WorldWideScience

Sample records for split-field experimental design

  1. ISR split-field magnet

    CERN Multimedia

    CERN PhotoLab

    1975-01-01

    The experimental apparatus used at intersection 4 around the Split-Field Magnet by the CERN-Bologna Collaboration (experiment R406). The plastic scintillator telescopes are used for precise pulse-height and time-of-flight measurements.

  2. Split-Field Magnet facility upgraded

    CERN Multimedia

    CERN PhotoLab

    1977-01-01

    The Split Field Magnet (SFM) was the largest spectrometer for particles from beam-beam collisions in the ISR. It could determine particle momenta in a large solid angle, but was designed mainly for the analysis of forward travelling particles.As the magnet was working on the ISR circulating beams, its magnetic field had to be such as to restore the correct proton orbit.The SFM, therefore, produced zero field at the crossing point and fields of opposite signs upstream and downstream of it and was completed by 2 large and 2 small compensator magnets. The gradient effects were corrected by magnetic channels equipped with movable flaps. The useful magnetic field volume was 28 m3, the induction in the median plane 1.14 T, the gap heigth 1.1 m, the length 10.5 m, the weight about 1000 ton. Concerning the detectors, the SFM was the first massive application of multiwire proportional chambers (about 70000 wires) which filled the main and the large compensator magnets. In 1976 an improved programme was started with tw...

  3. At the Split-Field Magnet

    CERN Multimedia

    CERN PhotoLab

    1980-01-01

    The experiments running in 1980 were R416, R418 and R421. R416 was designed by the CERN-Dortmund-Heidelberg-Karlsruhe-Paris Collège de France-Warsaw Collaboration to study rare events. On the right: the Karlsruhe calorimeter. R418 by the CERN-Heidelberg-Lund Collaboration studied p-alpha and alpha-alpha collisions. R421 by the Bologna-CERN-Frascati-Rome- Bari Collaboration aimed to the comparison of proton-antiproton with positron-electron collisions.

  4. Experimental Design Research

    DEFF Research Database (Denmark)

    This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations...... of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e.g. psychology, cognition, sociology...... research practice where methods are diverging and integration between individual, team and organizational understanding is becoming increasingly tenuous, calling for a multidisciplinary and transdiscipinary perspective. Experimental design research thus offers a powerful tool and platform for resolving...

  5. Model (1:10) of the Split-Field Magnet

    CERN Multimedia

    1977-01-01

    The photo shows Klaus Brand from the ISR BOM group with the working model of the Split-Field Magnet, while setting up the field measuring bench. The bench used Hall probes for which he had developed the electronics instrumentation (ISR-BOM Int. Note 12-01-1977). The SFM model made of mild steel with copper coils had been measured in the years 1969-1970. This new mapping campaign was related to the installation of a large calorimeter to one side of the magnet.

  6. Split Field magnet at the I4 ISR intersection

    CERN Multimedia

    1974-01-01

    The Split-Field Magnet (SFM) at I4 had an unconventional topology, consisting of two dipole magnets of opposite polarity. It formed the heart of the first general facility at the ISR. It had a useful magnetic field volume of 28 m3 and a field in the median plane of 1.14 T. With a gap height of 1.1 m and length of 10.5 m, the magnet weighed about 1000 t. The SFM spectrometer featured the first large-scale application of MWPCs (about 70,000 wires), which filled the main magnet, visible here in 1974, and the two large compensator magnets.

  7. Experimental Design Research

    DEFF Research Database (Denmark)

    This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations...... of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e.g. psychology, cognition, sociology......, computer science, management). Above all, the book emphasizes the integrative nature of design research in terms of the methods, theories, and units of study—from the individual to the organizational level. Although this approach offers many advantages, it has inherently led to a situation in current...

  8. Optimal experimental design with r

    CERN Document Server

    Rasch, Dieter; Verdooren, L R; Gebhardt, Albrecht

    2011-01-01

    Experimental design is often overlooked in the literature of applied and mathematical statistics: statistics is taught and understood as merely a collection of methods for analyzing data. Consequently, experimenters seldom think about optimal design, including prerequisites such as the necessary sample size needed for a precise answer for an experimental question. Providing a concise introduction to experimental design theory, Optimal Experimental Design with R: Introduces the philosophy of experimental design Provides an easy process for constructing experimental designs and calculating necessary sample size using R programs Teaches by example using a custom made R program package: OPDOE Consisting of detailed, data-rich examples, this book introduces experimenters to the philosophy of experimentation, experimental design, and data collection. It gives researchers and statisticians guidance in the construction of optimum experimental designs using R programs, including sample size calculations, hypothesis te...

  9. Optimal experimental design with R

    CERN Document Server

    Rasch, Dieter; Verdooren, L R; Gebhardt, Albrecht

    2011-01-01

    Experimental design is often overlooked in the literature of applied and mathematical statistics: statistics is taught and understood as merely a collection of methods for analyzing data. Consequently, experimenters seldom think about optimal design, including prerequisites such as the necessary sample size needed for a precise answer for an experimental question. Providing a concise introduction to experimental design theory, Optimal Experimental Design with R: Introduces the philosophy of experimental design Provides an easy process for constructing experimental designs and calculating necessary sample size using R programs Teaches by example using a custom made R program package: OPDOE Consisting of detailed, data-rich examples, this book introduces experimenters to the philosophy of experimentation, experimental design, and data collection. It gives researchers and statisticians guidance in the construction of optimum experimental designs using R programs, including sample size calculations, hypothesis te...

  10. Experimental Engineering: Articulating and Valuing Design Experimentation

    DEFF Research Database (Denmark)

    Vallgårda, Anna; Grönvall, Erik; Fritsch, Jonas

    2017-01-01

    In this paper we propose Experimental Engineering as a way to articulate open- ended technological experiments as a legitimate design research practice. Experimental Engineering introduces a move away from an outcome or result driven design process towards an interest in existing technologies...

  11. Study of Rare Events at the Split Field Magnet

    CERN Multimedia

    2002-01-01

    The aim of the experiment is the study of full events associated with special, rare triggers using the almost 4 @p geometry of the improved Split Field Magnet (SFM) detector. Two triggers are used: a) a trigger on an electron produced around 90|0 with a transverse momentum p^t @$>$ 0.5 GeV/c; b) a trigger on very high p^t hadrons (p^t $>$ 5 GeV/c) at @Q @C 45|0, using the SFM chambers to define roads pointing to the interaction region. In the first case, the associated event will be studied to determine the origin of direct electron production in charmed particle production. In the second case, the production of jets or jet-like objects when a high p^t particle is produced in pp collisions will be investigated. To carry out this program, the detection system consists of : \\item a) An improved SFM detector chamber system and layout to detect more of the produced particles and to simplify the pattern recognition problem in multiparticle events. \\item b) An improved program chain for the analysis of SFM events, ...

  12. Experimental and Quasi-Experimental Design.

    Science.gov (United States)

    Cottrell, Edward B.

    With an emphasis on the problems of control of extraneous variables and threats to internal and external validity, the arrangement or design of experiments is discussed. The purpose of experimentation in an educational institution, and the principles governing true experimentation (randomization, replication, and control) are presented, as are…

  13. Sudoku Squares as Experimental Designs

    Indian Academy of Sciences (India)

    IAS Admin

    number of Sudoku squares of order 9 [12]. Latin squares are used as statistical experimental de- signs that study the effect of three explanatory variables, each at n levels, on a response variable, using only n2 experimental units. In a Latin square design (LSD), the experimental units are laid out in an n × n square ar- ray.

  14. Experimental design a chemometric approach

    CERN Document Server

    Deming, SN

    1987-01-01

    Now available in a paperback edition is a book which has been described as ``...an exceptionally lucid, easy-to-read presentation... would be an excellent addition to the collection of every analytical chemist. I recommend it with great enthusiasm.'' (Analytical Chemistry). Unlike most current textbooks, it approaches experimental design from the point of view of the experimenter, rather than that of the statistician. As the reviewer in `Analytical Chemistry' went on to say: ``Deming and Morgan should be given high praise for bringing the principles of experimental design to the level of the p

  15. Design approaches to experimental mediation☆

    Science.gov (United States)

    Pirlott, Angela G.; MacKinnon, David P.

    2016-01-01

    Identifying causal mechanisms has become a cornerstone of experimental social psychology, and editors in top social psychology journals champion the use of mediation methods, particularly innovative ones when possible (e.g. Halberstadt, 2010, Smith, 2012). Commonly, studies in experimental social psychology randomly assign participants to levels of the independent variable and measure the mediating and dependent variables, and the mediator is assumed to causally affect the dependent variable. However, participants are not randomly assigned to levels of the mediating variable(s), i.e., the relationship between the mediating and dependent variables is correlational. Although researchers likely know that correlational studies pose a risk of confounding, this problem seems forgotten when thinking about experimental designs randomly assigning participants to levels of the independent variable and measuring the mediator (i.e., “measurement-of-mediation” designs). Experimentally manipulating the mediator provides an approach to solving these problems, yet these methods contain their own set of challenges (e.g., Bullock, Green, & Ha, 2010). We describe types of experimental manipulations targeting the mediator (manipulations demonstrating a causal effect of the mediator on the dependent variable and manipulations targeting the strength of the causal effect of the mediator) and types of experimental designs (double randomization, concurrent double randomization, and parallel), provide published examples of the designs, and discuss the strengths and challenges of each design. Therefore, the goals of this paper include providing a practical guide to manipulation-of-mediator designs in light of their challenges and encouraging researchers to use more rigorous approaches to mediation because manipulation-of-mediator designs strengthen the ability to infer causality of the mediating variable on the dependent variable. PMID:27570259

  16. Mounting an ISR intersection chamber in the Split Field Magnet(SFM)

    CERN Multimedia

    1977-01-01

    The Split Field Magnet (SFM) was the largest spectrometer for particles from beam-beam collisions in the ISR. It could determine particle momenta in a large solid angle, but was designed mainly for the analysis of forward travelling particles.As the magnet was working on the ISR circulating beams, its magnetic field had to be such as to restore the correct proton orbit.The SFM, therefore, produced zero field at the crossing point and fields of opposite signs upstream and downstream of it and was completed by 2 large and 2 small compensator magnets. The gradient effects were corrected by magnetic channels equipped with movable flaps. The useful magnetic field volume was 28 m3, the induction in the median plane 1.14 T, the gap heigth 1.1 m, the length 10.5 m, the weight about 1000 ton.Concerning the detectors, the SFM was the first massive application of multiwire proportional chambers (about 70000 wires) which filled the main and the large compensator magnets. In the course of the years different types of vacu...

  17. Sudoku Squares as Experimental Designs

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 20; Issue 9. Sudoku Squares as Experimental Designs. Jyotirmoy Sarkar Bikas K Sinha. General Article Volume 20 Issue 9 September 2015 pp 788-802. Fulltext. Click here to view fulltext PDF. Permanent link:

  18. Graphical Models for Quasi-Experimental Designs

    Science.gov (United States)

    Kim, Yongnam; Steiner, Peter M.; Hall, Courtney E.; Su, Dan

    2016-01-01

    Experimental and quasi-experimental designs play a central role in estimating cause-effect relationships in education, psychology, and many other fields of the social and behavioral sciences. This paper presents and discusses the causal graphs of experimental and quasi-experimental designs. For quasi-experimental designs the authors demonstrate…

  19. Quasi-Experimental Designs for Causal Inference

    Science.gov (United States)

    Kim, Yongnam; Steiner, Peter

    2016-01-01

    When randomized experiments are infeasible, quasi-experimental designs can be exploited to evaluate causal treatment effects. The strongest quasi-experimental designs for causal inference are regression discontinuity designs, instrumental variable designs, matching and propensity score designs, and comparative interrupted time series designs. This…

  20. The application of experimental design in bioengineering.

    Science.gov (United States)

    Kirkham, R L; Austin, J A

    1978-04-01

    The use of factorial designs in experimentation and the careful planning of the three basic phases of experimental projects, will maximize the reliable information from the experiment and minimize the cost and effort to the experimentor. The application of the principles of good experimental design are illustrated in a case study of experimentation which investigates a new mode of peritoneal dialysis.

  1. Experimental Design and Some Threats to Experimental Validity: A Primer

    Science.gov (United States)

    Skidmore, Susan

    2008-01-01

    Experimental designs are distinguished as the best method to respond to questions involving causality. The purpose of the present paper is to explicate the logic of experimental design and why it is so vital to questions that demand causal conclusions. In addition, types of internal and external validity threats are discussed. To emphasize the…

  2. The Experimental Design Ability Test (EDAT)

    Science.gov (United States)

    Sirum, Karen; Humburg, Jennifer

    2011-01-01

    Higher education goals include helping students develop evidence based reasoning skills; therefore, scientific thinking skills such as those required to understand the design of a basic experiment are important. The Experimental Design Ability Test (EDAT) measures students' understanding of the criteria for good experimental design through their…

  3. Experimental Design: Review and Comment.

    Science.gov (United States)

    1984-02-01

    designs in response surface studies (Box and Hunter 1957). The designs are constructed by performing a nonlinear transformation of the coordinate system...Methods for Optimization in Synthetic Chemistry: An Instructive Example with the Willgerodt Reaction," Nouveau Journal de Chimie , 7, 315-319. CARLSON, R

  4. Sudoku Squares as Experimental Designs

    Indian Academy of Sciences (India)

    IAS Admin

    numbers 1 through n such that every row, every column and every p × q internal block contains .... columns within a stack, and symmetries due to reflec- tions and rotations of the entire ..... Units: Single entities on which experimental conditions are applied and on which measurements are taken; as for example, plots in an ...

  5. Quasi experimental designs in pharmacist intervention research.

    Science.gov (United States)

    Krass, Ines

    2016-06-01

    Background In the field of pharmacist intervention research it is often difficult to conform to the rigorous requirements of the "true experimental" models, especially the requirement of randomization. When randomization is not feasible, a practice based researcher can choose from a range of "quasi-experimental designs" i.e., non-randomised and at time non controlled. Objective The aim of this article was to provide an overview of quasi-experimental designs, discuss their strengths and weaknesses and to investigate their application in pharmacist intervention research over the previous decade. Results In the literature quasi experimental studies may be classified into five broad categories: quasi-experimental design without control groups; quasi-experimental design that use control groups with no pre-test; quasi-experimental design that use control groups and pre-tests; interrupted time series and stepped wedge designs. Quasi-experimental study design has consistently featured in the evolution of pharmacist intervention research. The most commonly applied of all quasi experimental designs in the practice based research literature are the one group pre-post-test design and the non-equivalent control group design i.e., (untreated control group with dependent pre-tests and post-tests) and have been used to test the impact of pharmacist interventions in general medications management as well as in specific disease states. Conclusion Quasi experimental studies have a role to play as proof of concept, in the pilot phases of interventions when testing different intervention components, especially in complex interventions. They serve to develop an understanding of possible intervention effects: while in isolation they yield weak evidence of clinical efficacy, taken collectively, they help build a body of evidence in support of the value of pharmacist interventions across different practice settings and countries. However, when a traditional RCT is not feasible for

  6. Experimental design and priority PLS regression

    DEFF Research Database (Denmark)

    Høskuldsson, Agnar

    1996-01-01

    Rules, ideas and algorithms of the H-principle are used to analyse models that are derived from experimental design. Some of the basic ideas of experimental design are reviewed and related to the methodology of the H-principle. New methods of optimal response surfaces are developed....

  7. OSHA and Experimental Safety Design.

    Science.gov (United States)

    Sichak, Stephen, Jr.

    1983-01-01

    Suggests that a governmental agency, most likely Occupational Safety and Health Administration (OSHA) be considered in the safety design stage of any experiment. Focusing on OSHA's role, discusses such topics as occupational health hazards of toxic chemicals in laboratories, occupational exposure to benzene, and role/regulations of other agencies.…

  8. Study of ln s Physics in $\\bar{p}p$ Interactions at the Split Field Magnet

    CERN Multimedia

    2002-01-01

    This experiment uses the Split Field Magnet detector to investigate the low p^t, ``ln~s'', type of interactions that dominate the @*p cross-section. Systematic comparisons will be made to pp interactions. \\\\ \\\\ Specific areas to be studied include elastic scattering in the regions 0.05 $<$ !t! $<$ 0.8 GeV|2 and 0.8 $<$ !t! $<$ 4.0 GeV|2, and the use of a minimum bias trigger to study topological cross-sections, inclusive spectra, and two-body correlations. Some specialized triggers, run simultaneously with the high t elastic scattering trigger, are being studied. Examples are a trigger requiring Cerenkov identification in a limited region of phase space, and a trigger to select diffractively produced events.

  9. Two polynomial representations of experimental design

    OpenAIRE

    Notari, Roberto; Riccomagno, Eva; Rogantin, Maria-Piera

    2007-01-01

    In the context of algebraic statistics an experimental design is described by a set of polynomials called the design ideal. This, in turn, is generated by finite sets of polynomials. Two types of generating sets are mostly used in the literature: Groebner bases and indicator functions. We briefly describe them both, how they are used in the analysis and planning of a design and how to switch between them. Examples include fractions of full factorial designs and designs for mixture experiments.

  10. Chemicals-Based Formulation Design: Virtual Experimentations

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul

    2011-01-01

    This paper presents a systematic procedure for virtual experimentations related to the design of liquid formulated products. All the experiments that need to be performed when designing a liquid formulated product (lotion), such as ingredients selection and testing, solubility tests, property...... measurements, can now be performed through the virtual Product-Process Design laboratory [[1], [2] and [3

  11. Chemical-Based Formulation Design: Virtual Experimentation

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul

    This paper presents a software, the virtual Product-Process Design laboratory (virtual PPD-lab) and the virtual experimental scenarios for design/verification of consumer oriented liquid formulated products where the software can be used. For example, the software can be employed for the design......, the additives and/or their mixtures (formulations). Therefore, the experimental resources can focus on a few candidate product formulations to find the best product. The virtual PPD-lab allows various options for experimentations related to design and/or verification of the product. For example, the selection...... design, model adaptation). All of the above helps to perform virtual experiments by blending chemicals together and observing their predicted behaviour. The paper will highlight the application of the virtual PPD-lab in the design and/or verification of different consumer products (paint formulation...

  12. Experimental design of a waste glass study

    International Nuclear Information System (INIS)

    Piepel, G.F.; Redgate, P.E.; Hrma, P.

    1995-04-01

    A Composition Variation Study (CVS) is being performed to support a future high-level waste glass plant at Hanford. A total of 147 glasses, covering a broad region of compositions melting at approximately 1150 degrees C, were tested in five statistically designed experimental phases. This paper focuses on the goals, strategies, and techniques used in designing the five phases. The overall strategy was to investigate glass compositions on the boundary and interior of an experimental region defined by single- component, multiple-component, and property constraints. Statistical optimal experimental design techniques were used to cover various subregions of the experimental region in each phase. Empirical mixture models for glass properties (as functions of glass composition) from previous phases wee used in designing subsequent CVS phases

  13. Experimental design matters for statistical analysis

    DEFF Research Database (Denmark)

    Jensen, Signe Marie; Schaarschmidt, Frank; Onofri, Andrea

    2018-01-01

    BACKGROUND: Nowadays, the evaluation of effects of pesticides often relies on experimental designs that involve multiple concentrations of the pesticide of interest or multiple pesticides at specific comparable concentrations and, possibly, secondary factors of interest. Unfortunately, the experi...

  14. Experimental design optimization for screening relevant free ...

    African Journals Online (AJOL)

    Experimental design methodology was used to optimize the HPLC separation of various relevant phenolic acids from an artificial mixture. The effect of four characteristic factors of the HPLC procedure on the Chromatographic Response Function was investigated by a Central Composite Face-Centred Design and Multi ...

  15. Design of Formulated Products: Experimental Component

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul; Cheng, Y. S.

    2012-01-01

    : computer-aided design (Stage 1), which generates a list of feasible candidates, experimental planning (Stage 2), which generates a list of experiments and checks the available experimental set-ups, and experimental testing (Stage 3), which measures the necessary data and verifies the desirable attributes......A systematic methodology for the design and verification of chemical-based products is proposed. By integrating modeling, and experiments, the search space is efficiently scanned to identify the feasible product candidates. The product design (or verification) problem consists of three stages...... of the final product. The first stage (Stage 1) has been covered in previous publications, along with detailed case studies. The development of Stage 2 and Stage 3 is considered in this article and highlighted through two case studies involving the design and validation of an insect repellent lotion...

  16. Design activities of a fusion experimental breeder

    International Nuclear Information System (INIS)

    Huang, J.; Feng, K.; Sheng, G.

    2001-01-01

    The fusion reactor design studies in China are under the support of a fusion-fission hybrid reactor research Program. The purpose of this program is to explore the potential near-term application of fusion energy to support the long-term fusion energy on the one hand and the fission energy development on the other. During 1992-1996 a detailed consistent and integral conceptual design of a Fusion Experimental Breeder, FEB was completed. Beginning from 1996, a further design study towards an Engineering Outline Design of the FEB, FEB-E, has started. The design activities are briefly given. (author)

  17. Design activities of a fusion experimental breeder

    International Nuclear Information System (INIS)

    Huang, J.; Feng, K.; Sheng, G.

    1999-01-01

    The fusion reactor design studies in China are under the support of a fusion-fission hybrid reactor research Program. The purpose of this program is to explore the potential near-term application of fusion energy to support the long-term fusion energy on the one hand and the fission energy development on the other. During 1992-1996 a detailed consistent and integral conceptual design of a Fusion Experimental Breeder, FEB was completed. Beginning from 1996, a further design study towards an Engineering Outline Design of the FEB, FEB-E, has started. The design activities are briefly given. (author)

  18. Optimal Bayesian Experimental Design for Combustion Kinetics

    KAUST Repository

    Huan, Xun

    2011-01-04

    Experimental diagnostics play an essential role in the development and refinement of chemical kinetic models, whether for the combustion of common complex hydrocarbons or of emerging alternative fuels. Questions of experimental design—e.g., which variables or species to interrogate, at what resolution and under what conditions—are extremely important in this context, particularly when experimental resources are limited. This paper attempts to answer such questions in a rigorous and systematic way. We propose a Bayesian framework for optimal experimental design with nonlinear simulation-based models. While the framework is broadly applicable, we use it to infer rate parameters in a combustion system with detailed kinetics. The framework introduces a utility function that reflects the expected information gain from a particular experiment. Straightforward evaluation (and maximization) of this utility function requires Monte Carlo sampling, which is infeasible with computationally intensive models. Instead, we construct a polynomial surrogate for the dependence of experimental observables on model parameters and design conditions, with the help of dimension-adaptive sparse quadrature. Results demonstrate the efficiency and accuracy of the surrogate, as well as the considerable effectiveness of the experimental design framework in choosing informative experimental conditions.

  19. Experimental design in chemistry: A tutorial.

    Science.gov (United States)

    Leardi, Riccardo

    2009-10-12

    In this tutorial the main concepts and applications of experimental design in chemistry will be explained. Unfortunately, nowadays experimental design is not as known and applied as it should be, and many papers can be found in which the "optimization" of a procedure is performed one variable at a time. Goal of this paper is to show the real advantages in terms of reduced experimental effort and of increased quality of information that can be obtained if this approach is followed. To do that, three real examples will be shown. Rather than on the mathematical aspects, this paper will focus on the mental attitude required by experimental design. The readers being interested to deepen their knowledge of the mathematical and algorithmical part can find very good books and tutorials in the references [G.E.P. Box, W.G. Hunter, J.S. Hunter, Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building, John Wiley & Sons, New York, 1978; R. Brereton, Chemometrics: Data Analysis for the Laboratory and Chemical Plant, John Wiley & Sons, New York, 1978; R. Carlson, J.E. Carlson, Design and Optimization in Organic Synthesis: Second Revised and Enlarged Edition, in: Data Handling in Science and Technology, vol. 24, Elsevier, Amsterdam, 2005; J.A. Cornell, Experiments with Mixtures: Designs, Models and the Analysis of Mixture Data, in: Series in Probability and Statistics, John Wiley & Sons, New York, 1991; R.E. Bruns, I.S. Scarminio, B. de Barros Neto, Statistical Design-Chemometrics, in: Data Handling in Science and Technology, vol. 25, Elsevier, Amsterdam, 2006; D.C. Montgomery, Design and Analysis of Experiments, 7th edition, John Wiley & Sons, Inc., 2009; T. Lundstedt, E. Seifert, L. Abramo, B. Thelin, A. Nyström, J. Pettersen, R. Bergman, Chemolab 42 (1998) 3; Y. Vander Heyden, LC-GC Europe 19 (9) (2006) 469].

  20. Small Sample Experimental Design Optimization and Repair

    Energy Technology Data Exchange (ETDEWEB)

    A. J. Honson; D. DeCarli; S. V. Crowder

    1999-04-01

    The primary goal of using Design of Experiment (DOEx) methods is to extract the maximum amount of information concerning experimental factors and their interactions from as few observations as possible. DOEx methodology allows an experimenter to selectively and systematically adjust process settings to learn which factors have the greatest impact on process and product performance. Using information about these factors, process settings can be adjusted until optimum performance is obtained.

  1. Organelle proteomics experimental designs and analysis.

    Science.gov (United States)

    Gatto, Laurent; Vizcaíno, Juan Antonio; Hermjakob, Henning; Huber, Wolfgang; Lilley, Kathryn S

    2010-11-01

    In biology, localisation is function: knowledge of the localisation of proteins is of paramount importance to assess and study their function. This supports the need for reliable protein sub-cellular localisation assignment. Concomitant with recent technological advances in organelle proteomics, there is a requirement for more rigorous experimental and analysis design planning and description. In this review, we present an overview of current experimental designs in qualitative and quantitative organelle proteomics as well as associated data analysis. We also consider the major benefits associated with careful description and dissemination of the experiment and analysis designs, namely (i) comparison and optimisation of experimental designs and analysis pipelines, (ii) data validation, (iii) reproducible research, (iv) efficient repository submission and retrieval and (v) meta analysis. Formalization of experimental design and analysis work flows is of direct benefit for the organelle proteomics researchers and will result in providing organelle localisation data of highest quality for the wider research community. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Experimental design research approaches, perspectives, applications

    CERN Document Server

    Stanković, Tino; Štorga, Mario

    2016-01-01

    This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e.g. psychology, cognition, sociology, computer science, management). Above all, the book emphasizes the integrative nature of design research in terms of the methods, theories, and units of study—from the individual to the organizational level. Although this approach offers many advantages, it has inherently led to a situation in current research practice where methods are diverging and integration between individual, team and organizational under...

  3. Foundational Terminal Operations HITL: Experimental Design Slides

    Science.gov (United States)

    Rorie, Robert Conrad

    2017-01-01

    The UAS (Unmanned Aircraft Systems) in the NAS (National Airspace System) project is conducting its first investigation of UAS operations in the terminal environment. A workshop is being held to get input from key stakeholders on the experimental design and scenario development occuring for this simulation, which intends to begin data collection in September 2017. These slides cover the proposed design and methodolgy for the experiment.

  4. Ions confined in spherical dielectric cavities modeled by a splitting field-theory.

    Science.gov (United States)

    Lue, Leo; Linse, Per

    2015-04-14

    The properties of ions confined within spherical dielectric cavities are examined by a splitting field-theory and Monte Carlo simulations. Three types of cavities are considered: one possessing a uniform surface charge density, one with a uniform volume charge density, and one containing mobile ions. In all cases, mobile counterions are present within the dielectric sphere. The splitting theory is based on dividing the electrostatic interaction into long- and short-wavelength contributions and applying different approximations on the two contributions. The splitting theory works well for the case where the dielectric constant of the confining sphere is equal to or less than that of the medium external to the sphere. Nevertheless, by extending the theory with a virial expansion, the predictions are improved. However, when the dielectric constant of the confining sphere is greater than that of the medium outside the sphere, the splitting theory performs poorly, only qualitatively agreeing with the simulation data. In this case, the strong-coupling expansion does not seem to work well, and a modified mean-field theory where the counterions interact directly with only their own image charge gives improved predictions. The splitting theory works best for the system with a uniform surface charge density and worst for the system with a uniform volume charge density. Increasing the number of ions within the sphere, at a fixed radius, tends to increase the ion density near the surface of the sphere and leads to a depletion region in the sphere interior; however, varying the ion number does not lead to any qualitative changes in the performance of the splitting theory.

  5. An Introduction to Experimental Design Research

    DEFF Research Database (Denmark)

    Cash, Philip; Stanković, Tino; Štorga, Mario

    2016-01-01

    Design research brings together influences from the whole gamut of social, psychological, and more technical sciences to create a tradition of empirical study stretching back over 50 years (Horvath 2004; Cross 2007). A growing part of this empirical tradition is experimental, which has gained in ...... and significant scientific knowledge. This chapter sets the stage for these discussions by introducing experimental design research, outlining the various types of experimental approach, and explaining the role of this book in the wider methodological context.......Design research brings together influences from the whole gamut of social, psychological, and more technical sciences to create a tradition of empirical study stretching back over 50 years (Horvath 2004; Cross 2007). A growing part of this empirical tradition is experimental, which has gained...... in importance as the field has matured. As in other evolving disciplines, e.g. behavioural psychology, this maturation brings with it ever-greater scientific and methodological demands (Reiser 1939; Dorst 2008). In particular, the experimental paradigm holds distinct and significant challenges for the modern...

  6. Optimal Experimental Design for Model Discrimination

    Science.gov (United States)

    Myung, Jay I.; Pitt, Mark A.

    2009-01-01

    Models of a psychological process can be difficult to discriminate experimentally because it is not easy to determine the values of the critical design variables (e.g., presentation schedule, stimulus structure) that will be most informative in differentiating them. Recent developments in sampling-based search methods in statistics make it…

  7. Experimental area design working group summary

    International Nuclear Information System (INIS)

    Blackmore, E.W.; Louis, W.

    1989-05-01

    The charge to this working group on experimental areas concerned a number of topics related to optimum layout of the experimental areas, the design of secondary channels and spectrometers, the floor space required for experiments and the impact of remote handling requirements on site layout. Recommendations included: 1) Plan for a second proton beamline even if not installed initially; 2) Carry out a detailed engineering design of the components for the beamlines and target cell for a configuration in which two or more secondary channel front-ends are combined; 3) Keep the experimental area floor close to grade level to minimize the cost and simplify future extensions to the building as new beamlines or facilities are required; and 4) Plan to have the extraction region accessible from above for remote servicing

  8. Conceptual design of Fusion Experimental Reactor (FER)

    International Nuclear Information System (INIS)

    Tone, T.; Fujisawa, N.

    1983-01-01

    Conceptual design studies of the Fusion Experimental Reactor (FER) have been performed. The FER has an objective of achieving selfignition and demonstrating engineering feasibility as a next generation tokamak to JT-60. Various concepts of the FER have been considered. The reference design is based on a double-null divertor. Optional design studies with some attractive features based on advanced concepts such as pumped limiter and RF current drive have been carried out. Key design parameters are; fusion power of 440 MW, average neutron wall loading of 1MW/m 2 , major radius of 5.5m, plasma minor radius of 1.1m, plasma elongation of 1.5, plasma current of 5.3MA, toroidal beta of 4%, toroidal field on plasma axis of 5.7T and tritium breeding ratio of above unity

  9. Conceptual design of fusion experimental reactor (FER)

    International Nuclear Information System (INIS)

    1985-01-01

    The Fusion Experimental Reactor (FER) being developed at JAERI as a next generation tokamak to JT-60 has a major mission of realizing a self-ignited long-burning DT plasma and demonstrating engineering feasibility. During FY82 and FY83 a comprehensive and intensive conceptual design study has been conducted for a pulsed operation FER as a reference option which employs a conventional inductive current drive and a double-null divertor. In parallel with the reference design, studies have been carried out to evaluate advanced reactor concepts such as quasi-steady state operation and steady state operation based on RF current drive and pumped limiter, and comparative studies for single-null divertor/pumped limiter. This report presents major results obtained primarily from FY83 design studies, while the results of FY82 design studies are described in previous references (JAERI-M 83-213--216). (author)

  10. Fundamentals of statistical experimental design and analysis

    CERN Document Server

    Easterling, Robert G

    2015-01-01

    Professionals in all areas - business; government; the physical, life, and social sciences; engineering; medicine, etc. - benefit from using statistical experimental design to better understand their worlds and then use that understanding to improve the products, processes, and programs they are responsible for. This book aims to provide the practitioners of tomorrow with a memorable, easy to read, engaging guide to statistics and experimental design. This book uses examples, drawn from a variety of established texts, and embeds them in a business or scientific context, seasoned with a dash of humor, to emphasize the issues and ideas that led to the experiment and the what-do-we-do-next? steps after the experiment. Graphical data displays are emphasized as means of discovery and communication and formulas are minimized, with a focus on interpreting the results that software produce. The role of subject-matter knowledge, and passion, is also illustrated. The examples do not require specialized knowledge, and t...

  11. Conceptual design of fusion experimental reactor (FER)

    International Nuclear Information System (INIS)

    1984-02-01

    This report describes the engineering conceptual design of Fusion Experimental Reactor (FER) which is to be built as a next generation tokamak machine. This design covers overall reactor systems including MHD equilibrium analysis, mechanical configuration of reactor, divertor, pumped limiter, first wall/breeding blanket/shield, toroidal field magnet, poloidal field magnet, cryostat, electromagnetic analysis, vacuum system, power handling and conversion, NBI, RF heating device, tritium system, neutronics, maintenance, cooling system and layout of facilities. The engineering comparison of a divertor with pumped limiters and safety analysis of reactor systems are also conducted. (author)

  12. Split-plot designs for multistage experimentation

    DEFF Research Database (Denmark)

    Kulahci, Murat; Tyssedal, John

    2016-01-01

    Most of today’s complex systems and processes involve several stages through which input or the raw material has to go before the final product is obtained. Also in many cases factors at different stages interact. Therefore, a holistic approach for experimentation that considers all stages...... on the Kronecker product representation of orthogonal designs and can be used for any number of stages, for various numbers of subplots and for different number of subplots for each stage. The procedure is demonstrated on both regular and nonregular designs and provides the maximum number of factors that can...... be accommodated in each stage. Furthermore, split-plot designs for multistage experiments with good projective properties are also provided....

  13. Conceptual design of fusion experimental reactor (FER)

    International Nuclear Information System (INIS)

    1984-03-01

    A conceptual design study (option C) has been carried out for the fusion experimental reactor (FER). In addition to design of the tokamak reactor and associated systems based on the reference design specifications, feasibility of a water-shield reactor concept was examined as a topical study. The design study for the reference tokamak reactor has produced a reactor concept for the FER, along with major R D items for the concept, based on close examinations on thermal design, electromagnetics, neutronics and remote maintenance. Particular efforts have been directed to the area of electromagnetics. Detailed analyses with close simulation models have been performed on PF coil arrangements and configurations, shell effects of the blanket for plasma position unstability, feedback control, and eddy currents during disruptions. The major design specifications are as follows; Peak fusion power 437 MW Major radius 5.5 m Minor radius 1.1 m Plasma elongation 1.5 Plasma current 5.3 MA Toroidal beta 4 % Field on axis 5.7 T (author)

  14. Three-dimensional dose accumulation in pseudo-split-field IMRT and brachytherapy for locally advanced cervical cancer.

    Science.gov (United States)

    Sun, Baozhou; Yang, Deshan; Esthappan, Jackie; Garcia-Ramirez, Jose; Price, Samantha; Mutic, Sasa; Schwarz, Julie K; Grigsby, Perry W; Tanderup, Kari

    2015-01-01

    Dose accumulation of split-field external beam radiotherapy (EBRT) and brachytherapy (BT) is challenging because of significant EBRT and BT dose gradients in the central pelvic region. We developed a method to determine biologically effective dose parameters for combined split-field intensity-modulated radiation therapy (IMRT) and image-guided BT in locally advanced cervical cancer. Thirty-three patients treated with split-field-IMRT to 45.0-51.2 Gy in 1.6-1.8 Gy per fraction to the elective pelvic lymph nodes and to 20 Gy to the central pelvis region were included in this study. Patients received six weekly fractions of high-dose rate BT to 6.5-7.3 Gy per fraction. A dose tracker software was developed to compute the equivalent dose in 2-Gy fractions (EQD2) to gross tumor volume (GTV), organs-at-risk and point A. Total dose-volume histogram parameters were computed on the 3D combined EQD2 dose based on rigid image registration. The dose accumulation uncertainty introduced by organ deformations between IMRT and BT was evaluated. According to International Commission on Radiation Unit and Measurement and GEC European Society for Therapeutic Radiology and Oncology recommendations, D98, D90, D50, and D2cm3 EQD2 dose-volume histogram parameters were computed. GTV D98 was 84.0 ± 26.5 Gy and D2cc was 99.6 ± 13.9 Gy, 67.4 ± 12.2 Gy, 75.0 ± 10.1 Gy, for bladder, rectum, and sigmoid, respectively. The uncertainties induced by organ deformation were estimated to be -1 ± 4 Gy, -3 ± 5 Gy, 2 ± 3 Gy, and -3 ± 5 Gy for bladder, rectum, sigmoid, and GTV, respectively. It is feasible to perform 3D EQD2 dose accumulation to assess high and intermediate dose regions for combined split-field IMRT and BT. Copyright © 2015 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  15. Set membership experimental design for biological systems

    Directory of Open Access Journals (Sweden)

    Marvel Skylar W

    2012-03-01

    Full Text Available Abstract Background Experimental design approaches for biological systems are needed to help conserve the limited resources that are allocated for performing experiments. The assumptions used when assigning probability density functions to characterize uncertainty in biological systems are unwarranted when only a small number of measurements can be obtained. In these situations, the uncertainty in biological systems is more appropriately characterized in a bounded-error context. Additionally, effort must be made to improve the connection between modelers and experimentalists by relating design metrics to biologically relevant information. Bounded-error experimental design approaches that can assess the impact of additional measurements on model uncertainty are needed to identify the most appropriate balance between the collection of data and the availability of resources. Results In this work we develop a bounded-error experimental design framework for nonlinear continuous-time systems when few data measurements are available. This approach leverages many of the recent advances in bounded-error parameter and state estimation methods that use interval analysis to generate parameter sets and state bounds consistent with uncertain data measurements. We devise a novel approach using set-based uncertainty propagation to estimate measurement ranges at candidate time points. We then use these estimated measurements at the candidate time points to evaluate which candidate measurements furthest reduce model uncertainty. A method for quickly combining multiple candidate time points is presented and allows for determining the effect of adding multiple measurements. Biologically relevant metrics are developed and used to predict when new data measurements should be acquired, which system components should be measured and how many additional measurements should be obtained. Conclusions The practicability of our approach is illustrated with a case study. This

  16. Experimental Design for the LATOR Mission

    Science.gov (United States)

    Turyshev, Slava G.; Shao, Michael; Nordtvedt, Kenneth, Jr.

    2004-01-01

    This paper discusses experimental design for the Laser Astrometric Test Of Relativity (LATOR) mission. LATOR is designed to reach unprecedented accuracy of 1 part in 10(exp 8) in measuring the curvature of the solar gravitational field as given by the value of the key Eddington post-Newtonian parameter gamma. This mission will demonstrate the accuracy needed to measure effects of the next post-Newtonian order (near infinity G2) of light deflection resulting from gravity s intrinsic non-linearity. LATOR will provide the first precise measurement of the solar quadrupole moment parameter, J(sub 2), and will improve determination of a variety of relativistic effects including Lense-Thirring precession. The mission will benefit from the recent progress in the optical communication technologies the immediate and natural step above the standard radio-metric techniques. The key element of LATOR is a geometric redundancy provided by the laser ranging and long-baseline optical interferometry. We discuss the mission and optical designs, as well as the expected performance of this proposed mission. LATOR will lead to very robust advances in the tests of Fundamental physics: this mission could discover a violation or extension of general relativity, or reveal the presence of an additional long range interaction in the physical law. There are no analogs to the LATOR experiment; it is unique and is a natural culmination of solar system gravity experiments.

  17. Flow cytometry: design, development and experimental validation

    International Nuclear Information System (INIS)

    Seigneur, Alain

    1987-01-01

    The flow cytometry techniques allow the analysis and sorting of living biologic cells at rates above five to ten thousand events per second. After a short review, we present in this report the design and development of a 'high-tech' apparatus intended for research laboratories and the experimental results. The first part deals with the physical principles allowing morphologic and functional analysis of cells or cellular components. The measured parameters are as follows: electrical resistance pulse sizing, light scattering and fluorescence. Hydrodynamic centering is used, and in the same way, the division of a water-stream into droplets leading to electrostatic sorting of particles. The second part deals with the apparatus designed by the 'Commissariat a l'Energie Atomique' (C.E.A.) and industrialised by 'ODAM' (ATC 3000). The last part of this thesis work is the performance evaluations of this cyto-meter. The difference between the two size measurement methods are analyzed: electrical resistance pulse sizing versus small-angle light scattering. By an original optics design, high sensitivity has been reached in the fluorescence measurement: the equivalent noise corresponds to six hundred fluorescein isothiocyanate (FITC) molecules. The sorting performances have also been analyzed and the cell viability proven. (author) [fr

  18. Design of experimental equipment at CRNL

    International Nuclear Information System (INIS)

    Godden, B.

    1976-01-01

    The Plant Design Division provides a design service to the research and development effort at CRNL. Severe constraints, both environmentally and spatially, are placed on the design of special equipment. Several examples are given. Finally, the use of automated drafting systems is described. (author)

  19. Efficient experimental designs for sigmoidal growth models

    OpenAIRE

    Dette, Holger; Pepelyshev, Andrey

    2005-01-01

    For the Weibull- and Richards-regression model robust designs are determined by maximizing a minimum of D- or D1-efficiencies, taken over a certain range of the non-linear parameters. It is demonstrated that the derived designs yield a satisfactory solution of the optimal design problem for this type of model in the sense that these designs are efficient and robust with respect to misspecification of the unknown parameters. Moreover, the designs can also be used for testing the postulated for...

  20. Revised design for the Tokamak experimental power reactor

    Energy Technology Data Exchange (ETDEWEB)

    Stacey, W.M. Jr.; Abdou, M.A.; Brooks, J.N.

    1977-03-01

    A new, preliminary design has been identified for the tokamak experimental power reactor (EPR). The revised EPR design is simpler, more compact, less expensive and has somewhat better performance characteristics than the previous design, yet retains many of the previously developed design concepts. This report summarizes the principle features of the new EPR design, including performance and cost.

  1. Conceptual design report, CEBAF basic experimental equipment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-04-13

    The Continuous Electron Beam Accelerator Facility (CEBAF) will be dedicated to basic research in Nuclear Physics using electrons and photons as projectiles. The accelerator configuration allows three nearly continuous beams to be delivered simultaneously in three experimental halls, which will be equipped with complementary sets of instruments: Hall A--two high resolution magnetic spectrometers; Hall B--a large acceptance magnetic spectrometer; Hall C--a high-momentum, moderate resolution, magnetic spectrometer and a variety of more dedicated instruments. This report contains a short description of the initial complement of experimental equipment to be installed in each of the three halls.

  2. Experimental Validation of an Integrated Controls-Structures Design Methodology

    Science.gov (United States)

    Maghami, Peiman G.; Gupta, Sandeep; Elliot, Kenny B.; Walz, Joseph E.

    1996-01-01

    The first experimental validation of an integrated controls-structures design methodology for a class of large order, flexible space structures is described. Integrated redesign of the controls-structures-interaction evolutionary model, a laboratory testbed at NASA Langley, was described earlier. The redesigned structure was fabricated, assembled in the laboratory, and experimentally tested against the original structure. Experimental results indicate that the structure redesigned using the integrated design methodology requires significantly less average control power than the nominal structure with control-optimized designs, while maintaining the required line-of-sight pointing performance. Thus, the superiority of the integrated design methodology over the conventional design approach is experimentally demonstrated. Furthermore, amenability of the integrated design structure to other control strategies is evaluated, both analytically and experimentally. Using Linear-Quadratic-Guassian optimal dissipative controllers, it is observed that the redesigned structure leads to significantly improved performance with alternate controllers as well.

  3. Experimental testing of designated driver cues

    Science.gov (United States)

    2000-07-27

    In theory, the designated-driver concept holds great promise for reducing the incidences of drunk driving. It is simple, inexpensive, almost universally recognized, and generally positively regarded by the U.S. population as a means for avoiding drun...

  4. Experimental design methods for fermentative hydrogen production: A review

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jianlong; Wan, Wei [Laboratory of Environmental Technology, INET, Tsinghua University, Beijing 100084 (China)

    2009-01-15

    This review summarized the experimental design methods used to investigate the effects of various factors on fermentative hydrogen production processes, including one-factor-at-a-time design, full factorial design, Taguchi design, Plackett-Burman design, central composite design and Box-Behnken design. Each design method was briefly introduced, followed by the introduction of its analysis. In addition, the advantages and disadvantages of each design method were briefly discussed. Moreover, the application of each design method to the study of fermentative hydrogen production was analyzed and discussed. Based on the discussion in this review, an experimental design strategy for optimizing fermentative hydrogen production processes was proposed. In the end, the software packages that can carry out the above mentioned factorial design and analysis were briefly introduced. (author)

  5. Split-field vs extended-field intensity-modulated radiation therapy plans for oropharyngeal cancer: Which spares the larynx? Which spares the thyroid?

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Yao; Chen, Josephine [Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA (United States); Leary, Celeste I. [Department of Radiation Medicine, Oregon Health Sciences University, Portland, OR (United States); Shugard, Erin [Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA (United States); Yom, Sue S., E-mail: yoms@radonc.ucsf.edu [Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA (United States); Department of Otolaryngology—Head and Neck Surgery, University of California, San Francisco, San Francisco, CA (United States)

    2016-07-01

    Radiation of the low neck can be accomplished using split-field intensity-modulated radiation therapy (sf-IMRT) or extended-field intensity-modulated radiation therapy (ef-IMRT). We evaluated the effect of these treatment choices on target coverage and thyroid and larynx doses. Using data from 14 patients with cancers of the oropharynx, we compared the following 3 strategies for radiating the low neck: (1) extended-field IMRT, (2) traditional split-field IMRT with an initial cord-junction block to 40 Gy, followed by a full-cord block to 50 Gy, and (3) split-field IMRT with a full-cord block to 50 Gy. Patients were planned using each of these 3 techniques. To facilitate comparison, extended-field plans were normalized to deliver 50 Gy to 95% of the neck volume. Target coverage was assessed using the dose to 95% of the neck volume (D{sub 95}). Mean thyroid and larynx doses were computed. Extended-field IMRT was used as the reference arm; the mean larynx dose was 25.7 ± 7.4 Gy, and the mean thyroid dose was 28.6 ± 2.4 Gy. Split-field IMRT with 2-step blocking reduced laryngeal dose (mean larynx dose 15.2 ± 5.1 Gy) at the cost of a moderate reduction in target coverage (D{sub 95} 41.4 ± 14 Gy) and much higher thyroid dose (mean thyroid dose 44.7 ± 3.7 Gy). Split-field IMRT with initial full-cord block resulted in greater laryngeal sparing (mean larynx dose 14.2 ± 5.1 Gy) and only a moderately higher thyroid dose (mean thyroid dose 31 ± 8 Gy) but resulted in a significant reduction in target coverage (D{sub 95} 34.4 ± 15 Gy). Extended-field IMRT comprehensively covers the low neck and achieves acceptable thyroid and laryngeal sparing. Split-field IMRT with a full-cord block reduces laryngeal doses to less than 20 Gy and spares the thyroid, at the cost of substantially reduced coverage of the low neck. Traditional 2-step split-field IMRT similarly reduces the laryngeal dose but also reduces low-neck coverage and delivers very high doses to the thyroid.

  6. Systematic Experimental Designs For Mixed-species Plantings

    Science.gov (United States)

    Jeffery C. Goelz

    2001-01-01

    Systematic experimental designs provide splendid demonstration areas for scientists and land managers to observe the effects of a gradient of species composition. Systematic designs are based on large plots where species composition varies gradually. Systematic designs save considerable space and require many fewer seedlings than conventional mixture designs. One basic...

  7. Using the Movies to Illustrate the Principles of Experimental Design

    Science.gov (United States)

    Strelan, Peter

    2018-01-01

    This article presents an innovative technique for teaching the principles of experimental design in a way that is entertaining and engaging for students. Following a lecture on experimental design, students participate in an experiment in which the teacher uses a funny segment from a movie to test the influence of implicit social norms. Randomly…

  8. The Implications of "Contamination" for Experimental Design in Education

    Science.gov (United States)

    Rhoads, Christopher H.

    2011-01-01

    Experimental designs that randomly assign entire clusters of individuals (e.g., schools and classrooms) to treatments are frequently advocated as a way of guarding against contamination of the estimated average causal effect of treatment. However, in the absence of contamination, experimental designs that randomly assign intact clusters to…

  9. A framework for efficient process development using optimal experimental designs

    NARCIS (Netherlands)

    Ven, P. van de; Bijlsma, S.; Gout, E.; Voort Maarschalk, K. van der; Thissen, U.

    2011-01-01

    Introduction: The aim of this study was to develop and demonstrate a framework assuring efficient process development using fewer experiments than standard experimental designs. Methods: A novel optimality criterion for experimental designs (Iw criterion) is defined that leads to more efficient

  10. Teaching Experimental Design to Elementary School Pupils in Greece

    Science.gov (United States)

    Karampelas, Konstantinos

    2016-01-01

    This research is a study about the possibility to promote experimental design skills to elementary school pupils. Experimental design and the experiment process are foundational elements in current approaches to Science Teaching, as they provide learners with profound understanding about knowledge construction and science inquiry. The research was…

  11. A Framework for Efficient Process Development Using Optimal Experimental Designs

    NARCIS (Netherlands)

    van de Ven, Peter; Bijlsma, Sabina; Gout, Erik; Maarschalk, Kees van der Voort; Thissen, Uwe

    Introduction The aim of this study was to develop and demonstrate a framework assuring efficient process development using fewer experiments than standard experimental designs. Methods A novel optimality criterion for experimental designs (Iw criterion) is defined that leads to more efficient

  12. Development of the Biological Experimental Design Concept Inventory (BEDCI)

    Science.gov (United States)

    Deane, Thomas; Nomme, Kathy; Jeffery, Erica; Pollock, Carol; Birol, Gulnur

    2014-01-01

    Interest in student conception of experimentation inspired the development of a fully validated 14-question inventory on experimental design in biology (BEDCI) by following established best practices in concept inventory (CI) design. This CI can be used to diagnose specific examples of non-expert-like thinking in students and to evaluate the…

  13. On experimentation across science, design and society

    DEFF Research Database (Denmark)

    Boris, Stefan Darlan

    2016-01-01

    The article describes how the principal idea behind the landscape laboratories has been to develop a 1:1 platform where researchers, practitioners and lay people can meet and cooperate on the development and testing of new design concepts for establishing and managing urban landscapes. This is so......The article describes how the principal idea behind the landscape laboratories has been to develop a 1:1 platform where researchers, practitioners and lay people can meet and cooperate on the development and testing of new design concepts for establishing and managing urban landscapes...

  14. Irradiation Design for an Experimental Murine Model

    International Nuclear Information System (INIS)

    Ballesteros-Zebadua, P.; Moreno-Jimenez, S.; Suarez-Campos, J. E.; Celis, M. A.; Larraga-Gutierrez, J. M.; Garcia-Garduno, O. A.; Rubio-Osornio, M. C.; Custodio-Ramirez, V.; Paz, C.

    2010-01-01

    In radiotherapy and stereotactic radiosurgery, small animal experimental models are frequently used, since there are still a lot of unsolved questions about the biological and biochemical effects of ionizing radiation. This work presents a method for small-animal brain radiotherapy compatible with a dedicated 6MV Linac. This rodent model is focused on the research of the inflammatory effects produced by ionizing radiation in the brain. In this work comparisons between Pencil Beam and Monte Carlo techniques, were used in order to evaluate accuracy of the calculated dose using a commercial planning system. Challenges in this murine model are discussed.

  15. Human Factors Experimental Design and Analysis Reference

    Science.gov (United States)

    2007-07-01

    8.75 83.36 8 =where, tObserved YPD = 53.75 YSD = 62.00 3.6.5. Within-Subjects t-Test (Cont’d) (Click in this red rectangle to see SAS calculations...expands computer experience into 3 levels, High, Medium , and Low, as compared to the original example that used only 2 levels of computer experience...High and Low. In this example, each of the 80 subjects who used the experimental text editor rated their computer experience as high, medium , or

  16. Internal split field generator

    Science.gov (United States)

    Thundat,; George, Thomas [Knoxville, TN; Van Neste, Charles W [Kingston, TN; Vass, Arpad Alexander [Oak Ridge, TN

    2012-01-03

    A generator includes a coil of conductive material. A stationary magnetic field source applies a stationary magnetic field to the coil. An internal magnetic field source is disposed within a cavity of the coil to apply a moving magnetic field to the coil. The stationary magnetic field interacts with the moving magnetic field to generate an electrical energy in the coil.

  17. External split field generator

    Science.gov (United States)

    Thundat, Thomas George [Knoxville, TN; Van Neste, Charles W [Kingston, TN; Vass, Arpad Alexander [Oak Ridge, TN

    2012-02-21

    A generator includes a coil disposed about a core. A first stationary magnetic field source may be disposed on a first end portion of the core and a second stationary magnetic field source may be disposed on a second end portion of core. The first and second stationary magnetic field sources apply a stationary magnetic field to the coil. An external magnetic field source may be disposed outside the coil to apply a moving magnetic field to the coil. Electrical energy is generated in response to an interaction between the coil, the moving magnetic field, and the stationary magnetic field.

  18. Experimental Design: Utilizing Microsoft Mathematics in Teaching and Learning Calculus

    Science.gov (United States)

    Oktaviyanthi, Rina; Supriani, Yani

    2015-01-01

    The experimental design was conducted to investigate the use of Microsoft Mathematics, free software made by Microsoft Corporation, in teaching and learning Calculus. This paper reports results from experimental study details on implementation of Microsoft Mathematics in Calculus, students' achievement and the effects of the use of Microsoft…

  19. Design Issues and Inference in Experimental L2 Research

    Science.gov (United States)

    Hudson, Thom; Llosa, Lorena

    2015-01-01

    Explicit attention to research design issues is essential in experimental second language (L2) research. Too often, however, such careful attention is not paid. This article examines some of the issues surrounding experimental L2 research and its relationships to causal inferences. It discusses the place of research questions and hypotheses,…

  20. Methods for the neutronic design of a Supersara experimental loop

    International Nuclear Information System (INIS)

    Casali, F.; Cepraga, D.

    1982-01-01

    This paper describes a method for the neutronic design of experimental loops irradiated in D 2 O experimental reactors, like Essor. The calculation approach concerns the definition of a Weigner-Seitz cell where the loop under examination be subjected to the same neutronic conditions as in the actual reactor

  1. Active Photonic Crystal Switches: Modeling, Design and Experimental Characterization

    DEFF Research Database (Denmark)

    Heuck, Mikkel; Yu, Yi; Kristensen, Philip Trøst

    2013-01-01

    In this paper, we present recent progress in modeling, design, fabrication and experimental characterization of InP photonic crystal all-optical switches. Novel designs with increased flexibility and performance are presented, and their operation using high speed data signals is analyzed...

  2. Randomizing Roaches: Exploring the "Bugs" of Randomization in Experimental Design

    Science.gov (United States)

    Wagler, Amy; Wagler, Ron

    2014-01-01

    Understanding the roles of random selection and random assignment in experimental design is a central learning objective in most introductory statistics courses. This article describes an activity, appropriate for a high school or introductory statistics course, designed to teach the concepts, values and pitfalls of random selection and assignment…

  3. Experimental and numerical analysis for optimal design parameters ...

    Indian Academy of Sciences (India)

    In this context, response surface methodology is employed by aid of design of experiment approach. Later, the response surface curves are studied using ANOVA. Finally, the relations established are confirmed experimentally to validate the models. The relations thus established are beneficent in furtherance of designing ...

  4. Experimental Methodology in English Teaching and Learning: Method Features, Validity Issues, and Embedded Experimental Design

    Science.gov (United States)

    Lee, Jang Ho

    2012-01-01

    Experimental methods have played a significant role in the growth of English teaching and learning studies. The paper presented here outlines basic features of experimental design, including the manipulation of independent variables, the role and practicality of randomised controlled trials (RCTs) in educational research, and alternative methods…

  5. Design of an experimental set up for convective drying: experimental studies at different drying temperature

    Science.gov (United States)

    Mohan, V. P. Chandra; Talukdar, Prabal

    2013-01-01

    An experimental setup is designed to investigate the convective drying of moist object experimentally. All the design data, components of setup, materials and specifications are presented. Transient moisture content of a rectangular shaped potato slice (4 × 2 × 2 cm) is measured at different air temperatures of 40, 50, 60 and 70 °C with an air velocity of 2 m/s. Two different drying rate periods are observed. Results are compared with available results from literature.

  6. Optimal experimental designs for inverse quadratic regression models

    OpenAIRE

    Dette, Holger; Kiss, Christine

    2007-01-01

    In this paper optimal experimental designs for inverse quadratic regression models are determined. We consider two different parameterizations of the model and investigate local optimal designs with respect to the $c$-, $D$- and $E$-criteria, which reflect various aspects of the precision of the maximum likelihood estimator for the parameters in inverse quadratic regression models. In particular it is demonstrated that for a sufficiently large design space geometric allocation rules are optim...

  7. Optimal Experimental Design of Furan Shock Tube Kinetic Experiments

    KAUST Repository

    Kim, Daesang

    2015-01-07

    A Bayesian optimal experimental design methodology has been developed and applied to refine the rate coefficients of elementary reactions in Furan combustion. Furans are considered as potential renewable fuels. We focus on the Arrhenius rates of Furan + OH ↔ Furyl-2 + H2O and Furan ↔ OH Furyl-3 + H2O, and rely on the OH consumption rate as experimental observable. A polynomial chaos surrogate is first constructed using an adaptive pseudo-spectral projection algorithm. The PC surrogate is then exploited in conjunction with a fast estimation of the expected information gain in order to determine the optimal design in the space of initial temperatures and OH concentrations.

  8. Computer-Generated Experimental Designs for Irregular-Shaped Regions

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Nam K.; Piepel, Gregory F.

    2005-09-01

    This paper focuses on the construction of computer-generated designs on irregularly-shaped, constrained regions. Overviews of the Fedorov exchange algorithm (FEA) and other exchange algorithms for the construction of D-optimal designs are given. A faster implementation of the FEA is presented, which is referred to as fast-FEA (denoted FFEA). The FFEA was applied to construct D-optimal designs for several published examples with constrained experimental regions. Designs resulting from the FFEA are more D-efficient than published designs, and provide benchmarks for future comparisons of design construction algorithms. The construction of G-optimal designs for constrained regions is also discussed and illustrated with a published example.

  9. Conceptual design study of Fusion Experimental Reactor (FY87FER)

    International Nuclear Information System (INIS)

    1988-05-01

    The design study of Fusion Experimental Reactor(FER) which has been proposed to be the next step fusion device has been conducted by JAERI Reactor System Laboratory since 1982 and by FER design team since 1984. This is the final report of the FER design team program and describes the results obtained in FY1987 (partially in FY1986) activities. The contents of this report consist of the reference design which is based on the guideline in FY1986 by the Subcomitees set up in Nuclear Fusion Council of Atomic Energy Commission of Japan, the Low-Physics-Risk reactor design for achieving physics mission more reliably and the system study of FER design candidates including above two designs. (author)

  10. Neural Network Assisted Experimental Designs for Food Research

    Directory of Open Access Journals (Sweden)

    H.S. Ramaswamy

    2000-06-01

    Full Text Available The ability of artificial neural networks (ANN in predicting full factorial data from the fractional data corresponding to some of the commonly used experimental designs is explored in this paper. Factorial and fractional factorial designs such as L8, L9, L18, and Box and Behnken schemes were considered both in their original form and with some variations (L8+6, L15 and L9+1. Full factorial (3 factors x 5 levels and fractional data were generated employing sixteen different mathematical equations (four in each category: linear, with and without interactions, and non-linear, with and without interactions. Different ANN models were trained and the best model was chosen for each equation based on their ability to predict the fractional data. The best experimental design was then chosen based on their ability to simulate the full- factorial data for each equation. In several cases, the mean relative errors with the L18 design (which had more input data than other models were even higher than with other smaller fractional design. In general, the ANN assisted Lm, Box and Behnken, L15 and L18 designs were found to predict the full factorial data reasonably well with errors less than 5 %. The L8+6 model performed well with several experimental datasets reported in the literature.

  11. Experimental Design to Evaluate Directed Adaptive Mutation in Mammalian Cells

    Science.gov (United States)

    Chiaro, Christopher R; May, Tobias

    2014-01-01

    Background We describe the experimental design for a methodological approach to determine whether directed adaptive mutation occurs in mammalian cells. Identification of directed adaptive mutation would have profound practical significance for a wide variety of biomedical problems, including disease development and resistance to treatment. In adaptive mutation, the genetic or epigenetic change is not random; instead, the presence and type of selection influences the frequency and character of the mutation event. Adaptive mutation can contribute to the evolution of microbial pathogenesis, cancer, and drug resistance, and may become a focus of novel therapeutic interventions. Objective Our experimental approach was designed to distinguish between 3 types of mutation: (1) random mutations that are independent of selective pressure, (2) undirected adaptive mutations that arise when selective pressure induces a general increase in the mutation rate, and (3) directed adaptive mutations that arise when selective pressure induces targeted mutations that specifically influence the adaptive response. The purpose of this report is to introduce an experimental design and describe limited pilot experiment data (not to describe a complete set of experiments); hence, it is an early report. Methods An experimental design based on immortalization of mouse embryonic fibroblast cells is presented that links clonal cell growth to reversal of an inactivating polyadenylation site mutation. Thus, cells exhibit growth only in the presence of both the countermutation and an inducing agent (doxycycline). The type and frequency of mutation in the presence or absence of doxycycline will be evaluated. Additional experimental approaches would determine whether the cells exhibit a generalized increase in mutation rate and/or whether the cells show altered expression of error-prone DNA polymerases or of mismatch repair proteins. Results We performed the initial stages of characterizing our system

  12. Use of Experimental Design for Peuhl Cheese Process Optimization ...

    African Journals Online (AJOL)

    Devika

    solids is 42.75 %. Furthermore, this work has showed that the experimental design is more suitable than the traditional study method called “one factor at a time”. @JASEM. Since two decades, the Côte d'Ivoire (Ivory Coast), has initiated an intensive development program, in the purposes of (DCGTX and MINAGRA, 1988):.

  13. Use of Experimental Design for Peuhl Cheese Process Optimization ...

    African Journals Online (AJOL)

    This work points out the use of experimental design for peulh cheese making process optimisation. Peulh cheese, a milk coagulum, well-known in certain West African countries (e.g. Benin), is unfortunately ill-known in Côte d'Ivoire (Ivory Coast). However, it could be a transformation way of milk. This work consisting in use ...

  14. Applications of Chemiluminescence in the Teaching of Experimental Design

    Science.gov (United States)

    Krawczyk, Tomasz; Slupska, Roksana; Baj, Stefan

    2015-01-01

    This work describes a single-session laboratory experiment devoted to teaching the principles of factorial experimental design. Students undertook the rational optimization of a luminol oxidation reaction, using a two-level experiment that aimed to create a long-lasting bright emission. During the session students used only simple glassware and…

  15. Experimental design of natural and accellerated bone and wood ageing

    DEFF Research Database (Denmark)

    Facorellis, Y.; Pournou, A.; Richter, Jane

    2015-01-01

    This paper presents the experimental design for natural and accelerated ageing of bone and wood samples found in museum conditions that was conceived as part of the INVENVORG (Thales Research Funding Program – NRSF) investigating the effects of the environmental factors on natural organic materials....

  16. A Short Guide to Experimental Design and Analysis for Engineers

    Science.gov (United States)

    2014-04-01

    2011) Statistical Analysis : Microsoft Excel 2010. Indianapolis, Que Publishing Coakes, S. J. and Ong, C. (2011) SPSS : Analysis without Anguish ...UNCLASSIFIED UNCLASSIFIED A Short Guide to Experimental Design and Analysis for Engineers Edward H. S. Lo, T. Andrew Au and...Peter J. Hoek Joint and Operations Analysis Division Defence Science and Technology Organisation DSTO-TN-1291 ABSTRACT An experiment

  17. Optimal Experimental Design for Large-Scale Bayesian Inverse Problems

    KAUST Repository

    Ghattas, Omar

    2014-01-06

    We develop a Bayesian framework for the optimal experimental design of the shock tube experiments which are being carried out at the KAUST Clean Combustion Research Center. The unknown parameters are the pre-exponential parameters and the activation energies in the reaction rate expressions. The control parameters are the initial mixture composition and the temperature. The approach is based on first building a polynomial based surrogate model for the observables relevant to the shock tube experiments. Based on these surrogates, a novel MAP based approach is used to estimate the expected information gain in the proposed experiments, and to select the best experimental set-ups yielding the optimal expected information gains. The validity of the approach is tested using synthetic data generated by sampling the PC surrogate. We finally outline a methodology for validation using actual laboratory experiments, and extending experimental design methodology to the cases where the control parameters are noisy.

  18. Modeling of Cracked Beams by the Experimental Design Method

    Directory of Open Access Journals (Sweden)

    M. Serier

    Full Text Available Abstract The understanding of phenomena, no matter their nature is based on the experimental results found. In the most cases, this requires an important number of tests in order to put a reliable and useful observation served into solving the technical problems subsequently. This paper is based on independent and variables combination resulting from experimentation in a mathematical formulation. Indeed, mathematical modeling gives us the advantage to optimize and predict the right choices without passing each case by the experiment. In this work we plan to apply the experimental design method on the experimental results found by (Deokar, A, 2011, concerning the effect of the size and position of a crack on the measured frequency of a beam console, and validating the mathematical model to predict other frequencies

  19. Design of Pump as Turbine Experimental Test Facility

    Directory of Open Access Journals (Sweden)

    Zariatin D. L.

    2017-01-01

    Full Text Available This paper presents the design process of experimental test facility for pump as turbine hydropower system. Three design possibilities that related to the PAT condition of operation was developed and analyzed by using CFD Software. It is found that the First Variant with a straight flow to the PAT will produce higher velocity, which is needed to generate more rotation of the shaft generator, in order to generate more electric power. The strength of PAT construction was analyzed by using FEM software. It was found that the maximum stress is 6 MPa and can be concluded that the construction is appropriate to the design requirement.

  20. Quasi-experimental study designs series-paper 9: collecting data from quasi-experimental studies.

    Science.gov (United States)

    Aloe, Ariel M; Becker, Betsy Jane; Duvendack, Maren; Valentine, Jeffrey C; Shemilt, Ian; Waddington, Hugh

    2017-09-01

    To identify variables that must be coded when synthesizing primary studies that use quasi-experimental designs. All quasi-experimental (QE) designs. When designing a systematic review of QE studies, potential sources of heterogeneity-both theory-based and methodological-must be identified. We outline key components of inclusion criteria for syntheses of quasi-experimental studies. We provide recommendations for coding content-relevant and methodological variables and outlined the distinction between bivariate effect sizes and partial (i.e., adjusted) effect sizes. Designs used and controls used are viewed as of greatest importance. Potential sources of bias and confounding are also addressed. Careful consideration must be given to inclusion criteria and the coding of theoretical and methodological variables during the design phase of a synthesis of quasi-experimental studies. The success of the meta-regression analysis relies on the data available to the meta-analyst. Omission of critical moderator variables (i.e., effect modifiers) will undermine the conclusions of a meta-analysis. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Computational design and experimental validation of new thermal barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin [Louisiana State Univ., Baton Rouge, LA (United States)

    2015-03-31

    The focus of this project is on the development of a reliable and efficient ab initio based computational high temperature material design method which can be used to assist the Thermal Barrier Coating (TBC) bond-coat and top-coat design. Experimental evaluations on the new TBCs are conducted to confirm the new TBCs’ properties. Southern University is the subcontractor on this project with a focus on the computational simulation method development. We have performed ab initio density functional theory (DFT) method and molecular dynamics simulation on screening the top coats and bond coats for gas turbine thermal barrier coating design and validation applications. For experimental validations, our focus is on the hot corrosion performance of different TBC systems. For example, for one of the top coatings studied, we examined the thermal stability of TaZr2.75O8 and confirmed it’s hot corrosion performance.

  2. MYRRHA/XT-ADS primary system design and experimental devices

    International Nuclear Information System (INIS)

    Maes, D.

    2009-01-01

    The EUROTRANS project is an integrated project in the Sixth European Framework Program in the context of Partitioning and Transmutation. The objective of this project is to work towards an ETD (European Transmutation Demonstration) in a step-wise manner. The first step is to carry out an advanced design of a small-scale XT-ADS (eXperimental Transmutation in an Accelerator Driven System) for realisation in a short-term (about 10 years) as well as to accomplish a generic conceptual design of EFIT (European Facility for Industrial Transmutation) for realisation in the long-term. The MYRRHA-2005 design served as a starting basis for the XT-ADS. Many options have been revisited and the framework is now set up. While the MYRRHA-2005 design was still a conceptual design, the intention is to get at the end of the EUROTRANS project (March 2009) an advanced design of the XT-ADS, albeit a first advanced design. While the design work performed during the first years of the project (2005-2006) was mainly devoted to optimise and enhance the primary and secondary system configuration according to the suggestions and contributions of our industrial partners (Ansaldo Nucleare, Areva, Suez-Tractebel) within the DM1 (Domain 1 D ESIGN ) , the last year work objectives mainly consisted of (1) the release of the Remote Handling Design Catalogue for XT-ADS and (2) the formulation of the specification of the experimental devices according to the XT-ADS objectives and adapted to the actual XT-ADS core and core support structure design; (3) the detailed calculations of the main XT-ADS primary and secondary system components

  3. Optimizing an experimental design for an electromagnetic experiment

    Science.gov (United States)

    Roux, Estelle; Garcia, Xavier

    2013-04-01

    Most of geophysical studies focus on data acquisition and analysis, but another aspect which is gaining importance is the discussion on acquisition of suitable datasets. This can be done through the design of an optimal experiment. Optimizing an experimental design implies a compromise between maximizing the information we get about the target and reducing the cost of the experiment, considering a wide range of constraints (logistical, financial, experimental …). We are currently developing a method to design an optimal controlled-source electromagnetic (CSEM) experiment to detect a potential CO2 reservoir and monitor this reservoir during and after CO2 injection. Our statistical algorithm combines the use of linearized inverse theory (to evaluate the quality of one given design via the objective function) and stochastic optimization methods like genetic algorithm (to examine a wide range of possible surveys). The particularity of our method is that it uses a multi-objective genetic algorithm that searches for designs that fit several objective functions simultaneously. One main advantage of this kind of technique to design an experiment is that it does not require the acquisition of any data and can thus be easily conducted before any geophysical survey. Our new experimental design algorithm has been tested with a realistic one-dimensional resistivity model of the Earth in the region of study (northern Spain CO2 sequestration test site). We show that a small number of well distributed observations have the potential to resolve the target. This simple test also points out the importance of a well chosen objective function. Finally, in the context of CO2 sequestration that motivates this study, we might be interested in maximizing the information we get about the reservoir layer. In that case, we show how the combination of two different objective functions considerably improve its resolution.

  4. ITER [International Thermonuclear Experimental Reactor] reactor building design study

    International Nuclear Information System (INIS)

    Thomson, S.L.; Blevins, J.D.; Delisle, M.W.

    1989-01-01

    The International Thermonuclear Experimental Reactor (ITER) is at the midpoint of a two-year conceptual design. The ITER reactor building is a reinforced concrete structure that houses the tokamak and associated equipment and systems and forms a barrier between the tokamak and the external environment. It provides radiation shielding and controls the release of radioactive materials to the environment during both routine operations and accidents. The building protects the tokamak from external events, such as earthquakes or aircraft strikes. The reactor building requirements have been developed from the component designs and the preliminary safety analysis. The equipment requirements, tritium confinement, and biological shielding have been studied. The building design in progress requires continuous iteraction with the component and system designs and with the safety analysis. 8 figs

  5. Design and experimental characterization of an EM pump

    International Nuclear Information System (INIS)

    Kim, Hee Reyoung; Hong, Sang Hee

    1999-01-01

    Generally, an EM (electromagnetic) pump is been employed to circulate electrically conducting liquids by using the Lorentz force. Especially, at the liquid metal reactor (LMR), which uses liquid sodium with high electrical conductivity as a coolant, an EM pump is needed due to its advantages over a mechanical pump, such as no rotating parts, no noise, and simplicity. In this research, an EM pump of a pilot annular linear induction type with a flow rate of 200 l/min was designed by using the electrical equivalent-circuit method. The pump was designed and manufactured by considering material and environmental (high temperature and liquid sodium) requirements. The pump performance was experimentally characterized based on input currents, voltage, power, and frequency. Also, the theoretical prediction was compared with the experimental result

  6. Fast Bayesian optimal experimental design and its applications

    KAUST Repository

    Long, Quan

    2015-01-07

    We summarize our Laplace method and multilevel method of accelerating the computation of the expected information gain in a Bayesian Optimal Experimental Design (OED). Laplace method is a widely-used method to approximate an integration in statistics. We analyze this method in the context of optimal Bayesian experimental design and extend this method from the classical scenario, where a single dominant mode of the parameters can be completely-determined by the experiment, to the scenarios where a non-informative parametric manifold exists. We show that by carrying out this approximation the estimation of the expected Kullback-Leibler divergence can be significantly accelerated. While Laplace method requires a concentration of measure, multi-level Monte Carlo method can be used to tackle the problem when there is a lack of measure concentration. We show some initial results on this approach. The developed methodologies have been applied to various sensor deployment problems, e.g., impedance tomography and seismic source inversion.

  7. Design of JT-60SA magnets and associated experimental validations

    International Nuclear Information System (INIS)

    Zani, L.; Barabaschi, P.; Peyrot, M.; Meunier, L.; Tomarchio, V.; Duglue, D.; Decool, P.; Torre, A.; Marechal, J.L.; Della Corte, A.; Di Zenobio, A.; Muzzi, L.; Cucchiaro, A.; Turtu, S.; Ishida, S.; Yoshida, K.; Tsuchiya, K.; Kizu, K.; Murakami, H.

    2011-01-01

    In the framework of the JT-60SA project, aiming at upgrading the present JT-60U tokamak toward a fully superconducting configuration, the detailed design phase led to adopt for the three main magnet systems a brand new design. Europe (EU) is expected to provide to Japan (JA) the totality of the toroidal field (TF) magnet system, while JA will provide both Equilibrium field (EF) and Central Solenoid (CS) systems. All magnet designs were optimized trough the past years and entered in parallel into extensive experimentally-based phases of concept validation, which came to maturation in the years 2009 and 2010. For this, all magnet systems were investigated by mean of dedicated samples, e.g. conductor and joint samples designed, manufactured and tested at full scale in ad hoc facilities either in EU or in JA. The present paper, after an overall description of magnet systems layouts, presents in a general approach the different experimental campaigns dedicated to qualification design and manufacture processes of either coils, conductors and electrical joints. The main results with the associated analyses are shown and the main conclusions presented, especially regarding their contribution to consolidate the triggering of magnet mass production. The status of respective manufacturing stages in EU and in JA are also evoked. (authors)

  8. Study of Formulation Variables Influencing Polymeric Microparticles by Experimental Design

    Directory of Open Access Journals (Sweden)

    Jitendra B. Naik

    2014-04-01

    Full Text Available The objective of this study was to prepare diclofenac sodium loaded microparticles by single emulsion [oil-in-water (o/w] solvent evaporation method. The 22 experimental design methodology was used to evaluate the effect of two formulation variables on microspheres properties using the Design-Expert® software and evaluated for their particle size, morphology, and encapsulation efficiency and in vitro drug release. The graphical and mathematical analysis of the design showed that the independent variables were a significant effect on the encapsulation efficiency and drug release of microparticles. The low magnitudes of error and significant values of R2 prove the high prognostic ability of the design. The microspheres showed high encapsulation efficiency with an increase in the amount of polymer and decrease in the amount of PVA in the formulation. The particles were found to be spherical with smooth surface. Prolonged drug release and enhancement of encapsulation efficiency of polymeric microparticles can be successfully obtained with an application of experimental design technique.

  9. Design, construction and testing of a radon experimental chamber

    International Nuclear Information System (INIS)

    Chavez B, A.; Balcazar G, M.

    1991-10-01

    To carry out studies on the radon behavior under controlled and stable conditions it was designed and constructed a system that consists of two parts: a container of mineral rich in Uranium and an experimentation chamber with radon united one to the other one by a step valve. The container of uranium mineral approximately contains 800 gr of uranium with a law of 0.28%; the radon gas emanated by the mineral is contained tightly by the container. When the valve opens up the radon gas it spreads to the radon experimental chamber; this contains 3 accesses that allow to install different types of detectors. The versatility of the system is exemplified with two experiments: 1. With the radon experimental chamber and an associated spectroscopic system, the radon and two of its decay products are identified. 2. The design of the system allows to couple the mineral container to other experimental geometries to demonstrate this fact it was coupled and proved a new automatic exchanger system of passive detectors of radon. The results of the new automatic exchanger system when it leave to flow the radon freely among the container and the automatic exchanger through a plastic membrane of 15 m. are shown. (Author)

  10. EXPERIMENTAL APPROACHES IN CLOTHING DESIGN SINCE 20th CENTURY

    Directory of Open Access Journals (Sweden)

    Irem Sabanuc Gonul

    2016-12-01

    Full Text Available There has always been a search for the new/different in the history of clothing design. Yet, from 20th century onwards changes in these search reached to a considerable level with the advent of artistic expression beside functionality. A modern understanding that broke the routine predominated within which the ‘new’ is questioned. The effects that were considered as innovation before 20th Century began to metamorphose. As a result of artistic movements and technological progress, experimental movements of the 20th century affected the 21st century in the sense that the experimentalism in clothing design became a style of expression rather than a search. These developments brought a new dimension into the relation of art and and clothing design. The paper reflects on the historical process of experimental approach, volumetric and sculptural effects and search for innovative materials with prominent examples. Current work includes analysis on the emergence of clothing ‘independent of human body’ as an object of art as well as inquiries on current situation.

  11. Experimental designs for a benign paroxysmal positional vertigo model.

    Science.gov (United States)

    Campos-Barreiro, Santiago; López-Fidalgo, Jesús

    2013-03-19

    The pathology of the Benign Paroxysmal Positional Vertigo (BPPV) is detected by a clinician through maneuvers consisting of a series of consecutive head turns that trigger the symptoms of vertigo in patient. A statistical model based on a new maneuver has been developed in order to calculate the volume of endolymph displaced after the maneuver. A simplification of the Navier-Stokes problem from the fluids theory has been used to construct the model. In addition, the same cubic splines that are commonly used in kinematic control of robots were used to obtain an appropriate description of the different maneuvers. Then experimental designs were computed to obtain an optimal estimate of the model. D-optimal and c-optimal designs of experiments have been calculated. These experiments consist of a series of specific head turns of duration Δt and angle α that should be performed by the clinician on the patient. The experimental designs obtained indicate the duration and angle of the maneuver to be performed as well as the corresponding proportion of replicates. Thus, in the D-optimal design for 100 experiments, the maneuver consisting of a positive 30° pitch from the upright position, followed by a positive 30° roll, both with a duration of one and a half seconds is repeated 47 times. Then the maneuver with 60° /6° pitch/roll during half a second is repeated 16 times and the maneuver 90° /90° pitch/roll during half a second is repeated 37 times. Other designs with significant differences are computed and compared. A biomechanical model was derived to provide a quantitative basis for the detection of BPPV. The robustness study for the D-optimal design, with respect to the choice of the nominal values of the parameters, shows high efficiencies for small variations and provides a guide to the researcher. Furthermore, c-optimal designs give valuable assistance to check how efficient the D-optimal design is for the estimation of each of the parameters. The experimental

  12. Bayesian Optimal Experimental Design Using Multilevel Monte Carlo

    KAUST Repository

    Ben Issaid, Chaouki

    2015-01-07

    Experimental design is very important since experiments are often resource-exhaustive and time-consuming. We carry out experimental design in the Bayesian framework. To measure the amount of information, which can be extracted from the data in an experiment, we use the expected information gain as the utility function, which specifically is the expected logarithmic ratio between the posterior and prior distributions. Optimizing this utility function enables us to design experiments that yield the most informative data for our purpose. One of the major difficulties in evaluating the expected information gain is that the integral is nested and can be high dimensional. We propose using Multilevel Monte Carlo techniques to accelerate the computation of the nested high dimensional integral. The advantages are twofold. First, the Multilevel Monte Carlo can significantly reduce the cost of the nested integral for a given tolerance, by using an optimal sample distribution among different sample averages of the inner integrals. Second, the Multilevel Monte Carlo method imposes less assumptions, such as the concentration of measures, required by Laplace method. We test our Multilevel Monte Carlo technique using a numerical example on the design of sensor deployment for a Darcy flow problem governed by one dimensional Laplace equation. We also compare the performance of the Multilevel Monte Carlo, Laplace approximation and direct double loop Monte Carlo.

  13. Limit state design based on experimental methods for high pressure subsea pipeline design

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, Chris [Stress Engineering Services Inc., Houston, TX, (United States)

    2010-07-01

    Pipelines used for subsea transportation need to resist high pressure. This paper investigated the benefits associated with establishing a limit state design pressure for high pressure subsea pipelines based on experimental methods. A testing program has carried out to evaluate the design pressure for an 18-inch x 0.75-inch grade X65 gas pipeline using the methodology of API RP 1111. Two full-scale burst tests were conducted. A review of the design codes is also presented to assess the validity of the testing results. Using the design option of API RP 1111, the resulting design pressure was 4,448 psi. Using ASME B31.8, the design pressure would have been 3,900 psi. These results showed a net increase in the design pressure of 14 %. It is found that using a limit state design process based on API RP 1111 offered economic benefits derived from more rigorous material qualification.

  14. Conceptual design of neutron diagnostic systems for fusion experimental reactor

    International Nuclear Information System (INIS)

    Iguchi, T.; Kaneko, J.; Nakazawa, M.

    1994-01-01

    Neutron measurement in fusion experimental reactors is very important for burning plasma diagnostics and control, monitoring of irradiation effects on device components, neutron source characterization for in-situ engineering tests, etc. A conceptual design of neutron diagnostic systems for an ITER-like fusion experimental reactor has been made, which consists of a neutron yield monitor, a neutron emission profile monitor and a 14-MeV spectrometer. Each of them is based on a unique idea to meet the required performances for full power conditions assumed at ITER operation. Micro-fission chambers of 235 U (and 238 U) placed at several poloidal angles near the first wall are adopted as a promising neutron yield monitor. A collimated long counter system using a 235 U fission chamber and graphite neutron moderators is also proposed to improve the calibration accuracy of absolute neutron yield determination

  15. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2012-10-01

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This project will directly support the technical goals specified in DEFOA- 0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop and implement novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; perform material characterizations and oxidation/corrosion tests; and demonstrate our new thermal barrier coating (TBC) systems experimentally under integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed Durability Test Rig.

  16. Stimulated Brillouin scattering materials, experimental design and applications: A review

    Science.gov (United States)

    Bai, Zhenxu; Yuan, Hang; Liu, Zhaohong; Xu, Pengbai; Gao, Qilin; Williams, Robert J.; Kitzler, Ondrej; Mildren, Richard P.; Wang, Yulei; Lu, Zhiwei

    2018-01-01

    Stimulated Brillouin scattering (SBS), as one type of third-order nonlinear optics effect, is extensively exploited and rapidly developed in the field of lasers and optoelectronics. A large number of theoretical and experimental studies on SBS have been carried out in the past decades. Especially, the exploration of new SBS materials and new types of SBS modulation methods have been engaged simultaneously, as the properties of different materials have great influence on the SBS performance such as generation threshold, Brillouin amplification efficiency, frequency shift, breakdown threshold, etc. This article provides a comprehensive review of the characteristics of different types of SBS materials, SBS applications, experimental design methods, as well as the parameter optimization method, which is expected to provide reference and guidance to SBS related experiments.

  17. Spent Fuel Transportation Package Performance Study - Experimental Design Challenges

    International Nuclear Information System (INIS)

    Snyder, A. M.; Murphy, A. J.; Sprung, J. L.; Ammerman, D. J.; Lopez, C.

    2003-01-01

    Numerous studies of spent nuclear fuel transportation accident risks have been performed since the late seventies that considered shipping container design and performance. Based in part on these studies, NRC has concluded that the level of protection provided by spent nuclear fuel transportation package designs under accident conditions is adequate. [1] Furthermore, actual spent nuclear fuel transport experience showcase a safety record that is exceptional and unparalleled when compared to other hazardous materials transportation shipments. There has never been a known or suspected release of the radioactive contents from an NRC-certified spent nuclear fuel cask as a result of a transportation accident. In 1999 the United States Nuclear Regulatory Commission (NRC) initiated a study, the Package Performance Study, to demonstrate the performance of spent fuel and spent fuel packages during severe transportation accidents. NRC is not studying or testing its current regulations, a s the rigorous regulatory accident conditions specified in 10 CFR Part 71 are adequate to ensure safe packaging and use. As part of this study, NRC currently plans on using detailed modeling followed by experimental testing to increase public confidence in the safety of spent nuclear fuel shipments. One of the aspects of this confirmatory research study is the commitment to solicit and consider public comment during the scoping phase and experimental design planning phase of this research

  18. Acting like a physicist: Student approach study to experimental design

    Directory of Open Access Journals (Sweden)

    Anna Karelina

    2007-10-01

    Full Text Available National studies of science education have unanimously concluded that preparing our students for the demands of the 21st century workplace is one of the major goals. This paper describes a study of student activities in introductory college physics labs, which were designed to help students acquire abilities that are valuable in the workplace. In these labs [called Investigative Science Learning Environment (ISLE labs], students design their own experiments. Our previous studies have shown that students in these labs acquire scientific abilities such as the ability to design an experiment to solve a problem, the ability to collect and analyze data, the ability to evaluate assumptions and uncertainties, and the ability to communicate. These studies mostly concentrated on analyzing students’ writing, evaluated by specially designed scientific ability rubrics. Recently, we started to study whether the ISLE labs make students not only write like scientists but also engage in discussions and act like scientists while doing the labs. For example, do students plan an experiment, validate assumptions, evaluate results, and revise the experiment if necessary? A brief report of some of our findings that came from monitoring students’ activity during ISLE and nondesign labs was presented in the Physics Education Research Conference Proceedings. We found differences in student behavior and discussions that indicated that ISLE labs do in fact encourage a scientistlike approach to experimental design and promote high-quality discussions. This paper presents a full description of the study.

  19. Conceptual design study of fusion experimental reactor (FER)

    International Nuclear Information System (INIS)

    1986-11-01

    Since 1980 the design study has been conducted at JAERI for the Fusion Experimental Reactor (FER) which has been proposed to be the next machine to JT-60 in the Japanese long term program of fusion reactor development. During two years from 1984 to 1985 FER concept was reviewed and redesigned. This report is the summary of the results obtained in the review and redesign activities in 1984 and 85. In the first year FER concept was discussed again and its frame work was reestablished. According to the new frame work the major reactor components of FER were designed. In the second year the whole plant system design including plant layout plan was conducted as well as the more detailed design analysis of the reactor conponents. The newly established frame for FER design is as follows: 1) Plasma : Self-ignition. 2) Operation scenario : Quasi-steady state operation with long burn pulse. 3) Neutron fluence on the first wall : 0.3 MWY/M 2 . 4) Blanket : Non-tritium breeding blanket with test modules for breeding blanket development. 5) Magnets : Superconducting Magnets. (author)

  20. Development of prilling process for biodegradable microspheres through experimental designs.

    Science.gov (United States)

    Fabien, Violet; Minh-Quan, Le; Michelle, Sergent; Guillaume, Bastiat; Van-Thanh, Tran; Marie-Claire, Venier-Julienne

    2016-02-10

    The prilling process proposes a microparticle formulation easily transferable to the pharmaceutical production, leading to monodispersed and highly controllable microspheres. PLGA microspheres were used for carrying an encapsulated protein and adhered stem cells on its surface, proposing a tool for regeneration therapy against injured tissue. This work focused on the development of the production of PLGA microspheres by the prilling process without toxic solvent. The required production quality needed a complete optimization of the process. Seventeen parameters were studied through experimental designs and led to an acceptable production. The key parameters and mechanisms of formation were highlighted. Copyright © 2015. Published by Elsevier B.V.

  1. Considerations in Writing About Single-Case Experimental Design Studies.

    Science.gov (United States)

    Skolasky, Richard L

    2016-12-01

    Single-case experimental design (SCED) studies are particularly useful for examining the processes and outcomes of psychological and behavioral studies. Accurate reporting of SCED studies is critical in explaining the study to the reader and allowing replication. This paper outlines important elements that authors should cover when reporting the results of a SCED study. Authors should provide details on the participant, independent and dependent variables under examination, materials and procedures, and data analysis. Particular emphasis should be placed on justifying the assumptions made and explaining how violations of these assumptions may alter the results of the SCED study.

  2. The 'FINTOR 1' design. A minimum size Tokamak Experimental Reactor

    International Nuclear Information System (INIS)

    Bertolini, E.

    1978-01-01

    The work carried on by the FINTOR (Frascati, Ispra, Napoli, Tokamak Reactor) group has now reached a stage where the effects of the main physics and engineering constraints, for a minimum size Tokamak Experimental Reactor have been clearly identified. This phase, now completed, has allowed to produce a self-consistent design of each basic component of the reactor, FINTOR 1, and to identify the more relevant interface problems toward a further optimisation of the reactor dimensions and characteristics to be performed in the future (FINTOR 2)

  3. Superconducting coil design for a tokamak experimental power reactor

    International Nuclear Information System (INIS)

    Turner, L.R.; Wang, S.T.; Smelser, P.

    1977-01-01

    Superconducting toroidal field (TF) and polodial-field (PF) coils have been designed for the proposed Argonne National Laboratory experimental power reactor (EPR). Features of the design include: (1) Peak field of 8 T at 4.2 K or 10 T at 3.0 K. (2) Constant-tension shape for the TF coils, corrected for the finite number (16) of coils. (3) Analysis of errors in coil alignment. (4) Comparison of safety aspects of series-connected and parallel-connected coils. (5) A 60 kA sheet conductor of NbTi with copper stabilizer and stainless steel for support. (6) Superconducting PF coils outside the TF coils. (7) The TF coils shielded from pulsed fields by high-purity aluminum

  4. Tritium system design studies of fusion experimental breeder

    International Nuclear Information System (INIS)

    Deng Baiquan; Huang Jinhua

    2003-01-01

    A summary of the tritium system design studies for the engineering outline design of a fusion experimental breeder (FEB-E) is presented. This paper is divided into three sections. In first section, the geometry, loading features and tritium concentrations in liquid lithium of tritium breeding zones of blanket are described. The tritium flow chart corresponding to the tritium fuel cycle system has been constructed, and the inventories in ten subsystems are calculated using SWITRIM code in section 2. Results show that the necessary initial tritium storage to start up FEB-E with fusion power of 143 MW is about 319 g. In final section, the tritium leakage issues under different operation circumstances have been analyzed. It was found that the potential danger of tritium leakage could be resulted from the exhausted gas of the diverter system. It is important to elevate the tritium burnup fraction and reduce the tritium throughput. (authors)

  5. Parameters optimization for enzymatic assays using experimental design

    Directory of Open Access Journals (Sweden)

    J. F. M. Burkert

    2006-06-01

    Full Text Available The conditions for maximization enzymatic activity were determined using experimental design and inulinase from Kluyveromyces marxianus ATCC 16045. The effects of substrate concentration (sucrose and inulin, pH and temperature on inulinase activity were verified using four factorial design and surface response analysis. Using sucrose as substrate. It has bean shown that the effects sucrose on enzymatic activity is not statistically significant and the best condition for the highest activity (110 U/mL was achieved with temperature between 60°C and 68°C and pH between 4.5 and 5.0. Using inulin as substrate it was verified that temperature is the only variable statistically significant and the maximum activity was 7.3 U/mL at temperature between 50°C and 51°C.

  6. Conceptual design study of fusion experimental reactor (FY86 FER)

    International Nuclear Information System (INIS)

    Seki, Yasushi; Iida, Hiromasa; Honda, Tsutomu.

    1987-08-01

    This report describes the study on safety for FER(Fusion Experimental Reactor) which has been designed as a next step machine to the JT-60. Though the final purpose of this study is to have an image of design base accident, maximum credible accident and to assess their risk or probability, etc., as FER plant system, the emphasis of this years study is placed on fuel-gas circulation system where the tritium inventory is maximum. This report consists of two chapters. The first chapter of this report summaries the FER system and describes FMEA(Failure Mode and Effect Analysis) and related accident progression sequence for FER plant system as a whole. The second chapter of this report is focused on fuel-gas circulation system including the purification, isotope separation system and storage system. Here, probability of risk is assessed by the probabilistic risk analysis (PRA) procedure based on FMEA, ETA and FTA. (author)

  7. Design study of toroidal magnets for tokamak experimental power reactors

    International Nuclear Information System (INIS)

    Stekly, Z.J.J.; Lucas, E.J.

    1976-12-01

    This report contains the results of a six-month study of superconducting toroidal field coils for a Tokamak Experimental Power Reactor to be built in the late 1980s. The designs are for 8 T and 12 T maximum magnetic field at the superconducting winding. At each field level two main concepts were generated; one in which each of the 16 coils comprising the system has an individual vacuum vessel and the other in which all the coils are contained in a single vacuum vessel. The coils have a D shape and have openings of 11.25 m x 7.5 m for the 8 T coils and 10.2 m x 6.8 m for the 12 T coils. All the designs utilize rectangular cabled conductor made from copper stabilized Niobium Titanium composite which operates at 4.2 K for the 8 T design and at 2.5 K for the 12 T design. Manufacturing procedures, processes and schedule estimates are also discussed

  8. Design of Experimental Suspended Footbridge with Deck Made of UHPC

    Directory of Open Access Journals (Sweden)

    Blank Marek

    2016-01-01

    Full Text Available This paper deals with the static and dynamic design of experimental footbridge for pedestrians and cyclists in the municipality Lužec nad Vltavou in Czech Republic, Europe. This work aims to familiarize the reader with calculations carried out and the results obtained, describing the static and dynamic properties of proposed footbridge. The construction of footbridge is designed as a suspended structure with prestressed bridge deck consisting of prefabricated UHPC panels and reversed “V” shaped steel pylon with height of approximately 40 meters. The deck is anchored using 24 steel hangers in one row in a steel pylon - 17 ropes in the main span and 7 cables on the other side. Range of the main span is 99.18 meters and the secondary span is 31.9 m. Deck width is 4.5 meters with 3.0 meters passing space. The bridge is designed for the possibility of passage of vehicles weighting up to 3.5 tons. Deck panels are made of UHPC with reinforcement. At the edge of the bridge on the side of the shorter span the bridge deck is firmly connected with abutment and on the other deck it is stored using a pair of sliding bearings. The utilization of the excellent properties of UHPC allows to design a very thin and lightweight construction of the deck, which could not be achieved with the use of normal concrete.

  9. A fundamental experimental approach for optimal design of speed bumps.

    Science.gov (United States)

    Lav, A Hakan; Bilgin, Ertugrul; Lav, A Hilmi

    2017-06-02

    Speed bumps and humps are utilized as means of calming traffic and controlling vehicular speed. Needless to say, bumps and humps of large dimensions in length and width force drivers to significantly reduce their driving speeds so as to avoid significant vehicle vertical acceleration. It is thus that this experimental study was conducted with the aim of determining a speed bump design that performs optimally when leading drivers to reduce the speed of their vehicles to safe levels. The first step of the investigation starts off by considering the following question: "What is the optimal design of a speed bump that will - at the same time - reduce the velocity of an incoming vehicle significantly and to a speed that resulting vertical acceleration does not jeopardize road safety? The experiment has been designed to study the dependent variables and collect data in order to propose an optimal design for a speed bump. To achieve this, a scaled model of 1:6 to real life was created to simulate the interaction between a car wheel and a speed bump. During the course of the experiment, a wheel was accelerated down an inclined plane onto a horizontal plane of motion where it was allowed to collide with a speed bump. The speed of the wheel and the vertical acceleration at the speed bump were captured by means of a Vernier Motion Detector. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Designing Awe in Virtual Reality: An Experimental Study

    Directory of Open Access Journals (Sweden)

    Alice Chirico

    2018-01-01

    Full Text Available Awe is a little-studied emotion with a great transformative potential. Therefore, the interest toward the study of awe’s underlying mechanisms has been increased. Specifically, researchers have been interested in how to reproduce intense feelings of awe within laboratory conditions. It has been proposed that the use of virtual reality (VR could be an effective way to induce awe in controlled experimental settings, thanks to its ability of providing participants with a sense of “presence,” that is, the subjective feeling of being displaced in another physical or imaginary place. However, the potential of VR as awe-inducing medium has not been fully tested yet. In the present study, we provided an evidence-based design and a validation of four immersive virtual environments (VEs involving 36 participants in a within-subject design. Of these, three VEs were designed to induce awe, whereas the fourth VE was targeted as an emotionally neutral stimulus. Participants self-reported the extent to which they felt awe, general affect and sense of presence related to each environment. As expected, results showed that awe-VEs could induce significantly higher levels of awe and presence as compared to the neutral VE. Furthermore, these VEs induced significantly more positive than negative affect. These findings supported the potential of immersive VR for inducing awe and provide useful indications for the design of awe-inspiring virtual environments.

  11. Skin microbiome surveys are strongly influenced by experimental design

    Science.gov (United States)

    Meisel, Jacquelyn S.; Hannigan, Geoffrey D.; Tyldsley, Amanda S.; SanMiguel, Adam J.; Hodkinson, Brendan P.; Zheng, Qi; Grice, Elizabeth A.

    2016-01-01

    Culture-independent studies to characterize skin microbiota are increasingly common, due in part to affordable and accessible sequencing and analysis platforms. Compared to culture-based techniques, DNA sequencing of the bacterial 16S ribosomal RNA (rRNA) gene or whole metagenome shotgun (WMS) sequencing provide more precise microbial community characterizations. Most widely used protocols were developed to characterize microbiota of other habitats (i.e. gastrointestinal), and have not been systematically compared for their utility in skin microbiome surveys. Here we establish a resource for the cutaneous research community to guide experimental design in characterizing skin microbiota. We compare two widely sequenced regions of the 16S rRNA gene to WMS sequencing for recapitulating skin microbiome community composition, diversity, and genetic functional enrichment. We show that WMS sequencing most accurately recapitulates microbial communities, but sequencing of hypervariable regions 1-3 of the 16S rRNA gene provides highly similar results. Sequencing of hypervariable region 4 poorly captures skin commensal microbiota, especially Propionibacterium. WMS sequencing, which is resource- and cost-intensive, provides evidence of a community’s functional potential; however, metagenome predictions based on 16S rRNA sequence tags closely approximate WMS genetic functional profiles. This work highlights the importance of experimental design for downstream results in skin microbiome surveys. PMID:26829039

  12. Fast Bayesian optimal experimental design for seismic source inversion

    KAUST Repository

    Long, Quan

    2015-07-01

    We develop a fast method for optimally designing experiments in the context of statistical seismic source inversion. In particular, we efficiently compute the optimal number and locations of the receivers or seismographs. The seismic source is modeled by a point moment tensor multiplied by a time-dependent function. The parameters include the source location, moment tensor components, and start time and frequency in the time function. The forward problem is modeled by elastodynamic wave equations. We show that the Hessian of the cost functional, which is usually defined as the square of the weighted L2 norm of the difference between the experimental data and the simulated data, is proportional to the measurement time and the number of receivers. Consequently, the posterior distribution of the parameters, in a Bayesian setting, concentrates around the "true" parameters, and we can employ Laplace approximation and speed up the estimation of the expected Kullback-Leibler divergence (expected information gain), the optimality criterion in the experimental design procedure. Since the source parameters span several magnitudes, we use a scaling matrix for efficient control of the condition number of the original Hessian matrix. We use a second-order accurate finite difference method to compute the Hessian matrix and either sparse quadrature or Monte Carlo sampling to carry out numerical integration. We demonstrate the efficiency, accuracy, and applicability of our method on a two-dimensional seismic source inversion problem. © 2015 Elsevier B.V.

  13. Fast Bayesian Optimal Experimental Design for Seismic Source Inversion

    KAUST Repository

    Long, Quan

    2016-01-06

    We develop a fast method for optimally designing experiments [1] in the context of statistical seismic source inversion [2]. In particular, we efficiently compute the optimal number and locations of the receivers or seismographs. The seismic source is modeled by a point moment tensor multiplied by a time-dependent function. The parameters include the source location, moment tensor components, and start time and frequency in the time function. The forward problem is modeled by the elastic wave equations. We show that the Hessian of the cost functional, which is usually defined as the square of the weighted L2 norm of the difference between the experimental data and the simulated data, is proportional to the measurement time and the number of receivers. Consequently, the posterior distribution of the parameters, in a Bayesian setting, concentrates around the true parameters, and we can employ Laplace approximation and speed up the estimation of the expected Kullback-Leibler divergence (expected information gain), the optimality criterion in the experimental design procedure. Since the source parameters span several magnitudes, we use a scaling matrix for efficient control of the condition number of the original Hessian matrix. We use a second-order accurate finite difference method to compute the Hessian matrix and either sparse quadrature or Monte Carlo sampling to carry out numerical integration. We demonstrate the efficiency, accuracy, and applicability of our method on a two-dimensional seismic source inversion problem.

  14. Experimental Vertical Stability Studies for ITER Performance and Design Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Humphreys, D A; Casper, T A; Eidietis, N; Ferrera, M; Gates, D A; Hutchinson, I H; Jackson, G L; Kolemen, E; Leuer, J A; Lister, J; LoDestro, L L; Meyer, W H; Pearlstein, L D; Sartori, F; Walker, M L; Welander, A S; Wolfe, S M

    2008-10-13

    Operating experimental devices have provided key inputs to the design process for ITER axisymmetric control. In particular, experiments have quantified controllability and robustness requirements in the presence of realistic noise and disturbance environments, which are difficult or impossible to characterize with modeling and simulation alone. This kind of information is particularly critical for ITER vertical control, which poses some of the highest demands on poloidal field system performance, since the consequences of loss of vertical control can be very severe. The present work describes results of multi-machine studies performed under a joint ITPA experiment on fundamental vertical control performance and controllability limits. We present experimental results from Alcator C-Mod, DIII-D, NSTX, TCV, and JET, along with analysis of these data to provide vertical control performance guidance to ITER. Useful metrics to quantify this control performance include the stability margin and maximum controllable vertical displacement. Theoretical analysis of the maximum controllable vertical displacement suggests effective approaches to improving performance in terms of this metric, with implications for ITER design modifications. Typical levels of noise in the vertical position measurement which can challenge the vertical control loop are assessed and analyzed.

  15. Design preferences and cognitive styles: experimentation by automated website synthesis.

    Science.gov (United States)

    Leung, Siu-Wai; Lee, John; Johnson, Chris; Robertson, David

    2012-06-29

    This article aims to demonstrate computational synthesis of Web-based experiments in undertaking experimentation on relationships among the participants' design preference, rationale, and cognitive test performance. The exemplified experiments were computationally synthesised, including the websites as materials, experiment protocols as methods, and cognitive tests as protocol modules. This work also exemplifies the use of a website synthesiser as an essential instrument enabling the participants to explore different possible designs, which were generated on the fly, before selection of preferred designs. The participants were given interactive tree and table generators so that they could explore some different ways of presenting causality information in tables and trees as the visualisation formats. The participants gave their preference ratings for the available designs, as well as their rationale (criteria) for their design decisions. The participants were also asked to take four cognitive tests, which focus on the aspects of visualisation and analogy-making. The relationships among preference ratings, rationale, and the results of cognitive tests were analysed by conservative non-parametric statistics including Wilcoxon test, Krustal-Wallis test, and Kendall correlation. In the test, 41 of the total 64 participants preferred graphical (tree-form) to tabular presentation. Despite the popular preference for graphical presentation, the given tabular presentation was generally rated to be easier than graphical presentation to interpret, especially by those who were scored lower in the visualization and analogy-making tests. This piece of evidence helps generate a hypothesis that design preferences are related to specific cognitive abilities. Without the use of computational synthesis, the experiment setup and scientific results would be impractical to obtain.

  16. Oak Ridge Tokamak experimental power reactor study reference design

    International Nuclear Information System (INIS)

    Roberts, M.; Bettis, E.S.

    1975-11-01

    A Tokamak EPR Reference Design is presented as a basis for further design study leading to a Conceptual Design. The set of basic plasma parameters selected--minor radius of 2.25 m, major radius of 6.75 m, magnetic field on axis of 4.8 T and plasma current of 7.2 MA--should produce a reactor-grade plasma with a significant neutron flux, even with the great uncertainty in plasma physics scaling from present experience to large sizes. Neutronics and heat transfer calculations coupled with mechanical design and materials considerations were used to develop a blanket and shield capable of operating at high temperature, protecting the surrounding coils, being maintained remotely and, in a few experimental modules, breeding tritium. Nb 3 Sn and NbTi superconductors are used in the toroidal field coil design. The coil system was developed for a maximum field of 11 T at the winding (to give a field on axis of 4.8 T), and combines multifilamentary superconducting cable with forced flow of supercritical helium enclosed in a steel conduit. The structural system uses a stainless steel center bucking ring and intercoil box beam bracing to provide rigid support for coils against the centering force, overturning moments from poloidal fields and faults, other external forces, and thermal stresses. The poloidal magnetics system is specially designed both to reduce the total volt-second energy requirements and to reduce the magnitude of the rate of field change at the toroidal field coils. The rate of field change imposed upon the toroidal field coils is reduced by at least a factor of 3.3 compared to that due to the plasma alone. Tritium processing, tritium containment and vacuum systems employ double containment and atmospheric cleanup to minimize releases. The document also contains discussions of systems integration and assembly, key research and development needs, and schedule considerations

  17. Bayesian optimal experimental design for priors of compact support

    KAUST Repository

    Long, Quan

    2016-01-08

    In this study, we optimize the experimental setup computationally by optimal experimental design (OED) in a Bayesian framework. We approximate the posterior probability density functions (pdf) using truncated Gaussian distributions in order to account for the bounded domain of the uniform prior pdf of the parameters. The underlying Gaussian distribution is obtained in the spirit of the Laplace method, more precisely, the mode is chosen as the maximum a posteriori (MAP) estimate, and the covariance is chosen as the negative inverse of the Hessian of the misfit function at the MAP estimate. The model related entities are obtained from a polynomial surrogate. The optimality, quantified by the information gain measures, can be estimated efficiently by a rejection sampling algorithm against the underlying Gaussian probability distribution, rather than against the true posterior. This approach offers a significant error reduction when the magnitude of the invariants of the posterior covariance are comparable to the size of the bounded domain of the prior. We demonstrate the accuracy and superior computational efficiency of our method for shock-tube experiments aiming to measure the model parameters of a key reaction which is part of the complex kinetic network describing the hydrocarbon oxidation. In the experiments, the initial temperature and fuel concentration are optimized with respect to the expected information gain in the estimation of the parameters of the target reaction rate. We show that the expected information gain surface can change its shape dramatically according to the level of noise introduced into the synthetic data. The information that can be extracted from the data saturates as a logarithmic function of the number of experiments, and few experiments are needed when they are conducted at the optimal experimental design conditions.

  18. Optimal experimental designs for fMRI via circulant biased weighing designs

    OpenAIRE

    Cheng, Ching-Shui; Kao, Ming-Hung

    2015-01-01

    Functional magnetic resonance imaging (fMRI) technology is popularly used in many fields for studying how the brain reacts to mental stimuli. The identification of optimal fMRI experimental designs is crucial for rendering precise statistical inference on brain functions, but research on this topic is very lacking. We develop a general theory to guide the selection of fMRI designs for estimating a hemodynamic response function (HRF) that models the effect over time of the mental stimulus, and...

  19. Experimental study of elementary collection efficiency of aerosols by spray: Design of the experimental device

    Energy Technology Data Exchange (ETDEWEB)

    Ducret, D.; Vendel, J.; Garrec. S.L.

    1995-02-01

    The safety of a nuclear power plant containment building, in which pressure and temperature could increase because of a overheating reactor accident, can be achieved by spraying water drops. The spray reduces the pressure and the temperature levels by condensation of steam on cold water drops. The more stringent thermodynamic conditions are a pressure of 5.10{sup 5} Pa (due to steam emission) and a temperature of 413 K. Moreover its energy dissipation function, the spray leads to the washout of fission product particles emitted in the reactor building atmosphere. The present study includes a large program devoted to the evaluation of realistic washout rates. The aim of this work is to develop experiments in order to determine the collection efficiency of aerosols by a single drop. To do this, the experimental device has to be designed with fundamental criteria:-Thermodynamic conditions have to be representative of post-accident atmosphere. Thermodynamic equilibrium has to be attained between the water drops and the gaseous phase. Thermophoretic, diffusiophoretic and mechanical effects have to be studied independently. Operating conditions have to be homogenous and constant during each experiment. This paper presents the design of the experimental device. In practice, the consequences on the design of each of the criteria given previously and the necessity of being representative of the real conditions will be described.

  20. Design, tolerancing, and experimental characterization of dynamic freeform optical systems

    Science.gov (United States)

    Shultz, Jason Allen

    Although freeform concepts have been considered for many decades, new fabrication capabilities have enabled new classes of optical components and sparked greatly increased interest in freeform optics. Generally defined as surfaces without rotational symmetry, freeform optics enable complex phase variations due to their asymmetry. One approach for freeform optics utilizes multiple freeform surfaces in close proximity. Light transmitted through these surfaces results in a composite wavefront, which is then dynamically changed through controlled relative motions of the freeform surfaces, thereby dynamically changing the overall optical function of the system. These 'dynamic freeform optics' offer advantages such as design miniaturization, decreased manufacturing costs, and optical design flexibility. Examples include the varifocal Alvarez lens and a variable diameter Gaussian to flat-top beam shaper. In these cases the output function is varied through relative lateral shifts. The analytical design procedures for these examples have been well documented in previous work. However, previous cases possess inherent design constraints. For example, the classic Alvarez lens has no optical power when the lateral shift is zero, and both examples are limited to rotationally symmetric output functions and lateral shifts along a single axis. A primary objective of this dissertation is to expand design procedures to overcome these constraints for creation of additional novel dynamic freeform optical systems. The optical performance of several example systems is characterized through experimental testing of diamond-machined freeform elements. Furthermore, as the advantages offered by freeform systems are realized, there remain unknowns regarding performance sensitivity to several potential errors such as opto-mechanical alignment, surface form accuracy, and surface finish quality. To this end, this dissertation also includes individual tolerance analyses on each of these error

  1. Effect and interaction study of acetamiprid photodegradation using experimental design.

    Science.gov (United States)

    Tassalit, Djilali; Chekir, Nadia; Benhabiles, Ouassila; Mouzaoui, Oussama; Mahidine, Sarah; Merzouk, Nachida Kasbadji; Bentahar, Fatiha; Khalil, Abbas

    2016-10-01

    The methodology of experimental research was carried out using the MODDE 6.0 software to study the acetamiprid photodegradation depending on the operating parameters, such as the initial concentration of acetamiprid, concentration and type of the used catalyst and the initial pH of the medium. The results showed the importance of the pollutant concentration effect on the acetamiprid degradation rate. On the other hand, the amount and type of the used catalyst have a considerable influence on the elimination kinetics of this pollutant. The degradation of acetamiprid as an environmental pesticide pollutant via UV irradiation in the presence of titanium dioxide was assessed and optimized using response surface methodology with a D-optimal design. The acetamiprid degradation ratio was found to be sensitive to the different studied factors. The maximum value of discoloration under the optimum operating conditions was determined to be 99% after 300 min of UV irradiation.

  2. A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitis

    Science.gov (United States)

    Jameson, Bradford A.; McDonnell, James M.; Marini, Joseph C.; Korngold, Robert

    1994-04-01

    EXPERIMENTAL allergic encephalomyelitis (EAE) is an acute inflammatory autoimmune disease of the central nervous system that can be elicited in rodents and is the major animal model for the study of multiple sclerosis (MS)1,2. The pathogenesis of both EAE and MS directly involves the CD4+ helper T-cell subset3-5. Anti-CD4 monoclonal antibodies inhibit the development of EAE in rodents6-9, and are currently being used in human clinical trials for MS. We report here that similar therapeutic effects can be achieved in mice using a small (rationally designed) synthetic analogue of the CD4 protein surface. It greatly inhibits both clinical incidence and severity of EAE with a single injection, but does so without depletion of the CD4+ subset and without the inherent immunogenicity of an antibody. Furthermore, this analogue is capable of exerting its effects on disease even after the onset of symptoms.

  3. Statistics in experimental design, preprocessing, and analysis of proteomics data.

    Science.gov (United States)

    Jung, Klaus

    2011-01-01

    High-throughput experiments in proteomics, such as 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS), yield usually high-dimensional data sets of expression values for hundreds or thousands of proteins which are, however, observed on only a relatively small number of biological samples. Statistical methods for the planning and analysis of experiments are important to avoid false conclusions and to receive tenable results. In this chapter, the most frequent experimental designs for proteomics experiments are illustrated. In particular, focus is put on studies for the detection of differentially regulated proteins. Furthermore, issues of sample size planning, statistical analysis of expression levels as well as methods for data preprocessing are covered.

  4. Bayesian Optimal Experimental Design Using Multilevel Monte Carlo

    KAUST Repository

    Ben Issaid, Chaouki

    2015-05-12

    Experimental design can be vital when experiments are resource-exhaustive and time-consuming. In this work, we carry out experimental design in the Bayesian framework. To measure the amount of information that can be extracted from the data in an experiment, we use the expected information gain as the utility function, which specifically is the expected logarithmic ratio between the posterior and prior distributions. Optimizing this utility function enables us to design experiments that yield the most informative data about the model parameters. One of the major difficulties in evaluating the expected information gain is that it naturally involves nested integration over a possibly high dimensional domain. We use the Multilevel Monte Carlo (MLMC) method to accelerate the computation of the nested high dimensional integral. The advantages are twofold. First, MLMC can significantly reduce the cost of the nested integral for a given tolerance, by using an optimal sample distribution among different sample averages of the inner integrals. Second, the MLMC method imposes fewer assumptions, such as the asymptotic concentration of posterior measures, required for instance by the Laplace approximation (LA). We test the MLMC method using two numerical examples. The first example is the design of sensor deployment for a Darcy flow problem governed by a one-dimensional Poisson equation. We place the sensors in the locations where the pressure is measured, and we model the conductivity field as a piecewise constant random vector with two parameters. The second one is chemical Enhanced Oil Recovery (EOR) core flooding experiment assuming homogeneous permeability. We measure the cumulative oil recovery, from a horizontal core flooded by water, surfactant and polymer, for different injection rates. The model parameters consist of the endpoint relative permeabilities, the residual saturations and the relative permeability exponents for the three phases: water, oil and

  5. EXPERIMENTAL RESEARCH REGARDING LEATHER APPLICATIONS IN PRODUCT DESIGN

    Directory of Open Access Journals (Sweden)

    PRALEA Jeni

    2015-05-01

    Full Text Available This paper presents the role and importance of experimental research in design activity. The designer, as a researcher and a project manager, proposes to establish a relationship between functional-aesthetic-constructive-technological-economic,based on the aesthetic possibilities of the materials used for the experiments. With the aim to identify areas for the application of leather waste resulted from the production process, the paper presents experiments conducted with this material in combination with wood, by using different techniques that lead to different aesthetic effects. Identifying the areas to use and creating products from leather and/or wood waste, is based on the properties of these materials. Leather, the subject of these experiments, has the advantage that it can be used on both sides. Tactile differences of the two sides of this material has both aesthetical and functional advantages, which makes it suitable for applications on products that meet the requirements of "design for all". With differentiated tactile characteristics, in combination with other materials, for these experiments wood, easily "read touch" products can be generated to help people with certain disabilities. Thus, experiments presented in this paper allows the establishment of aesthetic schemes applicable to products that are friendly both with the environment (based on the reuse of wood and leather waste and with the users (can be used as applications, accessories and concepts of products for people with certain disabilities. The designer’s choices or decisions can be based on the results of this experiment. The experiment enables the designer to develop creative, innovative and environmentally friendly products.

  6. Experimental Verification of Current Shear Design Equations for HSRC Beams

    Directory of Open Access Journals (Sweden)

    Attaullah Shah

    2012-07-01

    Full Text Available Experimental research on the shear capacity of HSRC (High Strength Reinforced Concrete beams is relatively very limited as compared to the NSRC (Normal Strength Reinforced Concrete beams. Most of the Building Codes determine the shear strength of HSRC with the help of empirical equations based on experimental work of NSRC beams and hence these equations are generally regarded as un-conservative for HSRC beams particularly at low level of longitudinal reinforcement. In this paper, 42 beams have been tested in two sets, such that in 21 beams no transverse reinforcement has been used, whereas in the remaining 21 beams, minimum transverse reinforcement has been used as per ACI-318 (American Concrete Institute provisions. Two values of compressive strength 52 and 61 MPa, three values of longitudinal steel ratio and seven values of shear span to depth ratio have been have been used. The beams were tested under concentrated load at the mid span. The results are compared with the equations proposed by different international building codes like ACI, AASHTO LRFD, EC (Euro Code, Canadian Code and Japanese Code for shear strength of HSRC beams.From comparison, it has been observed that some codes are less conservative for shear design of HSRC beams and further research is required to rationalize these equations.

  7. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2011-12-31

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This proposal will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; we will perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; we will perform material characterizations and oxidation/corrosion tests; and we will demonstrate our new Thermal barrier coating (TBC) systems experimentally under Integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed High Temperature/High Pressure Durability Test Rig under real syngas product compositions.

  8. Experimental studies of tuned particle damper: Design and characterization

    Science.gov (United States)

    Zhang, Kai; Xi, Yanhui; Chen, Tianning; Ma, Zhihao

    2018-01-01

    To better suppress the structural vibration in the micro vibration and harsh environment, a new type of damper, tuned particle damper (TPD), was designed by combining the advantage of classical dynamic vibration absorber (DVA) and particle damper (PD). An equivalent theoretical model was established to describe the dynamic behavior of a cantilever system treated with TPD. By means of a series of sine sweep tests, the dynamic characteristic of TPD under different excitation intensity was explored and the damping performance of TPD was investigated by comparing with classical DVA and PD with the same mass ratio. Experimental results show that with the increasing of excitation intensity TPD shows two different dynamic characteristics successively, i.e., PD-like and DVA-like. TPD shows a wider suppression frequency band than classical DVA and better practicability than PD in the micro vibration environment. Moreover, to characterize the dynamic characteristic of TPD, a simple evaluation of the equivalent dynamic mass and equivalent dynamic damping of the cantilever system treated with TPD was performed by fitting the experimental data to the presented theoretical model. Finally, based on the rheology behaviors of damping particles reported by the previous research results, an approximate phase diagram which shows the motion states of damping particles in TPD was employed to analyze the dynamic characteristic of TPD and several motion states of damping particles in TPD were presented via a high-speed camera.

  9. Process optimization of copper MOCVD using modeling experimental design

    Science.gov (United States)

    Mouche, Marie-José; Mermet, Jean-Luc; Pires, Fabrice; Richard, Emmanuel; Torres, Joaquin; Palleau, Jean; Braud, François

    1995-10-01

    An optimisation of copper CVD was carried out through the use of screening and modeling experimental designs. The copper precursor [Cu(hfac)tmvs] was delivered through a bubbler using hydrogen as carrier gas. Water vapour was used as reactant. Films were deposited on sputtered titanium nitride substrate. The influence of substrate temperature, carrier gas flow, water flow, water injection time and bubbler pressure were studied and led to experimental laws, which show the dependence of resistivity and deposition rate with any of these parameters. It was found that the optimum procedure was to inject water during a limited time at the beginning of the growth (typically 2 minutes, for an overall deposition time of 30 minutes). This improves the nucleation but avoids the oxidation of the film. Consequently, the resistivity is very low and the deposition rate is relatively high. For the optimum working point, in terms of resistivity (1.9 μΩ · cm after anneal), X-ray photoelectron spectroscopy (XPS) depth profiling indicates a pure copper phase. The adhesion on the TiN substrate was excellent according to the "Scotch tape" test.

  10. Simulation-based optimal Bayesian experimental design for nonlinear systems

    KAUST Repository

    Huan, Xun

    2013-01-01

    The optimal selection of experimental conditions is essential to maximizing the value of data for inference and prediction, particularly in situations where experiments are time-consuming and expensive to conduct. We propose a general mathematical framework and an algorithmic approach for optimal experimental design with nonlinear simulation-based models; in particular, we focus on finding sets of experiments that provide the most information about targeted sets of parameters.Our framework employs a Bayesian statistical setting, which provides a foundation for inference from noisy, indirect, and incomplete data, and a natural mechanism for incorporating heterogeneous sources of information. An objective function is constructed from information theoretic measures, reflecting expected information gain from proposed combinations of experiments. Polynomial chaos approximations and a two-stage Monte Carlo sampling method are used to evaluate the expected information gain. Stochastic approximation algorithms are then used to make optimization feasible in computationally intensive and high-dimensional settings. These algorithms are demonstrated on model problems and on nonlinear parameter inference problems arising in detailed combustion kinetics. © 2012 Elsevier Inc.

  11. Efficient experimental designs for isotropic generalized diffusion tensor MRI (IGDTI).

    Science.gov (United States)

    Avram, Alexandru V; Sarlls, Joelle E; Hutchinson, Elizabeth; Basser, Peter J

    2018-01-01

    We propose a new generalized diffusion tensor imaging (GDTI) experimental design and analysis framework for efficiently measuring orientationally averaged diffusion-weighted images (DWIs), which remove bulk signal modulations attributed to diffusion anisotropy and quantify isotropic higher-order diffusion tensors (HOT). We illustrate how this framework accelerates the clinical measurement of rotation-invariant tissue microstructural parameters derived from HOT, such as the HOT-Trace and the mean t-kurtosis. For a large range of b-values, we compare orientationally averaged DWIs measured with high angular resolution diffusion imaging to those obtained with the proposed isotropic GDTI (IGDTI) experimental design. We compare rotation-invariant microstructural parameters measured with IGDTI to those derived from HOTs measured explicitly with GDTI. In both fixed-brain microimaging and in vivo clinical experiments, IGDTI accurately quantifies mean apparent diffusion coefficient (mADC)-weighted DWIs over a wide range of b-values and allows efficient computation of HOT-derived scalar tissue parameters from a small number of DWIs. IGDTI provides direct and accurate estimates of orientationally averaged tissue water mobilities over a wide range of b-values. This efficient method may enable new, sensitive, and quantitative assessments for clinical applications in which changes in mADC can be observe,d such as detecting and characterizing stroke, cancers, and neurodegenerative diseases. Magn Reson Med 79:180-194, 2018. Published 2017. This article is a U.S. Government work and is in the public domain in the USA. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

  12. MicroarrayDesigner: an online search tool and repository for near-optimal microarray experimental designs.

    Science.gov (United States)

    Sacan, Ahmet; Ferhatosmanoglu, Nilgun; Ferhatosmanoglu, Hakan

    2009-09-22

    Dual-channel microarray experiments are commonly employed for inference of differential gene expressions across varying organisms and experimental conditions. The design of dual-channel microarray experiments that can help minimize the errors in the resulting inferences has recently received increasing attention. However, a general and scalable search tool and a corresponding database of optimal designs were still missing. An efficient and scalable search method for finding near-optimal dual-channel microarray designs, based on a greedy hill-climbing optimization strategy, has been developed. It is empirically shown that this method can successfully and efficiently find near-optimal designs. Additionally, an improved interwoven loop design construction algorithm has been developed to provide an easily computable general class of near-optimal designs. Finally, in order to make the best results readily available to biologists, a continuously evolving catalog of near-optimal designs is provided. A new search algorithm and database for near-optimal microarray designs have been developed. The search tool and the database are accessible via the World Wide Web at http://db.cse.ohio-state.edu/MicroarrayDesigner. Source code and binary distributions are available for academic use upon request.

  13. MicroarrayDesigner: an online search tool and repository for near-optimal microarray experimental designs

    Directory of Open Access Journals (Sweden)

    Ferhatosmanoglu Nilgun

    2009-09-01

    Full Text Available Abstract Background Dual-channel microarray experiments are commonly employed for inference of differential gene expressions across varying organisms and experimental conditions. The design of dual-channel microarray experiments that can help minimize the errors in the resulting inferences has recently received increasing attention. However, a general and scalable search tool and a corresponding database of optimal designs were still missing. Description An efficient and scalable search method for finding near-optimal dual-channel microarray designs, based on a greedy hill-climbing optimization strategy, has been developed. It is empirically shown that this method can successfully and efficiently find near-optimal designs. Additionally, an improved interwoven loop design construction algorithm has been developed to provide an easily computable general class of near-optimal designs. Finally, in order to make the best results readily available to biologists, a continuously evolving catalog of near-optimal designs is provided. Conclusion A new search algorithm and database for near-optimal microarray designs have been developed. The search tool and the database are accessible via the World Wide Web at http://db.cse.ohio-state.edu/MicroarrayDesigner. Source code and binary distributions are available for academic use upon request.

  14. Experimental Charging Behavior of Orion UltraFlex Array Designs

    Science.gov (United States)

    Golofaro, Joel T.; Vayner, Boris V.; Hillard, Grover B.

    2010-01-01

    The present ground based investigations give the first definitive look describing the charging behavior of Orion UltraFlex arrays in both the Low Earth Orbital (LEO) and geosynchronous (GEO) environments. Note the LEO charging environment also applies to the International Space Station (ISS). The GEO charging environment includes the bounding case for all lunar mission environments. The UltraFlex photovoltaic array technology is targeted to become the sole power system for life support and on-orbit power for the manned Orion Crew Exploration Vehicle (CEV). The purpose of the experimental tests is to gain an understanding of the complex charging behavior to answer some of the basic performance and survivability issues to ascertain if a single UltraFlex array design will be able to cope with the projected worst case LEO and GEO charging environments. Stage 1 LEO plasma testing revealed that all four arrays successfully passed arc threshold bias tests down to -240 V. Stage 2 GEO electron gun charging tests revealed that only the front side area of indium tin oxide coated array designs successfully passed the arc frequency tests

  15. Thermal design of horizontal tube boilers: numerical and experimental investigation

    International Nuclear Information System (INIS)

    Roser, Robert

    1999-01-01

    This work concerns the thermal design of kettle re-boilers. Current methods are highly inaccurate, regarded to the correlations for external heat transfer coefficient at one tube scale, as well as to two-phase flow modelling at boiler scale. The aim of this work is to improve these thermal design methods. It contains an experimental investigation with typical operating conditions of such equipment: an hydrocarbon (n-pentane) with low mass flux. This investigation has lead to characterize the local flow pattern through void fraction measurements and, from this, to develop correlations for void fraction, pressure drop and heat transfer coefficient. The approach is original, since the developed correlations are based on the liquid velocity at minimum cross section area between tubes, as variable characterizing the hydrodynamic effects on pressure drop and heat transfer coefficient. These correlations are shown to give much better results than those suggested up to now in the literature, which are empirical transpositions from methods developed for inside tube flows. Furthermore, the numerical code MC3D has been applied using the correlations developed in this work, leading to a modelization of the two-phase flow in the boiler, which is a significant progress compared to current simplified methods. (author) [fr

  16. Tabletop Games: Platforms, Experimental Games and Design Recommendations

    Science.gov (United States)

    Haller, Michael; Forlines, Clifton; Koeffel, Christina; Leitner, Jakob; Shen, Chia

    While the last decade has seen massive improvements in not only the rendering quality, but also the overall performance of console and desktop video games, these improvements have not necessarily led to a greater population of video game players. In addition to continuing these improvements, the video game industry is also constantly searching for new ways to convert non-players into dedicated gamers. Despite the growing popularity of computer-based video games, people still love to play traditional board games, such as Risk, Monopoly, and Trivial Pursuit. Both video and board games have their strengths and weaknesses, and an intriguing conclusion is to merge both worlds. We believe that a tabletop form-factor provides an ideal interface for digital board games. The design and implementation of tabletop games will be influenced by the hardware platforms, form factors, sensing technologies, as well as input techniques and devices that are available and chosen. This chapter is divided into three major sections. In the first section, we describe the most recent tabletop hardware technologies that have been used by tabletop researchers and practitioners. In the second section, we discuss a set of experimental tabletop games. The third section presents ten evaluation heuristics for tabletop game design.

  17. Numerical and experimental design of coaxial shallow geothermal energy systems

    Science.gov (United States)

    Raghavan, Niranjan

    Geothermal Energy has emerged as one of the front runners in the energy race because of its performance efficiency, abundance and production competitiveness. Today, geothermal energy is used in many regions of the world as a sustainable solution for decreasing dependence on fossil fuels and reducing health hazards. However, projects related to geothermal energy have not received their deserved recognition due to lack of computational tools associated with them and economic misconceptions related to their installation and functioning. This research focuses on numerical and experimental system design analysis of vertical shallow geothermal energy systems. The driving force is the temperature difference between a finite depth beneath the earth and its surface stimulates continuous exchange of thermal energy from sub-surface to the surface (a geothermal gradient is set up). This heat gradient is captured by the circulating refrigerant and thus, tapping the geothermal energy from shallow depths. Traditionally, U-bend systems, which consist of two one-inch pipes with a U-bend connector at the bottom, have been widely used in geothermal applications. Alternative systems include coaxial pipes (pipe-in-pipe) that are the main focus of this research. It has been studied that coaxial pipes have significantly higher thermal performance characteristics than U-bend pipes, with comparative production and installation costs. This makes them a viable design upgrade to the traditional piping systems. Analytical and numerical heat transfer analysis of the coaxial system is carried out with the help of ABAQUS software. It is tested by varying independent parameters such as materials, soil conditions and effect of thermal contact conductance on heat transfer characteristics. With the above information, this research aims at formulating a preliminary theoretical design setup for an experimental study to quantify and compare the heat transfer characteristics of U-bend and coaxial

  18. System design overview of JAXA small supersonic experimental airplane (NEXST-1)

    OpenAIRE

    Takami, Hikaru; 高見 光

    2007-01-01

    The system of JAXA small supersonic experimental airplane (NEXST-1: National EXperimental Supersonic Transport-1) has been briefly explained. Some design problems that the designers have encountered have also been briefly explained.

  19. Estimating Intervention Effects across Different Types of Single-Subject Experimental Designs: Empirical Illustration

    Science.gov (United States)

    Moeyaert, Mariola; Ugille, Maaike; Ferron, John M.; Onghena, Patrick; Heyvaert, Mieke; Beretvas, S. Natasha; Van den Noortgate, Wim

    2015-01-01

    The purpose of this study is to illustrate the multilevel meta-analysis of results from single-subject experimental designs of different types, including AB phase designs, multiple-baseline designs, ABAB reversal designs, and alternating treatment designs. Current methodological work on the meta-analysis of single-subject experimental designs…

  20. Design review of the Brazilian Experimental Solar Telescope

    Science.gov (United States)

    Dal Lago, A.; Vieira, L. E. A.; Albuquerque, B.; Castilho, B.; Guarnieri, F. L.; Cardoso, F. R.; Guerrero, G.; Rodríguez, J. M.; Santos, J.; Costa, J. E. R.; Palacios, J.; da Silva, L.; Alves, L. R.; Costa, L. L.; Sampaio, M.; Dias Silveira, M. V.; Domingues, M. O.; Rockenbach, M.; Aquino, M. C. O.; Soares, M. C. R.; Barbosa, M. J.; Mendes, O., Jr.; Jauer, P. R.; Branco, R.; Dallaqua, R.; Stekel, T. R. C.; Pinto, T. S. N.; Menconi, V. E.; Souza, V. M. C. E. S.; Gonzalez, W.; Rigozo, N.

    2015-12-01

    The Brazilian's National Institute for Space Research (INPE), in collaboration with the Engineering School of Lorena/University of São Paulo (EEL/USP), the Federal University of Minas Gerais (UFMG), and the Brazilian's National Laboratory for Astrophysics (LNA), is developing a solar vector magnetograph and visible-light imager to study solar processes through observations of the solar surface magnetic field. The Brazilian Experimental Solar Telescope is designed to obtain full disk magnetic field and line-of-sight velocity observations in the photosphere. Here we discuss the system requirements and the first design review of the instrument. The instrument is composed by a Ritchey-Chrétien telescope with a 500 mm aperture and 4000 mm focal length. LCD polarization modulators will be employed for the polarization analysis and a tuning Fabry-Perot filter for the wavelength scanning near the Fe II 630.25 nm line. Two large field-of-view, high-resolution 5.5 megapixel sCMOS cameras will be employed as sensors. Additionally, we describe the project management and system engineering approaches employed in this project. As the magnetic field anchored at the solar surface produces most of the structures and energetic events in the upper solar atmosphere and significantly influences the heliosphere, the development of this instrument plays an important role in advancing scientific knowledge in this field. In particular, the Brazilian's Space Weather program will benefit most from the development of this technology. We expect that this project will be the starting point to establish a strong research program on Solar Physics in Brazil. Our main aim is to progressively acquire the know-how to build state-of-art solar vector magnetograph and visible-light imagers for space-based platforms.

  1. Tokamak experimental power reactor conceptual design. Volume I

    International Nuclear Information System (INIS)

    1976-08-01

    A conceptual design has been developed for a tokamak Experimental Power Reactor to operate at net electrical power conditions with a plant capacity factor of 50 percent for 10 years. The EPR operates in a pulsed mode at a frequency of approximately 1/min., with an approximate 75 percent duty cycle, is capable of producing approximately 72 MWe and requires 42 MWe. The annual tritium consumption is 16 kg. The EPR vacuum chamber is 6.25 m in major radius and 2.4 m in minor radius, is constructed of 2-cm thick stainless steel, and has 2-cm thick detachable, beryllium-coated coolant panels mounted on the interior. An 0.28 m stainless steel blanket and a shield ranging from 0.6 to 1.0 m surround the vacuum vessel. The coolant is H 2 O. Sixteen niobium-titanium superconducting toroidal-field coils provide a field of 10 T at the coil and 4.47 T at the plasma. Superconducting ohmic-heating and equilibrium-field coils provide 135 V-s to drive the plasma current. Plasma heating is accomplished by 12 neutral beam-injectors, which provide 60 MW. The energy transfer and storage system consists of a central superconducting storage ring, a homopolar energy storage unit, and a variety of inductor-converters

  2. Design and experimental test to ecological bricks based on organic and inorganic materials

    OpenAIRE

    Pérez, Herminio; Pimentel, Kristi; De Meza, Olga; Hernández Korner, Mario

    2017-01-01

    This article describes the experimental design and testing of ecological blocks based on organic and inorganic materials. For the development of this project we formulated two experimental designs for the manufacture of blocks specifying the dimensions of the blocks, proportions, materials, and also the weight of those materials, then we brought those designs to the reality manufacturing 8 blocks for each experimental design. Later the testing of compressive strength of the blocks was made fo...

  3. Experimental studies on critical heat flux in support of the advanced fuel design

    International Nuclear Information System (INIS)

    Leung, L.

    2004-01-01

    Experimental studies have been performed to obtain data on critical heat flux (CHF) in CANFLEX bundles. These data have been used to develop the CHF correlation, which is being applied in design analyses of the advanced CANDU fuel. This paper summarizes previous experimental CHF studies that are relevant to design calculations. Some experimental data are shown to illustrate various separate effects on CHF. (author)

  4. 14 CFR 437.85 - Allowable design changes; modification of an experimental permit.

    Science.gov (United States)

    2010-01-01

    ... Conditions of an Experimental Permit § 437.85 Allowable design changes; modification of an experimental... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Allowable design changes; modification of an experimental permit. 437.85 Section 437.85 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION...

  5. City Connects: Building an Argument for Effects on Student Achievement with a Quasi-Experimental Design

    Science.gov (United States)

    Walsh, Mary; Raczek, Anastasia; Sibley, Erin; Lee-St. John, Terrence; An, Chen; Akbayin, Bercem; Dearing, Eric; Foley, Claire

    2015-01-01

    While randomized experimental designs are the gold standard in education research concerned with causal inference, non-experimental designs are ubiquitous. For researchers who work with non-experimental data and are no less concerned for causal inference, the major problem is potential omitted variable bias. In this presentation, the authors…

  6. MUP, CEC-DES, STRADE. Codes for uncertainty propagation, experimental design and stratified random sampling techniques

    International Nuclear Information System (INIS)

    Amendola, A.; Astolfi, M.; Lisanti, B.

    1983-01-01

    The report describes the how-to-use of the codes: MUP (Monte Carlo Uncertainty Propagation) for uncertainty analysis by Monte Carlo simulation, including correlation analysis, extreme value identification and study of selected ranges of the variable space; CEC-DES (Central Composite Design) for building experimental matrices according to the requirements of Central Composite and Factorial Experimental Designs; and, STRADE (Stratified Random Design) for experimental designs based on the Latin Hypercube Sampling Techniques. Application fields, of the codes are probabilistic risk assessment, experimental design, sensitivity analysis and system identification problems

  7. Nanofluid pool boiling: a review and experimental design

    International Nuclear Information System (INIS)

    Strack, J.

    2012-01-01

    Nanofluids consist of nano-scale particles dispersed in a liquid which exhibit the potential for enhanced boiling heat transfer and critical heat flux (CHF). Past experimental results have shown conflicting results and the underlying mechanisms are not fully understood, warranting further study. An experimental program for the study of nanofluid pool boiling is currently under development at McMaster University. Recent literature is briefly reviewed to outline the motivation of the study and a brief description of the future experimental facility is provided. (author)

  8. Artificial Warming of Arctic Meadow under Pollution Stress: Experimental design

    Science.gov (United States)

    Moni, Christophe; Silvennoinen, Hanna; Fjelldal, Erling; Brenden, Marius; Kimball, Bruce; Rasse, Daniel

    2014-05-01

    Boreal and arctic terrestrial ecosystems are central to the climate change debate, notably because future warming is expected to be disproportionate as compared to world averages. Likewise, greenhouse gas (GHG) release from terrestrial ecosystems exposed to climate warming is expected to be the largest in the arctic. Artic agriculture, in the form of cultivated grasslands, is a unique and economically relevant feature of Northern Norway (e.g. Finnmark Province). In Eastern Finnmark, these agro-ecosystems are under the additional stressor of heavy metal and sulfur pollution generated by metal smelters of NW Russia. Warming and its interaction with heavy metal dynamics will influence meadow productivity, species composition and GHG emissions, as mediated by responses of soil microbial communities. Adaptation and mitigation measurements will be needed. Biochar application, which immobilizes heavy metal, is a promising adaptation method to promote positive growth response in arctic meadows exposed to a warming climate. In the MeadoWarm project we conduct an ecosystem warming experiment combined to biochar adaptation treatments in the heavy-metal polluted meadows of Eastern Finnmark. In summary, the general objective of this study is twofold: 1) to determine the response of arctic agricultural ecosystems under environmental stress to increased temperatures, both in terms of plant growth, soil organisms and GHG emissions, and 2) to determine if biochar application can serve as a positive adaptation (plant growth) and mitigation (GHG emission) strategy for these ecosystems under warming conditions. Here, we present the experimental site and the designed open-field warming facility. The selected site is an arctic meadow located at the Svanhovd Research station less than 10km west from the Russian mining city of Nikel. A splitplot design with 5 replicates for each treatment is used to test the effect of biochar amendment and a 3oC warming on the Arctic meadow. Ten circular

  9. Regression Models and Experimental Designs : A Tutorial for Simulation Analaysts

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    2006-01-01

    This tutorial explains the basics of linear regression models. especially low-order polynomials. and the corresponding statistical designs. namely, designs of resolution III, IV, V, and Central Composite Designs (CCDs).This tutorial assumes 'white noise', which means that the residuals of the fitted

  10. Towards an optimal experimental design for N2O model calibration during biological nitrogen removal

    DEFF Research Database (Denmark)

    Domingo Felez, Carlos; Valverde Pérez, Borja; Plósz, Benedek G.

    substrates. Improving experimental designs for model calibration reduces prediction uncertainties. Moreover, the individual analysis of autotrophic and heterotrophic contribution to the total NO and N2O pool was assessed for already proposed model structures under different experimental scenarios...

  11. Conceptual design study of fusion experimental reactor (FY86 FER)

    International Nuclear Information System (INIS)

    Miki, Nobuharu; Iida, Fumio; Suzuki, Shohei; Wachi, Yoshihiro; Toyoda, Katsuyoshi; Hashizume, Takashi; Konno, Masayuki.

    1987-09-01

    This report summarizes the FER magnet design which was conducted last year (1986). Main objective of the new FER design is to have better cost performance of the machine. The physics assumptions are reviewed to reduce risks. Optimization of the physics design and improvements of the engineering design have been done without changing missions of the device. After a preliminary investigation for the optimization and improvements, six FER concepts have been developed to establish the improved design point, and have been studied in more detail. In the magnet design, the improvements of superconducting magnet design were mainly investigated to reduce the reactor size. A normal conductor was studied as an alternative option for appling to the special poloidal field coils that were located on the interior to the toroidal field coils. Some improvements were made on the superconducting magnet design. Based on the preliminary investigation, the magnet design specifications have been modified somewhat. The conceptual design of the magnet system components have been done for the candidate FER concepts. (author)

  12. Verification of aseismic design model by using experimental results

    International Nuclear Information System (INIS)

    Mizuno, N.; Sugiyama, N.; Suzuki, T.; Shibata, Y.; Miura, K.; Miyagawa, N.

    1985-01-01

    A lattice model is applied as an analysis model for an aseismic design of the Hamaoka nuclear reactor building. With object to verify an availability of this design model, two reinforced concrete blocks are constructed on the ground and the forced vibration tests are carried out. The test results are well followed by simulation analysis using the lattice model. Damping value of the ground obtained from the test is more conservative than the design value. (orig.)

  13. Experimental verification of Space Platform battery discharger design optimization

    Science.gov (United States)

    Sable, Dan M.; Deuty, Scott; Lee, Fred C.; Cho, Bo H.

    1991-01-01

    The detailed design of two candidate topologies for the Space Platform battery discharger, a four module boost converter (FMBC) and a voltage-fed push-pull autotransformer (VFPPAT), is presented. Each has unique problems. The FMBC requires careful design and analysis in order to obtain good dynamic performance. This is due to the presence of a right-half-plane (RHP) zero in the control-to-output transfer function. The VFPPAT presents a challenging power stage design in order to yield high efficiency and light component weight. The authors describe the design of each of these converters and compare their efficiency, weight, and dynamic characteristics.

  14. Critical Zone Experimental Design to Assess Soil Processes and Function

    Science.gov (United States)

    Banwart, Steve

    2010-05-01

    experimental design studies soil processes across the temporal evolution of the soil profile, from its formation on bare bedrock, through managed use as productive land to its degradation under longstanding pressures from intensive land use. To understand this conceptual life cycle of soil, we have selected 4 European field sites as Critical Zone Observatories. These are to provide data sets of soil parameters, processes and functions which will be incorporated into the mathematical models. The field sites are 1) the BigLink field station which is located in the chronosequence of the Damma Glacier forefield in alpine Switzerland and is established to study the initial stages of soil development on bedrock; 2) the Lysina Catchment in the Czech Republic which is representative of productive soils managed for intensive forestry, 3) the Fuchsenbigl Field Station in Austria which is an agricultural research site that is representative of productive soils managed as arable land and 4) the Koiliaris Catchment in Crete, Greece which represents degraded Mediterranean region soils, heavily impacted by centuries of intensive grazing and farming, under severe risk of desertification.

  15. Design, experimentation, and modeling of a novel continuous biodrying process

    Science.gov (United States)

    Navaee-Ardeh, Shahram

    Massive production of sludge in the pulp and paper industry has made the effective sludge management increasingly a critical issue for the industry due to high landfill and transportation costs, and complex regulatory frameworks for options such as sludge landspreading and composting. Sludge dewatering challenges are exacerbated at many mills due to improved in-plant fiber recovery coupled with increased production of secondary sludge, leading to a mixed sludge with a high proportion of biological matter which is difficult to dewater. In this thesis, a novel continuous biodrying reactor was designed and developed for drying pulp and paper mixed sludge to economic dry solids level so that the dried sludge can be economically and safely combusted in a biomass boiler for energy recovery. In all experimental runs the economic dry solids level was achieved, proving the process successful. In the biodrying process, in addition to the forced aeration, the drying rates are enhanced by biological heat generated through the microbial activity of mesophilic and thermophilic microorganisms naturally present in the porous matrix of mixed sludge. This makes the biodrying process more attractive compared to the conventional drying techniques because the reactor is a self-heating process. The reactor is divided into four nominal compartments and the mixed sludge dries as it moves downward in the reactor. The residence times were 4-8 days, which are 2-3 times shorter than the residence times achieved in a batch biodrying reactor previously studied by our research group for mixed sludge drying. A process variable analysis was performed to determine the key variable(s) in the continuous biodrying reactor. Several variables were investigated, namely: type of biomass feed, pH of biomass, nutrition level (C/N ratio), residence times, recycle ratio of biodried sludge, and outlet relative humidity profile along the reactor height. The key variables that were identified in the continuous

  16. Findings in Experimental Psychology as Functioning Principles of Theatrical Design.

    Science.gov (United States)

    Caldwell, George

    A gestalt approach to theatrical design seems to provide some ready and stable explanations for a number of issues in the scenic arts. Gestalt serves as the theoretical base for a number of experiments in psychology whose findings appear to delineate the principles of art to be used in scene design. The fundamental notion of gestalt theory…

  17. The experimental design of the Missouri Ozark Forest Ecosystem Project

    Science.gov (United States)

    Steven L. Sheriff; Shuoqiong. He

    1997-01-01

    The Missouri Ozark Forest Ecosystem Project (MOFEP) is an experiment that examines the effects of three forest management practices on the forest community. MOFEP is designed as a randomized complete block design using nine sites divided into three blocks. Treatments of uneven-aged, even-aged, and no-harvest management were randomly assigned to sites within each block...

  18. Return to Our Roots: Raising Radishes To Teach Experimental Design.

    Science.gov (United States)

    Stallings, William M.

    To provide practice in making design decisions, collecting and analyzing data, and writing and documenting results, a professor of statistics has his graduate students in statistics and research methodology classes design and perform an experiment on the effects of fertilizers on the growth of radishes. This project has been required of students…

  19. Gunnar Aagaard Andersen: Commercial Design and Experimental Art

    DEFF Research Database (Denmark)

    Gether, Vibeke Petersen

    2016-01-01

    in Copenhagen and the magazine Mobilia. These enterprises were pioneers within both the commercial–industrial creative field and experimental art from the 1950s. The industrial process, from idea and experiment to production,as well as the expanded field of visual art, was demonstrated in concrete painting...

  20. Experimental and numerical analysis for optimal design parameters ...

    Indian Academy of Sciences (India)

    Rajneesh Kaushal

    using experimental data, multiple regression analysis car- ried out by the software has given the following polynomial equations in terms of actual factors ... compounded amalgamation with autonomous variables which involves first and second order polynomials and can have abounding maxima points. Also, Eqs. (9) and ...

  1. Los Alamos Experimental Engineering Waste Burial Facility: design considerations and preliminary experimental plan

    International Nuclear Information System (INIS)

    DePoorter, G.L.

    1981-01-01

    The Experimental Engineered Waste Burial Facility is a field test site where generic experiments can be performed on several scales to get the basic information necessary to understand the processes occurring in low-level waste disposal facilities. The experiments include hydrological, chemical, mechanical, and biological factors. In order to separate these various factors in the experiments and to extrapolate the experimental results to actual facilities, experiments will be performed on several different scales

  2. Flexible graphical assessment of experimental designs in R: The vdg package

    NARCIS (Netherlands)

    Schoonees, P.C. (Pieter C.); N.J. Le Roux (Niël); Coetzer, R.L.J. (Roelof L. J.)

    2016-01-01

    textabstractThe R package vdg provides a flexible interface for producing various graphical summaries of the prediction variance associated with specific linear model specifications and experimental designs. These methods include variance dispersion graphs, fraction of design space plots and

  3. Conceptual design of blanket structures for fusion experimental reactor (FER)

    International Nuclear Information System (INIS)

    1984-03-01

    Conceptual design study for in-vessel components including tritium breeding blanket of FER has been carried out. The objective of this study is to obtain the engineering and technological data for selecting the reactor concept and for its construction by investigating fully and broadly. The design work covers in-vessel components (such as tritium breeding blanket, first wall, shield, divertor and blanket test module), remote handling system and tritium system. The designs of those components and systems are accomplished in consideration of their accomodation to whole reactor system and problems for furthur study are clarified. (author)

  4. Experimental design with applications in management, engineering and the sciences

    CERN Document Server

    Berger, Paul D; Celli, Giovana B

    2018-01-01

    This text introduces and provides instruction on the design and analysis of experiments for a broad audience. Formed by decades of teaching, consulting, and industrial experience in the Design of Experiments field, this new edition contains updated examples, exercises, and situations covering the science and engineering practice. This text minimizes the amount of mathematical detail, while still doing full justice to the mathematical rigor of the presentation and the precision of statements, making the text accessible for those who have little experience with design of experiments and who need some practical advice on using such designs to solve day-to-day problems. Additionally, an intuitive understanding of the principles is always emphasized, with helpful hints throughout.

  5. Experimental characterisation of a novel viscoelastic rectifier design

    DEFF Research Database (Denmark)

    Jensen, Kristian Ejlebjærg; Okkels, Fridolin; Szabo, Peter

    2012-01-01

    A planar microfluidic system with contractions and obstacles is characterized in terms of anisotropic flow resistance due to viscoelastic effects. The working mechanism is illustrated using streak photography, while the diodicity performance is quantified by pressure drop measurements. The point ...... reproducibility and uncertainties of the experimental data prevent a direct comparison at low elasticity, where the flow is essentially two-dimensional. © 2012 American Institute of Physics....

  6. 78 FR 2893 - Endangered and Threatened Species: Designation of a Nonessential Experimental Population for...

    Science.gov (United States)

    2013-01-15

    ... Experimental Population for Middle Columbia River Steelhead above the Pelton Round Butte Hydroelectric Project... Counties, Oregon, and designate them as a nonessential experimental population (NEP) under the Endangered... (Secretary) to authorize the release of an experimental population of an endangered or threatened species...

  7. Experimental Evaluation of Three Designs of Electrodynamic Flexural Transducers.

    Science.gov (United States)

    Eriksson, Tobias J R; Laws, Michael; Kang, Lei; Fan, Yichao; Ramadas, Sivaram N; Dixon, Steve

    2016-08-25

    Three designs for electrodynamic flexural transducers (EDFT) for air-coupled ultrasonics are presented and compared. An all-metal housing was used for robustness, which makes the designs more suitable for industrial applications. The housing is designed such that there is a thin metal plate at the front, with a fundamental flexural vibration mode at ∼50 kHz. By using a flexural resonance mode, good coupling to the load medium was achieved without the use of matching layers. The front radiating plate is actuated electrodynamically by a spiral coil inside the transducer, which produces an induced magnetic field when an AC current is applied to it. The transducers operate without the use of piezoelectric materials, which can simplify manufacturing and prolong the lifetime of the transducers, as well as open up possibilities for high-temperature applications. The results show that different designs perform best for the generation and reception of ultrasound. All three designs produced large acoustic pressure outputs, with a recorded sound pressure level (SPL) above 120 dB at a 40 cm distance from the highest output transducer. The sensitivity of the transducers was low, however, with single shot signal-to-noise ratio ( SNR ) ≃ 15 dB in transmit-receive mode, with transmitter and receiver 40 cm apart.

  8. Design of an experimental incinerator for alpha waste

    International Nuclear Information System (INIS)

    Warren, J.H.

    1979-08-01

    An electrically heated controlled-air two-stage incinerator has been designed for burning small volumes (5 kg/h) of solid wastes. Distinguishing features of the design are compactness, relatively lightweight, and ease of assembly made possible by using prefabricated ceramic components to form two combustion chambers surrounded by packed fiber insulation within a steel case. Electric girdle heaters around the two combustion chambers provide 600 to 1000 0 C. These temperatures combined with controlled air give minimum ash entrainment and long combustion gas residence times to yield approx. 10 9 off-gas decontamination factors with conventional off-gas cleaning equipment. After decommissioning, the design allows for ease of disassembly and convenient disposal of the ceramic components. 24 figures, 1 table

  9. Summary of the experimental multi-purpose very high temperature gas cooled reactor design

    International Nuclear Information System (INIS)

    1984-12-01

    The report presents the design of Multi-purpose Very High Temperature Gas Cooled Reactor (the Experimental VHTR) based on the second stage of detailed design which was completed on March 1984, in the from of ''An application of reactor construction permit Appendix 8''. The Experimental VHTR is designed to satisfy with the design specification for the reactor thermal output 50 MW and reactor outlet temperature 950 0 C. The adequacy of the design is also checked by the safety analysis. The planning of plant system and safety is summarized such as safety design requirements and conformance with them, seismic design and plant arrangement. Concerning with the system of the Experimental VHTR the design basis, design data and components are described in the order. (author)

  10. Providing guidance in virtual lab experimentation : the case of an experiment design tool

    NARCIS (Netherlands)

    Efstathiou, Charalampos; Hovardas, Tasos; Xenofontos, Nikoletta A.; Zacharia, Zacharias C.; de Jong, Ton A.J.M.; Anjewierden, Anjo; van Riesen, Siswa A.N.

    2018-01-01

    The present study employed a quasi-experimental design to assess a computer-based tool, which was intended to scaffold the task of designing experiments when using a virtual lab for the process of experimentation. In particular, we assessed the impact of this tool on primary school students’

  11. An Experimental Verification of morphology of ibuprofen crystals from CAMD designed solvent

    DEFF Research Database (Denmark)

    Karunanithi, Arunprakash T.; Acquah, Charles; Achenie, Luke E.K.

    2007-01-01

    of crystals formed from solvents, necessitates additional experimental verification steps. In this work we report the experimental verification of crystal morphology for the case study, solvent design for ibuprofen crystallization, presented in Karunanithi et al. [2006. A computer-aided molecular design...

  12. A unifying experimental design for dissecting tree genomes.

    Science.gov (United States)

    Sun, Lidan; Zhu, Xuli; Zhang, Qixiang; Wu, Rongling

    2015-08-01

    Linkage mapping and association mapping are adopted as an approach of choice for dissecting complex traits, but each shows a limitation when used alone. We propose an open-pollinated (OP) family design to integrate these two approaches into an organizing framework. The design unifies the strengths of population and quantitative genetic studies for evolutionary inference and high-resolution gene mapping. It particularly suits genome dissection of forest trees given their extant populations that are mostly undomesticated. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Optimization of preservatives in a topical formulation using experimental design.

    Science.gov (United States)

    Rahali, Y; Pensé-Lhéritier, A-M; Mielcarek, C; Bensouda, Y

    2009-12-01

    Optimizing the preservative regime for a preparation requires the antimicrobial effectiveness of several preservative combinations to be determined. In this study, three preservatives were tested: benzoic acid, sorbic acid and benzylic alcohol. Their preservative effects were evaluated using the antimicrobial preservative efficacy test (challenge-test) of the European Pharmacopeia (EP). A D-optimal mixture design was used to provide a maximum of information from a limited number of experiments. The results of this study were analysed with the help of the Design Expert software and enabled us to formulate emulsions satisfying both requirements A and B of the EP.

  14. Interdisciplinary for Social Engagement: Art and Design Experimental Study

    Directory of Open Access Journals (Sweden)

    Hope Angelique Wells

    2015-12-01

    Full Text Available In this ever-changing world with a population of over seven billion, social equality, and environmental sustainability needs new innovative and inclusive solutions. Today, the interdisciplinary practice of art and design has the ability to raise social awareness and engagement in health-related issues. Art and design experiments with combining the traditional art methods with technology and interactive systems to communicate scientific research with problem solving goals. Creative interdisciplinary opens many doors to a variety of collaborative efforts in seeking proactive solutions to environmental and social issues.

  15. Experimental and Optimization Design of Offshore Drilling Seal

    Directory of Open Access Journals (Sweden)

    Zhang Yi

    2017-11-01

    Full Text Available Three-cone bit is the key equipment in the exploration of the oil in offshore drilling and exploration, the bearing system and the seal system are the critical components for the bit. Especially in the offshore drilling environment, the seal design need to be carefully considered. A multi-objective optimization design including orthogonal design method and F-test with finite element analysis for a three-cone bit seal is proposed. Firstly, the calculation method of optimization targets are given, including the minimization of maximum contact pressure and leakage rate analyzed by ANSYS and MATLAB respectively, to maximize seal life and reliability. Then, an orthogonal experiment approach is used to investigate the effects of the eleven parameters on the seal performance, and the influence degrees of the seal factors on the optimization targets have been confirmed by F-test, and the reasonable factors can be determined by the trend of the targets. Finally, in order to validate the analysis results, a new seal was designed and tested on a seal tester compared to the previous seal. In this test, the seal maximum interface temperature that reflects the position of maximum contact pressure can be obtained by using three high precision thermocouples. Both the experiment results and the numerical analyses proved that the maximum contact pressure and leakage rate of the improved seal have been reduced compared to the previous.

  16. Experimental Design for Sensitivity Analysis of Simulation Models

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    2001-01-01

    This introductory tutorial gives a survey on the use of statistical designs for what if-or sensitivity analysis in simulation.This analysis uses regression analysis to approximate the input/output transformation that is implied by the simulation model; the resulting regression model is also known as

  17. Tokamak experimental power reactor conceptual design. Volume II

    International Nuclear Information System (INIS)

    1976-08-01

    Volume II contains the following appendices: (1) summary of EPR design parameters, (2) impurity control, (3) plasma computational models, (4) structural support system, (5) materials considerations for the primary energy conversion system, (6) magnetics, (7) neutronics penetration analysis, (8) first wall stress analysis, (9) enrichment of isotopes of hydrogen by cryogenic distillation, and (10) noncircular plasma considerations

  18. Introduction to Experimental Design: Can You Smell Fear?

    Science.gov (United States)

    Willmott, Chris J. R.

    2011-01-01

    The ability to design appropriate experiments in order to interrogate a research question is an important skill for any scientist. The present article describes an interactive lecture-based activity centred around a comparison of two contrasting approaches to investigation of the question "Can you smell fear?" A poorly designed…

  19. Experimental design applied to the optimization and partial ...

    African Journals Online (AJOL)

    The objective of this work was to optimize the medium composition for maximum pectin-methylesterase (PME) production from a newly isolated strain of Penicillium brasilianum by submerged fermentation. A Plackett-Burman design was first used for the screening of most important factors, followed by a 23 full ...

  20. Creativity in Advertising Design Education: An Experimental Study

    Science.gov (United States)

    Cheung, Ming

    2011-01-01

    Have you ever thought about why qualities whose definitions are elusive, such as those of a sunset or a half-opened rose, affect us so powerfully? According to de Saussure (Course in general linguistics, 1983), the making of meanings is closely related to the production and interpretation of signs. All types of design, including advertising…

  1. Tokamak experimental power reactor conceptual design. Volume II

    Energy Technology Data Exchange (ETDEWEB)

    1976-08-01

    Volume II contains the following appendices: (1) summary of EPR design parameters, (2) impurity control, (3) plasma computational models, (4) structural support system, (5) materials considerations for the primary energy conversion system, (6) magnetics, (7) neutronics penetration analysis, (8) first wall stress analysis, (9) enrichment of isotopes of hydrogen by cryogenic distillation, and (10) noncircular plasma considerations. (MOW)

  2. The design status of CSNS experimental control system

    International Nuclear Information System (INIS)

    Jian Zhuang; Yuanping Chu; Dapeng Jin; Yuqian Liu; Yinhong Zhang; Zhuoyu Zhang; Kejun Zhu; Libin Ding; Lei Hu; Jiajie Li; Yali, Liu

    2012-01-01

    To meet the increasing demand from user community, China decided to build a world-class spallation neutron source, called CSNS (China Spallation Neutron Source). It can provide users a neutron scattering platform with high flux, wide wavelength range and high efficiency. CSNS construction is expected to start in 2011 and will last 6.5 years. The control system of CSNS is divided into accelerator control system and experimental control system. CSNS Experimental Control System is based on EPICS architecture, offering device operation and device debug interface, communication between devices, environment monitor, machine and personnel protection, interface to accelerator control system, overall system monitor and database service. The control system is divided into 4 parts, such as front control layer, local and global control layer based on EPICS, database and network service and the others. The front control layer is based on YOKOGAWA PLC and other controllers. EPICS includes local and global control layer provides all system control and information exchange. Embedded PLC YOKOGAWA RP61 and others is to be used as communication node between front layer and EPICS. Database service provides system configuration and historical data. From the experience of BESIII, MySQL is an option. The system will be developed in Dongguan, Guangdong province and Beijing. So VPN will be used to help development. Now, total 9 persons are working on this system. (authors)

  3. On the construction of experimental designs for a given task by jointly optimizing several quality criteria: Pareto-optimal experimental designs.

    Science.gov (United States)

    Sánchez, M S; Sarabia, L A; Ortiz, M C

    2012-11-19

    Experimental designs for a given task should be selected on the base of the problem being solved and of some criteria that measure their quality. There are several such criteria because there are several aspects to be taken into account when making a choice. The most used criteria are probably the so-called alphabetical optimality criteria (for example, the A-, E-, and D-criteria related to the joint estimation of the coefficients, or the I- and G-criteria related to the prediction variance). Selecting a proper design to solve a problem implies finding a balance among these several criteria that measure the performance of the design in different aspects. Technically this is a problem of multi-criteria optimization, which can be tackled from different views. The approach presented here addresses the problem in its real vector nature, so that ad hoc experimental designs are generated with an algorithm based on evolutionary algorithms to find the Pareto-optimal front. There is not theoretical limit to the number of criteria that can be studied and, contrary to other approaches, no just one experimental design is computed but a set of experimental designs all of them with the property of being Pareto-optimal in the criteria needed by the user. Besides, the use of an evolutionary algorithm makes it possible to search in both continuous and discrete domains and avoid the need of having a set of candidate points, usual in exchange algorithms. Copyright © 2012 Elsevier B.V. All rights reserved.

  4. Safety design of the experimental multi-purpose high-temperature gas cooled reactor

    International Nuclear Information System (INIS)

    Mitake, Susumu; Yamada, M.; Morimoto, T.

    1979-01-01

    Studies have been made on methods to implement a proper safety design for the experimental multi-purpose high-temperature gas-cooled reactor. The experimental reactor is an advanced reactor, because it not only is a helium gas-cooled reactor, but also has an objective to achieve a very high reactor outlet gas temperature (1,000 0 C). In addition, it is planned to perform various tests during operation of the experimental reactor. In Japan, safety design method have been established for application to light water reactor nuclear power plants, and the related criteria and regulations are fairly well defined. Accordingly, the design of the experimental high-temperature gas-cooled reactor is required to be based on the light water reactor safety design method, even though the experimental reactor is of a different type and purpose. In another word, it is required to design the experimental reactor to conform to the currently established safety design criteria and regulations, as well as satisfy the requirements for performance of the experimental reactor. In recent years, the Japan Atomic Energy Research Institute and the Fuji Electric Co., Ltd. have performed a series of studies for the safety design of the experimental reactor and the results are summarized in this paper. (author)

  5. High-power CMUTs: design and experimental verification.

    Science.gov (United States)

    Yamaner, F Yalçin; Olçum, Selim; Oğuz, H Kağan; Bozkurt, Ayhan; Köymen, Hayrettin; Atalar, Abdullah

    2012-06-01

    Capacitive micromachined ultrasonic transducers (CMUTs) have great potential to compete with piezoelectric transducers in high-power applications. As the output pressures increase, nonlinearity of CMUT must be reconsidered and optimization is required to reduce harmonic distortions. In this paper, we describe a design approach in which uncollapsed CMUT array elements are sized so as to operate at the maximum radiation impedance and have gap heights such that the generated electrostatic force can sustain a plate displacement with full swing at the given drive amplitude. The proposed design enables high output pressures and low harmonic distortions at the output. An equivalent circuit model of the array is used that accurately simulates the uncollapsed mode of operation. The model facilities the design of CMUT parameters for high-pressure output, without the intensive need for computationally involved FEM tools. The optimized design requires a relatively thick plate compared with a conventional CMUT plate. Thus, we used a silicon wafer as the CMUT plate. The fabrication process involves an anodic bonding process for bonding the silicon plate with the glass substrate. To eliminate the bias voltage, which may cause charging problems, the CMUT array is driven with large continuous wave signals at half of the resonant frequency. The fabricated arrays are tested in an oil tank by applying a 125-V peak 5-cycle burst sinusoidal signal at 1.44 MHz. The applied voltage is increased until the plate is about to touch the bottom electrode to get the maximum peak displacement. The observed pressure is about 1.8 MPa with -28 dBc second harmonic at the surface of the array.

  6. Gunnar Aagaard Andersen: Commercial Design and Experimental Art

    DEFF Research Database (Denmark)

    Gether, Vibeke Petersen

    2016-01-01

    in Copenhagen and the magazine Mobilia. These enterprises were pioneers within both the commercial–industrial creative field and experimental art from the 1950s. The industrial process, from idea and experiment to production,as well as the expanded field of visual art, was demonstrated in concrete painting...... and total decoration. These developments within the visual arts of the 1950s and 1960s were followed up by Paul Gadegaard, Dieter Roth, Arthur Köpcke and Paul Gernes, as well as by Aagaard Andersen himself.......Gunnar Aagaard Andersen’s relaxed approach both to art and to commercialised creativity positioned him centrally in the field where the two overlap. Other important players were the brothers Aage and Mads Eg Damgaard, who owned textile factories in Herning, the artistic textile firm Unika Væv...

  7. A new dietary model to study colorectal carcinogenesis: experimental design, food preparation, and experimental findings.

    Science.gov (United States)

    Rozen, P; Liberman, V; Lubin, F; Angel, S; Owen, R; Trostler, N; Shkolnik, T; Kritchevsky, D

    1996-01-01

    Experimental dietary studies of human colorectal carcinogenesis are usually based on the AIN-76A diet, which is dissimilar to human food in source, preparation, and content. The aims of this study were to examine the feasibility of preparing and feeding rats the diet of a specific human population at risk for colorectal neoplasia and to determine whether changes in the colonic morphology and metabolic contents would differ from those resulting from a standard rat diet. The mean daily food intake composition of a previously evaluated adenoma patient case-control study was used for the "human adenoma" (HA) experimental diet. Foods were prepared as for usual human consumption and processed by dehydration to the physical characteristics of an animal diet. Sixty-four female Sprague-Dawley rats were randomized and fed ad libitum the HA or the AIN-76A diet. Every eight weeks, eight rats from each group were sacrificed, and the colons and contents were examined. Analysis of the prepared food showed no significant deleterious changes; food intake and weight gain were similar in both groups. Compared with the controls, the colonic contents of rats fed the HA diet contained significantly less calcium, concentrations of neutral sterols, total lipids, and cholic and deoxycholic acids were increased, and there were no colonic histological changes other than significant epithelial hyperproliferation. This initial study demonstrated that the HA diet can be successfully processed for feeding to experimental animals and is acceptable and adequate for growth but induces significant metabolic and hyperproliferative changes in the rat colon. This dietary model may be useful for studies of human food, narrowing the gap between animal experimentation and human nutritional research.

  8. Statistical Approaches in Analysis of Variance: from Random Arrangements to Latin Square Experimental Design

    OpenAIRE

    Radu E. SESTRAŞ; Lorentz JÄNTSCHI; Sorana D. BOLBOACĂ

    2009-01-01

    Background: The choices of experimental design as well as of statisticalanalysis are of huge importance in field experiments. These are necessary tobe correctly in order to obtain the best possible precision of the results. Therandom arrangements, randomized blocks and Latin square designs werereviewed and analyzed from the statistical perspective of error analysis.Material and Method: Random arrangements, randomized block and Latinsquares experimental designs were used as field experiments. ...

  9. Experimental design and quality assurance: in situ fluorescence instrumentation

    Science.gov (United States)

    Conmy, Robyn N.; Del Castillo, Carlos E.; Downing, Bryan D.; Chen, Robert F.

    2014-01-01

    Both instrument design and capabilities of fluorescence spectroscopy have greatly advanced over the last several decades. Advancements include solid-state excitation sources, integration of fiber optic technology, highly sensitive multichannel detectors, rapid-scan monochromators, sensitive spectral correction techniques, and improve data manipulation software (Christian et al., 1981, Lochmuller and Saavedra, 1986; Cabniss and Shuman, 1987; Lakowicz, 2006; Hudson et al., 2007). The cumulative effect of these improvements have pushed the limits and expanded the application of fluorescence techniques to numerous scientific research fields. One of the more powerful advancements is the ability to obtain in situ fluorescence measurements of natural waters (Moore, 1994). The development of submersible fluorescence instruments has been made possible by component miniaturization and power reduction including advances in light sources technologies (light-emitting diodes, xenon lamps, ultraviolet [UV] lasers) and the compatible integration of new optical instruments with various sampling platforms (Twardowski et at., 2005 and references therein). The development of robust field sensors skirt the need for cumbersome and or time-consuming filtration techniques, the potential artifacts associated with sample storage, and coarse sampling designs by increasing spatiotemporal resolution (Chen, 1999; Robinson and Glenn, 1999). The ability to obtain rapid, high-quality, highly sensitive measurements over steep gradients has revolutionized investigations of dissolved organic matter (DOM) optical properties, thereby enabling researchers to address novel biogeochemical questions regarding colored or chromophoric DOM (CDOM). This chapter is dedicated to the origin, design, calibration, and use of in situ field fluorometers. It will serve as a review of considerations to be accounted for during the operation of fluorescence field sensors and call attention to areas of concern when making

  10. Design Engineering Development of Experimental MVC Desalination Installation (Part I)

    International Nuclear Information System (INIS)

    Geni Rina Sunaryo; Puradwi Ismu Wahyono

    2003-01-01

    The design for evaporator/condenser unit from the MVC desalination has been made in 4 modules. Each module is consisted by 29 Stainless steel tubes, where the distance between the plates is 1.7 m. Those 4 modules can be connected each other by using series or parallel which is depend on the purpose of the experiment. This design has been based on the overall calculation of the process of MVC (Mechanical Vapor Compression) desalination. The complex parameters such as desired water product flow rate, temperature distillate, boiling point, and other complex parameters has been used as inputs. From the calculation results have been found that the optimum total required surface area for laboratory scale of evaporator/condenser is 23.8 m 2 , therefore, the required pipe length with outer diameter of 16 mm and thickness of 1.2 mm are obtained as 345 m. The coefficient heat transfer for evaporating and boiling are obtained as 4.15 kWh/m 2 . o C and 4.32 kWh/m 2 . o C, respectively. Then, the evaporation and condensation coefficient are obtained as 4 kWh/m 2 . o C and 53 kWh/m 2 . o C, respectively. The required pipe length with the same diameter and thickness for distillate and brine are obtained as 24 m and 150 m, respectively. The required electricity consumption for the compressor per m 3 product is 322.85 kWh. From this optimum condition, the design of evaporator/condenser has been made. (author)

  11. Experimental burn plot trial in the Kruger National Park: history, experimental design and suggestions for data analysis

    Directory of Open Access Journals (Sweden)

    R. Biggs

    2003-12-01

    Full Text Available The experimental burn plot (EBP trial initiated in 1954 is one of few ongoing long-termfire ecology research projects in Africa. The trial aims to assess the impacts of differentfire regimes in the Kruger National Park. Recent studies on the EBPs have raised questions as to the experimental design of the trial, and the appropriate model specificationwhen analysing data. Archival documentation reveals that the original design was modified on several occasions, related to changes in the park's fire policy. These modifications include the addition of extra plots, subdivision of plots and changes in treatmentsover time, and have resulted in a design which is only partially randomised. The representativity of the trial plots has been questioned on account of their relatively small size,the concentration of herbivores on especially the frequently burnt plots, and soil variation between plots. It is suggested that these factors be included as covariates inexplanatory models or that certain plots be excluded from data analysis based on resultsof independent studies of these factors. Suggestions are provided for the specificationof the experimental design when analysing data using Analysis of Variance. It is concluded that there is no practical alternative to treating the trial as a fully randomisedcomplete block design.

  12. Analysis and experimental design of micro-pulse gun

    CERN Document Server

    Yang Xing Fan; LiuXiSan; LuHePing; Xu Zhou; Zhang Zhi Fu

    2002-01-01

    Micro-pulse gun (MPG) is a novel microwave electron gun. It is a kind of high brightness electron source. The concept of MPG has been studied in detail. The multipacting theory and self-bunching progress of the electron beam are discussed. The natural 'bunching', or resonant phase selection of the particles gives rise to high current density (kA/cm sup 2 ). The saturated beam pulse width is found to be typically 5% of the RF period. The cavity parameters such as the accelerating gap width and electric field are determined based on the theory. The cavity design and the dynamical simulation result are also presented

  13. Experimental Design for Testing Local Lorentz Invariance Violations in Gravity

    Directory of Open Access Journals (Sweden)

    Ya-Fen Chen

    2017-10-01

    Full Text Available Local Lorentz invariance is an important component of General Relativity. Testing for Local Lorentz invariance can not only probe the foundation stone of General Relativity but also help to explore the unified theory for General Relativity and quantum mechanics. In this paper, we search the Local Lorentz invariance violation associated with operators of mass dimension d = 6 in the pure-gravity sector with short-range gravitational experiments. To enlarge the Local Lorentz invariance violation signal effectively, we design a new experiment in which the constraints of all fourteen violation coefficients may be improved by about one order of magnitude.

  14. Experimental Design for Testing Local Lorentz Invariance Violations in Gravity

    Science.gov (United States)

    Chen, Ya-Fen; Tan, Yu-Jie; Shao, Cheng-Gang

    2017-09-01

    Local Lorentz invariance is an important component of General Relativity. Testing for Local Lorentz invariance can not only probe the foundation stone of General Relativity but also help to explore the unified theory for General Relativity and quantum mechanics. In this paper, we search the Local Lorentz invariance violation associated with operators of mass dimension d=6 in the pure-gravity sector with short-range gravitational experiments. To enlarge the Local Lorentz invariance violation signal effectively, we design a new experiment in which the constraints of all fourteen violation coefficients may be improved by about one order of magnitude

  15. Model-robust experimental designs for the fractional polynomial ...

    African Journals Online (AJOL)

    We can obtain the Jacobian matrices for (7) and (8) in a similar fashion as in Example. I. Assume the ranges for x1 and x2 to be [0.5,10] and the initial parameter estimates,. (β0,β1,β2,β11,β22,α1,α2) = (8.2,3.2,2.5,0,0,0.5,1.5) and γ = 0.90. A ten point locally. Dγ-optimal design is shown in Figure 1 (The areas of the solid ...

  16. The ISR Asymmetrical Capacitor Thruster: Experimental Results and Improved Designs

    Science.gov (United States)

    Canning, Francis X.; Cole, John; Campbell, Jonathan; Winet, Edwin

    2004-01-01

    A variety of Asymmetrical Capacitor Thrusters has been built and tested at the Institute for Scientific Research (ISR). The thrust produced for various voltages has been measured, along with the current flowing, both between the plates and to ground through the air (or other gas). VHF radiation due to Trichel pulses has been measured and correlated over short time scales to the current flowing through the capacitor. A series of designs were tested, which were increasingly efficient. Sharp features on the leading capacitor surface (e.g., a disk) were found to increase the thrust. Surprisingly, combining that with sharp wires on the trailing edge of the device produced the largest thrust. Tests were performed for both polarizations of the applied voltage, and for grounding one or the other capacitor plate. In general (but not always) it was found that the direction of the thrust depended on the asymmetry of the capacitor rather than on the polarization of the voltage. While no force was measured in a vacuum, some suggested design changes are given for operation in reduced pressures.

  17. Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship-Quasi-Experimental Designs.

    Science.gov (United States)

    Schweizer, Marin L; Braun, Barbara I; Milstone, Aaron M

    2016-10-01

    Quasi-experimental studies evaluate the association between an intervention and an outcome using experiments in which the intervention is not randomly assigned. Quasi-experimental studies are often used to evaluate rapid responses to outbreaks or other patient safety problems requiring prompt, nonrandomized interventions. Quasi-experimental studies can be categorized into 3 major types: interrupted time-series designs, designs with control groups, and designs without control groups. This methods paper highlights key considerations for quasi-experimental studies in healthcare epidemiology and antimicrobial stewardship, including study design and analytic approaches to avoid selection bias and other common pitfalls of quasi-experimental studies. Infect Control Hosp Epidemiol 2016;1-6.

  18. A projection method for under determined optimal experimental designs

    KAUST Repository

    Long, Quan

    2014-01-09

    A new implementation, based on the Laplace approximation, was developed in (Long, Scavino, Tempone, & Wang 2013) to accelerate the estimation of the post–experimental expected information gains in the model parameters and predictive quantities of interest. A closed–form approximation of the inner integral and the order of the corresponding dominant error term were obtained in the cases where the parameters are determined by the experiment. In this work, we extend that method to the general cases where the model parameters could not be determined completely by the data from the proposed experiments. We carry out the Laplace approximations in the directions orthogonal to the null space of the corresponding Jacobian matrix, so that the information gain (Kullback–Leibler divergence) can be reduced to an integration against the marginal density of the transformed parameters which are not determined by the experiments. Furthermore, the expected information gain can be approximated by an integration over the prior, where the integrand is a function of the projected posterior covariance matrix. To deal with the issue of dimensionality in a complex problem, we use Monte Carlo sampling or sparse quadratures for the integration over the prior probability density function, depending on the regularity of the integrand function. We demonstrate the accuracy, efficiency and robustness of the proposed method via several nonlinear under determined numerical examples.

  19. A Multifunctional Public Lighting Infrastructure, Design and Experimental Test

    Directory of Open Access Journals (Sweden)

    Marco Beccali

    2017-12-01

    Full Text Available Nowadays, the installation of efficient lighting sources and Information and Communications Technologies can provide economic benefits, energy efficiency, and visual comfort requirements. More advantages can be derived if the public lighting infrastructure integrates a smart grid. This study presents an experimental multifunctional infrastructure for public lighting, installed in Palermo. The system is able to provide smart lighting functions (hotspot Wi-Fi, video-surveillances, car and pedestrian access control, car parking monitoring and support for environmental monitoring. A remote control and monitoring platform called “Centro Servizi” processes the information coming from different installations as well as their status in real time, and sends commands to the devices (e.g. to control the luminous flux, each one provided with a machine to machine interface. Data can be reported either on the web or on a customised app. The study has shown the efficient operation of such new infrastructure and its capability to provide new functions and benefits to citizens, tourists, and public administration. Thus, this system represents a starting point for the implementation of many other lighting infrastructure features typical of a “smart city.”

  20. Improved field experimental designs and quantitative evaluation of aquatic ecosystems

    Energy Technology Data Exchange (ETDEWEB)

    McKenzie, D.H.; Thomas, J.M.

    1984-05-01

    The paired-station concept and a log transformed analysis of variance were used as methods to evaluate zooplankton density data collected during five years at an electrical generation station on Lake Michigan. To discuss the example and the field design necessary for a valid statistical analysis, considerable background is provided on the questions of selecting (1) sampling station pairs, (2) experimentwise error rates for multi-species analyses, (3) levels of Type I and II error rates, (4) procedures for conducting the field monitoring program, and (5) a discussion of the consequences of violating statistical assumptions. Details for estimating sample sizes necessary to detect changes of a specified magnitude are included. Both statistical and biological problems with monitoring programs (as now conducted) are addressed; serial correlation of successive observations in the time series obtained was identified as one principal statistical difficulty. The procedure reduces this problem to a level where statistical methods can be used confidently. 27 references, 4 figures, 2 tables.

  1. Design and experimental evaluation of flexible manipulator control algorithms

    International Nuclear Information System (INIS)

    Kwon, D.S.; Hwang, D.H.; Babcock, S.M.; Kress, R.L.

    1995-01-01

    Within the Environmental Restoration and Waste Management Program of the US Department of Energy, the remediation of single-shell radioactive waste storage tanks is one of the areas that challenge state-of-the-art equipment and methods. The use of long-reach manipulators is being seriously considered for this task. Because of high payload capacity and high length-to-cross-section ratio requirements, these long-reach manipulator systems are expected to use hydraulic actuators and to exhibit significant structural flexibility. The controller has been designed to compensate for the hydraulic actuator dynamics by using a load-compensated velocity feedforward loop and to increase the bandwidth by using an inner pressure feedback loop. Shaping filter techniques have been applied as feedforward controllers to avoid structural vibrations during operation. Various types of shaping filter methods have been investigated. Among them, a new approach, referred to as a ''feedforward simulation filter'' that uses embedded simulation, has been presented

  2. Quasi-experimental study designs series-paper 7: assessing the assumptions.

    Science.gov (United States)

    Bärnighausen, Till; Oldenburg, Catherine; Tugwell, Peter; Bommer, Christian; Ebert, Cara; Barreto, Mauricio; Djimeu, Eric; Haber, Noah; Waddington, Hugh; Rockers, Peter; Sianesi, Barbara; Bor, Jacob; Fink, Günther; Valentine, Jeffrey; Tanner, Jeffrey; Stanley, Tom; Sierra, Eduardo; Tchetgen, Eric Tchetgen; Atun, Rifat; Vollmer, Sebastian

    2017-09-01

    Quasi-experimental designs are gaining popularity in epidemiology and health systems research-in particular for the evaluation of health care practice, programs, and policy-because they allow strong causal inferences without randomized controlled experiments. We describe the concepts underlying five important quasi-experimental designs: Instrumental Variables, Regression Discontinuity, Interrupted Time Series, Fixed Effects, and Difference-in-Differences designs. We illustrate each of the designs with an example from health research. We then describe the assumptions required for each of the designs to ensure valid causal inference and discuss the tests available to examine the assumptions. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Constructing experimental designs for discrete-choice experiments: report of the ISPOR Conjoint Analysis Experimental Design Good Research Practices Task Force.

    Science.gov (United States)

    Reed Johnson, F; Lancsar, Emily; Marshall, Deborah; Kilambi, Vikram; Mühlbacher, Axel; Regier, Dean A; Bresnahan, Brian W; Kanninen, Barbara; Bridges, John F P

    2013-01-01

    Stated-preference methods are a class of evaluation techniques for studying the preferences of patients and other stakeholders. While these methods span a variety of techniques, conjoint-analysis methods-and particularly discrete-choice experiments (DCEs)-have become the most frequently applied approach in health care in recent years. Experimental design is an important stage in the development of such methods, but establishing a consensus on standards is hampered by lack of understanding of available techniques and software. This report builds on the previous ISPOR Conjoint Analysis Task Force Report: Conjoint Analysis Applications in Health-A Checklist: A Report of the ISPOR Good Research Practices for Conjoint Analysis Task Force. This report aims to assist researchers specifically in evaluating alternative approaches to experimental design, a difficult and important element of successful DCEs. While this report does not endorse any specific approach, it does provide a guide for choosing an approach that is appropriate for a particular study. In particular, it provides an overview of the role of experimental designs for the successful implementation of the DCE approach in health care studies, and it provides researchers with an introduction to constructing experimental designs on the basis of study objectives and the statistical model researchers have selected for the study. The report outlines the theoretical requirements for designs that identify choice-model preference parameters and summarizes and compares a number of available approaches for constructing experimental designs. The task-force leadership group met via bimonthly teleconferences and in person at ISPOR meetings in the United States and Europe. An international group of experimental-design experts was consulted during this process to discuss existing approaches for experimental design and to review the task force's draft reports. In addition, ISPOR members contributed to developing a consensus

  4. Adequacy of different experimental designs for eucalyptus spacing trials in Portuguese environmental conditions

    Science.gov (United States)

    Paula Soares; Margarida Tome

    2000-01-01

    In Portugal, several eucalyptus spacing trials cover a relatively broad range of experimental designs: trials with a non-randomized block design with plots of different size and number of trees per plot; trials based on a non-systematic design in which spacings were randomized resulting in a factorial arrangement with plots of different size and shape and equal number...

  5. Recent developments in optimal experimental designs for functional magnetic resonance imaging.

    Science.gov (United States)

    Kao, Ming-Hung; Temkit, M'hamed; Wong, Weng Kee

    2014-07-28

    Functional magnetic resonance imaging (fMRI) is one of the leading brain mapping technologies for studying brain activity in response to mental stimuli. For neuroimaging studies utilizing this pioneering technology, there is a great demand of high-quality experimental designs that help to collect informative data to make precise and valid inference about brain functions. This paper provides a survey on recent developments in experimental designs for fMRI studies. We briefly introduce some analytical and computational tools for obtaining good designs based on a specified design selection criterion. Research results about some commonly considered designs such as blocked designs, and m-sequences are also discussed. Moreover, we present a recently proposed new type of fMRI designs that can be constructed using a certain type of Hadamard matrices. Under certain assumptions, these designs can be shown to be statistically optimal. Some future research directions in design of fMRI experiments are also discussed.

  6. Experimental design for study of cardiopulmonary resuscitation in dogs.

    Science.gov (United States)

    Barsan, W G; Levy, R C

    1981-03-01

    Many different designs for studies of various aspects of cardiopulmonary resuscitation (CPR) in dogs are described in the literature. No single technique is generally accepted. We present a systematized approach to the study of CPR in the canine model. Cardiac output, arterial blood pressure, and electrocardiogram were recorded for three different methods. The methods studied were closed chest compression, closed chest compression with an automatic gas-powered chest compressor, and open chest manual cardiac massage. Cardiac output for both types of external chest compression were less than 17% of control in all cases. With open chest cardiac massage, systemic arterial blood pressures were in the 50 mm Hg to 100 mm Hg range and cardiac output of up to 70% of control was achieved. Using a metronome to obtain compression rate and the arterial blood pressure to guide the efficacy of compression, consistent levels of cardiac output could be achieved for up to 30 minutes using open chest cardiac massage. Closed chest massage in man results in a cardiac output of 25% to 30% of normal when performed under optimal conditions. A cardiac output of 25% to 30% of control cannot be achieved in large dogs with external chest compression, and hence is not a good model to stimulate CPR in man.

  7. Experimental design for dynamics identification of cellular processes.

    Science.gov (United States)

    Dinh, Vu; Rundell, Ann E; Buzzard, Gregery T

    2014-03-01

    We address the problem of using nonlinear models to design experiments to characterize the dynamics of cellular processes by using the approach of the Maximally Informative Next Experiment (MINE), which was introduced in W. Dong et al. (PLoS ONE 3(8):e3105, 2008) and independently in M.M. Donahue et al. (IET Syst. Biol. 4:249-262, 2010). In this approach, existing data is used to define a probability distribution on the parameters; the next measurement point is the one that yields the largest model output variance with this distribution. Building upon this approach, we introduce the Expected Dynamics Estimator (EDE), which is the expected value using this distribution of the output as a function of time. We prove the consistency of this estimator (uniform convergence to true dynamics) even when the chosen experiments cluster in a finite set of points. We extend this proof of consistency to various practical assumptions on noisy data and moderate levels of model mismatch. Through the derivation and proof, we develop a relaxed version of MINE that is more computationally tractable and robust than the original formulation. The results are illustrated with numerical examples on two nonlinear ordinary differential equation models of biomolecular and cellular processes.

  8. Design, Manufacture, and Experimental Serviceability Validation of ITER Blanket Components

    Science.gov (United States)

    Leshukov, A. Yu.; Strebkov, Yu. S.; Sviridenko, M. N.; Safronov, V. M.; Putrik, A. B.

    2017-12-01

    In 2014, the Russian Federation and the ITER International Organization signed two Procurement Arrangements (PAs) for ITER blanket components: 1.6.P1ARF.01 "Blanket First Wall" of February 14, 2014, and 1.6.P3.RF.01 "Blanket Module Connections" of December 19, 2014. The first PA stipulates development, manufacture, testing, and delivery to the ITER site of 179 Enhanced Heat Flux (EHF) First Wall (FW) Panels intended for withstanding the heat flux from the plasma up to 4.7MW/m2. Two Russian institutions, NIIEFA (Efremov Institute) and NIKIET, are responsible for the implementation of this PA. NIIEFA manufactures plasma-facing components (PFCs) of the EHF FW panels and performs the final assembly and testing of the panels, and NIKIET manufactures FW beam structures, load-bearing structures of PFCs, and all elements of the panel attachment system. As for the second PA, NIKIET is the sole official supplier of flexible blanket supports, electrical insulation key pads (EIKPs), and blanket module/vacuum vessel electrical connectors. Joint activities of NIKIET and NIIEFA for implementing PA 1.6.P1ARF.01 are briefly described, and information on implementation of PA 1.6.P3.RF.01 is given. Results of the engineering design and research efforts in the scope of the above PAs in 2015-2016 are reported, and results of developing the technology for manufacturing ITER blanket components are presented.

  9. The pulse tube engine: A numerical and experimental approach on its design, performance, and operating conditions

    International Nuclear Information System (INIS)

    Moldenhauer, Stefan; Stark, Tilman; Holtmann, Christoph; Thess, André

    2013-01-01

    The pulse tube engine is a simple heat engine based on the pulse tube process. Due to its simplicity it has a high potential to be applicable in waste heat usage and energy harvesting purposes. In this work, mathematical and experimental design tools are developed to study a pressurized laboratory scale pulse tube engine. The mathematical model is based on the transient numerical solution of the governing differential equations for mass, momentum and energy. The Modelica environment of SimulationX is used to solve the equations numerically and the model is employed to design the experimental test engine with helium as working fluid. The transient behavior of the pulse tube engine's underlying thermodynamic properties is studied numerically and experimentally under different design parameters as well as for different heat input temperatures, filling pressures and operating frequencies. The measured engine characteristics are compared with the calculated predictions. Internal and external power losses are quantified. Design studies for a further development of the pulse tube engine are performed experimentally. The developed numerical tool provides a rational framework for up-scaling the current laboratory model to industrial scale. - Highlights: • We developed a mathematical model and an experimental test engine to study the pulse tube engine. • The experimental test engine is able to operate with pressurized helium of up to 12 bar filling pressure. • We characterized and compared the engine's behavior under different design features and operating conditions. • Design studies for a further development of the pulse tube engine are performed experimentally

  10. Delineamento experimental e tamanho de amostra para alface cultivada em hidroponia Experimental design and sample size for hydroponic lettuce crop

    Directory of Open Access Journals (Sweden)

    Valéria Schimitz Marodim

    2000-10-01

    Full Text Available Este estudo visa a estabelecer o delineamento experimental e o tamanho de amostra para a cultura da alface (Lactuca sativa em hidroponia, pelo sistema NFT (Nutrient film technique. O experimento foi conduzido no Laboratório de Cultivos Sem Solo/Hidroponia, no Departamento de Fitotecnia da Universidade Federal de Santa Maria e baseou-se em dados de massa de plantas. Os resultados obtidos mostraram que, usando estrutura de cultivo de alface em hidroponia sobre bancadas de fibrocimento com seis canais, o delineamento experimental adequado é blocos ao acaso se a unidade experimental for constituída de faixas transversais aos canais das bancadas, e deve ser inteiramente casualizado se a bancada for a unidade experimental; para a variável massa de plantas, o tamanho da amostra é de 40 plantas para uma semi-amplitude do intervalo de confiança em percentagem da média (d igual a 5% e de 7 plantas para um d igual a 20%.This study was carried out to establish the experimental design and sample size for hydroponic lettuce (Lactuca sativa crop under nutrient film technique. The experiment was conducted in the Laboratory of Hydroponic Crops of the Horticulture Department of the Federal University of Santa Maria. The evaluated traits were plant weight. Under hydroponic conditions on concrete bench with six ducts, the most indicated experimental design for lettuce is randomised blocks for duct transversal plots or completely randomised for bench plot. The sample size for plant weight should be 40 and 7 plants, respectively, for a confidence interval of mean percentage (d equal to 5% and 20%.

  11. [Impacts that dimethoate inhibited the benchmark dose of acetylcholinesterase based on experimental designs].

    Science.gov (United States)

    He, Xiansong; Li, Tingting; Yi, Nannan; Wu, Hui; Zhao, Minxian; Yao, Xinya; Wang, Cannan

    2013-11-01

    To obtain the impacts of experimental design on benchmark dose (BMD), and the result was applied to test the computer simulation by software Slob (optimal method to calculate the BMD: for a certain sample capacity, to add the experimental groups by reducing the amount of animals in each group) , consequently, this method can be widely used in the future. Eighty adult female SD rats were ig given dimethoate 0.5, 1, 2, 4, 8, 16 and 32 mg/kg for 21 d, respectively. Rats were sacrificed, and acetylcholinesterase (AChE) activity in the hippocampus, cerebral cortex and serum of rats was determined after dimethoate was ig given to rats for 21 d. And then, the software package PROAST28.1 was applied to calculate the BMD. The four does groups of 10 animals (4 x 10 design) and 8 x 5 design were selected from 8 x 10 design to study the impacts of experimental design on BMD. Comparing with the normal control, the significant decline of AChE in hippocampus was observed in 2, 4, 8, 16 and 32 mg/kg groups (P design as the standard, the confidence interval of BMD calculated by both of 4 x 10 design and 8 x 5 design covered the BMD by 8 x 10 design. And also, confidence interval of BMD, calculated by design scheme 1, 2, 3, 4 and 6 of 4 x 10 design, wider than that of 8 x 5 design, but its scheme 5 narrower than 8 x 5 design. To add experimental groups in a certain sample capacity was the optimal method to calculate BMD, but was not the common toxicity experimental design (e. g. set four groups including control, low-dose, moderate-dose, high-dose group).

  12. Design, construction and testing of a radon experimental chamber; Diseno, construccion y pruebas de una camara experimental de radon

    Energy Technology Data Exchange (ETDEWEB)

    Chavez B, A.; Balcazar G, M

    1991-10-15

    To carry out studies on the radon behavior under controlled and stable conditions it was designed and constructed a system that consists of two parts: a container of mineral rich in Uranium and an experimentation chamber with radon united one to the other one by a step valve. The container of uranium mineral approximately contains 800 gr of uranium with a law of 0.28%; the radon gas emanated by the mineral is contained tightly by the container. When the valve opens up the radon gas it spreads to the radon experimental chamber; this contains 3 accesses that allow to install different types of detectors. The versatility of the system is exemplified with two experiments: 1. With the radon experimental chamber and an associated spectroscopic system, the radon and two of its decay products are identified. 2. The design of the system allows to couple the mineral container to other experimental geometries to demonstrate this fact it was coupled and proved a new automatic exchanger system of passive detectors of radon. The results of the new automatic exchanger system when it leave to flow the radon freely among the container and the automatic exchanger through a plastic membrane of 15 m. are shown. (Author)

  13. Accessibility and replacement as prime constraints in the design of large experimental tokamaks

    International Nuclear Information System (INIS)

    Challender, R.S.; Reynolds, P.

    1976-01-01

    An attempt is made to bring together those design features of large, experimental Tokamaks, which would lead to better accessibility during non-active operation and, in particular, permit replacement and repair after activation, thereby making possible an extended period of experimental operation into the ignition phase

  14. Scaffolded Instruction Improves Student Understanding of the Scientific Method & Experimental Design

    Science.gov (United States)

    D'Costa, Allison R.; Schlueter, Mark A.

    2013-01-01

    Implementation of a guided-inquiry lab in introductory biology classes, along with scaffolded instruction, improved students' understanding of the scientific method, their ability to design an experiment, and their identification of experimental variables. Pre- and postassessments from experimental versus control sections over three semesters…

  15. Establishing the experimenting society : The historical origin of social experimentation according to the randomized controlled design

    NARCIS (Netherlands)

    Dehue, T

    2001-01-01

    This article tl aces the historical origin of social experimentation. It highlights the central role of psychology in establishing the randomized controlled design and its quasi-experimental derivatives. The author investigates the differences in the 19th- and 20th-century meaning of the expression

  16. Optimization of fast disintegration tablets using pullulan as diluent by central composite experimental design

    OpenAIRE

    Patel, Dipil; Chauhan, Musharraf; Patel, Ravi; Patel, Jayvadan

    2012-01-01

    The objective of this work was to apply central composite experimental design to investigate main and interaction effect of formulation parameters in optimizing novel fast disintegration tablets formulation using pullulan as diluents. Face centered central composite experimental design was employed to optimize fast disintegration tablet formulation. The variables studied were concentration of diluents (pullulan, X1), superdisintigrant (sodium starch glycolate, X2), and direct compression aid ...

  17. Design study of the experimental multi-purpose high temperature gas-cooled reactor

    International Nuclear Information System (INIS)

    Tsunoda, Ryokichi

    1981-01-01

    In this paper, the design study carried out since 1973 is outlined. The basic conceptual design was performed in fiscal 1973. In this design, concept was established on the total system of the experimental high temperature gas-cooled reactor including heat-utilizing system. The first conceptual design was carried out in fiscal 1974. The range of design was limited to the experimental reactor and its direct heat-removing system. The part 2 of the first conceptual design was performed in fiscal 1975, and the system design concerning the plant characteristics was made. The part 1 of the adjustment design was carried out in fiscal 1976, and the subject was the adjustment design of plant systems. The part 2 was performed in fiscal 1977, and the characteristics of plant control system were analyzed. In fiscal 1978, the analysis of flow characteristics in the core was made. The integrated system design was carried out in fiscal 1979, and the design of the total plant system except heat-utilizing system was started again. The part 1 of the detailed design was performed in fiscal 1980, and in addition, the possibility of increasing power output was examined. The construction cost of the experimental reactor plant estimated in 1979 was far higher than that in 1973. (Kako, I.)

  18. The experimental design of solar heating thermoelectric generator with wind cooling chimney

    International Nuclear Information System (INIS)

    Özdemir, Ali Ekber; Köysal, Yavuz; Özbaş, Engin; Atalay, Tahsin

    2015-01-01

    Highlights: • We model an experimental design of thermal electrical generator. • Electrical parameters were collected under the solar radiation. • All the calculated values were obtained from collected data. • Generated power and electrical efficiency were changed by thermal gradient. - Abstract: In this paper we present an experimental design of new solar based thermoelectric generator with wind chimney. Presented generator mainly consists of four parts: a heat pipe with solar collector tube for solar heating, a wind chimney for cooling, a thermoelectric (TE) module for electricity generation and measurement devices-sensors. Presented generator based on experimental design. Aim of this experimental design is to show an alternative way for cheap and efficiently renewable energy producing. The most important features of presented generator are uncomplicated structure, efficiently and cheapness. This experimental design can be improved and used for domestic and commercial application. For this reason, main parts of system can be enhanced and system can be improved. To evaluate of presented generator we collected some experimental data on designed system. Then maximum output power, electrical efficiency and Seebeck coefficient are calculated from obtained data. Results of the measurement are displayed in the form of graphs and tables. Our experiment was carried out on 16th and 21th August, in Samsun, on the north coast of Turkey with the exact location 41°14′N 36°26′E with sea level. Collection of the data was performed from 8:30 a.m. to 4 p.m

  19. Theoretical and experimental analyses of optimal experimental design for determination of hydraulic conductivity of cell membrane.

    Science.gov (United States)

    Zhou, Xiaoming; Gao, Frank; Shu, Zhiquan; Chung, Jae-Hyun; Heimfeld, Shelly; Gao, Dayong

    2010-09-01

    Determination of cell hydraulic conductivity (Lp) is required to predict the optimal conditions for cell cryopreservation. One of the critical procedures associated with the determination of Lp is to measure the kinetics of cell volume change in response to a sudden cell exposure to anisosmotic media until the cells achieve an osmotic equilibrium state. To achieve accurate measurement, it should be ensured that (1) the cell osmotic equilibration process is sufficiently slow, and (2) the total cell volume change (ΔV) is much larger than the resolution of the measuring device (δ). In this article, a cell's half volume excursion time (t*) was defined as the time in which osmotically active cell water volume increases or decreases by half of its maximum change. Based on the water transport equations, a series of analytical solutions were derived. The t* and ΔV were expressed as functions of 2 control variables: initial intracellular osmolality (Mo) and extracellular osmolality (Me), and the effects of Me and Mo on t* and ΔV were predicted theoretically. The predictions were confirmed by performing experiments using two different cell types. In the light of this study, a strategy to optimize the experiment design for the Lp determination is suggested.

  20. Design studies for the transmission simulator method of experimental dynamic substructuring.

    Energy Technology Data Exchange (ETDEWEB)

    Mayes, Randall Lee; Arviso, Michael

    2010-05-01

    In recent years, a successful method for generating experimental dynamic substructures has been developed using an instrumented fixture, the transmission simulator. The transmission simulator method solves many of the problems associated with experimental substructuring. These solutions effectively address: (1) rotation and moment estimation at connection points; (2) providing substructure Ritz vectors that adequately span the connection motion space; and (3) adequately addressing multiple and continuous attachment locations. However, the transmission simulator method may fail if the transmission simulator is poorly designed. Four areas of the design addressed here are: (1) designating response sensor locations; (2) designating force input locations; (3) physical design of the transmission simulator; and (4) modal test design. In addition to the transmission simulator design investigations, a review of the theory with an example problem is presented.

  1. Development and Validation of a Rubric for Diagnosing Students' Experimental Design Knowledge and Difficulties

    Science.gov (United States)

    Dasgupta, Annwesa P.; Anderson, Trevor R.; Pelaez, Nancy

    2014-01-01

    It is essential to teach students about experimental design, as this facilitates their deeper understanding of how most biological knowledge was generated and gives them tools to perform their own investigations. Despite the importance of this area, surprisingly little is known about what students actually learn from designing biological…

  2. Scaffolding a Complex Task of Experimental Design in Chemistry with a Computer Environment

    Science.gov (United States)

    Girault, Isabelle; d'Ham, Cédric

    2014-01-01

    When solving a scientific problem through experimentation, students may have the responsibility to design the experiment. When students work in a conventional condition, with paper and pencil, the designed procedures stay at a very general level. There is a need for additional scaffolds to help the students perform this complex task. We propose a…

  3. Using a Discussion about Scientific Controversy to Teach Central Concepts in Experimental Design

    Science.gov (United States)

    Bennett, Kimberley Ann

    2015-01-01

    Students may need explicit training in informal statistical reasoning in order to design experiments or use formal statistical tests effectively. By using scientific scandals and media misinterpretation, we can explore the need for good experimental design in an informal way. This article describes the use of a paper that reviews the measles mumps…

  4. Robustness and efficiency of D-optimal experimental designs in a growth problem

    NARCIS (Netherlands)

    Paulo, M.J.; Rasch, D.

    2002-01-01

    To assess tree growth, for example in diameter, a forester typically measures the trees at regular time points. We call such designs equidistant. In this paper we look at the robustness and efficiency of several experimental designs, using the D-optimality criterion, in a case study of diameter

  5. Overview of design development of FCC-hh Experimental Interaction Regions

    CERN Document Server

    AUTHOR|(CDS)2082479; Abelleira, Jose; Cruz Alaniz, Emilia; Van Riesen-Haupt, Leon; Benedikt, Michael; Besana, Maria Ilaria; Buffat, Xavier; Burkhardt, Helmut; Cerutti, Francesco; Langner, Andy Sven; Martin, Roman; Riegler, Werner; Schulte, Daniel; Tomas Garcia, Rogelio; Appleby, Robert Barrie; Rafique, Haroon; Barranco Garcia, Javier; Pieloni, Tatiana; Boscolo, Manuela; Collamati, Francesco; Nevay, Laurence James; Hofer, Michael

    2017-01-01

    The experimental interaction region (EIR) is one of the key areas that define the performance of the Future Circular Collider. In this overview we will describe the status and the evolution of the design of EIR of FCC-hh, focusing on design of the optics, energy deposition in EIR elements, beam-beam effects and machine detector interface issues.

  6. Experimental and Theoretical Progress of Linear Collider Final Focus Design and ATF2 Facility

    CERN Document Server

    Seryi, Andrei; Zimmermann, Frank; Kubo, Kiyoshi; Kuroda, Shigeru; Okugi, Toshiyuki; Tauchi, Toshiaki; Terunuma, Nobuhiro; Urakawa, Junji; White, Glen; Woodley, Mark; Angal-Kalinin, Deepa

    2014-01-01

    In this brief overview we will reflect on the process of the design of the linear collider (LC) final focus (FF) optics, and will also describe the theoretical and experimental efforts on design and practical realisation of a prototype of the LC FF optics implemented in the ATF2 facility at KEK, Japan, presently being commissioned and operated.

  7. Visualizing Experimental Designs for Balanced ANOVA Models using Lisp-Stat

    Directory of Open Access Journals (Sweden)

    Philip W. Iversen

    2004-12-01

    Full Text Available The structure, or Hasse, diagram described by Taylor and Hilton (1981, American Statistician provides a visual display of the relationships between factors for balanced complete experimental designs. Using the Hasse diagram, rules exist for determining the appropriate linear model, ANOVA table, expected means squares, and F-tests in the case of balanced designs. This procedure has been implemented in Lisp-Stat using a software representation of the experimental design. The user can interact with the Hasse diagram to add, change, or delete factors and see the effect on the proposed analysis. The system has potential uses in teaching and consulting.

  8. Wind refrigeration : design and results of an experimental facility; Refrigeracion eolica: Diseno y resultados de una instalacion experimental

    Energy Technology Data Exchange (ETDEWEB)

    Beltran, R. G.; Talero, A.

    2004-07-01

    This article describes the experimental setup used to obtain design parameters for a wind driven refrigeration equipment. The system compressor is directly coupled to the wind mill and will provide refrigeration to a community located in La Guajira in northern Colombia. The testing on the experimental installation assessed the refrigeration capacity that could be provided by an open type commercial compressor coupled to the wind mill axis. Power and torque requirements have been evaluated for different wind mill rotational speeds. An assessment of the local conditions relating to wind speed, frequency and preferred direction for the installation site has been made based on measurements by the Meteorological National Institute and independent data from other sources. (Author)

  9. LMFBR core design codes based on experimental fast reactor 'JOYO' experiences

    International Nuclear Information System (INIS)

    Kumaoka, Yoshio; Aoki, Katsutada; Kawashima, Masatoshi.

    1982-01-01

    In order to design the core for a 1,000-MWe-class fast breeder reactor, many kinds of computer codes as design tools are needed for analyzing the multicore components, mechanical behavior, nuclear performance and the thermal hydraulic performance of the core, and for designing the fuel. To meet these needs, Toshiba has endeavored for many years to develop highly reliable computer codes for core design, some of which are described in this article, and to continue their improvement by verifying them with actual fast reactor operation data. Above all, a series of nuclear design codes named COSMOS was successfully applied to the core design of the Japanese experimental fast breeder reactor ''JOYO'', and the excellent agreement between designed values and actual measured data has concluded that Toshiba's nuclear design codes are very useful for application to future large core design. (author)

  10. Experimental designs and their recent advances in set-up, data interpretation, and analytical applications.

    Science.gov (United States)

    Dejaegher, Bieke; Heyden, Yvan Vander

    2011-09-10

    In this review, the set-up and data interpretation of experimental designs (screening, response surface, and mixture designs) are discussed. Advanced set-ups considered are the application of D-optimal and supersaturated designs as screening designs. Advanced data interpretation approaches discussed are an adaptation of the algorithm of Dong and the estimation of factor effects from supersaturated design results. Finally, some analytical applications in separation science, on the one hand, and formulation-, product-, or process optimization, on the other, are discussed. Copyright © 2011 Elsevier B.V. All rights reserved.

  11. Optimal experimental designs for dose-response studies with continuous endpoints.

    Science.gov (United States)

    Holland-Letz, Tim; Kopp-Schneider, Annette

    2015-11-01

    In most areas of clinical and preclinical research, the required sample size determines the costs and effort for any project, and thus, optimizing sample size is of primary importance. An experimental design of dose-response studies is determined by the number and choice of dose levels as well as the allocation of sample size to each level. The experimental design of toxicological studies tends to be motivated by convention. Statistical optimal design theory, however, allows the setting of experimental conditions (dose levels, measurement times, etc.) in a way which minimizes the number of required measurements and subjects to obtain the desired precision of the results. While the general theory is well established, the mathematical complexity of the problem so far prevents widespread use of these techniques in practical studies. The paper explains the concepts of statistical optimal design theory with a minimum of mathematical terminology and uses these concepts to generate concrete usable D-optimal experimental designs for dose-response studies on the basis of three common dose-response functions in toxicology: log-logistic, log-normal and Weibull functions with four parameters each. The resulting designs usually require control plus only three dose levels and are quite intuitively plausible. The optimal designs are compared to traditional designs such as the typical setup of cytotoxicity studies for 96-well plates. As the optimal design depends on prior estimates of the dose-response function parameters, it is shown what loss of efficiency occurs if the parameters for design determination are misspecified, and how Bayes optimal designs can improve the situation.

  12. The application of experimental design models in order to optimize the synthesis of geopolymers

    Directory of Open Access Journals (Sweden)

    Kioupis Dimitris

    2018-01-01

    Full Text Available The aim of this work is to propose the methodology and the mathematical tools for the design and development of geopolymeric materials from industrial wastes and by-products. The applied methodology follows the Taguchi fractional experimental design allowing the investigation of the combining effect of selected parameters in the response of the experimental system by conducting the minimum number of experiments. Two cases of geopolymer synthesis optimization based on the mechanical strength and the apparent density of the products, to which the Taguchi methodology has been successfully applied, are presented in the paper.

  13. Experimental Design and Data collection of a finishing end milling operation of AISI 1045 steel.

    Science.gov (United States)

    Dias Lopes, Luiz Gustavo; de Brito, Tarcísio Gonçalves; de Paiva, Anderson Paulo; Peruchi, Rogério Santana; Balestrassi, Pedro Paulo

    2016-03-01

    In this Data in Brief paper, a central composite experimental design was planned to collect the surface roughness of an end milling operation of AISI 1045 steel. The surface roughness values are supposed to suffer some kind of variation due to the action of several factors. The main objective here was to present a multivariate experimental design and data collection including control factors, noise factors, and two correlated responses, capable of achieving a reduced surface roughness with minimal variance. Lopes et al. (2016) [1], for example, explores the influence of noise factors on the process performance.

  14. Experimental designs for evaluation of genetic variability and selection of ancient grapevine varieties: a simulation study.

    Science.gov (United States)

    Gonçalves, E; St Aubyn, A; Martins, A

    2010-06-01

    Classical methodologies for grapevine selection used in the vine-growing world are generally based on comparisons among a small number of clones. This does not take advantage of the entire genetic variability within ancient varieties, and therefore limits selection challenges. Using the general principles of plant breeding and of quantitative genetics, we propose new breeding strategies, focussed on conservation and quantification of genetic variability by performing a cycle of mass genotypic selection prior to clonal selection. To exploit a sufficiently large amount of genetic variability, initial selection trials must be generally very large. The use of experimental designs adequate for those field trials has been intensively recommended for numerous species. However, their use in initial trials of grapevines has not been studied. With the aim of identifying the most suitable experimental designs for quantification of genetic variability and selection of ancient varieties, a study was carried out to assess through simulation the comparative efficiency of various experimental designs (randomized complete block design, alpha design and row-column (RC) design). The results indicated a greater efficiency for alpha and RC designs, enabling more precise estimates of genotypic variance, greater precision in the prediction of genetic gain and consequently greater efficiency in genotypic mass selection.

  15. Tasks related to increase of RA reactor exploitation and experimental potential, 03. Crane for handling the vertical experimental channels of the RA reactor - design project

    International Nuclear Information System (INIS)

    Pavicevic, M.

    1963-07-01

    Within the work related to improvement of experimental potential of the RA reactor, this document describes the design project of the new crane for handling the vertical experimental channels of the RA reactor, engineering drawings of the crane main elements, mechanical part, design project of the electrical part of the crane and cost estimation

  16. Conceptual design of superconducting magnet systems for the Argonne Tokamak Experimental Power Reactor

    International Nuclear Information System (INIS)

    Wang, S.T.; Turner, L.R.; Mills, F.E.; DeMichele, D.W.; Smelser, P.; Kim, S.H.

    1976-01-01

    As an integral effort in the Argonne Tokamak Experimental Power Reactor Conceptual Design, the conceptual design of a 10-tesla, pure-tension superconducting toroidal-field (TF) coil system has been developed in sufficient detail to define a realistic design for the TF coil system that could be built based upon the current state of technology with minimum technological extrapolations. A conceptual design study on the superconducting ohmic-heating (OH) coils and the superconducting equilibrium-field (EF) coils were also completed. These conceptual designs are developed in sufficient detail with clear information on high current ac conductor design, cooling, venting provision, coil structural support and zero loss poloidal coil cryostat design. Also investigated is the EF penetration into the blanket and shield

  17. Cooperative Experimental System Development - cooperative techniques beyound initial design and analysis

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Kyng, Morten; Mogensen, Preben Holst

    1995-01-01

    , however, not limited to this development context, it may be applied for in-house or contract development as well. In system development, particularly in cooperative and experimental system development, we argue that it is necessary to analytically separate the abstract concerns, e.g. analysis, design......This chapter represents a step towards the establishment of a new system development approach, called Cooperative Experimental System Development (CESD). CESD seeks to overcome a number of limitations in existing approaches: specification oriented methods usually assume that system design can...... be based solely on observation and detached reflection; prototyping methods often have a narrow focus on the technical construction of various kinds of prototypes; Participatory Design techniques—including the Scandinavian Cooperative Design (CD) approaches—seldom go beyond the early analysis...

  18. Accessibility and replacement as prime constraints in the design of large experimental Tokamaks

    International Nuclear Information System (INIS)

    Challender, R.S.; Reynolds, P.

    1976-01-01

    Many of the designs being developed for large Tokamak experiments are based on the classical geometry of the small machines in laboratories throughout the world: a circular array of coils interlinked by an inner toroidal vessel. An attempt is made to bring together those design features which would lead to better accessibility during non-active operation and in particular permit replacement and repair after activation, thereby making possible an extended period of experimental operation into the ignition phase

  19. Experimental Analyses for The Mechanical Behavior of Pressed All-Ceramic Molar Crowns with Anatomical Design

    OpenAIRE

    Porojan Liliana; Porojan Sorin; Rusu Lucian; Boloş Adrian; Savencu Cristina

    2017-01-01

    Ceramic restorations show considerable variation in strength and structural reliability regarding to the type of material, and design characteristics. The fracture of ceramics occurs with little or no plastic deformation, with cracks propagated in an unstable manner under applied tensile stresses. The aim of the study was to assess experimental analyses of pressed monolithic ceramic crowns with anatomical design used in the posterior areas in order to understand their mechanical behavior befo...

  20. Incorporating nonoverlap indices with visual analysis for quantifying intervention effectiveness in single-case experimental designs.

    Science.gov (United States)

    Brossart, Daniel F; Vannest, Kimberly J; Davis, John L; Patience, Marc A

    2014-01-01

    The field of neuropsychological rehabilitation frequently employs single case experimental designs (SCED) in research, but few if any, of the published studies use the effect sizes recommended by the American Psychological Association. Among the available methods for analysing single case designs, this paper focuses on nonoverlap methods. This paper provides examples and suggestions for integrating visual and statistical analysis, pointing out where contradictions may occur and how to be a critical consumer.

  1. Structural and compositional features of high-rise buildings: experimental design in Yekaterinburg

    Science.gov (United States)

    Yankovskaya, Yulia; Lobanov, Yuriy; Temnov, Vladimir

    2018-03-01

    The study looks at the specifics of high-rise development in Yekaterinburg. High-rise buildings are considered in the context of their historical development, structural features, compositional and imaginative design techniques. Experience of Yekaterinburg architects in experimental design is considered and analyzed. Main issues and prospects of high-rise development within the Yekaterinburg structure are studied. The most interesting and significant conceptual approaches to the structural and compositional arrangement of high-rise buildings are discussed.

  2. Experimental Design of a UCAV-Based High-Energy Laser Weapon

    Science.gov (United States)

    2016-12-01

    states that low power lasers “can provide the capability to ‘ dazzle ’ snipers and the operators of small surface ship threats, as well as blind visible...DESIGN OF A UCAV-BASED HIGH- ENERGY LASER WEAPON by Antonios Lionis December 2016 Thesis Advisor: Keith R. Cohn Co-Advisor: Eugene Paulo...COVERED Master’s thesis 4. TITLE AND SUBTITLE EXPERIMENTAL DESIGN OF A UCAV-BASED HIGH- ENERGY LASER WEAPON 5. FUNDING NUMBERS 6. AUTHOR(S

  3. Experimental Design for Hanford Low-Activity Waste Glasses with High Waste Loading

    International Nuclear Information System (INIS)

    Piepel, Gregory F.; Cooley, Scott K.; Vienna, John D.; Crum, Jarrod V.

    2015-01-01

    This report discusses the development of an experimental design for the initial phase of the Hanford low-activity waste (LAW) enhanced glass study. This report is based on a manuscript written for an applied statistics journal. Appendices A, B, and E include additional information relevant to the LAW enhanced glass experimental design that is not included in the journal manuscript. The glass composition experimental region is defined by single-component constraints (SCCs), linear multiple-component constraints (MCCs), and a nonlinear MCC involving 15 LAW glass components. Traditional methods and software for designing constrained mixture experiments with SCCs and linear MCCs are not directly applicable because of the nonlinear MCC. A modification of existing methodology to account for the nonlinear MCC was developed and is described in this report. One of the glass components, SO 3 , has a solubility limit in glass that depends on the composition of the balance of the glass. A goal was to design the experiment so that SO 3 would not exceed its predicted solubility limit for any of the experimental glasses. The SO 3 solubility limit had previously been modeled by a partial quadratic mixture model expressed in the relative proportions of the 14 other components. The partial quadratic mixture model was used to construct a nonlinear MCC in terms of all 15 components. In addition, there were SCCs and linear MCCs. This report describes how a layered design was generated to (i) account for the SCCs, linear MCCs, and nonlinear MCC and (ii) meet the goals of the study. A layered design consists of points on an outer layer, and inner layer, and a center point. There were 18 outer-layer glasses chosen using optimal experimental design software to augment 147 existing glass compositions that were within the LAW glass composition experimental region. Then 13 inner-layer glasses were chosen with the software to augment the existing and outer-layer glasses. The experimental

  4. Experimental Design for Hanford Low-Activity Waste Glasses with High Waste Loading

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Cooley, Scott K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Vienna, John D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Crum, Jarrod V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-07-24

    This report discusses the development of an experimental design for the initial phase of the Hanford low-activity waste (LAW) enhanced glass study. This report is based on a manuscript written for an applied statistics journal. Appendices A, B, and E include additional information relevant to the LAW enhanced glass experimental design that is not included in the journal manuscript. The glass composition experimental region is defined by single-component constraints (SCCs), linear multiple-component constraints (MCCs), and a nonlinear MCC involving 15 LAW glass components. Traditional methods and software for designing constrained mixture experiments with SCCs and linear MCCs are not directly applicable because of the nonlinear MCC. A modification of existing methodology to account for the nonlinear MCC was developed and is described in this report. One of the glass components, SO3, has a solubility limit in glass that depends on the composition of the balance of the glass. A goal was to design the experiment so that SO3 would not exceed its predicted solubility limit for any of the experimental glasses. The SO3 solubility limit had previously been modeled by a partial quadratic mixture model expressed in the relative proportions of the 14 other components. The partial quadratic mixture model was used to construct a nonlinear MCC in terms of all 15 components. In addition, there were SCCs and linear MCCs. This report describes how a layered design was generated to (i) account for the SCCs, linear MCCs, and nonlinear MCC and (ii) meet the goals of the study. A layered design consists of points on an outer layer, and inner layer, and a center point. There were 18 outer-layer glasses chosen using optimal experimental design software to augment 147 existing glass compositions that were within the LAW glass composition experimental region. Then 13 inner-layer glasses were chosen with the software to augment the existing and outer

  5. Selecting and Improving Quasi-Experimental Designs in Effectiveness and Implementation Research.

    Science.gov (United States)

    Handley, Margaret A; Lyles, Courtney R; McCulloch, Charles; Cattamanchi, Adithya

    2018-04-01

    Interventional researchers face many design challenges when assessing intervention implementation in real-world settings. Intervention implementation requires holding fast on internal validity needs while incorporating external validity considerations (such as uptake by diverse subpopulations, acceptability, cost, and sustainability). Quasi-experimental designs (QEDs) are increasingly employed to achieve a balance between internal and external validity. Although these designs are often referred to and summarized in terms of logistical benefits, there is still uncertainty about (a) selecting from among various QEDs and (b) developing strategies to strengthen the internal and external validity of QEDs. We focus here on commonly used QEDs (prepost designs with nonequivalent control groups, interrupted time series, and stepped-wedge designs) and discuss several variants that maximize internal and external validity at the design, execution and implementation, and analysis stages.

  6. Outline of the reactor core and internal structure design of the experimental VHTR

    International Nuclear Information System (INIS)

    Ide, Akira; Saitoh, Yoshihiro; Miki, Toshiya; Takigawa, Noboru; Nakata, Tetsuo.

    1986-01-01

    This paper outlines the reactor design of the experimental VHTR in ''The Design of Main Equipment of the Second Stage Detailed Design''. The design, being carried out between April 1985 and February 1986 under a contract with JAERI, were the summarizing one of the experimental reactor design using the pin-in-block fuel element, which was started in 1969. The basic plant design of the rationalized reactor with the thermal output of 50MW and the core outlet gas temperature of 950 deg C (initially 850 deg C) was carried out and, in this report, the reactor design and its performances are described. It became clear that the mean core power density of 2.5 W/cc and the mean fuel burn-up of 15 GWD/T will be attained using the up-graded fuel element, the sophisticated control rod layout, and so on. These figures are greater by about 70 % compared with those in the previous design. (author)

  7. International Thermonuclear Experimental Reactor (ITER). Engineering Design Activities (EDA). Agreement and protocol 1

    International Nuclear Information System (INIS)

    1992-01-01

    This document contains protocol 1 to the agreement among the European Atomic Energy Community, the government of Japan, the Government of the Russian Federation, and the Government of the United States of America on cooperation in the engineering design activities for the International Thermonuclear Experimental Reactor, which activities shall be conducted under the auspices of the International Atomic Energy Agency

  8. Digital learning material for experimental design and model building in molecular biology

    NARCIS (Netherlands)

    Aegerter-Wilmsen, T.

    2005-01-01

    Designing experimental approaches is a major cognitive skill in molecular biology research, and building models, including quantitative ones, is a cognitive skill which is rapidly gaining importance. Since molecular biology education at university level is aimed at educating future researchers, we

  9. Whither Instructional Design and Teacher Training? The Need for Experimental Research

    Science.gov (United States)

    Gropper, George L.

    2015-01-01

    This article takes a contrarian position: an "instructional design" or "teacher training" model, because of the sheer number of its interconnected parameters, is too complex to assess or to compare with other models. Models may not be the way to go just yet. This article recommends instead prior experimental research on limited…

  10. Combined application of mixture experimental design and artificial neural networks in the solid dispersion development.

    Science.gov (United States)

    Medarević, Djordje P; Kleinebudde, Peter; Djuriš, Jelena; Djurić, Zorica; Ibrić, Svetlana

    2016-01-01

    This study for the first time demonstrates combined application of mixture experimental design and artificial neural networks (ANNs) in the solid dispersions (SDs) development. Ternary carbamazepine-Soluplus®-poloxamer 188 SDs were prepared by solvent casting method to improve carbamazepine dissolution rate. The influence of the composition of prepared SDs on carbamazepine dissolution rate was evaluated using d-optimal mixture experimental design and multilayer perceptron ANNs. Physicochemical characterization proved the presence of the most stable carbamazepine polymorph III within the SD matrix. Ternary carbamazepine-Soluplus®-poloxamer 188 SDs significantly improved carbamazepine dissolution rate compared to pure drug. Models developed by ANNs and mixture experimental design well described the relationship between proportions of SD components and percentage of carbamazepine released after 10 (Q10) and 20 (Q20) min, wherein ANN model exhibit better predictability on test data set. Proportions of carbamazepine and poloxamer 188 exhibited the highest influence on carbamazepine release rate. The highest carbamazepine release rate was observed for SDs with the lowest proportions of carbamazepine and the highest proportions of poloxamer 188. ANNs and mixture experimental design can be used as powerful data modeling tools in the systematic development of SDs. Taking into account advantages and disadvantages of both techniques, their combined application should be encouraged.

  11. Development of the Neuron Assessment for Measuring Biology Students' Use of Experimental Design Concepts and Representations

    Science.gov (United States)

    Dasgupta, Annwesa P.; Anderson, Trevor R.; Pelaez, Nancy J.

    2016-01-01

    Researchers, instructors, and funding bodies in biology education are unanimous about the importance of developing students' competence in experimental design. Despite this, only limited measures are available for assessing such competence development, especially in the areas of molecular and cellular biology. Also, existing assessments do not…

  12. Trade-offs in experimental designs for estimating post-release mortality in containment studies

    Science.gov (United States)

    Rogers, Mark W.; Barbour, Andrew B; Wilson, Kyle L

    2014-01-01

    Estimates of post-release mortality (PRM) facilitate accounting for unintended deaths from fishery activities and contribute to development of fishery regulations and harvest quotas. The most popular method for estimating PRM employs containers for comparing control and treatment fish, yet guidance for experimental design of PRM studies with containers is lacking. We used simulations to evaluate trade-offs in the number of containers (replicates) employed versus the number of fish-per container when estimating tagging mortality. We also investigated effects of control fish survival and how among container variation in survival affects the ability to detect additive mortality. Simulations revealed that high experimental effort was required when: (1) additive treatment mortality was small, (2) control fish mortality was non-negligible, and (3) among container variability in control fish mortality exceeded 10% of the mean. We provided programming code to allow investigators to compare alternative designs for their individual scenarios and expose trade-offs among experimental design options. Results from our simulations and simulation code will help investigators develop efficient PRM experimental designs for precise mortality assessment.

  13. Assessing longleaf pine (Pinus palustris) restoration after southern pine beetle kill using a compact experimental design

    Science.gov (United States)

    J.-P. Berrill; C.M. Dagley

    2010-01-01

    A compact experimental design and analysis is presented of longleaf pine (Pinus palustris) survival and growth in a restoration project in the Piedmont region of Georgia, USA. Longleaf pine seedlings were planted after salvage logging and broadcast burning in areas of catastrophic southern pine beetle (Dendroctonus frontalis) attacks on even-aged mixed pine-hardwood...

  14. Guided Inquiry in a Biochemistry Laboratory Course Improves Experimental Design Ability

    Science.gov (United States)

    Goodey, Nina M.; Talgar, Cigdem P.

    2016-01-01

    Many biochemistry laboratory courses expose students to laboratory techniques through pre-determined experiments in which students follow stepwise protocols provided by the instructor. This approach fails to provide students with sufficient opportunities to practice experimental design and critical thinking. Ten inquiry modules were created for a…

  15. Factorial experimental design intended for the optimization of the alumina purification conditions

    Science.gov (United States)

    Brahmi, Mounaouer; Ba, Mohamedou; Hidri, Yassine; Hassen, Abdennaceur

    2018-04-01

    The objective of this study was to determine the optimal conditions by using the experimental design methodology for the removal of some impurities associated with the alumina. So, three alumina qualities of different origins were investigated under the same conditions. The application of full-factorial designs on the samples of different qualities of alumina has followed the removal rates of the sodium oxide. However, a factorial experimental design was developed to describe the elimination of sodium oxide associated with the alumina. The experimental results showed that chemical analyze followed by XRF prior treatment of the samples, provided a primary idea concerning these prevailing impurities. Therefore, it appeared that the sodium oxide constituted the largest amount among all impurities. After the application of experimental design, analysis of the effectors different factors and their interactions showed that to have a better result, we should reduce the alumina quantity investigated and by against increase the stirring time for the first two samples, whereas, it was necessary to increase the alumina quantity in the case of the third sample. To expand and improve this research, we should take into account all existing impurities, since we found during this investigation that the levels of partial impurities increased after the treatment.

  16. Return to Our Roots: Raising Radishes to Teach Experimental Design. Methods and Techniques.

    Science.gov (United States)

    Stallings, William M.

    1993-01-01

    Reviews research in teaching applied statistics. Concludes that students should analyze data from studies they have designed and conducted. Describes an activity in which students study germination and growth of radish seeds. Includes a table providing student instructions for both the experimental procedure and data analysis. (CFR)

  17. modelling of directed evolution: Implications for experimental design and stepwise evolution

    OpenAIRE

    Wedge , David C.; Rowe , William; Kell , Douglas B.; Knowles , Joshua

    2009-01-01

    In silico modelling of directed evolution: Implications for experimental design and stepwise evolution correspondence: Corresponding author. Tel.: +441613065145. (Wedge, David C.) (Wedge, David C.) Manchester Interdisciplinary Biocentre, University of Manchester - 131 Princess Street--> , Manchester--> , M1 7ND--> - UNITED KINGDOM (Wedge, David C.) UNITED KINGDOM (Wedge, David C.) Man...

  18. design and experimental study of a solar system for heating water ...

    African Journals Online (AJOL)

    M. Ghodbane, B. Boumeddane, N. Said

    2016-09-01

    Sep 1, 2016 ... This work presents a design and an experimental study of a linear Fresnel reflector solar with trapezoidal cavity. ... concentrator in the solar fields allocated to the domestics and industrial water-heaters. Keywords: ...... integrated photovoltaic panels, Journal of Solar Energy Engineering, Transactions of the ...

  19. Guided-Inquiry Labs Using Bean Beetles for Teaching the Scientific Method & Experimental Design

    Science.gov (United States)

    Schlueter, Mark A.; D'Costa, Allison R.

    2013-01-01

    Guided-inquiry lab activities with bean beetles ("Callosobruchus maculatus") teach students how to develop hypotheses, design experiments, identify experimental variables, collect and interpret data, and formulate conclusions. These activities provide students with real hands-on experiences and skills that reinforce their understanding of the…

  20. A Course on Experimental Design for Different University Specialties: Experiences and Changes over a Decade

    Science.gov (United States)

    Martinez Luaces, Victor; Velazquez, Blanca; Dee, Valerie

    2009-01-01

    We analyse the origin and development of an Experimental Design course which has been taught in several faculties of the Universidad de la Republica and other institutions in Uruguay, over a 10-year period. At the end of the course, students were assessed by carrying out individual work projects on real-life problems, which was innovative for…

  1. Optimization of the synthesis of 1-allyloxy-2-hydroxy-propyl-starch through statistical experimental design

    NARCIS (Netherlands)

    Huijbrechts, A.M.L.; Vermonden, T.; Bogaert, P.; Franssen, M.C.R.; Visser, G.M.; Boeriu, C.G.; Sudhölter, E.J.R.

    2009-01-01

    The synthesis of 1-allyloxy-2-hydroxy-propyl starches was studied using a statistical experimental design approach. The etherification of two different granular maize starches with allyl glycidyl ether (AGE) in a heterogeneous alkaline suspension was investigated. The optimal reaction conditions

  2. Transforming the Organic Chemistry Lab Experience: Design, Implementation, and Evaluation of Reformed Experimental Activities--REActivities

    Science.gov (United States)

    Collison, Christina G.; Kim, Thomas; Cody, Jeremy; Anderson, Jason; Edelbach, Brian; Marmor, William; Kipsang, Rodgers; Ayotte, Charles; Saviola, Daniel; Niziol, Justin

    2018-01-01

    Reformed experimental activities (REActivities) are an innovative approach to the delivery of the traditional material in an undergraduate organic chemistry laboratory. A description of the design and implementation of REActivities at both a four- and two-year institution is discussed. The results obtained using a reformed teaching observational…

  3. Conceptual design study of quasi-steady state fusion experimental reactor (FEQ-Q), part 1

    International Nuclear Information System (INIS)

    1985-12-01

    Since 1980 the design study has been conducted at JAERI for the Fusion Experimental Reactor (FER) which has been proposed to be the next machine to JT-60 in the Japanese long term program of fusion reactor development. Starting from 1984 JER design is being reviewed and redesigned. This report is a part of the interim report which describes the results obtained in the review and redesign activities in FY 1984. The results of the following design items are included; core plasma, reactor structure, reactor core components, magnets. (author)

  4. Design and Experimental Research on Venting Device for Cryostat System of EAST

    International Nuclear Information System (INIS)

    Sheng Daolin; Wu Songtao; Zhu Yinfeng

    2010-01-01

    In order to protect the cryostat system of EAST under overpressure condition,the overpressure venting device with bursting disc was designed on the cryostat system, then its type and the parameters were decided based on the ANSYS structure analysis. Furthermore, the 316LN bursting disc device was trial-manufactured based on the analytic results, and the feasibility and reliability of the design were verified through experiments. The experimental results indicate that the design is reasonable and can provide a valuable reference for the protection and research of the similar overpressure venting devices. (authors)

  5. Conceptual design study of quasi-steady state fusion experimental reactor (FER-Q), part 2

    International Nuclear Information System (INIS)

    1985-12-01

    Since 1980 the design study has been conducted at JAERI for the Fusion Experimental Reactor (FER) which has been proposed to be the next machine to JT-60 in the Japanese long term program of fusion reactor development. Starting from 1984 FER design is being reviewed and redesigned. This report is a part of the interim report which describes the results obtained in the review and redesign activities in FY 1984. The results of the following design items are included: heating/current drive system, plasma position control, power supply, diagnostics, neutronics, blanket test module, repair and maintenance and safety. (author)

  6. Determination of hydroxy acids in cosmetics by chemometric experimental design and cyclodextrin-modified capillary electrophoresis.

    Science.gov (United States)

    Liu, Pei-Yu; Lin, Yi-Hui; Feng, Chia Hsien; Chen, Yen-Ling

    2012-10-01

    A CD-modified CE method was established for quantitative determination of seven hydroxy acids in cosmetic products. This method involved chemometric experimental design aspects, including fractional factorial design and central composite design. Chemometric experimental design was used to enhance the method's separation capability and to explore the interactions between parameters. Compared to the traditional investigation that uses multiple parameters, the method that used chemometric experimental design was less time-consuming and lower in cost. In this study, the influences of three experimental variables (phosphate concentration, surfactant concentration, and methanol percentage) on the experimental response were investigated by applying a chromatographic resolution statistic function. The optimized conditions were as follows: a running buffer of 150 mM phosphate solution (pH 7) containing 0.5 mM CTAB, 3 mM γ-CD, and 25% methanol; 20 s sample injection at 0.5 psi; a separation voltage of -15 kV; temperature was set at 25°C; and UV detection at 200 nm. The seven hydroxy acids were well separated in less than 10 min. The LOD (S/N = 3) was 625 nM for both salicylic acid and mandelic acid. The correlation coefficient of the regression curve was greater than 0.998. The RSD and relative error values were all less than 9.21%. After optimization and validation, this simple and rapid analysis method was considered to be established and was successfully applied to several commercial cosmetic products. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Design, Simulation and Experimental Investigation of a Solar System Based on PV Panels and PVT Collectors

    Directory of Open Access Journals (Sweden)

    Annamaria Buonomano

    2016-06-01

    Full Text Available This paper presents numerical and experimental analyses aimed at evaluating the technical and economic feasibility of photovoltaic/thermal (PVT collectors. An experimental setup was purposely designed and constructed in order to compare the electrical performance of a PVT solar field with the one achieved by an identical solar field consisting of conventional photovoltaic (PV panels. The experimental analysis also aims at evaluating the potential advantages of PVT vs. PV in terms of enhancement of electrical efficiency and thermal energy production. The installed experimental set-up includes four flat polycrystalline silicon PV panels and four flat unglazed polycrystalline silicon PVT collectors. The total electrical power and area of the solar field are 2 kWe and 13 m2, respectively. The experimental set-up is currently installed at the company AV Project Ltd., located in Avellino (Italy. This study also analyzes the system from a numerical point of view, including a thermo-economic dynamic simulation model for the design and the assessment of energy performance and economic profitability of the solar systems consisting of glazed PVT and PV collectors. The experimental setup was modelled and partly simulated in TRNSYS environment. The simulation model was useful to analyze efficiencies and temperatures reached by such solar technologies, by taking into account the reference technology of PVTs (consisting of glazed collectors as well as to compare the numerical data obtained by dynamic simulations with the gathered experimental results for the PV technology. The numerical analysis shows that the PVT global efficiency is about 26%. Conversely, from the experimental point of view, the average thermal efficiency of PVT collectors is around 13% and the electrical efficiencies of both technologies are almost coincident and equal to 15%.

  8. Highly Efficient Design-of-Experiments Methods for Combining CFD Analysis and Experimental Data

    Science.gov (United States)

    Anderson, Bernhard H.; Haller, Harold S.

    2009-01-01

    It is the purpose of this study to examine the impact of "highly efficient" Design-of-Experiments (DOE) methods for combining sets of CFD generated analysis data with smaller sets of Experimental test data in order to accurately predict performance results where experimental test data were not obtained. The study examines the impact of micro-ramp flow control on the shock wave boundary layer (SWBL) interaction where a complete paired set of data exist from both CFD analysis and Experimental measurements By combining the complete set of CFD analysis data composed of fifteen (15) cases with a smaller subset of experimental test data containing four/five (4/5) cases, compound data sets (CFD/EXP) were generated which allows the prediction of the complete set of Experimental results No statistical difference were found to exist between the combined (CFD/EXP) generated data sets and the complete Experimental data set composed of fifteen (15) cases. The same optimal micro-ramp configuration was obtained using the (CFD/EXP) generated data as obtained with the complete set of Experimental data, and the DOE response surfaces generated by the two data sets were also not statistically different.

  9. Integration of computational modeling and experimental techniques to design fuel surrogates

    DEFF Research Database (Denmark)

    Choudhury, H.A.; Intikhab, S.; Kalakul, Sawitree

    2017-01-01

    Virtual Process-Product Design Laboratory (VPPD-Lab) are applied onto the defined compositions of the surrogate gasoline. The aim is to primarily verify the defined composition of gasoline by means of VPPD-Lab. ρ, η and RVP are calculated with more accuracy and constraints such as distillation curve...... and flash point on the blend design are also considered. A post-design experiment-based verification step is proposed to further improve and fine-tune the “best” selected gasoline blends following the computation work. Here, advanced experimental techniques are used to measure the RVP, ρ, η, RON...... and distillation temperatures. The experimental results are compared with the model predictions as well as the extended calculations in VPPD-Lab....

  10. Statistical experimental designs for the production of secondary metabolites in plant cell suspension cultures.

    Science.gov (United States)

    Schmitz, Christian; Fritsch, Leonie; Fischer, Rainer; Schillberg, Stefan; Rasche, Stefan

    2016-12-01

    Statistical experimental designs, also known as the "design of experiments" (DoE) approach, are widely used to improve not only technical processes but also to answer questions in the agricultural, medical and social sciences. Although many articles have been published about the application of DoE in these fields, few studies have addressed the use of DoE in the plant sciences, particularly in the context of plant cell suspension cultures (PCSCs). Compounds derived from PCSCs can be developed as pharmaceuticals, chemical feedstocks and cosmetic ingredients, and statistical experimental designs can be used to improve the productivity of the cells and the yield and/or quality of the target compounds in a cost efficient manner. In this article, we summarize recent findings concerning the application of statistical approaches to improve the performance of PCSCs and discuss the potential future applications of this approach.

  11. Fertilizer Response Curves for Commercial Southern Forest Species Defined with an Un-Replicated Experimental Design.

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, Mark; Aubrey, Doug; Coyle, David, R.; Daniels, Richard, F.

    2005-11-01

    There has been recent interest in use of non-replicated regression experimental designs in forestry, as the need for replication in experimental design is burdensome on limited research budgets. We wanted to determine the interacting effects of soil moisture and nutrient availability on the production of various southeastern forest trees (two clones of Populus deltoides, open pollinated Platanus occidentalis, Liquidambar styraciflua and Pinus taeda). Additionally, we required an understanding of the fertilizer response curve. To accomplish both objectives we developed a composite design that includes a core ANOVA approach to consider treatment interactions, with the addition of non-replicated regression plots receiving a range of fertilizer levels for the primary irrigation treatment.

  12. Thermoelastic Femoral Stress Imaging for Experimental Evaluation of Hip Prosthesis Design

    Science.gov (United States)

    Hyodo, Koji; Inomoto, Masayoshi; Ma, Wenxiao; Miyakawa, Syunpei; Tateishi, Tetsuya

    An experimental system using the thermoelastic stress analysis method and a synthetic femur was utilized to perform reliable and convenient mechanical biocompatibility evaluation of hip prosthesis design. Unlike the conventional technique, the unique advantage of the thermoelastic stress analysis method is its ability to image whole-surface stress (Δ(σ1+σ2)) distribution in specimens. The mechanical properties of synthetic femurs agreed well with those of cadaveric femurs with little variability between specimens. We applied this experimental system for stress distribution visualization of the intact femur, and the femurs implanted with an artificial joint. The surface stress distribution of the femurs sensitively reflected the prosthesis design and the contact condition between the stem and the bone. By analyzing the relationship between the stress distribution and the clinical results of the artificial joint, this technique can be used in mechanical biocompatibility evaluation and pre-clinical performance prediction of new artificial joint design.

  13. Single-case experimental designs to assess intervention effectiveness in rehabilitation: A practical guide.

    Science.gov (United States)

    Krasny-Pacini, Agata; Evans, Jonathan

    2017-12-15

    Single-case experimental designs (SCED) are experimental designs aiming at testing the effect of an intervention using a small number of patients (typically one to three), using repeated measurements, sequential (±randomized) introduction of an intervention and method-specific data analysis, including visual analysis and specific statistics. The aim of this paper is to familiarise professionals working in different fields of rehabilitation with SCEDs and provide practical advice on how to design and implement a SCED in clinical rehabilitation practice. Research questions suitable for SCEDs and the different types of SCEDs (e.g., alternating treatment designs, introduction/withdrawal designs and multiple baseline designs) are reviewed. Practical steps in preparing a SCED design are outlined. Examples from different rehabilitation domains are provided throughout the paper. Challenging issues such as the choice of the repeated measure, assessment of generalisation, randomization, procedural fidelity, replication and generalizability of findings are discussed. Simple rules and resources for data analysis are presented. The utility of SCEDs in physical and rehabilitation medicine (PRM) are discussed. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  14. D-OPTIMAL EXPERIMENTAL DESIGNS TO TEST FOR DEPARTURE FROM ADDITIVITY IN A FIXED-RATIO MIXTURE RAY.

    Science.gov (United States)

    Humans are exposed to mixtures of environmental compounds. A regulatory assumption is that the mixtures of chemicals act in an additive manner. However, this assumption requires experimental validation. Traditional experimental designs (full factorial) require a large number of e...

  15. Design optimization and experimental testing of the High-Flux Test Module of IFMIF

    Energy Technology Data Exchange (ETDEWEB)

    Leichtle, D. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany)], E-mail: leichtle@irs.fzk.de; Arbeiter, F.; Dolensky, B.; Fischer, U.; Gordeev, S.; Heinzel, V.; Ihli, T. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Moeslang, A. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Materialforschung, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Simakov, S.P.; Slobodchuk, V.; Stratmanns, E. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany)

    2009-04-30

    The design of the High-Flux Test Module of the International Fusion Material Irradiation Facility has been developed continuously in the past few years. The present paper highlights recent design achievements, including a thorough state-of-the-art validation assessment of CFD tools and models. Along with design related analyses exercises on manufacturing procedures have been performed. Recommendations for the use of container, rig, and capsule materials as well as recent progress in brazing of electrical heaters are discussed. A test matrix starting from High-Flux Test Module compartments, i.e. segments of the full module, with heated dummy rigs up to the full-scale module with instrumented irradiation rigs has been developed and the appropriate helium gas loop has been designed conceptually. A roadmap of the envisaged experimental activities is presented in accordance with the test loop facility construction and mock-up design and fabrication schedules.

  16. An analytical method to design the PID controller for the power control system of experimental nuclear reactor

    International Nuclear Information System (INIS)

    Chu Xinyuan; Li Fu; Huang Xiaojin; Zhang Liangju

    2004-01-01

    In order to make the design process for power control system of experimental nuclear reactor optimal, objective and analytical, an analytical design process which contains the model linearization, model reduction, theoretical design of PID controllers is discussed. This method is applied to the design of the power control system of an experimental nuclear reactor, the numerical simulation results prove that the design process is practical, and the control performance is satisfactory

  17. Optimization of Protease Production from Aspergillus Oryzae Sp. Using Box-Behnken Experimental Design

    Directory of Open Access Journals (Sweden)

    G. Srinu Babu

    2007-01-01

    Full Text Available Protease production by Aspergillus oryzae was optimized in shake-flask cultures using Box-Behnken experimental design. An empirical model was developed through response surface methodology to describe the relationship between tested variable (peptone, glucose, soyabeanmeal and pH. Maximum enzyme activity was attained with Peptone at 4 g∕L; temperature at 30 °C glucose at 6 g∕L; 30 °C and pH at 10. Experimental verification of the model showed a validation of 95%, which is more than 3-fold increase compare to the basal medium.

  18. Single-Case Experimental Designs: A Systematic Review of Published Research and Current Standards

    Science.gov (United States)

    Smith, Justin D.

    2013-01-01

    This article systematically reviews the research design and methodological characteristics of single-case experimental design (SCED) research published in peer-reviewed journals between 2000 and 2010. SCEDs provide researchers with a flexible and viable alternative to group designs with large sample sizes. However, methodological challenges have precluded widespread implementation and acceptance of the SCED as a viable complementary methodology to the predominant group design. This article includes a description of the research design, measurement, and analysis domains distinctive to the SCED; a discussion of the results within the framework of contemporary standards and guidelines in the field; and a presentation of updated benchmarks for key characteristics (e.g., baseline sampling, method of analysis), and overall, it provides researchers and reviewers with a resource for conducting and evaluating SCED research. The results of the systematic review of 409 studies suggest that recently published SCED research is largely in accordance with contemporary criteria for experimental quality. Analytic method emerged as an area of discord. Comparison of the findings of this review with historical estimates of the use of statistical analysis indicates an upward trend, but visual analysis remains the most common analytic method and also garners the most support amongst those entities providing SCED standards. Although consensus exists along key dimensions of single-case research design and researchers appear to be practicing within these parameters, there remains a need for further evaluation of assessment and sampling techniques and data analytic methods. PMID:22845874

  19. Optimal experimental designs for estimating Henry's law constants via the method of phase ratio variation.

    Science.gov (United States)

    Kapelner, Adam; Krieger, Abba; Blanford, William J

    2016-10-14

    When measuring Henry's law constants (k H ) using the phase ratio variation (PRV) method via headspace gas chromatography (G C ), the value of k H of the compound under investigation is calculated from the ratio of the slope to the intercept of a linear regression of the inverse G C response versus the ratio of gas to liquid volumes of a series of vials drawn from the same parent solution. Thus, an experimenter collects measurements consisting of the independent variable (the gas/liquid volume ratio) and dependent variable (the G C -1 peak area). A review of the literature found that the common design is a simple uniform spacing of liquid volumes. We present an optimal experimental design which estimates k H with minimum error and provides multiple means for building confidence intervals for such estimates. We illustrate performance improvements of our design with an example measuring the k H for Naphthalene in aqueous solution as well as simulations on previous studies. Our designs are most applicable after a trial run defines the linear G C response and the linear phase ratio to the G C -1 region (where the PRV method is suitable) after which a practitioner can collect measurements in bulk. The designs can be easily computed using our open source software optDesignSlopeInt, an R package on CRAN. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Overview of the TIBER II [Tokamak Ignition/Burn Experimental Reactor] design

    International Nuclear Information System (INIS)

    Henning, C.D.; Logan, B.G.

    1987-01-01

    The TIBER II Tokamak Ignition/Burn Experimental Reactor design is the result of efforts by numerous people and institutions, including many fusion laboratories, universities, and industries. While subsystems will be covered extensively in other reports, this overview will attempt to place the work in perspective. Major features of the design are compact size, low cost, and steady-state operation. These are achieved through plasma shaping and innovative features such as radiation tolerant magnets and optimized shielding. While TIBER II can operate in a pulsed mode, steady-state is preferred for nuclear testing. Current drive is achieved by a combination of lower hybrid and neutral beams. In addition, 10 MW of ECR is added for disruption control and current drive profiling. The TIBER II design has been the US option in preparation for the International Thermonuclear Experimental Reactor (ITER). Other equivalent national designs are the NET in Europe, the FER in Japan and the OTR in the USSR. These designs will help set the basis for the new international design effort. 9 refs

  1. Experimental study of liquid-metal target designs of accelerating-controlled systems

    International Nuclear Information System (INIS)

    Iarmonov, Mikhail; Makhov, Kirill; Novozhilova, Olga; Meluzov, A.G.; Beznosov, A.V.

    2011-01-01

    Models of a liquid-metal target of an accelerator-controlled system have been experimentally studied at the Nizhny Novgorod State Technical University to develop an optimal design of the flow part of the target. The main explored variants of liquid-metal targets are: Design with a diaphragm (firm-and-impervious plug) mounted on the pipe tap of particle transport from the accelerator cavity to the working cavity of the liquid-metal target. Design without a diaphragm on the pipe tab of particle transport from the accelerator. The study was carried out in a high-temperature liquid-metal test bench under the conditions close to full-scale ones: the temperature of the eutectic lead-bismuth alloy was 260degC - 400degC, the coolant mass flow was 5-80 t/h, and the rarefaction in the gas cavity was 10 5 Pa, the coefficient of geometric similarity equal to 1. The experimental studies of hydrodynamic characteristics of flow parts in the designs of targets under full-scale conditions indicated high efficiency of a target in triggering, operating, and deactivating modes. Research and technology instructions for designs of the flow part of the liquid-metal target, the target design as a whole, and the target circuit of accelerator-controlled systems were formulated as a result of the studies. (author)

  2. Experimental and numerical analysis of a new windowless target design of ADS

    International Nuclear Information System (INIS)

    Gu, Hanyang; Zhang, Xingliang; Gong, Shenjie; Lu, Donghua; Cheng, Xu

    2015-01-01

    Highlights: • A new windowless target design based on swirling flow is proposed. • VOF model with BSL RSM turbulent model can predict the free surface flow. • Experiment and CFD study preliminarily validate the feasibility of the target design. - Abstract: The formation and control method of the coolant free surface is one of the key technologies for the design of windowless targets in the Accelerator Driven Systems (ADSs). In this work, a new design of windowless target for ADS based on upward swirling flow is proposed to form a stable free surface without recirculation zones. Experimental and numerical investigations on the free surface flow have been performed in a prototypical windowless target using water as working fluid. The experimental results show that a stable free surface is achieved when the mass flow rate is higher than 4.0 m 3 /h and the shape of free surface profile greatly depends on the inlet flow rate. CFD simulations have been carried out using VOF method with different turbulent models. The numerical results show that the prediction of BSL Reynolds stress model agrees qualitatively well with the experimental results. The free surface profile of Lead–Bismuth-Eutectic (LBE) in the windowless target is very similar to that of water according to the simulation results. The feasibility of the new windowless target for ADS based on upward swirling flow is preliminary validated

  3. Optimal experimental designs for the estimation of thermal properties of composite materials

    Science.gov (United States)

    Scott, Elaine P.; Moncman, Deborah A.

    1994-01-01

    Reliable estimation of thermal properties is extremely important in the utilization of new advanced materials, such as composite materials. The accuracy of these estimates can be increased if the experiments are designed carefully. The objectives of this study are to design optimal experiments to be used in the prediction of these thermal properties and to then utilize these designs in the development of an estimation procedure to determine the effective thermal properties (thermal conductivity and volumetric heat capacity). The experiments were optimized by choosing experimental parameters that maximize the temperature derivatives with respect to all of the unknown thermal properties. This procedure has the effect of minimizing the confidence intervals of the resulting thermal property estimates. Both one-dimensional and two-dimensional experimental designs were optimized. A heat flux boundary condition is required in both analyses for the simultaneous estimation of the thermal properties. For the one-dimensional experiment, the parameters optimized were the heating time of the applied heat flux, the temperature sensor location, and the experimental time. In addition to these parameters, the optimal location of the heat flux was also determined for the two-dimensional experiments. Utilizing the optimal one-dimensional experiment, the effective thermal conductivity perpendicular to the fibers and the effective volumetric heat capacity were then estimated for an IM7-Bismaleimide composite material. The estimation procedure used is based on the minimization of a least squares function which incorporates both calculated and measured temperatures and allows for the parameters to be estimated simultaneously.

  4. Experimental Design of Electrocoagulation and Magnetic Technology for Enhancing Suspended Solids Removal from Synthetic Wastewater

    Directory of Open Access Journals (Sweden)

    Moh Faiqun Ni'am

    2014-10-01

    Full Text Available Design of experiments (DOE is one of the statistical method that is used as a tool to enhance and improve experimental quality. The changes to the variables of a process or system is supposed to give the optimal result (response and quite satisfactory. Experimental design can defined as a test or series of test series by varying the input variables (factors of a process that can known to cause changes in output (response. This paper presents the results of experimental design of wastewater treatment by electrocoagulation (EC technique. A combined magnet and electrocoagulation (EC technology were designed to increase settling velocity and to enhance suspended solid removal efficiencies from wastewater samples. In this experiment, a synthetic wastewater samples were prepared by mixing 700 mg of the milk powder in one litre of water and treated by using an acidic buffer solution. The monopolar iron (Fe plate anodes and cathodes were employed as electrodes. Direct current was varied in a range of between 0.5 and 1.1 A, and flowrate in a range of between 1.00 to 3.50 mL/s. One permanent magnets namely AlNiCo with a magnetic strength of 0.16T was used in this experiment. The results show that the magnetic field and the flowrate have major influences on suspended solids removal. The efficiency removals of suspended solids, turbidity and COD removal efficiencies at optimum conditions were found to be more than 85%, 95%, and 75%, respectively.

  5. Sliding spool design for reducing the actuation forces in direct operated proportional directional valves: Experimental validation

    International Nuclear Information System (INIS)

    Amirante, Riccardo; Distaso, Elia; Tamburrano, Paolo

    2016-01-01

    Highlights: • An innovative procedure to design a commercial proportional directional valve is shown. • Experimental tests are performed to demonstrate the flow force reduction. • The design is improved by means of a previously made optimization procedure. • Great reduction in the flow forces without reducing the flow rate is demonstrated. - Abstract: This paper presents the experimental validation of a new methodology for the design of the spool surfaces of four way three position direct operated proportional directional valves. The proposed methodology is based on the re-design of both the compensation profile (the central conical surface of the spool) and the lateral surfaces of the spool, in order to reduce the flow forces acting on the spool and hence the actuation forces. The aim of this work is to extend the application range of these valves to higher values of pressure and flow rate, thus avoiding the employment of more expensive two stage configurations in the case of high-pressure conditions and/or flow rate. The paper first presents a theoretical approach and a general strategy for the sliding spool design to be applied to any four way three position direct operated proportional directional valve. Then, the proposed approach is experimentally validated on a commercially available valve using a hydraulic circuit capable of measuring the flow rate as well as the actuation force over the entire spool stroke. The experimental results, performed using both the electronic driver provided by the manufacturer and a manual actuation system, show that the novel spool surface requires remarkably lower actuation forces compared to the commercial configuration, while maintaining the same flow rate trend as a function of the spool position.

  6. Statistical analysis of sonochemical synthesis of SAPO-34 nanocrystals using Taguchi experimental design

    International Nuclear Information System (INIS)

    Askari, Sima; Halladj, Rouein; Nazari, Mahdi

    2013-01-01

    Highlights: ► Sonochemical synthesis of SAPO-34 nanocrystals. ► Using Taguchi experimental design (L9) for optimizing the experimental procedure. ► The significant effects of all the ultrasonic parameters on the response. - Abstract: SAPO-34 nanocrystals with high crystallinity were synthesized by means of sonochemical method. An L9 orthogonal array of the Taguchi method was implemented to investigate the effects of sonication conditions on the preparation of SAPO-34 with respect to crystallinity of the final product phase. The experimental data establish the favorable phase crystallinity which is improved by increasing the ultrasonic power and the sonication temperature. In the case of ultrasonic irradiation time, however, an initial increases in crystallinity from 5 min to 15 min is followed by a decrease in crystallinity for longer sonication time

  7. Experimental analysis of stereotypy with applications of nonparametric statistical tests for alternating treatments designs.

    Science.gov (United States)

    Lloyd, Blair P; Finley, Crystal I; Weaver, Emily S

    2015-11-17

    Stereotypy is common in individuals with developmental disabilities and may become disruptive in the context of instruction. The purpose of this study was to embed brief experimental analyses in the context of reading instruction to evaluate effects of antecedent and consequent variables on latencies to and durations of stereotypy. We trained a reading instructor to implement a trial-based functional analysis and a subsequent antecedent analysis of stimulus features for an adolescent with autism in a reading clinic. We used alternating treatments designs with applications of nonparametric statistical analyses to control Type I error rates. Results of the experimental analyses suggested stereotypy was maintained by nonsocial reinforcement and informed the extent to which features of academic materials influenced levels of stereotypy. Results of nonparametric statistical analyses were consistent with conclusions based on visual analysis. Brief experimental analyses may be embedded in academic instruction to inform the stimulus conditions that influence stereotypy.

  8. Engineering at SLAC: Designing and constructing experimental devices for the Stanford Synchrotron Radiation Lightsource - Final Paper

    Energy Technology Data Exchange (ETDEWEB)

    Djang, Austin [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-08-22

    Thanks to the versatility of the beam lines at SSRL, research there is varied and benefits multiple fields. Each experiment requires a particular set of experiment equipment, which in turns requires its own particular assembly. As such, new engineering challenges arise from each new experiment. My role as an engineering intern has been to help solve these challenges, by designing and assembling experimental devices. My first project was to design a heated sample holder, which will be used to investigate the effect of temperature on a sample's x-ray diffraction pattern. My second project was to help set up an imaging test, which involved designing a cooled grating holder and assembling multiple positioning stages. My third project was designing a 3D-printed pencil holder for the SSRL workstations.

  9. An Efficient Experimental Design Strategy for Modelling and Characterization of Processes

    DEFF Research Database (Denmark)

    Tajsoleiman, Tannaz; Semenova, Daria; Oliveira Fernandes, Ana Carolina

    2017-01-01

    arises for parallel screening of multiple processes in reduced volumes within high throughput platforms. However, the level of accessible information from each set of experimental design remains to be one of the main issues particularly in the case of complex biosystems. This work introduces a novel......Designing robust, efficient and economic processes is a main challenge for the biotech industries. To achieve a well-designed bioprocess, understanding the ongoing phenomena and the involved reaction kinetics is crucial. By development of advanced miniaturized reactors, a promising opportunity...... generic Model-based Design of Experiments (M-DoE) routine with its main target being model development and system characterization. With the new M-DoE strategy, an improved set of informative experiments are suggested, which consequently reduces the demand for physical resources and analysis. The routine...

  10. Design of passive directional acoustic devices using Topology Optimization - from method to experimental validation

    DEFF Research Database (Denmark)

    Christiansen, Rasmus Ellebæk; Fernandez Grande, Efren

    2016-01-01

    The paper presents a topology optimization based method for designing acoustic focusing devices, capable of tailoring the sound emission pattern of one or several sources, across a chosen frequency band. The method is demonstrated numerically considering devices optimized for directional sound...... emission in two dimensions and is experimentally validated using three dimensional prints of the optimized designs. The emitted fields exhibit a level difference of at least 15 dB on axis relative to the off-axis directions, over frequency bands of approximately an octave. It is demonstrated to be possible...... to design focusing devices of dimensions comparable to the acoustic wavelength, a frequency range which is typically problematic, as well as devices operating at higher frequencies. The classical parabolic reflector is used as a benchmark. The devices designed using the proposed method are shown...

  11. Experimental investigation of undesired stable equilibria in pumpkin shape super-pressure balloon designs

    Science.gov (United States)

    Schur, W. W.

    2004-01-01

    Excess in skin material of a pneumatic envelope beyond what is required for minimum enclosure of a gas bubble is a necessary but by no means sufficient condition for the existence of multiple equilibrium configurations for that pneumatic envelope. The very design of structurally efficient super-pressure balloons of the pumpkin shape type requires such excess. Undesired stable equilibria in pumpkin shape balloons have been observed on experimental pumpkin shape balloons. These configurations contain regions with stress levels far higher than those predicted for the cyclically symmetric design configuration under maximum pressurization. Successful designs of pumpkin shape super-pressure balloons do not allow such undesired stable equilibria under full pressurization. This work documents efforts made so far and describes efforts still underway by the National Aeronautics and Space Administration's Balloon Program Office to arrive on guidance on the design of pumpkin shape super-pressure balloons that guarantee full and proper deployment.

  12. Experimental system design of liquid lithium-lead alloy bubbler for DFLL-TBM

    International Nuclear Information System (INIS)

    Xie Bo; Li Junge; Xu Shaomei; Weng Kuiping

    2011-01-01

    The liquid lithium-lead alloy bubbler is a very important composition in the tritium unit of Chinese Dual-Functional Lithium Lead Test Blanket Module (DFLL-TBM). In order to complete the construction and run of the bubbler experimental system,overall design of the system, main circuit design and auxiliary system design have been proposed on the basis of theoretical calculations for the interaction of hydrogen isotope with lithium-lead alloy and experiment for hydrogen extraction from liquid lithium-lead alloy by bubbling with rotational jet nozzle. The key of this design is gas-liquid exchange packed column, to achieve the measurement and extraction of hydrogen isotopes from liquid lithium-lead alloy. (authors)

  13. Design and R and D activities on ceramic breeder blanket for fusion experimental reactors in JAERI

    International Nuclear Information System (INIS)

    Kurasawa, T.; Takatsu, H.; Sato, S.; Nakahira, M.; Furuya, K.; Hashimoto, T.; Kawamura, H.; Kuroda, T.; Tsunematsu, T.; Seki, M.

    1995-01-01

    Design and R and D activities on ceramic breeder blanket of a fusion experimental reactor have been progressed in JAERI. A layered pebble bed type ceramic breeder blanket with water cooling is a prime candidate concept. Design activities have been concentrated on improvement of the design by conducting detailed analyses and also by fabrication procedure consideration based on the current technologies. A wide variety of R and Ds have also been conducted in accordance with the design activities. Development of fabrication technology of the blanket box structure and its mechanical testing, elementary testing on thermal performances of the pebble bed, and engineering-oriented material tests of breeder and beryllium pebbles are the main achievements during the last two years. (orig.)

  14. Experimental Investigations of Decentralised Control Design for The Stabilisation of Rotor-Gas Bearings

    DEFF Research Database (Denmark)

    Theisen, Lukas Roy Svane; Galeazzi, Roberto; Niemann, Hans Henrik

    2015-01-01

    -Box identification for the design of stabilising controllers, capable of enabling the active lubrication of the journal. The root locus analysis shows that two different control solutions are feasible for the dampening of the first two eigenfrequencies of the rotor-gas bearing in the horizontal and vertical...... frequencies. Active lubrication of the journal during operations could enhance the damping and stabilisation characteristics of the sytems, and this could be achieved by means of stabilising controllers. This paper investigates the feasibility of using reduced order models obtained through Grey...... directions. Hardening and softening P-lead controllers are designed based on the models experimentally identified, and salient features of both controllers are discussed. Both controllers are implemented and validated on the physical test rig. Experimental results confirm the validity of the proposed...

  15. Design and evaluation of experimental on line boron meter for Light Water Reactors

    International Nuclear Information System (INIS)

    Dighe, P.M.; Kamble, L.P.; Bhatnagar, P.V.; Das, D.; Swetha, M.; Patel, P.; Nathani, K.; Sen, S.K.

    2018-01-01

    Measurement of boron concentration in most PWR reactors is a critical activity, as dissolved boron is used to provide the required negative reactivity margins, whereas control rods provide control and safety actions. In nuclear plants, the usual and mandatory practice for boron concentration measurement is a manual, off line chemical titrimetry of boron. However, with current technological solutions such measurements can also be performed online to provide continuous signal to the operator. In the PWR reactors at Kudankulam present Online Boron meters (OLBM) installed are based on the imported design. Commercially OLBM are reported to be developed by Areva, Rolls-Royce etc. For indigenisation and to provide import substitute, efforts are underway to design and develop OLBMs. Towards this development an experimental set up was constructed taking inputs from Kudankulam OLBMs and by simulations using FLUKA Monte-Carlo software. The set up was experimentally evaluated for generation of calibration curves

  16. The Impact of Diagnostic Code Misclassification on Optimizing the Experimental Design of Genetic Association Studies

    Directory of Open Access Journals (Sweden)

    Steven J. Schrodi

    2017-01-01

    Full Text Available Diagnostic codes within electronic health record systems can vary widely in accuracy. It has been noted that the number of instances of a particular diagnostic code monotonically increases with the accuracy of disease phenotype classification. As a growing number of health system databases become linked with genomic data, it is critically important to understand the effect of this misclassification on the power of genetic association studies. Here, I investigate the impact of this diagnostic code misclassification on the power of genetic association studies with the aim to better inform experimental designs using health informatics data. The trade-off between (i reduced misclassification rates from utilizing additional instances of a diagnostic code per individual and (ii the resulting smaller sample size is explored, and general rules are presented to improve experimental designs.

  17. Pliocene Model Intercomparison (PlioMIP) Phase 2: Scientific Objectives and Experimental Design

    Science.gov (United States)

    Haywood, A. M.; Dowsett, H. J.; Dolan, A. M.; Rowley, D.; Abe-Ouchi, A.; Otto-Bliesner, B.; Chandler, M. A.; Hunter, S. J.; Lunt, D. J.; Pound, M.; hide

    2015-01-01

    The Pliocene Model Intercomparison Project (PlioMIP) is a co-ordinated international climate modelling initiative to study and understand climate and environments of the Late Pliocene, and their potential relevance in the context of future climate change. PlioMIP operates under the umbrella of the Palaeoclimate Modelling Intercomparison Project (PMIP), which examines multiple intervals in Earth history, the consistency of model predictions in simulating these intervals and their ability to reproduce climate signals preserved in geological climate archives. This paper provides a thorough model intercomparison project description, and documents the experimental design in a detailed way. Specifically, this paper describes the experimental design and boundary conditions that will be utilized for the experiments in Phase 2 of PlioMIP.

  18. Pliocene Model Intercomparison Project (PlioMIP): Experimental Design and Boundary Conditions (Experiment 2)

    Science.gov (United States)

    Haywood, A. M.; Dowsett, H. J.; Robinson, M. M.; Stoll, D. K.; Dolan, A. M.; Lunt, D. J.; Otto-Bliesner, B.; Chandler, M. A.

    2011-01-01

    The Palaeoclimate Modelling Intercomparison Project has expanded to include a model intercomparison for the mid-Pliocene warm period (3.29 to 2.97 million yr ago). This project is referred to as PlioMIP (the Pliocene Model Intercomparison Project). Two experiments have been agreed upon and together compose the initial phase of PlioMIP. The first (Experiment 1) is being performed with atmosphere only climate models. The second (Experiment 2) utilizes fully coupled ocean-atmosphere climate models. Following on from the publication of the experimental design and boundary conditions for Experiment 1 in Geoscientific Model Development, this paper provides the necessary description of differences and/or additions to the experimental design for Experiment 2.

  19. Experimental design: Case studies of diagnostics optimization for W7-X

    International Nuclear Information System (INIS)

    Dreier, H.; Dinklage, A.; Fischer, R.; Hartfuss, H.-J.; Hirsch, M.; Kornejew, P.; Pasch, E.; Turkin, Yu.

    2005-01-01

    The preparation of diagnostics for Wendelstein 7-X is accompanied by diagnostics simulations and optimization. Starting from the physical objectives, the design of diagnostics should incorporate predictive modelling (e.g. transport modelling) and simulations of respective measurements. Although technical constraints are governing design considerations, it appears that several design parameters of different diagnostics can be optimized. However, a general formulation for fusion diagnostics design in terms of optimization is lacking. In this paper, first case studies of Bayesian experimental design aiming at applications on W7-X diagnostics preparation are presented. The information gain of a measurement is formulated as a utility function which is expressed in terms of the Kullback-Leibler divergence. Then, the expected range of data is to be included and the resulting expected utility represents the objective for optimization. Bayesian probability theory gives a framework allowing us for an appropriate formulation of the design problem in terms of probability distribution functions. Results are obtained for the information gain from interferometry and for the design of polychromators for Thomson scattering. For interferometry, studies of the choice of line-of-sights for optimum signal and for the reproduction of gradient positions are presented for circular, elliptical and W7-X geometries. For Thomson scattering, the design of filter transmissions for density and temperature measurements are discussed. (author)

  20. Experimental design and analysis for accelerated degradation tests with Li-ion cells.

    Energy Technology Data Exchange (ETDEWEB)

    Doughty, Daniel Harvey; Thomas, Edward Victor; Jungst, Rudolph George; Roth, Emanuel Peter

    2003-08-01

    This document describes a general protocol (involving both experimental and data analytic aspects) that is designed to be a roadmap for rapidly obtaining a useful assessment of the average lifetime (at some specified use conditions) that might be expected from cells of a particular design. The proposed experimental protocol involves a series of accelerated degradation experiments. Through the acquisition of degradation data over time specified by the experimental protocol, an unambiguous assessment of the effects of accelerating factors (e.g., temperature and state of charge) on various measures of the health of a cell (e.g., power fade and capacity fade) will result. In order to assess cell lifetime, it is necessary to develop a model that accurately predicts degradation over a range of the experimental factors. In general, it is difficult to specify an appropriate model form without some preliminary analysis of the data. Nevertheless, assuming that the aging phenomenon relates to a chemical reaction with simple first-order rate kinetics, a data analysis protocol is also provided to construct a useful model that relates performance degradation to the levels of the accelerating factors. This model can then be used to make an accurate assessment of the average cell lifetime. The proposed experimental and data analysis protocols are illustrated with a case study involving the effects of accelerated aging on the power output from Gen-2 cells. For this case study, inadequacies of the simple first-order kinetics model were observed. However, a more complex model allowing for the effects of two concurrent mechanisms provided an accurate representation of the experimental data.

  1. Design of Passive Acoustic Wave Shaping Devices and Their Experimental Validation

    DEFF Research Database (Denmark)

    Christiansen, Rasmus Ellebæk; Sigmund, Ole; Fernandez Grande, Efren

    We discuss a topology optimization based approach for designing passive acoustic wave shaping devices and demonstrate its application to; directional sound emission [1], sound focusing and wave splitting. Optimized devices, numerical and experimental results are presented and benchmarked against...... in a target sub-domain. The objective is the integral of the deviation in pressure magnitude, between a pre-scribed sound field and the solution to the model problem for a given design realization over the target sub-domain. Filtering is used for regularization and to allow for meaningful optimization...

  2. Designation and Implementation of Microcomputer Principle and Interface Technology Virtual Experimental Platform Website

    Science.gov (United States)

    Gao, JinYue; Tang, Yin

    This paper explicitly discusses the designation and implementation thought and method of Microcomputer Principle and Interface Technology virtual experimental platform website construction. The instructional design of this platform mainly follows with the students-oriented constructivism learning theory, and the overall structure is subject to the features of teaching aims, teaching contents and interactive methods. Virtual experiment platform production and development should fully take the characteristics of network operation into consideration and adopt relevant technologies to improve the effect and speed of network software application in internet.

  3. Application of Plackett-Burman experimental design in the development of muffin using adlay flour

    Science.gov (United States)

    Valmorida, J. S.; Castillo-Israel, K. A. T.

    2018-01-01

    The application of Plackett-Burman experimental design was made to identify significant formulation and process variables in the development of muffin using adlay flour. Out of the seven screened variables, levels of sugar, levels of butter and baking temperature had the most significant influence on the product model in terms of physicochemical and sensory acceptability. Results of the experiment further demonstrate the effectiveness of Plackett-Burman design in choosing the best adlay variety for muffin production. Hence, the statistical method used in the study permits an efficient selection of important variables needed in the development of muffin from adlay which can be optimized using response surface methodology.

  4. An Effective Experimental Optimization Method for Wireless Power Transfer System Design Using Frequency Domain Measurement

    Directory of Open Access Journals (Sweden)

    Sangyeong Jeong

    2017-10-01

    Full Text Available This paper proposes an experimental optimization method for a wireless power transfer (WPT system. The power transfer characteristics of a WPT system with arbitrary loads and various types of coupling and compensation networks can be extracted by frequency domain measurements. The various performance parameters of the WPT system, such as input real/imaginary/apparent power, power factor, efficiency, output power and voltage gain, can be accurately extracted in a frequency domain by a single passive measurement. Subsequently, the design parameters can be efficiently tuned by separating the overall design steps into two parts. The extracted performance parameters of the WPT system were validated with time-domain experiments.

  5. Design, Analysis, Prototyping, and Experimental Evaluation of an Efficient Double Coil Magnetorheological Valve

    Directory of Open Access Journals (Sweden)

    Guoliang Hu

    2014-05-01

    Full Text Available A double coil magnetorheological (MR valve with an outer annular resistance gap was designed and prototyped. The finite element modeling and analysis of double coil MR valve were carried out using ANSYS/Emag software, and the optimal magnetic field distribution and magnetic flux density of the double coil MR valve were achieved. The mechanism of the pressure drop was studied by building a mathematical model of pressure drop in the double coil MR valve. The proposed double coil MR valve was prototyped and its performance was experimentally evaluated. The new MR valve design has improved the efficiency of double coil MR valve significantly.

  6. An experimental investigation of two 15 percent-scale wind tunnel fan-blade designs

    Science.gov (United States)

    Signor, David B.

    1988-01-01

    An experimental 3-D investigation of two fan-blade designs was conducted. The fan blades tested were 15 percent-scale models of blades to be used in the fan drive of the National Full-Scale Aerodynamic Complex at NASA Ames Research Center. NACA 65- and modified NACA 65-series sections incorporated increased thickness on the upper surface, between the leading edge and the one-half-chord position. Twist and taper were the same for both blade designs. The fan blades with modified 65-series sections were found to have an increased stall margin when they were compared with the unmodified blades.

  7. Design optimization and experimental testing of the High-Flux Test Module of IFMIF

    Energy Technology Data Exchange (ETDEWEB)

    Leichtle, D.; Arbeiter, F.; Dolensky, B.; Gordeev, S.; Ihli, T.; Moslang, A.; Slobodchuk, V.; Stratmanns, E. [Forschungszentrum Karlsruhe GmbH, FZK, Karlsruhe (Germany); Fischer, U.; Heinzel, V.; Simakov, S.P. [Forschungszentrum Karlsruhe, Zimer 203, Gebaeude 451, Abteilung HVT-TL, Karlsruhe (Germany)

    2007-07-01

    Full text of publication follows: The design of the International Fusion Material Irradiation Facility (IFMIF) has been advanced continuously. Within the Engineering Validation and Engineering Design Activities (EVEDA) phase as part of the Broader Approach agreement one task is devoted to the engineering design and experimental testing of a full-scale High-Flux Test Module (HFTM). A testing volume of 0.5 litres filled by qualified small scale specimens will be irradiated at displacement rates of 20-50 dpa/fpy in structural materials. The HFTM will also provide helium and hydrogen production to dpa ratios that reflect within the uncertainties the values expected in a DEMO fusion reactor The Forschungszentrum Karlsruhe has developed a HFTM design which closely follows the design premise of maximising the space available for irradiation specimens and in addition allows keeping the temperature nearly constant in the rigs containing the specimens. The present paper will highlight recent HFTM design achievements, including a thorough state-of-the-art validation assessment of CFD tools and models. Performance analyses as concurrent iterations of thermohydraulic, stress-strain and neutronics calculations will be summarized. Along with design related activities exercises on manufacturing procedures have been performed. Recommendations for the use of container, rig, and capsule materials as well as recent progress in brazing of electrical heaters and liquid metal filling of the specimen volume will be discussed. As testing of the HFTM up to a full-size mock-up has been defined as a major task within the EVEDA framework, a test matrix starting from HFTM compartments, i.e. segments of the full HFTM, with heated dummy rigs up to the full-scale HFTM with instrumented irradiation rigs has been developed and the appropriate helium gas loop has been devised conceptually. A road-map of the envisaged experimental activities will be presented in accordance with the test loop facility

  8. Experimental designs for detecting synergy and antagonism between two drugs in a pre-clinical study.

    Science.gov (United States)

    Sperrin, Matthew; Thygesen, Helene; Su, Ting-Li; Harbron, Chris; Whitehead, Anne

    2015-01-01

    The identification of synergistic interactions between combinations of drugs is an important area within drug discovery and development. Pre-clinically, large numbers of screening studies to identify synergistic pairs of compounds can often be ran, necessitating efficient and robust experimental designs. We consider experimental designs for detecting interaction between two drugs in a pre-clinical in vitro assay in the presence of uncertainty of the monotherapy response. The monotherapies are assumed to follow the Hill equation with common lower and upper asymptotes, and a common variance. The optimality criterion used is the variance of the interaction parameter. We focus on ray designs and investigate two algorithms for selecting the optimum set of dose combinations. The first is a forward algorithm in which design points are added sequentially. This is found to give useful solutions in simple cases but can lack robustness when knowledge about the monotherapy parameters is insufficient. The second algorithm is a more pragmatic approach where the design points are constrained to be distributed log-normally along the rays and monotherapy doses. We find that the pragmatic algorithm is more stable than the forward algorithm, and even when the forward algorithm has converged, the pragmatic algorithm can still out-perform it. Practically, we find that good designs for detecting an interaction have equal numbers of points on monotherapies and combination therapies, with those points typically placed in positions where a 50% response is expected. More uncertainty in monotherapy parameters leads to an optimal design with design points that are more spread out. Copyright © 2015 John Wiley & Sons, Ltd.

  9. Life on rock. Scaling down biological weathering in a new experimental design at Biosphere-2

    Science.gov (United States)

    Zaharescu, D. G.; Dontsova, K.; Burghelea, C. I.; Chorover, J.; Maier, R.; Perdrial, J. N.

    2012-12-01

    Biological colonization and weathering of bedrock on Earth is a major driver of landscape and ecosystem development, its effects reaching out into other major systems such climate and geochemical cycles of elements. In order to understand how microbe-plant-mycorrhizae communities interact with bedrock in the first phases of mineral weathering we developed a novel experimental design in the Desert Biome at Biosphere-2, University of Arizona (U.S.A). This presentation will focus on the development of the experimental setup. Briefly, six enclosed modules were designed to hold 288 experimental columns that will accommodate 4 rock types and 6 biological treatments. Each module is developed on 3 levels. A lower volume, able to withstand the weight of both, rock material and the rest of the structure, accommodates the sampling elements. A middle volume, houses the experimental columns in a dark chamber. A clear, upper section forms the habitat exposed to sunlight. This volume is completely sealed form exterior and it allows a complete control of its air and water parameters. All modules are connected in parallel with a double air purification system that delivers a permanent air flow. This setup is expected to provide a model experiment, able to test important processes in the interaction rock-life at grain-to- molecular scale.

  10. Design and experimental investigation of a Multi-segment plate concentrated photovoltaic solar energy system

    International Nuclear Information System (INIS)

    Wang, Gang; Chen, Zeshao; Hu, Peng

    2017-01-01

    Highlights: • A multi-segment plate concentrated photovoltaic solar energy system was proposed. • A prototype of this new concentrator was developed for experimental investigation. • Experimental investigation results showed a good concentrating uniformity. - Abstract: Solar energy is one of the most promising renewable energies and meaningful for the sustainable development of energy source. A multi-segment plate concentrated photovoltaic (CPV) solar power system was proposed in this paper, the design principle of the multi-segment plate concentrator of this solar power system was given, which could provide uniform solar radiation flux density distribution on solar cells. A prototype of this multi-segment plate CPV solar power system was developed for the experimental study, aiming at the investigations of solar radiation flux density distribution and PV performances under this concentrator design. The experimental results showed that the solar radiation flux density distribution provided by the multi-segment plate concentrator had a good uniformity, and the number and temperature of solar cells both influence the photoelectric transformation efficiency of the CPV solar power system.

  11. Peripheral myopization and visual performance with experimental rigid gas permeable and soft contact lens design.

    Science.gov (United States)

    Pauné, J; Queiros, A; Quevedo, L; Neves, H; Lopes-Ferreira, D; González-Méijome, J M

    2014-12-01

    To evaluate the performance of two experimental contact lenses (CL) designed to induce relative peripheral myopic defocus in myopic eyes. Ten right eyes of 10 subjects were fitted with three different CL: a soft experimental lens (ExpSCL), a rigid gas permeable experimental lens (ExpRGP) and a standard RGP lens made of the same material (StdRGP). Central and peripheral refraction was measured using a Grand Seiko open-field autorefractometer across the central 60° of the horizontal visual field. Ocular aberrations were measured with a Hartman-Shack aberrometer, and monocular contrast sensitivity function (CSF) was measured with a VCTS6500 without and with the three contact lenses. Both experimental lenses were able to increase significantly the relative peripheral myopic defocus up to -0.50 D in the nasal field and -1.00 D in the temporal field (p0.05). RGP lens design seems to be more effective to induce a significant myopic change in the relative peripheral refractive error. Both lenses preserve a good visual performance. The worsened optical quality observed in ExpRGP was due to an increased coma-like and spherical-like HOA. However, no impact on the visual quality as measured by CSF was observed. Copyright © 2014 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

  12. Quasi-experimental study designs series-paper 8: identifying quasi-experimental studies to inform systematic reviews.

    Science.gov (United States)

    Glanville, Julie; Eyers, John; Jones, Andrew M; Shemilt, Ian; Wang, Grace; Johansen, Marit; Fiander, Michelle; Rothstein, Hannah

    2017-09-01

    This article reviews the available evidence and guidance on methods to identify reports of quasi-experimental (QE) studies to inform systematic reviews of health care, public health, international development, education, crime and justice, and social welfare. Research, guidance, and examples of search strategies were identified by searching a range of databases, key guidance documents, selected reviews, conference proceedings, and personal communication. Current practice and research evidence were summarized. Four thousand nine hundred twenty-four records were retrieved by database searches, and additional documents were obtained by other searches. QE studies are challenging to identify efficiently because they have no standardized nomenclature and may be indexed in various ways. Reliable search filters are not available. There is a lack of specific resources devoted to collecting QE studies and little evidence on where best to search. Searches to identify QE studies should search a range of resources and, until indexing improves, use strategies that focus on the topic rather than the study design. Better definitions, better indexing in databases, prospective registers, and reporting guidance are required to improve the retrieval of QE studies and promote systematic reviews of what works based on the evidence from such studies. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

    Science.gov (United States)

    Kilkenny, Carol; Parsons, Nick; Kadyszewski, Ed; Festing, Michael F. W.; Cuthill, Innes C.; Fry, Derek; Hutton, Jane; Altman, Douglas G.

    2009-01-01

    For scientific, ethical and economic reasons, experiments involving animals should be appropriately designed, correctly analysed and transparently reported. This increases the scientific validity of the results, and maximises the knowledge gained from each experiment. A minimum amount of relevant information must be included in scientific publications to ensure that the methods and results of a study can be reviewed, analysed and repeated. Omitting essential information can raise scientific and ethical concerns. We report the findings of a systematic survey of reporting, experimental design and statistical analysis in published biomedical research using laboratory animals. Medline and EMBASE were searched for studies reporting research on live rats, mice and non-human primates carried out in UK and US publicly funded research establishments. Detailed information was collected from 271 publications, about the objective or hypothesis of the study, the number, sex, age and/or weight of animals used, and experimental and statistical methods. Only 59% of the studies stated the hypothesis or objective of the study and the number and characteristics of the animals used. Appropriate and efficient experimental design is a critical component of high-quality science. Most of the papers surveyed did not use randomisation (87%) or blinding (86%), to reduce bias in animal selection and outcome assessment. Only 70% of the publications that used statistical methods described their methods and presented the results with a measure of error or variability. This survey has identified a number of issues that need to be addressed in order to improve experimental design and reporting in publications describing research using animals. Scientific publication is a powerful and important source of information; the authors of scientific publications therefore have a responsibility to describe their methods and results comprehensively, accurately and transparently, and peer reviewers and

  14. Conceptual Design and Experimental Plans for the In-situ Test of Engineered Barrier System

    International Nuclear Information System (INIS)

    Lee, Jae Owan; Cho, Won Jin; Kwon, Sang Gi

    2009-12-01

    The overseas state-of-the-art of the in-situ test for the engineered barrier system was analyzed and the preliminary characterization of the fracture distribution in the test area of the KURT was carried out. Based upon these, the conceptual design of experimental apparatus for the in-situ test was completed and the detailed action plan was also established for its implementation

  15. Understanding Complexity and Self-Organization in a Defense Program Management Organization (Experimental Design)

    Science.gov (United States)

    2016-03-18

    and the interrelationship with the social bureaucratic influences . Experimental Research Design The Joint Tactical Radio System (JTRS) is a family...initiatives such as the Packard Commission study, Goldwater-Nichols Legislation, and more recently, the Better Buying Power initiative. While the DoD...potential communications pathways in an organizational structure) Self-Organizing Network Behavior The nodes in the network are specific individuals

  16. In silico design and screening of hypothetical MOF-74 analogs and their experimental synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Witman, Matthew [Department of Chemical and Biomolecular Engineering; University of California; Berkeley 94720; USA; Ling, Sanliang [Department of Chemistry; University College London; London WC1H 0AJ; UK; Anderson, Samantha [Laboratory of Molecular Simulation; Institut des Sciences et Ingénierie Chimiques; Ecole Polytechnique Fédérale de Lausanne (EPFL); CH-1951 Sion; Switzerland; Tong, Lianheng [Department of Physics; King' s College London; London; UK; Stylianou, Kyriakos C. [Laboratory of Molecular Simulation; Institut des Sciences et Ingénierie Chimiques; Ecole Polytechnique Fédérale de Lausanne (EPFL); CH-1951 Sion; Switzerland; Slater, Ben [Department of Chemistry; University College London; London WC1H 0AJ; UK; Smit, Berend [Department of Chemical and Biomolecular Engineering; University of California; Berkeley 94720; USA; Laboratory of Molecular Simulation; Haranczyk, Maciej [Computational Research Division; Lawrence Berkeley National Laboratory; Berkeley; USA; IMDEA Materials Institute

    2016-01-01

    We present thein silico designof MOFs exhibiting 1-dimensional rod topologies by enumerating MOF-74-type analogs based on the PubChem Compounds database. We simulate the adsorption behavior of CO2in the generated analogs and experimentally validate a novel MOF-74 analog, Mg2(olsalazine).

  17. Chemometrics in analytical chemistry-part I: history, experimental design and data analysis tools.

    Science.gov (United States)

    Brereton, Richard G; Jansen, Jeroen; Lopes, João; Marini, Federico; Pomerantsev, Alexey; Rodionova, Oxana; Roger, Jean Michel; Walczak, Beata; Tauler, Romà

    2017-10-01

    Chemometrics has achieved major recognition and progress in the analytical chemistry field. In the first part of this tutorial, major achievements and contributions of chemometrics to some of the more important stages of the analytical process, like experimental design, sampling, and data analysis (including data pretreatment and fusion), are summarised. The tutorial is intended to give a general updated overview of the chemometrics field to further contribute to its dissemination and promotion in analytical chemistry.

  18. Labeled experimental choice design for estimating attribute and availability cross effects with N attributes and specific brand attribute levels

    DEFF Research Database (Denmark)

    Nguyen, Thong Tien

    2011-01-01

    Experimental designs are required in widely used techniques in marketing research, especially for preference-based conjoint analysis and discrete-choice studies. Ideally, marketing researchers prefer orthogonal designs because this technique could give uncorrelated parameter estimates. However...

  19. Adaptive Designs for Non-inferiority Trials with Multiple Experimental Treatments.

    Science.gov (United States)

    Xu, Wenfu; Hu, Feifang; Cheung, Siu Hung

    2017-01-01

    The increase in the popularity of non-inferiority clinical trials represents the increasing need to search for substitutes for some reference (standard) treatments. A new treatment would be preferred to the standard treatment if the benefits of adopting it outweigh a possible clinically insignificant reduction in treatment efficacy (non-inferiority margin). Statistical procedures have recently been developed for treatment comparisons in non-inferiority clinical trials that have multiple experimental (new) treatments. An ethical concern for non-inferiority trials is that some patients undergo the less effective treatments; this problem is more serious when multiple experimental treatments are included in a balanced trial in which the sample sizes are the same for all experimental treatments. With the aim of giving fewer patients the inferior treatments, we propose a response-adaptive treatment allocation scheme that is based on the doubly adaptive biased coin design. The proposed adaptive design is also shown to be superior to the balanced design in terms of testing power.

  20. JEAB Research Over Time: Species Used, Experimental Designs, Statistical Analyses, and Sex of Subjects.

    Science.gov (United States)

    Zimmermann, Zachary J; Watkins, Erin E; Poling, Alan

    2015-10-01

    We examined the species used as subjects in every article published in the Journal of the Experimental Analysis of Behavior (JEAB) from 1958 through 2013. We also determined the sex of subjects in every article with human subjects (N = 524) and in an equal number of randomly selected articles with nonhuman subjects, as well as the general type of experimental designs used. Finally, the percentage of articles reporting an inferential statistic was determined at 5-year intervals. In all, 35,317 subjects were studied in 3,084 articles; pigeons ranked first and humans second in number used. Within-subject experimental designs were more popular than between-subjects designs regardless of whether human or nonhuman subjects were studied but were used in a higher percentage of articles with nonhumans (75.4 %) than in articles with humans (68.2 %). The percentage of articles reporting an inferential statistic has increased over time, and more than half of the articles published in 2005 and 2010 reported one. Researchers who publish in JEAB frequently depart from Skinner's preferred research strategy, but it is not clear whether such departures are harmful. Finally, the sex of subjects was not reported in a sizable percentage of articles with both human and nonhuman subjects. This is an unfortunate oversight.

  1. The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems.

    Directory of Open Access Journals (Sweden)

    Andrew White

    2016-12-01

    Full Text Available We explore the relationship among experimental design, parameter estimation, and systematic error in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many models of complex biological processes it is unknown what are the relevant physical mechanisms that must be included to explain system behaviors. As a consequence, models are often overly complex, with many practically unidentifiable parameters. Furthermore, which mechanisms are relevant/irrelevant vary among experiments. By selecting complementary experiments, experimental design may inadvertently make details that were ommitted from the model become relevant. When this occurs, the model will have a large systematic error and fail to give a good fit to the data. We use a simple hyper-model of model error to quantify a model's discrepancy and apply it to two models of complex biological processes (EGFR signaling and DNA repair with optimally selected experiments. We find that although parameters may be accurately estimated, the discrepancy in the model renders it less predictive than it was in the sloppy regime where systematic error is small. We introduce the concept of a sloppy system-a sequence of models of increasing complexity that become sloppy in the limit of microscopic accuracy. We explore the limits of accurate parameter estimation in sloppy systems and argue that identifying underlying mechanisms controlling system behavior is better approached by considering a hierarchy of models of varying detail rather than focusing on parameter estimation in a single model.

  2. Design of experimental system for supercritical CO2 fracturing under confining pressure conditions

    Science.gov (United States)

    Wang, H.; Lu, Q.; Li, X.; Yang, B.; Zheng, Y.; Shi, L.; Shi, X.

    2018-03-01

    Supercritical CO2 has the characteristics of low viscosity, high diffusion and zero surface tension, and it is considered as a new fluid for non-polluting and non-aqueous fracturing which can be used for shale gas development. Fracturing refers to a method of utilizing the high-pressure fluid to generate fractures in the rock formation so as to improve the oil and gas flow conditions and increase the oil and gas production. In this article, a new type of experimental system for supercritical CO2 fracturing under confining pressure conditions is designed, which is based on characteristics of supercritical CO2, shale reservoir and down-hole environment. The experimental system consists of three sub-systems, including supercritical CO2 generation system, supercritical CO2 fracturing system and data analysis system. It can be used to simulate supercritical CO2 fracturing under geo-stress conditions, thus to study the rock initiation pressure, the formation of the rock fractures, fractured surface morphology and so on. The experimental system has successfully carried out a series of supercritical CO2 fracturing experiments. The experimental results confirm the feasibility of the experimental system and the high efficiency of supercritical CO2 in fracturing tight rocks.

  3. Density functional theory and an experimentally-designed energy functional of electron density.

    Science.gov (United States)

    Miranda, David A; Bueno, Paulo R

    2016-09-21

    We herein demonstrate that capacitance spectroscopy (CS) experimentally allows access to the energy associated with the quantum mechanical ground state of many-electron systems. Priorly, electrochemical capacitance, C [small mu, Greek, macron] [ρ], was previously understood from conceptual and computational density functional theory (DFT) calculations. Thus, we herein propose a quantum mechanical experiment-based variational method for electron charging processes based on an experimentally-designed functional of the ground state electron density. In this methodology, the electron state density, ρ, and an energy functional of the electron density, E [small mu, Greek, macron] [ρ], can be obtained from CS data. CS allows the derivative of the electrochemical potential with respect to the electron density, (δ[small mu, Greek, macron][ρ]/δρ), to be obtained as a unique functional of the energetically minimised system, i.e., β/C [small mu, Greek, macron] [ρ], where β is a constant (associated with the size of the system) and C [small mu, Greek, macron] [ρ] is an experimentally observable quantity. Thus the ground state energy (at a given fixed external potential) can be obtained simply as E [small mu, Greek, macron] [ρ], from the experimental measurement of C [small mu, Greek, macron] [ρ]. An experimental data-set was interpreted to demonstrate the potential of this quantum mechanical experiment-based variational principle.

  4. Parametric modeling and optimal experimental designs for estimating isobolograms for drug interactions in toxicology.

    Science.gov (United States)

    Holland-Letz, Tim; Gunkel, Nikolas; Amtmann, Eberhard; Kopp-Schneider, Annette

    2017-11-27

    In toxicology and related areas, interaction effects between two substances are commonly expressed through a combination index [Formula: see text] evaluated separately at different effect levels and mixture ratios. Often, these indices are combined into a graphical representation, the isobologram. Instead of estimating the combination indices at the experimental mixture ratios only, we propose a simple parametric model for estimating the underlying interaction function. We integrate this approach into a joint model where both the parameters of the dose-response functions of the singular substances and the interaction parameters can be estimated simultaneously. As an additional benefit, this concept allows to determine optimal statistical designs for combination studies optimizing the estimation of the interaction function as a whole. From an optimal design perspective, finding the interaction parameters generally corresponds to a [Formula: see text]-optimality resp. [Formula: see text]-optimality design problem, while estimation of all underlying dose response parameters corresponds to a [Formula: see text]-optimality design problem. We show how optimal designs can be obtained in either case as well as how combination designs providing reasonable performance in regard to both criteria can be determined by putting a constraint on the efficiency in regard to one of the criteria and optimizing for the other. As all designs require prior information about model parameter values, which may be unreliable in practice, the effect of misspecifications is investigated as well.

  5. An overview of experimental designs in HPLC method development and validation.

    Science.gov (United States)

    Sahu, Prafulla Kumar; Ramisetti, Nageswara Rao; Cecchi, Teresa; Swain, Suryakanta; Patro, Chandra Sekhar; Panda, Jagadeesh

    2018-01-05

    Chemometric approaches have been increasingly viewed as precious complements to high performance liquid chromatographic practices, since a large number of variables can be simultaneously controlled to achieve the desired separations. Moreover, their applications may efficiently identify and optimize the significant factors to accomplish competent results through limited experimental trials. The present manuscript discusses usefulness of various chemometric approaches in high and ultra performance liquid chromatography for (i) methods development from dissolution studies and sample preparation to detection, considering the progressive substitution of traditional detectors with tandem mass spectrometry instruments and the importance of stability indicating assays (ii) method validation through screening and optimization designs. Choice of appropriate types of experimental designs so as to either screen the most influential factors or optimize the selected factors' combination and the mathematical models in chemometry have been briefly recalled and the advantages of chemometric approaches have been emphasized. The evolution of the design of experiments to the Quality by Design paradigm for method development has been reviewed and the Six Sigma practice as a quality indicator in chromatography has been explained. Chemometric applications and various strategies in chromatographic separations have been described. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Experimental design and Bayesian networks for enhancement of delta-endotoxin production by Bacillus thuringiensis.

    Science.gov (United States)

    Ennouri, Karim; Ayed, Rayda Ben; Hassen, Hanen Ben; Mazzarello, Maura; Ottaviani, Ennio

    2015-12-01

    Bacillus thuringiensis (Bt) is a Gram-positive bacterium. The entomopathogenic activity of Bt is related to the existence of the crystal consisting of protoxins, also called delta-endotoxins. In order to optimize and explain the production of delta-endotoxins of Bacillus thuringiensis kurstaki, we studied seven medium components: soybean meal, starch, KH₂PO₄, K₂HPO₄, FeSO₄, MnSO₄, and MgSO₄and their relationships with the concentration of delta-endotoxins using an experimental design (Plackett-Burman design) and Bayesian networks modelling. The effects of the ingredients of the culture medium on delta-endotoxins production were estimated. The developed model showed that different medium components are important for the Bacillus thuringiensis fermentation. The most important factors influenced the production of delta-endotoxins are FeSO₄, K2HPO₄, starch and soybean meal. Indeed, it was found that soybean meal, K₂HPO₄, KH₂PO₄and starch also showed positive effect on the delta-endotoxins production. However, FeSO4 and MnSO4 expressed opposite effect. The developed model, based on Bayesian techniques, can automatically learn emerging models in data to serve in the prediction of delta-endotoxins concentrations. The constructed model in the present study implies that experimental design (Plackett-Burman design) joined with Bayesian networks method could be used for identification of effect variables on delta-endotoxins variation.

  7. Managing Model Data Introduced Uncertainties in Simulator Predictions for Generation IV Systems via Optimum Experimental Design

    International Nuclear Information System (INIS)

    Turinsky, Paul J.; Abdel-Khalik, Hany S.; Stover, Tracy E.

    2011-01-01

    An optimization technique has been developed to select optimized experimental design specifications to produce data specifically designed to be assimilated to optimize a given reactor concept. Data from the optimized experiment is assimilated to generate posteriori uncertainties on the reactor concept's core attributes from which the design responses are computed. The reactor concept is then optimized with the new data to realize cost savings by reducing margin. The optimization problem iterates until an optimal experiment is found to maximize the savings. A new generation of innovative nuclear reactor designs, in particular fast neutron spectrum recycle reactors, are being considered for the application of closing the nuclear fuel cycle in the future. Safe and economical design of these reactors will require uncertainty reduction in basic nuclear data which are input to the reactor design. These data uncertainty propagate to design responses which in turn require the reactor designer to incorporate additional safety margin into the design, which often increases the cost of the reactor. Therefore basic nuclear data needs to be improved and this is accomplished through experimentation. Considering the high cost of nuclear experiments, it is desired to have an optimized experiment which will provide the data needed for uncertainty reduction such that a reactor design concept can meet its target accuracies or to allow savings to be realized by reducing the margin required due to uncertainty propagated from basic nuclear data. However, this optimization is coupled to the reactor design itself because with improved data the reactor concept can be re-optimized itself. It is thus desired to find the experiment that gives the best optimized reactor design. Methods are first established to model both the reactor concept and the experiment and to efficiently propagate the basic nuclear data uncertainty through these models to outputs. The representativity of the experiment

  8. Managing Model Data Introduced Uncertainties in Simulator Predictions for Generation IV Systems via Optimum Experimental Design

    Energy Technology Data Exchange (ETDEWEB)

    Turinsky, Paul J [North Carolina State Univ., Raleigh, NC (United States); Abdel-Khalik, Hany S [North Carolina State Univ., Raleigh, NC (United States); Stover, Tracy E [North Carolina State Univ., Raleigh, NC (United States)

    2011-03-01

    An optimization technique has been developed to select optimized experimental design specifications to produce data specifically designed to be assimilated to optimize a given reactor concept. Data from the optimized experiment is assimilated to generate posteriori uncertainties on the reactor concept’s core attributes from which the design responses are computed. The reactor concept is then optimized with the new data to realize cost savings by reducing margin. The optimization problem iterates until an optimal experiment is found to maximize the savings. A new generation of innovative nuclear reactor designs, in particular fast neutron spectrum recycle reactors, are being considered for the application of closing the nuclear fuel cycle in the future. Safe and economical design of these reactors will require uncertainty reduction in basic nuclear data which are input to the reactor design. These data uncertainty propagate to design responses which in turn require the reactor designer to incorporate additional safety margin into the design, which often increases the cost of the reactor. Therefore basic nuclear data needs to be improved and this is accomplished through experimentation. Considering the high cost of nuclear experiments, it is desired to have an optimized experiment which will provide the data needed for uncertainty reduction such that a reactor design concept can meet its target accuracies or to allow savings to be realized by reducing the margin required due to uncertainty propagated from basic nuclear data. However, this optimization is coupled to the reactor design itself because with improved data the reactor concept can be re-optimized itself. It is thus desired to find the experiment that gives the best optimized reactor design. Methods are first established to model both the reactor concept and the experiment and to efficiently propagate the basic nuclear data uncertainty through these models to outputs. The representativity of the experiment

  9. The influence of the design matrix on treatment effect estimates in the quantitative analyses of single-subject experimental design research.

    Science.gov (United States)

    Moeyaert, Mariola; Ugille, Maaike; Ferron, John M; Beretvas, S Natasha; Van den Noortgate, Wim

    2014-09-01

    The quantitative methods for analyzing single-subject experimental data have expanded during the last decade, including the use of regression models to statistically analyze the data, but still a lot of questions remain. One question is how to specify predictors in a regression model to account for the specifics of the design and estimate the effect size of interest. These quantitative effect sizes are used in retrospective analyses and allow synthesis of single-subject experimental study results which is informative for evidence-based decision making, research and theory building, and policy discussions. We discuss different design matrices that can be used for the most common single-subject experimental designs (SSEDs), namely, the multiple-baseline designs, reversal designs, and alternating treatment designs, and provide empirical illustrations. The purpose of this article is to guide single-subject experimental data analysts interested in analyzing and meta-analyzing SSED data. © The Author(s) 2014.

  10. Multi-objective experimental design for (13)C-based metabolic flux analysis.

    Science.gov (United States)

    Bouvin, Jeroen; Cajot, Simon; D'Huys, Pieter-Jan; Ampofo-Asiama, Jerry; Anné, Jozef; Van Impe, Jan; Geeraerd, Annemie; Bernaerts, Kristel

    2015-10-01

    (13)C-based metabolic flux analysis is an excellent technique to resolve fluxes in the central carbon metabolism but costs can be significant when using specialized tracers. This work presents a framework for cost-effective design of (13)C-tracer experiments, illustrated on two different networks. Linear and non-linear optimal input mixtures are computed for networks for Streptomyces lividans and a carcinoma cell line. If only glucose tracers are considered as labeled substrate for a carcinoma cell line or S. lividans, the best parameter estimation accuracy is obtained by mixtures containing high amounts of 1,2-(13)C2 glucose combined with uniformly labeled glucose. Experimental designs are evaluated based on a linear (D-criterion) and non-linear approach (S-criterion). Both approaches generate almost the same input mixture, however, the linear approach is favored due to its low computational effort. The high amount of 1,2-(13)C2 glucose in the optimal designs coincides with a high experimental cost, which is further enhanced when labeling is introduced in glutamine and aspartate tracers. Multi-objective optimization gives the possibility to assess experimental quality and cost at the same time and can reveal excellent compromise experiments. For example, the combination of 100% 1,2-(13)C2 glucose with 100% position one labeled glutamine and the combination of 100% 1,2-(13)C2 glucose with 100% uniformly labeled glutamine perform equally well for the carcinoma cell line, but the first mixture offers a decrease in cost of $ 120 per ml-scale cell culture experiment. We demonstrated the validity of a multi-objective linear approach to perform optimal experimental designs for the non-linear problem of (13)C-metabolic flux analysis. Tools and a workflow are provided to perform multi-objective design. The effortless calculation of the D-criterion can be exploited to perform high-throughput screening of possible (13)C-tracers, while the illustrated benefit of multi

  11. LOGICAL AND EXPERIMENTAL DESIGN FOR PHENOL DEGRADATION USING IMMOBILIZED ACINETOBACTER SP. CULTURE

    Directory of Open Access Journals (Sweden)

    Amro Abd Al Fattah Amara

    2010-05-01

    Full Text Available Phenol degradation processes were conducted through a series of enzymatic reactions effects and is affect by different components of the microbial metabolic flux. Using different optimization strategies like mutagenesis could lead to a successful optimization but also lead to lost of some important microbial features or to release a new virulence or unexpected characters. Plackett-Burman closes much gab between optimization, safety, time, cost, Man/hr, the complexity of the metabolic flux etc. Using Plackett-Burman experimental design lead to map the points affect in the optimization process by well understanding their request from nutrient and the best environmental condition required. In this study nine variables include pH (X1, oC (X2, glucose (X3, yeast extract (X4, meat extract (X5, NH4NO3 (X6, K-salt (X7, Mg-salt (X8 and trace element (X9 are optimized during phenol degradation by Acinetobacter sp., using Plackett-Burman design method. Plackett-Burman included 16 experiments, each was used in two levels, [-1] low and high [+1]. According to Blackett-Burman design experiments the maximum degradation rate was 31.25 mg/l/h. Logical and statistical analysis of the data lead to select pH, Temperature and Meat extract as three factors affecting on phenol degradation rate. These three variables have been used in Box-Behnken experimental design for further optimization. Meat extract, which is not statistically recommended for optimization has been used while it can substitute trace element, which is statistically significant. Glucose, which is statistically significant, did not included while it has a negative effect and gave the best result at 0 g/l amount. Glucose has been completely omitted from the media.  pH, temperature and meat extract were used in fifteen experiments each was used in three levels, –1, 0, and +1 according to Box-Behnken design. Microsoft Excel 2002 solver tool was used to optimize the model created from Box-Behnken. The

  12. Using an Animal Group Vigilance Practical Session to Give Learners a "Heads-Up" to Problems in Experimental Design

    Science.gov (United States)

    Rands, Sean A.

    2011-01-01

    The design of experimental ecological fieldwork is difficult to teach to classes, particularly when protocols for data collection are normally carefully controlled by the class organiser. Normally, reinforcement of the some problems of experimental design such as the avoidance of pseudoreplication and appropriate sampling techniques does not occur…

  13. Optimized polymer flooding projects via combination of experimental design and reservoir simulation

    Directory of Open Access Journals (Sweden)

    Ali Bengar

    2017-12-01

    Full Text Available The conventional approach for an EOR process is to compare the reservoir properties with those of successful worldwide projects. However, some proper cases may be neglected due to the lack of reliable data. A combination of experimental design and reservoir simulation is an alternative approach. In this work, the fractional factorial design suggests some numerical experiments which their results are analyzed by statistical inference. After determination of the main effects and interactions, the most important parameters of polymer flooding are studied by ANOVA method and Pareto and Tornado charts. Analysis of main effects shows that the oil viscosity, connate water saturation and the horizontal permeability are the 3 deciding factors in oil production. The proposed methodology can help to select the good candidate reservoirs for polymer flooding. Keywords: Polymer flooding, Fractional factorial design, Reservoir simulation, P-value, ANOVA

  14. The Best Location for Speed Bump Installation Using Experimental Design Methodology

    Directory of Open Access Journals (Sweden)

    Alireza Khademi

    2013-12-01

    Full Text Available Speed bumps, as traffic calming devices, have been extensively used to reduce traffic speed on local streets. This study represents a unique application of experimental design methodology where the effects of some controllable factors in determining the best location for installing speed bumps before stop points (e.g. entry gates, road junctions were investigated. Through Classical Design of Experiments (DOE, the optimum location of the speed bump was obtained based on the graphical plots of the significant effects. The speed at the stop point was treated as the response and minimum speed is desirable. Design-Expert® software was used to evaluate and analyze the results obtained. The suggested mathematical model effectively explains the performance indicators within the ranges of the factors. The car speed is the most significant factor that affects the distance-time in comparison with other factors, which provides secondary contributions.

  15. He-cooled divertor for DEMO: Experimental verification of the conceptual modular design

    International Nuclear Information System (INIS)

    Norajitra, P.; Gervash, A.; Giniyatulin, R.; Ihli, T.; Krauss, W.; Kruessmann, R.; Kuznetsov, V.; Makhankov, A.; Mazul, I.; Ovchinnikov, I.

    2006-01-01

    A modular He-cooled divertor concept is being developed at the Forschungszentrum Karlsruhe. The design goal is to withstand a high heat flux of 10 MW/m 2 at least. The work programme of 2004 focused on experiments to verify the design and thermohydraulics layout. In cooperation with the Efremov Institute, experimental investigations were performed for the joining of tungsten parts and/or tungsten parts with steel and the fabrication of divertor components from tungsten. Moreover, gas puffing experiments were carried out with a stationary approach to measuring pressure loss and heat transfer for the purpose of screening the design options and verifying the computational fluid dynamics (CFD) calculations. The status and results of the technological and helium experiments shall be outlined in this report

  16. A Simulation Study of Threats to Validity in Quasi-Experimental Designs: Interrelationship between Design, Measurement, and Analysis

    Science.gov (United States)

    Holgado-Tello, Fco. P.; Chacón-Moscoso, Salvador; Sanduvete-Chaves, Susana; Pérez-Gil, José A.

    2016-01-01

    The Campbellian tradition provides a conceptual framework to assess threats to validity. On the other hand, different models of causal analysis have been developed to control estimation biases in different research designs. However, the link between design features, measurement issues, and concrete impact estimation analyses is weak. In order to provide an empirical solution to this problem, we use Structural Equation Modeling (SEM) as a first approximation to operationalize the analytical implications of threats to validity in quasi-experimental designs. Based on the analogies established between the Classical Test Theory (CTT) and causal analysis, we describe an empirical study based on SEM in which range restriction and statistical power have been simulated in two different models: (1) A multistate model in the control condition (pre-test); and (2) A single-trait-multistate model in the control condition (post-test), adding a new mediator latent exogenous (independent) variable that represents a threat to validity. Results show, empirically, how the differences between both the models could be partially or totally attributed to these threats. Therefore, SEM provides a useful tool to analyze the influence of potential threats to validity. PMID:27378991

  17. A Simulation Study of Threats to Validity in Quasi-Experimental Designs: Interrelationship between Design, Measurement, and Analysis.

    Science.gov (United States)

    Holgado-Tello, Fco P; Chacón-Moscoso, Salvador; Sanduvete-Chaves, Susana; Pérez-Gil, José A

    2016-01-01

    The Campbellian tradition provides a conceptual framework to assess threats to validity. On the other hand, different models of causal analysis have been developed to control estimation biases in different research designs. However, the link between design features, measurement issues, and concrete impact estimation analyses is weak. In order to provide an empirical solution to this problem, we use Structural Equation Modeling (SEM) as a first approximation to operationalize the analytical implications of threats to validity in quasi-experimental designs. Based on the analogies established between the Classical Test Theory (CTT) and causal analysis, we describe an empirical study based on SEM in which range restriction and statistical power have been simulated in two different models: (1) A multistate model in the control condition (pre-test); and (2) A single-trait-multistate model in the control condition (post-test), adding a new mediator latent exogenous (independent) variable that represents a threat to validity. Results show, empirically, how the differences between both the models could be partially or totally attributed to these threats. Therefore, SEM provides a useful tool to analyze the influence of potential threats to validity.

  18. Development of a Model for Measuring Scientific Processing Skills Based on Brain-Imaging Technology: Focused on the Experimental Design Process

    Science.gov (United States)

    Lee, Il-Sun; Byeon, Jung-Ho; Kim, Young-shin; Kwon, Yong-Ju

    2014-01-01

    The purpose of this study was to develop a model for measuring experimental design ability based on functional magnetic resonance imaging (fMRI) during biological inquiry. More specifically, the researchers developed an experimental design task that measures experimental design ability. Using the developed experimental design task, they measured…

  19. Facility for Advanced Accelerator Experimental Tests at SLAC (FACET) Conceptual Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Amann, J.; Bane, K.; /SLAC

    2009-10-30

    This Conceptual Design Report (CDR) describes the design of FACET. It will be updated to stay current with the developing design of the facility. This CDR begins as the baseline conceptual design and will evolve into an 'as-built' manual for the completed facility. The Executive Summary, Chapter 1, gives an introduction to the FACET project and describes the salient features of its design. Chapter 2 gives an overview of FACET. It describes the general parameters of the machine and the basic approaches to implementation. The FACET project does not include the implementation of specific scientific experiments either for plasma wake-field acceleration for other applications. Nonetheless, enough work has been done to define potential experiments to assure that the facility can meet the requirements of the experimental community. Chapter 3, Scientific Case, describes the planned plasma wakefield and other experiments. Chapter 4, Technical Description of FACET, describes the parameters and design of all technical systems of FACET. FACET uses the first two thirds of the existing SLAC linac to accelerate the beam to about 20GeV, and compress it with the aid of two chicanes, located in Sector 10 and Sector 20. The Sector 20 area will include a focusing system, the generic experimental area and the beam dump. Chapter 5, Management of Scientific Program, describes the management of the scientific program at FACET. Chapter 6, Environment, Safety and Health and Quality Assurance, describes the existing programs at SLAC and their application to the FACET project. It includes a preliminary analysis of safety hazards and the planned mitigation. Chapter 7, Work Breakdown Structure, describes the structure used for developing the cost estimates, which will also be used to manage the project. The chapter defines the scope of work of each element down to level 3.

  20. Facility for Advanced Accelerator Experimental Tests at SLAC (FACET) Conceptual Design Report

    International Nuclear Information System (INIS)

    Amann, J.; Bane, K.

    2009-01-01

    This Conceptual Design Report (CDR) describes the design of FACET. It will be updated to stay current with the developing design of the facility. This CDR begins as the baseline conceptual design and will evolve into an 'as-built' manual for the completed facility. The Executive Summary, Chapter 1, gives an introduction to the FACET project and describes the salient features of its design. Chapter 2 gives an overview of FACET. It describes the general parameters of the machine and the basic approaches to implementation. The FACET project does not include the implementation of specific scientific experiments either for plasma wake-field acceleration for other applications. Nonetheless, enough work has been done to define potential experiments to assure that the facility can meet the requirements of the experimental community. Chapter 3, Scientific Case, describes the planned plasma wakefield and other experiments. Chapter 4, Technical Description of FACET, describes the parameters and design of all technical systems of FACET. FACET uses the first two thirds of the existing SLAC linac to accelerate the beam to about 20GeV, and compress it with the aid of two chicanes, located in Sector 10 and Sector 20. The Sector 20 area will include a focusing system, the generic experimental area and the beam dump. Chapter 5, Management of Scientific Program, describes the management of the scientific program at FACET. Chapter 6, Environment, Safety and Health and Quality Assurance, describes the existing programs at SLAC and their application to the FACET project. It includes a preliminary analysis of safety hazards and the planned mitigation. Chapter 7, Work Breakdown Structure, describes the structure used for developing the cost estimates, which will also be used to manage the project. The chapter defines the scope of work of each element down to level 3.

  1. Study Design Rigor in Animal-Experimental Research Published in Anesthesia Journals.

    Science.gov (United States)

    Hoerauf, Janine M; Moss, Angela F; Fernandez-Bustamante, Ana; Bartels, Karsten

    2018-01-01

    Lack of reproducibility of preclinical studies has been identified as an impediment for translation of basic mechanistic research into effective clinical therapies. Indeed, the National Institutes of Health has revised its grant application process to require more rigorous study design, including sample size calculations, blinding procedures, and randomization steps. We hypothesized that the reporting of such metrics of study design rigor has increased over time for animal-experimental research published in anesthesia journals. PubMed was searched for animal-experimental studies published in 2005, 2010, and 2015 in primarily English-language anesthesia journals. A total of 1466 publications were graded on the performance of sample size estimation, randomization, and blinding. Cochran-Armitage test was used to assess linear trends over time for the primary outcome of whether or not a metric was reported. Interrater agreement for each of the 3 metrics (power, randomization, and blinding) was assessed using the weighted κ coefficient in a 10% random sample of articles rerated by a second investigator blinded to the ratings of the first investigator. A total of 1466 manuscripts were analyzed. Reporting for all 3 metrics of experimental design rigor increased over time (2005 to 2010 to 2015): for power analysis, from 5% (27/516), to 12% (59/485), to 17% (77/465); for randomization, from 41% (213/516), to 50% (243/485), to 54% (253/465); and for blinding, from 26% (135/516), to 38% (186/485), to 47% (217/465). The weighted κ coefficients and 98.3% confidence interval indicate almost perfect agreement between the 2 raters beyond that which occurs by chance alone (power, 0.93 [0.85, 1.0], randomization, 0.91 [0.85, 0.98], and blinding, 0.90 [0.84, 0.96]). Our hypothesis that reported metrics of rigor in animal-experimental studies in anesthesia journals have increased during the past decade was confirmed. More consistent reporting, or explicit justification for absence

  2. A design and experimental verification methodology for an energy harvester skin structure

    Science.gov (United States)

    Lee, Soobum; Youn, Byeng D.

    2011-05-01

    This paper presents a design and experimental verification methodology for energy harvesting (EH) skin, which opens up a practical and compact piezoelectric energy harvesting concept. In the past, EH research has primarily focused on the design improvement of a cantilever-type EH device. However, such EH devices require additional space for proof mass and fixture and sometimes result in significant energy loss as the clamping condition becomes loose. Unlike the cantilever-type device, the proposed design is simply implemented by laminating a thin piezoelectric patch onto a vibrating structure. The design methodology proposed, which determines a highly efficient piezoelectric material distribution, is composed of two tasks: (i) topology optimization and (ii) shape optimization of the EH material. An outdoor condensing unit is chosen as a case study among many engineered systems with harmonic vibrating configuration. The proposed design methodology determined an optimal PZT material configuration on the outdoor unit skin structure. The designed EH skin was carefully prototyped to demonstrate that it can generate power up to 3.7 mW, which is sustainable for operating wireless sensor units for structural health monitoring and/or building automation.

  3. A design and experimental verification methodology for an energy harvester skin structure

    International Nuclear Information System (INIS)

    Lee, Soobum; Youn, Byeng D

    2011-01-01

    This paper presents a design and experimental verification methodology for energy harvesting (EH) skin, which opens up a practical and compact piezoelectric energy harvesting concept. In the past, EH research has primarily focused on the design improvement of a cantilever-type EH device. However, such EH devices require additional space for proof mass and fixture and sometimes result in significant energy loss as the clamping condition becomes loose. Unlike the cantilever-type device, the proposed design is simply implemented by laminating a thin piezoelectric patch onto a vibrating structure. The design methodology proposed, which determines a highly efficient piezoelectric material distribution, is composed of two tasks: (i) topology optimization and (ii) shape optimization of the EH material. An outdoor condensing unit is chosen as a case study among many engineered systems with harmonic vibrating configuration. The proposed design methodology determined an optimal PZT material configuration on the outdoor unit skin structure. The designed EH skin was carefully prototyped to demonstrate that it can generate power up to 3.7 mW, which is sustainable for operating wireless sensor units for structural health monitoring and/or building automation. (technical note)

  4. Experimental investigation of shaping disturbance observer design for motion control of precision mechatronic stages with resonances

    Science.gov (United States)

    Yang, Jin; Hu, Chuxiong; Zhu, Yu; Wang, Ze; Zhang, Ming

    2017-08-01

    In this paper, shaping disturbance observer (SDOB) is investigated for precision mechatronic stages with middle-frequency zero/pole type resonance to achieve good motion control performance in practical manufacturing situations. Compared with traditional standard disturbance observer (DOB), in SDOB a pole-zero cancellation based shaping filter is cascaded to the mechatronic stage plant to meet the challenge of motion control performance deterioration caused by actual resonance. Noting that pole-zero cancellation is inevitably imperfect and the controller may even consequently become unstable in practice, frequency domain stability analysis is conducted to find out how each parameter of the shaping filter affects the control stability. Moreover, the robust design criterion of the shaping filter, and the design procedure of SDOB, are both proposed to guide the actual design and facilitate practical implementation. The SDOB with the proposed design criterion is applied to a linear motor driven stage and a voice motor driven stage, respectively. Experimental results consistently validate the effectiveness nature of the proposed SDOB scheme in practical mechatronics motion applications. The proposed SDOB design actually could be an effective unit in the controller design for motion stages of mechanical manufacture equipments.

  5. Design study of superconducting magnets for tokamak experimental fusion reactor, (1)

    International Nuclear Information System (INIS)

    1980-03-01

    Design study has been made of superconducting magnets for a Tokamak experimental fusion reactor: toroidal field magnet design, poloidal field magnet design, refrigeration system design, magnet safety analysis, and magnet assembling and disassembling system design. A maximum toroidal field in the coil is 11.0 T, providing 5.5 T at plasma center. Nb 3 Sn superconducting cable is used to attain the toroidal field of 11 T. The coil bore is 7.3 x 11.2 m, and the coil shape is deformed constant-tension D-shape. The magnetomotive force is 185.6 MAT, and the operational current is 25.9 kA. In poloidal field magnet design, the coil is pancake-wound Nb 3 Sn conductor. The conductor is enclosed in Ti-alloy sheath, which serves also as helium containment vessel. The conductor is cooled by forced flow supercritical helium of 7 atm and 4.6 K, and the operational current is 25 -- 27 kA. (author)

  6. Back up core designs for the experimental multi-purpose VHTR

    International Nuclear Information System (INIS)

    Aochi, Tetsuo; Yasuno, Takehiko; Miyamoto, Yoshiaki; Shindo, Ryuichi; Ikushima, Takeshi

    1979-02-01

    For the Experimental Multi-Purpose Very High Temperature Reactor (thermal power 50 MW and reactor outlet helium temperature 1000 0 C), design studies have been made of two backup cores loaded with new-type fuel elements. The purpose is to improve core operational characteristics, especially in thermohydraulics, of the reference design core consisting of pin-in-block type fuel elements having externally cooled hollow fuel rods. In this report are described the design principles and the analyses made of nuclear, thermal and hydraulic, fuel, and safety performances to determine the backup fuel and core design parameters. The first backup core (SP fuel core) is composed of fuel elements with internally cooled fuel rods (semi-pin), 36 rods in each standard element and 18 rods in each control element. The second backup core (MH fuel core) is composed of multihole fuel elements. 102 fuel and 54 coolant holes in each standard element and 30 fuel and 18 coolant holes in each control element. Either of the cores has 73 fuel columns 4 m high; the arrangement of active core and reactor internal structures is the same as that in the reference design. The backup cores meet nearly all design requirements of the VHTR, permitting the rated power operation with coolant Reynolds number of over 10,000 in the SP core and over 6,000 in the MH core. (author)

  7. Experimental and Sampling Design for the INL-2 Sample Collection Operational Test

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F.; Amidan, Brett G.; Matzke, Brett D.

    2009-02-16

    This report describes the experimental and sampling design developed to assess sampling approaches and methods for detecting contamination in a building and clearing the building for use after decontamination. An Idaho National Laboratory (INL) building will be contaminated with BG (Bacillus globigii, renamed Bacillus atrophaeus), a simulant for Bacillus anthracis (BA). The contamination, sampling, decontamination, and re-sampling will occur per the experimental and sampling design. This INL-2 Sample Collection Operational Test is being planned by the Validated Sampling Plan Working Group (VSPWG). The primary objectives are: 1) Evaluate judgmental and probabilistic sampling for characterization as well as probabilistic and combined (judgment and probabilistic) sampling approaches for clearance, 2) Conduct these evaluations for gradient contamination (from low or moderate down to absent or undetectable) for different initial concentrations of the contaminant, 3) Explore judgment composite sampling approaches to reduce sample numbers, 4) Collect baseline data to serve as an indication of the actual levels of contamination in the tests. A combined judgmental and random (CJR) approach uses Bayesian methodology to combine judgmental and probabilistic samples to make clearance statements of the form "X% confidence that at least Y% of an area does not contain detectable contamination” (X%/Y% clearance statements). The INL-2 experimental design has five test events, which 1) vary the floor of the INL building on which the contaminant will be released, 2) provide for varying the amount of contaminant released to obtain desired concentration gradients, and 3) investigate overt as well as covert release of contaminants. Desirable contaminant gradients would have moderate to low concentrations of contaminant in rooms near the release point, with concentrations down to zero in other rooms. Such gradients would provide a range of contamination levels to challenge the sampling

  8. An innovative approach for planning and execution of pre-experimental runs for Design of Experiments

    Directory of Open Access Journals (Sweden)

    Muhammad Arsalan Farooq

    2016-09-01

    Full Text Available This paper addresses the study of the pre-experimental planning phase of the Design of Experiments (DoE in order to improve the final product quality. The pre-experimental planning phase includes a clear identification of the problem statement, selection of control factors and their respective levels and ranges. To improve production quality based on the DoE a new approach for the pre-experimental planning phase, called Non-Conformity Matrix (NCM, is presented. This article also addresses the key steps of the pre-experimental runs considering a consumer goods manufacturing process. Results of the application for an industrial case show that this methodology can support a clear definition of the problem and also a correct identification of the factor ranges in particular situations. The proposed new approach allows modeling the entire manufacturing system holistically and correctly defining the factor ranges and respective levels for a more effective application of DoE. This new approach can be a useful resource for both research and industrial practitioners who are dedicated to large DoE projects with unknown factor interactions, when the operational levels and ranges are not completely defined.

  9. Control System Design for Active Lubrication with Theoretical and Experimental Examples

    DEFF Research Database (Denmark)

    Santos, Ilmar; Scalabrin, A.

    2003-01-01

    This work focuses on the theoretical and experimental behavior of rigid rotors controlled by tilting-pad journal bearings with active oil injection. Initially the mathematical model of the active bearing is presented: The equations that describe the dynamics of hydraulic actuators are introduced...... into the equations of the lubricant, resulting in a new form of the Reynolds equation for active lubrication. The global model of the system is obtained by coupling the equation of motion of the rigid rotor with the stiffness and damping of the active oil film. This global model is then used to design the control...... system of the active bearing based on root locus curves. The active system stability is analyzed by calculating its eigenvalues and frequency response curves. The theoretical and experimental results show that this kind of bearing can significantly reduce the vibration level of rotating machinery....

  10. Control System Design for Active Lubrication with Theoretical and Experimental Examples

    DEFF Research Database (Denmark)

    Santos, Ilmar; Scalabrin, A.

    2003-01-01

    into the equations of the lubricant, resulting in a new form of the Reynolds equation for active lubrication. The global model of the system is obtained by coupling the equation of motion of the rigid rotor with the stiffness and damping of the active oil film. This global model is then used to design the control......This work focuses on the theoretical and experimental behavior of rigid rotors controlled by tilting-pad journal bearings with active oil injection. Initially the mathematical model of the active bearing is presented: The equations that describe the dynamics of hydraulic actuators are introduced...... system of the active bearing based on root locus curves. The active system stability is analyzed by calculating its eigenvalues and frequency response curves. The theoretical and experimental results show that this kind of bearing can significantly reduce the vibration level of rotating machinery....

  11. Increased performance in a bottom-up designed robot by experimentally guided redesign

    DEFF Research Database (Denmark)

    Larsen, Jørgen Christian

    2013-01-01

    Purpose – Using a bottom-up, model-free approach when building robots is often seen as a less scientific way, compared to a top-down model-based approach, because the results are not easily generalizable to other systems. The authors, however, hypothesize that this problem may be addressed by using...... the bottom-up, mode-free approach, the authors used the robotic construction kit, LocoKit. This construction kit allows researchers to construct legged robots, without having a mathematical model beforehand. The authors used no specific mathematical model to design the robot, but instead used intuition...... and took inspiration from biology. The results were afterwards compared with results gained from biology, to see if the robot has some of the key elements the authors were looking for. Findings – With the use of LocoKit as the experimental platform, combined with known experimental measurement methods from...

  12. Design and experimental study of a multi-modal piezoelectric energy harvester

    Energy Technology Data Exchange (ETDEWEB)

    Xiong, Xing Yu [School of Energy, Power and Mechanical Engineering, North China Electric Power University, Beijing (China); Oyadiji, S. Olutunde [School of Mechanical, Aerospace and Civil Engineering, The University of Manchester, Manchester (United States)

    2017-01-15

    A multi-modal piezoelectric vibration energy harvester is designed in this article. It consists of a cantilevered base beam and some upper and lower layer beams with rigid masses bonded between the beams as spacers. For a four-layer harvester subjected to random base excitations, relocating the mass positions leads to the generation of up to four close resonance frequencies over the frequency range from 10 Hz to 100 Hz with relative large power output. The harvesters are connected with a resistance decade box and the frequency response functions of the voltage and power on resistive loads are determined. The experimental results are validated with the simulation results using the finite element method. On a certain level of power output, the experimental results show that the multi-modal harvesters can generate a frequency band that is more than two times greater than the frequency band produced by a cantilevered beam harvester.

  13. Optimization Method of a Low Cost, High Performance Ceramic Proppant by Orthogonal Experimental Design

    Science.gov (United States)

    Zhou, Y.; Tian, Y. M.; Wang, K. Y.; Li, G.; Zou, X. W.; Chai, Y. S.

    2017-09-01

    This study focused on optimization method of a ceramic proppant material with both low cost and high performance that met the requirements of Chinese Petroleum and Gas Industry Standard (SY/T 5108-2006). The orthogonal experimental design of L9(34) was employed to study the significance sequence of three factors, including weight ratio of white clay to bauxite, dolomite content and sintering temperature. For the crush resistance, both the range analysis and variance analysis reflected the optimally experimental condition was weight ratio of white clay to bauxite=3/7, dolomite content=3 wt.%, temperature=1350°C. For the bulk density, the most important factor was the sintering temperature, followed by the dolomite content, and then the ratio of white clay to bauxite.

  14. Numerical methods to design the flow parts of steam turbines and their experimental testing

    International Nuclear Information System (INIS)

    Valha, J.

    1989-01-01

    In designing new turbines, a mathematical model has to be developed of flow and of thermodynamic parameter behavior. The result is the velocity distribution in the blade channel of a variable thickness, defined by the spacing of the adjoining stream surfaces. Losses due to thermodynamic relaxation are caused by irreversible processes between the steam and the liquid phase. The calculations were experimentally tested on a model of the 200 MW turbine in a scale of 1:5. For the power stage, the experimentally obtained distribution of static pressure on the foot and on the top blading diameter was compared with calculated values. The monochromatic light beam attenuation method was used in measuring the mean diameter of primary droplets at the outlet of the power stage. (M.D.). 4 figs., 1 tab., 16 refs

  15. Micro-Randomized Trials: An Experimental Design for Developing Just-in-Time Adaptive Interventions

    Science.gov (United States)

    Klasnja, Predrag; Hekler, Eric B.; Shiffman, Saul; Boruvka, Audrey; Almirall, Daniel; Tewari, Ambuj; Murphy, Susan A.

    2015-01-01

    Objective This paper presents an experimental design, the micro-randomized trial, developed to support optimization of just-in-time adaptive interventions (JITAIs). JITAIs are mHealth technologies that aim to deliver the right intervention components at the right times and locations to optimally support individuals’ health behaviors. Micro-randomized trials offer a way to optimize such interventions by enabling modeling of causal effects and time-varying effect moderation for individual intervention components within a JITAI. Methods The paper describes the micro-randomized trial design, enumerates research questions that this experimental design can help answer, and provides an overview of the data analyses that can be used to assess the causal effects of studied intervention components and investigate time-varying moderation of those effects. Results Micro-randomized trials enable causal modeling of proximal effects of the randomized intervention components and assessment of time-varying moderation of those effects. Conclusions Micro-randomized trials can help researchers understand whether their interventions are having intended effects, when and for whom they are effective, and what factors moderate the interventions’ effects, enabling creation of more effective JITAIs. PMID:26651463

  16. Microrandomized trials: An experimental design for developing just-in-time adaptive interventions.

    Science.gov (United States)

    Klasnja, Predrag; Hekler, Eric B; Shiffman, Saul; Boruvka, Audrey; Almirall, Daniel; Tewari, Ambuj; Murphy, Susan A

    2015-12-01

    This article presents an experimental design, the microrandomized trial, developed to support optimization of just-in-time adaptive interventions (JITAIs). JITAIs are mHealth technologies that aim to deliver the right intervention components at the right times and locations to optimally support individuals' health behaviors. Microrandomized trials offer a way to optimize such interventions by enabling modeling of causal effects and time-varying effect moderation for individual intervention components within a JITAI. The article describes the microrandomized trial design, enumerates research questions that this experimental design can help answer, and provides an overview of the data analyses that can be used to assess the causal effects of studied intervention components and investigate time-varying moderation of those effects. Microrandomized trials enable causal modeling of proximal effects of the randomized intervention components and assessment of time-varying moderation of those effects. Microrandomized trials can help researchers understand whether their interventions are having intended effects, when and for whom they are effective, and what factors moderate the interventions' effects, enabling creation of more effective JITAIs. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  17. Computational simulations of frictional losses in pipe networks confirmed in experimental apparatusses designed by honors students

    Science.gov (United States)

    Pohlman, Nicholas A.; Hynes, Eric; Kutz, April

    2015-11-01

    Lectures in introductory fluid mechanics at NIU are a combination of students with standard enrollment and students seeking honors credit for an enriching experience. Most honors students dread the additional homework problems or an extra paper assigned by the instructor. During the past three years, honors students of my class have instead collaborated to design wet-lab experiments for their peers to predict variable volume flow rates of open reservoirs driven by gravity. Rather than learn extra, the honors students learn the Bernoulli head-loss equation earlier to design appropriate systems for an experimental wet lab. Prior designs incorporated minor loss features such as sudden contraction or multiple unions and valves. The honors students from Spring 2015 expanded the repertoire of available options by developing large scale set-ups with multiple pipe networks that could be combined together to test the flexibility of the student team's computational programs. The engagement of bridging the theory with practice was appreciated by all of the students such that multiple teams were able to predict performance within 4% accuracy. The challenges, schedules, and cost estimates of incorporating the experimental lab into an introductory fluid mechanics course will be reported.

  18. Preliminary design of lithium lead test blanket module for the Chinese Experimental Advanced Superconducting Tokamak

    International Nuclear Information System (INIS)

    Liu Songlin; Bai Yunqing; Zheng Shanliang; Chen Hongli; Wang Weihua; Long Pengcheng; Wu Yican

    2007-01-01

    The Chinese Experimental Advanced Superconducting Tokamak (EAST) has been successfully constructed and has produced a discharge of plasma in x2006. It aims to achieve static-state operation of high performance D-D plasma with a long pulse of up to 1000 s and may be severed as a valuable pre-testing platform for Test Blanket Module (TBM) prior to International Thermonuclear Experimental Reactor (ITER). Based on the Chinese Dual Function Lithium Lead TBM (DFLL-TBM) design and its testing plan for ITER and EAST, a lithium lead test blanket module concept for the EAST (EAST-TBM) has been proposed as an important R and D activity and is expected to be tested in EAST focusing on electro-magnetics and thermo-mechanics performances of the TBM, including the influence of TBM made of ferromagnetic steel on tokamak plasma. This paper presents the status of EAST-TBM design, including design guideline, main features, instrumentation configuration, and installation in EAST port. The feasibility of the EAST-TBM has been validated with the preliminary performance analyses

  19. Pressure-Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients.

    Science.gov (United States)

    Chopski, Steven G; Fox, Carson S; Riddle, Michelle L; McKenna, Kelli L; Patel, Jay P; Rozolis, John T; Throckmorton, Amy L

    2016-03-01

    An intravascular axial flow pump is being developed as a mechanical cavopulmonary assist device for adolescent and adult patients with dysfunctional Fontan physiology. Coupling computational modeling with experimental evaluation of prototypic designs, this study examined the hydraulic performance of 11 impeller prototypes with blade stagger or twist angles varying from 100 to 600 degrees. A refined range of twisted blade angles between 300 and 400 degrees with 20-degree increments was then selected, and four additional geometries were constructed and hydraulically evaluated. The prototypes met performance expectations and produced 3-31 mm Hg for flow rates of 1-5 L/min for 6000-8000 rpm. A regression analysis was completed with all characteristic coefficients contributing significantly (P designs. The findings of the numerical model for 300-degree twisted case and the experimental results deviated within approximately 20%. In an effort to simplify the impeller geometry, this work advanced the design of this intravascular cavopulmonary assist device closer to preclinical animal testing. Copyright © 2015 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

  20. Conceptual design of beam dividing system for J-PARC Transmutation Experimental Facility

    International Nuclear Information System (INIS)

    Yoshimoto, Masahiro; Okabe, Kota; Kinsho, Michikazu

    2015-01-01

    At the Japan Proton Accelerator Research Complex, a new experimental facility called the Transmutation Experimental Facility (TEF) is planned for the Accelerator-Driven System. The TEF facility will use the 400 MeV proton beam from the LINAC, which requires introducing a beam dividing system at a Beam Transport from the LINAC to the 3 GeV Rapid Cycling Synchrotron (RCS). However, an early feasibility study indicates that sufficient beam orbit separation is difficult to obtain at the doublet with only a pulsed bending magnet. Therefore, the beam for the TEF is extracted by using both the pulsed bending magnet and a static septum magnet. To optimize this two-step beam extraction scheme, the doublet quadrupole magnets should be improved. Moreover, the residual field of the pulse bending magnet at zero current should be corrected. By studying every possible scheme for the beam dividing system under current conditions, we expect to obtain a realistic design for the beam dividing system. In this paper, we introduce a conceptual design of the beam dividing system that is based on resent results of studies of realistic designs. (author)

  1. Experimental and Numerical Design and Optimization of a Counter-Flow Heat Exchanger

    Directory of Open Access Journals (Sweden)

    Bahrami Salman

    2018-01-01

    Full Text Available A new inexpensive counter-flow heat exchanger has been designed and optimized for a vapor-compression cooling system in this research. The main aim is to experimentally and numerically evaluate the effect of an internal heat exchanger (IHX adaptation in an automotive air conditioning system. In this new design of IHX, the high-pressure liquid passes through the central channel and the low-pressure vapor flows in several parallel channels in the opposite direction. The experimental set-up has been made up of original components of the air conditioning system of a medium sedan car, specially designed and built to analyze vehicle A/C equipment under real operating conditions. The results show that this compact IHX may achieve up to 10% of the evaporator capacity while low pressure drop will be imposed on this refrigeration cycle. Also, they confirm considerable decrease of compressor power consumption (CPC, which is intensified at higher evaporator air flow. A significant improvement of the coefficient of performance (COP is achieved with the IHX employment too. The influence of operating conditions has been also discussed in this paper. Finally, numerical analyses have been briefly presented, which bring more details of the flow behavior and heat transfer phenomena, and help to determine the optimal arrangement of channels.

  2. Experimental validation of 3D printed material behaviors and their influence on the structural topology design

    Science.gov (United States)

    Yang, Kai Ke; Zhu, Ji Hong; Wang, Chuang; Jia, Dong Sheng; Song, Long Long; Zhang, Wei Hong

    2018-02-01

    The purpose of this paper is to investigate the structures achieved by topology optimization and their fabrications by 3D printing considering the particular features of material microstructures and macro mechanical performances. Combining Digital Image Correlation and Optical Microscope, this paper experimentally explored the anisotropies of stiffness and strength existing in the 3D printed polymer material using Stereolithography (SLA) and titanium material using Selective Laser Melting (SLM). The standard specimens and typical structures obtained by topology optimization were fabricated along different building directions. On the one hand, the experimental results of these SLA produced structures showed stable properties and obviously anisotropic rules in stiffness, ultimate strengths and places of fractures. Further structural designs were performed using topology optimization when the particular mechanical behaviors of SLA printed materials were considered, which resulted in better structural performances compared to the optimized designs using `ideal' isotropic material model. On the other hand, this paper tested the mechanical behaviors of SLM printed multiscale lattice structures which were fabricated using the same metal powder and the same machine. The structural stiffness values are generally similar while the strength behaviors show a difference, which are mainly due to the irregular surface quality of the tiny structural branches of the lattice. The above evidences clearly show that the consideration of the particular behaviors of 3D printed materials is therefore indispensable for structural design and optimization in order to improve the structural performance and strengthen their practical significance.

  3. Design and experimental characterization of a NiTi-based, high-frequency, centripetal peristaltic actuator

    International Nuclear Information System (INIS)

    Borlandelli, E; Scarselli, D; Bettini, P; Morandini, M; Sala, G; Quadrio, M; Nespoli, A; Rigamonti, D; Villa, E

    2015-01-01

    Development and experimental testing of a peristaltic device actuated by a single shape-memory NiTi wire are described. The actuator is designed to radially shrink a compliant silicone pipe, and must work on a sustained basis at an actuation frequency that is higher than those typical of NiTi actuators. Four rigid, aluminum-made circular sectors are sitting along the pipe circumference and provide the required NiTi wire housing. The aluminum assembly acts as geometrical amplifier of the wire contraction and as heat sink required to dissipate the thermal energy of the wire during the cooling phase. We present and discuss the full experimental investigation of the actuator performance, measured in terms of its ability to reduce the pipe diameter, at a sustained frequency of 1.5 Hz. Moreover, we investigate how the diameter contraction is affected by various design parameters as well as actuation frequencies up to 4 Hz. We manage to make the NiTi wire work at 3% in strain, cyclically providing the designed pipe wall displacement. The actuator performance is found to decay approximately linearly with actuation frequencies up to 4 Hz. Also, the interface between the wire and the aluminum parts is found to be essential in defining the functional performance of the actuator. (paper)

  4. Experimental Investigation of a Point Design Optimized Arrow Wing HSCT Configuration

    Science.gov (United States)

    Narducci, Robert P.; Sundaram, P.; Agrawal, Shreekant; Cheung, S.; Arslan, A. E.; Martin, G. L.

    1999-01-01

    The M2.4-7A Arrow Wing HSCT configuration was optimized for straight and level cruise at a Mach number of 2.4 and a lift coefficient of 0.10. A quasi-Newton optimization scheme maximized the lift-to-drag ratio (by minimizing drag-to-lift) using Euler solutions from FL067 to estimate the lift and drag forces. A 1.675% wind-tunnel model of the Opt5 HSCT configuration was built to validate the design methodology. Experimental data gathered at the NASA Langley Unitary Plan Wind Tunnel (UPWT) section #2 facility verified CFL3D Euler and Navier-Stokes predictions of the Opt5 performance at the design point. In turn, CFL3D confirmed the improvement in the lift-to-drag ratio obtained during the optimization, thus validating the design procedure. A data base at off-design conditions was obtained during three wind-tunnel tests. The entry into NASA Langley UPWT section #2 obtained data at a free stream Mach number, M(sub infinity), of 2.55 as well as the design Mach number, M(sub infinity)=2.4. Data from a Mach number range of 1.8 to 2.4 was taken at UPWT section #1. Transonic and low supersonic Mach numbers, M(sub infinity)=0.6 to 1.2, was gathered at the NASA Langley 16 ft. Transonic Wind Tunnel (TWT). In addition to good agreement between CFD and experimental data, highlights from the wind-tunnel tests include a trip dot study suggesting a linear relationship between trip dot drag and Mach number, an aeroelastic study that measured the outboard wing deflection and twist, and a flap scheduling study that identifies the possibility of only one leading-edge and trailing-edge flap setting for transonic cruise and another for low supersonic acceleration.

  5. Fundamental conceptual design of the experimental multi-purpose high-temperature gas-cooled reactor

    International Nuclear Information System (INIS)

    Shimokawa, Junichi; Yasuno, Takehiko; Yasukawa, Shigeru; Mitake, Susumu; Miyamoto, Yoshiaki

    1975-06-01

    The fundamental conceptual design of the experimental multi-purpose very high-temperature gas-cooled reactor (experimental VHTR of thermal output 50 MW with reactor outlet-gas temperature 1,000 0 C) has been carried out to provide the operation modes of the system consisting of the reactor and the heat-utilization system, including characteristics and performance of the components and safety of the plant system. For the heat-utilization system of the plant, heat distribution, temperature condition, cooling system constitution, and the containment facility are specified. For the operation of plant, testing capability of the reactor and controlability of the system are taken into consideration. Detail design is made of the fuel element, reactor core, reactivity control and pressure vessel, and also the heat exchanger, steam reformer, steam generator, helium circulator, helium-gas turbine, and helium-gas purification, fuel handling, and engineered safety systems. Emphasis is placed on providing the increase of the reactor outlet-gas temperature. Fuel element design is directed to the prismatic graphite blocks of hexagonal cross-section accommodating the hollow or tubular fuel pins sheathed in graphite sleeve. The reactor core is composed of 73 fuel columns in 7 stages, concerning the reference design MK-II. Orificing is made in the upper portion of core; one orifice for every 7 fuel columns. Average core power density is 2.5 watts/cm 3 . Fuel temperature is kept below 1,300 0 C in rated power. The main components, i.e. pressure vessel, reformer, gas turbine and intermediate heat exchanger are designed in detail; the IHX is of a double-shell and helically-wound tube coils, the reformer is of a byonet tube type, and the turbine-compressor unit is of an axial flow type (turbine in 6 stages and compressor in 16 stages). (auth.)

  6. ENGINEERING DESIGN OPTIMIZATION OF HEEL TESTING EQUIPMENT IN THE EXPERIMENTAL VALIDATION OF SAFE WALKING

    Directory of Open Access Journals (Sweden)

    Cristiano Fragassa

    2017-06-01

    Full Text Available Experimental test methods for the evaluation of the resistance of heels of ladies' shoes in the case of impact loads are fully defined by International Organization for Standardization (ISO procedures that indicate all the conditions of experiment. A first Standard (ISO 19553 specifies the test method for determining the strength of the heels in the case of single impact. The result offers a valuation of the liability to fail under the sporadic heavy blows. A second Standard (ISO 19556 details a method for testing the capability of heels of women' shoes to survive to the repetition of small impacts provoked by normal walking. These Standards strictly define the features for two different testing devices (with specific materials, geometries, weights, etc. and all the experimental procedures to be followed during tests. On the contrary, this paper describes the technical solutions adopted to design one single experimental device able to perform impact testing of heels in both conditions. Joining the accuracy of mechanic movements with the speed of an electronic control system, a new and flexible equipment for the complete characterization of heels respect to (single or fatigue impacts was developed. Moreover a new level of performances in experimental validation of heel resistance was introduced by the versatility of the user-defined software control programs, able to encode every complex time-depending cycle of impact loads. Dynamic simulations permitted to investigate the impacts on heel in different conditions of testing, optimizing the machine design. The complexity of real stresses on shoes during an ordinary walk and in other common situations (as going up and downstairs was considered for a proper dimensioning.

  7. Experimental characterization and multidisciplinary conceptual design optimization of a bendable load stiffened unmanned air vehicle wing

    Science.gov (United States)

    Jagdale, Vijay Narayan

    Demand for deployable MAVs and UAVs with wings designed to reduce aircraft storage volume led to the development of a bendable wing concept at the University of Florida (UF). The wing shows an ability to load stiffen in the flight load direction, still remaining compliant in the opposite direction, enabling UAV storage inside smaller packing volumes. From the design prospective, when the wing shape parameters are treated as design variables, the performance requirements : high aerodynamic efficiency, structural stability under aggressive flight loads and desired compliant nature to prevent breaking while stored, in general conflict with each other. Creep deformation induced by long term storage and its effect on the wing flight characteristics are additional considerations. Experimental characterization of candidate bendable UAV wings is performed in order to demonstrate and understand aerodynamic and structural behavior of the bendable load stiffened wing under flight loads and while the wings are stored inside a canister for long duration, in the process identifying some important wing shape parameters. A multidisciplinary, multiobjective design optimization approach is utilized for conceptual design of a 24 inch span and 7 inch root chord bendable wing. Aerodynamic performance of the wing is studied using an extended vortex lattice method based Athena Vortex Lattice (AVL) program. An arc length method based nonlinear FEA routine in ABAQUS is used to evaluate the structural performance of the wing and to determine maximum flying velocity that the wing can withstand without buckling or failing under aggressive flight loads. An analytical approach is used to study the stresses developed in the composite wing during storage and Tsai-Wu criterion is used to check failure of the composite wing due to the rolling stresses to determine minimum safe storage diameter. Multidisciplinary wing shape and layup optimization is performed using an elitist non-dominated sorting

  8. Experimental on-line platform for product conceptual design: OpenDesigNet

    Directory of Open Access Journals (Sweden)

    Teresa Magal-Royo

    2013-09-01

    Full Text Available This paper highlights the need for using specialised on-line collaborative environments by designers and product engineers who increasingly use Web 2.0 technology to search for information. Although there are professional channels and networks, there is no specific platform which helps during a new product’s conceptualisation phase. Open communication must thus be promoted and encouraged amongst design professionals and companies to form working groups thereby allowing them to work collaboratively in the most open and creative phase of product design, i.e. conceptualisation. The OpenDesigNet (ODN experimental platform has been developed so that designers and small- or medium-sized companies (SMC can access on-line collaborative tools to support the creation and promotion of new on-line products and assess their immediate social impact. This article presents some of the results obtained during the validation phase involving a platform satisfaction survey of design engineering students and has led to a first-hand assessment of the new platform’s potential impact on their professional future.

  9. Design study of superconducting toroidal magnet for tokamak experimental fusion reactor

    International Nuclear Information System (INIS)

    1977-10-01

    Design study of the superconducting toroidal magnet for the Tokamak experimental fusion reactor has been carried out. Performed here were conductor design, magnetic field calculation, design of coil support, stress analysis, design of refrigeration system and safety analysis. The maximum toroidal field at the coil is 12.0 T, providing 6.0 T at the plasma center. The coil bore is 7.3 x 11.2 m, and the coil shape is deformed constant-tension D-shape. 16 coil design was chosen, considering the necessity for good access for the evacuation port or the support structure of blanket and shield. The maximum field ripple obtained in the plasma region is 0.47%. The operational current is 25,100 amperes, and the cryogenic stabilization is fulfilled. Nb 3 Sn superconductor was chosen in spite of its brittleness, to attain a toroidal field of 12 T which is higher than a practical limit for NbTi superconductor. The development of large Nb 3 Sn coil technology would be necessary to realize an economic fusion power reactor. (auth.)

  10. Experimental facility design for study of fretting in steam generator tubes

    International Nuclear Information System (INIS)

    Balbiani, J.P.; Bergant, M.; Yawny, A.

    2012-01-01

    The design of an experimental facility for fretting wear testing of steam generator tubes under pressurized water up to 340 o C, is presented. The main component of the device consists in an autoclave which permits to recreate steam generator operating conditions. CAD CATIA V5R18, CAE ABAQUS and ASME Sec. VII Div. 1 (Rules for Construction of Pressure Vessels) were used along the design process. The design of the autoclave included the pressure vessel itself and the necessary flanges and nozzles. In addition, an axial dynamic sealing system was designed to allow for actuation from outside the pressure boundary. Complementary, typical tube - support contact conditions were analyzed and the principal variables affecting their mutual interaction determined. In addition, a simple device which allows performing fretting wear testing on steam generator tubes in air at room temperature was fabricated and the feasibility of a quantitative assessment of different aspects related with the fretting induced damage was explored. Characterization techniques available at Centro Atomico Bariloche, like light microscopy, scanning electron microscopy (SEM), energy dispersive analysis of X-ray (EDAX) and surface damage analysis by optic profilometry were shown to be appropriate for this aim. The designed facility will allow evaluating fretting damage of tubes - support combinations that might be used on the steam generator of the prototype reactor CAREM-25. It is also expected it could be applied to characterize fretting severity in other applications (nuclear fuel elements) (author)

  11. Experimental and numerical validation of a two-region-designed pebble bed reactor with dynamic core

    International Nuclear Information System (INIS)

    Jiang, S.Y.; Yang, X.T.; Tang, Z.W.; Wang, W.J.; Tu, J.Y.; Liu, Z.Y.; Li, J.

    2012-01-01

    Highlights: ► The experimental installation has been built to investigate the pebble flow. ► The feasibility of two-region pebble bed reactor has been verified. ► The pebble flow is more uniform in a taller vessel than that in a lower vessel. ► Larger base cone angle will decrease the scale of the stagnant zone. - Abstract: The pebble flow is the principal issue for the design of the pebble bed reactor. In order to verify the feasibility of a two-region-designed pebble bed reactor, the experimental installation with a taller vessel has been built, which is proportional to the real pebble bed reactor. With the aid of the experimental installation, the stable establishment and maintenance of the two-region arrangement has been verified, at the same time, the applicability of the DEM program has been also validated. Research results show: (1) The pebble's bouncing on the free surface is an important factor for the mixing of the different colored pebbles. (2) Through the guide plates installed in the top of the pebble packing, the size of the mixing zone can be reduced from 6–7 times to 3–4 times the pebble diameter. (3) The relationship between the width of the central region and the ratio of loading pebbles is approximately linear in the taller vessel. (4) The heighten part of the pebble packing can improve the uniformity of the flowing in the lower. (5) To increase the base cone angle can decrease the scale of the stagnant zone. All of these conclusions are meaningful to the design of the real pebble reactor.

  12. Coal Recycling from Tailings using Flotation with 2-Level Experimental Design Techniques

    Directory of Open Access Journals (Sweden)

    Sajjad Jannesar Malakooti

    2012-12-01

    Full Text Available In this study, the possibility of producing coal with less than 11% ash from tailings of flotation process was investigated. The effect of six flotation parameters: collector type, collector consumption, frother type, frother consumption, pulp density and mixing rate were studied on a sample from a tailing dam. A software based experimental design approach (DX7 was applied to determine and model effective parameters as well as flotation optimization through fractional factorial. It was shown that collector type and flotation machine mixing rate were the most effective parameters on ash content of concentrate. The results indicated that the production of a desired ash content concentrate, i.e.

  13. Application of experimental design in geothermal resources assessment of Ciwidey-Patuha, West Java, Indonesia

    Science.gov (United States)

    Ashat, Ali; Pratama, Heru Berian

    2017-12-01

    The successful Ciwidey-Patuha geothermal field size assessment required integration data analysis of all aspects to determined optimum capacity to be installed. Resources assessment involve significant uncertainty of subsurface information and multiple development scenarios from these field. Therefore, this paper applied the application of experimental design approach to the geothermal numerical simulation of Ciwidey-Patuha to generate probabilistic resource assessment result. This process assesses the impact of evaluated parameters affecting resources and interacting between these parameters. This methodology have been successfully estimated the maximum resources with polynomial function covering the entire range of possible values of important reservoir parameters.

  14. Experimental Design for CMIP6: Aerosol, Land Use, and Future Scenarios Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Arnott, James [AGCI

    2015-10-30

    The Aspen Global Change Institute hosted a technical science workshop entitled, “Experimental design for CMIP6: Aerosol, Land Use, and Future Scenarios,” on August 3-8, 2014 in Aspen, CO. Claudia Tebaldi (NCAR) and Brian O’Neill (NCAR) served as co-chairs for the workshop. The Organizing committee also included Dave Lawrence (NCAR), Jean-Francois Lamarque (NCAR), George Hurtt (University of Maryland), & Detlef van Vuuren (PBL Netherlands Environmental Change). The meeting included the participation of 22 scientists representing many of the major climate modeling centers for a total of 110 participant days.

  15. Study of a 5 kW PEMFC using experimental design and statistical analysis techniques

    Energy Technology Data Exchange (ETDEWEB)

    Wahdame, B.; Francois, X.; Kauffmann, J.M. [Laboratory of Electrical Engineering and Systems (L2ES), Unite mixte de recherche UTBM and UFC - EA 3898, L2ES-UTBM Batiment F, rue Thierry Mieg, 90010 BELFORT Cedex (France); Candusso, D.; Harel, F.; De Bernardinis, A.; Coquery, G. [The French National Institute for Transport and Safety Research (INRETS), 2 avenue du General Malleret-Joinville, 94 114 ARCUEIL Cedex (France)

    2007-02-15

    Within the framework of the French inter lab SPACT project (Fuel Cell Systems for Transportation Applications), the behavior of a 5 kW PEM fuel cell stack, fed by humidified hydrogen and compressed air, is investigated in a test platform at Belfort, France. A set of polarization curves are recorded, under various conditions of stack temperature, gas pressure, and stoichiometry rates, in order to obtain a kind of cartography, representing the static stack performance. Initially, the tests are defined considering experimental design techniques. In order to study the relative impacts of the physical factors on the fuel cell voltage, some polarization curve results are selected from the static tests available applying experimental design methodology. First, several analyses are used to estimate the impact of the stack temperature, gas pressure, and stoichiometry rate on the fuel cell voltage. Statistical sensitivity analyses (ANOVA) are used to compute, from the available data, the effects and respective contributions of the various physical factors on the stack voltage. The potential for the detection of any interactions between the different parameters is shown. Also, some graphic representations are used to display the results of the statistical analyses made for different current values of the polarization curves. Then, the experimental design method and its associated statistical tools are employed in order to identify the influence of the stack temperature and gas pressure on the fuel cell voltage. Moreover, it is shown how it is possible to reduce the number of experiments needed and how certain optimizations of the fuel cell operating parameters leading to higher performances can be achieved. The work presented aims at showing the suitability of the experimental design method for the characterization, analysis, and improvement of a complex system like a fuel cell generator. The future outlook is proposed in the final part of the paper. The methodologies

  16. Calibration of an experimental model of tritium storage bed designed for 'in situ' accountability

    International Nuclear Information System (INIS)

    Bidica, Nicolae; Stefanescu, Ioan; Bucur, Ciprian; Bulubasa, Gheorghe; Deaconu, Mariea

    2009-01-01

    Full text: Objectives: Tritium accountancy of the storage beds in tritium facilities is an important issue for tritium inventory control. The purpose of our work was to perform calibration of an experimental model of tritium storage bed with a special design, using electric heaters to simulate tritium decay, and to evaluate the detection limit of the accountancy method. The objective of this paper is to present an experimental method used for calibration of the storage bed and the experimental results consisting of calibration curves and detection limit. Our method is based on a 'self-assaying' tritium storage bed. The basic characteristics of the design of our storage bed consists, in principle, of a uniform distribution of the storage material on several copper thin fins (in order to obtain a uniform temperature field inside the bed), an electrical heat source to simulate the tritium decay heat, a system of thermocouples for measuring the temperature field inside the bed, and good thermal isolation of the bed from the external environment. Within this design of the tritium storage bed, the tritium accounting method is based on determining the decay heat of tritium by measuring the temperature increase of the isolated storage bed. Experimental procedure consisted in measuring of temperature field inside the bed for few values of the power injected with the aid of electrical heat source. Data have been collected for few hours and the temperature increase rate was determined for each value of the power injected. Graphical representation of temperature rise versus injected powers was obtained. This accounting method of tritium inventory stored as metal tritide is a reliable solution for in-situ tritium accountability in a tritium handling facility. Several improvements can be done regarding the design of the storage bed in order to improve the measurement accuracy and to obtain a lower detection limit as for instance use of more accurate thermocouples or special

  17. The Pliocene Model Intercomparison Project (PlioMIP) Phase 2: Scientific objectives and experimental design

    Science.gov (United States)

    Haywood, Alan M.; Dowsett, Harry J.; Dolan, Aisling M.; Rowley, David; Abe-Ouchi, Ayako; Otto-Bliesner, Bette; Chandler, Mark A.; Hunter, Stephen J.; Lunt, Daniel J.; Pound, Matthew; Salzmann, Ulrich

    2016-01-01

    The Pliocene Model Intercomparison Project (PlioMIP) is a co-ordinated international climate modelling initiative to study and understand climate and environments of the Late Pliocene, as well as their potential relevance in the context of future climate change. PlioMIP examines the consistency of model predictions in simulating Pliocene climate and their ability to reproduce climate signals preserved by geological climate archives. Here we provide a description of the aim and objectives of the next phase of the model intercomparison project (PlioMIP Phase 2), and we present the experimental design and boundary conditions that will be utilized for climate model experiments in Phase 2. 

  18. Design and adjustment on test bed of replacing subassembly machine control system for China experimental fast reactor

    International Nuclear Information System (INIS)

    Dong Shengguo; Ma Hongsheng; Zhao Lixia

    2008-01-01

    The present research concerns in the design and adjustment of replacing sub- assembly machine control system of China Experimental Fast Reactor. The design of replacing subassembly machine control system adopts some electric equipments, such as programmable controllers, digital DC drivers. The designed control system was adjusted on the test bed. The results indicate that the operation of the control system is steady and reliable, and designed control system can meet the needs of the design specification. (authors)

  19. The Dynamic Similitude Design Method of Thin Walled Structures and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Zhong Luo

    2016-01-01

    Full Text Available For the applicability of dynamic similitude models of thin walled structures, such as engine blades, turbine discs, and cylindrical shells, the dynamic similitude design of typical thin walled structures is investigated. The governing equation of typical thin walled structures is firstly unified, which guides to establishing dynamic scaling laws of typical thin walled structures. Based on the governing equation, geometrically complete scaling law of the typical thin walled structure is derived. In order to determine accurate distorted scaling laws of typical thin walled structures, three principles are proposed and theoretically proved by combining the sensitivity analysis and governing equation. Taking the thin walled annular plate as an example, geometrically complete and distorted scaling laws can be obtained based on the principles of determining dynamic scaling laws. Furthermore, the previous five orders’ accurate distorted scaling laws of thin walled annular plates are presented and numerically validated. Finally, the effectiveness of the similitude design method is validated by experimental annular plates.

  20. Experimental design of mixture applied to study PVP hydrogels properties crosslinked by ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Alcantara, Mara Tania S.; Lugao, Ademar B., E-mail: maratalcantara@uol.com.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Taqueda, Maria Elena S. [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica. Dept. de Engenharia Quimica

    2009-07-01

    Hydrogels are three dimensional hydrophilic crosslinked polymeric networks that have capacity to swell by absorbing water or biological fluids without dissolve. Hydrogels have been widely used in different application fields from agriculture, industry and in biomedicine. The properties of a hydrogel are extremely important in selecting which materials are suitable for a specific application. So mixtures can offer hydrogels with different properties to different applications. The PVP hydrogels were prepared by gamma radiation of an aqueous polymer solution and crosslinked by gamma ray, an effective and simple method for hydrogel formation that offers some advantages over the other techniques. In this work, a mixture experimental design was used to study the relationship between polymer cross-linking and swelling properties of PVP hydrogels with PEG as plasticizer and agar as gellifier. The gel fraction was measured for every mixture specified for the experiment D-optimal designs. (author)

  1. Experimental design and multicriteria decision making methods for the optimization of ice cream composition

    Directory of Open Access Journals (Sweden)

    Cristian Rojas

    2012-03-01

    Full Text Available The aim of the present work was to optimize the sensorial and technological features of ice cream. The experimental work was performed in two stages: 1 optimization of lactose enzymatic hydrolysis, and 2 optimization of the process and product. For the first stage a complete factorial design was developed, optimized using both response surface and the steepest ascent method. In the second stage a mixture design was performed, combining the process variables. The product with the best sensorial acceptance, high yield and low cost was selected. The acceptance of the product was developed by an untrained taster’s panel. As a main result the sensorial and technological features of the final product were improved, establishing the optimum parameters for its elaboration.

  2. System engineering and design of a pulsed homopolar generator power supply for the Texas Experimental Tokamak

    International Nuclear Information System (INIS)

    Bird, W.L.; Grant, G.B.; Weldon, W.F.; Rylander, H.G.; Woodson, H.H.

    1977-01-01

    The design of a homopolar generator power supply for the Texas Experimental Tokamak (TEXT) is presented. Four series-connected disk type homopolar machines serve as inertial energy storage and conversion devices to supply 50 to 70 MW peak power to the toroidal field coil and ohmic heating coil circuits. The system is nominally operated at 150 MJ, 430 V to provide a 0.5 sec flat top, 160 kA TF current pulse and a 0.3 sec, 10 kA OH current pulse every 2.0 min on a continuous basis. The system has a maximum capacity of 200 MJ at a maximum open circuit voltage of 500 V. The homopolar machine design is described

  3. Modeling the adsorption of dyes onto activated carbon by using experimental designs.

    Science.gov (United States)

    Gómez, Verónica; Callao, M Pilar

    2008-10-19

    We used experimental design methodologies to obtain the response surface of the adsorption process for three acid dyes used in the dyeing step of a tanning process. The dyes were Acid Red 97, Acid Orange 61 and Acid Brown 425. The adsorption process was evaluated determining the concentrations of individual and total dyes remaining in solution at the end of the process. These concentrations were determined simultaneously in a single step using sequential injection analysis with multivariate curve resolution alternating least squares (SIA-MCR-ALS). This method involves fractional factorial designs and the steepest ascent method to find a zone of efficient adsorption and a response surface-modeling step to fit the relevant adsorption factors for the response.

  4. LASL experimental engineered waste burial facility: design considerations and preliminary plan

    International Nuclear Information System (INIS)

    DePoorter, G.L.

    1980-01-01

    The LASL Experimental Engineered Waste Burial Facility is a part of the National Low-Level Waste Management Program on Shallow-Land Burial Technology. It is a test facility where basic information can be obtained on the processes that occur in shallow-land burial operations and where new concepts for shallow-land burial can be tested on an accelerated basis on an appropriate scale. The purpose of this paper is to present some of the factors considered in the design of the facility and to present a preliminary description of the experiments that are initially planned. This will be done by discussing waste management philosophies, the purposes of the facility in the context of the waste management philosophy for the facility, and the design considerations, and by describing the experiments initially planned for inclusion in the facility, and the facility site

  5. Saphenous artery-based flap models in rats: new flap designs for experimental studies.

    Science.gov (United States)

    Aksam, Ersin; Aksam, Berrak; Demirseren, Mustafa Erol; Yavuz, Huban Sibel Orhun

    2016-12-01

    Experimental research using laboratory animals provides substantial data about reconstructive surgery. However, the literature does not include any experimental studies that have used flap models on the hind limbs of rats. To gain an understanding of the physiology of lower-extremity flaps and of flap failures, this study assessed the cutaneous perforators of the saphenous artery, and new flap models were designed for the hind limbs of rats. The experiment was designed to include three stages and used 35 rats. The first stage involved mapping the perforators of the saphenous artery. In the second stage, the contents and structures of McFarlane, epigastric, and anterior hind limb flap tissues were compared histologically. The third stage of the study involved designing and comparing different flaps for the hind limbs of the rats and included random flaps, perforator-based peninsular flaps, perforator-based island flaps, and perforator-based flaps with rotated pedicles. Postoperative necrosis ratios were evaluated using computer-based software. Mapping of the saphenous artery perforators revealed an average of 2.2 septocutaneous arteries in each hind limb. Histologic studies showed thick dermis and panniculus carnosus in the McFarlane flaps, thick dermis, and thin panniculus carnosus layers in the epigastric flaps, and thin subcutaneous tissue with no panniculus carnosus tissue in the skin of the hind limbs. The results of the flap studies that used random flaps showed a 52.4% necrosis, while there was no necrosis when perforator-based peninsular flaps, island flaps, and flaps with rotated pedicles were used. New flap models used on the saphenous artery perforators of the hind limbs of rats can provide valuable information about the physiology of lower-extremity flaps. New studies can also be designed based on these flap models to acquire more knowledge about pathologic conditions such as ischemia and venous insufficiency. Copyright © 2016 Elsevier Inc. All rights

  6. Potential for Ammonia Recapture by Farm Woodlands: Design and Application of a New Experimental Facility

    Directory of Open Access Journals (Sweden)

    Mark R. Theobald

    2001-01-01

    Full Text Available There has been increasing pressure on farmers in Europe to reduce the emissions of ammonia from their land. Due to the current financial climate in which farmers have to operate, it is important to identify ammonia control measures that can be adopted with minimum cost. The planting of trees around farmland and buildings has been identified as a potentially effective and low-cost measure to enhance ammonia recapture at a farm level and reduce long-range atmospheric transport. This work assesses experimentally what fraction of ammonia farm woodlands could potentially remove from the atmosphere. We constructed an experimental facility in southern Scotland to simulate a woodland shelterbelt planted in proximity to a small poultry unit. By measuring horizontal and vertical ammonia concentration profiles within the woodland, and comparing this to the concentration of an inert tracer (SF6 we estimate the depletion of ammonia due to dry deposition to the woodland canopy. Together with measurements of mean ammonia concentrations and throughfall fluxes of nitrogen, this information is used to provide a first estimate of the fraction of emitted ammonia that is recaptured by the woodland canopy. Analysis of these data give a lower limit of recapture of emitted ammonia, at the experimental facility, of 3%. By careful design of shelterbelt woodlands this figure could be significantly higher.

  7. Experimental design, modeling and optimization of polyplex formation between DNA oligonucleotides and branched polyethylenimine.

    Science.gov (United States)

    Clima, Lilia; Ursu, Elena L; Cojocaru, Corneliu; Rotaru, Alexandru; Barboiu, Mihail; Pinteala, Mariana

    2015-09-28

    The complexes formed by DNA and polycations have received great attention owing to their potential application in gene therapy. In this study, the binding efficiency between double-stranded oligonucleotides (dsDNA) and branched polyethylenimine (B-PEI) has been quantified by processing of the images captured from the gel electrophoresis assays. The central composite experimental design has been employed to investigate the effects of controllable factors on the binding efficiency. On the basis of experimental data and the response surface methodology, a multivariate regression model has been constructed and statistically validated. The model has enabled us to predict the binding efficiency depending on experimental factors, such as concentrations of dsDNA and B-PEI as well as the initial pH of solution. The optimization of the binding process has been performed using simplex and gradient methods. The optimal conditions determined for polyplex formation have yielded a maximal binding efficiency close to 100%. In order to reveal the mechanism of complex formation at the atomic-scale, a molecular dynamic simulation has been carried out. According to the computation results, B-PEI amine hydrogen atoms have interacted with oxygen atoms from dsDNA phosphate groups. These interactions have led to the formation of hydrogen bonds between macromolecules, stabilizing the polyplex structure.

  8. Efficient experimental design of high-fidelity three-qubit quantum gates via genetic programming

    Science.gov (United States)

    Devra, Amit; Prabhu, Prithviraj; Singh, Harpreet; Arvind; Dorai, Kavita

    2018-03-01

    We have designed efficient quantum circuits for the three-qubit Toffoli (controlled-controlled-NOT) and the Fredkin (controlled-SWAP) gate, optimized via genetic programming methods. The gates thus obtained were experimentally implemented on a three-qubit NMR quantum information processor, with a high fidelity. Toffoli and Fredkin gates in conjunction with the single-qubit Hadamard gates form a universal gate set for quantum computing and are an essential component of several quantum algorithms. Genetic algorithms are stochastic search algorithms based on the logic of natural selection and biological genetics and have been widely used for quantum information processing applications. We devised a new selection mechanism within the genetic algorithm framework to select individuals from a population. We call this mechanism the "Luck-Choose" mechanism and were able to achieve faster convergence to a solution using this mechanism, as compared to existing selection mechanisms. The optimization was performed under the constraint that the experimentally implemented pulses are of short duration and can be implemented with high fidelity. We demonstrate the advantage of our pulse sequences by comparing our results with existing experimental schemes and other numerical optimization methods.

  9. Design of the ITER (International Thermonuclear Experimental Reactor) neutral beam system beamline, United States concept

    International Nuclear Information System (INIS)

    Purgalis, P.; Anderson, O.A.; Cooper, W.S.; DeVries, G.E.; Lietzke, A.F.; Kunkel, W.B.; Kwan, J.W.; Matuk, C.A.; Nakai, T.; Stearns, J.W.; Soroka, L.; Wells, R.P.; Lindquist, W.B.; Neef, W.S.; Reginato, L.L.; Sedgley, D.W.; Brook, J.W.; Luzzi, T.E.; Myers, T.J.

    1989-01-01

    Design of a neutral beamline for ITER (International Thermonuclear Experimental Reactor) is described. The design incorporates a barium surface conversion D - source feeding a linear array of accelerator channels. The system uses a dc accelerator with electrostatic quadrupoles for strong focusing. A high voltage power supply that is integrated with the accelerator is presented as an attractive option. A gas neutralizer is used and residual ions exiting the neutralizer are deflected to watercooled dumps. Cryopanels are located at the accelerator exit to pump excess gas from the source and the neutralizer, and in the ion dump cavity to pump re-neutralized ions and neutralizer gas. All the above components are packaged in compact identical, independent modules that can be removed for remote maintenance. The neutral beam system delivers 75 MW of D degree into three ports with a total of nine modules arranged in stacks of three modules per port. To increase reliability each module is designed to deliver up to 10 MW at 1.3 MeV; this allows eight modules operating at partial capacity to deliver the required power in the event one module is removed from service. Radiation protection is provided by shielding and by locating critical components in the source and accelerator 35 m from the port into the torus. Neutron shielding in the drift duct provides the added feature of limiting conductance and thus reducing gas flow to and from the torus. Alternative component choices are also discussed for the evolving design. 8 refs., 4 figs., 1 tab

  10. The emergence of modern statistics in agricultural science: analysis of variance, experimental design and the reshaping of research at Rothamsted Experimental Station, 1919-1933.

    Science.gov (United States)

    Parolini, Giuditta

    2015-01-01

    During the twentieth century statistical methods have transformed research in the experimental and social sciences. Qualitative evidence has largely been replaced by quantitative results and the tools of statistical inference have helped foster a new ideal of objectivity in scientific knowledge. The paper will investigate this transformation by considering the genesis of analysis of variance and experimental design, statistical methods nowadays taught in every elementary course of statistics for the experimental and social sciences. These methods were developed by the mathematician and geneticist R. A. Fisher during the 1920s, while he was working at Rothamsted Experimental Station, where agricultural research was in turn reshaped by Fisher's methods. Analysis of variance and experimental design required new practices and instruments in field and laboratory research, and imposed a redistribution of expertise among statisticians, experimental scientists and the farm staff. On the other hand the use of statistical methods in agricultural science called for a systematization of information management and made computing an activity integral to the experimental research done at Rothamsted, permanently integrating the statisticians' tools and expertise into the station research programme. Fisher's statistical methods did not remain confined within agricultural research and by the end of the 1950s they had come to stay in psychology, sociology, education, chemistry, medicine, engineering, economics, quality control, just to mention a few of the disciplines which adopted them.

  11. Online optimal experimental re-design in robotic parallel fed-batch cultivation facilities.

    Science.gov (United States)

    Cruz Bournazou, M N; Barz, T; Nickel, D B; Lopez Cárdenas, D C; Glauche, F; Knepper, A; Neubauer, P

    2017-03-01

    We present an integrated framework for the online optimal experimental re-design applied to parallel nonlinear dynamic processes that aims to precisely estimate the parameter set of macro kinetic growth models with minimal experimental effort. This provides a systematic solution for rapid validation of a specific model to new strains, mutants, or products. In biosciences, this is especially important as model identification is a long and laborious process which is continuing to limit the use of mathematical modeling in this field. The strength of this approach is demonstrated by fitting a macro-kinetic differential equation model for Escherichia coli fed-batch processes after 6 h of cultivation. The system includes two fully-automated liquid handling robots; one containing eight mini-bioreactors and another used for automated at-line analyses, which allows for the immediate use of the available data in the modeling environment. As a result, the experiment can be continually re-designed while the cultivations are running using the information generated by periodical parameter estimations. The advantages of an online re-computation of the optimal experiment are proven by a 50-fold lower average coefficient of variation on the parameter estimates compared to the sequential method (4.83% instead of 235.86%). The success obtained in such a complex system is a further step towards a more efficient computer aided bioprocess development. Biotechnol. Bioeng. 2017;114: 610-619. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  12. Experimental assessment of level pool routing in preliminary design of floodplain storage.

    Science.gov (United States)

    De Martino, Giuseppe; De Paola, Francesco; Fontana, Nicola; Marini, Gustavo; Ranucci, Antonio

    2012-02-01

    Among control structures in flood management, floodplain storage represents one of the most effective measures, since it holds part of flood volume in a delimited area thus reducing the peak discharge. Sizing of floodplain storage, both on-stream and off-stream, is complex and several methodologies for preliminary design are available in literature, almost all assuming level pool reservoir routing, i.e. the water level in the floodplain is horizontal during the storage filling. Few studies examine the accuracy of that assumption. The present paper work reports an extensive experimental investigation to assess the reliability of level pool routing in the design of on-stream floodplain storages. The good agreement between numerical and experimental values during the filling phase confirmed the reliability of the hypothesis in the preliminary sizing of on-stream floodplain storage. In contrast, even significant differences can be shown during the floodplain draining, due to vegetation and bottom irregularities. Copyright © 2011 Elsevier B.V. All rights reserved.

  13. Design, modeling and experimental investigation of a magnetically coupled flextensional rotation energy harvester

    Science.gov (United States)

    Zou, Hong-Xiang; Zhang, Wen-Ming; Li, Wen-Bo; Gao, Qiu-Hua; Wei, Ke-Xiang; Peng, Zhi-Ke; Meng, Guang

    2017-11-01

    Energy can be harvested from rotational motion for powering wireless autonomous electronic devices. In this paper, a novel magnetically coupled flextensional rotation energy harvester (MF-REH) is designed, with the advantages of high equivalent piezoelectric constant and high reliability. The coupled dynamical model is developed to describe the electromechanical transition. Effects of design parameters on rotation energy harvesting are analyzed. Simulations and experiments are carried out to evaluate the performances of the harvesters with various configurations under different rotating speeds. The experimental results verify that the developed mathematical model can be used to accurately characterize the MF-REHs with various configurations, in different conditions under various excitation. The experimental results indicate more excitation magnets and smaller excitation distance can significantly increase the harvested energy. For the harvester with one magnetically coupled flextensional transducer and two rotating magnets which produce repulsive forces, the maximum instantaneous power is 3.1 mW and the average power is 0.22 mW at 1000 rpm.

  14. Model Development and Experimental Validation of the Fusible Heat Sink Design for Exploration Vehicles

    Science.gov (United States)

    Cognata, Thomas J.; Leimkuehler, Thomas; Sheth, Rubik; Le, Hung

    2013-01-01

    The Fusible Heat Sink is a novel vehicle heat rejection technology which combines a flow through radiator with a phase change material. The combined technologies create a multi-function device able to shield crew members against Solar Particle Events (SPE), reduce radiator extent by permitting sizing to the average vehicle heat load rather than to the peak vehicle heat load, and to substantially absorb heat load excursions from the average while constantly maintaining thermal control system setpoints. This multi-function technology provides great flexibility for mission planning, making it possible to operate a vehicle in hot or cold environments and under high or low heat load conditions for extended periods of time. This paper describes the modeling and experimental validation of the Fusible Heat Sink technology. The model developed was intended to meet the radiation and heat rejection requirements of a nominal MMSEV mission. Development parameters and results, including sizing and model performance will be discussed. From this flight-sized model, a scaled test-article design was modeled, designed, and fabricated for experimental validation of the technology at Johnson Space Center thermal vacuum chamber facilities. Testing showed performance comparable to the model at nominal loads and the capability to maintain heat loads substantially greater than nominal for extended periods of time.

  15. Supersonic Retro-Propulsion Experimental Design for Computational Fluid Dynamics Model Validation

    Science.gov (United States)

    Berry, Scott A.; Laws, Christopher T.; Kleb, W. L.; Rhode, Matthew N.; Spells, Courtney; McCrea, Andrew C.; Truble, Kerry A.; Schauerhamer, Daniel G.; Oberkampf, William L.

    2011-01-01

    The development of supersonic retro-propulsion, an enabling technology for heavy payload exploration missions to Mars, is the primary focus for the present paper. A new experimental model, intended to provide computational fluid dynamics model validation data, was recently designed for the Langley Research Center Unitary Plan Wind Tunnel Test Section 2. Pre-test computations were instrumental for sizing and refining the model, over the Mach number range of 2.4 to 4.6, such that tunnel blockage and internal flow separation issues would be minimized. A 5-in diameter 70-deg sphere-cone forebody, which accommodates up to four 4:1 area ratio nozzles, followed by a 10-in long cylindrical aftbody was developed for this study based on the computational results. The model was designed to allow for a large number of surface pressure measurements on the forebody and aftbody. Supplemental data included high-speed Schlieren video and internal pressures and temperatures. The run matrix was developed to allow for the quantification of various sources of experimental uncertainty, such as random errors due to run-to-run variations and bias errors due to flow field or model misalignments. Some preliminary results and observations from the test are presented, although detailed analyses of the data and uncertainties are still on going.

  16. Design and Experimental Evolution of trans-Splicing Group I Intron Ribozymes

    Directory of Open Access Journals (Sweden)

    Ulrich F. Müller

    2017-01-01

    Full Text Available Group I intron ribozymes occur naturally as cis-splicing ribozymes, in the form of introns that do not require the spliceosome for their removal. Instead, they catalyze two consecutive trans-phosphorylation reactions to remove themselves from a primary transcript, and join the two flanking exons. Designed, trans-splicing variants of these ribozymes replace the 3′-portion of a substrate with the ribozyme’s 3′-exon, replace the 5′-portion with the ribozyme’s 5′-exon, or insert/remove an internal sequence of the substrate. Two of these designs have been evolved experimentally in cells, leading to variants of group I intron ribozymes that splice more efficiently, recruit a cellular protein to modify the substrate’s gene expression, or elucidate evolutionary pathways of ribozymes in cells. Some of the artificial, trans-splicing ribozymes are promising as tools in therapy, and as model systems for RNA evolution in cells. This review provides an overview of the different types of trans-splicing group I intron ribozymes that have been generated, and the experimental evolution systems that have been used to improve them.

  17. Theoretical basis for unified analysis of experimental data and design of swelling-resistant alloys

    International Nuclear Information System (INIS)

    Mansur, L.K.; Lee, E.H.

    1991-01-01

    Essential aspects of the theory of radiation-induced swelling are reviewed. In particular, concepts central to the understanding of experimental data and the control of swelling by alloy design are discussed. The knowledge that a critical number of gas atoms is required in a cavity before point defect-driven swelling can begin is a most important contribution of theory. The mathematical expression that have been derived for calculating this critical quantity are given in terms of materials parameters and irradiation conditions. After swelling begins, its magnitude as a function of dose is governed strongly by the relative sink strengths for point defects of dislocations and cavities, expressed in terms of an index of the microstructure, Q. Hich swelling and low swelling microstructures can be categorized into four types based on this index. Wide ranges of experimental swelling results covering ferritic/martensite and austenitic alloys, neutron and ion irradiations and a variety of compositions and irradiation conditions are analyzed and found to be explained consistently within this framework. Based on the understanding gained, approaches to alloy design for swelling resistance are recommended. (orig.)

  18. Development of a fast, lean and agile direct pelletization process using experimental design techniques.

    Science.gov (United States)

    Politis, Stavros N; Rekkas, Dimitrios M

    2017-04-01

    A novel hot melt direct pelletization method was developed, characterized and optimized, using statistical thinking and experimental design tools. Mixtures of carnauba wax (CW) and HPMC K100M were spheronized using melted gelucire 50-13 as a binding material (BM). Experimentation was performed sequentially; a fractional factorial design was set up initially to screen the factors affecting the process, namely spray rate, quantity of BM, rotor speed, type of rotor disk, lubricant-glidant presence, additional spheronization time, powder feeding rate and quantity. From the eight factors assessed, three were further studied during process optimization (spray rate, quantity of BM and powder feeding rate), at different ratios of the solid mixture of CW and HPMC K100M. The study demonstrated that the novel hot melt process is fast, efficient, reproducible and predictable. Therefore, it can be adopted in a lean and agile manufacturing setting for the production of flexible pellet dosage forms with various release rates easily customized between immediate and modified delivery.

  19. Separation optimization of quercetin, hesperetin and chrysin in honey by micellar liquid chromatography and experimental design.

    Science.gov (United States)

    Hadjmohammadi, Mohammad Reza; Nazari, S Saman S J

    2010-10-01

    The chemometrics approach was applied for the separation optimization of flavonoid markers (quercetin, hesperetin and chrysin) in honey using micellar liquid chromatography (MLC). The investigated method combines SPE of flavonoids from honey using C(18) cartridge and their separation and quantification by micellar liquid chromatography. A two level full factorial design was carried out to evaluate the effect of four experimental factors including concentration of SDS, alkyl chain length of the alcohol used as the organic modifier (N), volume percentage of the organic modifier (V(m)) and volume percentage of acetic acid (AcOH) in mobile phase on analytes retention times. Experiments for analytes retention times modeling and optimization of separation were performed according to central composite design. Multiple linear regression method was used for the construction of the best model based on experimental retention times. Pareto optimal method was used to find suitable compatibility between resolution and analysis time of analytes in honey. The optimum mobile phase composition for separation and determination of analytes in honey were [SDS]=0.124  mol/L; 7.8% v/v ethanol and 5.0% v/v AcOH. Limits of detection and linear range of flavonoid markers were 0.0079-0.0126, 0.05-50.0  mg/L, respectively.

  20. Fast Synthesis of Gibbsite Nanoplates and Process Optimization using Box-Behnken Experimental Design

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xin [Pacific Northwest National Laboratory, Richland, Washington 99352, United States; Zhang, Xianwen [School; Graham, Trent R.; Pearce, Carolyn I. [Pacific Northwest National Laboratory, Richland, Washington 99352, United States; Mehdi, B. Layla [Pacific Northwest National Laboratory, Richland, Washington 99352, United States; N’Diaye, Alpha T. [Advanced; Kerisit, Sebastien [Pacific Northwest National Laboratory, Richland, Washington 99352, United States; Browning, Nigel D. [Pacific Northwest National Laboratory, Richland, Washington 99352, United States; Clark, Sue B. [Pacific Northwest National Laboratory, Richland, Washington 99352, United States; Rosso, Kevin M. [Pacific Northwest National Laboratory, Richland, Washington 99352, United States

    2017-10-26

    Developing the ability to synthesize compositionally and morphologically well-defined gibbsite particles at the nanoscale with high yield is an ongoing need that has not yet achieved the level of rational design. Here we report optimization of a clean inorganic synthesis route based on statistical experimental design examining the influence of Al(OH)3 gel precursor concentration, pH, and aging time at temperature. At 80 oC, the optimum synthesis conditions of gel concentration at 0.5 M, pH at 9.2, and time at 72 h maximized the reaction yield up to ~87%. The resulting gibbsite product is composed of highly uniform euhedral hexagonal nanoplates within a basal plane diameter range of 200-400 nm. The independent roles of key system variables in the growth mechanism are considered. On the basis of these optimized experimental conditions, the synthesis procedure, which is both cost-effective and environmentally friendly, has the potential for mass production scale-up of high quality gibbsite material for various fundamental research and industrial applications.

  1. Fast Bayesian experimental design: Laplace-based importance sampling for the expected information gain

    KAUST Repository

    Beck, Joakim

    2018-02-19

    In calculating expected information gain in optimal Bayesian experimental design, the computation of the inner loop in the classical double-loop Monte Carlo requires a large number of samples and suffers from underflow if the number of samples is small. These drawbacks can be avoided by using an importance sampling approach. We present a computationally efficient method for optimal Bayesian experimental design that introduces importance sampling based on the Laplace method to the inner loop. We derive the optimal values for the method parameters in which the average computational cost is minimized for a specified error tolerance. We use three numerical examples to demonstrate the computational efficiency of our method compared with the classical double-loop Monte Carlo, and a single-loop Monte Carlo method that uses the Laplace approximation of the return value of the inner loop. The first demonstration example is a scalar problem that is linear in the uncertain parameter. The second example is a nonlinear scalar problem. The third example deals with the optimal sensor placement for an electrical impedance tomography experiment to recover the fiber orientation in laminate composites.

  2. Design studies of hydraulic verification test section of windowless target of liquid lead-bismuth eutectic experimental platform

    International Nuclear Information System (INIS)

    Zhu Linglin; Bai Yunqing; Chen Zhao

    2010-01-01

    As one of the key components of the accelerator driven system (ADS), the formation and control of the free surface is one of the key issues in the design of the windowless target which needs the theoretical analysis and experimental verification. FDS team is launching the conceptual design of ADS reactor and is developing the integrative experimental platform of liquid lead-bismuth eutectic technology. The hydraulic verification facility for windowless spallation target is an important part of the platform. In this paper, the aim of the design and major parameters of the facility were described, and the major components and experimental schemes were presented. (authors)

  3. Quasi-experimental study designs series-paper 1: introduction: two historical lineages.

    Science.gov (United States)

    Bärnighausen, Till; Røttingen, John-Arne; Rockers, Peter; Shemilt, Ian; Tugwell, Peter

    2017-09-01

    The objective of this study was to contrast the historical development of experiments and quasi-experiments and provide the motivation for a journal series on quasi-experimental designs in health research. A short historical narrative, with concrete examples, and arguments based on an understanding of the practice of health research and evidence synthesis. Health research has played a key role in developing today's gold standard for causal inference-the randomized controlled multiply blinded trial. Historically, allocation approaches developed from convenience and purposive allocation to alternate and, finally, to random allocation. This development was motivated both by concerns for manipulation in allocation as well as statistical and theoretical developments demonstrating the power of randomization in creating counterfactuals for causal inference. In contrast to the sequential development of experiments, quasi-experiments originated at very different points in time, from very different scientific perspectives, and with frequent and long interruptions in their methodological development. Health researchers have only recently started to recognize the value of quasi-experiments for generating novel insights on causal relationships. While quasi-experiments are unlikely to replace experiments in generating the efficacy and safety evidence required for clinical guidelines and regulatory approval of medical technologies, quasi-experiments can play an important role in establishing the effectiveness of health care practice, programs, and policies. The papers in this series describe and discuss a range of important issues in utilizing quasi-experimental designs for primary research and quasi-experimental results for evidence synthesis. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Experimental study designs to improve the evaluation of road mitigation measures for wildlife.

    Science.gov (United States)

    Rytwinski, Trina; van der Ree, Rodney; Cunnington, Glenn M; Fahrig, Lenore; Findlay, C Scott; Houlahan, Jeff; Jaeger, Jochen A G; Soanes, Kylie; van der Grift, Edgar A

    2015-05-01

    An experimental approach to road mitigation that maximizes inferential power is essential to ensure that mitigation is both ecologically-effective and cost-effective. Here, we set out the need for and standards of using an experimental approach to road mitigation, in order to improve knowledge of the influence of mitigation measures on wildlife populations. We point out two key areas that need to be considered when conducting mitigation experiments. First, researchers need to get involved at the earliest stage of the road or mitigation project to ensure the necessary planning and funds are available for conducting a high quality experiment. Second, experimentation will generate new knowledge about the parameters that influence mitigation effectiveness, which ultimately allows better prediction for future road mitigation projects. We identify seven key questions about mitigation structures (i.e., wildlife crossing structures and fencing) that remain largely or entirely unanswered at the population-level: (1) Does a given crossing structure work? What type and size of crossing structures should we use? (2) How many crossing structures should we build? (3) Is it more effective to install a small number of large-sized crossing structures or a large number of small-sized crossing structures? (4) How much barrier fencing is needed for a given length of road? (5) Do we need funnel fencing to lead animals to crossing structures, and how long does such fencing have to be? (6) How should we manage/manipulate the environment in the area around the crossing structures and fencing? (7) Where should we place crossing structures and barrier fencing? We provide experimental approaches to answering each of them using example Before-After-Control-Impact (BACI) study designs for two stages in the road/mitigation project where researchers may become involved: (1) at the beginning of a road/mitigation project, and (2) after the mitigation has been constructed; highlighting real case

  5. Naturalistic Experimental Designs as Tools for Understanding the Role of Genes and the Environment in Prevention Research.

    Science.gov (United States)

    Leve, Leslie D; Neiderhiser, Jenae M; Harold, Gordon T; Natsuaki, Misaki N; Bohannan, Brendan J M; Cresko, William A

    2018-01-01

    Before genetic approaches were applied in experimental studies with human populations, they were used by animal and plant breeders to observe, and experimentally manipulate, the role of genes and environment on specific phenotypic or behavioral outcomes. For obvious ethical reasons, the same level of experimental control is not possible in human populations. Nonetheless, there are natural experimental designs in human populations that can serve as logical extensions of the rigorous quantitative genetic experimental designs used by animal and plant researchers. Applying concepts such as cross-fostering and common garden rearing approaches from the life science discipline, we describe human designs that can serve as naturalistic proxies for the controlled quantitative genetic experiments facilitated in life sciences research. We present the prevention relevance of three such human designs: (1) children adopted at birth by parents to whom they are not genetically related (common garden approach); (2) sibling designs where one sibling is reared from birth with unrelated adoptive parents and the other sibling is reared from birth by the biological mother of the sibling pair (cross-fostering approach); and (3) in vitro fertilization designs, including egg donation, sperm donation, embryo donation, and surrogacy (prenatal cross-fostering approach). Each of these designs allows for differentiation of the effects of the prenatal and/or postnatal rearing environment from effects of genes shared between parent and child in naturalistic ways that can inform prevention efforts. Example findings from each design type are provided and conclusions drawn about the relevance of naturalistic genetic designs to prevention science.

  6. Passing of northern pike and common carp through experimental barriers designed for use in wetland restoration

    Science.gov (United States)

    French, John R. P.; Wilcox, Douglas A.; Nichols, S. Jerrine

    1999-01-01

    Restoration plans for Metzger Marsh, a coastal wetland on the south shore of western Lake Erie, incorporated a fish-control system designed to restrict access to the wetland by large common carp (Cyprinus carpio). Ingress fish passageways in the structure contain slots into which experimental grates of varying size and shape can be placed to selectively allow entry and transfer of other large fish species while minimizing the number of common carp to be handled. We tested different sizes and shapes of grates in experimental tanks in the laboratory to determine the best design for testing in the field. We also tested northern pike (Esox lucius) because lack of access to wetland spawning habitat has greatly reduced their populations in western Lake Erie. Based on our results, vertical bar grates were chosen for installation because common carp were able to pass through circular grates smaller than body height by compressing their soft abdomens; they passed through rectangular grates on the diagonal. Vertical bar grates with 5-cm spacing that were installed across much of the control structure should limit access of common carp larger than 34 cm total length (TL) and northern pike larger than 70 cm. Vertical bar grates selected for initial field trials in the fish passageway had spacings of 5.8 and 6.6 cm, which increased access by common carp to 40 and 47 cm TL and by northern pike to 76 and 81 cm, respectively. The percentage of potential common carp biomass (fish seeking entry) that must be handled in lift baskets in the passageway increased from 0.9 to 4.8 to 15.4 with each increase in spacing between bars. Further increases in spacing would greatly increase the number of common carp that would have to be handled. The results of field testing should be useful in designing selective fish-control systems for other wetland restoration sites adjacent to large water bodies.

  7. Development of a semidefined growth medium for Pedobacter cryoconitis BG5 using statistical experimental design.

    Science.gov (United States)

    Ong, Magdalena; Ongkudon, Clarence M; Wong, Clemente Michael Vui Ling

    2016-10-02

    Pedobacter cryoconitis BG5 are psychrophiles isolated from the cold environment and capable of proliferating and growing well at low temperature regime. Their cellular products have found a broad spectrum of applications, including in food, medicine, and bioremediation. Therefore, it is imperative to develop a high-cell density cultivation strategy coupled with optimized growth medium for P. cryoconitis BG5. To date, there has been no published report on the design and optimization of growth medium for P. cryoconitis, hence the objective of this research project. A preliminary screening of four commercially available media, namely tryptic soy broth, R2A, Luria Bertani broth, and nutrient broth, was conducted to formulate the basal medium. Based on the preliminary screening, tryptone, glucose, NaCl, and K2HPO4 along with three additional nutrients (yeast extract, MgSO4, and NH4Cl) were identified to form the basal medium which was further analyzed by Plackett-Burman experimental design. Central composite experimental design using response surface methodology was adopted to optimize tryptone, yeast extract, and NH4Cl concentrations in the formulated growth medium. Statistical data analysis showed a high regression factor of 0.84 with a predicted optimum optical (600 nm) cell density of 7.5 using 23.7 g/L of tryptone, 8.8 g/L of yeast extract, and 0.7 g/L of NH4Cl. The optimized medium for P. cryoconitis BG5 was tested, and the observed optical density was 7.8. The cost-effectiveness of the optimized medium was determined as 6.25 unit prices per gram of cell produced in a 250-ml Erlenmeyer flask.

  8. Design of high-pressure direct contact heater for promising power supply units: Experimental substantiation

    Science.gov (United States)

    Somova, E. V.; Shvarts, A. L.; Turkin, A. V.

    2016-11-01

    The results of experimental studies of superheated steam condensation on feed water jets in a highpressure, direct-contact heat exchanger are presented. Direct contact feed water heater (DCFWH) can be used in a dual-flow diagram of a steam-power unit with ultrasupercritical steam parameters (35 MPa, 700/720°C). The direct contact feed water heater is included in the flow diagram of the II circuit in a promising power unit; it provides feed water heating to 340°C in all maintenance and emergency operation modes of the unit. The reliability of the high-pressure direct contact heater operation in this flow diagram is of major importance in relation to the danger of lead solidification in the tube space of the steam generator. Technical requirements to the design of the high-pressure direct contact heater for increasing the heat exchange efficiency are formulated based on the results of earlier studies with steam-water mixture as the heating medium. The results of studies of superheated steam condensation on jets presented in this study testify that feed water is additionally heated to the required temperature at the output of the installation. The influence of initial feed water parameters (outflow velocity and temperature) on the jet heating length is elucidated. The numerical approximation of the experimental data for determination of the jet heating length in the nominal and partial power unit loads is obtained. The results of the calculations are used to simplify the design of the water-supplying element for the direct contact feed water heater. The proposed design of direct contact feed water heater is characterized by simplicity and low metal intensity, which provides the installation reliability at the considered pressure level due to the minimum number of structural elements.

  9. Kriging for Simulation Metamodeling: Experimental Design, Reduced Rank Kriging, and Omni-Rank Kriging

    Science.gov (United States)

    Hosking, Michael Robert

    This dissertation improves an analyst's use of simulation by offering improvements in the utilization of kriging metamodels. There are three main contributions. First an analysis is performed of what comprises good experimental designs for practical (non-toy) problems when using a kriging metamodel. Second is an explanation and demonstration of how reduced rank decompositions can improve the performance of kriging, now referred to as reduced rank kriging. Third is the development of an extension of reduced rank kriging which solves an open question regarding the usage of reduced rank kriging in practice. This extension is called omni-rank kriging. Finally these results are demonstrated on two case studies. The first contribution focuses on experimental design. Sequential designs are generally known to be more efficient than "one shot" designs. However, sequential designs require some sort of pilot design from which the sequential stage can be based. We seek to find good initial designs for these pilot studies, as well as designs which will be effective if there is no following sequential stage. We test a wide variety of designs over a small set of test-bed problems. Our findings indicate that analysts should take advantage of any prior information they have about their problem's shape and/or their goals in metamodeling. In the event of a total lack of information we find that Latin hypercube designs are robust default choices. Our work is most distinguished by its attention to the higher levels of dimensionality. The second contribution introduces and explains an alternative method for kriging when there is noise in the data, which we call reduced rank kriging. Reduced rank kriging is based on using a reduced rank decomposition which artificially smoothes the kriging weights similar to a nugget effect. Our primary focus will be showing how the reduced rank decomposition propagates through kriging empirically. In addition, we show further evidence for our

  10. De novo peptide design and experimental validation of histone methyltransferase inhibitors.

    Directory of Open Access Journals (Sweden)

    James Smadbeck

    Full Text Available Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA-protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2 maintains gene repression over successive cell generations. Overexpression of EZH2 can silence important tumor suppressor genes leading to increased invasiveness of many types of cancers. This makes the inhibition of EZH2 an important target in the development of cancer therapeutics. We employed a three-stage computational de novo peptide design method to design inhibitory peptides of EZH2. The method consists of a sequence selection stage and two validation stages for fold specificity and approximate binding affinity. The sequence selection stage consists of an integer linear optimization model that was solved to produce a rank-ordered list of amino acid sequences with increased stability in the bound peptide-EZH2 structure. These sequences were validated through the calculation of the fold specificity and approximate binding affinity of the designed peptides. Here we report the discovery of novel EZH2 inhibitory peptides using the de novo peptide design method. The computationally discovered peptides were experimentally validated in vitro using dose titrations and mechanism of action enzymatic assays. The peptide with the highest in vitro response, SQ037, was validated in nucleo using quantitative mass spectrometry-based proteomics. This peptide had an IC50 of 13.5 [Formula: see text]M, demonstrated greater potency as an inhibitor when compared to the native and K27A mutant control peptides, and demonstrated competitive inhibition versus the peptide substrate. Additionally, this peptide demonstrated high specificity to the EZH2 target in comparison to other histone methyltransferases. The validated peptides are the first computationally designed peptides that directly

  11. De novo peptide design and experimental validation of histone methyltransferase inhibitors.

    Directory of Open Access Journals (Sweden)

    James Smadbeck

    Full Text Available Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA–protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2 maintains gene repression over successive cell generations. Overexpression of EZH2 can silence important tumor suppressor genes leading to increased invasiveness of many types of cancers. This makes the inhibition of EZH2 an important target in the development of cancer therapeutics. We employed a three-stage computational de novo peptide design method to design inhibitory peptides of EZH2. The method consists of a sequence selection stage and two validation stages for fold specificity and approximate binding affinity. The sequence selection stage consists of an integer linear optimization model that was solved to produce a rank-ordered list of amino acid sequences with increased stability in the bound peptide-EZH2 structure. These sequences were validated through the calculation of the fold specificity and approximate binding affinity of the designed peptides. Here we report the discovery of novel EZH2 inhibitory peptides using the de novo peptide design method. The computationally discovered peptides were experimentally validated in vitro using dose titrations and mechanism of action enzymatic assays. The peptide with the highest in vitro response, SQ037, was validated in nucleo using quantitative mass spectrometry-based proteomics. This peptide had an IC50 of 13.5 mM, demonstrated greater potency as an inhibitor when compared to the native and K27A mutant control peptides, and demonstrated competitive inhibition versus the peptide substrate. Additionally, this peptide demonstrated high specificity to the EZH2 target in comparison to other histone methyltransferases. The validated peptides are the first computationally designed peptides that directly inhibit EZH2

  12. Experimental evaluation and design of unfilled and concrete-filled FRP composite piles, task 1 - mechanical properties of FRP piles.

    Science.gov (United States)

    2014-10-01

    The overall goal of this project is the experimental evaluation and design of unfilled and concrete-filled FRP : composite piles for load-bearing in bridges. This report covers Task 1, Mechanical Properties of FRP Piles. : Mechanical and geotechnic...

  13. Seismic design assessment by experimental methods. Notes from the workshop. Working material

    International Nuclear Information System (INIS)

    2001-01-01

    The workshop intended to provide training on the application of experimental techniques (mainly laboratory testing) as support to the seismic design of structures, equipment and components for nuclear power plants. The focus was on the activities planned by Nuclear Power Institute of China (NPIC) in the near future, and most of the lectures provided by the attendees, dealing with these national activities, were the basis for the discussion with the IAEA experts. Special modules were identified for the workshop, dealing with: Numerical models: detailing and comparison techniques; On site testing of structures and equipment; Special problems: Leak before Break (LBB), thermal effects, combination of seismic with other loads; General seismic behavior and design criteria for fuel assembly and core structures; Seismic qualification methodologies for reactor core, mechanical components, I and C and piping; Balancing analysis and test in seismic qualification; Design of mock-up: selection of seismic input, detailing, scaling and similitudes, selection of sensors and their location; Test planning and conduct, basic documents and specifications; Quality assurance and technical procedures in laboratory testing; Data processing techniques and interface with the numerical models. The material used for presentations by the lecturers and by the national attendees is collected in this volume together with some background literature provided by the experts with up to date references and procedures. A special chapter is added to these proceedings with the content of the discussion, for future reference and as a complement to the lectures content, more oriented to the specific, immediate needs of the attendees

  14. Design and Experimental Validation for Direct-Drive Fault-Tolerant Permanent-Magnet Vernier Machines

    Directory of Open Access Journals (Sweden)

    Guohai Liu

    2014-01-01

    Full Text Available A fault-tolerant permanent-magnet vernier (FT-PMV machine is designed for direct-drive applications, incorporating the merits of high torque density and high reliability. Based on the so-called magnetic gearing effect, PMV machines have the ability of high torque density by introducing the flux-modulation poles (FMPs. This paper investigates the fault-tolerant characteristic of PMV machines and provides a design method, which is able to not only meet the fault-tolerant requirements but also keep the ability of high torque density. The operation principle of the proposed machine has been analyzed. The design process and optimization are presented specifically, such as the combination of slots and poles, the winding distribution, and the dimensions of PMs and teeth. By using the time-stepping finite element method (TS-FEM, the machine performances are evaluated. Finally, the FT-PMV machine is manufactured, and the experimental results are presented to validate the theoretical analysis.

  15. Experimental Analyses for The Mechanical Behavior of Pressed All-Ceramic Molar Crowns with Anatomical Design

    Directory of Open Access Journals (Sweden)

    Porojan Liliana

    2017-01-01

    Full Text Available Ceramic restorations show considerable variation in strength and structural reliability regarding to the type of material, and design characteristics. The fracture of ceramics occurs with little or no plastic deformation, with cracks propagated in an unstable manner under applied tensile stresses. The aim of the study was to assess experimental analyses of pressed monolithic ceramic crowns with anatomical design used in the posterior areas in order to understand their mechanical behavior before following their clinical use. Experiments were conducted on a complete molar crown preparation. Experiments show different modes of fracture for the tested samples. Digital images from the fractured pieces of the crowns were used to verify the fragments in all cases final fracture occurred by splitting into two and often more parts. The graphically representation of the displacement depending on the load highlights a series of peaks that can be correlated with cracks occurred in crowns. The development of well-designed mechanical experiments could be useful to help to predict clinical survival of these new all-ceramic restorative techniques and materials. Because failure is often accompanied by complete cracking of the crowns, preliminary research should represents a compulsory goal.

  16. Rugby-like hohlraum experimental designs for demonstrating x-ray drive enhancement

    International Nuclear Information System (INIS)

    Amendt, Peter; Cerjan, C.; Hinkel, D. E.; Milovich, J. L.; Park, H.-S.; Robey, H. F.

    2008-01-01

    A suite of experimental designs for the Omega laser facility [Boehly et al., Opt. Commun. 133, 495 (1997)] using rugby and cylindrical hohlraums is proposed to confirm the energetics benefits of rugby-shaped hohlraums over cylinders under optimal implosion symmetry conditions. Postprocessed Dante x-ray drive measurements predict a 12-17 eV (23%-36%) peak hohlraum temperature (x-ray flux) enhancement for a 1 ns flattop laser drive history. Simulated core self-emission x-ray histories also show earlier implosion times by 200-400 ps, depending on the hohlraum case-to-capsule ratio and laser-entrance-hole size. Capsules filled with 10 or 50 atm of deuterium (DD) are predicted to give in excess of 10 10 neutrons in two-dimensional hohlraum simulations in the absence of mix, enabling DD burn history measurements for the first time in indirect-drive on Omega. Capsule designs with 50 atm of D 3 He are also proposed to make use of proton slowing for independently verifying the drive benefits of rugby hohlraums. Scale-5/4 hohlraum designs are also introduced to provide further margin to potential laser-plasma-induced backscatter and hot-electron production

  17. Quasi-experimental study designs series-paper 6: risk of bias assessment.

    Science.gov (United States)

    Waddington, Hugh; Aloe, Ariel M; Becker, Betsy Jane; Djimeu, Eric W; Hombrados, Jorge Garcia; Tugwell, Peter; Wells, George; Reeves, Barney

    2017-09-01

    Rigorous and transparent bias assessment is a core component of high-quality systematic reviews. We assess modifications to existing risk of bias approaches to incorporate rigorous quasi-experimental approaches with selection on unobservables. These are nonrandomized studies using design-based approaches to control for unobservable sources of confounding such as difference studies, instrumental variables, interrupted time series, natural experiments, and regression-discontinuity designs. We review existing risk of bias tools. Drawing on these tools, we present domains of bias and suggest directions for evaluation questions. The review suggests that existing risk of bias tools provide, to different degrees, incomplete transparent criteria to assess the validity of these designs. The paper then presents an approach to evaluating the internal validity of quasi-experiments with selection on unobservables. We conclude that tools for nonrandomized studies of interventions need to be further developed to incorporate evaluation questions for quasi-experiments with selection on unobservables. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Randomized block experimental designs can increase the power and reproducibility of laboratory animal experiments.

    Science.gov (United States)

    Festing, Michael F W

    2014-01-01

    Randomized block experimental designs have been widely used in agricultural and industrial research for many decades. Usually they are more powerful, have higher external validity, are less subject to bias, and produce more reproducible results than the completely randomized designs typically used in research involving laboratory animals. Reproducibility can be further increased by using time as a blocking factor. These benefits can be achieved at no extra cost. A small experiment investigating the effect of an antioxidant on the activity of a liver enzyme in four inbred mouse strains, which had two replications (blocks) separated by a period of two months, illustrates this approach. The widespread failure to use these designs more widely in research involving laboratory animals has probably led to a substantial waste of animals, money, and scientific resources and slowed down the development of new treatments for human and animal diseases. © The Author 2014. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  19. Rugby-like hohlraum experimental designs for demonstrating x-ray drive enhancement

    Science.gov (United States)

    Amendt, Peter; Cerjan, C.; Hinkel, D. E.; Milovich, J. L.; Park, H.-S.; Robey, H. F.

    2008-01-01

    A suite of experimental designs for the Omega laser facility [Boehly et al., Opt. Commun. 133, 495 (1997)] using rugby and cylindrical hohlraums is proposed to confirm the energetics benefits of rugby-shaped hohlraums over cylinders under optimal implosion symmetry conditions. Postprocessed Dante x-ray drive measurements predict a 12-17eV (23%-36%) peak hohlraum temperature (x-ray flux) enhancement for a 1ns flattop laser drive history. Simulated core self-emission x-ray histories also show earlier implosion times by 200-400ps, depending on the hohlraum case-to-capsule ratio and laser-entrance-hole size. Capsules filled with 10 or 50atm of deuterium (DD) are predicted to give in excess of 1010 neutrons in two-dimensional hohlraum simulations in the absence of mix, enabling DD burn history measurements for the first time in indirect-drive on Omega. Capsule designs with 50atm of DHe3 are also proposed to make use of proton slowing for independently verifying the drive benefits of rugby hohlraums. Scale-5/4 hohlraum designs are also introduced to provide further margin to potential laser-plasma-induced backscatter and hot-electron production.

  20. Design and Experimental Investigation of Pneumatic Movement Mechanism Supported by Mechanic Cam and Crank Shaft

    Directory of Open Access Journals (Sweden)

    Salih KORUCU

    2015-02-01

    Full Text Available The pressurized air is applied to many sectors required purity and velocity. One of these sectors is to use of air as impulsive force in the moving mechanisms. In this study, the movement mechanism prototype worked with compressed air was designed and produced forlight vehicle engine as motorbike and ATV (All-Terrain Vehicle. In developed mechanisms, pneumatic artificial muscles were used for a given movement of crankshaft. A cam system was also designed for synchronization pneumatic muscles. In this way, these muscles transmit the synchronous movement to crankshaft. At the end of the study, the developed mechanism was mounted on an ATV vehicle(110 cc/ Cubic Centimeter, engine displacement capacityand its performance was tested using the four different weights (50, 75, 100 and 150 kg, three different pressures (4, 5 and 6 bar and two different hoses (Ø 6 and Ø 8 mm. By considering experimental results and design criteria, power of the movement mechanism was obtained as 886 Watt. With this study, minimization of energy consumption for movement of passenger cars, and using clean and cheap energy as ATV which can be alternative for single or two passenger vehicles.

  1. Design and experimental validation of a simple controller for a multi-segment magnetic crawler robot

    Science.gov (United States)

    Kelley, Leah; Ostovari, Saam; Burmeister, Aaron B.; Talke, Kurt A.; Pezeshkian, Narek; Rahimi, Amin; Hart, Abraham B.; Nguyen, Hoa G.

    2015-05-01

    A novel, multi-segmented magnetic crawler robot has been designed for ship hull inspection. In its simplest version, passive linkages that provide two degrees of relative motion connect front and rear driving modules, so the robot can twist and turn. This permits its navigation over surface discontinuities while maintaining its adhesion to the hull. During operation, the magnetic crawler receives forward and turning velocity commands from either a tele-operator or high-level, autonomous control computer. A low-level, embedded microcomputer handles the commands to the driving motors. This paper presents the development of a simple, low-level, leader-follower controller that permits the rear module to follow the front module. The kinematics and dynamics of the two-module magnetic crawler robot are described. The robot's geometry, kinematic constraints and the user-commanded velocities are used to calculate the desired instantaneous center of rotation and the corresponding central-linkage angle necessary for the back module to follow the front module when turning. The commands to the rear driving motors are determined by applying PID control on the error between the desired and measured linkage angle position. The controller is designed and tested using Matlab Simulink. It is then implemented and tested on an early two-module magnetic crawler prototype robot. Results of the simulations and experimental validation of the controller design are presented.

  2. Polyamide Microparticles Containing Vitamin C by Interfacial Polymerization: An Approach by Design of Experimentation

    Directory of Open Access Journals (Sweden)

    Lionel Ripoll

    2016-11-01

    Full Text Available Vitamin C is widely use in cosmetics and pharmaceutics products for its active properties. However ascorbic acid shows unfavourable chemical instability such as oxidation leading to formulation problems. Therefore, carriers, such as micro- and nanoparticles, have been widely investigated as delivery systems for vitamin C to improve its beneficial effects in skin treatment. However, none of the previous studies have been able to produce microparticles with a high encapsulation entrapment of vitamin C. The aim of the present study is to use an experimental design to optimize the synthesis of polyamide microparticles for the delivery of ascorbic acid. The effect of four formulation parameters on microparticles properties (size and morphology, encapsulation efficiency and yield, release kinetics were investigated using a surface response design. Finally, we were able to obtain stable microparticles containing more than 65% of vitamin C. This result confirms the effectiveness of using design of experiments for the optimisation of microparticle formulation and supports the proposal of using them as candidate for the delivery of vitamin C in skin treatment.

  3. Experimental analysis of the performance of an air-water heat pump designed for R22 working with propane

    International Nuclear Information System (INIS)

    Mura, P.G.; Carlini, U.; Innamorati, R.

    2001-01-01

    After describing the technical characteristics of a heat pump designed for R22, the changes necessary to fit the use of propane and the experimental set-up, in this article the research program on propane as refrigerant is presented, together with the experimental results of the chiller performance with R22 and R290 in cooling mode [it

  4. Pre-X Experimental Re-Entry Lifting Body: Design of Flight Test Experiments for Critical Aerothermal Phenomena

    Science.gov (United States)

    2007-06-01

    PRE-X EXPERIMENTAL RE-ENTRY LIFTING BODY: DESIGN OF FLIGHT TEST EXPERIMENTS FOR CRITICAL AEROTHERMAL PHENOMENA Paolo Baiocco * * CNES...ACRONYMS ACS Attitude Control System AEDB Aero Dynamic Data Base AoA Angle of Attack ARD Atmospheric Re-entry Demonstrator ATD Aero Termo ...1 Baiocco, P. (2007) Pre-X Experimental Re-entry Lifting Body: Design of Flight Test Experiments for Critical Aerothermal Phenomena. In Flight

  5. Preliminary design of ECCO: Experimental control system which is cloud oriented

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Wei, E-mail: zhengwei@hust.edu.cn [State Key Laboratory of Advanced Electromagnetic Engineering and Technology in Huazhong University of Science and Technology, Wuhan 430074 (China); School of Electrical and Electronic Engineering in Huazhong University of Science and Technology, Wuhan 430074 (China); Hu, Feiran; Zhang, Ming; Zhang, Jing; Wan, Kuanhong; Liu, Qiang; Pan, Yuan; Zhuang, Ge [State Key Laboratory of Advanced Electromagnetic Engineering and Technology in Huazhong University of Science and Technology, Wuhan 430074 (China); School of Electrical and Electronic Engineering in Huazhong University of Science and Technology, Wuhan 430074 (China)

    2016-11-15

    Highlights: • ECCO is a self-organized and de-centralized control system software. • ECCO integrates ECCO-SDD and ECCO-REST.. • ECCO network protocol is based on HTTP protocol and RESTful design practice, implements Hypermedia, automatic discovery, and event. • ECCO is flexible, plug-and-play, and provides a series of unified toolkits. - Abstract: As the development of the Tokamak, the scale of the facility is getting bigger and bigger. It is a great challenge to design, manage and operate a control system of such big scale. So we developed a new control system software: Experimental Control System which is Cloud Oriented (ECCO). ECCO consists two parts, ECCO-SDD and ECCO-REST. ECCO-SDD is used to design, manage and describe the whole control system, configure every subsystem statically. There is a SDD editor which is a human machine interface for control system designer to design by simply drag and drop, and it can be easily extended using plug-in. The ECCO-SDD translator is used to generate different outputs. All the system design and configuration is stored in the MongoDB database using an object relational mapping dedicated designed for ECCO-SDD. ECCO-REST mainly defines a control network protocol based on HTTP RESTful service, it also implements automatic discovery using Zero-configuration (Zeroconf) networking standard. Since this protocol is based on industrial standard and transparent protocol, it is open enough and it can be easily implemented by others. ECCO-REST application is the core of ECCO-REST, it is a cross platform control software running on distributed control units just like the EPICS IOC. It can be extended by user created models. It is configured by human readable JSON file which can be generated by ECCO-SDD translator. ECCO is a self-organized and de-centralized control system software. Based on the same protocol, every part of the system can discover each other, thus the controllers which ECCO-REST application running on can

  6. Preliminary design of ECCO: Experimental control system which is cloud oriented

    International Nuclear Information System (INIS)

    Zheng, Wei; Hu, Feiran; Zhang, Ming; Zhang, Jing; Wan, Kuanhong; Liu, Qiang; Pan, Yuan; Zhuang, Ge

    2016-01-01

    Highlights: • ECCO is a self-organized and de-centralized control system software. • ECCO integrates ECCO-SDD and ECCO-REST.. • ECCO network protocol is based on HTTP protocol and RESTful design practice, implements Hypermedia, automatic discovery, and event. • ECCO is flexible, plug-and-play, and provides a series of unified toolkits. - Abstract: As the development of the Tokamak, the scale of the facility is getting bigger and bigger. It is a great challenge to design, manage and operate a control system of such big scale. So we developed a new control system software: Experimental Control System which is Cloud Oriented (ECCO). ECCO consists two parts, ECCO-SDD and ECCO-REST. ECCO-SDD is used to design, manage and describe the whole control system, configure every subsystem statically. There is a SDD editor which is a human machine interface for control system designer to design by simply drag and drop, and it can be easily extended using plug-in. The ECCO-SDD translator is used to generate different outputs. All the system design and configuration is stored in the MongoDB database using an object relational mapping dedicated designed for ECCO-SDD. ECCO-REST mainly defines a control network protocol based on HTTP RESTful service, it also implements automatic discovery using Zero-configuration (Zeroconf) networking standard. Since this protocol is based on industrial standard and transparent protocol, it is open enough and it can be easily implemented by others. ECCO-REST application is the core of ECCO-REST, it is a cross platform control software running on distributed control units just like the EPICS IOC. It can be extended by user created models. It is configured by human readable JSON file which can be generated by ECCO-SDD translator. ECCO is a self-organized and de-centralized control system software. Based on the same protocol, every part of the system can discover each other, thus the controllers which ECCO-REST application running on can

  7. Stress Regression Analysis of Asphalt Concrete Deck Pavement Based on Orthogonal Experimental Design and Interlayer Contact

    Science.gov (United States)

    Wang, Xuntao; Feng, Jianhu; Wang, Hu; Hong, Shidi; Zheng, Supei

    2018-03-01

    A three-dimensional finite element box girder bridge and its asphalt concrete deck pavement were established by ANSYS software, and the interlayer bonding condition of asphalt concrete deck pavement was assumed to be contact bonding condition. Orthogonal experimental design is used to arrange the testing plans of material parameters, and an evaluation of the effect of different material parameters in the mechanical response of asphalt concrete surface layer was conducted by multiple linear regression model and using the results from the finite element analysis. Results indicated that stress regression equations can well predict the stress of the asphalt concrete surface layer, and elastic modulus of waterproof layer has a significant influence on stress values of asphalt concrete surface layer.

  8. Optimal experimental designs for accelerated failure time with Type I and random censoring.

    Science.gov (United States)

    Rivas-López, María J; López-Fidalgo, Jesús; Campo, Rodrigo Del

    2014-09-01

    Proportional Hazards models have been widely used to analyze survival data. In many cases survival data do not verify the assumption of proportional hazards. An alternative to the PH models with more relaxed conditions are Accelerated Failure Time models. These models are fairly commonly used in the field of manufacturing, but they are more and more frequent for modeling clinical trial data. They focus on the direct effect of the explanatory variables on the survival function allowing an easier interpretation of the effect of the corresponding covariates on the survival time. Optimal experimental designs are computed in this framework for Type I and random arrival. The results are applied to clinical models used to prevent tuberculosis in Ugandan adults infected with HIV. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Six playback experimental designs fail to demonstrate acoustic preferences in common waxbills (Estrildidae: Estrilda astrild).

    Science.gov (United States)

    Funghi, Caterina; Cardoso, Gonçalo C

    2015-06-01

    Playback experiments in controlled laboratory settings have been instrumental in studies of animal communication and signal evolution. Nonetheless, applying common methods to wild or non-model species can be challenging. We tested male and female common waxbills (Estrilda astrild) for behavioural preferences of conspecific vs. heterospecific songs, and of conspecific song vs. calls. Although common waxbills are related to model species used in this type of experiments, we could not demonstrate the predicted preference for conspecific over heterospecific song, or differential behavioural responses for conspecific song vs. calls. We confirm these results with experimental designs that either monitor movements, vocal responses, or active eliciting of playbacks, and that test birds in isolation or not, with or without visual stimuli accompanying playbacks. We discuss difficulties that may commonly apply to playback experiments with wild and social animals, and stress the importance of using simple discrimination tasks to validate common methods in novel species. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Xylanase Production by Aspergillus niger LPB 326 in Solid-State Fermentation Using Statistical Experimental Designs

    Directory of Open Access Journals (Sweden)

    Giselle Maria Maciel

    2008-01-01

    Full Text Available Xylanase was produced by Aspergillus niger LPB 326 cultivated on lignocellulosic substrate composed by sugarcane bagasse and soybean meal in solid-state fermentation. The effects of various variables were observed and optimized by applying statistical experimental designs. The best xylanase activity was obtained in a medium containing 10 g of sugarcane bagasse and soybean meal in the ratio of 65 and 35 %, respectively, moistened to 85 % of initial water content with a nutrient salt solution composed of (in g/L: CuSO4 0.4, KH2PO4 1.5 and CoSO4 0.0012, and incubated for 4 days at 30 °C. Under these optimized conditions, a xylanase activity of 3099 IU/g of dry matter was obtained.

  11. Design and experimental research of hydraulic control rod drive system for 5 MW THR

    International Nuclear Information System (INIS)

    Wu Yuanqiang; Hu Yuedong; Cheng Yunsheng; Yang Nianzu; Liu Chengying; Zhang Fulu

    1990-01-01

    Hydraulic control rod drive system (HCRDS) is a new device of control rod drive which is different from usual electric-magnetic mechanic drive used for water power nuclear reactor. The coolant(water) is used as actuating medium, pumped by canned-pump, then injected into hydraulic step cylinders which are set in the reactor vessel. The outer tube of the step cylinder will be moving step by step by controling of the flow, driving the neutron absorber. 5MW THR is the first reactor in the world in which the hydraulic step drive system was used. Using of the drive system is for getting better safety, reliability and lower cost. In this paper, the design and experimental research of the system are introduced

  12. Visual analysis in single case experimental design studies: brief review and guidelines.

    Science.gov (United States)

    Lane, Justin D; Gast, David L

    2014-01-01

    Visual analysis of graphic displays of data is a cornerstone of studies using a single case experimental design (SCED). Data are graphed for each participant during a study with trend, level, and stability of data assessed within and between conditions. Reliable interpretations of effects of an intervention are dependent on researchers' understanding and use of systematic procedures. The purpose of this paper is to provide readers with a rationale for visual analysis of data when using a SCED, a step-by-step guide for conducting a visual analysis of graphed data, as well as to highlight considerations for persons interested in using visual analysis to evaluate an intervention, especially the importance of collecting reliability data for dependent measures and fidelity of implementation of study procedures.

  13. Experimental design and process analysis for acidic leaching of metal-rich glass wastes.

    Science.gov (United States)

    Tuncuk, A; Ciftci, H; Akcil, A; Ognyanova, A; Vegliò, F

    2010-05-01

    The removal of iron, titanium and aluminium from colourless and green waste glasses has been studied under various experimental conditions in order to optimize the process parameters and to decrease the metal content in the waste glass by acidic leaching. Statistical design of experiments and ANOVA (analysis of variance) were performed in order to determine the main effects and interactions between the investigated factors (sample ratio, acid concentration, temperature and leaching time). A full factorial experiment was performed by sulphuric acid leaching of glass for metal removal. After treating, the iron content was 530 ppm, corresponding to 1880 ppm initial concentration of Fe(2)O(3) in the original colourless sample. This result is achieved using 1M H(2)SO( 4) and 30% sample ratio at 90(o)C leaching temperature for 2 hours. The iron content in the green waste glass sample was reduced from 3350 ppm initial concentration to 2470 ppm after treating.

  14. Signal charge sharing in multilinear drift detectors: Design and experimental characterization

    Energy Technology Data Exchange (ETDEWEB)

    Castoldi, A. [Univ. degli Studi di Milano (Italy). Dipt. di Fisica; Rehak, P. [Brookhaven National Lab., Upton, NY (United States); Holl, P. [3MPI Halbleiterlabor, Muenchen (Germany)

    1997-04-01

    Multilinear silicon drift detectors (MLSDD`s) are radiation detectors which combine excellent energy and position resolution with high count-rate capabilities. This is achieved by controlling the diffusion of the signal charges and limiting their lateral spread during the drift. This paper will present a study of the signal electrons` transport in MLSDD`s in comparison with the experimental measurements. Three-dimensional simulations were carried out, taking into account diffusion effects and mutual electrostatic interaction between the signal electrons. A representative sample of these simulations will be presented. Signal sharing in a multilinear drift detector and in a classical multi-anode drift detector are characterized and discussed. The results are useful to tailor the design of MLSDD`s for the detection of different kinds of radiation (e.g., optical photon, X-ray, ionizing particle) and to optimize signal charge sharing and detector performance according to a particular application purpose.

  15. Experimental Investigation of Friction Effect on Liner Model Rolling Bearings for Large Diameter Thrust Bearing Design

    Directory of Open Access Journals (Sweden)

    S. Babu

    2012-12-01

    Full Text Available Studying friction coefficient has significant importance, especially when dealing with high load and temperature applications that have frequent starting and stopping points. Towards that, two sets of angular contact Linear Model Mockup Bearings (LMMB were designed and fabricated. This linear model assembly was made up of high precision, grounded raceways (AISI 4140 and commercially purchased balls (AISI 52100. The experimental studies were carried out by placing different number of balls between the raceways under different loads at dry lubricating condition. The static friction coefficients were measured using two different experiments: viz gravitation-based experiment and direct linear force measurement experiment. And Digital Image Correlation (DIC technique was used to find the stiffness of LMMB set.

  16. Review of the International Thermonuclear Experimental Reactor (ITER) detailed design report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-18

    Dr. Martha Krebs, Director, Office of Energy Research at the US Department of Energy (DOE), wrote to the Fusion Energy Sciences Advisory Committee (FESAC), in letters dated September 23 and November 6, 1996, requesting that FESAC review the International Thermonuclear Experimental Reactor (ITER) Detailed Design Report (DDR) and provide its view of the adequacy of the DDR as part of the basis for the United States decision to enter negotiations with the other interested Parties regarding the terms and conditions for an agreement for the construction, operations, exploitation and decommissioning of ITER. The letter from Dr. Krebs, referred to as the Charge Letter, provided context for the review and a set of questions of specific interest.

  17. Pressurized water extraction of isoflavones by experimental design from soybean flour and Soybean Protein Isolate.

    Science.gov (United States)

    Moras, Benjamin; Rey, Stéphane; Vilarem, Gérard; Pontalier, Pierre-Yves

    2017-01-01

    A Doehlert experimental design was conducted and surface response methodology was used to determine the effect of temperature, contact time and solid liquid ratio on isoflavone extraction from soybean flour or Soybean Protein Isolate in pressurized water system. The optimal conditions conducted gave an extraction yield of 85% from soybean flour. For Soybean Protein Isolate compared to soybean flour, the isoflavone extraction yield is 61%. This difference could be explained by higher aglycon content, while aglycon appears to be the least extracted isoflavone by pressurized water. The solid liquid ratio in the ASE cell was the overriding factor in obtaining high yields with both soybean products, while temperature has less influence. A high temperature causes conversion of the malonyls-glucosides and glucosides isoflavone derivatives into glucosides or aglycons forms. pressurized water extraction showed a high solubilization of protein material up to 95% of inserted Soybean Protein Isolate. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Using experimental design modules for process characterization in manufacturing/materials processes laboratories

    Science.gov (United States)

    Ankenman, Bruce; Ermer, Donald; Clum, James A.

    1994-01-01

    Modules dealing with statistical experimental design (SED), process modeling and improvement, and response surface methods have been developed and tested in two laboratory courses. One course was a manufacturing processes course in Mechanical Engineering and the other course was a materials processing course in Materials Science and Engineering. Each module is used as an 'experiment' in the course with the intent that subsequent course experiments will use SED methods for analysis and interpretation of data. Evaluation of the modules' effectiveness has been done by both survey questionnaires and inclusion of the module methodology in course examination questions. Results of the evaluation have been very positive. Those evaluation results and details of the modules' content and implementation are presented. The modules represent an important component for updating laboratory instruction and to provide training in quality for improved engineering practice.

  19. Conceptual design of experimental LFR fuel element for testing in TRIGA reactor, ACPR zone

    International Nuclear Information System (INIS)

    Nastase, D.; Olteanu, G.; Ioan, M.; Pauna, E.

    2013-01-01

    In the pulsed area of the TRIGA reactor (ACPR zone), the irradiation tests called ''rapid insertions of reactivity on different types of nuclear fuel elements'' are usually realized. During these tests, in the fuel element high powers for a relatively short period of time (about few milliseconds) are generated. The generated heat in fuel pellets raise their central temperature to values over 100 deg C. The conceptual design of an experimental fuel element proposed to be developed and presented in this paper must fulfill a couple of requirements, as follows: to ensure full compatibility with irradiation device sample holder (compatibility is achieved through reduced length of the fuel stack pellets - this way assures a flow flattening on the entire length of the fuel element); to be compatible with the project of irradiated fuel bundle in Lead cooled Fast Reactors (LFR). (authors)

  20. A note on the analysis of germination data from complex experimental designs

    DEFF Research Database (Denmark)

    Jensen, Signe Marie; Andreasen, Christian; Streibig, Jens Carl

    2017-01-01

    In recent years germination experiments have become more and more complex. Typically, they are replicated in time as independent runs and at each time point they involve hierarchical, often factorial experimental designs, which are now commonly analysed by means of linear mixed models. However......, in order to characterize germination in response to time elapsed, specific event-time models are needed and mixed model extensions of these models are not readily available, neither in theory nor in practice. As a practical workaround we propose a two-step approach that combines and weighs together results...... from event-time models fitted separately to data from each germination test by means of meta-analytic random effects models. We show that this approach provides a more appropriate appreciation of the sources of variation in hierarchically structured germination experiments as both between- and within...

  1. A wideband fractal-inspired piezoelectric energy converter: design, simulation and experimental characterization

    International Nuclear Information System (INIS)

    Castagnetti, Davide

    2013-01-01

    In order to develop self-powered wireless sensor nodes, many energy harvesting devices that are able to convert available ambient energy into electrical energy have been proposed in the literature. A promising technique, in terms of simplicity and high conversion efficiency, is the harvesting of ambient kinetic energy through piezoelectric materials. The aim of this work is to design and investigate the modal response and power output of a fractal-inspired, multi-frequency, piezoelectric energy converter. The converter is a square, thin sheet structure, characterized by a fractal geometry obtained through a pattern of cuts in the plate. There are two steps involved. First, a computational analysis of the converter is performed. Second, a physical prototype of the converter is built and its eigenfrequencies and power generation under different resistive loads are experimentally examined in the range from 0 to 120 Hz. The converter exhibits three eigenfrequencies and a good power output, particularly at the first eigenfrequency. (paper)

  2. Fungal mediated silver nanoparticle synthesis using robust experimental design and its application in cotton fabric

    Science.gov (United States)

    Velhal, Sulbha Girish; Kulkarni, S. D.; Latpate, R. V.

    2016-09-01

    Among the different methods employed for the synthesis of nanoparticles, the biological method is most favorable and quite well established. In microorganisms, use of fungi in the biosynthesis of silver nanoparticles has a greater advantage over other microbial mediators. In this study, intracellular synthesis of silver nanoparticles from Aspergillus terrerus (Thom) MTCC632 was carried out. We observed that synthesis of silver nanoparticles depended on factors such as temperature, amount of biomass and concentration of silver ions in the reaction mixture. Hence, optimization of biosynthesis using these parameters was carried out using statistical tool `robust experimental design'. Size and morphology of synthesized nanoparticles were determined using X-ray diffraction technique, field emission scanning electron microscopy, energy dispersion spectroscopy, and transmission electron microscopy. Nano-embedded cotton fabric was further prepared and studied for its antibacterial properties.

  3. Optimization design study of an innovative divertor concept for future experimental tokamak-type fusion reactors

    International Nuclear Information System (INIS)

    Willem Janssens, Ir.; Crutzen, Y.; Farfaletti-Casali, F.; Matera, R.

    1991-01-01

    The design optimization study of an innovative divertor concept for future experimental tokamak-type fusion devices is both an answer to the actual problems encountered in the multilayer divertor proposals and an illustration of a rational modelling philosophy and optimization strategy for the development of a new divertor structure. Instead of using mechanical attachment or metallurgical bonding of the protective material to the heat sink as in most actual divertor concepts, the so-called brush divertor in this study uses an array of unidirectional fibers penetrating in both the protective armor and the underling composite heat sink. Although the approach is fully concentrated on the divertor performance, including both a description of its function from the theoretical point of view and an overview of the problems related to the materials choice and evaluation, both the approach followed in the numerical modelling and the judgment of the results are thought to be valid also for other applications. Therefore the spin-off of the study must be situated in both the technological progress towards a feasible divertor solution, which introduces no additional physical uncertainties, and in the general area of the thermo-mechanical finite-element modelling on both macro-and microscale. The brush divertor itself embodies the use, and thus the modelling, of advanced materials such as tailor-made metal matrix composites and dispersion strengthened metals, and is shown to offer large potential advantages, demanding however and experimental validation under working conditions. It is clearly indicated where the need originates for an integrated experimental program which must allow to verify the basic modelling assumptions in order to arrive at the use of numerical computation as a powerful and realistic tool of structural testing and life-time prediction

  4. EXPERIMENTAL INVESTIGATIONS OF HORIZONTAL LATERAL STIFFNESS OF RAILS UNDER DIFFERENT DESIGNS OF RAIL FASTENERS

    Directory of Open Access Journals (Sweden)

    V. P. Velinets

    2015-11-01

    Full Text Available Purpose. Calculation of a railway track on the strength is one of the sections of the overall complex research problems of interaction track and rolling stock. This paper describes the experimental study of horizontal transverse stiffness of railway rails with various strands of rail fasteners. Materials of this article should be relevant and will make it possible to calculate the strength of railway track using the correct and corrected performance of horizontal transverse stiffness of rail threads. Methodology. Determination of horizontal transverse rigidity of rail yarns with different designs of rail fasteners was conducted by measuring the quantities of transverse displacement of rails calculation points – namely the head and sole. For research the specialist equipment was created, made up of lineside jack DC-20, equipped with a hydraulic pressure gauge to measure pressure and rigid rod for horizontal rail stop in the thread, the opposite of the jack. Lateral movement of the head and sole of the track were recorded, and measured with indicators of clock type within a few hundredths of a millimeter. The horizontal lateral load on the rail jack was created by the injection pressure in the cylinder which was fixed with manometer into the jack. Load of rails was conducted over 2 tons of degrees ranging from 0 to 8 tons. To obtain reliable measurement results of lateral movement of the head and the base rails, its movement was conducted for each type fasteners not less than in 3 sections. Measurements were carried out without the creation of vertical load. Findings. With the developed method was found transverse displacement magnitude of rails calculation points at different designs of rail fasteners. Originality. The experimental studies were first found the mentioned horizontal transverse stiffness of rail threads in the head and sole of modern designs for different rail fasteners. Practical value. The values of horizontal transverse

  5. Activating schoolyards: study design of a quasi-experimental schoolyard intervention study.

    Science.gov (United States)

    Andersen, Henriette Bondo; Pawlowski, Charlotte Skau; Scheller, Hanne Bebendorf; Troelsen, Jens; Toftager, Mette; Schipperijn, Jasper

    2015-05-31

    The aim of the Activating Schoolyards Study is to develop, implement, document and assess a comprehensive schoolyard intervention to promote physical activity (PA) during school recess for primary school children (grade 4-8). The intervention is designed to implement organizational and structural changes in the physical environment. The study builds on a quasi-experimental study design using a mixed method approach including: 1) an exploratory study aimed at providing input for the developing process; 2) an evaluation of the effect of the interventions using a combination of accelerometer, GPS and GIS; 3) a process evaluation facilitating the intervention development process and identifying barriers and facilitators in the implementation process; 4) a post-intervention end-user evaluation aimed at exploring who uses the schoolyards and how the schoolyards are used. The seven project schools (cases) were selected by means of an open competition and the interventions were developed using a participatory bottom-up approach. The participatory approach and case selection strategy make the study design novel. The use of a mixed methods design including qualitative as well as quantitative methods can be seen as a strength, as the different types of data complement each other and results of one part of the study informed the following parts. A unique aspect of our study is the use of accelerometers in combination with GPS and GIS in the effect evaluation to objectively determine where and how active the students are in the schoolyard, before and after the intervention. This provides a type of data that, to our knowledge, has not been used before in schoolyard interventions. Exploring the change in behavior in relation to specific intervention elements in the schoolyard will lead to recommendations for schools undergoing schoolyard renovations at some point in the future.

  6. Appropriate experimental design to evaluate preferences for microhabitat: an example of preferences by species of microgastropods.

    Science.gov (United States)

    Olabarria, C; Underwood, A; Chapman, M

    2002-07-01

    The intertidal microgastropods Eatoniella atropurpurea, Amphithalamus incidata and Eatonina rubrilabiata are principally found at mid- to low-shore levels in coralline turf and in patches of sediment close to algal turf on rocky shores. All three species are more abundant in coralline turf (i.e. algal beds composed primarily of Corallina officinalis Linnaeus, often containing patches of sediment) than in sediment, although the latter two are also quite abundant in patches of sediment. Eatoniella atropurpurea seem to live on branches of coralline algae, whereas Eatonina rubrilabiata and A. incidata seem to inhabit the sediment. In this study, we investigated whether or not behaviour of these animals accounts for the patterns observed in the field. Particularly, this study deals with choices amongst three microhabitats (coralline algae, coralline algae plus sediment and sediment) by these three species of microgastropods. Laboratory experiments were designed to examine preferences. The designs of such experiments are complex because demonstrating preference necessitates demonstrating different behaviour when confronted with choices from that showed when no choice is available. This study describes an appropriate series of hypotheses about preferences and experimental designs to test them. Preferences were indicated by differences in occupancy of the microhabitats when presented with a mixture and when each type is presented alone. In such experiments, snails did show preferences, except for A. incidata which did not show a pattern. Thus, the behaviour could, at least partially, account for the patterns of distribution in the field. The designs of experiments used here may be of value in other studies of preferences among habitats.

  7. Green Synthesis of Ultraviolet Absorber 2-Ethylhexyl Salicylate: Experimental Design and Artificial Neural Network Modeling

    Directory of Open Access Journals (Sweden)

    Shang-Ming Huang

    2017-11-01

    Full Text Available 2-Ethylhexyl salicylate, an ultraviolet filter, is widely used to protect skin against sunlight-induced harmful effects in the cosmetic industry. In this study, the green synthesis of 2-ethylhexyl salicylate using immobilized lipase through a solvent-free and reduced pressure evaporation system was investigated. A Box–Behnken design was employed to develop an artificial neural network (ANN model. The parameters for an optimal architecture of an ANN were set out: a quick propagation algorithm, a hyperbolic tangent transfer function, 10,000 iterations, and six nodes within the hidden layer. The best-fitting performance of the ANN was determined by the coefficient of determination and the root-mean-square error between the correlation of predicted and experimental data, indicating that the ANN displayed excellent data-fitting properties. Finally, the experimental conditions of synthesis were well established with the optimal parameters to obtain a high conversion of 2-ethylhexyl salicylate. In conclusion, this study efficiently replaces the traditional solvents with a green process for the synthesis of 2-ethylhexyl salicylate to avoid environmental contamination, and this process is well-modeled by a methodological ANN for optimization, which might be a benefit for industrial production.

  8. Investigation on gas medium parameters for an ArF excimer laser through orthogonal experimental design

    Science.gov (United States)

    Song, Xingliang; Sha, Pengfei; Fan, Yuanyuan; Jiang, R.; Zhao, Jiangshan; Zhou, Yi; Yang, Junhong; Xiong, Guangliang; Wang, Yu

    2018-02-01

    Due to complex kinetics of formation and loss mechanisms, such as ion-ion recombination reaction, neutral species harpoon reaction, excited state quenching and photon absorption, as well as their interactions, the performance behavior of different laser gas medium parameters for excimer laser varies greatly. Therefore, the effects of gas composition and total gas pressure on excimer laser performance attract continual research studies. In this work, orthogonal experimental design (OED) is used to investigate quantitative and qualitative correlations between output laser energy characteristics and gas medium parameters for an ArF excimer laser with plano-plano optical resonator operation. Optimized output laser energy with good pulse to pulse stability can be obtained effectively by proper selection of the gas medium parameters, which makes the most of the ArF excimer laser device. Simple and efficient method for gas medium optimization is proposed and demonstrated experimentally, which provides a global and systematic solution. By detailed statistical analysis, the significance sequence of relevant parameter factors and the optimized composition for gas medium parameters are obtained. Compared with conventional route of varying single gas parameter factor sequentially, this paper presents a more comprehensive way of considering multivariables simultaneously, which seems promising in striking an appropriate balance among various complicated parameters for power scaling study of an excimer laser.

  9. Experimental evaluation and set-up of a new apparatus designed for transitional flow experiments

    Directory of Open Access Journals (Sweden)

    Rozehnal Dalibor

    2012-04-01

    Full Text Available Experimental exercise has been conducted to validate the capability of a new test apparatus. The test stand has been designed and constructed at the laboratory of aerodynamics, University of Defence to carry out the experimental investigation of transitional flow prediction and development over flat plate. The test facility consists of a rectangular duct set on the suction side of air source apparatus. The working section is 2 m long with a cross section of 0.44 m in width and 0.25 m in height. The exercise is performed into two stages. In the first stage, the basic parameters such as freestream velocity, turbulence intensity and pressure gradient in streamwise direction were measured and manipulated to setup acceptable values. Second stage of the exercise, the bottom wall of the test section was used as a flat plate model to conduct turbulent boundary-layer experiment. The characteristics of the boundary layer obtained by using the apparatus are represented by a qualitative and quantitative agreement with those predicted by boundary-layer theory for turbulent boundary layer while more improvements seems to be required to satisfy the rules of boundary layer stability experiments. The results are show a fair agreement for mean velocity profile, U∞, boundary layer thickness, δ, momentum thickness, θ, and skin friction coefficient, Cf.

  10. Experimental design and reporting standards for metabolomics studies of mammalian cell lines.

    Science.gov (United States)

    Hayton, Sarah; Maker, Garth L; Mullaney, Ian; Trengove, Robert D

    2017-12-01

    Metabolomics is an analytical technique that investigates the small biochemical molecules present within a biological sample isolated from a plant, animal, or cultured cells. It can be an extremely powerful tool in elucidating the specific metabolic changes within a biological system in response to an environmental challenge such as disease, infection, drugs, or toxins. A historically difficult step in the metabolomics pipeline is in data interpretation to a meaningful biological context, for such high-variability biological samples and in untargeted metabolomics studies that are hypothesis-generating by design. One way to achieve stronger biological context of metabolomic data is via the use of cultured cell models, particularly for mammalian biological systems. The benefits of in vitro metabolomics include a much greater control of external variables and no ethical concerns. The current concerns are with inconsistencies in experimental procedures and level of reporting standards between different studies. This review discusses some of these discrepancies between recent studies, such as metabolite extraction and data normalisation. The aim of this review is to highlight the importance of a standardised experimental approach to any cultured cell metabolomics study and suggests an example procedure fully inclusive of information that should be disclosed in regard to the cell type/s used and their culture conditions. Metabolomics of cultured cells has the potential to uncover previously unknown information about cell biology, functions and response mechanisms, and so the accurate biological interpretation of the data produced and its ability to be compared to other studies should be considered vitally important.

  11. Design and Field Experimentation of a Cooperative ITS Architecture Based on Distributed RSUs †

    Science.gov (United States)

    Moreno, Asier; Osaba, Eneko; Onieva, Enrique; Perallos, Asier; Iovino, Giovanni; Fernández, Pablo

    2016-01-01

    This paper describes a new cooperative Intelligent Transportation System architecture that aims to enable collaborative sensing services. The main goal of this architecture is to improve transportation efficiency and performance. The system, which has been proven within the participation in the ICSI (Intelligent Cooperative Sensing for Improved traffic efficiency) European project, encompasses the entire process of capture and management of available road data. For this purpose, it applies a combination of cooperative services and methods for data sensing, acquisition, processing and communication amongst road users, vehicles, infrastructures and related stakeholders. Additionally, the advantages of using the proposed system are exposed. The most important of these advantages is the use of a distributed architecture, moving the system intelligence from the control centre to the peripheral devices. The global architecture of the system is presented, as well as the software design and the interaction between its main components. Finally, functional and operational results observed through the experimentation are described. This experimentation has been carried out in two real scenarios, in Lisbon (Portugal) and Pisa (Italy). PMID:27455277

  12. Experimental study on design verification of new concept for integral reactor safety system

    International Nuclear Information System (INIS)

    Chung, Moon Ki; Choi, Ki Yong; Park, Hyun Sik; Cho, Seok; Park, Choon Kyung; Lee, Sung Jae; Song, Chul Hwa

    2004-01-01

    The pressurized light water cooled, medium power (330 MWt) SMART (System-integrated Modular Advanced ReacTor) has been under development at KAERI for a dual purpose : seawater desalination and electricity generation. The SMART design verification phase was followed to conduct various separate effects tests and comprehensive integral effect tests. The high temperature / high pressure thermal-hydraulic test facility, VISTA(Experimental Verification by Integral Simulation of Transient and Accidents) has been constructed to simulate the SMART-P (the one fifth scaled pilot plant) by KAERI. Experimental tests have been performed to investigate the thermal-hydraulic dynamic characteristics of the primary and the secondary systems. Heat transfer characteristics and natural circulation performance of the PRHRS (Passive Residual Heat Removal System) of SMART-P were also investigated using the VISTA facility. The coolant flows steadily in the natural circulation loop which is composed of the Steam Generator (SG) primary side, the secondary system, and the PRHRS. The heat transfers through the PRHRS heat exchanger and ECT are sufficient enough to enable the natural circulation of the coolant

  13. Inferring the temperature dependence of population parameters: the effects of experimental design and inference algorithm.

    Science.gov (United States)

    Palamara, Gian Marco; Childs, Dylan Z; Clements, Christopher F; Petchey, Owen L; Plebani, Marco; Smith, Matthew J

    2014-12-01

    Understanding and quantifying the temperature dependence of population parameters, such as intrinsic growth rate and carrying capacity, is critical for predicting the ecological responses to environmental change. Many studies provide empirical estimates of such temperature dependencies, but a thorough investigation of the methods used to infer them has not been performed yet. We created artificial population time series using a stochastic logistic model parameterized with the Arrhenius equation, so that activation energy drives the temperature dependence of population parameters. We simulated different experimental designs and used different inference methods, varying the likelihood functions and other aspects of the parameter estimation methods. Finally, we applied the best performing inference methods to real data for the species Paramecium caudatum. The relative error of the estimates of activation energy varied between 5% and 30%. The fraction of habitat sampled played the most important role in determining the relative error; sampling at least 1% of the habitat kept it below 50%. We found that methods that simultaneously use all time series data (direct methods) and methods that estimate population parameters separately for each temperature (indirect methods) are complementary. Indirect methods provide a clearer insight into the shape of the functional form describing the temperature dependence of population parameters; direct methods enable a more accurate estimation of the parameters of such functional forms. Using both methods, we found that growth rate and carrying capacity of Paramecium caudatum scale with temperature according to different activation energies. Our study shows how careful choice of experimental design and inference methods can increase the accuracy of the inferred relationships between temperature and population parameters. The comparison of estimation methods provided here can increase the accuracy of model predictions, with important

  14. Molten Core - Concrete interactions in nuclear accidents. Theory and design of an experimental facility

    International Nuclear Information System (INIS)

    Sevon, T.

    2005-11-01

    In a hypothetical severe accident in a nuclear power plant, the molten core of the reactor may flow onto the concrete floor of containment building. This would cause a molten core . concrete interaction (MCCI), in which the heat transfer from the hot melt to the concrete would cause melting of the concrete. In assessing the safety of nuclear reactors, it is important to know the consequences of such an interaction. As background to the subject, this publication includes a description of the core melt stabilization concept of the European Pressurized water Reactor (EPR), which is being built in Olkiluoto in Finland. The publication includes a description of the basic theory of the interaction and the process of spalling or cracking of concrete when it is heated rapidly. A literature survey and some calculations of the physical properties of concrete and corium. concrete mixtures at high temperatures have been conducted. In addition, an equation is derived for conservative calculation of the maximum possible concrete ablation depth. The publication also includes a literature survey of experimental research on the subject of the MCCI and discussion of the results and deficiencies of the experiments. The main result of this work is the general design of an experimental facility to examine the interaction of molten metals and concrete. The main objective of the experiments is to assess the probability of spalling, or cracking, of concrete under pouring of molten material. A program of five experiments has been designed, and pre-test calculations of the experiments have been conducted with MELCOR 1.8.5 accident analysis program and conservative analytic calculations. (orig.)

  15. Experimental design of diffusion and desorption of contaminant in heterogeneous media.

    Science.gov (United States)

    Jiang, Guannan; Crimi, Michelle; Fowler, Kathleen; Fu, Xiaojing

    2011-01-01

    Storage of contaminants in low permeability media (LPM) presents a great challenge for prediction of remediation effectiveness and efficiency. The reason lies in the contaminants' complex behaviors within heterogeneous media. Both interparticle and intraparticle diffusion contribute to the difficulty of precise site assessment. Sorption of contaminants--especially within LPM--may sequester the contaminants from active treatment, while desorption over a long period of time leads to contaminant release from storage and consequent re-contamination. Research has been conducted toward better understanding of contaminant diffusion and sorption/desorption processes to better predict contaminant response to site treatment. However, most of the research has been carried out within homogeneous media, while real scenarios in environmental problems feature media whose permeability and other characteristics vary significantly over the treatment volume. Further, few efforts have combined the interparticle/intraparticle diffusion and sorption/desorption processes together. This research aims at a feasible experimental design of diffusion and desorption of contaminant in heterogeneous media to address the gaps in previous research. A 2-D experimental system was designed to evaluate interparticle/intraparticle diffusion processes of trichloroethylene (TCE) in heterogeneous media. The 2-D system was modified to include organic matter in media for simulation of sorption/desorption processes. Results of the research will improve the understanding of how these different transport processes act together within heterogeneous media. Results will also allow for the evaluation of the impact of contaminant mass transport from within low permeability media at a potential treatment site and can support the development of mathematical tools/models combining interparticle/intraparticle and sorption/desorption processes. Such a model will promote more accurate site assessment and provide more

  16. Quasi-experimental study designs series-paper 11: supporting the production and use of health systems research syntheses that draw on quasi-experimental study designs.

    Science.gov (United States)

    Lavis, John N; Bärnighausen, Till; El-Jardali, Fadi

    2017-09-01

    To describe the infrastructure available to support the production of policy-relevant health systems research syntheses, particularly those incorporating quasi-experimental evidence, and the tools available to support the use of these syntheses. Literature review. The general challenges associated with the available infrastructure include their sporadic nature or limited coverage of issues and countries, whereas the specific ones related to policy-relevant syntheses of quasi-experimental evidence include the lack of mechanism to register synthesis titles and scoping review protocols, the limited number of groups preparing user-friendly summaries, and the difficulty of finding quasi-experimental studies for inclusion in rapid syntheses and research syntheses more generally. Although some new tools have emerged in recent years, such as guidance workbooks and citizen briefs and panels, challenges related to using available tools to support the use of policy-relevant syntheses of quasi-experimental evidence arise from such studies potentially being harder for policymakers and stakeholders to commission and understand. Policymakers, stakeholders, and researchers need to expand the coverage and institutionalize the use of the available infrastructure and tools to support the use of health system research syntheses containing quasi-experimental evidence. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Used frying oil biodiesel production: experimental factorial design and multivariate analysis

    Directory of Open Access Journals (Sweden)

    Rosana de Cassia de Souza Schneider

    2009-01-01

    Full Text Available Biodiesel é derivado de fontes renováveis ereduz significativamente as emissões atmosféricas. Pode serobtido de diversos processos, como a alcoolise. Nestetrabalho, o biodiesel foi produzido através da alcoolise doóleo de fritura usado de indústrias de alimentação. Umplanejamento experimental foi utilizado e os produtos dereação foram analisados por cromatografia gasosa (CGespectroscopia na região do infravermelho com acessório dereflexão total atenuada horizontal (IV-HATR e análiseexploratória por análise de componentes principais (PCA eanálise hierárquica de grupos (HCA. De acordo com ascondições analisadas obteve-se alta conversão em ésteresmetílicos. Por IV-HATR, a conversão máxima foi observadaem condições experimentais de temperatura ( 50 e 60°C,concentração de catalisador (0,6 e 1,2% e a 1:8 de relaçãomolar entre óleo e metanol. Também foi possíveldiscriminar por análise quimiométrica, 4 grupos noplanejamento experimental e determinar as melhorescondições para a produção de biodiesel de óleo de friturausado.Abstract Biodiesel is derived from renewable sources and it significantly reduces atmospheric emissions. It can be obtained byseveral processes, such as alcoholysis. In this work, biodiesel was produced through alcoholysis of used frying oil from a cateringbusiness. An experimental factorial design was used and the reaction products were analyzed through gas chromatography (GC,horizontal attenuated total reflection Fourier transform infrared (HATR/FT-IR spectroscopy and exploratory analysis withprincipal component analysis (PCA and hierarchical cluster analysis (HCA. Under the conditions analyzed, a high degree ofconversion to methyl ester was found. As shown by HATR/FT-IR, the maximum conversion was obtained when the experimentalconditions had the temperature ( 50 e 60°C, largest catalyst concentration (0,6 e 1,2% and a 1:8 molar proportion of oil tomethanol. It was possible to discriminate

  18. Computational Design of Creep-Resistant Alloys and Experimental Validation in Ferritic Superalloys

    Energy Technology Data Exchange (ETDEWEB)

    Liaw, Peter

    2014-12-31

    A new class of ferritic superalloys containing B2-type zones inside parent L21-type precipitates in a disordered solid-solution matrix, also known as a hierarchical-precipitate strengthened ferritic alloy (HPSFA), has been developed for high-temperature structural applications in fossil-energy power plants. These alloys were designed by the addition of the Ti element into a previously-studied NiAl-strengthened ferritic alloy (denoted as FBB8 in this study). In the present research, systematic investigations, including advanced experimental techniques, first-principles calculations, and numerical simulations, have been integrated and conducted to characterize the complex microstructures and excellent creep resistance of HPSFAs. The experimental techniques include transmission-electron microscopy, scanningtransmission- electron microscopy, neutron diffraction, and atom-probe tomography, which provide detailed microstructural information of HPSFAs. Systematic tension/compression creep tests revealed that HPSFAs exhibit the superior creep resistance, compared with the FBB8 and conventional ferritic steels (i.e., the creep rates of HPSFAs are about 4 orders of magnitude slower than the FBB8 and conventional ferritic steels.) First-principles calculations include interfacial free energies, anti-phase boundary (APB) free energies, elastic constants, and impurity diffusivities in Fe. Combined with kinetic Monte- Carlo simulations of interdiffusion coefficients, and the integration of computational thermodynamics and kinetics, these calculations provide great understanding of thermodynamic and mechanical properties of HPSFAs. In addition to the systematic experimental approach and first-principles calculations, a series of numerical tools and algorithms, which assist in the optimization of creep properties of ferritic superalloys, are utilized and developed. These numerical simulation results are compared with the available experimental data and previous first

  19. Design and experimental characterization of a 350 W High Temperature PEM fuel cell stack

    Directory of Open Access Journals (Sweden)

    Nicola Zuliani

    2011-01-01

    Full Text Available High Temperature Proton Exchange Membrane (HT PEM fuel cell based on polybenzimidazole (PBI polymer and phosphoric acid, can be operated at temperature between 120 °C and 180 °C. Reactants humidification is not required and CO content up to 2% in the fuel can be tolerated, affecting only marginally performance. This is what makes HT PEM very attractive, as low quality reformed hydrogen can be used and water management problems are avoided. Till nowadays, from experimental point of view, only few studies relate to the development and characterization of high temperature stacks. The aim of this work is to present the main design features and the performance curves of a 25 cells HT PEM stack based on PBI and phosphoric acid membranes. Performance curves refer to the stack operating with two type of fuels: pure hydrogen and a gas mixture simulating a typical steam reformer output. The stack voltage distribution analysis and the stack temperature distribution analysis suggest that cathode air could be used as coolant leading to a better thermal management. This could simplify stack design and system BOP, thus increasing system performance.

  20. Experimental design in formulation of diazepam nanoemulsions: physicochemical and pharmacokinetic performances.

    Science.gov (United States)

    Đorđević, Sanela M; Radulović, Tamara S; Cekić, Nebojša D; Ranđelović, Danijela V; Savić, Miroslav M; Krajišnik, Danina R; Milić, Jela R; Savić, Snežana D

    2013-11-01

    With the aid of experimental design, we developed and characterized nanoemulsions for parenteral drug delivery. Formulations containing a mixture of medium-chain triglycerides and soybean oil as oil phase, lecithin (soybean/egg) and polysorbate 80 as emulsifiers, and 0.1 M phosphate buffer solution (pH 8) as aqueous phase were prepared by cold high-pressure homogenization. To study the effects of the oil content, lecithin type, and the presence of diazepam as a model drug and their interactions on physicochemical characteristics of nanoemulsions, a three factor two-level full factorial design was applied. The nanoemulsions were evaluated concerning droplet size and size distribution, surface charge, viscosity, morphology, drug-excipient interactions, and physical stability. The characterization revealed the small spherical droplets in the range 195 -220 nm with polydispersity index below 0.15 and zeta potential between -30 and - 60 mV. Interactions among the investigated factors, rather than factors alone, were shown to more profoundly affect nanoemulsion characteristics. In vivo pharmacokinetic study of selected diazepam nanoemulsions with different oil content (20%, 30%, and 40%, w/w) demonstrated fast and intense initial distribution into rat brain of diazepam from nanoemulsions with 20% and 30% (w/w) oil content, suggesting their applicability in urgent situations. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association.

  1. Fuzzy Supervisor Approach Design Based-Switching Controller for Pumping Station: Experimental Validation

    Directory of Open Access Journals (Sweden)

    Wael Chakchouk

    2017-01-01

    Full Text Available This paper proposes a discrete-time switching controller strategy for a hydraulic process pumping station. The proposed solution leads to improving control system performances with two tests: combination of Fuzzy-PD and PI controllers and Fuzzy-PID and PI controllers. The proposed design methodology is based on accurate model for pumping station (PS, which is developed in previous works using Fuzzy-C Means (FCM algorithm. The control law design is based on switching control; a fuzzy supervisor manages the switching from one to another and regulates the rate of participation of each order, in order to satisfy various objectives of a stable pumping station like the asymptotic stability of the tracking error. To validate the proposed solution, experimental tests are made and analyzed. Compared to the conventional PI and fuzzy logic (FL approaches, the results show that the switching controller allows exhibiting excellent transient response over a wide range of operating conditions and especially is easier to be implemented in practice.

  2. Statistical experimental design to assess the influence of enzymes of nematophagous fungi versus helminths.

    Science.gov (United States)

    Braga, Fabio Ribeiro; de Freitas Soares, Filippe Elias; Araujo, Juliana Milani; da Fonseca, Leandro Abreu; Hiura, Emy; Garschagen Gava, Maylla; Toledo Vieira, Fernanda; da Paz, Jeanne Saraiva; de Carvalho, Lorendane Milena; Faccini, João Victor; de Queiroz, José Humberto; Araújo, Jackson Victor

    2014-12-01

    The present work used Plackett-Burman experimental design to assess the influence of enzymes of nematophagous fungi versus Strongyloides westeri and trichostrongylides larvae and Platynosomum fastosum eggs. The variables studied in the Plackett-Burman design were the proteases and chitinases of AC001 or VC4 as destructive agents of S. westeri and trichostrongylides larvae, and P. fastosum eggs. All tested enzymes had a significant effect (P < 0.05) on the destruction of S. westeri larvae. Furthermore, only VC4 and AC001 proteases showed a significant effect (P < 0.05) on the destruction of trichostrongylides larvae. On the other hand, chitinases of VC4 showed the highest significance (P < 0.05) on the destruction of P. fastosum eggs. It is proposed that statistical planning for the use of enzymes derived from nematophagous fungi is a viable way to elucidate some questions about their mechanism of action. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Electrodialytic desalination of brackish water: determination of optimal experimental parameters using full factorial design

    Science.gov (United States)

    Gmar, Soumaya; Helali, Nawel; Boubakri, Ali; Sayadi, Ilhem Ben Salah; Tlili, Mohamed; Amor, Mohamed Ben

    2017-12-01

    The aim of this work is to study the desalination of brackish water by electrodialysis (ED). A two level-three factor (23) full factorial design methodology was used to investigate the influence of different physicochemical parameters on the demineralization rate (DR) and the specific power consumption (SPC). Statistical design determines factors which have the important effects on ED performance and studies all interactions between the considered parameters. Three significant factors were used including applied potential, salt concentration and flow rate. The experimental results and statistical analysis show that applied potential and salt concentration are the main effect for DR as well as for SPC. The effect of interaction between applied potential and salt concentration was observed for SPC. A maximum value of 82.24% was obtained for DR under optimum conditions and the best value of SPC obtained was 5.64 Wh L-1. Empirical regression models were also obtained and used to predict the DR and the SPC profiles with satisfactory results. The process was applied for the treatment of real brackish water using the optimal parameters.

  4. Design study of an armor tile handling manipulator for the Fusion Experimental Reactor

    International Nuclear Information System (INIS)

    Shibanuma, K.; Honda, T.; Satoh, K.; Terakado, T.; Kondoh, M.; Sasaki, N.; Munakata, T.; Murakami, S.

    1991-01-01

    A conceptual design of the Fusion Experimental Reactor (FER), which is a D-T burning reactor following on JT-60 in Japan, has been developed by Japan Atomic Energy Research Institute (JAERI). In FER, a rail-mounted vehicle concept is planned to be adopted for in-vessel maintenance, such as maintenance of divertor plates and armor tiles. Advantages of this concept are the high stiffness of the rail as a base structure for maintenance and the high mobility of the vehicle along the rail. Twin armor tile handling manipulators installed on both sides of the vehicle have been designed. The respective manipulators for armor tile handling have 8 degrees of freedom in order to have access to any place of the first wall and to go through the horizontal port by operating manipulator joints. If the two types of manipulators for divertor plates and armor tiles are installed on the vehicle and the divertor handling manipulator carries a case filled with armor tiles, the replacement time of armor tiles will be reduced. In FER, moreover, maintenance of armor tiles, which is a scheduled maintenance, is planned to be carried out by the autonomous control using position sensors etc. In order to accumulate the data base for the development of the autonomous control of the manipulator in armor tile maintenance, the present paper describes basic mechanical characteristics (stress, deflection and natural frequency) of the armor tile handling manipulator calculated by static stress and dynamic eigenvalue analyses. (orig.)

  5. Experimental evaluation of torsional fatigue strength of welded bellows and application to design of fusion device

    International Nuclear Information System (INIS)

    Takatsu, Hideyuki; Yamamoto, Masahiro; Shimizu, Masatsugu; Suzuki, Kazuo; Sonobe, Tadashi; Hayashi, Yuzo; Mizuno, Gen-ichiro.

    1984-01-01

    Torsional fatigue strength of the welded bellows was evaluated experimentally, aiming the application to a port of a fusion device. The welded bellows revealed elastic torsional buckling and spiral distorsion even under a small angle of torsion. Twisting load never leads the welded bellows to fracture easily so far as the angle of torsion is not excessively large, and the welded bellows has the torsional fatigue strength much larger than that expected so far. Two formulae were proposed to evaluate the stress of the welded bellows under the forced angle of torsion; shearing stress evaluation formula in the case that torsional buckling does not occur and the axial bending stress evaluation formula in the case that torsional buckling occurs. And the results of the torsional fatigue experiments showed that the former is reasonably conservative and simulates the actual behavior of the welded bellows better than the latter in the high cycle fatigue region and vice versa in the low cycle fatigue region from the viewpoint of the mechanical design. The present evaluation method of the torsional fatigue strength was applied to the welded bellows for the port of the JT-60 vacuum vessel and its structural integrity was confirmed under the design load condition. (author)

  6. The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation.

    Science.gov (United States)

    Maček Hrvat, Nikolina; Zorbaz, Tamara; Šinko, Goran; Kovarik, Zrinka

    2017-11-24

    Reactivation of acetylcholinesterase (AChE), an essential enzyme in neurotransmission, is a key point in the treatment of acute poisoning by nerve agents and pesticides, which structurally belong to organophosphorus compounds (OP). Due to the high diversity of substituents on the phosphorous atom, there is a variety of OP-AChE conjugates deriving from AChE inhibition, and therefore not only is there no universal reactivator efficient enough for the most toxic OPs, but for some nerve agents there is still a lack of any reactivator at all. The endeavor of many chemists to find more efficient reactivators resulted in thousands of newly-designed and synthesized oximes-potential reactivators of AChE. For an evaluation of the oximés reactivation efficiency, many research groups employ a simple spectrophotometric Ellman method. Since parameters that describe reactivator efficiency are often incomparable among laboratories, we tried to emphasize the critical steps in the determination of reactivation parameters as well as in the experimental design of a reactivation assay. We highlighted the important points in evaluation of reactivation kinetic parameters with an aim to achieve better agreement and comparability between the results obtained by different laboratories and overall, a more efficient evaluation of in vitro reactivation potency. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Optimizing the experimental design of soil columns in saturated and unsaturated transport experiments.

    Science.gov (United States)

    Lewis, Jeffrey; Sjöstrom, Jan

    2010-06-25

    Soil column experiments in both the saturated and unsaturated regimes are widely used for applied and theoretical studies in such diverse fields as transport model evaluation, fate and transport of pesticides, explosives, microbes, heavy metals and non aqueous phase liquids, and for evapotranspiration studies. The apparent simplicity of constructing soil columns conceals a number of technical issues which can seriously affect the outcome of an experiment, such as the presence or absence of macropores, artificial preferential flow paths, non-ideal infiltrate injection and unrealistic moisture regimes. This review examines the literature to provide an analysis of the state of the art for constructing both saturated and unsaturated soil columns. Common design challenges are discussed and best practices for potential solutions are presented. This article discusses both basic principles and the practical advantages and disadvantages of various experimental approaches. Both repacked and monolith-type columns are discussed. The information in this review will assist soil scientists, hydrogeologists and environmental professionals in optimizing the construction and operation of soil column experiments in order to achieve their objectives, while avoiding serious design flaws which can compromise the integrity of their results. 2010 Elsevier B.V. All rights reserved.

  8. Mechatronics design and experimental verification of an electric-vehicle-based hybrid thermal management system

    Directory of Open Access Journals (Sweden)

    Yi-Hsuan Hung

    2016-02-01

    Full Text Available In this study, an electric-vehicle-based thermal management system was designed for dual energy sources. An experimental platform developed in a previous study was modified. Regarding the mechanical components, a heat exchanger with a radiator, proportional valve, coolant pipes, and coolant pump was appropriately integrated. Regarding the electric components, two heaters emulating waste heat were controlled using two programmable power supply machines. A rapid-prototyping controller with two temperature inputs and three outputs was designed. Rule-based control strategies were coded to maintain optimal temperatures for the emulated proton exchange membrane fuel cells and lithium batteries. To evaluate the heat power of dual energy sources, driving cycles, energy management control, and efficiency maps of energy sources were considered for deriving time-variant values. The main results are as follows: (a an advanced mechatronics platform was constructed; (b a driving cycle simulation was successfully conducted; and (c coolant temperatures reached their optimal operating ranges when the proportional valve, radiator, and coolant pump were sequentially controlled. The benefits of this novel electric-vehicle-based thermal management system are (a high-efficiency operation of energy sources, (b low occupied volume integrated with energy sources, and (c higher electric vehicle traveling mileage. This system will be integrated with real energy sources and a real electric vehicle in the future.

  9. Minimizing Experimental Setup Time and Effort at APS beamline 1-ID through Instrumentation Design

    Energy Technology Data Exchange (ETDEWEB)

    Benda, Erika; Almer, Jonathan; Kenesei, Peter; Mashayekhi, Ali; Okasinksi, John; Park, Jun-Sang; Ranay, Rogelio; Shastri, Sarvijt

    2016-01-01

    Sector 1-ID at the APS accommodates a number of dif-ferent experimental techniques in the same spatial enve-lope of the E-hutch end station. These include high-energy small and wide angle X-ray scattering (SAXS and WAXS), high-energy diffraction microscopy (HEDM, both near and far field modes) and high-energy X-ray tomography. These techniques are frequently combined to allow the users to obtain multimodal data, often attaining 1 μm spatial resolution and <0.05º angular resolution. Furthermore, these techniques are utilized while the sam-ple is thermo-mechanically loaded to mimic real operat-ing conditions. The instrumentation required for each of these techniques and environments has been designed and configured in a modular way with a focus on stability and repeatability between changeovers. This approach allows the end station to be more versatile, capable of collecting multi-modal data in-situ while reducing time and effort typically required for set up and alignment, resulting in more efficient beam time use. Key instrumentation de-sign features and layout of the end station are presented.

  10. Optimization of the pelletization process in a fluid-bed rotor granulator using experimental design.

    Science.gov (United States)

    Korakianiti, E S; Rekkas, D M; Dallas, P P; Choulis, N H

    2000-12-01

    This study examined the effect of rotor speed, amount of water sprayed, and atomizing air pressure on the geometric mean diameter and geometric standard deviation of pellets produced in a fluid-bed rotor granulator using a 23 factorial design and an optimization technique. Pellets were prepared by wet granulation. Equal amounts of microcrystalline cellulose, alpha-lactose monohydrate, and distilled water were used as the granulation liquid. The size and the size distribution of the pellets were determined by sieve analysis. The size of the pellets was found to be dependent on the amount of water added, while an increase in rotor speed decreased their size. Both factors were found to be statistically significant (P pellet size was not statistically significant. None of the 3 factors significantly affected the geometric standard deviation of the pellets. The rotor speed and the amount of water sprayed were further selected in order to construct a mathematical model that correlates these factors with the geometric mean diameter of the pellets. For this purpose, the optimization technique 3(2) was used. The derived equation described the relationship between the selected factors and the size of the pellets. As a result, the experimental design techniques applied were found to be suitable in optimizing the pelletization process carried out in a fluid-bed rotor granulator.

  11. Aligning experimental design with bioinformatics analysis to meet discovery research objectives.

    Science.gov (United States)

    Kane, Michael D

    2002-01-01

    The utility of genomic technology and bioinformatic analytical support to provide new and needed insight into the molecular basis of disease, development, and diversity continues to grow as more research model systems and populations are investigated. Yet deriving results that meet a specific set of research objectives requires aligning or coordinating the design of the experiment, the laboratory techniques, and the data analysis. The following paragraphs describe several important interdependent factors that need to be considered to generate high quality data from the microarray platform. These factors include aligning oligonucleotide probe design with the sample labeling strategy if oligonucleotide probes are employed, recognizing that compromises are inherent in different sample procurement methods, normalizing 2-color microarray raw data, and distinguishing the difference between gene clustering and sample clustering. These factors do not represent an exhaustive list of technical variables in microarray-based research, but this list highlights those variables that span both experimental execution and data analysis. Copyright 2001 Wiley-Liss, Inc.

  12. Design of the Grimethorpe Experimental Facility as of March 1981: a technical report

    Energy Technology Data Exchange (ETDEWEB)

    1984-06-01

    The Experimental Pressurized Fluidized Bed Combustor, which has been built as an extension to the National Coal Board Power Station, which is adjacent to Grimethorpe Colliery, Yorkshire, England, is described in this report. The Governments of the United Kingdom, the United States of America and the Federal Republic of Germany, under the auspices of the International Energy Agency, have agreed to share equally between them the costs of building and operating the plant. Control of the project was vested in an Executive Committee consisting of one representative of each Government with all decisions requiring unanimity. The actual operation of the project was vested in an Operating Agent, NCB (IEA Services) Ltd., a wholly owned subsidiary of the National Coal Board. The Implementing Agreement envisages a seven year project to be executed in four stages: (1) Procurement of Design Study with accompanying tender documents. (2) Tendering for construction of the Plant; study of appraisal of tenders. (3) Construction and acceptance of the Plant. (4) Operation of the Plant. The project is now towards the end of Stage 3. Construction has been completed and commissioning is in progress to prepare the plant for the start of the operational phase in Autumn 1981. Because of the confidentiality of much of the design information, for the purposes of this report technical descriptions have been confined to that of a general appraisal.

  13. An efficient approach to bioconversion kinetic model generation based on automated microscale experimentation integrated with model driven experimental design

    DEFF Research Database (Denmark)

    Chen, B. H.; Micheletti, M.; Baganz, F.

    2009-01-01

    Reliable models of enzyme kinetics are required for the effective design of bioconversion processes. Kinetic expressions of the enzyme-catalysed reaction rate however, are frequently complex and establishing accurate values of kinetic parameters normally requires a large number of experiments. Th...

  14. Experimental design optimisation: theory and application to estimation of receptor model parameters using dynamic positron emission tomography

    International Nuclear Information System (INIS)

    Delforge, J.; Syrota, A.; Mazoyer, B.M.

    1989-01-01

    General framework and various criteria for experimental design optimisation are presented. The methodology is applied to estimation of receptor-ligand reaction model parameters with dynamic positron emission tomography data. The possibility of improving parameter estimation using a new experimental design combining an injection of the β + -labelled ligand and an injection of the cold ligand is investigated. Numerical simulations predict remarkable improvement in the accuracy of parameter estimates with this new experimental design and particularly the possibility of separate estimations of the association constant (k +1 ) and of receptor density (B' max ) in a single experiment. Simulation predictions are validated using experimental PET data in which parameter uncertainties are reduced by factors ranging from 17 to 1000. (author)

  15. In-Service Performance and Costs of Methods for Control of Urban Rail System Noise : Experimental Design

    Science.gov (United States)

    1976-05-01

    This report presents an experimental design for a project to evaluate four techniques for reducing wheel-rail noise on urban rail transit systems: (a) resilient wheels, (b) damped wheels, (c) wheel truing, and (d) rail griding. The design presents th...

  16. Design and experimental investigation of an oxy-fuel combustion system for magnetohydrodynamic power extraction

    Science.gov (United States)

    Hernandez, Manuel Johannes

    designed to produce gas velocities of 2000 m/s gas and temperatures within the following range of 2800-3000 K. In the injection system, the momentum flux ratio (MFR) was estimated to be 16. The heat loss fraction in this oxy-combustion system, based on CFD and analytical calculations, at optimal operating conditions, was estimated to be less than 10 percent. Furthermore, the heat transfer design removed approximately 7 MW/m2. The experimental performance of oxy-combustion systems demonstrates promise for advanced power generation applications.

  17. Formulation and optimization of microemulsion-based organogels containing propranolol hydrochloride using experimental design methods

    Directory of Open Access Journals (Sweden)

    N Hadidi

    2009-10-01

    Full Text Available "n "nBackground and the purpose of the study:Lecithin organogels are formed spontaneously by adding a given amount of water to lecithin/organic solvent mixture. The aim of this research was to develop and optimize a semisolid preparation with appropriate release profile. "nMethods: Lecithin organogels containing Propranolol hydrochloride (PR were formulated, based on phase diagram studies, using soybean lecithin (Epikuron 200, isopropyl myristate (IPM and propranolol hydrochloride (PR solutions ( 10, 20, 30, 50 % w/w or water at various lecithin/ IPM weight ratios. The flux and the viscosity of the prepared formulations were determined and further chosen as two responses for optimization, using experimental design and optimization methods (i.e. Modified Simplex and Central Composite Designs, respectively. Results of modified simplex runs (i.e. lecithin: 30-50%, PR: 20-40% and water: 3-4% were also used as constraints for constructing central composite design space. The numerical and graphical optimizations were then run and the "sweet spot" corresponding to the most desirable formulation region compromising both responses were achieved. "nResults: Phase diagrams showed a narrow area of existence of non-birefringent, transparent, viscoelastic region, which was extended as %PR incorporated into the system was increased. It was observed that as the lecithin concentration increased from 30 to 60 % w/w, drug incorporation capacity and viscosity increased while the flux of PR from organogels decreased remarkably. Also it was found through optimization that among the organogels investigated, those formulations containing 31.5-37.5 % w/w lecithin, 30.5-34.5 % w/w PR solutions and 3-3.35 % w/w water possessed the highest flux. "nMajor conclusion: Data confirmed that the choice of lecithin/IPM weight ratio and the amount of drug incorporated may be crucial in determining the performance of an organogel.

  18. Study of Abrasion of Rubber Materials by Experimental Design, Response Surface and Artificial Neural Network Modeling

    Directory of Open Access Journals (Sweden)

    Mehdi Shiva

    2015-07-01

    Full Text Available Effect of different formulation ingredients on the abrasion behavior, crack growth and modulus of tire tread formulation was studied using two different case studies. In the first case study, the effect of the partial substitution of natural rubber by cis-butadiene and the content variation of oil and sulfur in the presence of modified clay was studied on the basis of central composite design experiment in a NR/SBR-based truck tire tread formulation. In the second case study, the effect of oil, sulfur and highly dispersible silica level was investigated via Box-Benken design experiment in a SBR/BR-based passenger tire tread formulation. In each study a suitable response surface model was developed on the basis of the data obtained using the experimental design. Artificial neural network models with forwarding multi-layers were also developed to investigate the potential of the current approach in modeling of fracture behavior of rubber materials. It was observed that the complex dependency of the fracture/abrasion behavior of rubbery materials on formulation variations could be modeled with high accuracy through response surface and artificial neural models. The response surface profiles were developed to explain the abrasion behavior better. The observed behaviors for the abrasion of rubber formulations were also investigated with the aid of the modulus statistical analysis, deMattia crack growth model and also the Fukahori and mechano-chemical abrasion theories. In the presence of high levels of cis-butadiene, the abrasion with the mechano-chemical mechanism is dominant. However, according to the Fukahori model, the mean amplitude strain has a key effect on the abrasion of rubbery materials.

  19. Design of an experimental four-camera setup for enhanced 3D surface reconstruction in microsurgery

    Directory of Open Access Journals (Sweden)

    Marzi Christian

    2017-09-01

    Full Text Available Future fully digital surgical visualization systems enable a wide range of new options. Caused by optomechanical limitations a main disadvantage of today’s surgical microscopes is their incapability of providing arbitrary perspectives to more than two observers. In a fully digital microscopic system, multiple arbitrary views can be generated from a 3D reconstruction. Modern surgical microscopes allow replacing the eyepieces by cameras in order to record stereoscopic videos. A reconstruction from these videos can only contain the amount of detail the recording camera system gathers from the scene. Therefore, covered surfaces can result in a faulty reconstruction for deviating stereoscopic perspectives. By adding cameras recording the object from different angles, additional information of the scene is acquired, allowing to improve the reconstruction. Our approach is to use a fixed four-camera setup as a front-end system to capture enhanced 3D topography of a pseudo-surgical scene. This experimental setup would provide images for the reconstruction algorithms and generation of multiple observing stereo perspectives. The concept of the designed setup is based on the common main objective (CMO principle of current surgical microscopes. These systems are well established and optically mature. Furthermore, the CMO principle allows a more compact design and a lowered effort in calibration than cameras with separate optics. Behind the CMO four pupils separate the four channels which are recorded by one camera each. The designed system captures an area of approximately 28mm × 28mm with four cameras. Thus, allowing to process images of 6 different stereo perspectives. In order to verify the setup, it is modelled in silico. It can be used in further studies to test algorithms for 3D reconstruction from up to four perspectives and provide information about the impact of additionally recorded perspectives on the enhancement of a reconstruction.

  20. D-optimal experimental designs to test for departure from additivity in a fixed-ratio mixture ray.

    Science.gov (United States)

    Coffey, Todd; Gennings, Chris; Simmons, Jane Ellen; Herr, David W

    2005-12-01

    Traditional factorial designs for evaluating interactions among chemicals in a mixture may be prohibitive when the number of chemicals is large. Using a mixture of chemicals with a fixed ratio (mixture ray) results in an economical design that allows estimation of additivity or nonadditive interaction for a mixture of interest. This methodology is extended easily to a mixture with a large number of chemicals. Optimal experimental conditions can be chosen that result in increased power to detect departures from additivity. Although these designs are used widely for linear models, optimal designs for nonlinear threshold models are less well known. In the present work, the use of D-optimal designs is demonstrated for nonlinear threshold models applied to a fixed-ratio mixture ray. For a fixed sample size, this design criterion selects the experimental doses and number of subjects per dose level that result in minimum variance of the model parameters and thus increased power to detect departures from additivity. An optimal design is illustrated for a 2:1 ratio (chlorpyrifos:carbaryl) mixture experiment. For this example, and in general, the optimal designs for the nonlinear threshold model depend on prior specification of the slope and dose threshold parameters. Use of a D-optimal criterion produces experimental designs with increased power, whereas standard nonoptimal designs with equally spaced dose groups may result in low power if the active range or threshold is missed.