single eye fixation, and a larger visual span size is linked to more efficient search performance. Therefore, a reduced visual span may explain patients' impaired performance on search tasks. The gaze-contingent moving window paradigm was used to estimate the visual span size of patients and healthy participants while they performed two different search tasks. In addition, changes in visual span size were measured as a function of two manipulations of task difficulty: target-distractor similarity and stimulus familiarity. Patients with schizophrenia searched more slowly across both tasks and conditions. Patients also demonstrated smaller visual span sizes on the easier search condition in each task. Moreover, healthy controls' visual span size increased as target discriminability or distractor familiarity increased. This modulation of visual span size, however, was reduced or not observed among patients. The implications of the present findings, with regard to previously reported visual search deficits, and other functional and structural abnormalities associated with schizophrenia, are discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

  5. Sustainable prevention of obesity through integrated strategies: The SPOTLIGHT project’s conceptual framework and design

    OpenAIRE

    Lakerveld, Jeroen; Brug, Johannes; Bot, Sandra; Teixeira, Pedro J.; Rutter, Harry; Woodward, Euan; Samdal, Oddrun; Stockley, Lynn; De Bourdeaudhuij, Ilse; van Assema, Patricia; Robertson, Aileen; Lobstein, Tim; Oppert, Jean-Michel; Ádany, Róza; Nijpels, Giel

    2012-01-01

    Abstract Background The prevalence of overweight and obesity in Europe is high. It is a major cause of the overall rates of many of the main chronic (or non communicable) diseases in this region and is characterized by an unequal socio-economic distribution within the population. Obesity is largely determined by modifiable lifestyle behaviours such as low physical activity levels, sedentary behaviour and consumption of energy dense diets. It is increasingly being recognised that effective res...

  6. Sustainable prevention of obesity through integrated strategies: The SPOTLIGHT project's conceptual framework and design

    NARCIS (Netherlands)

    Lakerveld, J.; Brug, J.; Bot, S.D.M.; Teixeira, P.J.; Rutter, H.; Woodward, E.; Samdal, O.; Stockley, L.; de Bourdeaudhuij, I.; Assema, P.; Robertson, A.; Lobstein, T.; Oppert, J.M.; Adany, R.; Nijpels, G.

    2012-01-01

    Background: The prevalence of overweight and obesity in Europe is high. It is a major cause of the overall rates of many of the main chronic (or non communicable) diseases in this region and is characterized by an unequal socio-economic distribution within the population. Obesity is largely

  7. Inclusive education: A transformation and human rights agenda under spotlight in South Africa

    Directory of Open Access Journals (Sweden)

    Mbulaheni Maguvhe

    2015-11-01

    Full Text Available This study investigated the progress made in the implementation of inclusive education as a transformation and human rights tool since its inception in 2001. The study was conducted upon realising that most people underestimate the transformation and human rights value that inclusive education strives to maintain. The total number of participants interviewed was 84. Data was collected using semi-structured interview schedules for the teachers and community members, whereafter it was presented in thematic sections and qualitatively examined for meaning. The results showed that participants comprising teachers and community members do not know or understand the transformational and human rights value of inclusive education. The participants seemed to be equally aware of inclusive education, but they rated its success and value differently. The participants concurred that the philosophy of inclusive education was noble, but they differed regarding the extent to which it had transformed, added value or played an advocacy role in the lives of learners and the community at large over the years.

  8. Inclusive education: A transformation and human rights agenda under spotlight in South Africa.

    Science.gov (United States)

    Maguvhe, Mbulaheni

    2015-01-01

    This study investigated the progress made in the implementation of inclusive education as a transformation and human rights tool since its inception in 2001. The study was conducted upon realising that most people underestimate the transformation and human rights value that inclusive education strives to maintain. The total number of participants interviewed was 84. Data was collected using semi-structured interview schedules for the teachers and community members, whereafter it was presented in thematic sections and qualitatively examined for meaning. The results showed that participants comprising teachers and community members do not know or understand the transformational and human rights value of inclusive education. The participants seemed to be equally aware of inclusive education, but they rated its success and value differently. The participants concurred that the philosophy of inclusive education was noble, but they differed regarding the extent to which it had transformed, added value or played an advocacy role in the lives of learners and the community at large over the years.

  9. Spotlight on Recent JACS Publications: Hybrid ultrathin films can handle the heat

    NARCIS (Netherlands)

    Benes, Nieck Edwin

    2014-01-01

    As temperatures rise, the performance of membranes for separating gas molecules on the basis of size typically breaks down as a result of increased macromolecular dynamics that compromise the material’s sieving abilities. Now researchers led by Nieck E. Benes present a new method for creating

  10. Spotlight on ceritinib in the treatment of ALK+ NSCLC: design, development and place in therapy

    Science.gov (United States)

    Santarpia, Mariacarmela; Daffinà, Maria Grazia; D’Aveni, Alessandro; Marabello, Grazia; Liguori, Alessia; Giovannetti, Elisa; Karachaliou, Niki; Gonzalez Cao, Maria; Rosell, Rafael; Altavilla, Giuseppe

    2017-01-01

    The identification of echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) fusion gene in non-small cell lung cancer (NSCLC) has radically changed the treatment of a subset of patients harboring this oncogenic driver. Crizotinib was the first ALK tyrosine kinase inhibitor to receive fast approval and is currently indicated as the first-line therapy for advanced, ALK-positive NSCLC patients. However, despite crizotinib’s efficacy, patients almost invariably progress, with the central nervous system being one of the most common sites of relapse. Different mechanisms of acquired resistance have been identified, including secondary ALK mutations, ALK copy number alterations and activation of bypass tracks. Different highly potent and brain-penetrant next-generation ALK inhibitors have been developed and tested in NSCLC patients with ALK rearrangements. Ceritinib, a structurally distinct and selective ALK inhibitor, showed 20 times higher potency than crizotinib in inhibiting ALK and had activity against the most common crizotinib-resistant mutations, including L1196M and G1269A, in preclinical models. In Phase I and II studies, ceritinib demonstrated pronounced activity in both crizotinib-naïve and crizotinib-refractory patients, with responses observed regardless of the presence of ALK resistance mutations. Ceritinib was the first ALK inhibitor to be approved for the treatment of crizotinib-refractory, ALK-rearranged NSCLC, and recent results from a Phase III study have demonstrated superior efficacy compared to standard chemotherapy in the first- and second-line setting. We provide an extensive overview of ceritinib from the design of the compound through preclinical data until efficacy and toxicity results from Phase I–III clinical studies. We review the molecular alterations associated with resistance to ceritinib and highlight the importance of obtaining tumor biopsy at progression to tailor therapy based upon the underlying resistance mechanism. We finally provide an outlook on novel rational therapeutic combinations. PMID:28740365

  11. Lead Halide Perovskite Nanocrystals in the Research Spotlight: Stability and Defect Tolerance

    Science.gov (United States)

    2017-01-01

    This Perspective outlines basic structural and optical properties of lead halide perovskite colloidal nanocrystals, highlighting differences and similarities between them and conventional II–VI and III–V semiconductor quantum dots. A detailed insight into two important issues inherent to lead halide perovskite nanocrystals then follows, namely, the advantages of defect tolerance and the necessity to improve their stability in environmental conditions. The defect tolerance of lead halide perovskites offers an impetus to search for similar attributes in other related heavy metal-free compounds. We discuss the origins of the significantly blue-shifted emission from CsPbBr3 nanocrystals and the synthetic strategies toward fabrication of stable perovskite nanocrystal materials with emission in the red and infrared parts of the optical spectrum, which are related to fabrication of mixed cation compounds guided by Goldschmidt tolerance factor considerations. We conclude with the view on perspectives of use of the colloidal perovskite nanocrystals for applications in backlighting of liquid-crystal TV displays. PMID:28920080

  12. The "spotlight" ... highlighting researchers at work: Krista Gebert: "The beauty of economics"

    Science.gov (United States)

    Sharon Ritter

    2008-01-01

    Economics is the science of allocating scarce resources among unlimited wants." That was Krista Gebert's response when I asked her to define economics for me. Having taught several economics classes at the University of Montana after graduate school, Krista had the definition down to its essence. As an economist with RMRS in Missoula, Krista applies economics...

  13. P4-ATPases on the spotlight: lessons from a green world

    DEFF Research Database (Denmark)

    Lopez Marques, Rosa Laura

    flippases, play an essential role in this transport process. We have recently characterized several members of the P4 subfamily of P-type ATPases as prime candidate lipid flippases in the secretory pathway of several eukaryotic cells. Our studies in yeast, plants and mammalian cells uncovered...

  14. SERENA: A suite of four instruments (ELENA, STROFIO, PICAM and MIPA) on board BepiColombo-MPO for particle detection in the Hermean environment

    Czech Academy of Sciences Publication Activity Database

    Orsini, S.; Livi, S.; Torkar, K.; Trávníček, Pavel M.; SERENA, team.

    2010-01-01

    Roč. 58, 1-2 (2010), s. 166-181 ISSN 0032-0633 Institutional research plan: CEZ:AV0Z30420517 Keywords : Mercury’s exosphere * Magnetospheric plasma * Sun–Mercury interaction * Particle detectors Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 2.344, year: 2010 http://www.sciencedirect.com/science/article/pii/S003206330800278X

  15. Utilización de neumáticos usados como agregado en el hormigón: caso provincia de Santa Elena, Ecuador

    Directory of Open Access Journals (Sweden)

    Armando Saltos

    2017-06-01

    Full Text Available El proyecto encontró un diseño de hormigón con partículas provenientes de neumáticos usados, que después de un proceso de selección, trituración controlada, una dosificación acorde con los parámetros de las normas internacionales de diseño de hormigón del Instituto Americano del Concreto (ACI, la Norma Ecuatoriana de Construcción (NEC, la incorporación de hasta 10 % de caucho triturado como sustituto parcial de agregados gruesos en el diseño de hormigón, se obtienen resultados favorables y de buena resistencia lo que hace que  se pueda utilizar cumpliendo todas las normas ecuatorianas de la construcción. También se realizó un ensayo con un 10% de caucho triturado incorporado como sustituto parcial del agregado fino, resultando ser aún más apropiado para fines constructivos y de elaboración de hormigón. En el presente trabajo de investigación se realiza los ensayos como mezclas separadas. Se efectuaron pruebas de vigas con incorporación de agregados gruesos de hasta 15% cumpliendo las normas, pero no se ejecutó una serie completa. Palabras clave: neumático, agregado, hormigón, resistencia. Abstract The project found a concrete design with particles from used tires, which after a selection process, controlled grinding, a dosage in accordance with the parameters of the American Concrete Institute (ICA international standards of concrete design, Standard (NEC, the incorporation of up to 10% of tired rubber as a partial substitute of coarse aggregates in the concrete design, gives favorable results and good resistance which makes it possible to use all the Ecuadorian standards of the building. A test with 10% of crushed rubber incorporated as a partial substitute of the fine aggregate was also performed, making it even more suitable for construction and concrete processing purposes. In the present research work the tests are performed as separate mixtures. Beams were tested with incorporation of coarse aggregates of up to 15% complying with the standards, but a complete series was not performed. Keywords: Tire, aggregate, concrete, resistance.

  16. Elena de Miguel, Azucena Palacios y Ana Serradilla (eds.) Estructuras Léxicas y Estructura del Léxico, Peter Lang, 2006. 367 p

    DEFF Research Database (Denmark)

    Vinther, Thora

    2008-01-01

    Anmeldelse af en samling artikler der inddrager studiet af ord og ordsammensætninger med mange forskellige tilgange, herunder semantiske og kognitive principper, kontrastivt eller diakront udgangspunkt....

  17. Sistema de monitoreo de embarcaciones de pesca artesanal de Anconcito, provincia de Santa Elena, Ecuador, utilizando tecnología AIS - Automatic Identification System

    Directory of Open Access Journals (Sweden)

    Ashley Avilés Bastidas

    2017-06-01

    Full Text Available Ante la evidente crisis que se está presentando en Ecuador debido al incremento en los índices de robos en altamar, principalmente de los motores fuera de borda de las lanchas de pesca artesanal, es necesario implementar un sistema de control eficaz que ofrezca seguridad para la comunidad pesquera; con este fin se propone un sistema de detección de embarcaciones de pesca artesanal con tecnología AIS. En este estudio se explican todos los beneficios que ofrece esta tecnología que actualmente se usa para el monitoreo de buques, así como las aplicaciones para un sistema de monitoreo de embarcaciones pequeñas, las clases de equipos disponibles y sus principales características. Con este objetivo se propone el diseño de una red que permita ubicar las embarcaciones de la comunidad pesquera de Anconcito, que es una de las zonas más afectadas por la delincuencia. Además, se anticipan los resultados esperados con este diseño y varias alternativas técnicas para mejorar la cobertura del sistema. Abstract Given the evident crisis that is occurring in Ecuador due to the increase in the rates of robberies on the high seas, mainly of the outboard motorboats of the artisanal fishing boats, it is necessary to implement an effective control system that provides security for the fishing community. To this end, a system of detection of artisanal fishing vessels with AIS technology is proposed. In this study, all the benefits of this technology are explained which is currently used for monitoring ships, as well as the applications for a monitoring system of small boats, the kinds of equipment available and their main characteristics. With this objective, the design of a network that allows locate the vessels of the fishing community of Anconcito, which is one of the areas most affected by crime, is proposed. In addition, the expected results with this design and several technical alternatives to improve the coverage of the system are anticipated.

  18. Proyecto de producción de sandia para exportación en la península de Santa Elena

    OpenAIRE

    Alban Wong, Gina; Arnao Franco, Carmen; Mejia Coronel, Marco Tulio

    2009-01-01

    Según datos proporcionados por el Tercer Censo Agropecuario, en el Ecuador se sembraron 1.905 ha. de sandía como monocultivo, en 1.788 unidades de producción agropecuarias (UPAs.). La producción fue de 25.818 toneladas. Además, se sembraron las 363 ha de sandía en cultivos asociados que produjeron 273 t. La siembra de sandía en el Ecuador es desde mayo hasta octubre y se han presentado exportaciones entre los meses de septiembre y diciembre. La cosecha de sandía en el mercado interno...

  19. Liderazgo comunitario y fortalecimiento organizacional del comité barrial Otto Arosemena Gómez, cantón Santa Elena.

    OpenAIRE

    Reyes Muñoz, María Luisa

    2017-01-01

    En una comunidad, el liderazgo surge como una necesidad indispensable en la conducción de los requerimientos, considerado como un componente de vital importancia para las comunidades. El propósito de esta investigación es analizar el proceso de interacción entre el líder de la comunidad y el fortalecimiento organizacional. A través de la entrevista de forma descriptiva, se puede concluir que el líder comunitario es importante en el contexto de la comunidad para el desarrollo de las organizaci...

  20. INCIDENCIA DE LA INVESTIGACION BIBLIOGRAFICA EN EL APRENDIZAJE EN ESTUDIANTES DEL NIVEL BÁSICO DE LA CARRERA ADMINISTRACION DE EMPRESAS DE UNIVERSIDAD ESTATAL PENINSULA DE SANTA ELENA

    Directory of Open Access Journals (Sweden)

    William Caiche

    2016-04-01

    Full Text Available El desarrollo de Hábitos de lectura en estudiantes de educacion superior represent un verdadero reto para el docente, sobre todo porque dicha práctica impulsa la capacidad de analizar y de emitir juicios de valor y consolida las bases cognitivas que recibe en el proceso de aprendizaje, se ha identificado que, el estudiante de Administracion de empresas en el desarrollo de actividades academicas cita referencias bibliograficas que, de manera mayoritaria proviene de consultas de bajo nivel academico, por otro lado, es escaso el numero de referencias que incluyen, esta situacion limita el aprendizaje, y se reflejan en los resultadops de evaluacion del proceso. Este trabajo plantea como objetivo determinar el efecto que tiene en el aprendizaje la implementacion de una guia de investigacion bibliografica paa el nivel basico en los estudiantes de Carrera de Administracion de Empresas de la UPSE; para el efecto se recurre a un diseño de investigacion explicativo que a traves de la compracion del antes y el despues permita verificar el logro de tal objetivo.

  1. Utilización de neumáticos usados como agregado en el hormigón: caso provincia de Santa Elena, Ecuador

    OpenAIRE

    Armando Saltos; Juan Garcés; Linda Ordoñez; Miguel Suarez; Humberto Guerrero

    2017-01-01

    El proyecto encontró un diseño de hormigón con partículas provenientes de neumáticos usados, que después de un proceso de selección, trituración controlada, una dosificación acorde con los parámetros de las normas internacionales de diseño de hormigón del Instituto Americano del Concreto (ACI), la Norma Ecuatoriana de Construcción (NEC), la incorporación de hasta 10 % de caucho triturado como sustituto parcial de agregados gruesos en el diseño de hormigón, se obtienen resultados favorables y ...

  2. Chromium in surface water and groundwater in the surrounding area of a tannery: relationships with water quality baseline, Elena, Cordoba. Argentina

    International Nuclear Information System (INIS)

    Matteoda, E.; Blarasin, M.; Damilano, G.; Cabrera, A.; Giuliano Albo, J.

    2009-01-01

    The basin of the El Barreal stream is a dominantly rural area in which groundwater is used for all activities whereas the stream is used as sink of residues and effluents. The existence of a tannery, which discharge the effluents into a wetland (which is drained by the stream), reveals the need to study the presence of Chromium in surface and groundwater and to compare values derived from pollution with those corresponding to the natural water baseline values. Fifty three samples of surface and groundwater were abstracted and chemical analyses were made, including total Chromium in water and plants. The chemical analysis results were studied by means of conventional and statistical techniques. The local and regional geological characteristics allow us to interpret that Chromium in water is derived from source minerals, being possible to stand out that high values probably are related to nearby serpentinite bodies.The values of total chrome in surface and groundwater are included in the natural quality baseline range calculated for this basin (0,25-5ug/L), exempting those samples with higher values linked to sites with farming activities and to the wetland environment where the Chromium effluent is discharged. In the last place, Chromium was retained in soil and plants whereas the aquifer was affected by a contaminant plume of total dissolved solids because of advective-dispersive transport. In the 2009 monitoring survey, a small increase of Chromium in groundwater was detected in relation to that of 2005, being assumed that partial desorption of Chromium is taking place from the solid phase. (Author) 19 refs.

  3. Detección de compuestos presentes en una especie de Amanita micoparasitada, colectada en el corregimiento de Santa Elena (Antioquia, Colombia)

    OpenAIRE

    Aura Helena Corredor Q.; Liliana Londoño

    2005-01-01

    Para este trabajo se seleccionó una especie de Amanita, parasitada probablemente por un Hyphomycete, que presenta un crecimiento anormal y sobre la cual no existen trabajos previos. Inicialmente se hicieron extracciones etanólicas del material fresco en frío y con soxhlet. Se realizó una marcha fotoquímica preliminar del extracto obtenido y se detectaron coumarinas, alcaloides, fenoles y glicósidos cardiotónicos. Posteriormente se estandarizó que la cromatografía de capa fina con el sistem...

  4. A new species of poeciliid fish, Poeciliopsis santaelena, from Peninsula Santa Elena, Area de Conservación Guanacaste, Costa Rica

    Directory of Open Access Journals (Sweden)

    William A Bussing

    2008-06-01

    Full Text Available An undescribed freshwater fish was recently discovered during a biological inventory of Area de Conservación Guanacaste, northwestern Costa Rica. This new species of Poeciliopsis is closely related to a group of widespread species of small spotted fishes designated as the Poeciliopsis gracilis complex in this study. The complex extends on both versants from southern Mexico to Nicaragua, and with this new finding, extends into Costa Rica. The new species is distinguished from its Central American relatives by its lack of lateral and ventral markings, higher pectoral and caudal-fin counts and more posterior placement of the dorsal fin. Poeciliopsis santaelena is endemic to the Río Potrero Grande, a river whose flow is reduced to just a few pools during the long dry season and flows fully only during very rainy weather. It is just another in a growing list of threatened or endangered species found in this unique peninsular environment. Rev. Biol. Trop. 56 (2: 829-838. Epub 2008 June 30.Recientemente se descubrió una especie no descrita de pez dulceacuícola durante un inventario biológico en Area de Conservación Guanacaste (ACG en el noroeste de Costa Rica. Esta especie nueva del género Poeciliopsis tiene un parentesco cercano con un grupo de especies con puntos en los costados ampliamente distribuidas que se designan en este informe como complejo de Poeciliopsis gracilis. El complejo se extiende en ambas vertientes desde el sur de México hasta Nicaragua. La especie nueva se distingue de sus parientes centroamericanos por su falta de manchas negras laterales y ventrales, mayor número de radios pectorales y caudales, y posición más posterior de la aleta dorsal. Poeciliopsis santaelena, especie endémica de un sólo riachuelo intermitente, es una especie más in la lista de especies en peligro que se encuentra en este peculiar ambiente peninsular.

  5. Posibilidades de Generación de Energía en base al Potencial Geotérmico de la Península de Santa Elena.

    Directory of Open Access Journals (Sweden)

    Hernán E. Poveda Z.

    2015-10-01

    En este estudio, proponemos la posibilidad de utilizar esta energía natural para transformarla en electricidad. Aprovechando las condiciones de algunos de los afloramientos de manantiales de agua caliente y volcanes de lodo que existen en la provincia. Para lo cual hemos propuesto al Instituto Austriaco de tecnología, su asesoría y asistencia para proponer un proyecto al ministerio de electrificación y energías renovables.

  6. Modelo de atención integral de salud comunitaria, comuna San Antonio, parroquia Manglaralto - cantón Santa Elena

    OpenAIRE

    Cerón Tatac, Oscar Iván

    2014-01-01

    El estudio del Modelo de Atención Integral de Salud, aplicado en la Unidad Operativa de Salud de la comuna San Antonio, es un proyecto que va ligado a los requerimientos, demandas y expectativas de los comuneros, mediante la articulación y conjunción de las políticas, lineamientos estratégicos y normativas, adaptadas a la realidad local en la Unidad Operativa de Salud de la comuna San Antonio. En el Capítulo I consta la fundamentación teórica y referencial que guió todo el estudio, establecie...

  7. Chromium in surface water and groundwater in the surrounding area of a tannery: relationships with water quality baseline, Elena, Cordoba. Argentina; Cromo en aguas subterraneas y superficiales en el entorno de una curtiembre, relacion con valores de fondo natural. Elena, Cordoba. Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Matteoda, E.; Blarasin, M.; Damilano, G.; Cabrera, A.; Giuliano Albo, J.

    2009-07-01

    The basin of the El Barreal stream is a dominantly rural area in which groundwater is used for all activities whereas the stream is used as sink of residues and effluents. The existence of a tannery, which discharge the effluents into a wetland (which is drained by the stream), reveals the need to study the presence of Chromium in surface and groundwater and to compare values derived from pollution with those corresponding to the natural water baseline values. Fifty three samples of surface and groundwater were abstracted and chemical analyses were made, including total Chromium in water and plants. The chemical analysis results were studied by means of conventional and statistical techniques. The local and regional geological characteristics allow us to interpret that Chromium in water is derived from source minerals, being possible to stand out that high values probably are related to nearby serpentinite bodies.The values of total chrome in surface and groundwater are included in the natural quality baseline range calculated for this basin (0,25-5ug/L), exempting those samples with higher values linked to sites with farming activities and to the wetland environment where the Chromium effluent is discharged. In the last place, Chromium was retained in soil and plants whereas the aquifer was affected by a contaminant plume of total dissolved solids because of advective-dispersive transport. In the 2009 monitoring survey, a small increase of Chromium in groundwater was detected in relation to that of 2005, being assumed that partial desorption of Chromium is taking place from the solid phase. (Author) 19 refs.

  8. Growing and Supporting the Student and Early Career Pipeline in Earth and Space Sciences - A Spotlight on New AGU Initiatives

    Science.gov (United States)

    Hankin, E. R.; Williams, B. M.; Asher, P. M.; Furukawa, H.; Holm Adamec, B.; Lee, M.; Cooper, P.

    2015-12-01

    The American Geophysical Union (AGU) is home to more than 60,000 scientists from 139 countries. Included in this membership are approximately 20,000 (34%) student and early career members. Many well-established programs within AGU provide a dynamic forum for Earth and Space scientists to advance research, collaborate across disciplines, and communicate the importance and impact of science to society regardless of career stage—programs such as AGU publications, scientific meetings and conferences, honors and recognition, and other educational and scientific forums. Additionally, many AGU program initiatives focusing specifically on supporting student and early career scientists and the global talent pool pipeline ones are actively underway. These include both new and long-standing programs. This presentation will describe (1) the overall demographics and needs in Earth and Space sciences, and (2) AGU's coordinated series of programs designed to help attract, retain and support student and early career scientists—with an emphasis on new programmatic activities and initiatives targeting improved diversity. Included in this presentation are a description of the AGU BrightSTaRS Program, the AGU Berkner Program for international students, a newly established AGU Student & Early Career Conference, the AGU Virtual Poster Showcase initiative, the AGU Meeting Mentor program, and GeoLEAD—an umbrella program being jointly built by a coalition of societies to help address Earth and space sciences talent pool needs.

  9. Spotlight on empagliflozin/metformin fixed-dose combination for the treatment of type 2 diabetes: a systematic review

    Directory of Open Access Journals (Sweden)

    Kedia R

    2016-09-01

    Full Text Available Rohit Kedia,1 Supriya Kulkarni,1 Meredith Ross,1 Vijay Shivaswamy1,2 1Division of Diabetes, Endocrinology, and Metabolism, Department of Internal Medicine, University of Nebraska Medical Center, 2VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA Abstract: The dramatic rise in the prevalence of obesity and diabetes is associated with increased morbidity, mortality, and public health care costs worldwide. The need for new, effective, and long-lasting drugs is urgent. Recent research has focused on the role of the inhibitors of sodium–glucose co-transporter 2 (SGLT-2. Clinical trials have shown that SGLT-2 inhibitors have glycemic efficacy and weight-lowering potential. Dual drug therapy is a recommended therapy for patients with new-onset type 2 diabetes who need significant glycemic control. Fixed-dose combination therapy represents a particularly attractive option as it may reduce pill burden and improve adherence. The combination of metformin and empagliflozin was approved by the US Food and Drug Administration in 2014 and represents a safe and effective means to combat glycemic control and weight gain. The purpose of this systematic review is to summarize the background of the SGLT-2 inhibitors, particularly empagliflozin, and focus on the safety and efficacy of the fixed-dose combination of empagliflozin and metformin. Keywords: diabetes mellitus, empagliflozin, metformin, hyperglycemia, systematic review

  10. Parkinson's disease in the spotlight: unraveling nanoscale α-Synuclein oligomers using ultrasensitive single-molecule spectroscopy

    NARCIS (Netherlands)

    Zijlstra, Niels

    2014-01-01

    During the last 15 years, we have witnessed a major shift in the research focus to understand the cause of amyloid diseases. The attention has shifted from the fully matured amyloid fibrils to the nanometer sized aggregation intermediates called oligomers as the potentially cytotoxic species that

  11. 21st Century-based Soft Skills: Spotlight on Non-cognitive Skills in a Cognitive-laden Dentistry Program

    OpenAIRE

    Marjorie C. Quieng; Pearly P. Lim; Maria Rita D. Lucas

    2015-01-01

    Teaching and learning in the 21st century aim to produce students proficient in content knowledge, specific abilities, literacy, numeracy, and technology uses. From these 21st century skills, soft skills were delineated from these learning outcomes; and defined as intra- and interpersonal skills vital for personal development, social participation, and workplace success. This study has two goals: to determine the perceived extent of integration of 21st century-based soft skills in the cogniti...

  12. Deceptively simple… The deception-general ability and the need to put the liar under the spotlight.

    Directory of Open Access Journals (Sweden)

    Gordon R.T. Wright

    2013-08-01

    Full Text Available This Focused Review expands upon our original paper (You can’t kid a kidder": Interaction between production and detection of deception in an interactive deception task. Frontiers in Human Neuroscience, 6:87. In that paper we introduced a new socially interactive, laboratory-based task, the Deceptive Interaction Task (DeceIT, and used it to measure individuals’ ability to lie, their ability to detect the lies of others, and potential individual difference measures contributing to these abilities. We showed that the two skills were correlated; better liars made better lie detectors (a deception general ability and this ability seemed to be independent of cognitive (IQ and emotional (EQ intelligence. Here, following the Focused Review format, we outline the method and results of the original paper and comment more on the value of lab-based experimental studies of deception, which have attracted criticism in recent years. While acknowledging that experimental paradigms may fail to recreate the full complexity and potential seriousness of real-world deceptive behavior, we suggest that lab-based deception paradigms can offer valuable insight into ecologically-valid deceptive behavior. The use of the DeceIT procedure enabled deception to be studied in an interactive setting, with motivated participants, and importantly allowed the study of both the liar and the lie detector within the same deceptive interaction. It is our thesis that by addressing deception more holistically - by bringing the liar into the ‘spotlight’ which is typically trained exclusively on the lie detector – we may further enhance our understanding of deception.

  13. Fibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction.

    Science.gov (United States)

    Tenenbaum, Alexander; Fisman, Enrique Z

    2012-10-11

    Currently the world faces epidemic of several closely related conditions: obesity, metabolic syndrome and type 2 diabetes (T2DM). The lipid profile of these patients and those with metabolic syndrome is characterized by the concurrent presence of qualitative as well as quantitative lipoprotein abnormalities: low levels of HDL, increased triglycerides, and prevalence of LDL particles that are smaller and denser than normal. This lipid phenotype has been defined as atherogenic dyslipidemia. Overwhelming evidences demonstrate that all components of the atherogenic dyslipidemia are important risk-factors for cardiovascular diseases. Optimal reduction of cardiovascular risk through comprehensive management of atherogenic dyslipidemias basically depends of the presence of efficacious lipid-modulating agents (beyond statin-based reduction of LDL-C). The most important class of medications which can be effectively used nowadays to combat atherogenic dyslipidemias is the fibrates. From a clinical point of view, in all available 5 randomized control trials beneficial effects of major fibrates (gemfibrozil, fenofibrate, bezafibrate) were clearly demonstrated and were highly significant in patients with atherogenic dyslipidemia. In these circumstances, the main determinant of the overall results of the trial is mainly dependent of the number of the included appropriate patients with atherogenic dyslipidemia. In a meta-analysis of dyslipidemic subgroups totaling 4726 patients a significant 35% relative risk reduction in cardiovascular events was observed compared with a non significant 6% reduction in those without dyslipidemia. However, different fibrates may have a somewhat different spectrum of effects. Currently only fenofibrate was investigated and proved to be effective in reducing microvascular complications of diabetes. Bezafibrate reduced the severity of intermittent claudication. Cardinal differences between bezafibrate and other fibrates are related to the effects on glucose metabolism and insulin resistance. Bezafibrate is the only clinically available pan - (alpha, beta, gamma) PPAR balanced activator. Bezafibrate decreases blood glucose level, HbA1C, insulin resistance and reduces the incidence of T2DM compared to placebo or other fibrates. Among major fibrates, bezafibrate appears to have the strongest and fenofibrate the weakest effect on HDL-C. Current therapeutic use of statins as monotherapy is still leaving many patients with atherogenic dyslipidemia at high risk for coronary events because even intensive statin therapy does not eliminate the residual cardiovascular risk associated with low HDL and/or high triglycerides. As compared with statin monotherapy (effective mainly on LDL-C levels and plaque stabilization), the association of a statin with a fibrate will also have a major impact on triglycerides, HDL and LDL particle size. Moreover, in the specific case of bezafibrate one could expect neutralizing of the adverse pro-diabetic effect of statins. Though muscle pain and myositis is an issue in statin/fibrate treatment, adverse interaction appears to occur to a significantly greater extent when gemfibrozil is administered. However, bezafibrate and fenofibrate seems to be safer and better tolerated. Combined fibrate/statin therapy is more effective in achieving a comprehensive lipid control and may lead to additional cardiovascular risk reduction, as could be suggested for fenofibrate following ACCORD Lipid study subgroup analysis and for bezafibrate on the basis of one small randomized study and multiple observational data. Therefore, in appropriate patients with atherogenic dyslipidemia fibrates- either as monotherapy or combined with statins - are consistently associated with reduced risk of cardiovascular events. Fibrates currently constitute an indispensable part of the modern anti-dyslipidemic arsenal for patients with atherogenic dyslipidemia.

  14. Spotlight on opicapone as an adjunct to levodopa in Parkinson’s disease: design, development and potential place in therapy

    Directory of Open Access Journals (Sweden)

    Annus Á

    2017-01-01

    Full Text Available Ádám Annus,1 László Vécsei1,2 1Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, 2MTA-SZTE Neuroscience Research Group, Szeged, Hungary Abstract: Parkinson’s disease (PD is a progressive, chronic, neurodegenerative disease characterized by rigidity, tremor, bradykinesia and postural instability secondary to dopaminergic deficit in the nigrostriatal system. Currently, disease-modifying therapies are not available, and levodopa (LD treatment remains the gold standard for controlling motor and nonmotor symptoms of the disease. LD is extensively and rapidly metabolized by peripheral enzymes, namely, aromatic amino acid decarboxylase and catechol-O-methyltransferase (COMT. To increase the bioavailability of LD, COMT inhibitors are frequently used in clinical settings. Opicapone is a novel COMT inhibitor that has been recently approved by the European Medicines Agency as an adjunctive therapy to combinations of LD and aromatic amino acid decarboxylase inhibitor in adult PD patients with end-of-dose motor fluctuations. We aimed to review the biochemical properties of opicapone, summarize its preclinical and clinical trials and discuss its future potential role in the treatment of PD. Keywords: Parkinson’s disease, COMT inhibitors, opicapone

  15. GSD Update: Year in Review: Spotlight on 2017 Research by the Grassland, Shrubland and Desert Ecosystems Science Program

    Science.gov (United States)

    Deborah M. Finch

    2018-01-01

    In this issue of the GSD Update, we feature selected studies of the RMRS Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that focus on the theme of fire. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic priorities and goals of the USDA Forest...

  16. Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy

    Directory of Open Access Journals (Sweden)

    Donald BJ

    2017-12-01

    Full Text Available Bryan J Donald,1,2 Salim Surani,3–5 Harmeet S Deol,1,6 Uche J Mbadugha,1 George Udeani1,7 1Department of Pharmacy, Corpus Christi Medical Center, Corpus Christi, TX, 2Department of Clinical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA, 3Department of Pulmonology/Critical Care, Corpus Christi Medical Center, Corpus Christi, TX, 4Department of Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX, 5Department of Medicine, College of Osteopathic Medicine, University of North Texas Health Science Center, Denton, TX, 6Department of Pharmacy Services, Yale New Haven Hospital, New Haven, CT, 7Pharmacy Practice, College of Pharmacy, Texas A&M University Health Science Center, Kingsville, TX, USA Abstract: Community-acquired bacterial pneumonia (CABP is a leading cause of death worldwide. However, antibacterial agents used to treat common pathogens in CABP are marked by adverse drug events and increasing antimicrobial resistance. Solithromycin is a new ketolide antibiotic, based on the macrolide antibiotic structure, being studied for use in CABP. It has efficacy in vitro against the common causative pathogens in CABP including Streptococcus pneumoniae, Haemophilus influenzae, and atypical pathogens. In Phase II and Phase III clinical trials, it has been demonstrated efficacious as a single agent for treatment of CABP with an apparently milder adverse event profile than alternative agents. Keywords: solithromycin, macrolide antibiotics, community-acquired bacterial pneumonia, CABP

  17. Spotlight on the use of new natural surfactants in colloidal gas aphron (CGA) fluids: A mechanistic study

    Science.gov (United States)

    Ali Ahmadi, Mohammad; Galedarzadeh, Morteza; Reza Shadizadeh, Seyed

    2017-12-01

    Colloidal gas aphron-based (CGA) drilling fluids are defined as gas bubbles with diameters in ranges of 10 to 100 microns which are created by intensive stirring of an aphronizer surfactant solution at high speed. Furthermore, CGA-based drilling fluid properties like stability and aphron size distribution extremely depend on the inherent characteristics of the aphronizer surfactant. The selection of an appropriate surface active agent plays a vital role in the generation of micro-bubbles with the favorable characteristics. The primary motivation behind this paper is to evaluate the potential of new natural surfactants as aphronizer in CGA-based drilling fluids. Here, two new natural based surfactants derived from roots of Glycyrrhiza glabra and leaves of Matricaria recutita plant are implemented for the preparation of aphron-based fluids. The physico-chemical properties of the aphronized fluids prepared from these surfactants are studied by different fundamental tests comprising rheological characterizations, bubble size measurements, and stability tests. The effect of polymer and surfactant concentration was also evaluated. According to the experimental outcomes of this research, the two introduced natural surfactants are appropriate for generating CGA-based drilling fluids while they have no environmental impacts and have very low cost in comparison to commercial and industrial surfactants.

  18. Spotlight on brimonidine topical gel 0.33% for facial erythema of rosacea: safety, efficacy, and patient acceptability

    Directory of Open Access Journals (Sweden)

    Anderson MS

    2017-07-01

    Full Text Available Michael S Anderson,1 Anish Nadkarni,1 Leah A Cardwell,1 Hossein Alinia,1 Steven R Feldman1–3 1Department of Dermatology, Center for Dermatology Research, 2Department of Pathology, 3Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Background: Brimonidine tartrate is a highly selective alpha 2 agonist that induces direct vasoconstriction of small arteries and veins, thereby reducing vasodilation and edema. Objective: To review the current literature regarding the safety, efficacy, and patient acceptability of brimonidine 0.33% gel.Methods: A PubMed search was performed using the terms brimonidine 0.33% gel, rosacea, safety, efficacy, and acceptability. Peer-reviewed clinical trials and case reports from 2012 to 2016 were screened for inclusion of safety, efficacy, and/or patient acceptability data.Results: Brimonidine topical gel 0.33% is associated with mild, transient skin-related adverse reactions. Efficacy may be achieved within 30 minutes of administration with maximal reductions in erythema 3–6 hours after administration. Patient satisfaction with use of brimonidine topical gel is superior to vehicle gel for facial appearance, treatment effect, facial redness, and daily control of facial redness.Limitations: Studies were typically limited to 1-year follow-up. Only one study has examined the use of brimonidine topical gel in combination with other rosacea and acne medications.Discussion: Brimonidine topical gel 0.33% is a safe, effective, and patient-accepted treatment for facial erythema of rosacea. Keywords: patient satisfaction, adverse reactions, side effects 

  19. Strategic Frameworks for Human Performance and Human Systems Integration: Spotlight on General Systems Performance Theory and Nonlinear Causal Resource Analysis

    Science.gov (United States)

    2010-12-14

    have the mandate that DoD has in the form of DODI 5000.02, to conduct HSI. However, it is developing an HSI culture. The Constellation program...cancelation of Constellation and the fast-approaching end of the Space Shuttle era, combined with budget concerns, creates a window of opportunity to...review the importance of considering human integration when systems are first envisioned and requirements set. For example, if continued the Orion

  20. Deficiencies in Natura 2000 for protecting recovering large carnivores: A spotlight on the wolf Canis lupus in Poland.

    Directory of Open Access Journals (Sweden)

    Tom A Diserens

    Full Text Available If protected areas are to remain relevant in our dynamic world they must be adapted to changes in species ranges. In the EU one of the most notable such changes is the recent recovery of large carnivores, which are protected by Natura 2000 at the national and population levels. However, the Natura 2000 network was designed prior to their recent recovery, which raises the question whether the network is sufficient to protect the contemporary ranges of large carnivores. To investigate this question we evaluated Natura 2000 coverage of the three wolf Canis lupus populations in Poland. Wolf tracking data showed that wolves have recolonised almost all suitable habitat in Poland (as determined by a recent habitat suitability model, so we calculated the overlap between the Natura 2000 network and all wolf habitat in Poland. On the basis of published Natura 2000 criteria, we used 20% as the minimum required coverage. At the national level, wolves are sufficiently protected (22% coverage, but at the population level, the Baltic and Carpathian populations are far better protected (28 and 47%, respectively than the endangered Central European Lowland population (12%. As Natura 2000 insufficiently protects the most endangered wolf population in Poland, we recommend expansion of Natura 2000 to protect at least an additional 8% of wolf habitat in western Poland, and discuss which specific forests are most in need of additional coverage. Implementation of these actions will have positive conservation implications and help Poland to fulfil its Habitats Directive obligations. As it is likely that similar gaps in Natura 2000 are arising in other EU member states experiencing large carnivore recoveries, particularly in Central Europe, we make the case for a flexible approach to Natura 2000 and suggest that such coverage evaluations may be beneficial elsewhere.

  1. GSD Update: Year in Review: Spotlight on 2013 research by the Grassland, Shrubland and Desert Ecosystems Science Program

    Science.gov (United States)

    Deborah M. Finch

    2014-01-01

    In this issue of the GSD Update, we take a look back at selected studies of the Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that depict its strengths and focus areas. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic research priorities of the...

  2. GSD Update: Year in Review: Spotlight on 2015 Research by the Grassland, Shrubland and Desert Ecosystems Science Program

    Science.gov (United States)

    Deborah. Finch

    2016-01-01

    In this issue of the GSD Update, we take a look back at selected studies of the Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that depict its strengths and focus areas. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic research...

  3. Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets

    Directory of Open Access Journals (Sweden)

    Armelle T. Mbaveng

    2017-06-01

    Full Text Available Cancer remains a major health hurdle worldwide and has moved from the third leading cause of death in the year 1990 to second place after cardiovascular disease since 2013. Chemotherapy is one of the most widely used treatment modes; however, its efficiency is limited due to the resistance of cancer cells to cytotoxic agents. The present overview deals with the potential of the flora of Central, Eastern and Western African (CEWA regions as resource for anticancer drug discovery. It also reviews the molecular targets of phytochemicals of these plants such as ABC transporters, namely P-glycoprotein (P-gp, multi drug-resistance-related proteins (MRPs, breast cancer resistance protein (BCRP, ABCG2 as well as the epidermal growth factor receptor (EGFR/ErbB-1/HER1, human tumor suppressor protein p53, caspases, mitochondria, angiogenesis, and components of MAP kinase signaling pathways. Plants with the ability to preferentially kills resistant cancer cells were also reported. Data compiled in the present document were retrieved from scientific websites such as PubMed, Scopus, Sciencedirect, Web-of-Science, and Scholar Google. In summary, plant extracts from CEWA and isolated compounds thereof exert cytotoxic effects by several modes of action including caspases activation, alteration of mitochondrial membrane potential (MMP, induction of reactive oxygen species (ROS in cancer cells and inhibition of angiogenesis. Ten strongest cytotoxic plants from CEWA recorded following in vitro screening assays are: Beilschmiedia acuta Kosterm, Echinops giganteus var. lelyi (C. D. Adams A. Rich., Erythrina sigmoidea Hua (Fabaceae, Imperata cylindrical Beauv. var. koenigii Durand et Schinz, Nauclea pobeguinii (Pobég. ex Pellegr. Merr. ex E.M.A., Piper capense L.f., Polyscias fulva (Hiern Harms., Uapaca togoensis Pax., Vepris soyauxii Engl. and Xylopia aethiopica (Dunal A. Rich. Prominent antiproliferative compounds include: isoquinoline alkaloid isotetrandrine (51, two benzophenones: guttiferone E (26 and isoxanthochymol (30, the isoflavonoid 6α-hydroxyphaseollidin (9, the naphthyl butenone guieranone A (25, two naphthoquinones: 2-acetylfuro-1,4-naphthoquinone (4 and plumbagin (37 and xanthone V1 (46. However, only few research activities in the African continent focus on cytotoxic drug discovery from botanicals. The present review is expected to stimulate further scientific efforts to better valorize the African flora.

  4. Fibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction

    Directory of Open Access Journals (Sweden)

    Tenenbaum Alexander

    2012-10-01

    Full Text Available Abstract Currently the world faces epidemic of several closely related conditions: obesity, metabolic syndrome and type 2 diabetes (T2DM. The lipid profile of these patients and those with metabolic syndrome is characterized by the concurrent presence of qualitative as well as quantitative lipoprotein abnormalities: low levels of HDL, increased triglycerides, and prevalence of LDL particles that are smaller and denser than normal. This lipid phenotype has been defined as atherogenic dyslipidemia. Overwhelming evidences demonstrate that all components of the atherogenic dyslipidemia are important risk-factors for cardiovascular diseases. Optimal reduction of cardiovascular risk through comprehensive management of atherogenic dyslipidemias basically depends of the presence of efficacious lipid-modulating agents (beyond statin-based reduction of LDL-C. The most important class of medications which can be effectively used nowadays to combat atherogenic dyslipidemias is the fibrates. From a clinical point of view, in all available 5 randomized control trials beneficial effects of major fibrates (gemfibrozil, fenofibrate, bezafibrate were clearly demonstrated and were highly significant in patients with atherogenic dyslipidemia. In these circumstances, the main determinant of the overall results of the trial is mainly dependent of the number of the included appropriate patients with atherogenic dyslipidemia. In a meta-analysis of dyslipidemic subgroups totaling 4726 patients a significant 35% relative risk reduction in cardiovascular events was observed compared with a non significant 6% reduction in those without dyslipidemia. However, different fibrates may have a somewhat different spectrum of effects. Currently only fenofibrate was investigated and proved to be effective in reducing microvascular complications of diabetes. Bezafibrate reduced the severity of intermittent claudication. Cardinal differences between bezafibrate and other fibrates are related to the effects on glucose metabolism and insulin resistance. Bezafibrate is the only clinically available pan - (alpha, beta, gamma PPAR balanced activator. Bezafibrate decreases blood glucose level, HbA1C, insulin resistance and reduces the incidence of T2DM compared to placebo or other fibrates. Among major fibrates, bezafibrate appears to have the strongest and fenofibrate the weakest effect on HDL-C. Current therapeutic use of statins as monotherapy is still leaving many patients with atherogenic dyslipidemia at high risk for coronary events because even intensive statin therapy does not eliminate the residual cardiovascular risk associated with low HDL and/or high triglycerides. As compared with statin monotherapy (effective mainly on LDL-C levels and plaque stabilization, the association of a statin with a fibrate will also have a major impact on triglycerides, HDL and LDL particle size. Moreover, in the specific case of bezafibrate one could expect neutralizing of the adverse pro-diabetic effect of statins. Though muscle pain and myositis is an issue in statin/fibrate treatment, adverse interaction appears to occur to a significantly greater extent when gemfibrozil is administered. However, bezafibrate and fenofibrate seems to be safer and better tolerated. Combined fibrate/statin therapy is more effective in achieving a comprehensive lipid control and may lead to additional cardiovascular risk reduction, as could be suggested for fenofibrate following ACCORD Lipid study subgroup analysis and for bezafibrate on the basis of one small randomized study and multiple observational data. Therefore, in appropriate patients with atherogenic dyslipidemia fibrates- either as monotherapy or combined with statins – are consistently associated with reduced risk of cardiovascular events. Fibrates currently constitute an indispensable part of the modern anti-dyslipidemic arsenal for patients with atherogenic dyslipidemia.

  5. Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy.

    Science.gov (United States)

    Donald, Bryan J; Surani, Salim; Deol, Harmeet S; Mbadugha, Uche J; Udeani, George

    2017-01-01

    Community-acquired bacterial pneumonia (CABP) is a leading cause of death worldwide. However, antibacterial agents used to treat common pathogens in CABP are marked by adverse drug events and increasing antimicrobial resistance. Solithromycin is a new ketolide antibiotic, based on the macrolide antibiotic structure, being studied for use in CABP. It has efficacy in vitro against the common causative pathogens in CABP including Streptococcus pneumoniae , Haemophilus influenzae , and atypical pathogens. In Phase II and Phase III clinical trials, it has been demonstrated efficacious as a single agent for treatment of CABP with an apparently milder adverse event profile than alternative agents.

  6. Put the concert attendee in the spotlight : A user-centered design and development approach for classical concert applications

    NARCIS (Netherlands)

    Melenhorst, M.S.; Liem, C.C.S.

    2015-01-01

    As the importance of real-life use cases in the music information retrieval (MIR) field is increasing, so does the importance of understanding user needs. The development of innovative real-life applications that draw on MIR technology requires a user-centered design and development approach that

  7. Spotlight on Digital Government Information Preservation: Examining the Context, Outcomes, Limitations, and Successes of the DataRefuge Movement

    OpenAIRE

    Eric Johnson; Alicia Kubas

    2018-01-01

    In Brief: Access and preservation of online government data and information has been a long-standing and complex issue for librarians in government information librarianship, but it has recently started to receive attention on a larger level from the media, public, and libraries in general. The most recent initiative to archive digital government data was the DataRefuge movement in 2016 and 2017.

  8. Autofocus Correction of Azimuth Phase Error and Residual Range Cell Migration in Spotlight SAR Polar Format Imagery

    OpenAIRE

    Mao, Xinhua; Zhu, Daiyin; Zhu, Zhaoda

    2012-01-01

    Synthetic aperture radar (SAR) images are often blurred by phase perturbations induced by uncompensated sensor motion and /or unknown propagation effects caused by turbulent media. To get refocused images, autofocus proves to be useful post-processing technique applied to estimate and compensate the unknown phase errors. However, a severe drawback of the conventional autofocus algorithms is that they are only capable of removing one-dimensional azimuth phase errors (APE). As the resolution be...

  9. Spotlight on the Underdogs-An Analysis of Underrepresented Alternaria Mycotoxins Formed Depending on Varying Substrate, Time and Temperature Conditions.

    Science.gov (United States)

    Zwickel, Theresa; Kahl, Sandra M; Klaffke, Horst; Rychlik, Michael; Müller, Marina E H

    2016-11-19

    Alternaria (A.) is a genus of widespread fungi capable of producing numerous, possibly health-endangering Alternaria toxins (ATs), which are usually not the focus of attention. The formation of ATs depends on the species and complex interactions of various environmental factors and is not fully understood. In this study the influence of temperature (7 °C, 25 °C), substrate (rice, wheat kernels) and incubation time (4, 7, and 14 days) on the production of thirteen ATs and three sulfoconjugated ATs by three different Alternaria isolates from the species groups A. tenuissima and A. infectoria was determined. High-performance liquid chromatography coupled with tandem mass spectrometry was used for quantification. Under nearly all conditions, tenuazonic acid was the most extensively produced toxin. At 25 °C and with increasing incubation time all toxins were formed in high amounts by the two A. tenuissima strains on both substrates with comparable mycotoxin profiles. However, for some of the toxins, stagnation or a decrease in production was observed from day 7 to 14. As opposed to the A. tenuissima strains, the A. infectoria strain only produced low amounts of ATs, but high concentrations of stemphyltoxin III. The results provide an essential insight into the quantitative in vitro AT formation under different environmental conditions, potentially transferable to different field and storage conditions.

  10. Spotlight on the Underdogs—An Analysis of Underrepresented Alternaria Mycotoxins Formed Depending on Varying Substrate, Time and Temperature Conditions

    Science.gov (United States)

    Zwickel, Theresa; Kahl, Sandra M.; Klaffke, Horst; Rychlik, Michael; Müller, Marina E. H.

    2016-01-01

    Alternaria (A.) is a genus of widespread fungi capable of producing numerous, possibly health-endangering Alternaria toxins (ATs), which are usually not the focus of attention. The formation of ATs depends on the species and complex interactions of various environmental factors and is not fully understood. In this study the influence of temperature (7 °C, 25 °C), substrate (rice, wheat kernels) and incubation time (4, 7, and 14 days) on the production of thirteen ATs and three sulfoconjugated ATs by three different Alternaria isolates from the species groups A. tenuissima and A. infectoria was determined. High-performance liquid chromatography coupled with tandem mass spectrometry was used for quantification. Under nearly all conditions, tenuazonic acid was the most extensively produced toxin. At 25 °C and with increasing incubation time all toxins were formed in high amounts by the two A. tenuissima strains on both substrates with comparable mycotoxin profiles. However, for some of the toxins, stagnation or a decrease in production was observed from day 7 to 14. As opposed to the A. tenuissima strains, the A. infectoria strain only produced low amounts of ATs, but high concentrations of stemphyltoxin III. The results provide an essential insight into the quantitative in vitro AT formation under different environmental conditions, potentially transferable to different field and storage conditions. PMID:27869760

  11. Co-existence of Fisheries and Marine Renewable Energy: The Spotlight on Fishers and Fishers' Knowledge (FK)

    Science.gov (United States)

    Campbell, M. S.; Ashley, M.; De Groot, J.; Rodwell, L.

    2016-02-01

    As an emerging industry, Marine Renewable Energy (MRE) is expected to play a major contributory role if the UK is to successfully reach it's desired target of renewable energy production by 2020. However, due to the competing objectives and priorities of MRE and other industries, for example fisheries, and in the delivering of conservation measures, the demand for space within our marine landscape is increasing, and interactions are inevitable. A semi structured interview was conducted with forty fishers across the UK to elicit further information on the challenges, barriers to progress and priority issues these fishers face in relation to MRE development. The questionnaire also included a fisher assessment of the mitigation agenda developed by de Groot et al. (2014) under the Natural Environment Research Council Marine Renewable Energy Knowledge Exchange Programme ( NERC MREKEP). Qualitative data were extracted and analysed using the text analysis software NVivo8. Fishers identified barriers to progress, and in order of the most important themes included; policy, consultation, trust, lack of knowledge, true representation of all fishers, science vs. fisher observation mismatch and timescales. Priority issues identified in order of importance were; displacement or loss of access, cable disturbance, timings of installation/repairs, effects on the seabed and specifically offshore windfarm (OWF) sitting. The consultation process caused discontent among all fishers interviewed. In relation to working towards a collaborative mitigation agenda, fishers highlighted issues of trust in relation to; trans-boundary management, data management and the consultation process. At all stages of the research, the response rate of the importance of gathering fishers' knowledge (FK) was high. Fishers underlined the importance of this data source in assessing the impacts of MRE on the sectors of the UK fleet. Thus, although at an early stage of development, an initial framework for the collection and application of FK is presented and further work on data needs highlighted.

  12. From the Margins to the Spotlight: Diverse Deaf and Hard of Hearing Student Populations and Standardized Assessment Accessibility.

    Science.gov (United States)

    Cawthon, Stephanie

    2015-01-01

    Designing assessments and tests is one of the more challenging aspects of creating an accessible learning environment for students who are deaf or hard of hearing (DHH), particularly for deaf students with a disability (DWD). Standardized assessments are a key mechanism by which the educational system in the United States measures student progress, teacher effectiveness, and the impact of school reform. The diversity of student characteristics within DHH and DWD populations is only now becoming visible in the research literature relating to standardized assessments and their use in large-scale accountability reforms. The purpose of this article is to explore the theoretical frameworks surrounding assessment policy and practice, current research related to standardized assessment and students who are DHH and DWD, and potential implications for practice within both the assessment and instruction contexts.

  13. 21st Century-Based Soft Skills: Spotlight on Non-Cognitive Skills in a Cognitive-Laden Dentistry Program

    Science.gov (United States)

    Quieng, Marjorie C.; Lim, Pearly P.; Lucas, Maria Rita D.

    2015-01-01

    Teaching and learning in the 21st century aims to produce students proficient in content knowledge, specific abilities, literacy, numeracy, and technology uses. From these 21st century skills, soft skills were delineated from these learning outcomes; and defined as intra- and interpersonal skills vital for personal development, social…

  14. A systematic review of viral infections associated with oral involvement in cancer patients : a spotlight on Herpesviridea

    NARCIS (Netherlands)

    Elad, Sharon; Zadik, Yehuda; Hewson, Ian; Hovan, Allan; Correa, M. Elvira P.; Logan, Richard; Elting, Linda S.; Spijkervet, Fred K. L.; Brennan, Michael T.

    Our aim was to evaluate the literature for the prevalence of and interventions for oral viral infections and, based on scientific evidence, point to effective treatment protocols. Quality of life (QOL) and economic impact were assessed if available in the articles reviewed. Our search of the English

  15. Spotlight on bevacizumab and its potential in the treatment of malignant pleural mesothelioma: the evidence to date

    Directory of Open Access Journals (Sweden)

    Levin PA

    2017-04-01

    Full Text Available Pavel A Levin,1 Jonathan E Dowell1,2 1Division of Hematology/Oncology, University of Texas Southwestern Medical Center, 2Section of Hematology/Oncology, Veteran Affairs North Texas Health Care System, Dallas, TX, USA Abstract: Malignant pleural mesothelioma (MPM is a rare, but aggressive cancer. Surgery and radiation offer limited benefit, and systemic chemotherapy remains the primary treatment modality for the majority of patients. Vascular endothelial growth factor (VEGF and its receptor have been recognized as important players in the biology of this disease. Bevacizumab is a monoclonal antibody that binds VEGF and blocks its interaction with the VEGF receptor. Recent studies have shown benefit with the addition of bevacizumab to the combination of cisplatin and pemetrexed in MPM. This combination is now included in the National Comprehensive Cancer Network guidelines (with a category 2A recommendation as a possible first-line treatment for unresectable MPM in appropriately selected patients. This review discusses the rationale behind the use of bevacizumab in MPM, as well as summarizes the pharmacology, efficacy, safety, and toxicity of bevacizumab across multiple trials. The use of small-molecule inhibitors of angiogenesis in the treatment of MPM is also discussed. Keywords: angiogenesis, monoclonal antibody, VEGF

  16. Grantee Spotlight: Manuel L. Penichet, M.D., Ph.D. - Reprogramming the Immune System to Kill Cancer

    Science.gov (United States)

    Dr. Manuel L. Penichet, former CURE K01 trainee and NCI R01 grantee, aims to genetically engineer antibodies that can be used to directly target and eliminate cancer cells and also stimulate the body’s immune system to fight and destroy cancer.

  17. In the Spotlight of Misperception: Japanese Science Fiction Vis-à-vis Western Science Fiction Set in Japan

    Directory of Open Access Journals (Sweden)

    Baryon Tensor Posadas

    2000-06-01

    Full Text Available In 1984, William Gibson published a novel that began new traditions in science fiction writing —Neuromancer. the novel won a hat-trick of all three of the major science fiction awards: The Hugo, Nebula, and the Philip K. Dick. The opening chapter was set in Chiba prefecture, a large coastal region east of the capital Tokyo with the line "The sky above the port was the color of television turned to a dead channel" (Gibson 1. It was the centerpiece of the cyberpunk movement characterized by a mix of high technology in the fields of computer networking and biomechanical interface and urban street life (Sterling xi.Yet despite its opening scenes being set in Tokyo, Gibson at that time had never set foot in Japan. Furthermore, practically all of Gibson's novels—Neuromancer (1984, Count Zero (1986, Mona Liza Overdrive (1988, Virtual Light (1991, and Idoru (1995 along with several of his short stories, have dealt with Japan in varying degrees, wether as a setting or by involving Japanese social system sush as the yakuza and the zaibatsu system of corporate management as atmospheric elements.Another impetus came from Delia Aguilar's study on Filipino housewives and the politics of gender. This study reveals that " . . . in the private space of the family as the major mechanism for the reproduction of social relations, women are at once validated and oppressed, a process that is powerfully mediated by the maternal ideology of which women are the foremost proponents." This maternal ideology shapes Filipino women's idea of motherhood that sees devotion to children, self-sacrifice, and care giving as the essence of motherhood, allowing them to embrace oppression and subordination. In this context, the interrogation of maternal ideology in Philippine literature is important to the overall feminist movement. Women writers who have freed themselves from the mystifying notions of motherhood may have been inspired to represent women in their works differently.This paper clearly validates such assumption. Writers like Liwayway Arceo, Genoveva Edroza-Matute, Fanny Garcia, Lualhati Bautista, Lilia Quindoza-Santiago, and Luna Sicat-Cleto, as this reading of some of their works reveals, challenge the dominant maternal ideology by re-imagining motherhood. Without wholly rejecting the traditional notion of motherhood (with the exception of Luna Sicat-Cleto who questions the so called "essence" of motherhood, these writers interrogate the idealization of motherhood, question some of the fundamental assumptions of the dominant maternal ideology and represent women as mothers who are nurturing and caring just like the typical image of a Filipino mother, but who are not happy with confinement in the private domestic space. This radical representation of motherhood is, therefore, a welcome development in the present development of feminist discourse in the Philippines.

  18. The Future of Futures

    DEFF Research Database (Denmark)

    Frankel, Christian; Ossandón, José

    2013-01-01

    Review of Elena Esposito: The Future of Futures. The Time of Money in Financing and Society Cheltenham. Edward Elgar, 2011.......Review of Elena Esposito: The Future of Futures. The Time of Money in Financing and Society Cheltenham. Edward Elgar, 2011....

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human gene · Elena V Antontseva Marina Yu Matveeva Natalia P Bondar Elena V Kashina Elena Yu Leberfarb Leonid O Bryzgalov Polina A Gervas Anastasia A Ponomareva Nadezhda V Cherdyntseva Yury L Orlov Tatiana I Merkulova.

  20. La mujer en la gestión del agua, en el contexto de la junta regional de agua potable de Manglaralto, de la Península de Santa Elena, desde el año 2012.

    OpenAIRE

    Endara Izquierdo, Elsie Carmela

    2014-01-01

    This research was conducted to answer the question: Women Drinking Water Board Manglaralto an active role in political decision making in the control and management of drinking water have ?. For which a description of Manglaralto which consist aspects socio performed economic, population and access to basic services. Este trabajo de investigación se realizó para responder a la pregunta: ¿Tienen las mujeres de la Junta de Agua Potable de Manglaralto, un rol activo en la toma de decisión ...

  1. Estudio del polvo de vidrio obtenido de la molienda de botellas recicladas en la provincia de Santa Elena, como sustituto parcial del cemento en el hormigón

    Directory of Open Access Journals (Sweden)

    Juan Garcés Vargas

    2016-12-01

      The present study consists in reusing glass bottle wastes by crushing and grounding them into a fineness that allows the partial substitute of cement in the concrete. This is because when glass has been finely grounded to a micron size, it acts as a high reactivity pozzolana. Cement is the main component for producing concrete; it is also the one that causes the highest impact to the environment because the clinker production requires high energy consumption.  There are studies to diminish the energy consumption, such as the substitution of fossil fuel for high calorific power residues, or by diminishing or substituting cement in construction without affecting its quality, and improving its mechanical properties. That is obtained by using materials such as flying ashes, blast furnace slags or silica fume, and the use of recycled materials, among others.  The use of recycled material in concrete supposes a double benefit: on the one hand wastes are diminished and, on the other hand, the mechanical properties of concrete can be improved.  That said, glass is a material that due to its physical and chemical properties, is an ideal candidate for recycling it in high percentage.

  2. Análisis de los sistemas de gestión del conocimiento en la empacadora grupo Granmar: división laboratorio de larvas Semacua S.A de la provincia de Santa Elena – Ecuador

    Directory of Open Access Journals (Sweden)

    Mónica Jaramillo

    2016-11-01

    The management of intangible assets that generate value for the organization are those that have to do with the processes related to the transmission of knowledge, for this reason a model of knowledge management is designed, with the use of ICT tools to streamline the process and improve the use of the access mechanisms and finding information, since those operating not currently guarantee a correct transfer of information or adequate learning, growing importance as a new production factor has turned development of technologies , methodologies and strategies to become one of the main priorities of organizations in the knowledge society. It is known that the market is increasingly competitive, which demands greater innovation in products, therefore, knowledge must be developed and assimilated more and more quickly, which is achieved by having an automated process that meets policies security for information processing. The management model is aimed at people who apply technology focused knowledge sharing, because the companies take full advantage of their knowledge, repeat not waste time tasks or perform them to share knowledge in the organization.

  3. Review: Dorothée Ninck Gbeassor, Heidi Schär Sall, David Signer, Daniel Stutz & Elena Wertli (1999). Überlebenskunst in Übergangswelten: ethnopsychologische Betreuung von Asylsuchenden

    OpenAIRE

    Hegner, Victoria

    2002-01-01

    Das vorliegende Buch ist das erste von bisher zwei erschienenen Büchern des Ethnologisch-Psychologischen Zentrums in Zürich. In der Einrichtung der Asyl-Organisation für den Kanton Zürich finden Asylsuchende in schweren Krisen stationäre oder ambulante Betreuung. Die Flüchtlinge, die hierher kommen, sind dem Krieg, der Folter und/oder dem Gefängnis in der einstigen Heimat physisch entkommen. Die Migration und allmähliche Ankunft im kulturell und sozial Neuen stellt für sie jedoch eine Überfor...

  4. INCIDENCIA DE LA INVESTIGACIÓN BIBLIOGRÁFICA EN EL APRENDIZAJE EN ESTUDIANTES DEL NIVEL BÁSICO DE LA CARRERA ADMINISTRACIÓN DE EMPRESAS DE UNIVERSIDAD ESTATAL PENÍNSULA DE SANTA ELENA

    Directory of Open Access Journals (Sweden)

    William Caiche Rosales

    2017-01-01

    Full Text Available El desarrollo de hábitos de lectura en estudiantes de educación superior representa un verdadero reto para el docente, sobre todo por que dicha práctica impulsa la capacidad de analizar y de emitir juicios de valor y consolida las bases cognitivas que recibe en el proceso de aprendizaje, Se ha identificado que, el estudiante de Administración de empresas en el desarrollo de actividades académicas cita referencias bibliográficas que, de manera mayoritaria provienen de consultas de bajo nivel académico, por otro lado, es escaso el número de referencias que incluye, esta situación limita el aprendizaje, y se refleja en los resultados de evaluación del proceso. Este trabajo plantea como objetivo determinar el efecto que tiene en el aprendizaje la implementación de una guía de investigación bibliográfica para el nivel básico en los estudiantes de la Carrera Administración de Empresas de la UPSE; para el efecto se recurre a un diseño de investigación explicativo que a través de la comparación del antes y el después permita verificar el logro de tal objetivo.   ABSTRACT The development of habits of reading in students of higher education represents a real challenge for the teacher, especially because this practice promotes the ability to analyse and make value judgments and strengthens cognitive bases in the learning process, has been identified, the student of business management in the development of academic activities cited references thatmajority way come from queries of low academic level, on the other hand, numbers, including is little, this situation limits learning, and it is reflected in the results of the process evaluation. This work is aimed at determining the effect that has on learning the implementation of a guide of bibliographic research for the basic level students of the business administration career of the UPSE; the effect is relied on to an explanatory research design which through a comparison of the before and then allow to verify the achievement of such a goal.

  5. Elaboración de hormigones que minimicen el impacto al ambiente, empleando neumáticos usados de vehículos livianos y pesados, en la provincia de Santa Elena

    OpenAIRE

    Armando Saltos

    2016-01-01

    Las llantas usadas son consideradas un foco de riesgo ambiental y sanitario a nivel mundial, por ejemplo en Ecuador se desecha al año, según la Corporación para la Promoción Proactiva de Inversiones (INVEC), cerca de 2,4 millones de neumáticos de diversos tipos, lo que equivale a 55.000 toneladas. La menor parte de ellos son reutilizados para el reencauchado, pero la gran mayoría es incinerada o depositada en basureros a cielo abierto, lo que supone una amenaza contra el medio ambiente y ries...

  6. Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection--Liver: The "Musketeer" in the Spotlight.

    Science.gov (United States)

    Ballestri, Stefano; Nascimbeni, Fabio; Romagnoli, Dante; Baldelli, Enrica; Targher, Giovanni; Lonardo, Amedeo

    2016-03-09

    The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of fatty (simple steatosis and steatohepatitis) and non-fatty liver changes (NASH-cirrhosis with or without hepatocellular carcinoma (HCC)) that are commonly observed among individuals with multiple metabolic derangements, notably including visceral obesity, IR and T2D. Hepatitis C virus (HCV) infection is also often associated with both hepatic steatosis and features of a specific HCV-associated dysmetabolic syndrome. In recent years, the key role of the steatotic liver in the development of IR and T2D has been increasingly recognized. Thus, in this comprehensive review we summarize the rapidly expanding body of evidence that links T2D with NAFLD and HCV infection. For each of these two liver diseases with systemic manifestations, we discuss the epidemiological burden, the pathophysiologic mechanisms and the clinical implications. To date, substantial evidence suggests that NAFLD and HCV play a key role in T2D development and that the interaction of T2D with liver disease may result in a "vicious circle", eventually leading to an increased risk of all-cause mortality and liver-related and cardiovascular complications. Preliminary evidence also suggests that improvement of NAFLD is associated with a decreased incidence of T2D. Similarly, the prevention of T2D following HCV eradication in the era of direct-acting antiviral agents is a biologically plausible result. However, additional studies are required for further clarification of mechanisms involved.

  7. Going beyond "First Impressions": Jane Austen on the spotlightDOI:10.5007/2175-8026.2010n59p101

    Directory of Open Access Journals (Sweden)

    Carla Alexandra Ferreira

    2010-03-01

    Full Text Available The last decades has seen a proliferation of Jane Austen’s novels for television and cinema. Despite being an important movement for the popularity of her literary work that has also brought some problems for a serious understanding of Austen’s literary project. The purpose of this essay is to point out the need of considering the changes, preferences and omissions, apparently not very important or carried out because of some demands of the translation from a novel to the cinema, that occur when her work is revisited. We will try to show some choices made in the transference from her novels to film may erase part of the writer’s fictional project which is among other things to portray women’s role in the nineteenth century patriarchal English society and try to change women’s condition of invisibility that had been created and spread since Enlightenment. In order to illustrate our point the 2005 version of Pride and Prejudice for the cinema will be used.

  8. Antimicrobial Peptides: a promising class of antimicrobial compounds against BWA and multi-drug resistant bacteria: in the spotlight: the lactoferrin chimera

    NARCIS (Netherlands)

    Bikker, F.J.; Sijbrandij, T.; Nazmi, K.; Bolscher, J.G.M.; Veerman, E.C.I.; Jansen, H-J.

    2014-01-01

    Anti-Microbial Peptides (AMPs) are part of the innate immune defense system and considered as promising lead compounds for the development of novel anti-bacterial agents. In general, AMPs are simple, short peptides with broad-spectrum activity against Gram-negative and Gram-positive bacteria, fungi,

  9. Spotlight on crizotinib in the first-line treatment of ALK-positive advanced non-small-cell lung cancer: patients selection and perspectives

    Directory of Open Access Journals (Sweden)

    Giroux Leprieur E

    2016-06-01

    Full Text Available Etienne Giroux Leprieur,1,2 Vincent Fallet,3,4 Jacques Cadranel,3,4 Marie Wislez3,4 1Respiratory Diseases and Thoracic Oncology Department, APHP-Ambroise Paré Hospital, Boulogne-Billancourt, France; 2EA4340 Laboratory, UVSQ, Paris-Saclay University, France; 3Respiratory Diseases Department, APHP – Tenon Hospital, Paris, France; 4Sorbonne University, GRC 04, UPMC Univ Paris 06, France Abstract: Around 4% of advanced non-small-cell lung cancers (NSCLCs have an ALK rearrangement at the time of diagnosis. This molecular feature is more frequent in young patients, with no/light smoking habit and with adenocarcinoma pathological subtype. Crizotinib is a tyrosine kinase inhibitor, targeting ALK, ROS1, RON, and MET. The preclinical efficacy results led to a fast-track clinical development. The US Food and Drug Administration (FDA approval was achieved after the Phase I clinical trial in 2011 in ALK-rearranged advanced NSCLC progressing after a first-line treatment. In 2013, the randomized Phase III trial PROFILE-1007 confirmed the efficacy of crizotinib in ALK-rearranged NSCLC, compared to cytotoxic chemotherapy, in second-line setting or more. In 2014, the PROFILE-1014 trial showed the superiority of crizotinib in the first-line setting compared to the pemetrexed platinum doublet chemotherapy. The response rate was 74%, and the progression-free survival was 10.9 months with crizotinib. Based on these results, crizotinib received approval from the FDA and European Medicines Agency for first-line treatment of ALK-rearranged NSCLC. The various molecular mechanisms at the time of the progression (ALK mutations or amplification, ALK-independent mechanisms encourage performing re-biopsy at the time of progression under crizotinib. The best treatment strategy at the progression (crizotinib continuation beyond progression, switch to second-generation tyrosine kinase inhibitors, or cytotoxic chemotherapy depends on the phenotype of the progression, the molecular status, and the physical condition of the patient. Keywords: ALK rearrangement, crizotinib, non-small-cell lung carcinoma

  10. Relocation of the Hambach railway. Construction work. Implementation of a major project in the public spotlight; Verlegung der Hambachbahn. Bauausfuehrung. Realisierung eines Grossprojektes im Fokus der Oeffentlichkeit

    Energy Technology Data Exchange (ETDEWEB)

    Waschke, Karsten; Luchtenberg, Michael [RWE Power AG, Koeln (Germany). Bauplanung und -genehmigung

    2011-11-15

    A 9 km-long section of today's Hambach railway line is located in the future extraction area of the Hambach mine. In view of the advancing opencast mine, the Company-owned railway must be moved from the extraction area. The construction measures for the relocation of the Hambach railway have been executed since 2008. Besides cost, progress and quality control, the extensive information of the population and the interfaces to the simultaneous relocation of the autobahn A4 and federal highway B477 and to the advancing mine pose particular challenges. On the whole, the project is progressing according to plan and secures future lignite production in the Hambach mine and the supply of the lignite-fired power plants and factories along the North-South railway.

  11. The rise of photoresponsive protein technologies applications in vivo: a spotlight on zebrafish developmental and cell biology [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Renee Wei-Yan Chow

    2017-04-01

    Full Text Available The zebrafish (Danio rerio is a powerful vertebrate model to study cellular and developmental processes in vivo. The optical clarity and their amenability to genetic manipulation make zebrafish a model of choice when it comes to applying optical techniques involving genetically encoded photoresponsive protein technologies. In recent years, a number of fluorescent protein and optogenetic technologies have emerged that allow new ways to visualize, quantify, and perturb developmental dynamics. Here, we explain the principles of these new tools and describe some of their representative applications in zebrafish.

  12. Molecular Genetics and Genotype-Based Estimation of BH4-Responsiveness in Serbian PKU Patients: Spotlight on Phenotypic Implications of p.L48S.

    Science.gov (United States)

    Djordjevic, Maja; Klaassen, Kristel; Sarajlija, Adrijan; Tosic, Natasa; Zukic, Branka; Kecman, Bozica; Ugrin, Milena; Spasovski, Vesna; Pavlovic, Sonja; Stojiljkovic, Maja

    2013-01-01

    Phenylketonuria (PKU) is caused by mutations in the gene encoding phenylalanine hydroxylase (PAH) enzyme. Here, we report the updated spectrum of PAH mutations in 61 Serbian PKU patients. By using both DGGE/DNA sequencing and PCR-RFLP, we identified 26 disease-causing mutations (detection rate 99%). The most frequent ones were p.L48S (31%), p.R408W (16.4%), p.P281L (6%), p.E390G (5.2%), and p.I306V (5.2%). Homozygosity value indicated high heterogeneity of Serbian population.To overcome possible pitfalls of patients' phenotypic classification, we used two parameters: pretreatment/maximal phenylalanine blood concentration and Phe tolerance. The two phenotypes did not match only for patients with p.L48S. Therefore, we used Mann-Whitney statistical test to compare pretreatment/maximal blood Phe concentration and Phe tolerance detected in patients with p.[L48S];[null] and p.[missense];[null] genotypes. For patients with p.L48S, our results implied that Phe tolerance is a better parameter for phenotypic classification. Also, Fisher's exact test was used to compare p.L48S effect on phenotype of homozygous and functionally hemizygous patients. Our findings showed that effect of p.L48S was altered in functional hemizygotes. Moreover, phenotypic inconsistency found in homozygotes suggested that interallelic complementation and/or additional factors play a role in genotype-phenotype correlation.Since BH4-supplementation therapy is not available in Serbia, we made the first estimation of its potential benefit based on patients' genotypes. In the analyzed cohort, the total frequency of BH4-responsive mutations was 52.6%. Furthermore, we found a significant number of genotypes (26.2% BH4-responsive and 51% probably BH4-responsive) that may respond to BH4 therapy. This led us to a conclusion that BH4-supplementation therapy could bring benefit to Serbian PKU patients.

  13. Data Use "Multi-State" Spotlight: Using Data Fidelity Tools to Improve Data Quality. Transforming State Systems to Improve Outcomes for Children with Disabilities

    Science.gov (United States)

    Ruedel, Kristin; Nelson, Gena; Bailey, Tessie

    2018-01-01

    To evaluate interim progress toward the State-identified Measurable Result (SIMR), states require access to high-quality data from local education agencies (LEAs) and early intervention service providers. In a review of 2017 Phase III State Systemic Improvement Plans (SSIP), 43 Part C states noted limitations or concerns related to data and…

  14. VA health service utilization for homeless and low-income Veterans: a spotlight on the VA Supportive Housing (VASH) program in greater Los Angeles.

    Science.gov (United States)

    Gabrielian, Sonya; Yuan, Anita H; Andersen, Ronald M; Rubenstein, Lisa V; Gelberg, Lillian

    2014-05-01

    The US Department of Housing and Urban Development (HUD)-VA Supportive Housing (VASH) program-the VA's Housing First effort-is central to efforts to end Veteran homelessness. Yet, little is known about health care utilization patterns associated with achieving HUD-VASH housing. We compare health service utilization at the VA Greater Los Angeles among: (1) formerly homeless Veterans housed through HUD-VASH (HUD-VASH Veterans); (2) currently homeless Veterans; (3) housed, low-income Veterans not in HUD-VASH; and (4) housed, not low-income Veterans. We performed a secondary database analysis of Veterans (n=62,459) who received VA Greater Los Angeles care between October 1, 2010 and September 30, 2011. We described medical/surgical and mental health utilization [inpatient, outpatient, and emergency department (ED)]. We controlled for demographics, need, and primary care use in regression analyses of utilization data by housing and income status. HUD-VASH Veterans had more inpatient, outpatient, and ED use than currently homeless Veterans. Adjusting for demographics and need, HUD-VASH Veterans and the low-income housed Veterans had similar likelihoods of medical/surgical inpatient and outpatient utilization, compared with the housed, not low-income group. Adjusting first for demographics and need (model 1), then also for primary care use (model 2), HUD-VASH Veterans had the greatest decrease in incident rates of specialty medical/surgical, mental health, and ED care from models 1 to 2, becoming similar to the currently homeless, compared with the housed, not low-income group. Our findings suggest that currently homeless Veterans underuse health care relative to housed Veterans. HUD-VASH may address this disparity by providing housing and linkages to primary care.

  15. Spotlight on once-monthly long-acting injectable aripiprazole and its potential as maintenance treatment for bipolar I disorder in adult patients

    Directory of Open Access Journals (Sweden)

    Torres-Llenza V

    2018-01-01

    Full Text Available Vanessa Torres-Llenza, Pooja Lakshmin, Daniel Z Lieberman Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, Washington, DC, USA Abstract: The lack of long-term medication adherence is a challenge in the treatment of bipolar disorder, particularly during the maintenance phase when symptoms are less prominent. The rate of nonadherence is ~20%–60% depending on how strict a definition is used. Nonadherence worsens the course of bipolar disorder and can add hundreds of thousands of dollars to the lifetime cost of treating the illness. Long-acting injectable (LAI medication is an attractive alternative to daily dosing of oral medication, especially among patients who are ambivalent about treatment. The purpose of this paper is to review the evidence for the safety and efficacy of LAI aripiprazole, which was recently approved for the treatment of bipolar disorder. The approval was based on a single double-blind, placebo-controlled, multisite trial that recruited participants from 103 sites in 7 countries. A total of 731 participants with bipolar disorder were enrolled in the study. Out of that total, 266 were successfully stabilized on LAI aripiprazole and entered the randomization phase. Treatment-emergent adverse events were, for the most part, mild to moderate. Akathisia was the most common adverse event, which, combined with restlessness, was experienced by 23% of the sample. At the end of the 52-week study period, nearly twice as many LAI-treated participants remained stable compared to those treated with placebo. Stability during the maintenance phase is arguably the most important goal of treatment. It is during this period of relative freedom from symptoms that patients are able to build a meaningful and satisfying life. The availability of a new treatment agent, particularly one that has the potential to enhance long-term adherence, is a welcome development. Keywords: antipsychotic, adherence, partial agonist, mood stabilizer, review

  16. The associations between domain-specific sedentary behaviours and dietary habits in European adults: a cross-sectional analysis of the SPOTLIGHT survey

    Directory of Open Access Journals (Sweden)

    Sofie Compernolle

    2016-10-01

    Full Text Available Abstract Background Sedentary behaviour has been associated with obesity and related chronic diseases. Disentangling the nature of this association is complicated due to interactions with other lifestyle factors, such as dietary habits, yet limited research has investigated the relation between domain-specific sedentary behaviours and dietary habits in adults. The aim of this paper was to examine the association between domain-specific sedentary behaviours and dietary habits in adults and to test the moderating effect of age and gender on this association. Methods A total of 6,037 participants from five urban regions in Europe completed an online survey, of which 6,001 were included in the analyses. Multilevel mixed-effects logistic regression analyses were used to examine main associations and interaction effects. Results All domain-specific sedentary behaviours, except transport-related sitting time, were significantly related to dietary habits. In general, having a higher sitting time was related to having less healthy dietary habits, especially for television viewing. Gender did not moderate any of the relations, and age was only a significant moderator in the relation between other leisure sitting time and alcohol consumption. Conclusion Domain-specific sitting behaviours were related to unhealthy dietary behaviours. However, the small effect sizes suggest that individual level behavioural interventions focusing on sedentary behaviour will not be sufficient to improve dietary habits. The fact that almost none of the associations were moderated by age or gender suggests that these associations, and possibly also the effects of interventions targeting both behaviours, may hold across age and gender groups.

  17. The associations between domain-specific sedentary behaviours and dietary habits in European adults: a cross-sectional analysis of the SPOTLIGHT survey.

    Science.gov (United States)

    Compernolle, Sofie; De Cocker, Katrien; Teixeira, Pedro J; Oppert, Jean-Michel; Roda, Célina; Mackenbach, Joreintje D; Lakerveld, Jeroen; McKee, Martin; Glonti, Ketevan; Rutter, Harry; Bardos, Helga; Cardon, Greet; De Bourdeaudhuij, Ilse

    2016-10-06

    Sedentary behaviour has been associated with obesity and related chronic diseases. Disentangling the nature of this association is complicated due to interactions with other lifestyle factors, such as dietary habits, yet limited research has investigated the relation between domain-specific sedentary behaviours and dietary habits in adults. The aim of this paper was to examine the association between domain-specific sedentary behaviours and dietary habits in adults and to test the moderating effect of age and gender on this association. A total of 6,037 participants from five urban regions in Europe completed an online survey, of which 6,001 were included in the analyses. Multilevel mixed-effects logistic regression analyses were used to examine main associations and interaction effects. All domain-specific sedentary behaviours, except transport-related sitting time, were significantly related to dietary habits. In general, having a higher sitting time was related to having less healthy dietary habits, especially for television viewing. Gender did not moderate any of the relations, and age was only a significant moderator in the relation between other leisure sitting time and alcohol consumption. Domain-specific sitting behaviours were related to unhealthy dietary behaviours. However, the small effect sizes suggest that individual level behavioural interventions focusing on sedentary behaviour will not be sufficient to improve dietary habits. The fact that almost none of the associations were moderated by age or gender suggests that these associations, and possibly also the effects of interventions targeting both behaviours, may hold across age and gender groups.

  18. Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection—Liver: The “Musketeer” in the Spotlight

    Science.gov (United States)

    Ballestri, Stefano; Nascimbeni, Fabio; Romagnoli, Dante; Baldelli, Enrica; Targher, Giovanni; Lonardo, Amedeo

    2016-01-01

    The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of fatty (simple steatosis and steatohepatitis) and non-fatty liver changes (NASH-cirrhosis with or without hepatocellular carcinoma (HCC)) that are commonly observed among individuals with multiple metabolic derangements, notably including visceral obesity, IR and T2D. Hepatitis C virus (HCV) infection is also often associated with both hepatic steatosis and features of a specific HCV-associated dysmetabolic syndrome. In recent years, the key role of the steatotic liver in the development of IR and T2D has been increasingly recognized. Thus, in this comprehensive review we summarize the rapidly expanding body of evidence that links T2D with NAFLD and HCV infection. For each of these two liver diseases with systemic manifestations, we discuss the epidemiological burden, the pathophysiologic mechanisms and the clinical implications. To date, substantial evidence suggests that NAFLD and HCV play a key role in T2D development and that the interaction of T2D with liver disease may result in a “vicious circle”, eventually leading to an increased risk of all-cause mortality and liver-related and cardiovascular complications. Preliminary evidence also suggests that improvement of NAFLD is associated with a decreased incidence of T2D. Similarly, the prevention of T2D following HCV eradication in the era of direct-acting antiviral agents is a biologically plausible result. However, additional studies are required for further clarification of mechanisms involved. PMID:27005620

  19. Spotlight on equality of employment opportunities: A qualitative study of job seeking experiences of graduating nurses and physiotherapists from black and minority ethnic backgrounds.

    Science.gov (United States)

    Hammond, John; Marshall-Lucette, Sylvie; Davies, Nigel; Ross, Fiona; Harris, Ruth

    2017-09-01

    There is growing attention in the UK and internationally to the representation of black and minority ethnic groups in healthcare education and the workplace. Although the NHS workforce is very diverse, ethnic minorities are unevenly spread across occupations, and considerably underrepresented in senior positions. Previous research has highlighted that this inequality also exists at junior levels with newly qualified nurses from non-White/British ethnic groups being less likely to get a job at graduation than their White/British colleagues. Although there is better national data on the scale of inequalities in the healthcare workforce, there is a gap in our understanding about the experience of job seeking, and the factors that influence disadvantage in nursing and other professions such as physiotherapy. This qualitative study seeks to fill that gap and explores the experience of student nurses (n=12) and physiotherapists (n=6) throughout their education and during the first 6-months post qualification to identify key experiences and milestones relating to successful employment particularly focusing on the perspectives from different ethnic groups. Participants were purposively sampled from one university to ensure diversity in ethnic group, age and gender. Using a phenomenological approach, in-depth semi-structured interviews were conducted at course completion and 6 months later. Two main themes were identified. The 'proactive self' ('It's up to me') theme included perceptions of employment success being due to student proactivity and resilience; qualities valued by employers. The second theme described the need to 'fit in' with organisational culture. Graduates described accommodating strategies where they modified aspects of their identity (clothing, cultural markers) to fit in. At one extreme, rather than fitting in, participants from minority ethnic backgrounds avoided applying to certain hospitals due to perceptions of discriminatory cultures, 'I wouldn't apply there 'cos you know, it's not really an ethnic hospital'. In contrast, some participants recognised that other graduates (usually white) did not need to change and aspects of their identity brought unsolicited rewards 'if your face fits then the barriers are reduced'. The findings indicate that success in getting work is perceived as determined by individual factors, and fitting in is enabled by strategies adopted by the individual rather than the workplace. Demands for change are more acute for graduates from black and minority ethnic backgrounds. This is an issue for healthcare organisations seeking to be inclusive and challenges employers and educators to acknowledge inequalities and take action to address them. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Spotlight on fluticasone furoate/vilanterol trifenatate for the once-daily treatment of asthma: design, development and place in therapy

    Directory of Open Access Journals (Sweden)

    Albertson TE

    2016-12-01

    Full Text Available Timothy E Albertson,1–3 Samuel W Bullick,1,3 Michael Schivo,1 Mark E Sutter2,3 1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, 2Department of Emergency Medicine, School of Medicine, UC Davis, Sacramento, 3Department of Medicine, Veterans Administration Northern California Health Care System, Mather, CA, USA Abstract: The use of inhaled corticosteroids (ICSs plays a key role in the treatment of asthmatic patients, and international guidelines have designated ICSs as an early maintenance therapy in controlling asthma symptoms. When asthmatic patients remain symptomatic on ICSs, one common option is to add a long-acting beta2 agonist (LABA to the maintenance treatment. Fixed combination inhalers that contain both an ICS and a LABA have been popular for both chronic obstructive pulmonary disease (COPD and asthma. Historically, these inhalers have been dosed twice daily. However, currently, there is a once-daily combination therapy with the ICS fluticasone furoate (FF and the LABA vilanterol trifenatate (VI with indications for use in both COPD and asthma. This dry powder inhaler (DPI comes in two doses of FF (100 or 200 µg both combined with VI (25 µg. This article reviews the clinical trial data for FF, VI and FF/VI combination inhalers and documents the efficacy and safety of once-daily inhaled maintenance therapy by DPI in asthmatic patients. Keywords: fluticasone furoate/vilanterol trifenatate, asthma, long-acting beta2 agonist, inhaled corticosteroid, combined inhaler, persistent asthma, dry powder inhaler  

  1. The evolution of the Italian EPR system for the management of household Waste Electrical and Electronic Equipment (WEEE). Technical and economic performance in the spotlight.

    Science.gov (United States)

    Favot, Marinella; Veit, Raphael; Massarutto, Antonio

    2016-10-01

    In this paper we analyse the Italian collective system for the management of household Waste Electrical and Electronic Equipment (WEEE), and its evolution over time, following the European Directives on WEEE, which include the Extended Producer Responsibility (EPR). The analysis focuses on the technical and economic performance of WEEE compliance organisations (consortia), as they are the key players in the Italian EPR regime. Economic results have not usually been provided in previous studies, due to the lack of available data. This study overcomes this problem by accessing the financial statements for the years 2009-2014 of all consortia. The main conclusions of the study are: The Italian EPR system barely exceeded the technical target of the first WEEE Directive (4kg per capita). Improvements are necessary to achieve the target set for 2019 by the Recast Directive. The economic performance of the Italian EPR regime improved significantly over time. The fees charged per tonne of WEEE collected decreased by almost 43% from 652 Euro per tonne in 2009 to 374 Euro per tonne in 2014, while the fees per tonne put on the market (POM) were 134 Euro in 2009 and 104 Euro in 2014. The results prove the theory which states that, competing consortia use the learning effects to reduce the contribution fees for producers rather than to increase the quantity collected. Municipalities remain the most important actor in WEEE collection operations. Consortia compensate municipalities with a reimbursement that ranges between 28 and 38 Euros per tonne collected. These repayments cover only partially their costs. Additional studies should investigate their role. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. From Spotlight to Fluorescent Bulb: Aesthetic Dimensions of Personal, Practical Knowledge in an Actor Training to Be a High School Teacher

    Science.gov (United States)

    Dobson, Darrell

    2005-01-01

    This paper can be conceived as one story embedded in a second story, in which the "outer" narrative, involving the theoretical and methodological framework, is that of my search for a means of defining, articulating and implementing an aesthetic epistemology in both academic research and in teacher education/development (a search that is…

  3. LLRF beam results on the first year of ELENA’s commissioning with beam

    CERN Document Server

    Angoletta, Maria Elena; Molendijk, John; Sanchez Quesada, Jorge; CERN. Geneva. ATS Department

    2018-01-01

    CERN’s Extra Low ENergy Antiproton (ELENA) ring’s commissioning with beam started in earnest in March 2017. Ions from an H- source were injected in ELENA at low energy, although in a degraded way (lower voltage and intensity than planned) and with not constant reproducibility of the injection. From August 2017 onwards antiprotons from the AD were also injected in ELENA at high energy for up to three, weekly MD session. The 2017 ELENA commissioning run stopped on December 1st to allow the installation of the electron cooler. This note gives an overview of the successful operation carried out by the ELENA Low-Level RF (LLRF) during the first year of ELENA commissioning and of the main beam results obtained. Operation with H- ions and with antiprotons are considered, together with different operational settings and problems encountered. Hints on future deployment and commissioning steps are also provided.

  4. Your Radiologist Explains CT Colonography

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    Full Text Available ... Site Index A-Z Spotlight February is American Heart Month Recently posted: Carotid Intima-Media Thickness Test ... and for your attention! Spotlight February is American Heart Month Recently posted: Carotid Intima-Media Thickness Test ...

  5. Your Radiologist Explains Nuclear Medicine

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    Full Text Available ... Site Index A-Z Spotlight February is American Heart Month Recently posted: Carotid Intima-Media Thickness Test ... you for your time! Spotlight February is American Heart Month Recently posted: Carotid Intima-Media Thickness Test ...

  6. Your Radiologist Explains Magnetic Resonance Angiography (MRA)

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    Full Text Available ... Site Index A-Z Spotlight February is American Heart Month Recently posted: Carotid Intima-Media Thickness Test ... and for your attention! Spotlight February is American Heart Month Recently posted: Carotid Intima-Media Thickness Test ...

  7. Protein Replacement Therapy Shows Promise in Treating Rare Skin Disorder

    Science.gov (United States)

    ... Room Spotlight on Research Spotlight on Research Protein Replacement Therapy Shows Promise in Treating Rare Skin Disorder ... are under development. One promising approach involves protein replacement. Previous research has suggested that replacing the missing ...

  8. Adding a Vitamin D Supplement Likely Does Not Improve Knee Osteoarthritis

    Science.gov (United States)

    ... Spotlight on Research Spotlight on Research Adding a Vitamin D Supplement Likely Does Not Improve Knee Osteoarthritis By Colleen Labbe, M.S. | June 1, 2013 Vitamin D supplements likely do not improve symptoms of knee ...

  9. Cesarean Section: The Operation

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  10. Gestational Hypertension and Preeclampsia

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  11. Cesarean Section: Recovering After Surgery

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  12. At Least 39 Weeks

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  13. Exercise during Pregnancy

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  14. National Institute of Nursing Research

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    ... Management Resources Precision Medicine at NINR Research Highlights Data Science and Nursing Research Spotlight on End-of-Life ... Management Resources Precision Medicine at NINR Research Highlights Data Science and Nursing Research Spotlight on End-of-Life ...

  15. Frequently Asked Questions (Palliative Care: Conversations Matter)

    Science.gov (United States)

    ... Management Resources Precision Medicine at NINR Research Highlights Data Science and Nursing Research Spotlight on End-of-Life ... Management Resources Precision Medicine at NINR Research Highlights Data Science and Nursing Research Spotlight on End-of-Life ...

  16. Common Laundry Detergent Ingredient May Help Preserve Muscle Tissue After Severe Injury

    Science.gov (United States)

    ... Spotlight on Research Spotlight on Research Common Laundry Detergent Ingredient May Help Preserve Muscle Tissue After Severe ... 2013 A compound commonly found in household laundry detergents may help preserve muscle tissue after a severe ...

  17. Your Radiologist Explains Nuclear Medicine

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    Full Text Available ... Site Index A-Z Spotlight March is National Colorectal Cancer Awareness Month Recently posted: Video: The Basketball Game: ... you for your time! Spotlight March is National Colorectal Cancer Awareness Month Recently posted: Video: The Basketball Game: ...

  18. Chest X-Ray

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  19. Your Radiologist Explains CT Colonography

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    Full Text Available ... Site Index A-Z Spotlight March is National Colorectal Cancer Awareness Month Recently posted: Video: The Basketball Game: ... and for your attention! Spotlight March is National Colorectal Cancer Awareness Month Recently posted: Video: The Basketball Game: ...

  20. Your Radiologist Explains Magnetic Resonance Angiography (MRA)

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    Full Text Available ... Site Index A-Z Spotlight March is National Colorectal Cancer Awareness Month Recently posted: Video: The Basketball Game: ... and for your attention! Spotlight March is National Colorectal Cancer Awareness Month Recently posted: Video: The Basketball Game: ...