WorldWideScience

Sample records for sponsored high-sensitivity aerial

  1. High-Sensitivity Spectrophotometry.

    Science.gov (United States)

    Harris, T. D.

    1982-01-01

    Selected high-sensitivity spectrophotometric methods are examined, and comparisons are made of their relative strengths and weaknesses and the circumstances for which each can best be applied. Methods include long path cells, noise reduction, laser intracavity absorption, thermocouple calorimetry, photoacoustic methods, and thermo-optical methods.…

  2. Highly Sensitive Flash LADAR Camera, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — A highly sensitive 640 x 480-element flash LADAR camera will be developed that is capable of 100-Hz rates with better than 5-cm range precision. The design is based...

  3. 7 CFR 654.11 - Sponsor(s)' responsibility.

    Science.gov (United States)

    2010-01-01

    ...&M on land administered by that agency. If project measures benefit both Federal and non-Federal land... § 654.11 Sponsor(s)' responsibility. (a) On non-Federal land, sponsor(s) are responsible for financing and performing without cost to the Federal Government, needed operation and maintenance (O&M) of...

  4. High Sensitivity deflection detection of nanowires

    Energy Technology Data Exchange (ETDEWEB)

    Sanii, Babak; Ashby, Paul

    2009-10-28

    A critical limitation of nanoelectromechanical systems (NEMS) is the lack of a high-sensitivity position detection mechanism. We introduce a noninterferometric optical approach to determine the position of nanowires with a high sensitivity and bandwidth. Its physical origins and limitations are determined by Mie scattering analysis. This enables a dramatic miniaturization of detectable cantilevers, with attendant reductions to the fundamental minimum force noise in highly damping environments. We measure the force noise of an 81{+-}9??nm radius Ag{sub 2}Ga nanowire cantilever in water at 6{+-}3??fN/{radical}Hz.

  5. Aluminum nanocantilevers for high sensitivity mass sensors

    DEFF Research Database (Denmark)

    Davis, Zachary James; Boisen, Anja

    2005-01-01

    We have fabricated Al nanocantilevers using a simple, one mask contact UV lithography technique with lateral and vertical dimensions under 500 and 100 nm, respectively. These devices are demonstrated as highly sensitive mass sensors by measuring their dynamic properties. Furthermore, it is shown ...

  6. Committees and sponsors

    Science.gov (United States)

    2011-10-01

    International Advisory Committee Richard F CastenYale, USA Luiz Carlos ChamonSão Paulo, Brazil Osvaldo CivitareseLa Plata, Argentina Jozsef CsehATOMKI, Hungary Jerry P DraayerLSU, USA Alfredo Galindo-UribarriORNL & UT, USA James J KolataNotre Dame, USA Jorge López UTEP, USA Joseph B NatowitzTexas A & M, USA Ma Esther Ortiz IF-UNAM Stuart PittelDelaware, USA Andrés SandovalIF-UNAM Adam SzczepaniakIndiana, USA Piet Van IsackerGANIL, France Michael WiescherNotre Dame, USA Organizing Committee Libertad Barrón-Palos (Chair)IF-UNAM Roelof BijkerICN-UNAM Ruben FossionICN-UNAM David LizcanoININ Sponsors Instituto de Ciencias Nucleares, UNAMInstituto de Física, UNAMInstituto Nacional de Investigaciones NuclearesDivisión de Física Nuclear de la SMFCentro Latinoamericano de Física

  7. Thyroglobulin measurement by highly sensitive assays

    DEFF Research Database (Denmark)

    Giovanella, Luca; Feldt-Rasmussen, Ulla; Verburg, Frederik A

    2015-01-01

    of thyroglobulin (Tg), circulating Tg serves as a biochemical marker of persistent or recurrent disease in the follow-up of DTC. Due to the suboptimal clinical detection rate of older Tg assays endogenous or exogenous thyrotropin (TSH) stimulations are recommended for unmasking occult disease. However...... in current clinical guidelines, such assays are now increasingly used in clinical practice. As serum Tg measurement is a technically challenging assay and criteria to define a 'highly sensitive' assay may be different, a good knowledge of the technical difficulties and interpretation criteria is of paramount...

  8. Review of high-sensitivity Radon studies

    Science.gov (United States)

    Wojcik, M.; Zuzel, G.; Simgen, H.

    2017-10-01

    A challenge in many present cutting-edge particle physics experiments is the stringent requirements in terms of radioactive background. In peculiar, the prevention of Radon, a radioactive noble gas, which occurs from ambient air and it is also released by emanation from the omnipresent progenitor Radium. In this paper we review various high-sensitivity Radon detection techniques and approaches, applied in the experiments looking for rare nuclear processes happening at low energies. They allow to identify, quantitatively measure and finally suppress the numerous sources of Radon in the detectors’ components and plants.

  9. [Clinical interpretation of high sensitivity troponin T].

    Science.gov (United States)

    Alquézar Arbé, Aitor; Santaló Bel, Miguel; Sionis, Alessandro

    2015-09-21

    Determination of cardiac troponin (cTn) is necessary for the diagnosis of acute myocardial infarction without ST segment elevation. However Tnc can be released in other clinical situations. The development of high-sensitive cTn T assays (hs-cTnT) improves the management of patients with suspected acute coronary syndrome. Here, we provide an overview of the diverse causes of hs-cTnT elevation and recommend strategies for the clinical interpretation of the test result. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  10. Heterojunction phototransistor for highly sensitive infrared detection

    Science.gov (United States)

    Rezaei, Mohsen; Park, Min-Su; Tan, Chee Leong; Rabinowitz, Cobi; Wheaton, Skyler; Mohseni, Hooman

    2017-02-01

    In this work, we have proposed a model for the ultimate physical limit on the sensitivity of the heterojunction bipolar phototransistors (HPTs). Based on our modeling we have extracted the design criteria for the HPT for high sensitivity application. HPT with the submicron emitter and base area has the potential to be used for the low number photon resolving in near-infrared (NIR) wavelength. However, in practice, the quality of materials, processing, and the passivation plays an important role in the realization of the highly sensitive HPT. For short wave infrared (SWIR) HPTs based on lattice matched InGaAs to InP is studied. For these devices, conditions to reach to the highest possible sensitivity is examined. We have made an HPT based on InGaAs collector and base on the InP substrate. After developing proper processing combination of wet and dry etching and the surface passivation for the device we made an imager with 320x256 pixels based with a 30m pixel pitch. The imager shows the sensitivity less the 30 photons for each pixel with the frame rate more than 1K frames per second.

  11. High sensitivity troponin and valvular heart disease.

    Science.gov (United States)

    McCarthy, Cian P; Donnellan, Eoin; Phelan, Dermot; Griffin, Brian P; Enriquez-Sarano, Maurice; McEvoy, John W

    2017-07-01

    Blood-based biomarkers have been extensively studied in a range of cardiovascular diseases and have established utility in routine clinical care, most notably in the diagnosis of acute coronary syndrome (e.g., troponin) and the management of heart failure (e.g., brain-natriuretic peptide). The role of biomarkers is less well established in the management of valvular heart disease (VHD), in which the optimal timing of surgical intervention is often challenging. One promising biomarker that has been the subject of a number of recent VHD research studies is high sensitivity troponin (hs-cTn). Novel high-sensitivity assays can detect subclinical myocardial damage in asymptomatic individuals. Thus, hs-cTn may have utility in the assessment of asymptomatic patients with severe VHD who do not have a clear traditional indication for surgical intervention. In this state-of-the-art review, we examine the current evidence for hs-cTn as a potential biomarker in the most commonly encountered VHD conditions, aortic stenosis and mitral regurgitation. This review provides a synopsis of early evidence indicating that hs-cTn has promise as a biomarker in VHD. However, the impact of its measurement on clinical practice and VHD outcomes needs to be further assessed in prospective studies before routine clinical use becomes a reality. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Jointly Sponsored Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett A. Sondreal; John G. Hendrikson; Thomas A. Erickson

    2009-03-31

    U.S. Department of Energy (DOE) Cooperative Agreement DE-FC26-98FT40321 funded through the Office of Fossil Energy and administered at the National Energy Technology Laboratory (NETL) supported the performance of a Jointly Sponsored Research Program (JSRP) at the Energy & Environmental Research Center (EERC) with a minimum 50% nonfederal cost share to assist industry in commercializing and effectively applying highly efficient, nonpolluting energy systems that meet the nation's requirements for clean fuels, chemicals, and electricity in the 21st century. The EERC in partnership with its nonfederal partners jointly performed 131 JSRP projects for which the total DOE cost share was $22,716,634 (38%) and the nonfederal share was $36,776,573 (62%). Summaries of these projects are presented in this report for six program areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, and (6) advanced materials. The work performed under this agreement addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration; near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources.

  13. Highly sensitive microcalorimeters for radiation research

    International Nuclear Information System (INIS)

    Avaev, V.N.; Demchuk, B.N.; Ioffe, L.A.; Efimov, E.P.

    1984-01-01

    Calorimetry is used in research at various types of nuclear-physics installations to obtain information on the quantitative and qualitative composition of ionizing radiation in a reactor core and in the surrounding layers of the biological shield. In this paper, the authors examine the characteristics of highly sensitive microcalorimeters with modular semiconductor heat pickups designed for operation in reactor channels. The microcalorimeters have a thin-walled aluminum housing on whose inner surface modular heat pickups are placed radially as shown here. The results of measurements of the temperature dependence of the sensitivity of the microcalorimeters are shown. The results of measuring the sensitivity of a PMK-2 microcalorimeter assembly as a function of integrated neutron flux for three energy intervals and the adsorbed gamma energy are shown. In order to study specimens with different shapes and sizes, microcalorimeters with chambers in the form of cylinders and a parallelepiped were built and tested

  14. Heterogeneous catalysis in highly sensitive microreactors

    DEFF Research Database (Denmark)

    Olsen, Jakob Lind

    This thesis present a highly sensitive silicon microreactor and examples of its use in studying catalysis. The experimental setup built for gas handling and temperature control for the microreactor is described. The implementation of LabVIEW interfacing for all the experimental parts makes...... of adsorbates readily converted to methanol as the source of the transient increase in methanol production, is eliminated. A study of mass selected ruthenium nanoparticles from a magnetron-sputter gas-aggregation source, deposited in microreactors, is presented. It is, shown that CO methanation can be measured...... on the mass selected nanoparticles in the microreactor. A parameter study shows negative reaction order in the CO concentration and apparent acivation energies between 0.8 and 1.2 eV depending on reaction conditions. Temperature programmed reaction studies in H2m shows di_erent forms of carbon growth...

  15. Development of high sensitivity radon detectors

    CERN Document Server

    Takeuchi, Y; Kajita, T; Tasaka, S; Hori, H; Nemoto, M; Okazawa, H

    1999-01-01

    High sensitivity detectors for radon in air and in water have been developed. We use electrostatic collection and a PIN photodiode for these detectors. Calibration systems have been also constructed to obtain collection factors. As a result of the calibration study, the absolute humidity dependence of the radon detector for air is clearly observed in the region less than about 1.6 g/m sup 3. The calibration factors of the radon detector for air are 2.2+-0.2 (counts/day)/(mBq/m sup 3) at 0.08 g/m sup 3 and 0.86+-0.06 (counts/day)/(mBq/m sup 3) at 11 g/m sup 3. The calibration factor of the radon detector for water is 3.6+-0.5 (counts/day)/(mBq/m sup 3). The background level of the radon detector for air is 2.4+-1.3 counts/day. As a result, one standard deviation excess of the signal above the background of the radon detector for air should be possible for 1.4 mBq/m sup 3 in a one-day measurement at 0.08 g/m sup 3.

  16. LET Dependence of High Sensitivity TL Dosemeters

    International Nuclear Information System (INIS)

    Ranogajec-Komor, M.; Osvay, M.

    1998-01-01

    LET dependence of highly sensitive Al 2 O 3 :C (made in Russia) and CaF 2 :Mn (made in Slovenia) TL dosimeters was investigated using low (gamma) and high LET (alpha, neutron) exposures. Glow curve analysis was used to determine the efficiencies of TL light production for alpha particle and neutron irradiation relative to gamma exposure. The experiments were performed with 60 Co, 241 Am and 233 Pu-Be source using a 20 cm diameter polyethylene moderator. The irradiation dose was in the range 1-40 mGy for gamma and alpha irradiations and 1-40 mSv for neutron irradiation, respectively. Neither high temperature peak, nor significant change of the glow curve shape were found after irradiation by high LET radiations. Both detectors showed a linear response of TL signals in the dose range used. Gamma sensitivity of Al 2 O 3 :C as compared to CaF 2 :Mn was 6:1. Relative TL efficiency for alpha particle irradiation as compared to gamma exposure was about 0.03 and 0.18 for Al 2 O 3 :C and CaF 2 :Mn, respectively. Neutron sensitivity was found to be similar (about 0.04 as compared to gamma irradiation) for both materials. Results indicate that for both materials investigated the TL sensitivity decreases with increasing LET, moreover their glow curves do not possess peaks for selective assessment of low and high LET radiation dose separately. The relative high TL efficiency of CaF 2 :Mn for alpha particle irradiation and the unexpected split of its peak in two components suggests to plane further investigations to determine the effect of proton irradiation as well. (author)

  17. High sensitivity amplifier/discriminator for PWC's

    International Nuclear Information System (INIS)

    Hansen, S.

    1983-01-01

    The facility support group at Fermilab is designing and building a general purpose beam chamber for use in several locations at the laboratory. This pwc has 128 wires per plane spaced 1 mm apart. An initial production of 25 signal planes is anticipated. In proportional chambers, the size of the signal depends exponentially on the charge stored per unit of length along the anode wire. As the wire spacing decreases, the capacitance per unit length decreases, thereby requiring increased applied voltage to restore the necessary charge per unit length. In practical terms, this phenomenon is responsible for difficulties in constructing chambers with less than 2 mm wire spacing. 1 mm chambers, therefore, are frequently operated very near to their breakdown point and/or a high gain gas containing organic compounds such as magic gas is used. This argon/iso-butane mixture has three drawbacks: it is explosive when exposed to the air, it leaves a residue on the wires after extended use and is costly. An amplifier with higher sensitivity would reduce the problems associated with operating chambers with small wire spacings and allow them to be run a safe margin below their breakdown voltage even with an inorganic gas mixture such as argon/CO2, this eliminating the need to use magic gas. Described here is a low cost amplifier with a usable threshold of less than 0.5 μA. Data on the performance of this amplifier/discriminator in operation on a prototype beam chamber are given. This data shows the advantages of the high sensitivity of this design

  18. Employer-sponsored pension plans

    OpenAIRE

    Rakonjac-Antić Tatjana N.

    2004-01-01

    Apart from pension plans within social insurance, in developed pension systems there are also available to individuals schemes which may to a large extent ensure a significant part of their total pension. Among them are the following: employer-sponsored pension plans or individual pension plans. The most widely used employer-sponsored pension plan in the USA is 401(k), in which both the employer and the employee contribute to the financing of the pension. These contributions as well as the re...

  19. Employer-sponsored pension plans

    Directory of Open Access Journals (Sweden)

    Rakonjac-Antić Tatjana N.

    2004-01-01

    Full Text Available Apart from pension plans within social insurance, in developed pension systems there are also available to individuals schemes which may to a large extent ensure a significant part of their total pension. Among them are the following: employer-sponsored pension plans or individual pension plans. The most widely used employer-sponsored pension plan in the USA is 401(k, in which both the employer and the employee contribute to the financing of the pension. These contributions as well as the return to their investment have a preferential tax treatment, i.e. do not enter a tax base. The funds are taxed only when drawn from the account in the form of a pension. This paper aims to present the functioning of 401(k pension plan as the most widely used employer sponsored pension plan in the USA, which is likely, in a modified form, to have an important place within our future reformed pension insurance system.

  20. Development of a highly sensitive lithium fluoride thermoluminescence dosimeter

    International Nuclear Information System (INIS)

    Moraes da Silva, Teresinha de; Campos, Leticia Lucente

    1995-01-01

    In recent times, LiF: Mg, Cu, P thermoluminescent phosphor has been increasingly in use for radiation monitoring due its high sensitivity and ease of preparation. The Dosimetric Materials Production Laboratory of IPEN, (Nuclear Energy Institute) has developed a simple method to obtain high sensitivity LiF. The preparation method is described. (author). 4 refs., 1 fig., 1 tab

  1. AMRMS Aerial survey database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — An aerial monitoring program was conducted during the period 1962 - 2003 in cooperation with aerial spotters working for the commercial purse seine fleet. Flights...

  2. Aerial radiation surveys

    International Nuclear Information System (INIS)

    Jobst, J.

    1980-01-01

    A recent aerial radiation survey of the surroundings of the Vitro mill in Salt Lake City shows that uranium mill tailings have been removed to many locations outside their original boundary. To date, 52 remote sites have been discovered within a 100 square kilometer aerial survey perimeter surrounding the mill; 9 of these were discovered with the recent aerial survey map. Five additional sites, also discovered by aerial survey, contained uranium ore, milling equipment, or radioactive slag. Because of the success of this survey, plans are being made to extend the aerial survey program to other parts of the Salt Lake valley where diversions of Vitro tailings are also known to exist

  3. Compact, Robust, Low Power High Sensitivity Gas Sensor, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Miniaturized gas sensors with high sensitivity that are compact, low power and low weight are needed to support for NASA's airborne science missions, particularly...

  4. High sensitivity probe absorption technique for time-of-flight ...

    Indian Academy of Sciences (India)

    We report on a phase-sensitive probe absorption technique with high sensitivity, capable of detecting a few hundred ultra-cold atoms in flight in an observation time of a few milliseconds. The large signal-to-noise ratio achieved is sufficient for reliable measurements on low intensity beams of cold atoms. We demonstrate the ...

  5. Aluminum nano-cantilevers for high sensitivity mass sensors

    DEFF Research Database (Denmark)

    Davis, Zachary James; Boisen, Anja

    2005-01-01

    We have fabricated Al nano-cantilevers using a very simple one mask contact UV lithography technique with lateral dimensions under 500 nm and vertical dimensions of approximately 100 nm. These devices are demonstrated as highly sensitive mass sensors by measuring their dynamic properties. Further...

  6. Sponsors' participation in conduct and reporting of industry trials

    DEFF Research Database (Denmark)

    Lundh, Andreas; Krogsbøll, Lasse T; Gøtzsche, Peter C

    2012-01-01

    Bias in industry-sponsored trials is common and the interpretation of the results can be particularly distorted in favour of the sponsor's product. We investigated sponsors' involvement in the conduct and reporting of industry-sponsored trials.......Bias in industry-sponsored trials is common and the interpretation of the results can be particularly distorted in favour of the sponsor's product. We investigated sponsors' involvement in the conduct and reporting of industry-sponsored trials....

  7. Highly sensitive troponin T in patients with acute ischemic stroke

    DEFF Research Database (Denmark)

    Jensen, J K; Ueland, T; Aukrust, P

    2012-01-01

    in decedents than in survivors. After adjustment for stroke severity, C-reactive protein, age, NT-proBNP and prior heart and/or renal failure, hsTnT levels were not a significant predictor of long-term all-cause or cardiovascular mortality. Conclusion: Elevated levels of hsTnT are frequently present......Background: Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke. Methods: Highly...... sensitive troponin T (hsTnT) was measured daily during the first 4 days in 193 consecutive patients with acute ischemic stroke without overt ACS or atrial fibrillation. The patients were previously tested normal with a fourth-generation TnT assay. The patients were followed for 47 months, with all...

  8. Performance of terahertz metamaterials as high-sensitivity sensor

    Science.gov (United States)

    He, Yanan; Zhang, Bo; Shen, Jingling

    2017-09-01

    A high-sensitivity sensor based on the resonant transmission characteristics of terahertz (THz) metamaterials was investigated, with the proposal and fabrication of rectangular bar arrays of THz metamaterials exhibiting a period of 180 μm on a 25 μm thick flexible polyimide. Varying the size of the metamaterial structure revealed that the length of the rectangular unit modulated the resonant frequency, which was verified by both experiment and simulation. The sensing characteristics upon varying the surrounding media in the sample were tested by simulation and experiment. Changing the surrounding medium from that of air to that of alcohol or oil produced resonant frequency redshifts of 80 GHz or 150 GHz, respectively, which indicates that the sensor possessed a high sensitivity of 667 GHz per unit of refractive index. Finally, the influence of the sample substrate thickness on the sensor sensitivity was investigated by simulation. It may be a reference for future sensor design.

  9. Horizontal film balance having wide range and high sensitivity

    Science.gov (United States)

    Abraham, B.M.; Miyano, K.; Ketterson, J.B.

    1983-11-08

    A thin-film, horizontal balance instrument is provided for measuring surface tension (surface energy) of thin films suspended on a liquid substrate. The balance includes a support bearing and an optical feedback arrangement for wide-range, high sensitivity measurements. The force on the instrument is balanced by an electromagnet, the current through the magnet providing a measure of the force applied to the instrument. A novel float construction is also disclosed. 5 figs.

  10. Online high sensitivity measurement system for transuranic aerosols

    International Nuclear Information System (INIS)

    Kordas, J.F.; Phelps, P.L.

    1976-01-01

    A measurement system for transuranic aerosols has been designed that will be able to withstand the corrosive nature of stack effluents and yet have extremely high sensitivity. It will be capable of measuring 1 maximum permissible concentration (MPC) of plutonium or americium in 30 minutes with a fractional standard deviation of less than 0.33. Background resulting from 218 Po is eliminated by alpha energy discrimination and a decay scheme analysis. A microprocessor controls all data acquisition, data reduction, and instrument calibration

  11. Standardized Technical Data Survey (STDS) for Aerial Refueling

    Science.gov (United States)

    2016-09-06

    Director 1011 Ankeney Road Xenia OH 45385 8. PERFORMING ORGANIZATION REPORT NUMBER ARSAG Document # 17-81-03R 9. SPONSORING/ MONITORING AGENCY NAME(S) AND...are listed below to assist distribution: Aerial Refueling System Mechanical Electrical/ Electronic Fuel System Crew Stations Hydraulics/Pneumatics...is IDS triggered e.g. second detent on disconnect switch Click here to enter text. a Provide illustration or description of tanker and boom markings

  12. SPONSORING, BRAND VALUE AND SOCIAL MEDIA

    Directory of Open Access Journals (Sweden)

    Alexander Zauner

    2012-10-01

    Full Text Available The increasing involvement of individuals in social media over the past decade has enabled firms to pursue new avenues in communication and sponsoring activities. Besides general research on either social media or sponsoring, questions regarding the consequences of a joint activity (sponsoring activities in social media remain unexplored. Hence, the present study analyses whether the perceived image of the brand and the celebrity endorser credibility of a top sports team influence the perceived brand value of the sponsoring firm in a social media setting. Moreover, these effects are compared between existing customers and non-customers of the sponsoring firm. Interestingly, perceived celebrity endorser credibility plays no role in forming brand value perceptions in the case of the existing customers. Implications for marketing theory and practice are derived.

  13. Paradigma Baru Sponsor sebagai Mitra Penyelenggaraan Event

    Directory of Open Access Journals (Sweden)

    Lidia Evelina

    2011-10-01

    Full Text Available The goals of this article is to know why sponsorship only to be viewed as sources of funding to implement the public relation events or marketing communication events. Method used in this article is qualitative method research to be based on observation, library study and content analysis. The result of this research seems that change happened in role of sponsorship from only fund source to become a partner of cooperation (mutual symbiotism between sponsor and event organizer. This article exploring the change of sponsorship concept from only looking for sponsor as an activity of fund mobilitation to become a partnership cooperation between event organizer and sponsor company. The mean of sponsor itself beside the fund supporter, they are also a side who takes mutual benefit from the cooperation. Conclusion, any close relationship (mutual benefit between two sides who take cooperation in event implementation (sponsor and event organiser. 

  14. Compliant Aerial Manipulators

    DEFF Research Database (Denmark)

    Bartelds, T.; Capra, A.; Hamaza, S.

    2016-01-01

    This letter focuses on the problem of handling impacts by means of an aerial manipulator and proposes a solution that combines the control of the aerial manipulator's end-effector position with an innovative design approach of aerial manipulation systems, consisting of both active and passive...... joints. The approach aims at limiting the influence of impacts on the controlled attitude dynamics in order to allow the aerial manipulator to remain stable during and after impact. The developed concept is intended to convert kinetic energy into potential energy, which is permanently stored into elastic...... elements by means of directional locking mechanisms. The proposed approach has been tested on a 2 d.o.f. manipulator mounted on a quadrotor UAV. The manipulation system has one active rotational d.o.f. compensating for pitch movements of the UAV and one passive linear joint which is in charge of absorbing...

  15. Observatory Sponsoring Astronomical Image Contest

    Science.gov (United States)

    2005-05-01

    Forget the headphones you saw in the Warner Brothers thriller Contact, as well as the guttural throbs emanating from loudspeakers at the Very Large Array in that 1997 movie. In real life, radio telescopes aren't used for "listening" to anything - just like visible-light telescopes, they are used primarily to make images of astronomical objects. Now, the National Radio Astronomy Observatory (NRAO) wants to encourage astronomers to use radio-telescope data to make truly compelling images, and is offering cash prizes to winners of a new image contest. Radio Galaxy Fornax A Radio Galaxy Fornax A Radio-optical composite image of giant elliptical galaxy NGC 1316, showing the galaxy (center), a smaller companion galaxy being cannibalized by NGC 1316, and the resulting "lobes" (orange) of radio emission caused by jets of particles spewed from the core of the giant galaxy Click on image for more detail and images CREDIT: Fomalont et al., NRAO/AUI/NSF "Astronomy is a very visual science, and our radio telescopes are capable of producing excellent images. We're sponsoring this contest to encourage astronomers to make the extra effort to turn good images into truly spectacular ones," said NRAO Director Fred K.Y. Lo. The contest, offering a grand prize of $1,000, was announced at the American Astronomical Society's meeting in Minneapolis, Minnesota. The image contest is part of a broader NRAO effort to make radio astronomical data and images easily accessible and widely available to scientists, students, teachers, the general public, news media and science-education professionals. That effort includes an expanded image gallery on the observatory's Web site. "We're not only adding new radio-astronomy images to our online gallery, but we're also improving the organization and accessibility of the images," said Mark Adams, head of education and public outreach (EPO) at NRAO. "Our long-term goal is to make the NRAO Image Gallery an international resource for radio astronomy imagery

  16. Ultra-High-Sensitivity Aerosol Spectrometer (UHSAS) Instrument Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Uin, Janek [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-04-01

    The Ultra-High-Sensitivity Aerosol Spectrometer (UHSAS) (Figure 1) is an optical-scattering, laser-based aerosol particle spectrometer system for sizing particles in the 60 to 1000 nanometer (nm) range [1–3]. The instrument counts particles in up to 100 user-specified sizing bins. The instrument’s laser illuminates particles, which scatter light. The system captures the peak light signals that are generated. These signals are used for particle sizing, since the amount of light scattered correlates strongly with particle size.

  17. Electrooptic modulation methods for high sensitivity tunable diode laser spectroscopy

    Science.gov (United States)

    Glenar, David A.; Jennings, Donald E.; Nadler, Shacher

    1990-01-01

    A CdTe phase modulator and low power RF sources have been used with Pb-salt tunable diode lasers operating near 8 microns to generate optical sidebands for high sensitivity absorption spectroscopy. Sweep averaged, first-derivative sample spectra of CH4 were acquired by wideband phase sensitive detection of the electrooptically (EO) generated carrier-sideband beat signal. EO generated beat signals were also used to frequency lock the TDL to spectral lines. This eliminates low frequency diode jitter, and avoids the excess laser linewidth broadening that accompanies TDL current modulation frequency locking methods.

  18. Highly Sensitive Flexible Magnetic Sensor Based on Anisotropic Magnetoresistance Effect.

    Science.gov (United States)

    Wang, Zhiguang; Wang, Xinjun; Li, Menghui; Gao, Yuan; Hu, Zhongqiang; Nan, Tianxiang; Liang, Xianfeng; Chen, Huaihao; Yang, Jia; Cash, Syd; Sun, Nian-Xiang

    2016-11-01

    A highly sensitive flexible magnetic sensor based on the anisotropic magnetoresistance effect is fabricated. A limit of detection of 150 nT is observed and excellent deformation stability is achieved after wrapping of the flexible sensor, with bending radii down to 5 mm. The flexible AMR sensor is used to read a magnetic pattern with a thickness of 10 μm that is formed by ferrite magnetic inks. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. CHARM2000 (Future of High-Sensitivity Charm Experiments)

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    The fourth quark, charm, may not hit the headlines these days as much as its heavier cousins, but it has still a lot of physics to give. From June 7-9 over 100 attendees heard 35 plenary talks at Fermilab on the Future of High-Sensitivity Charm Experiments. Twelve working groups focused on the physics opportunities and technical challenges. Speakers representing the CLEO (Cornell), BES (Beijing), SLAC B-Factory, Fermilab E653, E687/831, E769/791, E781, and CERN WA82/92 and WA89 collaborations reviewed the current status and future prospects.

  20. High sensitivity of positron annihilation to thermal oxidation of polyethylene

    Science.gov (United States)

    Ito, Kenji; Kobayashi, Yoshinori; Nanasawa, Atsushi

    2003-01-01

    We demonstrate the high sensitivity of positron annihilation to compositional changes related to the thermal degradation of polyethylene (PE). Positron annihilation γ-ray and lifetime measurements were conducted for PE films with and without antioxidant (1000-ppm Ciba® IRGANOX® 1076), subjected to heat treatment at 100 °C for different periods, to a maximum of 30 days. For the film without antioxidant, the positron Doppler parameter (S) and ortho-positronium formation probability (Io-Ps) appreciably decreased with increased heat treatment times, whereas they barely changed for the film with antioxidant. This, together with the Fourier transform infrared measurements, demonstrated that the variations of S and Io-Ps are caused by the thermal oxidation of PE. The S parameter was found to be sensitive to the early stage of degradation, where the carbonyl concentration is inferred to be lower than 100 ppm. The high sensitivity results from the large positron mobility in PE and from the high positron affinity of oxygen-containing polar groups. This work provides the basis for an application of positron annihilation to sensitive detection of the initial degradation of PE and other nonpolar polymers.

  1. Design of highly sensitive multichannel bimetallic photonic crystal fiber biosensor

    Science.gov (United States)

    Hameed, Mohamed Farhat O.; Alrayk, Yassmin K. A.; Shaalan, Abdelhamid A.; El Deeb, Walid S.; Obayya, Salah S. A.

    2016-10-01

    A design of a highly sensitive multichannel biosensor based on photonic crystal fiber is proposed and analyzed. The suggested design has a silver layer as a plasmonic material coated by a gold layer to protect silver oxidation. The reported sensor is based on detection using the quasi transverse electric (TE) and quasi transverse magnetic (TM) modes, which offers the possibility of multichannel/multianalyte sensing. The numerical results are obtained using a finite element method with perfect matched layer boundary conditions. The sensor geometrical parameters are optimized to achieve high sensitivity for the two polarized modes. High-refractive index sensitivity of about 4750 nm/RIU (refractive index unit) and 4300 nm/RIU with corresponding resolutions of 2.1×10-5 RIU, and 2.33×10-5 RIU can be obtained according to the quasi TM and quasi TE modes of the proposed sensor, respectively. Further, the reported design can be used as a self-calibration biosensor within an unknown analyte refractive index ranging from 1.33 to 1.35 with high linearity and high accuracy. Moreover, the suggested biosensor has advantages in terms of compactness and better integration of microfluidics setup, waveguide, and metallic layers into a single structure.

  2. Fast Aerial Video Stitching

    Directory of Open Access Journals (Sweden)

    Jing Li

    2014-10-01

    Full Text Available The highly efficient and robust stitching of aerial video captured by unmanned aerial vehicles (UAVs is a challenging problem in the field of robot vision. Existing commercial image stitching systems have seen success with offline stitching tasks, but they cannot guarantee high-speed performance when dealing with online aerial video sequences. In this paper, we present a novel system which has an unique ability to stitch high-frame rate aerial video at a speed of 150 frames per second (FPS. In addition, rather than using a high-speed vision platform such as FPGA or CUDA, our system is running on a normal personal computer. To achieve this, after the careful comparison of the existing invariant features, we choose the FAST corner and binary descriptor for efficient feature extraction and representation, and present a spatial and temporal coherent filter to fuse the UAV motion information into the feature matching. The proposed filter can remove the majority of feature correspondence outliers and significantly increase the speed of robust feature matching by up to 20 times. To achieve a balance between robustness and efficiency, a dynamic key frame-based stitching framework is used to reduce the accumulation errors. Extensive experiments on challenging UAV datasets demonstrate that our approach can break through the speed limitation and generate an accurate stitching image for aerial video stitching tasks.

  3. High-Sensitivity Temperature-Independent Silicon Photonic Microfluidic Biosensors

    Science.gov (United States)

    Kim, Kangbaek

    Optical biosensors that can precisely quantify the presence of specific molecular species in real time without the need for labeling have seen increased use in the drug discovery industry and molecular biology in general. Of the many possible optical biosensors, the TM mode Si biosensor is shown to be very attractive in the sensing application because of large field amplitude on the surface and cost effective CMOS VLSI fabrication. Noise is the most fundamental factor that limits the performance of sensors in development of high-sensitivity biosensors, and noise reduction techniques require precise studies and analysis. One such example stems from thermal fluctuations. Generally SOI biosensors are vulnerable to ambient temperature fluctuations because of large thermo-optic coefficient of silicon (˜2x10 -4 RIU/K), typically requiring another reference ring and readout sequence to compensate temperature induced noise. To address this problem, we designed sensors with a novel TM-mode shallow-ridge waveguide that provides both large surface amplitude for bulk and surface sensing. With proper design, this also provides large optical confinement in the aqueous cladding that renders the device athermal using the negative thermo-optic coefficient of water (~ --1x10-4RIU/K), demonstrating cancellation of thermo-optic effects for aqueous solution operation near 300K. Additional limitations resulting from mechanical actuator fluctuations, stability of tunable lasers, and large 1/f noise of lasers and sensor electronics can limit biosensor performance. Here we also present a simple harmonic feedback readout technique that obviates the need for spectrometers and tunable lasers. This feedback technique reduces the impact of 1/f noise to enable high-sensitivity, and a DSP lock-in with 256 kHz sampling rate can provide down to micros time scale monitoring for fast transitions in biomolecular concentration with potential for small volume and low cost. In this dissertation, a novel

  4. Aerial radiation survey

    International Nuclear Information System (INIS)

    Pradeep Kumar, K.S.

    1998-01-01

    Aerial gamma spectrometry surveys are the most effective, comprehensive and preferred tool to delimit the large area surface contamination in a radiological emergency either due to a nuclear accident or following a nuclear strike. The airborne survey apart from providing rapid and economical evaluation of ground contamination over large areas due to larger ground clearance and higher speed, is the only technique to overcome difficulties posed by ground surveys of inaccessible region. The aerial survey technique can also be used for searching of lost radioactive sources, tracking of radioactive plume and generation of background data on the Emergency Planning Zone (EPZ) of nuclear installations

  5. BH3105 type neutron dose equivalent meter of high sensitivity

    International Nuclear Information System (INIS)

    Ji Changsong; Zhang Enshan; Yang Jianfeng; Zhang Hong; Huang Jiling

    1995-10-01

    It is noted that to design a neutron dose meter of high sensitivity is almost impossible in the frame of traditional designing principle--'absorption net principle'. Based on a newly proposed principle of obtaining neutron dose equi-biological effect adjustment--' absorption stick principle', a brand-new neutron dose-equivalent meter with high neutron sensitivity BH3105 has been developed. Its sensitivity reaches 10 cps/(μSv·h -1 ), which is 18∼40 times higher than one of foreign products of the same kind and is 10 4 times higher than that of domestic FJ342 neutron rem-meter. BH3105 has a measurement range from 0.1μSv/h to 1 Sv/h which is 1 or 2 orders wider than that of the other's. It has the advanced properties of gamma-resistance, energy response, orientation, etc. (6 tabs., 5 figs.)

  6. A high sensitivity nanomaterial based SAW humidity sensor

    Energy Technology Data Exchange (ETDEWEB)

    Wu, T-T; Chou, T-H [Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan (China); Chen, Y-Y [Department of Mechanical Engineering, Tatung University, Taipei 104, Taiwan (China)], E-mail: wutt@ndt.iam.ntu.edu.tw

    2008-04-21

    In this paper, a highly sensitive humidity sensor is reported. The humidity sensor is configured by a 128{sup 0}YX-LiNbO{sub 3} based surface acoustic wave (SAW) resonator whose operating frequency is at 145 MHz. A dual delay line configuration is realized to eliminate external temperature fluctuations. Moreover, for nanostructured materials possessing high surface-to-volume ratio, large penetration depth and fast charge diffusion rate, camphor sulfonic acid doped polyaniline (PANI) nanofibres are synthesized by the interfacial polymerization method and further deposited on the SAW resonator as selective coating to enhance sensitivity. The humidity sensor is used to measure various relative humidities in the range 5-90% at room temperature. Results show that the PANI nanofibre based SAW humidity sensor exhibits excellent sensitivity and short-term repeatability.

  7. Development of High Sensitivity Nuclear Emulsion and Fine Grained Emulsion

    Science.gov (United States)

    Kawahara, H.; Asada, T.; Naka, T.; Naganawa, N.; Kuwabara, K.; Nakamura, M.

    2014-08-01

    Nuclear emulsion is a particle detector having high spacial resolution and angular resolution. It became useful for large statistics experiment thanks to the development of automatic scanning system. In 2010, a facility for emulsion production was introduced and R&D of nuclear emulsion began at Nagoya university. In this paper, we present results of development of the high sensitivity emulsion and fine grained emulsion for dark matter search experiment. Improvement of sensitivity is achieved by raising density of silver halide crystals and doping well-adjusted amount of chemicals. Production of fine grained emulsion was difficult because of unexpected crystal condensation. By mixing polyvinyl alcohol (PVA) to gelatin as a binder, we succeeded in making a stable fine grained emulsion.

  8. Development of High Sensitivity Nuclear Emulsion and Fine Grained Emulsion

    Energy Technology Data Exchange (ETDEWEB)

    Kawahara, H.; Asada, T. [Department of Physics, Nagoya University, Nagoya 464-8602 (Japan); Naka, T. [Institute of Advanced Research, Nagoya University (Japan); Naganawa, N.; Kuwabara, K.; Nakamura, M. [Department of Physics, Nagoya University, Nagoya 464-8602 (Japan)

    2014-08-15

    Nuclear emulsion is a particle detector having high spacial resolution and angular resolution. It became useful for large statistics experiment thanks to the development of automatic scanning system. In 2010, a facility for emulsion production was introduced and R and D of nuclear emulsion began at Nagoya university. In this paper, we present results of development of the high sensitivity emulsion and fine grained emulsion for dark matter search experiment. Improvement of sensitivity is achieved by raising density of silver halide crystals and doping well-adjusted amount of chemicals. Production of fine grained emulsion was difficult because of unexpected crystal condensation. By mixing polyvinyl alcohol (PVA) to gelatin as a binder, we succeeded in making a stable fine grained emulsion.

  9. Phase sensitive diffraction sensor for high sensitivity refractive index measurement

    Science.gov (United States)

    Kumawat, Nityanand; Varma, Manoj; Kumar, Sunil

    2018-02-01

    In this study a diffraction based sensor has been developed for bio molecular sensing applications and performing assays in real time. A diffraction grating fabricated on a glass substrate produced diffraction patterns both in transmission and reflection when illuminated by a laser diode. We used zeroth order I(0,0) as reference and first order I(0,1) as signal channel and conducted ratiometric measurements that reduced noise by more than 50 times. The ratiometric approach resulted in a very simple instrumentation with very high sensitivity. In the past, we have shown refractive index measurements both for bulk and surface adsorption using the diffractive self-referencing approach. In the current work we extend the same concept to higher diffraction orders. We have considered order I(0,1) and I(1,1) and performed ratiometric measurements I(0,1)/I(1,1) to eliminate the common mode fluctuations. Since orders I(0,1) and I(1,1) behaved opposite to each other, the resulting ratio signal amplitude increased more than twice compared to our previous results. As a proof of concept we used different salt concentrations in DI water. Increased signal amplitude and improved fluid injection system resulted in more than 4 times improvement in detection limit, giving limit of detection 1.3×10-7 refractive index unit (RIU) compared to our previous results. The improved refractive index sensitivity will help significantly for high sensitivity label free bio sensing application in a very cost-effective and simple experimental set-up.

  10. Effective dose calculation in CT using high sensitivity TLDs

    International Nuclear Information System (INIS)

    Brady, Z.; Johnston, P.N.

    2010-01-01

    Full text: To determine the effective dose for common paediatric CT examinations using thermoluminescence dosimetry (TLD) mea surements. High sensitivity TLD chips (LiF:Mg,Cu,P, TLD-IOOH, Thermo Fisher Scientific, Waltham, MA) were calibrated on a linac at an energy of 6 MY. A calibration was also performed on a superricial X-ray unit at a kilovoltage energy to validate the megavoltage cali bration for the purpose of measuring doses in the diagnostic energy range. The dose variation across large organs was assessed and a methodology for TLD placement in a 10 year old anthropomorphic phantom developed. Effective dose was calculated from the TLD measured absorbed doses for typical CT examinations after correcting for the TLD energy response and taking into account differences in the mass energy absorption coefficients for different tissues and organs. Results Using new tissue weighting factors recommended in ICRP Publication 103, the effective dose for a CT brain examination on a 10 year old was 1.6 millisieverts (mSv), 4.9 mSv for a CT chest exa ination and 4.7 mSv for a CT abdomen/pelvis examination. These values are lower for the CT brain examination, higher for the CT chest examination and approximately the same for the CT abdomen/ pelvis examination when compared with effective doses calculated using ICRP Publication 60 tissue weighting factors. Conclusions High sensitivity TLDs calibrated with a radiotherapy linac are useful for measuring dose in the diagnostic energy range and overcome limitations of output reproducibility and uniformity asso ciated with traditional TLD calibration on CT scanners or beam quality matched diagnostic X-ray units.

  11. Field test investigation of high sensitivity fiber optic seismic geophone

    Science.gov (United States)

    Wang, Meng; Min, Li; Zhang, Xiaolei; Zhang, Faxiang; Sun, Zhihui; Li, Shujuan; Wang, Chang; Zhao, Zhong; Hao, Guanghu

    2017-10-01

    Seismic reflection, whose measured signal is the artificial seismic waves ,is the most effective method and widely used in the geophysical prospecting. And this method can be used for exploration of oil, gas and coal. When a seismic wave travelling through the Earth encounters an interface between two materials with different acoustic impedances, some of the wave energy will reflect off the interface and some will refract through the interface. At its most basic, the seismic reflection technique consists of generating seismic waves and measuring the time taken for the waves to travel from the source, reflect off an interface and be detected by an array of geophones at the surface. Compared to traditional geophones such as electric, magnetic, mechanical and gas geophone, optical fiber geophones have many advantages. Optical fiber geophones can achieve sensing and signal transmission simultaneously. With the development of fiber grating sensor technology, fiber bragg grating (FBG) is being applied in seismic exploration and draws more and more attention to its advantage of anti-electromagnetic interference, high sensitivity and insensitivity to meteorological conditions. In this paper, we designed a high sensitivity geophone and tested its sensitivity, based on the theory of FBG sensing. The frequency response range is from 10 Hz to 100 Hz and the acceleration of the fiber optic seismic geophone is over 1000pm/g. sixteen-element fiber optic seismic geophone array system is presented and the field test is performed in Shengli oilfield of China. The field test shows that: (1) the fiber optic seismic geophone has a higher sensitivity than the traditional geophone between 1-100 Hz;(2) The low frequency reflection wave continuity of fiber Bragg grating geophone is better.

  12. Determination of the Actual Land Use Pattern Using Unmanned Aerial Vehicles and Multispectral Camera

    Science.gov (United States)

    Dindaroğlu, T.; Gündoğan, R.; Gülci, S.

    2017-11-01

    The international initiatives developed in the context of combating global warming are based on the monitoring of Land Use, Land Use Changes, and Forests (LULUCEF). Determination of changes in land use patterns is used to determine the effects of greenhouse gas emissions and to reduce adverse effects in subsequent processes. This process, which requires the investigation and control of quite large areas, has undoubtedly increased the importance of technological tools and equipment. The use of carrier platforms and commercially cheaper various sensors have become widespread. In this study, multispectral camera was used to determine the land use pattern with high sensitivity. Unmanned aerial flights were carried out in the research fields of Kahramanmaras Sutcu Imam University campus area. Unmanned aerial vehicle (UAV) (multi-propeller hexacopter) was used as a carrier platform for aerial photographs. Within the scope of this study, multispectral cameras were used to determine the land use pattern with high sensitivity.

  13. Persistent Aerial Tracking

    KAUST Repository

    Mueller, Matthias

    2016-04-13

    In this thesis, we propose a new aerial video dataset and benchmark for low altitude UAV target tracking, as well as, a photo-realistic UAV simulator that can be coupled with tracking methods. Our benchmark provides the rst evaluation of many state of-the-art and popular trackers on 123 new and fully annotated HD video sequences captured from a low-altitude aerial perspective. Among the compared trackers, we determine which ones are the most suitable for UAV tracking both in terms of tracking accuracy and run-time. We also present a simulator that can be used to evaluate tracking algorithms in real-time scenarios before they are deployed on a UAV "in the field", as well as, generate synthetic but photo-realistic tracking datasets with free ground truth annotations to easily extend existing real-world datasets. Both the benchmark and simulator will be made publicly available to the vision community to further research in the area of object tracking from UAVs. Additionally, we propose a persistent, robust and autonomous object tracking system for unmanned aerial vehicles (UAVs) called Persistent Aerial Tracking (PAT). A computer vision and control strategy is applied to a diverse set of moving objects (e.g. humans, animals, cars, boats, etc.) integrating multiple UAVs with a stabilized RGB camera. A novel strategy is employed to successfully track objects over a long period, by \\'handing over the camera\\' from one UAV to another. We integrate the complete system into an off-the-shelf UAV, and obtain promising results showing the robustness of our solution in real-world aerial scenarios.

  14. The Political Economy of Federally Sponsored Data

    Directory of Open Access Journals (Sweden)

    Bart Ragon

    2013-11-01

    Full Text Available Librarian involvement in the Open Access (OA movement has traditionally focused on access to scholarly publications. Recent actions by the White House have focused attention on access on the data produced from federally sponsored research. Questions have emerged concerning access to the output of federally sponsored research and whether it is a public or private good. Understanding the political battle over access to federally funded research is closely tied to the ownership of the peer review process in higher education and associated revenue streams, and as a result, interest groups seeking to influence government regulation have politicized the issues. As a major funder of research in higher education, policies from the federal government are likely to drive change in research practices at higher education institutions and impact library services. The political economy of federally sponsored research data will shape research enterprises in higher education inspire a number of new services distributed throughout the research life cycle.

  15. High sensitivity Moire interferometry with phase shifting at nano resolution

    Science.gov (United States)

    Chen, Bicheng

    Due to insatiate demand for miniaturization of electronics, there is a need for new techniques to measure full-field strain at micro-scale structures. In addition, Micro-Electronic-Mechanical-Systems (MEMS) require a high resolution and high sensitivity material property characterization technique. In this study, a theoretic model for a high sensitivity Moire Interferometry (MI) for measuring nano-scale strain field has been developed. The study also includes the application of the proposed measurement technique for the study of reliability of next generation nano-electronics/power electronics. The study includes both theoretical and experimental work. In the theoretical part, a far field modeling of a Moire Interferometer (MI) using the mode decomposition method is proposed according to the analytical formulation from the scalar diffraction theory. The wave propagation within the defined MI far field domain is solved analytically for a single frequency surface relieved grating structure following the Rayleigh-Sommerfeld formulation under the paraxial approximation. It is shown that the far-field electrical field and the intensity interferogram can be calculated using the mode decomposition method. Furthermore, the near-field (propagation distance EM) theory; and the EM fields are simulated in a few microns region above the surface of the diffraction grating. The study shows that there is a strong correlation (correlation factor R = 0.869) of spatial frequency response between EM field and strain field at the nanoscale. Experimentally, a 164 nm/pixel spatial resolution Moire Interferometer with automated full strain field calculation is proposed. Accurate full strain field maps are generated automatically by a combination of phase shifting technique (temporal data redundancy) and Continuous Wavelet Transform (CWT) (spatial data redundancy). A thermal experiment on BGA packaging is used to demonstrate the advantages of the proposed new design. To enhance the

  16. 77 FR 26697 - New Animal Drugs; Change of Sponsor; Change of Sponsor Address; Change of Sponsor Name and...

    Science.gov (United States)

    2012-05-07

    ... that it has transferred ownership of, and all rights and interest in, abbreviated new animal drug... HUMAN SERVICES Food and Drug Administration 21 CFR Parts 510 and 522 New Animal Drugs; Change of Sponsor... Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA) is amending the animal...

  17. Pulsed Discharge Helium Ionization Detector for Highly Sensitive Aquametry.

    Science.gov (United States)

    Mowry, Curtis D; Pimentel, Adam S; Sparks, Elizabeth S; Moorman, Matthew W; Achyuthan, Komandoor E; Manginell, Ronald P

    2016-01-01

    Trace moisture quantitation is crucial in medical, civilian and military applications. Current aquametry technologies are limited by the sample volume, reactivity, or interferences, and/or instrument size, weight, power, cost, and complexity. We report for the first time on the use of a pulsed discharge helium ionization detector (PDHID-D2) (∼196 cm(3)) for the sensitive (limit of detection, 0.047 ng; 26 ppm), linear (r(2) >0.99), and rapid (volume of liquid or gas. The relative humidity sensitivity was 0.22% (61.4 ppmv) with a limit of detection of less than 1 ng moisture with gaseous samples. The sensitivity was 10 to 100 to fold superior to competing technologies without the disadvantages inherent to these technologies. The PDHID-D2, due to its small footprint and low power requirement, has good size, weight, and power-portability (SWAPP) factors. The relatively low cost (∼$5000) and commercial availability of the PDHID-D2 makes our technique applicable to highly sensitive aquametry.

  18. Nanoparticle-Structured Highly Sensitive and Anisotropic Gauge Sensors.

    Science.gov (United States)

    Zhao, Wei; Luo, Jin; Shan, Shiyao; Lombardi, Jack P; Xu, Yvonne; Cartwright, Kelly; Lu, Susan; Poliks, Mark; Zhong, Chuan-Jian

    2015-09-16

    The ability to tune gauge factors in terms of magnitude and orientation is important for wearable and conformal electronics. Herein, a sensor device is described which is fabricated by assembling and printing molecularly linked thin films of gold nanoparticles on flexible microelectrodes with unusually high and anisotropic gauge factors. A sharp difference in gauge factors up to two to three orders of magnitude between bending perpendicular (B(⊥)) and parallel (B(||)) to the current flow directions is observed. The origin of the unusual high and anisotropic gauge factors is analyzed in terms of nanoparticle size, interparticle spacing, interparticle structure, and other parameters, and by considering the theoretical aspects of electron conduction mechanism and percolation pathway. A critical range of resistivity where a very small change in strain and the strain orientation is identified to impact the percolation pathway in a significant way, leading to the high and anisotropic gauge factors. The gauge anisotropy stems from molecular and nanoscale fine tuning of interparticle properties of molecularly linked nanoparticle assembly on flexible microelectrodes, which has important implication for the design of gauge sensors for highly sensitive detection of deformation in complex sensing environment or on complex curved surfaces such as wearable electronics and skin sensors. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Highly sensitive MoS2 photodetectors with graphene contacts

    Science.gov (United States)

    Han, Peize; St. Marie, Luke; Wang, Qing X.; Quirk, Nicholas; El Fatimy, Abdel; Ishigami, Masahiro; Barbara, Paola

    2018-05-01

    Two-dimensional materials such as graphene and transition metal dichalcogenides (TMDs) are ideal candidates to create ultra-thin electronics suitable for flexible substrates. Although optoelectronic devices based on TMDs have demonstrated remarkable performance, scalability is still a significant issue. Most devices are created using techniques that are not suitable for mass production, such as mechanical exfoliation of monolayer flakes and patterning by electron-beam lithography. Here we show that large-area MoS2 grown by chemical vapor deposition and patterned by photolithography yields highly sensitive photodetectors, with record shot-noise-limited detectivities of 8.7 × 1014 Jones in ambient condition and even higher when sealed with a protective layer. These detectivity values are higher than the highest values reported for photodetectors based on exfoliated MoS2. We study MoS2 devices with gold electrodes and graphene electrodes. The devices with graphene electrodes have a tunable band alignment and are especially attractive for scalable ultra-thin flexible optoelectronics.

  20. Conducting polymer nanofibers for high sensitivity detection of chemical analytes.

    Science.gov (United States)

    Kumar, Abhishek; Leshchiner, Ignaty; Nagarajan, Subhalakshmi; Nagarajan, Ramaswamy; Kumar, Jayant

    2008-03-01

    Possessing large surface area materials is vital for high sensitivity detection of analyte. We report a novel, inexpensive and simple technique to make high surface area sensing interfaces using electrospinning. Conducting polymers (CP) nanotubes were made by electrospinning a solution of a catalyst (ferric tosylate) along with poly (lactic acid), which is an environment friendly biodegradable polymer. Further vapor deposition polymerization of the monomer ethylenedioxy thiophene (EDOT) on the nanofiber surface yielded poly (EDOT) covered fibers. X-ray photo electron spectroscopy (XPS) study reveals the presence of PEDOT predominantly on the surface of nanofibers. Conducting nanotubes had been received by dissolving the polymer in the fiber core. By a similar technique we had covalently incorporated fluorescent dyes on the nanofiber surface. The materials obtained show promise as efficient sensing elements. UV-Vis characterization confirms the formation of PEDOT nanotubes and incorporation of chromophores on the fiber surface. The morphological characterization was carried out using scanning electron microscopy (SEM) and transmission electron microscopy (TEM).

  1. Highly Sensitive NiO Nanoparticle based Chlorine Gas Sensor

    Science.gov (United States)

    Arif, Mohd.; Sanger, Amit; Singh, Arun

    2018-03-01

    We have synthesized a chemiresistive sensor for chlorine (Cl2) gas in the range of 2-200 ppm based on nickel oxide (NiO) nanoparticles obtained by wet chemical synthesis. The nanoparticles were characterized by x-ray diffraction (XRD) analysis, field-emission scanning electron microscopy (FE-SEM), thermogravimetric analysis (TGA), transmission electron microscopy (TEM), Fourier-transform infrared (FTIR) spectroscopy, Raman spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, and photoluminescence (PL) spectroscopy. XRD spectra of the sensing layer revealed the cubic phase of NiO nanoparticles. The NiO nanoparticle size was calculated to be ˜ 21 nm using a Williamson-Hall plot. The bandgap of the NiO nanoparticles was found to be 3.13 eV using Tauc plots of the absorbance curve. Fast response time (12 s) and optimum recovery time (˜ 27 s) were observed for 10 ppm Cl2 gas at moderate temperature of 200°C. These results demonstrate the potential application of NiO nanoparticles for fabrication of highly sensitive and selective sensors for Cl2 gas.

  2. Luminescent Lanthanide Reporters for High-Sensitivity Novel Bioassays

    Energy Technology Data Exchange (ETDEWEB)

    Anstey, Mitchell R. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Fruetel, Julia A. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Foster, Michael E. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Hayden, Carl C. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Buckley, Heather L. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Arnold, John [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2013-09-01

    Biological imaging and assay technologies rely on fluorescent organic dyes as reporters for a number of interesting targets and processes. However, limitations of organic dyes such as small Stokes shifts, spectral overlap of emission signals with native biological fluorescence background, and photobleaching have all inhibited the development of highly sensitive assays. To overcome the limitations of organic dyes for bioassays, we propose to develop lanthanide-based luminescent dyes and demonstrate them for molecular reporting applications. This relatively new family of dyes was selected for their attractive spectral and chemical properties. Luminescence is imparted by the lanthanide atom and allows for relatively simple chemical structures that can be tailored to the application. The photophysical properties offer unique features such as narrow and non-overlapping emission bands, long luminescent lifetimes, and long wavelength emission, which enable significant sensitivity improvements over organic dyes through spectral and temporal gating of the luminescent signal.Growth in this field has been hindered due to the necessary advanced synthetic chemistry techniques and access to experts in biological assay development. Our strategy for the development of a new lanthanide-based fluorescent reporter system is based on chelation of the lanthanide metal center using absorbing chromophores. Our first strategy involves "Click" chemistry to develop 3-fold symmetric chelators and the other involves use of a new class of tetrapyrrole ligands called corroles. This two-pronged approach is geared towards the optimization of chromophores to enhance light output.

  3. Operationalization of the Russian Version of Highly Sensitive Person Scale

    Directory of Open Access Journals (Sweden)

    Регина Вячеславовна Ершова

    2018-12-01

    Full Text Available The aim of the present study was to operationalize a Russian version of the Highly Sensitive Person Scale (HSPS. The empirical data were collected in two ways: active, through oral advertising and inviting those who wish to take part in the study (snowball technique and passive (placement of ads about taking part in a research in social networks VKontakte and Facebook. As a result, 350 university students (117 men, 233 women, an average age of 18,2 (± 1,7 applied to a research laboratory and filled out the HSPS questionnaire, and another 510 respondents (380 women, 130 men, average age 22,6 ( ± 7,9 filled the HSPS online. The results of the study did not confirm the one-dimensional model of the construct, proposed by Aron & Aron (1997, as well as the most commonly used in the English-language studies three-factor solution. The hierarchical claster and confirmatory analyses used in the operationalization procedure allowed us to conclude that the variance of the Russian version of HSPS is best described in the framework of a two-factor model including the two separate subscales: Ease of Excitation (EOE, Low threshold of sensitivity (LTS. Sensory Processing Sensitivity may be defined as an increased susceptibility to external and internal stimuli, realized through negative emotional responses and deep susceptibility (distress to excessive stimulation.

  4. High-sensitivity active pixel sensor with variable threshold photodetector

    Science.gov (United States)

    Jo, Sung-Hyun; Bae, Myunghan; Choi, Byoung-Soo; Lyu, Hong-Kun; Shin, Jang-Kyoo

    2015-05-01

    A novel high-sensitivity active pixel sensor (APS) with a variable threshold photodetector has been presented and for the first time, a simple SPICE model for the variable threshold photodetector is presented. Its SPICE model is in good agreement with measurements and is more simpler than the conventional model. The proposed APS has a gate/body-tied PMOSFET-type photodetector with an overlapping control gate that makes it possible to control the sensitivity of the proposed APS. It is a hybrid device composed of a metal-oxide-semiconductor field-effect transistor (MOSFET), a lateral bipolar junction transistor (BJT) and a vertical BJT. Using sufficient overlapping control gate bias to operate the MOSFET in inversion mode, the variable threshold photodetector allows for increasing the photocurrent gain by 105 at low light intensities when the control gate bias is -3 V. Thus, the proposed APS with a variable threshold photodetector has better low-light-level sensitivity than the conventional APS operating mode, and it has a variable sensitivity which is determined by the control gate bias. The proposed sensor has been fabricated by using 0.35 μm 2-poly 4-metal standard complementary MOS (CMOS) process and its characteristics have been evaluated.

  5. 14 CFR 152.309 - Availability of sponsor's records.

    Science.gov (United States)

    2010-01-01

    ... the purposes of accounting and audit. (b) The sponsor or planning agency shall allow appropriate FAA... to the sponsor or planning agency. (c) It audit findings have not been resolved, the applicable... sponsor's records. (a) The sponsor or planning agency shall allow any authorized representative of the...

  6. 48 CFR 35.017-1 - Sponsoring agreements.

    Science.gov (United States)

    2010-10-01

    ... sponsoring agreement or sponsoring agencies' policies and procedures: (1) A statement of the purpose and... of the FFRDC's relationship with its sponsor(s). (3) A provision for the identification of retained earnings (reserves) and the development of a plan for their use and disposition. (4) A prohibition against...

  7. Sponsors, Sponsorship Rates and the Immigration Multiplier.

    Science.gov (United States)

    Jasso, Guillermina; Rosenzweig, Mark R.

    1989-01-01

    Reviews evidence of the extent to which U.S. immigrants utilize the family reunification entitlements of immigration laws. Examines two studies of the immigrant cohort: Jasso and Rosenzweig (1986) and the General Accounting Office report (1988). Provides estimates of the characteristics of U.S. citizen sponsors of immigrant spouses and parents.…

  8. 22 CFR 62.3 - Sponsor eligibility.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Sponsor eligibility. 62.3 Section 62.3 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES EXCHANGE VISITOR PROGRAM General Provisions... visitor program are: (1) United States local, state and federal government agencies; (2) International...

  9. Agency-Sponsored Study Abroad Programs

    Science.gov (United States)

    Frey, James S.

    1976-01-01

    Sponsors of these programs include nonprofit organizations, proprietary agencies, wholly owned subsidiaries of U.S. corporations, and foreign-based institutions catering to North American students. Problems arising from their non-accredited status are examined and a criterion instrument for evaluating them is developed. (LBH)

  10. A highly sensitive programmable OSL reader for research applications

    International Nuclear Information System (INIS)

    Ratna, P.; Gaonkar, Uma; Kulkarni, M.S.

    2012-01-01

    A highly sensitive programmable optical stimulation luminescence (OSL) reader system has been developed for research applications in the field of radiation dosimetry. The system hardware consists of stimulation source, light detection assembly, drawer assembly, high current driver for the stimulation light source, photon counting module and microcontroller card. The electronic hardware for the Reader is developed around P8952RD2BN microcontroller. Two Luxeon power LEDs (blue, 470 nm) placed diagonally opposite at 45 ° in the drawer assembly of the reader are used as a stimulation light source. The LED's together can generate a power of ∼ 100 mW/cm 2 at the sample position with a LED current of ∼ 200 mA. The reader works in constant wave-OSL (CW-OSL), light intensity modulated-OSL (LM-OSL) and nonlinear modulated OSL(NLOSL) modes of operation. The performance of the reader system is evaluated using a-Al 2 O 3 :C OSL phosphor developed in BARC. This paper discusses the study of the Reader parameters like linearity, reproducibility, sensitivity, minimum measurable dose using the Al 2 O 3 :C phosphor using CW-OSL mode. It also discusses the photoionization cross section of the Al 2 O 3 :C sample to evaluate the linearity of stimulation light intensity. The reader also has a facility to measure the LED light intensity at the sample position. The LM-OSL curves are plotted photoionization cross-section of various phosphor materials was evaluated. Such low cost reader systems are very useful for radiation dosimetry and material research. (author)

  11. A highly sensitive programmable OSL reader for research applications

    International Nuclear Information System (INIS)

    Ratna, P.; Gaonkar, Uma; Kulkarni, M.S.

    2012-01-01

    A Highly sensitive programmable Optical Stimulation Luminescence (OSL) reader system has been developed for Research applications in the field of radiation dosimetry. The system hardware consists of stimulation source, light detection assembly, drawer assembly, high current driver for the stimulation light source, photon counting module and microcontroller card. The electronic hardware for the Reader is developed around P8952RD2BN microcontroller. Two Luxeon power LEDs (blue, 470 nm) placed diagonally opposite at 45 deg. in the drawer assembly of the reader are used as a stimulation light source. The LEDs together can generate a power of ∼ 100 mW/cm 2 at the sample position with a LED current of ∼ 200 mA. The reader works in constant wave-OSL (CW-OSL), light intensity modulated-OSL (LM-OSL) and non linear modulated OSL (NLOSL) modes. The performance of the reader system is evaluated using a-Al 2 O 3 :C OSL phosphor developed in BARC. This paper discusses the study of the Reader parameters like linearity, reproducibility, sensitivity, minimum measurable dose of the reader for the Al 2 O 3 :C phosphor samples using CW-OSL mode. It also discusses the photoionization cross section of the Al 2 O 3 :C sample to evaluate the linearity of stimulation light intensity. For the verification of the LM-OSL mode, OSL curves are plotted and shown that how the glow peaks are shifting towards left with respect to the time scale as the stimulation light intensity increases on the sample for the same radiation exposure. It is also shown that if the ramp rate of power is constant, the LM-OSL peak height increases with respect to the increase in the exposures. This reader also gives the facility to measure the LED current and intensity at the sample position and feeds value to the PC along with the readings. (author)

  12. Highly sensitive and selective colorimetric sensing of antibiotics in milk.

    Science.gov (United States)

    Zhang, Xiaofang; Zhang, Yang; Zhao, Hong; He, Yujian; Li, Xiangjun; Yuan, Zhuobin

    2013-05-17

    Antibiotics residues in foods are very harmful to human beings. Determination of antibiotics residues relies largely on the availability of adequate analytical techniques. Currently, there is an urgent need for on site and real time detection of antibiotics in food. In this work, a novel one step synthesis of gold nanoparticles (AuNPs) was proposed using pyrocatechol violet (PCV) as a reducer agent. Highly sensitive and selective colorimetric detection of four antibiotics kanamycin mono sulfate (KA), neomycin sulfate (NE), streptomycin sulfate (ST) and bleomycin sulfate (BL) was realized during the formation of AuNPs. PCV has -OH groups and these antibiotics have -OH, -NH2, -NH- groups, so there may be some special hydrogen-bonding interactions between PCV and these antibiotics. Therefore, the presence of KA, NE, ST and BL would influence the synthesis of AuNPs, then the color and state of AuNPs would change, which could be observed with the naked eye or a UV-vis spectrophotometer. Results showed that A670 was linear with the logarithm of KA concentration in the range from 1.0×10(-8) to 5.0×10(-7)M and 5.0×10(-7) to 5.5×10(-5)M. The detection limit of KA was 1.0×10(-9)M (S/N=3). The coexisting substances including 1.0×10(-5)M phenylalanine, alanine, glycerol, glucose, Mg(2+), Ca(2+), Na(+), K(+), CO3(2-), SO4(2-), NO3(-), Cl(-) and Br(-) did not affect the determination of 1.0×10(-7)M antibiotics. In particular, the proposed method could be applied successfully to the detection of antibiotics in the pretreated liquid milk products. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. High-sensitivity Cardiac Troponin Elevation after Electroconvulsive Therapy (ECT)

    Science.gov (United States)

    Duma, Andreas; Pal, Swatilika; Johnston, Joshua; Helwani, Mohammad A.; Bhat, Adithya; Gill, Bali; Rosenkvist, Jessica; Cartmill, Christopher; Brown, Frank; Miller, J. Philip; Scott, Mitchell G; Sanchez-Conde, Francisco; Jarvis, Michael; Farber, Nuri B.; Zorumski, Charles F.; Conway, Charles; Nagele, Peter

    2017-01-01

    Background While electroconvulsive therapy (ECT) is widely regarded as a life-saving and safe procedure, evidence regarding its effects on myocardial cell injury are sparse. The objective of this investigation was to determine incidence and magnitude of new cardiac troponin elevation after ECT using a novel high-sensitivity cardiac troponin I (hscTnI) assay. Methods This was a prospective cohort study in adult patients undergoing ECT in a single academic center (up to three ECT treatments per patient). The primary outcome was new hscTnI elevation after ECT, defined as an increase of hscTnI >100% after ECT compared to baseline with at least one value above the limit of quantification (10 ng/L). 12-lead ECG and hscTnI values were obtained prior to and 15–30 minutes after ECT; in a subset of patients an additional 2-hour hscTnI value was obtained. Results The final study population was 100 patients and a total of 245 ECT treatment sessions. Eight patients (8/100, 8%) experienced new hscTnI elevation after ECT with a cumulative incidence of 3.7% (9/245 treatments; one patient had two hscTnI elevations), two of whom had a non-ST-elevation myocardial infarction (incidence 2/245, 0.8%). Median hscTnI concentrations did not increase significantly after ECT. Tachycardia and/or elevated systolic blood pressure developed after approximately two thirds of ECT treatments. Conclusions ECT appears safe from a cardiac standpoint in a large majority of patients. A small subset of patients with pre-existing cardiovascular risk factors, however, may develop new cardiac troponin elevation after ECT, the clinical relevance of which is unclear in the absence of signs of myocardial ischemia. PMID:28166110

  14. CERN: an aerial view

    CERN Document Server

    2004-01-01

    On 30th January, when CERN still resembled a winter wonderland, a helicopter with a photographer on board took off on an aerial tour. One sunny morning at the end of January, when the area was waking up to an overnight snowfall, a helicopter took off from the Meyrin site with a CERN photographer on board. CERN has been the subject of aerial photographs ever since its creation. Although its appearance has changed over the years, the Laboratory has aged well. The aerial photographs taken during its fifty-year history bear witness to its expansion, showing how a handful of buildings and a first accelerator have blossomed into an entire machine complex. Let's take to the skies and have a look at some of the photos taken on this crisp January morning: a sight for sore eyes! In the foreground, Building 40 on the Meyrin site is recognisable from its magnet shape.On the right of the Route de Meyrin (crossing the photo diagonally), next to Point 1, the work on the Globe of Innovation, which got underway at the beg...

  15. Adaptive unmanned aerial vechile control

    OpenAIRE

    Bernotaitis, Vilimantas

    2016-01-01

    This thesis analyzes unmanned aerial vehicles and its adaptivity - their structures, operational principles and components. Also analyzing algorithms of adaptive neural networks and their usage in unmanned aerial vehicles. The main objective of this thesis is to analyze structures, control systems of unmanned aerial vehicles and their abilities to adapt to changing environment. This thesis contains analysis of already used solutions and their drawbacks. As research made in this thesis shown t...

  16. The Complex Dynamics of Sponsored Search Markets

    Science.gov (United States)

    Robu, Valentin; La Poutré, Han; Bohte, Sander

    This paper provides a comprehensive study of the structure and dynamics of online advertising markets, mostly based on techniques from the emergent discipline of complex systems analysis. First, we look at how the display rank of a URL link influences its click frequency, for both sponsored search and organic search. Second, we study the market structure that emerges from these queries, especially the market share distribution of different advertisers. We show that the sponsored search market is highly concentrated, with less than 5% of all advertisers receiving over 2/3 of the clicks in the market. Furthermore, we show that both the number of ad impressions and the number of clicks follow power law distributions of approximately the same coefficient. However, we find this result does not hold when studying the same distribution of clicks per rank position, which shows considerable variance, most likely due to the way advertisers divide their budget on different keywords. Finally, we turn our attention to how such sponsored search data could be used to provide decision support tools for bidding for combinations of keywords. We provide a method to visualize keywords of interest in graphical form, as well as a method to partition these graphs to obtain desirable subsets of search terms.

  17. Aerial in situ survey

    International Nuclear Information System (INIS)

    Cespirova, I.

    2004-01-01

    In 2001 a detailed exploration of soil contamination took place in the mountainous region Hruby Jesenik located in northeastern part of the Czech Republic. This region was selected for the higher contamination of 137 Cs after Chernobyl accident. For monitoring of an area about 100km 2 aerial monitoring system IRIS (located on board of helicopter MI-17) was used. The parameters of measurement were: flight height above ground 80 m, speed 100 km/h, distance of flight lines 250 m, intervals of spectra recording 1s. For more detailed exploration of ground contamination in this area complementary ground-based mobile group measurements were performed. (author)

  18. DOE-EERC jointly sponsored research program

    Energy Technology Data Exchange (ETDEWEB)

    Hendrikson, J.G.; Sondreal, E.A.

    1999-09-01

    U.S. Department of Energy (DOE) Cooperative Agreement DE-FC21-93MC30098 funded through the Office of Fossil Energy and administered at the Federal Energy Technology Center (FETC) supported the performance of a Jointly Sponsored Research Program (JSRP) at the Energy and Environmental Research Center (EERC) with a minimum 50% nonfederal cost share to assist industry in commercializing and effectively applying efficient, nonpolluting energy technologies that can compete effectively in meeting market demands for clean fuels, chemical feedstocks, and electricity in the 21st century. The objective of the JSRP was to advance the deployment of advanced technologies for improving energy efficiency and environmental performance through jointly sponsored research on topics that would not be adequately addressed by the private sector alone. Examples of such topics include the barriers to hot-gas cleaning impeding the deployment of high-efficiency power systems and the search for practical means for sequestering CO{sub 2} generated by fossil fuel combustion. The selection of particular research projects was guided by a combination of DOE priorities and market needs, as provided by the requirement for joint venture funding approved both by DOE and the private sector sponsor. The research addressed many different energy resource and related environmental problems, with emphasis directed toward the EERC's historic lead mission in low-rank coals (LRCs), which represent approximately half of the U.S. coal resources in the conterminous states, much larger potential resources in Alaska, and a major part of the energy base in the former U.S.S.R., East Central Europe, and the Pacific Rim. The Base and JSRP agreements were tailored to the growing awareness of critical environmental issues, including water supply and quality, air toxics (e.g., mercury), fine respirable particulate matter (PM{sub 2.5}), and the goal of zero net CO{sub 2} emissions.

  19. 45 CFR 233.51 - Eligibility of sponsored aliens.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Eligibility of sponsored aliens. 233.51 Section... CONDITIONS OF ELIGIBILITY IN FINANCIAL ASSISTANCE PROGRAMS § 233.51 Eligibility of sponsored aliens... affidavit(s) of support or similar agreement on behalf of an alien (who is not the child of the sponsor or...

  20. 14 CFR 151.121 - Procedures: Offer; sponsor assurances.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Procedures: Offer; sponsor assurances. 151.121 Section 151.121 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Engineering Proposals § 151.121 Procedures: Offer; sponsor assurances. Each sponsor must adopt the following...

  1. 17 CFR 229.1104 - (Item 1104) Sponsors.

    Science.gov (United States)

    2010-04-01

    .... (c) Describe the sponsor's securitization program and state how long the sponsor has been engaged in the securitization of assets. The description must include, to the extent material, a general... material roles and responsibilities in its securitization program, including whether the sponsor or an...

  2. Aerial measuring systems program

    International Nuclear Information System (INIS)

    Jobst, J.E.

    1979-01-01

    EG and G, Inc., has developed for the Department of Energy (DOE) an Aerial Measuring Systems (AMS) program dedicated to environmental research at facilities of interest to DOE, the Nuclear Regulatory Commission (NRC), and other federal agencies. The AMS was orginally created to measure nuclear radiation; the program scope has been broadened dramatically to include a wide variety of remote sensors: multispectral and mapping cameras, optical and infrared multispectral scanners, air-sampling systems, and meteorological sensors. The AMS maintains seven aircraft as survey platforms, both fixed-wind aircraft and helicopters. Photography, scanner imagery, and radiation data are processed in dedicated, modern laboratories and used for a broad range of environmental impact studies. A graphic overview system has been developed for effective presentation of all types of remotely sensed data obtained at a facility of interest

  3. Morphing unmanned aerial vehicles

    International Nuclear Information System (INIS)

    Gomez, Juan Carlos; Garcia, Ephrahim

    2011-01-01

    Research on aircraft morphing has exploded in recent years. The motivation and driving force behind this has been to find new and novel ways to increase the capabilities of aircraft. Materials advancements have helped to increase possibilities with respect to actuation and, hence, a diversity of concepts and unimagined capabilities. The expanded role of unmanned aerial vehicles (UAVs) has provided an ideal platform for exploring these emergent morphing concepts since at this scale a greater amount of risk can be taken, as well as having more manageable fabrication and cost requirements. This review focuses on presenting the role UAVs have in morphing research by giving an overview of the UAV morphing concepts, designs, and technologies described in the literature. A presentation of quantitative information as well as a discussion of technical issues is given where possible to begin gaining some insight into the overall assessment and performance of these technologies. (topical review)

  4. What can Bilfinger teach Olympic sponsors?

    Directory of Open Access Journals (Sweden)

    Mark Dodds

    2016-10-01

    Full Text Available Bilfinger SE (Bilfinger is a leading international engineering and services group (Bilfinger.com, 2015, and was a local sponsor of the 2014 FIFA World Cup. The company is accused of paying bribes through its subsidiary company, Mauell, (dw. com, 2015 to public officials in Brazil for contracts related to the 2014 World Cup (Cassin, 2015. The corruption allegations relate to orders to equip security command centers at twelve host cities during the 2014 World Cup in Brazil (dw.com, 2015. Because Brazil hosted the 2014 FIFA World Cup and will host the 2016 Summer Olympic Games, companies need to consider the risks of many international anti-corruption laws, such as Brazil’s anti-corruption law commonly referred as The Clean Companies Act and other applicable anticorruption law like the United States’ Foreign Corrupt Practices Act (Rogers, et. al, 2014. This paper will analyze the Bilfinger case involving corruption activity at the 2014 FIFA World Cup and offer insights for sponsors of the 2016 Summer Olympic Games.

  5. Aerial measuring system in Japan.

    Science.gov (United States)

    Lyons, Craig; Colton, David

    2012-05-01

    The U.S. Department of Energy/National Nuclear Security Administration's (DOE/NNSA) Aerial Measuring System (AMS) deployed personnel and equipment to partner with the U.S. Forces in Japan (USFJ) to conduct multiple aerial radiological surveys. These were the first and most comprehensive sources of actionable information for U.S. interests in Japan and provided early confirmation to the Government of Japan as to the extent of the release from the Fukushima Daiichi Nuclear Power Plant. Many challenges were overcome quickly during the first 48 h, including installation and operation of Aerial Measuring System equipment on multiple USFJ aircraft, flying over difficult terrain, and flying with USFJ pilots who were unfamiliar with the Aerial Measuring System flight patterns. These factors combined to make for a programmatically unanticipated situation. In addition to the challenges of multiple and ongoing releases, integration with the Japanese government to provide valid aerial radiological survey products that both military and civilian customers could use to make informed decisions was extremely complicated. The Aerial Measuring System Fukushima response provided insight into addressing these challenges and gave way to an opportunity for the expansion of the Aerial Measuring System's mission beyond the borders of the U.S.

  6. European multicenter analytical evaluation of the Abbott ARCHITECT STAT high sensitive troponin I immunoassay

    DEFF Research Database (Denmark)

    Krintus, Magdalena; Kozinski, Marek; Boudry, Pascal

    2014-01-01

    high sensitive cardiac troponin I (hs-cTnI) assay and its 99th percentile upper reference limit (URL). METHODS: Laboratories from nine European countries evaluated the ARCHITECT STAT high sensitive troponin I (hs-TnI) immunoassay on the ARCHITECT i2000SR/i1000SR immunoanalyzers. Imprecision, limit...

  7. Academic investigator-initiated trials and the challenge of sponsor responsibility: the Cologne Sponsor Model.

    Science.gov (United States)

    Georgias, Christine; Grunow, Andrea; Olderog, Miriam; May, Alexander; Paulus, Ursula

    2012-12-01

    With the amendment to the German Drug Law in 2004, the conduct of clinical trials changed by at least two main aspects: (1) The principles of Good Clinical Practice (GCP) were implemented in the national legislation, and (2) for the first time, the function of the sponsor of a clinical trial and the clinical trial itself have become legally binding definitions. By that, legal differences between industrial and academic clinical trials no longer exist. Clinical trials initiated by investigators have to fulfil the same requirements while the entire sponsor responsibility has to be carried out by the Coordinating Investigator or his institution including implementation of a quality management system according to the GCP. The Cologne Sponsor Model is an effective approach with settings, structures, basic features, action, and reporting lines, as well as funding for clinical trials initiated in an academic environment. The University of Cologne assumes the sponsor responsibility for clinical trials organised by the university researchers according to law. Sponsor's duties are delegated to a central operational unit of the sponsor - the Clinical Trials Center Cologne - which further delegates duties to the Coordinating Investigator. Clinical Trials Center Cologne was established in 2002 to support the performance of clinical trials at the university by offering comprehensive advisory and practical services covering all aspects of study planning and conduct. Furthermore, a specialised division of its quality management department acts as an independent sponsor's Quality Assurance Unit. The Clinical Trials Center Cologne has established a quality management system consisting of different components (1) to enable a reasoned decision to subsequent delegation, (2) for risk-based surveillance of trial conduct (audits, monitoring-checks, and reports), and (3) support and training of the Coordinating Investigator. Double functions of persons and departments in the university

  8. Aerial measurements in Finland

    Energy Technology Data Exchange (ETDEWEB)

    Winkelmann, I.; Thomas, M.; Buchroeder, H.; Brummer, C. [Federal Office for Radiation Protection, Berlin (Germany); Carloff, G. [German Federal Border Police, Grenzschutz-Fliegergruppe, Sankt Augustin (Germany)

    1997-12-31

    Aerial measurements were performed to determine the {sup 137}Cs soil contamination in a given region to detect unknown radiation sources and to assess their activity. For these measurements a computerized gamma ray spectrometer, equipped with a high purity Ge-semiconductor detector and a 12 l volume Nal(Tl)-detector was used. HPGe-detector measurements from different altitudes over area I were done to test and re-calibrate the aerial measuring system. The known {sup 137}Cs contamination of (50.7 {+-} 5.2) kBq m{sup -2} could be confirmed by the measured value of (57 {+-} 10) kBq m{sup -2}. the Nal(Tl)-detector was re-calibrated at that site for further {sup 137}Cs measurements over area II. The area II was surveyed from an altitude of about 70 m and at a parallel line distance of 150 m at an flying speed of 100 km h{sup -1} to determine the {sup 137}Cs soil contamination. The measuring time was two seconds for the Nal(Tl)-detector. For the spectra measured with the HPGe-detector, a measuring time of 30 s each was chosen. From the Nal(Tl)-measurements, a mean {sup 137}Cs value of (60 {+-} 20) kBq m{sup -2} was determined with a maximum value of 90 kBq m{sup -2}. The corresponding values measured by HPGe-detector were (70 {+-} 20) kBq m{sup -2} and 120 kBq m{sup -2}, respectively. For the evaluation of the HPGe-spectra a depth distribution parameter {alpha}/{rho} = (0.44 {+-} 0.21) cm{sup 2} g{sup -1} for {sup 137}Cs was used measured from soil samples. From data measured with the Nal(Tl)-detector during flights over area III, three{sup 60}Co-sources and one {sup 137}Cs source could be detected, localized and their activity assessed. By HPGe-detector measurements, only scattered {sup 192}lr radiation was registered. (au).

  9. Jointly Sponsored Research Program Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    Western Research Institute

    2009-03-31

    Cooperative Agreement, DE-FC26-98FT40323, Jointly Sponsored Research (JSR) Program at Western Research Institute (WRI) began in 1998. Over the course of the Program, a total of seventy-seven tasks were proposed utilizing a total of $23,202,579 in USDOE funds. Against this funding, cosponsors committed $26,557,649 in private funds to produce a program valued at $49,760,228. The goal of the Jointly Sponsored Research Program was to develop or assist in the development of innovative technology solutions that will: (1) Increase the production of United States energy resources - coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. Under the JSR Program, energy-related tasks emphasized enhanced oil recovery, heavy oil upgrading and characterization, coal beneficiation and upgrading, coal combustion systems development including oxy-combustion, emissions monitoring and abatement, coal gasification technologies including gas clean-up and conditioning, hydrogen and liquid fuels production, coal-bed methane recovery, and the development of technologies for the utilization of renewable energy resources. Environmental-related activities emphasized cleaning contaminated soils and waters, processing of oily wastes, mitigating acid mine drainage, and demonstrating uses for solid waste from clean coal technologies, and other advanced coal-based systems. Technology enhancement activities included resource characterization studies, development of improved methods, monitors and sensors. In general the goals of the tasks proposed were to enhance competitiveness of U.S. technology, increase production of domestic resources, and reduce environmental

  10. Droning On: American Strategic Myopia Toward Unmanned Aerial Systems

    Science.gov (United States)

    2013-12-01

    UAS unmanned aerial system UAV unmanned aerial vehicle UCAV unmanned combat aerial vehicle WASP wireless aerial surveillance platform WMD weapons of...remotely piloted vehicles (RPV), unmanned aerial vehicles (UAV), unmanned combat aerial vehicle ( UCAV ), unmanned aerial systems (UAS), or more

  11. List of Organizing Committees and Sponsors

    Science.gov (United States)

    2012-03-01

    Organizers DIRECTORS Maria L CalvoPresident of International Commission for Optics, Spain Aram V PapoyanDirector of Institute for Physical Research of NAS, Armenia HEADS OF PROJECT Tigran Dadalyan YSU, Armenia Artsrun MartirosyanIPR, Armenia COORDINATOR Narine GevorgyanIPR, Armenia / ICTP, Italy MANAGERS Paytsar MantashyanIPR, Armenia Karen VardanyanIPR, Armenia INTERNATIONAL ADVISORY COMMITTEE Marcis AuzinshLatvia Roland AvagyanArmenia Tapash ChakrabortyCanada Yuri ChilingaryanArmenia Eduard KazaryanArmenia Albert KirakosyanArmenia Radik KostanyanArmenia Avinash PandeyIndia Marat SoskinUkraine INTERNATIONAL PROGRAM COMMITTEE David Sarkisyan (Chair)Armenia Roman AlaverdyanArmenia Dan ApostolRomania Levon AslanyanArmenia Aranya BhattacherjeeIndia Gagik BuniatyanArmenia Vigen ChaltykyanArmenia Roldao Da RochaBrazil Miltcho DanailovItaly Vladimir GerdtRussia Samvel GevorgyanArmenia Gayane GrigoryanArmenia Rafik HakobyanArmenia Takayuki MiyaderaJapan Levon MouradianArmenia Atom MuradyanArmenia Simon RochesterUSA Hayk SarkisyanArmenia Aleksandr VardanyanArmenia LOCAL ORGANIZING COMMITTEE Narek AghekyanArmenia Anahit GogyanArmenia Melanya GrigoryanArmenia Armen HovhannisyanArmenia Lilit HovhannisyanArmenia Tatevik KhachatryanArmenia Astghik KuzanyanArmenia Satenik KuzanyanArmenia Vladimir LazarevRussia Lilit MantashyanArmenia Hripsime MkrtchyanArmenia Pavel MuzhikyanArmenia Wahi NarsisianArmenia Sahak OrdukhanyanArmenia Anna ReymersArmenia Narine TorosyanArmenia The Symposium was organized by YSU & NAS SPIE Armenian Student Chapter Institute for Physical Research (IPR) of National Academy of Sciences (NAS) Russian-Armenian (Slavonic) University (RAU) LT-PYRKAL cjsc Yerevan State University (YSU) Official Sponsors of the Symposium LT-PYRKAlRussian ArmenianSPIE LT-PYRKAL cjscRussian-Armenian UniversityYSU & NAS SPIE Student Chapter Further sponsors NFSATICTPSCSADevout Generation National Foundation of Science and Advanced TechnologiesThe Abdus Salam International Centre

  12. Jointly Sponsored Research Program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    The Jointly Sponsored Research Program (JSRP) is a US Department of Energy (DOE) program funded through the Office of Fossil Energy and administered at the Morgantown Energy Technology Center. Under this program, which has been in place since Fiscal Year 1990, DOE makes approximately $2.5 million available each year to the Energy and Environmental Research Center (EERC) to fund projects that are of current interest to industry but which still involve significant risk, thus requiring some government contribution to offset the risk if the research is to move forward. The program guidelines require that at least 50% of the project funds originate from nonfederal sources. Projects funded under the JSRP often originate under a complementary base program, which funds higher-risk projects. The projects funded in Fiscal Year 1996 addressed a wide range of Fossil Energy interests, including hot-gas filters for advanced power systems; development of cleaner, more efficient processing technologies; development of environmental control technologies; development of environmental remediation and reuse technologies; development of improved analytical techniques; and development of a beneficiation technique to broaden the use of high-sulfur coal. Descriptions and status for each of the projects funded during the past fiscal year are included in Section A of this document, Statement of Technical Progress.

  13. High Sensitivity Semiconductor Sensor Skins for Multi-Axis Surface Pressure Characterization, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — This NASA Phase II SBIR program would fabricate high sensitivity semiconductor nanomembrane 'sensor skins' capable of multi-axis surface pressure characterization on...

  14. High Sensitivity, High Frequency Sensors for Hypervelocity Testing and Analysis, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — This NASA Phase II SBIR program would develop high sensitivity, high frequency nanomembrane based surface sensors for hypervelocity testing and analysis on wind...

  15. High Sensitivity Semiconductor Sensor Skins for Multi-Axis Surface Pressure Characterization, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This NASA Phase I SBIR program would fabricate high sensitivity semiconductor nanomembrane 'sensor skins' capable of multi-axis surface pressure characterization on...

  16. High Sensitivity Indium Phosphide Based Avalanche Photodiode Focal Plane Arrays, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — nLight has demonstrated highly-uniform APD arrays based on the highly sensitive InGaAs/InP material system. These results provide great promise for achieving the...

  17. High Sensitivity, High Frequency Sensors for Hypervelocity Testing and Analysis, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This NASA Phase I SBIR program would develop high sensitivity, high frequency nanomembrane (NM) based surface sensors for hypervelocity testing and analysis on wind...

  18. Portable High Sensitivity and High Resolution Sensor to Determine Oxygen Purity Levels, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this Phase I STTR project is to develop a highly sensitive oxygen (O2) sensor, with high accuracy and precision, to determine purity levels of high...

  19. Diagnostic performance of high-sensitive troponin T in patients with renal insufficiency.

    Science.gov (United States)

    Pfortmueller, Carmen A; Funk, Georg-Christian; Marti, Grischa; Leichtle, Alexander B; Fiedler, Georg M; Schwarz, Christoph; Exadaktylos, Aristomenis K; Lindner, Gregor

    2013-12-15

    In the present study, we wanted to (1) evaluate whether high-sensitive troponin T levels correlate with the grade of renal insufficiency and (2) test the accuracy of high-sensitive troponin T determination in patients with renal insufficiency for diagnosis of acute myocardial infarction (AMI). In this cross-sectional analysis, all patients who received serial measurements of high-sensitive troponin T from August 1, 2010, to October 31, 2012, at the Department of Emergency Medicine were included. We analyzed data on baseline characteristics, reason for referral, medication, cardiovascular risk factors, and outcome in terms of presence of AMI along with laboratory data (high-sensitive troponin T, creatinine). A total of 1,514 patients (67% male, aged 65 ± 16 years) were included, of which 382 patients (25%) had moderate to severe renal insufficiency and significantly higher levels of high-sensitive troponin T on admission (0.028 vs 0.009, p Renal Disease estimated glomerular filtration rate >60 ml/min presenting with acute chest pain or dyspnea and 0.535 (SE 0.056) for patients with moderate to severe renal insufficiency presenting with acute chest pain or dyspnea. In conclusion, the diagnostic accuracy for presence of AMI of a baseline measurement of high-sensitive troponin in patients with renal insufficiency was poor and resembles tossing a coin. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. Team sponsors in community-based health leadership programs.

    Science.gov (United States)

    Patterson, Tracy Enright; Dinkin, Donna R; Champion, Heather

    2017-05-02

    Purpose The purpose of this article is to share the lessons learned about the role of team sponsors in action-learning teams as part of community-based health leadership development programs. Design/methodology/approach This case study uses program survey results from fellow participants, action learning coaches and team sponsors to understand the value of sponsors to the teams, the roles they most often filled and the challenges they faced as team sponsors. Findings The extent to which the sponsors were perceived as having contributed to the work of the action learning teams varied greatly from team to team. Most sponsors agreed that they were well informed about their role. The roles sponsors most frequently played were to provide the teams with input and support, serve as a liaison to the community and serve as a sounding board, motivator and cheerleader. The most common challenges or barriers team sponsors faced in this role were keeping engaged in the process, adjusting to the role and feeling disconnected from the program. Practical implications This work provides insights for program developers and community foundations who are interested in building the capacity for health leadership by linking community sponsors with emerging leaders engaged in an action learning experience. Originality/value This work begins to fill a gap in the literature. The role of team sponsors has been studied for single organization work teams but there is a void of understanding about the role of sponsors with multi-organizational teams working to improve health while also learning about leadership.

  1. 1944 AAF 661 Aerial Photo Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial photographs are retrievable on a frame by frame basis. The aerial photo inventory contains imagery from various sources that are now archived at the Earth...

  2. 1943 AAF 332 Aerial Photo Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial photographs are retrievable on a frame by frame basis. The aerial photo inventory contains imagery from various sources that are now archived at the Earth...

  3. 1946 Penasco DDQ Aerial Photo Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial photographs are retrievable on a frame by frame basis. The aerial photo inventory contains imagery from various sources that are now archived at the Earth...

  4. 1949 Lea County DHO Aerial Photo Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial photographs are retrievable on a frame by frame basis. The aerial photo inventory contains imagery from various sources that are now archived at the Earth...

  5. 1946 Eddy County DEO Aerial Photo Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial photographs are retrievable on a frame by frame basis. The aerial photo inventory contains imagery from various sources that are now archived at the Earth...

  6. 42 CFR 423.401 - General requirements for PDP sponsors.

    Science.gov (United States)

    2010-10-01

    ... sponsor is organized and licensed under State law as a risk bearing entity eligible to offer health insurance or health benefits coverage in each State in which it offers a prescription drug plan. If not... with State Law and Preemption by Federal Law § 423.401 General requirements for PDP sponsors. (a...

  7. 14 CFR 152.103 - Sponsors: Airport development.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Sponsors: Airport development. 152.103 Section 152.103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Sponsors: Airport development. (a) To be eligible to apply for a project for airport development with...

  8. 76 FR 2807 - New Animal Drugs; Change of Sponsor

    Science.gov (United States)

    2011-01-18

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 510 New Animal Drugs; Change of Sponsor AGENCY...) is amending the animal drug regulations to reflect a change of sponsor for hemoglobin glutamer-200... ownership of, and all rights and interest in, NADA 141-067 for OXYGLOBIN (hemoglobin glutamer-200) to OPK...

  9. The relationship between absenteeism and employer-sponsored ...

    African Journals Online (AJOL)

    6This article makes a specific contribution to studies on the use of on-site employer-sponsored ... 7Key words: absenteeism, child care, types of absenteeism, family-friendly practices, employer-sponsored child care ...... models to study the absence-taking process', Journal of Applied Psychology, 74: 300–316. Harrison, D.A. ...

  10. Sponsors of Nebraska Indochinese Refugees: Meeting the Challenges.

    Science.gov (United States)

    Meredith, William H.; Cramer, Sheran L.

    This report summarizes the response of 80 sponsors of Indochinese refugees in Nebraska to a survey designed to explore their sponsorship experience. Problem solving areas for sponsors and refugees are named as: acculturation, emotional adjustments, communication, health, housing, transportation, employment, and legal, financial and consumer…

  11. Aerial Refueling Clearance Initiation Request

    Science.gov (United States)

    2016-07-14

    determined the material does not contain any classified, controlled unclassified, export controlled, trademarked Qr proprietary information and detennined... Manager __________ [Signed] _________ __________ [Signed] _________ David A Benson, AFLCMC/EZFA Chairman, Joint Standardization Board (JSB) for Aerial...the direct guidance and support of ARSAG leadership and with the focused efforts of ARSAG team members. Keith Hewitt provided support for the

  12. A Flexible and Highly Sensitive Piezoresistive Pressure Sensor Based on Micropatterned Films Coated with Carbon Nanotubes

    Directory of Open Access Journals (Sweden)

    Jia-lin Yao

    2016-01-01

    Full Text Available Excellent flexibility, high sensitivity, and low consumption are essential characteristics in flexible microtube pressure sensing occasion, for example, implantable medical devices, industrial pipeline, and microfluidic chip. This paper reports a flexible, highly sensitive, and ultrathin piezoresistive pressure sensor for fluid pressure sensing, whose sensing element is micropatterned films with conductive carbon nanotube layer. The flexible pressure sensor, the thickness of which is 40 ± 10 μm, could be economically fabricated by using biocompatible polydimethylsiloxane (PDMS. Experimental results show that the flexible pressure sensor has high sensitivity (0.047 kPa−1 in gas sensing and 5.6 × 10−3 kPa−1 in liquid sensing and low consumption (<180 μW, and the sensor could be used to measure the pressure in curved microtubes.

  13. A buried intrusion monitoring system based on high sensitivity optical fiber geophone

    Science.gov (United States)

    Li, Shujuan; Zhang, Faxiang; Zhang, Xiaolei; Sun, Zhihui; Min, Li; Wang, Chang

    2017-10-01

    A new intrusion monitoring system is designed, based on a high sensitivity fiber grating geophone and PGC interferometric demodulation. A kind of high sensitive fiber Bragg grating geophone is designed. The sensitivity of the geophone is analyzed by finite element software. The PGC interferometric demodulation algorithm is used to detect the wavelength of the geophone, to reduce the noise of the system and improve the signal-to-noise ratio. Invasive monitoring test was carried out, the personnel and vehicles invading signal were collected and analyzed. Test results show that the intrusion monitoring system based on fiber geophone can effectively identify remote intrusion, and has low false alarm rate.

  14. Serine Protease Zymography: Low-Cost, Rapid, and Highly Sensitive RAMA Casein Zymography.

    Science.gov (United States)

    Yasumitsu, Hidetaro

    2017-01-01

    To detect serine protease activity by zymography, casein and CBB stain have been used as a substrate and a detection procedure, respectively. Casein zymography has been using substrate concentration at 1 mg/mL and employing conventional CBB stain. Although ordinary casein zymography provides reproducible results, it has several disadvantages including time-consuming and relative low sensitivity. Improved casein zymography, RAMA casein zymography, is rapid and highly sensitive. RAMA casein zymography completes the detection process within 1 h after incubation and increases the sensitivity at least by tenfold. In addition to serine protease, the method also detects metalloprotease 7 (MMP7, Matrilysin) with high sensitivity.

  15. Aerial Visual Shape Discrimination and Matching-To-Sample Problem Solving Ability of an Atlantic Bottlenose Dolphin.

    Science.gov (United States)

    1978-05-01

    MD-l69 356 AERIAL VISUL SHAPE DISCRIINATION AND / MATCHING-TO-SANPLE PROBLEM SOLVINO.. (U) NAVAL OCEAN SYSTEMS CENTER SAN DIEGO CA N K CHUN MAY 76...ADMINISTRATIVE INFORMATION ’A The research was conducted at the Naval Ocean Systems (enter. Hawaii Laboratory,. and sponsored by Naval Sea Systems Command...reduce well to quantification, and are governed by theories of Gestalt psychology. In applying information theory to the measurement of form parameters

  16. Alternatives to retaliation in response to state sponsored terrorist attacks

    OpenAIRE

    Evans, Paul James

    2014-01-01

    Approved for public release; distribution is unlimited We consider a game played between a state sponsor of international terrorism, a terrorist organization and the victim of a terrorist attack. The state sponsor wishes to inflict as much damage to the victim as possible without risking retaliation. The victim state wishes to end these attacks as soon as possible, through non-retaliatory means if possible in order to avoid the penalty associated with retaliation. In this thesis we compare...

  17. Highly sensitive biosensing based on interference from light scattering in capillary tubes

    DEFF Research Database (Denmark)

    Sørensen, H.S.; Larsen, N.B.; Latham, J.C.

    2006-01-01

    with the affinity layer on the fused silica capillary. Within the framework of the model it is of paramount importance to establish a valid stop criterion for the infinite summations involved in the fringe pattern computations. The high sensitivity towards surface changes, ease of changing the surface chemistry...

  18. Highly sensitive optical chemosensor for the detection of Cu 2 using ...

    Indian Academy of Sciences (India)

    Highly sensitive colorimetric chemosensor molecule RHN for selective detection of Cu2+ in mixed CH3CN aqueous media was designed and prepared by incorporating the well-known rhodamine fluorophore and a terdentate O2N binding unit into one molecule. The chemosensor RHN showed not only a reversible, ...

  19. Depleted Nanocrystal-Oxide Heterojunctions for High-Sensitivity Infrared Detection

    Science.gov (United States)

    2015-08-28

    of Computer Science and Electrical Engineering, Morgantown, West Virginia 26506, United States Abstract. CdSe-based nanocrystal quantum wells (QWs...Approved for Public Release; Distribution Unlimited Final Report: 4.3 Electronic Sensing - Depleted Nanocrystal - Oxide Heterojunctions for High...reviewed journals: Final Report: 4.3 Electronic Sensing - Depleted Nanocrystal -Oxide Heterojunctions for High-Sensitivity Infrared Detection Report Title

  20. High-sensitivity cardiac troponin T predicts mortality after hospitalization for community-acquired pneumonia

    NARCIS (Netherlands)

    Vestjens, Stefan M T; Spoorenberg, Simone M C; Rijkers, Ger T.; Grutters, Jan C; ten Berg, Jurriën M; Noordzij, Peter G.; Van de Garde, Ewoudt M.W.; Bos, Willem Jan W; Biesma, Douwe H.; Endeman, Henrik; Hardeman, Hans; Heijligenberg, Rik; Meijvis, Sabine C A; Remmelts, Hilde H.F.; van Velzen-Blad, Heleen; Voorn, Paul G P

    2017-01-01

    Background and objective: Mortality after hospitalization with community-acquired pneumonia (CAP) is high, compared with age-matched controls. Available evidence suggests a strong link with cardiovascular disease. Our aim was to explore the prognostic value of high-sensitivity cardiac troponin T

  1. Prognostic value of high sensitive C-reactive protein in subjects with silent myocardial ischemia

    DEFF Research Database (Denmark)

    Mouridsen, Mette; Intzilakis, Theodoros; Binici, Zeynep

    2012-01-01

    . High-sensitive CRP and 48-hour ambulatory ECG monitoring were performed. The primary endpoint was the combined endpoint of death and myocardial infarction. RESULTS: The median follow-up time was 76 months. Seventy-seven subjects (11.4%) had SMI. The combined endpoint occurred in 26% of the subjects...

  2. Resting serum concentration of high-sensitivity C-reactive protein ...

    African Journals Online (AJOL)

    Resting serum concentration of high-sensitivity C-reactive protein (hs-CRP) in sportsmen and untrained male adults. F.A. Niyi-Odumosu, O. A. Bello, S.A. Biliaminu, B.V. Owoyele, T.O. Abu, O.L. Dominic ...

  3. Development of a high sensitivity monitor for radionuclides characterization. Final report, August 1995--April 1996

    International Nuclear Information System (INIS)

    1996-06-01

    This report describes the development of a high sensitivity monitor for radiation, and the feasibility of applying a new radiation imaging concept developed for medical research to soil contamination. The concept utilizes sensors with storage photostimulable phosphor technology as radiation detectors. They are applicable to all types of radiation including tritium

  4. Development of a high sensitivity monitor for radionuclides characterization. Final report, August 1995--April 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    This report describes the development of a high sensitivity monitor for radiation, and the feasibility of applying a new radiation imaging concept developed for medical research to soil contamination. The concept utilizes sensors with storage photostimulable phosphor technology as radiation detectors. They are applicable to all types of radiation including tritium.

  5. Telemetry of Aerial Radiological Measurements

    International Nuclear Information System (INIS)

    Clark, H. W. Jr.

    2002-01-01

    Telemetry has been added to National Nuclear Security Administration's (NNSA's) Aerial Measuring System (AMS) Incident Response aircraft to accelerate availability of aerial radiological mapping data. Rapid aerial radiological mapping is promptly performed by AMS Incident Response aircraft in the event of a major radiological dispersal. The AMS airplane flies the entire potentially affected area, plus a generous margin, to provide a quick look at the extent and severity of the event. The primary result of the AMS Incident Response over flight is a map of estimated exposure rate on the ground along the flight path. Formerly, it was necessary to wait for the airplane to land before the map could be seen. Now, while the flight is still in progress, data are relayed via satellite directly from the aircraft to an operations center, where they are displayed and disseminated. This permits more timely utilization of results by decision makers and redirection of the mission to optimize its value. The current telemetry capability can cover all of North America. Extension to a global capability is under consideration

  6. Wisdom for Building the Project Manager/Project Sponsor Relationship: Partnership for Project Success

    National Research Council Canada - National Science Library

    Patton, Nanette; Shechet, Allan

    2007-01-01

    The project sponsor can promote information technology (IT) project success in several ways, yet many projects either have no formally designated project sponsor or the project sponsor is confused about his/her...

  7. Air-to-Air UAV Aerial Refueling

    Data.gov (United States)

    National Aeronautics and Space Administration — Armstrong researchers, in cooperation with Northrop Grumman Corporation and the Defense Advanced Research Projects Agency (DARPA) demonstrated autonomous aerial...

  8. Dropsonde System for Unmanned Aerial Vehicles Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Unmanned Aerial Vehicles (UAVs) are assuming more numerous and increasingly important roles in global environmental and atmospheric research. There is a...

  9. Confidentiality Enhancement of Highly Sensitive Nuclear Data Using Steganography with Chaotic Encryption over OFDM Channel

    International Nuclear Information System (INIS)

    Mahmoud, S.; Ayad, N.; Elsayed, F.; Elbendary, M.

    2016-01-01

    Full text: Due to the widespread usage of the internet and other wired and wireless communication methods, the security of the transmitted data has become a major requirement. Nuclear knowledge is mainly built upon the exchange of nuclear information which is considered highly sensitive information, so its security has to be enhanced by using high level security mechanisms. Data confidentiality is concerned with the achievement of higher protection for confidential information from unauthorized disclosure or access. Cryptography and steganography are famous and widely used techniques that process information in order to achieve its confidentiality, but sometimes, when used individually, they don’t satisfy a required level of security for highly sensitive data. In this paper, cryptography is accompanied with steganography for constituting a multilayer security techniques that can strengthen the level of security of highly confidential nuclear data that are archived or transmitted through different channel types and noise conditions. (author)

  10. Photon Counting System for High-Sensitivity Detection of Bioluminescence at Optical Fiber End.

    Science.gov (United States)

    Iinuma, Masataka; Kadoya, Yutaka; Kuroda, Akio

    2016-01-01

    The technique of photon counting is widely used for various fields and also applicable to a high-sensitivity detection of luminescence. Thanks to recent development of single photon detectors with avalanche photodiodes (APDs), the photon counting system with an optical fiber has become powerful for a detection of bioluminescence at an optical fiber end, because it allows us to fully use the merits of compactness, simple operation, highly quantum efficiency of the APD detectors. This optical fiber-based system also has a possibility of improving the sensitivity to a local detection of Adenosine triphosphate (ATP) by high-sensitivity detection of the bioluminescence. In this chapter, we are introducing a basic concept of the optical fiber-based system and explaining how to construct and use this system.

  11. Silicon on-chip bandpass filters for the multiplexing of high sensitivity photonic crystal microcavity biosensors

    International Nuclear Information System (INIS)

    Yan, Hai; Zou, Yi; Yang, Chun-Ju; Chakravarty, Swapnajit; Wang, Zheng; Tang, Naimei; Chen, Ray T.; Fan, Donglei

    2015-01-01

    A method for the dense integration of high sensitivity photonic crystal (PC) waveguide based biosensors is proposed and experimentally demonstrated on a silicon platform. By connecting an additional PC waveguide filter to a PC microcavity sensor in series, a transmission passband is created, containing the resonances of the PC microcavity for sensing purpose. With proper engineering of the passband, multiple high sensitivity PC microcavity sensors can be integrated into microarrays and be interrogated simultaneously between a single input and a single output port. The concept was demonstrated with a 2-channel L55 PC biosensor array containing PC waveguide filters. The experiment showed that the sensors on both channels can be monitored simultaneously from a single output spectrum. Less than 3 dB extra loss for the additional PC waveguide filter is observed

  12. Silicon on-chip bandpass filters for the multiplexing of high sensitivity photonic crystal microcavity biosensors

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Hai, E-mail: hai.yan@utexas.edu; Zou, Yi; Yang, Chun-Ju [Department of Electrical and Computer Engineering, Microelectronics Research Center, The University of Texas at Austin, 10100 Burnet Rd., Austin, Texas 78758 (United States); Chakravarty, Swapnajit, E-mail: swapnajit.chakravarty@omegaoptics.com [Omega Optics, Inc., 8500 Shoal Creek Blvd., Austin, Texas 78757 (United States); Wang, Zheng [Department of Electrical and Computer Engineering, Microelectronics Research Center, The University of Texas at Austin, 10100 Burnet Rd., Austin, Texas 78758 (United States); Materials Science and Engineering Program, Texas Materials Institute, The University of Texas at Austin, Austin, Texas 78712 (United States); Tang, Naimei; Chen, Ray T., E-mail: raychen@uts.cc.utexas.edu [Department of Electrical and Computer Engineering, Microelectronics Research Center, The University of Texas at Austin, 10100 Burnet Rd., Austin, Texas 78758 (United States); Omega Optics, Inc., 8500 Shoal Creek Blvd., Austin, Texas 78757 (United States); Fan, Donglei [Materials Science and Engineering Program, Texas Materials Institute, The University of Texas at Austin, Austin, Texas 78712 (United States); Department of Mechanical Engineering, The University of Texas at Austin, Austin, Texas 78712 (United States)

    2015-03-23

    A method for the dense integration of high sensitivity photonic crystal (PC) waveguide based biosensors is proposed and experimentally demonstrated on a silicon platform. By connecting an additional PC waveguide filter to a PC microcavity sensor in series, a transmission passband is created, containing the resonances of the PC microcavity for sensing purpose. With proper engineering of the passband, multiple high sensitivity PC microcavity sensors can be integrated into microarrays and be interrogated simultaneously between a single input and a single output port. The concept was demonstrated with a 2-channel L55 PC biosensor array containing PC waveguide filters. The experiment showed that the sensors on both channels can be monitored simultaneously from a single output spectrum. Less than 3 dB extra loss for the additional PC waveguide filter is observed.

  13. High sensitive LPFG magnetic field sensor based on dual-peak resonance

    Science.gov (United States)

    Gu, Zhengtian; Ling, Qiang; Lan, Jinlong; Gao, Kan

    2017-11-01

    A high sensitivity magnetic field sensor based on magnetic-fluid-clad LPFG structure with dual peak resonance is presented and experimentally investigated. Based on coupled mode theory, the sensing principle of this sensor is originated from the sensibility of the dual peak based LPFG to the environment refractive index. In experiment, a dual peak interval change was available to 38 nm with a magnetic field strength varying from 0 to 12 mT when the temperature was 17.3 °C, and the dual peak interval displays a cubic polynomial dependence with the magnetic field strength at the low field regime. The sensitivity of this sensor to the magnetic field can be available to 4.08 nm/mT, and it is one order and two orders of magnitude higher than that of the sensors based on MSM and SMS fiber structure, respectively. The novel sensor has many advantages of simple technology, structure stability and high sensitivity.

  14. High Sensitivity Magnetic Field Sensors Based on Nano-Polysilicon Thin-Film Transistors

    International Nuclear Information System (INIS)

    Zhao Xiao-Feng; Wen Dian-Zhong; Zhuang Cui-Cui; Liu Gang; Wang Zhi-Qiang

    2012-01-01

    A high-sensitivity magnetic field sensor based on the nano-polysilicon thin film transistors is proposed to adopt the nano-polysilicon thin films and the nano-polysilicon/single silicon heterojunction interfaces as the sensing layers. By using CMOS technology, the fabrication of the nano-polysilicon thin film transistors with Hall probes can be achieved on the 〈100〉 high resistivity single silicon substrates, in which the thicknesses of the nano-polysilicon thin films are 120 nm and the length width ratio of the channel is 320 μm/80 μm. When V DS = 5.0 V, the magnetic sensitivity and linearity is 264 mV/T and 0.23%f.s. (full scale), respectively. The experimental results show that the magnetic sensors based on nano-polysilicon thin film transistors with Hall probes exhibit high sensitivity

  15. Association between high-sensitive troponin I and coronary artery calcification in a Danish general population

    DEFF Research Database (Denmark)

    Olson, Fredrik; Engborg, Jonathan; Grønhøj, Mette H.

    2016-01-01

    BACKGROUND: High-sensitive troponin I (hs-TnI) is an individual predictor of future cardiovascular disease (CVD). However, the relationship between hs-TnI and coronary artery calcification (CAC) as determined by computed tomography (CT) has not previously been investigated in a general population....... METHODS: 1173 randomized, middle-aged subjects without known CVD underwent a non-contrast cardiac-CT scan for CAC determination. Hs-TnI was detected using ARCHITECT STAT High Sensitive Troponin-I immunoassay. Total 10-year cardiovascular mortality risk was estimated using HeartScore. The relationship.......695 (p population without previously known CVD. This is a step towards understanding hs-TnI as a risk marker for CVD....

  16. Quartz crystal microbalance-based system for high-sensitivity differential sputter yield measurements

    International Nuclear Information System (INIS)

    Rubin, B.; Topper, J. L.; Farnell, C. C.; Yalin, A. P.

    2009-01-01

    We present a quartz crystal microbalance-based system for high sensitivity differential sputter yield measurements of different target materials due to ion bombardment. The differential sputter yields can be integrated to find total yields. Possible ion beam conditions include ion energies in the range of 30-350 eV and incidence angles of 0 deg. - 70 deg. from normal. A four-grid ion optics system is used to achieve a collimated ion beam at low energy (<100 eV) and a two-grid ion optics is used for higher energies (up to 750 eV). A complementary weight loss approach is also used to measure total sputter yields. Validation experiments are presented that confirm high sensitivity and accuracy of sputter yield measurements.

  17. A highly sensitive RF-to-DC power converter with an extended dynamic range

    KAUST Repository

    Almansouri, Abdullah Saud Mohammed

    2017-10-24

    This paper proposes a highly sensitive RF-to-DC power converter with an extended dynamic range that is designed to operate at the medical band 433 MHz and simulated using 0.18 μm CMOS technology. Compared to the conventional fully cross-coupled rectifier, the proposed design offers 3.2× the dynamic range. It is also highly sensitive and requires −18 dBm of input power to produce a 1 V-output voltage when operating with a 100 kΩ load. Furthermore, the proposed design offers an open circuit sensitivity of −23.4 dBm and a peak power conversion efficiency of 67%.

  18. Nanowire-templated microelectrodes for high-sensitivity pH detection

    DEFF Research Database (Denmark)

    Antohe, V.A.; Radu, Adrian; Mátéfi-Tempfli, Mária

    2009-01-01

    A highly sensitive pH capacitive sensor has been designed by confined growth of vertically aligned nanowire arrays on interdigited microelectrodes. The active surface of the device has been functionalized with an electrochemical pH transducer (polyaniline). We easily tune the device features...... by combining lithographic techniques with electrochemical synthesis. The reported electrical LC resonance measurements show considerable sensitivity enhancement compared to conventional capacitive pH sensors realized with microfabricated interdigited electrodes. The sensitivity can be easily improved...

  19. Silicon/Porous Silicon Composite Membrane for High Sensitivity Pressure Sensor

    Science.gov (United States)

    2009-07-21

    for integrating with other processes on silicon wafer. The fabrication of silicone rubber membranes for making microvalves has been reported [5...alcohol (IPA) is used along with HF to increase the wettability of the silicon surface and to remove the bubbles formed during the reaction. Aluminium ...Report for AOARD funded Project No. AOARD-074061 Title: Silicon /Porous Silicon composite membrane for high sensitivity pressure sensor PI

  20. High?Sensitivity Troponin: A Clinical Blood Biomarker for Staging Cardiomyopathy in Fabry Disease

    OpenAIRE

    Seydelmann, Nora; Liu, Dan; Kr?mer, Johannes; Drechsler, Christiane; Hu, Kai; Nordbeck, Peter; Schneider, Andreas; St?rk, Stefan; Bijnens, Bart; Ertl, Georg; Wanner, Christoph; Weidemann, Frank

    2016-01-01

    Background High?sensitivity troponin (hs?TNT), a biomarker of myocardial damage, might be useful for assessing fibrosis in Fabry cardiomyopathy. We performed a prospective analysis of hs?TNT as a biomarker for myocardial changes in Fabry patients and a retrospective longitudinal follow?up study to assess longitudinal hs?TNT changes relative to fibrosis and cardiomyopathy progression. Methods and Results For the prospective analysis, hs?TNT from 75 consecutive patients with genetically confirm...

  1. A Microneedle Functionalized with Polyethyleneimine and Nanotubes for Highly Sensitive, Label-Free Quantification of DNA

    OpenAIRE

    Saadat-Moghaddam, Darius; Kim, Jong-Hoon

    2017-01-01

    The accurate measure of DNA concentration is necessary for many DNA-based biological applications. However, the current methods are limited in terms of sensitivity, reproducibility, human error, and contamination. Here, we present a microneedle functionalized with polyethyleneimine (PEI) and single-walled carbon nanotubes (SWCNTs) for the highly sensitive quantification of DNA. The microneedle was fabricated using ultraviolet (UV) lithography and anisotropic etching, and then functionalized w...

  2. Highly sensitive determination of hydrogen peroxide and glucose by fluorescence correlation spectroscopy.

    Directory of Open Access Journals (Sweden)

    Satoshi Watabe

    Full Text Available BACKGROUND: Because H(2O(2 is generated by various oxidase-catalyzed reactions, a highly sensitive determination method of H(2O(2 is applicable to measurements of low levels of various oxidases and their substrates such as glucose, lactate, glutamate, urate, xanthine, choline, cholesterol and NADPH. We propose herein a new, highly sensitive method for the measurement of H(2O(2 and glucose using fluorescence correlation spectroscopy (FCS. METHODOLOGY/PRINCIPAL FINDINGS: FCS has the advantage of allowing us to determine the number of fluorescent molecules. FCS measures the fluctuations in fluorescence intensity caused by fluorescent probe movement in a small light cavity with a defined volume generated by confocal illumination. We thus developed a highly sensitive determination system of H(2O(2 by FCS, where horseradish peroxidase (HRP catalyzes the formation of a covalent bond between fluorescent molecules and proteins in the presence of H(2O(2. Our developed system gave a linear calibration curve for H(2O(2 in the range of 28 to 300 nM with the detection limit of 8 nM. In addition, by coupling with glucose oxidase (GOD-catalyzed reaction, the method allows to measure glucose in the range of 80 nM to 1.5 µM with detection limit of 24 nM. The method was applicable to the assay of glucose in blood plasma. The mean concentration of glucose in normal human blood plasma was determined to be 4.9 mM. CONCLUSIONS/SIGNIFICANCE: In comparison with commercial available methods, the detection limit and the minimum value of determination for glucose are at least 2 orders of magnitude more sensitive in our system. Such a highly sensitive method leads the fact that only a very small amount of plasma (20 nL is needed for the determination of glucose concentration in blood plasma.

  3. CONSTRUCTION OF A DIFFERENTIAL ISOTHERMAL CALORIMETER OF HIGH SENSITIVITY AND LOW COST.

    OpenAIRE

    Trinca, RB; Perles, CE; Volpe, PLO

    2009-01-01

    CONSTRUCTION OF A DIFFERENTIAL ISOTHERMAL CALORIMETER OF HIGH SENSITIVITY AND LOW COST The high cost of sensitivity commercial calorimeters may represent an obstacle for many calorimetric research groups. This work describes (fie construction and calibration of a batch differential heat conduction calorimeter with sample cells volumes of about 400 mu L. The calorimeter was built using two small high sensibility square Peltier thermoelectric sensors and the total cost was estimated to be about...

  4. Highly sensitive dual mode electrochemical platform for microRNA detection

    OpenAIRE

    Jolly, Pawan; Batistuti, Marina R.; Miodek, Anna; Zhurauski, Pavel; Mulato, Marcelo; Lindsay, Mark A.; Estrela, Pedro

    2016-01-01

    MicroRNAs (miRNAs) play crucial regulatory roles in various human diseases including cancer, making them promising biomarkers. However, given the low levels of miRNAs present in blood, their use as cancer biomarkers requires the development of simple and effective analytical methods. Herein, we report the development of a highly sensitive dual mode electrochemical platform for the detection of microRNAs. The platform was developed using peptide nucleic acids as probes on gold electrode surfac...

  5. Capacitively-coupled differential position detection in the development of a high-sensitivity torsion balance

    Science.gov (United States)

    Rackson, Charles; Watt, Alex; Kim, Woo-Joong; Seattle University Team

    2015-03-01

    We report on the development of a high-sensitivity torsion balance using a capacitively-coupled Wheatstone Bridge. The torsion balance will be employed to measure the Casimir Force, with a particular emphasis on the surface patch effects that are ubiquitous on metallic surfaces. We will show that these effects also play a significant role in another class of experiments involving quantum-point contacts between two metal wires.

  6. Use of High Sensitivity GNSS Receiver Doppler Measurements for Indoor Pedestrian Dead Reckoning

    OpenAIRE

    Renaudin, Valérie; ZHE, He; PETOVELLO, Mark G.; Lachapelle, Gérard

    2013-01-01

    Dead-reckoning (DR) algorithms, which use self-contained inertial sensors combined with gait analysis, have proven to be effective for pedestrian navigation purposes. In such DR systems, the primary error is often due to accumulated heading drifts. By tightly integrating global navigation satellite system (GNSS) Doppler measurements with DR, such accumulated heading errors can usually be accurately compensated. Under weak signal conditions, high sensitivity GNSS (HSGNSS) receivers with block ...

  7. Shunts due to laser scribing of solar cells evaluated by highly sensitive lock-in thermography

    Energy Technology Data Exchange (ETDEWEB)

    Breitenstein, O.; Langenkamp, M. [Max-Planck-Institut fuer Mikrostrukturphysik, Weinberg 2, D-06120 Halle (Germany); Lang, O. [SOLARC, Gustav-Meyer-Allee 25, Geb. 12, D-13355 Berlin (Germany); Schirrmacher, A. [LMTB, Rudower Chaussee 6, Geb. 19/2, D-12489 Berlin (Germany)

    2001-01-01

    Using a 217Hz focal plane array (FPA) thermocamera attached to two parallel-running DSP frame grabber boards in a PC, a highly sensitive lock-in thermography system has been built, enabling the detection of periodic surface temperature oscillations below 10{mu}K (r.m.s). This system has been used to investigate edge leakage currents in silicon solar cells after laser scribing and cleavage.

  8. 12th Rencontres du Vietnam : High Sensitivity Experiments Beyond the Standard Model

    CERN Document Server

    2016-01-01

    The goal of this workshop is to gather researchers, theoreticians, experimentalists and young scientists searching for physics beyond the Standard Model of particle physics using high sensitivity experiments. The standard model has been very successful in describing the particle physics world; the Higgs-Englert-Brout boson discovery is its last major discovery. Complementary to the high energy frontier explored at colliders, real opportunities for discovery exist at the precision frontier, testing fundamental symmetries and tracking small SM deviations.

  9. A Spherical Aerial Terrestrial Robot

    Science.gov (United States)

    Dudley, Christopher J.

    This thesis focuses on the design of a novel, ultra-lightweight spherical aerial terrestrial robot (ATR). The ATR has the ability to fly through the air or roll on the ground, for applications that include search and rescue, mapping, surveillance, environmental sensing, and entertainment. The design centers around a micro-quadcopter encased in a lightweight spherical exoskeleton that can rotate about the quadcopter. The spherical exoskeleton offers agile ground locomotion while maintaining characteristics of a basic aerial robot in flying mode. A model of the system dynamics for both modes of locomotion is presented and utilized in simulations to generate potential trajectories for aerial and terrestrial locomotion. Details of the quadcopter and exoskeleton design and fabrication are discussed, including the robot's turning characteristic over ground and the spring-steel exoskeleton with carbon fiber axle. The capabilities of the ATR are experimentally tested and are in good agreement with model-simulated performance. An energy analysis is presented to validate the overall efficiency of the robot in both modes of locomotion. Experimentally-supported estimates show that the ATR can roll along the ground for over 12 minutes and cover the distance of 1.7 km, or it can fly for 4.82 minutes and travel 469 m, on a single 350 mAh battery. Compared to a traditional flying-only robot, the ATR traveling over the same distance in rolling mode is 2.63-times more efficient, and in flying mode the system is only 39 percent less efficient. Experimental results also demonstrate the ATR's transition from rolling to flying mode.

  10. Current status on the evaluation and management of the highly sensitized kidney transplant recipient.

    Science.gov (United States)

    Kumar, Vineeta

    2015-11-01

    In light of the recent changes to the kidney allocation system (KAS) and the observed increase in the rate of transplantation of the highly sensitized kidney transplant candidate, the evaluation and care of this population is a timely topic. In its first year, the new KAS has already realized one goal of improving the chances of transplanting the most highly sensitized patients in the waiting list. This has brought to the forefront the need for recipient readiness in this special population, as well as the need for histocompatibility labs and kidney transplant programs to align themselves with each other, and also with the requirements of the United Network for Organ Sharing, and increase proficiency in testing and data interpretation. This manuscript is a review of the literature as well as practice patterns as they relate to the changes in KAS and the observed outcome since the activation of the new KAS, with the ultimate goal of aiding in the development of a more unified approach in the care of this specialized population which will allow for interdisciplinary and cross centre dialogue to optimize long term care and outcomes. Here we will review the changes to the KAS as they affect the highly sensitized kidney transplant recipient, and additional considerations in the evaluation and management of these patients.

  11. Highly Sensitive Chemical Sensor Based on CuO Rosette-Like Nanostructures.

    Science.gov (United States)

    Umar, Ahmad

    2015-09-01

    This paper reports the successful fabrication and characterization of phenyl hydrazine chemical sensor based on CuO rosette-like nanostructures. The CuO rosette-like nanostructures were synthesized by facile hydrothermal process at low-temperature and characterized in detail in terms of their morphological, structural and compositional properties. The detailed morphological studies revealed that the prepared CuO rosettes are made by the accumulation of hundreds of small CuO nanodisks which are arranged in a special fashion that they made rosette-like morphologies. The structural characterization, by X-ray diffraction (XRD), confirmed that the prepared CuO rosette-like structures are nanocrystalline and possessing monoclinic structure. The compositional studies further substantiates that the synthesized rosette-like morphologies are pure CuO. The fabricated phenyl hydrazine chemical sensor based on CuO rosette-like nanostructures exhibited very high sensitivity of -49.532710 μA/cm2 x mM. Due to high sensitivity, it can be concluded that CuO rosette-like nanostructures could be an effective candidate for the fabrication of highly sensitive phenyl hydrazine chemical sensors.

  12. Aerial Refueling Clearance Process Guide

    Science.gov (United States)

    2014-08-21

    R. 4.9.3 Ball Valve/Leakage R. dhkARSAG DOC dtd. 6dec. 13; rev.21jan.14 Aerial Refueling Tanker/Receiver Clearance Compatibility Assessment Checklist...Clearance 9.6 Receiver Canopy/Boom Clearance 9.7 Lightning /Static Discharge Impact 10. Standards Compliance 10.1 STANAG 7191 Boom/ Recp. 10.2 AR...Type R. 4.9.1 Gate/Leakage R. 4.9.2 Poppet/Leakage R. 4.9.3 Ball Valve/Leakage R. 4.9.4 Other Leakage Source R. 4.10 Fuel Ingestion Hazard……... R. 5.0

  13. Criminal implication of sponsoring in medicine: legal ramifactions and recommendations

    International Nuclear Information System (INIS)

    Mahnken, A.H.; Guenther, R.W.; Theilmann, M.; Bolenz, M.

    2005-01-01

    As a consequence of the so-called ''Heart-Valve-Affair'' in 1994, the German public became aware of the potential criminal significance of industrial sponsoring and third-party financial support in medicine. Since 1997, when the German Anti-Corruption Law came into effect, the penal regulations regarding bribery and benefits for public officers were tightened. Due to the lack of explicit and generally accepted guidelines in combination with regional differences of jurisdiction, there is a lingering uncertainty regarding the criminal aspects of third-party funding and industrial sponsoring. The aim of this review is to summarize the penal and professional implications of third-party funding and sponsoring in medicine including recent aspects of jurisdiction. The currently available recommendations on this issue are introduced. (orig.)

  14. [Criminal implication of sponsoring in medicine: legal ramifactions and recommendations].

    Science.gov (United States)

    Mahnken, A H; Theilmann, M; Bolenz, M; Günther, R W

    2005-08-01

    As a consequence of the so-called "Heart-Valve-Affair" in 1994, the German public became aware of the potential criminal significance of industrial sponsoring and third-party financial support in medicine. Since 1997, when the German Anti-Corruption Law came into effect, the penal regulations regarding bribery and benefits for public officers were tightened. Due to the lack of explicit and generally accepted guidelines in combination with regional differences of jurisdiction, there is a lingering uncertainty regarding the criminal aspects of third-party funding and industrial sponsoring. The aim of this review is to summarize the penal and professional implications of third-party funding and sponsoring in medicine including recent aspects of jurisdiction. The currently available recommendations on this issue are introduced.

  15. Modelling Emotional and Attitudinal Evaluations of Major Sponsors

    DEFF Research Database (Denmark)

    Martensen, Anne; Hansen, Flemming

    2004-01-01

    equation model where the drivers are attitudes towards thesponsorship and emotions towards the sponsorship. It is found that the two classes ofvariables describe different aspects of the perception of sponsorships, and that they bothcontribute significantly to the overall value of sponsoring...... for a particular company. In thepresent paper, two cases are shown for two major sponsors. The specified Sponsor ValueModel is estimated by a partial least squares (PLS) method. It is found that the two sponsorsare perceived differently, both in terms of emotional and attitudinal responses. It is also foundthat...... the emotional responses aroused by the sponsorships are at least as important as thoseascribable to attitudinal elements.Key words: Sponsorship, emotional response, attitudes towards sponsorship, structuralequation model...

  16. Hierarchical control of aerial manipulation vehicle

    Science.gov (United States)

    Kannan, Somasundar; Bezzaoucha, Souad; Guzman, Serket Quintanar; Dentler, Jan; Olivares-Mendez, Miguel A.; Voos, Holger

    2017-01-01

    Hierarchical Control of the Aerial Manipulator is treated here. The modelling aspect of the highly coupled Aerial Vehicle which includes Quadrotor and manipulator is discussed. The control design to perform tasks in operational space is addressed along with stability discussion. The simulation studies are successfully performed to validate the design methodology.

  17. Variable impedance control for aerial interaction

    NARCIS (Netherlands)

    Mersha, A.Y.; Stramigioli, Stefano; Carloni, Raffaella

    This paper presents a versatile control architecture for aerial robots in interactive tasks. The control architecture is characterized by its unique capability of varying the apparent impedance of the controlled aerial robot as well as the interaction force, when in contact. This work finds its way

  18. Aerial service robotics: the AIRobots perspective

    NARCIS (Netherlands)

    Marconi, L.; Basile, F.; Caprari, G.; Carloni, Raffaella; Chiacchio, P.; Hurzeler, C.; Lippiello, V.; Naldi, R.; Siciliano, B.; Stramigioli, Stefano; Zwicker, E.

    This paper presents the main vision and research activities of the ongoing European project AIRobots (Innova- tive Aerial Service Robot for Remote Inspection by Contact, www.airobots.eu). The goal of AIRobots is to develop a new generation of aerial service robots capable of supporting human beings

  19. On autonomous and teleoperated aerial service robots

    NARCIS (Netherlands)

    Mersha, A.Y.

    2014-01-01

    Traditionally, aerial robots have been used in applications that do not require physical interaction with the environment. Recently, however, there is a growing interest in using aerial robots for applications that involve active but nondestructive interaction with the environment, especially in the

  20. 45 CFR 2552.23 - What are a sponsor's program responsibilities?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are a sponsor's program responsibilities... Sponsor § 2552.23 What are a sponsor's program responsibilities? A sponsor shall: (a) Focus Foster... project's service area. (b) Assess in collaboration with other community organizations or utilize existing...

  1. 45 CFR 2551.23 - What are a sponsor's program responsibilities?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are a sponsor's program responsibilities... Sponsor § 2551.23 What are a sponsor's program responsibilities? A sponsor shall: (a) Focus Senior... within the project's service area. (b) Assess in collaboration with other community organizations or...

  2. 45 CFR 2552.25 - What are a sponsor's administrative responsibilities?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are a sponsor's administrative... a Sponsor § 2552.25 What are a sponsor's administrative responsibilities? A sponsor shall: (a... delegated to project staff for NSSC program(s) within its control. A full-time project director shall not...

  3. 45 CFR 2551.25 - What are a sponsor's administrative responsibilities?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are a sponsor's administrative... Sponsor § 2551.25 What are a sponsor's administrative responsibilities? A sponsor shall: (a) Assume full... program(s) within its control. A full-time project director shall not serve concurrently in another...

  4. 45 CFR 2553.25 - What are a sponsor's administrative responsibilities?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are a sponsor's administrative... Responsibilities of a Sponsor § 2553.25 What are a sponsor's administrative responsibilities? A sponsor shall: (a... delegated to project staff for NSSC program(s) within its control. A full-time project director shall not...

  5. 45 CFR 2553.23 - What are a sponsor's program responsibilities?

    Science.gov (United States)

    2010-10-01

    ... Responsibilities of a Sponsor § 2553.23 What are a sponsor's program responsibilities? A sponsor shall: (a) Focus RSVP resources to have a positive impact on critical human and social needs within the project service... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are a sponsor's program responsibilities...

  6. Serial measurements of high-sensitivity cardiac troponin T after exercise stress test in stable coronary artery disease

    DEFF Research Database (Denmark)

    Axelsson, Anna; Ruwald, Martin Huth; Dalsgaard, Morten

    2013-01-01

    The aim was to assess serial measurements of high-sensitivity cardiac troponin T (hs-cTNT) post-exercise in patients with stable coronary artery disease (CAD).......The aim was to assess serial measurements of high-sensitivity cardiac troponin T (hs-cTNT) post-exercise in patients with stable coronary artery disease (CAD)....

  7. A Commentary on Literacy Narratives as Sponsors of Literacy

    Science.gov (United States)

    Brandt, Deborah

    2015-01-01

    This brief commentary first clarifies Brandt's concept of sponsors of literacy in light of the way the concept has been taken up in writing studies. Then it treats Brandt's methods for handling accounts of literacy learning in comparison with other ways of analyzing biographical material. Finally it takes up Lawrence's argument about literacy…

  8. Sponsorship recall and recognition of official sponsors of the 2010 ...

    African Journals Online (AJOL)

    With escalating interest in sports globally, sport sponsorship has emerged as a platform that provides sponsoring companies with a chance of securing a competitive advantage. Events of high magnitude such as the 2010 FIFA World Cup™, which was the world's largest football event hosted in South Africa (SA), offered ...

  9. Tax Exempt Organizations and Commercially Sponsored Scientific Research.

    Science.gov (United States)

    Kertz, Consuelo Lauda

    1982-01-01

    Several related tax issues important to both the commercial sponsors and tax-exempt recipients of research funding are addressed: what type of activity qualified as scientific research; how acceptance of commercial funding affects tax-exempt status; and when the receipt of such funding generates a liability for tax on unrelated business income.…

  10. 7 CFR 225.14 - Requirements for sponsor participation.

    Science.gov (United States)

    2010-01-01

    ... 225.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM Sponsor and Site Provisions... Youth Sports Program; and (5) Private nonprofit organizations as defined in § 225.2. (c) General...

  11. A DST Sponsored Workshop on Methods in Behavioural Ecology ...

    Indian Academy of Sciences (India)

    A DST Sponsored Workshop on Methods in. Behavioural Ecology. Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560 012, India. 15-29 January 2006. Aimed at Young Teachers and Senior Research Students The course will cover lectures on several aspects of Behavioral ecology including, ...

  12. 22 CFR 42.31 - Family-sponsored immigrants.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Family-sponsored immigrants. 42.31 Section 42.31 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Immigrants Subject to Numerical Limitations § 42.31 Family...

  13. The relationship between absenteeism and employer-sponsored ...

    African Journals Online (AJOL)

    The relationship between absenteeism and employer-sponsored child care. B Anderson, DJ Geldenhuys. Abstract. Given the high loss of revenue due to absenteeism, exploring different ways of managing absenteeism in South African companies, such as family-friendly practices, has become important. Establishing onsite

  14. Highlight: IDRC sponsors Caribbean symposium on impact of ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2015-05-12

    12 mai 2015 ... An IDRC-sponsored symposium exploring the impact of the Internet on economic growth and public service delivery in the Caribbean was held in Saint Andrew, Jamaica, on May 12, 2015. Discussions from the symposium will feed into the 2016 World Development Report: Internet for Development.

  15. Exclusion of pregnant women from industry-sponsored clinical trials.

    Science.gov (United States)

    Shields, Kristine E; Lyerly, Anne Drapkin

    2013-11-01

    The lack of human data available to inform evidence-based treatment for illness during pregnancy has led to calls for greater inclusion of pregnant women in research, but the extent of their current representation is poorly characterized. Our objective was to measure the current exclusion of pregnant women from industry-sponsored clinical trials as a baseline for future comparison. We compiled data from studies enrolling women of childbearing potential posted on www.ClinicalTrials.gov between 1 October 2011 and 31 January 2012. The review was limited to open United States-based phase IV interventional studies sponsored by the pharmaceutical industry evaluating treatment of conditions that may be experienced by but are not limited to pregnant women and did not involve a medication classified as potentially teratogenic. If there was no mention of pregnancy in the inclusion or exclusion criteria, we contacted a study representative to confirm that pregnant women could be enrolled. Of 558 qualifying industry-sponsored studies, five (1%) were designed specifically for pregnant women. Of 367 phase IV clinical trials with verified inclusion and exclusion criteria, 348 (95%) excluded pregnant women and 19 (5%) did not. We found the exclusion of pregnant women from industry-sponsored clinical trials to be common practice. Moving beyond reflexive exclusion and developing thoughtful criteria for inclusion of pregnant women in clinical research would likely advance the evidence base to inform treatment decisions during pregnancy and lead to better health outcomes for women and children.

  16. Media exposure and sponsor recall: Cricket World Cup 2003 | Van ...

    African Journals Online (AJOL)

    This paper reports on a study into the relationship between media exposure and sponsor recall relating to an international event, namely the Cricket World Cup 2003 (CWC 2003). The application of sponsorship as a communication construct and recall as a media vehicle effect is investigated. Recall has been widely ...

  17. Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling.

    Science.gov (United States)

    Plagnol, Vincent; Woodhouse, Samuel; Howarth, Karen; Lensing, Stefanie; Smith, Matt; Epstein, Michael; Madi, Mikidache; Smalley, Sarah; Leroy, Catherine; Hinton, Jonathan; de Kievit, Frank; Musgrave-Brown, Esther; Herd, Colin; Baker-Neblett, Katherine; Brennan, Will; Dimitrov, Peter; Campbell, Nathan; Morris, Clive; Rosenfeld, Nitzan; Clark, James; Gale, Davina; Platt, Jamie; Calaway, John; Jones, Greg; Forshew, Tim

    2018-01-01

    Circulating tumor DNA (ctDNA) analysis is being incorporated into cancer care; notably in profiling patients to guide treatment decisions. Responses to targeted therapies have been observed in patients with actionable mutations detected in plasma DNA at variant allele fractions (VAFs) below 0.5%. Highly sensitive methods are therefore required for optimal clinical use. To enable objective assessment of assay performance, detailed analytical validation is required. We developed the InVisionFirst™ assay, an assay based on enhanced tagged amplicon sequencing (eTAm-Seq™) technology to profile 36 genes commonly mutated in non-small cell lung cancer (NSCLC) and other cancer types for actionable genomic alterations in cell-free DNA. The assay has been developed to detect point mutations, indels, amplifications and gene fusions that commonly occur in NSCLC. For analytical validation, two 10mL blood tubes were collected from NSCLC patients and healthy volunteer donors. In addition, contrived samples were used to represent a wide spectrum of genetic aberrations and VAFs. Samples were analyzed by multiple operators, at different times and using different reagent Lots. Results were compared with digital PCR (dPCR). The InVisionFirst assay demonstrated an excellent limit of detection, with 99.48% sensitivity for SNVs present at VAF range 0.25%-0.33%, 92.46% sensitivity for indels at 0.25% VAF and a high rate of detection at lower frequencies while retaining high specificity (99.9997% per base). The assay also detected ALK and ROS1 gene fusions, and DNA amplifications in ERBB2, FGFR1, MET and EGFR with high sensitivity and specificity. Comparison between the InVisionFirst assay and dPCR in a series of cancer patients showed high concordance. This analytical validation demonstrated that the InVisionFirst assay is highly sensitive, specific and robust, and meets analytical requirements for clinical applications.

  18. TACTIC: a high-sensitivity gamma-ray telescope [Paper No.: I6

    International Nuclear Information System (INIS)

    Bhat, C.L.; Koul, R.; Tickoo, A.K.; Kaul, I.K.; Kaul, S.R.

    1993-01-01

    A high-sensitivity gamma-ray telescope, TACTIC, is being installed at Guru Shikhar, Mt. Abu, for undertaking comprehensive temporal and spectral studies of cosmic sources in the TeG energy range. The design of this instrument combines the optimal operational features of a conventional non-imaging system with the cosmic-ray background rejection capabilities of a new-generation alpha ray telescope to give it a flux sensitivity comparable with that of the stereoscopic imaging system GRANITE, the latest international standard. The salient features of the electronics and instrumentation required for TACTIC are highlighted. (author). 9 refs., 3 figs

  19. Real-time, single-step bioassay using nanoplasmonic resonator with ultra-high sensitivity

    Science.gov (United States)

    Zhang, Xiang; Ellman, Jonathan A; Chen, Fanqing Frank; Su, Kai-Hang; Wei, Qi-Huo; Sun, Cheng

    2014-04-01

    A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.

  20. Design of a new air flow velocity sensor for aspirating high sensitivity smoke detectors

    OpenAIRE

    Córdoba Galera, Andrés

    2015-01-01

    Aspirating detectors use the high sensitivity sensing given by laser technology to detect smoke in the early stages of a fire ignition. To do this, the air is aspirated through pipe conducts to be sampled and analyzed. This air is inserted into a smoke sensor cavity, where a laser emitter and photoreceptor quantify smoke particles present in the air sampled. To assure that the system is working according to the initial conditions during all its life, it is required to have an accurate air-flo...

  1. Development of a highly-sensitive Penning ionization electron spectrometer using the magnetic bottle effect

    Energy Technology Data Exchange (ETDEWEB)

    Ota, Masahiro; Ishiguro, Yuki; Nakajima, Yutaro; Miyauchi, Naoya; Yamakita, Yoshihiro, E-mail: yamakita@uec.ac.jp [Department of Engineering Science, Graduate School of Informatics and Engineering The University of Electro-Communications 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585 (Japan)

    2016-02-01

    This paper reports on a highly-sensitive retarding-type electron spectrometer for a continuous source of electrons, in which the electron collection efficiency is increased by utilizing the magnetic bottle effect. This study demonstrates an application to Penning ionization electron spectroscopy using collisional ionization with metastable He*(2{sup 3}S) atoms. Technical details and performances of the instrument are presented. This spectrometer can be used for studies of functional molecules and assemblies, and exterior electron densities are expected to be selectively observed by the Penning ionization.

  2. Highly sensitive, non-invasive detection of colorectal cancer mutations using single molecule, third generation sequencing

    Directory of Open Access Journals (Sweden)

    Giancarlo Russo

    2015-12-01

    We present the first study that applies the high read accuracy and depth of single molecule, real time, circular consensus sequencing (SMRT-CCS to the detection of mutations in stool DNA in order to provide a non-invasive, sensitive and accurate test for CRC. In stool DNA isolated from patients diagnosed with adenocarcinoma, we are able to detect mutations at frequencies below 0.5% with no false positives. This approach establishes a foundation for a non-invasive, highly sensitive assay to screen the population for CRC and the early stage adenomas that lead to CRC.

  3. Development of a new low cost high sensitivity system for behavioural ecotoxicity testing.

    Science.gov (United States)

    Mills, Chris Lloyd; Shukla, Deepa H; Compton, Graham J

    2006-05-01

    The amphipod Gammarus pulex has been extensively used for ecotoxicological studies. However, the tests used are either labourious to perform and/or require relatively expensive equipment. We report the development of a new low cost infra red actograph system that measures relative activity, and can detect the behavioural effects of very low concentrations of heavy metals. Trials demonstrated that the home built system can distinguish significantly different behaviour between G. pulex exposed to clean water and that contaminated with as low as 10 microg L(-1) copper. This highly sensitive low cost automated system has the potential to become an important tool for ecotoxicity testing and water quality monitoring.

  4. Highly sensitive micromachined capacitive pressure sensor with reduced hysteresis and low parasitic capacitance

    DEFF Research Database (Denmark)

    Pedersen, Thomas; Fragiacomo, Giulio; Hansen, Ole

    2009-01-01

    This paper describes the design and fabrication of a capacitive pressure sensor that has a large capacitance signal and a high sensitivity of 76 pF/bar in touch mode operation. Due to the large signal, problems with parasitic capacitances are avoided and hence it is possible to integrate the sensor...... with a discrete components electronics circuit for signal conditioning. Using an AC bridge electronics circuit a resolution of 8 mV/mbar is achieved. The large signal is obtained due to a novel membrane structure utilizing closely packed hexagonal elements. The sensor is fabricated in a process based on fusion...

  5. Creating geometrically robust designs for highly sensitive problems using topology optimization: Acoustic cavity design

    DEFF Research Database (Denmark)

    Christiansen, Rasmus E.; Lazarov, Boyan S.; Jensen, Jakob S.

    2015-01-01

    Resonance and wave-propagation problems are known to be highly sensitive towards parameter variations. This paper discusses topology optimization formulations for creating designs that perform robustly under spatial variations for acoustic cavity problems. For several structural problems, robust...... and limitations are discussed. In addition, a known explicit penalization approach is considered for comparison. For near-uniform spatial variations it is shown that highly robust designs can be obtained using the double filter approach. It is finally demonstrated that taking non-uniform variations into account...... further improves the robustness of the designs....

  6. Tunnel Josephson junction as high-sensitive comparators in stroboscopic converters

    International Nuclear Information System (INIS)

    Askerzade, I.N.

    2000-01-01

    Paper presents the results of numerical simulation of dynamics of switching to the resistive state of several different type comparators based on the tunnel Josephson junctions within wide variation of their parameters. Particular attention was given to the design of comparator with the Faris generator. One determined dependences of comparator efficient operation on the circuit parameters. One demonstrated the application advisability of the balance comparator design under single-quanta pulses. The balance principle to design a comparator ensures better time resolution and high sensitivity as hysteresis of volt-ampere characteristic decreases [ru

  7. Diagnosis of acute myocardial infarction in patients with renal insufficiency using high-sensitivity troponin T.

    Science.gov (United States)

    Huang, Hualan; Zhu, Shuai; Wang, Weiqing; Yi, Hong; Du, Xiangyang; Nie, Xin; He, Yong; Song, Haolan; Miao, Qiang; Wang, Lanlan; Li, Guixing

    2015-04-01

    The objective of this study was to examine the diagnostic accuracy of high-sensitivity cardiac troponin T (hs-cTnT) for acute myocardial infarction (AMI) in patients with renal insufficiency, since this population has a high incidence of non-AMI elevations of hs-cTnT. In this prospective study, we enrolled 2249 consecutive patients presenting with chest pain in the emergency department (ED), of whom 19.5% had an estimated glomerular filtration rate (eGFR)cys of renal function [eGFRcys, r=-0.43 (-0.48, -0.38), prenal insufficiency.

  8. Thyroglobulin measurement using highly sensitive assays in patients with differentiated thyroid cancer:

    DEFF Research Database (Denmark)

    Giovanella, Luca; Clark, Penelope M; Chiovato, Luca

    2014-01-01

    Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence has increased in recent decades. Initial treatment usually consists of total thyroidectomy followed by ablation of thyroid remnants by iodine-131. As thyroid cells are assumed to be the only source...... at low concentrations now allows detection of very low Tg concentrations reflecting minimal amounts of thyroid tissue without the need for TSH stimulation. Use of these highly sensitive Tg assays has not yet been incorporated into clinical guidelines but they will, we believe, be used by physicians...

  9. Unfulfilled translation opportunities in industry sponsored clinical trials.

    Science.gov (United States)

    Smed, Marie; Getz, Kenneth A

    2013-05-01

    Knowledge generated by site representatives through their participation in clinical trials is valuable for testing new products in use and obtaining final market approval. The leverage of this important knowledge is however challenged as the former direct relationships between in-house staff in the industry and site representatives are changing. The process of clinical trials has increased in complexity over the years, resulting in additional management layers. Besides an increase in internal management layers, sponsors often also outsource various tasks related to clinical trials to a CRO (Contract Research Organization) and thereby adding another link in the relationships between site and sponsor. These changes are intended to optimize the time-consuming and costly trial phases; however, there is a need to study whether valuable knowledge and experience is compromised in the process. Limited research exists on the full range of clinical practice insights obtained by investigators during and after clinical trials and how well these insights are transferred to study sponsors. This study explores the important knowledge-transfer processes between sites and sponsors and to what extent sites' knowledge gained in clinical trials is utilized by the industry. Responses from 451 global investigative site representatives are included in the study. The analysis of the extensive dataset reveals that the current processes of collaboration between sites and the industry restrict the leverage of valuable knowledge gained by physicians in the process of clinical trials. These restrictions to knowledge-transfer between site and sponsor are further challenged if CRO partners are integrated in the trial process. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Handbook of unmanned aerial vehicles

    CERN Document Server

    Vachtsevanos, George

    2015-01-01

    The Handbook of Unmanned Aerial Vehicles is a reference text for the academic and research communities, industry, manufacturers, users, practitioners, Federal Government, Federal and State Agencies, the private sector, as well as all organizations that are and will be using unmanned aircraft in a wide spectrum of applications. The Handbook covers all aspects of UAVs, from design to logistics and ethical issues. It is also targeting the young investigator, the future inventor and entrepreneur by providing an overview and detailed information of the state-of-the-art as well as useful new concepts that may lead to innovative research. The contents of the Handbook include material that addresses the needs and ‘know how’ of all of the above sectors targeting a very diverse audience. The Handbook offers a unique and comprehensive treatise of everything one needs to know about unmanned aircrafts, from conception to operation, from technologies to business activities, users, OEMs, reference sources, conferences, ...

  11. Bespilotne letjelice : Unmanned aerial vehicles

    Directory of Open Access Journals (Sweden)

    Vlado Jurić

    2016-12-01

    Full Text Available Bespilotne letjelice imaju širok spektar uporabe, i svrha im svakim danom sve više dobiva na značaju. Konstrukcija im se poboljšava, pronalaze se materijali koji su optimalniji za obavljanje funkcija s kojima se trebaju suočiti. Pravna regulativa za bespilotne letjelice do 150 kg težine na polijetanju (MTOW se razlikuje od države do države. : Unmanned aerial vehicles have a wide range of applications, and their purpose is every day more important. Construction has been improving, finding the materials that are optimal for carrying out the functions which need to be cope with. Legal regulations for unmanned aircrafts up to 150 kg take-off weight (MTOW varies from country to country.

  12. MEMS Based Micro Aerial Vehicles

    Science.gov (United States)

    Joshi, Niranjan; Köhler, Elof; Enoksson, Peter

    2016-10-01

    Designing a flapping wing insect robot requires understanding of insect flight mechanisms, wing kinematics and aerodynamic forces. These subsystems are interconnected and their dependence on one another affects the overall performance. Additionally it requires an artificial muscle like actuator and transmission to power the wings. Several kinds of actuators and mechanisms are candidates for this application with their own strengths and weaknesses. This article provides an overview of the insect scaled flight mechanism along with discussion of various methods to achieve the Micro Aerial Vehicle (MAV) flight. Ongoing projects in Chalmers is aimed at developing a low cost and low manufacturing time MAV. The MAV design considerations and design specifications are mentioned. The wings are manufactured using 3D printed carbon fiber and are under experimental study.

  13. Marker Detection in Aerial Images

    KAUST Repository

    Alharbi, Yazeed

    2017-04-09

    The problem that the thesis is trying to solve is the detection of small markers in high-resolution aerial images. Given a high-resolution image, the goal is to return the pixel coordinates corresponding to the center of the marker in the image. The marker has the shape of two triangles sharing a vertex in the middle, and it occupies no more than 0.01% of the image size. An improvement on the Histogram of Oriented Gradients (HOG) is proposed, eliminating the majority of baseline HOG false positives for marker detection. The improvement is guided by the observation that standard HOG description struggles to separate markers from negatives patches containing an X shape. The proposed method alters intensities with the aim of altering gradients. The intensity-dependent gradient alteration leads to more separation between filled and unfilled shapes. The improvement is used in a two-stage algorithm to achieve high recall and high precision in detection of markers in aerial images. In the first stage, two classifiers are used: one to quickly eliminate most of the uninteresting parts of the image, and one to carefully select the marker among the remaining interesting regions. Interesting regions are selected by scanning the image with a fast classifier trained on the HOG features of markers in all rotations and scales. The next classifier is more precise and uses our method to eliminate the majority of the false positives of standard HOG. In the second stage, detected markers are tracked forward and backward in time. Tracking is needed to detect extremely blurred or distorted markers that are missed by the previous stage. The algorithm achieves 94% recall with minimal user guidance. An average of 30 guesses are given per image; the user verifies for each whether it is a marker or not. The brute force approach would return 100,000 guesses per image.

  14. Aerial shaking performance of wet Anna's hummingbirds

    Science.gov (United States)

    Ortega-Jimenez, Victor Manuel; Dudley, Robert

    2012-01-01

    External wetting poses problems of immediate heat loss and long-term pathogen growth for vertebrates. Beyond these risks, the locomotor ability of smaller animals, and particularly of fliers, may be impaired by water adhering to the body. Here, we report on the remarkable ability of hummingbirds to perform rapid shakes in order to expel water from their plumage even while in flight. Kinematic performance of aerial versus non-aerial shakes (i.e. those performed while perching) was compared. Oscillation frequencies of the head, body and tail were lower in aerial shakes. Tangential speeds and accelerations of the trunk and tail were roughly similar in aerial and non-aerial shakes, but values for head motions in air were twice as high when compared with shakes while perching. Azimuthal angular amplitudes for both aerial and non-aerial shakes reached values greater than 180° for the head, greater than 45° for the body trunk and slightly greater than 90° for the tail and wings. Using a feather on an oscillating disc to mimic shaking motions, we found that bending increased average speeds by up to 36 per cent and accelerations of the feather tip up to fourfold relative to a hypothetical rigid feather. Feather flexibility may help to enhance shedding of water and reduce body oscillations during shaking. PMID:22072447

  15. Optical fiber sensor based on capillary wall for highly-sensitive refractive index measurement

    Science.gov (United States)

    Liu, Yun; Peng, Wei; Zhang, Xinpu; Qian, Siyu

    2014-05-01

    This paper reports a temperature-compensated fiber-optic refractive index (RI) sensor for high sensitivity measurement. The sensor includes a piece of fused-silica capillary (FSC) and a fiber Bragg grating (FBG), both of which are sandwiched by single-mode fibers (SMFs). When light from the lead-in SMF enters into the wall of the FSC that acts as a RI sensing element, multiple modes are excited and interfere to form fringes collected by the lead-out SMF. The FBG is fabricated adjunct to the FSC to compensate its temperature sensitivity. The FSC based sensor prototype is fabricated and sealed in a flow cell to test its performance. Experimental results show that the sensor is highly sensitive to RI, and the sensitivity in the tested RI range from 1.33 to 1.35 is 698.52 nm/RIU and from 1.35 to 1.37 is 1061.78 nm/RIU. The temperature sensitivity of the FSC is -0.173 nm/°C, which is compensated by the FBG. This capillary wall based sensor can be further developed as a miniaturized fiber optic biosensor for biochemical application.

  16. Highly sensitive curvature sensor based on asymmetrical twin core fiber and multimode fiber

    Science.gov (United States)

    Wu, Yue; Pei, Li; Jin, Wenxing; Jiang, Youchao; Yang, Yuguang; Shen, Ya; Jian, Shuisheng

    2017-07-01

    A highly sensitive curvature sensor based on asymmetrical twin core fiber (TCF) and multimode fiber (MMF) is proposed and experimentally demonstrated. By applying the coupled-mode theory and equivalent refractive index model, we theoretically analyze the uncoupled feature of the TCF and the relationship between peak wavelength and the curvature. Two segments of MMF used as beam splitter and combiner are embedded on the two ends of the TCF, and the extinction ratio of the comb transmission spectrum is about 15 dB. The experimental result shows that the curvature sensitivity of the sensor can be achieved as high as 103.35 nm/m-1 ranging from 0.24 m-1 to 0.6 m-1, and the strain sensitivity is up to -4.01 pm/με in the range from 0 μεto 1400 με. The simultaneous detection of the curvature and strain can be realized. The temperature sensitivity is 0.431 nm/°C in the range from 40 °C to 70 °C. This fiber sensor exhibits the advantages of low cost, easy and repeated fabrication, and high sensitivity.

  17. Incorporation of beams into bossed diaphragm for a high sensitivity and overload micro pressure sensor.

    Science.gov (United States)

    Yu, Zhongliang; Zhao, Yulong; Sun, Lu; Tian, Bian; Jiang, Zhuangde

    2013-01-01

    The paper presents a piezoresistive absolute micro pressure sensor, which is of great benefits for altitude location. In this investigation, the design, fabrication, and test of the sensor are involved. By analyzing the stress distribution of sensitive elements using finite element method, a novel structure through the introduction of sensitive beams into traditional bossed diaphragm is built up. The proposed configuration presents its advantages in terms of high sensitivity and high overload resistance compared with the conventional bossed diaphragm and flat diaphragm structures. Curve fittings of surface stress and deflection based on ANSYS simulation results are performed to establish the equations about the sensor. Nonlinear optimization by MATLAB is carried out to determine the structure dimensions. The output signals in both static and dynamic environments are evaluated. Silicon bulk micromachining technology is utilized to fabricate the sensor prototype, and the fabrication process is discussed. Experimental results demonstrate the sensor features a high sensitivity of 11.098 μV/V/Pa in the operating range of 500 Pa at room temperature, and a high overload resistance of 200 times overpressure to promise its survival under atmosphere. Due to the excellent performance above, the sensor can be applied in measuring the absolute micro pressure lower than 500 Pa.

  18. Highly sensitive surface enhanced Raman scattering substrates based on filter paper loaded with plasmonic nanostructures.

    Science.gov (United States)

    Lee, Chang H; Hankus, Mikella E; Tian, Limei; Pellegrino, Paul M; Singamaneni, Srikanth

    2011-12-01

    We report a novel surface enhanced Raman scattering (SERS) substrate platform based on a common filter paper adsorbed with plasmonic nanostructures that overcomes many of the challenges associated with existing SERS substrates. The paper-based design results in a substrate that combines all of the advantages of conventional rigid and planar SERS substrates in a dynamic flexible scaffolding format. In this paper, we discuss the fabrication, physical characterization, and SERS activity of our novel substrates using nonresonant analytes. The SERS substrate was found to be highly sensitive, robust, and amiable to several different environments and target analytes. It is also cost-efficient and demonstrates high sample collection efficiency and does not require complex fabrication methodologies. The paper substrate has high sensitivity (0.5 nM trans-1,2-bis(4-pyridyl)ethene (BPE)) and excellent reproducibility (~15% relative standard deviation (RSD)). The paper substrates demonstrated here establish a novel platform for integrating SERS with already existing analytical techniques such as chromatography and microfluidics, imparting chemical specificity to these techniques.

  19. A high sensitivity field effect transistor biosensor for methylene blue detection utilize graphene oxide nanoribbon.

    Science.gov (United States)

    Lin, Ting-Chun; Li, Yan-Sheng; Chiang, Wei-Hung; Pei, Zingway

    2017-03-15

    In this work, we developed a field effect transistor (FET) biosensor utilizing solution-processed graphene oxide nanoribbon (GONR) for methylene blue (MB) sensing. MB is a unique material; one of its crucial applications is as a marker in the detection of biomaterials. Therefore, a highly sensitive biosensor with a low detection limit that can be fabricated simply in a noncomplex detection scheme is desirable. GONR is made by unzipping multiwall carbon nanotubes, which can be mass-produced at low temperature. The GONR-FET biosensor demonstrated a sensitivity of 12.5μA/mM (determined according to the drain current difference caused by the MB concentration change). The Raman spectra indicate that the materials quality of the GONR and the domain size for the C=C sp 2 bonding were both improved after MB detection. X-ray photoelectron spectroscopy revealed that the hydroxyl groups on the GONR were removed by the reductive MB. According to XPS and Raman, the positive charge is proposed to transfer from MB to GONR during sensing. This transfer causes charge in-neutrality in the GONR which is compensated by releasing •OH functional groups. With high sensitivity, a low detection limit, and a simple device structure, the GONR-FET sensor is suitable for sensing biomaterials. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. High-performance and high-sensitivity applications of graphene transistors with self-assembled monolayers.

    Science.gov (United States)

    Yeh, Chao-Hui; Kumar, Vinod; Moyano, David Ricardo; Wen, Shao-Hsuan; Parashar, Vyom; Hsiao, She-Hsin; Srivastava, Anchal; Saxena, Preeti S; Huang, Kun-Ping; Chang, Chien-Chung; Chiu, Po-Wen

    2016-03-15

    Charge impurities and polar molecules on the surface of dielectric substrates has long been a critical obstacle to using graphene for its niche applications that involve graphene's high mobility and high sensitivity nature. Self-assembled monolayers (SAMs) have been found to effectively reduce the impact of long-range scatterings induced by the external charges. Yet, demonstrations of scalable device applications using the SAMs technique remains missing due to the difficulties in the device fabrication arising from the strong surface tension of the modified dielectric environment. Here, we use patterned SAM arrays to build graphene electronic devices with transport channels confined on the modified areas. For high-mobility applications, both rigid and flexible radio-frequency graphene field-effect transistors (G-FETs) were demonstrated, with extrinsic cutoff frequency and maximum oscillation frequency enhanced by a factor of ~2 on SiO2/Si substrates. For high sensitivity applications, G-FETs were functionalized by monoclonal antibodies specific to cancer biomarker chondroitin sulfate proteoglycan 4, enabling its detection at a concentration of 0.01 fM, five orders of magnitude lower than that detectable by a conventional colorimetric assay. These devices can be very useful in the early diagnosis and monitoring of a malignant disease. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Evaluation of serum homocysteine, high-sensitivity CRP, and RBC folate in patients with alopecia areata

    Directory of Open Access Journals (Sweden)

    Maryam Yousefi

    2014-01-01

    Full Text Available Introduction: Alopecia areata (AA is a common type of hair loss with an autoimmune basis. As the role of homocysteine (Hcys, folate, and CRP has been considered in some autoimmune diseases. Objectives: To evaluate homocysteine, folate and CRP level in AA. Methods: This study was performed on 29 patients who had AA for at least 6 months affecting more than 20% of scalp, and 32 healthy controls. Levels of serum Hcys, blood high-sensitivity CRP, and RBC folate were measured in all subjects. Results: The mean level of RBC folate was significantly lower in the patient group than that in controls (P < 0.001. Also, the level of RBC folate was significantly lower in patients with extensive forms of disease (alopecia totalis/alopecia universalis in comparison with more localized form (patchy hair loss (P < 0.05. Patients with higher "Severity of Alopecia Total" (SALT score had lower RBC folate, as well. Serum Hcys and blood high-sensitivity CRP levels did not show a significant difference in two groups. Conclusion: Patients with alopecia areata have lower level of RBC folate which is in negative correlation with both severity and extension of AA.

  2. Development of a High-Sensitivity Wireless Accelerometer for Structural Health Monitoring

    Science.gov (United States)

    Zhu, Li; Fu, Yuguang; Chow, Raymond; Spencer, Billie F.; Park, Jong Woong; Mechitov, Kirill

    2018-01-01

    Structural health monitoring (SHM) is playing an increasingly important role in ensuring the safety of structures. A shift of SHM research away from traditional wired methods toward the use of wireless smart sensors (WSS) has been motivated by the attractive features of wireless smart sensor networks (WSSN). The progress achieved in Micro Electro-Mechanical System (MEMS) technologies and wireless data transmission, has extended the effectiveness and range of applicability of WSSNs. One of the most common sensors employed in SHM strategies is the accelerometer; however, most accelerometers in WSS nodes have inadequate resolution for measurement of the typical accelerations found in many SHM applications. In this study, a high-resolution and low-noise tri-axial digital MEMS accelerometer is incorporated in a next-generation WSS platform, the Xnode. In addition to meeting the acceleration sensing demands of large-scale civil infrastructure applications, this new WSS node provides powerful hardware and a robust software framework to enable edge computing that can deliver actionable information. Hardware and software integration challenges are presented, and the associate resolutions are discussed. The performance of the wireless accelerometer is demonstrated experimentally through comparison with high-sensitivity wired accelerometers. This new high-sensitivity wireless accelerometer will extend the use of WSSN to a broader class of SHM applications. PMID:29342102

  3. Development of a High-Sensitivity Wireless Accelerometer for Structural Health Monitoring.

    Science.gov (United States)

    Zhu, Li; Fu, Yuguang; Chow, Raymond; Spencer, Billie F; Park, Jong Woong; Mechitov, Kirill

    2018-01-17

    Structural health monitoring (SHM) is playing an increasingly important role in ensuring the safety of structures. A shift of SHM research away from traditional wired methods toward the use of wireless smart sensors (WSS) has been motivated by the attractive features of wireless smart sensor networks (WSSN). The progress achieved in Micro Electro-Mechanical System (MEMS) technologies and wireless data transmission, has extended the effectiveness and range of applicability of WSSNs. One of the most common sensors employed in SHM strategies is the accelerometer; however, most accelerometers in WSS nodes have inadequate resolution for measurement of the typical accelerations found in many SHM applications. In this study, a high-resolution and low-noise tri-axial digital MEMS accelerometer is incorporated in a next-generation WSS platform, the Xnode. In addition to meeting the acceleration sensing demands of large-scale civil infrastructure applications, this new WSS node provides powerful hardware and a robust software framework to enable edge computing that can deliver actionable information. Hardware and software integration challenges are presented, and the associate resolutions are discussed. The performance of the wireless accelerometer is demonstrated experimentally through comparison with high-sensitivity wired accelerometers. This new high-sensitivity wireless accelerometer will extend the use of WSSN to a broader class of SHM applications.

  4. Gold nanoparticle-based exonuclease III signal amplification for highly sensitive colorimetric detection of folate receptor

    Science.gov (United States)

    Yang, Xinjian; Gao, Zhiqiang

    2014-02-01

    By combining terminal protection of small molecule (folate)-capped DNA probes, exonuclease III signal amplification and gold nanoparticles, we developed a simple and label-free colorimetric assay for highly sensitive detection of folate receptor (FR). A detection limit of 50 fM FR was obtained using UV-vis spectrometry and 10 pM FR could be visualized by the naked eye.By combining terminal protection of small molecule (folate)-capped DNA probes, exonuclease III signal amplification and gold nanoparticles, we developed a simple and label-free colorimetric assay for highly sensitive detection of folate receptor (FR). A detection limit of 50 fM FR was obtained using UV-vis spectrometry and 10 pM FR could be visualized by the naked eye. Electronic supplementary information (ESI) available: Experimental details, salt and DNA-2 effects on the stability of the AuNP solution. See DOI: 10.1039/c3nr06139f

  5. Highly sensitive and selective sugar detection by terahertz nano-antennas

    Science.gov (United States)

    Lee, Dong-Kyu; Kang, Ji-Hun; Lee, Jun-Seok; Kim, Hyo-Seok; Kim, Chulki; Hun Kim, Jae; Lee, Taikjin; Son, Joo-Hiuk; Park, Q.-Han; Seo, Minah

    2015-10-01

    Molecular recognition and discrimination of carbohydrates are important because carbohydrates perform essential roles in most living organisms for energy metabolism and cell-to-cell communication. Nevertheless, it is difficult to identify or distinguish various carbohydrate molecules owing to the lack of a significant distinction in the physical or chemical characteristics. Although there has been considerable effort to develop a sensing platform for individual carbohydrates selectively using chemical receptors or an ensemble array, their detection and discrimination limits have been as high in the millimolar concentration range. Here we show a highly sensitive and selective detection method for the discrimination of carbohydrate molecules using nano-slot-antenna array-based sensing chips which operate in the terahertz (THz) frequency range (0.5-2.5 THz). This THz metamaterial sensing tool recognizes various types of carbohydrate molecules over a wide range of molecular concentrations. Strongly localized and enhanced terahertz transmission by nano-antennas can effectively increase the molecular absorption cross sections, thereby enabling the detection of these molecules even at low concentrations. We verified the performance of nano-antenna sensing chip by both THz spectra and images of transmittance. Screening and identification of various carbohydrates can be applied to test even real market beverages with a high sensitivity and selectivity.

  6. Ultra-high sensitivity photodetector arrays with integrated amplification and passivation nano-layers

    Science.gov (United States)

    Yao, Jie; Wang, Sean; Zhou, Jack; Li, Ken; Lange, Michael; Yang, Weiguo; Gardner, Patrick; Peltz, Leora; Frampton, Robert; Hunt, Jeffrey H.; Becker, Jill

    2009-02-01

    Miniaturized field-deployable spectrometers used for rapid analysis of chemical and biological substances require high-sensitivity photo detectors. For example, in a Raman spectroscopy system, the receiver must be capable of high-gain, low-noise detection performance due to the intrinsically weak signals produced by the Raman effects of most substances. We are developing a novel, high-gain hetero-junction phototransistor (HPT) detector which employs two nano-structures simultaneously: a 3-30 nm passivation layer that enables micron-sized devices, large-scale integration and low-cost products; and a 50-65 nm amplification layer that offers high sensitivity with 1,000x amplification and zero avalanche access noise. We report preliminary tests on single pixels, validating the design target of >1,000 Ampere/Watt responsivity at the near infrared wavelength of 1550nm, which is 100 times more sensitive than InGaAs avalanche photodiodes, the most sensitive commercially available photo-detector in this wavelength range, under their normal operation conditions. Integrated into a detector array, this technology has application for Laser-Induced Breakdown Spectroscopy (LIBS), pollution monitoring, pharmaceutical manufacturing by reaction monitoring, chemical & biological transportation safety, and bio-chemical analysis in planetary exploration.

  7. Application of graphene for preconcentration and highly sensitive stripping voltammetric analysis of organophosphate pesticide

    Energy Technology Data Exchange (ETDEWEB)

    Wu Shuo, E-mail: wushuo@dlut.edu.cn [School of Chemistry, Dalian University of Technology, Dalian 116023 (China); Lan Xiaoqin; Cui Lijun; Zhang Lihui; Tao Shengyang; Wang Hainan; Han Mei; Liu Zhiguang; Meng Changgong [School of Chemistry, Dalian University of Technology, Dalian 116023 (China)

    2011-08-12

    Highlights: {yields} An electrochemical sensor is fabricated based on {beta}-CD dispersed graphene. {yields} The sensor could selectively detect organophosphate pesticide with high sensitivity. {yields} The {beta}-CD dispersed graphene owns large adsorption capacity for MP and superconductivity. {yields} The {beta}-CD dispersed graphene is superior to most of the porous sorbents ever known. - Abstract: Electrochemical reduced {beta}-cyclodextrin dispersed graphene ({beta}-CD-graphene) was developed as a sorbent for the preconcentration and electrochemical sensing of methyl parathion (MP), a representative nitroaromatic organophosphate pesticide with good redox activity. Benefited from the ultra-large surface area, large delocalized {pi}-electron system and the superconductivity of {beta}-CD-graphene, large amount of MP could be extracted on {beta}-CD-graphene modified electrode via strong {pi}-{pi} interaction and exhibited fast accumulation and electron transfer rate. Combined with differential pulse voltammetric analysis, the sensor shows ultra-high sensitivity, good selectivity and fast response. The limit of detection of 0.05 ppb is more than 10 times lower than those obtained from other sorbent based sensors. The method may open up a new possibility for the widespread use of electrochemical sensors for monitoring of ultra-trace OPs.

  8. Application of graphene for preconcentration and highly sensitive stripping voltammetric analysis of organophosphate pesticide

    International Nuclear Information System (INIS)

    Wu Shuo; Lan Xiaoqin; Cui Lijun; Zhang Lihui; Tao Shengyang; Wang Hainan; Han Mei; Liu Zhiguang; Meng Changgong

    2011-01-01

    Highlights: → An electrochemical sensor is fabricated based on β-CD dispersed graphene. → The sensor could selectively detect organophosphate pesticide with high sensitivity. → The β-CD dispersed graphene owns large adsorption capacity for MP and superconductivity. → The β-CD dispersed graphene is superior to most of the porous sorbents ever known. - Abstract: Electrochemical reduced β-cyclodextrin dispersed graphene (β-CD-graphene) was developed as a sorbent for the preconcentration and electrochemical sensing of methyl parathion (MP), a representative nitroaromatic organophosphate pesticide with good redox activity. Benefited from the ultra-large surface area, large delocalized π-electron system and the superconductivity of β-CD-graphene, large amount of MP could be extracted on β-CD-graphene modified electrode via strong π-π interaction and exhibited fast accumulation and electron transfer rate. Combined with differential pulse voltammetric analysis, the sensor shows ultra-high sensitivity, good selectivity and fast response. The limit of detection of 0.05 ppb is more than 10 times lower than those obtained from other sorbent based sensors. The method may open up a new possibility for the widespread use of electrochemical sensors for monitoring of ultra-trace OPs.

  9. Highly Sensitive Flexible Pressure Sensor Based on Silver Nanowires-Embedded Polydimethylsiloxane Electrode with Microarray Structure.

    Science.gov (United States)

    Shuai, Xingtian; Zhu, Pengli; Zeng, Wenjin; Hu, Yougen; Liang, Xianwen; Zhang, Yu; Sun, Rong; Wong, Ching-Ping

    2017-08-09

    Flexible pressure sensors have attracted increasing research interest because of their potential applications for wearable sensing devices. Herein, a highly sensitive flexible pressure sensor is exhibited based on the elastomeric electrodes and a microarray architecture. Polydimethylsiloxane (PDMS) substrate, coated with silver nanowires (AgNWs), is used as the top electrode, while polyvinylidene fluoride (PVDF) as the dielectric layer. Several transfer processes are applied on seeking facile strategy for the preparation of the bottom electrode via embedding AgNWs into the PDMS film of microarray structure. The flexible pressure sensor integrates the top electrode, dielectric layer, and microarray electrode in a sandwich structure. It is demonstrated that such sensors possess the superiorities of high sensitivity (2.94 kPa -1 ), low detection limit (flexible pressure sensor exhibits good performance even in a noncontact way, such as detecting voice vibrations and air flow. Due to its superior performance, this designed flexible pressure sensor demonstrates promising potential in the application of electronic skins, as well as wearable healthcare monitors.

  10. A Flexible and Highly Sensitive Pressure Sensor Based on a PDMS Foam Coated with Graphene Nanoplatelets

    Directory of Open Access Journals (Sweden)

    Andrea Rinaldi

    2016-12-01

    Full Text Available The demand for high performance multifunctional wearable devices is more and more pushing towards the development of novel low-cost, soft and flexible sensors with high sensitivity. In the present work, we describe the fabrication process and the properties of new polydimethylsiloxane (PDMS foams loaded with multilayer graphene nanoplatelets (MLGs for application as high sensitive piezoresistive pressure sensors. The effective DC conductivity of the produced foams is measured as a function of MLG loading. The piezoresistive response of the MLG-PDMS foam-based sensor at different strain rates is assessed through quasi-static pressure tests. The results of the experimental investigations demonstrated that sensor loaded with 0.96 wt.% of MLGs is characterized by a highly repeatable pressure-dependent conductance after a few stabilization cycles and it is suitable for detecting compressive stresses as low as 10 kPa, with a sensitivity of 0.23 kPa−1, corresponding to an applied pressure of 70 kPa. Moreover, it is estimated that the sensor is able to detect pressure variations of ~1 Pa. Therefore, the new graphene-PDMS composite foam is a lightweight cost-effective material, suitable for sensing applications in the subtle or low and medium pressure ranges.

  11. Highly sensitive polymerase chain reaction-free quantum dot-based quantification of forensic genomic DNA

    International Nuclear Information System (INIS)

    Tak, Yu Kyung; Kim, Won Young; Kim, Min Jung; Han, Eunyoung; Han, Myun Soo; Kim, Jong Jin; Kim, Wook; Lee, Jong Eun; Song, Joon Myong

    2012-01-01

    Highlights: ► Genomic DNA quantification were performed using a quantum dot-labeled Alu sequence. ► This probe provided PCR-free determination of human genomic DNA. ► Qdot-labeled Alu probe-hybridized genomic DNAs had a 2.5-femtogram detection limit. ► Qdot-labeled Alu sequence was used to assess DNA samples for human identification. - Abstract: Forensic DNA samples can degrade easily due to exposure to light and moisture at the crime scene. In addition, the amount of DNA acquired at a criminal site is inherently limited. This limited amount of human DNA has to be quantified accurately after the process of DNA extraction. The accurately quantified extracted genomic DNA is then used as a DNA template in polymerase chain reaction (PCR) amplification for short tandem repeat (STR) human identification. Accordingly, highly sensitive and human-specific quantification of forensic DNA samples is an essential issue in forensic study. In this work, a quantum dot (Qdot)-labeled Alu sequence was developed as a probe to simultaneously satisfy both the high sensitivity and human genome selectivity for quantification of forensic DNA samples. This probe provided PCR-free determination of human genomic DNA and had a 2.5-femtogram detection limit due to the strong emission and photostability of the Qdot. The Qdot-labeled Alu sequence has been used successfully to assess 18 different forensic DNA samples for STR human identification.

  12. A SERS-based lateral flow assay biosensor for highly sensitive detection of HIV-1 DNA.

    Science.gov (United States)

    Fu, Xiuli; Cheng, Ziyi; Yu, Jimin; Choo, Priscilla; Chen, Lingxin; Choo, Jaebum

    2016-04-15

    User-friendly lateral flow (LF) strips have been extensively used for point-of-care (POC) self-diagnostics, but they have some limitations in their detection sensitivity and quantitative analysis because they only identify the high cut-off value of a biomarker by utilizing color changes that are detected with the naked eye. To resolve these problems associated with LF strips, we developed a novel surface-enhanced Raman scattering (SERS)-based LF assay for the quantitative analysis of a specific biomarker in the low concentration range. Herein, human immunodeficiency virus type 1 (HIV-1) DNA was chosen as the specific biomarker. Raman reporter-labeled gold nanoparticles (AuNPs) were employed as SERS nano tags for targeting and detecting the HIV-1 DNA marker, as opposed to using bare AuNPs in LF strips. It was possible to quantitatively analyze HIV-1 DNA with high sensitivity by monitoring the characteristic Raman peak intensity of the DNA-conjugated AuNPs. Under optimized conditions, the detection limit of our SERS-based lateral flow assay was 0.24 pg/mL, which was at least 1000 times more sensitive compared to colorimetric or fluorescent detection methods. These results demonstrate the potential feasibility of the proposed SERS-based lateral flow assay to quantitatively detect a broad range of genetic diseases with high sensitivity. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Symmetry-Breaking as a Paradigm to Design Highly-Sensitive Sensor Systems

    Directory of Open Access Journals (Sweden)

    Antonio Palacios

    2015-06-01

    Full Text Available A large class of dynamic sensors have nonlinear input-output characteristics, often corresponding to a bistable potential energy function that controls the evolution of the sensor dynamics. These sensors include magnetic field sensors, e.g., the simple fluxgate magnetometer and the superconducting quantum interference device (SQUID, ferroelectric sensors and mechanical sensors, e.g., acoustic transducers, made with piezoelectric materials. Recently, the possibilities offered by new technologies and materials in realizing miniaturized devices with improved performance have led to renewed interest in a new generation of inexpensive, compact and low-power fluxgate magnetometers and electric-field sensors. In this article, we review the analysis of an alternative approach: a symmetry-based design for highly-sensitive sensor systems. The design incorporates a network architecture that produces collective oscillations induced by the coupling topology, i.e., which sensors are coupled to each other. Under certain symmetry groups, the oscillations in the network emerge via an infinite-period bifurcation, so that at birth, they exhibit a very large period of oscillation. This characteristic renders the oscillatory wave highly sensitive to symmetry-breaking effects, thus leading to a new detection mechanism. Model equations and bifurcation analysis are discussed in great detail. Results from experimental works on networks of fluxgate magnetometers are also included.

  14. Nonindustry-sponsored preclinical studies on statins yield greater efficacy estimates than industry-sponsored studies: a meta-analysis.

    Science.gov (United States)

    Krauth, David; Anglemyer, Andrew; Philipps, Rose; Bero, Lisa

    2014-01-01

    Industry-sponsored clinical drug studies are associated with publication of outcomes that favor the sponsor, even when controlling for potential bias in the methods used. However, the influence of sponsorship bias has not been examined in preclinical animal studies. We performed a meta-analysis of preclinical statin studies to determine whether industry sponsorship is associated with either increased effect sizes of efficacy outcomes and/or risks of bias in a cohort of published preclinical statin studies. We searched Medline (January 1966-April 2012) and identified 63 studies evaluating the effects of statins on atherosclerosis outcomes in animals. Two coders independently extracted study design criteria aimed at reducing bias, results for all relevant outcomes, sponsorship source, and investigator financial ties. The I(2) statistic was used to examine heterogeneity. We calculated the standardized mean difference (SMD) for each outcome and pooled data across studies to estimate the pooled average SMD using random effects models. In a priori subgroup analyses, we assessed statin efficacy by outcome measured, sponsorship source, presence or absence of financial conflict information, use of an optimal time window for outcome assessment, accounting for all animals, inclusion criteria, blinding, and randomization. The effect of statins was significantly larger for studies sponsored by nonindustry sources (-1.99; 95% CI -2.68, -1.31) versus studies sponsored by industry (-0.73; 95% CI -1.00, -0.47) (p valuefinancial conflict information, use of an optimal time window for outcome assessment, accounting for all animals, inclusion criteria, blinding, and randomization. Possible reasons for the differences between nonindustry- and industry-sponsored studies, such as selective reporting of outcomes, require further study.

  15. ARM Aerial Facility ArcticShark Unmanned Aerial System

    Science.gov (United States)

    Schmid, B.; Hubbell, M.; Mei, F.; Carroll, P.; Mendoza, A.; Ireland, C.; Lewko, K.

    2017-12-01

    The TigerShark Block 3 XP-AR "ArcticShark" Unmanned Aerial System (UAS), developed and manufactured by Navmar Applied Sciences Corporation (NASC), is a single-prop, 60 hp rotary-engine platform with a wingspan of 6.5 m and Maximum Gross Takeoff Weight of 295 Kg. The ArcticShark is owned by the U.S. Department of Energy (DOE) and has been operated by Pacific Northwest National Laboratory (PNNL) since March 2017. The UAS will serve as an airborne atmospheric research observatory for DOE ARM, and, once fully operational, can be requested through ARM's annual call for proposals. The Arctic Shark is anticipated to measure a wide range of radiative, aerosol, and cloud properties using a variable instrument payload weighing up to 46 Kg. SATCOM-equipped, it is capable of taking measurements up to altitudes of 5.5 Km over ranges of up to 500 Km. The ArcticShark operates at airspeeds of 30 to 40 m/s, making it capable of slow sampling. With a full fuel load, its endurance exceeds 8 hours. The aircraft and its Mobile Operations Center (MOC) have been hardened specifically for operations in colder temperatures.ArcticShark's design facilitates rapid integration of various types of payloads. 2500 W of its 4000 W electrical systems is dedicated to payload servicing. It has an interior payload volume of almost 85 L and four wing-mounted pylons capable of carrying external probes. Its payload bay volume, electrical power, payload capacity, and flight characteristics enable the ArcticShark to accommodate multiple combinations of payloads in numerous configurations. Many instruments will be provided by the ARM Aerial Facility (AAF), but other organizations may eventually propose instrumentation for specific campaigns. AAF-provided measurement capabilities will include the following atmospheric state and thermodynamics: temperature, pressure, winds; gases: H2O and CO2; up- and down-welling broadband infrared and visible radiation; surface temperature; aerosol number concentration

  16. 7 CFR 611.21 - Availability of aerial photography.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Availability of aerial photography. 611.21 Section 611... § 611.21 Availability of aerial photography. The National Cartography and Geospatial Center obtains necessary clearance for all aerial photography for NRCS. New aerial photography of designated areas in the...

  17. On a State-Sponsored Sport System in China.

    Science.gov (United States)

    Cao, Jie; Zhiwei, Pan

    The gold medal success of China in recent Olympic Games can be traced to the advancement of the state-sponsored sport system (SSSS). While the program was developed initially through socialist ideals, it is more than a centralized government system to monopolize resources for glorified sport performance. Participation in competition is an inherent part of the human condition. Success in athletics is associated with national identity and has economic, social, and cultural implications. Because of this, it is essential that the SSSS adjust and improve to keep pace with other facets of China's quickly changing national reform. In association with emerging economic reform, some sports now receive equal or more funds from private investments compared to government allocation. The state-sponsored sport system must continue to adapt to maintain the Chinese tradition of excellence in competition.

  18. Unfulfilled translation opportunities in industry sponsored clinical trials

    DEFF Research Database (Denmark)

    Smed, Marie; Getz, Kenneth A.

    2013-01-01

    Knowledge generated by site representatives through their participation in clinical trials is valuable for testing new products in use and obtaining final market approval. The leverage of this important knowledge is however challenged as the former direct relationships between in-house staff...... in the industry and site representatives are changing. The process of clinical trials has increased in complexity over the years, resulting in additional management layers. Besides an increase in internal management layers, sponsors often also outsource various tasks related to clinical trials to a CRO (Contract...... Research Organization) and thereby adding another link in the relationships between site and sponsor. These changes are intended to optimize the time-consuming and costly trial phases; however, there is a need to study whether valuable knowledge and experience is compromised in the process. Limited...

  19. Budget constraints and optimization in sponsored search auctions

    CERN Document Server

    Yang, Yanwu

    2013-01-01

    The Intelligent Systems Series publishes reference works and handbooks in three core sub-topic areas: Intelligent Automation, Intelligent Transportation Systems, and Intelligent Computing. They include theoretical studies, design methods, and real-world implementations and applications. The series' readership is broad, but focuses on engineering, electronics, and computer science. Budget constraints and optimization in sponsored search auctions takes into account consideration of the entire life cycle of campaigns for researchers and developers working on search systems and ROI maximization

  20. Searching for sponsors for four national rugby teams in Finland

    OpenAIRE

    Ylönen, Niina

    2017-01-01

    How to get more sponsors to four national rugby teams in Finland? Finnish Rugby Federation and its four national teams are in the need of new long lasting sponsorship deals to fund the national teams’ tournaments in Finland and abroad. Since rugby is quite unknown sports in Finland it faces challenges in getting new sponsorship deals and also its visibility is currently very low. The purpose of this thesis is to analyse the current situation of rugby, sponsorship contracts Finnish rugby F...

  1. First demonstration of aerial gamma-ray imaging using drone for prompt radiation survey in Fukushima

    Science.gov (United States)

    Mochizuki, S.; Kataoka, J.; Tagawa, L.; Iwamoto, Y.; Okochi, H.; Katsumi, N.; Kinno, S.; Arimoto, M.; Maruhashi, T.; Fujieda, K.; Kurihara, T.; Ohsuka, S.

    2017-11-01

    Considerable amounts of radioactive substances (mainly 137Cs and 134Cs) were released into the environment after the Japanese nuclear disaster in 2011. Some restrictions on residence areas were lifted in April 2017, owing to the successive and effective decontamination operations. However, the distribution of radioactive substances in vast areas of mountain, forest and satoyama close to the city is still unknown; thus, decontamination operations in such areas are being hampered. In this paper, we report on the first aerial gamma-ray imaging of a schoolyard in Fukushima using a drone that carries a high sensitivity Compton camera. We show that the distribution of 137Cs in regions with a diameter of several tens to a hundred meters can be imaged with a typical resolution of 2–5 m within a 10–20 min flights duration. The aerial gamma-ray images taken 10 m and 20 m above the ground are qualitatively consistent with a dose map reconstructed from the ground-based measurements using a survey meter. Although further quantification is needed for the distance and air-absorption corrections to derive in situ dose map, such an aerial drone system can reduce measurement time by a factor of ten and is suitable for place where ground-based measurement are difficult.

  2. Aerial view of the works at PGC

    CERN Multimedia

    CERN PhotoLab

    1973-01-01

    Aerial view of the works at PGC : in the foreground, the prefabrication of the concrete slabs. In the background, on the left the storage of the spoil, on the right the extraction tower mounted on PGC.

  3. MODELLING GROUP ACTION OF UNMANNED AERIAL VEHICLES

    Directory of Open Access Journals (Sweden)

    S. V. Korevanov

    2015-01-01

    Full Text Available The problems of modeling and planning group flights of unmanned aerial vehicles are considered. For each stage of the planning procedure of group activates neural network structure is designed.

  4. Persistent Aerial Tracking system for UAVs

    KAUST Repository

    Mueller, Matthias

    2016-12-19

    In this paper, we propose a persistent, robust and autonomous object tracking system for unmanned aerial vehicles (UAVs) called Persistent Aerial Tracking (PAT). A computer vision and control strategy is applied to a diverse set of moving objects (e.g. humans, animals, cars, boats, etc.) integrating multiple UAVs with a stabilized RGB camera. A novel strategy is employed to successfully track objects over a long period, by ‘handing over the camera’ from one UAV to another. We evaluate several state-of-the-art trackers on the VIVID aerial video dataset and additional sequences that are specifically tailored to low altitude UAV target tracking. Based on the evaluation, we select the leading tracker and improve upon it by optimizing for both speed and performance, integrate the complete system into an off-the-shelf UAV, and obtain promising results showing the robustness of our solution in real-world aerial scenarios.

  5. Douglas County Historical Rectified Aerial Photos 1954

    Data.gov (United States)

    Kansas Data Access and Support Center — This raster dataset consists of approximately 200 aerial photographs taken in 1954 in Douglas county, Kansas, United States. The Douglas County Public Works...

  6. Atlantic Protected Species Assessment Aerial Surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data sets include a compilation of aerial line-transect surveys conducted over continental shelf waters of the southeastern U.S. Surveys have been conducted...

  7. Dropsonde System for Unmanned Aerial Vehicles Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A small, modular dropsonde launcher is being developed for Unmanned Aerial Vehicles (UAVs). Some critical measurement needs can only be satisfied by in-situ...

  8. Acoustic Detection from Aerial Balloon Platform

    National Research Council Canada - National Science Library

    Reiff, C; Pham, T; Scanlon, M; Noble, J; Van Landuyt, A; Petek, J; Ratches, J

    2004-01-01

    ... such as unmanned aerial vehicles (UAVs) and balloons. Our most immediate collaboration focuses on the use of acoustic sensors on small balloons and/or aerostats at several elevations and on the ground with the primary goals...

  9. Douglas County Historical Rectified Aerial Photos 1937

    Data.gov (United States)

    Kansas Data Access and Support Center — This raster dataset consists of approximately 200 aerial photographs taken in 1937 in Douglas county, Kansas, United States. The Douglas County Public Works...

  10. Redactions in protocols for drug trials: what industry sponsors concealed.

    Science.gov (United States)

    Marquardsen, Mikkel; Ogden, Michelle; Gøtzsche, Peter C

    2018-01-01

    Objective To describe the redactions in contemporary protocols for industry-sponsored randomised drug trials with patient relevant outcomes and to evaluate whether there was a legitimate rationale for the redactions. Design Cohort study. Under the Freedom of Information Act, we requested access to trial protocols approved by a research ethics committee in Denmark from October 2012 to March 2013. We received 17 consecutive protocols, which had been redacted before we got them, and nine protocols without redactions. In five additional cases, the companies refused to let the committees give us access, and in three other cases, documents were missing. Participants Not applicable. Setting Not applicable. Main outcome measure Amount and nature of redactions in 22 predefined key protocol variables. Results The redactions were most widespread in those sections of the protocol where there is empirical evidence of substantial problems with the trustworthiness of published drug trials: data analysis, handling of missing data, detection and analysis of adverse events, definition of the outcomes, interim analyses and premature termination of the study, sponsor's access to incoming data while the study is running, ownership to the data and investigators' publication rights. The parts of the text that were redacted differed widely, both between companies and within the same company. Conclusions We could not identify any legitimate rationale for the redactions. The current mistrust in industry-sponsored drug trials can only change if the industry offers unconditional access to its trial protocols and other relevant documents and data.

  11. Biopharmaceutical industry-sponsored global clinical trials in emerging countries.

    Science.gov (United States)

    Alvarenga, Lenio Souza; Martins, Elisabeth Nogueira

    2010-01-01

    To evaluate biopharmaceutical industry-sponsored clinical trials placed in countries previously described as emerging regions for clinical research, and potential differences for those placed in Brazil. Data regarding recruitment of subjects for clinical trials were retrieved from www.clinicaltrials.gov on February 2nd 2009. Proportions of sites in each country were compared among emerging countries. Multiple logistic regressions were performed to evaluate whether trial placement in Brazil could be predicted by trial location in other countries and/or by trial features. A total of 8,501 trials were then active and 1,170 (13.8%) included sites in emerging countries (i.e., Argentina, Brazil, China, Czech Republic, Hungary, India, Mexico, Poland, Russia, South Korea, and South Africa). South Korea and China presented a significantly higher proportion of sites when compared to other countries (pBrazil. Trials involving subjects with less than 15 years of age, those with targeted recruitment of at least 1,000 subjects, and seven sponsors were identified as significant predictors of trial placement in Brazil. No clear direct competition between Brazil and other emerging countries was detected. South Korea showed the higher proportion of sites and ranked third in total number of trials, appearing as a major player in attractiveness for biopharmaceutical industry-sponsored clinical trials.

  12. A low-temperature high-sensitivity torsion balance magnetometer with in situ stator adjustment

    Science.gov (United States)

    Matthews, A. J.; Usher, A.; Williams, C. D. H.

    2004-08-01

    Torsion balance magnetometry can be used as a versatile probe of two-dimensional electron systems. We have developed a highly sensitive magnetometer, utilizing capacitive proximity detection of the rotor position, for use at temperatures below 10 mK. The instrument incorporates two piezo-electric linear motors to enable the stator positions to be adjusted in situ at base temperature. The magnetometer responsivity is inversely proportional to the square of the rotor-stator separation and the novel linear motor technique, accompanied by effective vibration isolation and optimized capacitance bridge electronics, achieves a resolution 6.5×10-12 N m Hz-1/2. This resolution, together with the low temperatures attainable, allows for experiments that probe the family of quantum fluid states responsible for the fractional quantum Hall effect, even at filling factors greater than one.

  13. Motif-based success scores in coauthorship networks are highly sensitive to author name disambiguation

    Science.gov (United States)

    Klosik, David F.; Bornholdt, Stefan; Hütt, Marc-Thorsten

    2014-09-01

    Following the work of Krumov et al. [Eur. Phys. J. B 84, 535 (2011), 10.1140/epjb/e2011-10746-5] we revisit the question whether the usage of large citation datasets allows for the quantitative assessment of social (by means of coauthorship of publications) influence on the progression of science. Applying a more comprehensive and well-curated dataset containing the publications in the journals of the American Physical Society during the whole 20th century we find that the measure chosen in the original study, a score based on small induced subgraphs, has to be used with caution, since the obtained results are highly sensitive to the exact implementation of the author disambiguation task.

  14. Piezoelectric Sensor to Measure Soft and Hard Stiffness with High Sensitivity for Ultrasonic Transducers

    Directory of Open Access Journals (Sweden)

    Yan-Rui Li

    2015-06-01

    Full Text Available During dental sinus lift surgery, it is important to monitor the thickness of the remaining maxilla to avoid perforating the sinus membrane. Therefore, a sensor should be integrated into ultrasonic dental tools to prevent undesirable damage. This paper presents a piezoelectric (PZT sensor installed in an ultrasonic transducer to measure the stiffness of high and low materials. Four design types using three PZT ring materials and a split PZT for actuator and sensor ring materials were studied. Three sensor locations were also examined. The voltage signals of the sensor and the displacement of the actuator were analyzed to distinguish the low and high stiffness. Using sensor type T1 made of the PZT-1 material and the front location A1 provided a high sensitivity of 2.47 Vm/kN. The experimental results demonstrated that our design can measure soft and hard stiffness.

  15. Baseline subtraction technique in the frequency-wavenumber domain for high sensitivity damage detection.

    Science.gov (United States)

    McKeon, Peter; Yaacoubi, Slah; Declercq, Nico F; Ramadan, Salah; Yaacoubi, Weina K

    2014-02-01

    This paper suggests a method for high-sensitivity damage detection. The method is based on pitch-catch measurements of Lamb waves combined with a baseline subtraction technique in the frequency-wavenumber domain. Small amplitude converted modes, generated during the interaction of propagating waves with damage, can thus be detected with minimal a priori information regarding their expected location in the frequency-wavenumber plane. This method is applied in the present paper to a case of notches with varied depth. Finite element simulations are carried out in the temporal domain to mimic results obtainable in real-world experiments. Two cases are studied, namely when each of the two pure fundamental modes are incident on a notch. The advantages of the method are detailed. The procedure to implement this method is described in the context of Structural Health Monitoring (SHM) or Non-Destructive Testing (NDT). Copyright © 2013 Elsevier B.V. All rights reserved.

  16. Highly Sensitive FPW-Based Microsystem for Rapid Detection of Tetrahydrocannabinol in Human Urine.

    Science.gov (United States)

    Lan, Je-Wei; Hsieh, Chia-Hsu; Huang, I-Yu; Lin, Yu-Cheng; Tsai, Tsung-Yi; Wang, Chua-Chin

    2017-11-29

    This paper presents a highly sensitive flexural plate-wave (FPW)-based microsystem for rapid detection of tetrahydrocannabinol (THC) in human urine. First, a circular-type interdigital transducer (IDT) was integrated with a circular-type silicon-grooved reflective grating structure (RGS) to reduce insertion loss. Then, with lower insertion loss (-38.758 dB), the FPW device was used to develop a novel THC biosensor, and the results reveal that this FPW-THC biosensor has low detection limit (1.5625 ng/mL) and high mass-sensitivity (126.67 cm²/g). Finally, this biosensor was integrated with field-programmable gate array (FPGA) board and discrete components for prototyping a FPW readout system, whose maximum error was 12.378 kHz to ensure that the linearity of detection up to R-square is equal to 0.9992.

  17. Highly Sensitive FPW-Based Microsystem for Rapid Detection of Tetrahydrocannabinol in Human Urine

    Directory of Open Access Journals (Sweden)

    Je-Wei Lan

    2017-11-01

    Full Text Available This paper presents a highly sensitive flexural plate-wave (FPW-based microsystem for rapid detection of tetrahydrocannabinol (THC in human urine. First, a circular-type interdigital transducer (IDT was integrated with a circular-type silicon-grooved reflective grating structure (RGS to reduce insertion loss. Then, with lower insertion loss (−38.758 dB, the FPW device was used to develop a novel THC biosensor, and the results reveal that this FPW-THC biosensor has low detection limit (1.5625 ng/mL and high mass-sensitivity (126.67 cm2/g. Finally, this biosensor was integrated with field-programmable gate array (FPGA board and discrete components for prototyping a FPW readout system, whose maximum error was 12.378 kHz to ensure that the linearity of detection up to R-square is equal to 0.9992.

  18. Elucidation of high sensitivity of δ-HMX: New insight from first principles simulations

    Science.gov (United States)

    Kuklja, Maija M.; Tsyshevsky, Roman V.; Sharia, Onise

    2017-01-01

    Understanding of a significant difference in sensitivities of β and δ phases of cyclotetramethylene-tetranitramine (HMX) has been long one of the challenges in the field of high energy density materials. Despite many experimental and theoretical efforts to explain the high sensitivity of the δ phase, convincing reasons behind the HMX behavior remained unclear. We established that the presence of a polar surface in δ-HMX has fundamental implications for stability and overall chemical behavior of the material. A comparative quantum-chemical analysis of decomposition mechanisms in polar δ-HMX and nonpolar β-HMX discovered a considerable difference in dominating dissociation reactions, activation barriers, and reaction rates. The polarization-induced charge transfer offered a logical explanation for different sensitivity of β-HMX and δ-HMX polymorphs to detonation initiation. Our conclusions also removed long-standing contradictions and explained a large range of experimental data on thermal decomposition of HMX.

  19. The diagnostic utility of High-Sensitivity Cardiac Troponin T in acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Manal Mohsen

    2016-03-01

    Conclusion: Our study demonstrated highly significant absolute and relative kinetic changes in hs-TnT levels in patients with AMI. The hs-TnT can be used for early rule in patients with MI as it could detect 97% of cases with MI whose Troponin I was negative and could detect 100% of cases of MI after 6–8 h compared to Troponin I which could detect only 21.2% of cases. This can be of great importance in the future introduction and use of the new high sensitive assay as a non-invasive reliable diagnostic tool to replace the currently used invasive diagnostic techniques for patients with ACS.

  20. High Sensitivity Bacillus thuringiensis Cry1Ac Protein Detections Using Fluorescein Diacetate Nanoparticles.

    Science.gov (United States)

    Liu, Cui; Zhou, Zhen; Zou, Linling; Cao, Yuan-Cheng; Liu, Jun'An; Lin, Yongjun

    2016-03-01

    A highly sensitive transgenic protein analysis method was proposed here based on fluorescein diacetate (FDA). First, FDA was prepared by the ball mill to harvest the nano-sized organic particles. Further examines showed that the FDA size can be controlled by the speed of centrifugation which can obtain FDA in well-distributed size. Cy3 antibody immobilization tests showed that the proteins can attach onto the FDA particles while keep bioactivities. FDA and Cry1Ac antibody immunoassay tests showed that when the FDA particle was in 150 nm, the linear range was 0.01 ng/L-30 μg/mL. And it has the lower detection limitation of 0.01 ng/L, which is 100 times more sensitive than the ELISA methods. These results indicate that the FDA related immunoassays are the promising approach in the transgenic analysis.

  1. High-sensitivity determination of radioactive cesium in Japanese foodstuffs. 3 years after the Fukushima accident

    International Nuclear Information System (INIS)

    Katsumi Shozugawa; Mayumi Hori; Motoyuki Matsuo

    2016-01-01

    We analyzed 134 Cs, 137 Cs and 40 K in 96 foodstuffs in supermarkets with high sensitivity over 3 years after Fukushima accident. Milk, yoghurt, rice, tea, salmon, cereal, blueberry, miso, and apples had a trace of 134 Cs and 137 Cs from 10 -3 to 100 Bq/kg, however, some mushrooms that were bought in the outer Fukushima prefecture were contaminated by radioactive cesium over the regulatory limit (100 Bq/kg). In view of the 134 Cs/ 137 Cs radioactivity ratio, we can conclude that 137 Cs detected in remote areas 300 km or more from Fukushima Nuclear power plant contained activity from Pre-Fukushima events such as Chernobyl accident (1986) and atmospheric nuclear explosions (from 1945). (author)

  2. A High Sensitivity Three-Dimensional-Shape Sensing Patch Prepared by Lithography and Inkjet Printing

    Directory of Open Access Journals (Sweden)

    Cheng-Yao Lo

    2012-03-01

    Full Text Available A process combining conventional photolithography and a novel inkjet printing method for the manufacture of high sensitivity three-dimensional-shape (3DS sensing patches was proposed and demonstrated. The supporting curvature ranges from 1.41 to 6.24 ´ 10−2 mm−1 and the sensing patch has a thickness of less than 130 μm and 20 ´ 20 mm2 dimensions. A complete finite element method (FEM model with simulation results was calculated and performed based on the buckling of columns and the deflection equation. The results show high compatibility of the drop-on-demand (DOD inkjet printing with photolithography and the interferometer design also supports bi-directional detection of deformation. The 3DS sensing patch can be operated remotely without any power consumption. It provides a novel and alternative option compared with other optical curvature sensors.

  3. Silver-coated Si nanograss as highly sensitive surface-enhanced Raman spectroscopy substrates

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Jing; Kuo, Huei Pei; Hu, Min; Li, Zhiyong; Williams, R.S. [Hewlett-Packard Laboratories, Information and Quantum Systems Laboratory, Palo Alto, CA (United States); Ou, Fung Suong [Hewlett-Packard Laboratories, Information and Quantum Systems Laboratory, Palo Alto, CA (United States); Rice University, Department of Applied Physics, Houston, TX (United States); Stickle, William F. [Hewlett-Packard Company, Advanced Diagnostic Lab, Corvallis, OR (United States)

    2009-09-15

    We created novel surface-enhanced Raman spectroscopy (SERS) substrates by metalization (Ag) of Si nanograss prepared by a Bosch process which involves deep reactive ion etching of single crystalline silicon. No template or lithography was needed for making the Si nanograss, thus providing a simple and inexpensive method to achieve highly sensitive large-area SERS substrates. The dependence of the SERS effect on the thickness of the metal deposition and on the surface morphology and topology of the substrate prior to metal deposition was studied in order to optimize the SERS signals. We observed that the Ag-coated Si nanograss can achieve uniform SERS enhancement over large area ({proportional_to}1 cm x 1 cm) with an average EF (enhancement factor) of 4.2 x 10{sup 8} for 4-mercaptophenol probe molecules. (orig.)

  4. 3D Printed Stretchable Capacitive Sensors for Highly Sensitive Tactile and Electrochemical Sensing.

    Science.gov (United States)

    Li, Kai; Wei, Hong; Liu, Wenguang; Meng, Hong; Zhang, Peixin; Yan, Chaoyi

    2018-02-15

    Developments of innovative strategies for the fabrication of stretchable sensors are of crucial importance for their applications in wearable electronic systems. In this work, we report the successful fabrication of stretchable capacitive sensors using a novel 3D printing method for highly sensitive tactile and electrochemical sensing applications. Unlike conventional lithographic or templated methods, the programmable 3D printing technique can fabricate complex device structures in a cost-effective and facile manner. We designed and fabricated stretchable capacitive sensors with interdigital and double-vortex designs and demonstrated their successful applications as tactile and electrochemical sensors. Especially, our stretchable sensors exhibited a detection limit as low as 1×10-6 M for NaCl aqueous solution, which could have significant potential applications when integrated in electronics skins. © 2018 IOP Publishing Ltd.

  5. A highly sensitive sensor for ethyl acetate by changing fluorescent colour of lanthanide complex.

    Science.gov (United States)

    Zhao, Lina

    2017-09-01

    A lanthanide complex, namely, [La 2 (L-DBTA) 3 (CH 3 OH) 2 (H 2 O) 2 ]∙2H2O has been synthesized using a simple reaction of L-O,O´-dibenzoyl tartaric acid with LaCl 3 ∙6H 2 O under ambient temperature. The luminescence spectrum in the solid state at room temperature revealed that the complex exhibited blue-light emission that originated from ligand. In addition, the lanthanide complex is developed as a fluorescent probe for sensing small molecules. Luminescence studies reveal that the lanthanide complex could detect ethyl acetate sensitively through fluorescence colour change from blue to yellow. Furthermore, the complex exhibited appealing features including high sensitivity and an ultrafast response. Copyright © 2017 John Wiley & Sons, Ltd.

  6. Application of advanced IR-FPA in high-sensitivity pushbroom SWIR hyperspectral imager

    Science.gov (United States)

    Wang, Yueming; Zhuang, Xiaoqiong; Wang, Shengwei; Wang, Jianyu

    2012-06-01

    High sensitivity SWIR(ShortWave Infra-Red) hyperspectral imager is benefit of national resources sensing. Background radiation results in noise and fluctuation of system's dark level, which does much harm to instrument's radiometric performance. Basing on the analysis of background radiation and object reflectance signal, a SWIR hyperspectral system solution is given which utilize advanced infrared focal plane array technology. By system integration and testing, it's showed that ROIC's charge to voltage gain plays an important role in enhancing Signal to Noise Ratio(SNR). At lower light condition, high gain of ROIC and long integration time will lead to smaller dynamic range because of background radiation. A real-time background radiation monitoring method was validated which did a favor for eliminating background radiation in the image data.

  7. Flexible, highly sensitive pressure sensor with a wide range based on graphene-silk network structure

    Science.gov (United States)

    Liu, Ying; Tao, Lu-Qi; Wang, Dan-Yang; Zhang, Tian-Yu; Yang, Yi; Ren, Tian-Ling

    2017-03-01

    In this paper, a flexible, simple-preparation, and low-cost graphene-silk pressure sensor based on soft silk substrate through thermal reduction was demonstrated. Taking silk as the support body, the device had formed a three-dimensional structure with ordered multi-layer structure. Through a simple and low-cost process technology, graphene-silk pressure sensor can achieve the sensitivity value of 0.4 kPa - 1 , and the measurement range can be as high as 140 kPa. Besides, pressure sensor can have a good combination with knitted clothing and textile product. The signal had good reproducibility in response to different pressures. Furthermore, graphene-silk pressure sensor can not only detect pressure higher than 100 kPa, but also can measure weak body signals. The characteristics of high-sensitivity, good repeatability, flexibility, and comfort for skin provide the high possibility to fit on various wearable electronics.

  8. High-sensitivity accelerometer composed of ultra-long vertically aligned barium titanate nanowire arrays.

    Science.gov (United States)

    Koka, Aneesh; Sodano, Henry A

    2013-01-01

    A configuration that shows great promise in sensing applications is vertically aligned piezoelectric nanowire arrays that allow facile interfacing with electrical interconnects. Nano-electromechanical systems developed using piezoelectric nanowires have gained interest primarily for their potential in energy harvesting applications, because they are able to convert several different sources of mechanical energy into useful electrical power. To date, no results have demonstrated the capability to use aligned piezoelectric nanowire arrays as a highly accurate nano-electromechanical system based dynamic sensor with a wide operating bandwidth and unity coherence. Here we report the growth of vertically aligned (~45 μm long) barium titanate nanowire arrays, realized through a two-step hydrothermal synthesis approach, and demonstrate their use as an accurate accelerometer. High sensitivity of up to 50 mV g(-1) is observed from the sensor composed of vertically aligned barium titanate nanowire arrays, thus providing performance comparable to many of the commercial accelerometer systems.

  9. Iridium Oxide Nanotube Electrodes for Highly Sensitive and Prolonged Intracellular Measurement of Action Potentials

    Science.gov (United States)

    Lin, Ziliang Carter; Xie, Chong; Osakada, Yasuko; Cui, Yi; Cui, Bianxiao

    2014-01-01

    Intracellular recording of action potentials is important to understand electrically-excitable cells. Recently, vertical nanoelectrodes have been developed to achieve highly sensitive, minimally invasive, and large scale intracellular recording. It has been demonstrated that the vertical geometry is crucial for the enhanced signal detection. Here we develop nanoelectrodes made up of nanotubes of iridium oxide. When cardiomyocytes are cultured upon those nanotubes, the cell membrane not only wraps around the vertical tubes but also protrudes deep into the hollow center. We show that this geometry enhances cell-electrode coupling and results in measuring much larger intracellular action potentials. The nanotube electrodes afford much longer intracellular access and are minimally invasive, making it possible to achieve stable recording up to an hour in a single session and more than 8 days of consecutive daily recording. This study suggests that the electrode performance can be significantly improved by optimizing the electrode geometry. PMID:24487777

  10. SML resist processing for high-aspect-ratio and high-sensitivity electron beam lithography

    Science.gov (United States)

    Mohammad, Mohammad Ali; Dew, Steven K.; Stepanova, Maria

    2013-03-01

    A detailed process characterization of SML electron beam resist for high-aspect-ratio nanopatterning at high sensitivity is presented. SML contrast curves were generated for methyl isobutyl ketone (MIBK), MIBK/isopropyl alcohol (IPA) (1:3), IPA/water (7:3), n-amyl acetate, xylene, and xylene/methanol (3:1) developers. Using IPA/water developer, the sensitivity of SML was improved considerably and found to be comparable to benchmark polymethylmethacrylate (PMMA) resist without affecting the aspect ratio performance. Employing 30-keV exposures and ultrasonic IPA/water development, an aspect ratio of 9:1 in 50-nm half-pitch dense grating patterns was achieved representing a greater than two times improvement over PMMA. Through demonstration of 25-nm lift-off features, the pattern transfer performance of SML is also addressed.

  11. Applications of molecules as high-resolution, high-sensitivity threshold electron detectors

    International Nuclear Information System (INIS)

    Chutjian, A.

    1991-01-01

    The goal of the work under the contract entitled ''Applications of Molecules as High-Resolution, High-Sensitivity Threshold Electron Detectors'' (DoE IAA No. DE-AI01-83ER13093 Mod. A006) was to explore the electron attachment properties of a variety of molecules at electron energies not accessible by other experimental techniques. As a result of this work, not only was a large body of basic data measured on attachment cross sections and rate constants; but also extensive theoretical calculations were carried out to verify the underlying phenomenon of s-wave attachment. Important outgrowths of this week were also realized in other areas of research. The basic data have applications in fields such as combustion, soot reduction, rocket-exhaust modification, threshold photoelectron spectroscopy, and trace species detection

  12. RAMA casein zymography: Time-saving and highly sensitive casein zymography for MMP7 and trypsin.

    Science.gov (United States)

    Yasumitsu, Hidetaro; Ozeki, Yasuhiro; Kanaly, Robert A

    2016-11-01

    To detect metalloproteinase-7 (MMP7), zymography is conducted using a casein substrate and conventional CBB stain. It has disadvantages because it is time consuming and has low sensitivity. Previously, a sensitive method to detect MMP7 up to 30 pg was reported, however it required special substrates and complicated handlings. RAMA casein zymography described herein is rapid, sensitive, and reproducible. By applying high-sensitivity staining with low substrate conditions, the staining process is completed within 1 h and sensitivity was increased 100-fold. The method can detect 10 pg MMP7 by using commercially available casein without complicated handlings. Moreover, it increases detection sensitivity for trypsin. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. A highly sensitive radioimmunoassay technique for subtyping the antibody to hepatitis B surface antigen

    International Nuclear Information System (INIS)

    Fang, C.T.; Nath, N.; Berberian, H.; Dodd, R.Y.

    1978-01-01

    A highly sensitive technique for determining the subtype specificity of antibody to hepatitis B surface antigen (anti-HBs) is described. Immunoadsorbent consisting of controlled pore glass coated with subtype specific HBsAg was used to remove homologous antibody from the test samples before testing them for residual antibody by a commercially available radioimmunoassay (RIA). A total of 73 anti-HBs-positive samples from asymptomatic blood donors were tested. In nearly 80% of these samples the subtype reactivity could be determined by this technique. Only 67% could be typed by conventional liquid phase absorption RIA and 22% by passive hemagglutination inhibition techniques. Among the samples with low anti-HBs titer, ad and ay subtypes were found with equal frequency; however, with the increase in anti-HBs titer, considerably higher proportion of ad specificity was detected. (Auth.)

  14. Highly Sensitive Local Surface Plasmon Resonance in Anisotropic Au Nanoparticles Deposited on Nanofibers

    Directory of Open Access Journals (Sweden)

    Masanari Saigusa

    2015-01-01

    Full Text Available This paper reports the facile and high-throughput fabrication method of anisotropic Au nanoparticles with a highly sensitive local surface plasmon resonance (LPR using cylindrical nanofibers as substrates. The substrates consisting of nanofibers were prepared by the electrospinning of poly(vinylidene fluoride (PVDF. The Au nanoparticles were deposited on the surface of electrospun nanofibers by vacuum evaporation. Scanning electron microscopy revealed the formation of a curved Au island structure on the surface of cylindrical nanofibers. Polarized UV-visible extinction spectroscopy showed anisotropy in their LPR arising from the high surface curvature of the nanofiber. The LPR of the Au nanoparticles on the thinnest nanofiber with a diameter of ~100 nm showed maximum refractive index (RI sensitivity over 500 nm/RI unit (RIU. The close correlation between the fiber diameter dependence of the RI sensitivity and polarization dependence of the LPR suggests that anisotropic Au nanoparticles improve RI sensitivity.

  15. High-sensitivity detection of triacetone triperoxide (TATP) and its precursor acetone

    Science.gov (United States)

    Dunayevskiy, Ilya; Tsekoun, Alexei; Prasanna, Manu; Go, Rowel; Patel, C. Kumar N.

    2007-09-01

    Triacetone triperoxide (C9H18O6, molecular mass of 222.24 g/mol) (TATP) is a powerful explosive that is easy to synthesize using commonly available household chemicals, acetone, and hydrogen peroxide 1 2. Because of the simplicity of its synthesis, TATP is often the explosive of choice for terrorists, including suicide bombers. For providing safety to the population, early detection of TATP and isolation of such individuals are essential. We report unambiguous, high-sensitivity detection of TATP and its precursor, acetone, using room-temperature quantum cascade laser photoacoustic spectroscopy (QCL-PAS). The available sensitivity is such that TATP, carried on a person (at a nominal body temperature of 37 °C), should be detectable at some distance. The combination of demonstrated detection of TATP and acetone should be ideal for screening at airports and other public places for providing increased public safety.

  16. An integrated low 1/f noise and high-sensitivity CMOS instrumentation amplifier for TMR sensors

    Science.gov (United States)

    Gao, Zhiqiang; Luan, Bo; Zhao, Jincai; Liu, Xiaowei

    2017-03-01

    In this paper, a very low 1/f noise integrated Wheatstone bridge magnetoresistive sensor ASIC based on magnetic tunnel junction (MTJ) technology is presented for high sensitivity measurements. The present CMOS instrumentation amplifier employs the gain-boost folded-cascode structure based on the capacitive-feedback chopper-stabilized technique. By chopping both the input and the output of the amplifier, combined with MTJ magnetoresistive sensitive elements, a noise equivalent magnetoresistance 1 nT/Hz1/2 at 2 Hz, the equivalent input noise spectral density 17 nV/Hz1/2(@2Hz) is achieved. The chip-scale package of the TMR sensor and the instrumentation amplifier is only about 5 mm × 5 mm × 1 mm, while the whole DC current dissipates only 2 mA.

  17. Highly sensitive iridium(iii) complex-based phosphorescent probe for thiophenol detection.

    Science.gov (United States)

    Xiong, Li; Yang, Lin; Luo, Shuai; Huang, Yan; Lu, Zhiyun

    2017-10-10

    A cyclometalated iridium(iii) complex (Ir-DNBS) was designed and synthesized as a high-performance phosphorescent thiophenol probe. Ir-DNBS displays a distinct phosphorescence "off-on" response toward thiophenol with high selectivity, high sensitivity (detection limit: 2.5 nM) and fast response (10 min). It is noteworthy that the signaling phosphore of Ir-DNBS possesses relatively high photoluminescence quantum efficiency (Φ PL = 0.21) together with relatively long lifetime (τ = 2.07 μs), indicative of its potential in achieving high temporal resolution. Ir-DNBS is also applicable to the detection of thiophenol in actual water samples with high recovery rate. Photophysical and spectral characterization results revealed that the probing mechanism of Ir-DNBS toward thiophenol lies in the thiolate-mediated cleavage reaction, resulting in suppressed photo-induced excited state electron transfer process in the reaction product.

  18. High Sensitivity Carbon Nanotubes Flow-Rate Sensors and Their Performance Improvement by Coating

    Science.gov (United States)

    Yang, Xing; Zhou, Zhaoying; Wang, Dingqu; Liu, Xiaoli

    2010-01-01

    A new type of hot-wire flow-rate sensor (HWFS) with a sensing element made of a macro-sized carbon nanotube (CNT) strand is presented in this study. An effective way to improve repeatability of the CNT flow-rate sensor by coating a layer of Al2O3 on the CNT surface is proposed. Experimental results show that due to the large surface-to-volume ratio and thin coated Al2O3 layer, the CNT flow-rate sensor has higher sensitivity and faster response than a conventional platinum (Pt) HWFS. It is also demonstrated that the covered CNT flow-rate sensor has better repeatability than its bare counterpart due to insulation from the surrounding environment. The proposed CNT flow-rate sensor shows application potential for high-sensitivity measurement of flow rate. PMID:22399913

  19. High sensitivity Hall devices with AlSb/InAs quantum well structures

    International Nuclear Information System (INIS)

    Zhang Yang; Zhang Yu-Wei; Wang Cheng-Yan; Guan Min; Cui Li-Jie; Li Yi-Yang; Wang Bao-Qiang; Zhu Zhan-Ping; Zeng Yi-Ping

    2013-01-01

    AlSb/InAs quantum well (QW) structures and InAs films on GaAs (001) substrates were grown by molecular beam epitaxy (MBE). We investigated the dependence of electron mobility and two-dimensional electron gas (2DEG) concentration on the thickness of an InAs channel. It is found that electron mobility as high as 19050 cm 2 · V −1 · s −1 has been achieved for an InAs channel of 22.5 nm. The Hall devices with high sensitivity and good temperature stability were fabricated based on the AlSb/InAs QW structures. Their sensitivity is markedly superior to Hall devices of InAs films. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  20. Design of a Matching Network for a High-Sensitivity Broadband Magnetic Resonance Sounding Coil Sensor.

    Science.gov (United States)

    Zhang, Yang; Teng, Fei; Li, Suhang; Wan, Ling; Lin, Tingting

    2017-10-27

    The magnetic resonance sounding (MRS) technique is a non-invasive geophysical method that can provide unique insights into the hydrological properties of groundwater. The Cu coil sensor is the preferred choice for detecting the weak MRS signal because of its high sensitivity, low fabrication complexity and low cost. The tuned configuration was traditionally used for the MRS coil sensor design because of its high sensitivity and narrowband filtering. However, its narrow bandwidth may distort the MRS signals. To address this issue, a non-tuned design exhibiting a broad bandwidth has emerged recently, however, the sensitivity decreases as the bandwidth increases. Moreover, the effect of the MRS applications is often seriously influenced by power harmonic noises in the developed areas, especially low-frequency harmonics, resulting in saturation of the coil sensor, regardless of the tuned or non-tuned configuration. To solve the two aforementioned problems, we propose a matching network consisting of an LC broadband filter in parallel with a matching capacitor and provide a design for a coil sensor with a matching network (CSMN). The theoretical parameter calculations and the equivalent schematic of the CSMN with noise sources are investigated, and the sensitivity of the CSMN is evaluated by the Allan variance and the signal-to-noise ratio (SNR). Correspondingly, we constructed the CSMN with a 3 dB bandwidth, passband gain, normalized equivalent input noise and sensitivity (detection limit) of 1030 Hz, 4.6 dB, 1.78 nV/(Hz) 1/2 @ 2 kHz and 3 nV, respectively. Experimental tests in the laboratory show that the CSMN can not only improve the sensitivity, but also inhibit the signal distortion by suppressing power harmonic noises in the strong electromagnetic interference environment. Finally, a field experiment is performed with the CSMN to show a valid measurement of the signals of an MRS instrument system.

  1. Development of high sensitivity and high speed large size blank inspection system LBIS

    Science.gov (United States)

    Ohara, Shinobu; Yoshida, Akinori; Hirai, Mitsuo; Kato, Takenori; Moriizumi, Koichi; Kusunose, Haruhiko

    2017-07-01

    The production of high-resolution flat panel displays (FPDs) for mobile phones today requires the use of high-quality large-size photomasks (LSPMs). Organic light emitting diode (OLED) displays use several transistors on each pixel for precise current control and, as such, the mask patterns for OLED displays are denser and finer than the patterns for the previous generation displays throughout the entire mask surface. It is therefore strongly demanded that mask patterns be produced with high fidelity and free of defect. To enable the production of a high quality LSPM in a short lead time, the manufacturers need a high-sensitivity high-speed mask blank inspection system that meets the requirement of advanced LSPMs. Lasertec has developed a large-size blank inspection system called LBIS, which achieves high sensitivity based on a laser-scattering technique. LBIS employs a high power laser as its inspection light source. LBIS's delivery optics, including a scanner and F-Theta scan lens, focus the light from the source linearly on the surface of the blank. Its specially-designed optics collect the light scattered by particles and defects generated during the manufacturing process, such as scratches, on the surface and guide it to photo multiplier tubes (PMTs) with high efficiency. Multiple PMTs are used on LBIS for the stable detection of scattered light, which may be distributed at various angles due to irregular shapes of defects. LBIS captures 0.3mμ PSL at a detection rate of over 99.5% with uniform sensitivity. Its inspection time is 20 minutes for a G8 blank and 35 minutes for G10. The differential interference contrast (DIC) microscope on the inspection head of LBIS captures high-contrast review images after inspection. The images are classified automatically.

  2. High Sensitivity TSS Prediction: Estimates of Locations Where TSS Cannot Occur

    KAUST Repository

    Schaefer, Ulf

    2013-10-10

    Background Although transcription in mammalian genomes can initiate from various genomic positions (e.g., 3′UTR, coding exons, etc.), most locations on genomes are not prone to transcription initiation. It is of practical and theoretical interest to be able to estimate such collections of non-TSS locations (NTLs). The identification of large portions of NTLs can contribute to better focusing the search for TSS locations and thus contribute to promoter and gene finding. It can help in the assessment of 5′ completeness of expressed sequences, contribute to more successful experimental designs, as well as more accurate gene annotation. Methodology Using comprehensive collections of Cap Analysis of Gene Expression (CAGE) and other transcript data from mouse and human genomes, we developed a methodology that allows us, by performing computational TSS prediction with very high sensitivity, to annotate, with a high accuracy in a strand specific manner, locations of mammalian genomes that are highly unlikely to harbor transcription start sites (TSSs). The properties of the immediate genomic neighborhood of 98,682 accurately determined mouse and 113,814 human TSSs are used to determine features that distinguish genomic transcription initiation locations from those that are not likely to initiate transcription. In our algorithm we utilize various constraining properties of features identified in the upstream and downstream regions around TSSs, as well as statistical analyses of these surrounding regions. Conclusions Our analysis of human chromosomes 4, 21 and 22 estimates ~46%, ~41% and ~27% of these chromosomes, respectively, as being NTLs. This suggests that on average more than 40% of the human genome can be expected to be highly unlikely to initiate transcription. Our method represents the first one that utilizes high-sensitivity TSS prediction to identify, with high accuracy, large portions of mammalian genomes as NTLs. The server with our algorithm implemented is

  3. Highly Sensitive Detection of Surface and Intercalated Impurities in Graphene by LEIS.

    Science.gov (United States)

    Průša, Stanislav; Procházka, Pavel; Bábor, Petr; Šikola, Tomáš; ter Veen, Rik; Fartmann, Michael; Grehl, Thomas; Brüner, Philipp; Roth, Dietmar; Bauer, Peter; Brongersma, Hidde H

    2015-09-08

    Low-energy ion scattering (LEIS) is known for its extreme surface sensitivity, as it yields a quantitative analysis of the outermost surface as well as highly resolved in-depth information for ultrathin surface layers. Hence, it could have been generally considered to be a suitable technique for the analysis of graphene samples. However, due to the low scattering cross section for light elements such as carbon, LEIS has not become a common technique for the characterization of graphene. In the present study we use a high-sensitivity LEIS instrument with parallel energy analysis for the characterization of CVD graphene transferred to thermal silica/silicon substrates. Thanks to its high sensitivity and the exceptional depth resolution typical of LEIS, the graphene layer closure was verified, and different kinds of contaminants were detected, quantified, and localized within the graphene structure. Utilizing the extraordinarily strong neutralization of helium by carbon atoms in graphene, LEIS experiments performed at several primary ion energies permit us to distinguish carbon in graphene from that in nongraphitic forms (e.g., the remains of a resist). Furthermore, metal impurities such as Fe, Sn, and Na located at the graphene-silica interface (intercalated) are detected, and the coverages of Fe and Sn are determined. Hence, high-resolution LEIS is capable of both checking the purity of graphene surfaces and detecting impurities incorporated into graphene layers or their interfaces. Thus, it is a suitable method for monitoring the quality of the whole fabrication process of graphene, including its transfer on various substrates.

  4. Molecular structure and thermodynamic predictions to create highly sensitive microRNA biosensors

    Energy Technology Data Exchange (ETDEWEB)

    Larkey, Nicholas E.; Brucks, Corinne N.; Lansing, Shan S.; Le, Sophia D.; Smith, Natasha M.; Tran, Victoria; Zhang, Lulu; Burrows, Sean M., E-mail: sean.burrows@oregonstate.edu

    2016-02-25

    Many studies have established microRNAs (miRNAs) as post-transcriptional regulators in a variety of intracellular molecular processes. Abnormal changes in miRNA have been associated with several diseases. However, these changes are sometimes subtle and occur at nanomolar levels or lower. Several biosensing hurdles for in situ cellular/tissue analysis of miRNA limit detection of small amounts of miRNA. Of these limitations the most challenging are selectivity and sensor degradation creating high background signals and false signals. Recently we developed a reporter+probe biosensor for let-7a that showed potential to mitigate false signal from sensor degradation. Here we designed reporter+probe biosensors for miR-26a-2-3p and miR-27a-5p to better understand the effect of thermodynamics and molecular structures of the biosensor constituents on the analytical performance. Signal changes from interactions between Cy3 and Cy5 on the reporters were used to understand structural aspects of the reporter designs. Theoretical thermodynamic values, single stranded conformations, hetero- and homodimerization structures, and equilibrium concentrations of the reporters and probes were used to interpret the experimental observations. Studies of the sensitivity and selectivity revealed 5–9 nM detection limits in the presence and absence of interfering off-analyte miRNAs. These studies will aid in determining how to rationally design reporter+probe biosensors to overcome hurdles associated with highly sensitive miRNA biosensing. - Highlights: • Challenges facing highly sensitive miRNA biosensor designs are addressed. • Thermodynamic and molecular structure design metrics for reporter+probe biosensors are proposed. • The influence of ideal and non-ideal reporter hairpin structures on reporter+probe formation and signal change are discussed. • 5–9 nM limits of detection were observed with no interference from off-analytes.

  5. A high sensitivity momentum flux measuring instrument for plasma thruster exhausts and diffusive plasmas.

    Science.gov (United States)

    West, Michael D; Charles, Christine; Boswell, Rod W

    2009-05-01

    A high sensitivity momentum flux measuring instrument based on a compound pendulum has been developed for use with electric propulsion devices and radio frequency driven plasmas. A laser displacement system, which builds upon techniques used by the materials science community for surface stress measurements, is used to measure with high sensitivity the displacement of a target plate placed in a plasma thruster exhaust. The instrument has been installed inside a vacuum chamber and calibrated via two different methods and is able to measure forces in the range of 0.02-0.5 mN with a resolution of 15 microN. Measurements have been made of the force produced from the cold gas flow and with a discharge ignited using argon propellant. The plasma is generated using a Helicon Double Layer Thruster prototype. The instrument target is placed about 1 mean free path for ion-neutral charge exchange collisions downstream of the thruster exit. At this position, the plasma consists of a low density ion beam (10%) and a much larger downstream component (90%). The results are in good agreement with those determined from the plasma parameters measured with diagnostic probes. Measurements at various flow rates show that variations in ion beam velocity and plasma density and the resulting momentum flux can be measured with this instrument. The instrument target is a simple, low cost device, and since the laser displacement system used is located outside the vacuum chamber, the measurement technique is free from radio frequency interference and thermal effects. It could be used to measure the thrust in the exhaust of other electric propulsion devices and the momentum flux of ion beams formed by expanding plasmas or fusion experiments.

  6. High sensitivity fiber optic angular displacement sensor and its application for detection of ultrasound.

    Science.gov (United States)

    Sakamoto, João Marcos Salvi; Kitano, Cláudio; Pacheco, Gefeson Mendes; Tittmann, Bernhard Rainer

    2012-07-10

    In this paper, we report on the development of an intensity-modulated fiber-optic sensor for angular displacement measurement. This sensor was designed to present high sensitivity, linear response, and wide bandwidth and, furthermore, to be simple and low cost. The sensor comprises two optical fibers, a positive lens, a reflective surface, an optical source, and a photodetector. A mathematical model was developed to determine and simulate the static characteristic curve of the sensor and to compare different sensor configurations regarding the core radii of the optical fibers. The simulation results showed that the sensor configurations tested are highly sensitive to small angle variation (in the range of microradians) with nonlinearity less than or equal to 1%. The normalized sensitivity ranges from (0.25×V(max)) to (2.40×V(max)) mV/μrad (where V(max) is the peak voltage of the static characteristic curve), and the linear range is from 194 to 1840 μrad. The unnormalized sensitivity for a reflective surface with reflectivity of 100% was measured as 7.7 mV/μrad. The simulations were compared with experimental results to validate the mathematical model and to define the most suitable configuration for ultrasonic detection. The sensor was tested on the characterization of a piezoelectric transducer and as part of a laser ultrasonics setup. The velocities of the longitudinal, shear, and surface waves were measured on aluminum samples as 6.43, 3.17, and 2.96 mm/μs, respectively, with an error smaller than 1.3%. The sensor, an alternative to piezoelectric or interferometric detectors, proved to be suitable for detection of ultrasonic waves and to perform time-of-flight measurements and nondestructive inspection.

  7. Design of a Matching Network for a High-Sensitivity Broadband Magnetic Resonance Sounding Coil Sensor

    Directory of Open Access Journals (Sweden)

    Yang Zhang

    2017-10-01

    Full Text Available The magnetic resonance sounding (MRS technique is a non-invasive geophysical method that can provide unique insights into the hydrological properties of groundwater. The Cu coil sensor is the preferred choice for detecting the weak MRS signal because of its high sensitivity, low fabrication complexity and low cost. The tuned configuration was traditionally used for the MRS coil sensor design because of its high sensitivity and narrowband filtering. However, its narrow bandwidth may distort the MRS signals. To address this issue, a non-tuned design exhibiting a broad bandwidth has emerged recently, however, the sensitivity decreases as the bandwidth increases. Moreover, the effect of the MRS applications is often seriously influenced by power harmonic noises in the developed areas, especially low-frequency harmonics, resulting in saturation of the coil sensor, regardless of the tuned or non-tuned configuration. To solve the two aforementioned problems, we propose a matching network consisting of an LC broadband filter in parallel with a matching capacitor and provide a design for a coil sensor with a matching network (CSMN. The theoretical parameter calculations and the equivalent schematic of the CSMN with noise sources are investigated, and the sensitivity of the CSMN is evaluated by the Allan variance and the signal-to-noise ratio (SNR. Correspondingly, we constructed the CSMN with a 3 dB bandwidth, passband gain, normalized equivalent input noise and sensitivity (detection limit of 1030 Hz, 4.6 dB, 1.78 nV/(Hz1/2 @ 2 kHz and 3 nV, respectively. Experimental tests in the laboratory show that the CSMN can not only improve the sensitivity, but also inhibit the signal distortion by suppressing power harmonic noises in the strong electromagnetic interference environment. Finally, a field experiment is performed with the CSMN to show a valid measurement of the signals of an MRS instrument system.

  8. Planning and decision making for aerial robots

    CERN Document Server

    Bestaoui Sebbane, Yasmina

    2014-01-01

    This book provides an introduction to the emerging field of planning and decision making for aerial robots. An aerial robot is the ultimate form of Unmanned Aerial Vehicle, an aircraft endowed with built-in intelligence, requiring no direct human control and able to perform a specific task. It must be able to fly within a partially structured environment, to react and adapt to changing environmental conditions and to accommodate for the uncertainty that exists in the physical world. An aerial robot can be termed as a physical agent that exists and flies in the real 3D world, can sense its environment and act on it to achieve specific goals. So throughout this book, an aerial robot will also be termed as an agent.   Fundamental problems in aerial robotics include the tasks of spatial motion, spatial sensing and spatial reasoning. Reasoning in complex environments represents a difficult problem. The issues specific to spatial reasoning are planning and decision making. Planning deals with the trajectory algori...

  9. An efficient protocol for the synthesis of highly sensitive indole imines utilizing green chemistry: optimization of reaction conditions.

    Science.gov (United States)

    Nisar, Bushra; Rubab, Syeda Laila; Raza, Abdul Rauf; Tariq, Sobia; Sultan, Ayesha; Tahir, Muhammad Nawaz

    2018-04-11

    Novel and highly sensitive indole-based imines have been synthesized. Their synthesis has been compared employing a variety of protocols. Ultimately, a convenient, economical and high yielding set of conditions employing green chemistry have been designed for their synthesis.

  10. High-sensitivity detection of cardiac troponin I with UV LED excitation for use in point-of-care immunoassay

    OpenAIRE

    Rodenko, Olga; Eriksson, Susann; Tidemand-Lichtenberg, Peter; Troldborg, Carl Peder; Fodgaard, Henrik; van Os, Sylvana; Pedersen, Christian

    2017-01-01

    High-sensitivity cardiac troponin assay development enables determination of biological variation in healthy populations, more accurate interpretation of clinical results and points towards earlier diagnosis and rule-out of acute myocardial infarction. In this paper, we report on preliminary tests of an immunoassay analyzer employing an optimized LED excitation to measure on a standard troponin I and a novel research high-sensitivity troponin I assay. The limit of detection is improved by fac...

  11. Integration of aerial imaging and variable-rate technology for site-specific aerial herbicide application

    Science.gov (United States)

    As remote sensing and variable rate technology are becoming more available for aerial applicators, practical methodologies on effective integration of these technologies are needed for site-specific aerial applications of crop production and protection materials. The objectives of this study were to...

  12. 22 CFR Appendix A to Part 62 - Certification of Responsible Officers and Sponsors

    Science.gov (United States)

    2010-04-01

    ... Sponsors A Appendix A to Part 62 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES...__. Subscribed and sworn to before me this ______ day of ______, 19__. Notary Public 2. Sponsors. I hereby...__. Notary Public ...

  13. "This program contains advertising": How the timing of sponsorship disclosure influences critical processing of sponsored content

    NARCIS (Netherlands)

    Boerman, S.; van Reijmersdal, E.; Neijens, P.

    2013-01-01

    This study investigates whether the timing of sponsorship disclosure influences the processing of sponsored content. A model is proposed in which sponsorship disclosure activates persuasion knowledge, which leads to critical processing of the sponsored content, and ultimately negatively affects the

  14. New Product Development. Engineering and Commerce Students Join Forces with a Corporate Sponsor.

    Science.gov (United States)

    Audet, Josee; Pegna, Joseph

    2001-01-01

    Mechanical engineering and business student teams developed new products using a corporate sponsor's technology in a simulated business setting. Students learned about product development and venture start-up, and the sponsor gained new applications for its patented technology. (SK)

  15. Manual for the application of NURE 1974--1977 aerial gamma-ray spectrometer data

    International Nuclear Information System (INIS)

    Saunders, D.F.; Potts, M.J.

    1977-09-01

    This manual was prepared as an aid to those interested in the interpretation and application of high-sensitivity aerial gamma-ray spectrometer data in uranium exploration. Particular emphasis is on the first 10 radiometric surveys performed under the National Uranium Resource Evaluation (NURE) program. The primary purpose of aerial gamma-ray spectrometer surveys in the NURE program is to map regional distributions of near-surface natural radioelements, i.e., the uranium and thorium decay series, and potassium-40. These data along with an understanding of the geochemical behavior of the pertinent isotopes under a variety of conditions allow uranium-enriched areas of the earth's crust (uraniferous provinces) to be identified as part of the regional appraisal phase of prospecting. Uranium ore deposits tend to occur more frequently in these generally enriched regions than elsewhere, and, consequently, uraniferous provinces constitute preferred territory for follow-up exploration methods such as detailed aerial or surface radiometric prospecting, geological studies, etc., to define potential prospects. These in turn may be investigated by still more detailed surface geological studies perhaps supplemented by radon or uranium geochemical surveys and exploration drilling and logging. This manual outlines the fundamentals of uranium geology and geochemistry along with interpretive approaches which may be used to identify statistically and geochemically significant uranium anomalies and uraniferous provinces. Follow-up prospecting methods are summarized along with guides to recent literature. Specific suggestions are made as to interpretive approaches and applicable follow-up prospecting procedures tailored to fit the data characteristics and general environment of each of the first 10 NURE aerial gamma-ray spectrometer surveys performed by Geodata International, Inc. and Texas Instruments Incorporated

  16. Highly sensitive multianalyte immunochromatographic test strip for rapid chemiluminescent detection of ractopamine and salbutamol

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Hongfei; Han, Jing; Yang, Shijia; Wang, Zhenxing; Wang, Lin; Fu, Zhifeng, E-mail: fuzf@swu.edu.cn

    2014-08-11

    Graphical abstract: A multianalyte immunochromatographic test strip was developed for the rapid detection of two β{sub 2}-agonists. Due to the application of chemiluminescent detection, this quantitative method shows much higher sensitivity. - Highlights: • An immunochromatographic test strip was developed for detection of multiple β{sub 2}-agonists. • The whole assay process can be completed within 20 min. • The proposed method shows much higher sensitivity due to the application of CL detection. • It is a portable analytical tool suitable for field analysis and rapid screening. - Abstract: A novel immunochromatographic assay (ICA) was proposed for rapid and multiple assay of β{sub 2}-agonists, by utilizing ractopamine (RAC) and salbutamol (SAL) as the models. Owing to the introduction of chemiluminescent (CL) approach, the proposed protocol shows much higher sensitivity. In this work, the described ICA was based on a competitive format, and horseradish peroxidase-tagged antibodies were used as highly sensitive CL probes. Quantitative analysis of β{sub 2}-agonists was achieved by recording the CL signals of the probes captured on the two test zones of the nitrocellulose membrane. Under the optimum conditions, RAC and SAL could be detected within the linear ranges of 0.50–40 and 0.10–50 ng mL{sup −1}, with the detection limits of 0.20 and 0.040 ng mL{sup −1} (S/N = 3), respectively. The whole process for multianalyte immunoassay of RAC and SAL can be completed within 20 min. Furthermore, the test strip was validated with spiked swine urine samples and the results showed that this method was reliable in measuring β{sub 2}-agonists in swine urine. This CL-based multianalyte test strip shows a series of advantages such as high sensitivity, ideal selectivity, simple manipulation, high assay efficiency and low cost. Thus, it opens up new pathway for rapid screening and field analysis, and shows a promising prospect in food safety.

  17. Scrambled eggs: A highly sensitive molecular diagnostic workflow for Fasciola species specific detection from faecal samples

    Science.gov (United States)

    Calvani, Nichola Eliza Davies; Windsor, Peter Andrew; Bush, Russell David

    2017-01-01

    Background Fasciolosis, due to Fasciola hepatica and Fasciola gigantica, is a re-emerging zoonotic parasitic disease of worldwide importance. Human and animal infections are commonly diagnosed by the traditional sedimentation and faecal egg-counting technique. However, this technique is time-consuming and prone to sensitivity errors when a large number of samples must be processed or if the operator lacks sufficient experience. Additionally, diagnosis can only be made once the 12-week pre-patent period has passed. Recently, a commercially available coprological antigen ELISA has enabled detection of F. hepatica prior to the completion of the pre-patent period, providing earlier diagnosis and increased throughput, although species differentiation is not possible in areas of parasite sympatry. Real-time PCR offers the combined benefits of highly sensitive species differentiation for medium to large sample sizes. However, no molecular diagnostic workflow currently exists for the identification of Fasciola spp. in faecal samples. Methodology/Principal findings A new molecular diagnostic workflow for the highly-sensitive detection and quantification of Fasciola spp. in faecal samples was developed. The technique involves sedimenting and pelleting the samples prior to DNA isolation in order to concentrate the eggs, followed by disruption by bead-beating in a benchtop homogeniser to ensure access to DNA. Although both the new molecular workflow and the traditional sedimentation technique were sensitive and specific, the new molecular workflow enabled faster sample throughput in medium to large epidemiological studies, and provided the additional benefit of speciation. Further, good correlation (R2 = 0.74–0.76) was observed between the real-time PCR values and the faecal egg count (FEC) using the new molecular workflow for all herds and sampling periods. Finally, no effect of storage in 70% ethanol was detected on sedimentation and DNA isolation outcomes; enabling

  18. Self-reported cocaine use is not associated with elevations in high-sensitivity troponin I.

    Science.gov (United States)

    Jordan, Candice D; Korley, Frederick K; Stolbach, Andrew I

    2017-06-01

    High-sensitivity troponin (hsTn) assays detect 10 times lower concentrations of cardiac troponin than conventional assays. We examined the effects of self-reported cocaine use to determine whether those with acute cocaine use being evaluated for ACS are more likely to have elevated hsTnI than those nonusers being evaluated for ACS. We conducted a sub-analysis of a prospective cohort of ED patients evaluated for acute coronary syndrome. Recent cocaine use was determined by structured patient interviews. High-sensitivity troponin (Abbott) and conventional troponin I (Abbott, cTnI) were measured on samples drawn at presentation. Urine toxicology screen for cocaine metabolite was obtained at the discretion of treating clinicians. Of 1862 patients enrolled, 444 reported prior cocaine use and 99 reported cocaine use within the preceding month. Median hsTn in patients with last cocaine use within 24 h, 2-7 days, 1 week-1 month, >1 month, and no prior cocaine use were: 9 (IQR: 3-17) ng/L, 6 (IQR: 3-24.3) ng/L, 6 (IQR: 3-89.5) ng/L, 3 (IQR: 3-18.5) ng/L and 3 (IQR: 3-17) ng/L, respectively. Urine toxicology assays (UTox) for cocaine were performed in 640 (34.4%) patients. The median hsTn for those who were UTox+, UTox - and those without a UTox were: 9 ng/L (IQR: 3-48.5), 9 ng/L (IQR: 3-40) and 3 ng/L (IQR: 3-12), respectively. There were no differences in the prevalence of new troponin elevations (hsTn >99th percentile but cTnI cocaine use compared to those without recent cocaine use. In this first investigation of hsTn in patients with self-reported recent cocaine use, we have determined that hsTn does not lead to an increase in the prevalence of troponin elevation in cocaine users.

  19. Scrambled eggs: A highly sensitive molecular diagnostic workflow for Fasciola species specific detection from faecal samples.

    Science.gov (United States)

    Calvani, Nichola Eliza Davies; Windsor, Peter Andrew; Bush, Russell David; Šlapeta, Jan

    2017-09-01

    Fasciolosis, due to Fasciola hepatica and Fasciola gigantica, is a re-emerging zoonotic parasitic disease of worldwide importance. Human and animal infections are commonly diagnosed by the traditional sedimentation and faecal egg-counting technique. However, this technique is time-consuming and prone to sensitivity errors when a large number of samples must be processed or if the operator lacks sufficient experience. Additionally, diagnosis can only be made once the 12-week pre-patent period has passed. Recently, a commercially available coprological antigen ELISA has enabled detection of F. hepatica prior to the completion of the pre-patent period, providing earlier diagnosis and increased throughput, although species differentiation is not possible in areas of parasite sympatry. Real-time PCR offers the combined benefits of highly sensitive species differentiation for medium to large sample sizes. However, no molecular diagnostic workflow currently exists for the identification of Fasciola spp. in faecal samples. A new molecular diagnostic workflow for the highly-sensitive detection and quantification of Fasciola spp. in faecal samples was developed. The technique involves sedimenting and pelleting the samples prior to DNA isolation in order to concentrate the eggs, followed by disruption by bead-beating in a benchtop homogeniser to ensure access to DNA. Although both the new molecular workflow and the traditional sedimentation technique were sensitive and specific, the new molecular workflow enabled faster sample throughput in medium to large epidemiological studies, and provided the additional benefit of speciation. Further, good correlation (R2 = 0.74-0.76) was observed between the real-time PCR values and the faecal egg count (FEC) using the new molecular workflow for all herds and sampling periods. Finally, no effect of storage in 70% ethanol was detected on sedimentation and DNA isolation outcomes; enabling transport of samples from endemic to non

  20. Scrambled eggs: A highly sensitive molecular diagnostic workflow for Fasciola species specific detection from faecal samples.

    Directory of Open Access Journals (Sweden)

    Nichola Eliza Davies Calvani

    2017-09-01

    Full Text Available Fasciolosis, due to Fasciola hepatica and Fasciola gigantica, is a re-emerging zoonotic parasitic disease of worldwide importance. Human and animal infections are commonly diagnosed by the traditional sedimentation and faecal egg-counting technique. However, this technique is time-consuming and prone to sensitivity errors when a large number of samples must be processed or if the operator lacks sufficient experience. Additionally, diagnosis can only be made once the 12-week pre-patent period has passed. Recently, a commercially available coprological antigen ELISA has enabled detection of F. hepatica prior to the completion of the pre-patent period, providing earlier diagnosis and increased throughput, although species differentiation is not possible in areas of parasite sympatry. Real-time PCR offers the combined benefits of highly sensitive species differentiation for medium to large sample sizes. However, no molecular diagnostic workflow currently exists for the identification of Fasciola spp. in faecal samples.A new molecular diagnostic workflow for the highly-sensitive detection and quantification of Fasciola spp. in faecal samples was developed. The technique involves sedimenting and pelleting the samples prior to DNA isolation in order to concentrate the eggs, followed by disruption by bead-beating in a benchtop homogeniser to ensure access to DNA. Although both the new molecular workflow and the traditional sedimentation technique were sensitive and specific, the new molecular workflow enabled faster sample throughput in medium to large epidemiological studies, and provided the additional benefit of speciation. Further, good correlation (R2 = 0.74-0.76 was observed between the real-time PCR values and the faecal egg count (FEC using the new molecular workflow for all herds and sampling periods. Finally, no effect of storage in 70% ethanol was detected on sedimentation and DNA isolation outcomes; enabling transport of samples from endemic

  1. Compact, highly sensitive optical gyros and sensors with fast-light

    Science.gov (United States)

    Christensen, Caleb A.; Zavriyev, Anton; Cummings, Malcolm; Beal, A. C.; Lucas, Mark; Lagasse, Michael

    2015-09-01

    Fast-light phenomena can enhance the sensitivity of an optical gyroscope of a given size by several orders of magnitude, and could be applied to other optical sensors as well. MagiQ Technologies has been developing a compact fiber-based fast light Inertial Measurement Unit (IMU) using Stimulated Brillouin Scattering in optical fibers with commercially mature technologies. We will report on our findings, including repeatable fast-light effects in the lab, numerical analysis of noise and stability given realistic optical specs, and methods for optimizing efficiency, size, and reliability with current technologies. The technology could benefit inertial navigation units, gyrocompasses, and stabilization techniques, and could allow high grade IMUs in spacecraft, unmanned aerial vehicles or sensors, where the current size and weight of precision gyros are prohibitive. By using photonic integrated circuits and telecom-grade components along with specialty fibers, we also believe that our design is appropriate for development without further advances in the state of the art of components.

  2. Stricter Employment Protection and Firms' Incentives to Sponsor Training

    DEFF Research Database (Denmark)

    Messe, Pierre-Jean; Rouland, Bénédicte

    2014-01-01

    This paper uses a difference-in-differences approach, combined with propensity score matching, to identify the effect of older workers employment protection on French firms' incentives to sponsor training. Between 1987 and 2008, French firms laying off workers aged over 50 had to pay a tax...... to the unemployment insurance system, known as the Delalande tax. In 1999, the measure was subjected to a reform that increased the tax, but only for large firms. We find that this exogenous increase substantially raised firms' incentives to train workers aged 45–49 but had no impact on the training rates among...

  3. American Medical Association sponsors press conference in home care.

    Science.gov (United States)

    Bayne, C G

    1996-01-01

    On September 12, 1996, the American Medical Association, with an educational grant from Hoffmann-La Roche, sponsored a National Press Conference in New York City at the Millenium Broadway Hotel on Times Square. Attended by more than 40 of the nation's top health care correspondents from the leading magazine and newspapers in the country, this conference was designed to promote "The Revolution in Home and Outpatient Care." With an emphasis on new sites and new technologies, speakers from the Academy of Homecare Physicians presented a number of related subjects.

  4. The Race for Sponsored Links: Bidding Patterns for Search Advertising

    OpenAIRE

    Zsolt Katona; Miklos Sarvary

    2010-01-01

    Paid placements on search engines reached sales of nearly $11 billion in the United States last year and represent the most rapidly growing form of online advertising today. In its classic form, a search engine sets up an auction for each search word in which competing websites bid for their sponsored links to be displayed next to the search results. We model this advertising market, focusing on two of its key characteristics: (1) the interaction between the list of search results and the lis...

  5. 45 CFR 2553.24 - What are a sponsor's responsibilities for securing community participation?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are a sponsor's responsibilities for securing community participation? 2553.24 Section 2553.24 Public Welfare Regulations Relating to Public Welfare... Eligibility and Responsibilities of a Sponsor § 2553.24 What are a sponsor's responsibilities for securing...

  6. 45 CFR 2551.24 - What are a sponsor's responsibilities for securing community participation?

    Science.gov (United States)

    2010-10-01

    ... Responsibilities of a Sponsor § 2551.24 What are a sponsor's responsibilities for securing community participation... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are a sponsor's responsibilities for securing community participation? 2551.24 Section 2551.24 Public Welfare Regulations Relating to Public Welfare...

  7. 45 CFR 2552.24 - What are a sponsor's responsibilities for securing community participation?

    Science.gov (United States)

    2010-10-01

    ... Responsibilities of a Sponsor § 2552.24 What are a sponsor's responsibilities for securing community participation... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are a sponsor's responsibilities for securing community participation? 2552.24 Section 2552.24 Public Welfare Regulations Relating to Public Welfare...

  8. Building Strong Bonds with Program Sponsors--Public Relations Ideas To Make It Happen.

    Science.gov (United States)

    Stephens, Karen

    2003-01-01

    Lists public relations strategies for child care center directors seeking to cultivate relationships with their program sponsors. Suggests ways to identify a public relations message, make the sponsor part of the child care family, become part of the sponsor's family, give public recognition, and share the children's accomplishments. (JPB)

  9. 42 CFR 423.553 - Effect of leasing of a PDP sponsor's facilities.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Effect of leasing of a PDP sponsor's facilities... Change of Ownership or Leasing of Facilities During Term of Contract § 423.553 Effect of leasing of a PDP sponsor's facilities. (a) General effect of leasing. If a PDP sponsor leases all or part of its facilities...

  10. 5 CFR 792.211 - What is the definition of a Federally sponsored child care center?

    Science.gov (United States)

    2010-01-01

    ... sponsored child care center? 792.211 Section 792.211 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... sponsored child care center? The term Federally sponsored child care center, for the purposes of this subpart, is a child care center that is located in a building or space that is owned or leased by the...

  11. High sensitivity point-of-care device for direct virus diagnostics

    DEFF Research Database (Denmark)

    Kiilerich-Pedersen, Katrine; Dapra, Johannes; Cherré, Solène

    2013-01-01

    Influenza infections are associated with high morbidity and mortality, carry the risk of pandemics, and pose a considerable economic burden worldwide. To improve the management of the illness, it is essential with accurate and fast point-of-care diagnostic tools for use in the field or at the pat......Influenza infections are associated with high morbidity and mortality, carry the risk of pandemics, and pose a considerable economic burden worldwide. To improve the management of the illness, it is essential with accurate and fast point-of-care diagnostic tools for use in the field...... or at the patient's bedside. Conventional diagnostic methods are time consuming, expensive and require specialized laboratory facilities. We present a highly sensitive, highly specific, and low cost platform to test for acute virus infections in less than 15. min, employing influenza A virus (H1N1) as an example...... of its usability. An all polymer microfluidic system with a functionalized conductive polymer (PEDOT-OH:TsO) microelectrode array was developed and exploited for label free and real time electrochemical detection of intact influenza A virus (H1N1) particles. DNA aptamers with affinity for influenza...

  12. Graphene prepared by one-pot solvent exfoliation as a highly sensitive platform for electrochemical sensing

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Can; Cheng, Qin [Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Wu, Kangbing, E-mail: kbwu@hust.edu.cn [Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Wu, Gang [Materials Physics and Applications Division, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Li, Qing, E-mail: qing_li_2@brown.edu [Materials Physics and Applications Division, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2014-05-01

    Highlights: • Graphene was prepared by one-step solvent exfoliation as superior electrode material. • Compared with RGO, prepared graphene exhibited stronger signal enhancement. • A widespread and highly-sensitive electrochemical sensing platform was constructed. - Abstract: Graphene was easily obtained via one-step ultrasonic exfoliation of graphite powder in N-methyl-2-pyrrolidone. Scanning electron microscopy, transmission electron microscopy, Raman and particle size measurements indicated that the exfoliation efficiency and the amount of produced graphene increased with ultrasonic time. The electrochemical properties and analytical applications of the resulting graphene were systematically studied. Compared with the predominantly-used reduced graphene oxides, the obtained graphene by one-step solvent exfoliation greatly enhanced the oxidation signals of various analytes, such as ascorbic acid (AA), dopamine (DA), uric acid (UA), xanthine (XA), hypoxanthine (HXA), bisphenol A (BPA), ponceau 4R, and sunset yellow. The detection limits of AA, DA, UA, XA, HXA, BPA, ponceau 4R, and sunset yellow were evaluated to be 0.8 μM, 7.5 nM, 2.5 nM, 4 nM, 10 nM, 20 nM, 2 nM, and 1 nM, which are much lower than the reported values. Thus, the prepared graphene via solvent exfoliation strategy displays strong signal amplification ability and holds great promise in constructing a universal and sensitive electrochemical sensing platform.

  13. Association of serum uric acid with high-sensitivity C-reactive protein in postmenopausal women.

    Science.gov (United States)

    Raeisi, A; Ostovar, A; Vahdat, K; Rezaei, P; Darabi, H; Moshtaghi, D; Nabipour, I

    2017-02-01

    To explore the independent correlation between serum uric acid and low-grade inflammation (measured by high-sensitivity C-reactive protein, hs-CRP) in postmenopausal women. A total of 378 healthy Iranian postmenopausal women were randomly selected in a population-based study. Circulating hs-CRP levels were measured by highly specific enzyme-linked immunosorbent assay method and an enzymatic calorimetric method was used to measure serum levels of uric acid. Pearson correlation coefficient, multiple linear regression and logistic regression models were used to analyze the association between uric acid and hs-CRP levels. A statistically significant correlation was seen between serum levels of uric acid and log-transformed circulating hs-CRP (r = 0.25, p uric acid levels (β = 0.20, p uric acid levels (odds ratio =1.52, 95% confidence interval 1.18-1.96). Higher serum uric acid levels were positively and independently associated with circulating hs-CRP in healthy postmenopausal women.

  14. An improved electrochemiluminescence polymerase chain reaction method for highly sensitive detection of plant viruses

    Energy Technology Data Exchange (ETDEWEB)

    Tang Yabing [MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631 (China); Xing Da [MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631 (China)]. E-mail: xingda@scnu.edu.cn; Zhu Debin [MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631 (China); Liu Jinfeng [MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631 (China)

    2007-01-23

    Recently, we have reported an electrochemiluminescence polymerase chain reaction (ECL-PCR) method for detection of genetically modified organisms. The ECL-PCR method was further improved in the current study by introducing a multi-purpose nucleic acid sequence that was specific to the tris(bipyridine) ruthenium (TBR) labeled probe, into the 5' terminal of the primers. The method was applied to detect plant viruses. Conserved sequence of the plant viruses was amplified by PCR. The product was hybridized with a biotin labeled probe and a TBR labeled probe. The hybridization product was separated by streptavidin-coated magnetic beads, and detected by measuring the ECL signals of the TBR labeled. Under the optimized conditions, the experiment results show that the detection limit is 50 fmol of PCR products, and the signal-to-noise ratio is in excess of 14.6. The method was used to detect banana streak virus, banana bunchy top virus, and papaya leaf curl virus. The experiment results show that this method could reliably identity viruses infected plant samples. The improved ECL-PCR approach has higher sensitivity and lower cost than previous approach. It can effectively detect the plant viruses with simplicity, stability, and high sensitivity.

  15. Development of gas analyzer to aim for speed and high sensitivity and shaping of mass spectrum

    International Nuclear Information System (INIS)

    Hatano, Toshihisa; Hiratsuka, Hajime; Abe, Tetsuya

    2011-01-01

    The gas analysis system with EI-QMS (Electron Ionization-Quadrupole Mass Spectrometer) developed by Japan Atomic Energy Agency (JAEA) is commercially available from a private company through a technology transfer. The system has already been used to a medical field such as breath analysis, a quality control of automobile casting parts made of recycled aluminum, and a measurement of food aromatic elements emitting from vegetable and sake. A pulse gas sampling and a continuous evacuation were integrated to the system that aimed at obtaining high sensitive and stable mass spectrum and accomplishing fast measurement prepared for 100% inspection of industrial parts and various foods. As a result, the system achieved a background pressure of 10 -7 Pa and a background ion current of 10 -13 A in the normal condition. An intensity of the mass spectrum decreased linearly with decreasing the pressure by the continuous evacuation, therefore, the intensity of the mass spectrum was corrected by the pump down curve, which is a new mathematical approach equivalent to a constant pressure curve. It was confirmed that the system had the sensing performance of 100 ppb. (author)

  16. A novel bioelectronic tongue in vivo for highly sensitive bitterness detection with brain-machine interface.

    Science.gov (United States)

    Qin, Zhen; Zhang, Bin; Hu, Liang; Zhuang, Liujing; Hu, Ning; Wang, Ping

    2016-04-15

    Animals' gustatory system has been widely acknowledged as one of the most sensitive chemosensing systems, especially for its ability to detect bitterness. Since bitterness usually symbolizes inedibility, the potential to use rodent's gustatory system is investigated to detect bitter compounds. In this work, the extracellular potentials of a group of neurons are recorded by chronically coupling microelectrode array to rat's gustatory cortex with brain-machine interface (BMI) technology. Local field potentials (LFPs), which represent the electrophysiological activity of neural networks, are chosen as target signals due to stable response patterns across trials and are further divided into different oscillations. As a result, different taste qualities yield quality-specific LFPs in time domain which suggests the selectivity of this in vivo bioelectronic tongue. Meanwhile, more quantitative study in frequency domain indicates that the post-stimulation power of beta and low gamma oscillations shows dependence with concentrations of denatonium benzoate, a prototypical bitter compound, and the limit of detection is deduced to be 0.076 μM, which is two orders lower than previous in vitro bioelectronic tongues and conventional electronic tongues. According to the results, this in vivo bioelectronic tongue in combination with BMI presents a promising method in highly sensitive bitterness detection and is supposed to provide new platform in measuring bitterness degree. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. A highly sensitive, label-free gene sensor based on a single conducting polymer nanowire.

    Science.gov (United States)

    Kannan, Bhuvaneswari; Williams, David E; Laslau, Cosmin; Travas-Sejdic, Jadranka

    2012-05-15

    A prerequisite for exploiting sensing devices based on semiconductor nanowires is ultra-sensitive and selective direct electrical detection of biological and chemical species. Here, we constructed a transducer based on copolymer of poly(3,4,-ethylenedioxythiophene) (PEDOT) and carboxylic group functionalised PEDOT single nanowire in between gold electrodes, followed by covalent attachment of amino-modified probe oligonucleotide. The target ODNs specific to Homo sapiens Breast and ovarian cancer cells were detected at femtomolar concentration and incorporation of negative controls (non-complementary ODN) were clearly discriminated by the sensor. The ex situ measurements were performed by using two terminal device setup and the changes in the interface of the nanowire associated with the association or dissociation of ODNs were measured as change in resistance. In addition, in situ measurements were performed by utilizing scanning ion conductance microscopy to measure the change in resistance of probe modified nanowire upon addition of different concentration of target ODNs in presence of relevant buffer. The constructed, nano sensor showed highly sensitive concentration dependent resistance change. Copyright © 2012 Elsevier B.V. All rights reserved.

  18. High-sensitivity imaging method of singlet oxygen and superoxide anion in photodynamic and sonodynamic actions

    Science.gov (United States)

    Xing, Da; He, Yonghong; Hao, Min; Chen, Qun

    2004-07-01

    A novel method of photodynamic diagnosis (PDD) of cancer mediated by chemiluminescence (CL) probe is presented. The mechanism for photodynamic therapy (PDT) involves reactive oxygen species (ROS), such as singlet oxygen (1O2) and superoxide (O2-), generated by during the photochemical process. Both 1O2 and O2- can react with Cypridina luciferin analogue (FCLA), a highly selective CL probe for detecting the ROS. Chemiluminescence from the reaction of FCLA with the ROS, at about 530 nm, was detected by a highly sensitive ICCD system. The CL was markedly inhibited by the addition of 10 mmol/L sodium azide (NaN3) in a sample solution. Similar phenomena, with lesser extents of changes, were observed at the additions of 10 μmol/L superoxide dismutase (SOD), 10 mmol/L mannitol, and 100 μg/mL catalase, respectively. This indicates that the detected CL signals were mainly from ROS generated during the photosensitization reactions. Also, the chemiluminescence method was used to detect the ROS during sonodynamic action, both in vitro and in vivo. ROS formation during sonosensitizations of HpD and ATX-70 were detected using our newly-developed imaging technique, in real time, on tumor bearing animals. This method can provide a new means in clinics for tumor diagnosis.

  19. A High Sensitivity IDC-Electronic Tongue Using Dielectric/Sensing Membranes with Solvatochromic Dyes.

    Science.gov (United States)

    Khan, Md Rajibur Rahaman; Khalilian, Alireza; Kang, Shin-Won

    2016-05-10

    In this paper, an electronic tongue/taste sensor array containing different interdigitated capacitor (IDC) sensing elements to detect different types of tastes, such as sweetness (glucose), saltiness (NaCl), sourness (HCl), bitterness (quinine-HCl), and umami (monosodium glutamate) is proposed. We present for the first time an IDC electronic tongue using sensing membranes containing solvatochromic dyes. The proposed highly sensitive (30.64 mV/decade sensitivity) IDC electronic tongue has fast response and recovery times of about 6 s and 5 s, respectively, with extremely stable responses, and is capable of linear sensing performance (R² ≈ 0.985 correlation coefficient) over the wide dynamic range of 1 µM to 1 M. The designed IDC electronic tongue offers excellent reproducibility, with a relative standard deviation (RSD) of about 0.029. The proposed device was found to have better sensing performance than potentiometric-, cascoded compatible lateral bipolar transistor (C-CLBT)-, Electronic Tongue (SA402)-, and fiber-optic-based taste sensing systems in what concerns dynamic range width, response time, sensitivity, and linearity. Finally, we applied principal component analysis (PCA) to distinguish between various kinds of taste in mixed taste compounds.

  20. Laser induced thermal lens microscopy for highly sensitive determination of captopril.

    Science.gov (United States)

    Shokoufi, Nader; Abbasi-Ahd, Atefeh; Kargosha, Kazem

    2017-04-10

    In this work, a combined flow injection-photo thermal lens microscopy (FI-PTLM) system was used for highly sensitive determination of captopril as an angiotensin-converting enzyme inhibitor. Captopril has no absorption in the visible range, but due to its thiol group could interact with gold nanoparticles (GNPs). GNPs, because of their surface plasmon resonance (SPR), have absorption in the visible range, but their interaction with a low concentration of captopril shows no effective change in UV-Vis spectrophotometry because their aggregation is slight. On the contrary, at the same condition, the PTLM with a visible light source enables sensitive measurement of this compound. The thiol group of captopril binds to the surface of GNPs and decreases the SPR. At the optimum condition in the focal volume of 2.68 fL (f=10-15), the obtained range of linearity was 50-800 nM. The developed method was successfully applied for the determination of captopril in human serum and pharmaceutical samples.

  1. A Germanium Detector with Optimized Compton Veto for High Sensitivity at Low Energy

    Energy Technology Data Exchange (ETDEWEB)

    Friedrich, S

    2011-11-30

    We have built a prototype germanium detector with a Compton veto that is optimized for high sensitivity in the low-energy range around {approx}100 keV. It is specifically designed to address the problem to directly detect plutonium gamma emissions in spent nuclear fuel by non-destructive assay. This is not possible with current detectors due to the large low-energy background of Compton-scattered high-energy radiation from the fission products, whose gamma flux is at least 6 to 7 orders of magnitude higher than the Pu signal. Our instrument is designed to assess the feasibility to selectively suppress the background in the low-energy region around {approx}100 keV with the strongest Pu X-ray and gamma emissions lines. It employs a thin Ge detector with a large Compton veto directly behind it to suppress the background from forward-scattered radiation by anti-coincidence vetoing. This report summarizes the design considerations and the performance of the instrument.

  2. Tumor cell-specific prodrugs using arsonic acid-presenting iron oxide nanoparticles with high sensitivity.

    Science.gov (United States)

    Minehara, Hiroki; Narita, Asako; Naka, Kensuke; Tanaka, Kazuo; Chujo, Moeko; Nagao, Masaya; Chujo, Yoshiki

    2012-08-01

    We report the tumor cell-selective prodrugs based on the arsonic acid-presenting iron oxide nanoparticles. We synthesized the well-dispersed nanoparticles having arsonoacetic acid which is composed of the low toxic As(V) form. From the analyses of the reaction products, it is suggested that the reduction by dithiothreitol with arsonoacetic acid and the modified nanoparticles could generate the highly-toxic As(III) species. In the MTT assays, it was found that the cell viabilities of HeLaS3 and especially HepG2 were reduced in the presence of the modified nanoparticles. In contrast, a slight effect on viability was observed with primary mouse hepatocytes. The viabilities showed good agreements with the amounts of intracellular reduced glutathione concentrations. Furthermore, the valid concentrations of the modified nanoparticles for tumor-specific cytotoxicity were similar level in MRI measurements. These results indicate that arsonic acid-presenting nanoparticles should be a good platform for developing highly-sensitive tumor-specific prodrugs. Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. Portable evanescent wave fiber biosensor for highly sensitive detection of Shigella

    Science.gov (United States)

    Xiao, Rui; Rong, Zhen; Long, Feng; Liu, Qiqi

    2014-11-01

    A portable evanescent wave fiber biosensor was developed to achieve the rapid and highly sensitive detection of Shigella. In this study, a DNA probe was covalently immobilized onto fiber-optic biosensors that can hybridize with a fluorescently labeled complementary DNA. The sensitivity of detection for synthesized oligonucleotides can reach 10-10 M. The surface of the sensor can be regenerated with 0.5% sodium dodecyl sulfate solution (pH 1.9) for over 30 times without significant deterioration of performance. The total analysis time for a single sample, including the time for measurement and surface regeneration, was less than 6 min. We employed real-time polymerase chain reaction (PCR) and compared the results of both methods to investigate the actual Shigella DNA detection capability of the fiber-optic biosensor. The fiber-optic biosensor could detect as low as 102 colony-forming unit/mL Shigella. This finding was comparable with that by real-time PCR, which suggests that this method is a potential alternative to existing detection methods.

  4. Highly sensitive detection of molecular interactions with plasmonic optical fiber grating sensors.

    Science.gov (United States)

    Voisin, Valérie; Pilate, Julie; Damman, Pascal; Mégret, Patrice; Caucheteur, Christophe

    2014-01-15

    Surface Plasmon resonance (SPR) optical fiber biosensors constitute a miniaturized counterpart to the bulky prism configuration and offer remote operation in very small volumes of analyte. They are a cost-effective and relatively straightforward technique to yield in situ (or even possibly in vivo) molecular detection. The biosensor configuration reported in this work uses nanometric-scale gold-coated tilted fiber Bragg gratings (TFBGs) interrogated by light polarized radially to the optical fiber outer surface, so as to maximize the optical coupling with the SPR. These gratings were recently associated to aptamers to assess their label-free biorecognition capability in buffer and serum solutions. In this work, using the well-acknowledged biotin-streptavidin pair as a benchmark, we go forward in the demonstration of their unique sensitivity. In addition to the monitoring of the self-assembled monolayer (SAM) in real time, we report an unprecedented limit of detection (LOD) as low as 2 pM. Finally, an immunosensing experiment is realized with human transferrin (dissociation constant Kd~10(-8) M(-1)). It allows to assess both the reversibility and the robustness of the SPR-TFBG biosensors and to confirm their high sensitivity. © 2013 Published by Elsevier B.V.

  5. Maltodextrin-based imaging probes detect bacteria in vivo with high sensitivity and specificity

    Science.gov (United States)

    Ning, Xinghai; Lee, Seungjun; Wang, Zhirui; Kim, Dongin; Stubblefield, Bryan; Gilbert, Eric; Murthy, Niren

    2011-08-01

    The diagnosis of bacterial infections remains a major challenge in medicine. Although numerous contrast agents have been developed to image bacteria, their clinical impact has been minimal because they are unable to detect small numbers of bacteria in vivo, and cannot distinguish infections from other pathologies such as cancer and inflammation. Here, we present a family of contrast agents, termed maltodextrin-based imaging probes (MDPs), which can detect bacteria in vivo with a sensitivity two orders of magnitude higher than previously reported, and can detect bacteria using a bacteria-specific mechanism that is independent of host response and secondary pathologies. MDPs are composed of a fluorescent dye conjugated to maltohexaose, and are rapidly internalized through the bacteria-specific maltodextrin transport pathway, endowing the MDPs with a unique combination of high sensitivity and specificity for bacteria. Here, we show that MDPs selectively accumulate within bacteria at millimolar concentrations, and are a thousand-fold more specific for bacteria than mammalian cells. Furthermore, we demonstrate that MDPs can image as few as 105 colony-forming units in vivo and can discriminate between active bacteria and inflammation induced by either lipopolysaccharides or metabolically inactive bacteria.

  6. Highly sensitive immunoassay of protein molecules based on single nanoparticle fluorescence detection in a nanowell

    Science.gov (United States)

    Han, Jin-Hee; Kim, Hee-Joo; Lakshmana, Sudheendra; Gee, Shirley J.; Hammock, Bruce D.; Kennedy, Ian M.

    2011-03-01

    A nanoarray based-single molecule detection system was developed for detecting proteins with extremely high sensitivity. The nanoarray was able to effectively trap nanoparticles conjugated with biological sample into nanowells by integrating with an electrophoretic particle entrapment system (EPES). The nanoarray/EPES is superior to other biosensor using immunoassays in terms of saving the amounts of biological solution and enhancing kinetics of antibody binding due to reduced steric hindrance from the neighboring biological molecules. The nanoarray patterned onto a layer of PMMA and LOL on conductive and transparent indium tin oxide (ITO)-glass slide by using e-beam lithography. The suspension of 500 nm-fluorescent (green emission)-carboxylated polystyrene (PS) particles coated with protein-A followed by BDE 47 polyclonal antibody was added to the chip that was connected to the positive voltage. The droplet was covered by another ITO-coated-glass slide and connected to a ground terminal. After trapping the particles into the nanowells, the solution of different concentrations of anti-rabbit- IgG labeled with Alexa 532 was added for an immunoassay. A single molecule detection system could quantify the anti-rabbit IgG down to atto-mole level by counting photons emitted from the fluorescent dye bound to a single nanoparticle in a nanowell.

  7. Use of high sensitivity GNSS receiver Doppler measurements for indoor pedestrian dead reckoning.

    Science.gov (United States)

    He, Zhe; Renaudin, Valérie; Petovello, Mark G; Lachapelle, Gérard

    2013-03-28

    Dead-reckoning (DR) algorithms, which use self-contained inertial sensors combined with gait analysis, have proven to be effective for pedestrian navigation purposes. In such DR systems, the primary error is often due to accumulated heading drifts. By tightly integrating global navigation satellite system (GNSS) Doppler measurements with DR, such accumulated heading errors can usually be accurately compensated. Under weak signal conditions, high sensitivity GNSS (HSGNSS) receivers with block processing techniques are often used, however, the Doppler quality of such receivers is relatively poor due to multipath, fading and signal attenuation. This often limits the benefits of integrating HSGNSS Doppler with DR. This paper investigates the benefits of using Doppler measurements from a novel direct vector HSGNSS receiver with pedestrian dead-reckoning (PDR) for indoor navigation. An indoor signal and multipath model is introduced which explains how conventional HSGNSS Doppler measurements are affected by indoor multipath. Velocity and Doppler estimated by using direct vector receivers are introduced and discussed. Real experimental data is processed and analyzed to assess the veracity of proposed method. It is shown when integrating HSGNSS Doppler with PDR algorithm, the proposed direct vector method are more helpful than conventional block processing method for the indoor environments considered herein.

  8. High sensitive method detection of plant RNA viruses by electrochemiluminescence reverse transcription PCR

    Science.gov (United States)

    Tang, Ya-bing; Xing, Da; Zhu, De-bin; Zhou, Xiao-ming

    2007-05-01

    It is well known that plant and animal viruses had widely spread the whole of world, and made a big loss in farming and husbandry. It is necessary that a highly efficient and accurate virus's detection method was developed. This research combines reverse transcription polymerase chain reaction (RT-PCR) technique with electrochemiluminescence method, to detect plant RNA viruses for the first time. Biotin-probe hybridizes with PCR product to specific select the target for detection, thus can avoid pseudo-positive result. TBR-probe hybridizes with PCR product to emit light for ECL detection. Specific nucleic acid sequences (20bp) were added to 5' terminal all of the primers, which can improve the chance of hybridization between TBR-probe and PCR product. At the same time, one of the PCR product chain can hybridize two Ru-probes, the ECL signal is intensified. The method was used to detect Odntoglossum ringspot virus ORSV, Sugarcane mosaic virus ScMV, Sorghum mosaic virus SrMV, and Maize dwarf mosaic virus MDMV, the experiment results show that this method could reliably identity virus infected plant samples. In a word, this method has higher sensitivity and lower cost than others. It can effectively detect the plant viruses with simplicity, stability, and high sensitivity.

  9. High sensitivity phase retrieval method in grating-based x-ray phase contrast imaging

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Zhao; Gao, Kun; Chen, Jian; Wang, Dajiang; Wang, Shenghao; Chen, Heng; Bao, Yuan; Shao, Qigang; Wang, Zhili, E-mail: wangnsrl@ustc.edu.cn [National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029 (China); Zhang, Kai [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Zhu, Peiping; Wu, Ziyu, E-mail: wuzy@ustc.edu.cn [National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China and Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

    2015-02-15

    Purpose: Grating-based x-ray phase contrast imaging is considered as one of the most promising techniques for future medical imaging. Many different methods have been developed to retrieve phase signal, among which the phase stepping (PS) method is widely used. However, further practical implementations are hindered, due to its complex scanning mode and high radiation dose. In contrast, the reverse projection (RP) method is a novel fast and low dose extraction approach. In this contribution, the authors present a quantitative analysis of the noise properties of the refraction signals retrieved by the two methods and compare their sensitivities. Methods: Using the error propagation formula, the authors analyze theoretically the signal-to-noise ratios (SNRs) of the refraction images retrieved by the two methods. Then, the sensitivities of the two extraction methods are compared under an identical exposure dose. Numerical experiments are performed to validate the theoretical results and provide some quantitative insight. Results: The SNRs of the two methods are both dependent on the system parameters, but in different ways. Comparison between their sensitivities reveals that for the refraction signal, the RP method possesses a higher sensitivity, especially in the case of high visibility and/or at the edge of the object. Conclusions: Compared with the PS method, the RP method has a superior sensitivity and provides refraction images with a higher SNR. Therefore, one can obtain highly sensitive refraction images in grating-based phase contrast imaging. This is very important for future preclinical and clinical implementations.

  10. High sensitivity phase retrieval method in grating-based x-ray phase contrast imaging

    International Nuclear Information System (INIS)

    Wu, Zhao; Gao, Kun; Chen, Jian; Wang, Dajiang; Wang, Shenghao; Chen, Heng; Bao, Yuan; Shao, Qigang; Wang, Zhili; Zhang, Kai; Zhu, Peiping; Wu, Ziyu

    2015-01-01

    Purpose: Grating-based x-ray phase contrast imaging is considered as one of the most promising techniques for future medical imaging. Many different methods have been developed to retrieve phase signal, among which the phase stepping (PS) method is widely used. However, further practical implementations are hindered, due to its complex scanning mode and high radiation dose. In contrast, the reverse projection (RP) method is a novel fast and low dose extraction approach. In this contribution, the authors present a quantitative analysis of the noise properties of the refraction signals retrieved by the two methods and compare their sensitivities. Methods: Using the error propagation formula, the authors analyze theoretically the signal-to-noise ratios (SNRs) of the refraction images retrieved by the two methods. Then, the sensitivities of the two extraction methods are compared under an identical exposure dose. Numerical experiments are performed to validate the theoretical results and provide some quantitative insight. Results: The SNRs of the two methods are both dependent on the system parameters, but in different ways. Comparison between their sensitivities reveals that for the refraction signal, the RP method possesses a higher sensitivity, especially in the case of high visibility and/or at the edge of the object. Conclusions: Compared with the PS method, the RP method has a superior sensitivity and provides refraction images with a higher SNR. Therefore, one can obtain highly sensitive refraction images in grating-based phase contrast imaging. This is very important for future preclinical and clinical implementations

  11. Highly Sensitive and Miniaturized Fluorescence Detection System with an Autonomous Capillary Fluid Manipulation Chip

    Directory of Open Access Journals (Sweden)

    Ji Fang

    2012-05-01

    Full Text Available This paper presents a novel, highly sensitive and ultra-small fluorescent detection system, including an autonomous capillary fluid manipulation chip. The optical detector integrates a LED light source, all necessary optical components, and a photodiode with preamplifier into one package of about 2 cm × 2 cm × 2 cm. Also, the low-cost and simple pumpless microfluidic device works well in sample preparation and manipulation. This chip consists of capillary stop valves and trigger valves which are fabricated by lithography and then bonded with a polydimethylsiloxane-ethylene oxide polymer polydimethylsiloxane (PEO-PDMS cover. The contact angle of the PEO-PDMS can be adjusted by changing the concentration of the PEO. Hence, the fluidic chip can achieve functionalities such as timing features and basic logical functions. The prototype has been tested by fluorescence dye 5-Carboxyfluorescein (5-FAM dissolved into the solvent DMSO (Dimethyl Sulfoxide. The results prove a remarkable sensitivity at a pico-scale molar, around 1.08 pM. The low-cost and miniaturized optical detection system, with a self-control capillary-driven microfluidic chip developed in this work, can be used as the crucial parts in portable biochemical detection applications and point of care testing.

  12. Fabrication of CuO nanoplatelets for highly sensitive enzyme-free determination of glucose

    Energy Technology Data Exchange (ETDEWEB)

    Wang Juan [School of Chemistry and Chemical Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510640 (China); Zhang Weide, E-mail: zhangwd@scut.edu.cn [School of Chemistry and Chemical Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510640 (China)

    2011-09-01

    Highlights: > Adhered growth of CuO nanoplatelets on Cu foils. > Enzyme-free glucose sensor with very high sensitivity. > Excellent stability and good anti-interference ability. - Abstract: CuO nanoplatelets were grown on Cu foils by a one step, template free process. The structure and morphology of the CuO nanoplatelets were characterized by X-ray diffraction, scanning and transmission electron microscopy. The CuO nanoplatelets grown on Cu foil were integrated to be an electrode for glucose sensing. The electrocatalytic activity of the CuO nanoplatelets electrode for glucose in alkaline media was investigated by cyclic voltammetry and chronoamperometry. The electrode exhibits a sensitivity of 3490.7 {mu}A mM{sup -1} cm{sup -2} to glucose which is much higher than that of most reported enzyme-free glucose sensors and the linear range was obtained over a concentration up to 0.80 mM with a detection limit of 0.50 {mu}M (signal/noise = 3). Exhilaratingly, the electrode based on the CuO nanoplatelets is resistant against poisoning by chloride ion, and the interference from the oxidation of common interfering species, such as uric acid, ascorbic acid, dopamine and carbonhydrate compounds, can also be effectively avoided. Finally, the electrode was applied to analyze glucose concentration in human serum samples.

  13. High sensitive photonic crystal multiplexed biosensor array using H0 sandwiched cavities

    Directory of Open Access Journals (Sweden)

    Arafa Safia

    2017-01-01

    Full Text Available We theoretically investigate a high sensitive photonic crystal integrated biosensor array structure which is potentially used for label-free multiplexed sensing. The proposed device consists of an array of three sandwiched H0 cavities patterned above silicon on insulator (SOI substrate; each cavity has been designed for different cavity spacing and different resonant wavelength. Results obtained by performing finite-difference time-domain (FDTD simulations, indicate that the response of each detection unit shifts independently in terms of refractive index variations. The optimized design makes possible the combination of sensing as a function of location, as well as a function of time in the same platform. A refractive index sensitivity of 520nm/RIU and a quality factor over 104 are both achieved with an accompanied crosstalk of less than -26 dB. In addition, the device presents an improved detection limit (DL of 1.24.10-6 RIU and a wide measurement range. These features make the designed device a promising element for performing label-free multiplexed detection in monolithic substrate for medical diagnostics and environmental monitoring.

  14. Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas

    Directory of Open Access Journals (Sweden)

    Lind Guro E

    2011-07-01

    Full Text Available Abstract Background The presence of cancer-specific DNA methylation patterns in epithelial colorectal cells in human feces provides the prospect of a simple, non-invasive screening test for colorectal cancer and its precursor, the adenoma. This study investigates a panel of epigenetic markers for the detection of colorectal cancer and adenomas. Methods Candidate biomarkers were subjected to quantitative methylation analysis in test sets of tissue samples from colorectal cancers, adenomas, and normal colonic mucosa. All findings were verified in independent clinical validation series. A total of 523 human samples were included in the study. Receiver operating characteristic (ROC curve analysis was used to evaluate the performance of the biomarker panel. Results Promoter hypermethylation of the genes CNRIP1, FBN1, INA, MAL, SNCA, and SPG20 was frequent in both colorectal cancers (65-94% and adenomas (35-91%, whereas normal mucosa samples were rarely (0-5% methylated. The combined sensitivity of at least two positives among the six markers was 94% for colorectal cancers and 93% for adenoma samples, with a specificity of 98%. The resulting areas under the ROC curve were 0.984 for cancers and 0.968 for adenomas versus normal mucosa. Conclusions The novel epigenetic marker panel shows very high sensitivity and specificity for both colorectal cancers and adenomas. Our findings suggest this biomarker panel to be highly suitable for early tumor detection.

  15. High-Sensitivity, Broad-Range Vacuum Gauge Using Nanotubes for Micromachined Cavities

    Science.gov (United States)

    Manohara, Harish; Kaul, Anupama B.

    2011-01-01

    A broad-range vacuum gauge has been created by suspending a single-walled carbon nanotube (SWNT) (metallic or semiconducting) in a Schottky diode format or in a bridge conductor format, between two electrically charged mesas. SWNTs are highly sensitive to molecular collisions because of their extremely small diameters in the range of 1 to 3 nanometers. The measurement parameter will be the change in conductivity of SWNT due to decreasing rate of molecular collisions as the pressure inside a chamber decreases. The rate of heat removal approaches a saturation limit as the mean free path (m.f.p.) lengths of molecules increase due to decreasing pressure. Only those sensing elements that have a long relaxation time can produce a measureable response when m.f.p. of molecules increases (or time between two consecutive collisions increases). A suspended SWNT offers such a capability because of its one-dimensional nature and ultrasmall diameter. In the initial approach, similar architecture was used as that of a SWNT-Schottky diode that has been developed at JPL, and has its changing conductivity measured as the test chamber is pumped down from atmospheric pressure to high vacuum (10(exp -7) Torr). Continuous response of decreasing conductivity has been measured as a function of decreasing pressure (SWNT is a negative thermal coefficient material) from atmosphere to less than 10(exp -6) Torr. A measureable current change in the hundreds of nA range has been recorded in the 10(exp -6) Torr regime.

  16. High-Sensitivity Troponin: A Clinical Blood Biomarker for Staging Cardiomyopathy in Fabry Disease.

    Science.gov (United States)

    Seydelmann, Nora; Liu, Dan; Krämer, Johannes; Drechsler, Christiane; Hu, Kai; Nordbeck, Peter; Schneider, Andreas; Störk, Stefan; Bijnens, Bart; Ertl, Georg; Wanner, Christoph; Weidemann, Frank

    2016-05-31

    High-sensitivity troponin (hs-TNT), a biomarker of myocardial damage, might be useful for assessing fibrosis in Fabry cardiomyopathy. We performed a prospective analysis of hs-TNT as a biomarker for myocardial changes in Fabry patients and a retrospective longitudinal follow-up study to assess longitudinal hs-TNT changes relative to fibrosis and cardiomyopathy progression. For the prospective analysis, hs-TNT from 75 consecutive patients with genetically confirmed Fabry disease was analyzed relative to typical Fabry-associated echocardiographic findings and total myocardial fibrosis as measured by late gadolinium enhancement (LE) on magnetic resonance imaging. Longitudinal data (3.9±2.0 years), including hs-TNT, LE, and echocardiographic findings from 58 Fabry patients, were retrospectively collected. Hs-TNT level positively correlated with LE (linear correlation coefficient, 0.72; odds ratio, 32.81 [95% CI, 3.56-302.59]; P=0.002); patients with elevated baseline hs-TNT (>14 ng/L) showed significantly increased LE (median: baseline, 1.9 [1.1-3.3] %; follow-up, 3.2 [2.3-4.9] %; PFabry disease and a qualified predictor of cardiomyopathy progression. Thus, hs-TNT could be helpful for staging and follow-up of Fabry patients. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  17. A Microneedle Functionalized with Polyethyleneimine and Nanotubes for Highly Sensitive, Label-Free Quantification of DNA.

    Science.gov (United States)

    Saadat-Moghaddam, Darius; Kim, Jong-Hoon

    2017-08-16

    The accurate measure of DNA concentration is necessary for many DNA-based biological applications. However, the current methods are limited in terms of sensitivity, reproducibility, human error, and contamination. Here, we present a microneedle functionalized with polyethyleneimine (PEI) and single-walled carbon nanotubes (SWCNTs) for the highly sensitive quantification of DNA. The microneedle was fabricated using ultraviolet (UV) lithography and anisotropic etching, and then functionalized with PEI and SWCNTs through a dip coating process. The electrical characteristics of the microneedle change with the accumulation of DNA on the surface. Current-voltage measurements in deionized water were conducted to study these changes in the electrical properties of the sensor. The sensitivity test found the signal to be discernable from the noise level down to 100 attomolar (aM), demonstrating higher sensitivity than currently available UV fluorescence and UV absorbance based methods. A microneedle without any surface modification only had a 100 femtomolar (fM) sensitivity. All measurement results were consistent with fluorescence microscopy.

  18. A car-borne highly sensitive near-IR diode-laser methane detector

    International Nuclear Information System (INIS)

    Berezin, A G; Ershov, Oleg V; Shapovalov, Yu P

    2003-01-01

    A highly sensitive automated car-borne detector for measuring methane concentration in real time is designed, developed and tested under laboratory and field conditions. Measurements were made with the help of an uncooled tunable near-IR 1.65-μm laser diode. The detector consists of a multipass optical cell with a 45-m long optical path and a base length of 0.5 m. The car-borne detector is intended for monitoring the methane concentration in air from the moving car to reveal the leakage of domestic gas. The sensitivity limit (standard deviation) under field conditions is 1 ppm (20 ppb under laboratory conditions) for a measuring time of 0.4 s. The measuring technique based on the detection of a single methane line ensured a high selectivity of methane detector relative to other gases. The methane detector can be easily modified for measuring other simple-molecule gases (e.g., CO, CO 2 , HF, NO 2 , H 2 O) by replacing the diode laser and varying the parameters of the control program. (special issue devoted to the memory of academician a m prokhorov)

  19. A Highly Sensitive Gold-Coated Photonic Crystal Fiber Biosensor Based on Surface Plasmon Resonance

    Directory of Open Access Journals (Sweden)

    Md. Rabiul Hasan

    2017-03-01

    Full Text Available In this paper, we numerically demonstrate a two-layer circular lattice photonic crystal fiber (PCF biosensor based on the principle of surface plasmon resonance (SPR. The finite element method (FEM with circular perfectly matched layer (PML boundary condition is applied to evaluate the performance of the proposed sensor. A thin gold layer is deposited outside the PCF structure, which acts as the plasmonic material for this design. The sensing layer (analyte is implemented in the outermost layer, which permits easy and more practical fabrication process compared to analyte is put inside the air holes. It is demonstrated that, at gold layer thickness of 40 nm, the proposed sensor shows maximum sensitivity of 2200 nm/RIU using the wavelength interrogation method in the sensing range between 1.33–1.36. Besides, using an amplitude interrogation method, a maximum sensitivity of 266 RIU−1 and a maximum sensor resolution of 3.75 × 10−5 RIU are obtained. We also discuss how phase matching points are varied with different fiber parameters. Owing to high sensitivity and simple design, the proposed sensor may find important applications in biochemical and biological analyte detection.

  20. Ultrahigh-speed, high-sensitivity color camera with 300,000-pixel single CCD

    Science.gov (United States)

    Kitamura, K.; Arai, T.; Yonai, J.; Hayashida, T.; Ohtake, H.; Kurita, T.; Tanioka, K.; Maruyama, H.; Namiki, J.; Yanagi, T.; Yoshida, T.; van Kuijk, H.; Bosiers, Jan T.; Etoh, T. G.

    2007-01-01

    We have developed an ultrahigh-speed, high-sensitivity portable color camera with a new 300,000-pixel single CCD. The 300,000-pixel CCD, which has four times the number of pixels of our initial model, was developed by seamlessly joining two 150,000-pixel CCDs. A green-red-green-blue (GRGB) Bayer filter is used to realize a color camera with the single-chip CCD. The camera is capable of ultrahigh-speed video recording at up to 1,000,000 frames/sec, and small enough to be handheld. We also developed a technology for dividing the CCD output signal to enable parallel, highspeed readout and recording in external memory; this makes possible long, continuous shots up to 1,000 frames/second. As a result of an experiment, video footage was imaged at an athletics meet. Because of high-speed shooting, even detailed movements of athletes' muscles were captured. This camera can capture clear slow-motion videos, so it enables previously impossible live footage to be imaged for various TV broadcasting programs.

  1. Highly Sensitive Detection of Minimal Cardiac Ischemia using Positron Emission Tomography Imaging of Activated Platelets

    Science.gov (United States)

    Ziegler, Melanie; Alt, Karen; Paterson, Brett M.; Kanellakis, Peter; Bobik, Alex; Donnelly, Paul S.; Hagemeyer, Christoph E.; Peter, Karlheinz

    2016-01-01

    A reliable method for the diagnosis of minimal cardiac ischemia would meet a strong demand for the sensitive diagnosis of coronary artery disease in cardiac stress testing and risk stratification in patients with chest pain but unremarkable ECGs and biomarkers. We hypothesized that platelets accumulate early on in ischemic myocardium and a newly developed technology of non-invasive molecular PET imaging of activated platelets can thus detect minimal degrees of myocardial ischemia. To induce different degrees of minimal cardiac ischemia, the left anterior descending artery (LAD) was ligated for 10, 20 or 60 min. Mice were injected with a newly generated scFvanti-GPIIb/IIIa-64CuMeCOSar radiotracer, composed of a single-chain antibody that only binds to activated integrin GPIIb/IIIa (αIIbβIII) and thus to activated platelets, and a sarcophagine cage MeCOSar complexing the long half-life PET tracer copper-64. A single PET/CT scan was performed. Evans Blue/TTC staining to detect necrosis as well as classical serological biomarkers like Troponin I and heart-type fatty acid-binding protein (H-FABP) were negative, whereas PET imaging of activated platelets was able to detect small degrees of ischemia. Taken together, molecular PET imaging of activated platelets represents a unique and highly sensitive method to detect minimal cardiac ischemia. PMID:27909290

  2. Highly sensitive analysis of sterol profiles in human serum by LC-ESI-MS/MS.

    Science.gov (United States)

    Honda, Akira; Yamashita, Kouwa; Miyazaki, Hiroshi; Shirai, Mutsumi; Ikegami, Tadashi; Xu, Guorong; Numazawa, Mitsuteru; Hara, Takashi; Matsuzaki, Yasushi

    2008-09-01

    We have developed a highly sensitive and specific method for the analysis of serum sterol profiles. Sterols in 1 mul of dried serum were derivatized into picolinyl esters (3beta-picolinate) and analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) using the electrospray ionization (ESI) mode. In addition to cholesterol, 19 cholesterol precursors, cholestanol, campesterol, sitosterol, and sitostanol were identified simultaneously. Quantitative analyses for the picolinyl esters of 11 available sterols were performed, and detection limits were found to be less than 1 pg on-column. Reproducibilities and recoveries of 8 noncholesterol sterols were validated according to one-way layout and polynomial equation, respectively. The variances between sample preparations and between measurements by this method were calculated to be 1.6% to 8.2% and 2.5% to 16.5%, respectively. The recovery experiments were performed using 1 mul aliquots of normal human serum spiked with 1 ng to 6 ng of sterols, and recoveries of the sterols ranged from 88.1% to 102.5% with a mean recovery of 98.1%. The present method provides reliable and reproducible results for the identification and quantification of neutral sterols, especially in small volumes of blood samples, which is useful for serological diagnosis of inherited disorders in cholesterol metabolism and for noninvasive evaluation of cholesterol biosynthesis and absorption in humans.

  3. Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS.

    Science.gov (United States)

    Honda, Akira; Yamashita, Kouwa; Hara, Takashi; Ikegami, Tadashi; Miyazaki, Teruo; Shirai, Mutsumi; Xu, Guorong; Numazawa, Mitsuteru; Matsuzaki, Yasushi

    2009-02-01

    We describe a highly sensitive and specific method for the quantification of key regulatory oxysterols in biological samples. This method is based upon a stable isotope dilution technique by liquid chromatography-tandem mass spectrometry (LC-MS/MS). After alkaline hydrolysis of human serum (5 microl) or rat liver microsomes (1 mg protein), oxysterols were extracted, derivatized into picolinyl esters, and analyzed by LC-MS/MS using the electrospray ionization mode. The detection limits of the picolinyl esters of 4beta-hydroxycholesterol, 7alpha-hydroxycholesterol, 22R-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol, and 24S,25-epoxycholesterol were 2-10 fg (5-25 amol) on-column (signal-to-noise ratio = 3). Reproducibilities and recoveries of these oxysterols were validated according to one-way layout and polynomial equation, respectively. The variances between sample preparations and between measurements by this method were calculated to be 1.8% to 12.7% and 2.9% to 11.9%, respectively. The recovery experiments were performed using rat liver microsomes spiked with 0.05 ng to 12 ng of oxysterols, and recoveries of the oxysterols ranged from 86.7% to 107.3%, with a mean recovery of 100.6%. This method provides reproducible and reliable results for the quantification of oxysterols in small amounts of biological samples.

  4. High-Sensitivity Ion Mobility Spectrometry/Mass Spectrometry Using Electrodynamic Ion Funnel Interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Keqi; Shvartsburg, Alexandre A.; Lee, Hak-No; Prior, David C.; Buschbach, Michael A.; Li, Fumin; Tolmachev, Aleksey V.; Anderson, Gordon A.; Smith, Richard D.

    2005-05-15

    The utility of ion mobility spectrometry (IMS) for separation of mixtures and structural characterization of ions has been demonstrated extensively, including in the biological and nanoscience contexts. A major attraction of IMS is its speed, several orders of magnitude above that of condensed-phase separations. Nonetheless, IMS combined with mass spectrometry (MS) has remained a niche technique, substantially due to limited sensitivity resulting from ion losses at the IMS-MS junction. We have developed a new electrospray ionization (ESI)-IMS-QToF MS instrument that incorporates electrodynamic ion funnels at both front ESI-IMS and back IMS-QToF interfaces. The front funnel is of the novel ''hourglass'' design that efficiently accumulates ions and pulses them into the IMS drift tubes. Even for drift tubes of two meter length, ion transmission through IMS and on to QToF is essentially lossless across the range of ion masses relevant to most applications. The RF ion focusing at IMS terminus does not degrade IMS resolving power, which exceeds 100 (for singly-charged ions) and is close to the theoretical limit. The overall sensitivity of present ESI-IMS-MS system is shown to be comparable to that of commercial ESI-MS, which should make IMS-MS suitable for analyses of complex mixtures with ultra-high sensitivity and exceptional throughput.

  5. High sensitivity pressure transducer based on the phase characteristics of GMI magnetic sensors

    Science.gov (United States)

    Benavides, L. S.; Costa Silva, E.; Costa Monteiro, E.; Hall Barbosa, C. R.

    2018-03-01

    This paper presents a new configuration for a GMI pressure transducer based on the reading of the phase characteristics of GMI sensor, intended for biomedical applications. The development process of this new class of magnetic field transducers is discussed, beginning with the definition of the ideal conditioning of the GMI sensor elements (dc level and frequency of the excitation current and sample length) and continuing with computational simulations of the full electronic circuit performed using the experimental data obtained from measured GMI curves, and have shown that the improvement in the sensitivity of GMI magnetometers is larger when phase-based transducers are used instead of magnitude-based transducers. Parameters of interest of the developed prototype are thoroughly analyzed, such as: sensitivity, linearity and frequency response. Also, the spectral noise density of the developed pressure transducer is evaluated and its resolution in the passband is estimated. A low-cost GMI pressure transducer was developed, presenting high resolution, high sensitivity and a frequency bandwidth compatible to the desired biomedical applications.

  6. Highly sensitive electrochemical determination of nitric oxide using fused spherical gold nanoparticles modified ITO electrode

    Energy Technology Data Exchange (ETDEWEB)

    Kannan, P. [Department of Chemistry, Gandhigram Rural University, Gandhigram 624 302, Dindigul, Tamil Nadu (India); John, S. Abraham, E-mail: abrajohn@yahoo.co.i [Department of Chemistry, Gandhigram Rural University, Gandhigram 624 302, Dindigul, Tamil Nadu (India)

    2010-04-01

    This paper describes the highly sensitive electrochemical determination of nitric oxide (NO) using the fused spherical gold nanoparticles (FAuNPs) modified ITO electrode. The FAuNPs were self-assembled on a (3-mercaptopropyl)-trimethoxysilane (MPTS) sol-gel film, which was preassembled on ITO electrode. The attachment of FAuNPs on MPTS sol-gel film was confirmed by UV-vis absorption spectroscopy, atomic force microscopy (AFM) and cyclic voltammetry (CV). The AFM image shows that the AuNPs retain their fused morphology after immobilized on MPTS sol-gel film. The FAuNPs modified ITO electrode shows an excellent electrocatalytic activity towards the oxidation of NO. Using FAuNPs modified electrode, the detection of 12 nM NO was achieved for the first time by amperometry method. Further, the current response was increased linearly with increasing NO concentration in the range of 1.2 x 10{sup -8} to 7 x 10{sup -4} M and the detection limit was found to be 3.1 x 10{sup -10} M (S/N = 3). The FAuNPs modified ITO electrode displays an excellent selectivity towards the determination of 12 nM NO even in the presence of 1000-fold excess common interfering agents.

  7. Study on the Highly Sensitive AChE Electrode Based on Multiwalled Carbon Nanotubes

    Directory of Open Access Journals (Sweden)

    Shuping Zhang

    2014-01-01

    Full Text Available Using chitosan (CS as carrier, the method named layer-by-layer (LBL self-assembly modification to modify the glassy carbon electrode (GCE with multiwalled carbon nanotubes (MWNTs and acetylcholine esterase (AChE was proposed to prepare the acetylcholine esterase electrode with high sensitivity and stability. The modified electrode was used to detect pesticide of aldicarb, and the enzyme inhibition rate of the electrode showed good linearity with pesticide concentrations in the range of 10−10 g·L−1 to 10−3 g·L−1. The detection limit was 10−11 g·L−1. The modified electrode was also used to detect the actual sample, and the recovery rate range was from 97.72% to 107.15%, which could meet the rapid testing need of the aldicarb residue. After being stored in the phosphate buffer solution (PBS in 4°C for 30 days, the modified electrode showed good stability with the response current that was 80% of the original current.

  8. Highly sensitive colorimetric determination of amoxicillin in pharmaceutical formulations based on induced aggregation of gold nanoparticles

    Science.gov (United States)

    Akhond, Morteza; Absalan, Ghodratollah; Ershadifar, Hamid

    2015-05-01

    A novel, simple and highly sensitive colorimetric method is developed for determination of Amoxicillin (AMX). The system is based on aggregation of citrate-capped gold nanoparticles (AuNP) in acetate buffer (pH = 4.5) in the presence of the degradation product of Amoxicillin (DPAMX). It was found that the color of gold nanoparticles changed from red to purple and the intensity of surface plasmon resonance (SPR) peak of AuNPs decreased. A new absorption band was appeared in the wavelength range of 600-700 nm upon addition of DPAMX. The absorbance ratio at the wavelength of 660 and 525 nm (A660/A525) was chosen as the analytical signal indirectly related to AMX concentration. The linearity of the calibration graph was found over the concentration range of 0.3-4.5 μM AMX with a correlation coefficient of 0.9967. Under the optimum experimental conditions, the detection limit was found to be 0.15 μM. The applicability of the method was successfully demonstrated by analysis of AMX in pharmaceutical formulations including capsules and oral suspensions.

  9. Scattering measurement of single particle for highly sensitive homogeneous detection of DNA in serum.

    Science.gov (United States)

    Zhu, Liang; Li, Guohua; He, Yonghong; Tan, Hui; Sun, Shuqing

    2018-02-01

    A highly sensitive homogeneous method for DNA detection has been developed. The system relies on two kinds of gold nanorod (AuNR) probes with complementary DNA sequences to the target DNA. In the presence of the target DNA, two kinds of AuNR probes are assembling into dimers or small aggregates. The target-induced AuNR aggregate has higher scattering intensity than that of a single AuNR because of the plasmonic coupling effect. Dark field microscopy was utilized to image the single particle and measure its scattering intensity. We wrote our own Matlab code and used it to extract the scattering signal of all particles. Difference in distribution of scattering intensity between the single AuNR and its aggregate provides a quantitative basis for the detection of target DNA. A linear dynamic range spanning from 0.1pM to 1nM and a detection limit of ~ 30fM were achieved for the detection of DNA in serum sample. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Highly Sensitive DNA Sensor Based on Upconversion Nanoparticles and Graphene Oxide.

    Science.gov (United States)

    Alonso-Cristobal, P; Vilela, P; El-Sagheer, A; Lopez-Cabarcos, E; Brown, T; Muskens, O L; Rubio-Retama, J; Kanaras, A G

    2015-06-17

    In this work we demonstrate a DNA biosensor based on fluorescence resonance energy transfer (FRET) between NaYF4:Yb,Er nanoparticles and graphene oxide (GO). Monodisperse NaYF4:Yb,Er nanoparticles with a mean diameter of 29.1 ± 2.2 nm were synthesized and coated with a SiO2 shell of 11 nm, which allowed the attachment of single strands of DNA. When these DNA-functionalized NaYF4:Yb,Er@SiO2 nanoparticles were in the proximity of the GO surface, the π-π stacking interaction between the nucleobases of the DNA and the sp(2) carbons of the GO induced a FRET fluorescence quenching due to the overlap of the fluorescence emission of the NaYF4:Yb,Er@SiO2 and the absorption spectrum of GO. By contrast, in the presence of the complementary DNA strands, the hybridization leads to double-stranded DNA that does not interact with the GO surface, and thus the NaYF4:Yb,Er@SiO2 nanoparticles remain unquenched and fluorescent. The high sensitivity and specificity of this sensor introduces a new method for the detection of DNA with a detection limit of 5 pM.

  11. Graphene ``microdrums'' on a freestanding perforated thin membrane for high sensitivity MEMS pressure sensors

    Science.gov (United States)

    Wang, Qiugu; Hong, Wei; Dong, Liang

    2016-03-01

    We present a microelectromechanical system (MEMS) graphene-based pressure sensor realized by transferring a large area, few-layered graphene on a suspended silicon nitride thin membrane perforated by a periodic array of micro-through-holes. Each through-hole is covered by a circular drum-like graphene layer, namely a graphene ``microdrum''. The uniqueness of the sensor design is the fact that introducing the through-hole arrays into the supporting nitride membrane allows generating an increased strain in the graphene membrane over the through-hole array by local deformations of the holes under an applied differential pressure. Further reasons contributing to the increased strain in the devised sensitive membrane include larger deflection of the membrane than that of its imperforated counterpart membrane, and direct bulging of the graphene microdrum under an applied pressure. Electromechanical measurements show a gauge factor of 4.4 for the graphene membrane and a sensitivity of 2.8 × 10-5 mbar-1 for the pressure sensor with a good linearity over a wide pressure range. The present sensor outperforms most existing MEMS-based small footprint pressure sensors using graphene, silicon, and carbon nanotubes as sensitive materials, due to the high sensitivity.

  12. Highly Sensitive Strain Sensors Based on Fragmentized Carbon Nanotube/Polydimethylsiloxane Composites.

    Science.gov (United States)

    Gao, Yang; Fang, Xiaoliang; Tan, Janping; Lu, Ting; Pan, Linkun; Xuan, Fu-Zhen

    2018-03-21

    Wearable strain sensors based on nanomaterial/elastomer composites have potential applications in flexible electronic skin, human motion detection, human-machine interfaces, etc. In this research, a type of high performance strain sensors have been developed using fragmentized carbon nanotube/polydimethylsiloxane (CNT/PDMS) composites. The CNT/PDMS composites were ground into fragments, and a liquid-induced densification method was used to fabricate the strain sensors. The strain sensors showed high sensitivity with gauge factors (GFs) larger than 200 and a broad strain detection range up to 80%, much higher than those strain sensors based on unfragmentized CNT/PDMS composites (GF <1). The enhanced sensitivity of the strain sensors is ascribed to the sliding of individual fragmentized-CNT/PDMS-composite particles during mechanical deformation, which causes significant resistance change in the strain sensors. The strain sensors can differentiate mechanical stimuli and monitor various human body motions, such as bending of the fingers, human breathing, and blood pulsing. © 2018 IOP Publishing Ltd.

  13. Novel Highly Sensitive Protein Sensors Based on Tapered Optical Fibres Modified with Au-Based Nanocoatings

    Directory of Open Access Journals (Sweden)

    Aitor Urrutia

    2016-01-01

    Full Text Available Novel protein sensors based on tapered optical fibres modified with Au coatings deposited using two different procedures are proposed. Au-based coatings are deposited onto a nonadiabatic tapered optical fibre using (i a novel facile method composed of layer-by-layer deposition consisting of polycation (poly(allylamine hydrochloride, PAH and negatively charged SiO2 nanoparticles (NPs followed by the deposition of the charged Au NPs and (ii the sputtering technique. The Au NPs and Au thin film surfaces are then modified with biotin in order to bind streptavidin (SV molecules and detect them. The sensing principle is based on the sensitivity of the transmission spectrum of the device to changes in the refractive index of the coatings induced by the SV binding to the biotin. Both sensors showed high sensitivity to SV, with the lowest measured concentration levels below 2.5 nM. The calculated binding constant for the biotin-SV pair was 2.2×10-11 M−1 when a tapered fibre modified with the LbL method was used, with a limit of detection (LoD of 271 pM. The sensor formed using sputtering had a binding constant of 1.01×10-10 M−1 with a LoD of 806 pM. These new structures and their simple fabrication technique could be used to develop other biosensors.

  14. High sensitivity pH sensing on the BEOL of industrial FDSOI transistors

    Science.gov (United States)

    Rahhal, Lama; Ayele, Getenet Tesega; Monfray, Stéphane; Cloarec, Jean-Pierre; Fornacciari, Benjamin; Pardoux, Eric; Chevalier, Celine; Ecoffey, Serge; Drouin, Dominique; Morin, Pierre; Garnier, Philippe; Boeuf, Frederic; Souifi, Abdelkader

    2017-08-01

    In this work we demonstrate the use of Fully Depleted Silicon On Insulator (FDSOI) transistors as pH sensors with a 23 nm silicon nitride sensing layer built in the Back-End-Of-Line (BEOL). The back end process to deposit the sensing layer and fabricate the electrical structures needed for testing is detailed. A series of tests employing different pH buffer solutions has been performed on transistors of different geometries, controlled via the back gate. The main findings show a shift of the drain current (ID) as a function of the back gate voltage (VB) when different pH buffer solutions are probed in the range of pH 6 to pH 8. This shift is observed at VB voltages swept from 0 V to 3 V, demonstrating the sensor operation at low voltage. A high sensitivity of up to 250 mV/pH unit (more than 4-fold larger than Nernstian response) is observed on FDSOI MOS transistors of 0.06 μm gate length and 0.08 μm gate width. She is currently working as a Postdoctoral researcher at Institut des nanotechnologies de Lyon in collaboration with STMicroelectronics and Université de Sherbrook (Canada) working on ;Integration of ultra-low-power gas and pH sensors with advanced technologies;. Her research interest includes selection, machining, optimisation and electrical characterisation of the sensitive layer for a low power consumption gas sensor based on advanced MOS transistors.

  15. Highly Sensitive Bacteriophage-Based Detection of Brucella abortus in Mixed Culture and Spiked Blood

    Science.gov (United States)

    Sergueev, Kirill V.; Filippov, Andrey A.; Nikolich, Mikeljon P.

    2017-01-01

    For decades, bacteriophages (phages) have been used for Brucella species identification in the diagnosis and epidemiology of brucellosis. Traditional Brucella phage typing is a multi-day procedure including the isolation of a pure culture, a step that can take up to three weeks. In this study, we focused on the use of brucellaphages for sensitive detection of the pathogen in clinical and other complex samples, and developed an indirect method of Brucella detection using real-time quantitative PCR monitoring of brucellaphage DNA amplification via replication on live Brucella cells. This assay allowed the detection of single bacteria (down to 1 colony-forming unit per milliliter) within 72 h without DNA extraction and purification steps. The technique was equally efficient with Brucella abortus pure culture and with mixed cultures of B. abortus and α-proteobacterial near neighbors that can be misidentified as Brucella spp., Ochrobactrum anthropi and Afipia felis. The addition of a simple short sample preparation step enabled the indirect phage-based detection of B. abortus in spiked blood, with the same high sensitivity. This indirect phage-based detection assay enables the rapid and sensitive detection of live B. abortus in mixed cultures and in blood samples, and can potentially be applied for detection in other clinical samples and other complex sample types. PMID:28604602

  16. High-Q Fabry–Pérot Micro-Cavities for High-Sensitivity Volume Refractometry

    Directory of Open Access Journals (Sweden)

    Noha Gaber

    2018-01-01

    Full Text Available This work reports a novel structure for a Fabry–Pérot micro cavity that combines the highest reported quality factor for an on-chip Fabry–Pérot resonator that exceeds 9800, and a very high sensitivity for an on-chip volume refractometer based on a Fabry–Pérot cavity that is about 1000 nm/refractive index unit (RIU. The structure consists of two cylindrical Bragg micromirrors that achieve confinement of the Gaussian beam in the plan parallel to the chip substrate, while for the perpendicular plan, external fiber rod lenses (FRLs are placed in the optical path of the input and the output of the cavity. This novel structure overcomes number of the drawbacks presented in previous designs. The analyte is passed between the mirrors, enabling its detection from the resonance peak wavelengths of the transmission spectra. Mixtures of ethanol and deionized (DI-water with different ratios are used as analytes with different refractive indices to exploit the device as a micro-opto-fluidic refractometer. The design criteria are detailed and the modeling is based on Gaussian-optics equations, which depicts a scenario closer to reality than the usually used ray-optics modeling.

  17. Highly Sensitive Liquid Core Temperature Sensor Based on Multimode Interference Effects

    Directory of Open Access Journals (Sweden)

    Miguel A. Fuentes-Fuentes

    2015-10-01

    Full Text Available A novel fiber optic temperature sensor based on a liquid-core multimode interference device is demonstrated. The advantage of such structure is that the thermo-optic coefficient (TOC of the liquid is at least one order of magnitude larger than that of silica and this, combined with the fact that the TOC of silica and the liquid have opposite signs, provides a liquid-core multimode fiber (MMF highly sensitive to temperature. Since the refractive index of the liquid can be easily modified, this allows us to control the modal properties of the liquid-core MMF at will and the sensor sensitivity can be easily tuned by selecting the refractive index of the liquid in the core of the device. The maximum sensitivity measured in our experiments is 20 nm/°C in the low-temperature regime up to 60 °C. To the best of our knowledge, to date, this is the largest sensitivity reported for fiber-based MMI temperature sensors.

  18. Geometry dependence of temperature coefficient of resonant frequency in highly sensitive resonant thermal sensors

    Science.gov (United States)

    Inomata, Naoki; Ono, Takahito

    2017-08-01

    In this paper, the geometry dependence of the temperature coefficient of resonant frequency (TCRF) is investigated and compared with a theoretical thermal stress change using Si mechanical microresonators. The used resonators have Y, T, I (conventional double-supported type) and arrow shapes, and in each shape the resonant frequency change of the resonator is measured in relation to changes in the amount of heat input to the resonator. The change trend in the experimental resonant frequency and the theoretical thermal stress in changing the temperature are consist. The TCRF in each resonator is Y: -653, T: -162, I: -417, and the arrow is 174 ppm/K. These absolute values are much higher than those of conventional cantilevered Si resonators (-34.9 ppm/K). In addition, the frequency fluctuations based on Allan deviation are experimentally evaluated considering the theoretical thermal fluctuation noise. It is considered that use of this technique to improve the TCRF of resonators by changing the geometry has the possibility of creating a sensor with highly sensitive thermal detection.

  19. Demonstration of a highly sensitive photoacoustic spectrometer based on a miniaturized all-optical detecting sensor.

    Science.gov (United States)

    Zhou, Sheng; Slaman, Martin; Iannuzzi, Davide

    2017-07-24

    We report on the development of a highly sensitive photoacoustic (PA) spectrometer based on a miniaturized all-optical detecting sensor. The sensor has a cell volume of less than 6 μL and relies on a cantilever-based acoustic transducer, which is equipped with an optical fiber interferometric readout. The spectrometer reaches a noise equivalent concentration of 15 ppb (300 ms time constant) for acetylene detection using a 23 mW excitation laser source, which corresponds to a normalized noise equivalent absorption coefficient of 7.7 × 10 -10 W cm -1 Hz -1/2 . The performance offered by this PA spectrometer is thus comparable to those reported for bulkier PA analyzers. Furthermore, because both the excitation and detection signals are brought to the PA cell via optical fibers, our spectrometer can be used in harsh environments, where electronic devices are prone to failure, and it is specially suitable for multiplexed remote detection applications. We believe that our study paves the way for the development of PA spectrometers that allow in-situ gas detection in space-limited circumstances.

  20. Theoretical Study of Monolayer and Double-Layer Waveguide Love Wave Sensors for Achieving High Sensitivity.

    Science.gov (United States)

    Li, Shuangming; Wan, Ying; Fan, Chunhai; Su, Yan

    2017-03-22

    Love wave sensors have been widely used for sensing applications. In this work, we introduce the theoretical analysis of the monolayer and double-layer waveguide Love wave sensors. The velocity, particle displacement and energy distribution of Love waves were analyzed. Using the variations of the energy repartition, the sensitivity coefficients of Love wave sensors were calculated. To achieve a higher sensitivity coefficient, a thin gold layer was added as the second waveguide on top of the silicon dioxide (SiO₂) waveguide-based, 36 degree-rotated, Y-cut, X-propagating lithium tantalate (36° YX LiTaO₃) Love wave sensor. The Love wave velocity was significantly reduced by the added gold layer, and the flow of wave energy into the waveguide layer from the substrate was enhanced. By using the double-layer structure, almost a 72-fold enhancement in the sensitivity coefficient was achieved compared to the monolayer structure. Additionally, the thickness of the SiO₂ layer was also reduced with the application of the gold layer, resulting in easier device fabrication. This study allows for the possibility of designing and realizing robust Love wave sensors with high sensitivity and a low limit of detection.

  1. Highly Sensitive Bacteriophage-Based Detection of Brucella abortus in Mixed Culture and Spiked Blood

    Directory of Open Access Journals (Sweden)

    Kirill V. Sergueev

    2017-06-01

    Full Text Available For decades, bacteriophages (phages have been used for Brucella species identification in the diagnosis and epidemiology of brucellosis. Traditional Brucella phage typing is a multi-day procedure including the isolation of a pure culture, a step that can take up to three weeks. In this study, we focused on the use of brucellaphages for sensitive detection of the pathogen in clinical and other complex samples, and developed an indirect method of Brucella detection using real-time quantitative PCR monitoring of brucellaphage DNA amplification via replication on live Brucella cells. This assay allowed the detection of single bacteria (down to 1 colony-forming unit per milliliter within 72 h without DNA extraction and purification steps. The technique was equally efficient with Brucella abortus pure culture and with mixed cultures of B. abortus and α-proteobacterial near neighbors that can be misidentified as Brucella spp., Ochrobactrum anthropi and Afipia felis. The addition of a simple short sample preparation step enabled the indirect phage-based detection of B. abortus in spiked blood, with the same high sensitivity. This indirect phage-based detection assay enables the rapid and sensitive detection of live B. abortus in mixed cultures and in blood samples, and can potentially be applied for detection in other clinical samples and other complex sample types.

  2. Highly Sensitive Bacteriophage-Based Detection of Brucella abortus in Mixed Culture and Spiked Blood.

    Science.gov (United States)

    Sergueev, Kirill V; Filippov, Andrey A; Nikolich, Mikeljon P

    2017-06-10

    For decades, bacteriophages (phages) have been used for Brucella species identification in the diagnosis and epidemiology of brucellosis. Traditional Brucella phage typing is a multi-day procedure including the isolation of a pure culture, a step that can take up to three weeks. In this study, we focused on the use of brucellaphages for sensitive detection of the pathogen in clinical and other complex samples, and developed an indirect method of Brucella detection using real-time quantitative PCR monitoring of brucellaphage DNA amplification via replication on live Brucella cells. This assay allowed the detection of single bacteria (down to 1 colony-forming unit per milliliter) within 72 h without DNA extraction and purification steps. The technique was equally efficient with Brucella abortus pure culture and with mixed cultures of B . abortus and α-proteobacterial near neighbors that can be misidentified as Brucella spp., Ochrobactrum anthropi and Afipia felis . The addition of a simple short sample preparation step enabled the indirect phage-based detection of B . abortus in spiked blood, with the same high sensitivity. This indirect phage-based detection assay enables the rapid and sensitive detection of live B . abortus in mixed cultures and in blood samples, and can potentially be applied for detection in other clinical samples and other complex sample types.

  3. Theoretical Study of Monolayer and Double-Layer Waveguide Love Wave Sensors for Achieving High Sensitivity

    Directory of Open Access Journals (Sweden)

    Shuangming Li

    2017-03-01

    Full Text Available Love wave sensors have been widely used for sensing applications. In this work, we introduce the theoretical analysis of the monolayer and double-layer waveguide Love wave sensors. The velocity, particle displacement and energy distribution of Love waves were analyzed. Using the variations of the energy repartition, the sensitivity coefficients of Love wave sensors were calculated. To achieve a higher sensitivity coefficient, a thin gold layer was added as the second waveguide on top of the silicon dioxide (SiO2 waveguide–based, 36 degree–rotated, Y-cut, X-propagating lithium tantalate (36° YX LiTaO3 Love wave sensor. The Love wave velocity was significantly reduced by the added gold layer, and the flow of wave energy into the waveguide layer from the substrate was enhanced. By using the double-layer structure, almost a 72-fold enhancement in the sensitivity coefficient was achieved compared to the monolayer structure. Additionally, the thickness of the SiO2 layer was also reduced with the application of the gold layer, resulting in easier device fabrication. This study allows for the possibility of designing and realizing robust Love wave sensors with high sensitivity and a low limit of detection.

  4. Rough surface Au@Ag core-shell nanoparticles to fabricating high sensitivity SERS immunochromatographic sensors.

    Science.gov (United States)

    Fu, Qiangqiang; Liu, Hongwu Liu; Wu, Ze; Liu, An; Yao, Cuize; Li, Xiuqing; Xiao, Wei; Yu, Shiting; Luo, Zhi; Tang, Yong

    2015-11-14

    Immunochromatographic sensors (ICSs) are inexpensive, simple, portable, and robust, thus making ICSs commonplace in clinical diagnoses, food testing, and environmental monitoring. However, commonly used gold nanoparticles (AuNPs) ICSs have low sensitivity. Therefore, we developed highly sensitive surface enhanced Raman scattering (SERS) ICSs. To enhance the sensitivity of SERS ICSs, rough surface core-shell Au@Ag nanoparticles (RSAu@AgNPs) were prepared by coating silver on the surface of gold nanoflowers (AuNFs). Then these nanoparticles were used as SERS substrate in the SERS ICSs, after which the SERS ICSs were implemented to detect haemoglobin and heavy metal cadmium ion (Cd(2+)). The limit of detection (LOD) of the SERS ICSs for detecting haemoglobin was 8 ng/mL, and the linear range of the SERS ICSs was from 31.3 to 2000 ng/mL. The LOD of the SERS ICSs for detecting Cd(2+) was 0.05 ng/mL and the linear analysis range was from 0.05 to 25 ng/mL. The cross reactivity of the SERS ICSs was studied and results showed that the SERS ICSs exhibited highly specific for detection of haemoglobin and Cd(2+), respectively. The SERS ICSs were then used to detect haemoglobin (spiked in serum and in stool) and Cd(2+) (spiked in tap water, river water, and soil leaching water), and the results showed high recovery. These characteristics indicated that SERS ICSs were ideal tools for clinical diagnosis and environmental pollution monitoring.

  5. Establishment of a new marginal plaque index with high sensitivity for changes in oral hygiene.

    Science.gov (United States)

    Deinzer, Renate; Jahns, Stephan; Harnacke, Daniela

    2014-12-01

    Although several plaque indices exist, they rarely assess in detail the plaque adjacent to the gingival margin, an area most important for periodontal health. This study aims to develop a new marginal plaque index (MPI) and to assess its validity and treatment sensitivity compared to the internationally accepted Turesky modification of the Quigley and Hein Index (TQHI). Data from two studies with n = 64 and n = 67 participants, respectively, are reported here. Convergence of MPI with TQHI and concurrent and predictive validity with papillary bleeding index were assessed, as was treatment sensitivity to a treatment of proximal hygiene (study 1) or toothbrushing (study 2), respectively. Convergent validity with TQHI is very good. Concurrent and predictive validity parameters of the MPI are similar to the TQHI. The treatment sensitivity of MPI exceeds TQHI by far. This results in a reduction by >70% of the sample size needed to discover significant treatment effects. As expected, the largest treatment sensitivity was observed for proximal MPI measures in study 1, whereas study 2 showed largest effects for cervical measures. MPI appears to be a valid plaque-scoring system that assesses plaque at the gingival margin. It responds with high sensitivity to treatments aimed at plaque reduction at the gingival margin. Its treatment sensitivity and capacity to differentiate between proximal and cervical plaque make it a promising tool for periodontal research.

  6. Highly sensitive dual mode electrochemical platform for microRNA detection

    Science.gov (United States)

    Jolly, Pawan; Batistuti, Marina R.; Miodek, Anna; Zhurauski, Pavel; Mulato, Marcelo; Lindsay, Mark A.; Estrela, Pedro

    2016-11-01

    MicroRNAs (miRNAs) play crucial regulatory roles in various human diseases including cancer, making them promising biomarkers. However, given the low levels of miRNAs present in blood, their use as cancer biomarkers requires the development of simple and effective analytical methods. Herein, we report the development of a highly sensitive dual mode electrochemical platform for the detection of microRNAs. The platform was developed using peptide nucleic acids as probes on gold electrode surfaces to capture target miRNAs. A simple amplification strategy using gold nanoparticles has been employed exploiting the inherent charges of the nucleic acids. Electrochemical impedance spectroscopy was used to monitor the changes in capacitance upon any binding event, without the need for any redox markers. By using thiolated ferrocene, a complementary detection mode on the same sensor was developed where the increasing peaks of ferrocene were recorded using square wave voltammetry with increasing miRNA concentration. This dual-mode approach allows detection of miRNA with a limit of detection of 0.37 fM and a wide dynamic range from 1 fM to 100 nM along with clear distinction from mismatched target miRNA sequences. The electrochemical platform developed can be easily expanded to other miRNA/DNA detection along with the development of microarray platforms.

  7. Screening for cocaine on Euro banknotes by a highly sensitive enzyme immunoassay.

    Science.gov (United States)

    Abdelshafi, Nahla A; Panne, Ulrich; Schneider, Rudolf J

    2017-04-01

    This study focused on quantitative detection of cocaine on Euro banknotes in Germany. A sensitive direct competitive immunoassay was developed and optimized with a limit of detection (LOD) of 5.6ng/L. Exhaustive cocaine extraction by solvent was tested using different methanol concentrations and buffered solutions. Cross-reactivity studies were performed to determine the degree of interference of cocaine metabolites with the immunoassay. Sixty-five Euro banknotes obtained from different districts in Berlin were evaluated. A 100% contamination frequency with cocaine was detected. A comparison between the amount of cocaine extracted by cotton swabbing of one square centimeter of the banknote showed a good correlation for lower contamination levels. This assay showed high sensitivity of detecting pg of cocaine per 1cm 2 of one banknote by swabbing 1cm 2 : 0, 14, and 21pg/cm 2 . Moreover, three notes of different denominations revealed high cocaine concentration; 1.1mg/note, and twice 55µg/note. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. BODIPY-based fluorometric sensor array for the highly sensitive identification of heavy-metal ions.

    Science.gov (United States)

    Niu, Li-Ya; Li, Hui; Feng, Liang; Guan, Ying-Shi; Chen, Yu-Zhe; Duan, Chun-Feng; Wu, Li-Zhu; Guan, Ya-Feng; Tung, Chen-Ho; Yang, Qing-Zheng

    2013-05-02

    A BODIPY(4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)-based fluorometric sensor array has been developed for the highly sensitive detection of eight heavy-metal ions at micromolar concentration. The di-2-picolyamine (DPA) derivatives combine high affinities for a variety of heavy-metal ions with the capacity to perturb the fluorescence properties of BODIPY, making them perfectly suitable for the design of fluorometric sensor arrays for heavy-metal ions. 12 cross-reactive BODIPY fluorescent indicators provide facile identification of the heavy-metal ions using a standard chemometric approach (hierarchical clustering analysis); no misclassifications were found over 45 trials. Clear differentiation among heavy-metal ions as a function of concentration was also achieved, even down to 10(-7)M. A semi-quantitative interpolation of the heavy-metal concentration is obtained by comparing the total Euclidean distance of the measurement with a set of known concentrations in the library. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Integrating printed microfluidics with silicon photomultipliers for miniaturised and highly sensitive ATP bioluminescence detection.

    Science.gov (United States)

    Santangelo, M F; Libertino, S; Turner, A P F; Filippini, D; Mak, W C

    2018-01-15

    Bioluminescence has been widely used for important biosensing applications such as the measurement of adenosine triphosphate (ATP), the energy unit in biological systems and an indicator of vital processes. The current technology for detection is mainly based on large equipment such as readers and imaging systems, which require intensive and time-consuming procedures. A miniaturised bioluminescence sensing system, which would allow sensitive and continuous monitoring of ATP, with an integrated and low-cost disposable microfluidic chamber for handling of biological samples, is highly desirable. Here, we report the design, fabrication and testing of 3D printed microfluidics chips coupled with silicon photomultipliers (SiPMs) for high sensitive real-time ATP detection. The 3D microfluidic chip reduces reactant consumption and facilitates solution delivery close to the SiPM to increase the detection efficiency. Our system detects ATP with a limit of detection (LoD) of 8nM and an analytical dynamic range between 15nM and 1µM, showing a stability error of 3%, and a reproducibility error below of 20%. We demonstrate the dynamic monitoring of ATP in a continuous-flow system exhibiting a fast response time, ~4s, and a full recovery to the baseline level within 17s. Moreover, the SiPM-based bioluminescence sensing system shows a similar analytical dynamic range for ATP detection to that of a full-size PerkinElmer laboratory luminescence reader. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Development of High Temperature/High Sensitivity Novel Chemical Resistive Sensor

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Chunrui [Univ. of Texas, San Antonio, TX (United States); Enriquez, Erik [Univ. of Texas, San Antonio, TX (United States); Wang, Haibing [Univ. of Texas, San Antonio, TX (United States); Xu, Xing [Univ. of Texas, San Antonio, TX (United States); Bao, Shangyong [Univ. of Texas, San Antonio, TX (United States); Collins, Gregory [Univ. of Texas, San Antonio, TX (United States)

    2013-08-13

    The research has been focused to design, fabricate, and develop high temperature/high sensitivity novel multifunctional chemical sensors for the selective detection of fossil energy gases used in power and fuel systems. By systematically studying the physical properties of the LnBaCo2O5+d (LBCO) [Ln=Pr or La] thin-films, a new concept chemical sensor based high temperature chemical resistant change has been developed for the application for the next generation highly efficient and near zero emission power generation technologies. We also discovered that the superfast chemical dynamic behavior and an ultrafast surface exchange kinetics in the highly epitaxial LBCO thin films. Furthermore, our research indicates that hydrogen can superfast diffuse in the ordered oxygen vacancy structures in the highly epitaxial LBCO thin films, which suggest that the LBCO thin film not only can be an excellent candidate for the fabrication of high temperature ultra sensitive chemical sensors and control systems for power and fuel monitoring systems, but also can be an excellent candidate for the low temperature solid oxide fuel cell anode and cathode materials.

  11. Highly sensitive three-dimensional interdigitated microelectrode for microparticle detection using electrical impedance spectroscopy

    International Nuclear Information System (INIS)

    Chang, Fu-Yu; Chen, Ming-Kun; Jang, Ling-Sheng; Wang, Min-Haw

    2016-01-01

    Cell impedance analysis is widely used for monitoring biological and medical reactions. In this study, a highly sensitive three-dimensional (3D) interdigitated microelectrode (IME) with a high aspect ratio on a polyimide (PI) flexible substrate was fabricated for microparticle detection (e.g. cell quantity detection) using electroforming and lithography technology. 3D finite element simulations were performed to compare the performance of the 3D IME (in terms of sensitivity and signal-to-noise ratio) to that of a planar IME for particles in the sensing area. Various quantities of particles were captured in Dulbecco’s modified Eagle medium and their impedances were measured. With the 3D IME, the particles were arranged in the gap, not on the electrode, avoiding the noise due to particle position. For the maximum particle quantities, the results show that the 3D IME has at least 5-fold higher sensitivity than that of the planar IME. The trends of impedance magnitude and phase due to particle quantity were verified using the equivalent circuit model. The impedance (1269 Ω) of 69 particles was used to estimate the particle quantity (68 particles) with 98.6% accuracy using a parabolic regression curve at 500 kHz. (paper)

  12. Generalized Protein Attachment Chemistry for Highly Sensitive Carbon Nanotube-Based Biosensors

    Science.gov (United States)

    Lerner, Mitchell; Pazina, Tatiana; Robinson, Matthew; Johnson, A. T. Charlie

    2012-02-01

    We developed a label free covalent functionalization procedure for attaching proteins to carbon nanotube field effect transistors (CNTFETs). Biomarker proteins are becoming increasingly useful for early diagnosis of disease, ranging from cancer to arthritis to stress. Current clinical immunoassays for measuring patient protein levels are costly and require significant processing time. Using diazonium salts followed by stabilization of carboxylic acid groups, we can attach a variety of proteins to carbon nanotubes as confirmed by atomic force microscopy. Proteins maintain the integrity of their epitope and bind to their corresponding complementary proteins. Carbon nanotube transistors are superior readout elements for such protein binding events due to their speed and comparable scale. Resulting changes in the electronic transport properties of CNTFETs demonstrate a concentration-dependent response. Binding of osteopontin (OPN), a biomarker for prostate cancer, to its complementary single chain variable fragment (scFv) can be detected down to 1 pg/mL with these methods. Moreover, these devices exhibit selectivity for OPN. Such high sensitivity biosensors could be used in parallel to test a single small volume patient sample for any number of potentially ominous biomarker proteins.

  13. Highly Sensitive Multifilament Fiber Strain Sensors with Ultrabroad Sensing Range for Textile Electronics.

    Science.gov (United States)

    Lee, Jaehong; Shin, Sera; Lee, Sanggeun; Song, Jaekang; Kang, Subin; Han, Heetak; Kim, SeulGee; Kim, Seunghoe; Seo, Jungmok; Kim, DaeEun; Lee, Taeyoon

    2018-04-06

    Highly stretchable fiber strain sensors are one of the most important components for various applications in wearable electronics, electronic textiles, and biomedical electronics. Herein, we present a facile approach for fabricating highly stretchable and sensitive fiber strain sensors by embedding Ag nanoparticles into a stretchable fiber with a multifilament structure. The multifilament structure and Ag-rich shells of the fiber strain sensor enable the sensor to simultaneously achieve both a high sensitivity and largely wide sensing range despite its simple fabrication process and components. The fiber strain sensor simultaneously exhibits ultrahigh gauge factors (∼9.3 × 10 5 and ∼659 in the first stretching and subsequent stretching, respectively), a very broad strain-sensing range (450 and 200% for the first and subsequent stretching, respectively), and high durability for more than 10 000 stretching cycles. The fiber strain sensors can also be readily integrated into a glove to control a hand robot and effectively applied to monitor the large volume expansion of a balloon and a pig bladder for an artificial bladder system, thereby demonstrating the potential of the fiber strain sensors as candidates for electronic textiles, wearable electronics, and biomedical engineering.

  14. Use of High Sensitivity GNSS Receiver Doppler Measurements for Indoor Pedestrian Dead Reckoning

    Directory of Open Access Journals (Sweden)

    Gérard Lachapelle

    2013-03-01

    Full Text Available Dead-reckoning (DR algorithms, which use self-contained inertial sensors combined with gait analysis, have proven to be effective for pedestrian navigation purposes. In such DR systems, the primary error is often due to accumulated heading drifts. By tightly integrating global navigation satellite system (GNSS Doppler measurements with DR, such accumulated heading errors can usually be accurately compensated. Under weak signal conditions, high sensitivity GNSS (HSGNSS receivers with block processing techniques are often used, however, the Doppler quality of such receivers is relatively poor due to multipath, fading and signal attenuation. This often limits the benefits of integrating HSGNSS Doppler with DR. This paper investigates the benefits of using Doppler measurements from a novel direct vector HSGNSS receiver with pedestrian dead-reckoning (PDR for indoor navigation. An indoor signal and multipath model is introduced which explains how conventional HSGNSS Doppler measurements are affected by indoor multipath. Velocity and Doppler estimated by using direct vector receivers are introduced and discussed. Real experimental data is processed and analyzed to assess the veracity of proposed method. It is shown when integrating HSGNSS Doppler with PDR algorithm, the proposed direct vector method are more helpful than conventional block processing method for the indoor environments considered herein.

  15. Importance of peak PRA in predicting the kidney transplant survival in highly sensitized patients.

    Science.gov (United States)

    Singh, D; Kiberd, B A; West, K A; Kamal, K; Balbontin, F; Belitsky, P; Lawen, J

    2003-11-01

    Do patients with high historic peak panel-reactive antibodies (PRA) remain high risk if their PRA levels fall before transplantation? We examined retrospectively 406 first and repeat kidney recipients with a peak PRA of >50%, who were transplanted from our center between January 1990 and December 2001. Univariate analysis by log-rank test was performed for variables that affect graft survival. The factors tested included current PRA, peak PRA, difference between peak and current PRA (DeltaPRA), HLA mismatch, gender, age, transplant number, and donor source. Receiver operator characteristic curves (ROC) were generated to obtain the best cutpoints for current PRA and DeltaPRA. Current PRA (P PRA (P = .0004), and DeltaPRA (P = .0015) were significant predictors by univariate analysis. However, in a multivariate model, peak PRA was not significant. Current PRA (P PRA of 37% were the best cutpoints for separating good and poor outcomes. This study shows that current PRA and DeltaPRA impact on graft survival in highly sensitized (>50%) patients. Sensitized patients with peak PRA >50% who subsequently have a drop in PRA to PRA. A fall in peak PRA of >37% at the time of transplant appears to be of benefit only in those patients who achieve a current PRA of <26%.

  16. High sensitivity detection of selenium by laser excited atomic fluorescence spectrometry using electrothermal atomization

    International Nuclear Information System (INIS)

    Heitmann, U.; Hese, A.; Schoknecht, G.; Gries, W.

    1995-01-01

    The high sensitivity detection of the trace element selenium is reported. The analytical method applied is Laser Excited Atomic Fluorescence Spectrometry using Electrothermal Atomization within a graphite furnace atomizer. For the production of tunable laser radiation in the VUV spectral region a laser system was developed which consists of two dye lasers pumped by a Nd:YAG laser. The laser radiations are subsequently frequency doubled and sum frequency mixed by nonlinear optical KDP or BBO crystals, respectively. The system works with a repetition rate of 20 Hz and provides output energies of up to 100 μJ in the VUV at a pulse duration of 5 ns. The analytical investigations were focused on the detection of selenium in aqueous solutions and samples of human whole blood. From measurements on aqueous standards detection limits of 1.5 ng/l for selenium were obtained, with corresponding absolute detected masses of only 15 fg. The linear dynamic range spanned six orders of magnitude and good precision was achieved. In case of human whole blood samples the recovery was found to be within the range of 96% to 104%. The determination of the selenium content yielded medians of [119.5 ± 17.3] μg/l for 200 frozen blood samples taken in 1988 and [109.1 ± 15.6] μg/l for 103 fresh blood samples. (author)

  17. Highly Sensitive Colorimetric Assay for Determining Fe3+ Based on Gold Nanoparticles Conjugated with Glycol Chitosan

    Directory of Open Access Journals (Sweden)

    Kyungmin Kim

    2017-01-01

    Full Text Available A highly sensitive and simple colorimetric assay for the detection of Fe3+ ions was developed using gold nanoparticles (AuNPs conjugated with glycol chitosan (GC. The Fe3+ ion coordinates with the oxygen atoms of GC in a hexadentate manner (O-Fe3+-O, decreasing the interparticle distance and inducing aggregation. Time-of-flight secondary ion mass spectrometry showed that the bound Fe3+ was coordinated to the oxygen atoms of the ethylene glycol in GC, which resulted in a significant color change from light red to dark midnight blue due to aggregation. Using this GC-AuNP probe, the quantitative determination of Fe3+ in biological, environmental, and pharmaceutical samples could be achieved by the naked eye and spectrophotometric methods. Sensitive response and pronounced color change of the GC-AuNPs in the presence of Fe3+ were optimized at pH 6, 70°C, and 300 mM NaCl concentration. The absorption intensity ratio (A700/A510 linearly correlated to the Fe3+ concentration in the linear range of 0–180 μM. The limits of detection were 11.3, 29.2, and 46.0 nM for tap water, pond water, and iron supplement tablets, respectively. Owing to its facile and sensitive nature, this assay method for Fe3+ ions can be applied to the analysis of drinking water and pharmaceutical samples.

  18. A High Sensitivity Micro Format Chemiluminescence Enzyme Inhibition Assay for Determination of Hg(II

    Directory of Open Access Journals (Sweden)

    Kanchanmala Deshpande

    2010-06-01

    Full Text Available A highly sensitive and specific enzyme inhibition assay based on alcohol oxidase (AlOx and horseradish peroxidase (HRP for determination of mercury Hg(II in water samples has been presented. This article describes the optimization and miniaturization of an enzymatic assay using a chemiluminescence reaction. The analytical performance and detection limit for determination of Hg(II was optimized in 96 well plates and further extended to 384 well plates with a 10-fold reduction in assay volume. Inhibition of the enzyme activity by dissolved Hg(II was found to be linear in the range 5–500 pg.mL−1 with 3% CVin inter-batch assay. Due to miniaturization of assay in 384 well plates, Hg(II was measurable as low as 1 pg.mL−1 within15 min. About 10-fold more specificity of the developed assay for Hg(II analysis was confirmed by challenging with interfering divalent metal ions such as cadmium Cd(II and lead Pb(II. Using the proposed assay we could successfully demonstrate that in a composite mixture of Hg(II, Cd(II and Pb(II, inhibition by each metal ion is significantly enhanced in the presence of the others. Applicability of the proposed assay for the determination of the Hg(II in spiked drinking and sea water resulted in recoveries ranging from 100–110.52%.

  19. Sub-picometer multi-wavelength detector based on highly sensitive nanomechanical resonator

    Science.gov (United States)

    Maeda, Etsuo; Kometani, Reo

    2017-07-01

    The wavelength division multiplexing (WDM) method for near infrared (NIR) optical fiber (1530-1565 nm) is the system that is wildly used for intercontinental communication. WDM achieves high-speed and large-capacity communication, but costs a lot because the high-resolution (˜10 pm) wavelength locker for wavelength stabilization only corresponds to a single wavelength. In this report, we propose a highly sensitive sub-picometer multi-wavelength detector that substitutes a typical single-wavelength detector for WDM. Our wavelength detector consists of a narrow band (FWHM 20 000) nanomechanical resonator. The photonic absorber confines and transforms the illuminated NIR light wave into thermal stress, and then, the thermal stress in the nanomechanical resonator will appear as the eigenfrequency shift of the nanomechanical resonator. Through experimental works with an NIR laser and optical Doppler vibration meter, the sensitivity of our wavelength detector was determined to be 0.196 pm in the 10-nm-range of the NIR region. Our sub-picometer multi-wavelength detector will achieve a fast, wide-band, and cost-effective optical communication system.

  20. Highly sensitive single polyaniline nanowire biosensor for the detection of immunoglobulin G and myoglobin

    Science.gov (United States)

    Lee, Innam; Luo, Xiliang; Cui, Xinyan Tracy; Yun, Minhee

    2011-01-01

    A single polyaniline (PANI) nanowire-based biosensor was established to detect immunoglobulin G (IgG) and myoglobin (Myo), which is one of the cardiac biomarkers. The single PANI nanowires were fabricated via an electrochemical growth method, in which single nanowires were formed between a pair of patterned electrodes. The single PANI nanowires were functionalized with monoclonal antibodies (mAbs) of IgG or Myo via a surface immobilization method, using 1-ethyl-3-(3-dimethyaminopropyl) carbodiimide (EDC), and N-Hydroxysuccinimde (NHS). The functionalization was then verified by Raman spectroscopy and fluorescence microscopy. The target proteins of IgG and Myo were detected by measuring the conductance change of functionalized single PANI nanowires owing to the capturing of target proteins by mAbs. The detection limit was found to be 3 ng/mL for IgG and 1.4 ng/mL for Myo. No response was observed when single nanowires were exposed to a non-specific protein demonstrating excellent specificity to expected target detection. Together with the fast response time (a few seconds), high sensitivity, and good specificity, this single PANI nanowire-based biosensor shows great promise in the detection of cardiac markers and other proteins. PMID:21269820

  1. High-sensitivity four-layer polymer fiber-optic evanescent wave sensor.

    Science.gov (United States)

    Xin, Xin; Zhong, Nianbing; Liao, Qiang; Cen, Yanyan; Wu, Ruohua; Wang, Zhengkun

    2017-05-15

    We present a novel four-layer structure consisting of bottom, second, third, and surface layers in the sensing region, for a D-shaped step-index fiber-optic evanescent wave (FOEW) sensor. To reduce the background noise, the surface of the longitudinal section in the D-shaped region is coated with a light-absorbing film. We check the morphologies of the second and surface layers, examine the refractive indices (RIs) of the third and surface layers, and analyze the composition of the surface layer. We also investigate the effects of the thicknesses and RIs of the third and surface layers and the LA film on the light transmission and sensitivity of the FOEW sensors. The results highlight the very good sensitivity of the proposed FOEW sensor with a four-layer structure, which reached -0.077 (μg/l) -1 in the detection of the target antibody; the sensitivity of the novel FOEW sensor was 7.60 and 1.52 times better than that of a conventional sensor with a core-cladding structure and an FOEW sensor with a three-layer structure doped with GeO 2 . The applications of this high-sensitivity FOEW sensor can be extended to biodefense, disease diagnosis, and biomedical and biochemical analysis. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. A Monolithic CMOS Magnetic Hall Sensor with High Sensitivity and Linearity Characteristics

    Directory of Open Access Journals (Sweden)

    Haiyun Huang

    2015-10-01

    Full Text Available This paper presents a fully integrated linear Hall sensor by means of 0.8 μm high voltage complementary metal-oxide semiconductor (CMOS technology. This monolithic Hall sensor chip features a highly sensitive horizontal switched Hall plate and an efficient signal conditioner using dynamic offset cancellation technique. An improved cross-like Hall plate achieves high magnetic sensitivity and low offset. A new spinning current modulator stabilizes the quiescent output voltage and improves the reliability of the signal conditioner. The tested results show that at the 5 V supply voltage, the maximum Hall output voltage of the monolithic Hall sensor microsystem, is up to ±2.1 V and the linearity of Hall output voltage is higher than 99% in the magnetic flux density range from ±5 mT to ±175 mT. The output equivalent residual offset is 0.48 mT and the static power consumption is 20 mW.

  3. Haemocompatibility of iron oxide nanoparticles synthesized for theranostic applications: a high-sensitivity microfluidic tool

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Raquel O. [Polytechnic Institute of Bragança, Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials (LSRE-LCM) (Portugal); Bañobre-López, Manuel; Gallo, Juan [INL-International Iberian Nanotechnology Laboratory, Advanced (Magnetic) Theranostic Nanostructures Lab (Portugal); Tavares, Pedro B. [Universidade de Trás-os-Montes e Alto Douro, CQVR-Centro de Química-Vila Real (Portugal); Silva, Adrián M. T. [Universidade do Porto, Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials (LSRE-LCM), Faculdade de Engenharia (Portugal); Lima, Rui, E-mail: rl@dem.uminho.pt [MEtRiCS, University of Minho, Mechanical Engineering Department (Portugal); Gomes, Helder T. [Polytechnic Institute of Bragança, Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials (LSRE-LCM) (Portugal)

    2016-07-15

    The poor heating efficiency of the most reported magnetic nanoparticles (MNPs), allied to the lack of comprehensive biocompatibility and haemodynamic studies, hampers the spread of multifunctional nanoparticles as the next generation of therapeutic bio-agents in medicine. The present work reports the synthesis and characterization, with special focus on biological/toxicological compatibility, of superparamagnetic nanoparticles with diameter around 18 nm, suitable for theranostic applications (i.e. simultaneous diagnosis and therapy of cancer). Envisioning more insights into the complex nanoparticle-red blood cells (RBCs) membrane interaction, the deformability of the human RBCs in contact with magnetic nanoparticles (MNPs) was assessed for the first time with a microfluidic extensional approach, and used as an indicator of haematological disorders in comparison with a conventional haematological test, i.e. the haemolysis analysis. Microfluidic results highlight the potential of this microfluidic tool over traditional haemolysis analysis, by detecting small increments in the rigidity of the blood cells, when traditional haemotoxicology analysis showed no significant alteration (haemolysis rates lower than 2 %). The detected rigidity has been predicted to be due to the wrapping of small MNPs by the bilayer membrane of the RBCs, which is directly related to MNPs size, shape and composition. The proposed microfluidic tool adds a new dimension into the field of nanomedicine, allowing to be applied as a high-sensitivity technique capable of bringing a better understanding of the biological impact of nanoparticles developed for clinical applications.

  4. Toward achieving flexible and high sensitivity hexagonal boron nitride neutron detectors

    Science.gov (United States)

    Maity, A.; Grenadier, S. J.; Li, J.; Lin, J. Y.; Jiang, H. X.

    2017-07-01

    Hexagonal boron nitride (h-BN) detectors have demonstrated the highest thermal neutron detection efficiency to date among solid-state neutron detectors at about 51%. We report here the realization of h-BN neutron detectors possessing one order of magnitude enhancement in the detection area but maintaining an equal level of detection efficiency of previous achievement. These 3 mm × 3 mm detectors were fabricated from 50 μm thick freestanding and flexible 10B enriched h-BN (h-10BN) films, grown by metal organic chemical vapor deposition followed by mechanical separation from sapphire substrates. Mobility-lifetime results suggested that holes are the majority carriers in unintentionally doped h-BN. The detectors were tested under thermal neutron irradiation from californium-252 (252Cf) moderated by a high density polyethylene moderator. A thermal neutron detection efficiency of ˜53% was achieved at a bias voltage of 200 V. Conforming to traditional solid-state detectors, the realization of h-BN epilayers with enhanced electrical transport properties is the key to enable scaling up the device sizes. More specifically, the present results revealed that achieving an electrical resistivity of greater than 1014 Ωṡcm and a leakage current density of below 3 × 10-10 A/cm2 is needed to fabricate large area h-BN detectors and provided guidance for achieving high sensitivity solid state neutron detectors based on h-BN.

  5. Application of a novel highly sensitive activity-based probe for detection of cathepsin G.

    Science.gov (United States)

    Zou, Fang; Schmon, Michael; Sienczyk, Marcin; Grzywa, Renata; Palesch, David; Boehm, Bernhard O; Sun, Zi Lin; Watts, Colin; Schirmbeck, Reinhold; Burster, Timo

    2012-02-15

    Cathepsins are crucial in antigen processing in the major histocompatibility complex class II (MHC II) pathway. Within the proteolytic machinery, three classes of proteases (i.e., cysteine, aspartic, and serine proteases) are present in the endocytic compartments. The combined action of these proteases generates antigenic peptides from antigens, which are loaded to MHC II molecules for CD4+ T cell presentation. Detection of active serine proteases in primary human antigen-presenting cells (APCs) is restricted because of the small numbers of cells isolated from the peripheral blood. For this purpose, we developed a novel highly sensitive α-aminoalkylphosphonate diphenyl ester (DAP) activity-based probe to detect the serine protease cathepsin G (CatG) in primary APCs and after Epstein-Barr virus (EBV) exposure. Although CatG activity was not altered after short-term exposure of EBV in primary myeloid dendritic cells 1 (mDC1s), the aspartic protease cathepsin D (CatD) was reduced, suggesting that EBV is responsible for mitigating the presentation of a model antigen tetanus toxoid C-fragment (TTCF) by reduction of CatD. In addition, CatG activity was reduced to background levels in B cells during cell culture; however, these findings were independent of EBV transformation. In conclusion, our activity-based probe can be used for both Western blot and 96-well-based high-throughput CatG detection when cell numbers are limited. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Highly sensitive and stable electrochemical sulfite biosensor incorporating a bacterial sulfite dehydrogenase.

    Science.gov (United States)

    Kalimuthu, Palraj; Tkac, Jan; Kappler, Ulrike; Davis, Jason J; Bernhardt, Paul V

    2010-09-01

    This paper describes a highly sensitive electrochemical (voltammetric) determination of sulfite using a combination of Starkeya novella sulfite dehydrogenase (SDH), horse heart cytochrome c (cyt c), and a self-assembled monolayer of 11-mercaptoundecanol (MU) cast on a gold electrode. The biosensor was optimized in terms of pH and the ratio of cyt c/SDH. The electrocatalytic oxidation current of sulfite increased linearly from 1 to 6 microM at the enzyme-modified electrode with a correlation coefficient of 0.9995 and an apparent Michaelis constant (K(M,app)) of 43 microM. Using an amperometric method, the low detection limit for sulfite at the enzyme-modified electrode was 44 pM (signal-to-noise ratio = 3). The modified electrode retained a stable response for 3 days while losing only ca. 4% of its initial sensitivity during a 2 week storage period in 50 mM Tris buffer solution at 4 degrees C. The enzyme electrode was successfully used for the determination of sulfite in beer and white wine samples. The results of these electrochemical analyses agreed well with an independent spectrophotometric method using Ellman's reagent, but the detection limit was far superior using the electrochemical method.

  7. Rapid and highly sensitive detection of Enterovirus 71 by using nanogold-enhanced electrochemical impedance spectroscopy

    International Nuclear Information System (INIS)

    Li, Hsing-Yuan; Tseng, Shing-Hua; Cheng, Tsai-Mu; Chu, Hsueh-Liang; Lu, Yu-Ning; Wang, Fang-Yu; Tu, Lung-Chen; Chang, Chia-Ching; Tsai, Li-Yun; Shieh, Juo-Yu; Yang, Jyh-Yuan; Juan, Chien-Chang

    2013-01-01

    Enterovirus 71 (EV71) infection is an emerging infectious disease causing neurological complications and/or death within two to three days after the development of fever and rash. A low viral titre in clinical specimens makes the detection of EV71 difficult. Conventional approaches for detecting EV71 are time consuming, poorly sensitive, or complicated, and cannot be used effectively for clinical diagnosis. Furthermore, EV71 and Coxsackie virus A16 (CA16) may cross react in conventional assays. Therefore, a rapid, highly sensitive, specific, and user-friendly test is needed. We developed an EV71-specific nanogold-modified working electrode for electrochemical impedance spectroscopy in the detection of EV71. Our results show that EV71 can be distinguished from CA16, Herpes simplex virus, and lysozyme, with the modified nanogold electrode being able to detect EV71 in concentrations as low as 1 copy number/50 μl reaction volume, and the duration between sample preparation and detection being 11 min. This detection platform may have the potential for use in point-of-care diagnostics. (paper)

  8. High sensitivity and label-free detection of Enterovirus 71 by nanogold modified electrochemical impedance spectroscopy

    Science.gov (United States)

    Wang, Fang-Yu; Li, Hsing-Yuan; Tseng, Shing-Hua; Cheng, Tsai-Mu; Chu, Hsueh-Liang; Yang, Jyh-Yuan; Chang, Chia-Ching

    2013-03-01

    Enterovirus 71 (EV71), which is the most fulminant and invasive species of enterovirus, can cause children neurologic complications and death within 2-3 days after fever and rash developed. Besides, EV71 has high sequence similarity with Coxsackie A 16 (CA16) that makes differential diagnosis difficult in clinic and laboratory. Since conventional viral diagnostic method cannot diagnose EV71 quickly and EV71 can transmit at low viral titer, the patients might delay in treatment. A quick, high sensitive, and high specific test for EV71 detection is pivotal. Electrochemical impedance spectroscopy (EIS) has been applied for detecting bio-molecules as biosensors recently. In this study, we try to build a detection platform for EV71 detection by nanogold modified EIS probe. The result shows that our probe can detect 3.6 VP1/50 μl (one EV71 particle has 60 VP1) in 3 minutes. The test can also distinguish EV71 from CA16 and lysozyme. Diagnosis of enterovirus 71 by electrochemical impedance spectroscopy has the potential to apply in clinic.

  9. Rapid and highly sensitive detection of Enterovirus 71 by using nanogold-enhanced electrochemical impedance spectroscopy

    Science.gov (United States)

    Li, Hsing-Yuan; Tseng, Shing-Hua; Cheng, Tsai-Mu; Chu, Hsueh-Liang; Lu, Yu-Ning; Wang, Fang-Yu; Tsai, Li-Yun; Shieh, Juo-Yu; Yang, Jyh-Yuan; Juan, Chien-Chang; Tu, Lung-Chen; Chang, Chia-Ching

    2013-07-01

    Enterovirus 71 (EV71) infection is an emerging infectious disease causing neurological complications and/or death within two to three days after the development of fever and rash. A low viral titre in clinical specimens makes the detection of EV71 difficult. Conventional approaches for detecting EV71 are time consuming, poorly sensitive, or complicated, and cannot be used effectively for clinical diagnosis. Furthermore, EV71 and Coxsackie virus A16 (CA16) may cross react in conventional assays. Therefore, a rapid, highly sensitive, specific, and user-friendly test is needed. We developed an EV71-specific nanogold-modified working electrode for electrochemical impedance spectroscopy in the detection of EV71. Our results show that EV71 can be distinguished from CA16, Herpes simplex virus, and lysozyme, with the modified nanogold electrode being able to detect EV71 in concentrations as low as 1 copy number/50 μl reaction volume, and the duration between sample preparation and detection being 11 min. This detection platform may have the potential for use in point-of-care diagnostics.

  10. A highly sensitive, low-cost, wearable pressure sensor based on conductive hydrogel spheres

    KAUST Repository

    Tai, Yanlong

    2015-01-01

    Wearable pressure sensing solutions have promising future for practical applications in health monitoring and human/machine interfaces. Here, a highly sensitive, low-cost, wearable pressure sensor based on conductive single-walled carbon nanotube (SWCNT)/alginate hydrogel spheres is reported. Conductive and piezoresistive spheres are embedded between conductive electrodes (indium tin oxide-coated polyethylene terephthalate films) and subjected to environmental pressure. The detection mechanism is based on the piezoresistivity of the SWCNT/alginate conductive spheres and on the sphere-electrode contact. Step-by-step, we optimized the design parameters to maximize the sensitivity of the sensor. The optimized hydrogel sensor exhibited a satisfactory sensitivity (0.176 ΔR/R0/kPa-1) and a low detectable limit (10 Pa). Moreover, a brief response time (a few milliseconds) and successful repeatability were also demonstrated. Finally, the efficiency of this strategy was verified through a series of practical tests such as monitoring human wrist pulse, detecting throat muscle motion or identifying the location and the distribution of an external pressure using an array sensor (4 × 4). © 2015 The Royal Society of Chemistry.

  11. A High Sensitivity IDC-Electronic Tongue Using Dielectric/Sensing Membranes with Solvatochromic Dyes

    Directory of Open Access Journals (Sweden)

    Md. Rajibur Rahaman Khan

    2016-05-01

    Full Text Available In this paper, an electronic tongue/taste sensor array containing different interdigitated capacitor (IDC sensing elements to detect different types of tastes, such as sweetness (glucose, saltiness (NaCl, sourness (HCl, bitterness (quinine-HCl, and umami (monosodium glutamate is proposed. We present for the first time an IDC electronic tongue using sensing membranes containing solvatochromic dyes. The proposed highly sensitive (30.64 mV/decade sensitivity IDC electronic tongue has fast response and recovery times of about 6 s and 5 s, respectively, with extremely stable responses, and is capable of linear sensing performance (R2 ≈ 0.985 correlation coefficient over the wide dynamic range of 1 µM to 1 M. The designed IDC electronic tongue offers excellent reproducibility, with a relative standard deviation (RSD of about 0.029. The proposed device was found to have better sensing performance than potentiometric-, cascoded compatible lateral bipolar transistor (C-CLBT-, Electronic Tongue (SA402-, and fiber-optic-based taste sensing systems in what concerns dynamic range width, response time, sensitivity, and linearity. Finally, we applied principal component analysis (PCA to distinguish between various kinds of taste in mixed taste compounds.

  12. Passive Aerial Grasping of Ferrous Objects

    KAUST Repository

    Fiaz, Usman Amin

    2017-10-19

    Aerial transportation is probably the most efficient way to supply quick and effective aid especially in cases of emergency like search and rescue operations. Thus the ability to grasp and deliver objects is of vital importance in all sorts of unmanned and autonomous aerial operations. We detail a simple yet novel approach for aerial grasping of ferrous objects using a passive magnetic pickup and an impulse based drop mechanism. The design enables our gripper to grasp ferrous objects using single as well as multiple gripping pads, with visual as well as pickup and drop feedback. We describe the various components of the gripper with emphasis on its low mass and high lift capability since weight is a matter of high consideration in all aerial applications. In addition, we investigate and address the issues that may cause our design to fail. We demonstrate by experiments that the proposed design is robust and effective, based on its high payload capability, its sturdiness against possible slide during aggressive aerial maneuvers, and optimum performance of the drop mechanism for the designed range of payloads. We also show that the gripper is able to pick up and drop a single as well as multiple ferrous objects of different shapes, curvature, and inclination, which also involves picking up an object and then grasping the next, while keeping hold of the previous one.

  13. Looking for an old aerial photograph

    Science.gov (United States)

    ,

    1997-01-01

    Attempts to photograph the surface of the Earth date from the 1800's, when photographers attached cameras to balloons, kites, and even pigeons. Today, aerial photographs and satellite images are commonplace. The rate of acquiring aerial photographs and satellite images has increased rapidly in recent years. Views of the Earth obtained from aircraft or satellites have become valuable tools to Government resource planners and managers, land-use experts, environmentalists, engineers, scientists, and a wide variety of other users. Many people want historical aerial photographs for business or personal reasons. They may want to locate the boundaries of an old farm or a piece of family property. Or they may want a photograph as a record of changes in their neighborhood, or as a gift. The U.S. Geological Survey (USGS) maintains the Earth Science Information Centers (ESIC?s) to sell aerial photographs, remotely sensed images from satellites, a wide array of digital geographic and cartographic data, as well as the Bureau?s wellknown maps. Declassified photographs from early spy satellites were recently added to the ESIC offerings of historical images. Using the Aerial Photography Summary Record System database, ESIC researchers can help customers find imagery in the collections of other Federal agencies and, in some cases, those of private companies that specialize in esoteric products.

  14. Cooperative path planning of unmanned aerial vehicles

    CERN Document Server

    Tsourdos, Antonios; Shanmugavel, Madhavan

    2010-01-01

    An invaluable addition to the literature on UAV guidance and cooperative control, Cooperative Path Planning of Unmanned Aerial Vehicles is a dedicated, practical guide to computational path planning for UAVs. One of the key issues facing future development of UAVs is path planning: it is vital that swarm UAVs/ MAVs can cooperate together in a coordinated manner, obeying a pre-planned course but able to react to their environment by communicating and cooperating. An optimized path is necessary in order to ensure a UAV completes its mission efficiently, safely, and successfully. Focussing on the path planning of multiple UAVs for simultaneous arrival on target, Cooperative Path Planning of Unmanned Aerial Vehicles also offers coverage of path planners that are applicable to land, sea, or space-borne vehicles. Cooperative Path Planning of Unmanned Aerial Vehicles is authored by leading researchers from Cranfield University and provides an authoritative resource for researchers, academics and engineers working in...

  15. The Development and Flight Testing of an Aerially Deployed Unmanned Aerial System

    Science.gov (United States)

    Smith, Andrew

    An investigation into the feasibility of aerial deployed unmanned aerial vehicles was completed. The investigation included the development and flight testing of multiple unmanned aerial systems to investigate the different components of potential aerial deployment missions. The project consisted of two main objectives; the first objective dealt with the development of an airframe capable of surviving aerial deployment from a rocket and then self assembling from its stowed configuration into its flight configuration. The second objective focused on the development of an autopilot capable of performing basic guidance, navigation, and control following aerial deployment. To accomplish these two objectives multiple airframes were developed to verify their completion experimentally. The first portion of the project, investigating the feasibility of surviving an aerial deployment, was completed using a fixed wing glider that following a successful deployment had 52 seconds of controlled flight. Before developing the autopilot in the second phase of the project, the glider was significantly upgraded to fix faults discovered in the glider flight testing and to enhance the system capabilities. Unfortunately to conform to outdoor flight restrictions imposed by the university and the Federal Aviation Administration it was required to switch airframes before flight testing of the new fixed wing platform could begin. As a result, an autopilot was developed for a quadrotor and verified experimentally completely indoors to remain within the limits of governing policies.

  16. Highly sensitive detection of DNA methylation levels by using a quantum dot-based FRET method

    Science.gov (United States)

    Ma, Yunfei; Zhang, Honglian; Liu, Fangming; Wu, Zhenhua; Lu, Shaohua; Jin, Qinghui; Zhao, Jianlong; Zhong, Xinhua; Mao, Hongju

    2015-10-01

    DNA methylation is the most frequently studied epigenetic modification that is strongly involved in genomic stability and cellular plasticity. Aberrant changes in DNA methylation status are ubiquitous in human cancer and the detection of these changes can be informative for cancer diagnosis. Herein, we reported a facile quantum dot-based (QD-based) fluorescence resonance energy transfer (FRET) technique for the detection of DNA methylation. The method relies on methylation-sensitive restriction enzymes for the differential digestion of genomic DNA based on its methylation status. Digested DNA is then subjected to PCR amplification for the incorporation of Alexa Fluor-647 (A647) fluorophores. DNA methylation levels can be detected qualitatively through gel analysis and quantitatively by the signal amplification from QDs to A647 during FRET. Furthermore, the methylation levels of three tumor suppressor genes, PCDHGB6, HOXA9 and RASSF1A, in 20 lung adenocarcinoma and 20 corresponding adjacent nontumorous tissue (NT) samples were measured to verify the feasibility of the QD-based FRET method and a high sensitivity for cancer detection (up to 90%) was achieved. Our QD-based FRET method is a convenient, continuous and high-throughput method, and is expected to be an alternative for detecting DNA methylation as a biomarker for certain human cancers.DNA methylation is the most frequently studied epigenetic modification that is strongly involved in genomic stability and cellular plasticity. Aberrant changes in DNA methylation status are ubiquitous in human cancer and the detection of these changes can be informative for cancer diagnosis. Herein, we reported a facile quantum dot-based (QD-based) fluorescence resonance energy transfer (FRET) technique for the detection of DNA methylation. The method relies on methylation-sensitive restriction enzymes for the differential digestion of genomic DNA based on its methylation status. Digested DNA is then subjected to PCR

  17. Effects of sponsorship disclosure timing on the processing of sponsored content: a study on the effectiveness of European disclosure regulations

    NARCIS (Netherlands)

    Boerman, S.C.; van Reijmersdal, E.A.; Neijens, P.C.

    2014-01-01

    This study investigates whether the timing of sponsorship disclosure affects viewers’ processing of sponsored content, and whether a disclosure influences the persuasive effect of the sponsored content. A model is proposed in which sponsorship disclosure enhances the recognition of sponsored

  18. Design optimization of structural parameters for highly sensitive photonic crystal label-free biosensors.

    Science.gov (United States)

    Ju, Jonghyun; Han, Yun-ah; Kim, Seok-min

    2013-03-07

    The effects of structural design parameters on the performance of nano-replicated photonic crystal (PC) label-free biosensors were examined by the analysis of simulated reflection spectra of PC structures. The grating pitch, duty, scaled grating height and scaled TiO2 layer thickness were selected as the design factors to optimize the PC structure. The peak wavelength value (PWV), full width at half maximum of the peak, figure of merit for the bulk and surface sensitivities, and surface/bulk sensitivity ratio were also selected as the responses to optimize the PC label-free biosensor performance. A parametric study showed that the grating pitch was the dominant factor for PWV, and that it had low interaction effects with other scaled design factors. Therefore, we can isolate the effect of grating pitch using scaled design factors. For the design of PC-label free biosensor, one should consider that: (1) the PWV can be measured by the reflection peak measurement instruments, (2) the grating pitch and duty can be manufactured using conventional lithography systems, and (3) the optimum design is less sensitive to the grating height and TiO2 layer thickness variations in the fabrication process. In this paper, we suggested a design guide for highly sensitive PC biosensor in which one select the grating pitch and duty based on the limitations of the lithography and measurement system, and conduct a multi objective optimization of the grating height and TiO2 layer thickness for maximizing performance and minimizing the influence of parameter variation. Through multi-objective optimization of a PC structure with a fixed grating height of 550 nm and a duty of 50%, we obtained a surface FOM of 66.18 RIU-1 and an S/B ratio of 34.8%, with a grating height of 117 nm and TiO2 height of 210 nm.

  19. High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity

    International Nuclear Information System (INIS)

    Mitra, Mayurranjan S.; Donthamsetty, Shashikiran; White, Brent; Mehendale, Harihara M.

    2008-01-01

    Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investigated whether a physiological intervention by feeding 40% high fat diet (HFD), which induces obesity in male Sprague-Dawley rats (250-275 g), sensitizes to doxorubicin-induced cardiotoxicity. A LD 10 dose (8 mg doxorubicin/kg, ip) administered on day 43 of the HFD feeding regimen led to higher cardiotoxicity, cardiac dysfunction, lipid peroxidation, and 80% mortality in the obese (OB) rats in the absence of any significant renal or hepatic toxicity. Doxorubicin toxicokinetics studies revealed no change in accumulation of doxorubicin and doxorubicinol (toxic metabolite) in the normal diet-fed (ND) and OB hearts. Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-α, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9 ± 14.0 nmol/min/g heart in ND versus 400.2 ± 11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-α2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration. Decreased cardiac erythropoietin and increased SOCS3 further downregulated the cardioprotective JAK/STAT3 pathway. In conclusion, HFD-induced obese rats are highly sensitized to doxorubicin-induced cardiotoxicity by substantially downregulating cardiac mitochondrial ATP generation, increasing oxidative stress and downregulating the JAK/STAT3

  20. The parallel reaction monitoring method contributes to a highly sensitive polyubiquitin chain quantification

    Energy Technology Data Exchange (ETDEWEB)

    Tsuchiya, Hikaru; Tanaka, Keiji, E-mail: tanaka-kj@igakuken.or.jp; Saeki, Yasushi, E-mail: saeki-ys@igakuken.or.jp

    2013-06-28

    Highlights: •The parallel reaction monitoring method was applied to ubiquitin quantification. •The ubiquitin PRM method is highly sensitive even in biological samples. •Using the method, we revealed that Ufd4 assembles the K29-linked ubiquitin chain. -- Abstract: Ubiquitylation is an essential posttranslational protein modification that is implicated in a diverse array of cellular functions. Although cells contain eight structurally distinct types of polyubiquitin chains, detailed function of several chain types including K29-linked chains has remained largely unclear. Current mass spectrometry (MS)-based quantification methods are highly inefficient for low abundant atypical chains, such as K29- and M1-linked chains, in complex mixtures that typically contain highly abundant proteins. In this study, we applied parallel reaction monitoring (PRM), a quantitative, high-resolution MS method, to quantify ubiquitin chains. The ubiquitin PRM method allows us to quantify 100 attomole amounts of all possible ubiquitin chains in cell extracts. Furthermore, we quantified ubiquitylation levels of ubiquitin-proline-β-galactosidase (Ub-P-βgal), a historically known model substrate of the ubiquitin fusion degradation (UFD) pathway. In wild-type cells, Ub-P-βgal is modified with ubiquitin chains consisting of 21% K29- and 78% K48-linked chains. In contrast, K29-linked chains are not detected in UFD4 knockout cells, suggesting that Ufd4 assembles the K29-linked ubiquitin chain(s) on Ub-P-βgal in vivo. Thus, the ubiquitin PRM is a novel, useful, quantitative method for analyzing the highly complicated ubiquitin system.

  1. An Improved High-Sensitivity Airborne Transient Electromagnetic Sensor for Deep Penetration.

    Science.gov (United States)

    Chen, Shudong; Guo, Shuxu; Wang, Haofeng; He, Miao; Liu, Xiaoyan; Qiu, Yu; Zhang, Shuang; Yuan, Zhiwen; Zhang, Haiyang; Fang, Dong; Zhu, Jun

    2017-01-17

    The investigation depth of transient electromagnetic sensors can be effectively increased by reducing the system noise, which is mainly composed of sensor internal noise, electromagnetic interference (EMI), and environmental noise, etc. A high-sensitivity airborne transient electromagnetic (AEM) sensor with low sensor internal noise and good shielding effectiveness is of great importance for deep penetration. In this article, the design and optimization of such an AEM sensor is described in detail. To reduce sensor internal noise, a noise model with both a damping resistor and a preamplifier is established and analyzed. The results indicate that a sensor with a large diameter, low resonant frequency, and low sampling rate will have lower sensor internal noise. To improve the electromagnetic compatibility of the sensor, an electromagnetic shielding model for a central-tapped coil is established and discussed in detail. Previous studies have shown that unclosed shields with multiple layers and center grounding can effectively suppress EMI and eddy currents. According to these studies, an improved differential AEM sensor is constructed with a diameter, resultant effective area, resonant frequency, and normalized equivalent input noise of 1.1 m, 114 m², 35.6 kHz, and 13.3 nV/m², respectively. The accuracy of the noise model and the shielding effectiveness of the sensor have been verified experimentally. The results show a good agreement between calculated and measured results for the sensor internal noise. Additionally, over 20 dB shielding effectiveness is achieved in a complex electromagnetic environment. All of these results show a great improvement in sensor internal noise and shielding effectiveness.

  2. Acute kidney injury induces high-sensitivity troponin measurement changes after cardiac surgery.

    Science.gov (United States)

    Omar, Amr S; Mahmoud, Khaled; Hanoura, Samy; Osman, Hany; Sivadasan, Praveen; Sudarsanan, Suraj; Shouman, Yasser; Singh, Rajvir; AlKhulaifi, Abdulaziz

    2017-01-31

    The value of cardiac troponin as a risk assessment tool for cardiac disease in the setting of end-stage renal diseases (ESRD) is not equivalent to its value in those with normal renal function. This consideration had not been studied in settings of acute kidney injury (AKI). We aim to explore the diagnostic value of high sensitive troponin T (hsTnT) in the settings of cardiac surgery-induced AKI. Single center observational retrospective study. Based on the AKI Network, patients divided into 2 groups, group I without AKI (259 patients) and group II with AKI (100 patients) where serial testing of hsTnT and creatine kinase (CK)-MB were followed in both groups. Patients with (ESRD) were excluded. The mean age in our study was 55.1 ± 10.2 years. High association of AKI (27.8%) was found in our patients. Both groups were matched regarding the age, gender, body mass index, the association of diabetes or hypertension, and Euro score. AKI group had significantly higher mortality 5% vs group I 1.1% (p = 0.03). The hsTnt showed a significant sustained rise in the AKI group as compared to the non-AKI group, however CK-MB changes were significant initially but not sustained. The AKI group was more associated with heart failure 17.9% vs 4.9% (p = 0.001); and post-operative atrial fibrillation, 12.4% vs 2.9% (p = 0.005). Lengths of ventilation, stays in ICU and in hospital were significantly higher in the AKI group. Unlike the CK-MB profile, the hsTnT showed significant changes between both groups all over the course denoting possible delayed clearance in patients with AKI.

  3. Diagnostic and prognostic value of high-sensitivity cardiac troponin T in patients with syncope.

    Science.gov (United States)

    Christ, Michael; Geier, Felicitas; Popp, Steffen; Singler, Katrin; Smolarsky, Alexander; Bertsch, Thomas; Müller, Christian; Greve, Yvonne

    2015-02-01

    We examined the diagnostic and predictive value of high-sensitivity cardiac troponin T (cTnThs) in patients with syncope. We performed an analysis of consecutive patients with syncope presenting to the emergency department. The primary end point was the accuracy to diagnose a cardiac syncope. In addition, the study explored the prognostic relevance of cTnThs in patients with cardiac and noncardiac syncope. A total of 360 patients were enrolled (median age, 70.5 years; male, 55.8%; 23.9% aged >80 years). Cardiac syncope was present in 22% of patients, reflex syncope was present in 40% of patients, syncope due to orthostatic hypotension was present in 20% of patients, and unexplained syncope was present in 17.5% of patients. A total of 148 patients (41%) had cTnThs levels above the 99% confidence interval (CI) (cutoff point). The diagnostic accuracy for cTnThs levels to determine the diagnosis of cardiac syncope was quantified by the area under the curve (0.77; CI, 0.72-0.83; P value of cTnThs levels within 30 days: Patients with increased cTnThs levels had a 52% likelihood for adverse events, patients with cTnThs levels below the cutoff point had a low risk (negative predictive value, 83.5%). Increased cTnThs levels indicate adverse prognosis in patients with noncardiac causes of syncope, but not in patients with cardiac syncope being a risk factor for adverse outcome by itself. Patients with syncope presenting to the emergency department have a high proportion of life-threatening conditions. cTnThs levels show a limited diagnostic and predictive accuracy for the identification of patients with syncope at high risk. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Highly Sensitive Sensors Based on Metal-Oxide Nanocolumns for Fire Detection

    Directory of Open Access Journals (Sweden)

    Kwangjae Lee

    2017-02-01

    Full Text Available A fire detector is the most important component in a fire alarm system. Herein, we present the feasibility of a highly sensitive and rapid response gas sensor based on metal oxides as a high performance fire detector. The glancing angle deposition (GLAD technique is used to make the highly porous structure such as nanocolumns (NCs of various metal oxides for enhancing the gas-sensing performance. To measure the fire detection, the interface circuitry for our sensors (NiO, SnO2, WO3 and In2O3 NCs is designed. When all the sensors with various metal-oxide NCs are exposed to fire environment, they entirely react with the target gases emitted from Poly(vinyl chlorides (PVC decomposed at high temperature. Before the emission of smoke from the PVC (a hot-plate temperature of 200 °C, the resistances of the metal-oxide NCs are abruptly changed and SnO2 NCs show the highest response of 2.1. However, a commercial smoke detector did not inform any warning. Interestingly, although the NiO NCs are a p-type semiconductor, they show the highest response of 577.1 after the emission of smoke from the PVC (a hot-plate temperature of 350 °C. The response time of SnO2 NCs is much faster than that of a commercial smoke detector at the hot-plate temperature of 350 °C. In addition, we investigated the selectivity of our sensors by analyzing the responses of all sensors. Our results show the high potential of a gas sensor based on metal-oxide NCs for early fire detection.

  5. Measurement system for high-sensitivity LIBS analysis using ICCD camera in LabVIEW environment

    International Nuclear Information System (INIS)

    Zaytsev, S M; Popov, A M; Zorov, N B; Labutin, T A

    2014-01-01

    A measurement system based on ultrafast (up to 10 ns time resolution) intensified CCD detector ''Nanogate-2V'' (Nanoscan, Russia) was developed for high-sensitivity analysis by Laser-Induced Breakdown Spectrometry (LIBS). LabVIEW environment provided a high level of compatibility with variety of electronic instruments and an easy development of user interface, while Visual Studio environment was used for creation of LabVIEW compatible dll library with the use of ''Nanogate-2V'' SDK. The program for camera management and laser-induced plasma spectra registration was created with the use of Call Library Node in LabVIEW. An algorithm of integration of the second device ADC ''PCI-9812'' (ADLINK) to the measurement system was proposed and successfully implemented. This allowed simultaneous registration of emission and acoustic signals under laser ablation. The measured resolving power of spectrometer-ICCD system was equal to 12000 at 632 nm. An electron density of laser plasma was estimated with the use of H-α Balmer line. Steel spectra obtained at different delays were used for selection of the optimal conditions for manganese analytical signal registration. The feature of accumulation of spectra from several laser pulses was shown. The accumulation allowed reliable observation of silver signal at 328.07 nm in the LIBS spectra of soil (C Ag = 4.5 ppm). Finally, the correlation between acoustic and emission signals of plasma was found. Thus, technical possibilities of the developed LIBS system were demonstrated both for plasma diagnostics and analytical measurements

  6. Design Optimization of Structural Parameters for Highly Sensitive Photonic Crystal Label-Free Biosensors

    Directory of Open Access Journals (Sweden)

    Yun-ah Han

    2013-03-01

    Full Text Available The effects of structural design parameters on the performance of nano-replicated photonic crystal (PC label-free biosensors were examined by the analysis of simulated reflection spectra of PC structures. The grating pitch, duty, scaled grating height and scaled TiO2 layer thickness were selected as the design factors to optimize the PC structure. The peak wavelength value (PWV, full width at half maximum of the peak, figure of merit for the bulk and surface sensitivities, and surface/bulk sensitivity ratio were also selected as the responses to optimize the PC label-free biosensor performance. A parametric study showed that the grating pitch was the dominant factor for PWV, and that it had low interaction effects with other scaled design factors. Therefore, we can isolate the effect of grating pitch using scaled design factors. For the design of PC-label free biosensor, one should consider that: (1 the PWV can be measured by the reflection peak measurement instruments, (2 the grating pitch and duty can be manufactured using conventional lithography systems, and (3 the optimum design is less sensitive to the grating height and TiO2 layer thickness variations in the fabrication process. In this paper, we suggested a design guide for highly sensitive PC biosensor in which one select the grating pitch and duty based on the limitations of the lithography and measurement system, and conduct a multi objective optimization of the grating height and TiO2 layer thickness for maximizing performance and minimizing the influence of parameter variation. Through multi-objective optimization of a PC structure with a fixed grating height of 550 nm and a duty of 50%, we obtained a surface FOM of 66.18 RIU−1 and an S/B ratio of 34.8%, with a grating height of 117 nm and TiO2 height of 210 nm.

  7. Diagnosis of canine leptospirosis by a highly sensitive FRET-PCR targeting the lig genes.

    Directory of Open Access Journals (Sweden)

    Chuanling Xu

    Full Text Available Canine leptospirosis is underdiagnosed due to its wide spectrum of clinical presentations and the lack of a rapid and sensitive test for the accurate diagnosis of acute and chronic infections. In this study, we developed a highly sensitive and specific fluorescence resonance energy transfer (FRET-PCR to detect common pathogenic leptospires in dogs, including Leptospira interrogans serovars Autumnalis, Canicola, Copenhageni (Icterohaemorrhagiae serogroup and Pomona, and Leptospira kirschneri serovar Grippotyphosa. This PCR targets the lig genes, exclusively found in the pathogenic Leptospira species but not in saprophytic species (L. biflexa. A robust, high-stringency step-down real-time platform was coupled to the highly specific detection of leptospiral DNA by fluorescently labeled FRET probes. This enabled the detection of a single copy of the lig gene in a PCR containing DNA from up to 50 µL canine blood or 400 µL urine. Sensitivity determination by use of limiting serial dilutions of extracted leptospiral DNA indicated that the lig FRET-PCR we established was almost 100-fold more sensitive than the widely accepted lipL32 SYBR assay and 10-fold more sensitive than a 16S rRNA TaqMan assay. Application of this method to 207 dogs with potential leptospiral infection enabled us to diagnose three cases of canine leptospirosis characterized by low amounts of leptospiral DNA in body fluids. Detection of canine leptospirosis with the lig FRET-PCR was more sensitive with the lig FRET-PCR than with the 16S rRNA TaqMan PCR, which detected only 2 of the 3 cases, and the lipL32 SYBR PCR, which detected none of the 3 dogs with leptospirosis.

  8. Self-assembled dipeptide-gold nanoparticle hybrid spheres for highly sensitive amperometric hydrogen peroxide biosensors.

    Science.gov (United States)

    Gong, Yufei; Chen, Xu; Lu, Yanluo; Yang, Wensheng

    2015-04-15

    Novel self-assembled dipeptide-gold nanoparticle (DP-AuNP) hybrid microspheres with a hollow structure have been prepared in aqueous solution by a simple one-step method. Diphenylalanine (FF) dipeptide was used as a precursor to form simultaneously peptide spheres and a reducing agent to reduce gold ions to gold nanoparticles in water at 60°C. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that formed AuNPs were localized both inside and on the surface of the dipeptide spheres. Horseradish peroxidase (HRP) as a model enzyme was further immobilized on the dipeptide-AuNP hybrid spheres to construct a mediate H2O2 amperometric biosensor. UV-vis spectroscopy showed that the immobilized HRP retained its original structure. Cyclic voltammetry characterization demonstrated that the HRP/dipeptide-AuNP hybrid spheres modified glassy carbon electrode showed high electrocatalytic activity to H2O2. The proposed biosensor exhibited a wide linear response in the range from 5.0×10(-7) to 9.7×10(-4)M with a high sensitivity of 28.3µAmM(-1). A low detection limit of 1.0×10(-7)M was estimated at S/N=3. In addition, the biosensor possessed satisfactory reproducibility and long-term stability. These results indicated that the dipeptide-AuNP hybrid sphere is a promising matrix for application in the fabrication of electrochemical biosensors due to its excellent biocompatibility and good charge-transfer ability. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease

    Directory of Open Access Journals (Sweden)

    Tom Kai Ming Wang

    2018-02-01

    Full Text Available The conventional use of high-sensitivity troponins (hs-troponins is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic markers of left ventricular hypertrophy (LVH and structural heart disease (SHD. Patients undergoing computer gomography (CT coronary angiogram for low-intermediate risk chest pain and healthy volunteers were recruited. Hs-troponins Singulex I, Abbott I and Roche T and N-terminal pro-brain natriuretic peptide (NT-proBNP were evaluated in relation to SHD parameters including left ventricular hypertrophy (LVHEcho and left atrial enlargement (LAEEcho on echocardiography. 78 subjects who underwent echocardiography were included in this study. C-statistics (95% confidence interval of the four biomarkers for predicting LVHEcho were 0.84 (0.72–0.92, 0.84 (0.73–0.92, 0.75 (0.63–0.85 and 0.62 (0.49–0.74; for LAEEcho 0.74 (0.6–0.85, 0.78 (0.66–0.88, 0.55 (0.42–0.67 and 0.68 (0.62–0.85; and composite SHD 0.79 (0.66–0.88, 0.87 (0.75–0.94, 0.62 (0.49–0.73 and 0.74 (0.62–0.84 respectively. Optimal cut points for SHD were >1.2 ng/L, >1.6 ng/L, >8 ng/L and >18 pmol/L respectively. These results advocate the potential role of hs-troponins as screening tools for structural heart disease with theranostic implications.

  10. Stathmin is a highly sensitive and specific biomarker for vulvar high-grade squamous intraepithelial lesions.

    Science.gov (United States)

    Nooij, Linda S; Dreef, Enno J; Smit, Vincent T H B M; van Poelgeest, Mariëtte I E; Bosse, Tjalling

    2016-12-01

    Differentiating between human papilloma virus-dependent vulvar low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) remains difficult in selected cases. Stathmin, a protein involved in cell cycle progression, might be a useful additional marker for this differentiation. The aim of this study was to investigate the additional diagnostic value of stathmin expression in vulvar intraepithelial neoplastic (VIN) lesions. Immunohistochemical analysis was used to evaluate stathmin, P16 and Ki67 expression in 91 samples, including LSILs (n=16), HSILs (n=50), differentiated VIN (dVIN; n=10), lichen sclerosis (LS; n=10) and normal vulvar tissue (n=5). Stathmin was expressed in more than one-third of the epithelium in all HSILs and in 20% of LSILs. P16 and Ki67 were expressed in more than one-third of the epithelium in 94% of HSILs and in 13% and 40% of LSILs, respectively. Stathmin was expressed in more than one-third of the epithelium in 10% of the dVIN and in none of the LS or normal lesions. P16 and Ki67 expression was not present in more than one-third of the epithelium in any of these lesions. The sensitivity of stathmin for differentiating between LSILs and HSILs was 100% compared with a sensitivity of 94% for both p16 and Ki67. The specificity of stathmin, p16 and Ki67 was 80%, 87% and 60%, respectively. Stathmin is a highly sensitive and specific biomarker for the diagnosis of vulvar HSIL. In addition to the more commonly used immunohistochemical markers p16 and Ki67, stathmin can be a useful diagnostic tool for identifying HSILs, especially in cases in which differentiating between LSIL and HSIL is difficult. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  11. Uncooled EuSbTe3 photodetector highly sensitive from ultraviolet to terahertz frequencies

    Science.gov (United States)

    Niu, Ying Y.; Wu, Dong; Su, Yu Q.; Zhu, Hai; Wang, Biao; Wang, Ying X.; Zhao, Zi R.; Zheng, Ping; Niu, Jia S.; Zhou, Hui B.; Wei, Jian; Wang, Nan L.

    2018-01-01

    Light probe from Uv to THz is critical in photoelectronics and has great applications ranging from imaging, communication to medicine (Woodward et al 2002 Phys. Med. Biol. 47 3853-63 Pospischil et al 2013 Nat. Photon. 7 892-6 Martyniuk and Rogalski 2003 Prog. Quantum Electron. 27 59-210). However, the room temperature ultrabroadband photodetection across visible down to far-infrared is still challenging. The challenging arises mainly from the lack of suitable photoactive materials. Because that conventional semiconductors, such as silicon, have their photosensitive properties cut off by the bandgap and are transparent to spectrum at long-wavelength infrared side (Ciupa and Rogalski 1997 Opto-Electron. Rev. 5 257-66 Tonouchi 2007 Nat. Photon. 1 97-105 Sizov and Rogalski 2010 Prog. Quantum Electron. 34 278-347 Kinch 2000 J. Electron. Mater. 29 809-17). Comparatively, the dielectrics with very narrow band-gap but maintain the semiconductor-like electrical conduction would have priorities for ultrabroadband photodetection. Here we report on EuSbTe3 is highly sensitive from ultraviolet directly to terahertz (THz) at room temperature. High photoresponsivities 1-8 A W-1 reached in our prototype EuSbTe3 detectors with low noise equivalent power (NEP) recorded, for instances ~150 pW · Hz-1/2 (at λ  =  532 nm) and ~0.6 nW · Hz-1/2 (at λ  =  118.8 µm) respectively. Our results demonstrate a promising system with direct photosensitivity extending well into THz regime at room temperature, shed new light on exploring more sophisticated multi-band photoelectronics.

  12. A highly sensitive and flexible magnetic nanoprobe labeled immunochromatographic assay platform for pathogen Vibrio parahaemolyticus.

    Science.gov (United States)

    Liu, Yingying; Zhang, Zhaohuan; Wang, Yilong; Zhao, Yong; Lu, Ying; Xu, Xiaowei; Yan, Jun; Pan, Yingjie

    2015-10-15

    A magnetic nanoprobe labeled immunochromatographic test strip (MNP/ICTS) was developed to detect food-borne pathogen Vibrio parahaemolyticus. Specific antibody against V. parahaemolyticus was used as test line by coating onto the nitrocellulose membrane. Magnetic nanoprobe was prepared by immobilizing the specific antibody onto the surface of superparamagnetic nanoparticles. Specificity and sensitivity of the MNP/ICTS system were verified by artificially contaminated shrimp homogenate samples. Reliability and application feasibility of the MNP/ICTS system were demonstrated by using seafood samples (n=36). Comparing with polymerase chain reaction (PCR) and traditional culture methods, the MNP/ICTS system is found to be not only a rapid qualitative analysis (~10 min), but also an accurately quantitative detection platform. Through its rapid magnetic separation property, the MNP/ICTS system is capable to flexibly combine with a sample enrichment and pre-incubation process. This combination makes the qualitative sensitivity for the food samples surged more than 100-fold. A naked-eye observation of 1.58×10(2) CFU/g V. parahaemolyticus was realized. This sensitivity could meet the V. parahaemolyticus test threshold value in many countries. Also, the total sample pre-treatment plus MNP/ICTS assay only needs about 4.5h. Namely, we can get test results in a day. Hence, the developed MNP/ICTS assay platform is simple, rapid and highly sensitive. It is a flexible test platform for pathogen detection. The favorable comparison with PCR and culture methods further proves that the developed MNP/ICTS is applicable into food-borne pathogen or other areas where a simple, rapid, sensitive and point-of-care analysis is desirable. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. An Improved High-Sensitivity Airborne Transient Electromagnetic Sensor for Deep Penetration

    Science.gov (United States)

    Chen, Shudong; Guo, Shuxu; Wang, Haofeng; He, Miao; Liu, Xiaoyan; Qiu, Yu; Zhang, Shuang; Yuan, Zhiwen; Zhang, Haiyang; Fang, Dong; Zhu, Jun

    2017-01-01

    The investigation depth of transient electromagnetic sensors can be effectively increased by reducing the system noise, which is mainly composed of sensor internal noise, electromagnetic interference (EMI), and environmental noise, etc. A high-sensitivity airborne transient electromagnetic (AEM) sensor with low sensor internal noise and good shielding effectiveness is of great importance for deep penetration. In this article, the design and optimization of such an AEM sensor is described in detail. To reduce sensor internal noise, a noise model with both a damping resistor and a preamplifier is established and analyzed. The results indicate that a sensor with a large diameter, low resonant frequency, and low sampling rate will have lower sensor internal noise. To improve the electromagnetic compatibility of the sensor, an electromagnetic shielding model for a central-tapped coil is established and discussed in detail. Previous studies have shown that unclosed shields with multiple layers and center grounding can effectively suppress EMI and eddy currents. According to these studies, an improved differential AEM sensor is constructed with a diameter, resultant effective area, resonant frequency, and normalized equivalent input noise of 1.1 m, 114 m2, 35.6 kHz, and 13.3 nV/m2, respectively. The accuracy of the noise model and the shielding effectiveness of the sensor have been verified experimentally. The results show a good agreement between calculated and measured results for the sensor internal noise. Additionally, over 20 dB shielding effectiveness is achieved in a complex electromagnetic environment. All of these results show a great improvement in sensor internal noise and shielding effectiveness. PMID:28106718

  14. High sensitivity tracer imaging of iron oxides using magnetic particle imaging

    Energy Technology Data Exchange (ETDEWEB)

    Goodwill, Patrick [University of California, Dept. of Bioengineering, Berkeley, CA (United States); Konkle, Justin; Lu, Kuan; Zheng, Bo [UC Berkeley (UCSF), Joint Graduate Group in Bioengineering, CA (United States); Conolly, Steven [University of California, Berkeley Bioengineering, Electrical Engineering, and Computer Science, CA (United States)

    2014-07-01

    Full text: Magnetic Particle Imaging (MPI) is a new tracer imaging modality that is gaining significant interest from NMR and MRI researchers. While the physics of MPI differ substantially from MRI, it employs hardware and imaging concepts that are familiar to MRI researchers, such as magnetic excitation and detection, pulse sequences, and relaxation effects. Furthermore, MPI employs the same superparamagnetic iron oxide (SPIO) contrast agents that are sometimes used for MR angiography and are often used for MRI cell tracking studies. These SPIOs are much safer for humans than iodine or gadolinium, especially for Chronic Kidney Disease (CKD) patients. The weak kidneys of CKD patients cannot safely excrete iodine or gadolinium, leading to increased morbidity and mortality after iodinated X-ray or CT angiograms, or after gadolinium-MRA studies. Iron oxides, on the other hand, are processed in the liver, and have been shown to be safe even for CKD patients. Unlike the 'black blood' contrast generated by SPIOs in MRI due to increased T2 dephasing, SPIOs in MPI generate positive, 'bright blood' contrast. With this ideal contrast, even prototype MPI scanners can already achieve fast, high-sensitivity, and high-contrast angiograms with millimeter-scale resolutions in phantoms and in animals. Moreover, MPI shows great potential for an exciting array of applications, including stem cell tracking in vivo, first-pass contrast studies to diagnose or stage cancer, and inflammation imaging in vivo. So far, only a handful of prototype small-animal MPI scanners have been constructed worldwide. Hence, MPI is open to great advances, especially in hardware, pulse sequence, and nanoparticle improvements, with the potential to revolutionize the biomedical imaging field. (author)

  15. A combined HM-PCR/SNuPE method for high sensitive detection of rare DNA methylation

    Directory of Open Access Journals (Sweden)

    Tierling Sascha

    2010-06-01

    Full Text Available Abstract Background DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or complex tissue samples is crucial for the understanding of tumor etiology, clinical diagnosis and treatment. In this paper, we describe a combined method to monitor the presence of methylated tumor DNA in an excess of unmethylated background DNA of non-tumorous cells. The method combines heavy methyl-PCR, which favors preferential amplification of methylated marker sequence from bisulfite-treated DNA with a methylation-specific single nucleotide primer extension monitored by ion-pair, reversed-phase, high-performance liquid chromatography separation. Results This combined method allows detection of 14 pg (that is, four to five genomic copies of methylated chromosomal DNA in a 2000-fold excess (that is, 50 ng of unmethylated chromosomal background, with an analytical sensitivity of > 90%. We outline a detailed protocol for the combined assay on two examples of known cancer markers (SEPT9 and TMEFF2 and discuss general aspects of assay design and data interpretation. Finally, we provide an application example for rapid testing on tumor methylation in plasma DNA derived from a small cohort of patients with colorectal cancer. Conclusion The method allows unambiguous detection of rare DNA methylation, for example in body fluid or DNA isolates from cells or tissues, with very high sensitivity and accuracy. The application combines standard technologies and can easily be adapted to any target region of interest. It does not require costly reagents and can be used for routine screening of many samples.

  16. Highly sensitive and specific derivatization strategy to profile and quantitate eicosanoids by UPLC-MS/MS

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Ting; Tie, Cai; Wang, Zhe; Zhang, Jin-Lan, E-mail: zhjl@imm.ac.cn

    2017-01-15

    Eicosanoids are signaling molecules mainly oxidized from arachidonic acid (ARA) and eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). They have attracted increasing attention from the scientists attributing to their essential physiological functions. However, their quantification have long been challenged by the low abundance, high structure similarity, poor stability and limited ionization efficiency. In this paper, an ultra-high performance liquid chromatograph coupled with tandem mass spectrometry (UPLC-MS/MS) strategy was developed for the comprehensive profiling of more than 60 eicosanoids based on an efficient derivatization reagent 2,4-bis(diethylamino)-6-hydrazino-1,3,5-triazine (T3) and general multiple reaction monitoring (MRM) parameters. Carboxylic acid of eicosanoid was converted to amide in 30 min at 4 °C with derivatization yield larger than 99%. Limits of quantitation (LOQs) for derivatized eicosanoids varied from 0.05 to 50 pg depending on their structures. The sensitivities of derivatized eicosanoids were enhanced by 10- to 5000-folds compared to free eicosanoids. Stabilities of T3 modified eicosanoids were also highly improved compared to free eicosanoids. This new method can also be used to quantify eicosanoids in bio-samples using isotopic internal standards with high efficiency and reliability within 19 min. 46 and 50 eicosanoids in rat plasma and heart tissue from control and acute myocardial ischemia (AMI) model rats were respectively profiled and quantitated using this new method. And 24 of 46 and 25 of 50 eicosanoids were found to be significantly changed between control and model groups. The changed eicosanoids related to AMI modeling were further statistically analyzed and interpreted based on eicosanoid metabolism pathway. - Highlights: • Eicosanoids are important signaling molecules. • A highly sensitive and specific derivatization strategy was developed for eicosanoid profiling. • The strategy was employed for

  17. Serial High-Sensitivity Troponin T in Post-Primary Angioplasty Exercise Test

    Energy Technology Data Exchange (ETDEWEB)

    Vaz, Humberto Andres, E-mail: humbertovaz@cardiol.br; Vanz, Ana Paula; Castro, Iran [Instituto de Cardiologia - Fundação Universitária de Cardiologia, Porto Alegre, RS (Brazil)

    2016-04-15

    The kinetics of high-sensitivity troponin T (hscTnT) release should be studied in different situations, including functional tests with transient ischemic abnormalities. To evaluate the release of hscTnT by serial measurements after exercise testing (ET), and to correlate hscTnT elevations with abnormalities suggestive of ischemia. Patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary angioplasty were referred for ET 3 months after infarction. Blood samples were collected to measure basal hscTnT immediately before (TnT{sub 0h}), 2 (TnT{sub 2h}), 5 (TnT{sub 5h}), and 8 hours (TnT{sub 8h}) after ET. The outcomes were peak hscTnT, TnT{sub 5h}/TnT{sub 0h} ratio, and the area under the blood concentration-time curve (AUC) for hscTnT levels. Log-transformation was performed on hscTnT values, and comparisons were assessed with the geometric mean ratio, along with their 95% confidence intervals. Statistical significance was assessed by analysis of covariance with no adjustment, and then, adjusted for TnT{sub 0h}, age and sex, followed by additional variables (metabolic equivalents, maximum heart rate achieved, anterior wall STEMI, and creatinine clearance). This study included 95 patients. The highest geometric means were observed at 5 hours (TnT{sub 5h}). After adjustments, peak hscTnT, TnT{sub 5h}/TnT{sub 0h} and AUC were 59% (p = 0.002), 59% (p = 0.003) and 45% (p = 0.003) higher, respectively, in patients with an abnormal ET as compared to those with normal tests. Higher elevations of hscTnT may occur after an abnormal ET as compared to a normal ET in patients with STEMI.

  18. High sensitive mesoporous TiO2-coated love wave device for heavy metal detection.

    Science.gov (United States)

    Gammoudi, I; Blanc, L; Moroté, F; Grauby-Heywang, C; Boissière, C; Kalfat, R; Rebière, D; Cohen-Bouhacina, T; Dejous, C

    2014-07-15

    This work deals with the design of a highly sensitive whole cell-based biosensor for heavy metal detection in liquid medium. The biosensor is constituted of a Love wave sensor coated with a polyelectrolyte multilayer (PEM). Escherichia coli bacteria are used as bioreceptors as their viscoelastic properties are influenced by toxic heavy metals. The acoustic sensor is constituted of a quartz substrate with interdigitated transducers and a SiO2 guiding layer. However, SiO2 shows some degradation when used in a saline medium. Mesoporous TiO2 presents good mechanical and chemical stability and offers a high active surface area. Then, the addition of a thin titania layer dip-coated onto the acoustic path of the sensor is proposed to overcome the silica degradation and to improve the mass effect sensitivity of the acoustic device. PEM and bacteria deposition, and heavy metal influence, are real time monitored through the resonance frequency variations of the acoustic device. The first polyelectrolyte layer is inserted through the titania mesoporosity, favouring rigid link of the PEM on the sensor and improving the device sensitivity. Also, the mesoporosity of surface increases the specific surface area which can be occupied and favors the formation of homogeneous PEM. It was found a frequency shift near -20±1 kHz for bacteria immobilization with titania film instead of -7±3 kHz with bare silica surface. The sensitivity is highlighted towards cadmium detection. Moreover, in this paper, particular attention is given to the immobilization of bacteria and to biosensor lifetime. Atomic Force Microscopy characterizations of the biosurface have been done for several weeks. They showed significant morphological differences depending on the bacterial life time. We noticed that the lifetime of the biosensor is longer in the case of using a mesoporous TiO2 layer. Copyright © 2013 Elsevier B.V. All rights reserved.

  19. Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease.

    Science.gov (United States)

    Wang, Tom Kai Ming; Dugo, Clementina; Gillian, Yvonne; Yvonne, Wynne; Heather, Semple; Kevin, Smith; Peter, Cleave; Jonathan, Christiansen; Andrew, To; Nezar, Amir; Scott, Tony; Ross, Boswell; Patrick, Gladding

    2018-02-15

    The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic markers of left ventricular hypertrophy (LVH) and structural heart disease (SHD). Patients undergoing computer gomography (CT) coronary angiogram for low-intermediate risk chest pain and healthy volunteers were recruited. Hs-troponins Singulex I, Abbott I and Roche T and N-terminal pro-brain natriuretic peptide (NT-proBNP) were evaluated in relation to SHD parameters including left ventricular hypertrophy (LVH Echo ) and left atrial enlargement (LAE Echo ) on echocardiography. 78 subjects who underwent echocardiography were included in this study. C-statistics (95% confidence interval) of the four biomarkers for predicting LVH Echo were 0.84 (0.72-0.92), 0.84 (0.73-0.92), 0.75 (0.63-0.85) and 0.62 (0.49-0.74); for LAE Echo 0.74 (0.6-0.85), 0.78 (0.66-0.88), 0.55 (0.42-0.67) and 0.68 (0.62-0.85); and composite SHD 0.79 (0.66-0.88), 0.87 (0.75-0.94), 0.62 (0.49-0.73) and 0.74 (0.62-0.84) respectively. Optimal cut points for SHD were >1.2 ng/L, >1.6 ng/L, >8 ng/L and >18 pmol/L respectively. These results advocate the potential role of hs-troponins as screening tools for structural heart disease with theranostic implications.

  20. A luminescent Lanthanide-free MOF nanohybrid for highly sensitive ratiometric temperature sensing in physiological range.

    Science.gov (United States)

    Zhou, You; Zhang, Denan; Zeng, Jin; Gan, Ning; Cuan, Jing

    2018-05-01

    Luminescent MOF materials with tunable emissions and energy/charge transfer processes have been extensively explored as ratiometric temperature sensors. However, most of the ratiometric MOF thermometers reported thus far are based on the MOFs containing photoactive lanthanides, which are potentially facing cost issue and serious supply shortage. Here, we present a ratiometric luminescent thermometer based on a dual-emitting lanthanide-free MOF hybrid, which is developed by encapsulation of a fluorescent dye into a robust nanocrystalline zirconium-based MOF through a one-pot synthesis approach. The structure and morphology of the hybrid product was characterized by Powder X-ray diffraction (PXRD), N 2 adsorption-desorption measurement and Scanning electron microscopy (SEM). The pore confinement effect well isolates the guest dye molecules and therefore suppresses the nonradiative energy transfer process between dye molecules. The incorporated dye emission is mainly sensitized by the organic linkers within MOF through fluorescence resonance energy transfer. The ratiometric luminescence of the MOF hybrid shows a significant response to temperature due to the thermal-related back energy transfer process from dye molecules and organic linkers, thus can be exploited for self-calibrated temperature sensing. The maximum thermometric sensitivity is 1.19% °C -1 in the physiological temperature range, which is among the highest for the ratiomtric MOF thermometers that operating in 25-45°C. The temperature resolution is better than 0.1°C over the entire operative range (20-60°C). By integrating the advantages of excellent stability, nanoscale nature, and high sensitivity and precision in the physiological temperature range, this dye@MOF hybrid might have potential application in biomedical diagnosis. What' more, this work has expanded the possibility of non-lanthanide luminescent MOF materials for the development of ratiometric temperature sensors. Copyright © 2018

  1. Highly Sensitive Sensors Based on Metal-Oxide Nanocolumns for Fire Detection.

    Science.gov (United States)

    Lee, Kwangjae; Shim, Young-Seok; Song, Young Geun; Han, Soo Deok; Lee, Youn-Sung; Kang, Chong-Yun

    2017-02-07

    A fire detector is the most important component in a fire alarm system. Herein, we present the feasibility of a highly sensitive and rapid response gas sensor based on metal oxides as a high performance fire detector. The glancing angle deposition (GLAD) technique is used to make the highly porous structure such as nanocolumns (NCs) of various metal oxides for enhancing the gas-sensing performance. To measure the fire detection, the interface circuitry for our sensors (NiO, SnO₂, WO₃ and In₂O₃ NCs) is designed. When all the sensors with various metal-oxide NCs are exposed to fire environment, they entirely react with the target gases emitted from Poly(vinyl chlorides) (PVC) decomposed at high temperature. Before the emission of smoke from the PVC (a hot-plate temperature of 200 °C), the resistances of the metal-oxide NCs are abruptly changed and SnO₂ NCs show the highest response of 2.1. However, a commercial smoke detector did not inform any warning. Interestingly, although the NiO NCs are a p -type semiconductor, they show the highest response of 577.1 after the emission of smoke from the PVC (a hot-plate temperature of 350 °C). The response time of SnO₂ NCs is much faster than that of a commercial smoke detector at the hot-plate temperature of 350 °C. In addition, we investigated the selectivity of our sensors by analyzing the responses of all sensors. Our results show the high potential of a gas sensor based on metal-oxide NCs for early fire detection.

  2. Nanoprobe-Initiated Enzymatic Polymerization for Highly Sensitive Electrochemical DNA Detection.

    Science.gov (United States)

    Wan, Ying; Wang, Pengjuan; Su, Yan; Wang, Lihua; Pan, Dun; Aldalbahi, Ali; Yang, Shulin; Zuo, Xiaolei

    2015-11-25

    Electrochemical DNA (E-DNA) sensors have been greatly developed and play an important role in early diagnosis of different diseases. To determine the extremely low abundance of DNA biomarkers in clinical samples, scientists are making unremitting efforts toward achieving highly sensitive and selective E-DNA sensors. Here, a novel E-DNA sensor was developed taking advantage of the signal amplification efficiency of nanoprobe-initiated enzymatic polymerization (NIEP). In the NIEP based E-DNA sensor, the capture probe DNA was thiolated at its 3'-terminal to be immobilized onto gold electrode, and the nanoprobe was fabricated by 5'-thiol-terminated signal probe DNA conjugated gold nanoparticles (AuNPs). Both of the probes could simultaneously hybridize with the target DNA to form a "sandwich" structure followed by the terminal deoxynucleotidyl transferase (TdT)-catalyzed elongation of the free 3'-terminal of DNA on the nanoprobe. During the DNA elongation, biotin labels were incorporated into the NIEP-generated long single-stranded DNA (ssDNA) tentacles, leading to specific binding of avidin modified horseradish peroxidase (Av-HRP). Since there are hundreds of DNA probes on the nanoprobe, one hybridization event would generate hundreds of long ssDNA tentacles, resulting in tens of thousands of HRP catalyzed reduction of hydrogen peroxide and sharply increasing electrochemical signals. By employing nanoprobe and TdT, it is demonstrated that the NIEP amplified E-DNA sensor has a detection limit of 10 fM and excellent differentiation ability for even single-base mismatch.

  3. High-sensitivity multifunctional spinner magnetometer using a magneto-impedance sensor

    Science.gov (United States)

    Kodama, Kazuto

    2017-01-01

    A novel spinner magnetometer was developed with a wide dynamic range from 10-10 to 10-4 Am2 and a resolution of 10-11 Am2. High sensitivity was achieved with the use of a magneto-impedance (MI) sensor, which is a compact, sensitive magnetic sensor used industrially. Its slow-spinning rate (5 Hz) and the incorporation of a unique mechanism for adjusting the spacing between the sensing unit and the spinning axis allows the measurement of fragile samples sized 10-50 mm. The sensor configuration, in which a pair of MI sensors is connected in opposite serial, along with an amplification circuit with a programmable low-pass filter, reduces the problems of external noise and sensor drift. The signal, with reference to the spinning frequency, is detected with a lock-in amplifier. The MI spinner has two selectable measurement modes: the fundamental mode (F mode) and the harmonic mode (H mode). Measurements in the F mode detect signals of the fundamental frequency (5 Hz), in the same way as conventional spinner magnetometers. In the H mode, the second (10 Hz) and the third (15 Hz) harmonic components are measured, in addition to the fundamental component. Tests in the H mode were performed using a small coil and a natural sample to simulate dipoles with various degrees of offset. The results revealed that the magnitude of the fundamental component of the offset dipole was systematically larger (by several percent) than that of the nonoffset dipole. These findings suggest that this novel MI spinner will be useful in estimating the inhomogeneity of the magnetization of a sample that can equivalently be described by an offset dipole.

  4. High sensitivity tracer imaging of iron oxides using magnetic particle imaging

    International Nuclear Information System (INIS)

    Goodwill, Patrick; Konkle, Justin; Lu, Kuan; Zheng, Bo; Conolly, Steven

    2014-01-01

    Full text: Magnetic Particle Imaging (MPI) is a new tracer imaging modality that is gaining significant interest from NMR and MRI researchers. While the physics of MPI differ substantially from MRI, it employs hardware and imaging concepts that are familiar to MRI researchers, such as magnetic excitation and detection, pulse sequences, and relaxation effects. Furthermore, MPI employs the same superparamagnetic iron oxide (SPIO) contrast agents that are sometimes used for MR angiography and are often used for MRI cell tracking studies. These SPIOs are much safer for humans than iodine or gadolinium, especially for Chronic Kidney Disease (CKD) patients. The weak kidneys of CKD patients cannot safely excrete iodine or gadolinium, leading to increased morbidity and mortality after iodinated X-ray or CT angiograms, or after gadolinium-MRA studies. Iron oxides, on the other hand, are processed in the liver, and have been shown to be safe even for CKD patients. Unlike the 'black blood' contrast generated by SPIOs in MRI due to increased T2 dephasing, SPIOs in MPI generate positive, 'bright blood' contrast. With this ideal contrast, even prototype MPI scanners can already achieve fast, high-sensitivity, and high-contrast angiograms with millimeter-scale resolutions in phantoms and in animals. Moreover, MPI shows great potential for an exciting array of applications, including stem cell tracking in vivo, first-pass contrast studies to diagnose or stage cancer, and inflammation imaging in vivo. So far, only a handful of prototype small-animal MPI scanners have been constructed worldwide. Hence, MPI is open to great advances, especially in hardware, pulse sequence, and nanoparticle improvements, with the potential to revolutionize the biomedical imaging field. (author)

  5. Serial High-Sensitivity Troponin T in Post-Primary Angioplasty Exercise Test

    Directory of Open Access Journals (Sweden)

    Humberto Andres Vaz

    2016-04-01

    Full Text Available Abstract Background: The kinetics of high-sensitivity troponin T (hscTnT release should be studied in different situations, including functional tests with transient ischemic abnormalities. Objective: To evaluate the release of hscTnT by serial measurements after exercise testing (ET, and to correlate hscTnT elevations with abnormalities suggestive of ischemia. Methods: Patients with acute ST-segment elevation myocardial infarction (STEMI undergoing primary angioplasty were referred for ET 3 months after infarction. Blood samples were collected to measure basal hscTnT immediately before (TnT0h, 2 (TnT2h, 5 (TnT5h, and 8 hours (TnT8h after ET. The outcomes were peak hscTnT, TnT5h/TnT0h ratio, and the area under the blood concentration-time curve (AUC for hscTnT levels. Log-transformation was performed on hscTnT values, and comparisons were assessed with the geometric mean ratio, along with their 95% confidence intervals. Statistical significance was assessed by analysis of covariance with no adjustment, and then, adjusted for TnT0h, age and sex, followed by additional variables (metabolic equivalents, maximum heart rate achieved, anterior wall STEMI, and creatinine clearance. Results: This study included 95 patients. The highest geometric means were observed at 5 hours (TnT5h. After adjustments, peak hscTnT, TnT5h/TnT0h and AUC were 59% (p = 0.002, 59% (p = 0.003 and 45% (p = 0.003 higher, respectively, in patients with an abnormal ET as compared to those with normal tests. Conclusion: Higher elevations of hscTnT may occur after an abnormal ET as compared to a normal ET in patients with STEMI.

  6. An Improved High-Sensitivity Airborne Transient Electromagnetic Sensor for Deep Penetration

    Directory of Open Access Journals (Sweden)

    Shudong Chen

    2017-01-01

    Full Text Available The investigation depth of transient electromagnetic sensors can be effectively increased by reducing the system noise, which is mainly composed of sensor internal noise, electromagnetic interference (EMI, and environmental noise, etc. A high-sensitivity airborne transient electromagnetic (AEM sensor with low sensor internal noise and good shielding effectiveness is of great importance for deep penetration. In this article, the design and optimization of such an AEM sensor is described in detail. To reduce sensor internal noise, a noise model with both a damping resistor and a preamplifier is established and analyzed. The results indicate that a sensor with a large diameter, low resonant frequency, and low sampling rate will have lower sensor internal noise. To improve the electromagnetic compatibility of the sensor, an electromagnetic shielding model for a central-tapped coil is established and discussed in detail. Previous studies have shown that unclosed shields with multiple layers and center grounding can effectively suppress EMI and eddy currents. According to these studies, an improved differential AEM sensor is constructed with a diameter, resultant effective area, resonant frequency, and normalized equivalent input noise of 1.1 m, 114 m2, 35.6 kHz, and 13.3 nV/m2, respectively. The accuracy of the noise model and the shielding effectiveness of the sensor have been verified experimentally. The results show a good agreement between calculated and measured results for the sensor internal noise. Additionally, over 20 dB shielding effectiveness is achieved in a complex electromagnetic environment. All of these results show a great improvement in sensor internal noise and shielding effectiveness.

  7. Advanced Image Processing of Aerial Imagery

    Science.gov (United States)

    Woodell, Glenn; Jobson, Daniel J.; Rahman, Zia-ur; Hines, Glenn

    2006-01-01

    Aerial imagery of the Earth is an invaluable tool for the assessment of ground features, especially during times of disaster. Researchers at the NASA Langley Research Center have developed techniques which have proven to be useful for such imagery. Aerial imagery from various sources, including Langley's Boeing 757 Aries aircraft, has been studied extensively. This paper discusses these studies and demonstrates that better-than-observer imagery can be obtained even when visibility is severely compromised. A real-time, multi-spectral experimental system will be described and numerous examples will be shown.

  8. Aerial pruning mechanism, initial real environment test.

    Science.gov (United States)

    Molina, Javier; Hirai, Shinichi

    2017-01-01

    In this research, a pruning mechanism for aerial pruning tasks is tested in a real environment. Since the final goal of the aerial pruning robot will be to prune tree branches close to power lines, some experiments related to wireless communication and pruning performance were conducted. The experiments consisted of testing the communication between two XBee RF modules for monitoring purposes as well as testing the speed control of the circular saw used for pruning tree branches. Results show that both the monitoring and the pruning tasks were successfully done in a real environment.

  9. ARM Unmanned Aerial Systems Implementation Plan

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, Beat [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ivey, Mark [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-11-01

    Recent advances in Unmanned Aerial Systems (UAS) coupled with changes in the regulatory environment for operations of UAS in the National Airspace increase the potential value of UAS to the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility. UAS include unmanned aerial vehicles (UAV) and tethered balloon systems (TBS). The roles UAVs and TBSs could play within the ARM Facility, particularly science questions they could help address, have been discussed in several workshops, reports, and vision documents, including: This document describes the implementation of a robust and vigorous program for use of UAV and TBS for the science missions ARM supports.

  10. High mass resolution time of flight mass spectrometer for measuring products in heterogeneous catalysis in highly sensitive microreactors

    DEFF Research Database (Denmark)

    Andersen, Thomas; Jensen, Robert; Christensen, M. K.

    2012-01-01

    We demonstrate a combined microreactor and time of flight system for testing and characterization of heterogeneous catalysts with high resolution mass spectrometry and high sensitivity. Catalyst testing is performed in silicon-based microreactors which have high sensitivity and fast thermal...... response. Gas analysis is performed with a time of flight mass spectrometer with a modified nude Bayard-Alpert ionization gauge as gas ionization source. The mass resolution of the time of flight mass spectrometer using the ion gauge as ionization source is estimated to m∕Δm > 2500. The system design...... is superior to conventional batch and flow reactors with accompanying product detection by quadrupole mass spectrometry or gas chromatography not only due to the high sensitivity, fast temperature response, high mass resolution, and fast acquisition time of mass spectra but it also allows wide mass range (0...

  11. "Food company sponsors are kind, generous and cool": (mis)conceptions of junior sports players.

    Science.gov (United States)

    Kelly, Bridget; Baur, Louise A; Bauman, Adrian E; King, Lesley; Chapman, Kathy; Smith, Ben J

    2011-09-05

    Children's exposure to unhealthy food marketing influences their food knowledge, preferences and consumption. Sport sponsorship by food companies is widespread and industry investment in this marketing is increasing. This study aimed to assess children's awareness of sport sponsors and their brand-related attitudes and purchasing intentions in response to this marketing. Sports clubs known to have food sponsors and representing the most popular sports for Australian children across a range of demographic areas were recruited. Interview-based questionnaires were conducted at clubs with children aged 10-14 years (n = 103) to examine their recall of local sports club and elite sport sponsors, and their attitudes towards sponsors and sponsorship activities. Most children (68%) could recall sponsors of their sports club, naming a median of two sponsors, including a median of one food company sponsor each. Almost half (47%) of children could recall any sponsors of their favourite elite sporting team. Children aged 10-11 years were more likely than older children to report that they thought about sponsors when buying something to eat or drink (P sport performance (86% and 76%, respectively). Around one-third of children reported liking the company more after receiving these rewards. Children's high recall of food and beverage company sport sponsors and their positive attitudes towards these sponsors and their promotions is concerning as this is likely to be linked to children's food preferences and consumption. Limiting children's exposure to this marketing is an important initiative to improve children's nutrition.

  12. "Food company sponsors are kind, generous and cool": (Misconceptions of junior sports players

    Directory of Open Access Journals (Sweden)

    King Lesley

    2011-09-01

    Full Text Available Abstract Background Children's exposure to unhealthy food marketing influences their food knowledge, preferences and consumption. Sport sponsorship by food companies is widespread and industry investment in this marketing is increasing. This study aimed to assess children's awareness of sport sponsors and their brand-related attitudes and purchasing intentions in response to this marketing. Methods Sports clubs known to have food sponsors and representing the most popular sports for Australian children across a range of demographic areas were recruited. Interview-based questionnaires were conducted at clubs with children aged 10-14 years (n = 103 to examine their recall of local sports club and elite sport sponsors, and their attitudes towards sponsors and sponsorship activities. Results Most children (68% could recall sponsors of their sports club, naming a median of two sponsors, including a median of one food company sponsor each. Almost half (47% of children could recall any sponsors of their favourite elite sporting team. Children aged 10-11 years were more likely than older children to report that they thought about sponsors when buying something to eat or drink (P Conclusions Children's high recall of food and beverage company sport sponsors and their positive attitudes towards these sponsors and their promotions is concerning as this is likely to be linked to children's food preferences and consumption. Limiting children's exposure to this marketing is an important initiative to improve children's nutrition.

  13. 1935 15' Quad #081 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  14. 1935 15' Quad #176 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  15. 1935 15' Quad #410 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  16. 1935 15' Quad #150 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  17. 1935 15' Quad #151 Aerial Photo Mosaic Index - NM

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  18. 1935 15' Quad #171 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  19. 1935 15' Quad #268 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  20. 1935 15' Quad #100 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  1. 1935 15' Quad #004 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  2. 1935 15' Quad #054 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  3. 1935 15' Quad #125 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  4. 1935 15' Quad #371 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  5. 1935 15' Quad #025 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  6. 1935 15' Quad #086 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  7. 1935 15' Quad #196 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  8. 1935 15' Quad #243 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  9. 1935 15' Quad #155 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  10. 1935 15' Quad #361 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  11. 1935 15' Quad #368 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  12. 1935 15' Quad #177 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  13. 1935 15' Quad #387 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  14. 1935 15' Quad #060 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  15. 1935 15' Quad #270 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  16. 1935 15' Quad #180 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  17. 1935 15' Quad #349 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  18. 1935 15' Quad #152 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  19. 1935 15' Quad #049 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  20. 1935 15' Quad #315 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  1. 1935 15' Quad #316 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  2. 1935 15' Quad #293 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  3. 1935 15' Quad #319 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  4. 1935 15' Quad #364 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  5. 1935 15' Quad #122 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  6. 1935 15' Quad #195 Aerial Photo Mosaic Index - AZ

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  7. 1935 15' Quad #033 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  8. 1935 15' Quad #170 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  9. 1935 15' Quad #124 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  10. 1935 15' Quad #195 Aerial Photo Mosaic Index - NM

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  11. Index for SCS 1934-1937 Aerial Photography

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial photographs are retrievable on a frame by frame basis. The aerial photo inventory contains imagery from various sources that are now archived at the Earth...

  12. 1935 15' Quad #457 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  13. 1935 15' Quad #370 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  14. 1935 15' Quad #197 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  15. 1935 15' Quad #442 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  16. 1935 15' Quad #393 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  17. 1935 15' Quad #365 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  18. 1935 15' Quad #148 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  19. 1935 15' Quad #098 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  20. 1935 15' Quad #078 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  1. 1935 15' Quad #417 Aerial Photo Mosaic Index - AZ

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  2. 1935 15' Quad #250 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  3. 1935 15' Quad #055 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  4. 1935 15' Quad #109 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  5. 1935 15' Quad #099 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  6. 1935 15' Quad #291 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  7. 1935 15' Quad #131 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  8. 1935 15' Quad #008 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  9. 1935 15' Quad #391 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  10. 1935 15' Quad #314 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  11. 1935 15' Quad #179 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  12. 1935 15' Quad #075 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  13. 1935 15' Quad #076 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  14. 1935 15' Quad #248 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  15. 1935 15' Quad #374 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  16. 1935 15' Quad #273 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  17. 1935 15' Quad #265 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  18. 1935 15' Quad #271 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  19. 1935 15' Quad #080 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  20. 1935 15' Quad #153 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  1. 1935 15' Quad #038 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  2. 1935 15' Quad #128 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  3. 1949-50 DIO USFS Aerial Photo Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial photographs are retrievable on a frame by frame basis. The aerial photo inventory contains imagery from various sources that are now archived at the Earth...

  4. 1935 15' Quad #172 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  5. 1935 15' Quad #242 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  6. 1935 15' Quad #223 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  7. 1935 15' Quad #174 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  8. 1935 15' Quad #363 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  9. 1935 15' Quad #375 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  10. 1935 15' Quad #222 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  11. 1935 15' Quad #386 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  12. 1935 15' Quad #267 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  13. 1935 15' Quad #181 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  14. 1935 15' Quad #227 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  15. 1935 15' Quad #298 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  16. 1935 15' Quad #082 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  17. 1935 15' Quad #132 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  18. 1935 15' Quad #149 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  19. 1935 15' Quad #415 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  20. 1935 15' Quad #063 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...