Electrophysiological study in the infraorbital nerve of the rat: Spontaneous and evoked activity

International Nuclear Information System (INIS)

AlbarracIn, A L; Farfan, F D; Felice, C J

2007-01-01

In this work we present some studies in the afferent nerve of the rat vibrissae. Studies on spontaneous activity (SA) in this sensorial system are of long data. Nevertheless, SA recordings in the nerve of a single vibrissa have not been made until present. In this work, we use an algorithm based on signal decomposition with Continuous Wavelet Transform (CWT) to analyse the discharges of two nerves. The action potentials of both nerves were detected and the firing rates were calculated. These results suggest that the firing rate of one vibrissa innervation is low considering that this nerve contains hundred of fibers. In addition, we present preliminary studies suggesting important effects of the hair shaft length in the afferent discharge during the vibrissae movements. The experiments consisted in recording the nerve activity after the vibrissae were sectioned at two different levels. The results showed important differences in the signal energy contents. It suggests that the hair shaft length would produce a differential activation of the mechanoreceptors located in the vibrissae follicle

Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal Networks

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Atsushi Usami

2008-01-01

Full Text Available Using functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimicked in vivo conditions, spontaneous activity was increased in active cell number and activity frequency. When ionic compositions were restored to the control conditions, the activity level returned to baseline, but the weighted spatial dispersion of active cells, as assessed by entropy-based metrics, did not. Thus, the networks can modify themselves by altering the internal structure of their correlated activity, even though they as a whole maintained the same level of activity in space and time.

Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells

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Yaniv, Yael; Ganesan, Ambhighainath; Yang, Dongmei; Ziman, Bruce D.; Lyashkov, Alexey E.; Levchenko, Andre; Zhang, Jin; Lakatta, Edward G.

2015-01-01

cAMP-PKA protein kinase is a key nodal signaling pathway that regulates a wide range of heart pacemaker cell functions. These functions are predicted to be involved in regulation of spontaneous action potential (AP) generation of these cells. Here we investigate if the kinetics and stoichiometry of increase in PKA activity match the increase in AP firing rate in response to β-adrenergic receptor (β-AR) stimulation or phosphodiesterase (PDE) inhibition, that alter the AP firing rate of heart sinoatrial pacemaker cells. In cultured adult rabbit pacemaker cells infected with an adenovirous expressing the FRET sensor AKAR3, the EC50 in response to graded increases in the intensity of β-AR stimulation (by Isoproterenol) the magnitude of the increases in PKA activity and the spontaneous AP firing rate were similar (0.4±0.1nM vs. 0.6±0.15nM, respectively). Moreover, the kinetics (t1/2) of the increases in PKA activity and spontaneous AP firing rate in response to β-AR stimulation or PDE inhibition were tightly linked. We characterized the system rate-limiting biochemical reactions by integrating these experimentally derived data into mechanistic-computational model. Model simulations predicted that phospholamban phosphorylation is a potent target of the increase in PKA activity that links to increase in spontaneous AP firing rate. In summary, the kinetics and stoichiometry of increases in PKA activity in response to a physiological (β-AR stimulation) or pharmacological (PDE inhibitor) stimuli match those of changes in the AP firing rate. Thus Ca2+-cAMP/PKA-dependent phosphorylation limits the rate and magnitude of increase in spontaneous AP firing rate. PMID:26241846

Neuronal activity in the isolated mouse spinal cord during spontaneous deletions in fictive locomotion: insights into locomotor central pattern generator organization

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Zhong, Guisheng; Shevtsova, Natalia A; Rybak, Ilya A; Harris-Warrick, Ronald M

2012-01-01

We explored the organization of the spinal central pattern generator (CPG) for locomotion by analysing the activity of spinal interneurons and motoneurons during spontaneous deletions occurring during fictive locomotion in the isolated neonatal mouse spinal cord, following earlier work on locomotor deletions in the cat. In the isolated mouse spinal cord, most spontaneous deletions were non-resetting, with rhythmic activity resuming after an integer number of cycles. Flexor and extensor deletions showed marked asymmetry: flexor deletions were accompanied by sustained ipsilateral extensor activity, whereas rhythmic flexor bursting was not perturbed during extensor deletions. Rhythmic activity on one side of the cord was not perturbed during non-resetting spontaneous deletions on the other side, and these deletions could occur with no input from the other side of the cord. These results suggest that the locomotor CPG has a two-level organization with rhythm-generating (RG) and pattern-forming (PF) networks, in which only the flexor RG network is intrinsically rhythmic. To further explore the neuronal organization of the CPG, we monitored activity of motoneurons and selected identified interneurons during spontaneous non-resetting deletions. Motoneurons lost rhythmic synaptic drive during ipsilateral deletions. Flexor-related commissural interneurons continued to fire rhythmically during non-resetting ipsilateral flexor deletions. Deletion analysis revealed two classes of rhythmic V2a interneurons. Type I V2a interneurons retained rhythmic synaptic drive and firing during ipsilateral motor deletions, while type II V2a interneurons lost rhythmic synaptic input and fell silent during deletions. This suggests that the type I neurons are components of the RG, whereas the type II neurons are components of the PF network. We propose a computational model of the spinal locomotor CPG that reproduces our experimental results. The results may provide novel insights into the

Active hippocampal networks undergo spontaneous synaptic modification.

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Masako Tsukamoto-Yasui

Full Text Available The brain is self-writable; as the brain voluntarily adapts itself to a changing environment, the neural circuitry rearranges its functional connectivity by referring to its own activity. How the internal activity modifies synaptic weights is largely unknown, however. Here we report that spontaneous activity causes complex reorganization of synaptic connectivity without any external (or artificial stimuli. Under physiologically relevant ionic conditions, CA3 pyramidal cells in hippocampal slices displayed spontaneous spikes with bistable slow oscillations of membrane potential, alternating between the so-called UP and DOWN states. The generation of slow oscillations did not require fast synaptic transmission, but their patterns were coordinated by local circuit activity. In the course of generating spontaneous activity, individual neurons acquired bidirectional long-lasting synaptic modification. The spontaneous synaptic plasticity depended on a rise in intracellular calcium concentrations of postsynaptic cells, but not on NMDA receptor activity. The direction and amount of the plasticity varied depending on slow oscillation patterns and synapse locations, and thus, they were diverse in a network. Once this global synaptic refinement occurred, the same neurons now displayed different patterns of spontaneous activity, which in turn exhibited different levels of synaptic plasticity. Thus, active networks continuously update their internal states through ongoing synaptic plasticity. With computational simulations, we suggest that with this slow oscillation-induced plasticity, a recurrent network converges on a more specific state, compared to that with spike timing-dependent plasticity alone.

Spatial diversity of spontaneous activity in the cortex

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Andrew Yong-Yi Tan

2015-09-01

Full Text Available The neocortex is a layered sheet across which a basic organization is thought to widely apply. The variety of spontaneous activity patterns is similar throughout the cortex, consistent with the notion of a basic cortical organization. However, the basic organization is only an outline which needs adjustments and additions to account for the structural and functional diversity across cortical layers and areas. Such diversity suggests that spontaneous activity is spatially diverse in any particular behavioral state. Accordingly, this review summarizes the laminar and areal diversity in cortical activity during fixation and slow oscillations, and the effects of attention, anesthesia and plasticity on the cortical distribution of spontaneous activity. Among questions that remain open, characterizing the spatial diversity in spontaneous membrane potential may help elucidate how differences in circuitry among cortical regions supports their varied functions. More work is also needed to understand whether cortical spontaneous activity not only reflects cortical circuitry, but also contributes to determining the outcome of plasticity, so that it is itself a factor shaping the functional diversity of the cortex.

Spontaneously emerging cortical representations of visual attributes

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Kenet, Tal; Bibitchkov, Dmitri; Tsodyks, Misha; Grinvald, Amiram; Arieli, Amos

2003-10-01

Spontaneous cortical activity-ongoing activity in the absence of intentional sensory input-has been studied extensively, using methods ranging from EEG (electroencephalography), through voltage sensitive dye imaging, down to recordings from single neurons. Ongoing cortical activity has been shown to play a critical role in development, and must also be essential for processing sensory perception, because it modulates stimulus-evoked activity, and is correlated with behaviour. Yet its role in the processing of external information and its relationship to internal representations of sensory attributes remains unknown. Using voltage sensitive dye imaging, we previously established a close link between ongoing activity in the visual cortex of anaesthetized cats and the spontaneous firing of a single neuron. Here we report that such activity encompasses a set of dynamically switching cortical states, many of which correspond closely to orientation maps. When such an orientation state emerged spontaneously, it spanned several hypercolumns and was often followed by a state corresponding to a proximal orientation. We suggest that dynamically switching cortical states could represent the brain's internal context, and therefore reflect or influence memory, perception and behaviour.

Associative memory model with spontaneous neural activity

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Kurikawa, Tomoki; Kaneko, Kunihiko

2012-05-01

We propose a novel associative memory model wherein the neural activity without an input (i.e., spontaneous activity) is modified by an input to generate a target response that is memorized for recall upon the same input. Suitable design of synaptic connections enables the model to memorize input/output (I/O) mappings equaling 70% of the total number of neurons, where the evoked activity distinguishes a target pattern from others. Spontaneous neural activity without an input shows chaotic dynamics but keeps some similarity with evoked activities, as reported in recent experimental studies.

Selected problems of mine ventilation under conditions of gas and fire hazards. [Poland

Energy Technology Data Exchange (ETDEWEB)

Rosiek, F; Sikora, M; Urbanski, J

1984-01-01

Activities of the the Department for Ventilation, Fires and Occupational Safety in Wroclaw are evaluated. Until 1981 the Department concentrated its research programs on ventilation in copper mines; since 1982 its programs have also covered ventilation and hazards of endogenous fire in black coal mines. The Department investigated hazards of coal spontaneous combustion in Lower Silesian coal mines and proved that the hazards are associated with occurrence of specific layers in coal seams. When coal left in the goaf area came from a layer prone to spontaneous combustion hazards of endogenous fires were high. The Department developed a method for fire prevention using periodic reversal of goaf ventilation. Schemes for reverse ventilation are discussed.

The activity of spontaneous action potentials in developing hair cells is regulated by Ca(2+-dependence of a transient K+ current.

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Snezana Levic

Full Text Available Spontaneous action potentials have been described in developing sensory systems. These rhythmic activities may have instructional roles for the functional development of synaptic connections. The importance of spontaneous action potentials in the developing auditory system is underpinned by the stark correlation between the time of auditory system functional maturity, and the cessation of spontaneous action potentials. A prominent K(+ current that regulates patterning of action potentials is I(A. This current undergoes marked changes in expression during chicken hair cell development. Although the properties of I(A are not normally classified as Ca(2+-dependent, we demonstrate that throughout the development of chicken hair cells, I(A is greatly reduced by acute alterations of intracellular Ca(2+. As determinants of spike timing and firing frequency, intracellular Ca(2+ buffers shift the activation and inactivation properties of the current to more positive potentials. Our findings provide evidence to demonstrate that the kinetics and functional expression of I(A are tightly regulated by intracellular Ca(2+. Such feedback mechanism between the functional expression of I(A and intracellular Ca(2+ may shape the activity of spontaneous action potentials, thus potentially sculpting synaptic connections in an activity-dependent manner in the developing cochlea.

New Perspectives on Spontaneous Brain Activity: Dynamic Networks and Energy Matter.

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Tozzi, Arturo; Zare, Marzieh; Benasich, April A

2016-01-01

Spontaneous brain activity has received increasing attention as demonstrated by the exponential rise in the number of published article on this topic over the last 30 years. Such "intrinsic" brain activity, generated in the absence of an explicit task, is frequently associated with resting-state or default-mode networks (DMN)s. The focus on characterizing spontaneous brain activity promises to shed new light on questions concerning the structural and functional architecture of the brain and how they are related to "mind". However, many critical questions have yet to be addressed. In this review, we focus on a scarcely explored area, specifically the energetic requirements and constraints of spontaneous activity, taking into account both thermodynamical and informational perspectives. We argue that the "classical" definitions of spontaneous activity do not take into account an important feature, that is, the critical thermodynamic energetic differences between spontaneous and evoked brain activity. Spontaneous brain activity is associated with slower oscillations compared with evoked, task-related activity, hence it exhibits lower levels of enthalpy and "free-energy" (i.e., the energy that can be converted to do work), thus supporting noteworthy thermodynamic energetic differences between spontaneous and evoked brain activity. Increased spike frequency during evoked activity has a significant metabolic cost, consequently, brain functions traditionally associated with spontaneous activity, such as mind wandering, require less energy that other nervous activities. We also review recent empirical observations in neuroscience, in order to capture how spontaneous brain dynamics and mental function can be embedded in a non-linear dynamical framework, which considers nervous activity in terms of phase spaces, particle trajectories, random walks, attractors and/or paths at the edge of the chaos. This takes us from the thermodynamic free-energy, to the realm of "variational

Learning shapes spontaneous activity itinerating over memorized states.

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Tomoki Kurikawa

Full Text Available Learning is a process that helps create neural dynamical systems so that an appropriate output pattern is generated for a given input. Often, such a memory is considered to be included in one of the attractors in neural dynamical systems, depending on the initial neural state specified by an input. Neither neural activities observed in the absence of inputs nor changes caused in the neural activity when an input is provided were studied extensively in the past. However, recent experimental studies have reported existence of structured spontaneous neural activity and its changes when an input is provided. With this background, we propose that memory recall occurs when the spontaneous neural activity changes to an appropriate output activity upon the application of an input, and this phenomenon is known as bifurcation in the dynamical systems theory. We introduce a reinforcement-learning-based layered neural network model with two synaptic time scales; in this network, I/O relations are successively memorized when the difference between the time scales is appropriate. After the learning process is complete, the neural dynamics are shaped so that it changes appropriately with each input. As the number of memorized patterns is increased, the generated spontaneous neural activity after learning shows itineration over the previously learned output patterns. This theoretical finding also shows remarkable agreement with recent experimental reports, where spontaneous neural activity in the visual cortex without stimuli itinerate over evoked patterns by previously applied signals. Our results suggest that itinerant spontaneous activity can be a natural outcome of successive learning of several patterns, and it facilitates bifurcation of the network when an input is provided.

Flow Friction or Spontaneous Ignition?

Science.gov (United States)

Stoltzfus, Joel M.; Gallus, Timothy D.; Sparks, Kyle

2012-01-01

"Flow friction," a proposed ignition mechanism in oxygen systems, has proved elusive in attempts at experimental verification. In this paper, the literature regarding flow friction is reviewed and the experimental verification attempts are briefly discussed. Another ignition mechanism, a form of spontaneous combustion, is proposed as an explanation for at least some of the fire events that have been attributed to flow friction in the literature. In addition, the results of a failure analysis performed at NASA Johnson Space Center White Sands Test Facility are presented, and the observations indicate that spontaneous combustion was the most likely cause of the fire in this 2000 psig (14 MPa) oxygen-enriched system.

Remote sensing techniques to assess active fire characteristics and post-fire effects

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Leigh B. Lentile; Zachary A. Holden; Alistair M. S. Smith; Michael J. Falkowski; Andrew T. Hudak; Penelope Morgan; Sarah A. Lewis; Paul E. Gessler; Nate C. Benson

2006-01-01

Space and airborne sensors have been used to map area burned, assess characteristics of active fires, and characterize post-fire ecological effects. Confusion about fire intensity, fire severity, burn severity, and related terms can result in the potential misuse of the inferred information by land managers and remote sensing practitioners who require unambiguous...

Synaptic model for spontaneous activity in developing networks

DEFF Research Database (Denmark)

Lerchner, Alexander; Rinzel, J.

2005-01-01

Spontaneous rhythmic activity occurs in many developing neural networks. The activity in these hyperexcitable networks is comprised of recurring "episodes" consisting of "cycles" of high activity that alternate with "silent phases" with little or no activity. We introduce a new model of synaptic...... dynamics that takes into account that only a fraction of the vesicles stored in a synaptic terminal is readily available for release. We show that our model can reproduce spontaneous rhythmic activity with the same general features as observed in experiments, including a positive correlation between...

Improving global fire carbon emissions estimates by combining moderate resolution burned area and active fire observations

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Randerson, J. T.; Chen, Y.; Giglio, L.; Rogers, B. M.; van der Werf, G.

2011-12-01

In several important biomes, including croplands and tropical forests, many small fires exist that have sizes that are well below the detection limit for the current generation of burned area products derived from moderate resolution spectroradiometers. These fires likely have important effects on greenhouse gas and aerosol emissions and regional air quality. Here we developed an approach for combining 1km thermal anomalies (active fires; MOD14A2) and 500m burned area observations (MCD64A1) to estimate the prevalence of these fires and their likely contribution to burned area and carbon emissions. We first estimated active fires within and outside of 500m burn scars in 0.5 degree grid cells during 2001-2010 for which MCD64A1 burned area observations were available. For these two sets of active fires we then examined mean fire radiative power (FRP) and changes in enhanced vegetation index (EVI) derived from 16-day intervals immediately before and after each active fire observation. To estimate the burned area associated with sub-500m fires, we first applied burned area to active fire ratios derived solely from within burned area perimeters to active fires outside of burn perimeters. In a second step, we further modified our sub-500m burned area estimates using EVI changes from active fires outside and within of burned areas (after subtracting EVI changes derived from control regions). We found that in northern and southern Africa savanna regions and in Central and South America dry forest regions, the number of active fires outside of MCD64A1 burned areas increased considerably towards the end of the fire season. EVI changes for active fires outside of burn perimeters were, on average, considerably smaller than EVI changes associated with active fires inside burn scars, providing evidence for burn scars that were substantially smaller than the 25 ha area of a single 500m pixel. FRP estimates also were lower for active fires outside of burn perimeters. In our

The influence of spontaneous activity on stimulus processing in primary visual cortex.

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Schölvinck, M L; Friston, K J; Rees, G

2012-02-01

Spontaneous activity in the resting human brain has been studied extensively; however, how such activity affects the local processing of a sensory stimulus is relatively unknown. Here, we examined the impact of spontaneous activity in primary visual cortex on neuronal and behavioural responses to a simple visual stimulus, using functional MRI. Stimulus-evoked responses remained essentially unchanged by spontaneous fluctuations, combining with them in a largely linear fashion (i.e., with little evidence for an interaction). However, interactions between spontaneous fluctuations and stimulus-evoked responses were evident behaviourally; high levels of spontaneous activity tended to be associated with increased stimulus detection at perceptual threshold. Our results extend those found in studies of spontaneous fluctuations in motor cortex and higher order visual areas, and suggest a fundamental role for spontaneous activity in stimulus processing. Copyright © 2011. Published by Elsevier Inc.

Spontaneous neutrophil activation in HTLV-1 infected patients

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Jaqueline B. Guerreiro

Full Text Available Human T cell lymphotropic Virus type-1 (HTLV-1 induces lymphocyte activation and proliferation, but little is known about the innate immune response due to HTLV-1 infection. We evaluated the percentage of neutrophils that metabolize Nitroblue tetrazolium (NBT to formazan in HTLV-1 infected subjects and the association between neutrophil activation and IFN-gamma and TNF-alpha levels. Blood was collected from 35 HTLV-1 carriers, from 8 patients with HAM/TSP (HTLV-1- associated myelopathy; 22 healthy individuals were evaluated for spontaneous and lipopolysaccharide (LPS-stimulated neutrophil activity (reduction of NBT to formazan. The production of IFN-gamma and TNF-alpha by unstimulated mononuclear cells was determined by ELISA. Spontaneous NBT levels, as well as spontaneous IFN-gamma and TNF-alpha production, were significantly higher (p<0.001 in HTLV-1 infected subjects than in healthy individuals. A trend towards a positive correlation was noted, with increasing percentage of NBT positive neutrophils and levels of IFN-gamma. The high IFN-gamma producing HTLV-1 patient group had significantly greater NBT than healthy controls, 43±24% and 17±4.8% respectively (p< 0.001, while no significant difference was observed between healthy controls and the low IFN-gamma-producing HTLV-1 patient group (30±20%. Spontaneous neutrophil activation is another marker of immune perturbation resulting from HTLV-1 infection. In vivo activation of neutrophils observed in HTLV-1 infected subjects is likely to be the same process that causes spontaneous IFN-gamma production, or it may partially result from direct IFN-gamma stimulation.

Management of synchronized network activity by highly active neurons

International Nuclear Information System (INIS)

Shein, Mark; Raichman, Nadav; Ben-Jacob, Eshel; Volman, Vladislav; Hanein, Yael

2008-01-01

Increasing evidence supports the idea that spontaneous brain activity may have an important functional role. Cultured neuronal networks provide a suitable model system to search for the mechanisms by which neuronal spontaneous activity is maintained and regulated. This activity is marked by synchronized bursting events (SBEs)—short time windows (hundreds of milliseconds) of rapid neuronal firing separated by long quiescent periods (seconds). However, there exists a special subset of rapidly firing neurons whose activity also persists between SBEs. It has been proposed that these highly active (HA) neurons play an important role in the management (i.e. establishment, maintenance and regulation) of the synchronized network activity. Here, we studied the dynamical properties and the functional role of HA neurons in homogeneous and engineered networks, during early network development, upon recovery from chemical inhibition and in response to electrical stimulations. We found that their sequences of inter-spike intervals (ISI) exhibit long time correlations and a unimodal distribution. During the network's development and under intense inhibition, the observed activity follows a transition period during which mostly HA neurons are active. Studying networks with engineered geometry, we found that HA neurons are precursors (the first to fire) of the spontaneous SBEs and are more responsive to electrical stimulations

Fire, Climate, and Human Activity: A Combustive Combination

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Kehrwald, N. M.; Battistel, D.; Argiriadis, E.; Barbante, C.; Barber, L. B.; Fortner, S. K.; Jasmann, J.; Kirchgeorg, T.; Zennaro, P.

2017-12-01

Ice and lake core records demonstrate that fires caused by human activity can dominate regional biomass burning records in the Common Era. These major increases in fires are often associated with extensive land use change such as an expansion in agriculture. Regions with few humans, relatively stable human populations and/or unvarying land use often have fire histories that are dominated by climate parameters such as temperature and precipitation. Here, we examine biomass burning recorded in ice cores from northern Greenland (NEEM, (77°27'N; 51°3.6'W), Alaska (Juneau Icefield, 58° 35' N; 134° 29'W) and East Antarctica (EPICA DOME C; 75°06'S; 123°21'E), along with New Zealand lake cores to investigate interactions between climate, fire and human activity. Biomarkers such as levoglucosan, and its isomers mannosan and galactosan, can only be produced by cellulose combustion and therefore are specific indicators of past fire activity archived in ice and lake cores. These fire histories add another factor to climate proxies from the same core, and provide a comparison to regional fire syntheses from charcoal records and climate models. For example, fire data from the JSBACH-Spitfire model for the past 2000 years demonstrates that a climate-only scenario would not increase biomass burning in high northern latitudes for the past 2000 years, while NEEM ice core and regional pollen records demonstrate both increased fire activity and land use change that may be ascribed to human activity. Additional biomarkers such as fecal sterols in lake sediments can determine when people were in an area, and can help establish if an increased human presence in an area corresponds with intensified fire activity. This combination of specific biomarkers, other proxy data, and model output can help determine the relative impact of humans versus climate factors on regional fire activity.

Bistable firing properties of soleus motor units in unrestrained rats

DEFF Research Database (Denmark)

EKEN, T.; KIEHN, O.

1989-01-01

of the motoneuron pool by stimulation of la afferents, or inhibition by stimulation of skin afferents. The shifts were not related to gross limb movements. This phenomenon is referred to as a bistable firing pattern. Bistable firing also occurred spontaneously during quiet standing. Typically the firing frequency...... was unchanged or only phasically influenced. These results demonstrate for the first time a bistable firing pattern during postural activity in the intact animal. The firing pattern closely resembles the bistable behaviour described in spinal motoneurons in reduced preparations, where it is due to the presence...... of a plateau potential. This suggests that the bistable firing is unexplained by plateau potentials also in the intact animal....

Primer on spontaneous heating and pyrophoricity

Energy Technology Data Exchange (ETDEWEB)

1994-12-01

This primer was prepared as an information resource for personnel responsible for operation of DOE nuclear facilities. It has sections on combustion principles, spontaneous heating/ignition of hydrocarbons and organics, pyrophoric gases and liquids, pyrophoric nonmetallic solids, pyrophoric metals (including Pu and U), and accident case studies. Although the information in this primer is not all-encompassing, it should provide the reader with a fundamental knowledge level sufficient to recognize most spontaneous combustion hazards and how to prevent ignition and widespread fires. This primer is provided as an information resource only, and is not intended to replace any fire protection or hazardous material training.

Quantifying emissions from spontaneous combustion

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-09-01

Spontaneous combustion can be a significant problem in the coal industry, not only due to the obvious safety hazard and the potential loss of valuable assets, but also with respect to the release of gaseous pollutants, especially CO2, from uncontrolled coal fires. This report reviews methodologies for measuring emissions from spontaneous combustion and discusses methods for quantifying, estimating and accounting for the purpose of preparing emission inventories.

Pipeline oil fire detection with MODIS active fire products

Science.gov (United States)

Ogungbuyi, M. G.; Martinez, P.; Eckardt, F. D.

2017-12-01

We investigate 85 129 MODIS satellite active fire events from 2007 to 2015 in the Niger Delta of Nigeria. The region is the oil base for Nigerian economy and the hub of oil exploration where oil facilities (i.e. flowlines, flow stations, trunklines, oil wells and oil fields) are domiciled, and from where crude oil and refined products are transported to different Nigerian locations through a network of pipeline systems. Pipeline and other oil facilities are consistently susceptible to oil leaks due to operational or maintenance error, and by acts of deliberate sabotage of the pipeline equipment which often result in explosions and fire outbreaks. We used ground oil spill reports obtained from the National Oil Spill Detection and Response Agency (NOSDRA) database (see www.oilspillmonitor.ng) to validate MODIS satellite data. NOSDRA database shows an estimate of 10 000 spill events from 2007 - 2015. The spill events were filtered to include largest spills by volume and events occurring only in the Niger Delta (i.e. 386 spills). By projecting both MODIS fire and spill as `input vector' layers with `Points' geometry, and the Nigerian pipeline networks as `from vector' layers with `LineString' geometry in a geographical information system, we extracted the nearest MODIS events (i.e. 2192) closed to the pipelines by 1000m distance in spatial vector analysis. The extraction process that defined the nearest distance to the pipelines is based on the global practices of the Right of Way (ROW) in pipeline management that earmarked 30m strip of land to the pipeline. The KML files of the extracted fires in a Google map validated their source origin to be from oil facilities. Land cover mapping confirmed fire anomalies. The aim of the study is to propose a near-real-time monitoring of spill events along pipeline routes using 250 m spatial resolution of MODIS active fire detection sensor when such spills are accompanied by fire events in the study location.

Default activity patterns at the neocortical microcircuit level

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Artur eLuczak

2012-06-01

Full Text Available Even in absence of sensory stimuli cortical networks exhibit complex, self-organized activity patterns. While the function of those spontaneous patterns of activation remains poorly understood, recent studies both in vivo and in vitro have demonstrated that neocortical neurons activate in a surprisingly similar sequential order both spontaneously and following input into cortex. For example, neurons that tend to fire earlier within spontaneous bursts of activity also fire earlier than other neurons in response to sensory stimuli. These 'default patterns' can last hundreds of milliseconds and are strongly conserved under a variety of conditions. In this paper we will review recent evidence for these default patterns at the local cortical level. We speculate that cortical architecture imposes common constraints on spontaneous and evoked activity flow, which result in the similarity of the patterns.

Mechanisms of morphine enhancement of spontaneous seizure activity.

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Saboory, Ehsan; Derchansky, Miron; Ismaili, Mohammed; Jahromi, Shokrollah S; Brull, Richard; Carlen, Peter L; El Beheiry, Hossam

2007-12-01

High-dose opioid therapy can precipitate seizures; however, the mechanism of such a dangerous adverse effect remains poorly understood. The aim of our study was to determine whether the neuroexcitatory activity of high-dose morphine is mediated by selective stimulation of opioid receptors. Mice hippocampi were resected intact and bathed in low magnesium artificial cerebrospinal fluid to induce spontaneous seizure-like events recorded from CA1 neurons. Application of morphine had a biphasic effect on the recorded spontaneous seizure-like events. In a low concentration (10 microM), morphine depressed electrographic seizure activity. Higher morphine concentrations (30 and 100 microM) enhanced seizure activity in an apparent dose-dependent manner. Naloxone, a nonselective opiate antagonist blocked the proconvulsant action of morphine. Selective mu and kappa opiate receptor agonists and antagonists enhanced and suppressed the spontaneous seizure activity, respectively. On the contrary, delta opioid receptor ligands did not have an effect. The proseizure effect of morphine is mediated through selective stimulation of mu and kappa opiate receptors but not the activation of the delta receptor system. The observed dose-dependent mechanism of morphine neuroexcitation underscores careful adjustment and individualized opioid dosing in the clinical setting.

Synaptic and intrinsic activation of GABAergic neurons in the cardiorespiratory brainstem network.

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Frank, Julie G; Mendelowitz, David

2012-01-01

GABAergic pathways in the brainstem play an essential role in respiratory rhythmogenesis and interactions between the respiratory and cardiovascular neuronal control networks. However, little is known about the identity and function of these GABAergic inhibitory neurons and what determines their activity. In this study we have identified a population of GABAergic neurons in the ventrolateral medulla that receive increased excitatory post-synaptic potentials during inspiration, but also have spontaneous firing in the absence of synaptic input. Using transgenic mice that express GFP under the control of the Gad1 (GAD67) gene promoter, we determined that this population of GABAergic neurons is in close apposition to cardioinhibitory parasympathetic cardiac neurons in the nucleus ambiguus (NA). These neurons fire in synchronization with inspiratory activity. Although they receive excitatory glutamatergic synaptic inputs during inspiration, this excitatory neurotransmission was not altered by blocking nicotinic receptors, and many of these GABAergic neurons continue to fire after synaptic blockade. The spontaneous firing in these GABAergic neurons was not altered by the voltage-gated calcium channel blocker cadmium chloride that blocks both neurotransmission to these neurons and voltage-gated Ca(2+) currents, but spontaneous firing was diminished by riluzole, demonstrating a role of persistent sodium channels in the spontaneous firing in these cardiorespiratory GABAergic neurons that possess a pacemaker phenotype. The spontaneously firing GABAergic neurons identified in this study that increase their activity during inspiration would support respiratory rhythm generation if they acted primarily to inhibit post-inspiratory neurons and thereby release inspiration neurons to increase their activity. This population of inspiratory-modulated GABAergic neurons could also play a role in inhibiting neurons that are most active during expiration and provide a framework for

Synaptic and intrinsic activation of GABAergic neurons in the cardiorespiratory brainstem network.

Directory of Open Access Journals (Sweden)

Julie G Frank

Full Text Available GABAergic pathways in the brainstem play an essential role in respiratory rhythmogenesis and interactions between the respiratory and cardiovascular neuronal control networks. However, little is known about the identity and function of these GABAergic inhibitory neurons and what determines their activity. In this study we have identified a population of GABAergic neurons in the ventrolateral medulla that receive increased excitatory post-synaptic potentials during inspiration, but also have spontaneous firing in the absence of synaptic input. Using transgenic mice that express GFP under the control of the Gad1 (GAD67 gene promoter, we determined that this population of GABAergic neurons is in close apposition to cardioinhibitory parasympathetic cardiac neurons in the nucleus ambiguus (NA. These neurons fire in synchronization with inspiratory activity. Although they receive excitatory glutamatergic synaptic inputs during inspiration, this excitatory neurotransmission was not altered by blocking nicotinic receptors, and many of these GABAergic neurons continue to fire after synaptic blockade. The spontaneous firing in these GABAergic neurons was not altered by the voltage-gated calcium channel blocker cadmium chloride that blocks both neurotransmission to these neurons and voltage-gated Ca(2+ currents, but spontaneous firing was diminished by riluzole, demonstrating a role of persistent sodium channels in the spontaneous firing in these cardiorespiratory GABAergic neurons that possess a pacemaker phenotype. The spontaneously firing GABAergic neurons identified in this study that increase their activity during inspiration would support respiratory rhythm generation if they acted primarily to inhibit post-inspiratory neurons and thereby release inspiration neurons to increase their activity. This population of inspiratory-modulated GABAergic neurons could also play a role in inhibiting neurons that are most active during expiration and provide a

Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells.

Science.gov (United States)

Johnson, Stuart L; Eckrich, Tobias; Kuhn, Stephanie; Zampini, Valeria; Franz, Christoph; Ranatunga, Kishani M; Roberts, Terri P; Masetto, Sergio; Knipper, Marlies; Kros, Corné J; Marcotti, Walter

2011-06-01

Spontaneous action potential activity is crucial for mammalian sensory system development. In the auditory system, patterned firing activity has been observed in immature spiral ganglion and brain-stem neurons and is likely to depend on cochlear inner hair cell (IHC) action potentials. It remains uncertain whether spiking activity is intrinsic to developing IHCs and whether it shows patterning. We found that action potentials were intrinsically generated by immature IHCs of altricial rodents and that apical IHCs showed bursting activity as opposed to more sustained firing in basal cells. We show that the efferent neurotransmitter acetylcholine fine-tunes the IHC's resting membrane potential (V(m)), and as such is crucial for the bursting pattern in apical cells. Endogenous extracellular ATP also contributes to the V(m) of apical and basal IHCs by triggering small-conductance Ca(2+)-activated K(+) (SK2) channels. We propose that the difference in firing pattern along the cochlea instructs the tonotopic differentiation of IHCs and auditory pathway.

Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells

Science.gov (United States)

Johnson, Stuart L.; Eckrich, Tobias; Kuhn, Stephanie; Zampini, Valeria; Franz, Christoph; Ranatunga, Kishani M.; Roberts, Terri P.; Masetto, Sergio; Knipper, Marlies; Kros, Corné J.; Marcotti, Walter

2011-01-01

Spontaneous action potential activity is crucial for mammalian sensory system development. In the auditory system, patterned firing activity has been observed in immature spiral ganglion cells and brain-stem neurons and is likely to depend on cochlear inner hair cell (IHC) action potentials. It remains uncertain whether spiking activity is intrinsic to developing IHCs and whether it shows patterning. We found that action potentials are intrinsically generated by immature IHCs of altricial rodents and that apical IHCs exhibit bursting activity as opposed to more sustained firing in basal cells. We show that the efferent neurotransmitter ACh, by fine-tuning the IHC’s resting membrane potential (Vm), is crucial for the bursting pattern in apical cells. Endogenous extracellular ATP also contributes to the Vm of apical and basal IHCs by activating SK2 channels. We hypothesize that the difference in firing pattern along the cochlea instructs the tonotopic differentiation of IHCs and auditory pathway. PMID:21572434

Which nerve conduction parameters can predict spontaneous electromyographic activity in carpal tunnel syndrome?

Science.gov (United States)

Chang, Chia-Wei; Lee, Wei-Ju; Liao, Yi-Chu; Chang, Ming-Hong

2013-11-01

We investigate electrodiagnostic markers to determine which parameters are the best predictors of spontaneous electromyographic (EMG) activity in carpal tunnel syndrome (CTS). We enrolled 229 patients with clinically proven and nerve conduction study (NCS)-proven CTS, as well as 100 normal control subjects. All subjects were evaluated using electrodiagnostic techniques, including median distal sensory latencies (DSLs), sensory nerve action potentials (SNAPs), distal motor latencies (DMLs), compound muscle action potentials (CMAPs), forearm median nerve conduction velocities (FMCVs) and wrist-palm motor conduction velocities (W-P MCVs). All CTS patients underwent EMG examination of the abductor pollicis brevis (APB) muscle, and the presence or absence of spontaneous EMG activities was recorded. Normal limits were determined by calculating the means ± 2 standard deviations from the control data. Associations between parameters from the NCS and EMG findings were investigated. In patients with clinically diagnosed CTS, abnormal median CMAP amplitudes were the best predictors of spontaneous activity during EMG examination (p95% (positive predictive rate >95%). If the median CMAP amplitude was higher than the normal limit (>4.9 mV), the rate of no spontaneous EMG activity was >94% (negative predictive rate >94%). An abnormal SNAP amplitude was the second best predictor of spontaneous EMG activity (p<0.001; OR 4.13; 95% CI 2.16-7.90), and an abnormal FMCV was the third best predictor (p=0.01; OR 2.10; 95% CI 1.20-3.67). No other nerve conduction parameters had significant power to predict spontaneous activity upon EMG examination. The CMAP amplitudes of the APB are the most powerful predictors of the occurrence of spontaneous EMG activity. Low CMAP amplitudes are strongly associated with spontaneous activity, whereas high CMAP amplitude are less associated with spontaneous activity, implying that needle EMG examination should be recommended for the detection of

Spontaneous emission from active dielectric microstructures

DEFF Research Database (Denmark)

Søndergaard, Thomas; Tromborg, Bjarne

2001-01-01

and engineered due to the dependence of the emission rate on the location and polarisation of the emitters in the structure. This paper addresses the methods of quantum electrodynamics of dielectric media which enable calculation of the local rate of spontaneous emission in active microstructures....

Inhibition Effect of Phosphorus Flame Retardants on the Fire Disasters Induced by Spontaneous Combustion of Coal

Directory of Open Access Journals (Sweden)

Yibo Tang

2017-01-01

Full Text Available Coal spontaneous combustion (CSC generally induces fire disasters in underground mines, thus causing serious casualties, environmental pollution, and property loss around the world. By using six P-containing additives to process three typical coal samples, this study investigated the variations of the self-ignition characteristics of the coal samples before and after treatment. The analysis was performed by combining thermogravimetric analysis/differential scanning calorimetry (TG/DSC Fourier transform infrared spectrometer (FTIR and low temperature oxidation. Experimental results showed that P-containing inhibitors could effectively restrain the heat emitted in the combustion of coal samples and therefore the ignition temperature of the coal samples was delayed at varying degrees. The combustion rate of the coal samples was reduced as well. At the temperatures ranging from 50°C to 150°C, the activation energy of the coal samples after the treatment was found to increase, which indicated that the coal samples were more difficult to be oxidized. After being treated with phosphorus flame retardants (PFRs, the content of several active groups represented by the C-O structure in the three coal samples was proved to be obviously changed. This suggested that PFRs could significantly inhibit the content of CO generated by the low temperature oxidation of coal, and the flame-retardant efficiency grew with the increasing temperature. At 200°C, the maximal inhibition efficiency reached approximately 85%.

Aging assessment for active fire protection systems

International Nuclear Information System (INIS)

Ross, S.B.; Nowlen, S.P.; Tanaka, T.

1995-06-01

This study assessed the impact of aging on the performance and reliability of active fire protection systems including both fixed fire suppression and fixed fire detection systems. The experience base shows that most nuclear power plants have an aggressive maintenance and testing program and are finding degraded fire protection system components before a failure occurs. Also, from the data reviewed it is clear that the risk impact of fire protection system aging is low. However, it is assumed that a more aggressive maintenance and testing program involving preventive diagnostics may reduce the risk impact even further

The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression.

Science.gov (United States)

Donato, Roberta; Page, Karen M; Koch, Dietlind; Nieto-Rostro, Manuela; Foucault, Isabelle; Davies, Anthony; Wilkinson, Tonia; Rees, Michele; Edwards, Frances A; Dolphin, Annette C

2006-11-29

The mouse mutant ducky and its allele ducky(2J) represent a model for absence epilepsy characterized by spike-wave seizures and cerebellar ataxia. These mice have mutations in Cacna2d2, which encodes the alpha2delta-2 calcium channel subunit. Of relevance to the ataxic phenotype, alpha2delta-2 mRNA is strongly expressed in cerebellar Purkinje cells (PCs). The Cacna2d2(du2J) mutation results in a 2 bp deletion in the coding region and a complete loss of alpha2delta-2 protein. Here we show that du(2J)/du(2J) mice have a 30% reduction in somatic calcium current and a marked fall in the spontaneous PC firing rate at 22 degrees C, accompanied by a decrease in firing regularity, which is not affected by blocking synaptic input to PCs. At 34 degrees C, du(2J)/du(2J) PCs show no spontaneous intrinsic activity. Du(2J)/du(2J) mice also have alterations in the cerebellar expression of several genes related to PC function. At postnatal day 21, there is an elevation of tyrosine hydroxylase mRNA and a reduction in tenascin-C gene expression. Although du(2J)/+ mice have a marked reduction in alpha2delta-2 protein, they show no fall in PC somatic calcium currents or increase in cerebellar tyrosine hydroxylase gene expression. However, du(2J)/+ PCs do exhibit a significant reduction in firing rate, correlating with the reduction in alpha2delta-2. A hypothesis for future study is that effects on gene expression occur as a result of a reduction in somatic calcium currents, whereas effects on PC firing occur as a long-term result of loss of alpha2delta-2 and/or a reduction in calcium currents and calcium-dependent processes in regions other than the soma.

The Cooney Ridge Fire Experiment: An early operation to relate pre-, active, and post-fire field and remotely sensed measurements

Science.gov (United States)

Andrew T. Hudak; Patrick H. Freeborn; Sarah A. Lewis; Sharon M. Hood; Helen Y. Smith; Colin C. Hardy; Robert J. Kremens; Bret W. Butler; Casey Teske; Robert G. Tissell; Lloyd P. Queen; Bryce L. Nordgren; Benjamin C. Bright; Penelope Morgan; Philip J. Riggan; Lee Macholz; Leigh B. Lentile; James P. Riddering; Edward E. Mathews

2018-01-01

The Cooney Ridge Fire Experiment conducted by fire scientists in 2003 was a burnout operation supported by a fire suppression crew on the active Cooney Ridge wildfire incident. The fire experiment included measurements of pre-fire fuels, active fire behavior, and immediate post-fire effects. Heat flux measurements collected at multiple scales with multiple ground and...

Spontaneous Gamma Activity in Schizophrenia.

Science.gov (United States)

Hirano, Yoji; Oribe, Naoya; Kanba, Shigenobu; Onitsuka, Toshiaki; Nestor, Paul G; Spencer, Kevin M

2015-08-01

A major goal of translational neuroscience is to identify neural circuit abnormalities in neuropsychiatric disorders that can be studied in animal models to facilitate the development of new treatments. Oscillations in the gamma band (30-100 Hz) of the electroencephalogram have received considerable interest as the basic mechanisms underlying these oscillations are understood, and gamma abnormalities have been found in schizophrenia (SZ). Animal models of SZ based on hypofunction of the N-methyl-d-aspartate receptor (NMDAR) demonstrate increased spontaneous broadband gamma power, but this phenomenon has not been identified clearly in patients with SZ. To examine spontaneous gamma power and its relationship to evoked gamma oscillations in the auditory cortex of patients with SZ. We performed a cross-sectional study including 24 patients with chronic SZ and 24 matched healthy control participants at the Veterans Affairs Boston Healthcare System from January 1, 2009, through December 31, 2012. Electroencephalograms were obtained during auditory steady-state stimulation at multiple frequencies (20, 30, and 40 Hz) and during a resting state in 18 participants in each group. Electroencephalographic activity in the auditory cortex was estimated using dipole source localization. Auditory steady-state response (ASSR) measures included the phase-locking factor and evoked power. Spontaneous gamma power was measured as induced (non-phase-locked) gamma power in the ASSR data and as total gamma power in the resting-state data. The ASSR phase-locking factor was reduced significantly in patients with SZ compared with controls for the 40-Hz stimulation (mean [SD], 0.075 [0.028] vs 0.113 [0.065]; F1,46 = 6.79 [P = .012]) but not the 20- or the 30-Hz stimulation (0.042 [0.038] vs 0.043 [0.034]; F1,46 = 0.006 [P = .938] and 0.084 [0.040] vs 0.098 [0.050]; F1,46 = 1.605 [P = .212], respectively), repeating previous findings. The mean [SD] broadband-induced (30

Experimental investigation on spontaneously active hippocampal cultures recorded by means of high-density MEAs: analysis of the spatial resolution effects

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Alessandro Maccione

2010-05-01

Full Text Available Based on experiments performed with high-resolution Active Pixel Sensor microelectrode arrays (APS-MEAs coupled with spontaneously active hippocampal cultures, this work investigates the spatial resolution effects of the neuroelectronic interface on the analysis of the recorded electrophysiological signals. The adopted methodology consists, first, in recording the spontaneous activity at the highest spatial resolution (inter-electrode separation of 21 µm from the whole array of 4096 microelectrodes. Then, the full resolution dataset is spatially down sampled in order to evaluate the effects on raster plot representation, array-wide spike rate (AWSR, mean firing rate (MFR and mean bursting rate (MBR. Furthermore, the effects of the array-to-network relative position are evaluated by shifting a subset of equally spaced electrodes on the entire recorded area. Results highlight that MFR and MBR are particularly influenced by the spatial resolution provided by the neuroelectronic interface. On high-resolution large MEAs, such analysis better represent the time-based parameterization of the network dynamics. Finally, this work suggest interesting capabilities of high-resolution MEAs for spatial-based analysis in dense and low-dense neuronal preparation for investigating signalling at both local and global neuronal circuitries.

Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: Relevance for schizophrenia.

Science.gov (United States)

Tufvesson-Alm, Maximilian; Schwieler, Lilly; Schwarcz, Robert; Goiny, Michel; Erhardt, Sophie; Engberg, Göran

2018-06-05

Kynurenine 3-monooxygenase (KMO) is an essential enzyme of the kynurenine pathway, converting kynurenine into 3-hydroxykynurenine. Inhibition of KMO increases kynurenine, resulting in elevated levels of kynurenic acid (KYNA), an endogenous N-methyl-d-aspartate and α*7-nicotinic receptor antagonist. The concentration of KYNA is elevated in the brain of patients with schizophrenia, possibly as a result of a reduced KMO activity. In the present study, using in vivo single cell recording techniques, we investigated the electrophysiological characteristics of ventral tegmental area dopamine (VTA DA) neurons and their response to antipsychotic drugs in a KMO knock-out (K/O) mouse model. KMO K/O mice exhibited a marked increase in spontaneous VTA DA neuron activity as compared to wild-type (WT) mice. Furthermore, VTA DA neurons showed clear-cut, yet qualitatively opposite, responses to the antipsychotic drugs haloperidol and clozapine in the two genotypes. The anti-inflammatory drug parecoxib successfully lowered the firing activity of VTA DA neurons in KMO K/O, but not in WT mice. Minocycline, an antibiotic and anti-inflammatory drug, produced no effect in this regard. Taken together, the present data further support the usefulness of KMO K/O mice for studying distinct aspects of the pathophysiology and pharmacological treatment of psychiatric disorders such as schizophrenia. Copyright © 2018. Published by Elsevier Ltd.

Mapping the Daily Progression of Large Wildland Fires Using MODIS Active Fire Data

Science.gov (United States)

Veraverbeke, Sander; Sedano, Fernando; Hook, Simon J.; Randerson, James T.; Jin, Yufang; Rogers, Brendan

2013-01-01

High temporal resolution information on burned area is a prerequisite for incorporating bottom-up estimates of wildland fire emissions in regional air transport models and for improving models of fire behavior. We used the Moderate Resolution Imaging Spectroradiometer (MODIS) active fire product (MO(Y)D14) as input to a kriging interpolation to derive continuous maps of the evolution of nine large wildland fires. For each fire, local input parameters for the kriging model were defined using variogram analysis. The accuracy of the kriging model was assessed using high resolution daily fire perimeter data available from the U.S. Forest Service. We also assessed the temporal reporting accuracy of the MODIS burned area products (MCD45A1 and MCD64A1). Averaged over the nine fires, the kriging method correctly mapped 73% of the pixels within the accuracy of a single day, compared to 33% for MCD45A1 and 53% for MCD64A1.

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain.

Directory of Open Access Journals (Sweden)

David J Matson

Full Text Available While genetic evidence shows that the Nav1.7 voltage-gated sodium ion channel is a key regulator of pain, it is unclear exactly how Nav1.7 governs neuronal firing and what biophysical, physiological, and distribution properties of a pharmacological Nav1.7 inhibitor are required to produce analgesia. Here we characterize a series of aminotriazine inhibitors of Nav1.7 in vitro and in rodent models of pain and test the effects of the previously reported "compound 52" aminotriazine inhibitor on the spiking properties of nociceptors in vivo. Multiple aminotriazines, including some with low terminal brain to plasma concentration ratios, showed analgesic efficacy in the formalin model of pain. Effective concentrations were consistent with the in vitro potency as measured on partially-inactivated Nav1.7 but were far below concentrations required to inhibit non-inactivated Nav1.7. Compound 52 also reversed thermal hyperalgesia in the complete Freund's adjuvant (CFA model of pain. To study neuronal mechanisms, electrophysiological recordings were made in vivo from single nociceptive fibers from the rat tibial nerve one day after CFA injection. Compound 52 reduced the spontaneous firing of C-fiber nociceptors from approximately 0.7 Hz to 0.2 Hz and decreased the number of action potentials evoked by suprathreshold tactile and heat stimuli. It did not, however, appreciably alter the C-fiber thresholds for response to tactile or thermal stimuli. Surprisingly, compound 52 did not affect spontaneous activity or evoked responses of Aδ-fiber nociceptors. Results suggest that inhibition of inactivated states of TTX-S channels, mostly likely Nav1.7, in the peripheral nervous system produces analgesia by regulating the spontaneous discharge of C-fiber nociceptors.

Tamsulosin modulates, but does not abolish the spontaneous activity in the guinea pig prostate gland.

Science.gov (United States)

Chakrabarty, Basu; Dey, Anupa; Lam, Michelle; Ventura, Sabatino; Exintaris, Betty

2015-06-01

To examine the effects of the α1A -adrenoceptor antagonist, tamsulosin, on spontaneous contractile and electrical activity in the guinea-pig prostate gland. The effects of tamsulosin (0.1 and 0.3 nM) were investigated in adult and ageing male guinea pig prostate glands using conventional tension recording and electrophysiological intracellular microelectrode recording techniques. Tamsulosin reduced spontaneous activity, and had different age-dependent effects on adult and ageing guinea pigs at different concentrations. 0.1 nM tamsulosin caused a significantly greater reduction of spontaneous contractile and electrical activity in ageing guinea pigs in comparison to adult guinea pigs. In contrast, 0.3 nM tamsulosin had a significantly greater reduction of spontaneous contractile and electrical activity in adult guinea pigs in comparison to ageing guinea pigs. This study demonstrates that tamsulosin can modulate spontaneous myogenic stromal contractility and the underlying spontaneous electrical activity; tamsulosin does not block spontaneous activity. This reduction in spontaneous activity suggests that downstream cellular mechanisms underlying smooth muscle tone are being targeted, and these may represent novel therapeutic targets to better treat benign prostatic hyperplasia. © 2014 Wiley Periodicals, Inc.

Noise-induced effects on multicellular biopacemaker spontaneous activity: Differences between weak and strong pacemaker cells

Science.gov (United States)

Aghighi, Alireza; Comtois, Philippe

2017-09-01

Self-organization of spontaneous activity of a network of active elements is important to the general theory of reaction-diffusion systems as well as for pacemaking activity to initiate beating of the heart. Monolayer cultures of neonatal rat ventricular myocytes, consisting of resting and pacemaker cells, exhibit spontaneous activation of their electrical activity. Similarly, one proposed approach to the development of biopacemakers as an alternative to electronic pacemakers for cardiac therapy is based on heterogeneous cardiac cells with resting and spontaneously beating phenotypes. However, the combined effect of pacemaker characteristics, density, and spatial distribution of the pacemaker cells on spontaneous activity is unknown. Using a simple stochastic pattern formation algorithm, we previously showed a clear nonlinear dependency of spontaneous activity (occurrence and amplitude of spontaneous period) on the spatial patterns of pacemaker cells. In this study, we show that this behavior is dependent on the pacemaker cell characteristics, with weaker pacemaker cells requiring higher density and larger clusters to sustain multicellular activity. These multicellular structures also demonstrated an increased sensitivity to voltage noise that favored spontaneous activity at lower density while increasing temporal variation in the period of activity. This information will help researchers overcome the current limitations of biopacemakers.

Fear Expression Suppresses Medial Prefrontal Cortical Firing in Rats.

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Thomas F Giustino

Full Text Available The medial prefrontal cortex (mPFC plays a crucial role in emotional learning and memory in rodents and humans. While many studies suggest a differential role for the prelimbic (PL and infralimbic (IL subdivisions of mPFC, few have considered the relationship between neural activity in these two brain regions recorded simultaneously in behaving animals. Importantly, how concurrent PL and IL activity relate to conditioned freezing behavior is largely unknown. Here we used single-unit recordings targeting PL and IL in awake, behaving rats during the acquisition and expression of conditioned fear. On Day 1, rats received either signaled or unsignaled footshocks in the recording chamber; an auditory conditioned stimulus (CS preceded signaled footshocks. Twenty-four hours later, animals were returned to the recording chamber (modified to create a novel context where they received 5 CS-alone trials. After fear conditioning, both signaled and unsignaled rats exhibited high levels of post-shock freezing that was associated with an enduring suppression of mPFC spontaneous firing, particularly in the IL of signaled rats. Twenty-four hours later, CS presentation produced differential conditioned freezing in signaled and unsignaled rats: freezing increased in rats that had received signaled shocks, but decreased in animals in the unsignaled condition (i.e., external inhibition. This group difference in CS-evoked freezing was mirrored in the spontaneous firing rate of neurons in both PL and IL. Interestingly, differences in PL and IL firing rate highly correlated with freezing levels. In other words, in the signaled group IL spontaneous rates were suppressed relative to PL, perhaps limiting IL-mediated suppression of fear and allowing PL activity to dominate performance, resulting in high levels of freezing. This was not observed in the unsignaled group, which exhibited low freezing. These data reveal that the activity of mPFC neurons is modulated by both

Ongoing spontaneous activity controls access to consciousness: a neuronal model for inattentional blindness.

Directory of Open Access Journals (Sweden)

Stanislas Dehaene

2005-05-01

Full Text Available Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood. We use computer simulations to explore the conditions under which spontaneous activity emerges from a simplified model of multiple interconnected thalamocortical columns linked by long-range, top-down excitatory axons, and to examine its interactions with stimulus-induced activation. Simulations help characterize two main states of activity. First, spontaneous gamma-band oscillations emerge at a precise threshold controlled by ascending neuromodulator systems. Second, within a spontaneously active network, we observe the sudden "ignition" of one out of many possible coherent states of high-level activity amidst cortical neurons with long-distance projections. During such an ignited state, spontaneous activity can block external sensory processing. We relate those properties to experimental observations on the neural bases of endogenous states of consciousness, and particularly the blocking of access to consciousness that occurs in the psychophysical phenomenon of "inattentional blindness," in which normal subjects intensely engaged in mental activity fail to notice salient but irrelevant sensory stimuli. Although highly simplified, the generic properties of a minimal network may help clarify some of the basic cerebral phenomena underlying the autonomy of consciousness.

Ongoing spontaneous activity controls access to consciousness: a neuronal model for inattentional blindness.

Science.gov (United States)

Dehaene, Stanislas; Changeux, Jean-Pierre

2005-05-01

Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood. We use computer simulations to explore the conditions under which spontaneous activity emerges from a simplified model of multiple interconnected thalamocortical columns linked by long-range, top-down excitatory axons, and to examine its interactions with stimulus-induced activation. Simulations help characterize two main states of activity. First, spontaneous gamma-band oscillations emerge at a precise threshold controlled by ascending neuromodulator systems. Second, within a spontaneously active network, we observe the sudden "ignition" of one out of many possible coherent states of high-level activity amidst cortical neurons with long-distance projections. During such an ignited state, spontaneous activity can block external sensory processing. We relate those properties to experimental observations on the neural bases of endogenous states of consciousness, and particularly the blocking of access to consciousness that occurs in the psychophysical phenomenon of "inattentional blindness," in which normal subjects intensely engaged in mental activity fail to notice salient but irrelevant sensory stimuli. Although highly simplified, the generic properties of a minimal network may help clarify some of the basic cerebral phenomena underlying the autonomy of consciousness.

Fire precautions at petroleum refineries and bulk storage installations

Energy Technology Data Exchange (ETDEWEB)

1993-10-01

Topics covered in this Code of Practice include petroleum products and combustion, site evaluation for fire defence, and fire prevention, protection, detection, systems, fighting, and fire fighting facilities in storage areas. Appendices cover legal requirements and enforcement arrangements, application rates for fire water and foam, codes of practice, flammable limits of petroleum compounds, flash points and spontaneous ignition temperatures and classification of fires. (UK)

Drought effects on large fire activity in Canadian and Alaskan forests

International Nuclear Information System (INIS)

Xiao Jingfeng; Zhuang Qianlai

2007-01-01

Fire is the dominant disturbance in forest ecosystems across Canada and Alaska, and has important implications for forest ecosystems, terrestrial carbon dioxide emissions and the forestry industry. Large fire activity had increased in Canadian and Alaskan forests during the last four decades of the 20th century. Here we combined the Palmer Drought Severity Index and historical large fire databases to demonstrate that Canada and Alaska forest regions experienced summer drying over this time period, and drought during the fire season significantly affected forest fire activity in these regions. Climatic warming, positive geopotential height anomalies and ocean circulation patterns were spatially and temporally convolved in causing drought conditions, which in turn enhanced fuel flammability and thereby indirectly affected fire activity. Future fire regimes will likely depend on drought patterns under global climate change scenarios

Uncovering intrinsic modular organization of spontaneous brain activity in humans.

Directory of Open Access Journals (Sweden)

Yong He

Full Text Available The characterization of topological architecture of complex brain networks is one of the most challenging issues in neuroscience. Slow (<0.1 Hz, spontaneous fluctuations of the blood oxygen level dependent (BOLD signal in functional magnetic resonance imaging are thought to be potentially important for the reflection of spontaneous neuronal activity. Many studies have shown that these fluctuations are highly coherent within anatomically or functionally linked areas of the brain. However, the underlying topological mechanisms responsible for these coherent intrinsic or spontaneous fluctuations are still poorly understood. Here, we apply modern network analysis techniques to investigate how spontaneous neuronal activities in the human brain derived from the resting-state BOLD signals are topologically organized at both the temporal and spatial scales. We first show that the spontaneous brain functional networks have an intrinsically cohesive modular structure in which the connections between regions are much denser within modules than between them. These identified modules are found to be closely associated with several well known functionally interconnected subsystems such as the somatosensory/motor, auditory, attention, visual, subcortical, and the "default" system. Specifically, we demonstrate that the module-specific topological features can not be captured by means of computing the corresponding global network parameters, suggesting a unique organization within each module. Finally, we identify several pivotal network connectors and paths (predominantly associated with the association and limbic/paralimbic cortex regions that are vital for the global coordination of information flow over the whole network, and we find that their lesions (deletions critically affect the stability and robustness of the brain functional system. Together, our results demonstrate the highly organized modular architecture and associated topological properties in

Sustained increase of spontaneous input and spike transfer in the CA3-CA1 pathway following long term potentiation in vivo

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Oscar eHerreras

2012-10-01

Full Text Available Long term potentiation (LTP is commonly used to study synaptic plasticity but the associated changes in the spontaneous activity of individual neurons or the computational properties of neural networks in vivo remain largely unclear. The multisynaptic origin of spontaneous spikes makes difficult estimating the impact of a particular potentiated input. Accordingly, we adopted an approach that isolates pathway-specific postsynaptic activity from raw local field potentials (LFPs in the rat hippocampus in order to study the effects of LTP on ongoing spike transfer between cell pairs in the CA3-CA1 pathway. CA1 Schaffer-specific LFPs elicited by spontaneous clustered firing of CA3 pyramidal cells involved a regular succession of elementary micro-field-EPSPs (gamma-frequency that fired spikes in CA1 units. LTP increased the amplitude but not the frequency of these ongoing excitatory quanta. Also, the proportion of Schaffer-driven spikes in both CA1 pyramidal cells and interneurons increased in a cell-specific manner only in previously connected CA3-CA1 cell pairs, i.e., when the CA3 pyramidal cell had shown pre-LTP significant correlation with firing of a CA1 unit and potentiated spike-triggered average of Schaffer LFPs following LTP. Moreover, LTP produced subtle reorganization of presynaptic CA3 cell assemblies. These findings show effective enhancement of pathway specific ongoing activity which leads to increased spike transfer in potentiated segments of a network. These indicate that plastic phenomena induced by external protocols may intensify spontaneous information flow across specific channels as proposed in transsynaptic propagation of plasticity and synfire chain hypotheses that may be the substrate for different types of memory involving multiple brain structures.

Holocene fire activity and vegetation response in South-Eastern Iberia

Science.gov (United States)

Gil-Romera, Graciela; Carrión, José S.; Pausas, Juli G.; Sevilla-Callejo, Miguel; Lamb, Henry F.; Fernández, Santiago; Burjachs, Francesc

2010-05-01

Since fire has been recognized as an essential disturbance in Mediterranean landscapes, the study of long-term fire ecology has developed rapidly. We have reconstructed a sequence of vegetation dynamics and fire changes across south-eastern Iberia by coupling records of climate, fire, vegetation and human activities. We calculated fire activity anomalies (FAAs) in relation to 3 ka cal BP for 10-8 ka cal BP, 6 ka cal BP, 4 ka cal BP and the present. For most of the Early to the Mid-Holocene uneven, but low fire events were the main vegetation driver at high altitudes where broadleaved and coniferous trees presented a highly dynamic post-fire response. At mid-altitudes in the mainland Segura Mountains, fire activity remained relatively stable, at similar levels to recent times. We hypothesize that coastal areas, both mountains and lowlands, were more fire-prone landscapes as biomass was more likely to have accumulated than in the inland regions, triggering regular fire events. The wet and warm phase towards the Mid-Holocene (between ca 8 and 6 ka cal BP) affected the whole region and promoted the spread of mesophytic forest co-existing with Pinus, as FAAs appear strongly negative at 6 ka cal BP, with a less important role of fire. Mid and Late Holocene landscapes were shaped by an increasing aridity trend and the rise of human occupation, especially in the coastal mountains where forest disappeared from ca 2 ka cal BP. Mediterranean-type vegetation (evergreen oaks and Pinus pinaster- halepensis types) showed the fastest post-fire vegetation dynamics over time.

Atlantic SSTs control regime shifts in forest fire activity of Northern Scandinavia

Science.gov (United States)

Drobyshev, Igor; Bergeron, Yves; Vernal, Anne De; Moberg, Anders; Ali, Adam A.; Niklasson, Mats

2016-03-01

Understanding the drivers of the boreal forest fire activity is challenging due to the complexity of the interactions driving fire regimes. We analyzed drivers of forest fire activity in Northern Scandinavia (above 60 N) by combining modern and proxy data over the Holocene. The results suggest that the cold climate in northern Scandinavia was generally characterized by dry conditions favourable to periods of regionally increased fire activity. We propose that the cold conditions over the northern North Atlantic, associated with low SSTs, expansion of sea ice cover, and the southward shift in the position of the subpolar gyre, redirect southward the precipitation over Scandinavia, associated with the westerlies. This dynamics strengthens high pressure systems over Scandinavia and results in increased regional fire activity. Our study reveals a previously undocumented teleconnection between large scale climate and ocean dynamics over the North Atlantic and regional boreal forest fire activity in Northern Scandinavia. Consistency of the pattern observed annually through millennium scales suggests that a strong link between Atlantic SST and fire activity on multiple temporal scales over the entire Holocene is relevant for understanding future fire activity across the European boreal zone.

Atlantic SSTs control regime shifts in forest fire activity of Northern Scandinavia

Science.gov (United States)

Drobyshev, Igor; Bergeron, Yves; Vernal, Anne de; Moberg, Anders; Ali, Adam A.; Niklasson, Mats

2016-01-01

Understanding the drivers of the boreal forest fire activity is challenging due to the complexity of the interactions driving fire regimes. We analyzed drivers of forest fire activity in Northern Scandinavia (above 60 N) by combining modern and proxy data over the Holocene. The results suggest that the cold climate in northern Scandinavia was generally characterized by dry conditions favourable to periods of regionally increased fire activity. We propose that the cold conditions over the northern North Atlantic, associated with low SSTs, expansion of sea ice cover, and the southward shift in the position of the subpolar gyre, redirect southward the precipitation over Scandinavia, associated with the westerlies. This dynamics strengthens high pressure systems over Scandinavia and results in increased regional fire activity. Our study reveals a previously undocumented teleconnection between large scale climate and ocean dynamics over the North Atlantic and regional boreal forest fire activity in Northern Scandinavia. Consistency of the pattern observed annually through millennium scales suggests that a strong link between Atlantic SST and fire activity on multiple temporal scales over the entire Holocene is relevant for understanding future fire activity across the European boreal zone. PMID:26940995

The ducky2J mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression

Science.gov (United States)

Donato, Roberta; Page, Karen M.; Koch, Dietlind; Nieto-Rostro, Manuela; Foucault, Isabelle; Davies, Anthony; Wilkinson, Tonia; Rees, Michele; Edwards, Frances A.; Dolphin, Annette C.

2006-01-01

The mouse mutant ducky and its allele ducky2J represent a model for absence epilepsy characterized by spike-wave seizures, and cerebellar ataxia. These mice have mutations in Cacna2d2, which encodes the α2δ-2 calcium channel subunit. Of relevance to the ataxic phenotype, α2δ-2 mRNA is strongly expressed in cerebellar Purkinje cells (PCs). The Cacna2d2du2J mutation results in a two base-pair deletion in the coding region and a complete loss of α2δ-2 protein. Here we show that du2J/du2J mice have a 30% reduction in somatic calcium current, and a marked fall in the spontaneous PC firing rate at 22°C, accompanied by a decrease in firing regularity, which is not affected by blocking synaptic input to PCs. At 34°C du2J/du2J PCs show no spontaneous intrinsic activity. Du2J/du2J mice also have alterations in the cerebellar expression of several genes related to PC function. At P21 there is an elevation of tyrosine hydroxylase mRNA and a reduction in tenascin-C gene expression. Although du2J/+ mice have a marked reduction in α2δ-2 protein, they show no fall in PC somatic calcium currents or increase in cerebellar tryrosine hydroxylase gene expression. However, du2J/+ PCs do exhibit a significant reduction in firing rate, correlating with the reduction in α2δ-2. A hypothesis for future study is that effects on gene expression occur as a result of a reduction in somatic calcium currents, whereas effects on PC firing occur as a long-term result of loss of α2δ-2 and/or a reduction in calcium currents and calcium-dependent processes in regions other than the soma. PMID:17135419

High glucose increases action potential firing of catecholamine neurons in the nucleus of the solitary tract by increasing spontaneous glutamate inputs.

Science.gov (United States)

Roberts, Brandon L; Zhu, Mingyan; Zhao, Huan; Dillon, Crystal; Appleyard, Suzanne M

2017-09-01

Glucose is a crucial substrate essential for cell survival and function. Changes in glucose levels impact neuronal activity and glucose deprivation increases feeding. Several brain regions have been shown to respond to glucoprivation, including the nucleus of the solitary tract (NTS) in the brain stem. The NTS is the primary site in the brain that receives visceral afferent information from the gastrointestinal tract. The catecholaminergic (CA) subpopulation within the NTS modulates many homeostatic functions including cardiovascular reflexes, respiration, food intake, arousal, and stress. However, it is not known if they respond to changes in glucose. Here we determined whether NTS-CA neurons respond to changes in glucose concentration and the mechanism involved. We found that decreasing glucose concentrations from 5 mM to 2 mM to 1 mM, significantly decreased action potential firing in a cell-attached preparation, whereas increasing it back to 5 mM increased the firing rate. This effect was dependent on glutamate release from afferent terminals and required presynaptic 5-HT 3 Rs. Decreasing the glucose concentration also decreased both basal and 5-HT 3 R agonist-induced increase in the frequency of spontaneous glutamate inputs onto NTS-CA neurons. Low glucose also blunted 5-HT-induced inward currents in nodose ganglia neurons, which are the cell bodies of vagal afferents. The effect of low glucose in both nodose ganglia cells and in NTS slices was mimicked by the glucokinase inhibitor glucosamine. This study suggests that NTS-CA neurons are glucosensing through a presynaptic mechanism that is dependent on vagal glutamate release, 5-HT 3 R activity, and glucokinase. Copyright © 2017 the American Physiological Society.

Embedding responses in spontaneous neural activity shaped through sequential learning.

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Tomoki Kurikawa

Full Text Available Recent experimental measurements have demonstrated that spontaneous neural activity in the absence of explicit external stimuli has remarkable spatiotemporal structure. This spontaneous activity has also been shown to play a key role in the response to external stimuli. To better understand this role, we proposed a viewpoint, "memories-as-bifurcations," that differs from the traditional "memories-as-attractors" viewpoint. Memory recall from the memories-as-bifurcations viewpoint occurs when the spontaneous neural activity is changed to an appropriate output activity upon application of an input, known as a bifurcation in dynamical systems theory, wherein the input modifies the flow structure of the neural dynamics. Learning, then, is a process that helps create neural dynamical systems such that a target output pattern is generated as an attractor upon a given input. Based on this novel viewpoint, we introduce in this paper an associative memory model with a sequential learning process. Using a simple hebbian-type learning, the model is able to memorize a large number of input/output mappings. The neural dynamics shaped through the learning exhibit different bifurcations to make the requested targets stable upon an increase in the input, and the neural activity in the absence of input shows chaotic dynamics with occasional approaches to the memorized target patterns. These results suggest that these dynamics facilitate the bifurcations to each target attractor upon application of the corresponding input, which thus increases the capacity for learning. This theoretical finding about the behavior of the spontaneous neural activity is consistent with recent experimental observations in which the neural activity without stimuli wanders among patterns evoked by previously applied signals. In addition, the neural networks shaped by learning properly reflect the correlations of input and target-output patterns in a similar manner to those designed in

Presbycusis Disrupts Spontaneous Activity Revealed by Resting-State Functional MRI

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Yu-Chen Chen

2018-03-01

Full Text Available Purpose: Presbycusis, age-related hearing loss, is believed to involve neural changes in the central nervous system, which is associated with an increased risk of cognitive impairment. The goal of this study was to determine if presbycusis disrupted spontaneous neural activity in specific brain areas involved in auditory processing, attention and cognitive function using resting-state functional magnetic resonance imaging (fMRI approach.Methods: Hearing and resting-state fMRI measurements were obtained from 22 presbycusis patients and 23 age-, sex- and education-matched healthy controls. To identify changes in spontaneous neural activity associated with age-related hearing loss, we compared the amplitude of low-frequency fluctuations (ALFF and regional homogeneity (ReHo of fMRI signals in presbycusis patients vs. controls and then determined if these changes were linked to clinical measures of presbycusis.Results: Compared with healthy controls, presbycusis patients manifested decreased spontaneous activity mainly in the superior temporal gyrus (STG, parahippocampal gyrus (PHG, precuneus and inferior parietal lobule (IPL as well as increased neural activity in the middle frontal gyrus (MFG, cuneus and postcentral gyrus (PoCG. A significant negative correlation was observed between ALFF/ReHo activity in the STG and average hearing thresholds in presbycusis patients. Increased ALFF/ReHo activity in the MFG was positively correlated with impaired Trail-Making Test B (TMT-B scores, indicative of impaired cognitive function involving the frontal lobe.Conclusions: Presbycusis patients have disrupted spontaneous neural activity reflected by ALFF and ReHo measurements in several brain regions; these changes are associated with specific cognitive performance and speech/language processing. These findings mainly emphasize the crucial role of aberrant resting-state ALFF/ReHo patterns in presbycusis patients and will lead to a better understanding of the

Presbycusis Disrupts Spontaneous Activity Revealed by Resting-State Functional MRI.

Science.gov (United States)

Chen, Yu-Chen; Chen, Huiyou; Jiang, Liang; Bo, Fan; Xu, Jin-Jing; Mao, Cun-Nan; Salvi, Richard; Yin, Xindao; Lu, Guangming; Gu, Jian-Ping

2018-01-01

Purpose : Presbycusis, age-related hearing loss, is believed to involve neural changes in the central nervous system, which is associated with an increased risk of cognitive impairment. The goal of this study was to determine if presbycusis disrupted spontaneous neural activity in specific brain areas involved in auditory processing, attention and cognitive function using resting-state functional magnetic resonance imaging (fMRI) approach. Methods : Hearing and resting-state fMRI measurements were obtained from 22 presbycusis patients and 23 age-, sex- and education-matched healthy controls. To identify changes in spontaneous neural activity associated with age-related hearing loss, we compared the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) of fMRI signals in presbycusis patients vs. controls and then determined if these changes were linked to clinical measures of presbycusis. Results : Compared with healthy controls, presbycusis patients manifested decreased spontaneous activity mainly in the superior temporal gyrus (STG), parahippocampal gyrus (PHG), precuneus and inferior parietal lobule (IPL) as well as increased neural activity in the middle frontal gyrus (MFG), cuneus and postcentral gyrus (PoCG). A significant negative correlation was observed between ALFF/ReHo activity in the STG and average hearing thresholds in presbycusis patients. Increased ALFF/ReHo activity in the MFG was positively correlated with impaired Trail-Making Test B (TMT-B) scores, indicative of impaired cognitive function involving the frontal lobe. Conclusions : Presbycusis patients have disrupted spontaneous neural activity reflected by ALFF and ReHo measurements in several brain regions; these changes are associated with specific cognitive performance and speech/language processing. These findings mainly emphasize the crucial role of aberrant resting-state ALFF/ReHo patterns in presbycusis patients and will lead to a better understanding of the

Endogenous activation of adenosine A(1) receptors accelerates ischemic suppression of spontaneous electrocortical activity

DEFF Research Database (Denmark)

Ilie, Andrei; Ciocan, Dragos; Zagrean, Ana-Maria

2006-01-01

Cerebral ischemia induces a rapid suppression of spontaneous brain rhythms prior to major alterations in ionic homeostasis. It was found in vitro during ischemia that the rapidly formed adenosine, resulting from the intracellular breakdown of ATP, may inhibit synaptic transmission via the A(1......) receptor subtype. The link between endogenous A(1) receptor activation during ischemia and the suppression of spontaneous electrocortical activity has not yet been established in the intact brain. The aim of this study was to investigate in vivo the effects of A(1) receptor antagonism by 8-cyclopentyl-1...

Japan FRI research activities on oil tank/spilled oil fire

International Nuclear Information System (INIS)

Koseki, Hiroshi

1992-01-01

Introduction of research activities on oil tank/spilled oil fire at FRI, Japan is done. FRI has a long history of studying oil tank and spilled oil fires. Many large oil fire tests were done. The purpose of these studies is different with research of response of oil spill, but the accumulation of this knowledge is useful for conducting elimination of spilled oil on the sea with burning. Therefore to do collaboration with fire science research groups, such as FRI is useful for future activities for response to oil spills

Sensory memory for odors is encoded in spontaneous correlated activity between olfactory glomeruli.

Science.gov (United States)

Galán, Roberto F; Weidert, Marcel; Menzel, Randolf; Herz, Andreas V M; Galizia, C Giovanni

2006-01-01

Sensory memory is a short-lived persistence of a sensory stimulus in the nervous system, such as iconic memory in the visual system. However, little is known about the mechanisms underlying olfactory sensory memory. We have therefore analyzed the effect of odor stimuli on the first odor-processing network in the honeybee brain, the antennal lobe, which corresponds to the vertebrate olfactory bulb. We stained output neurons with a calcium-sensitive dye and measured across-glomerular patterns of spontaneous activity before and after a stimulus. Such a single-odor presentation changed the relative timing of spontaneous activity across glomeruli in accordance with Hebb's theory of learning. Moreover, during the first few minutes after odor presentation, correlations between the spontaneous activity fluctuations suffice to reconstruct the stimulus. As spontaneous activity is ubiquitous in the brain, modifiable fluctuations could provide an ideal substrate for Hebbian reverberations and sensory memory in other neural systems.

Large-Scale Controls and Characteristics of Fire Activity in Central Chile, 2001-2015

Science.gov (United States)

McWethy, D. B.; Pauchard, A.; García, R.; Holz, A.; González, M.; Veblen, T. T.; Stahl, J.

2016-12-01

In recent decades, fire activity has increased in many ecosystems worldwide, even where fuel conditions and natural ignitions historically limited fire activity, and this increase begs questions of whether climate change, land-use change, and/or altered vegetation are responsible. Increased frequency of large fires in these settings has been attributed to drier-than-average summers and longer fire seasons as well as fuel accumulation related to ENSO events, raising concerns about the trajectory of post-fire vegetation dynamics and future fire regimes. In temperate and Mediterranean forests of central Chile, recent large fires associated with altered ecosystems, climate variability and land-use change highlight the risk and hazard of increasing fire activity yet the causes and consequences are poorly understood. To better understand characteristics of recent fire activity, key drivers of fire occurrence and the spatial probability of wildfire we examined the relationship between fire activity derived from MODIS satellite imagery and biophysical, land-cover and land-use variables. The probability of fire occurrence and annual area burned was best predicted by seasonal precipitation, annual temperature and land cover type. The likelihood of fire occurrence was greatest in Matorral shrublands, agricultural lands (including pasture lands) and Pinus and Eucalyptus plantations, highlighting the importance of vegetation type and fuel flammability as a critical control on fire activity. Our results suggest that land-use change responsible for the widespread presence of highly flammable vegetation and projections for continued warming and drying will likely combine to promote the occurrence of large fires in central Chile in the future.

Fire activity increasing as climate changes

Science.gov (United States)

Balcerak, Ernie; Showstack, Randy

2013-01-01

Analysis of images from NASA's Moderate Resolution Imaging Spectroradiometer (MODIS) satellites shows that more than 2.5 million hectares were burned in 2012 from January through August in the United States. The amount is less than a record 3.2 million hectares in 2011 but greater than the area burned in 12 of 15 years since satellite monitoring began, scientists reported at the AGU Fall Meeting. With satellites "we can detect fires as they're actively burning," said Louis Giglio of the University of Maryland, College Park, at a press conference on 4 December. "We can also map the cumulative area burned on the landscape after the fire's over." He noted that "2012 has been a particularly big fire year" in the United States.

Soil nitrogen mineralization and enzymatic activities in fire and fire surrogate treatments in California

Science.gov (United States)

J. R. Miesel; R. E. J. Boerner; C. N. Skinner

2011-01-01

Forest thinning and prescribed fire are management strategies used to reduce hazardous fuel loads and catastrophic wildfires in western mixed-conifer forests. We evaluated effects of thinning (Thin) and prescribed fire (Burn), alone and in combination (Thin+Burn), on N transformations and microbial enzyme activities relative to an untreated control (Control) at 1 and 3...

Functional structure of spontaneous sleep slow oscillation activity in humans.

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Danilo Menicucci

Full Text Available BACKGROUND: During non-rapid eye movement (NREM sleep synchronous neural oscillations between neural silence (down state and neural activity (up state occur. Sleep Slow Oscillations (SSOs events are their EEG correlates. Each event has an origin site and propagates sweeping the scalp. While recent findings suggest a SSO key role in memory consolidation processes, the structure and the propagation of individual SSO events, as well as their modulation by sleep stages and cortical areas have not been well characterized so far. METHODOLOGY/PRINCIPAL FINDINGS: We detected SSO events in EEG recordings and we defined and measured a set of features corresponding to both wave shapes and event propagations. We found that a typical SSO shape has a transition to down state, which is steeper than the following transition from down to up state. We show that during SWS SSOs are larger and more locally synchronized, but less likely to propagate across the cortex, compared to NREM stage 2. Also, the detection number of SSOs as well as their amplitudes and slopes, are greatest in the frontal regions. Although derived from a small sample, this characterization provides a preliminary reference about SSO activity in healthy subjects for 32-channel sleep recordings. CONCLUSIONS/SIGNIFICANCE: This work gives a quantitative picture of spontaneous SSO activity during NREM sleep: we unveil how SSO features are modulated by sleep stage, site of origin and detection location of the waves. Our measures on SSOs shape indicate that, as in animal models, onsets of silent states are more synchronized than those of neural firing. The differences between sleep stages could be related to the reduction of arousal system activity and to the breakdown of functional connectivity. The frontal SSO prevalence could be related to a greater homeostatic need of the heteromodal association cortices.

Voluntary breath holding affects spontaneous brain activity measured by magnetoencephalography

NARCIS (Netherlands)

Schellart, N. A.; Reits, D.

1999-01-01

Spontaneous brain activity was measured by multichannel magnetoencephalography (MEG) during voluntary breath holds. Significant changes in the activity are limited to the alpha rhythm: 0.25 Hz frequency increase and narrowing of the peak. The area of alpha activity shifts slightly toward (fronto-)

Spatial and Temporal Variability and Trends in 2001-2016 Global Fire Activity

Science.gov (United States)

Earl, Nick; Simmonds, Ian

2018-03-01

Fire regimes across the globe have great spatial and temporal variability, and these are influence by many factors including anthropogenic management, climate, and vegetation types. Here we utilize the satellite-based "active fire" product, from Moderate Resolution Imaging Spectroradiometer (MODIS) sensors, to statistically analyze variability and trends in fire activity from the global to regional scales. We split up the regions by economic development, region/geographical land use, clusters of fire-abundant areas, or by religious/cultural influence. Weekly cycle tests are conducted to highlight and quantify part of the anthropogenic influence on fire regime across the world. We find that there is a strong statistically significant decline in 2001-2016 active fires globally linked to an increase in net primary productivity observed in northern Africa, along with global agricultural expansion and intensification, which generally reduces fire activity. There are high levels of variability, however. The large-scale regions exhibit either little change or decreasing in fire activity except for strong increasing trends in India and China, where rapid population increase is occurring, leading to agricultural intensification and increased crop residue burning. Variability in Canada has been linked to a warming global climate leading to a longer growing season and higher fuel loads. Areas with a strong weekly cycle give a good indication of where fire management is being applied most extensively, for example, the United States, where few areas retain a natural fire regime.

Atlantic SSTs control regime shifts in forest fire activity of Northern Scandinavia

OpenAIRE

Drobyshev, Igor; Bergeron, Yves; Vernal, Anne de; Moberg, Anders; Ali, Adam A.; Niklasson, Mats

2016-01-01

Understanding the drivers of the boreal forest fire activity is challenging due to the complexity of the interactions driving fire regimes. We analyzed drivers of forest fire activity in Northern Scandinavia (above 60 N) by combining modern and proxy data over the Holocene. The results suggest that the cold climate in northern Scandinavia was generally characterized by dry conditions favourable to periods of regionally increased fire activity. We propose that the cold conditions over the nort...

Phasic firing in vasopressin cells: understanding its functional significance through computational models.

Directory of Open Access Journals (Sweden)

Duncan J MacGregor

Full Text Available Vasopressin neurons, responding to input generated by osmotic pressure, use an intrinsic mechanism to shift from slow irregular firing to a distinct phasic pattern, consisting of long bursts and silences lasting tens of seconds. With increased input, bursts lengthen, eventually shifting to continuous firing. The phasic activity remains asynchronous across the cells and is not reflected in the population output signal. Here we have used a computational vasopressin neuron model to investigate the functional significance of the phasic firing pattern. We generated a concise model of the synaptic input driven spike firing mechanism that gives a close quantitative match to vasopressin neuron spike activity recorded in vivo, tested against endogenous activity and experimental interventions. The integrate-and-fire based model provides a simple physiological explanation of the phasic firing mechanism involving an activity-dependent slow depolarising afterpotential (DAP generated by a calcium-inactivated potassium leak current. This is modulated by the slower, opposing, action of activity-dependent dendritic dynorphin release, which inactivates the DAP, the opposing effects generating successive periods of bursting and silence. Model cells are not spontaneously active, but fire when perturbed by random perturbations mimicking synaptic input. We constructed one population of such phasic neurons, and another population of similar cells but which lacked the ability to fire phasically. We then studied how these two populations differed in the way that they encoded changes in afferent inputs. By comparison with the non-phasic population, the phasic population responds linearly to increases in tonic synaptic input. Non-phasic cells respond to transient elevations in synaptic input in a way that strongly depends on background activity levels, phasic cells in a way that is independent of background levels, and show a similar strong linearization of the response

Post-fire recovery of torpor and activity patterns of a small mammal.

Science.gov (United States)

Stawski, Clare; Hume, Taylor; Körtner, Gerhard; Currie, Shannon E; Nowack, Julia; Geiser, Fritz

2017-05-01

To cope with the post-fire challenges of decreased availability of food and shelter, brown antechinus ( Antechinus stuartii ), a small marsupial mammal, increase the use of energy-conserving torpor and reduce activity. However, it is not known how long it takes for animals to resume pre-fire torpor and activity patterns during the recovery of burnt habitat. Therefore, we tested the hypothesis that antechinus will adjust torpor use and activity after a fire depending on vegetation recovery. We simultaneously quantified torpor and activity patterns for female antechinus from three adjacent areas: (i) the area of a management burn 1 year post-fire, (ii) an area that was burned 2 years prior, and (iii) a control area. In comparison to shortly after the management burn, antechinus in all three groups displayed less frequent and less pronounced torpor while being more active. We provide the first evidence that only 1 year post-fire antechinus resume pre-fire torpor and activity patterns, probably in response to the return of herbaceous ground cover and foraging opportunities. © 2017 The Author(s).

Evaluating the SEVIRI Fire Thermal Anomaly Detection Algorithm across the Central African Republic Using the MODIS Active Fire Product

Directory of Open Access Journals (Sweden)

Patrick H. Freeborn

2014-02-01

Full Text Available Satellite-based remote sensing of active fires is the only practical way to consistently and continuously monitor diurnal fluctuations in biomass burning from regional, to continental, to global scales. Failure to understand, quantify, and communicate the performance of an active fire detection algorithm, however, can lead to improper interpretations of the spatiotemporal distribution of biomass burning, and flawed estimates of fuel consumption and trace gas and aerosol emissions. This work evaluates the performance of the Spinning Enhanced Visible and Infrared Imager (SEVIRI Fire Thermal Anomaly (FTA detection algorithm using seven months of active fire pixels detected by the Moderate Resolution Imaging Spectroradiometer (MODIS across the Central African Republic (CAR. Results indicate that the omission rate of the SEVIRI FTA detection algorithm relative to MODIS varies spatially across the CAR, ranging from 25% in the south to 74% in the east. In the absence of confounding artifacts such as sunglint, uncertainties in the background thermal characterization, and cloud cover, the regional variation in SEVIRI’s omission rate can be attributed to a coupling between SEVIRI’s low spatial resolution detection bias (i.e., the inability to detect fires below a certain size and intensity and a strong geographic gradient in active fire characteristics across the CAR. SEVIRI’s commission rate relative to MODIS increases from 9% when evaluated near MODIS nadir to 53% near the MODIS scene edges, indicating that SEVIRI errors of commission at the MODIS scene edges may not be false alarms but rather true fires that MODIS failed to detect as a result of larger pixel sizes at extreme MODIS scan angles. Results from this work are expected to facilitate (i future improvements to the SEVIRI FTA detection algorithm; (ii the assimilation of the SEVIRI and MODIS active fire products; and (iii the potential inclusion of SEVIRI into a network of geostationary

Altered spontaneous activity in anisometropic amblyopia subjects: revealed by resting-state FMRI.

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Xiaoming Lin

Full Text Available Amblyopia, also known as lazy eye, usually occurs during early childhood and results in poor or blurred vision. Recent neuroimaging studies have found cortical structural/functional abnormalities in amblyopia. However, until now, it was still not known whether the spontaneous activity of the brain changes in amblyopia subjects. In the present study, regional homogeneity (ReHo, a measure of the homogeneity of functional magnetic resonance imaging signals, was used for the first time to investigate changes in resting-state local spontaneous brain activity in individuals with anisometropic amblyopia. Compared with age- and gender-matched subjects with normal vision, the anisometropic amblyopia subjects showed decreased ReHo of spontaneous brain activity in the right precuneus, the left medial prefrontal cortex, the left inferior frontal gyrus, and the left cerebellum, and increased ReHo of spontaneous brain activity was found in the bilateral conjunction area of the postcentral and precentral gyri, the left paracentral lobule, the left superior temporal gyrus, the left fusiform gyrus, the conjunction area of the right insula, putamen and the right middle occipital gyrus. The observed decreases in ReHo may reflect decreased visuo-motor processing ability, and the increases in ReHo in the somatosensory cortices, the motor areas and the auditory area may indicate compensatory plasticity in amblyopia.

Forest fires and lightning activity during the outstanding 2003 and 2005 fire seasons

Science.gov (United States)

Russo, Ana; Ramos, Alexandre; Trigo, Ricardo

2013-04-01

Wildfires in southern Europe cause frequent extensive economical and ecological losses and, even human casualties. Comparatively to other Mediterranean countries, Portugal is the country with more burnt area and fires per unit area in the last decade, mainly during the summer season (Pereira et al., 2011). According to the fire records available, between 1980 and 2009, wildfires have affected over 3 million hectares in Portugal (JRC, 2011), which corresponds to approximately a third of the Portuguese Continental territory. The main factors that influence fire ignition and propagation are: (1) the presence of fuel (i.e. vegetation); (2) climate and weather; (3) socioeconomic conditions that affect land use/land cover patterns, fire-prevention and fire-fighting capacity and (4) topography. Specifically, weather (e.g. wind, temperature, precipitation, humidity, and lightning occurrence) plays an important role in fire behavior, affecting both ignition and spread of wildfires. Some countries have a relatively large fraction of fires caused by lightning, e.g. northwestern USA, Canada, Russia (). In contrast, Portugal has only a small percentage of fire records caused by lightning. Although significant doubts remain for the majority of fires in the catalog since they were cataloged without a likely cause. The recent years of 2003 and 2005 were particularly outstanding for fire activity in Portugal, registering, respectively, total burned areas of 425 726 ha and 338 262 ha. However, while the 2003 was triggered by an exceptional heatwave that struck the entire western Europe, the 2005 fire season registered was coincident with one of the most severe droughts of the 20th century. In this work we have used mainly two different databases: 1) the Portuguese Rural Fire Database (PRFD) which is representative of rural fires that have occurred in Continental Portugal, 2001-2011, with the original data provided by the Autoridade Florestal Nacional (AFN, 2011); 2) lightning

Coupling Strength and System Size Induce Firing Activity of Globally Coupled Neural Network

International Nuclear Information System (INIS)

Wei Duqu; Luo Xiaoshu; Zou Yanli

2008-01-01

We investigate how firing activity of globally coupled neural network depends on the coupling strength C and system size N. Network elements are described by space-clamped FitzHugh-Nagumo (SCFHN) neurons with the values of parameters at which no firing activity occurs. It is found that for a given appropriate coupling strength, there is an intermediate range of system size where the firing activity of globally coupled SCFHN neural network is induced and enhanced. On the other hand, for a given intermediate system size level, there exists an optimal value of coupling strength such that the intensity of firing activity reaches its maximum. These phenomena imply that the coupling strength and system size play a vital role in firing activity of neural network

The Application for a Prediction of the Coal Spontaneous Ignition - Predisam

Science.gov (United States)

Moni, Vlastimil; Klouda, Petr; Blata, Jan; Helebrant, František

2017-06-01

The article follows the research of the project number TA01020351 called "The research of possibilities when predicting steam origin and consequent spontaneous ignition of brown coal fuels" which was researched with the support of the Technological Agency in the Czech Republic in 2011-2014 in the connection with a realized technical research. Therefore, it gives a summary information about the evaluation of the risk degree for the origin of spontaneous ignitions of the brown coal. The presented way of evaluation is based on a numeric expression of a value for MHU criteria - the point load of particular indicators is added together with other results gained from this research project. Then, more information is taken from companies running the dumps of brown coal products - both for suppliers (mining companies) and big consumers (power engineering). The complex knowledge about prediction of the origin of the spontaneous ignition enables to make an early response to eliminate a threat of mining fire in open pit mines or on the dumps of coal products. Consequently, it reduces the risk of fire and breakdowns of transportation means DPD, heavy machines and preparation plants. The working injuries are reduced as well - burns by coal in fire or inhalation of gas products from imperfect combustion.

A new website with real-time dissemination of information on fire activity and meteorological fire danger in Portugal

Science.gov (United States)

DaCamara, Carlos; Trigo, Ricardo; Nunes, Sílvia; Pinto, Miguel; Oliveira, Tiago; Almeida, Rui

2017-04-01

In Portugal, like in Mediterranean Europe, fire activity is a natural phenomenon linking climate, humans and vegetation and is therefore conditioned by natural and anthropogenic factors. Natural factors include topography, vegetation cover and prevailing weather conditions whereas anthropogenic factors encompass land management practices and fire prevention policies. Land management practices, in particular the inadequate use of fire, is a crucial anthropogenic factor that accounts for about 90% of fire ignitions. Fire prevention policies require adequate and timely information about wildfire potential assessment, which is usually based on fire danger rating systems that provide indices to be used on an operational and tactical basis in decision support systems. We present a new website designed to provide the user community with relevant real-time information on fire activity and meteorological fire danger that will allow adopting the adequate measures to mitigate fire damage. The fire danger product consists of forecasts of fire danger over Portugal based on a statistical procedure that combines information about fire history derived from the Fire Radiative Power product disseminated by the Land Surface Analysis Satellite Application Facility (LSA SAF) with daily meteorological forecasts provided by the European Centre for Medium-Range Weather Forecasts (ECMWF). The aim of the website is fourfold; 1) to concentrate all information available (databases and maps) relevant to fire management in a unique platform so that access by end users becomes easier, faster and friendlier; 2) to supervise the access of users to the different products available; 3) to control and assist the access to the platform and obtain feedbacks from users for further improvements; 4) to outreach the operational community and foster the use of better information that increase efficiency in risk management. The website is sponsored by The Navigator Company, a leading force in the global pulp

Mine shaft fire and smoke protection systems - an update on hardware development and in-mine testing

International Nuclear Information System (INIS)

Johnson, G.A.

1982-01-01

In 1976, The Bureau of Mines developed a prototype system to sense and extinguish fires in shafts and shaft stations in underground metal and nonmetal mines. Subsequent work modified this technology to include fueling areas, spontaneous combustion zones and coal mines. This paper updates IC-8783 ''In-mine Fire Tests of Mine Shaft Fire and Smoke Protection Systems'', which was published in 1978 and summarized the design and in-mine, actual fire testing of the first prototype mine shaft fire and smoke protection system. This paper also updates related work from IC-8775 ''Spontaneous Oxidation and Combustion of Sulfide Ores in Underground Mines, (also published in 1978) and IC-8808 ''In-mine Evaluation of Underground Fire and Smoke Detectors'', (published in early 1979)

Synchronous fire activity in the tropical high Andes: an indication of regional climate forcing.

Science.gov (United States)

Román-Cuesta, R M; Carmona-Moreno, C; Lizcano, G; New, M; Silman, M; Knoke, T; Malhi, Y; Oliveras, I; Asbjornsen, H; Vuille, M

2014-06-01

Global climate models suggest enhanced warming of the tropical mid and upper troposphere, with larger temperature rise rates at higher elevations. Changes in fire activity are amongst the most significant ecological consequences of rising temperatures and changing hydrological properties in mountainous ecosystems, and there is a global evidence of increased fire activity with elevation. Whilst fire research has become popular in the tropical lowlands, much less is known of the tropical high Andean region (>2000 masl, from Colombia to Bolivia). This study examines fire trends in the high Andes for three ecosystems, the Puna, the Paramo and the Yungas, for the period 1982-2006. We pose three questions: (i) is there an increased fire response with elevation? (ii) does the El Niño- Southern Oscillation control fire activity in this region? (iii) are the observed fire trends human driven (e.g., human practices and their effects on fuel build-up) or climate driven? We did not find evidence of increased fire activity with elevation but, instead, a quasicyclic and synchronous fire response in Ecuador, Peru and Bolivia, suggesting the influence of high-frequency climate forcing on fire responses on a subcontinental scale, in the high Andes. ENSO variability did not show a significant relation to fire activity for these three countries, partly because ENSO variability did not significantly relate to precipitation extremes, although it strongly did to temperature extremes. Whilst ENSO did not individually lead the observed regional fire trends, our results suggest a climate influence on fire activity, mainly through a sawtooth pattern of precipitation (increased rainfall before fire-peak seasons (t-1) followed by drought spells and unusual low temperatures (t0), which is particularly common where fire is carried by low fuel loads (e.g., grasslands and fine fuel). This climatic sawtooth appeared as the main driver of fire trends, above local human influences and fuel build

Trends and drivers of fire activity vary across California aridland ecosystems

Science.gov (United States)

Syphard, Alexandra D.; Keeley, Jon E.; Abatzoglou, John T.

2017-01-01

Fire activity has increased in western US aridland ecosystems due to increased human-caused ignitions and the expansion of flammable exotic grasses. Because many desert plants are not adapted to fire, increased fire activity may have long-lasting ecological impacts on native vegetation and the wildlife that depend on it. Given the heterogeneity across aridland ecosystems, it is important to understand how trends and drivers of fire vary, so management can be customized accordingly. We examined historical trends and quantified the relative importance of and interactions among multiple drivers of fire patterns across five aridland ecoregions in southeastern California from 1970 to 2010. Fire frequency increased across all ecoregions for the first couple decades, and declined or plateaued since the 1990s; but area burned continued to increase in some regions. The relative importance of anthropogenic and biophysical drivers varied across ecoregions, with both direct and indirect influences on fire. Anthropogenic variables were equally important as biophysical variables, but some contributed indirectly, presumably via their influence on annual grass distribution and abundance. Grass burned disproportionately more than other cover types, suggesting that addressing exotics may be the key to fire management and conservation in much of the area.

Fire Effects on Microbial Enzyme Activities in Larch Forests of the Siberian Arctic

Science.gov (United States)

Ludwig, S.; Alexander, H. D.; Bulygina, E. B.; Mann, P. J.; Natali, S.

2012-12-01

Arctic forest ecosystems are warming at an accelerated rate relative to lower latitudes, with global implications for C cycling within these regions. As climate continues to warm and dry, wildfire frequency and severity are predicted to increase, creating a positive feedback to climate warming. Increased fire activity will also influence the microenvironment experienced by soil microbes in disturbed soils. Because soil microbes regulate carbon (C) and nitrogen (N) cycling between terrestrial ecosystems and the atmosphere, it is important to understand microbial response to fires, particularly in the understudied larch forests in the Siberian Arctic. In this project, we created experimental burn plots in a mature larch forest in the Kolyma River watershed of Northeastern Siberia. Plots were burned at several treatments: control (no burn), low, moderate, and severe. After, 1 and 8 d post-fire, we measured soil organic layer depth, soil organic matter (SOM) content, soil moisture, and CO2 flux from the plots. Additionally, we leached soils and measured dissolved organic carbon (DOC), total dissolved nitrogen (TDN), NH4, NO3, soluble reactive phosphorus (SRP), and chromophoric dissolved organic matter (CDOM). Furthermore, we measured extracellular activity of four enzymes involved in soil C and nutrient cycling (leucine aminopeptidase (LAP), β-glucosidase, phosphatase, and phenol oxidase). One day post-fire, LAP activity was similarly low in all treatments, but by 8 d post-fire, LAP activity was lower in burned plots compared to control plots, likely due to increased nitrogen content with increasing burn severity. Phosphatase activity decreased with burn severity 1 d post-fire, but after 8 d, moderate and severe burn plots exhibited increased phosphatase activity. Coupled with trends in LAP activity, this suggests a switch in nutrient limitation from N to phosphorus that is more pronounced with burn severity. β-glucosidase activity similarly decreased with burn

Perturbation analysis of spontaneous action potential initiation by stochastic ion channels

KAUST Repository

Keener, James P.

2011-07-01

A stochastic interpretation of spontaneous action potential initiation is developed for the Morris-Lecar equations. Initiation of a spontaneous action potential can be interpreted as the escape from one of the wells of a double well potential, and we develop an asymptotic approximation of the mean exit time using a recently developed quasistationary perturbation method. Using the fact that the activating ionic channel\\'s random openings and closings are fast relative to other processes, we derive an accurate estimate for the mean time to fire an action potential (MFT), which is valid for a below-threshold applied current. Previous studies have found that for above-threshold applied current, where there is only a single stable fixed point, a diffusion approximation can be used. We also explore why different diffusion approximation techniques fail to estimate the MFT. © 2011 American Physical Society.

Electrical responses and spontaneous activity of human iPS-derived neuronal networks characterized for three-month culture with 4096-electrode arrays

Directory of Open Access Journals (Sweden)

Hayder eAmin

2016-03-01

Full Text Available The recent availability of human induced pluripotent stem cells (hiPSCs holds great promise as a novel source of human-derived neurons for cell and tissue therapies as well as for in vitro drug screenings that might replace the use of animal models. However, there is still a considerable lack of knowledge on the functional properties of hiPSC-derived neuronal networks, thus limiting their application. Here, upon optimization of cell culture protocols, we demonstrate that both spontaneous and evoked electrical spiking activities of these networks can be characterized on-chip by taking advantage of the resolution provided by CMOS multielectrode arrays (CMOS-MEAs. These devices feature a large and closely-spaced array of 4096 simultaneously recording electrodes and multi-site on-chip electrical stimulation. Our results show that networks of human-derived neurons can respond to electrical stimulation with a physiological repertoire of spike waveforms after three months of cell culture, a period of time during which the network undergoes the expression of developing patterns of spontaneous spiking activity. To achieve this, we have investigated the impact on the network formation and on the emerging network-wide functional properties induced by different biochemical substrates, i.e. poly-dl-ornithine (PDLO, poly-l-ornithine (PLO, and polyethylenimine (PEI, that were used as adhesion promoters for the cell culture. Interestingly, we found that neuronal networks grown on PDLO coated substrates show significantly higher spontaneous firing activity, reliable responses to low-frequency electrical stimuli, and an appropriate level of PSD-95 that may denote a physiological neuronal maturation profile and synapse stabilization. However, our results also suggest that even three-month culture might not be sufficient for human-derived neuronal network maturation. Taken together, our results highlight the tight relationship existing between substrate coatings

Different responses of spontaneous and stimulus-related alpha activity to ambient luminance changes.

Science.gov (United States)

Benedetto, Alessandro; Lozano-Soldevilla, Diego; VanRullen, Rufin

2017-12-04

Alpha oscillations are particularly important in determining our percepts and have been implicated in fundamental brain functions. Oscillatory activity can be spontaneous or stimulus-related. Furthermore, stimulus-related responses can be phase- or non-phase-locked to the stimulus. Non-phase-locked (induced) activity can be identified as the average amplitude changes in response to a stimulation, while phase-locked activity can be measured via reverse-correlation techniques (echo function). However, the mechanisms and the functional roles of these oscillations are far from clear. Here, we investigated the effect of ambient luminance changes, known to dramatically modulate neural oscillations, on spontaneous and stimulus-related alpha. We investigated the effect of ambient luminance on EEG alpha during spontaneous human brain activity at rest (experiment 1) and during visual stimulation (experiment 2). Results show that spontaneous alpha amplitude increased by decreasing ambient luminance, while alpha frequency remained unaffected. In the second experiment, we found that under low-luminance viewing, the stimulus-related alpha amplitude was lower, and its frequency was slightly faster. These effects were evident in the phase-locked part of the alpha response (echo function), but weaker or absent in the induced (non-phase-locked) alpha responses. Finally, we explored the possible behavioural correlates of these modulations in a monocular critical flicker frequency task (experiment 3), finding that dark adaptation in the left eye decreased the temporal threshold of the right eye. Overall, we found that ambient luminance changes impact differently on spontaneous and stimulus-related alpha expression. We suggest that stimulus-related alpha activity is crucial in determining human temporal segmentation abilities. © 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

BK channels regulate spontaneous action potential rhythmicity in the suprachiasmatic nucleus.

Directory of Open Access Journals (Sweden)

Jack Kent

Full Text Available BACKGROUND: Circadian ( approximately 24 hr rhythms are generated by the central pacemaker localized to the suprachiasmatic nucleus (SCN of the hypothalamus. Although the basis for intrinsic rhythmicity is generally understood to rely on transcription factors encoded by "clock genes", less is known about the daily regulation of SCN neuronal activity patterns that communicate a circadian time signal to downstream behaviors and physiological systems. Action potentials in the SCN are necessary for the circadian timing of behavior, and individual SCN neurons modulate their spontaneous firing rate (SFR over the daily cycle, suggesting that the circadian patterning of neuronal activity is necessary for normal behavioral rhythm expression. The BK K(+ channel plays an important role in suppressing spontaneous firing at night in SCN neurons. Deletion of the Kcnma1 gene, encoding the BK channel, causes degradation of circadian behavioral and physiological rhythms. METHODOLOGY/PRINCIPAL FINDINGS: To test the hypothesis that loss of robust behavioral rhythmicity in Kcnma1(-/- mice is due to the disruption of SFR rhythms in the SCN, we used multi-electrode arrays to record extracellular action potentials from acute wild-type (WT and Kcnma1(-/- slices. Patterns of activity in the SCN were tracked simultaneously for up to 3 days, and the phase, period, and synchronization of SFR rhythms were examined. Loss of BK channels increased arrhythmicity but also altered the amplitude and period of rhythmic activity. Unexpectedly, Kcnma1(-/- SCNs showed increased variability in the timing of the daily SFR peak. CONCLUSIONS/SIGNIFICANCE: These results suggest that BK channels regulate multiple aspects of the circadian patterning of neuronal activity in the SCN. In addition, these data illustrate the characteristics of a disrupted SCN rhythm downstream of clock gene-mediated timekeeping and its relationship to behavioral rhythms.

Simulating wildfire spread behavior between two NASA Active Fire data timeframes

Science.gov (United States)

Adhikari, B.; Hodza, P.; Xu, C.; Minckley, T. A.

2017-12-01

Although NASA's Active Fire dataset is considered valuable in mapping the spatial distribution and extent of wildfires across the world, the data is only available at approximately 12-hour time intervals, creating uncertainties and risks associated with fire spread and behavior between the two Visible Infrared Imaging Radiometer Satellite (VIIRS) data collection timeframes. Our study seeks to close the information gap for the United States by using the latest Active Fire data collected for instance around 0130 hours as an ignition source and critical inputs to a wildfire model by uniquely incorporating forecasted and real-time weather conditions for predicting fire perimeter at the next 12 hour reporting time (i.e. around 1330 hours). The model ingests highly dynamic variables such as fuel moisture, temperature, relative humidity, wind among others, and prompts a Monte Carlo simulation exercise that uses a varying range of possible values for evaluating all possible wildfire behaviors. The Monte Carlo simulation implemented in this model provides a measure of the relative wildfire risk levels at various locations based on the number of times those sites are intersected by simulated fire perimeters. Model calibration is achieved using data at next reporting time (i.e. after 12 hours) to enhance the predictive quality at further time steps. While initial results indicate that the calibrated model can predict the overall geometry and direction of wildland fire spread, the model seems to over-predict the sizes of most fire perimeters possibly due to unaccounted fire suppression activities. Nonetheless, the results of this study show great promise in aiding wildland fire tracking, fighting and risk management.

Oscillatory brain activity in spontaneous and induced sleep stages in flies.

Science.gov (United States)

Yap, Melvyn H W; Grabowska, Martyna J; Rohrscheib, Chelsie; Jeans, Rhiannon; Troup, Michael; Paulk, Angelique C; van Alphen, Bart; Shaw, Paul J; van Swinderen, Bruno

2017-11-28

Sleep is a dynamic process comprising multiple stages, each associated with distinct electrophysiological properties and potentially serving different functions. While these phenomena are well described in vertebrates, it is unclear if invertebrates have distinct sleep stages. We perform local field potential (LFP) recordings on flies spontaneously sleeping, and compare their brain activity to flies induced to sleep using either genetic activation of sleep-promoting circuitry or the GABA A agonist Gaboxadol. We find a transitional sleep stage associated with a 7-10 Hz oscillation in the central brain during spontaneous sleep. Oscillatory activity is also evident when we acutely activate sleep-promoting neurons in the dorsal fan-shaped body (dFB) of Drosophila. In contrast, sleep following Gaboxadol exposure is characterized by low-amplitude LFPs, during which dFB-induced effects are suppressed. Sleep in flies thus appears to involve at least two distinct stages: increased oscillatory activity, particularly during sleep induction, followed by desynchronized or decreased brain activity.

Theoretical-probability evaluation of the fire hazard of coal accumulations

Energy Technology Data Exchange (ETDEWEB)

Sikora, F F

1978-01-01

An evaluation is suggested for the fire hazard of coal accumulations, based on determining the probability of an endogenic fire. This probability is computed by using the statistical characteristics of the temperature distribution of spontaneous heating in large accumulations, and the criteria of Gluzberg's fire hazard that is determined by the coal's physico-chemical properties, oxygen concentration, and the size of the accumulations. 4 references.

A gravimetric method for the measurement of total spontaneous activity in rats.

Science.gov (United States)

Biesiadecki, B J; Brand, P H; Koch, L G; Britton, S L

1999-10-01

Currently available methods for the measurement of spontaneous activity of laboratory animals require expensive, specialized equipment and may not be suitable for use in low light conditions with nocturnal species. We developed a gravimetric method that uses common laboratory equipment to quantify the total spontaneous activity of rats and is suitable for use in the dark. The rat in its home cage is placed on a top-loading electronic balance interfaced to a computer. Movements are recorded by the balance as changes in weight and transmitted to the computer at 10 Hz. Data are analyzed on-line to derive the absolute value of the difference in weight between consecutive samples, and the one-second average of the absolute values is calculated. The averages are written to file for off-line analysis and summed over the desired observation period to provide a measure of total spontaneous activity. The results of in vitro experiments demonstrated that: 1) recorded weight changes were not influenced by position of the weight on the bottom of the cage, 2) values recorded from a series of weight changes were not significantly different from the calculated values, 3) the constantly decreasing force exerted by a swinging pendulum placed on the balance was accurately recorded, 4) the measurement of activity was not influenced by the evaporation of a fluid such as urine, and 5) the method can detect differences in the activity of sleeping and waking rats over a 10-min period, as well as during 4-hr intervals recorded during active (night-time) and inactive (daytime) periods. These results demonstrate that this method provides an inexpensive, accurate, and noninvasive method to quantitate the spontaneous activity of small animals.

THE APPLICATION FOR A PREDICTION OF THE COAL SPONTANEOUS IGNITION – PREDISAM

Directory of Open Access Journals (Sweden)

Vlastimil MONI

2017-04-01

Full Text Available The article follows the research of the project number TA01020351 called “The research of possibilities when predicting steam origin and consequent spontaneous ignition of brown coal fuels” which was researched with the support of the Technological Agency in the Czech Republic in 2011-2014 in the connection with a realized technical research. Therefore, it gives a summary information about the evaluation of the risk degree for the origin of spontaneous ignitions of the brown coal. The presented way of evaluation is based on a numeric expression of a value for MHU criteria – the point load of particular indicators is added together with other results gained from this research project. Then, more information is taken from companies running the dumps of brown coal products – both for suppliers (mining companies and big consumers (power engineering. The complex knowledge about prediction of the origin of the spontaneous ignition enables to make an early response to eliminate a threat of mining fire in open pit mines or on the dumps of coal products. Consequently, it reduces the risk of fire and breakdowns of transportation means DPD, heavy machines and preparation plants. The working injuries are reduced as well – burns by coal in fire or inhalation of gas products from imperfect combustion.

Spontaneous high-gamma band activity reflects functional organization of auditory cortex in the awake macaque.

Science.gov (United States)

Fukushima, Makoto; Saunders, Richard C; Leopold, David A; Mishkin, Mortimer; Averbeck, Bruno B

2012-06-07

In the absence of sensory stimuli, spontaneous activity in the brain has been shown to exhibit organization at multiple spatiotemporal scales. In the macaque auditory cortex, responses to acoustic stimuli are tonotopically organized within multiple, adjacent frequency maps aligned in a caudorostral direction on the supratemporal plane (STP) of the lateral sulcus. Here, we used chronic microelectrocorticography to investigate the correspondence between sensory maps and spontaneous neural fluctuations in the auditory cortex. We first mapped tonotopic organization across 96 electrodes spanning approximately two centimeters along the primary and higher auditory cortex. In separate sessions, we then observed that spontaneous activity at the same sites exhibited spatial covariation that reflected the tonotopic map of the STP. This observation demonstrates a close relationship between functional organization and spontaneous neural activity in the sensory cortex of the awake monkey. Copyright © 2012 Elsevier Inc. All rights reserved.

[Cellular mechanism of the generation of spontaneous activity in gastric muscle].

Science.gov (United States)

Nakamura, Eri; Kito, Yoshihiko; Fukuta, Hiroyasu; Yanai, Yoshimasa; Hashitani, Hikaru; Yamamoto, Yoshimichi; Suzuki, Hikaru

2004-03-01

In gastric smooth muscles, interstitial cells of Cajal (ICC) might be the pacemaker cells of spontaneous activities since ICC are rich in mitochondria and are connected with smooth muscle cells via gap junctions. Several types of ICC are distributed widely in the stomach wall. A group of ICC distributed in the myenteric layer (ICC-MY) were the pacemaker cells of gastrointestinal smooth muscles. Pacemaker potentials were generated in ICC-MY, and the potentials were conducted to circular smooth muscles to trigger slow waves and also conducted to longitudinal muscles to form follower potentials. In circular muscle preparations, interstitial cells distributed within muscle bundles (ICC-IM) produced unitary potentials, which were conducted to circular muscles to form slow potentials by summation. In mutant mice lacking inositol trisphosphate (IP(3)) receptor, slow waves were absent in gastric smooth muscles. The generation of spontaneous activity was impaired by the inhibition of Ca(2+)-release from internal stores through IP(3) receptors, inhibition of mitochondrial Ca(2+)-handling with proton pump inhibitors, and inhibition of ATP-sensitive K(+)-channels at the mitochondrial inner membrane. These results suggested that mitochondrial Ca(2+)-handling causes the generation of spontaneous activity in pacemaker cells. Possible involvement of protein kinase C (PKC) in the Ca(2+) signaling system was also suggested.

Efffects of vigabatrin on spontaneous locomotor activity of rats

NARCIS (Netherlands)

Bouwman, B.M.; Rijn, C.M. van; Willems-van Bree, P.C.M.; Coenen, A.M.L.

2003-01-01

Effects of vigibatrin (saline, 125, 250, or 500 mg/kg i.p.) on spontaneous locomotor activity in Wistar rats were investigated. There was a dose dependent decrease in amount of locomotion for doses up to 250 mg/kg. This decrease was measurable 2-4 hours after injection and still became more

Endosulfan induces changes in spontaneous swimming activity and acetylcholinesterase activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes)

International Nuclear Information System (INIS)

Ballesteros, M.L.; Durando, P.E.; Nores, M.L.; Diaz, M.P.; Bistoni, M.A.; Wunderlin, D.A.

2009-01-01

We assessed changes in spontaneous swimming activity and acetylcholinesterase (AchE) activity of Jenynsia multidentata exposed to Endosulfan (EDS). Females of J. multidentata were exposed to 0.072 and 1.4 μg L -1 EDS. Average speed and movement percentage were recorded during 48 h. We also exposed females to EDS at five concentrations between 0.072 and 1.4 μg L -1 during 24 h, and measured the AchE activity in brain and muscle. At 0.072 μg L -1 EDS swimming motility decreased relative to the control group after 45 h, while at 1.4 μg L -1 EDS swimming motility decreased after 24 h. AchE activity significantly decreased in muscle when J. multidentata were exposed to EDS above 0.072 μg L -1 , while no significant changes were observed in brain. Thus, changes in swimming activity and AchE activity in muscle are good biomarkers of exposure to EDS in J. multidentata. - This work reports changes observed in spontaneous swimming activity and AchE activity of Jenynsia multidentata exposed to sublethal concentrations of Endosulfan.

Endosulfan induces changes in spontaneous swimming activity and acetylcholinesterase activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes)

Energy Technology Data Exchange (ETDEWEB)

Ballesteros, M.L. [Facultad de Ciencias Exactas, Fisicas y Naturales, Catedra Diversidad Animal II, Universidad Nacional de Cordoba, Av. Velez Sarsfield 299, 5000 Cordoba (Argentina); Durando, P.E. [Facultad de Ciencias Exactas, Fisicas y Naturales, Departamento de Biologia, Catedra de Fisiologia Animal, Universidad Nacional de San Juan, Complejo ' Islas Malvinas' , Av. Jose I. de la Roza y Meglioli, Rivadavia, San Juan (Argentina); Nores, M.L. [Facultad de Ciencias Medicas, Universidad Nacional de Cordoba-CONICET, Ciudad Universitaria, Cordoba (Argentina); Diaz, M.P. [Facultad de Ciencias Medicas, Catedra de Estadistica y Bioestadistica, Escuela de Nutricion, Universidad Nacional de Cordoba, Pabellon Chile, Ciudad Universitaria, 5000 Cordoba (Argentina); Bistoni, M.A., E-mail: mbistoni@com.uncor.ed [Facultad de Ciencias Exactas, Fisicas y Naturales, Catedra Diversidad Animal II, Universidad Nacional de Cordoba, Av. Velez Sarsfield 299, 5000 Cordoba (Argentina); Wunderlin, D.A. [Facultad de Ciencias Quimicas, Dto. Bioquimica Clinica-CIBICI, Universidad Nacional de Cordoba-CONICET, Haya de la Torre esq. Medina Allende, Ciudad Universitaria, 5000 Cordoba (Argentina)

2009-05-15

We assessed changes in spontaneous swimming activity and acetylcholinesterase (AchE) activity of Jenynsia multidentata exposed to Endosulfan (EDS). Females of J. multidentata were exposed to 0.072 and 1.4 mug L{sup -1} EDS. Average speed and movement percentage were recorded during 48 h. We also exposed females to EDS at five concentrations between 0.072 and 1.4 mug L{sup -1} during 24 h, and measured the AchE activity in brain and muscle. At 0.072 mug L{sup -1} EDS swimming motility decreased relative to the control group after 45 h, while at 1.4 mug L{sup -1} EDS swimming motility decreased after 24 h. AchE activity significantly decreased in muscle when J. multidentata were exposed to EDS above 0.072 mug L{sup -1}, while no significant changes were observed in brain. Thus, changes in swimming activity and AchE activity in muscle are good biomarkers of exposure to EDS in J. multidentata. - This work reports changes observed in spontaneous swimming activity and AchE activity of Jenynsia multidentata exposed to sublethal concentrations of Endosulfan.

Burns resulting from spontaneous combustion of electronic cigarettes: a case series

OpenAIRE

Sheckter, Clifford; Chattopadhyay, Arhana; Paro, John; Karanas, Yvonne

2016-01-01

Background Electronic cigarette (e-cigarette) sales have grown rapidly in recent years, coinciding with a public perception that they are a safer alternative to traditional cigarettes. However, there have been numerous media reports of fires associated with e-cigarette spontaneous combustion. Case Presentation Three severe burns caused by spontaneous combustion of e-cigarettes within a 6-month period were treated at the Santa Clara Valley Medical Center Burn Unit. Patients sustained partial a...

Contrasting spatial patterns in active-fire and fire-suppressed Mediterranean climate old-growth mixed conifer forests.

Science.gov (United States)

Fry, Danny L; Stephens, Scott L; Collins, Brandon M; North, Malcolm P; Franco-Vizcaíno, Ernesto; Gill, Samantha J

2014-01-01

In Mediterranean environments in western North America, historic fire regimes in frequent-fire conifer forests are highly variable both temporally and spatially. This complexity influenced forest structure and spatial patterns, but some of this diversity has been lost due to anthropogenic disruption of ecosystem processes, including fire. Information from reference forest sites can help management efforts to restore forests conditions that may be more resilient to future changes in disturbance regimes and climate. In this study, we characterize tree spatial patterns using four-ha stem maps from four old-growth, Jeffrey pine-mixed conifer forests, two with active-fire regimes in northwestern Mexico and two that experienced fire exclusion in the southern Sierra Nevada. Most of the trees were in patches, averaging six to 11 trees per patch at 0.007 to 0.014 ha(-1), and occupied 27-46% of the study areas. Average canopy gap sizes (0.04 ha) covering 11-20% of the area were not significantly different among sites. The putative main effects of fire exclusion were higher densities of single trees in smaller size classes, larger proportion of trees (≥ 56%) in large patches (≥ 10 trees), and decreases in spatial complexity. While a homogenization of forest structure has been a typical result from fire exclusion, some similarities in patch, single tree, and gap attributes were maintained at these sites. These within-stand descriptions provide spatially relevant benchmarks from which to manage for structural heterogeneity in frequent-fire forest types.

Quantitative comparison of fire danger index performance using fire activity

CSIR Research Space (South Africa)

Steenkamp, KC

2012-07-01

Full Text Available parameters such as flame length or rate of spread can be physically measured or modeled. Fire danger indices are not designed to describe the characteristics of a fire but rather the potential of a fire taking place in an area of interest [5]. Several...

Changes in spontaneous brain activity in early Parkinson's disease.

Science.gov (United States)

Yang, Hong; Zhou, Xiaohong Joe; Zhang, Min-Ming; Zheng, Xu-Ning; Zhao, Yi-Lei; Wang, Jue

2013-08-09

Resting state brain activity can provide valuable insights into the pathophysiology of Parkinson's disease (PD). The purpose of the present study was (a) to investigate abnormal spontaneous neuronal activity in early PD patients using resting-state functional MRI (fMRI) with a regional homogeneity (ReHo) method and (b) to demonstrate the potential of using changes in abnormal spontaneous neuronal activity for monitoring the progression of PD during its early stages. Seventeen early PD patients were assessed with the Unified Parkinson's Disease Rating Scale (UPDRS), the Hoehn and Yahr disability scale and the Mini-mental State Examination (MMSE) were compared with seventeen gender- and age-matched healthy controls. All subjects underwent MRI scans using a 1.5T General Electric Signa Excite II scanner. The MRI scan protocol included whole-brain volumetric imaging using a 3D inversion recovery prepared (IR-Prep) fast spoiled gradient-echo pulse sequence and 2D multi-slice (22 axial slices covering the whole brain) resting-state fMRI using an echo planar imaging (EPI) sequence. Images were analyzed in SPM5 together with a ReHo algorithm using the in-house software program REST. A corrected threshold of pbrain regions, including the left cerebellum, left parietal lobe, right middle temporal lobe, right sub-thalamic nucleus areas, right superior frontal gyrus, middle frontal gyrus (MFG), right inferior parietal lobe (IPL), right precuneus lobe, left MFG and left IPL. Additionally, significantly reduced ReHo was also observed in the early PD patients in the following brain regions: the left putamen, left inferior frontal gyrus, right hippocampus, right anterior cingulum, and bilateral lingual gyrus. Moreover, in PD patients, ReHo in the left putamen was negatively correlated with the UPDRS scores (r=-0.69). These results indicate that the abnormal resting state spontaneous brain activity associated with patients with early PD can be revealed by Reho analysis. Copyright �

Contrasting spatial patterns in active-fire and fire-suppressed Mediterranean climate old-growth mixed conifer forests.

Directory of Open Access Journals (Sweden)

Danny L Fry

Full Text Available In Mediterranean environments in western North America, historic fire regimes in frequent-fire conifer forests are highly variable both temporally and spatially. This complexity influenced forest structure and spatial patterns, but some of this diversity has been lost due to anthropogenic disruption of ecosystem processes, including fire. Information from reference forest sites can help management efforts to restore forests conditions that may be more resilient to future changes in disturbance regimes and climate. In this study, we characterize tree spatial patterns using four-ha stem maps from four old-growth, Jeffrey pine-mixed conifer forests, two with active-fire regimes in northwestern Mexico and two that experienced fire exclusion in the southern Sierra Nevada. Most of the trees were in patches, averaging six to 11 trees per patch at 0.007 to 0.014 ha(-1, and occupied 27-46% of the study areas. Average canopy gap sizes (0.04 ha covering 11-20% of the area were not significantly different among sites. The putative main effects of fire exclusion were higher densities of single trees in smaller size classes, larger proportion of trees (≥ 56% in large patches (≥ 10 trees, and decreases in spatial complexity. While a homogenization of forest structure has been a typical result from fire exclusion, some similarities in patch, single tree, and gap attributes were maintained at these sites. These within-stand descriptions provide spatially relevant benchmarks from which to manage for structural heterogeneity in frequent-fire forest types.

Dopamine Attenuates Ketamine-Induced Neuronal Apoptosis in the Developing Rat Retina Independent of Early Synchronized Spontaneous Network Activity.

Science.gov (United States)

Dong, Jing; Gao, Lingqi; Han, Junde; Zhang, Junjie; Zheng, Jijian

2017-07-01

Deprivation of spontaneous rhythmic electrical activity in early development by anesthesia administration, among other interventions, induces neuronal apoptosis. However, it is unclear whether enhancement of neuronal electrical activity attenuates neuronal apoptosis in either normal development or after anesthesia exposure. The present study investigated the effects of dopamine, an enhancer of spontaneous rhythmic electrical activity, on ketamine-induced neuronal apoptosis in the developing rat retina. TUNEL and immunohistochemical assays indicated that ketamine time- and dose-dependently aggravated physiological and ketamine-induced apoptosis and inhibited early-synchronized spontaneous network activity. Dopamine administration reversed ketamine-induced neuronal apoptosis, but did not reverse the inhibitory effects of ketamine on early synchronized spontaneous network activity despite enhancing it in controls. Blockade of D1, D2, and A2A receptors and inhibition of cAMP/PKA signaling partially antagonized the protective effect of dopamine against ketamine-induced apoptosis. Together, these data indicate that dopamine attenuates ketamine-induced neuronal apoptosis in the developing rat retina by activating the D1, D2, and A2A receptors, and upregulating cAMP/PKA signaling, rather than through modulation of early synchronized spontaneous network activity.

5 CFR 551.541 - Employees engaged in fire protection activities or law enforcement activities.

Science.gov (United States)

2010-01-01

... activities or law enforcement activities. 551.541 Section 551.541 Administrative Personnel OFFICE OF... activities or law enforcement activities. (a) An employee engaged in fire protection activities or law enforcement activities (as described in §§ 551.215 and 551.216, respectively) who receives compensation for...

Fire protection

International Nuclear Information System (INIS)

Janetzky, E.

1980-01-01

Safety and fire prevention measurements have to be treated like the activities developing, planning, construction and erection. Therefore it is necessary that these measurements have to be integrated into the activities mentioned above at an early stage in order to guarantee their effectiveness. With regard to fire accidents the statistics of the insurance companies concerned show that the damage caused increased in the last years mainly due to high concentration of material. Organization of fire prevention and fire fighting, reasons of fire break out, characteristics and behaviour of fire, smoke and fire detection, smoke and heat venting, fire extinguishers (portable and stationary), construction material in presence of fire, respiratory protection etc. will be discussed. (orig./RW)

Endogenous sequential cortical activity evoked by visual stimuli.

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Carrillo-Reid, Luis; Miller, Jae-Eun Kang; Hamm, Jordan P; Jackson, Jesse; Yuste, Rafael

2015-06-10

Although the functional properties of individual neurons in primary visual cortex have been studied intensely, little is known about how neuronal groups could encode changing visual stimuli using temporal activity patterns. To explore this, we used in vivo two-photon calcium imaging to record the activity of neuronal populations in primary visual cortex of awake mice in the presence and absence of visual stimulation. Multidimensional analysis of the network activity allowed us to identify neuronal ensembles defined as groups of cells firing in synchrony. These synchronous groups of neurons were themselves activated in sequential temporal patterns, which repeated at much higher proportions than chance and were triggered by specific visual stimuli such as natural visual scenes. Interestingly, sequential patterns were also present in recordings of spontaneous activity without any sensory stimulation and were accompanied by precise firing sequences at the single-cell level. Moreover, intrinsic dynamics could be used to predict the occurrence of future neuronal ensembles. Our data demonstrate that visual stimuli recruit similar sequential patterns to the ones observed spontaneously, consistent with the hypothesis that already existing Hebbian cell assemblies firing in predefined temporal sequences could be the microcircuit substrate that encodes visual percepts changing in time. Copyright © 2015 Carrillo-Reid et al.

Browns Ferry fire

International Nuclear Information System (INIS)

Harkleroad, J.R.

1983-01-01

A synopsis of the March 22, 1975 fire at Browns Ferry Nuclear Plant is discussed. Emphasis is placed on events prior to and during the fire. How the fire started, fire fighting activities, fire and smoke development, and restoration activities are discussed

Human presence diminishes the importance of climate in driving fire activity across the United States

Science.gov (United States)

Syphard, Alexandra D.; Keeley, Jon E.; Pfaff, Anne Hopkins; Ferschweiler, Ken

2017-01-01

Growing human and ecological costs due to increasing wildfire are an urgent concern in policy and management, particularly given projections of worsening fire conditions under climate change. Thus, understanding the relationship between climatic variation and fire activity is a critically important scientific question. Different factors limit fire behavior in different places and times, but most fire-climate analyses are conducted across broad spatial extents that mask geographical variation. This could result in overly broad or inappropriate management and policy decisions that neglect to account for regionally specific or other important factors driving fire activity. We developed statistical models relating seasonal temperature and precipitation variables to historical annual fire activity for 37 different regions across the continental United States and asked whether and how fire-climate relationships vary geographically, and why climate is more important in some regions than in others. Climatic variation played a significant role in explaining annual fire activity in some regions, but the relative importance of seasonal temperature or precipitation, in addition to the overall importance of climate, varied substantially depending on geographical context. Human presence was the primary reason that climate explained less fire activity in some regions than in others. That is, where human presence was more prominent, climate was less important. This means that humans may not only influence fire regimes but their presence can actually override, or swamp out, the effect of climate. Thus, geographical context as well as human influence should be considered alongside climate in national wildfire policy and management.

Noise focusing and the emergence of coherent activity in neuronal cultures

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Orlandi, Javier G.; Soriano, Jordi; Alvarez-Lacalle, Enrique; Teller, Sara; Casademunt, Jaume

2013-09-01

At early stages of development, neuronal cultures in vitro spontaneously reach a coherent state of collective firing in a pattern of nearly periodic global bursts. Although understanding the spontaneous activity of neuronal networks is of chief importance in neuroscience, the origin and nature of that pulsation has remained elusive. By combining high-resolution calcium imaging with modelling in silico, we show that this behaviour is controlled by the propagation of waves that nucleate randomly in a set of points that is specific to each culture and is selected by a non-trivial interplay between dynamics and topology. The phenomenon is explained by the noise focusing effect--a strong spatio-temporal localization of the noise dynamics that originates in the complex structure of avalanches of spontaneous activity. Results are relevant to neuronal tissues and to complex networks with integrate-and-fire dynamics and metric correlations, for instance, in rumour spreading on social networks.

Aqueous clay suspensions stabilized by alginate fluid gels for coal spontaneous combustion prevention and control.

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Qin, Botao; Ma, Dong; Li, Fanglei; Li, Yong

2017-11-01

We have developed aqueous clay suspensions stabilized by alginate fluid gels (AFG) for coal spontaneous combustion prevention and control. Specially, this study aimed to characterize the effect of AFG on the microstructure, static and dynamic stability, and coal fire inhibition performances of the prepared AFG-stabilized clay suspensions. Compared with aqueous clay suspensions, the AFG-stabilized clay suspensions manifest high static and dynamic stability, which can be ascribed to the formation of a robust three-dimensional gel network by AFG. The coal acceleration oxidation experimental results show that the prepared AFG-stabilized clay suspensions can improve the coal thermal stability and effectively inhibit the coal spontaneous oxidation process by increasing crossing point temperature (CPT) and reducing CO emission. The prepared low-cost and nontoxic AFG-stabilized clay suspensions, exhibiting excellent coal fire extinguishing performances, indicate great application potentials in coal spontaneous combustion prevention and control.

Modifications of spontaneous oculomotor activity in microgravitational conditions

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Kornilova, L. N.; Goncharenko, A. M.; Polyakov, V. V.; Grigorova, V.; Manev, A.

Investigations on spontaneous oculomotor activity were carried out prior to and after (five cosmonauts) and during space flight (two cosmonauts) on the 3rd, 5th and 164th days of the space flight. Recording of oculomotor activity was carried out by electrooculography on automated data acquisition and processing system "Zora" based on personal computers. During the space flight and after it all the cosmonauts with the eyes closed or open and dark-goggled showed an essential increase of the movements' amplitude when removing the eyes into the extreme positions especially in a vertical direction, occurrence of correcting saccadic movements (or nystagmus), an increase in time of fixing reactions.

Orexin-A increases the firing activity of hippocampal CA1 neurons through orexin-1 receptors.

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Chen, Xin-Yi; Chen, Lei; Du, Yi-Feng

2017-07-01

Orexins including two peptides, orexin-A and orexin-B, are produced in the posterior lateral hypothalamus. Much evidence has indicated that central orexinergic systems play numerous functions including energy metabolism, feeding behavior, sleep/wakefulness, and neuroendocrine and sympathetic activation. Morphological studies have shown that the hippocampal CA1 regions receive orexinergic innervation originating from the hypothalamus. Positive orexin-1 (OX 1 ) receptors are detected in the CA1 regions. Previous behavioral studies have shown that microinjection of OX 1 receptor antagonist into the hippocampus impairs acquisition and consolidation of spatial memory. However, up to now, little has been known about the direct electrophysiological effects of orexin-A on hippocampal CA1 neurons. Employing multibarrel single-unit extracellular recordings, the present study showed that micropressure administration of orexin-A significantly increased the spontaneous firing rate from 2.96 ± 0.85 to 8.45 ± 1.86 Hz (P neurons in male rats. Furthermore, application of the specific OX 1 receptor antagonist SB-334867 alone significantly decreased the firing rate from 4.02 ± 1.08 to 2.11 ± 0.58 Hz in 7 out of the 17 neurons (P neurons. Coapplication of SB-334867 completely blocked orexin-A-induced excitation of hippocampal CA1 neurons. The PLC pathway may be involved in activation of OX 1 receptor-induced excitation of CA1 neurons. Taken together, the present study's results suggest that orexin-A produces excitatory effects on hippocampal neurons via OX 1 receptors. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography.

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2005-06-01

Full Text Available BACKGROUND: The neurophysiological mechanisms underlying tinnitus perception are not well understood. Surprisingly, there have been no group studies comparing abnormalities in ongoing, spontaneous neuronal activity in individuals with and without tinnitus perception. METHODS AND FINDINGS: Here, we show that the spontaneous neuronal activity of a group of individuals with tinnitus (n = 17 is characterised by a marked reduction in alpha (8-12 Hz power together with an enhancement in delta (1.5-4 Hz as compared to a normal hearing control group (n = 16. This pattern was especially pronounced for temporal regions. Moreover, correlations with tinnitus-related distress revealed strong associations with this abnormal spontaneous activity pattern, particularly in right temporal and left frontal areas. Overall, effects were stronger for the alpha than for the delta frequency band. A data stream of 5 min, recorded with a whole-head neuromagnetometer under a resting condition, was sufficient to extract the marked differences. CONCLUSIONS: Despite some limitations, there are arguments that the regional pattern of abnormal spontaneous activity we found could reflect a tinnitus-related cortical network. This finding, which suggests that a neurofeedback approach could reduce the adverse effects of this disturbing condition, could have important implications for the treatment of tinnitus.

Recruitment of Perisomatic Inhibition during Spontaneous Hippocampal Activity In Vitro.

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Anna Beyeler

Full Text Available It was recently shown that perisomatic GABAergic inhibitory postsynaptic potentials (IPSPs originating from basket and chandelier cells can be recorded as population IPSPs from the hippocampal pyramidal layer using extracellular electrodes (eIPSPs. Taking advantage of this approach, we have investigated the recruitment of perisomatic inhibition during spontaneous hippocampal activity in vitro. Combining intracellular and extracellular recordings from pyramidal cells and interneurons, we confirm that inhibitory signals generated by basket cells can be recorded extracellularly, but our results suggest that, during spontaneous activity, eIPSPs are mostly confined to the CA3 rather than CA1 region. CA3 eIPSPs produced the powerful time-locked inhibition of multi-unit activity expected from perisomatic inhibition. Analysis of the temporal dynamics of spike discharges relative to eIPSPs suggests significant but moderate recruitment of excitatory and inhibitory neurons within the CA3 network on a 10 ms time scale, within which neurons recruit each other through recurrent collaterals and trigger powerful feedback inhibition. Such quantified parameters of neuronal interactions in the hippocampal network may serve as a basis for future characterisation of pathological conditions potentially affecting the interactions between excitation and inhibition in this circuit.

Where's the Noise? Key Features of Spontaneous Activity and Neural Variability Arise through Learning in a Deterministic Network.

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Christoph Hartmann

2015-12-01

Full Text Available Even in the absence of sensory stimulation the brain is spontaneously active. This background "noise" seems to be the dominant cause of the notoriously high trial-to-trial variability of neural recordings. Recent experimental observations have extended our knowledge of trial-to-trial variability and spontaneous activity in several directions: 1. Trial-to-trial variability systematically decreases following the onset of a sensory stimulus or the start of a motor act. 2. Spontaneous activity states in sensory cortex outline the region of evoked sensory responses. 3. Across development, spontaneous activity aligns itself with typical evoked activity patterns. 4. The spontaneous brain activity prior to the presentation of an ambiguous stimulus predicts how the stimulus will be interpreted. At present it is unclear how these observations relate to each other and how they arise in cortical circuits. Here we demonstrate that all of these phenomena can be accounted for by a deterministic self-organizing recurrent neural network model (SORN, which learns a predictive model of its sensory environment. The SORN comprises recurrently coupled populations of excitatory and inhibitory threshold units and learns via a combination of spike-timing dependent plasticity (STDP and homeostatic plasticity mechanisms. Similar to balanced network architectures, units in the network show irregular activity and variable responses to inputs. Additionally, however, the SORN exhibits sequence learning abilities matching recent findings from visual cortex and the network's spontaneous activity reproduces the experimental findings mentioned above. Intriguingly, the network's behaviour is reminiscent of sampling-based probabilistic inference, suggesting that correlates of sampling-based inference can develop from the interaction of STDP and homeostasis in deterministic networks. We conclude that key observations on spontaneous brain activity and the variability of neural

Neural network regulation driven by autonomous neural firings

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Cho, Myoung Won

2016-07-01

Biological neurons naturally fire spontaneously due to the existence of a noisy current. Such autonomous firings may provide a driving force for network formation because synaptic connections can be modified due to neural firings. Here, we study the effect of autonomous firings on network formation. For the temporally asymmetric Hebbian learning, bidirectional connections lose their balance easily and become unidirectional ones. Defining the difference between reciprocal connections as new variables, we could express the learning dynamics as if Ising model spins interact with each other in magnetism. We present a theoretical method to estimate the interaction between the new variables in a neural system. We apply the method to some network systems and find some tendencies of autonomous neural network regulation.

Characterizing context-dependent differential firing activity in the hippocampus and entorhinal cortex.

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Prerau, Michael J; Lipton, Paul A; Eichenbaum, Howard B; Eden, Uri T

2014-04-01

The rat hippocampus and entorhinal cortex have been shown to possess neurons with place fields that modulate their firing properties under different behavioral contexts. Such context-dependent changes in neural activity are commonly studied through electrophysiological experiments in which a rat performs a continuous spatial alternation task on a T-maze. Previous research has analyzed context-based differential firing during this task by describing differences in the mean firing activity between left-turn and right-turn experimental trials. In this article, we develop qualitative and quantitative methods to characterize and compare changes in trial-to-trial firing rate variability for sets of experimental contexts. We apply these methods to cells in the CA1 region of hippocampus and in the dorsocaudal medial entorhinal cortex (dcMEC), characterizing the context-dependent differences in spiking activity during spatial alternation. We identify a subset of cells with context-dependent changes in firing rate variability. Additionally, we show that dcMEC populations encode turn direction uniformly throughout the T-maze stem, whereas CA1 populations encode context at major waypoints in the spatial trajectory. Our results suggest scenarios in which individual cells that sparsely provide information on turn direction might combine in the aggregate to produce a robust population encoding. Copyright © 2014 Wiley Periodicals, Inc.

Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels.

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Ma, Weiyuan; Berg, Jim; Yellen, Gary

2007-04-04

A low-carbohydrate ketogenic diet remains one of the most effective (but mysterious) treatments for severe pharmacoresistant epilepsy. We have tested for an acute effect of physiological ketone bodies on neuronal firing rates and excitability, to discover possible therapeutic mechanisms of the ketogenic diet. Physiological concentrations of ketone bodies (beta-hydroxybutyrate or acetoacetate) reduced the spontaneous firing rate of neurons in slices from rat or mouse substantia nigra pars reticulata. This region is thought to act as a "seizure gate," controlling seizure generalization. Consistent with an anticonvulsant role, the ketone body effect is larger for cells that fire more rapidly. The effect of ketone bodies was abolished by eliminating the metabolically sensitive K(ATP) channels pharmacologically or by gene knock-out. We propose that ketone bodies or glycolytic restriction treat epilepsy by augmenting a natural activity-limiting function served by K(ATP) channels in neurons.

Effects of an environmentally-relevant mixture of pyrethroid insecticides on spontaneous activity in primary cortical networks on microelectrode arrays.

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Johnstone, Andrew F M; Strickland, Jenna D; Crofton, Kevin M; Gennings, Chris; Shafer, Timothy J

2017-05-01

Pyrethroid insecticides exert their insecticidal and toxicological effects primarily by disrupting voltage-gated sodium channel (VGSC) function, resulting in altered neuronal excitability. Numerous studies of individual pyrethroids have characterized effects on mammalian VGSC function and neuronal excitability, yet studies examining effects of complex pyrethroid mixtures in mammalian neurons, especially in environmentally relevant mixture ratios, are limited. In the present study, concentration-response functions were characterized for five pyrethroids (permethrin, deltamethrin, cypermethrin, β-cyfluthrin and esfenvalerate) in an in vitro preparation containing cortical neurons and glia. As a metric of neuronal network activity, spontaneous mean network firing rates (MFR) were measured using microelectorde arrays (MEAs). In addition, the effect of a complex and exposure relevant mixture of the five pyrethroids (containing 52% permethrin, 28.8% cypermethrin, 12.9% β-cyfluthrin, 3.4% deltamethrin and 2.7% esfenvalerate) was also measured. Data were modeled to determine whether effects of the pyrethroid mixture were predicted by dose-addition. At concentrations up to 10μM, all compounds except permethrin reduced MFR. Deltamethrin and β-cyfluthrin were the most potent and reduced MFR by as much as 60 and 50%, respectively, while cypermethrin and esfenvalerate were of approximately equal potency and reduced MFR by only ∼20% at the highest concentration. Permethrin caused small (∼24% maximum), concentration-dependent increases in MFR. Effects of the environmentally relevant mixture did not depart from the prediction of dose-addition. These data demonstrate that an environmentally relevant mixture caused dose-additive effects on spontaneous neuronal network activity in vitro, and is consistent with other in vitro and in vivo assessments of pyrethroid mixtures. Published by Elsevier B.V.

The wiring of developing sensory circuits - from patterned spontaneous activity to mechanisms of synaptic plasticity

Directory of Open Access Journals (Sweden)

Alexandra Helen Leighton

2016-09-01

Full Text Available In order to accurately process incoming sensory stimuli, neurons must be organized into functional networks, with both genetic and environmental factors influencing the precise arrangement of connections between cells. Teasing apart the relative contributions of molecular guidance cues, spontaneous activity and visual experience during this maturation is on-going. During development of the sensory system, the first, rough organization of connections is created by molecular factors. These connections are then modulated by the intrinsically generated activity of neurons, even before the senses have become operational. Spontaneous waves of depolarisations sweep across the nervous system, placing them in a prime position to strengthen correct connections and weaken others, shaping synapses into a useful network. A large body of work now supports the idea that, rather than being a mere side-effect of the system, spontaneous activity actually contains information which readies the nervous system so that, as soon as the senses become active, sensory information can be utilized by the animal. An example is the neonatal mouse. As soon as the eyelids first open, neurons in the cortex respond to visual information without the animal having previously encountered structured sensory input (Cang et al., 2005a; Ko et al., 2013; Rochefort et al., 2011; Zhang et al., 2012. In vivo imaging techniques have advanced considerably, allowing observation of the natural activity in the brain of living animals down to the level of the individual synapse. New (optogenetic methods make it possible to subtly modulate the spatio-temporal properties of activity, aiding our understanding of how these characteristics relate to the function of spontaneous activity. Such experiments have had a huge impact on our knowledge by permitting direct testing of ideas about the plasticity mechanisms at play in the intact system, opening up a provocative range of fresh questions. Here, we

Codimension-two bifurcation analysis on firing activities in Chay neuron model

International Nuclear Information System (INIS)

Duan Lixia; Lu Qishao

2006-01-01

Using codimension-two bifurcation analysis in the Chay neuron model, the relationship between the electric activities and the parameters of neurons is revealed. The whole parameter space is divided into two parts, that is, the firing and silence regions of neurons. It is found that the transition sets between firing and silence regions are composed of the Hopf bifurcation curves of equilibrium states and the saddle-node bifurcation curves of limit cycles, with some codimension-two bifurcation points. The transitions from silence to firing in neurons are due to the Hopf bifurcation or the fold limit cycle bifurcation, but the codimension-two singularities lead to complexity in dynamical behaviour of neuronal firing

Codimension-two bifurcation analysis on firing activities in Chay neuron model

Energy Technology Data Exchange (ETDEWEB)

Duan Lixia [School of Science, Beijing University of Aeronautics and Astronautics, Beijing 100083 (China); Lu Qishao [School of Science, Beijing University of Aeronautics and Astronautics, Beijing 100083 (China)]. E-mail: qishaolu@hotmail.com

2006-12-15

Using codimension-two bifurcation analysis in the Chay neuron model, the relationship between the electric activities and the parameters of neurons is revealed. The whole parameter space is divided into two parts, that is, the firing and silence regions of neurons. It is found that the transition sets between firing and silence regions are composed of the Hopf bifurcation curves of equilibrium states and the saddle-node bifurcation curves of limit cycles, with some codimension-two bifurcation points. The transitions from silence to firing in neurons are due to the Hopf bifurcation or the fold limit cycle bifurcation, but the codimension-two singularities lead to complexity in dynamical behaviour of neuronal firing.

Fire activity and severity in the western US vary along proxy gradients representing fuel amount and fuel moisture.

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Sean A Parks

Full Text Available Numerous theoretical and empirical studies have shown that wildfire activity (e.g., area burned at regional to global scales may be limited at the extremes of environmental gradients such as productivity or moisture. Fire activity, however, represents only one component of the fire regime, and no studies to date have characterized fire severity along such gradients. Given the importance of fire severity in dictating ecological response to fire, this is a considerable knowledge gap. For the western US, we quantify relationships between climate and the fire regime by empirically describing both fire activity and severity along two climatic water balance gradients, actual evapotranspiration (AET and water deficit (WD, that can be considered proxies for fuel amount and fuel moisture, respectively. We also concurrently summarize fire activity and severity among ecoregions, providing an empirically based description of the geographic distribution of fire regimes. Our results show that fire activity in the western US increases with fuel amount (represented by AET but has a unimodal (i.e., humped relationship with fuel moisture (represented by WD; fire severity increases with fuel amount and fuel moisture. The explicit links between fire regime components and physical environmental gradients suggest that multivariable statistical models can be generated to produce an empirically based fire regime map for the western US. Such models will potentially enable researchers to anticipate climate-mediated changes in fire recurrence and its impacts based on gridded spatial data representing future climate scenarios.

TETRAMETHRIN AND DDT INHIBIT SPONTANEOUS FIRING IN CORTICAL NEURONAL NETWORKS

Science.gov (United States)

The insecticidal and neurotoxic effects of pyrethroids result from prolonged sodium channel inactivation, which causes alterations in neuronal firing and communication. Previously, we determined the relative potencies of 11 type I and type II pyrethroid insecticides using microel...

Copper is an endogenous modulator of neural circuit spontaneous activity.

Science.gov (United States)

Dodani, Sheel C; Firl, Alana; Chan, Jefferson; Nam, Christine I; Aron, Allegra T; Onak, Carl S; Ramos-Torres, Karla M; Paek, Jaeho; Webster, Corey M; Feller, Marla B; Chang, Christopher J

2014-11-18

For reasons that remain insufficiently understood, the brain requires among the highest levels of metals in the body for normal function. The traditional paradigm for this organ and others is that fluxes of alkali and alkaline earth metals are required for signaling, but transition metals are maintained in static, tightly bound reservoirs for metabolism and protection against oxidative stress. Here we show that copper is an endogenous modulator of spontaneous activity, a property of functional neural circuitry. Using Copper Fluor-3 (CF3), a new fluorescent Cu(+) sensor for one- and two-photon imaging, we show that neurons and neural tissue maintain basal stores of loosely bound copper that can be attenuated by chelation, which define a labile copper pool. Targeted disruption of these labile copper stores by acute chelation or genetic knockdown of the CTR1 (copper transporter 1) copper channel alters the spatiotemporal properties of spontaneous activity in developing hippocampal and retinal circuits. The data identify an essential role for copper neuronal function and suggest broader contributions of this transition metal to cell signaling.

Bi-directional astrocytic regulation of neuronal activity within a network

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Susan Yu Gordleeva

2012-11-01

Full Text Available The concept of a tripartite synapse holds that astrocytes can affect both the pre- and postsynaptic compartments through the Ca2+-dependent release of gliotransmitters. Because astrocytic Ca2+ transients usually last for a few seconds, we assumed that astrocytic regulation of synaptic transmission may also occur on the scale of seconds. Here, we considered the basic physiological functions of tripartite synapses and investigated astrocytic regulation at the level of neural network activity. The firing dynamics of individual neurons in a spontaneous firing network was described by the Hodgkin-Huxley model. The neurons received excitatory synaptic input driven by the Poisson spike train with variable frequency. The mean field concentration of the released neurotransmitter was used to describe the presynaptic dynamics. The amplitudes of the excitatory postsynaptic currents (PSCs obeyed the gamma distribution law. In our model, astrocytes depressed the presynaptic release and enhanced the postsynaptic currents. As a result, low frequency synaptic input was suppressed while high frequency input was amplified. The analysis of the neuron spiking frequency as an indicator of network activity revealed that tripartite synaptic transmission dramatically changed the local network operation compared to bipartite synapses. Specifically, the astrocytes supported homeostatic regulation of the network activity by increasing or decreasing firing of the neurons. Thus, the astrocyte activation may modulate a transition of neural network into bistable regime of activity with two stable firing levels and spontaneous transitions between them.

Characterizing Tropical Forest Cover Loss Using Dense Sentinel-1 Data and Active Fire Alerts

NARCIS (Netherlands)

Reiche, Johannes; Verhoeven, Rob; Verbesselt, Jan; Hamunyela, Eliakim; Wielaard, Niels; Herold, Martin

2018-01-01

Fire use for land management is widespread in natural tropical and plantation forests, causing major environmental and economic damage. Recent studies combining active fire alerts with annual forest-cover loss information identified fire-related forest-cover loss areas well, but do not provide

Peripheral facial nerve lesions induce changes in the firing properties of primary motor cortex layer 5 pyramidal cells.

Science.gov (United States)

Múnera, A; Cuestas, D M; Troncoso, J

2012-10-25

Facial nerve lesions elicit long-lasting changes in vibrissal primary motor cortex (M1) muscular representation in rodents. Reorganization of cortical representation has been attributed to potentiation of preexisting horizontal connections coming from neighboring muscle representation. However, changes in layer 5 pyramidal neuron activity induced by facial nerve lesion have not yet been explored. To do so, the effect of irreversible facial nerve injury on electrophysiological properties of layer 5 pyramidal neurons was characterized. Twenty-four adult male Wistar rats were randomly subjected to two experimental treatments: either surgical transection of mandibular and buccal branches of the facial nerve (n=18) or sham surgery (n=6). Unitary and population activity of vibrissal M1 layer 5 pyramidal neurons recorded in vivo under general anesthesia was compared between sham-operated and facial nerve-injured animals. Injured animals were allowed either one (n=6), three (n=6), or five (n=6) weeks recovery before recording in order to characterize the evolution of changes in electrophysiological activity. As compared to control, facial nerve-injured animals displayed the following sustained and significant changes in spontaneous activity: increased basal firing frequency, decreased spike-associated local field oscillation amplitude, and decreased spontaneous theta burst firing frequency. Significant changes in evoked-activity with whisker pad stimulation included: increased short latency population spike amplitude, decreased long latency population oscillations amplitude and frequency, and decreased peak frequency during evoked single-unit burst firing. Taken together, such changes demonstrate that peripheral facial nerve lesions induce robust and sustained changes of layer 5 pyramidal neurons in vibrissal motor cortex. Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

Altered spontaneous brain activity in patients with hemifacial spasm: a resting-state functional MRI study.

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Ye Tu

Full Text Available Resting-state functional magnetic resonance imaging (fMRI has been used to detect the alterations of spontaneous neuronal activity in various neurological and neuropsychiatric diseases, but rarely in hemifacial spasm (HFS, a nervous system disorder. We used resting-state fMRI with regional homogeneity (ReHo analysis to investigate changes in spontaneous brain activity of patients with HFS and to determine the relationship of these functional changes with clinical features. Thirty patients with HFS and 33 age-, sex-, and education-matched healthy controls were included in this study. Compared with controls, HFS patients had significantly decreased ReHo values in left middle frontal gyrus (MFG, left medial cingulate cortex (MCC, left lingual gyrus, right superior temporal gyrus (STG and right precuneus; and increased ReHo values in left precentral gyrus, anterior cingulate cortex (ACC, right brainstem, and right cerebellum. Furthermore, the mean ReHo value in brainstem showed a positive correlation with the spasm severity (r = 0.404, p = 0.027, and the mean ReHo value in MFG was inversely related with spasm severity in HFS group (r = -0.398, p = 0.028. This study reveals that HFS is associated with abnormal spontaneous brain activity in brain regions most involved in motor control and blinking movement. The disturbances of spontaneous brain activity reflected by ReHo measurements may provide insights into the neurological pathophysiology of HFS.

Spontaneous cortical activity reveals hallmarks of an optimal internal model of the environment.

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Berkes, Pietro; Orbán, Gergo; Lengyel, Máté; Fiser, József

2011-01-07

The brain maintains internal models of its environment to interpret sensory inputs and to prepare actions. Although behavioral studies have demonstrated that these internal models are optimally adapted to the statistics of the environment, the neural underpinning of this adaptation is unknown. Using a Bayesian model of sensory cortical processing, we related stimulus-evoked and spontaneous neural activities to inferences and prior expectations in an internal model and predicted that they should match if the model is statistically optimal. To test this prediction, we analyzed visual cortical activity of awake ferrets during development. Similarity between spontaneous and evoked activities increased with age and was specific to responses evoked by natural scenes. This demonstrates the progressive adaptation of internal models to the statistics of natural stimuli at the neural level.

Resolving vorticity-driven lateral fire spread using the WRF-Fire coupled atmosphere–fire numerical model

OpenAIRE

Simpson, C. C.; Sharples, J. J.; Evans, J. P.

2014-01-01

Fire channelling is a form of dynamic fire behaviour, during which a wildland fire spreads rapidly across a steep lee-facing slope in a direction transverse to the background winds, and is often accompanied by a downwind extension of the active flaming region and extreme pyro-convection. Recent work using the WRF-Fire coupled atmosphere-fire model has demonstrated that fire channelling can be characterised as vorticity-driven lateral fire spread (VDLS). In t...

Intracellular Methamphetamine Prevents the Dopamine-induced Enhancement of Neuronal Firing*

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Saha, Kaustuv; Sambo, Danielle; Richardson, Ben D.; Lin, Landon M.; Butler, Brittany; Villarroel, Laura; Khoshbouei, Habibeh

2014-01-01

The dysregulation of the dopaminergic system is implicated in multiple neurological and neuropsychiatric disorders such as Parkinson disease and drug addiction. The primary target of psychostimulants such as amphetamine and methamphetamine is the dopamine transporter (DAT), the major regulator of extracellular dopamine levels in the brain. However, the behavioral and neurophysiological correlates of methamphetamine and amphetamine administration are unique from one another, thereby suggesting these two compounds impact dopaminergic neurotransmission differentially. We further examined the unique mechanisms by which amphetamine and methamphetamine regulate DAT function and dopamine neurotransmission; in the present study we examined the impact of extracellular and intracellular amphetamine and methamphetamine on the spontaneous firing of cultured midbrain dopaminergic neurons and isolated DAT-mediated current. In dopaminergic neurons the spontaneous firing rate was enhanced by extracellular application of amphetamine > dopamine > methamphetamine and was DAT-dependent. Amphetamine > methamphetamine similarly enhanced DAT-mediated inward current, which was sensitive to isosmotic substitution of Na+ or Cl− ion. Although isosmotic substitution of extracellular Na+ ions blocked amphetamine and methamphetamine-induced DAT-mediated inward current similarly, the removal of extracellular Cl− ions preferentially blocked amphetamine-induced inward current. The intracellular application of methamphetamine, but not amphetamine, prevented the dopamine-induced increase in the spontaneous firing of dopaminergic neurons and the corresponding DAT-mediated inward current. The results reveal a new mechanism for methamphetamine-induced dysregulation of dopaminergic neurons. PMID:24962577

Evaluation of a wearable physiological status monitor during simulated fire fighting activities.

Science.gov (United States)

Smith, Denise L; Haller, Jeannie M; Dolezal, Brett A; Cooper, Christopher B; Fehling, Patricia C

2014-01-01

A physiological status monitor (PSM) has been embedded in a fire-resistant shirt. The purpose of this research study was to examine the ability of the PSM-shirt to accurately detect heart rate (HR) and respiratory rate (RR) when worn under structural fire fighting personal protective equipment (PPE) during the performance of various activities relevant to fire fighting. Eleven healthy, college-aged men completed three activities (walking, searching/crawling, and ascending/descending stairs) that are routinely performed during fire fighting operations while wearing the PSM-shirt under structural fire fighting PPE. Heart rate and RR recorded by the PSM-shirt were compared to criterion values measured concurrently with an ECG and portable metabolic measurement system, respectively. For all activities combined (overall) and for each activity, small differences were found between the PSM-shirt and ECG (mean difference [95% CI]: overall: -0.4 beats/min [-0.8, -0.1]; treadmill: -0.4 beats/min [-0.7, -0.1]; search: -1.7 beats/min [-3.1, -.04]; stairs: 0.4 beats/min [0.04, 0.7]). Standard error of the estimate was 3.5 beats/min for all tasks combined and 1.9, 5.9, and 1.9 beats/min for the treadmill walk, search, and stair ascent/descent, respectively. Correlations between the PSM-shirt and criterion heart rates were high (r = 0.95 to r = 0.99). The mean difference between RR recorded by the PSM-shirt and criterion overall was 1.1 breaths/min (95% CI: -1.9 to -0.4). The standard error of the estimate for RR ranged from 4.2 breaths/min (treadmill) to 8.2 breaths/min (search), with an overall value of 6.2 breaths/min. These findings suggest that the PSM-shirt provides valid measures of HR and useful approximations of RR when worn during fire fighting duties.

Atmospheric conditions associated with extreme fire activity in the Western Mediterranean region.

Science.gov (United States)

Amraoui, Malik; Pereira, Mário G; DaCamara, Carlos C; Calado, Teresa J

2015-08-15

Active fire information provided by TERRA and AQUA instruments on-board sun-synchronous polar MODIS platform is used to describe fire activity in the Western Mediterranean and to identify and characterize the synoptic patterns of several meteorological fields associated with the occurrence of extreme fire activity episodes (EEs). The spatial distribution of the fire pixels during the period of 2003-2012 leads to the identification of two most affected sub-regions, namely the Northern and Western parts of the Iberian Peninsula (NWIP) and Northern Africa (NAFR). The temporal distribution of the fire pixels in these two sub-regions is characterized by: (i) high and non-concurrent inter- and intra-annual variability with maximum values during the summer of 2003 and 2005 in NWIP and 2007 and 2012 in NAFR; and, (ii) high intra-annual variability dominated by a prominent annual cycle with a main peak centred in August in both sub-regions and a less pronounced secondary peak in March only evident in NWIP region. The 34 EEs identified were grouped according to the location, period of occurrence and spatial configuration of the associated synoptic patterns into 3 clusters (NWIP-summer, NWIP-winter and NAFR-summer). Results from the composite analysis reveal similar fire weather conditions (statistically significant positive anomalies of air temperature and negative anomalies of air relative humidity) but associated with different circulation patterns at lower and mid-levels of the atmosphere associated with the occurrence of EEs in each cluster of the Western Mediterranean region. Copyright © 2015 Elsevier B.V. All rights reserved.

Spatiotemporal stability of neonatal rat cardiomyocyte monolayers spontaneous activity is dependent on the culture substrate.

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Jonathan Boudreau-Béland

Full Text Available In native conditions, cardiac cells must continuously comply with diverse stimuli necessitating a perpetual adaptation. Polydimethylsiloxane (PDMS is commonly used in cell culture to study cellular response to changes in the mechanical environment. The aim of this study was to evaluate the impact of using PDMS substrates on the properties of spontaneous activity of cardiomyocyte monolayer cultures. We compared PDMS to the gold standard normally used in culture: a glass substrate. Although mean frequency of spontaneous activity remained unaltered, incidence of reentrant activity was significantly higher in samples cultured on glass compared to PDMS substrates. Higher spatial and temporal instability of the spontaneous rate activation was found when cardiomyocytes were cultured on PDMS, and correlated with decreased connexin-43 and increased CaV3.1 and HCN2 mRNA levels. Compared to cultures on glass, cultures on PDMS were associated with the strongest response to isoproterenol and acetylcholine. These results reveal the importance of carefully selecting the culture substrate for studies involving mechanical stimulation, especially for tissue engineering or pharmacological high-throughput screening of cardiac tissue analog.

Static and dynamic controls on fire activity at moderate spatial and temporal scales in the Alaskan boreal forest

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Barrett, Kirsten; Loboda, Tatiana; McGuire, A. David; Genet, Hélène; Hoy, Elizabeth; Kasischke, Eric

2016-01-01

Wildfire, a dominant disturbance in boreal forests, is highly variable in occurrence and behavior at multiple spatiotemporal scales. New data sets provide more detailed spatial and temporal observations of active fires and the post-burn environment in Alaska. In this study, we employ some of these new data to analyze variations in fire activity by developing three explanatory models to examine the occurrence of (1) seasonal periods of elevated fire activity using the number of MODIS active fire detections data set (MCD14DL) within an 11-day moving window, (2) unburned patches within a burned area using the Monitoring Trends in Burn Severity fire severity product, and (3) short-to-moderate interval (fires using areas of burned area overlap in the Alaska Large Fire Database. Explanatory variables for these three models included dynamic variables that can change over the course of the fire season, such as weather and burn date, as well as static variables that remain constant over a fire season, such as topography, drainage, vegetation cover, and fire history. We found that seasonal periods of high fire activity are associated with both seasonal timing and aggregated weather conditions, as well as the landscape composition of areas that are burning. Important static inputs to the model of seasonal fire activity indicate that when fire weather conditions are suitable, areas that typically resist fire (e.g., deciduous stands) may become more vulnerable to burning and therefore less effective as fire breaks. The occurrence of short-to-moderate interval fires appears to be primarily driven by weather conditions, as these were the only relevant explanatory variables in the model. The unique importance of weather in explaining short-to-moderate interval fires implies that fire return intervals (FRIs) will be sensitive to projected climate changes in the region. Unburned patches occur most often in younger stands, which may be related to a greater deciduous fraction of

Force Protection for Fire Fighters: Warm Zone Operations at Paramilitary Style Active Shooter Incidents in a Multi-Hazard Environment as a Fire Service Core Competency

Science.gov (United States)

2012-03-01

Attacks,” Der Speigel, July 25, 2011, http://www.spiegel.de/international/europe/0,1518,776437,00.html 114 “Profile: Anders Behring Breivik ,” BBC...144 Patrick Donovan, “Puyallup Fire & Rescue’s Response to Active School Shooting Incident,” National Fire Academy (July 2008): 24, 26, 49...Learn Them.” Homeland Security Affairs Journal II, no. 2 (July 2006): 11. Donovan, Patrick . “Puyallup Fire & Rescue’s Response to Active School

Search for spontaneous fission activity in Salton Sea and Atlantis II hot brines

International Nuclear Information System (INIS)

Ter-Akopian, G.M.; Sokol, E.A.; Fam Ngoc Chuong; Ivanov, M.P.; Popeko, G.S.; Molzahn, D.; Lund, T.; Feige, G.; Brandt, R.

1984-01-01

A search for an unknown spontaneously fissioning activity, possibly due to SHE, was carried out with the Dubna 3 He-counter system. In the investigation of Salton Sea samples and Atlantis II samples no such activity could be detected with limits -12 g/g. (orig.)

Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients

DEFF Research Database (Denmark)

Ge, Hong-You; Wang, Ying; Fernandez-de-las-Penas, Cesar

2011-01-01

It has previously been reported that local and referred pain from active myofascial trigger points (MTPs) in the neck and shoulder region contribute to fibromyalgia (FM) pain and that the pain pattern induced from active MTPs can reproduce parts of the spontaneous clinical FM pain pattern....... The current study investigated whether the overall spontaneous FM pain pattern can be reproduced by local and referred pain from active MTPs located in different muscles....

Oscillatory brain activity in spontaneous and induced sleep stages in flies

OpenAIRE

Yap, Melvyn H. W.; Grabowska, Martyna J.; Rohrscheib, Chelsie; Jeans, Rhiannon; Troup, Michael; Paulk, Angelique C.; van Alphen, Bart; Shaw, Paul J.; van Swinderen, Bruno

2017-01-01

Sleep is a dynamic process comprising multiple stages, each associated with distinct electrophysiological properties and potentially serving different functions. While these phenomena are well described in vertebrates, it is unclear if invertebrates have distinct sleep stages. We perform local field potential (LFP) recordings on flies spontaneously sleeping, and compare their brain activity to flies induced to sleep using either genetic activation of sleep-promoting circuitry or the GABAA ago...

Appraisal of Passive and Active Fire Protection Systems in Student’s Accommodation

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Ismail I.

2014-03-01

Full Text Available Fire protection systems are very important systems that must be included in buildings. They have a great significance in reducing or preventing the occurrences of fire. This paper presents an assessment of fire protection systems in student’s accommodation. Student accommodation is a particular type of building that provides shelter for students at University. In addition, it is also supposed to be an attractive environment, conducive to learning, and importantly, safe for occupation. The fire safety of occupants in a building, must be in accordance with the requirements of the building’s code. Therefore, the design of the building must comply with the Uniform Building By-Law (UBBL 1984 of Malaysia, and provide all of the required safety features. This paper describes the findings from investigations of passive and active fire protection systems installed in buildings, based on fire safety requirements, UBBL (1984.

Evaluating Greenhouse Gas Emissions Reporting Systems for Agricultural Waste Burning Using MODIS Active Fires

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Lin, H.; Jin, Y.; Giglio, L.; Foley, J. A.; Randerson, J. T.

2010-12-01

Fires in agricultural ecosystems emit greenhouse gases and aerosols that influence climate on multiple spatial and temporal scales. Annex 1 countries of the United Nations Framework Convention on Climate Change (UNFCCC), many of which ratified the Kyoto Protocol, are required to report emissions of CO2, CH4 and N2O from these fires annually. We evaluated several aspects of this reporting system, including the optimality of the crops targeted by the UNFCCC globally and within Annex 1 countries and the consistency of emissions reporting among countries. We also evaluated the success of the individual countries in capturing interannual variability and long-term trends in agricultural fire activity. We combined global crop maps with Terra and Aqua Moderate Resolution Imaging Spectroradiometer (MODIS) active fire detections. At a global scale, we recommend adding ground nuts, cocoa, cotton and oil palm, and removing potato, oats, pulse other and rye from the UNFCCC list of 14 crops. This leads to an overall increase of 6% of the active fires covered by the reporting system. Optimization led to a different recommended list for Annex 1 countries. Extending emissions reporting to all Annex 1 countries (from the current set of 19 countries) would increase the efficacy of the reporting system from 10% to 20%, and further including several non-Annex 1 countries (Argentina, Brazil, China, India, Indonesia, Thailand, Kazakhstan, Mexico and Nigeria) would capture over 58% of active fires in croplands worldwide. Analyses of interannual trends from the U.S. and Australia showed the importance of both intensity of fire use and crop production in controlling year-to-year variations in agricultural fire emissions. Remote sensing provides an efficient tool for an independent assessment of current UNFCCC emissions reporting system; and, if combined with census data, field experiments and expert opinion, has the potential for improving the robustness of the next generation inventory

Adsorber fires

International Nuclear Information System (INIS)

Holmes, W.

1987-01-01

The following conclusions are offered with respect to activated charcoal filter systems in nuclear power plants: (1) The use of activated charcoal in nuclear facilities presents a potential for deep-seated fires. (2) The defense-in-depth approach to nuclear fire safety requires that if an ignition should occur, fires must be detected quickly and subsequently suppressed. (3) Deep-seated fires in charcoal beds are difficult to extinguish. (4) Automatic water sprays can be used to extinguish fires rapidly and reliably when properly introduced into the burning medium. The second part of the conclusions offered are more like challenges: (1) The problem associated with inadvertent actuations of fire protection systems is not a major one, and it can be reduced further by proper design review, installation, testing, and maintenance. Eliminating automatic fire extinguishing systems for the protection of charcoal adsorbers is not justified. (2) Removal of automatic fire protection systems due to fear of inadvertent fire protection system operation is a case of treating the effect rather than the cause. On the other hand, properly maintaining automatic fire protection systems will preserve the risk of fire loss at acceptable levels while at the same time reducing the risk of damage presented by inadvertent operation of fire protection systems

GABAB-receptor activation alters the firing pattern of dopamine neurons in the rat substantia nigra.

Science.gov (United States)

Engberg, G; Kling-Petersen, T; Nissbrandt, H

1993-11-01

Previous electrophysiological experiments have emphasized the importance of the firing pattern for the functioning of midbrain dopamine (DA) neurons. In this regard, excitatory amino acid receptors appear to constitute an important modulatory control mechanism. In the present study, extracellular recording techniques were used to investigate the significance of GABAB-receptor activation for the firing properties of DA neurons in the substantia nigra (SN) in the rat. Intravenous administration of the GABAB-receptor agonist baclofen (1-16 mg/kg) was associated with a dose-dependent regularization of the firing pattern, concomitant with a reduction in burst firing. At higher doses (16-32 mg/kg), the firing rate of the DA neurons was dose-dependently decreased. Also, microiontophoretic application of baclofen regularized the firing pattern of nigral DA neurons, including a reduction of burst firing. Both the regularization of the firing pattern and inhibition of firing rate produced by systemic baclofen administration was antagonized by the GABAB-receptor antagonist CGP 35348 (200 mg/kg, i.v.). The GABAA-receptor agonist muscimol produced effects on the firing properties of DA neurons that were opposite to those observed following baclofen, i.e., an increase in firing rate accompanied by a decreased regularity. The NMDA receptor antagonist MK 801 (0.4-3.2 mg/kg, i.v.) produced a moderate, dose-dependent increase in the firing rate of the nigral DA neurons as well as a slightly regularized firing pattern. Pretreatment with MK 801 (3.2 mg/kg, i.v., 3-10 min) did neither promote nor prevent the regularization of the firing pattern or inhibition of firing rate on the nigral DA neurons produced by baclofen. The present results clearly show that GABAB-receptors can alter the firing pattern of nigral DA neurons, hereby counterbalancing the previously described ability of glutamate to induce burst firing activity on these neurons.

Endo- and exocytic rate constants for spontaneous and protein kinase C-activated T cell receptor cycling

DEFF Research Database (Denmark)

Menné, Charlotte; Møller Sørensen, Tine; Siersma, Volkert

2002-01-01

To determine the rate constants of spontaneous and activated TCR cycling, we examined TCR endo- and exocytosis in the human T cell line Jurkat by three different methods. Using a simple kinetic model for TCR cycling and non-linear regression analyses, we found that the spontaneous endocytic rate...... constant of the TCR was low (approximately 0.012 min(-1)) whereas the spontaneous exocytic rate constant was similar to that of other cycling receptors (approximately 0.055 min(-1)). Following protein kinase C activation (PKC) the endocytic rate constant was increased tenfold (to approximately 0.128 min(-1......)) whereas the exocytic rate constant was unaffected. Thus, the TCR becomes a rapidly cycling receptor with kinetics similar to classical cycling receptors subsequent to PKC activation. This results in a reduction of the half-life of cell surface expressed TCR from approximately 58 to 6 min and allows rapid...

Nitric oxide signaling pathways involved in the inhibition of spontaneous activity in the guinea pig prostate.

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Dey, Anupa; Lang, Richard J; Exintaris, Betty

2012-06-01

We investigated nitric oxide mediated inhibition of spontaneous activity recorded in young and aging guinea pig prostates. Conventional intracellular microelectrode and tension recording techniques were used. The nitric oxide donor sodium nitroprusside (10 μM) abolished spontaneous contractions and slow wave activity in 5 young and 5 aging prostates. Upon adding the nitric oxide synthase inhibitor L-NAME (10 μM) the frequency of spontaneous contractile and electrical activity was significantly increased in each age group. This increase was significantly larger in 4 to 8 preparations of younger vs aging prostates (about 40% to 50% vs about 10% to 20%, 2-way ANOVA pguinea pig prostates (Student paired t test pproduction. This may further explain the increase in prostatic smooth muscle tone observed in age related prostate specific conditions, such as benign prostatic hyperplasia. Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Triggered Firing and Atrial Fibrillation in Transgenic Mice With Selective Atrial Fibrosis Induced by Overexpression of TGF-β1

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Choi, Eue-Keun; Chang, Po-Cheng; Lee, Young-Soo; Lin, Shien-Fong; Zhu, Wuqiang; Maruyama, Mitsunori; Fishbein, Michael C.; Chen, Zhenhui; der Lohe, Michael Rubart-von; Field, Loren J.; Chen, Peng-Sheng

2013-01-01

Background Calcium transient triggered firing (CTTF) is induced by large intracellular calcium (Cai) transient and short action potential duration (APD). We hypothesized that CTTF underlies the mechanisms of early afterdepolarization (EAD) and spontaneous recurrent atrial fibrillation (AF) in transgenic (Tx) mice with overexpression of transforming growth factor β1 (TGF-β1). Methods and Results MHC-TGFcys33ser Tx mice develop atrial fibrosis because of elevated levels of TGF-β1. We studied membrane potential and Cai transients of isolated superfused atria from Tx and wild-type (Wt) littermates. Short APD and persistently elevated Cai transients promoted spontaneous repetitive EADs, triggered activity and spontaneous AF after cessation of burst pacing in Tx but not Wt atria (39% vs. 0%, P=0.008). We were able to map optically 4 episodes of spontaneous AF re-initiation. All first and second beats of spontaneous AF originated from the right atrium (4/4, 100%), which is more severely fibrotic than the left atrium. Ryanodine and thapsigargin inhibited spontaneous re-initiation of AF in all 7 Tx atria tested. Western blotting showed no significant changes of calsequestrin or sarco/endoplasmic reticulum Ca2+-ATPase 2a. Conclusions Spontaneous AF may occur in the Tx atrium because of CTTF, characterized by APD shortening, prolonged Cai transient, EAD and triggered activity. Inhibition of Ca2+ release from the sarcoplasmic reticulum suppressed spontaneous AF. Our results indicate that CTTF is an important arrhythmogenic mechanism in TGF-β1 Tx atria. PMID:22447020

Neurofeedback Tunes Scale-Free Dynamics in Spontaneous Brain Activity.

Science.gov (United States)

Ros, T; Frewen, P; Théberge, J; Michela, A; Kluetsch, R; Mueller, A; Candrian, G; Jetly, R; Vuilleumier, P; Lanius, R A

2017-10-01

Brain oscillations exhibit long-range temporal correlations (LRTCs), which reflect the regularity of their fluctuations: low values representing more random (decorrelated) while high values more persistent (correlated) dynamics. LRTCs constitute supporting evidence that the brain operates near criticality, a state where neuronal activities are balanced between order and randomness. Here, healthy adults used closed-loop brain training (neurofeedback, NFB) to reduce the amplitude of alpha oscillations, producing a significant increase in spontaneous LRTCs post-training. This effect was reproduced in patients with post-traumatic stress disorder, where abnormally random dynamics were reversed by NFB, correlating with significant improvements in hyperarousal. Notably, regions manifesting abnormally low LRTCs (i.e., excessive randomness) normalized toward healthy population levels, consistent with theoretical predictions about self-organized criticality. Hence, when exposed to appropriate training, spontaneous cortical activity reveals a residual capacity for "self-tuning" its own temporal complexity, despite manifesting the abnormal dynamics seen in individuals with psychiatric disorder. Lastly, we observed an inverse-U relationship between strength of LRTC and oscillation amplitude, suggesting a breakdown of long-range dependence at high/low synchronization extremes, in line with recent computational models. Together, our findings offer a broader mechanistic framework for motivating research and clinical applications of NFB, encompassing disorders with perturbed LRTCs. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Spontaneous brain activity predicts learning ability of foreign sounds.

Science.gov (United States)

Ventura-Campos, Noelia; Sanjuán, Ana; González, Julio; Palomar-García, María-Ángeles; Rodríguez-Pujadas, Aina; Sebastián-Gallés, Núria; Deco, Gustavo; Ávila, César

2013-05-29

Can learning capacity of the human brain be predicted from initial spontaneous functional connectivity (FC) between brain areas involved in a task? We combined task-related functional magnetic resonance imaging (fMRI) and resting-state fMRI (rs-fMRI) before and after training with a Hindi dental-retroflex nonnative contrast. Previous fMRI results were replicated, demonstrating that this learning recruited the left insula/frontal operculum and the left superior parietal lobe, among other areas of the brain. Crucially, resting-state FC (rs-FC) between these two areas at pretraining predicted individual differences in learning outcomes after distributed (Experiment 1) and intensive training (Experiment 2). Furthermore, this rs-FC was reduced at posttraining, a change that may also account for learning. Finally, resting-state network analyses showed that the mechanism underlying this reduction of rs-FC was mainly a transfer in intrinsic activity of the left frontal operculum/anterior insula from the left frontoparietal network to the salience network. Thus, rs-FC may contribute to predict learning ability and to understand how learning modifies the functioning of the brain. The discovery of this correspondence between initial spontaneous brain activity in task-related areas and posttraining performance opens new avenues to find predictors of learning capacities in the brain using task-related fMRI and rs-fMRI combined.

Noise in attractor networks in the brain produced by graded firing rate representations.

Directory of Open Access Journals (Sweden)

Tristan J Webb

Full Text Available Representations in the cortex are often distributed with graded firing rates in the neuronal populations. The firing rate probability distribution of each neuron to a set of stimuli is often exponential or gamma. In processes in the brain, such as decision-making, that are influenced by the noise produced by the close to random spike timings of each neuron for a given mean rate, the noise with this graded type of representation may be larger than with the binary firing rate distribution that is usually investigated. In integrate-and-fire simulations of an attractor decision-making network, we show that the noise is indeed greater for a given sparseness of the representation for graded, exponential, than for binary firing rate distributions. The greater noise was measured by faster escaping times from the spontaneous firing rate state when the decision cues are applied, and this corresponds to faster decision or reaction times. The greater noise was also evident as less stability of the spontaneous firing state before the decision cues are applied. The implication is that spiking-related noise will continue to be a factor that influences processes such as decision-making, signal detection, short-term memory, and memory recall even with the quite large networks found in the cerebral cortex. In these networks there are several thousand recurrent collateral synapses onto each neuron. The greater noise with graded firing rate distributions has the advantage that it can increase the speed of operation of cortical circuitry.

Bidirectional global spontaneous network activity precedes the canonical unidirectional circuit organization in the developing hippocampus.

Science.gov (United States)

Shi, Yulin; Ikrar, Taruna; Olivas, Nicholas D; Xu, Xiangmin

2014-06-15

Spontaneous network activity is believed to sculpt developing neural circuits. Spontaneous giant depolarizing potentials (GDPs) were first identified with single-cell recordings from rat CA3 pyramidal neurons, but here we identify and characterize a large-scale spontaneous network activity we term global network activation (GNA) in the developing mouse hippocampal slices, which is measured macroscopically by fast voltage-sensitive dye imaging. The initiation and propagation of GNA in the mouse is largely GABA-independent and dominated by glutamatergic transmission via AMPA receptors. Despite the fact that signal propagation in the adult hippocampus is strongly unidirectional through the canonical trisynaptic circuit (dentate gyrus [DG] to CA3 to CA1), spontaneous GNA in the developing hippocampus originates in distal CA3 and propagates both forward to CA1 and backward to DG. Photostimulation-evoked GNA also shows prominent backward propagation in the developing hippocampus from CA3 to DG. Mouse GNA is strongly correlated to electrophysiological recordings of highly localized single-cell and local field potential events. Photostimulation mapping of neural circuitry demonstrates that the enhancement of local circuit connections to excitatory pyramidal neurons occurs over the same time course as GNA and reveals the underlying pathways accounting for GNA backward propagation from CA3 to DG. The disappearance of GNA coincides with a transition to the adult-like unidirectional circuit organization at about 2 weeks of age. Taken together, our findings strongly suggest a critical link between GNA activity and maturation of functional circuit connections in the developing hippocampus. Copyright © 2013 Wiley Periodicals, Inc.

Outcomes of Nulliparous Women with Spontaneous Labor Onset Admitted to Hospitals in Pre-active versus Active Labor

Science.gov (United States)

NEAL, Jeremy L.; LAMP, Jane M.; BUCK, Jacalyn S.; LOWE, Nancy K.; GILLESPIE, Shannon L.; RYAN, Sharon L.

2014-01-01

Introduction The timing of when a woman is admitted to the hospital for labor care following spontaneous contraction onset may be among the most important decisions that labor attendants make as it can influence care patterns and birth outcomes. The aims of this study were to estimate the percentage of low-risk, nulliparous women at term who are admitted to labor units prior to active labor and to evaluate the effects of the timing of admission (i.e., pre-active versus active labor) on labor interventions and mode of birth. Methods Obstetrics data from low-risk, nulliparous women with spontaneous labor onset at term gestation (N = 216) were merged from two prospective studies conducted at three large, Midwestern hospitals. Baseline characteristics, labor interventions, and outcomes were compared between groups using Fisher’s exact and Mann-Whitney U tests, as appropriate. Likelihoods for oxytocin augmentation, amniotomy, and cesarean delivery were assessed by logistic regression. Results Of the sample of 216 low-risk nulliparous women, 114 (52.8%) were admitted in pre-active labor and 102 (47.2%) were admitted in active labor. Women admitted in pre-active labor were more likely to undergo oxytocin augmentation (84.2% and 45.1%, respectively; odds ratio (OR) 6.5, 95% confidence interval (CI) 3.43–12.27) but not amniotomy (55.3% and 61.8%, respectively; OR 0.8, 95% CI 0.44–1.32) when compared to women admitted in active labor. The likelihood of cesarean delivery was higher for women admitted before active labor onset (15.8% and 6.9%, respectively; OR 2.6, 95% CI 1.02–6.37). Discussion Many low-risk nulliparous women with regular, spontaneous uterine contractions are admitted to labor units before active labor onset, which increases their likelihood of receiving oxytocin and being delivered via cesarean section. An evidence-based, standardized approach for labor admission decision-making is recommended to decrease inadvertent admissions of women in pre-active

An Overview of Recent Geostationary Fire Monitoring Activities and Applications in the Western Hemisphere

Science.gov (United States)

McRae, D. J.; Conard, S. G.; Ivanova, G. A.; Sukhinin, A. I.; Hao, W. M.; Koutzenogii, K. P.; Prins, E. M.; Schmidt, C. C.; Feltz, J. M.

2002-05-01

Over the past twenty years the international scientific research and environmental monitoring communities have recognized the vital role environmental satellites can play in detecting and monitoring active fires both regionally and around the globe for hazards applications and to better understand the extent and impact of biomass burning on the global environment. Both groups have stressed the importance of utilizing operational satellites to produce routine fire products and to ensure long-term stable records of fire activity for applications such as land-use/land cover change analyses and global climate change research. The current NOAA GOES system provides the unique opportunity to detect fires throughout the Western Hemisphere every half-hour from a series of nearly identical satellites for a period of 15+ years. This presentation will provide an overview of the GOES biomass burning monitoring program at UW-Madison Cooperative Institute for Meteorological Satellite Studies (CIMSS) with an emphasis on recent applications of the new GOES Wildfire Automated Biomass Burning Algorithm (WF_ABBA). For the past 8 years, CIMSS has utilized the GOES-8 imager to monitor biomass burning trends in South America. Since September 2000, CIMSS has been producing half-hourly fire products in real-time for most of the Western Hemisphere. The WF_ABBA half-hourly fire product is providing new insights into diurnal, spatial, seasonal and interannual fire dynamics in North, Central, and South America. In North America these products are utilized to detect and monitor wildfires in northerly and remote locations. In South America the diurnal GOES fire product is being used as an indicator of land-use and land-cover change and carbon dynamics along the borders between Brazil, Peru, and Bolivia. The Navy is assimilating the Wildfire ABBA fire product into the Navy Aerosol Analysis and Prediction System (NAAPS) to analyze and predict aerosol loading and transport as part of the NASA

Altered spontaneous brain activity in patients with acute spinal cord injury revealed by resting-state functional MRI.

Directory of Open Access Journals (Sweden)

Ling Zhu

Full Text Available Previous neuroimaging studies have provided evidence of structural and functional reorganization of brain in patients with chronic spinal cord injury (SCI. However, it remains unknown whether the spontaneous brain activity changes in acute SCI. In this study, we investigated intrinsic brain activity in acute SCI patients using a regional homogeneity (ReHo analysis based on resting-state functional magnetic resonance imaging.A total of 15 patients with acute SCI and 16 healthy controls participated in the study. The ReHo value was used to evaluate spontaneous brain activity, and voxel-wise comparisons of ReHo were performed to identify brain regions with altered spontaneous brain activity between groups. We also assessed the associations between ReHo and the clinical scores in brain regions showing changed spontaneous brain activity.Compared with the controls, the acute SCI patients showed decreased ReHo in the bilateral primary motor cortex/primary somatosensory cortex, bilateral supplementary motor area/dorsal lateral prefrontal cortex, right inferior frontal gyrus, bilateral dorsal anterior cingulate cortex and bilateral caudate; and increased ReHo in bilateral precuneus, the left inferior parietal lobe, the left brainstem/hippocampus, the left cingulate motor area, bilateral insula, bilateral thalamus and bilateral cerebellum. The average ReHo values of the left thalamus and right insula were negatively correlated with the international standards for the neurological classification of spinal cord injury motor scores.Our findings indicate that acute distant neuronal damage has an immediate impact on spontaneous brain activity. In acute SCI patients, the ReHo was prominently altered in brain regions involved in motor execution and cognitive control, default mode network, and which are associated with sensorimotor compensatory reorganization. Abnormal ReHo values in the left thalamus and right insula could serve as potential biomarkers for

Effects of DISC1 Polymorphisms on Resting-State Spontaneous Neuronal Activity in the Early-Stage of Schizophrenia

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Ningzhi Gou

2018-05-01

Full Text Available Background: Localized abnormalities in the synchrony of spontaneous neuronal activity, measured with regional homogeneity (ReHo, has been consistently reported in patients with schizophrenia (SCZ and their unaffected siblings. To date, little is known about the genetic influences affecting the spontaneous neuronal activity in SCZ. DISC1, a strong susceptible gene for SCZ, has been implicated in neuronal excitability and synaptic function possibly associated with regional spontaneous neuronal activity. This study aimed to examine the effects of DISC1 variations on the regional spontaneous neuronal activity in SCZ.Methods: Resting-state fMRI data were obtained from 28 SCZ patients and 21 healthy controls (HC for ReHo analysis. Six single nucleotide polymorphisms (SNPs of DISC1 gene were genotyped using the PCR and direct sequencing.Results: Significant diagnosis × genotype interactions were noted for three SNPs (rs821616, rs821617, and rs2738880. For rs821617, the interactions were localized to the precuneus, basal ganglia and pre-/post-central regions. Significant interactive effects were identified at the temporal and post-central gyri for rs821616 (Ser704Cys and the inferior temporal gyrus for rs2738880. Furthermore, post-hoc analysis revealed that the DISC1 variations on these SNPs exerted different influences on ReHo between SCZ patients and HC.Conclusion: To our knowledge this is the first study to unpick the influence of DISC1 variations on spontaneous neuronal activity in SCZ; Given the emerging evidence that ReHo is a stable inheritable phenotype for schizophrenia, our findings suggest the DISC1 variations are possibly an inheritable source for the altered ReHo in this disorder.

Stereotypic wheel running decreases cortical activity in mice

Science.gov (United States)

Fisher, Simon P.; Cui, Nanyi; McKillop, Laura E.; Gemignani, Jessica; Bannerman, David M.; Oliver, Peter L.; Peirson, Stuart N.; Vyazovskiy, Vladyslav V.

2016-01-01

Prolonged wakefulness is thought to gradually increase ‘sleep need' and influence subsequent sleep duration and intensity, but the role of specific waking behaviours remains unclear. Here we report the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somatosensory cortex in mice. We find that stereotypic wheel running is associated with a substantial reduction in firing rates among a large subpopulation of cortical neurons, especially at high speeds. Wheel running also has longer-term effects on spiking activity across periods of wakefulness. Specifically, cortical firing rates are significantly higher towards the end of a spontaneous prolonged waking period. However, this increase is abolished when wakefulness is dominated by running wheel activity. These findings indicate that wake-related changes in firing rates are determined not only by wake duration, but also by specific waking behaviours. PMID:27748455

Forest fires in Pennsylvania.

Science.gov (United States)

Donald A. Haines; William A. Main; Eugene F. McNamara

1978-01-01

Describes factors that contribute to forest fires in Pennsylvania. Includes an analysis of basic statistics; distribution of fires during normal, drought, and wet years; fire cause, fire activity by day-of-week; multiple-fire day; and fire climatology.

The Impact of Stimulation Induced Short Term Synaptic Plasticity on Firing Patterns in the Globus Pallidus of the Rat

Directory of Open Access Journals (Sweden)

Jenia eBugaysen

2011-03-01

Full Text Available Electrical stimulation in the globus pallidus (GP leads to complex modulations of neuronal activity in the stimulated nucleus. Multiple in-vivo studies have demonstrated the modulation of both firing rates and patterns during and immediately following the GP stimulation. Previous in-vitro studies, together with computational studies, have suggested the involvement of short-term synaptic plasticity (STP during the stimulation. The aim of the current study was to explore in-vitro the effects of STP on neuronal activity of GP neurons during local repetitive stimulation. We recorded synaptic potentials and assessed the modulations of spontaneous firing in a postsynaptic neuron in acute brain slices via a whole-cell pipette. Low-frequency repetitive stimulation locked the firing of the neuron to the stimulus. However, high-frequency repetitive stimulation in the GP generated a biphasic modulation of the firing frequency consisting of inhibitory and excitatory phases. Using blockers of synaptic transmission, we show that GABAergic synapses mediated the inhibitory and glutamatergic synapses the excitatory part of the response. Furthermore, we report that at high stimulation frequencies both types of synapses undergo short-term depression leading to a time dependent modulation of the neuronal firing. These findings indicate that STP modulates the dynamic responses of pallidal activity during electrical stimulation, and may contribute to a better understanding of the mechanism underlying deep brain stimulation (DBS like protocols.

105-DR Large Sodium Fire Facility closure activities evaluation report

International Nuclear Information System (INIS)

Adler, J.G.

1996-01-01

This report evaluates the closure activities at the 105-DR Large Sodium Fire Facility. The closure activities discussed include: the closure activities for the structures, equipment, soil, and gravel scrubber; decontamination methods; materials made available for recycling or reuse; and waste management. The evaluation compares these activities to the regulatory requirements and closure plan requirements. The report concludes that the areas identified in the closure plan can be clean closed

Dorsomedial prefontal cortex supports spontaneous thinking per se.

Science.gov (United States)

Raij, T T; Riekki, T J J

2017-06-01

Spontaneous thinking, an action to produce, consider, integrate, and reason through mental representations, is central to our daily experience and has been suggested to serve crucial adaptive purposes. Such thinking occurs among other experiences during mind wandering that is associated with activation of the default mode network among other brain circuitries. Whether and how such brain activation is linked to the experience of spontaneous thinking per se remains poorly known. We studied 51 healthy subjects using a comprehensive experience-sampling paradigm during 3T functional magnetic resonance imaging. In comparison with fixation, the experiences of spontaneous thinking and spontaneous perception were related to activation of wide-spread brain circuitries, including the cortical midline structures, the anterior cingulate cortex and the visual cortex. In direct comparison of the spontaneous thinking versus spontaneous perception, activation was observed in the anterior dorsomedial prefrontal cortex. Modality congruence of spontaneous-experience-related brain activation was suggested by several findings, including association of the lingual gyrus with visual in comparison with non-verbal-non-visual thinking. In the context of current literature, these findings suggest that the cortical midline structures are involved in the integrative core substrate of spontaneous thinking that is coupled with other brain systems depending on the characteristics of thinking. Furthermore, involvement of the anterior dorsomedial prefrontal cortex suggests the control of high-order abstract functions to characterize spontaneous thinking per se. Hum Brain Mapp 38:3277-3288, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Burns resulting from spontaneous combustion of electronic cigarettes: a case series.

Science.gov (United States)

Sheckter, Clifford; Chattopadhyay, Arhana; Paro, John; Karanas, Yvonne

2016-01-01

Electronic cigarette (e-cigarette) sales have grown rapidly in recent years, coinciding with a public perception that they are a safer alternative to traditional cigarettes. However, there have been numerous media reports of fires associated with e-cigarette spontaneous combustion. Three severe burns caused by spontaneous combustion of e-cigarettes within a 6-month period were treated at the Santa Clara Valley Medical Center Burn Unit. Patients sustained partial and full-thickness burns. Two required hospitalization and surgical treatment. E-cigarettes are dangerous devices and have the potential to cause significant burns. Consumers and the general public should be made aware of these life-threatening devices.

Incorporating Anthropogenic Influences into Fire Probability Models: Effects of Human Activity and Climate Change on Fire Activity in California.

Science.gov (United States)

Mann, Michael L; Batllori, Enric; Moritz, Max A; Waller, Eric K; Berck, Peter; Flint, Alan L; Flint, Lorraine E; Dolfi, Emmalee

2016-01-01

The costly interactions between humans and wildfires throughout California demonstrate the need to understand the relationships between them, especially in the face of a changing climate and expanding human communities. Although a number of statistical and process-based wildfire models exist for California, there is enormous uncertainty about the location and number of future fires, with previously published estimates of increases ranging from nine to fifty-three percent by the end of the century. Our goal is to assess the role of climate and anthropogenic influences on the state's fire regimes from 1975 to 2050. We develop an empirical model that integrates estimates of biophysical indicators relevant to plant communities and anthropogenic influences at each forecast time step. Historically, we find that anthropogenic influences account for up to fifty percent of explanatory power in the model. We also find that the total area burned is likely to increase, with burned area expected to increase by 2.2 and 5.0 percent by 2050 under climatic bookends (PCM and GFDL climate models, respectively). Our two climate models show considerable agreement, but due to potential shifts in rainfall patterns, substantial uncertainty remains for the semiarid inland deserts and coastal areas of the south. Given the strength of human-related variables in some regions, however, it is clear that comprehensive projections of future fire activity should include both anthropogenic and biophysical influences. Previous findings of substantially increased numbers of fires and burned area for California may be tied to omitted variable bias from the exclusion of human influences. The omission of anthropogenic variables in our model would overstate the importance of climatic ones by at least 24%. As such, the failure to include anthropogenic effects in many models likely overstates the response of wildfire to climatic change.

Incorporating Anthropogenic Influences into Fire Probability Models: Effects of Human Activity and Climate Change on Fire Activity in California.

Directory of Open Access Journals (Sweden)

Michael L Mann

Full Text Available The costly interactions between humans and wildfires throughout California demonstrate the need to understand the relationships between them, especially in the face of a changing climate and expanding human communities. Although a number of statistical and process-based wildfire models exist for California, there is enormous uncertainty about the location and number of future fires, with previously published estimates of increases ranging from nine to fifty-three percent by the end of the century. Our goal is to assess the role of climate and anthropogenic influences on the state's fire regimes from 1975 to 2050. We develop an empirical model that integrates estimates of biophysical indicators relevant to plant communities and anthropogenic influences at each forecast time step. Historically, we find that anthropogenic influences account for up to fifty percent of explanatory power in the model. We also find that the total area burned is likely to increase, with burned area expected to increase by 2.2 and 5.0 percent by 2050 under climatic bookends (PCM and GFDL climate models, respectively. Our two climate models show considerable agreement, but due to potential shifts in rainfall patterns, substantial uncertainty remains for the semiarid inland deserts and coastal areas of the south. Given the strength of human-related variables in some regions, however, it is clear that comprehensive projections of future fire activity should include both anthropogenic and biophysical influences. Previous findings of substantially increased numbers of fires and burned area for California may be tied to omitted variable bias from the exclusion of human influences. The omission of anthropogenic variables in our model would overstate the importance of climatic ones by at least 24%. As such, the failure to include anthropogenic effects in many models likely overstates the response of wildfire to climatic change.

Spontaneous Brain Activity Did Not Show the Effect of Violent Video Games on Aggression: A Resting-State fMRI Study

Science.gov (United States)

Pan, Wei; Gao, Xuemei; Shi, Shuo; Liu, Fuqu; Li, Chao

2018-01-01

A great many of empirical researches have proved that longtime exposure to violent video game can lead to a series of negative effects. Although research has focused on the neural basis of the correlation between violent video game and aggression, little is known whether the spontaneous brain activity is associated with violent video game exposure. To address this question, we measured the spontaneous brain activity using resting-state functional magnetic resonance imaging (fMRI). We used the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) to quantify spontaneous brain activity. The results showed there is no significant difference in ALFF, or fALFF, between violent video game group and the control part, indicating that long time exposure to violent video games won’t significantly influence spontaneous brain activity, especially the core brain regions such as execution control, moral judgment and short-term memory. This implies the adverse impact of violent video games is exaggerated. PMID:29375416

Spontaneous Brain Activity Did Not Show the Effect of Violent Video Games on Aggression: A Resting-State fMRI Study.

Science.gov (United States)

Pan, Wei; Gao, Xuemei; Shi, Shuo; Liu, Fuqu; Li, Chao

2017-01-01

A great many of empirical researches have proved that longtime exposure to violent video game can lead to a series of negative effects. Although research has focused on the neural basis of the correlation between violent video game and aggression, little is known whether the spontaneous brain activity is associated with violent video game exposure. To address this question, we measured the spontaneous brain activity using resting-state functional magnetic resonance imaging (fMRI). We used the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) to quantify spontaneous brain activity. The results showed there is no significant difference in ALFF, or fALFF, between violent video game group and the control part, indicating that long time exposure to violent video games won't significantly influence spontaneous brain activity, especially the core brain regions such as execution control, moral judgment and short-term memory. This implies the adverse impact of violent video games is exaggerated.

Spontaneous Brain Activity Did Not Show the Effect of Violent Video Games on Aggression: A Resting-State fMRI Study

Directory of Open Access Journals (Sweden)

Wei Pan

2018-01-01

Full Text Available A great many of empirical researches have proved that longtime exposure to violent video game can lead to a series of negative effects. Although research has focused on the neural basis of the correlation between violent video game and aggression, little is known whether the spontaneous brain activity is associated with violent video game exposure. To address this question, we measured the spontaneous brain activity using resting-state functional magnetic resonance imaging (fMRI. We used the amplitude of low-frequency fluctuations (ALFF and fractional ALFF (fALFF to quantify spontaneous brain activity. The results showed there is no significant difference in ALFF, or fALFF, between violent video game group and the control part, indicating that long time exposure to violent video games won’t significantly influence spontaneous brain activity, especially the core brain regions such as execution control, moral judgment and short-term memory. This implies the adverse impact of violent video games is exaggerated.

Slow-light enhancement of spontaneous emission in active photonic crystal waveguides

DEFF Research Database (Denmark)

Ek, Sara; Chen, Yaohui; Semenova, Elizaveta

2012-01-01

Photonic crystal defect waveguides with embedded active layers containing single or multiple quantum wells or quantum dots have been fabricated. Spontaneous emission spectra are enhanced close to the bandedge, consistently with the enhancement of gain by slow light effects. These are promising...... results for future compact devices for terabit/s communication, such as miniaturised semiconductor optical amplifiers and mode-locked lasers....

Forest fires caused by lightning activity in Portugal

Science.gov (United States)

Russo, Ana; Ramos, Alexandre M.; Benali, Akli; Trigo, Ricardo M.

2017-04-01

and Atmosphere (IPMA). The main objective of this work was to evaluate and quantify the relations between the wildfires' occurrence and the lightning activity. In particularly we were able to verify if wildfires which were identified as "ignited by lightning" by comparing its location to the lightning discharges location database. Furthermore we have also investigated possible fire ignition by lightning discharges that have not yet been labeled in the PRFD by comparing daily data from both datasets. - Bastos A., Gouveia C.M., Trigo R.M., Running S.W., 2014. Biogeosciences, 11, 3421-3435. - Pereira M.G., B.D. Malamud R.M. Trigo, P.I. Alves, 2011. Nat. Hazards Earth Syst. Sci., 11, 3343-3358. - Gouveia C., Trigo R.M., DaCamara C.C., 2009. Nat. Hazards Earth Syst. Sci., 9, 185-195 - Gouveia C.M., Bistinas I., Liberato M.L.R., Bastos A., Koutsiasd N., Trigo R., 2016. Agricultural and Forest Meteorology, 218-219, 135-145. Acknowledgements Research performed was supported by FAPESP/FCT Project Brazilian Fire-Land-Atmosphere System (BrFLAS) (1389/2014 and 2015/01389-4). Ana Russo thanks FCT for granted support (SFRH/BPD/99757/2014). A. M. Ramos was also supported by a FCT postdoctoral grant (FCT/DFRH/ SFRH/BPD/84328/2012).

Characterization of the Fire Regime and Drivers of Fires in the West African Tropical Forest

Science.gov (United States)

Dwomoh, F. K.; Wimberly, M. C.

2016-12-01

The Upper Guinean forest (UGF), encompassing the tropical regions of West Africa, is a globally significant biodiversity hotspot and a critically important socio-economic and ecological resource for the region. However, the UGF is one of the most human-disturbed tropical forest ecosystems with the only remaining large patches of original forests distributed in protected areas, which are embedded in a hotspot of climate stress & land use pressures, increasing their vulnerability to fire. We hypothesized that human impacts and climate interact to drive spatial and temporal variability in fire, with fire exhibiting distinctive seasonality and sensitivity to drought in areas characterized by different population densities, agricultural practices, vegetation types, and levels of forest degradation. We used the MODIS active fire product to identify and characterize fire activity in the major ecoregions of the UGF. We used TRMM rainfall data to measure climatic variability and derived indicators of human land use from a variety of geospatial datasets. We employed time series modeling to identify the influences of drought indices and other antecedent climatic indicators on temporal patterns of active fire occurrence. We used a variety of modeling approaches to assess the influences of human activities and land cover variables on the spatial pattern of fire activity. Our results showed that temporal patterns of fire activity in the UGF were related to precipitation, but these relationships were spatially heterogeneous. The pattern of fire seasonality varied geographically, reflecting both climatological patterns and agricultural practices. The spatial pattern of fire activity was strongly associated with vegetation gradients and anthropogenic activities occurring at fine spatial scales. The Guinean forest-savanna mosaic ecoregion had the most fires. This study contributes to our understanding of UGF fire regime and the spatio-temporal dynamics of tropical forest fires in

Thermal surface characteristics of coal fires 1 results of in-situ measurements

Science.gov (United States)

Zhang, Jianzhong; Kuenzer, Claudia

2007-12-01

Natural underground coal fires are fires in coal seams occurring subsurface. The fires are ignited through a process named spontaneous combustion, which occurs based on a natural reaction but is usually triggered through human interaction. Coal mining activities expose coal to the air. This leads to the exothermal oxidation of the carbon in the coal with the air's oxygen to CO 2 and - under certain circumstances - to spontaneous combustion. Coal fires occur in many countries world wide - however, currently the Chinese coal mining industry faces the biggest problems with coal fires. Coal fires destroy the valuable resource coal and furthermore lead to many environmental degradation phenomena such as the deterioration of surrounding vegetation, land subsidence and the emission of toxic gasses (CO, N 2O). They additionally contribute to the emission of green house relevant gasses such as CO 2 and CH 4 to the atmosphere. In this paper we present thermal characteristics of coal fires as measured in-situ during a field campaign to the Wuda coal fire area in south-central Inner Mongolia, China. Thermal characteristics include temperature anomaly measurements at the surface, spatial surface temperature profiles of fire areas and unaffected background areas, diurnal temperature profiles, and temperature measurements inside of coal fire induced cracks in the overlying bedrock. For all the measurements the effects of uneven solar heating through influences of slope and aspect are considered. Our findings show that coal fires result in strong or subtle thermal surface anomalies. Especially the latter can easily be influenced by heating of the surrounding background material through solar influences. Temperature variation of background rocks with different albedo, slope, aspect or vegetation cover can substantially influence the detectability of thermal anomalies. In the worst case coal fire related thermal anomalies can be completely masked by solar patterns during the daytime

Prophage spontaneous activation promotes DNA release enhancing biofilm formation in Streptococcus pneumoniae.

Directory of Open Access Journals (Sweden)

Margarida Carrolo

Full Text Available Streptococcus pneumoniae (pneumococcus is able to form biofilms in vivo and previous studies propose that pneumococcal biofilms play a relevant role both in colonization and infection. Additionally, pneumococci recovered from human infections are characterized by a high prevalence of lysogenic bacteriophages (phages residing quiescently in their host chromosome. We investigated a possible link between lysogeny and biofilm formation. Considering that extracellular DNA (eDNA is a key factor in the biofilm matrix, we reasoned that prophage spontaneous activation with the consequent bacterial host lysis could provide a source of eDNA, enhancing pneumococcal biofilm development. Monitoring biofilm growth of lysogenic and non-lysogenic pneumococcal strains indicated that phage-infected bacteria are more proficient at forming biofilms, that is their biofilms are characterized by a higher biomass and cell viability. The presence of phage particles throughout the lysogenic strains biofilm development implicated prophage spontaneous induction in this effect. Analysis of lysogens deficient for phage lysin and the bacterial major autolysin revealed that the absence of either lytic activity impaired biofilm development and the addition of DNA restored the ability of mutant strains to form robust biofilms. These findings establish that limited phage-mediated host lysis of a fraction of the bacterial population, due to spontaneous phage induction, constitutes an important source of eDNA for the S. pneumoniae biofilm matrix and that this localized release of eDNA favors biofilm formation by the remaining bacterial population.

Brain modularity controls the critical behavior of spontaneous activity.

Science.gov (United States)

Russo, R; Herrmann, H J; de Arcangelis, L

2014-03-13

The human brain exhibits a complex structure made of scale-free highly connected modules loosely interconnected by weaker links to form a small-world network. These features appear in healthy patients whereas neurological diseases often modify this structure. An important open question concerns the role of brain modularity in sustaining the critical behaviour of spontaneous activity. Here we analyse the neuronal activity of a model, successful in reproducing on non-modular networks the scaling behaviour observed in experimental data, on a modular network implementing the main statistical features measured in human brain. We show that on a modular network, regardless the strength of the synaptic connections or the modular size and number, activity is never fully scale-free. Neuronal avalanches can invade different modules which results in an activity depression, hindering further avalanche propagation. Critical behaviour is solely recovered if inter-module connections are added, modifying the modular into a more random structure.

Spontaneous recombinase activity of Cre-ERT2 in vivo.

Science.gov (United States)

Kristianto, Jasmin; Johnson, Michael G; Zastrow, Ryley K; Radcliff, Abigail B; Blank, Robert D

2017-06-01

Inducible Cre-ERT recombinase technology is widely used for gene targeting studies. The second generation of inducible Cre-ERT recombinase, hemizygous B6.129S-Tg(UBC-cre/ERT2)1Ejb/J (hereafter abbreviated as Cre-ERT2), a fusion of a mutated estrogen receptor and Cre recombinase, was engineered to be more efficient and specific than the original Cre-ERT. The putative mechanism of selective Cre-mediated recombination is Cre sequestration in the cytoplasm in the basal state with translocation to the nucleus only in the presence of tamoxifen. We utilized both a reporter mouse (B6.129 (Cg)-Gt(ROSA)26Sor tm4(ACTB-tdTomato,-EGFP)Luo /J) and endothelin converting enzyme-1 floxed transgenic mouse line to evaluate Cre-ERT2 activity. We observed spontaneous Cre activity in both settings. Unintended Cre activity is a confounding factor that has a potentially large impact on data interpretation. Thus, it is important to consider background Cre activity in experimental design.

Nitric Oxide Orchestrates a Power-Law Modulation of Sympathetic Firing Behaviors in Neonatal Rat Spinal Cords

Directory of Open Access Journals (Sweden)

Chun-Kuei Su

2018-03-01

Full Text Available Nitric oxide (NO is a diffusible gas and has multifarious effects on both pre- and postsynaptic events. As a consequence of complex excitatory and inhibitory integrations, NO effects on neuronal activities are heterogeneous. Using in vitro preparations of neonatal rats that retain the splanchnic sympathetic nerves and the thoracic spinal cord as an experimental model, we report here that either enhancement or attenuation of NO production in the neonatal rat spinal cords could increase, decrease, or not change the spontaneous firing behaviors recorded from splanchnic sympathetic single fibers. To elucidate the mathematical features of NO-mediated heterogeneous responses, the ratios of changes in firing were plotted against their original firing rates. In log-log plots, a linear data distribution demonstrated that NO-mediated heterogeneity in sympathetic firing responses was well described by a power function. Selective antagonists were applied to test if glycinergic, GABAergic, glutamatergic, and cholinergic neurotransmission in the spinal cord are involved in NO-mediated power-law firing modulations (plFM. NO-mediated plFM diminished in the presence of mecamylamine (an open-channel blocker of nicotinic cholinergic receptors, indicating that endogenous nicotinic receptor activities were essential for plFM. Applications of strychnine (a glycine receptor blocker, gabazine (a GABAA receptor blocker, or kynurenate (a broad-spectrum ionotropic glutamate receptor blocker also caused plFM. However, strychnine- or kynurenate-induced plFM was diminished by L-NAME (an NO synthase inhibitor pretreatments, indicating that the involvements of glycine or ionotropic glutamate receptor activities in plFM were secondary to NO signaling. To recapitulate the arithmetic natures of the plFM, the plFM were simulated by firing changes in two components: a step increment and a fractional reduction of their basal firing activities. Ionotropic glutamate receptor

Neural activation and memory for natural scenes: Explicit and spontaneous retrieval.

Science.gov (United States)

Weymar, Mathias; Bradley, Margaret M; Sege, Christopher T; Lang, Peter J

2018-05-06

Stimulus repetition elicits either enhancement or suppression in neural activity, and a recent fMRI meta-analysis of repetition effects for visual stimuli (Kim, 2017) reported cross-stimulus repetition enhancement in medial and lateral parietal cortex, as well as regions of prefrontal, temporal, and posterior cingulate cortex. Repetition enhancement was assessed here for repeated and novel scenes presented in the context of either an explicit episodic recognition task or an implicit judgment task, in order to study the role of spontaneous retrieval of episodic memories. Regardless of whether episodic memory was explicitly probed or not, repetition enhancement was found in medial posterior parietal (precuneus/cuneus), lateral parietal cortex (angular gyrus), as well as in medial prefrontal cortex (frontopolar), which did not differ by task. Enhancement effects in the posterior cingulate cortex were significantly larger during explicit compared to implicit task, primarily due to a lack of functional activity for new scenes. Taken together, the data are consistent with an interpretation that medial and (ventral) lateral parietal cortex are associated with spontaneous episodic retrieval, whereas posterior cingulate cortical regions may reflect task or decision processes. © 2018 Society for Psychophysiological Research.

Evaluating greenhouse gas emissions inventories for agricultural burning using satellite observations of active fires.

Science.gov (United States)

Lin, Hsiao-Wen; Jin, Yufang; Giglio, Louis; Foley, Jonathan A; Randerson, James T

2012-06-01

Fires in agricultural ecosystems emit greenhouse gases and aerosols that influence climate on multiple spatial and temporal scales. Annex 1 countries of the United Nations Framework Convention on Climate Change (UNFCCC), many of which ratified the Kyoto Protocol, are required to report emissions of CH4 and N2O from these fires annually. In this study, we evaluated several aspects of this reporting system, including the optimality of the crops targeted by the UNFCCC globally and within Annex 1 countries, and the consistency of emissions inventories among different countries. We also evaluated the success of individual countries in capturing interannual variability and long-term trends in agricultural fire activity. In our approach, we combined global high-resolution maps of crop harvest area and production, derived from satellite maps and ground-based census data, with Terra and Aqua Moderate Resolution Imaging Spectroradiometer (MODIS) measurements of active fires. At a global scale, we found that adding ground nuts (e.g., peanuts), cocoa, cotton and oil palm, and removing potato, oats, rye, and pulse other from the list of 14 crops targeted by the UNFCCC increased the percentage of active fires covered by the reporting system by 9%. Optimization led to a different recommended list for Annex 1 countries, requiring the addition of sunflower, cotton, rapeseed, and alfalfa and the removal of beans, sugarcane, pulse others, and tuber-root others. Extending emissions reporting to all Annex 1 countries (from the current set of 19 countries) would increase the efficacy of the reporting system from 6% to 15%, and further including several non-Annex 1 countries (Argentina, Brazil, China, India, Indonesia, Thailand, Kazakhstan, Mexico, and Nigeria) would capture over 55% of active fires in croplands worldwide. Analyses of interannual trends from the United States and Australia showed the importance of both intensity of fire use and crop production in controlling year

What Fraction of Global Fire Activity Can Be Forecast Using Sea Surface Temperatures?

Science.gov (United States)

Chen, Y.; Randerson, J. T.; Morton, D. C.; Andela, N.; Giglio, L.

2015-12-01

Variations in sea surface temperatures (SSTs) can influence climate dynamics in local and remote land areas, and thus influence fire-climate interactions that govern burned area. SST information has been recently used in statistical models to create seasonal outlooks of fire season severity in South America and as the initial condition for dynamical model predictions of fire activity in Indonesia. However, the degree to which large-scale ocean-atmosphere interactions can influence burned area in other continental regions has not been systematically explored. Here we quantified the amount of global burned area that can be predicted using SSTs in 14 different oceans regions as statistical predictors. We first examined lagged correlations between GFED4s burned area and the 14 ocean climate indices (OCIs) individually. The maximum correlations from different OCIs were used to construct a global map of fire predictability. About half of the global burned area can be forecast by this approach 3 months before the peak burning month (with a Pearson's r of 0.5 or higher), with the highest levels of predictability in Central America and Equatorial Asia. Several hotspots of predictability were identified using k-means cluster analysis. Within these regions, we tested the improvements of the forecast by using two OCIs from different oceans. Our forecast models were based on near-real-time SST data and may therefore support the development of new seasonal outlooks for fire activity that can aid the sustainable management of these fire-prone ecosystems.

A data-driven approach to identify controls on global fire activity from satellite and climate observations (SOFIA V1

Directory of Open Access Journals (Sweden)

M. Forkel

2017-12-01

Full Text Available Vegetation fires affect human infrastructures, ecosystems, global vegetation distribution, and atmospheric composition. However, the climatic, environmental, and socioeconomic factors that control global fire activity in vegetation are only poorly understood, and in various complexities and formulations are represented in global process-oriented vegetation-fire models. Data-driven model approaches such as machine learning algorithms have successfully been used to identify and better understand controlling factors for fire activity. However, such machine learning models cannot be easily adapted or even implemented within process-oriented global vegetation-fire models. To overcome this gap between machine learning-based approaches and process-oriented global fire models, we introduce a new flexible data-driven fire modelling approach here (Satellite Observations to predict FIre Activity, SOFIA approach version 1. SOFIA models can use several predictor variables and functional relationships to estimate burned area that can be easily adapted with more complex process-oriented vegetation-fire models. We created an ensemble of SOFIA models to test the importance of several predictor variables. SOFIA models result in the highest performance in predicting burned area if they account for a direct restriction of fire activity under wet conditions and if they include a land cover-dependent restriction or allowance of fire activity by vegetation density and biomass. The use of vegetation optical depth data from microwave satellite observations, a proxy for vegetation biomass and water content, reaches higher model performance than commonly used vegetation variables from optical sensors. We further analyse spatial patterns of the sensitivity between anthropogenic, climate, and vegetation predictor variables and burned area. We finally discuss how multiple observational datasets on climate, hydrological, vegetation, and socioeconomic variables together with

A data-driven approach to identify controls on global fire activity from satellite and climate observations (SOFIA V1)

Science.gov (United States)

Forkel, Matthias; Dorigo, Wouter; Lasslop, Gitta; Teubner, Irene; Chuvieco, Emilio; Thonicke, Kirsten

2017-12-01

Vegetation fires affect human infrastructures, ecosystems, global vegetation distribution, and atmospheric composition. However, the climatic, environmental, and socioeconomic factors that control global fire activity in vegetation are only poorly understood, and in various complexities and formulations are represented in global process-oriented vegetation-fire models. Data-driven model approaches such as machine learning algorithms have successfully been used to identify and better understand controlling factors for fire activity. However, such machine learning models cannot be easily adapted or even implemented within process-oriented global vegetation-fire models. To overcome this gap between machine learning-based approaches and process-oriented global fire models, we introduce a new flexible data-driven fire modelling approach here (Satellite Observations to predict FIre Activity, SOFIA approach version 1). SOFIA models can use several predictor variables and functional relationships to estimate burned area that can be easily adapted with more complex process-oriented vegetation-fire models. We created an ensemble of SOFIA models to test the importance of several predictor variables. SOFIA models result in the highest performance in predicting burned area if they account for a direct restriction of fire activity under wet conditions and if they include a land cover-dependent restriction or allowance of fire activity by vegetation density and biomass. The use of vegetation optical depth data from microwave satellite observations, a proxy for vegetation biomass and water content, reaches higher model performance than commonly used vegetation variables from optical sensors. We further analyse spatial patterns of the sensitivity between anthropogenic, climate, and vegetation predictor variables and burned area. We finally discuss how multiple observational datasets on climate, hydrological, vegetation, and socioeconomic variables together with data

Firing patterns of spontaneously active motor units in spinal cord-injured subjects

NARCIS (Netherlands)

Zijdewind, Inge; Thomas, Christine K.

Involuntary motor unit activity at low rates is common in hand muscles paralysed by spinal cord injury. Our aim was to describe these patterns of motor unit behaviour in relation to motoneurone and motor unit properties. Intramuscular electromyographic activity (EMG), surface EMG and force were

On nature of spontaneous elongation of polymers preliminarily stretched in adsorption-active media under irradiation

International Nuclear Information System (INIS)

Sinevich, E.A.; Prazdnichnyj, A.M.; Tikhomirov, V.S.; Bakeev, N.F.

1989-01-01

The nature of the spontaneous elongation under irradiation with fast electrons of polymers preliminary stretched in adsorption-active media has been studied. This effect is related with radiation-induced heating of microporous polymer samples. Its manifestation in amorphous PETP requires the presence of crazes having well developed microfibrillar structure. The spontaneous elongation effect is shown to be a result of crystallization of partially oriented material in transitional regions relating the oriented material of microfibrils inside crazes with nonstrained polymer between them

Detection and Characterization of Low Temperature Peat Fires during the 2015 Fire Catastrophe in Indonesia Using a New High-Sensitivity Fire Monitoring Satellite Sensor (FireBird).

Science.gov (United States)

Atwood, Elizabeth C; Englhart, Sandra; Lorenz, Eckehard; Halle, Winfried; Wiedemann, Werner; Siegert, Florian

2016-01-01

Vast and disastrous fires occurred on Borneo during the 2015 dry season, pushing Indonesia into the top five carbon emitting countries. The region was affected by a very strong El Niño-Southern Oscillation (ENSO) climate phenomenon, on par with the last severe event in 1997/98. Fire dynamics in Central Kalimantan were investigated using an innovative sensor offering higher sensitivity to a wider range of fire intensities at a finer spatial resolution (160 m) than heretofore available. The sensor is onboard the TET-1 satellite, part of the German Aerospace Center (DLR) FireBird mission. TET-1 images (acquired every 2-3 days) from the middle infrared were used to detect fires continuously burning for almost three weeks in the protected peatlands of Sebangau National Park as well as surrounding areas with active logging and oil palm concessions. TET-1 detection capabilities were compared with MODIS active fire detection and Landsat burned area algorithms. Fire dynamics, including fire front propagation speed and area burned, were investigated. We show that TET-1 has improved detection capabilities over MODIS in monitoring low-intensity peatland fire fronts through thick smoke and haze. Analysis of fire dynamics revealed that the largest burned areas resulted from fire front lines started from multiple locations, and the highest propagation speeds were in excess of 500 m/day (all over peat > 2m deep). Fires were found to occur most often in concessions that contained drainage infrastructure but were not cleared prior to the fire season. Benefits of implementing this sensor system to improve current fire management techniques are discussed. Near real-time fire detection together with enhanced fire behavior monitoring capabilities would not only improve firefighting efforts, but also benefit analysis of fire impact on tropical peatlands, greenhouse gas emission estimations as well as mitigation measures to reduce severe fire events in the future.

Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain.

Science.gov (United States)

Huang, Jianying; Yang, Yang; Dib-Hajj, Sulayman D; van Es, Michael; Zhao, Peng; Salomon, Jody; Drenth, Joost P H; Waxman, Stephen G

2014-09-10

Sodium channel Nav1.7, encoded by SCN9A, is expressed in DRG neurons and regulates their excitability. Genetic and functional studies have established a critical contribution of Nav1.7 to human pain disorders. We have now characterized a novel Nav1.7 mutation (R1279P) from a female human subject with distal limb pain, in which depolarized fast inactivation overrides impaired activation to produce hyperexcitability and spontaneous firing in DRG neurons. Whole-cell voltage-clamp recordings in human embryonic kidney (HEK) 293 cells demonstrated that R1279P significantly depolarizes steady-state fast-, slow-, and closed-state inactivation. It accelerates deactivation, decelerates inactivation, and facilitates repriming. The mutation increases ramp currents in response to slow depolarizations. Our voltage-clamp analysis showed that R1279P depolarizes channel activation, a change that was supported by our multistate structural modeling. Because this mutation confers both gain-of-function and loss-of-function attributes on the Nav1.7 channel, we tested the impact of R1279P expression on DRG neuron excitability. Current-clamp studies reveal that R1279P depolarizes resting membrane potential, decreases current threshold, and increases firing frequency of evoked action potentials within small DRG neurons. The populations of spontaneously firing and repetitively firing neurons were increased by expressing R1279P. These observations indicate that the dominant proexcitatory gating changes associated with this mutation, including depolarized steady-state fast-, slow-, and closed-state inactivation, faster repriming, and larger ramp currents, override the depolarizing shift of activation, to produce hyperexcitability and spontaneous firing of nociceptive neurons that underlie pain. Copyright © 2014 the authors 0270-6474/14/3412328-13$15.00/0.

Direct estimation of diffuse gaseous emissions from coal fires: current methods and future directions

Science.gov (United States)

Engle, Mark A.; Olea, Ricardo A.; O'Keefe, Jennifer M. K.; Hower, James C.; Geboy, Nicholas J.

2013-01-01

Coal fires occur in nature spontaneously, contribute to increases in greenhouse gases, and emit atmospheric toxicants. Increasing interest in quantifying coal fire emissions has resulted in the adaptation and development of specialized approaches and adoption of numerical modeling techniques. Overview of these methods for direct estimation of diffuse gas emissions from coal fires is presented in this paper. Here we take advantage of stochastic Gaussian simulation to interpolate CO2 fluxes measured using a dynamic closed chamber at the Ruth Mullins coal fire in Perry County, Kentucky. This approach allows for preparing a map of diffuse gas emissions, one of the two primary ways that gases emanate from coal fires, and establishing the reliability of the study both locally and for the entire fire. Future research directions include continuous and automated sampling to improve quantification of gaseous coal fire emissions.

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells.

Science.gov (United States)

Sirenko, Syevda G; Yang, Dongmei; Maltseva, Larissa A; Kim, Mary S; Lakatta, Edward G; Maltsev, Victor A

2017-01-01

Uptake and release calcium from the sarcoplasmic reticulum (SR) (dubbed "calcium clock"), in the form of spontaneous, rhythmic, local diastolic calcium releases (LCRs), together with voltage-sensitive ion channels (membrane clock) form a coupled system that regulates the action potential (AP) firing rate. LCRs activate Sodium/Calcium exchanger (NCX) that accelerates diastolic depolarization and thus participating in regulation of the time at which the next AP will occur. Previous studies in rabbit SA node cells (SANC) demonstrated that the basal AP cycle length (APCL) is tightly coupled to the basal LCR period (time from the prior AP-induced Ca2+ transient to the diastolic LCR occurrence), and that this coupling is further modulated by autonomic receptor stimulation. Although spontaneous LCRs during diastolic depolarization have been reported in SANC of various species (rabbit, cat, mouse, toad), prior studies have failed to detect LCRs in spontaneously beating SANC of guinea-pig, a species that has been traditionally used in studies of cardiac pacemaker cell function. We performed a detailed investigation of whether guinea-pig SANC generate LCRs and whether they play a similar key role in regulation of the AP firing rate. We used two different approaches, 2D high-speed camera and classical line-scan confocal imaging. Positioning the scan-line beneath sarcolemma, parallel to the long axis of the cell, we found that rhythmically beating guinea-pig SANC do, indeed, generate spontaneous, diastolic LCRs beneath the surface membrane. The average key LCR characteristics measured in confocal images in guinea-pig SANC were comparable to rabbit SANC, both in the basal state and in the presence of β-adrenergic receptor stimulation. Moreover, the relationship between the LCR period and APCL was subtended by the same linear function. Thus, LCRs in guinea-pig SANC contribute to the diastolic depolarization and APCL regulation. Our findings indicate that coupled-clock system

Detection and delineation of coal mine fire in Jharia coal field (JCF ...

Indian Academy of Sciences (India)

71

Africa, Indonesia, Poland (Zhang et al. 2005; Kuenzer et al. .... is about 8 Km in west direction from Dhanbad Rrailway station. The location of the ...... International conference on Spontaneous coal seam fires: Mitigating a global. 543 disaster at ...

To Take the Stairs or Not to Take the Stairs? Employing the Reflective–Impulsive Model to Predict Spontaneous Physical Activity

Directory of Open Access Journals (Sweden)

Marcos Daou

2017-09-01

Full Text Available The reflective–impulsive model (RIM has been employed to explain various health behaviors. The present study used RIM to predict a spontaneous physical activity behavior. Specifically, 107 participants (75 females; Mage = 20.6 years, SD = 1.92 years completed measures of (1 reflections about spontaneous physical activity, as indexed by self-report questionnaire; (2 impulse toward physical activity, as indexed by the manikin task; and (3 (state self-control, as indexed by the Stroop task. The dependent variable was whether participants took the stairs or the elevator to the study laboratory. Results revealed reflections toward spontaneous physical activity positively predicted stair-taking. Further, a significant impulse toward physical activity × self-control interaction was observed. This interaction revealed that participants with high self-control who had a high impulse toward PA were more likely to take the stairs than their counterparts with a low impulse toward PA, whereas the opposite was the case for participants with low self-control. However, the impulse × self-control interaction was not significant when employing a self-report measure of trait self-control. Thus, RIM may be a good framework with which to consider spontaneous physical activity, but careful consideration must be given when examining variables within RIM (e.g., the boundary condition of self-control.

Fire protection for launch facilities using machine vision fire detection

Science.gov (United States)

Schwartz, Douglas B.

1993-02-01

Fire protection of critical space assets, including launch and fueling facilities and manned flight hardware, demands automatic sensors for continuous monitoring, and in certain high-threat areas, fast-reacting automatic suppression systems. Perhaps the most essential characteristic for these fire detection and suppression systems is high reliability; in other words, fire detectors should alarm only on actual fires and not be falsely activated by extraneous sources. Existing types of fire detectors have been greatly improved in the past decade; however, fundamental limitations of their method of operation leaves open a significant possibility of false alarms and restricts their usefulness. At the Civil Engineering Laboratory at Tyndall Air Force Base in Florida, a new type of fire detector is under development which 'sees' a fire visually, like a human being, and makes a reliable decision based on known visual characteristics of flames. Hardware prototypes of the Machine Vision (MV) Fire Detection System have undergone live fire tests and demonstrated extremely high accuracy in discriminating actual fires from false alarm sources. In fact, this technology promises to virtually eliminate false activations. This detector could be used to monitor fueling facilities, launch towers, clean rooms, and other high-value and high-risk areas. Applications can extend to space station and in-flight shuttle operations as well; fiber optics and remote camera heads enable the system to see around obstructed areas and crew compartments. The capability of the technology to distinguish fires means that fire detection can be provided even during maintenance operations, such as welding.

Spontaneous high-frequency (10-80 Hz) oscillations during up states in the cerebral cortex in vitro.

Science.gov (United States)

Compte, Albert; Reig, Ramon; Descalzo, Vanessa F; Harvey, Michael A; Puccini, Gabriel D; Sanchez-Vives, Maria V

2008-12-17

High-frequency oscillations in cortical networks have been linked to a variety of cognitive and perceptual processes. They have also been recorded in small cortical slices in vitro, indicating that neuronal synchronization at these frequencies is generated in the local cortical circuit. However, in vitro experiments have hitherto necessitated exogenous pharmacological or electrical stimulation to generate robust synchronized activity in the beta/gamma range. Here, we demonstrate that the isolated cortical microcircuitry generates beta and gamma oscillations spontaneously in the absence of externally applied neuromodulators or synaptic agonists. We show this in a spontaneously active slice preparation that engages in slow oscillatory activity similar to activity during slow-wave sleep. beta and gamma synchronization appeared during the up states of the slow oscillation. Simultaneous intracellular and extracellular recordings revealed synchronization between the timing of incoming synaptic events and population activity. This rhythm was mechanistically similar to pharmacologically induced gamma rhythms, as it also included sparse, irregular firing of neurons within the population oscillation, predominant involvement of inhibitory neurons, and a decrease of oscillation frequency after barbiturate application. Finally, we show in a computer model how a synaptic loop between excitatory and inhibitory neurons can explain the emergence of both the slow (network. We therefore conclude that oscillations in the beta/gamma range that share mechanisms with activity reported in vivo or in pharmacologically activated in vitro preparations can be generated during slow oscillatory activity in the local cortical circuit, even without exogenous pharmacological or electrical stimulation.

Control technique of spontaneous combustion in fully mechan ized stope during period of end caving under complex mining influence

Science.gov (United States)

Yuan, Benqing

2018-01-01

In view of the phenomenon of spontaneous combustion of coal seam occurring during the period of end caving under complex mining conditions, taking the 1116 (3) stope of Guqiao mine as the object of study, the causes of spontaneous combustion during the period of end caving are analyzed, according to the specific geological conditions of the stope to develop corresponding fire prevention measures, including the reduction of air supply and air leakage in goaf, reduce the amount of coal left, reasonable drainage, nitrogen injection for spontaneous combustion prevention, grouting for spontaneous combustion prevention and permanent closure, fundamentally eliminates the potential for spontaneous combustion during the period of 1116(3) stope end caving. The engineering practice shows that this kind of measure has reference value for the prevention and control of spontaneous combustion during the period of stope end caving.

Soil Microbial Activity Responses to Fire in a Semi-arid Savannah Ecosystem Pre- and Post-Monsoon Season

Science.gov (United States)

Jimenez, J. R.; Raub, H. D.; Jong, E. L.; Muscarella, C. R.; Smith, W. K.; Gallery, R. E.

2017-12-01

Extracellular enzyme activities (EEA) of soil microorganisms can act as important proxies for nutrient limitation and turnover in soil and provide insight into the biochemical requirements of microbes in terrestrial ecosystems. In semi-arid ecosystems, microbial activity is influenced by topography, disturbances such as fire, and seasonality from monsoon rains. Previous studies from forest ecosystems show that microbial communities shift to similar compositions after severe fires despite different initial conditions. In semi-arid ecosystems with high spatial heterogeniety, we ask does fire lead to patch intensification or patch homogenization and how do monsoon rains influence the successional trajectories of microbial responses? We analyzed microbial activity and soil biogeochemistry throughout the monsoon season in paired burned and unburned sites in the Santa Rita Experimental Range, AZ. Surface soil (5cm) from bare-ground patches, bole, canopy drip line, and nearby grass patches for 5 mesquite trees per site allowed tests of spatiotemporal responses to fire and monsoon rain. Microbial activity was low during the pre-monsoon season and did not differ between the burned and unburned sites. We found greater activity near mesquite trees that reflects soil water and nutrient availability. Fire increased soil alkalinity, though soils near mesquite trees were less affected. Soil water content was significantly higher in the burned sites post-monsoon, potentially reflecting greater hydrophobicity of burned soils. Considering the effects of fire in these semi-arid ecosystems is especially important in the context of the projected changing climate regime in this region. Assessing microbial community recovery pre-, during, and post-monsoon is important for testing predictions about whether successional pathways post-fire lead to recovery or novel trajectories of communities and ecosystem function.

Spontaneous activity in the developing mammalian retina: Form and function

Science.gov (United States)

Butts, Daniel Allison

Spontaneous neuronal activity is present in the immature mammalian retina during the initial stages of visual system development, before the retina is responsive to light. This activity consists of bursts of action potentials fired by retinal ganglion cells, and propagates in a wavelike manner across the inner plexiform layer of the retina. Unlike waves in other neural systems, retinal waves have large variability in both their rate and direction of propagation, and individual waves only propagate across small regions of the retina. The unique properties of retinal activity arise from dynamic processes within the developing retina, and produce characteristic spatiotemporal properties. These spatiotemporal properties are of particular interest, since they are believed to play a role in visual system development. This dissertation addresses the complex spatiotemporal patterning of the retinal waves from two different perspectives. First, it proposes how the immature circuitry of the developing retina generates these patterns of activity. In order to reproduce the distinct spatiotemporal properties observed in experiments, a model of the immature retinal circuitry must meet certain requirements, which are satisfied by a coarse-grained model of the developing retina that we propose. Second, this dissertation addresses how the particular spatiotemporal patterning of the retinal waves provides information to the rest of the visual system and, as a result, can be used to guide visual system development. By measuring the properties of this information, we place constraints on the developmental mechanisms that use this activity, and show how the particular spatiotemporal properties of the retinal waves provide this information. Together, this dissertation demonstrates how the apparent complexity of retinal wave patterning can be understood both through the immature circuitry that generates it, and through the developmental mechanisms that may use it. The first three

[Effects of reversing the feeding cycle and the light period on the spontaneous activity of the rat (author's transl)].

Science.gov (United States)

Ticca, M

1976-01-01

The amount and the circadian distribution of spontaneous activity in the rat are influenced by a number of factors, whose importance and interrelationships are still deeply discussed. In order to check the reliability of previous studies about the effects of meal-eating on the spontaneous activity (wheel running) of rats of our Sprague-Dawley strain, the adjustment to the modifications of the normal day-night cycle and of the normal nocturnal feeding rhythm have been controlled. Reversing the normal light and dark periods caused the rats, after a 24 hours period, to lower and to irregularly distribute their spontaneous activity. Rats shifted their pattern of maximal activity by 12 hours in the new period of darkness in about five days, and showed to have completely fixed the new reversed running habit. Also feeding habits changed in a similar way, but more slowly. The levels of mean daily activity did not change. In a second experiment, rats, received food during light hours, and were deprived during dark hours. Their activity increased considerably and irregularly during dark hours, while a very slight rise of wheel running was shown during light hours. Body weight gain and food consumption were similar to those of the control group. These results slightly differ from those obtained using other rat strains, and are an interesting example of reinforcement of a spontaneous behavior resulting more from the light-dark cycle than from cues provided by food deprivation.

Fire activity and hydrological dynamics in the past 5700 years reconstructed from Sphagnum peatlands along the oceanic-continental climatic gradient in northern Poland

Science.gov (United States)

Marcisz, Katarzyna; Gałka, Mariusz; Pietrala, Patryk; Miotk-Szpiganowicz, Grażyna; Obremska, Milena; Tobolski, Kazimierz; Lamentowicz, Mariusz

2017-12-01

Fire is a critical component of many ecosystems and, as predicted by various climate models, fire activity may increase significantly in the following years due to climate change. Therefore, knowledge about the past fire activity of various ecosystems is highly important for future nature conservation purposes. We present results of high-resolution investigation of fire activity and hydrological changes in northern Poland. We analyzed microscopic charcoal from three Sphagnum-dominated peatlands located on the south of Baltic, on the oceanic-continental (west-east) climatic gradient, and reconstructed the history of fire in the last 5700 years. We hypothesize that air circulation patterns are highly important for local fire activity, and that fire activity is more intensive in peatlands influenced by continental air masses. We have found out that forest fires have been occurring regularly since the past millennia and were linked to climatic conditions. We show that fire activity (related to climate and fuel availability) was significantly higher in sites dominated by continental climate (northeastern Poland) than in the site located under oceanic conditions (northwestern Poland)-microscopic charcoal influx was 13.3 times higher in the eastern study site of the gradient, compared to the western study site. Recorded fire activity patterns were different between the sites in a long timescale. Moreover, most of the recorded charcoal peaks occurred during high water tables. Rising human pressure has caused droughts and water table instability, and substantial increase in fire activity in the last 400 years.

Detection and Characterization of Low Temperature Peat Fires during the 2015 Fire Catastrophe in Indonesia Using a New High-Sensitivity Fire Monitoring Satellite Sensor (FireBird)

Science.gov (United States)

Atwood, Elizabeth C.; Englhart, Sandra; Lorenz, Eckehard; Halle, Winfried; Wiedemann, Werner; Siegert, Florian

2016-01-01

Vast and disastrous fires occurred on Borneo during the 2015 dry season, pushing Indonesia into the top five carbon emitting countries. The region was affected by a very strong El Niño-Southern Oscillation (ENSO) climate phenomenon, on par with the last severe event in 1997/98. Fire dynamics in Central Kalimantan were investigated using an innovative sensor offering higher sensitivity to a wider range of fire intensities at a finer spatial resolution (160 m) than heretofore available. The sensor is onboard the TET-1 satellite, part of the German Aerospace Center (DLR) FireBird mission. TET-1 images (acquired every 2–3 days) from the middle infrared were used to detect fires continuously burning for almost three weeks in the protected peatlands of Sebangau National Park as well as surrounding areas with active logging and oil palm concessions. TET-1 detection capabilities were compared with MODIS active fire detection and Landsat burned area algorithms. Fire dynamics, including fire front propagation speed and area burned, were investigated. We show that TET-1 has improved detection capabilities over MODIS in monitoring low-intensity peatland fire fronts through thick smoke and haze. Analysis of fire dynamics revealed that the largest burned areas resulted from fire front lines started from multiple locations, and the highest propagation speeds were in excess of 500 m/day (all over peat > 2m deep). Fires were found to occur most often in concessions that contained drainage infrastructure but were not cleared prior to the fire season. Benefits of implementing this sensor system to improve current fire management techniques are discussed. Near real-time fire detection together with enhanced fire behavior monitoring capabilities would not only improve firefighting efforts, but also benefit analysis of fire impact on tropical peatlands, greenhouse gas emission estimations as well as mitigation measures to reduce severe fire events in the future. PMID:27486664

Phase-locking of bursting neuronal firing to dominant LFP frequency components.

Science.gov (United States)

Constantinou, Maria; Elijah, Daniel H; Squirrell, Daniel; Gigg, John; Montemurro, Marcelo A

2015-10-01

Neuronal firing in the hippocampal formation relative to the phase of local field potentials (LFP) has a key role in memory processing and spatial navigation. Firing can be in either tonic or burst mode. Although bursting neurons are common in the hippocampal formation, the characteristics of their locking to LFP phase are not completely understood. We investigated phase-locking properties of bursting neurons using simulations generated by a dual compartmental model of a pyramidal neuron adapted to match the bursting activity in the subiculum of a rat. The model was driven with stochastic input signals containing a power spectral profile consistent with physiologically relevant frequencies observed in LFP. The single spikes and spike bursts fired by the model were locked to a preferred phase of the predominant frequency band where there was a peak in the power of the driving signal. Moreover, the preferred phase of locking shifted with increasing burst size, providing evidence that LFP phase can be encoded by burst size. We also provide initial support for the model results by analysing example data of spontaneous LFP and spiking activity recorded from the subiculum of a single urethane-anaesthetised rat. Subicular neurons fired single spikes, two-spike bursts and larger bursts that locked to a preferred phase of either dominant slow oscillations or theta rhythms within the LFP, according to the model prediction. Both power-modulated phase-locking and gradual shift in the preferred phase of locking as a function of burst size suggest that neurons can use bursts to encode timing information contained in LFP phase into a spike-count code. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Spontaneous membrane formation and self-encapsulation of active rods in an inhomogeneous motility field

NARCIS (Netherlands)

Grauer, J.; Löwen, H.; Janssen, L.M.C.

2018-01-01

We study the collective dynamics of self-propelled rods in an inhomogeneous motility field. At the interface between two regions of constant but different motility, a smectic rod layer is spontaneously created through aligning interactions between the active rods, reminiscent of an artificial,

Combined use of weather forecasting and satellite remote sensing information for fire risk, fire and fire impact monitoring

Directory of Open Access Journals (Sweden)

Wolfgang Knorr

2011-06-01

Full Text Available The restoration of fire-affected forest areas needs to be combined with their future protection from renewed catastrophic fires, such as those that occurred in Greece during the 2007 summer season. The present work demonstrates that the use of various sources of satellite data in conjunction with weather forecast information is capable of providing valuable information for the characterization of fire danger with the purpose of protecting the Greek national forest areas. This study shows that favourable meteorological conditions have contributed to the fire outbreak during the days of the unusually damaging fires in Peloponnese as well as Euboia (modern Greek: Evia at the end of August 2007. During those days, Greece was located between an extended high pressure system in Central Europe and a low pressure system in the Middle East. Their combination resulted in strong north-northeasterly winds in the Aegean Sea. As a consequence, strong winds were also observed in the regions of Evia and Peloponnese, especially in mountainous areas. The analysis of satellite images showing smoke emitted from the fires corroborates the results from the weather forecasts. A further analysis using the Fraction of Absorbed Photosyntetically Active Radiation (FAPAR as an indicator of active vegetation shows the extent of the destruction caused by the fire. The position of the burned areas coincides with that of the active fires detected in the earlier satellite image. Using the annual maximum FAPAR as an indicator of regional vegetation density, it was found that only regions with relatively high FAPAR were burned.

Spontaneous Ca2+ transients in interstitial cells of Cajal located within the deep muscular plexus of the murine small intestine

Science.gov (United States)

Baker, Salah A.; Drumm, Bernard T.; Saur, Dieter; Hennig, Grant W.; Ward, Sean M.

2016-01-01

Key points Interstitial cells of Cajal at the level of the deep muscular plexus (ICC‐DMP) in the small intestine generate spontaneous Ca2+ transients that consist of localized Ca2+ events and limited propagating Ca2+ waves.Ca2+ transients in ICC‐DMP display variable characteristics: from discrete, highly localized Ca2+ transients to regionalized Ca2+ waves with variable rates of occurrence, amplitude, duration and spatial spread.Ca2+ transients fired stochastically, with no cellular or multicellular rhythmic activity being observed. No correlation was found between the firing sites in adjacent cells.Ca2+ transients in ICC‐DMP are suppressed by the ongoing release of inhibitory neurotransmitter(s).Functional intracellular Ca2+ stores are essential for spontaneous Ca2+ transients, and the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) pump is necessary for maintenance of spontaneity.Ca2+ release mechanisms involve both ryanodine receptors (RyRs) and inositol triphosphate receptors (InsP3Rs). Release from these channels is interdependent.ICC express transcripts of multiple RyRs and InsP3Rs, with Itpr1 and Ryr2 subtypes displaying the highest expression. Abstract Interstitial cells of Cajal in the deep muscular plexus of the small intestine (ICC‐DMP) are closely associated with varicosities of enteric motor neurons and generate responses contributing to neural regulation of intestinal motility. Responses of ICC‐DMP are mediated by activation of Ca2+‐activated Cl− channels; thus, Ca2+ signalling is central to the behaviours of these cells. Confocal imaging was used to characterize the nature and mechanisms of Ca2+ transients in ICC‐DMP within intact jejunal muscles expressing a genetically encoded Ca2+ indicator (GCaMP3) selectively in ICC. ICC‐DMP displayed spontaneous Ca2+ transients that ranged from discrete, localized events to waves that propagated over variable distances. The occurrence of Ca2+ transients was highly variable, and it was

Spontaneous Ca(2+) transients in interstitial cells of Cajal located within the deep muscular plexus of the murine small intestine.

Science.gov (United States)

Baker, Salah A; Drumm, Bernard T; Saur, Dieter; Hennig, Grant W; Ward, Sean M; Sanders, Kenton M

2016-06-15

Interstitial cells of Cajal at the level of the deep muscular plexus (ICC-DMP) in the small intestine generate spontaneous Ca(2+) transients that consist of localized Ca(2+) events and limited propagating Ca(2+) waves. Ca(2+) transients in ICC-DMP display variable characteristics: from discrete, highly localized Ca(2+) transients to regionalized Ca(2+) waves with variable rates of occurrence, amplitude, duration and spatial spread. Ca(2+) transients fired stochastically, with no cellular or multicellular rhythmic activity being observed. No correlation was found between the firing sites in adjacent cells. Ca(2+) transients in ICC-DMP are suppressed by the ongoing release of inhibitory neurotransmitter(s). Functional intracellular Ca(2+) stores are essential for spontaneous Ca(2+) transients, and the sarco/endoplasmic reticulum Ca(2+) -ATPase (SERCA) pump is necessary for maintenance of spontaneity. Ca(2+) release mechanisms involve both ryanodine receptors (RyRs) and inositol triphosphate receptors (InsP3 Rs). Release from these channels is interdependent. ICC express transcripts of multiple RyRs and InsP3 Rs, with Itpr1 and Ryr2 subtypes displaying the highest expression. Interstitial cells of Cajal in the deep muscular plexus of the small intestine (ICC-DMP) are closely associated with varicosities of enteric motor neurons and generate responses contributing to neural regulation of intestinal motility. Responses of ICC-DMP are mediated by activation of Ca(2+) -activated Cl(-) channels; thus, Ca(2+) signalling is central to the behaviours of these cells. Confocal imaging was used to characterize the nature and mechanisms of Ca(2+) transients in ICC-DMP within intact jejunal muscles expressing a genetically encoded Ca(2+) indicator (GCaMP3) selectively in ICC. ICC-DMP displayed spontaneous Ca(2+) transients that ranged from discrete, localized events to waves that propagated over variable distances. The occurrence of Ca(2+) transients was highly variable, and it

General theory for spontaneous emission in active dielectric microstructures: Example of a fiber amplifier

DEFF Research Database (Denmark)

Søndergaard, Thomas; Tromborg, Bjarne

2001-01-01

A model for spontaneous emission in active dielectric microstructures is given in terms of the classical electric field Green's tensor and the quantum-mechanical operators for the generating currents. A formalism is given for calculating the Green's tensor, which does not rely on the existence...

Estradiol-Dependent Stimulation and Suppression of Gonadotropin-Releasing Hormone Neuron Firing Activity by Corticotropin-Releasing Hormone in Female Mice.

Science.gov (United States)

Phumsatitpong, Chayarndorn; Moenter, Suzanne M

2018-01-01

Gonadotropin-releasing hormone (GnRH) neurons are the final central regulators of reproduction, integrating various inputs that modulate fertility. Stress typically inhibits reproduction but can be stimulatory; stress effects can also be modulated by steroid milieu. Corticotropin-releasing hormone (CRH) released during the stress response may suppress reproduction independent of downstream glucocorticoids. We hypothesized CRH suppresses fertility by decreasing GnRH neuron firing activity. To test this, mice were ovariectomized (OVX) and either implanted with an estradiol capsule (OVX+E) or not treated further to examine the influence of estradiol on GnRH neuron response to CRH. Targeted extracellular recordings were used to record firing activity from green fluorescent protein-identified GnRH neurons in brain slices before and during CRH treatment; recordings were done in the afternoon when estradiol has a positive feedback effect to increase GnRH neuron firing. In OVX mice, CRH did not affect the firing rate of GnRH neurons. In contrast, CRH exhibited dose-dependent stimulatory (30 nM) or inhibitory (100 nM) effects on GnRH neuron firing activity in OVX+E mice; both effects were reversible. The dose-dependent effects of CRH appear to result from activation of different receptor populations; a CRH receptor type-1 agonist increased firing activity in GnRH neurons, whereas a CRH receptor type-2 agonist decreased firing activity. CRH and specific agonists also differentially regulated short-term burst frequency and burst properties, including burst duration, spikes/burst, and/or intraburst interval. These results indicate that CRH alters GnRH neuron activity and that estradiol is required for CRH to exert both stimulatory and inhibitory effects on GnRH neurons. Copyright © 2018 Endocrine Society.

Effects of Lightning and Other Meteorological Factors on Fire Activity in the North American Boreal Forest: Implications for Fire Weather Forecasting

Science.gov (United States)

Peterson, D.; Wang, J.; Ichoku, C.; Remer, L. A.

2010-01-01

The effects of lightning and other meteorological factors on wildfire activity in the North American boreal forest are statistically analyzed during the fire seasons of 2000-2006 through an integration of the following data sets: the MODerate Resolution Imaging Spectroradiometer (MODIS) level 2 fire products, the 3-hourly 32-kin gridded meteorological data from North American Regional Reanalysis (NARR), and the lightning data collected by the Canadian Lightning Detection Network (CLDN) and the Alaska Lightning Detection Network (ALDN). Positive anomalies of the 500 hPa geopotential height field, convective available potential energy (CAPE), number of cloud-to-ground lightning strikes, and the number of consecutive dry days are found to be statistically important to the seasonal variation of MODIS fire counts in a large portion of Canada and the entirety of Alaska. Analysis of fire occurrence patterns in the eastern and western boreal forest regions shows that dry (in the absence of precipitation) lightning strikes account for only 20% of the total lightning strikes, but are associated with (and likely cause) 40% of the MODIS observed fire counts in these regions. The chance for ignition increases when a threshold of at least 10 dry strikes per NARR grid box and at least 10 consecutive dry days is reached. Due to the orientation of the large-scale pattern, complex differences in fire and lightning occurrence and variability were also found between the eastern and western sub-regions. Locations with a high percentage of dry strikes commonly experience an increased number of fire counts, but the mean number of fire counts per dry strike is more than 50% higher in western boreal forest sub-region, suggesting a geographic and possible topographic influence. While wet lightning events are found to occur with a large range of CAPE values, a high probability for dry lightning occurs only when 500 hPa geopotential heights are above 5700m and CAPE values are near the maximum

The Joint Fire Science Program Fire Exchange Network: Facilitating Knowledge Exchange About Wildland Fire Science Across the U.S.

Science.gov (United States)

York, A.; Blocksome, C.; Cheng, T.; Creighton, J.; Edwards, G.; Frederick, S.; Giardina, C. P.; Goebel, P. C.; Gucker, C.; Kobziar, L.; Lane, E.; Leis, S.; Long, A.; Maier, C.; Marschall, J.; McGowan-Stinski, J.; Mohr, H.; MontBlanc, E.; Pellant, M.; Pickett, E.; Seesholtz, D.; Skowronski, N.; Stambaugh, M. C.; Stephens, S.; Thode, A.; Trainor, S. F.; Waldrop, T.; Wolfson, B.; Wright, V.; Zedler, P.

2014-12-01

The Joint Fire Science Program's (JFSP) Fire Exchange Network is actively working to accelerate the awareness, understanding, and adoption of wildland fire science information by federal, tribal, state, local, and private stakeholders within ecologically similar regions. Our network of 15 regional exchanges provides timely, accurate, and regionally relevant science-based information to assist with fire management challenges. Regional activities, through which we engage fire and resource managers, scientists, and private landowners, include online newsletters and announcements, social media, regionally focused web-based clearinghouses of relevant science, field trips and demonstration sites, workshops and conferences, webinars and online training, and syntheses and fact sheets. Exchanges also help investigators design research that is relevant to regional management needs and assist with technology transfer to management audiences. This poster provides an introduction to and map of the regional exchanges.

Brain activity for spontaneous and explicit mentalizing in adults with autism spectrum disorder: An fMRI study

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Annabel D. Nijhof

Full Text Available The socio-communicative difficulties of individuals with autism spectrum disorder (ASD are hypothesized to be caused by a specific deficit in the ability to represent one's own and others' mental states, referred to as Theory of Mind or mentalizing. However, many individuals with ASD show successful performance on explicit measures of mentalizing, and for this reason, the deficit is thought to be better captured by measures of spontaneous mentalizing. While there is initial behavioral support for this hypothesis, spontaneous mentalizing in ASD has not yet been studied at the neural level. Recent findings indicate involvement of the right temporoparietal junction (rTPJ in both explicit and spontaneous mentalizing (Bardi et al., 2016. In the current study, we investigated brain activation during explicit and spontaneous mentalizing in adults with ASD by means of fMRI. Based on our hypothesis of a core mentalizing deficit in ASD, decreased rTPJ activity was expected for both forms of mentalizing. A group of 24 adults with ASD and 21 neurotypical controls carried out a spontaneous and an explicit version of the same mentalizing task. They watched videos in which both they themselves and another agent formed a belief about the location of an object (belief formation phase. Only in the explicit task version participants were instructed to report the agent's belief on some trials. At the behavioral level, no group differences were revealed in either of the task versions. A planned region-of-interest analysis of the rTPJ showed that this region was more active for false- than for true-belief formation, independent of task version, especially when the agent's belief had a positive content (when the agent was expecting the object. This effect of belief was absent in adults with ASD. A whole-brain analysis revealed reduced activation in the anterior middle temporal pole in ASD for false - versus true-belief trials, independent of task version. Our findings

Spontaneous Activity Associated with Delusions of Schizophrenia in the Left Medial Superior Frontal Gyrus: A Resting-State fMRI Study.

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Bin Gao

Full Text Available Delusions of schizophrenia have been found to be associated with alterations of some brain regions in structure and task-induced activation. However, the relationship between spontaneously occurring symptoms and spontaneous brain activity remains unclear. In the current study, 14 schizophrenic patients with delusions and 14 healthy controls underwent a resting-state functional magnetic resonance imaging (RS-fMRI scan. Patients with delusions of schizophrenia patients were rated with Positive and Negative Syndrome Scale (PANSS and Characteristics of Delusional Rating Scale (CDRS. Regional homogeneity (ReHo was calculated to measure the local synchronization of the spontaneous activity in a voxel-wise way. A two-sample t-test showed that ReHo of the right anterior cingulate gyrus and left medial superior frontal gyrus were higher in patients, and ReHo of the left superior occipital gyrus was lower, compared to healthy controls. Further, among patients, correlation analysis showed a significant difference between delusion scores of CRDS and ReHo of brain regions. ReHo of the left medial superior frontal gyrus was negatively correlated with patients' CDRS scores but not with delusional PANSS scores. These results suggested that altered local synchronization of spontaneous brain activity may be related to the pathophysiology of delusion in schizophrenia.

Spontaneous Activity Associated with Delusions of Schizophrenia in the Left Medial Superior Frontal Gyrus: A Resting-State fMRI Study.

Science.gov (United States)

Gao, Bin; Wang, Yiquan; Liu, Weibo; Chen, Zhiyu; Zhou, Heshan; Yang, Jinyu; Cohen, Zachary; Zhu, Yihong; Zang, Yufeng

2015-01-01

Delusions of schizophrenia have been found to be associated with alterations of some brain regions in structure and task-induced activation. However, the relationship between spontaneously occurring symptoms and spontaneous brain activity remains unclear. In the current study, 14 schizophrenic patients with delusions and 14 healthy controls underwent a resting-state functional magnetic resonance imaging (RS-fMRI) scan. Patients with delusions of schizophrenia patients were rated with Positive and Negative Syndrome Scale (PANSS) and Characteristics of Delusional Rating Scale (CDRS). Regional homogeneity (ReHo) was calculated to measure the local synchronization of the spontaneous activity in a voxel-wise way. A two-sample t-test showed that ReHo of the right anterior cingulate gyrus and left medial superior frontal gyrus were higher in patients, and ReHo of the left superior occipital gyrus was lower, compared to healthy controls. Further, among patients, correlation analysis showed a significant difference between delusion scores of CRDS and ReHo of brain regions. ReHo of the left medial superior frontal gyrus was negatively correlated with patients' CDRS scores but not with delusional PANSS scores. These results suggested that altered local synchronization of spontaneous brain activity may be related to the pathophysiology of delusion in schizophrenia.

Spontaneous neuronal activity as a self-organized critical phenomenon

Science.gov (United States)

de Arcangelis, L.; Herrmann, H. J.

2013-01-01

Neuronal avalanches are a novel mode of activity in neuronal networks, experimentally found in vitro and in vivo, and exhibit a robust critical behaviour. Avalanche activity can be modelled within the self-organized criticality framework, including threshold firing, refractory period and activity-dependent synaptic plasticity. The size and duration distributions confirm that the system acts in a critical state, whose scaling behaviour is very robust. Next, we discuss the temporal organization of neuronal avalanches. This is given by the alternation between states of high and low activity, named up and down states, leading to a balance between excitation and inhibition controlled by a single parameter. During these periods both the single neuron state and the network excitability level, keeping memory of past activity, are tuned by homeostatic mechanisms. Finally, we verify if a system with no characteristic response can ever learn in a controlled and reproducible way. Learning in the model occurs via plastic adaptation of synaptic strengths by a non-uniform negative feedback mechanism. Learning is a truly collective process and the learning dynamics exhibits universal features. Even complex rules can be learned provided that the plastic adaptation is sufficiently slow.

Characteristic effects of stochastic oscillatory forcing on neural firing: analytical theory and comparison to paddlefish electroreceptor data.

Science.gov (United States)

Bauermeister, Christoph; Schwalger, Tilo; Russell, David F; Neiman, Alexander B; Lindner, Benjamin

2013-01-01

Stochastic signals with pronounced oscillatory components are frequently encountered in neural systems. Input currents to a neuron in the form of stochastic oscillations could be of exogenous origin, e.g. sensory input or synaptic input from a network rhythm. They shape spike firing statistics in a characteristic way, which we explore theoretically in this report. We consider a perfect integrate-and-fire neuron that is stimulated by a constant base current (to drive regular spontaneous firing), along with Gaussian narrow-band noise (a simple example of stochastic oscillations), and a broadband noise. We derive expressions for the nth-order interval distribution, its variance, and the serial correlation coefficients of the interspike intervals (ISIs) and confirm these analytical results by computer simulations. The theory is then applied to experimental data from electroreceptors of paddlefish, which have two distinct types of internal noisy oscillators, one forcing the other. The theory provides an analytical description of their afferent spiking statistics during spontaneous firing, and replicates a pronounced dependence of ISI serial correlation coefficients on the relative frequency of the driving oscillations, and furthermore allows extraction of certain parameters of the intrinsic oscillators embedded in these electroreceptors.

Fire as Technology

Science.gov (United States)

Rudolph, Robert N.

2011-01-01

In this article, the author describes a project that deals with fire production as an aspect of technology. The project challenges students to be survivors in a five-day classroom activity. Students research various materials and methods to produce fire without the use of matches or other modern combustion devices, then must create "fire" to keep…

Auditory Tones and Foot-Shock Recapitulate Spontaneous Sub-Threshold Activity in Basolateral Amygdala Principal Neurons and Interneurons.

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François Windels

Full Text Available In quiescent states such as anesthesia and slow wave sleep, cortical networks show slow rhythmic synchronized activity. In sensory cortices this rhythmic activity shows a stereotypical pattern that is recapitulated by stimulation of the appropriate sensory modality. The amygdala receives sensory input from a variety of sources, and in anesthetized animals, neurons in the basolateral amygdala (BLA show slow rhythmic synchronized activity. Extracellular field potential recordings show that these oscillations are synchronized with sensory cortex and the thalamus, with both the thalamus and cortex leading the BLA. Using whole-cell recording in vivo we show that the membrane potential of principal neurons spontaneously oscillates between up- and down-states. Footshock and auditory stimulation delivered during down-states evokes an up-state that fully recapitulates those occurring spontaneously. These results suggest that neurons in the BLA receive convergent input from networks of cortical neurons with slow oscillatory activity and that somatosensory and auditory stimulation can trigger activity in these same networks.

Operating room fire prevention: creating an electrosurgical unit fire safety device.

Science.gov (United States)

Culp, William C; Kimbrough, Bradly A; Luna, Sarah; Maguddayao, Aris J

2014-08-01

To reduce the incidence of surgical fires. Operating room fires represent a potentially life-threatening hazard and are triggered by the electrosurgical unit (ESU) pencil. Carbon dioxide is a fire suppressant and is a routinely used medical gas. We hypothesize that a shroud of protective carbon dioxide covering the tip of the ESU pencil displaces oxygen, thereby preventing fire ignition. Using 3-dimensional modeling techniques, a polymer sleeve was created and attached to an ESU pencil. This sleeve was connected to a carbon dioxide source and directed the gas through multiple precisely angled ports, generating a cone of fire-suppressive carbon dioxide surrounding the active pencil tip. This device was evaluated in a flammability test chamber containing 21%, 50%, and 100% oxygen with sustained ESU activation. The sleeve was tested with and without carbon dioxide (control) until a fuel was ignited or 30 seconds elapsed. Time to ignition was measured by high-speed videography. Fires were ignited with each control trial (15/15 trials). The control group median ± SD ignition time in 21% oxygen was 3.0 ± 2.4 seconds, in 50% oxygen was 0.1 ± 1.8 seconds, and in 100% oxygen was 0.03 ± 0.1 seconds. No fire was observed when the fire safety device was used in all concentrations of oxygen (0/15 trials; P fire ignition was 76% to 100%. A sleeve creating a cone of protective carbon dioxide gas enshrouding the sparks from an ESU pencil effectively prevents fire in a high-flammability model. Clinical application of this device may reduce the incidence of operating room fires.

Determinants of fire activity during the last 3500 yr at a wildland-urban interface, Alberta, Canada

Science.gov (United States)

Davis, Emma L.; Courtney Mustaphi, Colin J.; Gall, Amber; Pisaric, Michael F. J.; Vermaire, Jesse C.; Moser, Katrina A.

2016-11-01

Long-term records of wildfires and their controlling factors are important sources of information for informing land management practices. Here, dendrochronology and lake sediment analyses are used to develop a 3500-yr fire and vegetation history for a montane forest in Jasper National Park, Alberta, Canada. The tree-ring record (AD 1771-2012) indicates that this region historically experienced a mixed-severity fire regime, and that effective fire suppression excluded widespread fire events from the study area during the 20th century. A sediment core collected from Little Trefoil Lake, located near the Jasper townsite, is analyzed for subfossil pollen and macroscopic charcoal (>150 μm). When comparing the tree-ring record to the 3500-yr record of sediment-derived fire events, only high-severity fires are represented in the charcoal record. Comparisons between the charcoal record and historical climate and pollen data indicate that climate and vegetation composition have been important controls on the fire regime for most of the last 3500 yr. Although fire frequency is presently within the historical range of variability, the fire return interval of the last 150 yr is longer than expected given modern climate and vegetation conditions, indicating that humans have become the main control on fire activity around Little Trefoil Lake.

Spontaneous Brain Activity Did Not Show the Effect of Violent Video Games on Aggression: A Resting-State fMRI Study

OpenAIRE

Wei Pan; Wei Pan; Wei Pan; Xuemei Gao; Shuo Shi; Fuqu Liu; Chao Li

2018-01-01

A great many of empirical researches have proved that longtime exposure to violent video game can lead to a series of negative effects. Although research has focused on the neural basis of the correlation between violent video game and aggression, little is known whether the spontaneous brain activity is associated with violent video game exposure. To address this question, we measured the spontaneous brain activity using resting-state functional magnetic resonance imaging (fMRI). We used the...

Quantifying Fire's Impacts on Total and Pyrogenic Carbon Stocks in Mixed-Conifer Forests: Results from Pre- and Post-Fire Measurements in Active Wildfire Incidents

Science.gov (United States)

Miesel, J. R.; Reiner, A. L.; Ewell, C. M.; Sanderman, J.; Maestrini, B.; Adkins, J.

2016-12-01

Widespread US fire suppression policy has contributed to an accumulation of vegetation in many western forests relative to historic conditions, and these changes can exacerbate wildfire severity and carbon (C) emissions. Serious concern exists about positive feedbacks between wildfire emissions and global climate; however, fires not only release C from terrestrial to atmospheric pools, they also create "black" or pyrogenic C (PyC) which contributes to longer-term C stability. Our objective was to quantify wildfire impacts on aboveground and belowground total C and PyC stocks in California mixed-conifer forests. We worked with incident management teams to access five active wildfires to establish and measure plots within days before and after fire. We measured pre- and post-fire aboveground forest structure and woody fuels to calculate aboveground biomass, biomass C, and PyC, and we collected pre- and post-fire forest floor and 0-5 cm mineral soil samples to measure belowground C and PyC stocks. Our preliminary results show that fire had minimal impact on the number of trees per hectare, whereas C losses from the tree layer occurred via consumption of foliage, and PyC gain occurred in tree bark. Fire released 54% to 100% of surface fuel C. In the forest floor layer, we observed 33 to 100% C loss, whereas changes in PyC stocks ranged from 100% loss to 186% gain relative to pre-fire samples. In general, fire had minimal to no impact on 0-5 cm mineral soil C. We will present relationships between total C, PyC and post-fire C and N dynamics in one of the five wildfire sites. Our data are unique because they represent nearly immediate pre- and post-fire measurements in major wildfires in a widespread western U.S. forest type. This research advances understanding of the role of fire on forest C fluxes and C sequestration potential as PyC.

Effect of a non lethal whole-body gamma irradiation on the spontaneous and evoked electroencephalographic activities of the adult rabbit

International Nuclear Information System (INIS)

Court, L.

1969-01-01

The whole of the experimental methods described (animal preparation, achievement of a precise physiological technique, dosimetry, biological information processing) allowed us to follow the changes for 15 days in the spontaneous and evoked electroencephalogram activities of rabbits submitted to a non-lethal 400 rads whole-body gamma-irradiation. Behavioural troubles, changes in the arousal state and the spontaneous electrical activity of the neo-cortex and hippocampus were noticed constantly together with an enhanced cortical excitability, and the appearance of elements of the paroxystic series sometimes in contrast with a general decrease in amplitude. After a visual stimulus the general morphology of evoked activities at the level of the primary visual areas and hippocampus was unchanged, but enhanced latencies and delays, less systematic modifications in amplitudes seemed to show out a direct effect of radiations on the nervous system and sensorial activities; these troubles seemed to occur independently from the basic electrical activity. As a whole, the changes observed were usually transitory and varied with each individual. Finally an assumption is made to explain the mechanism of arousal troubles and the general evolution of spontaneous electrical activity in the brain. (author) [fr

The relationship between particulate pollution levels in Australian cities, meteorology, and landscape fire activity detected from MODIS hotspots.

Science.gov (United States)

Price, Owen F; Williamson, Grant J; Henderson, Sarah B; Johnston, Fay; Bowman, David M J S

2012-01-01

Smoke from bushfires is an emerging issue for fire managers because of increasing evidence for its public health effects. Development of forecasting models to predict future pollution levels based on the relationship between bushfire activity and current pollution levels would be a useful management tool. As a first step, we use daily thermal anomalies detected by the MODIS Active Fire Product (referred to as "hotspots"), pollution concentrations, and meteorological data for the years 2002 to 2008, to examine the statistical relationship between fire activity in the landscapes and pollution levels around Perth and Sydney, two large Australian cities. Resultant models were statistically significant, but differed in their goodness of fit and the distance at which the strength of the relationship was strongest. For Sydney, a univariate model for hotspot activity within 100 km explained 24% of variation in pollution levels, and the best model including atmospheric variables explained 56% of variation. For Perth, the best radius was 400 km, explaining only 7% of variation, while the model including atmospheric variables explained 31% of the variation. Pollution was higher when the atmosphere was more stable and in the presence of on-shore winds, whereas there was no effect of wind blowing from the fires toward the pollution monitors. Our analysis shows there is a good prospect for developing region-specific forecasting tools combining hotspot fire activity with meteorological data.

Reconstruction of human brain spontaneous activity based on frequency-pattern analysis of magnetoencephalography data

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Rodolfo R Llinas

2015-10-01

Full Text Available A new method for the analysis and localization of brain activity has been developed, based on multichannel magnetic field recordings, over minutes, superimposed on the MRI of the individual. Here, a high resolution Fourier Transform is obtained over the entire recording period, leading to a detailed multi-frequency spectrum. Further analysis implements a total decomposition of the frequency components into functionally invariant entities, each having an invariant field pattern localizable in recording space. The method, addressed as functional tomography, makes it possible to find the distribution of magnetic field sources in space. Here, the method is applied to the analysis of simulated data, to oscillating signals activating a physical current dipoles phantom, and to recordings of spontaneous brain activity in ten healthy adults. In the analysis of simulated data, 61 dipoles are localized with 0.7 mm precision. Concerning the physical phantom the method is able to localize three simultaneously activated current dipoles with 1 mm precision. Spatial resolution 3 mm was attained when localizing spontaneous alpha rhythm activity in ten healthy adults, where the alpha peak was specified for each subject individually. Co-registration of the functional tomograms with each subject’s head MRI localized alpha range activity to the occipital and/or posterior parietal brain region. This is the first application of this new functional tomography to human brain activity. The method successfully provides an overall view of brain electrical activity, a detailed spectral description and, combined with MRI, the localization of sources in anatomical brain space.

Reconstruction of human brain spontaneous activity based on frequency-pattern analysis of magnetoencephalography data

Science.gov (United States)

Llinás, Rodolfo R.; Ustinin, Mikhail N.; Rykunov, Stanislav D.; Boyko, Anna I.; Sychev, Vyacheslav V.; Walton, Kerry D.; Rabello, Guilherme M.; Garcia, John

2015-01-01

A new method for the analysis and localization of brain activity has been developed, based on multichannel magnetic field recordings, over minutes, superimposed on the MRI of the individual. Here, a high resolution Fourier Transform is obtained over the entire recording period, leading to a detailed multi-frequency spectrum. Further analysis implements a total decomposition of the frequency components into functionally invariant entities, each having an invariant field pattern localizable in recording space. The method, addressed as functional tomography, makes it possible to find the distribution of magnetic field sources in space. Here, the method is applied to the analysis of simulated data, to oscillating signals activating a physical current dipoles phantom, and to recordings of spontaneous brain activity in 10 healthy adults. In the analysis of simulated data, 61 dipoles are localized with 0.7 mm precision. Concerning the physical phantom the method is able to localize three simultaneously activated current dipoles with 1 mm precision. Spatial resolution 3 mm was attained when localizing spontaneous alpha rhythm activity in 10 healthy adults, where the alpha peak was specified for each subject individually. Co-registration of the functional tomograms with each subject's head MRI localized alpha range activity to the occipital and/or posterior parietal brain region. This is the first application of this new functional tomography to human brain activity. The method successfully provides an overall view of brain electrical activity, a detailed spectral description and, combined with MRI, the localization of sources in anatomical brain space. PMID:26528119

How fire history, fire suppression practices and climate change affect wildfire regimes in Mediterranean landscapes.

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Lluís Brotons

Full Text Available Available data show that future changes in global change drivers may lead to an increasing impact of fires on terrestrial ecosystems worldwide. Yet, fire regime changes in highly humanised fire-prone regions are difficult to predict because fire effects may be heavily mediated by human activities We investigated the role of fire suppression strategies in synergy with climate change on the resulting fire regimes in Catalonia (north-eastern Spain. We used a spatially-explicit fire-succession model at the landscape level to test whether the use of different firefighting opportunities related to observed reductions in fire spread rates and effective fire sizes, and hence changes in the fire regime. We calibrated this model with data from a period with weak firefighting and later assess the potential for suppression strategies to modify fire regimes expected under different levels of climate change. When comparing simulations with observed fire statistics from an eleven-year period with firefighting strategies in place, our results showed that, at least in two of the three sub-regions analysed, the observed fire regime could not be reproduced unless taking into account the effects of fire suppression. Fire regime descriptors were highly dependent on climate change scenarios, with a general trend, under baseline scenarios without fire suppression, to large-scale increases in area burnt. Fire suppression strategies had a strong capacity to compensate for climate change effects. However, strong active fire suppression was necessary to accomplish such compensation, while more opportunistic fire suppression strategies derived from recent fire history only had a variable, but generally weak, potential for compensation of enhanced fire impacts under climate change. The concept of fire regime in the Mediterranean is probably better interpreted as a highly dynamic process in which the main determinants of fire are rapidly modified by changes in landscape

How fire history, fire suppression practices and climate change affect wildfire regimes in Mediterranean landscapes.

Science.gov (United States)

Brotons, Lluís; Aquilué, Núria; de Cáceres, Miquel; Fortin, Marie-Josée; Fall, Andrew

2013-01-01

Available data show that future changes in global change drivers may lead to an increasing impact of fires on terrestrial ecosystems worldwide. Yet, fire regime changes in highly humanised fire-prone regions are difficult to predict because fire effects may be heavily mediated by human activities We investigated the role of fire suppression strategies in synergy with climate change on the resulting fire regimes in Catalonia (north-eastern Spain). We used a spatially-explicit fire-succession model at the landscape level to test whether the use of different firefighting opportunities related to observed reductions in fire spread rates and effective fire sizes, and hence changes in the fire regime. We calibrated this model with data from a period with weak firefighting and later assess the potential for suppression strategies to modify fire regimes expected under different levels of climate change. When comparing simulations with observed fire statistics from an eleven-year period with firefighting strategies in place, our results showed that, at least in two of the three sub-regions analysed, the observed fire regime could not be reproduced unless taking into account the effects of fire suppression. Fire regime descriptors were highly dependent on climate change scenarios, with a general trend, under baseline scenarios without fire suppression, to large-scale increases in area burnt. Fire suppression strategies had a strong capacity to compensate for climate change effects. However, strong active fire suppression was necessary to accomplish such compensation, while more opportunistic fire suppression strategies derived from recent fire history only had a variable, but generally weak, potential for compensation of enhanced fire impacts under climate change. The concept of fire regime in the Mediterranean is probably better interpreted as a highly dynamic process in which the main determinants of fire are rapidly modified by changes in landscape, climate and

How Fire History, Fire Suppression Practices and Climate Change Affect Wildfire Regimes in Mediterranean Landscapes

Science.gov (United States)

Brotons, Lluís; Aquilué, Núria; de Cáceres, Miquel; Fortin, Marie-Josée; Fall, Andrew

2013-01-01

Available data show that future changes in global change drivers may lead to an increasing impact of fires on terrestrial ecosystems worldwide. Yet, fire regime changes in highly humanised fire-prone regions are difficult to predict because fire effects may be heavily mediated by human activities We investigated the role of fire suppression strategies in synergy with climate change on the resulting fire regimes in Catalonia (north-eastern Spain). We used a spatially-explicit fire-succession model at the landscape level to test whether the use of different firefighting opportunities related to observed reductions in fire spread rates and effective fire sizes, and hence changes in the fire regime. We calibrated this model with data from a period with weak firefighting and later assess the potential for suppression strategies to modify fire regimes expected under different levels of climate change. When comparing simulations with observed fire statistics from an eleven-year period with firefighting strategies in place, our results showed that, at least in two of the three sub-regions analysed, the observed fire regime could not be reproduced unless taking into account the effects of fire suppression. Fire regime descriptors were highly dependent on climate change scenarios, with a general trend, under baseline scenarios without fire suppression, to large-scale increases in area burnt. Fire suppression strategies had a strong capacity to compensate for climate change effects. However, strong active fire suppression was necessary to accomplish such compensation, while more opportunistic fire suppression strategies derived from recent fire history only had a variable, but generally weak, potential for compensation of enhanced fire impacts under climate change. The concept of fire regime in the Mediterranean is probably better interpreted as a highly dynamic process in which the main determinants of fire are rapidly modified by changes in landscape, climate and

Assessing fire impacts on the carbon stability of fire-tolerant forests.

Science.gov (United States)

Bennett, Lauren T; Bruce, Matthew J; Machunter, Josephine; Kohout, Michele; Krishnaraj, Saravanan Jangammanaidu; Aponte, Cristina

2017-12-01

The carbon stability of fire-tolerant forests is often assumed but less frequently assessed, limiting the potential to anticipate threats to forest carbon posed by predicted increases in forest fire activity. Assessing the carbon stability of fire-tolerant forests requires multi-indicator approaches that recognize the myriad ways that fires influence the carbon balance, including combustion, deposition of pyrogenic material, and tree death, post-fire decomposition, recruitment, and growth. Five years after a large-scale wildfire in southeastern Australia, we assessed the impacts of low- and high-severity wildfire, with and without prescribed fire (≤10 yr before), on carbon stocks in multiple pools, and on carbon stability indicators (carbon stock percentages in live trees and in small trees, and carbon stocks in char and fuels) in fire-tolerant eucalypt forests. Relative to unburned forest, high-severity wildfire decreased short-term (five-year) carbon stability by significantly decreasing live tree carbon stocks and percentage stocks in live standing trees (reflecting elevated tree mortality), by increasing the percentage of live tree carbon in small trees (those vulnerable to the next fire), and by potentially increasing the probability of another fire through increased elevated fine fuel loads. In contrast, low-severity wildfire enhanced carbon stability by having negligible effects on aboveground stocks and indicators, and by significantly increasing carbon stocks in char and, in particular, soils, indicating pyrogenic carbon accumulation. Overall, recent preceding prescribed fire did not markedly influence wildfire effects on short-term carbon stability at stand scales. Despite wide confidence intervals around mean stock differences, indicating uncertainty about the magnitude of fire effects in these natural forests, our assessment highlights the need for active management of carbon assets in fire-tolerant eucalypt forests under contemporary fire regimes

Contrasting spatial patterns in active-fire and fire-suppressed Mediterranean climate old-growth mixed conifer forests

Science.gov (United States)

Danny L. Fry; Scott L. Stephens; Brandon M. Collins; Malcolm North; Ernesto Franco-Vizcaino; Samantha J. Gill

2014-01-01

In Mediterranean environments in western North America, historic fire regimes in frequent-fire conifer forests are highly variable both temporally and spatially. This complexity influenced forest structure and spatial patterns, but some of this diversity has been lost due to anthropogenic disruption of ecosystem processes, including fire. Information from reference...

FIRE PERMIT NOW ON EDH!

CERN Multimedia

TIS General Safety Group or

2001-01-01

The electronic version of the Fire Permit form is now active. The aim of the Fire Permit procedure is to reduce the risk of fire or explosion. It is mandatory when performing 'hot work' (mainly activities which involve the use of naked flames or other heat sources - e.g. welding, brazing, cutting, grinding, etc.). Its use is explained in the CERN Fire Protection Code E. (Fire Protection) The new electronic form, which is substantially unchanged from the previous authorizing procedure, will be available on the Electronic Document Handling system (https://edh.cern.ch/) as of 1st September 2001. From this date use of the paper version should be discontinued.

MOTOR UNIT FIRING RATES DURING SPASMS IN THENAR MUSCLES OF SPINAL CORD INJURED SUBJECTS

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Inge eZijdewind

2014-11-01

Full Text Available Abstract Involuntary contractions of paralyzed muscles (spasms commonly disrupt daily activities and rehabilitation after human spinal cord injury. Our aim was to examine the recruitment, firing rate modulation, and derecruitment of motor units that underlie spasms of thenar muscles after cervical spinal cord injury. Intramuscular electromyographic activity (EMG, surface EMG, and force were recorded during thenar muscle spasms that occurred spontaneously or that were triggered by movement of a shoulder or leg. Most spasms were submaximal (mean: 39%, SD: 33 of the force evoked by median nerve stimulation at 50 Hz with strong relationships between EMG and force (R2>0.69. Unit recruitment occurred over a wide force range (0.2-103% of 50 Hz force. Significant unit rate modulation occurred during spasms (frequency at 25% maximal force: 8.8 Hz, 3.3 SD; at maximal force: 16.1 Hz, 4.1 SD. Mean recruitment frequency (7.1 Hz, 3.2 SD was significantly higher than derecruitment frequency (5.4 Hz, 2.4 SD. Coactive unit pairs that fired for more than 4 s showed high (R2>0.7, n=4 or low (R2:0.3-0.7, n=12 rate-rate correlations, and derecruitment reversals (21 pairs, 29%. Later recruited units had higher or lower maximal firing rates than lower threshold units. These discrepant data show that coactive motoneurons are driven by both common inputs and by synaptic inputs from different sources during muscle spasms. Further, thenar motoneurons can still fire at high rates in response to various peripheral inputs after spinal cord injury, supporting the idea that low maximal voluntary firing rates and forces in thenar muscles result from reduced descending drive.

Urokinase vs Tissue-Type Plasminogen Activator for Thrombolytic Evacuation of Spontaneous Intracerebral Hemorrhage in Basal Ganglia

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Yuqian Li

2017-08-01

Full Text Available Spontaneous intracerebral hemorrhage (ICH is a devastating form of stroke, which leads to a high rate of mortality and poor neurological outcomes worldwide. Thrombolytic evacuation with urokinase-type plasminogen activator (uPA or tissue-type plasminogen activator (tPA has been showed to be a hopeful treatment for ICH. However, to the best of our knowledge, no clinical trials were reported to compare the efficacy and safety of these two fibrinolytics administrated following minimally invasive stereotactic puncture (MISP in patients with spontaneous basal ganglia ICH. Therefore, the authors intended here to evaluate the differential impact of uPA and tPA in a retrospective study. In the present study, a total of 86 patients with spontaneous ICH in basal ganglia using MISP received either uPA (uPA group, n = 45 or tPA (tPA group, n = 41, respectively. The clinical baseline characteristics prior to the operation were collected. In addition, therapeutic responses were assessed by the short-term outcomes within 30 days postoperation, as well as long-term outcomes at 1 year postoperation. Our findings showed that, in comparison with tPA, uPA was able to better promote hematoma evacuation and ameliorate perihematomal edema, but the differences were not statistically significant. Moreover, the long-term functional outcomes of both groups were similar, with no statistical difference. In conclusion, these results provide evidence supporting that uPA and tPA are similar in the efficacy and safety for thrombolytic evacuation in combination with MISP in patients with spontaneous basal ganglia ICH.

Integrated Active Fire Retrievals and Biomass Burning Emissions Using Complementary Near-Coincident Ground, Airborne and Spaceborne Sensor Data

Science.gov (United States)

Schroeder, Wilfrid; Ellicott, Evan; Ichoku, Charles; Ellison, Luke; Dickinson, Matthew B.; Ottmar, Roger D.; Clements, Craig; Hall, Dianne; Ambrosia, Vincent; Kremens, Robert

2013-01-01

Ground, airborne and spaceborne data were collected for a 450 ha prescribed fire implemented on 18 October 2011 at the Henry W. Coe State Park in California. The integration of various data elements allowed near coincident active fire retrievals to be estimated. The Autonomous Modular Sensor-Wildfire (AMS) airborne multispectral imaging system was used as a bridge between ground and spaceborne data sets providing high quality reference information to support satellite fire retrieval error analyses and fire emissions estimates. We found excellent agreement between peak fire radiant heat flux data (less than 1% error) derived from near-coincident ground radiometers and AMS. Both MODIS and GOES imager active fire products were negatively influenced by the presence of thick smoke, which was misclassified as cloud by their algorithms, leading to the omission of fire pixels beneath the smoke, and resulting in the underestimation of their retrieved fire radiative power (FRP) values for the burn plot, compared to the reference airborne data. Agreement between airborne and spaceborne FRP data improved significantly after correction for omission errors and atmospheric attenuation, resulting in as low as 5 difference between AquaMODIS and AMS. Use of in situ fuel and fire energy estimates in combination with a collection of AMS, MODIS, and GOES FRP retrievals provided a fuel consumption factor of 0.261 kg per MJ, total energy release of 14.5 x 10(exp 6) MJ, and total fuel consumption of 3.8 x 10(exp 6) kg. Fire emissions were calculated using two separate techniques, resulting in as low as 15 difference for various species

Circadian and individual variations in duration of spontaneous activity among ankle muscles of the cat

NARCIS (Netherlands)

Hensbergen, E; Kernell, D

This article concerns the spontaneous motor behavior of cat hindlimb muscles and muscle regions using 24-h electromyographic (EMG) recordings. Previously, we found marked differences in average daily "duty time" (i.e., the percentage of total sampling time filled with EMG activity) between different

Alpha-Band Activity Reveals Spontaneous Representations of Spatial Position in Visual Working Memory.

Science.gov (United States)

Foster, Joshua J; Bsales, Emma M; Jaffe, Russell J; Awh, Edward

2017-10-23

An emerging view suggests that spatial position is an integral component of working memory (WM), such that non-spatial features are bound to locations regardless of whether space is relevant [1, 2]. For instance, past work has shown that stimulus position is spontaneously remembered when non-spatial features are stored. Item recognition is enhanced when memoranda appear at the same location where they were encoded [3-5], and accessing non-spatial information elicits shifts of spatial attention to the original position of the stimulus [6, 7]. However, these findings do not establish that a persistent, active representation of stimulus position is maintained in WM because similar effects have also been documented following storage in long-term memory [8, 9]. Here we show that the spatial position of the memorandum is actively coded by persistent neural activity during a non-spatial WM task. We used a spatial encoding model in conjunction with electroencephalogram (EEG) measurements of oscillatory alpha-band (8-12 Hz) activity to track active representations of spatial position. The position of the stimulus varied trial to trial but was wholly irrelevant to the tasks. We nevertheless observed active neural representations of the original stimulus position that persisted throughout the retention interval. Further experiments established that these spatial representations are dependent on the volitional storage of non-spatial features rather than being a lingering effect of sensory energy or initial encoding demands. These findings provide strong evidence that online spatial representations are spontaneously maintained in WM-regardless of task relevance-during the storage of non-spatial features. Copyright © 2017 Elsevier Ltd. All rights reserved.

The use of ATSR active fire counts for estimating relative patterns of biomass burning - A study from the boreal forest region

NARCIS (Netherlands)

Kasischke, Eric S.; Hewson, Jennifer H.; Stocks, Brian; van der Werf, Guido; Randerson, James T.

2003-01-01

Satellite fire products have the potential to construct inter-annual time series of fire activity, but estimating area burned requires considering biases introduced by orbiting geometry, fire behavior, and the presence of clouds and smoke. Here we evaluated the performance of fire counts from the

Enhancing fire science exchange: The Northern Rockies Fire Science Network [poster

Science.gov (United States)

Vita Wright

2011-01-01

The Joint Fire Science Program is developing a national network of knowledge exchange consortia comprised of interested management and science stakeholders working together to tailor and actively demonstrate existing fire science information to benefit management.

Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells.

Science.gov (United States)

Rudolph, Stephanie; Hull, Court; Regehr, Wade G

2015-11-25

Interneurons are essential to controlling excitability, timing, and synaptic integration in neuronal networks. Golgi cells (GoCs) serve these roles at the input layer of the cerebellar cortex by releasing GABA to inhibit granule cells (grcs). GoCs are excited by mossy fibers (MFs) and grcs and provide feedforward and feedback inhibition to grcs. Here we investigate two important aspects of GoC physiology: the properties of GoC dendrites and the role of calcium signaling in regulating GoC spontaneous activity. Although GoC dendrites are extensive, previous studies concluded they are devoid of voltage-gated ion channels. Hence, the current view holds that somatic voltage signals decay passively within GoC dendrites, and grc synapses onto distal dendrites are not amplified and are therefore ineffective at firing GoCs because of strong passive attenuation. Using whole-cell recording and calcium imaging in rat slices, we find that dendritic voltage-gated sodium channels allow somatic action potentials to activate voltage-gated calcium channels (VGCCs) along the entire dendritic length, with R-type and T-type VGCCs preferentially located distally. We show that R- and T-type VGCCs located in the dendrites can boost distal synaptic inputs and promote burst firing. Active dendrites are thus critical to the regulation of GoC activity, and consequently, to the processing of input to the cerebellar cortex. In contrast, we find that N-type channels are preferentially located near the soma, and control the frequency and pattern of spontaneous firing through their close association with calcium-activated potassium (KCa) channels. Thus, VGCC types are differentially distributed and serve specialized functions within GoCs. Interneurons are essential to neural processing because they modulate excitability, timing, and synaptic integration within circuits. At the input layer of the cerebellar cortex, a single type of interneuron, the Golgi cell (GoC), carries these functions. The

Supporting FIRE-suppression strategies combining fire spread MODelling and SATellite data in an operational context in Portugal: the FIRE-MODSAT project

Science.gov (United States)

Sá, Ana C. L.; Benali, Akli; Pinto, Renata M. S.; Pereira, José M. C.; Trigo, Ricardo M.; DaCamara, Carlos C.

2014-05-01

Large wildfires are infrequent but account for the most severe environmental, ecological and socio-economic impacts. In recent years Portugal has suffered the impact of major heat waves that fuelled records of burnt area exceeding 400.000ha and 300.000ha in 2003 and 2005, respectively. According to the latest IPCC reports, the frequency and amplitude of summer heat waves over Iberia will very likely increase in the future. Therefore, most climate change studies point to an increase in the number and extent of wildfires. Thus, an increase in both wildfire impacts and fire suppression difficulties is expected. The spread of large wildfires results from a complex interaction between topography, meteorology and fuel properties. Wildfire spread models (e.g. FARSITE) are commonly used to simulate fire growth and behaviour and are an essential tool to understand their main drivers. Additionally, satellite active-fire data have been used to monitor the occurrence, extent, and spread of wildfires. Both satellite data and fire spread models provide different types of information about the spatial and temporal distribution of large wildfires and can potentially be used to support strategic decisions regarding fire suppression resource allocation. However, they have not been combined in a manner that fully exploits their potential and minimizes their limitations. A knowledge gap still exists in understanding how to minimize the impacts of large wildfires, leading to the following research question: What can we learn from past large wildfires in order to mitigate future fire impacts? FIRE-MODSAT is a one-year funded project by the Portuguese Foundation for the Science and Technology (FCT) that is founded on this research question, with the main goal of improving our understanding on the interactions between fire spread and its environmental drivers, to support fire management decisions in an operational context and generate valuable information to improve the efficiency of the

A spiking network model of cerebellar Purkinje cells and molecular layer interneurons exhibiting irregular firing

Directory of Open Access Journals (Sweden)

William eLennon

2014-12-01

Full Text Available While the anatomy of the cerebellar microcircuit is well studied, how it implements cerebellar function is not understood. A number of models have been proposed to describe this mechanism but few emphasize the role of the vast network Purkinje cells (PKJs form with the molecular layer interneurons (MLIs – the stellate and basket cells. We propose a model of the MLI-PKJ network composed of simple spiking neurons incorporating the major anatomical and physiological features. In computer simulations, the model reproduces the irregular firing patterns observed in PKJs and MLIs in vitro and a shift toward faster, more regular firing patterns when inhibitory synaptic currents are blocked. In the model, the time between PKJ spikes is shown to be proportional to the amount of feedforward inhibition from an MLI on average. The two key elements of the model are: (1 spontaneously active PKJs and MLIs due to an endogenous depolarizing current, and (2 adherence to known anatomical connectivity along a parasagittal strip of cerebellar cortex. We propose this model to extend previous spiking network models of the cerebellum and for further computational investigation into the role of irregular firing and MLIs in cerebellar learning and function.

Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients

DEFF Research Database (Denmark)

Ge, Hong-You; Wang, Ying; Fernández-de-las-Peñas, César

2011-01-01

It has previously been reported that local and referred pain from active myofascial trigger points (MTPs) in the neck and shoulder region contribute to fibromyalgia (FM) pain and that the pain pattern induced from active MTPs can reproduce parts of the spontaneous clinical FM pain pattern. The cu...

46 CFR 28.820 - Fire pumps, fire mains, fire hydrants, and fire hoses.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Fire pumps, fire mains, fire hydrants, and fire hoses... REQUIREMENTS FOR COMMERCIAL FISHING INDUSTRY VESSELS Aleutian Trade Act Vessels § 28.820 Fire pumps, fire mains, fire hydrants, and fire hoses. (a) Each vessel must be equipped with a self-priming, power driven fire...

Change in activity of catalysts for the oxidation of tritium during a fire event

International Nuclear Information System (INIS)

Iwai, Yasunori; Sato, Katsumi; Yamanishi, Toshihiko

2012-01-01

Highlights: ► We experimentally demonstrated the influence of produced gases from burned low-halogen cable on the activity of catalysts for tritium oxidation. ► At 423 K, no considerable decrease in catalytic activity was observed. ► At 293 K, considerable increase in catalytic activity was initially observed due to the effect of produced hydrogen. Then the temporary decrease was observed due mainly to the effect of produced moisture, however the activity was gradually recovered. - Abstract: The catalytic performance should be maintained in any off normal events. Fire accident is the typical off normal event. In the fusion plant, typical combustibles are evaluated to be polymeric low-halogen cables. Produced gases from burned low-halogen cable may affect the activity of catalysts for the oxidation of tritium. We experimentally demonstrated the influence of produced gases from burned low-halogen cable on the activity of catalyst using tritium gas. Our evaluation showed that ethylene, methane and benzene were major produced gases. The activity of catalysts for the oxidation of tritium during a fire event was evaluated using a commercial hydrophilic Pt/Al 2 O 3 catalyst and a commercial hydrophobic Pt-catalyst. The temperature of catalytic reactor was selected to be 423 and 293 K. At 423 K, no considerable decrease in catalytic activity was observed for both catalysts even in the presence of produced gases from burned low-halogen cable. At 293 K, considerable increase in catalytic activity was initially observed for both catalysts due to the effect of produced hydrogen. Then the temporary decrease was observed, however the catalytic activity was gradually recovered to be the original activity. Consequently, the irreversible decrease in activity of the catalysts during a fire event was not observed.

Increased dopaminergic activity in socially isolated rats: an electrophysiological study

DEFF Research Database (Denmark)

Fabricius, Katrine; Helboe, Lone; Fink-Jensen, Anders

2010-01-01

The development of animal models mimicking symptoms associated with schizophrenia has been a critical step in understanding the neurobiological mechanisms underlying the disease. Long-term social isolation from weaning in rodents, a model based on the neurodevelopmental hypothesis of schizophrenia......, has been suggested to mimic some of the deficits seen in schizophrenic patients. We confirm in the present study that socially isolated rats display an increase in both spontaneous and d-amphetamine-induced locomotor activity, as well as deficits in sensorimotor gating as assessed in a pre......, and a change of firing activity towards a more irregular and bursting firing pattern. Taken together, our findings suggest that the behavioral phenotype induced by social isolation may be driven by an overactive dopamine system....

Bilateral Changes of Spontaneous Activity Within the Central Auditory Pathway Upon Chronic Unilateral Intracochlear Electrical Stimulation.

Science.gov (United States)

Basta, Dietmar; Götze, Romy; Gröschel, Moritz; Jansen, Sebastian; Janke, Oliver; Tzschentke, Barbara; Boyle, Patrick; Ernst, Arne

2015-12-01

In recent years, cochlear implants have been applied successfully for the treatment of unilateral hearing loss with quite surprising benefit. One reason for this successful treatment, including the relief from tinnitus, could be the normalization of spontaneous activity in the central auditory pathway because of the electrical stimulation. The present study, therefore, investigated at a cellular level, the effect of a unilateral chronic intracochlear stimulation on key structures of the central auditory pathway. Normal-hearing guinea pigs were mechanically single-sided deafened through a standard HiFocus1j electrode array (on a HiRes 90k cochlear implant) being inserted into the first turn of the cochlea. Four to five electrode contacts could be used for the stimulation. Six weeks after surgery, the speech processor (Auria) was fitted, based on tNRI values and mounted on the animal's back. The two experimental groups were stimulated 16 hours per day for 90 days, using a HiRes strategy based on different stimulation rates (low rate (275 pps/ch), high rate (5000 pps/ch)). The results were compared with those of unilateral deafened controls (implanted but not stimulated), as well as between the treatment groups. All animals experienced a standardized free field auditory environment. The low-rate group showed a significantly lower average spontaneous activity bilaterally in the dorsal cochlear nucleus and the medial geniculate body than the controls. However, there was no difference in the inferior colliculus and the primary auditory cortex. Spontaneous activity of the high-rate group was also reduced bilaterally in the dorsal cochlear nucleus and in the primary auditory cortex. No differences could be observed between the high-rate group and the controls in the contra-lateral inferior colliculus and medial geniculate body. The high-rate group showed bilaterally a higher activity in the CN and the MGB compared with the low-rate group, whereas in the IC and in the

acme: The Amendable Coal-Fire Modeling Exercise. A C++ Class Library for the Numerical Simulation of Coal-Fires

Science.gov (United States)

Wuttke, Manfred W.

2017-04-01

At LIAG, we use numerical models to develop and enhance understanding of coupled transport processes and to predict the dynamics of the system under consideration. Topics include geothermal heat utilization, subrosion processes, and spontaneous underground coal fires. Although the details make it inconvenient if not impossible to apply a single code implementation to all systems, their investigations go along similar paths: They all depend on the solution of coupled transport equations. We thus saw a need for a modular code system with open access for the various communities to maximize the shared synergistic effects. To this purpose we develop the oops! ( open object-oriented parallel solutions) - toolkit, a C++ class library for the numerical solution of mathematical models of coupled thermal, hydraulic and chemical processes. This is used to develop problem-specific libraries like acme( amendable coal-fire modeling exercise), a class library for the numerical simulation of coal-fires and applications like kobra (Kohlebrand, german for coal-fire), a numerical simulation code for standard coal-fire models. Basic principle of the oops!-code system is the provision of data types for the description of space and time dependent data fields, description of terms of partial differential equations (pde), their discretisation and solving methods. Coupling of different processes, described by their particular pde is modeled by an automatic timescale-ordered operator-splitting technique. acme is a derived coal-fire specific application library, depending on oops!. If specific functionalities of general interest are implemented and have been tested they will be assimilated into the main oops!-library. Interfaces to external pre- and post-processing tools are easily implemented. Thus a construction kit which can be arbitrarily amended is formed. With the kobra-application constructed with acme we study the processes and propagation of shallow coal seam fires in particular in

Abnormal regional spontaneous neuronal activity associated with symptom severity in treatment-naive patients with obsessive-compulsive disorder revealed by resting-state functional MRI.

Science.gov (United States)

Qiu, Linlin; Fu, Xiangshuai; Wang, Shuai; Tang, Qunfeng; Chen, Xingui; Cheng, Lin; Zhang, Fuquan; Zhou, Zhenhe; Tian, Lin

2017-02-15

A large number of neuroimaging studies have revealed the dysfunction of brain activities in obsessive-compulsive disorder (OCD) during various tasks. However, regional spontaneous activity abnormalities in OCD are gradually being revealed. In this current study, we aimed to investigate cerebral regions with abnormal spontaneous activity using resting-state functional magnetic resonance imaging (fMRI) and further explored the relationship between the spontaneous neuronal activity and symptom severity of patients with OCD. Thirty-one patients with OCD and 32 age-and sex-matched normal controls received the fMRI scans and fractional amplitude of low-frequency fluctuation (fALFF) approach was applied to identify the abnormal brain activity. We found that patients with OCD showed decreased fALFF not only in the cortical-striato-thalamo-cortical (CSTC) circuits like the thalamus, but also in other cerebral systems like the cerebellum, the parietal cortex and the temporal cortex. Additionally, OCD patients demonstrated significant associations between decreased fALFF and obsessive-compulsive symptom severity in the thalamus, the paracentral lobule and the cerebellum. Our results provide evidence for abnormal spontaneous neuronal activity in distributed cerebral areas and support the notion that brain areas outside the CSTC circuits may also play an important role in the pathophysiology of OCD. Copyright © 2017 Elsevier B.V. All rights reserved.

Biologically active polymers from spontaneous carotenoid oxidation: a new frontier in carotenoid activity.

Directory of Open Access Journals (Sweden)

James B Johnston

Full Text Available In animals carotenoids show biological activity unrelated to vitamin A that has been considered to arise directly from the behavior of the parent compound, particularly as an antioxidant. However, the very property that confers antioxidant activity on some carotenoids in plants also confers susceptibility to oxidative transformation. As an alternative, it has been suggested that carotenoid oxidative breakdown or metabolic products could be the actual agents of activity in animals. However, an important and neglected aspect of the behavior of the highly unsaturated carotenoids is their potential to undergo addition of oxygen to form copolymers. Recently we reported that spontaneous oxidation of ß-carotene transforms it into a product dominated by ß-carotene-oxygen copolymers. We now report that the polymeric product is biologically active. Results suggest an overall ability to prime innate immune function to more rapidly respond to subsequent microbial challenges. An underlying structural resemblance to sporopollenin, found in the outer shell of spores and pollen, may allow the polymer to modulate innate immune responses through interactions with the pattern recognition receptor system. Oxygen copolymer formation appears common to all carotenoids, is anticipated to be widespread, and the products may contribute to the health benefits of carotenoid-rich fruits and vegetables.

Post-fire vegetation and fuel development influences fire severity patterns in reburns.

Science.gov (United States)

Coppoletta, Michelle; Merriam, Kyle E; Collins, Brandon M

2016-04-01

In areas where fire regimes and forest structure have been dramatically altered, there is increasing concern that contemporary fires have the potential to set forests on a positive feedback trajectory with successive reburns, one in which extensive stand-replacing fire could promote more stand-replacing fire. Our study utilized an extensive set of field plots established following four fires that occurred between 2000 and 2010 in the northern Sierra Nevada, California, USA that were subsequently reburned in 2012. The information obtained from these field plots allowed for a unique set of analyses investigating the effect of vegetation, fuels, topography, fire weather, and forest management on reburn severity. We also examined the influence of initial fire severity and time since initial fire on influential predictors of reburn severity. Our results suggest that high- to moderate-severity fire in the initial fires led to an increase in standing snags and shrub vegetation, which in combination with severe fire weather promoted high-severity fire effects in the subsequent reburn. Although fire behavior is largely driven by weather, our study demonstrates that post-fire vegetation composition and structure are also important drivers of reburn severity. In the face of changing climatic regimes and increases in extreme fire weather, these results may provide managers with options to create more fire-resilient ecosystems. In areas where frequent high-severity fire is undesirable, management activities such as thinning, prescribed fire, or managed wildland fire can be used to moderate fire behavior not only prior to initial fires, but also before subsequent reburns.

Multiplatform inversion of the 2013 Rim Fire smoke emissions using regional-scale modeling: important nocturnal fire activity, air quality, and climate impacts

Science.gov (United States)

Saide, P. E.; Peterson, D. A.; da Silva, A. M., Jr.; Ziemba, L. D.; Anderson, B.; Diskin, G. S.; Sachse, G. W.; Hair, J. W.; Butler, C. F.; Fenn, M. A.; Jimenez, J. L.; Campuzano Jost, P.; Dibb, J. E.; Yokelson, R. J.; Toon, B.; Carmichael, G. R.

2014-12-01

Large wildfire events are increasingly recognized for their adverse effects on air quality and visibility, thus providing motivation for improving smoke emission estimates. The Rim Fire, one of the largest events in California's history, produced a large smoke plume that was sampled by the Studies of Emissions and Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys (SEAC4RS) DC-8 aircraft with a full suite of in-situ and remote sensing measurements on 26-27 August 2013. We developed an inversion methodology which uses the WRF-Chem modeling system to constrain hourly fire emissions, using as initial estimates the NASA Quick Fire Emissions Dataset (QFED). This method differs from the commonly performed top-down estimates that constrain daily (or longer time scale) emissions. The inversion method is able to simultaneously improve the model fit to various SEAC4RS airborne measurements (e.g., organic aerosol, carbon monoxide (CO), aerosol extinction), ground based measurements (e.g., AERONET aerosol optical depth (AOD), CO), and satellite data (MODIS AOD) by modifying fire emissions and utilizing the information content of all these measurements. Preliminary results show that constrained emissions for a 6 day period following the largest fire growth are a factor 2-4 higher than the initial top-down estimates. Moreover, there is a tendency to increase nocturnal emissions by factors sometimes larger than 20, indicating that vigorous fire activity continued during the night. This deviation from a typical diurnal cycle is confirmed using geostationary satellite data. The constrained emissions also have a larger day-to-day variability than the initial emissions and correlate better to daily area burned estimates as observed by airborne infrared measurements (NIROPS). Experiments with the assimilation system show that performing the inversion using only satellite AOD data produces much smaller correction factors than when using all available data

Vegetation fires and air pollution in Vietnam.

Science.gov (United States)

Le, Thanh Ha; Thanh Nguyen, Thi Nhat; Lasko, Kristofer; Ilavajhala, Shriram; Vadrevu, Krishna Prasad; Justice, Chris

2014-12-01

Forest fires are a significant source of air pollution in Asia. In this study, we integrate satellite remote sensing data and ground-based measurements to infer fire-air pollution relationships in selected regions of Vietnam. We first characterized the active fires and burnt areas at a regional scale from MODIS satellite data. We then used satellite-derived active fire data to correlate the resulting atmospheric pollution. Further, we analyzed the relationship between satellite atmospheric variables and ground-based air pollutant parameters. Our results show peak fire activity during March in Vietnam, with hotspots in the Northwest and Central Highlands. Active fires were significantly correlated with UV Aerosol Index (UVAI), aerosol extinction absorption optical depth (AAOD), and Carbon Monoxide. The use of satellite aerosol optical thickness improved the prediction of Particulate Matter (PM) concentration significantly. Copyright © 2014 Elsevier Ltd. All rights reserved.

46 CFR 28.315 - Fire pumps, fire mains, fire hydrants, and fire hoses.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Fire pumps, fire mains, fire hydrants, and fire hoses... After September 15, 1991, and That Operate With More Than 16 Individuals on Board § 28.315 Fire pumps, fire mains, fire hydrants, and fire hoses. (a) Each vessel 36 feet (11.8 meters) or more in length must...

Acute ethanol exposure inhibits silencing of cerebellar Golgi cell firing induced by granule cell axon input

Directory of Open Access Journals (Sweden)

Paolo eBotta

2014-02-01

Full Text Available Golgi cells (GoCs are specialized interneurons that provide inhibitory input to granule cells in the cerebellar cortex. GoCs are pacemaker neurons that spontaneously fire action potentials, triggering spontaneous inhibitory postsynaptic currents in granule cells and also contributing to the generation tonic GABAA receptor-mediated currents in granule cells. In turn, granule cell axons provide feedback glutamatergic input to GoCs. It has been shown that high frequency stimulation of granule cell axons induces a transient pause in GoC firing in a type 2-metabotropic glutamate receptor (mGluR2-dependent manner. Here, we investigated the effect ethanol on the pause of GoC firing induced by high frequency stimulation of granule cell axons. GoC electrophysiological recordings were performed in parasagittal cerebellar vermis slices from postnatal day 23 to 26 rats. Loose-patch cell-attached recordings revealed that ethanol (40 mM reversibly decreases the pause duration. An antagonist of mGluR2 reduced the pause duration but did not affect the effect of ethanol. Whole-cell voltage-clamp recordings showed that currents evoked by an mGluR2 agonist were not significantly affected by ethanol. Perforated-patch experiments in which hyperpolarizing and depolarizing currents were injected into GoCs demonstrated that there is an inverse relationship between spontaneous firing and pause duration. Slight inhibition of the Na+/K+ pump mimicked the effect of ethanol on pause duration. In conclusion, ethanol reduces the granule cell axon-mediated feedback mechanism by reducing the input responsiveness of GoCs. This would result in a transient increase of GABAA receptor-mediated inhibition of granule cells, limiting information flow at the input stage of the cerebellar cortex.

Contrasting Spatial Patterns in Active-Fire and Fire-Suppressed Mediterranean Climate Old-Growth Mixed Conifer Forests

OpenAIRE

Fry, Danny L.; Stephens, Scott L.; Collins, Brandon M.; North, Malcolm P.; Franco-Vizcaíno, Ernesto; Gill, Samantha J.

2014-01-01

In Mediterranean environments in western North America, historic fire regimes in frequent-fire conifer forests are highly variable both temporally and spatially. This complexity influenced forest structure and spatial patterns, but some of this diversity has been lost due to anthropogenic disruption of ecosystem processes, including fire. Information from reference forest sites can help management efforts to restore forests conditions that may be more resilient to future changes in disturbanc...

Fire and smoke retardants

Science.gov (United States)

Drews, M. J.

Despite a reduction in Federal regulatory activity, research concerned with flame retardancy and smoke suppression in the private sector appears to be increasing. This trend seem related to the increased utilization of plastics for end uses which traditionally have employed metal or wood products. As a result, new markets have appeared for thermally stable and fire resistance thermoplastic materials, and this in turn has spurred research and development activity. In addition, public awareness of the dangers associated with fire has increased as a result of several highly publicized hotel and restaurant fires within the past two years. The consumers recognition of flammability characteristics as important materials property considerations has increased. The current status of fire and smoke retardant chemistry and research are summarized.

Validation of MODIS and SEVIRI Active Fire Monitoring products over Western Romania. Case study: Arad County

Science.gov (United States)

Oanea, Lavinia; Alina Ristea, Mihaela

2014-05-01

At the national level, the issue of wildfire monitoring represents a long debated topic. However, in the present situation, fire management requires various improvements in terms of detection, monitoring and post-fire analysis. The objectives of this study are to validate the data provided by MODIS (Terra and Aqua) Active Fire Monitoring and SEVIRI (MSG) FIR (Active Fire Monitoring) satellite products, with wildfires field data from The Romanian General Inspectorate for Emergency Situations (IGSU) (1), to chart the efficiency of satellite products in locating fires and study their strengths and weaknesses using a SWOT analysis (2). This is the initial step of a larger project that aims to implement an online Geographic Information System for fire management that will ease wildfire data manipulation and facilitate the decision making process. In order to do so, the current study objectives must be achieved. Our general strategy is to determine the consistency of direct (field measurements) and indirect (satellite data) observations. Depending on the amount of field information, the fire characteristics (location, frequency, extension area, moment of occurrence, type of fire, and others) will be studied through a statistical analysis. The products show some peculiar restrictiveness like spatial and temporal resolution. Specifically, we will process and interpret satellite products to identify wildfires according to the data from IGSU using specialized software. The case study for the application of these procedures is a set of fire events from Arad county - Romania, that occurred between 2007 and 2013. In order to do so, it is important to compare results from different sensors with field information through various methods and to use only consistent results. The results will play an important role in achieving the above mentioned informational system, which will integrate field information, satellite data and values of parameters that influence the evolution of

Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI

Science.gov (United States)

Fox, Michael D.; Qian, Tianyi; Madsen, Joseph R.; Wang, Danhong; Li, Meiling; Ge, Manling; Zuo, Huan-cong; Groppe, David M.; Mehta, Ashesh D.; Hong, Bo; Liu, Hesheng

2016-01-01

Noninvasive localization of brain function is used to understand and treat neurological disease, exemplified by pre-operative fMRI mapping prior to neurosurgical intervention. The principal approach for generating these maps relies on brain responses evoked by a task and, despite known limitations, has dominated clinical practice for over 20 years. Recently, pre-operative fMRI mapping based on correlations in spontaneous brain activity has been demonstrated, however this approach has its own limitations and has not seen widespread clinical use. Here we show that spontaneous and task-based mapping can be performed together using the same pre-operative fMRI data, provide complimentary information relevant for functional localization, and can be combined to improve identification of eloquent motor cortex. Accuracy, sensitivity, and specificity of our approach are quantified through comparison with electrical cortical stimulation mapping in eight patients with intractable epilepsy. Broad applicability and reproducibility of our approach is demonstrated through prospective replication in an independent dataset of six patients from a different center. In both cohorts and every individual patient, we see a significant improvement in signal to noise and mapping accuracy independent of threshold, quantified using receiver operating characteristic curves. Collectively, our results suggest that modifying the processing of fMRI data to incorporate both task-based and spontaneous activity significantly improves functional localization in pre-operative patients. Because this method requires no additional scan time or modification to conventional pre-operative data acquisition protocols it could have widespread utility. PMID:26408860

On-off intermittency in time series of spontaneous paroxysmal activity in rats with genetic absence epilepsy

International Nuclear Information System (INIS)

Hramov, Alexander; Koronovskii, Alexey A.; Midzyanovskaya, I.S.; Sitnikova, E.; Rijn, C.M. van

2006-01-01

In the present paper we consider the on-off intermittency phenomena observed in time series of spontaneous paroxysmal activity in rats with genetic absence epilepsy. The method to register and analyze the electroencephalogram with the help of continuous wavelet transform is also suggested

Seasonal forecasting of fire over Kalimantan, Indonesia

Science.gov (United States)

Spessa, A. C.; Field, R. D.; Pappenberger, F.; Langner, A.; Englhart, S.; Weber, U.; Stockdale, T.; Siegert, F.; Kaiser, J. W.; Moore, J.

2015-03-01

Large-scale fires occur frequently across Indonesia, particularly in the southern region of Kalimantan and eastern Sumatra. They have considerable impacts on carbon emissions, haze production, biodiversity, health, and economic activities. In this study, we demonstrate that severe fire and haze events in Indonesia can generally be predicted months in advance using predictions of seasonal rainfall from the ECMWF System 4 coupled ocean-atmosphere model. Based on analyses of long, up-to-date series observations on burnt area, rainfall, and tree cover, we demonstrate that fire activity is negatively correlated with rainfall and is positively associated with deforestation in Indonesia. There is a contrast between the southern region of Kalimantan (high fire activity, high tree cover loss, and strong non-linear correlation between observed rainfall and fire) and the central region of Kalimantan (low fire activity, low tree cover loss, and weak, non-linear correlation between observed rainfall and fire). The ECMWF seasonal forecast provides skilled forecasts of burnt and fire-affected area with several months lead time explaining at least 70% of the variance between rainfall and burnt and fire-affected area. Results are strongly influenced by El Niño years which show a consistent positive bias. Overall, our findings point to a high potential for using a more physical-based method for predicting fires with several months lead time in the tropics rather than one based on indexes only. We argue that seasonal precipitation forecasts should be central to Indonesia's evolving fire management policy.

Sources of variation and genetic profile of spontaneous, out-of-season ovulatory activity in the Chios sheep

Directory of Open Access Journals (Sweden)

Kouttos Athanasios

2003-01-01

Full Text Available Abstract Organising the breeding plan of a seasonally breeding species, such as sheep, presents a challenge to farmers and the industry as a whole, since both economical and biological considerations need to be carefully balanced. Understanding the breeding activity of individual animals becomes a prerequisite for a successful breeding program. This study set out to investigate the sources of variation and the genetic profile of the spontaneous, out-of-season ovulatory activity of ewes of the Chios dairy sheep breed in Greece. The definition of the trait was based on blood progesterone levels, measured before exposing the ewes to rams, which marks the onset of the usual breeding season. Data were 707 records, taken over two consecutive years, of 435 ewes kept at the Agricultural Research Station of Chalkidiki in northern Greece. When all available pedigree was included, the total number of animals involved was 1068. On average, 29% of all ewes exhibited spontaneous, out-of-season ovulatory activity, with no substantial variation between the years. Significant sources of systematic variation were the ewe age and live weight, and the month of previous lambing. Older, heavier ewes, that had lambed early the previous autumn, exhibited more frequent activity. Heritability estimates were 0.216 (± 0.084 with a linear and 0.291 with a threshold model. The latter better accounts for the categorical nature of the trait. The linear model repeatability was 0.230 (± 0.095. The results obtained in this study support the notion that spontaneous out-of-season ovulatory activity can be considered in the development of a breeding plan for the Chios sheep breed.

Two types of mental fatigue affect spontaneous oscillatory brain activities in different ways

OpenAIRE

Shigihara, Yoshihito; Tanaka, Masaaki; Ishii, Akira; Kanai, Etsuko; Funakura, Masami; Watanabe, Yasuyoshi

2013-01-01

Abstract Background Fatigue has a multi-factorial nature. We examined the effects of two types of mental fatigue on spontaneous oscillatory brain activity using magnetoencephalography (MEG). Methods Participants were randomly assigned to two groups in a single-blinded, crossover fashion to perform two types of mental fatigue-inducing experiments. Each experiment consisted of a 30-min fatigue-inducing 0- or 2-back test session and two evaluation sessions performed just before and after the fat...

The potential predictability of fire danger provided by ECMWF forecast

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Di Giuseppe, Francesca

2017-04-01

The European Forest Fire Information System (EFFIS), is currently being developed in the framework of the Copernicus Emergency Management Services to monitor and forecast fire danger in Europe. The system provides timely information to civil protection authorities in 38 nations across Europe and mostly concentrates on flagging regions which might be at high danger of spontaneous ignition due to persistent drought. The daily predictions of fire danger conditions are based on the US Forest Service National Fire Danger Rating System (NFDRS), the Canadian forest service Fire Weather Index Rating System (FWI) and the Australian McArthur (MARK-5) rating systems. Weather forcings are provided in real time by the European Centre for Medium range Weather Forecasts (ECMWF) forecasting system. The global system's potential predictability is assessed using re-analysis fields as weather forcings. The Global Fire Emissions Database (GFED4) provides 11 years of observed burned areas from satellite measurements and is used as a validation dataset. The fire indices implemented are good predictors to highlight dangerous conditions. High values are correlated with observed fire and low values correspond to non observed events. A more quantitative skill evaluation was performed using the Extremal Dependency Index which is a skill score specifically designed for rare events. It revealed that the three indices were more skilful on a global scale than the random forecast to detect large fires. The performance peaks in the boreal forests, in the Mediterranean, the Amazon rain-forests and southeast Asia. The skill-scores were then aggregated at country level to reveal which nations could potentiallty benefit from the system information in aid of decision making and fire control support. Overall we found that fire danger modelling based on weather forecasts, can provide reasonable predictability over large parts of the global landmass.

Research on spontaneous activity in adult anisometropic amblyopia with regional homogeneity

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Huang, Yufeng; Zhou, Yifeng

2017-06-01

Amblyopia usually occurs in early childhood and results in monocular visual impairment. The functional magnetic resonance imaging (fMRI) studies have reflected functional anomaly in amblyopia. In resting-state fMRI study, spontaneous activity changes abnormally in anisometropic amblyopia could be revealed by the regional homogeneity (ReHo). Twenty two adult anisometropic amblyopes and Twenty one normal controls participated in this fMRI study. Two sample T test was carried out to analysis ReHo within the whole brain for the inter groups. Compare with normal group, our study found that the amblyopia’s ReHo mainly increased in the left frontal lobe, while decreased in the left cerebellum, the temporal lobe (left and right), and the left parietal lobe. And the ReHo values in middle and inferior temporal lobe, the prefrontal lobe, frontal lobe (positive) and parietal lobe and medial frontal gyrus (negative) could be correlated with the acuity deficit of amblyopia. The results increased in ReHo may indicate compensatory plasticity in higher vision information process, while the decreased in ReHo may reflect decreased ability in eye movement, spatial sense and visuo-motor coordination. The correlation revealed that the vision deficit may correspond to the spontaneous in certain brain area.

The Spontaneous Combustion of Railway Ties and Asphalt Shingles

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Leslie, Geoffrey

Many Low Carbon Fuels (LCFs) present unknown spontaneous combustion risks, which must be quantified before their use as fossil fuel replacements. Wood and coal spontaneous combustion is well understood; however, LCFs weather, and subsequent chemical changes could affect their spontaneous combustion properties. LCF spontaneous combustion could lead to accidental fires with possible loss of life, limb and property. The spontaneous combustion risks of two LCFs, discarded creosote-treated wooden railway ties and roofing asphalt shingles, were investigated with calorimetry and heat transfer experiments. Chemical changes due to weathering were studied with pyrolysis-Gas Chromatography/Mass Spectrometry (py-GC/MS). Creosote-treated wooden railway tie dust, roofing asphalt shingle particles, poplar wood pellets, and petroleum coke self-heating were studied with isothermal calorimetry. Railway tie dust and asphalt shingle heat transfer were characterized with a guarded hot plate. Petroleum coke self-heating was consistent with coal, while both poplar pellets and railway tie dust were found to be more reactive compared to oven test results of similar materials. The observed increase in reactivity was probably a result of significant moisture contenint in the pellet and railway tie dust. Critical conditions for spontaneous combustion were evaluated with the Frank-Kamenetskii parameter, assuming an ambient temperature of 40°C and constant moisture content. Kamenetskii calculations indicate that a 1.6 m cube of railway tie dust, or a 58 m cube of asphalt particles, would be unstable and combust. LCF chemistry may have been affected by weathering, which would cause chemical changes that affect their spontaneous combustion properties. Therefore, railway tie wood and roofing asphalt shingle chemistry were investigated by identifying products of 250° and 550°C pyrolysis with py-GC/MS. Railway tie wood pyrolyzates did not show signs of weathering; in contrast, asphalt pyrolysis

National and international standards and recommendations on fire protection and fire safety assessment

International Nuclear Information System (INIS)

Berg, H.P.

2007-01-01

Experience feedback from events in nuclear facilities worldwide has shown that fire can represent a safety significant hazard. Thus, the primary objectives of fire protection programmes are to minimize both the probability of occurrence and the consequences of a fire. The regulator body expects that the licensees justify their arrangements for identifying how fires can occur and spread, assess the vulnerability of plant equipment and structures, determine how the safe operation of a plant is affected, and introduce measures to prevent a fire hazard from developing and propagating as well as to mitigate its effects in case the fire cannot be prevented. For that purpose usually a comprehensive regulatory framework for fire protection has been elaborated, based on national industrial regulations, nuclear specific regulations as well as international recommendations or requirements. Examples of such national and international standards and recommendations on fire protection and fire safety assessment as well as ongoing activities in this field are described. (orig.)

Variation in soil enzyme activity as a function of vegetation amount, type, and spatial structure in fire-prone Mediterranean shrublands.

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Mayor, Ángeles G; Goirán, Silvana B; Vallejo, V Ramón; Bautista, Susana

2016-12-15

Fire-prone Mediterranean shrublands may be seriously threatened by land degradation due to progressive opening of the vegetation cover driven by increasing drought and fire recurrence. However, information about the consequences of this opening process for critical ecosystem functions is scant. In this work, we studied the influence of vegetation amount, type, and spatial pattern in the variation of extracellular soil enzyme activity (acid phosphatase, β-glucosidase, and urease) in fire-prone shrublands in eastern Spain. Soil was sampled in vegetation-patch and open-interpatch microsites in 15 shrubland sites affected by large wildfires in 1991. On average, the activities of the three enzymes were 1.5 (β-glucosidase and urease) to 1.7 (acid phosphatase) times higher in soils under vegetation patches than in adjacent interpatches. In addition, phosphatase activity for both microsites significantly decreased with the fragmentation of the vegetation. This result was attributed to a lower influence of roots -the main source of acid phosphatase- in the bigger interpatches of the sites with lower patch cover, and to feedbacks between vegetation pattern, redistribution of resources, and soil quality during post-fire vegetation dynamics. Phosphatase activity was also 1.2 times higher in patches of resprouter plants than in patches of non-resprouters, probably due to the faster post-fire recovery and older age of resprouter patches in these fire-prone ecosystems. The influence on the studied enzymes of topographic and climatic factors acting at the landscape scale was insignificant. According to our results, variations in the cover, pattern, and composition of vegetation patches may have profound impacts on soil enzyme activity and associated nutrient cycling processes in fire-prone Mediterranean shrublands, particularly in those related to phosphorus. Copyright © 2016 Elsevier B.V. All rights reserved.

Review of CNEN activities in the field of sodium fires

International Nuclear Information System (INIS)

Gerosa, A.

1979-01-01

The problems related to sodium fires have received increased attention at CNEN in recent years. Sodium fires have been reported in several countries with a rate that is. relatively high if compared to the number of plants in operation. The consequences of fires have been usually quite limited but it appears that more adequate precautions could often be applied to minimize risk of more serious consequences. Many alternatives exist for fire prevention and for fire extinction, but the fact that many alternatives have not been sufficiently tested make choices rather difficult. CNEN has been facing the problem of sodium fire prevention and extinction in relation to: design of PEC reactor; design of experimental loops in its own centres (Casaccia and Brasimone); safe operation of the same loops and analysis of accidents and potential accident situations; design of facilities for sodium fire experiments; operation of sodium fire facilities; operation of sodium disposal facilities. It is worth mentioning that sodium is also utilized by italian concerns, where it is processed mostly as an intermediate product in the manufacture of tetraethyl lead. A recent accident in a TEL production plant in Italy (Trento in July 1978) has recently once more raised the question if provisions for sodium fire extinction were adequate. Small scale fires for training purposes have been performed by several experimenters at CNEN since 1965. A more systematic approach, initiated in 1973 at Brasimone Centre, has been interrupted after 1976 when studies for the construction of a larger experimental facility (SUPERSATANA) have been abandoned. In 1976 it was proposed a CNEN participation to the French Program ESMERALDA. An accord to run the ESMERALDA Project as a French-Italian common program has recently been taken. Experimental results are presented in this paper

Review of CNEN activities in the field of sodium fires

Energy Technology Data Exchange (ETDEWEB)

Gerosa, A [CNEN/CSN Casaccia, Rome (Italy)

1979-03-01

The problems related to sodium fires have received increased attention at CNEN in recent years. Sodium fires have been reported in several countries with a rate that is. relatively high if compared to the number of plants in operation. The consequences of fires have been usually quite limited but it appears that more adequate precautions could often be applied to minimize risk of more serious consequences. Many alternatives exist for fire prevention and for fire extinction, but the fact that many alternatives have not been sufficiently tested make choices rather difficult. CNEN has been facing the problem of sodium fire prevention and extinction in relation to: design of PEC reactor; design of experimental loops in its own centres (Casaccia and Brasimone); safe operation of the same loops and analysis of accidents and potential accident situations; design of facilities for sodium fire experiments; operation of sodium fire facilities; operation of sodium disposal facilities. It is worth mentioning that sodium is also utilized by italian concerns, where it is processed mostly as an intermediate product in the manufacture of tetraethyl lead. A recent accident in a TEL production plant in Italy (Trento in July 1978) has recently once more raised the question if provisions for sodium fire extinction were adequate. Small scale fires for training purposes have been performed by several experimenters at CNEN since 1965. A more systematic approach, initiated in 1973 at Brasimone Centre, has been interrupted after 1976 when studies for the construction of a larger experimental facility (SUPERSATANA) have been abandoned. In 1976 it was proposed a CNEN participation to the French Program ESMERALDA. An accord to run the ESMERALDA Project as a French-Italian common program has recently been taken. Experimental results are presented in this paper.

Human influence on California fire regimes.

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Syphard, Alexandra D; Radeloff, Volker C; Keeley, Jon E; Hawbaker, Todd J; Clayton, Murray K; Stewart, Susan I; Hammer, Roger B

2007-07-01

Periodic wildfire maintains the integrity and species composition of many ecosystems, including the mediterranean-climate shrublands of California. However, human activities alter natural fire regimes, which can lead to cascading ecological effects. Increased human ignitions at the wildland-urban interface (WUI) have recently gained attention, but fire activity and risk are typically estimated using only biophysical variables. Our goal was to determine how humans influence fire in California and to examine whether this influence was linear, by relating contemporary (2000) and historic (1960-2000) fire data to both human and biophysical variables. Data for the human variables included fine-resolution maps of the WUI produced using housing density and land cover data. Interface WUI, where development abuts wildland vegetation, was differentiated from intermix WUI, where development intermingles with wildland vegetation. Additional explanatory variables included distance to WUI, population density, road density, vegetation type, and ecoregion. All data were summarized at the county level and analyzed using bivariate and multiple regression methods. We found highly significant relationships between humans and fire on the contemporary landscape, and our models explained fire frequency (R2 = 0.72) better than area burned (R2 = 0.50). Population density, intermix WUI, and distance to WUI explained the most variability in fire frequency, suggesting that the spatial pattern of development may be an important variable to consider when estimating fire risk. We found nonlinear effects such that fire frequency and area burned were highest at intermediate levels of human activity, but declined beyond certain thresholds. Human activities also explained change in fire frequency and area burned (1960-2000), but our models had greater explanatory power during the years 1960-1980, when there was more dramatic change in fire frequency. Understanding wildfire as a function of the

Modeling fire occurrence as a function of landscape

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Loboda, T. V.; Carroll, M.; DiMiceli, C.

2011-12-01

Wildland fire is a prominent component of ecosystem functioning worldwide. Nearly all ecosystems experience the impact of naturally occurring or anthropogenically driven fire. Here, we present a spatially explicit and regionally parameterized Fire Occurrence Model (FOM) aimed at developing fire occurrence estimates at landscape and regional scales. The model provides spatially explicit scenarios of fire occurrence based on the available records from fire management agencies, satellite observations, and auxiliary geospatial data sets. Fire occurrence is modeled as a function of the risk of ignition, potential fire behavior, and fire weather using internal regression tree-driven algorithms and empirically established, regionally derived relationships between fire occurrence, fire behavior, and fire weather. The FOM presents a flexible modeling structure with a set of internal globally available default geospatial independent and dependent variables. However, the flexible modeling environment adapts to ingest a variable number, resolution, and content of inputs provided by the user to supplement or replace the default parameters to improve the model's predictive capability. A Southern California FOM instance (SC FOM) was developed using satellite assessments of fire activity from a suite of Landsat and Moderate Resolution Imaging Spectroradiometer (MODIS) satellite data, Monitoring Trends in Burn Severity fire perimeters, and auxiliary geospatial information including land use and ownership, utilities, transportation routes, and the Remote Automated Weather Station data records. The model was parameterized based on satellite data acquired between 2001 and 2009 and fire management fire perimeters available prior to 2009. SC FOM predictive capabilities were assessed using observed fire occurrence available from the MODIS active fire product during 2010. The results show that SC FOM provides a realistic estimate of fire occurrence at the landscape level: the fraction of

Spaced sessions of avoidance extinction reduce spontaneous recovery and promote infralimbic cortex activation.

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Tapias-Espinosa, Carles; Kádár, Elisabet; Segura-Torres, Pilar

2018-01-15

Extinction-based therapies (EBT) are the psychological treatments of choice for certain anxiety disorders, such as post-traumatic stress disorder. However, some patients relapse and suffer spontaneous recovery (SR) of anxiety symptoms and persistence of avoidance behaviour, which underlines the need for improving EBT. In rats, recent evidence has highlighted the relevance of the temporal distribution of extinction sessions in reducing SR of auditory fear conditioning, although it has seldom been studied in procedures involving proactive avoidance responses, such as two-way active avoidance conditioning (TWAA). We examined whether the temporal distribution of two extinction sessions separated by 24h or 7days (contiguous versus spaced extinction paradigms, respectively), influences SR after 28days of a TWAA task. c-Fos expression, as a marker of neuronal activation, was also measured by immunohistochemistry 90min after the SR test in the amygdala and the medial prefrontal cortex. The temporal distribution of extinction sessions did not affect the degree of extinction learning. However, only the rats that underwent the 7-day spaced extinction paradigm maintained the level of extinction in the long term, showing no SR in TWAA. This behavioural finding was consistent with a greater number of c-Fos-labelled neurons in the infralimbic cortex in the 7-day group, and in the Lateral and Central nuclei of the amygdala in the 24-hour group. These findings show that a time-spaced extinction paradigm reduces the spontaneous recovery of active avoidance behaviour, and that this behavioural advantage appears to be related to the activation of the infralimbic cortex. Copyright © 2017 Elsevier B.V. All rights reserved.

Protein Phosphatase 1 Recruitment by Rif1 Regulates DNA Replication Origin Firing by Counteracting DDK Activity

Directory of Open Access Journals (Sweden)

Anoushka Davé

2014-04-01

Full Text Available The firing of eukaryotic origins of DNA replication requires CDK and DDK kinase activities. DDK, in particular, is involved in setting the temporal program of origin activation, a conserved feature of eukaryotes. Rif1, originally identified as a telomeric protein, was recently implicated in specifying replication timing in yeast and mammals. We show that this function of Rif1 depends on its interaction with PP1 phosphatases. Mutations of two PP1 docking motifs in Rif1 lead to early replication of telomeres in budding yeast and misregulation of origin firing in fission yeast. Several lines of evidence indicate that Rif1/PP1 counteract DDK activity on the replicative MCM helicase. Our data suggest that the PP1/Rif1 interaction is downregulated by the phosphorylation of Rif1, most likely by CDK/DDK. These findings elucidate the mechanism of action of Rif1 in the control of DNA replication and demonstrate a role of PP1 phosphatases in the regulation of origin firing.

Why Does Sleep Slow-Wave Activity Increase After Extended Wake? Assessing the Effects of Increased Cortical Firing During Wake and Sleep.

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Rodriguez, Alexander V; Funk, Chadd M; Vyazovskiy, Vladyslav V; Nir, Yuval; Tononi, Giulio; Cirelli, Chiara

2016-12-07

During non-rapid eye movement (NREM) sleep, cortical neurons alternate between ON periods of firing and OFF periods of silence. This bi-stability, which is largely synchronous across neurons, is reflected in the EEG as slow waves. Slow-wave activity (SWA) increases with wake duration and declines homeostatically during sleep, but the underlying mechanisms remain unclear. One possibility is neuronal "fatigue": high, sustained firing in wake would force neurons to recover with more frequent and longer OFF periods during sleep. Another possibility is net synaptic potentiation during wake: stronger coupling among neurons would lead to greater synchrony and therefore higher SWA. Here, we obtained a comparable increase in sustained firing (6 h) in cortex by: (1) keeping mice awake by exposure to novel objects to promote plasticity and (2) optogenetically activating a local population of cortical neurons at wake-like levels during sleep. Sleep after extended wake led to increased SWA, higher synchrony, and more time spent OFF, with a positive correlation between SWA, synchrony, and OFF periods. Moreover, time spent OFF was correlated with cortical firing during prior wake. After local optogenetic stimulation, SWA and cortical synchrony decreased locally, time spent OFF did not change, and local SWA was not correlated with either measure. Moreover, laser-induced cortical firing was not correlated with time spent OFF afterward. Overall, these results suggest that high sustained firing per se may not be the primary determinant of SWA increases observed after extended wake. A long-standing hypothesis is that neurons fire less during slow-wave sleep to recover from the "fatigue" accrued during wake, when overall synaptic activity is higher than in sleep. This idea, however, has rarely been tested and other factors, namely increased cortical synchrony, could explain why sleep slow-wave activity (SWA) is higher after extended wake. We forced neurons in the mouse cortex to fire

Synoptic-scale fire weather conditions in Alaska

Science.gov (United States)

Hayasaka, Hiroshi; Tanaka, Hiroshi L.; Bieniek, Peter A.

2016-09-01

Recent concurrent widespread fires in Alaska are evaluated to assess their associated synoptic-scale weather conditions. Several periods of high fire activity from 2003 to 2015 were identified using Moderate Resolution Imaging Spectroradiometer (MODIS) hotspot data by considering the number of daily hotspots and their continuity. Fire weather conditions during the top six periods of high fire activity in the fire years of 2004, 2005, 2009, and 2015 were analyzed using upper level (500 hPa) and near surface level (1000 hPa) atmospheric reanalysis data. The top four fire-periods occurred under similar unique high-pressure fire weather conditions related to Rossby wave breaking (RWB). Following the ignition of wildfires, fire weather conditions related to RWB events typically result in two hotspot peaks occurring before and after high-pressure systems move from south to north across Alaska. A ridge in the Gulf of Alaska resulted in southwesterly wind during the first hotspot peak. After the high-pressure system moved north under RWB conditions, the Beaufort Sea High developed and resulted in relatively strong easterly wind in Interior Alaska and a second (largest) hotspot peak during each fire period. Low-pressure-related fire weather conditions occurring under cyclogenesis in the Arctic also resulted in high fire activity under southwesterly wind with a single large hot-spot peak.

Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI.

Science.gov (United States)

Fox, Michael D; Qian, Tianyi; Madsen, Joseph R; Wang, Danhong; Li, Meiling; Ge, Manling; Zuo, Huan-Cong; Groppe, David M; Mehta, Ashesh D; Hong, Bo; Liu, Hesheng

2016-01-01

Noninvasive localization of brain function is used to understand and treat neurological disease, exemplified by pre-operative fMRI mapping prior to neurosurgical intervention. The principal approach for generating these maps relies on brain responses evoked by a task and, despite known limitations, has dominated clinical practice for over 20years. Recently, pre-operative fMRI mapping based on correlations in spontaneous brain activity has been demonstrated, however this approach has its own limitations and has not seen widespread clinical use. Here we show that spontaneous and task-based mapping can be performed together using the same pre-operative fMRI data, provide complimentary information relevant for functional localization, and can be combined to improve identification of eloquent motor cortex. Accuracy, sensitivity, and specificity of our approach are quantified through comparison with electrical cortical stimulation mapping in eight patients with intractable epilepsy. Broad applicability and reproducibility of our approach are demonstrated through prospective replication in an independent dataset of six patients from a different center. In both cohorts and every individual patient, we see a significant improvement in signal to noise and mapping accuracy independent of threshold, quantified using receiver operating characteristic curves. Collectively, our results suggest that modifying the processing of fMRI data to incorporate both task-based and spontaneous activity significantly improves functional localization in pre-operative patients. Because this method requires no additional scan time or modification to conventional pre-operative data acquisition protocols it could have widespread utility. Copyright © 2015. Published by Elsevier Inc.

Characterization of indoor and outdoor pool fires with active calorimetry

International Nuclear Information System (INIS)

Koski, J.A.; Gill, W.; Gritzo, L.A.; Kent, L.A.; Wix, S.D.

1994-01-01

A water cooled, 1 m x 1 m, vertical calorimeter panel has been used in conjunction with other fire diagnostics to characterize a 6 m x 6 m outdoor and three 3 m x 3 m indoor JP-4 pool fires. Measurements reported include calorimeter surface heat flux and surface temperatures, flame temperatures, and gas flow velocities in the fire. From the data, effective radiative absorption coefficients for various zones in the fires have been estimated. The outdoor test was conducted at Sandia's Coyote Canyon test facility, while indoor tests were conducted at the indoor SMokE Reduction Facility (SMERF) at the same location. The measurements provide data useful in calibrating simple analytic fire models intended for the analysis of packages containing hazardous materials

Cortical Network Models of Firing Rates in the Resting and Active States Predict BOLD Responses.

Directory of Open Access Journals (Sweden)

Maxwell R Bennett

Full Text Available Measurements of blood oxygenation level dependent (BOLD signals have produced some surprising observations. One is that their amplitude is proportional to the entire activity in a region of interest and not just the fluctuations in this activity. Another is that during sleep and anesthesia the average BOLD correlations between regions of interest decline as the activity declines. Mechanistic explanations of these phenomena are described here using a cortical network model consisting of modules with excitatory and inhibitory neurons, taken as regions of cortical interest, each receiving excitatory inputs from outside the network, taken as subcortical driving inputs in addition to extrinsic (intermodular connections, such as provided by associational fibers. The model shows that the standard deviation of the firing rate is proportional to the mean frequency of the firing when the extrinsic connections are decreased, so that the mean BOLD signal is proportional to both as is observed experimentally. The model also shows that if these extrinsic connections are decreased or the frequency of firing reaching the network from the subcortical driving inputs is decreased, or both decline, there is a decrease in the mean firing rate in the modules accompanied by decreases in the mean BOLD correlations between the modules, consistent with the observed changes during NREM sleep and under anesthesia. Finally, the model explains why a transient increase in the BOLD signal in a cortical area, due to a transient subcortical input, gives rises to responses throughout the cortex as observed, with these responses mediated by the extrinsic (intermodular connections.

The economics of fire protection

CERN Document Server

Ramachandran, Ganapathy

2003-01-01

This important new book, the first of its kind in the fire safety field, discusses the economic problems faced by decision-makers in the areas of fire safety and fire precautions. The author considers the theoretical aspects of cost-benefit analysis and other relevant economic problems with practical applications to fire protection systems. Clear examples are included to illustrate these techniques in action. The work covers: * the performance and effectiveness of passive fire protection measures such as structural fire resistance and means of escape facilities, and active systems such as sprinklers and detectors * the importance of educating for better understanding and implementation of fire prevention through publicity campaigns and fire brigade operations * cost-benefit analysis of fire protection measures and their combinations, taking into account trade-offs between these measures. The book is essential reading for consultants and academics in construction management, economics and fire safety, as well ...

Urethane anesthesia depresses activities of thalamocortical neurons and alters its response to nociception in terms of dual firing modes

Directory of Open Access Journals (Sweden)

Yeowool eHuh

2013-10-01

Full Text Available Anesthetics are often used to characterize the activity of single neurons in-vivo for its advantages such as reduced noise level and convenience in noxious stimulations. Of the anesthetics, urethane had been widely used in some thalamic studies under the assumption that sensory signals are still relayed to the thalamus under urethane anesthesia and that thalamic response would therefore reflect the response of the awake state. We tested whether this assumption stands by comparing thalamic activity in terms of tonic and burst firing modes during ‘the awake state’ or under ‘urethane anesthesia’ utilizing the extracellular single unit recording technique. First we have tested how thalamic relay neurons respond to the introduction of urethane and then tested how urethane influences thalamic discharges under formalin-induced nociception. Urethane significantly depressed overall firing rates of thalamic relay neurons, which was sustained despite the delayed increase of burst activity over the 4 hour recording period. Thalamic response to nociception under anesthesia was also similar overall except for the slight and transient increase of burst activity. Overall, results demonstrated that urethane suppresses the activity of thalamic relay neurons and that, despite the slight fluctuation of burst firing, formalin-induced nociception cannot significantly change the firing pattern of thalamic relay neurons that was caused by urethane.

Remotely-sensed active fire data for protected area management: eight-year patterns in the Manas National Park, India.

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Takahata, Chihiro; Amin, Rajan; Sarma, Pranjit; Banerjee, Gitanjali; Oliver, William; Fa, John E

2010-02-01

The Terai-Duar savanna and grasslands, which once extended along most of the Himalayan foothills, now only remain in a number of protected areas. Within these localities, grassland burning is a major issue, but data on frequency and distribution of fires are limited. Here, we analysed the incidence of active fires, which only occur during the dry season (Nov.-Mar.), within a significant area of Terai grasslands: the Manas National Park (MNP), India. We obtained locations of 781 fires during the 2000-2008 dry seasons, from the Fire Information for Resource Management System (FIRMS) that delivers global MODIS hotspot/fire locations using remote sensing and GIS technologies. Annual number of fires rose significantly from around 20 at the start of the study period to over 90 after 2002, with most (85%) detected between December and January. Over half of the fires occurred in tall grasslands, but fire density was highest in wetland and riverine vegetation, dry at the time. Most burning took place near rivers, roads and the park boundary, suggesting anthropogenic origins. A kernel density map of all recorded fires indicated three heavily burnt areas in the MNP, all within the tall grasslands. Our study demonstrates, despite some technical caveats linked to fire detection technology, which is improving, that remote fire data can be a practical tool in understanding fire concentration and burning temporal patterns in highly vulnerable habitats, useful in guiding management.

An empirical machine learning method for predicting potential fire control locations for pre-fire planning and operational fire management

Science.gov (United States)

Christopher D. O' Connor; David E. Calkin; Matthew P. Thompson

2017-01-01

During active fire incidents, decisions regarding where and how to safely and effectively deploy resources to meet management objectives are often made under rapidly evolving conditions, with limited time to assess management strategies or for development of backup plans if initial efforts prove unsuccessful. Under all but the most extreme fire weather conditions,...

Excellent c-Si surface passivation by thermal atomic layer deposited aluminum oxide after industrial firing activation

International Nuclear Information System (INIS)

Liao, B; Stangl, R; Ma, F; Mueller, T; Lin, F; Aberle, A G; Bhatia, C S; Hoex, B

2013-01-01

We demonstrate that by using a water (H 2 O)-based thermal atomic layer deposited (ALD) aluminum oxide (Al 2 O 3 ) film, excellent surface passivation can be attained on planar low-resistivity silicon wafers. Effective carrier lifetime values of up to 12 ms and surface recombination velocities as low as 0.33 cm s −1 are achieved on float-zone wafers after a post-deposition thermal activation of the Al 2 O 3 passivation layer. This post-deposition activation is achieved using an industrial high-temperature firing process which is commonly used for contact formation of standard screen-printed silicon solar cells. Neither a low-temperature post-deposition anneal nor a silicon nitride capping layer is required in this case. Deposition temperatures in the 100–400 °C range and peak firing temperatures of about 800 °C (set temperature) are investigated. Photoluminescence imaging shows that the surface passivation is laterally uniform. Corona charging and capacitance–voltage measurements reveal that the negative fixed charge density near the AlO x /c-Si interface increases from 1.4 × 10 12 to 3.3 × 10 12 cm −2 due to firing, while the midgap interface defect density reduces from 3.3 × 10 11 to 0.8 × 10 11 cm −2 eV −1 . This work demonstrates that direct firing activation of thermal ALD Al 2 O 3 is feasible, which could be beneficial for solar cell manufacturing. (paper)

Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA

International Nuclear Information System (INIS)

Hastings, P.J.; Quah, S.-K.; Borstel, R.C. von

1976-01-01

It is stated that strains of yeast carrying mutations in many of the steps in pathways repairing radiation-induced damage to DNA have enhanced spontaneous mutation rates. Most strains isolated because they have enhanced spontaneous mutation carry mutations in DNA repair systems. This suggests that much spontaneous mutation arises by mutagenic repair of spontaneous lesions. (author)

Idaho National Engineering and Environmental Laboratory Wildland Fire Management Environmental Assessment

Energy Technology Data Exchange (ETDEWEB)

Irving, John S

2003-04-01

DOE prepared an environmental assessment (EA)for wildland fire management activities on the Idaho National Engineering and Environmental Laboratory (INEEL) (DOE/EA-1372). The EA was developed to evaluate wildland fire management options for pre-fire, fire suppression, and post fire activities. Those activities have an important role in minimizing the conversion of the native sagebrush steppe ecosystem found on the INEEL to non-native weeds. Four alternative management approaches were analyzed: Alternative 1 - maximum fire protection; Alternative 2 - balanced fire protection; Alternative 2 - balanced fire protection; Alternative 3 - protect infrastructure and personnel; and Alternative 4 - no action/traditional fire protection.

Salicylate-induced changes in spontaneous activity of single units in the inferior colliculus of the guinea pig.

Science.gov (United States)

Jastreboff, P J; Sasaki, C T

1986-11-01

Changes in spontaneous neuronal activity of the inferior colliculus in albino guinea pigs before and after administration of sodium salicylate were analyzed. Animals were anesthetized with pentobarbital, and two microelectrodes separated by a few hundred microns were driven through the inferior colliculus. After collecting a sufficiently large sample of cells, sodium salicylate (450 mg/kg) was injected i.p. and recordings again made 2 h after the injection. Comparison of spontaneous activity recorded before and after salicylate administration revealed highly statistically significant differences (p less than 0.001). After salicylate, the mean rate of the cell population increased from 29 to 83 Hz and the median from 26 to 74 Hz. Control experiments in which sodium salicylate was replaced by saline injection revealed no statistically significant differences in cell discharges. Recordings made during the same experiments from lobulus V of the cerebellar vermis revealed no changes in response to salicylate. The observed changes in single-unit activity due to salicylate administration may represent the first systematic evidence of a tinnituslike phenomenon in animals.

Reduced frequency and severity of residential fires following delivery of fire prevention education by on-duty fire fighters: cluster randomized controlled study.

Science.gov (United States)

Clare, Joseph; Garis, Len; Plecas, Darryl; Jennings, Charles

2012-04-01

In 2008, Surrey Fire Services, British Columbia, commenced a firefighter-delivered, door-to-door fire-prevention education and smoke alarm examination/installation initiative with the intention of reducing the frequency and severity of residential structure fires in the City of Surrey. High-risk zones within the city were identified and 18,473 home visits were undertaken across seven temporal delivery cohorts (13.8% of non-apartment dwellings in the city). The frequency and severity of fires pre- and post- the home visit intervention was examined in comparison to randomized high-risk cluster controls. Overall, the frequency of fires was found to have reduced in the city overall, however, the reduction in the intervention cohorts was significantly larger than for controls. Furthermore, when fires did occur within the intervention cohorts, smoke detectors were activated more frequently and the fires were confined to the object of origin more often post-home visits. No equivalent pattern was observed for the cluster control. On-duty fire fighters can reduce the frequency and severity of residential fires through targeted, door-to-door distribution of fire prevention education in high-risk areas. Copyright © 2012 Elsevier Ltd. All rights reserved.

Temporal scaling behavior of forest and urban fires

Science.gov (United States)

Wang, J.; Song, W.; Zheng, H.; Telesca, L.

2009-04-01

It has been found that many natural systems are characterized by scaling behavior. In such systems natural factors dominate the event dynamics. Forest fires in different countries have been found to exhibit frequency-size power law over many orders of magnitude and with similar value of parameters. But in countries with high population density such as China and Japan, more than 95% of the forest fire disasters are caused by human activities. Furthermore, with the development of society, the wildland-urban interface (WUI) area is becoming more and more populated, and the forest fire is much connected with urban fire. Therefore exploring the scaling behavior of fires dominated by human-related factors is very challenging. The present paper explores the temporal scaling behavior of forest fires and urban fires in Japan with mathematical methods. Two factors, Allan factor (AF) and Fano factor (FF) are used to investigate time-scaling of fire systems. It is found that the FF for both forest fires and urban fires increases linearly in log-log scales, and this indicates that it behaves as a power-law for all the investigated timescales. From the AF plot a 7 days cycle is found, which indicates a weekly cycle. This may be caused by human activities which has a weekly periodicity because on weekends people usually have more outdoor activities, which may cause more hidden trouble of fire disasters. Our findings point out that although the human factors are the main cause, both the forest fires and urban fires exhibit time-scaling behavior. At the same time, the scaling exponents for urban fires are larger than forest fires, signifying a more intense clustering. The reason may be that fires are affected not only by weather condition, but also by human activities, which play a more important role for urban fires than forest fires and have a power law distribution and scaling behavior. Then some work is done to the relative humidity. Similar distribution law characterizes the

Manual fire fighting tactics at Nuclear Power Plant

International Nuclear Information System (INIS)

Jee, Moon Hak; Moon, Chan Kook

2012-01-01

The general requirements of fire protection at nuclear power plant (NPP) are fire protection program, fire hazard analysis, and fire prevention features. In addition, specific fire protection requirements such as water supplies, fire detection, fire protection of safe related equipment, and safe shutdown capabilities must be provided. Particularly, manual fire fighting is required as specific requirements with the provisions to secure manual fire suppression, fire brigade and its training, and administrative controls for manual fire fighting. If a fire is alarmed and confirmed to be a real fire, the fire brigade must take manual fire fighting activities as requested at fire protection program. According to the present requirements in itself, there is not any specific manual fire fighting ways or practical strategies. In general, fire zones or compartments at NPPs are built in a confined condition. In theory, the fire condition will change from a combustible-controlled fire to a ventilation-governing fire with the time duration. In case of pool fire with the abundant oxygen and flammable liquid, it can take just a few minutes for the flash-over to occur. For the well-confined fire zone, it will change from a flame fire to a smoldering state before the entrance door is opened by the fire brigade. In this context, the manual fire fighting activities must be based on a quantitative analysis and a fire risk evaluation. At this paper, it was suggested that the fire zones at NPPs should be grouped on the inherent functions and fire characteristics. Based on the fire risk characteristics and the fire zone grouping, the manual fire fighting tactics are suggested as an advanced fire fighting solution

Measurement of inter- and intra-annual variability of landscape fire activity at a continental scale: The Australian case

Science.gov (United States)

Grant J. Williamson; Lynda D. Prior; Matt Jolly; Mark A. Cochrane; Brett P. Murphy; David M. J. S. Bowman

2016-01-01

Climate dynamics at diurnal, seasonal and inter-annual scales shape global fire activity, although difficulties of assembling reliable fire and meteorological data with sufficient spatio-temporal resolution have frustrated quantification of this variability. Using Australia as a case study, we combine data from 4760 meteorological stations with 12 years of satellite-...

Delay-induced diversity of firing behavior and ordered chaotic firing in adaptive neuronal networks

International Nuclear Information System (INIS)

Gong Yubing; Wang Li; Xu Bo

2012-01-01

In this paper, we study the effect of time delay on the firing behavior and temporal coherence and synchronization in Newman–Watts thermosensitive neuron networks with adaptive coupling. At beginning, the firing exhibit disordered spiking in absence of time delay. As time delay is increased, the neurons exhibit diversity of firing behaviors including bursting with multiple spikes in a burst, spiking, bursting with four, three and two spikes, firing death, and bursting with increasing amplitude. The spiking is the most ordered, exhibiting coherence resonance (CR)-like behavior, and the firing synchronization becomes enhanced with the increase of time delay. As growth rate of coupling strength or network randomness increases, CR-like behavior shifts to smaller time delay and the synchronization of firing increases. These results show that time delay can induce diversity of firing behaviors in adaptive neuronal networks, and can order the chaotic firing by enhancing and optimizing the temporal coherence and enhancing the synchronization of firing. However, the phenomenon of firing death shows that time delay may inhibit the firing of adaptive neuronal networks. These findings provide new insight into the role of time delay in the firing activity of adaptive neuronal networks, and can help to better understand the complex firing phenomena in neural networks.

49 CFR 193.2611 - Fire protection.

Science.gov (United States)

2010-10-01

... 49 Transportation 3 2010-10-01 2010-10-01 false Fire protection. 193.2611 Section 193.2611 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...: FEDERAL SAFETY STANDARDS Maintenance § 193.2611 Fire protection. (a) Maintenance activities on fire...

Effects of high-frequency stimulation of the internal pallidal segment on neuronal activity in the thalamus in parkinsonian monkeys

Science.gov (United States)

Kammermeier, Stefan; Pittard, Damien; Hamada, Ikuma

2016-01-01

Deep brain stimulation of the internal globus pallidus (GPi) is a major treatment for advanced Parkinson's disease. The effects of this intervention on electrical activity patterns in targets of GPi output, specifically in the thalamus, are poorly understood. The experiments described here examined these effects using electrophysiological recordings in two Rhesus monkeys rendered moderately parkinsonian through treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), after sampling control data in the same animals. Analysis of spontaneous spiking activity of neurons in the basal ganglia-receiving areas of the ventral thalamus showed that MPTP-induced parkinsonism is associated with a reduction of firing rates of segments of the data that contained neither bursts nor decelerations, and with increased burst firing. Spectral analyses revealed an increase of power in the 3- to 13-Hz band and a reduction in the γ-range in the spiking activity of these neurons. Electrical stimulation of the ventrolateral motor territory of GPi with macroelectrodes, mimicking deep brain stimulation in parkinsonian patients (bipolar electrodes, 0.5 mm intercontact distance, biphasic stimuli, 120 Hz, 100 μs/phase, 200 μA), had antiparkinsonian effects. The stimulation markedly reduced oscillations in thalamic firing in the 13- to 30-Hz range and uncoupled the spiking activity of recorded neurons from simultaneously recorded local field potential (LFP) activity. These results confirm that oscillatory and nonoscillatory characteristics of spontaneous activity in the basal ganglia receiving ventral thalamus are altered in MPTP-induced parkinsonism. Electrical stimulation of GPi did not entrain thalamic activity but changed oscillatory activity in the ventral thalamus and altered the relationship between spikes and simultaneously recorded LFPs. PMID:27683881

Sodium fires in nuclear facilities

International Nuclear Information System (INIS)

Menzenhauer, P.

1974-01-01

The work deals with the behaviour of liquid sodium when it comes into contact with air, especially in the course of fires in technical plants. The most important fire procedures are constructed as realistically as possible, that is to say that the fires were not only carried out on a laboratory scale but with quantities of up to 200 kg sodium at temperatures of up to 800 0 C. The following was investigated: 1) the course of the fire in rooms, 2) restriction of the fire, 3) removal of the burnt remains, 4) protection measures. The fire was varied in its most important physical appearance such as surface fire, spurt fire and fire on isolated pipe lines. The fires were checked by precautionary, contructive measures - it was not necessary to place persons at the site of the fire - and by active measures such as for example by covering with extinguishing powder. All important test phases were captured in film and slides series. Visible material is thus available for the operation team of sodium plants and fire brigades who might possibly be called upon. (orig./LH) [de

Activation of Akt/FKHR in the medulla oblongata contributes to spontaneous respiratory recovery after incomplete spinal cord injury in adult rats.

Science.gov (United States)

Felix, M S; Bauer, S; Darlot, F; Muscatelli, F; Kastner, A; Gauthier, P; Matarazzo, V

2014-09-01

After incomplete spinal cord injury (SCI), patients and animals may exhibit some spontaneous functional recovery which can be partly attributed to remodeling of injured neural circuitry. This post-lesion plasticity implies spinal remodeling but increasing evidences suggest that supraspinal structures contribute also to the functional recovery. Here we tested the hypothesis that partial SCI may activate cell-signaling pathway(s) at the supraspinal level and that this molecular response may contribute to spontaneous recovery. With this aim, we used a rat model of partial cervical hemisection which injures the bulbospinal respiratory tract originating from the medulla oblongata of the brainstem but leads to a time-dependent spontaneous functional recovery of the paralyzed hemidiaphragm. We first demonstrate that after SCI the PI3K/Akt signaling pathway is activated in the medulla oblongata of the brainstem, resulting in an inactivation of its pro-apoptotic downstream target, forkhead transcription factor (FKHR/FOXO1A). Retrograde labeling of medullary premotoneurons including respiratory ones which project to phrenic motoneurons reveals an increased FKHR phosphorylation in their cell bodies together with an unchanged cell number. Medulla infusion of the PI3K inhibitor, LY294002, prevents the SCI-induced Akt and FKHR phosphorylations and activates one of its death-promoting downstream targets, Fas ligand. Quantitative EMG analyses of diaphragmatic contractility demonstrate that the inhibition of medulla PI3K/Akt signaling prevents spontaneous respiratory recovery normally observed after partial cervical SCI. Such inhibition does not however affect either baseline contractile frequency or the ventilatory reactivity under acute respiratory challenge. Together, these findings provide novel evidence of supraspinal cellular contribution to the spontaneous respiratory recovery after partial SCI. Copyright © 2014 Elsevier Inc. All rights reserved.

Hydrodynamic interaction induced spontaneous rotation of coupled active filaments.

Science.gov (United States)

Jiang, Huijun; Hou, Zhonghuai

2014-12-14

We investigate the coupled dynamics of active filaments with long range hydrodynamic interactions (HI). Remarkably, we find that filaments can rotate spontaneously under the same conditions in which a single filament alone can only move in translation. Detailed analysis reveals that the emergence of coupled rotation originates from an asymmetric flow field associated with HI which breaks the symmetry of translational motion when filaments approach. The breaking is then further stabilized by HI to form self-sustained coupled rotation. Intensive simulations show that coupled rotation forms easily when one filament tends to collide with the front-half of the other. For head-to-tail approaching, we observe another interesting HI-induced coupled motion, where filaments move together in the form of one following the other. Moreover, the radius of coupled rotation increases exponentially as the rigidity of the filament increases, which suggests that HI are also important for the alignment of rigid-rod-like filaments which has been assumed to be solely a consequence of direct collisions.

National Fire News- Current Wildfires

Science.gov (United States)

... 1 to 5) Current hours for the National Fire Information Center are (MST) 8:00 am - 4: ... for more information. June 15, 2018 Nationally, wildland fire activity remains about average for this time of ...

Multichannel detrended fluctuation analysis reveals synchronized patterns of spontaneous spinal activity in anesthetized cats.

Directory of Open Access Journals (Sweden)

Erika E Rodríguez

Full Text Available The analysis of the interaction and synchronization of relatively large ensembles of neurons is fundamental for the understanding of complex functions of the nervous system. It is known that the temporal synchronization of neural ensembles is involved in the generation of specific motor, sensory or cognitive processes. Also, the intersegmental coherence of spinal spontaneous activity may indicate the existence of synaptic neural pathways between different pairs of lumbar segments. In this study we present a multichannel version of the detrended fluctuation analysis method (mDFA to analyze the correlation dynamics of spontaneous spinal activity (SSA from time series analysis. This method together with the classical detrended fluctuation analysis (DFA were used to find out whether the SSA recorded in one or several segments in the spinal cord of the anesthetized cat occurs either in a random or in an organized manner. Our results are consistent with a non-random organization of the sets of neurons involved in the generation of spontaneous cord dorsum potentials (CDPs recorded either from one lumbar segment (DFA-α mean = 1.04[Formula: see text]0.09 or simultaneously from several lumbar segments (mDFA-α mean = 1.01[Formula: see text]0.06, where α = 0.5 indicates randomness while α = 0.5 indicates long-term correlations. To test the sensitivity of the mDFA method we also examined the effects of small spinal lesions aimed to partially interrupt connectivity between neighboring lumbosacral segments. We found that the synchronization and correlation between the CDPs recorded from the L5 and L6 segments in both sides of the spinal cord were reduced when a lesion comprising the left dorsal quadrant was performed between the segments L5 and L6 (mDFA-[Formula: see text] = 0.992 as compared to initial conditions mDFA-α = 1.186. The synchronization and correlation were reduced even further after a similar additional right spinal lesion (mDFA-α = 0

Contributions of microbial activity and ash deposition to post-fire nitrogen availability in a pine savanna

Science.gov (United States)

Ficken, Cari D.; Wright, Justin P.

2017-01-01

Many ecosystems experience drastic changes to soil nutrient availability associated with fire, but the magnitude and duration of these changes are highly variable among vegetation and fire types. In pyrogenic pine savannas across the southeastern United States, pulses of soil inorganic nitrogen (N) occur in tandem with ecosystem-scale nutrient losses from prescribed burns. Despite the importance of this management tool for restoring and maintaining fire-dependent plant communities, the contributions of different mechanisms underlying fire-associated changes to soil N availability remain unclear. Pulses of N availability following fire have been hypothesized to occur through (1) changes to microbial cycling rates and (2) direct ash deposition. Here, we document fire-associated changes to N availability across the growing season in a longleaf pine savanna in North Carolina. To differentiate between possible mechanisms driving soil N pulses, we measured net microbial cycling rates and changes to soil δ15N before and after a burn. Our findings refute both proposed mechanisms: we found no evidence for changes in microbial activity, and limited evidence that ash deposition could account for the increase in ammonium availability to more than 5-25 times background levels. Consequently, we propose a third mechanism to explain post-fire patterns of soil N availability, namely that (3) changes to plant sink strength may contribute to ephemeral increases in soil N availability, and encourage future studies to explicitly test this mechanism.

Adapting fire management to future fire regimes: impacts on boreal forest composition and carbon balance in Canadian National Parks

Science.gov (United States)

de Groot, W. J.; Flannigan, M. D.; Cantin, A.

2009-04-01

The effects of future fire regimes altered by climate change, and fire management in adaptation to climate change were studied in the boreal forest region of western Canada. Present (1975-90) and future (2080-2100) fire regimes were simulated for several National Parks using data from the Canadian (CGCM1) and Hadley (HadCM3) Global Climate Models (GCM) in separate simulation scenarios. The long-term effects of the different fire regimes on forests were simulated using a stand-level, boreal fire effects model (BORFIRE). Changes in forest composition and biomass storage due to future altered fire regimes were determined by comparing current and future simulation results. This was used to assess the ecological impact of altered fire regimes on boreal forests, and the future role of these forests as carbon sinks or sources. Additional future simulations were run using adapted fire management strategies, including increased fire suppression and the use of prescribed fire to meet fire cycle objectives. Future forest composition, carbon storage and emissions under current and adapted fire management strategies were also compared to determine the impact of various future fire management options. Both of the GCM's showed more severe burning conditions under future fire regimes. This includes fires with higher intensity, greater depth of burn, greater total fuel consumption and shorter fire cycles (or higher rates of annual area burned). The Canadian GCM indicated burning conditions more severe than the Hadley GCM. Shorter fire cycles of future fire regimes generally favoured aspen, birch, and jack pine because it provided more frequent regeneration opportunity for these pioneer species. Black spruce was only minimally influenced by future fire regimes, although white spruce declined sharply. Maintaining representation of pure and mixed white spruce ecosystems in natural areas will be a concern under future fire regimes. Active fire suppression is required in these areas. In

Climate change and future fire regimes: Examples from California

Science.gov (United States)

Keeley, Jon E.; Syphard, Alexandra D.

2016-01-01

Climate and weather have long been noted as playing key roles in wildfire activity, and global warming is expected to exacerbate fire impacts on natural and urban ecosystems. Predicting future fire regimes requires an understanding of how temperature and precipitation interact to control fire activity. Inevitably this requires historical analyses that relate annual burning to climate variation. Fuel structure plays a critical role in determining which climatic parameters are most influential on fire activity, and here, by focusing on the diversity of ecosystems in California, we illustrate some principles that need to be recognized in predicting future fire regimes. Spatial scale of analysis is important in that large heterogeneous landscapes may not fully capture accurate relationships between climate and fires. Within climatically homogeneous subregions, montane forested landscapes show strong relationships between annual fluctuations in temperature and precipitation with area burned; however, this is strongly seasonal dependent; e.g., winter temperatures have very little or no effect but spring and summer temperatures are critical. Climate models that predict future seasonal temperature changes are needed to improve fire regime projections. Climate does not appear to be a major determinant of fire activity on all landscapes. Lower elevations and lower latitudes show little or no increase in fire activity with hotter and drier conditions. On these landscapes climate is not usually limiting to fires but these vegetation types are ignition-limited. Moreover, because they are closely juxtaposed with human habitations, fire regimes are more strongly controlled by other direct anthropogenic impacts. Predicting future fire regimes is not rocket science; it is far more complicated than that. Climate change is not relevant to some landscapes, but where climate is relevant, the relationship will change due to direct climate effects on vegetation trajectories, as well as

Climate Change and Future Fire Regimes: Examples from California

Directory of Open Access Journals (Sweden)

Jon E. Keeley

2016-08-01

Full Text Available Climate and weather have long been noted as playing key roles in wildfire activity, and global warming is expected to exacerbate fire impacts on natural and urban ecosystems. Predicting future fire regimes requires an understanding of how temperature and precipitation interact to control fire activity. Inevitably this requires historical analyses that relate annual burning to climate variation. Fuel structure plays a critical role in determining which climatic parameters are most influential on fire activity, and here, by focusing on the diversity of ecosystems in California, we illustrate some principles that need to be recognized in predicting future fire regimes. Spatial scale of analysis is important in that large heterogeneous landscapes may not fully capture accurate relationships between climate and fires. Within climatically homogeneous subregions, montane forested landscapes show strong relationships between annual fluctuations in temperature and precipitation with area burned; however, this is strongly seasonal dependent; e.g., winter temperatures have very little or no effect but spring and summer temperatures are critical. Climate models that predict future seasonal temperature changes are needed to improve fire regime projections. Climate does not appear to be a major determinant of fire activity on all landscapes. Lower elevations and lower latitudes show little or no increase in fire activity with hotter and drier conditions. On these landscapes climate is not usually limiting to fires but these vegetation types are ignition-limited. Moreover, because they are closely juxtaposed with human habitations, fire regimes are more strongly controlled by other direct anthropogenic impacts. Predicting future fire regimes is not rocket science; it is far more complicated than that. Climate change is not relevant to some landscapes, but where climate is relevant, the relationship will change due to direct climate effects on vegetation

Integrated active fire retrievals and biomass burning emissions using complementary near-coincident ground, airborne and spaceborne sensor data

Science.gov (United States)

Wilfrid Schroeder; Evan Ellicott; Charles Ichoku; Luke Ellison; Matthew B. Dickinson; Roger D. Ottmar; Craig Clements; Dianne Hall; Vincent Ambrosia; Robert. Kremens

2013-01-01

Ground, airborne and spaceborne data were collected for a 450 ha prescribed fire implemented on 18 October 2011 at the Henry W. Coe State Park in California. The integration of various data elements allowed near-coincident active fire retrievals to be estimated. The Autonomous Modular Sensor-Wildfire (AMS) airborne multispectral imaging system was used as a bridge...

German data for risk based fire safety assessment

International Nuclear Information System (INIS)

Roewekamp, M.; Berg, H.P.

1998-01-01

Different types of data are necessary to perform risk based fire safety assessments and, in particular, to quantify the fire event tree considering the plant specific conditions. Data on fire barriers, fire detection and extinguishing, including also data on secondary effects of a fire, have to be used for quantifying the potential hazard and damage states. The existing German database on fires in nuclear power plants (NPPs) is very small. Therefore, in general generic data, mainly from US databases, are used for risk based safety assessments. Due to several differences in the plant design and conditions generic data can only be used as conservative assumptions. World-wide existing generic data on personnel failures in case of fire fighting have only to be adapted to the plant specific conditions inside the NPP to be investigated. In contrary, unavailabilities of fire barrier elements may differ strongly depending on different standards, testing requirements, etc. In addition, the operational behaviour of active fire protection equipment may vary depending on type and manufacturer. The necessity for more detailed and for additional plant specific data was the main reason for generating updated German data on the operational behaviour of active fire protection equipment/features in NPPs to support risk based fire safety analyses being recommended to be carried out as an additional tool to deterministic fire hazard analyses in the frame of safety reviews. The results of these investigations revealed a broader and more realistic database for technical reliability of active fire protection means, but improvements as well as collection of further data are still necessary. (author)

Synchronous fire activity in the tropical high Andes: an indication of regional climate forcing

NARCIS (Netherlands)

Roman-Cuesta, R.M.; Carmona-Moreno, C.; Lizcano, G.; New, M.; Silman, M.R.; Knoke, T.; Malhi, Y.; Oliveras Menor, I.; Asbjornsen, H.; Vuille, M.

2014-01-01

Global climate models suggest enhanced warming of the tropical mid and upper troposphere, with larger temperature rise rates at higher elevations. Changes in fire activity are amongst the most significant ecological consequences of rising temperatures and changing hydrological properties in

Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells

Directory of Open Access Journals (Sweden)

Giorgio Grasselli

2016-03-01

Full Text Available The plasticity of intrinsic excitability has been described in several types of neurons, but the significance of non-synaptic mechanisms in brain plasticity and learning remains elusive. Cerebellar Purkinje cells are inhibitory neurons that spontaneously fire action potentials at high frequencies and regulate activity in their target cells in the cerebellar nuclei by generating a characteristic spike burst-pause sequence upon synaptic activation. Using patch-clamp recordings from mouse Purkinje cells, we find that depolarization-triggered intrinsic plasticity enhances spike firing and shortens the duration of spike pauses. Pause plasticity is absent from mice lacking SK2-type potassium channels (SK2−/− mice and in occlusion experiments using the SK channel blocker apamin, while apamin wash-in mimics pause reduction. Our findings demonstrate that spike pauses can be regulated through an activity-dependent, exclusively non-synaptic, SK2 channel-dependent mechanism and suggest that pause plasticity—by altering the Purkinje cell output—may be crucial to cerebellar information storage and learning.

ESTIMATION OF NEAR SUBSURFACE COAL FIRE GAS EMISSIONS BASED ON GEOPHYSICAL INVESTIGATIONS

Science.gov (United States)

Chen-Brauchler, D.; Meyer, U.; Schlömer, S.; Kus, J.; Gundelach, V.; Wuttke, M.; Fischer, C.; Rueter, H.

2009-12-01

Spontaneous and industrially caused subsurface coal fires are worldwide disasters that destroy coal resources, cause air pollution and emit a large amount of green house gases. Especially in developing countries, such as China, India and Malaysia, this problem has intensified over the last 15 years. In China alone, 10 to 20 million tons of coal are believed to be lost in uncontrolled coal fires. The cooperation of developing countries and industrialized countries is needed to enforce internationally concerted approaches and political attention towards the problem. The Clean Development Mechanism (CDM) under the framework of the Kyoto Protocol may provide an international stage for financial investment needed to fight the disastrous situation. A Sino-German research project for coal fire exploration, monitoring and extinction applied several geophysical approaches in order to estimate the annual baseline especially of CO2 emissions from near subsurface coal fires. As a result of this project, we present verifiable methodologies that may be used in the CDM framework to estimate the amount of CO2 emissions from near subsurface coal fires. We developed three possibilities to approach the estimation based on (1) thermal energy release, (2) geological and geometrical determinations as well as (3) direct gas measurement. The studies involve the investigation of the physical property changes of the coal seam and bedrock during different burning stages of a underground coal fire. Various geophysical monitoring methods were applied from near surface to determine the coal volume, fire propagation, temperature anomalies, etc.

FIRE-PRAN

International Nuclear Information System (INIS)

Waterfall, K.W.

1991-01-01

Shell Internationale Petroleum Maatschappij B.V. (SIPM), is a service company in the Royal Dutch/Shell Group of Companies who provides services worldwide (outside of the USA) to Shell Operating Companies. It has defined and recommended for implementation by Shell Companies a policy on safety (Enhanced Safety Management policy) to manage the total safety aspects of all they do, including the design, engineering, installation and operation of their facilities worldwide. This policy affects all activities in such a way as to avoid harm to health of, or injury to employees and others as well as avoiding damage to property. This in turn reflects through specific policies and standards for investment strategy, engineering and operations of facilities. With average Group losses due to major fires and explosion (for each incident over Brit-pounds 100,000) between 1988 and 1990 being of the order of Brit-pounds 28 million, there is an obvious potential to effectively employ fire protection criteria in design. However, Shell need to ensure the cost-effective application of protective measures, but first and foremost it is essential not to jeopardize life or risk damage to the environment. FIRE-PRAN has the possibility to do this efficiently as it is A systematic team approach for identification of all potential fire and explosion hazards and consequences, and a means for developing optimal means of protection for all types of facilities. It should thus be considered as an auditing technique, but one that fits into the overall safe management of activities. This paper discusses the status of development of the FIRE-PRAN technique following its successful application over a number of years to a variety of equipment and installations

Wildland fire limits subsequent fire occurrence

Science.gov (United States)

Sean A. Parks; Carol Miller; Lisa M. Holsinger; Scott Baggett; Benjamin J. Bird

2016-01-01

Several aspects of wildland fire are moderated by site- and landscape-level vegetation changes caused by previous fire, thereby creating a dynamic where one fire exerts a regulatory control on subsequent fire. For example, wildland fire has been shown to regulate the size and severity of subsequent fire. However, wildland fire has the potential to influence...

Indonesian fire activity and smoke pollution in 2015 show persistent nonlinear sensitivity to El Niño-induced drought

NARCIS (Netherlands)

Field, Robert D.; Van Der Werf, Guido R.; Fanin, Thierry; Fetzer, Eric J.; Fuller, Ryan; Jethva, Hiren; Levy, Robert; Livesey, Nathaniel J.; Luo, Ming; Torres, Omar; Worden, Helen M.

2016-01-01

The 2015 fire season and related smoke pollution in Indonesia was more severe than the major 2006 episode,making it themost severe season observed by the NASA Earth Observing System satellites that go back to the early 2000s, namely active fire detections from the Terra and Aqua Moderate Resolution

Mitigating operating room fires: development of a carbon dioxide fire prevention device.

Science.gov (United States)

Culp, William C; Kimbrough, Bradly A; Luna, Sarah; Maguddayao, Aris J

2014-04-01

Operating room fires are sentinel events that present a real danger to surgical patients and occur at least as frequently as wrong-sided surgery. For fire to occur, the 3 points of the fire triad must be present: an oxidizer, an ignition source, and fuel source. The electrosurgical unit (ESU) pencil triggers most operating room fires. Carbon dioxide (CO2) is a gas that prevents ignition and suppresses fire by displacing oxygen. We hypothesize that a device can be created to reduce operating room fires by generating a cone of CO2 around the ESU pencil tip. One such device was created by fabricating a divergent nozzle and connecting it to a CO2 source. This device was then placed over the ESU pencil, allowing the tip to be encased in a cone of CO2 gas. The device was then tested in 21%, 50%, and 100% oxygen environments. The ESU was activated at 50 W cut mode while placing the ESU pencil tip on a laparotomy sponge resting on an aluminum test plate for up to 30 seconds or until the sponge ignited. High-speed videography was used to identify time of ignition. Each test was performed in each oxygen environment 5 times with the device activated (CO2 flow 8 L/min) and with the device deactivated (no CO2 flow-control). In addition, 3-dimensional spatial mapping of CO2 concentrations was performed with a CO2 sampling device. The median ± SD [range] ignition time of the control group in 21% oxygen was 2.9 s ± 0.44 [2.3-3.0], in 50% oxygen 0.58 s ± 0.12 [0.47-0.73], and in 100% oxygen 0.48 s ± 0.50 [0.03-1.27]. Fires were ignited with each control trial (15/15); no fires ignited when the device was used (0/15, P fire prevention device can be created by using a divergent nozzle design through which CO2 passes, creating a cone of fire suppressant. This device as demonstrated in a flammability model effectively reduced the risk of fire. CO2 3-dimensional spatial mapping suggests effective fire reduction at least 1 cm away from the tip of the ESU pencil at 8 L/min CO2 flow

Innexin gap junctions in nerve cells coordinate spontaneous contractile behavior in Hydra polyps

KAUST Repository

Takaku, Yasuharu

2014-01-07

Nerve cells and spontaneous coordinated behavior first appeared near the base of animal evolution in the common ancestor of cnidarians and bilaterians. Experiments on the cnidarian Hydra have demonstrated that nerve cells are essential for this behavior, although nerve cells in Hydra are organized in a diffuse network and do not form ganglia. Here we show that the gap junction protein innexin-2 is expressed in a small group of nerve cells in the lower body column of Hydra and that an anti-innexin-2 antibody binds to gap junctions in the same region. Treatment of live animals with innexin-2 antibody eliminates gap junction staining and reduces spontaneous body column contractions. We conclude that a small subset of nerve cells, connected by gap junctions and capable of synchronous firing, act as a pacemaker to coordinate the contraction of the body column in the absence of ganglia.

FIRE PROTECTION SYSTEMS AND TECHNOLOGIES

Directory of Open Access Journals (Sweden)

Aristov Denis Ivanovich

2016-03-01

Full Text Available The All-Russian Congress “Fire Stop Moscow” was de-voted to the analysis of the four segments of the industry of fire protection systems and technologies: the design of fire protec-tion systems, the latest developments and technologies of active and passive fire protection of buildings, the state and the devel-opment of the legal framework, the practice of fire protection of buildings and structures. The forum brought together the repre-sentatives of the industry of fire protection systems, scientists, leading experts, specialists in fire protection and representatives of construction companies from different regions of Russia. In parallel with the Congress Industrial Exhibition of fire protection systems, materials and technology was held, where manufacturers presented their products. The urgency of the “Fire Stop Moscow” Congress in 2015 organized by the Congress Bureau ODF Events lies primarily in the fact that it considered the full range of issues related to the fire protection of building and construction projects; studied the state of the regulatory framework for fire safety and efficiency of public services, research centers, private companies and busi-nesses in the area of fire safety. The main practical significance of the event which was widely covered in the media space, was the opportunity to share the views and information between management, science, and practice of business on implementing fire protection systems in the conditions of modern economic relations and market realities. : congress, fire protection, systems, technologies, fire protection systems, exhibition

Coal fires in Indonesia

Energy Technology Data Exchange (ETDEWEB)

Whitehouse, Alfred E.; Mulyana, Asep A.S. [Office of Surface Mining/Ministry of Energy and Mineral Resources Coal Fire Project, Ministry of Energy and Mineral Resources, Agency for Training and Education, Jl. Gatot Subroto, Kav. 49, Jakarta 12950 (Indonesia)

2004-07-12

Indonesia's fire and haze problem is increasingly being ascribed to large-scale forest conversion and land clearing activities making way for pulpwood, rubber and oil palm plantations. Fire is the cheapest tool available to small holders and plantation owners to reduce vegetation cover and prepare and fertilize extremely poor soils. Fires that escaped from agricultural burns have ravaged East Kalimantan forests on the island of Borneo during extreme drought periods in 1982-1983, 1987, 1991, 1994 and 1997-1998. Estimates based on satellite data and ground observations are that more than five million hectares were burned in East Kalimantan during the 1997/1998 dry season. Not only were the economic losses and ecological damage from these surface fires enormous, they ignited coal seams exposed at the ground surface along their outcrops.Coal fires now threaten Indonesia's shrinking ecological resources in Kutai National Park and Sungai Wain Nature Reserve. Sungai Wain has one of the last areas of unburned primary rainforest in the Balikpapan-Samarinda area with an extremely rich biodiversity. Although fires in 1997/1998 damaged nearly 50% of this Reserve and ignited 76 coal fires, it remains the most valuable water catchment area in the region and it has been used as a reintroduction site for the endangered orangutan. The Office of Surface Mining provided Indonesia with the capability to take quick action on coal fires that presented threats to public health and safety, infrastructure or the environment. The US Department of State's Southeast Asia Environmental Protection Initiative through the US Agency for International Development funded the project. Technical assistance and training transferred skills in coal fire management through the Ministry of Energy and Mineral Resource's Training Agency to the regional offices; giving the regions the long-term capability to manage coal fires. Funding was also included to extinguish coal fires as

Fire and Water combined: Understanding the Relevance of Working Life Studies through a Concept of Practical Activity

Directory of Open Access Journals (Sweden)

Keijo Räsänen

2015-11-01

Full Text Available When I presented the basic ideas of this paper at a conference, a Swedish colleague commented: ‘you manage to combine water and fire.’ I understood his kind comment to mean that he used water and fire as metaphors for practice and theory. The comment puzzled me for a while. Water and fire obviously destroy each other, or at least radically transform each other. Then I realized that humans have actually managed to combine water and fire in several ways. One solution is the kettle. It makes possible to use fire in a controlled way for the human purpose of boiling water. Thus, this paper can be taken as an attempt at offering a kettle-like vehicle for bringing together practicetheoretical concepts and vocational practice. My kettle is a concept of practical activity. I am trying to boil up an answer to the following question: in what senses a study of work can be practically relevant to those who are doing the work being studied?

Seasonal changes in the human alteration of fire regimes beyond the climate forcing

Science.gov (United States)

Fréjaville, Thibaut; Curt, Thomas

2017-03-01

Human activities have altered fire regimes for millennia by suppressing or enhancing natural fire activity. However, whether these anthropogenic pressures on fire activity have exceeded and will surpass climate forcing still remains uncertain. We tested if, how and the extent to which seasonal fire activity in southern France has recently (1976-2009) deviated from climate-expected trends. The latter were simulated using an ensemble of detrended fire-climate models. We found both seasonal and regional contrasts in climatic effects through a mixture of drought-driven and fuel-limited fire regimes. Dry contemporary conditions chiefly drove fire frequency and burned area, although higher fire activity was related to wetter conditions in the last three years. Surprisingly, the relative importance of preceding wet conditions was higher in winter than in summer, illustrating the strong potential dependency of regional fire-climate relationships on the human use and control of fires. In the Mediterranean mountains, warm winters and springs favour extensive fires in the following dry summer. These results highlight that increasing dryness with climate change could have antagonistic effects on fire regime by leading to larger fires in summer (moisture-limited), but lower fire activity in winter (fuel-limited fire regime). Furthermore, fire trends have significantly diverged from climatic expectations, with a strong negative alteration in fire activity in the Mediterranean lowlands and the summer burned area in the mountains. In contrast, alteration of winter fire frequency in the Mediterranean and Temperate mountains has shifted from positive to negative (or null) trends during the mid-1990s, a period when fire suppression policy underwent major revisions. Our findings demonstrate that changes in land-use and fire suppression policy have probably exceeded the strength of climate change effects on changing fire regime in southern Europe, making regional predictions of future

Predicting wildfire ignitions, escapes, and large fire activity using Predictive Service’s 7-Day Fire Potential Outlook in the western USA

Science.gov (United States)

Karin L. Riley; Crystal Stonesifer; Haiganoush Preisler; Dave Calkin

2014-01-01

Can fire potential forecasts assist with pre-positioning of fire suppression resources, which could result in a cost savings to the United States government? Here, we present a preliminary assessment of the 7-Day Fire Potential Outlook forecasts made by the Predictive Services program. We utilized historical fire occurrence data and archived forecasts to assess how...

Utilizing Multi-Sensor Fire Detections to Map Fires in the United States

Science.gov (United States)

Howard, S. M.; Picotte, J. J.; Coan, M. J.

2014-11-01

In 2006, the Monitoring Trends in Burn Severity (MTBS) project began a cooperative effort between the US Forest Service (USFS) and the U.S.Geological Survey (USGS) to map and assess burn severity all large fires that have occurred in the United States since 1984. Using Landsat imagery, MTBS is mandated to map wildfire and prescribed fire that meet specific size criteria: greater than 1000 acres in the west and 500 acres in the east, regardless of ownership. Relying mostly on federal and state fire occurrence records, over 15,300 individual fires have been mapped. While mapping recorded fires, an additional 2,700 "unknown" or undocumented fires were discovered and assessed. It has become apparent that there are perhaps thousands of undocumented fires in the US that are yet to be mapped. Fire occurrence records alone are inadequate if MTBS is to provide a comprehensive accounting of fire across the US. Additionally, the sheer number of fires to assess has overwhelmed current manual procedures. To address these problems, the National Aeronautics and Space Administration (NASA) Applied Sciences Program is helping to fund the efforts of the USGS and its MTBS partners (USFS, National Park Service) to develop, and implement a system to automatically identify fires using satellite data. In near real time, USGS will combine active fire satellite detections from MODIS, AVHRR and GOES satellites with Landsat acquisitions. Newly acquired Landsat imagery will be routinely scanned to identify freshly burned area pixels, derive an initial perimeter and tag the burned area with the satellite date and time of detection. Landsat imagery from the early archive will be scanned to identify undocumented fires. Additional automated fire assessment processes will be developed. The USGS will develop these processes using open source software packages in order to provide freely available tools to local land managers providing them with the capability to assess fires at the local level.

Summary of HEDL sodium fire tests

International Nuclear Information System (INIS)

Hillard, R.K.

1978-10-01

The sodium fire test program and related studies at the Hanford Engineering Development Laboratory (HEDL) are described. The program is analytical and experimental in scope, with computer code development and experimental verification. Tests have ranged in size from gram quantity laboratory tests to 1600-kg sodium spills. The experimental work is performed in two facilities: the Large Sodium Fire Facility (LSFF) and the Containment Systems Test Facility (CSTF). Sodium fire extinguishment tests which verified the Fast Flux Test Facility (FFTF) secondary sodium fire protection system are described and related informaion on sodium burning rates and smoke release rates are correlated. The burning rates are compared to theoretical predictions based on heat and mass transfer analogy, with good agreement. Comparisons with the SOFIRE-II code are also made. Sodium combustion aerosol properties are defined as to chemical and physical nature, settling in closed vessels and effect of added water vapor. The HAA-3B aerosol behavior computer code is compared to tests in the 850-m 3 CSTF containment vessel. Sodium spray tests in the CSTF are compared with the SPRAY computer code. An air cleaning program is described, which has the objective of removing high mass concentration sodium combustion aerosols from vented cells and containment buildings. The aerosol mass holding capacity of commercial filters was measured and an aqueous scrubber system is described. The effects of sodium spills on cell structures were investigated, including water release from heated concrete, the reaction of sodium with concrete, the formation and spontaneous recombination of hydrogen, and the ability of steel cell liners to withstand large spills of high temperature sodium without leaking

Active caspase-3 and ultrastructural evidence of apoptosis in spontaneous and induced cell death in bovine in vitro produced pre-implantation embryos

DEFF Research Database (Denmark)

Gjørret, Jakob O.; Fabian, Dusan; Avery, Birthe

2007-01-01

In this study we investigated chronological onset and involvement of active caspase-3, apoptotic nuclear morphology, and TUNEL-labeling, as well as ultrastructural evidence of apoptosis, in both spontaneous and induced cell death during pre-implantation development of bovine in vitro produced...... microscopy in both treated and untreated blastocysts. Activation of caspase-3 is likely involved in both spontaneous and induced apoptosis in bovine pre-implantation embryos, and immunohistochemical staining of active caspase-3 may be used in combination with other markers to identify apoptosis in pre...... embryos. Pre-implantation embryos (2-cell to Day 8 blastocysts) were cultured with either no supplementation (untreated) or with 10 µM staurosporine for 24 hr (treated). Embryos were subjected to immunohistochemical staining of active caspase-3, TUNEL-reaction for detection of DNA degradation and DAPI...

Soil microbiological properties and enzymatic activities of long-term post-fire recovery in dry and semiarid Aleppo pine (Pinus halepensis M.) forest stands

Science.gov (United States)

Hedo, J.; Lucas-Borja, M. E.; Wic, C.; Andrés-Abellán, M.; de Las Heras, J.

2015-02-01

Wildfires affecting forest ecosystems and post-fire silvicultural treatments may cause considerable changes in soil properties. The capacity of different microbial groups to recolonise soil after disturbances is crucial for proper soil functioning. The aim of this work was to investigate some microbial soil properties and enzyme activities in semiarid and dry Aleppo pine (Pinus halepensis M.) forest stands. Different plots affected by a wildfire event 17 years ago without or with post-fire silvicultural treatments 5 years after the fire event were selected. A mature Aleppo pine stand, unaffected by wildfire and not thinned was used as a control. Physicochemical soil properties (soil texture, pH, carbonates, organic matter, electrical conductivity, total N and P), soil enzymes (urease, phosphatase, β-glucosidase and dehydrogenase activities), soil respiration and soil microbial biomass carbon were analysed in the selected forests areas and plots. The main finding was that long time after this fire event produces no differences in the microbiological soil properties and enzyme activities of soil after comparing burned and thinned, burned and not thinned, and mature plots. Moreover, significant site variation was generally seen in soil enzyme activities and microbiological parameters. We conclude that total vegetation recovery normalises post-fire soil microbial parameters, and that wildfire and post-fire silvicultural treatments are not significant factors affecting soil properties after 17 years.

Algorithm and assessment work of active fire detection based on FengYun-3C/VIRR

Science.gov (United States)

Lin, Z.; Chen, F.

2017-12-01

The wildfire is one of the most destructive and uncontrollable disasters and causes huge environmental, ecological, social effects. To better serve scientific research and practical fire management, an algorithm and corresponding validation work of active fire detection based on FengYun-3C/VIRR data, which is an optical sensor onboard the Chinese polar-orbiting meteorological sun-synchronous satellite, is hereby introduced. While the main structure heritages the `contextual algorithm', some new concepts including `infrared channel slope' are introduced for better adaptions to different situations. The validation work contains three parts: 1) comparing with the current FengYun-3C fire product GFR; 2) comparing with MODIS fire products; 3) comparing with Landsat series data. Study areas are selected from different places all over the world from 2014 to 2016. The results showed great improvement on GFR files on accuracy of both positioning and detection rate. In most study areas, the results match well with MODIS products and Landsat series data (with over 85% match degree) despite the differences in imaging time. However, detection rates and match degrees in Africa and South-east Asia are not satisfied (around 70%), where the occurrences of numerous small fire events and corresponding smokes may strongly affect the results of the algorithm. This is our future research direction and one of the main improvements requires achieving.

A hydroclimatic model of global fire patterns

Science.gov (United States)

Boer, Matthias

2015-04-01

Satellite-based earth observation is providing an increasingly accurate picture of global fire patterns. The highest fire activity is observed in seasonally dry (sub-)tropical environments of South America, Africa and Australia, but fires occur with varying frequency, intensity and seasonality in almost all biomes on Earth. The particular combination of these fire characteristics, or fire regime, is known to emerge from the combined influences of climate, vegetation, terrain and land use, but has so far proven difficult to reproduce by global models. Uncertainty about the biophysical drivers and constraints that underlie current global fire patterns is propagated in model predictions of how ecosystems, fire regimes and biogeochemical cycles may respond to projected future climates. Here, I present a hydroclimatic model of global fire patterns that predicts the mean annual burned area fraction (F) of 0.25° x 0.25° grid cells as a function of the climatic water balance. Following Bradstock's four-switch model, long-term fire activity levels were assumed to be controlled by fuel productivity rates and the likelihood that the extant fuel is dry enough to burn. The frequency of ignitions and favourable fire weather were assumed to be non-limiting at long time scales. Fundamentally, fuel productivity and fuel dryness are a function of the local water and energy budgets available for the production and desiccation of plant biomass. The climatic water balance summarizes the simultaneous availability of biologically usable energy and water at a site, and may therefore be expected to explain a significant proportion of global variation in F. To capture the effect of the climatic water balance on fire activity I focused on the upper quantiles of F, i.e. the maximum level of fire activity for a given climatic water balance. Analysing GFED4 data for annual burned area together with gridded climate data, I found that nearly 80% of the global variation in the 0.99 quantile of F

Trends and Variability of Global Fire Emissions Due To Historical Anthropogenic Activities

Science.gov (United States)

Ward, Daniel S.; Shevliakova, Elena; Malyshev, Sergey; Rabin, Sam

2018-01-01

Globally, fires are a major source of carbon from the terrestrial biosphere to the atmosphere, occurring on a seasonal cycle and with substantial interannual variability. To understand past trends and variability in sources and sinks of terrestrial carbon, we need quantitative estimates of global fire distributions. Here we introduce an updated version of the Fire Including Natural and Agricultural Lands model, version 2 (FINAL.2), modified to include multiday burning and enhanced fire spread rate in forest crowns. We demonstrate that the improved model reproduces the interannual variability and spatial distribution of fire emissions reported in present-day remotely sensed inventories. We use FINAL.2 to simulate historical (post-1700) fires and attribute past fire trends and variability to individual drivers: land use and land cover change, population growth, and lightning variability. Global fire emissions of carbon increase by about 10% between 1700 and 1900, reaching a maximum of 3.4 Pg C yr-1 in the 1910s, followed by a decrease to about 5% below year 1700 levels by 2010. The decrease in emissions from the 1910s to the present day is driven mainly by land use change, with a smaller contribution from increased fire suppression due to increased human population and is largest in Sub-Saharan Africa and South Asia. Interannual variability of global fire emissions is similar in the present day as in the early historical period, but present-day wildfires would be more variable in the absence of land use change.

Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart.

Directory of Open Access Journals (Sweden)

Stéphanie C Choisy

Full Text Available The atrioventricular node (AVN is a key component of the cardiac pacemaker-conduction system. Although it is known that receptors for the peptide hormone endothelin-1 (ET-1 are expressed in the AVN, there is very little information available on the modulatory effects of ET-1 on AVN electrophysiology. This study characterises for the first time acute modulatory effects of ET-1 on AVN cellular electrophysiology.Electrophysiological experiments were conducted in which recordings were made from rabbit isolated AVN cells at 35-37°C using the whole-cell patch clamp recording technique.Application of ET-1 (10 nM to spontaneously active AVN cells led rapidly (within ~13 s to membrane potential hyperpolarisation and cessation of spontaneous action potentials (APs. This effect was prevented by pre-application of the ET(A receptor inhibitor BQ-123 (1 µM and was not mimicked by the ET(B receptor agonist IRL-1620 (300 nM. In whole-cell voltage-clamp experiments, ET-1 partially inhibited L-type calcium current (I(Ca,L and rapid delayed rectifier K(+ current (I(Kr, whilst it transiently activated the hyperpolarisation-activated current (I(f at voltages negative to the pacemaking range, and activated an inwardly rectifying current that was inhibited by both tertiapin-Q (300 nM and Ba(2+ ions (2 mM; each of these effects was sensitive to ET(A receptor inhibition. In cells exposed to tertiapin-Q, ET-1 application did not produce membrane potential hyperpolarisation or immediate cessation of spontaneous activity; instead, there was a progressive decline in AP amplitude and depolarisation of maximum diastolic potential.Acutely applied ET-1 exerts a direct modulatory effect on AVN cell electrophysiology. The dominant effect of ET-1 in this study was activation of a tertiapin-Q sensitive inwardly rectifying K(+ current via ET(A receptors, which led rapidly to cell quiescence.

Incorporating anthropogenic influences into fire probability models: Effects of development and climate change on fire activity in California

Science.gov (United States)

Mann, M.; Moritz, M.; Batllori, E.; Waller, E.; Krawchuk, M.; Berck, P.

2014-12-01

The costly interactions between humans and natural fire regimes throughout California demonstrate the need to understand the uncertainties surrounding wildfire, especially in the face of a changing climate and expanding human communities. Although a number of statistical and process-based wildfire models exist for California, there is enormous uncertainty about the location and number of future fires. Models estimate an increase in fire occurrence between nine and fifty-three percent by the end of the century. Our goal is to assess the role of uncertainty in climate and anthropogenic influences on the state's fire regime from 2000-2050. We develop an empirical model that integrates novel information about the distribution and characteristics of future plant communities without assuming a particular distribution, and improve on previous efforts by integrating dynamic estimates of population density at each forecast time step. Historically, we find that anthropogenic influences account for up to fifty percent of the total fire count, and that further housing development will incite or suppress additional fires according to their intensity. We also find that the total area burned is likely to increase but at a slower than historical rate. Previous findings of substantially increased numbers of fires may be tied to the assumption of static fuel loadings, and the use of proxy variables not relevant to plant community distributions. We also find considerable agreement between GFDL and PCM model A2 runs, with decreasing fire counts expected only in areas of coastal influence below San Francisco and above Los Angeles. Due to potential shifts in rainfall patterns, substantial uncertainty remains for the semiarid deserts of the inland south. The broad shifts of wildfire between California's climatic regions forecast in this study point to dramatic shifts in the pressures plant and human communities will face by midcentury. The information provided by this study reduces the

Activation of KCNQ Channels Suppresses Spontaneous Activity in Dorsal Root Ganglion Neurons and Reduces Chronic Pain after Spinal Cord Injury.

Science.gov (United States)

Wu, Zizhen; Li, Lin; Xie, Fuhua; Du, Junhui; Zuo, Yan; Frost, Jeffrey A; Carlton, Susan M; Walters, Edgar T; Yang, Qing

2017-03-15

A majority of people who have sustained spinal cord injury (SCI) experience chronic pain after injury, and this pain is highly resistant to available treatments. Contusive SCI in rats at T10 results in hyperexcitability of primary sensory neurons, which contributes to chronic pain. KCNQ channels are widely expressed in nociceptive dorsal root ganglion (DRG) neurons, are important for controlling their excitability, and their activation has proven effective in reducing pain in peripheral nerve injury and inflammation models. The possibility that activators of KCNQ channels could be useful for treating SCI-induced chronic pain is strongly supported by the following findings. First, SCI, unlike peripheral nerve injury, failed to decrease the functional or biochemical expression of KCNQ channels in DRG as revealed by electrophysiology, real-time quantitative polymerase chain reaction, and Western blot; therefore, these channels remain available for pharmacological targeting of SCI pain. Second, treatment with retigabine, a specific KCNQ channel opener, profoundly decreased spontaneous activity in primary sensory neurons of SCI animals both in vitro and in vivo without changing the peripheral mechanical threshold. Third, retigabine reversed SCI-induced reflex hypersensitivity, adding to our previous demonstration that retigabine supports the conditioning of place preference after SCI (an operant measure of spontaneous pain). In contrast to SCI animals, naïve animals showed no effects of retigabine on reflex sensitivity or conditioned place preference by pairing with retigabine, indicating that a dose that blocks chronic pain-related behavior has no effect on normal pain sensitivity or motivational state. These results encourage the further exploration of U.S. Food and Drug Administration-approved KCNQ activators for treating SCI pain, as well as efforts to develop a new generation of KCNQ activators that lack central side effects.

Modeling the effects of fire severity and climate warming on active layer thickness and soil carbon storage of black spruce forests across the landscape in interior Alaska

International Nuclear Information System (INIS)

Genet, H; Euskirchen, E S; McGuire, A D; Barrett, K; Breen, A; Bennett, A; Rupp, T S; Johnstone, J F; Kasischke, E S; Melvin, A M; Mack, M C; Schuur, A E G; Turetsky, M R; Yuan, F

2013-01-01

There is a substantial amount of carbon stored in the permafrost soils of boreal forest ecosystems, where it is currently protected from decomposition. The surface organic horizons insulate the deeper soil from variations in atmospheric temperature. The removal of these insulating horizons through consumption by fire increases the vulnerability of permafrost to thaw, and the carbon stored in permafrost to decomposition. In this study we ask how warming and fire regime may influence spatial and temporal changes in active layer and carbon dynamics across a boreal forest landscape in interior Alaska. To address this question, we (1) developed and tested a predictive model of the effect of fire severity on soil organic horizons that depends on landscape-level conditions and (2) used this model to evaluate the long-term consequences of warming and changes in fire regime on active layer and soil carbon dynamics of black spruce forests across interior Alaska. The predictive model of fire severity, designed from the analysis of field observations, reproduces the effect of local topography (landform category, the slope angle and aspect and flow accumulation), weather conditions (drought index, soil moisture) and fire characteristics (day of year and size of the fire) on the reduction of the organic layer caused by fire. The integration of the fire severity model into an ecosystem process-based model allowed us to document the relative importance and interactions among local topography, fire regime and climate warming on active layer and soil carbon dynamics. Lowlands were more resistant to severe fires and climate warming, showing smaller increases in active layer thickness and soil carbon loss compared to drier flat uplands and slopes. In simulations that included the effects of both warming and fire at the regional scale, fire was primarily responsible for a reduction in organic layer thickness of 0.06 m on average by 2100 that led to an increase in active layer thickness

Fire-safety engineering and performance-based codes

DEFF Research Database (Denmark)

Sørensen, Lars Schiøtt

project administrators, etc. The book deals with the following topics: • Historical presentation on the subject of fire • Legislation and building project administration • European fire standardization • Passive and active fire protection • Performance-based Codes • Fire-safety Engineering • Fundamental......Fire-safety Engineering is written as a textbook for Engineering students at universities and other institutions of higher education that teach in the area of fire. The book can also be used as a work of reference for consulting engineers, Building product manufacturers, contractors, building...... thermodynamics • Heat exchange during the fire process • Skin burns • Burning rate, energy release rate and design fires • Proposal to Risk-based design fires • Proposal to a Fire scale • Material ignition and flame spread • Fire dynamics in buildings • Combustion products and toxic gases • Smoke inhalation...

Advanced Fire Information System - A real time fire information system for Africa

Science.gov (United States)

Frost, P. E.; Roy, D. P.

2012-12-01

The Council for Scientific and Industrial Research (CSIR) lead by the Meraka Institute and supported by the South African National Space Agency (SANSA) developed the Advanced Fire Information System (AFIS) to provide near real time fire information to a variety of operational and science fire users including disaster managers, fire fighters, farmers and forest managers located across Southern and Eastern Africa. The AFIS combines satellite data with ground based observations and statistics and distributes the information via mobile phone technology. The system was launched in 2004, and Eskom (South Africa' and Africa's largest power utility) quickly became the biggest user and today more than 300 Eskom line managers and support staff receive cell phone and email fire alert messages whenever a wildfire is within 2km of any of the 28 000km of Eskom electricity transmission lines. The AFIS uses Earth observation satellites from NASA and Europe to detect possible actively burning fires and their fire radiative power (FRP). The polar orbiting MODIS Terra and Aqua satellites provide data at around 10am, 15pm, 22am and 3am daily, while the European Geostationary MSG satellite provides 15 minute updates at lower spatial resolution. The AFIS processing system ingests the raw satellite data and within minutes of the satellite overpass generates fire location and FRP based fire intensity information. The AFIS and new functionality are presented including an incident report and permiting system that can be used to differentiate between prescribed burns and uncontrolled wild fires, and the provision of other information including 5-day fire danger forecasts, vegetation curing information and historical burned area maps. A new AFIS mobile application for IOS and Android devices as well as a fire reporting tool are showcased that enable both the dissemination and alerting of fire information and enable user upload of geo tagged photographs and on the fly creation of fire reports

National Fire Incident Reporting System (NFIRS)

Data.gov (United States)

Department of Homeland Security — The National Fire Incident Reporting System (NFIRS) is a reporting standard that fire departments use to uniformly report on the full range of their activities, from...

Weather and human impacts on forest fires: 100 years of fire history in two climatic regions of Switzerland

NARCIS (Netherlands)

Zumbrunnen, T.; Pezzatti, B.; Menendez, P.; Bugmann, H.; Brgi, M.; Conedera, M.

2011-01-01

Understanding the factors driving past fire regimes is crucial in the context of global change as a basis for predicting future changes. In this study, we aimed to identify the impact of climate and human activities on fire occurrence in the most fire-prone regions of Switzerland. We considered

One thousand years of fires: Integrating proxy and model data

Directory of Open Access Journals (Sweden)

Natalie Marie Kehrwald

2016-04-01

Full Text Available The current fires raging across Indonesia are emitting more carbon than the annual fossil fuel emissions of Germany or Japan, and the fires are still consuming vast tracts of rainforest and peatlands. The National Interagency Fire Center (www.nifc.gov notes that 2015 is one worst fire years on record in the U.S., where more than 9 million acres burned -- equivalent to the combined size of Massachusetts and New Jersey. The U.S. and Indonesian fires have already displaced tens of thousands of people, and their impacts on ecosystems are still unclear. In the case of Indonesia, the burning peat is destroying much of the existing soil, with unknown implications for the type of vegetation regrowth. Such large fires result from a combination of fire management practices, increasing anthropogenic land use, and a changing climate. The expected increase in fire activity in the upcoming decades has led to a surge in research trying to understand their causes, the factors that may have influenced similar times of fire activity in the past, and the implications of such fire activity in the future. Multiple types of complementary data provide information on the impacts of current fires and the extent of past fires. The wide array of data encompasses different spatial and temporal resolutions (Figure 1 and includes fire proxy information such as charcoal and tree ring fire scars, observational records, satellite products, modern emissions data, fire models within global land cover and vegetation models, and sociodemographic data for modeling past human land use and ignition frequency. Any single data type is more powerful when combined with another source of information. Merging model and proxy data enables analyses of how fire activity modifies vegetation distribution, air and water quality, and proximity to cities; these analyses in turn support land management decisions relating to conservation and development.

Cavity enhanced rephased amplified spontaneous emission

International Nuclear Information System (INIS)

A Williamson, Lewis; J Longdell, Jevon

2014-01-01

Amplified spontaneous emission is usually treated as an incoherent noise process. Recent theoretical and experimental work using rephasing optical pulses has shown that rephased amplified spontaneous emission (RASE) is a potential source of wide bandwidth time-delayed entanglement. Due to poor echo efficiency the plain RASE protocol does not in theory achieve perfect entanglement. Experiments done to date show a very small amount of entanglement at best. Here we show that RASE can, in principle, produce perfect multimode time-delayed two mode squeezing when the active medium is placed inside a Q-switched cavity. (paper)

Global Burned Area and Biomass Burning Emissions from Small Fires

Science.gov (United States)

Randerson, J. T.; Chen, Y.; vanderWerf, G. R.; Rogers, B. M.; Morton, D. C.

2012-01-01

In several biomes, including croplands, wooded savannas, and tropical forests, many small fires occur each year that are well below the detection limit of the current generation of global burned area products derived from moderate resolution surface reflectance imagery. Although these fires often generate thermal anomalies that can be detected by satellites, their contributions to burned area and carbon fluxes have not been systematically quantified across different regions and continents. Here we developed a preliminary method for combining 1-km thermal anomalies (active fires) and 500 m burned area observations from the Moderate Resolution Imaging Spectroradiometer (MODIS) to estimate the influence of these fires. In our approach, we calculated the number of active fires inside and outside of 500 m burn scars derived from reflectance data. We estimated small fire burned area by computing the difference normalized burn ratio (dNBR) for these two sets of active fires and then combining these observations with other information. In a final step, we used the Global Fire Emissions Database version 3 (GFED3) biogeochemical model to estimate the impact of these fires on biomass burning emissions. We found that the spatial distribution of active fires and 500 m burned areas were in close agreement in ecosystems that experience large fires, including savannas across southern Africa and Australia and boreal forests in North America and Eurasia. In other areas, however, we observed many active fires outside of burned area perimeters. Fire radiative power was lower for this class of active fires. Small fires substantially increased burned area in several continental-scale regions, including Equatorial Asia (157%), Central America (143%), and Southeast Asia (90%) during 2001-2010. Globally, accounting for small fires increased total burned area by approximately by 35%, from 345 Mha/yr to 464 Mha/yr. A formal quantification of uncertainties was not possible, but sensitivity

Underground Coal-Fires in Xinjiang, China: A Continued Effort in Applying Geophysics to Solve a Local Problem and to Mitigate a Global Hazard

Science.gov (United States)

Wuttke, M. W.; Halisch, M.; Tanner, D. C.; Cai, Z. Y.; Zeng, Q.; Wang, C.

2012-04-01

Spontaneous uncontrolled coal seam fires are a well known phenomenon that causes severe environmental problems and severe impact on natural coal reserves. Coal fires are a worldwide phenomenon, but in particular in Xinjiang, that covers 17.3 % of Chinas area and hosts approx 42 % of its coal resources. In Xinjiang since more than 50 years a rigorous strategy for fire fighting on local and regional scale is persued. The Xinjiang Coalfield Fire Fighting Bureau (FFB) has developed technologies and methods to deal with any known fire. Many fires have been extinguished already, but the problem is still there if not even growing. This problem is not only a problem for China due to the loss of valuable energy resources, but it is also a worldwide threat because of the generation of substantial amounts of greenhouse gases. Through the FFB, China is struggling to overcome this, but the activities could be much enhanced by the continuation of the already successful conjoint operations. The last ten years have seen two successful cooperative projects between China and Germany on the field of coal-fire fighting, namely the German Technical Cooperation Project on Coal Fire in Xinjiang and the Sino-German Coal Fire Research Initiative funded by the corresponding ministeries of both countries. A persistent task in the fire fighting is the identification and supervision of areas with higher risks for the ignition of coal fires, the exploration of already ignited fire zones to extinguish the fires and the monitoring of extinguished fires to detect as early as possible process that may foster re-ignition. This can be achieved by modeling both the structures and the processes that are involved. This has also been a promising part of the past cooperation projects, yet to be transformed into a standard application of fire fighting procedures. In this contribution we describe the plans for a new conjoint project between China and Germany where on the basis of field investigations and

Fire activity as a function of fire–weather seasonal severity and antecedent climate across spatial scales in southern Europe and Pacific western USA

Science.gov (United States)

Urbieta, Itziar R.; Zavala, Gonzalo; Bedia, Joaquin; Gutierrez, Jose M.; San Miguel-Ayanz, Jesus; Camia, Andrea; Keeley, Jon E.; Moreno, Jose M.

2015-01-01

Climate has a strong influence on fire activity, varying across time and space. We analyzed the relationships between fire–weather conditions during the main fire season and antecedent water-balance conditions and fires in two Mediterranean-type regions with contrasted management histories: five southern countries of the European Union (EUMED)(all fires); the Pacific western coast of the USA (California and Oregon, PWUSA)(national forest fires). Total number of fires (≥1 ha), number of large fires (≥100 ha) and area burned were related to mean seasonal fire weather index (FWI), number of days over the 90th percentile of the FWI, and to the standardized precipitation-evapotranspiration index (SPEI) from the preceding 3 (spring) or 8 (autumn through spring) months. Calculations were made at three spatial aggregations in each area, and models related first-difference (year-to-year change) of fires and FWI/climate variables to minimize autocorrelation. An increase in mean seasonal FWI resulted in increases in the three fire variables across spatial scales in both regions. SPEI contributed little to explain fires, with few exceptions. Negative water-balance (dry) conditions from autumn through spring (SPEI8) were generally more important than positive conditions (moist) in spring (SPEI3), both of which contributed positively to fires. The R2 of the models generally improved with increasing area of aggregation. For total number of fires and area burned, the R2 of the models tended to decrease with increasing mean seasonal FWI. Thus, fires were more susceptible to change with climate variability in areas with less amenable conditions for fires (lower FWI) than in areas with higher mean FWI values. The relationships were similar in both regions, albeit weaker in PWUSA, probably due to the wider latitudinal gradient covered in PWUSA than in EUMED. The large variance explained by some of the models indicates that large-scale seasonal forecast could help anticipating

Evidence of Human Health Impacts from Uncontrolled Coal Fires in Jharia, India

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Dhar, U.; Balogun, A. H.; Finkelman, R.; Chakraborty, S.; Olanipekun, O.; Shaikh, W. A.

2017-12-01

Uncontrolled coal fires and burning coal waste piles have been reported from dozens of countries. These fires can be caused by spontaneous combustion, sparks from machinery, lightning strikes, grass or forest fires, or intentionally. Both underground and surface coal fires mobilize potentially toxic elements such as sulfur, arsenic, selenium, fluorine, lead, and mercury as well as dangerous organic compounds such as benzene, toluene, xylene, ethylbenzene and deadly gases such as CO2 and CO. Despite the serious health problems that can be caused by uncontrolled coal fires it is rather surprising that there has been so little research and documentation of their health impacts. Underground coal fires in the Jharia region of India where more than a million people reside, have been burning for 100 years. Numerous villages exist above the underground fires exposing the residents daily to dangerous emissions. Local residents near the fire affected areas do their daily chores without concern about the intensity of nearby fires. During winter children enjoy the heat of the coal fires oblivious to the potentially harmful emissions. To determine if these uncontrolled coal fires have caused health problems we developed a brief questionnaire on general health indices and administered it to residents of the Jharia region. Sixty responses were obtained from residents of two villages, one proximal to the coal fires and one about 5 miles away from the fires. The responses were statistically analyzed using SAS 9.4. It was observed that at a significance level of 5%, villagers who lived more than 5 miles away from the fires had a 98.3% decreased odds of having undesirable health outcomes. This brief survey indicates the risk posed by underground coal fires and how it contributes to the undesirable health impacts. What remains is to determine the specific health issues, what components of the emissions cause the health problems, and what can be done to minimize these problems

Spontaneous and evoked cerebral activity modifications on whole-body γ irradiated adult rabbit

International Nuclear Information System (INIS)

Court, L.; Dufour, R.; Bassant, M.H.; Fatome, M.

1976-01-01

Whole-body γ-exposure from 150 to 850 rads (dose-rate: 14 rads.min -1 ) delivered to adult rabbits chronically implanted with electrodes resulted in prompt and delayed changes of behavior, arousal and spontaneous and evoked electrical activities. Electrophysiological techniques of polygraphic recording and signal processing showed that the alterations were related to the absorbed dose. The threshold dose accompanied with transient changes of arousal should be in the range of 50-100 rads; below this range, to the exclusion of some possible behavior changes, exposure should act as a stimulation that would become nociceptive at higher doses only [fr

Idaho National Engineering and Environmental Laboratory Wildland Fire Management Environmental Assessment - April 2003

Energy Technology Data Exchange (ETDEWEB)

Irving, J.S.

2003-04-30

DOE prepared an environmental assessment (EA)for wildland fire management activities on the Idaho National Engineering and Environmental Laboratory (INEEL) (DOE/EA-1372). The EA was developed to evaluate wildland fire management options for pre-fire, fire suppression, and post fire activities. Those activities have an important role in minimizing the conversion of the native sagebrush steppe ecosystem found on the INEEL to non-native weeds. Four alternative management approaches were analyzed: Alternative 1 - maximum fire protection; Alternative 2 - balanced fire protection; Alternative 2 - balanced fire protection; Alternative 3 - protect infrastructure and personnel; and Alternative 4 - no action/traditional fire protection.

Mid-21st-century climate changes increase predicted fire occurrence and fire season length, Northern Rocky Mountains, United States

Science.gov (United States)

Riley, Karin L.; Loehman, Rachel A.

2016-01-01

Climate changes are expected to increase fire frequency, fire season length, and cumulative area burned in the western United States. We focus on the potential impact of mid-21st-century climate changes on annual burn probability, fire season length, and large fire characteristics including number and size for a study area in the Northern Rocky Mountains. Although large fires are rare they account for most of the area burned in western North America, burn under extreme weather conditions, and exhibit behaviors that preclude methods of direct control. Allocation of resources, development of management plans, and assessment of fire effects on ecosystems all require an understanding of when and where fires are likely to burn, particularly under altered climate regimes that may increase large fire occurrence. We used the large fire simulation model FSim to model ignition, growth, and containment of wildfires under two climate scenarios: contemporary (based on instrumental weather) and mid-century (based on an ensemble average of global climate models driven by the A1B SRES emissions scenario). Modeled changes in fire patterns include increased annual burn probability, particularly in areas of the study region with relatively short contemporary fire return intervals; increased individual fire size and annual area burned; and fewer years without large fires. High fire danger days, represented by threshold values of Energy Release Component (ERC), are projected to increase in number, especially in spring and fall, lengthening the climatic fire season. For fire managers, ERC is an indicator of fire intensity potential and fire economics, with higher ERC thresholds often associated with larger, more expensive fires. Longer periods of elevated ERC may significantly increase the cost and complexity of fire management activities, requiring new strategies to maintain desired ecological conditions and limit fire risk. Increased fire activity (within the historical range of

Early spontaneous intermittent myocardial reperfusion during acute myocardial infarction is associated with augmented thrombogenic activity and less myocardial damage

NARCIS (Netherlands)

Haider, A.W.; Andreotti, F.; Hackett, D.R.; Tousoulis, D.; Kluft, C.; Maseri, A.; Davies, G.J.

1995-01-01

Objectives. This study investigated the influence of early spontaneous intermittent reperfusion on the extent of myocardial damage and its relation to endogenous hemostatic activity, Background. In the early phase of acute myocardial infarction coronary occlusion is often intermittent, even before

Fire-extinguishing organic electrolytes for safe batteries

Science.gov (United States)

Wang, Jianhui; Yamada, Yuki; Sodeyama, Keitaro; Watanabe, Eriko; Takada, Koji; Tateyama, Yoshitaka; Yamada, Atsuo

2018-01-01

Severe safety concerns are impeding the large-scale employment of lithium/sodium batteries. Conventional electrolytes are highly flammable and volatile, which may cause catastrophic fires or explosions. Efforts to introduce flame-retardant solvents into the electrolytes have generally resulted in compromised battery performance because those solvents do not suitably passivate carbonaceous anodes. Here we report a salt-concentrated electrolyte design to resolve this dilemma via the spontaneous formation of a robust inorganic passivation film on the anode. We demonstrate that a concentrated electrolyte using a salt and a popular flame-retardant solvent (trimethyl phosphate), without any additives or soft binders, allows stable charge-discharge cycling of both hard-carbon and graphite anodes for more than 1,000 cycles (over one year) with negligible degradation; this performance is comparable or superior to that of conventional flammable carbonate electrolytes. The unusual passivation character of the concentrated electrolyte coupled with its fire-extinguishing property contributes to developing safe and long-lasting batteries, unlocking the limit toward development of much higher energy-density batteries.

The Spatial and Temporal Analysis of Steppe Fires in Lake Elton’s Area Based on RSD

Directory of Open Access Journals (Sweden)

Shinkarenko Stanislav Sergeevich

2015-04-01

Full Text Available The study analyzed the satellite imagery for the period of 1985-2014 in order to identify the causes of wildfires in Lake Elton’s surroundings. It was found that in the early 21st century fires have the greatest impact on the landscape, which is caused by the decrease in the number of livestock grazing and reduced steppe loads in the late 1990s. The map of the fire frequency in the researched area, and t he map of areas recovering from fires in different years were developed on the basis of remote sensing data (RSD. The investigation of Landsat space imagery found that 54 % of the territory since 2004 has been subject to a prairie fire at least once. The maximum frequency of occurrence is marked for the southern area of Buluhta-Lake where eight fires were registered for the last decad. Most fires are caused by human factors: deliberate or spontaneous arson, military trials. The factors limiting the fires are: degraded pastures, roads, landforms and the elements of the hydrological network. The resulting materials allow to effectively organize further ground survey of these areas for a complete description and assessment of revegetation and their relation to the duration of pyrogenic successions.

Does Spontaneous Favorability to Power (vs. Universalism) Values Predict Spontaneous Prejudice and Discrimination?

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Souchon, Nicolas; Maio, Gregory R; Hanel, Paul H P; Bardin, Brigitte

2017-10-01

We conducted five studies testing whether an implicit measure of favorability toward power over universalism values predicts spontaneous prejudice and discrimination. Studies 1 (N = 192) and 2 (N = 86) examined correlations between spontaneous favorability toward power (vs. universalism) values, achievement (vs. benevolence) values, and a spontaneous measure of prejudice toward ethnic minorities. Study 3 (N = 159) tested whether conditioning participants to associate power values with positive adjectives and universalism values with negative adjectives (or inversely) affects spontaneous prejudice. Study 4 (N = 95) tested whether decision bias toward female handball players could be predicted by spontaneous attitude toward power (vs. universalism) values. Study 5 (N = 123) examined correlations between spontaneous attitude toward power (vs. universalism) values, spontaneous importance toward power (vs. universalism) values, and spontaneous prejudice toward Black African people. Spontaneous positivity toward power (vs. universalism) values was associated with spontaneous negativity toward minorities and predicted gender bias in a decision task, whereas the explicit measures did not. These results indicate that the implicit assessment of evaluative responses attached to human values helps to model value-attitude-behavior relations. © 2016 The Authors. Journal of Personality Published by Wiley Periodicals, Inc.

Fire risk assessment in Germany. Procedure, data, results

International Nuclear Information System (INIS)

Berg, H.P.

2000-01-01

The recommended approach for a quantitative fire risk assessment to be applied within periodic safety reviews of nuclear power plants in Germany starts with a screening process providing critical fire zones and is followed by a quantitative analysis using a standard event tree with elements for fire initiation, ventilation of the room, fire detection, fire suppression, and fire propagation. In a final step, the fire induced frequency of initiating events, the main contributors and the calculated hazard state frequency for the fire event are determined. For that purpose, a comprehensive data base is needed which has been developed in particular for active fire protection measures. As an example results of one fire PSA are reported. (author)

Fire hazard analysis of the radioactive mixed waste trenchs

International Nuclear Information System (INIS)

McDonald, K.M.

1995-01-01

This Fire Hazards Analysis (FHA) is intended to assess comprehensively the risk from fire associated with the disposal of low level radioactive mixed waste in trenches within the lined landfills, provided by Project W-025, designated Trench 31 and 34 of the Burial Ground 218-W-5. Elements within the FHA make recommendations for minimizing risk to workers, the public, and the environment from fire during the course of the operation's activity. Transient flammables and combustibles present that support the operation's activity are considered and included in the analysis. The graded FHA contains the following elements: description of construction, protection of essential safety class equipment, fire protection features, description of fire hazards, life safety considerations, critical process equipment, high value property, damage potential--maximum credible fire loss (MCFL) and maximum possible fire loss (MPFL), fire department/brigade response, recovery potential, potential for a toxic, biological and/or radiation incident due to a fire, emergency planning, security considerations related to fire protection, natural hazards (earthquake, flood, wind) impact on fire safety, and exposure fire potential, including the potential for fire spread between fire areas. Recommendations for limiting risk are made in the text of this report and printed in bold type. All recommendations are repeated in a list in Section 18.0

Arginine vasopressin antagonizes the effects of prostaglandin E2 on the spontaneous activity of warm-sensitive and temperature-insensitive neurons in the medial preoptic area in rats.

Science.gov (United States)

Xu, Jian-Hui; Hou, Xiao-Yu; Tang, Yu; Luo, Rong; Zhang, Jie; Liu, Chang; Yang, Yong-Lu

2018-01-01

Arginine vasopressin (AVP) plays an important role in thermoregulation and antipyresis. We have demonstrated that AVP could change the spontaneous activity of thermosensitive and temperature insensitive neurons in the preoptic area. However, whether AVP influences the effects of prostaglandin E 2 (PGE 2 ) on the spontaneous activity of neurons in the medial preoptic area (MPO) remains unclear. Our experiment showed that PGE 2 decreased the spontaneous activity of warm-sensitive neurons, and increased that of low-slope temperature-insensitive neurons in the MPO. AVP attenuated the inhibitory effect of PGE 2 on warm-sensitive neurons, and reversed the excitatory effect of PGE 2 on low-slope temperature-insensitive neurons, demonstrating that AVP antagonized the effects of PGE 2 on the spontaneous activity of these neurons. The effect of AVP was suppressed by an AVP V 1a receptor antagonist, suggesting that V 1a receptor mediated the action of AVP. We also demonstrated that AVP attenuated the PGE 2 -induced decrease in the prepotential's rate of rise in warm-sensitive neurons and the PGE 2 -induced increase in that in low-slope temperature-insensitive neurons through the V 1a receptor. Together, these data indicated that AVP antagonized the PGE 2 -induced change in the spontaneous activity of warm-sensitive and low-slope temperature-insensitive neurons in the MPO partly by reducing the PGE 2 -induced change in the prepotential of these neurons in a V 1a receptor-dependent manner. Copyright © 2017 Elsevier B.V. All rights reserved.

Risk Insights Gained from Fire Incidents

International Nuclear Information System (INIS)

Kazarians, Mardy; Nowlen, Steven P.

1999-01-01

There now exist close to 20 years of history in the application of Probabilistic Risk Assessment (PRA) for the analysis of fire risk at nuclear power plants. The current methods are based on various assumptions regarding fire phenomena, the impact of fire on equipment and operator response, and the overall progression of a fire event from initiation through final resolution. Over this same time period, a number of significant fire incidents have occurred at nuclear power plants around the world. Insights gained from US experience have been used in US studies as the statistical basis for establishing fire initiation frequencies both as a function of the plant area and the initiating fire source.To a lesser extent, the fire experience has also been used to assess the general severity and duration of fires. However, aside from these statistical analyses, the incidents have rarely been scrutinized in detail to verify the underlying assumptions of fire PRAs. This paper discusses an effort, under which a set of fire incidents are being reviewed in order to gain insights directly relevant to the methods, data, and assumptions that form the basis for current fire PRAs. The paper focuses on the objectives of the effort, the specific fire events being reviews methodology, and anticipated follow-on activities