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Sample records for spie the international soc

  1. The first SPIE software Hack Day

    Science.gov (United States)

    Kendrew, S.; Deen, C.; Radziwill, N.; Crawford, S.; Gilbert, J.; Gully-Santiago, M.; Kubánek, P.

    2014-07-01

    We report here on the software Hack Day organised at the 2014 SPIE conference on Astronomical Telescopes and Instrumentation in Montréal. The first ever Hack Day to take place at an SPIE event, the aim of the day was to bring together developers to collaborate on innovative solutions to problems of their choice. Such events have proliferated in the technology community, providing opportunities to showcase, share and learn skills. In academic environments, these events are often also instrumental in building community beyond the limits of national borders, institutions and projects. We show examples of projects the participants worked on, and provide some lessons learned for future events.

  2. News from the Library: Advancing light - SPIE Digital Library accessible to CERN till 31 March 2012

    CERN Multimedia

    CERN Library

    2012-01-01

    SPIE (Society of Photo-Optical Instrumentation Engineers) is a not-for-profit international society which publishes one of the largest collections of applied optics and photonics research papers in the world: the SPIE Digital Library.   This resource includes more than 300,000 technical papers from SPIE journals, e-books and conference proceedings from 1990 to the present. The SPIE Digital Library covers many areas of interest for CERN users, such as astronomy, nanotechnology, sensors, lasers, electro-optics and imaging. The CERN Library has trial access to the complete resource till 31 March 2012, don't hesitate to give it a try! Access to the SPIE Digital Library here. We welcome any comment or question at library.desk@cern.ch.

  3. Bibliographic database of PACS-related articles from the SPIE literature

    Science.gov (United States)

    Shile, Peter E.; Freiermuth, Jennifer

    1996-05-01

    Publications of the International Society of Optical Engineering (SPIE) contain much of the relevant literature on Picture Archiving and Communications Systems (PACS) and related topics. In fact, many PACS-related articles indexed by the National Library of Medicine contain references to articles published by SPIE. Unfortunately, SPIE publications themselves are not indexed by the National Library of Medicine and thus can not be identified through Medline. The lack of a convenient mechanism for searching the SPIE literature is problematic for researchers in medical imaging. With the recent introduction on SPIE's Internet server of their Abstracts Online service and their In-CiteTM title and author searching software, the SPIE literature has become more accessible. However, the searching process is still a cumbersome and time consuming process, and it is not possible to perform key word searches of manuscript abstracts. In this paper we present results of our work on developing a mechanism to more thoroughly search SPIE publications for PACS-related articles.

  4. Architectures, Concepts and Architectures for Service Oriented Computing : proceedings of the 1st International Workshop - ACT4SOC 2007

    NARCIS (Netherlands)

    van Sinderen, Marten J.; Unknown, [Unknown

    2007-01-01

    This volume contains the proceedings of the First International Workshop on Architectures, Concepts and Technologies for Service Oriented Computing (ACT4SOC 2007), held on July 22 in Barcelona, Spain, in conjunction with the Second International Conference on Software and Data Technologies (ICSOFT

  5. Proceedings of SPIE - the International Society for Optical Engineering. Ocean Optics 12 Held in Bergen, Norway on 13-15 June 1994

    Science.gov (United States)

    1994-06-15

    International and Oregon State University Oliverio D. Soares, Centro de Ciencias e Tecnologias Opticas/ Universidade do V-orto (Portugal) J. Ronald V...uncorrected absorption measurements from the spectrophotometer with integrating cavity and the I cm cell (Figure 3d ) is similar to that for the poorer...through mathematical volumetric reconstruction steps. 1 2. 3D RECONSTRUCTION THEORY A three step process model serves as the foundation for the three

  6. Sol-Gel Optics: Proceedings SPIE-The International Society for Optical Engineering Held in San Diego, California on 11-13 July 1990. Volume 1328

    Science.gov (United States)

    1992-03-01

    important for optical devises used in such environment as nuclear power stations and space stations. Fig. 9 shows the y-ray dose dependence of the coupling...Bi 2 0 3 and TiO2-CeO 2 Compositions. Michel A. Aegerter, Eliane R. La Serra University of Sao Paulo, Instituto de Fisica e Quimica de Sao Carlos

  7. Analysis of the internal temperature of the cells in a battery pack during SOC balancing

    Science.gov (United States)

    Mizanur, R.; Rashid, M. M.; Rahman, A.; Zahirul Alam, A. H. M.; Ihsan, S.; Mollik, M. S.

    2017-03-01

    Lithium-ion batteries are more suitable for the application of electric vehicle due to high energy and power density compared to other rechargeable batteries. However, the battery pack temperature has a great impact on the overall performance, cycle life, normal charging-discharging behaviour and even safety. During rapid charge transferring process, the internal temperature may exceed its allowable limit (460C). In this paper, an analysis of internal temperature during charge balancing and discharging conditions is presented. Specific interest is paid to the effects of temperature on the different rate of ambient temperature and discharging current. Matlab/Simulink Li-ion battery model and quasi-resonant converter base balancing system are used to study the temperature effect. Rising internal temperature depends on the rate of balancing current and ambient temperature found in the simulation results.

  8. SPIE Smart Structures Product Implementation Award: a review of the first ten years

    Science.gov (United States)

    Anderson, Eric H.; Sater, Janet M.

    2007-04-01

    The research field of smart materials and structures has been a distinct entity for two decades. Over the past ten years, the SPIE Industrial and Commercial Applications Conference has presented a Smart Structures Product Implementation Award at its annual symposium. This paper revisits the nine winning entries to date (1998-2007) and updates their status. The paper begins with a brief description of the original and current intent of the award and follows with a short overview of the evolution of smart structures, from research to products. The winning teams and their respective products are then described. The current status of the products is discussed based on publicly available information and input from the respective companies. Note however that it is not the purpose of the paper to rank the product winners in terms of success or sales. The paper concludes with an assessment of the larger trends in productization of smart structures technologies. The application "form" for the award as well as the evaluation criteria and suggestions for improving award application packages can be found in the appendix.

  9. Laser Beam Shaping XIII, Proceedings of SPIE Vol. 8490

    CSIR Research Space (South Africa)

    Forbes, A

    2012-09-01

    Full Text Available .1117/12.2013615 Proc. of SPIE Vol. 8490 849001-1 Downloaded From: http://proceedings.spiedigitallibrary.org/ on 10/17/2012 Terms of Use: http://spiedl.org/terms The papers included in this volume were part of the technical conference cited on the cover and title..., Bellingham, Washington 98227-0010 USA Telephone +1 360 676 3290 (Pacific Time)? Fax +1 360 647 1445 SPIE.org Copyright ? 2012, Society of Photo-Optical Instrumentation Engineers. Copying of material in this book for internal or personal use...

  10. Respiratory Syncytial Virus Nonstructural Proteins Upregulate SOCS1 and SOCS3 in the Different Manner from Endogenous IFN Signaling

    Directory of Open Access Journals (Sweden)

    Junwen Zheng

    2015-01-01

    Full Text Available Respiratory syncytial virus (RSV infection upregulates genes of the suppressor of cytokine signaling (SOCS family, which utilize a feedback loop to inhibit type I interferon dependent antiviral signaling pathway. Here, we reconstituted RSV nonstructural (NS protein expression plasmids (pNS1, pNS2, and pNS1/2 and tested whether NS1 or NS2 would trigger SOCS1 and SOCS3 protein expression. These NS proteins inhibited interferon- (IFN- α signaling through a mechanism involving the induction of SOCS1 and SOCS3, which appeared to be different from autocrine IFN dependent. NS1 induced both SOCS1 and SOCS3 upregulation, while NS2 only induced SOCS1 expression. The induced expression of SOCS1 and SOCS3 preceded endogenous IFN-signaling activation and inhibited the IFN-inducible antiviral response as well as chemokine induction. Treatments with INF-α and NS proteins both induced SOCS1 expression; however, they had opposing effects on IFN-α-dependent antiviral gene expression. Our results indicate that NS1 and NS2, which induce the expression of SOCS1 or SOCS3, might represent an independent pathway of stimulating endogenous IFN signaling.

  11. Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing

    Science.gov (United States)

    Feng, Yi; Sanders, Andrew J.; Ruge, Fiona; Morris, Ceri-Ann; Harding, Keith G.; Jiang, Wen G.

    2016-01-01

    Cytokines play important roles in the wound healing process through various signalling pathways. The JAK-STAT pathway is utilised by most cytokines for signal transduction and is regulated by a variety of molecules, including suppressor of cytokine signalling (SOCS) proteins. SOCS are associated with inflammatory diseases and have an impact on cytokines, growth factors and key cell types involved in the wound-healing process. SOCS, a negative regulator of cytokine signalling, may hold the potential to regulate cytokine-induced signalling in the chronic wound-healing process. Wound edge tissues were collected from chronic venous leg ulcer patients and classified as non-healing and healing wounds. The expression pattern of seven SOCSs members, at the transcript and protein level, were examined in these tissues using qPCR and immunohistochemistry. Significantly higher levels of SOCS3 (P=0.0284) and SOCS4 (P=0.0376) in non-healing chronic wounds compared to the healing/healed chronic wounds were observed at the transcript level. Relocalisation of SOCS3 protein in the non-healing wound environment was evident in the investigated chronic biopsies. Thus, the results show that the expression of SOCS transcript indicated that SOCS members may act as a prognostic biomarker of chronic wounds. PMID:27635428

  12. The simple art of SoC design

    CERN Document Server

    Keating, Michael

    2011-01-01

    This book tackles head-on the challenges of digital design in the era of billion-transistor SoCs. It discusses fundamental design concepts in design and coding required to produce robust, functionally correct designs. It also provides specific techniques for measuring and minimizing complexity in RTL code. Finally, it discusses the tradeoff between RTL and high-level (C-based) design and how tools and languages must progress to address the needs of tomorrow's SoC designs.

  13. Spie, mandarini, bramini: i gesuiti e i loro travestimenti / Spies, Mandarins, Brahmins. The Jesuits and their disguises

    Directory of Open Access Journals (Sweden)

    Sabina Pavone

    2013-05-01

    Full Text Available Nella prima età moderna l’abito degli ordini religiosi rappresenta un importante fattore di identità immediatamente riconoscibile. È per questo motivo che i gesuiti vennero visti con sospetto: essi erano infatti vestiti come preti secolari. Ignazio di Loyola decise di non avere alcun segno distintivo poiché voleva vivere nel mondo, ma la sua scelta venne male interpretata e intesa come una forma di dissimulazione: la mancanza di un abito specifico fu vista come strumentale all’assunzione di ogni tipo di travestimento e presto, in determinati contesti, i gesuiti vennero considerati vere e proprie spie. Ai loro occhi infatti indossare l’abito del paese che si accingevano a evangelizzare era anche il modo migliore, certo non l’unico, per entrare in contatto con le altre culture. In questo saggio si vuole prendere in esame tanto l’uso dell’abito come elemento della pratica evangelizzatrice nelle missioni quanto la leggenda nera che dalle origini circondò i gesuiti e vide proprio nell’abito uno dei segni più importanti della loro attitudine al travestimento.   In the early modern age, the religious orders habit represent a very significant factor of identity to be immediately recognised, that’s why the Jesuits were looked with suspicion: in fact they were dressed as secular priests. Ignazio of Loyola decided not to have any distinctive sign because he wanted to live inside the world, but this choice was misinterpreted as a way of dissimulation: the lack of an habit was considered as a manner to assume any kind of disguise and soon Jesuits were considered as spies. In their opinion, to take the habit of the country they wanted to evangelize, was also the best way to be brought into contact with others cultures. In this paper I would like to consider either the Jesuits evangelisation practice in missions or the black legend that since the origins surrounded them considering also the habit one of the most important signal of their

  14. EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA

    Directory of Open Access Journals (Sweden)

    V. V. Lim

    2014-01-01

    Full Text Available We observed sixty patients with allergic bronchial asthma (ABA and 54 with non-allergic bronchial asthma (NABA. Quantitative SOCS3 and SOCS5 mRNA expression was evaluated by means of real-time PCR. Eighteen healthy persons served as a control group. In patients with bronchial asthma (irrespectively of pathogenetic form, a significant increase of SOCS3 transcription factor expression was detected in peripheral blood mononuclears, as compared with control group. This increase was more pronounced in NABA group. The mRNA SOCS5 level was significantly decreased in bronchial asthma patients, as compared to control group, especially, in ABA subgroup rather than in NABA patients. Thus, an increased expression of SOCS3 mRNA in BA patients could be regarded as a protective antiinflammatory response Decrease of SOCS5 mRNA expression in patients with bronchial asthma (being more pronounced in ABA, may be indicative for a deficiency in negative feedback regulation of gene transcription in allergic bronchial asthma.

  15. SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.

    Science.gov (United States)

    Vuong, Bao Q; Arenzana, Teresita L; Showalter, Brian M; Losman, Julie; Chen, X Peter; Mostecki, Justin; Banks, Alexander S; Limnander, Andre; Fernandez, Neil; Rothman, Paul B

    2004-10-01

    The regulation of cytokine signaling is critical for controlling cellular proliferation and activation during an immune response. SOCS-1 is a potent inhibitor of Jak kinase activity and of signaling initiated by several cytokines. SOCS-1 protein levels are tightly regulated, and recent data suggest that SOCS-1 may regulate the protein levels of some signaling proteins by the ubiquitin proteasome pathway; however, the cellular mechanism by which SOCS-1 directs proteins for degradation is unknown. In this report, SOCS-1 is found to colocalize and biochemically copurify with the microtubule organizing complex (MTOC) and its associated 20S proteasome. The SOCS-1 SH2 domain is required for the localization of SOCS-1 to the MTOC. Overexpression of SOCS-1 targets Jak1 in an SH2-dependent manner to a perinuclear distribution resembling the MTOC-associated 20S proteasome. Analysis of MTOCs fractionated from SOCS-1-deficient cells demonstrates that SOCS-1 may function redundantly to regulate the localization of Jak1 to the MTOC. Nocodazole inhibits the protein turnover of SOCS-1, demonstrating that the minus-end transport of SOCS-1 to the MTOC-associated 20S proteasome is required to regulate SOCS-1 protein levels. These data link SOCS-1 directly with the proteasome pathway and suggest another function for the SH2 domain of SOCS-1 in the regulation of Jak/STAT signaling.

  16. A Generalized SOC-OCV Model for Lithium-Ion Batteries and the SOC Estimation for LNMCO Battery

    Directory of Open Access Journals (Sweden)

    Caiping Zhang

    2016-11-01

    Full Text Available A state-of-charge (SOC versus open-circuit-voltage (OCV model developed for batteries should preferably be simple, especially for real-time SOC estimation. It should also be capable of representing different types of lithium-ion batteries (LIBs, regardless of temperature change and battery degradation. It must therefore be generic, robust and adaptive, in addition to being accurate. These challenges have now been addressed by proposing a generalized SOC-OCV model for representing a few most widely used LIBs. The model is developed from analyzing electrochemical processes of the LIBs, before arriving at the sum of a logarithmic, a linear and an exponential function with six parameters. Values for these parameters are determined by a nonlinear estimation algorithm, which progressively shows that only four parameters need to be updated in real time. The remaining two parameters can be kept constant, regardless of temperature change and aging. Fitting errors demonstrated with different types of LIBs have been found to be within 0.5%. The proposed model is thus accurate, and can be flexibly applied to different LIBs, as verified by hardware-in-the-loop simulation designed for real-time SOC estimation.

  17. SPIE's School Outreach Activity Program (SOAP) by IIT Madras SPIE Student Chapter: a review

    Science.gov (United States)

    Kalikivayi, Lavanya; Kalikivayi, V.; Udayakumar, K.; Ganesan, A. R.

    2014-09-01

    One of the important aspects of SPIE is "Community Support and Outreach Education", which should raise awareness and interest in optics and photonics among the targeted communities and school children. Hence as part of SPIE IIT Madras student chapter, we carried out SPIE SOAP, a `School Outreach Activity Program'. Two types of schools were identified, one a high socio-economic status school and the other a low socio-economic status school having a majority of poor children. Optics related scientific experiments were demonstrated in these schools followed by oral quiz session to the students to assess the level of their knowledge before and after the experiments. We also clubbed this activity with "Vision Screening" and distribution of free spectacles for those children who live below poverty line. Out of the 415 children screened, 60.84% eyes were having normal vision, while 39.16% were found to have refractive errors (Myopia 35.78% and Hyperopia 3.38%) where some of them could not even read the board. Treatable eye diseases were also found in 0.72% of the children. The entire activity is been discussed and documented in this paper.

  18. SOCS-1 Localizes to the Microtubule Organizing Complex-Associated 20S Proteasome

    OpenAIRE

    Vuong, Bao Q.; Arenzana, Teresita L.; Showalter, Brian M.; Losman, Julie; Chen, X. Peter; Mostecki, Justin; Banks, Alexander S.; Limnander, Andre; Fernandes, Neil; Rothman, Paul B.

    2005-01-01

    The regulation of cytokine signaling is critical for controlling cellular proliferation and activation during an immune response. SOCS-1 is a potent inhibitor of Jak kinase activity and of signaling initiated by several cytokines. SOCS-1 protein levels are tightly regulated, and recent data suggest that SOCS-1 may regulate the protein levels of some signaling proteins by the ubiquitin proteasome pathway; however, the cellular mechanism by which SOCS-1 directs proteins for degradation is unkno...

  19. Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells

    International Nuclear Information System (INIS)

    Lesinski, Gregory B; Zimmerer, Jason M; Kreiner, Melanie; Trefry, John; Bill, Matthew A; Young, Gregory S; Becknell, Brian; Carson, William E III

    2010-01-01

    Endogenously produced interferons can regulate the growth of melanoma cells and are administered exogenously as therapeutic agents to patients with advanced cancer. We investigated the role of negative regulators of interferon signaling known as suppressors of cytokine signaling (SOCS) in mediating interferon-resistance in human melanoma cells. Basal and interferon-alpha (IFN-α) or interferon-gamma (IFN-γ)-induced expression of SOCS1 and SOCS3 proteins was evaluated by immunoblot analysis in a panel of n = 10 metastatic human melanoma cell lines, in human embryonic melanocytes (HEM), and radial or vertical growth phase melanoma cells. Over-expression of SOCS1 and SOCS3 proteins in melanoma cells was achieved using the PINCO retroviral vector, while siRNA were used to inhibit SOCS1 and SOCS3 expression. Tyr 701 -phosphorylated STAT1 (P-STAT1) was measured by intracellular flow cytometry and IFN-stimulated gene expression was measured by Real Time PCR. SOCS1 and SOCS3 proteins were expressed at basal levels in melanocytes and in all melanoma cell lines examined. Expression of the SOCS1 and SOCS3 proteins was also enhanced following stimulation of a subset of cell lines with IFN-α or IFN-γ. Over-expression of SOCS proteins in melanoma cell lines led to significant inhibition of Tyr 701 -phosphorylated STAT1 (P-STAT1) and gene expression following stimulation with IFN-α (IFIT2, OAS-1, ISG-15) or IFN-γ (IRF1). Conversely, siRNA inhibition of SOCS1 and SOCS3 expression in melanoma cells enhanced their responsiveness to interferon stimulation. These data demonstrate that SOCS proteins are expressed in human melanoma cell lines and their modulation can influence the responsiveness of melanoma cells to IFN-α and IFN-γ

  20. The Impact of Strong Cathodic Polarization on SOC Electrolyte Materials

    DEFF Research Database (Denmark)

    Kreka, Kosova; Hansen, Karin Vels; Jacobsen, Torben

    2016-01-01

    One of the most promising reversible energy conversion/storage technologies is that of Solid Oxide Fuel/Electrolysis Cells (SOFC/SOEC, collectively termed SOC). Long term durability is typically required for such devises to become economically feasible, hence considerable amount of work has...... of impurities at the grain boundaries, electrode poisoning, delamination or cracks of the electrolyte etc., have been observed in cells operated at such conditions, lowering the lifetime of the cell1,2. High polarizations are observed at the electrolyte/cathode interface of an electrolysis cell operated at high...... current density. In case of a cell voltage above 1.6 V, p-type and n-type electronic conductivity are often observed at the anode and cathode respectively3. Hence, a considerable part of the current is lost as leakage through the electrolyte, thus lowering the efficiency of the cell considerably....

  1. Correlation between the model accuracy and model-based SOC estimation

    International Nuclear Information System (INIS)

    Wang, Qianqian; Wang, Jiao; Zhao, Pengju; Kang, Jianqiang; Yan, Few; Du, Changqing

    2017-01-01

    State-of-charge (SOC) estimation is a core technology for battery management systems. Considerable progress has been achieved in the study of SOC estimation algorithms, especially the algorithm on the basis of Kalman filter to meet the increasing demand of model-based battery management systems. The Kalman filter weakens the influence of white noise and initial error during SOC estimation but cannot eliminate the existing error of the battery model itself. As such, the accuracy of SOC estimation is directly related to the accuracy of the battery model. Thus far, the quantitative relationship between model accuracy and model-based SOC estimation remains unknown. This study summarizes three equivalent circuit lithium-ion battery models, namely, Thevenin, PNGV, and DP models. The model parameters are identified through hybrid pulse power characterization test. The three models are evaluated, and SOC estimation conducted by EKF-Ah method under three operating conditions are quantitatively studied. The regression and correlation of the standard deviation and normalized RMSE are studied and compared between the model error and the SOC estimation error. These parameters exhibit a strong linear relationship. Results indicate that the model accuracy affects the SOC estimation accuracy mainly in two ways: dispersion of the frequency distribution of the error and the overall level of the error. On the basis of the relationship between model error and SOC estimation error, our study provides a strategy for selecting a suitable cell model to meet the requirements of SOC precision using Kalman filter.

  2. Proceedings SPIE: Conference Digest, International Conference on Infrared and Millimeter Waves (18th) Held in Colchester, United Kingdom on 6-10 September 1993. Volume 2104

    Science.gov (United States)

    1993-09-10

    effective dielectric constant appears to decrease upon the substitution of PbO, 1. INRODUCTION In V2 05 - TeO2 glasses several studies on equilibrium... glass increases as TeOg is partially replaced by PbO. Previous studies on V20 5 - TeO2 system 4.5 have reported three Infrared absorption bands at 1010...Laboratory, Dr, K,S. Krishnan Road, New Delhi 110012, India. Th4., REFLECTANCE STUDY OF TM,O. GLASSES - AMemon, M,N.Khan, SAI-Dallal, Department of

  3. What are the effects of agricultural management on soil organic carbon (SOC) stocks?

    DEFF Research Database (Denmark)

    Söderström, Bo; Hedlund, Katarina; Jackson, Louise E.

    2014-01-01

    the physical and biological properties of the soil. Intensification of agriculture and land-use change from grasslands to croplands are generally known to deplete SOC stocks. The depletion is exacerbated through agricultural practices with low return of organic material and various mechanisms......Changes in soil organic carbon (SOC) stocks significantly influence the atmospheric C concentration. Agricultural management practices that increase SOC stocks thus may have profound effects on climate mitigation. Additional benefits include higher soil fertility since increased SOC stocks improve......, such as oxidation/mineralization, leaching and erosion. However, a systematic review comparing the efficacy of different agricultural management practices to increase SOC stocks has not yet been produced. Since there are diverging views on this matter, a systematic review would be timely for framing policies...

  4. The mechanisms behind the formation of a strong Sense of Coherence (SOC): The role of migration and integration

    NARCIS (Netherlands)

    Slootjes, J.; Keuzenkamp, Saskia; Saharso, S.

    2017-01-01

    Considering how much we know about the impact of the Sense of Coherence (SOC) on different health-related outcomes, we know surprisingly little about how a strong SOC actually develops. In this study we examine the mechanisms behind the formation of a strong SOC and study the role of migration,

  5. Low-Power Differential SRAM design for SOC Based on the 25-um Technology

    Science.gov (United States)

    Godugunuri, Sivaprasad; Dara, Naveen; Sambasiva Nayak, R.; Nayeemuddin, Md; Singh, Yadu, Dr.; Veda, R. N. S. Sunil

    2017-08-01

    In recent, the SOC styles area unit the vast complicated styles in VLSI these SOC styles having important low-power operations problems, to comprehend this we tend to enforced low-power SRAM. However these SRAM Architectures critically affects the entire power of SOC and competitive space. To beat the higher than disadvantages, during this paper, a low-power differential SRAM design is planned. The differential SRAM design stores multiple bits within the same cell, operates at minimum in operation low-tension and space per bit. The differential SRAM design designed supported the 25-um technology using Tanner-EDA Tool.

  6. Comparison Study on the Battery SoC Estimation with EKF and UKF Algorithms

    Directory of Open Access Journals (Sweden)

    Hongwen He

    2013-09-01

    Full Text Available The battery state of charge (SoC, whose estimation is one of the basic functions of battery management system (BMS, is a vital input parameter in the energy management and power distribution control of electric vehicles (EVs. In this paper, two methods based on an extended Kalman filter (EKF and unscented Kalman filter (UKF, respectively, are proposed to estimate the SoC of a lithium-ion battery used in EVs. The lithium-ion battery is modeled with the Thevenin model and the model parameters are identified based on experimental data and validated with the Beijing Driving Cycle. Then space equations used for SoC estimation are established. The SoC estimation results with EKF and UKF are compared in aspects of accuracy and convergence. It is concluded that the two algorithms both perform well, while the UKF algorithm is much better with a faster convergence ability and a higher accuracy.

  7. SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer

    DEFF Research Database (Denmark)

    Iglesias Gato, Diego; Chuan, Yin Choy; Wikström, Pernilla

    2014-01-01

    ) as mediator of the cross talk between androgens and GH signals in the prostate and its potential role as tumor suppressor in prostate cancer (PCa). We observed that SOCS2 protein levels assayed by immunohistochemistry are elevated in hormone therapy-naive localized prostatic adenocarcinoma in comparison...... of transcription 5 protein (STAT5) and androgen receptor-dependent transcription. Consequentially, SOCS2 inhibits GH activation of Janus kinase 2, Src and STAT5 as well as both cell invasion and cell proliferation in vitro. In vivo, SOCS2 limits proliferation and production of IGF-1 in the prostate in response......Anabolic signals such as androgens and the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis play an essential role in the normal development of the prostate but also in its malignant transformation. In this study, we investigated the role of suppressor of cytokine signaling 2 (SOCS2...

  8. The impact of soil redistribution on SOC pools in a Mediterranean agroforestry catchment

    Science.gov (United States)

    Quijano, Laura; Gaspar, Leticia; Lizaga, Iván; Navas, Ana

    2017-04-01

    Soil redistribution processes play an important role influencing the spatial distribution patterns of soil and associated soil organic carbon (SOC) at landscape scale. Information on drivers of SOC dynamics is key for evaluating both soil degradation and SOC stability that can affect soil quality and sustainability. 137Cs measurements provide a very effective tool to infer spatial patterns of soil redistribution and quantify soil redistribution rates in different landscapes, but to date these data are scarce in mountain Mediterranean agroecosystems. We evaluate the effect of soil redistribution on SOC and SOC pools in relation to land use in a Mediterranean mountain catchment (246 ha). To this purpose, two hundred and four soil bulk cores were collected on a 100 m grid in the Estaña lakes catchment located in the central sector of the Spanish Pyrenees (31T 4656250N 295152E). The study area is an agroforestry and endorheic catchment characterized by the presence of evaporite dissolution induced dolines, some of which host permanent lakes. The selected landscape is representative of rainfed areas of Mediterranean continental climate with erodible lithology and shallow soils, and characterized by an intense anthropogenic activity through cultivation and water management. The cultivated and uncultivated areas are heterogeneously distributed. SOC and SOC pools (the active and decomposable fraction, ACF and the stable carbon fraction SCF) were measured by the dry combustion method and soil redistribution rates were derived from 137Cs measurements. The results showed that erosion predominated in the catchment, most of soil samples were identified as eroded sites (n=114) with an average erosion rate of 26.9±51.4 Mg ha-1 y-1 whereas the mean deposition rate was 13.0±24.2 Mg ha-1 y-1. In cultivated soils (n=54) the average of soil erosion rate was significantly higher (78.5±74.4 Mg ha-1 y-1) than in uncultivated soils (6.8±10.4 Mg ha-1 y-1). Similarly, the mean of soil

  9. Evaluation of SOC for the presumptive identification of Candida albicans and Cryptococcus neoformans.

    Science.gov (United States)

    Fleming, W H; Knezek, K L; Dorn, G L

    1987-01-01

    SOC, a fungal growth medium composed of Solryth, oxgall, and caffeic acid, was evaluated as a medium to provide rapid, differential identification of Candida albicans and Cryptococcus neoformans. Using a variety of common isolation media to produce the yeast inocula, the germ tube methods tested ranked in the following order of decreasing sensitivity: SOC (97% +/- 1), serum (92% +/- 5), rabbit coagulase plasma with EDTA in combination with tryptic soy broth (89% +/- 5), TOC (89% +/- 6), and rabbit coagulase plasma with EDTA (83% +/- 4). In chlamydospore production, SOC also proved to be the most sensitive after 24 h incubation: SOC (96% +/- 2), TOC (80% +/- 2), and cornmeal-Tween 80 agar (14% +/- 3). Other medically important yeasts showed normal patterns of growth within 24 h on SOC, thus assisting in their identification. Eighty strains of Cryptococcus neoformans showed characteristic brown pigmentation on SOC and TOC within 18 h, while all other species of the genus Cryptococcus and 229 Candida isolates did not show a change in pigmentation.

  10. A Bayesian Belief Network framework to predict SOC stock change: the Veneto region (Italy) case study

    Science.gov (United States)

    Dal Ferro, Nicola; Quinn, Claire Helen; Morari, Francesco

    2017-04-01

    A key challenge for soil scientists is predicting agricultural management scenarios that combine crop productions with high standards of environmental quality. In this context, reversing the soil organic carbon (SOC) decline in croplands is required for maintaining soil fertility and contributing to mitigate GHGs emissions. Bayesian belief networks (BBN) are probabilistic models able to accommodate uncertainty and variability in the predictions of the impacts of management and environmental changes. By linking multiple qualitative and quantitative variables in a cause-and-effect relationships, BBNs can be used as a decision support system at different spatial scales to find best management strategies in the agroecosystems. In this work we built a BBN to model SOC dynamics (0-30 cm layer) in the low-lying plain of Veneto region, north-eastern Italy, and define best practices leading to SOC accumulation and GHGs (CO2-equivalent) emissions reduction. Regional pedo-climatic, land use and management information were combined with experimental and modelled data on soil C dynamics as natural and anthropic key drivers affecting SOC stock change. Moreover, utility nodes were introduced to determine optimal decisions for mitigating GHGs emissions from croplands considering also three different IPCC climate scenarios. The network was finally validated with real field data in terms of SOC stock change. Results showed that the BBN was able to model real SOC stock changes, since validation slightly overestimated SOC reduction (+5%) at the expenses of its accumulation. At regional level, probability distributions showed 50% of SOC loss, while only 17% of accumulation. However, the greatest losses (34%) were associated with low reduction rates (100-500 kg C ha-1 y-1), followed by 33% of stabilized conditions (-100 < SOC < 100 kg ha-1 y-1). Land use management (especially tillage operations and soil cover) played a primary role to affect SOC stock change, while climate conditions

  11. Use of 'sense of coherence (SOC)' scale to measure resilience in Eritrea: interrogating both the data and the scale.

    Science.gov (United States)

    Almedom, Astier M; Tesfamichael, Berhe; Saeed Mohammed, Zein; Mascie-Taylor, C G N; Alemu, Zemui

    2007-01-01

    An adapted 'sense of coherence' scale short form (SOC-13) was administered in nine languages of Eritrea with a total of 265 participants (162 women and 103 men) in order to assess 'resilience' in quantitative terms. Statistical analysis yielded significant differences in SOC scores between the displaced and non-displaced: mean=54.84 (SD=6.48) in internally displaced person (IDP) camps, compared with mean=48.94 (SD=11.99) in urban and rural settlements (t=3.831, purban (non-displaced) residents. Those in rural but traditionally mobile (pastoralist or transhumant) communities scored more or less the same as the urban non-displaced - i.e. significantly higher than those in IDP camps (purban and pastoralist/transhumant groups are similar, while women in IDP camps are lower scoring (RR=0.268, p<0.001), Hamboka women being worst affected due to their experience of serial displacement. These findings are interpreted and discussed in the light of qualitative information gleaned from the study participants' interrogation of the content of the SOC scale; and in the wider context of historical, socio-political and cultural characteristics of Eritrea. The study's implications for humanitarian and public health policy are considered.

  12. Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis.

    Directory of Open Access Journals (Sweden)

    Marc Amoyel

    2016-01-01

    Full Text Available The Drosophila testis is a well-established system for studying stem cell self-renewal and competition. In this tissue, the niche supports two stem cell populations, germ line stem cells (GSCs, which give rise to sperm, and somatic stem cells called cyst stem cells (CySCs, which support GSCs and their descendants. It has been established that CySCs compete with each other and with GSCs for niche access, and mutations have been identified that confer increased competitiveness to CySCs, resulting in the mutant stem cell and its descendants outcompeting wild type resident stem cells. Socs36E, which encodes a negative feedback inhibitor of the JAK/STAT pathway, was the first identified regulator of niche competition. The competitive behavior of Socs36E mutant CySCs was attributed to increased JAK/STAT signaling. Here we show that competitive behavior of Socs36E mutant CySCs is due in large part to unbridled Mitogen-Activated Protein Kinase (MAPK signaling. In Socs36E mutant clones, MAPK activity is elevated. Furthermore, we find that clonal upregulation of MAPK in CySCs leads to their outcompetition of wild type CySCs and of GSCs, recapitulating the Socs36E mutant phenotype. Indeed, when MAPK activity is removed from Socs36E mutant clones, they lose their competitiveness but maintain self-renewal, presumably due to increased JAK/STAT signaling in these cells. Consistently, loss of JAK/STAT activity in Socs36E mutant clones severely impairs their self-renewal. Thus, our results enable the genetic separation of two essential processes that occur in stem cells. While some niche signals specify the intrinsic property of self-renewal, which is absolutely required in all stem cells for niche residence, additional signals control the ability of stem cells to compete with their neighbors. Socs36E is node through which these processes are linked, demonstrating that negative feedback inhibition integrates multiple aspects of stem cell behavior.

  13. E-CMIRC - towards a model for the integration of services between SOCs and CSIRTs

    CSIR Research Space (South Africa)

    Jacobs, P

    2015-07-01

    Full Text Available , including governments. While the focus of a SOC is on the monitoring of technical security controls and critical assets, and the response to attacks and threats, CSIRTs’ main focus is on response and incident management. One postulation is that a CSIRT...

  14. Neighborhood-resources for the development of a strong SOC and the importance of understanding why and how resources work: a grounded theory approach.

    Science.gov (United States)

    Maass, Ruca; Lindström, Bengt; Lillefjell, Monica

    2017-09-12

    Providing individuals with psychosocial resources such as sense of coherence (SOC) seems a beneficial strategy for health promotion in the neighborhood. In order to become a supporting theory for health promotion, Salutogenesis should renew its focus on resources for health, and explore how the development of a strong SOC can be facilitated. Relevant issues were explored using a Grounded Theory- approach. Three focus-group-sessions and three in-depth interviews were conducted with strategically sampled participants. The transcripts of the focus groups were initially analyzed line-by-line to ensure that insights emerged from the data. We then applied focused and systemic analyses to achieve axial coding, and to include insights into how social interactions during focus groups may reveal social processes in real-life-neighborhoods. The data from the in-depth interviews were used to validate and fill emerging categories, as well as to ensure data-saturation. Findings indicate the importance of repeated experiences with resources and every-day-challenges to develop a strong SOC. Active engagement with resources is a favorable condition for significant experiences, which enhance the internalization of resources. Core experiences are characterized by a re-organization of resources. Participation in intellectual meaning-making through equal power dialogue seems to broaden perspectives and promote the strengthening of SOC. A strong SOC can also be described as a deeper understanding of how and why resources work, which allows for a more flexible use of resources, including replacing missing resources. A new understanding of SOC as an intuitive understanding of how, why and under which circumstances resources work, as well as a new focus on everyday life and repeated experiences might facilitate new approaches to a purposeful strengthening of SOC through the planning and implementation of public measures.

  15. Community Readiness Within Systems of Care: The Validity and Reliability of the System of Care Readiness and Implementation Measurement Scale (SOC-RIMS).

    Science.gov (United States)

    Rosas, Scott R; Behar, Lenore B; Hydaker, William M

    2016-01-01

    Establishing a system of care requires communities to identify ways to successfully implement strategies and support positive outcomes for children and their families. Such community transformation is complex and communities vary in terms of their readiness for implementing sustainable community interventions. Assessing community readiness and guiding implementation, specifically for the funded communities implementing a system of care, requires a well-designed tool with sound psychometric properties. This scale development study used the results of a previously published concept mapping study to create, administer, and assess the psychometric characteristics of the System of Care Readiness and Implementation Measurement Scale (SOC-RIMS). The results indicate the SOC-RIMS possesses excellent internal consistency characteristics, measures clearly discernible dimensions of community readiness, and demonstrates the target constructs exist within a broad network of content. The SOC-RIMS can be a useful part of a comprehensive assessment in communities where system of care practices, principles, and philosophies are implemented and evaluated.

  16. The Immunohistochemical Analysis of SOCS3 Protein Identifies a Subgroup of Prostatic Cancer Biopsies With Aggressive Behavior.

    Science.gov (United States)

    Pierconti, Francesco; Martini, Maurizio; Cenci, Tonia; Larocca, Luigi M

    Recently, we demonstrated that hypermethylation of SOCS3 determines a significant reduction of its mRNA and protein expression and identifies a subgroup of prostate cancer with aggressive behavior. In this paper, our objective was to investigate whether the immunohistochemical expression of the SOCS3 protein could represent an alternative method to molecular analysis for the individualization of aggressive prostate carcinoma. We analyzed the SOCS3 immunohistochemical expression in 65 patients undergoing biopsies at the Institute of Urology of our hospital between September 2011 and October 2011 (median age, 66.4 y; range, 50 to 73 y), and in 35 cases, a subset of 65 cases originally used for the immunohistochemical study, we studied the methylation status of the SOCS3 promoter. We found that the percentage of cases with SOCS3 negativity (-) or with SOCS3 weak staining in <50% of the neoplastic glands (+/-) correlated to the worst prognosis in terms of the Gleason score (P=0.0001; Fisher's exact test), the pT stage (P=0.012; Fisher's exact test), and progression-free survival (P=0.0334; hazard ratio, 0.34; and 95% confidence interval, from 0.1261 to 0.9188). Moreover, some cases with an SOCS3 unmethylated pattern showed SOCS3-negative immunostaining (-) or SOCS3-negative glands with weak cytoplasmatic staining in <50% of the neoplastic glands (+/-). Our data suggest that in prostatic cancer biopsies, the immunohistochemical analysis of SOCS3 protein expression may provide a method that is less expensive and easier to apply than SOCS3 methylation analysis for the distinction of a subgroup of prostate cancer with a more aggressive behavior.

  17. The ComSoc guide to managing telecommunications projects

    CERN Document Server

    Desmond, Celia

    2010-01-01

    "This pocket guide provides an overview of the telecommunications environment as it has evolved over the past few years, illustrating the need for project management, the significance of project success to the companies, and the application of key project management processes within the telecom environment. Topics covered include: scope management, time management, cost management, procurement management, risk management, communications, quality, human resources, and Integration. It offers professionals a brief and accessible guide to managing telecommunication projects in the 21st century"--

  18. Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase

    DEFF Research Database (Denmark)

    Zadjali, Fahad; Pike, Ashley C W; Vesterlund, Mattias

    2011-01-01

    to substrate residue position pY+6 and envelopes the c-KIT phosphopeptide with a large BG loop insertion that contributes significantly to substrate interaction. We demonstrate that SOCS6 has ubiquitin ligase activity toward c-KIT and regulates c-KIT protein turnover in cells. Our data support a role of SOCS6...

  19. The fate of SOC during the processes of water erosion and subsequent deposition: a field study.

    Science.gov (United States)

    van Hemelryck, H.; Govers, G.; van Oost, K.; Merckx, R.

    2009-04-01

    Globally soils are the largest terrestrial pool of carbon (C). A relatively small increase or decrease in soil carbon content due to changes in land use or management practices could therefore result in a significant net exchange of C between the soil C reservoir and the atmosphere. As such, the geomorphic processes of water and tillage erosion have been identified to significantly impact on this large pool of soil organic carbon (SOC). Soil erosion, transport and deposition not only result in redistribution of sediments and associated carbon within a landscape, but also affect the exchange of C between the pedosphere and the atmosphere. The direction and magnitude of an erosion-induced change in the global C balance is however a topic of much debate as opposing processes interact: i) At eroding sites a net uptake of C could be the result of reduced respiration rates and continued inputs of newly produced carbon. ii) Colluvial deposition of eroded sediment and SOC leads to the burial of the original topsoil and this may constrain the decomposition of its containing SOC. iii) Eroded sediment could be transported to distal depositional environments or fluvial systems where it will either be conserved or become rapidly mineralized. iv) Increased emission of CO2 due to erosion may result from the disruptive energy of erosive forces causing the breakdown of aggregates and exposing previously protected SOC to microbial decomposition. The above-mentioned processes show a large spatial and temporal variability and assessing their impact requires an integrated modeling approach. However uncertainties about the basic processes that accompany SOC displacement are still large. This study focuses on one of these large information gaps: the fate of eroded and subsequently deposited SOC. A preceding experimental study (Van Hemelryck et al., 2008) was used to identify controlling factors (erosional intensity, changes in soil structure,…). However this experimental research

  20. Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells.

    Science.gov (United States)

    Xiong, Hua; Du, Wan; Zhang, Yan-Jie; Hong, Jie; Su, Wen-Yu; Tang, Jie-Ting; Wang, Ying-Chao; Lu, Rong; Fang, Jing-Yuan

    2012-02-01

    Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2-containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulators of JAK/STAT signaling, have been reported to have tumor suppressor functions. However, in colorectal cancer (CRC) cells, the mechanisms that regulate SOCS and SHP1 genes, and the cause of abnormalities in the JAK/STAT signaling pathway, remain largely unknown. The present study shows that trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, leads to the hyperacetylation of histones associated with the SOCS1 and SOCS3 promoters, but not the SHP1 promoter in CRC cells. This indicates that histone modifications are involved in the regulation of SOCS1 and SOCS3. Moreover, upregulation of SOCS1 and SOCS3 expression was achieved using TSA, which also significantly downregulated JAK2/STAT3 signaling in CRC cells. We also demonstrate that TSA suppresses the growth of CRC cells, and induces G1 cell cycle arrest and apoptosis through the regulation of downstream targets of JAK2/STAT3 signaling, including Bcl-2, survivin and p16(ink4a) . Therefore, our data demonstrate that TSA may induce SOCS1 and SOCS3 expression by inducing histone modifications and consequently inhibits JAK2/STAT3 signaling in CRC cells. These results also establish a mechanistic link between the inhibition of JAK2/STAT3 signaling and the anticancer action of TSA in CRC cells. Copyright © 2011 Wiley Periodicals, Inc.

  1. Digital approach for the design of statistical analog data acquisition on SoCs

    OpenAIRE

    Adao Antonio de Souza Junior

    2005-01-01

    With the current demand for mixed-signal SoCs, an increasing number of designers are looking for ADC architectures that can be easily implemented over digital substrates. Since ADC performance is strongly dependent upon physical and electrical features, it gets more difficult for them to benefit from more recent technologies, where these features are more variable. This way, analog signal acquisition is not allowed to follow an evolutionary trend compatible with Moore’s Law. In fact, such tre...

  2. Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm.

    Science.gov (United States)

    Zhang, Min Yue; Fung, Tsz Kin; Chen, Fang Yuan; Chim, Chor Sang

    2013-10-01

    Janus kinase-signal transducer and activator of transcription (JAK/STAT) signalling, pivotal in Philadelphia-negative (Ph-ve) myeloproliferative neoplasm (MPN), is negatively regulated by molecules including SOCSs, CISH and SHP1. SOCS1, SOCS2 and SOCS3 methylation have been studied in MPN with discordant results. Herein, we studied the methylation status of SOCS1, SOCS2 and SOCS3, CISH and SHP1 by methylation-specific polymerase chain reaction (MSP) in cell lines and 45 diagnostic marrow samples of Ph-ve MPN. Moreover, we attempted to explain the discordance of methylation frequency by mapping the studied MSP primers to the respective genes. Methylation was detected in normal controls using SOCS2 MSP primers in the 3'translated exonic sequence, but not primers around the transcription start site in the 5' untranslated regions (5'UTR). SOCS1, SOCS2, SOCS3 and CISH were completely unmethylated in primary MPN samples and cell lines. In contrast, methylation of SHP1 was detected in 8.9% primary marrow samples. Moreover, SHP1 was completely methylated in K562 cell line, leading to reversible SHP1 silencing. A review of methylation studies of SOCS1 and SOCS3 showed that spuriously high rates of SOCS methylation had been reported using MSP primers targeting CpG sites in the 3'translated exonic sequence, which is also methylated in normal controls. However, using MSP primers localized to the 5'UTR, methylation of SOCS1, SOCS2 and SOCS3 is infrequent across all studies. In summary, methylation of SOCS1, SOCS2, SOCS3 and CISH is infrequent in Ph-ve MPN. Appropriate MSP primers are important for accurate estimation of the methylation frequency. The role of SHP1 methylation in the pathogenesis of MPN warrants further investigation. © 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  3. Measurement of the complete core plasma flow across the LOC-SOC transition at ASDEX Upgrade

    Science.gov (United States)

    Lebschy, A.; McDermott, R. M.; Angioni, C.; Geiger, B.; Prisiazhniuk, D.; Cavedon, M.; Conway, G. D.; Dux, R.; Dunne, M. G.; Kappatou, A.; Pütterich, T.; Stroth, U.; Viezzer, E.; the ASDEX Upgrade Team

    2018-02-01

    A newly installed core charge exchange recombination spectroscopy (CXRS) diagnostic at ASDEX Upgrade (AUG) enables the evaluation of the core poloidal rotation (upol ) through the inboard-outboard asymmetry of the toroidal rotation with an accuracy of 0.5 to 1 km s-1 . Using this technique, the total plasma flow has been measured in Ohmic L-mode plasmas across the transition from the linear to saturated ohmic confinement (LOC-SOC) regimes. The core poloidal rotation of the plasma around mid-radius is found to be always in the ion diamagnetic direction, in disagreement with neoclassical (NC) predictions. The edge rotation is found to be electron-directed and consistent with NC codes. This measurement provides as well the missing ingredient to evaluate the core E×B velocity (uE×B ) from data only, which can then be compared to measurements of the perpendicular velocity of the turbulent fluctuations (u\\perp ) to gain information on the turbulent phase velocity (vph ). The non neoclassical upol from CXRS leads to good agreement between uE×B and u\\perp indicating that vph is small and at similar values as found with gyrokinetic simulations. Moreover, the data shows a shift of vph in the ion-diamagnetic direction at the edge after the transition from LOC to SOC consistent with a change in the dominant turbulence regime. The upgrade of the core CXRS system provides as well a deeper insight into the intrinsic rotation. This paper shows that the reversal of the core toroidal rotation occurs clearly after the LOC-SOC transition and concomitant with the peaking of the electron density.

  4. Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1.

    Science.gov (United States)

    Dobie, Ross; Ahmed, Syed F; Staines, Katherine A; Pass, Chloe; Jasim, Seema; MacRae, Vicky E; Farquharson, Colin

    2015-11-01

    Growth hormone (GH) signaling is essential for postnatal linear bone growth, but the relative importance of GHs actions on the liver and/or growth plate cartilage remains unclear. The importance of liver derived insulin like-growth factor-1 (IGF-1) for endochondral growth has recently been challenged. Here, we investigate linear growth in Suppressor of Cytokine Signaling-2 (SOCS2) knockout mice, which have enhanced growth despite normal systemic GH/IGF-1 levels. Wild-type embryonic ex vivo metatarsals failed to exhibit increased linear growth in response to GH, but displayed increased Socs2 transcript levels (P growth over a 12 day period. Despite this increase, IGF-1 transcript and protein levels were not increased in response to GH. In accordance with these data, IGF-1 levels were unchanged in GH-challenged postnatal Socs2(-/-) conditioned medium despite metatarsals showing enhanced linear growth. Growth-plate Igf1 mRNA levels were not elevated in juvenile Socs2(-/-) mice. GH did however elevate IGF-binding protein 3 levels in conditioned medium from GH challenged metatarsals and this was more apparent in Socs2(-/-) metatarsals. GH did not enhance the growth of Socs2(-/-) metatarsals when the IGF receptor was inhibited, suggesting that IGF receptor mediated mechanisms are required. IGF-2 may be responsible as IGF-2 promoted metatarsal growth and Igf2 expression was elevated in Socs2(-/-) (but not WT) metatarsals in response to GH. These studies emphasise the critical importance of SOCS2 in regulating GHs ability to promote bone growth. Also, GH appears to act directly on the metatarsals of Socs2(-/-) mice, promoting growth via a mechanism that is independent of IGF-1. © 2014 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

  5. IGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus).

    Science.gov (United States)

    Liu, Cai-Zhi; Luo, Yuan; Limbu, Samwel Mchele; Chen, Li-Qiao; Du, Zhen-Yu

    2018-05-20

    Insulin-like growth factor-1 (IGF-1) plays a crucial role in regulating growth in vertebrates whereas suppressors of cytokine signaling (SOCS) act as feedback inhibitors of the GH/IGF-1 axis. Although SOCS-2 binds the IGF-1 receptor and inhibits IGF-1-induced STAT3 activation, presently there is no clear evidence as to whether IGF-1 could induce SOCS gene expression. The current study aimed to determine whether IGF-1 could induce the transcription of SOCS in juvenile Nile tilapia ( Oreochromis niloticus ). We show that there is a common positive relationship between the mRNA expression of IGF-I and SOCS-2 under different nutritional statuses and stimulants, but not the mRNA expression of SOCS-1 and SOCS-3 Furthermore, rhIGF-1 treatment and transcriptional activity assay confirmed the hypothesis that IGF-1 could induce SOCS-2 expression, whereas it had no effect or even decreased the expression of SOCS-1 and SOCS-3 Overall, we obtained evidence that the transcription of SOCS-2, but not SOCS-1 or SOCS-3, could be induced by IGF signaling, suggesting that SOCS-2 serves as a feedback suppressor of the IGF-1 axis in juvenile Nile tilapia. © 2018. Published by The Company of Biologists Ltd.

  6. Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus.

    Science.gov (United States)

    Strebovsky, Julia; Walker, Patrick; Lang, Roland; Dalpke, Alexander H

    2011-03-01

    Suppressor of cytokine signaling (SOCS) proteins are inhibitors of cytoplasmic Janus kinases (Jak) and signal transducer and activator of transcription (STAT) signaling pathways. Previously the authors surprisingly observed that SOCS1 translocated into the nucleus, which was because of the presence of a nuclear localization sequence. This report now hypothesizes that SOCS1 mediates specific functions within the nuclear compartment because it is instantly transported into the nucleus, as shown by photoactivation and live cell imaging in human HEK293 cells. The NFκB component p65 is identified as an interaction partner for SOCS1 but not for other members of the SOCS family. SOCS1 bound to p65 only within the nucleus. By means of its SOCS box domain, SOCS1 operated as a ubiquitin ligase, leading to polyubiquitination and proteasomal degradation of nuclear p65. Thus, SOCS1 limited prolonged p65 signaling and terminated expression of NFκB inducible genes. Using mutants that lack either nuclear translocation or a functional SOCS box, this report identifies genes that are regulated in a manner dependent on the nuclear availability of SOCS1. Data show that beyond its receptor-proximal function in Jak/STAT signaling, SOCS1 also regulates the duration of NFκB signaling within the cell nucleus, thus exerting a heretofore unrecognized function.

  7. SOC Strategies and Organizational Citizenship Behaviors toward the Benefits of Co-workers: A Multi-Source Study

    Science.gov (United States)

    Müller, Andreas; Weigl, Matthias

    2017-01-01

    Background: Individuals’ behavioral strategies like selection, optimization, and compensation (SOC) contribute to efficient use of available resources. In the work context, previous studies revealed positive associations between employees’ SOC use and favorable individual outcomes, like engagement and job performance. However, the social implications of self-directed behaviors like SOC that are favorable for the employee but may imply consequences for coworkers have not been investigated yet in an interpersonal work context. Objective: This study aimed to assess associations between employees’ use of SOC behaviors at work and their organizational citizenship behaviors (OCB) toward the benefits of co-workers rated by their peers at work. We further sought to identify age-specific associations between SOC use and OCB. Design and Method: A cross-sectional design combining multi-source data was applied in primary school teachers (age range: 23–58 years) who frequently teach in dyads. N = 114 dyads were finally included. Teachers reported on their SOC strategies at work. Their peer colleagues evaluated teachers’ OCB. Control variables were gender, workload, working hours, and perceived proximity of relationship between the dyads. Results: We observed a positive effect of loss-based selection behaviors on peer-rated OCB. Moreover, there was a significant two-way interaction effect between the use of compensation strategies and age on OCB, such that there was a positive association for older employees and a negative association for younger employees. There were no significant main and age-related interaction effects of elective selection, optimization, and of overall SOC strategies on OCB. Conclusion: Our study suggests that high use of loss-based selection and high use of compensation strategies in older employees is positively related with OCB as perceived by their colleagues. However, high use of compensation strategies in younger employees is perceived

  8. SOC Strategies and Organizational Citizenship Behaviors toward the Benefits of Co-workers: A Multi-Source Study.

    Science.gov (United States)

    Müller, Andreas; Weigl, Matthias

    2017-01-01

    Background: Individuals' behavioral strategies like selection, optimization, and compensation (SOC) contribute to efficient use of available resources. In the work context, previous studies revealed positive associations between employees' SOC use and favorable individual outcomes, like engagement and job performance. However, the social implications of self-directed behaviors like SOC that are favorable for the employee but may imply consequences for coworkers have not been investigated yet in an interpersonal work context. Objective: This study aimed to assess associations between employees' use of SOC behaviors at work and their organizational citizenship behaviors (OCB) toward the benefits of co-workers rated by their peers at work. We further sought to identify age-specific associations between SOC use and OCB. Design and Method: A cross-sectional design combining multi-source data was applied in primary school teachers (age range: 23-58 years) who frequently teach in dyads. N = 114 dyads were finally included. Teachers reported on their SOC strategies at work. Their peer colleagues evaluated teachers' OCB. Control variables were gender, workload, working hours, and perceived proximity of relationship between the dyads. Results: We observed a positive effect of loss-based selection behaviors on peer-rated OCB. Moreover, there was a significant two-way interaction effect between the use of compensation strategies and age on OCB, such that there was a positive association for older employees and a negative association for younger employees. There were no significant main and age-related interaction effects of elective selection, optimization, and of overall SOC strategies on OCB. Conclusion: Our study suggests that high use of loss-based selection and high use of compensation strategies in older employees is positively related with OCB as perceived by their colleagues. However, high use of compensation strategies in younger employees is perceived negatively

  9. Constitutive expression of the K-domain of a Vaccinium corymbosum SOC1-like (VcSOC1-K) MADS-box gene is sufficient to promote flowering in tobacco.

    Science.gov (United States)

    Song, Guo-qing; Walworth, Aaron; Zhao, Dongyan; Hildebrandt, Britton; Leasia, Michael

    2013-11-01

    The K-domain of a blueberry-derived SOC1 -like gene promotes flowering in tobacco without negatively impacting yield, demonstrating potential for manipulation of flowering time in horticultural crops. The SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) and SOC1-likes, belonging to the MIKC(c) (type II) MADS-box gene subfamily, are major floral activators and integrators of plant flowering. Both MADS-domains and K (Keratin)-domains are highly conserved in MIKC(c)-type MADS proteins. While there are many reports on overexpression of intact MIKC(c)-type MADS-box genes, few studies have been conducted to investigate the effects of the K-domains. In this report, a 474-bp K-domain of Vaccinium SOC1-like (VcSOC1-K) was cloned from the cDNA library of the northern highbush blueberry (Vaccinium corymbosum L.). Functional analysis of the VcSOC1-K was conducted by ectopically expressing of 35S:VcSOC1-K in tobacco. Reverse transcription PCR confirmed expression of the VcSOC1-K in T0 plants. Phenotypically, T1 transgenic plants (10 T1 plants/event) flowered sooner after seeding, and were shorter with fewer leaves at the time of flowering, than nontransgenic plants; but seed pod production of transgenic plants was not significantly affected. These results demonstrate that overexpression of the K-domain of a MIKC(c)-type MADS-box gene alone is sufficient to promote early flowering and more importantly without affecting seed production.

  10. Proceedings of the ADPA/AIAA/ASME/SPIE Conference on Active and Adaptive Structures Held in Alexandria, Virginia on November 4 - 8, 1991

    Science.gov (United States)

    1991-11-08

    We have been using CV to investigate the effects of redox compounds, inciluding proteins of various types, and of drugs on BLMs. Recent results...bonds Aith bridging diarylphosphates. The resultant cocrystal takes up a ribbon structure with the pyrTidinium-phosphate hydrogen bond network at its core...and vice-versa. Ideally, to obtain F.D.A. (Federal Drug Administration) approval, the smaller the current, the better. This meant the Nitinol

  11. ETHERBONE - a network layer for the wishbone SoC bus

    International Nuclear Information System (INIS)

    Kreider, M.; Terpstra, W.; Lewis, J.; Serrano, J.; Wlostowski, T.

    2012-01-01

    Today, there are several System on a Chip (SoC) bus systems. Typically, these buses are confined on-chip and rely on higher level components to communicate with the outside world. Taking these systems a step further, we see the possibility of extending the reach of the SoC bus to remote FPGAs or processors. This leads to the idea of the EtherBone (EB) core, which connects a Wishbone (WB) Ver. 4 Bus via a Gigabit Ethernet based network link to remote peripheral devices. EB acts as a transparent interconnect module towards attached WB Bus devices. Address information and data from one or more WB bus cycles is preceded with a descriptive header and encapsulated in a UDP/IP packet. Because of this standard compliance, EB is able to traverse Wide Area Networks and is therefore not bound to a geographic location. Due to the low level nature of the WB bus, EB provides a sound basis for remote hardware tools like a JTAG debugger, In-System-Programmer (ISP), boundary scan interface or logic analyser module. EB was developed in the scope of the White-Rabbit Timing Project (WR) at CERN and GSI/FAIR, which employs GigaBit Ethernet technology to communicate with memory mapped slave devices. WR will make use of EB as means to issue commands to its timing nodes and control connected accelerator hardware. (authors)

  12. EtherBone - A Network Layer for the Wishbone SoC Bus

    CERN Document Server

    Kreider, M; Lewis, J; Włostowski, T; Serrano, J

    2011-01-01

    Today, there are several System on a Chip (SoC) bus systems. Typically, these buses are confined on-chip and rely on higher level components to communicate with the outside world. Taking these systems a step further, we see the possibility of extending the reach of the SoC bus to remote FPGAs or processors. This leads to the idea of the EtherBone (EB) core, which connects a Wishbone (WB) Ver. 4 Bus via a Gigabit Ethernet based network link to remote peripheral devices. EB acts as a transparent interconnect module towards attached WB Bus devices. Address information and data from one or more WB bus cycles is preceded with a descriptive header and encapsulated in a UDP/IP packet. Because of this standard compliance, EB is able to traverse Wide Area Networks and is therefore not bound to a geographic location. Due to the low level nature of the WB bus, EB provides a sound basis for remote hardware tools like a JTAG debugger, In-System-Programmer (ISP), boundary scan interface or logic analyser module. EB was de...

  13. Suppressor of Cytokine Signaling (SOCS 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

    Directory of Open Access Journals (Sweden)

    Edmond M Linossi

    Full Text Available Suppressor of Cytokine Signaling (SOCS5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is unclear. We show for the first time that SOCS5 can interact directly with JAK via a unique, conserved region in its N-terminus, which we have termed the JAK interaction region (JIR. Co-expression of SOCS5 was able to specifically reduce JAK1 and JAK2 (but not JAK3 or TYK2 autophosphorylation and this function required both the conserved JIR and additional sequences within the long SOCS5 N-terminal region. We further demonstrate that SOCS5 can directly inhibit JAK1 kinase activity, although its mechanism of action appears distinct from that of SOCS1 and SOCS3. In addition, we identify phosphoTyr317 in Shc-1 as a high-affinity substrate for the SOCS5-SH2 domain and suggest that SOCS5 may negatively regulate EGF and growth factor-driven Shc-1 signaling by binding to this site. These findings suggest that different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling.

  14. SOCS3 inhibits the pathological effects of IL-22 in non-melanoma skin tumor-derived keratinocytes.

    Science.gov (United States)

    Madonna, Stefania; Scarponi, Claudia; Morelli, Martina; Sestito, Rosanna; Scognamiglio, Pasqualina Liana; Marasco, Daniela; Albanesi, Cristina

    2017-04-11

    Basal cell carcinomas (BCC) and squamous-cell carcinomas (SCC) are common malignancies in humans, caused by neoplastic transformation of keratinocytes of the basal or suprabasal layers of epidermis, respectively. Tumor-infiltrating lymphocytes (TILs) are frequently found in BCC and SCC, and functionally promote epithelial carcinogenesis. TILs secreting IL-22, in particular, participate to BCC and SCC growth by inducing keratinocyte proliferation and migration, as well as the expression of inflammatory, anti-apoptotic and pro-angiogenic genes.In this study, we identified SOCS3 as a valid candidate to be manipulated for suppressing tumorigenic functions in BCC and SCC. We found that SOCS3 and SOCS1 expression was reduced in vivo, in tumor lesions of BCC and SCC, as compared to other skin inflammatory conditions such as psoriasis, despite the high number of IL-22-secreting TILs. Moreover, IL-22 was not able to induce in vitro the transcriptional expression of SOCS3 in BCC-or SCC-derived keratinocytes, contrarily to healthy cells. Aimed at rescuing SOCS3 activity in these tumor contexts, a SOCS3-derived peptide, named KIR-ESS, was synthesized, and its ability in suppressing IL-22-induced responses was evaluated in healthy and transformed keratinocytes. We found that KIR-ESS peptide efficiently suppressed the IL-22 molecular signaling in keratinocytes, by acting on STAT3 and Erk1/2 cascade, as well as on the expression of STAT3-dependent downstream genes. Interestingly, after treatment with peptide, both healthy and transformed keratinocytes could no longer aberrantly proliferate and migrate in response to IL-22. Finally, treatment of athymic nude mice bearing SCC xenografts with KIR-ESS peptide concomitantly reduced tumor growth and activated STAT3 levels. As a whole, these data provides the rationale for the use in BCC and SCC skin tumors of SOCS3 mimetics, being able to inhibit the deleterious effects of IL-22 in these contexts.

  15. Improved OCV Model of a Li-Ion NMC Battery for Online SOC Estimation Using the Extended Kalman Filter

    Directory of Open Access Journals (Sweden)

    Ines Baccouche

    2017-05-01

    Full Text Available Accurate modeling of the nonlinear relationship between the open circuit voltage (OCV and the state of charge (SOC is required for adaptive SOC estimation during the lithium-ion (Li-ion battery operation. Online SOC estimation should meet several constraints, such as the computational cost, the number of parameters, as well as the accuracy of the model. In this paper, these challenges are considered by proposing an improved simplified and accurate OCV model of a nickel manganese cobalt (NMC Li-ion battery, based on an empirical analytical characterization approach. In fact, composed of double exponential and simple quadratic functions containing only five parameters, the proposed model accurately follows the experimental curve with a minor fitting error of 1 mV. The model is also valid at a wide temperature range and takes into account the voltage hysteresis of the OCV. Using this model in SOC estimation by the extended Kalman filter (EKF contributes to minimizing the execution time and to reducing the SOC estimation error to only 3% compared to other existing models where the estimation error is about 5%. Experiments are also performed to prove that the proposed OCV model incorporated in the EKF estimator exhibits good reliability and precision under various loading profiles and temperatures.

  16. Intense microwave pulses II. SPIE Volume 2154

    International Nuclear Information System (INIS)

    Brandt, H.E.

    1994-01-01

    The primary purpose of this conference was to present and critically evaluate new and ongoing research on the generation and transmission of intense microwave pulses. Significant progress was reported on high-power, high-current relativistic klystron amplifier research and design. Other work presented at the conference, include research on a high-power relativistic magnetron driven by a high-current linear induction accelerator, derivation of a Pierce-type dispersion relation describing the interaction of an intense relativistic electron beam with a corrugated cylindrical slow-wave structure, experiments on an X-band backward-wave cyclotron maser oscillator, and observation of frequency chirping in a free electron laser amplifier. Other presentations included work on multiwave Cerenkov generator experiments, analysis of resonance characteristics of slow-wave structures in high-power Cerenkov devices, linear analysis and numerical simulation of Doppler-shifted cyclotron harmonics in a cyclotron autoresonance klystron, high-power virtual cathode oscillator theory and experiments, design of a sixth-harmonic gyrofrequency multiplier as a millimeter-wave source, and experiments on dielectric-loaded and multiwave slotted gyro-TWT amplifiers. A review was presented on innovative concepts which employ high-power microwaves in propulsion of space vehicles. Separate abstracts were prepared for 34 papers of this conference

  17. William L. Wolfe, 1989 President of SPIE, encourages scientists from Eastern Europe

    Science.gov (United States)

    Schmit, Joanna

    2012-10-01

    In 1990 Professor Wolfe after his SPIE presidency trekked the world, even making it as far as post-communist Poland, to see (in the visible and maybe in infrared - who knows) the work of optical scientists hidden behind the iron curtain. I am not sure if he was ready for how different that world was at this time, but for sure he was very inquisitive and eager to learn about the nuances of Poland right after the fall of communism. He met, visited with and encouraged young and old scientists from Poland, Russia, Hungary and Lithuania to add their expertise to the scientific conversations happening in the West. His mission in Poland was to invite us all, and he was ready to help us achieve our dreams. I was one of those he encouraged. This talk is my personal reflection of Professor Wolfe as an encouraging and sometimes brave SPIE pioneer - a stranger in a strange land - and as an energetic, caring SPIE president, Optical Sciences professor and human being. Disclaimer: Professor Bill Wolfe's contributions to the field of radiometry are well known and very well recognized. This conference is a tribute to him. However, my paper is not on radiometry; rather, I wish to illustrate the adventurous, caring and positive Bill Wolfe that helped me find my way to the American desert Southwest.

  18. [Characteristics of Soil Respiration along Eroded Sloping Land with Different SOC Background on the Hilly Loess Plateau].

    Science.gov (United States)

    Chen, Gai; Xu, Ming-xiang; Zhang, Ya-feng; Wang, Chao-hua; Fan, Hui-min; Wang, Shan-shan

    2015-09-01

    This study aimed to characterize soil respiration along eroded sloping land at erosion and deposition area under different soil organic carbon(SOC) levels, and linked the relationship between soil respiration and soil temperature, soil moisture, SOC and slope position. Experiments were carried out in the plots of S type slopes include five different soil organic carbon levels in the Loess Hilly Region. The S type slopes were divided into control area at the top of the slope, erosion area at the middle of the slope and deposition area at the toe of the slope. We found that soil temperature had a greater impact on soil respiration in the deposition area, whereas soil moisture had a greater impact on soil respiration in the erosion area compared among control area, erosion area and deposition area. In addition, SOC was the most important factor affecting soil respiration, which can explain soil respiration variation 54. 72%, followed by soil moisture, slope position and soil temperature, which explain soil respiration variation 18. 86% , 16. 13% and 10. 29%, respectively. Soil respiration response to erosion showed obvious on-site and off-site effects along the eroded sloping land. Soil respiration in the erosion area was reduced by 21. 14% compared with control area, and soil respiration in the deposition area was increased by 21. 93% compared with control area. Erosion effect on source and sink of carbon emission was correlated with SOC content of the eroded sloping land. When SOC content was higher than 6. 82 g.kg-1, the slope. erosion tended to be a carbon sequestration process, and when SOC content was lower than 3.03 g.kg-1, the slope erosion tended to be a process of the carbon emission source. The model could reflect the relationship between soil respiration and independent variables of soil organic carbon content, soil temperature and moisture.

  19. SOC Strategies and Organizational Citizenship Behaviors toward the Benefits of Co-workers: A Multi-Source Study

    Directory of Open Access Journals (Sweden)

    Andreas Müller

    2017-10-01

    Full Text Available Background: Individuals’ behavioral strategies like selection, optimization, and compensation (SOC contribute to efficient use of available resources. In the work context, previous studies revealed positive associations between employees’ SOC use and favorable individual outcomes, like engagement and job performance. However, the social implications of self-directed behaviors like SOC that are favorable for the employee but may imply consequences for coworkers have not been investigated yet in an interpersonal work context.Objective: This study aimed to assess associations between employees’ use of SOC behaviors at work and their organizational citizenship behaviors (OCB toward the benefits of co-workers rated by their peers at work. We further sought to identify age-specific associations between SOC use and OCB.Design and Method: A cross-sectional design combining multi-source data was applied in primary school teachers (age range: 23–58 years who frequently teach in dyads. N = 114 dyads were finally included. Teachers reported on their SOC strategies at work. Their peer colleagues evaluated teachers’ OCB. Control variables were gender, workload, working hours, and perceived proximity of relationship between the dyads.Results: We observed a positive effect of loss-based selection behaviors on peer-rated OCB. Moreover, there was a significant two-way interaction effect between the use of compensation strategies and age on OCB, such that there was a positive association for older employees and a negative association for younger employees. There were no significant main and age-related interaction effects of elective selection, optimization, and of overall SOC strategies on OCB.Conclusion: Our study suggests that high use of loss-based selection and high use of compensation strategies in older employees is positively related with OCB as perceived by their colleagues. However, high use of compensation strategies in younger employees is

  20. SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes

    Directory of Open Access Journals (Sweden)

    Thais T. Zampieri

    2015-03-01

    Conclusions: Our study identified the increased hypothalamic expression of SOCS3 as a key mechanism responsible for triggering pregnancy-induced leptin resistance and metabolic adaptations. These findings not only help to explain a common phenomenon of the mammalian physiology, but it may also aid in the development of approaches to prevent and treat gestational metabolic imbalances.

  1. An OCP Compliant Network Adapter for GALS-based SoC Design Using the MANGO Network-on-Chip

    DEFF Research Database (Denmark)

    Bjerregaard, Tobias; Mahadevan, Shankar; Olsen, Rasmus Grøndahl

    2005-01-01

    decouples communication and computation, providing memory-mapped OCP transactions based on primitive message-passing services of the network. Also, it facilitates GALS-type systems, by adapting to the clockless network. This helps leverage a modular SoC design flow. We evaluate performance and cost of 0...

  2. Land use changing SOC pool: A field investigation from four catchments on the Loess Plateau in China

    Science.gov (United States)

    Guo, Shengli; Wang, Rui; Hu, Yaxian

    2017-04-01

    The Loess Plateau in China has long been known for severe erosion, a degraded ecosystem and heavy sediment delivery to the Yellow River. Apart from, the highly erodible loess soil and the hilly geomorphology, intensive cultivation has been caused such most destructive human activities. This made the Loess Plateau once the least fertile region in China with extreme poverty. To restore soil fertility and ecosystem sustainability, a national-level project was launched in 1990s to encourage land use changes via afforestation or conversion of cropland back to grassland or woodland. After nearly three decades of land use conversion, the SOC pool in the soil can be expected to have substantially changed. However, climate conditions, geomorphic types and soil properties were spatially distinctive across the Loess Plateau. Their individual as well interactive impacts on changes of soil carbon pool during land use conversions must thus be properly accounted for. In this study, four watersheds distributed over the Loess Plateau were investigated. The four watersheds mainly consisted of three geomorphic types: wide gully, loess ridge, and round knoll. On each geomorphic feature, three land use types prevailed: cropland, grassland and woodland. In total, 695 soil samples were taken from the top 20 cm of the four watersheds during 2010 and 2011. Our results show: 1) Degrees of erosion hugely differed among the four watersheds, with Catchment A (hilly) having three times more erosion modulus than the least eroded Catchment D (gully) (12000 vs. 1800 Mg per km2 per year). 2) The increasing SOC content from 4 mg g-1 at Catchment A to 8.1 mg g-1 at Catchment D agreed well with their decreasing erosion, suggesting that geomorphology induced erosion history was the predominant factor to set the general level of watershed-scale SOC reservoir. 3) Within each watershed, grassland and woodland consistently had at least 34% more SOC than cropland, demonstrating the influence of land use

  3. Gaining Insights on the H2–Sorbent Interactions: Robust soc-MOF Platform as a Case Study

    KAUST Repository

    Cairns, Amy

    2016-09-18

    We report on the synthesis and gas adsorption properties (i.e., Ar and H2) of four robust 3-periodic metal–organic frameworks (MOFs) having the targeted soc topology. These cationic MOFs are isostructural to the parent indium-based MOF, In-soc-MOF-1a (for NO3–), previously reported by us, and likewise are constructed from the assembly of rigid μ3-oxygen-centered trinuclear metal carboxylate clusters, [M3O(O2C−)6], where M = In3+ or Fe3+. Each inorganic trinuclear molecular building block (MBB), generated in situ, is bridged by six 3,3′,5,5′-azobenzenetetracarboxylate (ABTC4–) ligands to give the extended (4,6)-connected MOF, soc-MOF. In our previous work, we confirmed that the parent soc-MOF, i.e., In-soc-MOF-1a, possesses unique structural characteristics (e.g., vacant In binding sites and narrow pores with higher localized charge density), which led to exceptional hydrogen (H2) storage capabilities. Therefore, charged MOFs with soc topology can be viewed collectively as an ideal prototypical platform to examine the impact of specific structural parameters on H2–MOF interactions via systematic gas adsorption studies. We infer that enhanced binding of molecular H2 is primarily governed by the presence and type of vacant metal centers (i.e., Fe was shown to exhibit stronger H2–MOF interactions at low H2 loading compared to the In analogues). These findings are evident from the associated isosteric heat of adsorption (Qst) at low loadings and inelastic neutron scattering (INS) experiments of the rotational transitions of sorbed H2, as well as, temperature-programmed desorption (TPD) studies (for a select compound). The importance of localized charge density is also highlighted, where the extra-framework nitrate anions in the Fe-soc-MOF-1a (for NO3–) facilitate enhanced binding affinities as compared to the chloride analogue.

  4. Overexpression of DOSOC1, an ortholog of Arabidopsis SOC1, promotes flowering in the orchid Dendrobium Chao Parya Smile.

    Science.gov (United States)

    Ding, Lihua; Wang, Yanwen; Yu, Hao

    2013-04-01

    SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1) encodes a MADS-box protein that plays an essential role in integrating multiple flowering signals to regulate the transition from vegetative to reproductive development in the model plant Arabidopsis. Although SOC1-like genes have been isolated in various angiosperms, its orthologs in Orchidaceae, one of the largest families of flowering plants, are so far unknown. To investigate the regulatory mechanisms of flowering time control in orchids, we isolated a SOC1-like gene, DOSOC1, from Dendrobium Chao Praya Smile. DOSOC1 was highly expressed in reproductive organs, including inflorescence apices, pedicels, floral buds and open flowers. Its expression significantly increased in whole plantlets during the transition from vegetative to reproductive development, which usually occurred after 8 weeks of culture in Dendrobium Chao Praya Smile. In the shoot apex at the floral transitional stage, DOSOC1 was particularly expressed in emerging floral meristems. Overexpression of DOSOC1 in wild-type Arabidopsis plants resulted in early flowering, which was coupled with the up-regulation of two other flowering promoters, AGAMOUS-LIKE 24 and LEAFY. In addition, overexpression of DOSOC1 was able partially to complement the late-flowering phenotype of Arabidopsis soc1-2 loss-of-function mutants. Furthermore, we successfully created seven 35S:DOSOC1 transgenic Dendrobium orchid lines, which consistently exhibited earlier flowering than wild-type orchids. Our results suggest that SOC1-like genes play an evolutionarily conserved role in promoting flowering in the Orchidaceae family, and that DOSOC1 isolated from Dendrobium Chao Praya Smile could serve as an important target for genetic manipulation of flowering time in orchids.

  5. NTP Radioisotopes SOC Ltd

    International Nuclear Information System (INIS)

    Letule, T.

    2017-01-01

    NTP Radioisotopes SOC Ltd, a wholly owned subsidiary of the South African Nuclear Energy Corporation (NECSA). Supplies around 20% of the world's medical radioisotopes used. NTP is a pioneer in the introduction and growth of nuclear medicine as in South Africa. Nuclear medicine is the medical specialty that involves the use of radioactive isotopes in the diagnosis and treatment of diseases. Nuclear medicine contributes to enhancing the lives of the society. There is a compelling need for nuclear medicine to be promoted and utilized in the rest of Africa, due to the increasing prevalence of cancer. Cancer is rapidly becoming a public health crisis in low-income and middle-income countries. In sub-Saharan Africa, patients often present with advanced disease

  6. Plant growth controls short-term changes in soil organic carbon (SOC) stocks of croplands - new insights from the CarboZALF experiment

    Science.gov (United States)

    Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Joana; Albiac Borraz, Elisa; Schmidt, Marten; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

    2016-04-01

    The long-term influence of crop rotations, climate conditions or soil type on soil organic carbon stock (SOC) patterns and gaseous C emissions of agricultural landscapes is widely recognized. However, the question of short-term seasonal changes in SOC within these areas remains unclear. A main reason for this is the detection problem of temporal and spatial variability in gaseous C exchange and thus, changes in SOC stocks (ΔSOC) in a high resolution. This study introduces dynamic C balances as a method to obtain seasonal changes in SOC stocks. Dynamic C balances were calculated by a combination of automatic chamber CO2 exchange measurements and empirical biomass models. Measurements were performed for three consecutive years at a colluvial depression (Colluvic Regosol) in the hummocky ground moraine landscape of NE Germany (CarboZALF experimental site). The investigated crop rotation was maize, winter fodder rye, maize, winter fodder rye, and sudangrass. The site is characterized by a gradient in ground water level (GWL) and related spatial heterogeneity in soil properties, such as SOC as well as soil nitrogen (Nt) stocks. Modelled dynamic C balances reveal that up to 79% of the standard deviation of estimated annual ΔSOC between single chambers emerged during the main period of crop growth (three months in summer). No significant changes in ΔSOC were detected outside the growing season. Instead, differences between chambers remain constant despite ΔSOC dynamics. Environmental variables (Nt stocks of Ap horizon and GWL), affecting plant-mediated C sequestration, explained up to 95% of temporal and spatial variability in CO2 exchange and ΔSOC. Thus, plant activities were the major catalyst for small scale differences in annual ΔSOC of croplands.

  7. Modeling of SOC-700 Hyperspectral Imagery with the CAMEO-SIM Code

    Science.gov (United States)

    2007-10-26

    Yannick, 2001, “SOC-700 and HS-Analysis 2 User’s Manual”, Surface Optics, San Diego [2] Cohen, Michael F. and Wallace, John R., 1993, “ Radiosity ...and Realistic Image Synthesis”, Academic Press, San Francisco [3] Sillion, Francois X. and Puech, Claude, 1994, “ Radiosity and Global Illumination

  8. EVERYTHING MOVES NOTHING STANDS STILL. SOME ASPECTS ABOUT THE MEGASYSTEM EARTH ECO-SOC-ECO

    Directory of Open Access Journals (Sweden)

    Negucioiu Aurel

    2012-12-01

    Full Text Available One of the most important moments of the start or restart of the academic activity has always been the opening of courses in each subject (discipline that would be studied. On these occasions each professor shows to the students the subject of the discipline, place and role that intellectual seizure of that object in the formation of their professional competence required by the exigencies of the time. Most teachers stop on the most important sources, sources of knowledge that young learners can turn to and would be better to turn. They indicate written sources, books, magazines and other publications available in classical libraries and add, especially now, the world’s largest library: the Internet. However, teachers advise students to seek permanently another source, a "book" - permanently opened, the book of reality that contains the most truth and what is very important - many problems waiting to be discovered and resolved. Leafing over "the first pages" of one of the "volumes" of this huge established "book", I found that the paradigm "Everything moves. Nothing stands still" as the paradigm "movement is absolute, and the repose - roughly" is far from having exhausted full knowledge of "everything". But knowledge can enrich through investigation of the unknown aspects. Substantially reducing the size of the unknown we have subscribed to communicate, stopping on several sides and objectives of the issues: Further examination of the main contents of the concept of development; Nominate a limited number of forms of movement in the "kingdom" of the Megasystem Eco-soc-eco; Further investigation of the causes of motion; Pace to and rhythm in which the different forms of movement develop; Which are the directions in which evolve different directions of movement forms.

  9. Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase

    DEFF Research Database (Denmark)

    Andresen, Christina Aaen; Smedegaard, Stine; Sylvestersen, Kathrine Beck

    2014-01-01

    The Ankyrin and SOCS (Suppressor of Cytokine Signaling) box (ASB) family of proteins function as the substrate recognition subunit in a subset of Elongin-Cullin-SOCS (ECS) E3 ubiquitin ligases. Despite counting with 18 members in humans, the identity of the physiological targets of the Asb protei...

  10. Comments on "Precise model measurements versus theoretical prediction of barrier insertion loss in presence of the ground" [J. Acoust. Soc. Am. 73, 44–54 (1983)

    DEFF Research Database (Denmark)

    Rasmussen, Karsten Bo

    1983-01-01

    Some of the theoretical curves in the article by J. Nicolas et al. [J. Acoust. soc. Am. 73, 44–54 (1983)] appear to be erroneous.......Some of the theoretical curves in the article by J. Nicolas et al. [J. Acoust. soc. Am. 73, 44–54 (1983)] appear to be erroneous....

  11. LCM-seq reveals the crucial role of LsSOC1 in heat-promoted bolting of lettuce (Lactuca sativa L.).

    Science.gov (United States)

    Chen, Zijing; Zhao, Wensheng; Ge, Danfeng; Han, Yingyan; Ning, Kang; Luo, Chen; Wang, Shenglin; Liu, Renyi; Zhang, Xiaolan; Wang, Qian

    2018-05-17

    Lettuce (Lactuca sativa L.) is one of the most economically important vegetables. The floral transition in lettuce is accelerated under high temperatures, which can significantly decrease yields. However, the molecular mechanism underlying the floral tranition in lettuce is poorly known. Using laser capture microdissection coupled with RNA sequencing, we isolated shoot apical meristem cells from the bolting-sensitive lettuce line S39 at four critical stages of development. Subsequently, we screened specifically for the flowering-related gene LsSOC1 during the floral transition through comparative transcriptomic analysis. Molecular biology, developmental biology, and biochemical tools were combined to investigate the biological function of LsSOC1 in lettuce. LsSOC1 knockdown by RNA interference resulted in a significant delay in the timing of bolting and insensitivity to high temperature, which indicated that LsSOC1 functions as an activator during heat-promoted bolting in lettuce. We determined that two heat-shock transcription factors, HsfA1e and HsfA4c, bound to the promoter of LsSOC1 to confirm that LsSOC1 played an important role in heat-promoted bolting. This study indicates that LsSOC1 plays a crucial role in the heat-promoted bolting process in lettuce. Further investigation of LsSOC1 may be useful for clarification of the bolting mechanism in lettuce. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  12. Molecular Cloning, Characterization, and Expression of MiSOC1: A Homolog of the Flowering Gene SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 from Mango (Mangifera indica L)

    Science.gov (United States)

    Wei, Junya; Liu, Debing; Liu, Guoyin; Tang, Jie; Chen, Yeyuan

    2016-01-01

    MADS-box transcription factor plays a crucial role in plant development, especially controlling the formation and development of floral organs. Mango (Mangifera indica L) is an economically important fruit crop, but its molecular control of flowering is largely unknown. To better understand the molecular basis of flowering regulation in mango, we isolated and characterized the MiSOC1, a putative mango orthologs for the Arabidopsis SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1/AGAMOUS-LIKE 20 (SOC1/AGL20) with homology-based cloning and RACE. The full-length cDNA (GenBank accession No.: KP404094) is 945 bp in length including a 74 bp long 5′ UTR and a 189 bp long 3′ UTR and the open reading frame was 733 bps, encoding 223 amino acids with molecular weight 25.6 kD. Both sequence alignment and phylogenetic analysis all indicated that deduced protein contained a conservative MADS-box and semi-conservative K domain and belonged to the SOC1/TM3 subfamily of the MADS-box family. Quantitative real-time PCR was performed to investigate the expression profiles of MiSOC1 gene in different tissues/organs including root, stem, leaves, flower bud, and flower. The result indicated MiSOC1 was widely expressed at different levels in both vegetative and reproductive tissues/organs with the highest expression level in the stems’ leaves and inflorescences, low expression in roots and flowers. The expression of MiSOC1 in different flower developmental stages was different while same tissue –specific pattern among different varieties. In addition, MiSOC1 gene expression was affect by ethephon while high concentration ethephon inhibit the expression of MiSOC1. Overexpression of MiSOC1 resulted in early flowering in Arabidopsis. In conclusion, these results suggest that MiSOC1 may act as induce flower function in mango. PMID:27965680

  13. Molecular Cloning, Characterization, and Expression of MiSOC1: A Homolog of the Flowering Gene SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 from Mango (Mangifera indica L).

    Science.gov (United States)

    Wei, Junya; Liu, Debing; Liu, Guoyin; Tang, Jie; Chen, Yeyuan

    2016-01-01

    MADS-box transcription factor plays a crucial role in plant development, especially controlling the formation and development of floral organs. Mango ( Mangifera indica L) is an economically important fruit crop, but its molecular control of flowering is largely unknown. To better understand the molecular basis of flowering regulation in mango, we isolated and characterized the MiSOC1, a putative mango orthologs for the Arabidopsis SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1/AGAMOUS-LIKE 20 (SOC1/AGL20) with homology-based cloning and RACE. The full-length cDNA (GenBank accession No.: KP404094) is 945 bp in length including a 74 bp long 5' UTR and a 189 bp long 3' UTR and the open reading frame was 733 bps, encoding 223 amino acids with molecular weight 25.6 kD. Both sequence alignment and phylogenetic analysis all indicated that deduced protein contained a conservative MADS-box and semi-conservative K domain and belonged to the SOC1/TM3 subfamily of the MADS-box family. Quantitative real-time PCR was performed to investigate the expression profiles of MiSOC1 gene in different tissues/organs including root, stem, leaves, flower bud, and flower. The result indicated MiSOC1 was widely expressed at different levels in both vegetative and reproductive tissues/organs with the highest expression level in the stems' leaves and inflorescences, low expression in roots and flowers. The expression of MiSOC1 in different flower developmental stages was different while same tissue -specific pattern among different varieties. In addition, MiSOC1 gene expression was affect by ethephon while high concentration ethephon inhibit the expression of MiSOC1. Overexpression of MiSOC1 resulted in early flowering in Arabidopsis . In conclusion, these results suggest that MiSOC1 may act as induce flower function in mango.

  14. Assessment of LabSOCS as a tool for the calculation of self-attenuation coefficients in gamma spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, J.; De Medeiros, M. P.; Garcez, R.; Filgueiras, R.; Thalhofer, J.; Da Silva, A. X. [Universidade Federal do Rio de Janeiro, Programa de Engenharia Nuclear, Av. Horacio Macedo 2030, 21945-970 Rio de Janeiro (Brazil); Freitas R, W., E-mail: marqueslopez@yahoo.com.br [Instituto Militar de Engenharia, Secao de Engenharia Nuclear, Praca Gen. Tiburcio 80, 22290-270 Urca, Rio de Janeiro (Brazil)

    2017-10-15

    In spectrometry, the self-attenuation coefficients are fundamental to correct the efficiency of the detection of samples whose density is different from the radioactive standard. To facilitate the procedure of coefficient calculation, mathematical simulations have been widespread as a tool. In this paper, LabSOCS was used to calculate the self-attenuation coefficients for some geometries and the values found were compared to those obtained with MCNPX and experimental values. The percentage deviations found for the self-attenuation coefficient calculated by LabSOCS were below 1.6%, when compared to experimental values. In the extrapolation zone of the fitting curve of the experimental model, the deviations were below 1.9%. The results obtained show that the deviations increase proportionally to the amplitude between the density values of the radioactive standard and the sample. High percentage deviations were also obtained in simulations whose samples had high densities, complex geometries and low energy levels. However, the results indicate that LabSOCS is a tool which may be used in the calculation of self-attenuation coefficients. (Author)

  15. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

    DEFF Research Database (Denmark)

    Adams, T E; Hansen, J A; Starr, R

    1998-01-01

    Four members (SOCS-1, SOCS-2, SOCS-3, and CIS) of a family of cytokine-inducible, negative regulators of cytokine receptor signaling have recently been identified. To address whether any of these genes are induced in response to growth hormone (GH), serum-starved 3T3-F442A fibroblasts were incuba...

  16. MOF Crystal Chemistry Paving the Way to Gas Storage Needs: Aluminum Based soc-MOF for CH4, O2 and CO2 Storage

    KAUST Repository

    Alezi, Dalal

    2015-09-28

    The molecular building block approach was employed effectively to construct a series of novel isoreticular, highly porous and stable, aluminum based Metal-Organic Frameworks with soc topology. From this platform, three compounds were experimentally isolated and fully characterized, namely, the parent Al-soc-MOF-1 and its naphthalene and anthracene analogues. Al-soc-MOF-1 exhibits outstanding gravimetric methane uptake (total and working capacity). It is shown experimentally, for the first time, that the Al-soc-MOF platform can address the challenging Department of Energy dual target of 0.5 g/g (gravimetric) and 264 cm3 (STP)/cm3 (volumetric) methane storage. Furthermore, Al-soc-MOF exhibited the highest total gravimetric and volumetric uptake for carbon dioxide and the utmost total and deliverable uptake for oxygen at relatively high pressures among all microporous MOFs. In order to correlate the MOF pore structure and functionality to the gas storage properties, to better understand the structure-properties relationship, we performed a molecular simulation study and evaluated the methane storage performance of Al-soc-MOF platform using diverse organic linkers. It was found that shortening the parent Al-soc-MOF-1 linker resulted in a noticeable enhancement in the working volumetric capacity at specific temperatures and pressures with amply conserved gravimetric uptake/working capacity. In contrast, further expansion of the organic linker (branches and/or core) led to isostructural Al-soc-MOFs with enhanced gravimetric uptake but noticeably lower volumetric capacity. The collective experimental and simulation studies indicated that the parent Al-soc-MOF-1 exhibits the best compromise between the volumetric and gravimetric total and working uptakes in a wide range of pressure and temperature conditions.

  17. MOF Crystal Chemistry Paving the Way to Gas Storage Needs: Aluminum Based soc-MOF for CH4, O2 and CO2 Storage

    KAUST Repository

    Alezi, Dalal; Belmabkhout, Youssef; Suetin, Mikhail; Bhatt, Prashant; Weselinski, Lukasz Jan; Solovyeva, Vera; Adil, Karim; Spanopoulos, Ioannis; Trikalitis, Pantelis N.; Emwas, Abdul-Hamid M.; Eddaoudi, Mohamed

    2015-01-01

    The molecular building block approach was employed effectively to construct a series of novel isoreticular, highly porous and stable, aluminum based Metal-Organic Frameworks with soc topology. From this platform, three compounds were experimentally isolated and fully characterized, namely, the parent Al-soc-MOF-1 and its naphthalene and anthracene analogues. Al-soc-MOF-1 exhibits outstanding gravimetric methane uptake (total and working capacity). It is shown experimentally, for the first time, that the Al-soc-MOF platform can address the challenging Department of Energy dual target of 0.5 g/g (gravimetric) and 264 cm3 (STP)/cm3 (volumetric) methane storage. Furthermore, Al-soc-MOF exhibited the highest total gravimetric and volumetric uptake for carbon dioxide and the utmost total and deliverable uptake for oxygen at relatively high pressures among all microporous MOFs. In order to correlate the MOF pore structure and functionality to the gas storage properties, to better understand the structure-properties relationship, we performed a molecular simulation study and evaluated the methane storage performance of Al-soc-MOF platform using diverse organic linkers. It was found that shortening the parent Al-soc-MOF-1 linker resulted in a noticeable enhancement in the working volumetric capacity at specific temperatures and pressures with amply conserved gravimetric uptake/working capacity. In contrast, further expansion of the organic linker (branches and/or core) led to isostructural Al-soc-MOFs with enhanced gravimetric uptake but noticeably lower volumetric capacity. The collective experimental and simulation studies indicated that the parent Al-soc-MOF-1 exhibits the best compromise between the volumetric and gravimetric total and working uptakes in a wide range of pressure and temperature conditions.

  18. SOCS proteins in development and disease

    Science.gov (United States)

    Trengove, Monique C; Ward, Alister C

    2013-01-01

    Cytokine and growth factor signaling mediates essential roles in the differentiation, proliferation, survival and function of a number of cell lineages. This is achieved via specific receptors located on the surface of target cells, with ligand binding activating key intracellular signal transduction cascades to mediate the requisite cellular outcome. Effective resolution of receptor signaling is also essential, with excessive signaling having the potential for pathological consequences. The Suppressor of cytokine signaling (SOCS) family of proteins represent one important mechanism to extinguish cytokine and growth factor receptor signaling. There are 8 SOCS proteins in mammals; SOCS1-7 and the alternatively named Cytokine-inducible SH2-containing protein (CISH). SOCS1-3 and CISH are predominantly associated with the regulation of cytokine receptor signaling, while SOCS4-7 are more commonly involved in the control of Receptor tyrosine kinase (RTK) signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. As a consequence of their regulatory properties, SOCS proteins have important functions in development and homeostasis, with increasing recognition of their role in disease, particularly their tumor suppressor and anti-inflammatory functions. This review provides a synthesis of our current understanding of the SOCS family, with an emphasis on their immune and hematopoietic roles. PMID:23885323

  19. Interleaved Subtask Scheduling on Multi Processor SOC

    NARCIS (Netherlands)

    Zhe, M.

    2006-01-01

    The ever-progressing semiconductor processing technique has integrated more and more embedded processors on a single system-on-achip (SoC). With such powerful SoC platforms, and also due to the stringent time-to-market deadlines, many functionalities which used to be implemented in ASICs are

  20. Rock-Eval analysis of French forest soils: the influence of depth, soil and vegetation types on SOC thermal stability and bulk chemistry

    Science.gov (United States)

    Soucemarianadin, Laure; Cécillon, Lauric; Baudin, François; Cecchini, Sébastien; Chenu, Claire; Mériguet, Jacques; Nicolas, Manuel; Savignac, Florence; Barré, Pierre

    2017-04-01

    Soil organic matter (SOM) is the largest terrestrial carbon pool and SOM degradation has multiple consequences on key ecosystem properties like nutrients cycling, soil emissions of greenhouse gases or carbon sequestration potential. With the strong feedbacks between SOM and climate change, it becomes particularly urgent to develop reliable routine methodologies capable of indicating the turnover time of soil organic carbon (SOC) stocks. Thermal analyses have been used to characterize SOM and among them, Rock-Eval 6 (RE6) analysis of soil has shown promising results in the determination of in-situ SOC biogeochemical stability. This technique combines a phase of pyrolysis followed by a phase of oxidation to provide information on both the SOC bulk chemistry and thermal stability. We analyzed with RE6 a set of 495 soils samples from 102 permanent forest sites of the French national network for the long-term monitoring of forest ecosystems (''RENECOFOR'' network). Along with covering pedoclimatic variability at a national level, these samples include a range of 5 depths up to 1 meter (0-10 cm, 10-20 cm, 20-40 cm, 40-80 cm and 80-100 cm). Using RE6 parameters that were previously shown to be correlated to short-term (hydrogen index, HI; T50 CH pyrolysis) or long-term (T50 CO2 oxidation and HI) SOC persistence, and that characterize SOM bulk chemical composition (oxygen index, OI and HI), we tested the influence of depth (n = 5), soil class (n = 6) and vegetation type (n = 3; deciduous, coniferous-fir, coniferous-pine) on SOM thermal stability and bulk chemistry. Results showed that depth was the dominant discriminating factor, affecting significantly all RE6 parameters. With depth, we observed a decrease of the thermally labile SOC pool and an increase of the thermally stable SOC pool, along with an oxidation and a depletion of hydrogen-rich moieties of the SOC. Soil class and vegetation type had contrasted effects on the RE6 parameters but both affected significantly T

  1. What can we learn from field experiments about the development of SOC and GHG emissions under different management practices?

    Science.gov (United States)

    Spiegel, Heide; Lehtinen, Taru; Schlatter, Norman; Haslmayr, Hans-Peter; Baumgarten, Andreas; ten Berge, Hein

    2015-04-01

    Successful agricultural management practices are required to maintain or enhance soil quality; at the same time climate change mitigation is becoming increasingly important. Within the EU project CATCH-C we analysed the effects of different agricultural practices not only on crop productivity, but also on soil quality indicators (e.g. soil organic carbon (SOC)) and climate change (CC) mitigation indicators (e.g. CO2, CH4, N2O emissions). European data sets and associated literature, mainly from long-term experiments were evaluated. This evaluation of agricultural management practices was carried out comparing a set of improved ("best") and often applied ("current") management practices. Positive and negative effects occurred when best management practices are adopted. As expected, none of the investigated practices could comply with all objectives simultaneously, i.e. maintaining high yields, mitigating climate change and improving chemical, physical and biological soil quality. The studied soil management practices "non-inversion tillage", "organic fertilisation" (application of farm yard manure, slurry, compost) and "incorporation of crop residues" represent important management practices for farmers to increase SOC, thus improving soil quality. However, CO2 and, especially, N2O emissions may rise as well. The evaluation of CC mitigation is often limited by the lack of data from - preferably - continuous GHG emission measurements. Thus, more long-term field studies are needed to better assess the CO2, CH4 and, especially, N2O emissions following the above mentioned favorably rated MPs. Only if SOC and GHG emissions are measured in the same field experiments, it will be possible to compute overall balances of necessary CO2-C equivalent emissions. CATCH-C is funded within the 7th Framework Programme for Research, Technological Development and Demonstration, Theme 2 - Biotechnologies, Agriculture & Food. (Grant Agreement N° 289782).

  2. Using SoC Online Correction Method Based on Parameter Identification to Optimize the Operation Range of NI-MH Battery for Electric Boat

    Directory of Open Access Journals (Sweden)

    Bumin Meng

    2018-03-01

    Full Text Available This paper discusses a design of a Battery Management System (BMS solution for extending the life of Nickel-Metal Hydride (NI-MH battery. Combined with application of electric boat, a State of Charge (SoC optimal operation range control method based on high precision energy metering and online SoC correction is proposed. Firstly, a power metering scheme is introduced to reduce the original energy measurement error. Secondly, by establishing a model based parameter identification method and combining with Extended Kalman Filter (EKF method, the estimation accuracy of SoC is guaranteed. Finally, SoC optimal operation range control method is presented to make battery running in the optimal range. After two years of operation, the battery managed by proposed method has much better status, compared to batteries that use AH integral method and fixed SoC operating range. Considering the SoC estimation of NI-MH battery is more difficult becausing special electrical characteristics, proposed method also would have a very good reference value for other types of battery management.

  3. Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling.

    Science.gov (United States)

    Farquharson, Colin; Ahmed, S Faisal

    2013-04-01

    Linear bone growth is widely recognized to be adversely affected in children with chronic kidney disease (CKD) and other chronic inflammatory disorders. The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) pathway is anabolic to the skeleton and inflammatory cytokines compromise bone growth through a number of different mechanisms, which include interference with the systemic as well as the tissue-level GH/IGF-1 axis. Despite attempts to promote growth and control disease, there are an increasing number of reports of the persistence of poor growth in a substantial proportion of patients receiving rhGH and/or drugs that block cytokine action. Thus, there is an urgent need to consider better and alternative forms of therapy that are directed specifically at the mechanism of the insult which leads to abnormal bone health. Suppressor of cytokine signaling 2 (SOCS2) expression is increased in inflammatory conditions including CKD, and is a recognized inhibitor of GH signaling. Therefore, in this review, we will focus on the premise that SOCS2 signaling represents a critical pathway in growth plate chondrocytes through which pro-inflammatory cytokines alter both GH/IGF-1 signaling and cellular function.

  4. The SOC in cells’ living expectations of Conway’s Game of Life and its extended version

    International Nuclear Information System (INIS)

    Wei, Jinling; Zhou, Haiyan; Meng, Jun; Zhang, Fan; Chen, Yunmo; Zhou, Su

    2016-01-01

    In self-organized systems such as Conway’s Game of Life (CGL). Wikipedia, Conway’s game of the life, (https://en.wikipedia.org/wiki/Conway%27s-Game-of-Life)., though whether the single cell will survive or die seems unpredictable, the log–log distribution of all cells living frequency satisfies the 1/f linear law, thus meets the Self-organized Criticality(SOC) rule, which not only proves that CGL is a self-organized system, but more significantly, that the chance of living for each cell is spatial heterogeneous, and is statistical fractal. After carried out CGL, the specified iterative period which begins with a random initial condition and ends when it reaches the homeostasis, add up all the states which the living cells are marked by 1s, and the dead are marked by 0s. The resulted sum picture consisting of cells having its gray level representing the living times during the iterative process. By plotting the gray level distribution of the sum picture on log–log scale, the graph indicates the spatial living expectations distributions. Then we find the curve of the graph satisfies the Self-organized Criticality(SOC) rule, showing its linear feature in the intermediate zone, which also has name of 1/f feature. To examine its universality, we designed a more complicated self-organized cellular automata with each cell having five possible states thus the rule table becomes more complicated. As expected, the consequence shows the similar feature, and the linear feature is even more obvious when the similar experiments are carried out. To conclude, it is a new discovery of SOC from a new perspective. And with the self-organized systems expanding to other different rule tables, this feature may still be satisfied. More further, considering the natural self-organized systems of living creatures, the spatial living expectations of different phenotypes may satisfy the 1/f law, too. Though we regard this as an inspirational orientation, the supposition needs more

  5. The impact of Moore's Law and loss of Dennard scaling: Are DSP SoCs an energy efficient alternative to x86 SoCs?

    International Nuclear Information System (INIS)

    Johnsson, L; Netzer, G

    2016-01-01

    Moore's law, the doubling of transistors per unit area for each CMOS technology generation, is expected to continue throughout the decade, while Dennard voltage scaling resulting in constant power per unit area stopped about a decade ago. The semiconductor industry's response to the loss of Dennard scaling and the consequent challenges in managing power distribution and dissipation has been leveled off clock rates, a die performance gain reduced from about a factor of 2.8 to 1.4 per technology generation, and multi-core processor dies with increased cache sizes. Increased caches sizes offers performance benefits for many applications as well as energy savings. Accessing data in cache is considerably more energy efficient than main memory accesses. Further, caches consume less power than a corresponding amount of functional logic. As feature sizes continue to be scaled down an increasing fraction of the die must be “underutilized” or “dark” due to power constraints. With power being a prime design constraint there is a concerted effort to find significantly more energy efficient chip architectures than dominant in servers today, with chips potentially incorporating several types of cores to cover a range of applications, or different functions in an application, as is already common for the mobile processor market. Digital Signal Processors (DSPs), largely targeting the embedded and mobile processor markets, typically have been designed for a power consumption of 10% or less of a typical x86 CPU, yet with much more than 10% of the floating-point capability of the same technology generation x86 CPUs. Thus, DSPs could potentially offer an energy efficient alternative to x86 CPUs. Here we report an assessment of the Texas Instruments TMS320C6678 DSP in regards to its energy efficiency for two common HPC benchmarks: STREAM (memory system benchmark) and HPL (CPU benchmark) (paper)

  6. The impact of Moore's Law and loss of Dennard scaling: Are DSP SoCs an energy efficient alternative to x86 SoCs?

    Science.gov (United States)

    Johnsson, L.; Netzer, G.

    2016-10-01

    Moore's law, the doubling of transistors per unit area for each CMOS technology generation, is expected to continue throughout the decade, while Dennard voltage scaling resulting in constant power per unit area stopped about a decade ago. The semiconductor industry's response to the loss of Dennard scaling and the consequent challenges in managing power distribution and dissipation has been leveled off clock rates, a die performance gain reduced from about a factor of 2.8 to 1.4 per technology generation, and multi-core processor dies with increased cache sizes. Increased caches sizes offers performance benefits for many applications as well as energy savings. Accessing data in cache is considerably more energy efficient than main memory accesses. Further, caches consume less power than a corresponding amount of functional logic. As feature sizes continue to be scaled down an increasing fraction of the die must be “underutilized” or “dark” due to power constraints. With power being a prime design constraint there is a concerted effort to find significantly more energy efficient chip architectures than dominant in servers today, with chips potentially incorporating several types of cores to cover a range of applications, or different functions in an application, as is already common for the mobile processor market. Digital Signal Processors (DSPs), largely targeting the embedded and mobile processor markets, typically have been designed for a power consumption of 10% or less of a typical x86 CPU, yet with much more than 10% of the floating-point capability of the same technology generation x86 CPUs. Thus, DSPs could potentially offer an energy efficient alternative to x86 CPUs. Here we report an assessment of the Texas Instruments TMS320C6678 DSP in regards to its energy efficiency for two common HPC benchmarks: STREAM (memory system benchmark) and HPL (CPU benchmark)

  7. Summer school in Kabardino-Balkaria by BMSTU SPIE Student Chapter

    Science.gov (United States)

    Chernomyrdin, Nikita V.; Zaytsev, Kirill I.; Gavdush, Arsenii A.; Fokina, Irina N.; Karasik, Valeriy E.; Yurchenko, Stanislav O.

    2014-09-01

    This summer BMSTU SPIE Student Chapter have decided to visit Kabardino-Balkaria Republic of Caucasus (Russia) and spent there a week with children in a camp. It was called Summer school. We decided to organize it in order to engage talented and curious children in Optics and to show them how science could be funny. Education and entertainment program included such activities as lectures, optical demonstrations, laser games, hiking in the forest, and others. As a result children had a good time outdoors, learned interesting facts about optics and lasers, and of course found new friends who are keen to know more too. Four Chapter members and about 70 children of age 10-16 took part in this event.

  8. Metal–organic frameworks to satisfy gas upgrading demands: fine-tuning the soc-MOF platform for the operative removal of H2S

    KAUST Repository

    Belmabkhout, Youssef

    2017-01-06

    A cooperative experimental/modeling strategy was used to unveil the structure/gas separation performance relationship for a series of isostructural metal-organic frameworks (MOFs) with soc-topology (square-octahedral) hosting different extra-framework counter ions (NO3-, Cl- and Br-). In3+-, Fe3+-, Ga3+-and the newly isolated Al(III)-based isostructural soc-MOF were extensively studied and evaluated for the separation-based production of high-quality fuels (i.e., CH4, C3H8 and n-C4H10) and olefins. The structural/chemical fine-tuning of the soc-MOF platform promoted equilibrium-based selectivity toward C2+ (C2H6, C2H4, C3H6 C3H8 and n-C4H10) and conferred the desired chemical stability toward H2S. The noted dual chemical stability and gas/vapor selectivity, which have rarely been reported for equilibrium-based separation agents, are essential for the production of high-purity H-2, CH4 and C2+ fractions in high yields. Interestingly, the evaluated soc-MOF analogues exhibited high selectivity for C2H4, C3H6 and n-C4H10. In particular, the Fe, Ga and Al analogues presented relatively enhanced C2+/CH4 adsorption selectivities. Notably, the Ga and Al analogues were found to be technically preferable because their structural integrities and separation performances were maintained upon exposure to H2S, indicating that these materials are highly tolerant to H2S. Therefore, the Ga-soc-MOF was further examined for the selective adsorption of H2S in the presence of CO2-and CH4-containing streams, such as refinery-off gases (ROG) and natural gas (NG). Grand canonical Monte Carlo (GCMC) simulations based on a specific force field describing the interactions between the guest molecules and the Ga sites supported and confirmed the considerably higher affinity of the Ga-soc-MOF for C2+ (as exemplified by n-C4H10) than for CH4. The careful selection of an appropriate metal for the trinuclear inorganic molecular building block (MBB), i. e., a Ga metal center, imbues the soc

  9. Metal–organic frameworks to satisfy gas upgrading demands: fine-tuning the soc-MOF platform for the operative removal of H2S

    KAUST Repository

    Belmabkhout, Youssef; Pillai, Renjith S.; Alezi, Dalal; Shekhah, Osama; Bhatt, Prashant; Chen, Zhijie; Adil, Karim; Vaesen, Sebastien; De Weireld, Guy; Pang, Maolin; Suetin, Mikhail; Cairns, Amy; Solovyeva, Vera; Shkurenko, Aleksander; El Tall, Omar; Maurin, Guillaume; Eddaoudi, Mohamed

    2017-01-01

    -framework counter ions (NO3-, Cl- and Br-). In3+-, Fe3+-, Ga3+-and the newly isolated Al(III)-based isostructural soc-MOF were extensively studied and evaluated for the separation-based production of high-quality fuels (i.e., CH4, C3H8 and n-C4H10) and olefins

  10. The ComSoc guide to passive optical networks enhancing the last mile access

    CERN Document Server

    Weinstein, Stephen B; Wang, Ting

    2012-01-01

    "The goal of this guidebook is to provide the general readers with a high level overview of the technology and applications behind the Fiber-to-the-Home (FTTH) or Fiber-to-the-Curb (FTTC) family of standards, which has recently attracted considerable amount of interest in the technical community"--

  11. Angiotensin II (AngII) induces the expression of suppressor of cytokine signaling (SOCS)-3 in rat hypothalamus - a mechanism for desensitization of AngII signaling.

    Science.gov (United States)

    Torsoni, Márcio A; Carvalheira, José B; Calegari, Vivian C; Bezerra, Rosangela M N; Saad, Mário J A; Gontijo, José A; Velloso, Lício A

    2004-04-01

    Angiotensin II exerts a potent dypsogenic stimulus on the hypothalamus, which contributes to its centrally mediated participation in the control of water balance and blood pressure. Repetitive intracerebroventricular (i.c.v.) injections of angiotensin II lead to a loss of effect characterized as physiological desensitization to the peptide's action. In the present study, we demonstrate that angiotensin II induces the expression of suppressor of cytokine signaling (SOCS)-3 via angiotensin receptor 1 (AT1) and JAK-2, mostly located at the median preoptic lateral and anterodorsal preoptic nuclei. SOCS-3 produces an inhibitory effect upon the signal transduction pathways of several cytokines and hormones that employ members of the JAK/STAT families as intermediaries. The partial inhibition of SOCS-3 translation by antisense oligonucleotide was sufficient to significantly reduce the refractoriness of repetitive i.c.v. angiotensin II injections, as evaluated by water ingestion. Thus, by acting through AT1 on the hypothalamus, angiotensin II induces the expression of SOCS-3 which, in turn, blocks further activation of the pathway and consequently leads to desensitization to angiotensin II stimuli concerning its dypsogenic effect.

  12. Early secreted antigen ESAT-6 of Mycobacterium Tuberculosis promotes apoptosis of macrophages via targeting the microRNA155-SOCS1 interaction.

    Science.gov (United States)

    Yang, Shaojun; Li, Fake; Jia, Shuangrong; Zhang, Kejun; Jiang, Wenbing; Shang, Ya; Chang, Kai; Deng, Shaoli; Chen, Ming

    2015-01-01

    The early secreted antigenic target 6-kDa protein (ESAT-6) of Mycobacterium tuberculosis (Mtb) not only acts as a key player for virulence but also exhibits a strong immunotherapeutic potential against Mtb. However, little is known about the molecular basis for its potential in immunotherapy. The present study was designed to unravel the role of miRNA-155 in ESAT-6-mediated enhancement of host immunity and apoptosis in macrophages. Lentivirus-mediated miR-155 sponge and miR-155 and SOCS1 overexpression vectors were developed in macrophages. TLR2- or p65-specific siRNA knockdown was employed to silence TLR2 or p65. Quantitative polymerase chain reaction and western blotting analyses were performed to determine mRNA and protein expression levels, respectively. Macrophage apoptosis was analyzed by flow cytometry. ESAT-6 significantly increased miR-155 expression, which was dependent on TLR2/NF-κB activation in macrophages. Induced expression of miRNA-155 was required for the ESAT-6-mediated protective immune response and macrophage apoptosis. ESAT-6 promoted macrophage apoptosis by targeting the miR-155-SOCS1 pathway. The differential expression levels of TLR2, BIC, and SOCS1 were involved in regulating the immune response in human peripheral blood mononuclear cells of patients with active tuberculosis (TB) and latent TB (LTB). ESAT-6 promotes apoptosis of macrophages via targeting the miRNA155-SOCS1 interaction. © 2015 S. Karger AG, Basel.

  13. Early Secreted Antigen ESAT-6 of Mycobacterium Tuberculosis Promotes Apoptosis of Macrophages via Targeting the MicroRNA155-SOCS1 Interaction

    Directory of Open Access Journals (Sweden)

    Shaojun Yang

    2015-02-01

    Full Text Available Background: The early secreted antigenic target 6-kDa protein (ESAT-6 of Mycobacterium tuberculosis (Mtb not only acts as a key player for virulence but also exhibits a strong immunotherapeutic potential against Mtb. However, little is known about the molecular basis for its potential in immunotherapy. The present study was designed to unravel the role of miRNA-155 in ESAT-6-mediated enhancement of host immunity and apoptosis in macrophages. Methods: Lentivirus-mediated miR-155 sponge and miR-155 and SOCS1 overexpression vectors were developed in macrophages. TLR2- or p65-specific siRNA knockdown was employed to silence TLR2 or p65. Quantitative polymerase chain reaction and western blotting analyses were performed to determine mRNA and protein expression levels, respectively. Macrophage apoptosis was analyzed by flow cytometry. Results: ESAT-6 significantly increased miR-155 expression, which was dependent on TLR2/NF-κB activation in macrophages. Induced expression of miRNA-155 was required for the ESAT-6-mediated protective immune response and macrophage apoptosis. ESAT-6 promoted macrophage apoptosis by targeting the miR-155-SOCS1 pathway. The differential expression levels of TLR2, BIC, and SOCS1 were involved in regulating the immune response in human peripheral blood mononuclear cells of patients with active tuberculosis (TB and latent TB (LTB. Conclusion: ESAT-6 promotes apoptosis of macrophages via targeting the miRNA155-SOCS1 interaction.

  14. Modeling of SOC-700 Hyperspectral Imagery with the CAMEO-SIM Code

    National Research Council Canada - National Science Library

    Evans, Roger

    2007-01-01

    The CAMEO-SIM software program provides a physics-based spectral radiance simulation over the complete range from UV to Far-IR, the only real limitation being one of obtaining the necessary input data...

  15. Soc dynamics in a 2D model of turbulent particle transport in the sol

    International Nuclear Information System (INIS)

    Ghendrih, Ph.; Sarazin, Y.

    1998-01-01

    Interchange turbulence in two-dimensions is investigated in the Scrape-Off Layer of fusion devices, when driven by a constant core particle influx. Contrary to the standard gradient driven approach, density is allowed to fluctuate around its average profile. Transverse transport exhibits some of the features of Self-organised Critical systems, namely, inward and outward avalanches, together with a frequency spectrum decrease in 1 / f and f -2 at intermediate and high frequencies respectively. An avalanches occurs when follows the large radial structures of the electric potential. As experimentally, the radial profile of density relative fluctuations decreases from the wall into the core plasma, while that of density relative fluctuations peaks inside the SOL. Equilibrium density exhibits the experimental exponential decrease. An analytical expression of the SOL width Δ SOL is obtained, which maximizes the linear growth rate, when the poloidal modulation of electric potential equilibrium is taken into account. The parametric dependence of Δ SOL well agrees with experimental data. (authors)

  16. A simple 2D SOC model for one of the main sources of geomagnetic disturbances: Flares

    International Nuclear Information System (INIS)

    Meirelles, M.C.; Dias, V.H.A.; Oliva, D.; Papa, A.R.R.

    2010-01-01

    We introduce a simple model for solar flares, one of the main sources of geomagnetic disturbances. We have obtained power-laws for the probability distribution functions of some relevant physical characteristics of flares which could serve as the fingerprint of a critical state at the base of such phenomena and, given that we have not introduced a fine tune mechanism, of self-organized criticality. We compare our results with some recent experimental work on the statistics of flares and analyze the possible connection of these power laws with others already found by our group in geomagnetic disturbances distributions. We also present some limitations of our model as well as possible extensions and corrections to be taken into account in future works.

  17. The effect of interferon treatment on STAT/SOCS status in normal and malignant human breast cells

    Czech Academy of Sciences Publication Activity Database

    Součková Skalická, Kamila; Adámková, L.; Lauerová, L.; Krejčí, E.; Kovařík, Aleš; Fojtová, Miloslava; Matoušková, Eva; Buršíková, Eva; Kovařík, J.; Boudný, V.

    2006-01-01

    Roč. 17, č. 9 (2006), ix65-ix65 ISSN 0923-7534. [31st ESMO Congress. 29.09.2006-03.10.2006, Istanbul] R&D Projects: GA MZd(CZ) NR8341; GA ČR(CZ) GA301/06/0912; GA AV ČR(CZ) KJB502070601 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50520514 Keywords : interferon * breast * STAT/SOCS Subject RIV: BO - Biophysics

  18. Postlingual deaf speech and the role of audition in speech production: comments on Waldstein's paper [R.S. Waldstein, J. Acoust. Soc. Am. 88, 2099-2114 (1990)].

    Science.gov (United States)

    Sapir, S; Canter, G J

    1991-09-01

    Using acoustic analysis techniques, Waldstein [J. Acoust. Soc. Am. 88, 2099-2114 (1990] reported abnormal speech findings in postlingual deaf speakers. She interpreted her findings to suggest that auditory feedback is important in motor speech control. However, it is argued here that Waldstein's interpretation may be unwarranted without addressing the possibility of neurologic deficits (e.g., dysarthria) as confounding (or even primary) causes of the abnormal speech in her subjects.

  19. Progress in semiconductor laser diodes: SPIE volume 723

    International Nuclear Information System (INIS)

    Eichen, E.

    1987-01-01

    This book contains proceedings arranged under the following session headings: High power diode lasers; single emitters and arrays; Ultrahigh speed modulation of semiconductor diode lasers; Coherence and linewidth stabilized semiconductor lasers; and Growth, fabrication, and evaluation of laser diodes

  20. Optical techniques in pulmonary medicine. SPIE photonics West.

    Science.gov (United States)

    Suter, Melissa J; Lam, Stephen; Brenner, Matthew

    2012-04-01

    There is ongoing interest in the emerging field of pulmonary photonic-based diagnostics. Potential clinical need areas that are being actively investigated at this time include airway and peripheral lung cancer diagnostics, pulmonary parenchymal and interstitial disorders, alveolar structure function, inhalation injury, ciliary function analysis, asthma and obstructive lung diseases.

  1. Research on SOC Calibration of Large Capacity Lead Acid Battery

    Science.gov (United States)

    Ye, W. Q.; Guo, Y. X.

    2018-05-01

    Large capacity lead-acid battery is used in track electric locomotive, and State of Charge (SOC) is an important quantitative parameter of locomotive power output and operating mileage of power emergency recovery vehicle. But State of Charge estimation has been a difficult part in the battery management system. In order to reduce the SOC estimation error better, this paper uses the linear relationship of Open Circuit Voltage (OCV) and State of Charge to fit the SOC-OCV curve equation by MATLAB. The method proposed in this paper is small, easy to implement and can be used in the battery non-working state SOC estimation correction, improve the estimation accuracy of SOC.

  2. A method for the densification of ceramic layers, especially ceramic layers within solid oxide cell (SOC) technology, and products obtained by the method

    DEFF Research Database (Denmark)

    2013-01-01

    A ceramic layer, especially for use in solid oxide cell (SOC) technology, is densified in a method comprising (a) providing a multilayer system by depositing the porous ceramic layer, which is to be densified, onto the selected system of ceramic layers on a support, (b) pre-sintering the resulting......(s) in the porous layer surface and (e) performing a thermal treatment at a temperature T2, where T2 > ?1, to obtain densification of and grain growth in the porous layer formed in step (b). The method makes it possible to obtain dense ceramic layers at temperatures, which are compatible with the other materials...... present in a ceramic multilayer system....

  3. Preliminary Electrochemical Characterization of Anode Supported Solid Oxide Cell (AS-SOC) Produced in the Institute of Power Engineering Operated in Electrolysis Mode (SOEC)

    Science.gov (United States)

    Kupecki, Jakub; Motyliński, Konrad; Skrzypkiewicz, Marek; Wierzbicki, Michał; Naumovich, Yevgeniy

    2017-12-01

    The article discusses the operation of solid oxide electrochemical cells (SOC) developed in the Institute of Power Engineering as prospective key components of power-to-gas systems. The fundamentals of the solid oxide cells operated as fuel cells (SOFC - solid oxide fuel cells) and electrolysers (SOEC - solid oxide fuel cells) are given. The experimental technique used for electrochemical characterization of cells is presented. The results obtained for planar cell with anodic support are given and discussed. Based on the results, the applicability of the cells in power-to-gas systems (P2G) is evaluated.

  4. Ankyrin repeat and SOCS box containing protein 4 (Asb-4 colocalizes with insulin receptor substrate 4 (IRS4 in the hypothalamic neurons and mediates IRS4 degradation

    Directory of Open Access Journals (Sweden)

    Xia Zefeng

    2011-09-01

    Full Text Available Abstract Background The arcuate nucleus of the hypothalamus regulates food intake. Ankyrin repeat and SOCS box containing protein 4 (Asb-4 is expressed in neuropeptide Y and proopiomelanocortin (POMC neurons in the arcuate nucleus, target neurons in the regulation of food intake and metabolism by insulin and leptin. However, the target protein(s of Asb-4 in these neurons remains unknown. Insulin receptor substrate 4 (IRS4 is an adaptor molecule involved in the signal transduction by both insulin and leptin. In the present study we examined the colocalization and interaction of Asb-4 with IRS4 and the involvement of Asb-4 in insulin signaling. Results In situ hybridization showed that the expression pattern of Asb-4 was consistent with that of IRS4 in the rat brain. Double in situ hybridization showed that IRS4 colocalized with Asb-4, and both Asb-4 and IRS4 mRNA were expressed in proopiomelanocortin (POMC and neuropeptide Y (NPY neurons within the arcuate nucleus of the hypothalamus. In HEK293 cells co-transfected with Myc-tagged Asb-4 and Flag-tagged IRS4, Asb-4 co-immunoprecipitated with IRS4; In these cells endogenous IRS4 also co-immunoprecipitated with transfected Myc-Asb-4; Furthermore, Asb-4 co-immunoprecipitated with IRS4 in rat hypothalamic extracts. In HEK293 cells over expression of Asb-4 decreased IRS4 protein levels and deletion of the SOCS box abolished this effect. Asb-4 increased the ubiquitination of IRS4; Deletion of SOCS box abolished this effect. Expression of Asb-4 decreased both basal and insulin-stimulated phosphorylation of AKT at Thr308. Conclusions These data demonstrated that Asb-4 co-localizes and interacts with IRS4 in hypothalamic neurons. The interaction of Asb-4 with IRS4 in cell lines mediates the degradation of IRS4 and decreases insulin signaling.

  5. SOCS2 and SOCS3 expression in ulcerative colitis and their correlation with inflammatory response and immune response

    Directory of Open Access Journals (Sweden)

    Le Huang1

    2017-05-01

    Full Text Available Objective: To study the correlation of SOCS2 and SOCS3 expression in ulcerative colitis tissue with inflammatory response and immune response. Methods: Ulcerative colitis lesions and normal mucosa from colonoscopic biopsy in Central Hospital of Zibo Mining Refco Group Ltd between May 2014 and July 2016 were selected and enrolled in UC group and control group respectively. RNA was extracted to determine mRNA expression of SOCS2 and SOCS3 as well as inflammatory response JAKs/STATs pathway molecules; protein was extracted to determine the contents of immune response cytokines. Results: SOCS2 mRNA expression in intestinal mucosa of UC group was not significantly different from that of control group, and SOCS3 mRNA expression was significantly lower than that of control group; JAK1, JAK2, JAK3, STAT1, STAT3 and STAT5 mRNA expression as well as IFN-γ and IL-17 protein contents in intestinal mucosa of UC group were significantly higher than those of control group while IL-4 and IL-10 protein contents were significantly lower than those of control group; JAK1, JAK2, JAK3, STAT1, STAT3 and STAT5 mRNA expression as well as IFN-γ and IL-17 protein contents in UC group of intestinal mucosa with low SOCS3 expression were significantly higher than those of intestinal mucosa with high SOCS3 expression while IL-4 and IL-10 protein contents were significantly lower than those of intestinal mucosa with high SOCS3 expression. Conclusion: Low expression of SOCS3 in ulcerative colitis can aggravate the inflammatory reaction and cause the imbalance of Th1/Th2 and Th17/Treg immune response.

  6. The ZYNQ book embedded processing with the ARM Cortex-A9 on the Xilinx Zynq-7000 all programmable SoC

    CERN Document Server

    Crockett, Louise H; Enderwitz, Martin A; Stewart, Robert W

    2014-01-01

    This book is about the Zynq-7000 All Programmable System on Chip, the family of devices from Xilinx that combines an application-grade ARM Cortex-A9 processor with traditional FPGA logic fabric. Catering for both new and experienced readers, it covers fundamental issues in an accessible way, starting with a clear overview of the device architecture, and an introduction to the design tools and processes for developing a Zynq SoC. Later chapters progress to more advanced topics such as embedded systems development, IP block design and operating systems. Maintaining a 'real-world' perspective, the book also compares Zynq with other device alternatives, and considers end-user applications. The Zynq Book is accompanied by a set of practical tutorials hosted on a companion website. These tutorials will guide the reader through first steps with Zynq, following on to a complete, audio-based embedded systems design.

  7. SOCS-1 deficiency does not prevent diet-induced insulin resistance

    DEFF Research Database (Denmark)

    Emanuelli, Brice; Macotela, Yazmin; Boucher, Jérémie

    2008-01-01

    Obesity is associated with inflammation and increased expression of suppressor of cytokine signaling (SOCS) proteins, which inhibit cytokine and insulin signaling. Thus, reducing SOCS expression could prevent the development of obesity-induced insulin resistance. Using SOCS-1 knockout mice, we...... investigated the contribution of SOCS-1 in the development of insulin resistance induced by a high-fat diet (HFD). SOCS-1 knockout mice on HFD gained 70% more weight, displayed a 2.3-fold increase in epididymal fat pads mass and increased hepatic lipid content. This was accompanied by increased mRNA expression...... of leptin and the macrophage marker CD68 in white adipose tissue and of SREBP1c and FAS in liver. HFD also induced hyperglycemia in SOCS-1 deficient mice with impairment of glucose and insulin tolerance tests. Thus, despite the role of SOCS proteins in obesity-related insulin resistance, SOCS-1 deficiency...

  8. Suppressor of cytokine signaling (SOCS genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells.

    Directory of Open Access Journals (Sweden)

    Moon-Hong Kim

    Full Text Available Suppressor of cytokine signaling (SOCS family is an important negative regulator of cytokine signaling and deregulation of SOCS has been involved in many types of cancer. All cervical cancer cell lines tested showed lower expression of SOCS1, SOCS3, and SOCS5 than normal tissue or cell lines. The immunohistochemistry result for SOCS proteins in human cervical tissue also confirmed that normal tissue expressed higher level of SOCS proteins than neighboring tumor. Similar to the regulation of SOCS in other types of cancer, DNA methylation contributed to SOCS1 downregulation in CaSki, ME-180, and HeLa cells. However, the expression of SOCS3 or SOCS5 was not recovered by the inhibition of DNA methylation. Histone deacetylation may be another regulatory mechanism involved in SOCS1 and SOCS3 expression, however, SOCS5 expression was neither affected by DNA methylation nor histone deacetylation. Ectopic expression of SOCS1 or SOCS3 conferred radioresistance to HeLa cells, which implied SOCS signaling regulates the response to radiation in cervical cancer. In this study, we have shown that SOCS expression repressed by, in part, epigenetically and altered SOCS1 and SOCS3 expression could contribute to the radiosensitive phenotype in cervical cancer.

  9. Essential issues in SOC design designing complex systems-on-chip

    CERN Document Server

    Lin, Youn-long Steve

    2007-01-01

    Covers issues related to system-on-chip (SoC) design. This book covers IP development, verification, integration, chip implementation, testing and software. It contains valuable academic and industrial examples for those involved with the design of complex SOCs.

  10. A fully integrated UHF RFID reader SoC for handheld applications in the 0.18 μm CMOS process

    International Nuclear Information System (INIS)

    Wang Jingchao; Zhang Chun; Wang Zhihua

    2010-01-01

    A low cost fully integrated single-chip UHF radio frequency identification (RFID) reader SoC for short distance handheld applications is presented. The SoC integrates all building blocks-including an RF transceiver, a PLL frequency synthesizer, a digital baseband and an MCU-in a 0.18 μm CMOS process. A high-linearity RX front-end is designed to handle the large self-interferer. A class-E power amplifier with high power efficiency is also integrated to fulfill the function of a UHF passive RFID reader. The measured maximum output power of the transmitter is 20.28 dBm and the measured receiver sensitivity is -60 dBm. The digital baseband including MCU core consumes 3.91 mW with a clock of 10 MHz and the analog part including power amplifier consumes 368.4 mW. The chip has a die area of 5.1 x 3.8 mm 2 including pads. (semiconductor integrated circuits)

  11. A fully integrated UHF RFID reader SoC for handheld applications in the 0.18 {mu}m CMOS process

    Energy Technology Data Exchange (ETDEWEB)

    Wang Jingchao; Zhang Chun; Wang Zhihua, E-mail: wangjc@gmail.co [Institute of Microelectronics, Tsinghua University, Beijing 100084 (China)

    2010-08-15

    A low cost fully integrated single-chip UHF radio frequency identification (RFID) reader SoC for short distance handheld applications is presented. The SoC integrates all building blocks-including an RF transceiver, a PLL frequency synthesizer, a digital baseband and an MCU-in a 0.18 {mu}m CMOS process. A high-linearity RX front-end is designed to handle the large self-interferer. A class-E power amplifier with high power efficiency is also integrated to fulfill the function of a UHF passive RFID reader. The measured maximum output power of the transmitter is 20.28 dBm and the measured receiver sensitivity is -60 dBm. The digital baseband including MCU core consumes 3.91 mW with a clock of 10 MHz and the analog part including power amplifier consumes 368.4 mW. The chip has a die area of 5.1 x 3.8 mm{sup 2} including pads. (semiconductor integrated circuits)

  12. SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

    DEFF Research Database (Denmark)

    Brender, Christine; Columbus, Ruth; Metcalf, Donald

    2004-01-01

    the importance of SOCS5 in T helper cell responses. Unexpectedly, SOCS5-deficient CD4 T cells showed no abnormalities in Th1/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major. Therefore, although SOCS5 is expressed in primary B and T cells, it appears...

  13. Settling-velocity specific SOC distribution on hillslopes

    DEFF Research Database (Denmark)

    Hu, Yaxian; Berhe, Asmeret Asefaw; Fogel, Marilyn L.

    The net effect of soil erosion by water, as a sink or source of atmospheric CO2, is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC). The depositional position of eroded SOC is a function of the transport distances of soil fractions where the SOC...... fractions. Eroding sandy soils and sediment were sampled after a series of rainfall events along a slope on a freshly seeded cropland in Jutland, Denmark. All the soil samples were fractionated into five settling classes using a settling tube apparatus. The spatial distribution of soil settling classes...... shows a coarsening effect immediately below the eroding slope, followed by a fining trend at the slope tail. The 13C values of soil fractions were more positive at the footslope than on the slope shoulder or at the slope tail, suggesting enhanced decomposition rate of fresh SOC input at the footslope...

  14. The ubiquitin ligase Cullin5SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation

    DEFF Research Database (Denmark)

    Paul, Indranil; Batth, Tanveer S; Iglesias-Gato, Diego

    2017-01-01

    SOCS2 is a pleiotropic E3 ligase. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. However, mechanistic understanding of SOCS2 function is dismal due to our unawareness of its protein substrates. We performed a mass spectrometry based proteomic pro...

  15. A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2 Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model.

    Directory of Open Access Journals (Sweden)

    Rachel Rupp

    2015-12-01

    Full Text Available Mastitis is an infectious disease mainly caused by bacteria invading the mammary gland. Genetic control of susceptibility to mastitis has been widely evidenced in dairy ruminants, but the genetic basis and underlying mechanisms are still largely unknown. We describe the discovery, fine mapping and functional characterization of a genetic variant associated with elevated milk leukocytes count, or SCC, as a proxy for mastitis. After implementing genome-wide association studies, we identified a major QTL associated with SCC on ovine chromosome 3. Fine mapping of the region, using full sequencing with 12X coverage in three animals, provided one strong candidate SNP that mapped to the coding sequence of a highly conserved gene, suppressor of cytokine signalling 2 (Socs2. The frequency of the SNP associated with increased SCC was 21.7% and the Socs2 genotype explained 12% of the variance of the trait. The point mutation induces the p.R96C substitution in the SH2 functional domain of SOCS2 i.e. the binding site of the protein to various ligands, as well-established for the growth hormone receptor GHR. Using surface plasmon resonance we showed that the p.R96C point mutation completely abrogates SOCS2 binding affinity for the phosphopeptide of GHR. Additionally, the size, weight and milk production in p.R96C homozygote sheep, were significantly increased by 24%, 18%, and 4.4%, respectively, when compared to wild type sheep, supporting the view that the point mutation causes a loss of SOCS2 functional activity. Altogether these results provide strong evidence for a causal mutation controlling SCC in sheep and highlight the major role of SOCS2 as a tradeoff between the host's inflammatory response to mammary infections, and body growth and milk production, which are all mediated by the JAK/STAT signaling pathway.

  16. Comment on "Relative variance of the mean squared pressure in multimode media: rehabilitating former approaches" [J. Acoust. Soc. Am. 136, 2621-2629 (2014)].

    Science.gov (United States)

    Davy, John L; Weaver, Richard L

    2015-03-01

    Models for the statistics of responses in finite reverberant structures, and in particular, for the variance of the mean square pressure in reverberation rooms, have been studied for decades. It is therefore surprising that a recent communication has claimed that the literature has gotten the simplest of such calculations very wrong. Monsef, Cozza, Rodrigues, Cellard, and Durocher [(2014). J. Acoust. Soc. Am. 136, 2621-2629] have derived a modal-based expression for the relative variance that differs significantly from expressions that have been accepted since 1969. This Comment points out that the Monsef formula is clearly incorrect, and then for the interested reader, points out the subtle place where they made their mistake.

  17. STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

    DEFF Research Database (Denmark)

    Brender, C; Nielsen, M; Kaltoft, K

    2001-01-01

    ) obtained from affected skin from a patient with mycosis fungoides (MF) and from peripheral blood from a patient with Sezary syndrome (SS). In contrast, constitutive SOCS-3 expression is not found in the leukemic Jurkat T-cell line, the MOLT-4 acute lymphoblastic leukemia cell line, and the monocytic......, it has been hypothesized that an aberrant SOCS expression plays a role in neoplastic transformation. This study reports on a constitutive SOCS-3 expression in cutaneous T-cell lymphoma (CTCL) cell lines. SOCS-3 protein is constitutively expressed in tumor cell lines (but not in nonmalignant T cells...... leukemic cell line U937. Expression of SOCS-3 coincides with a constitutive activation of STAT3 in CTCL tumor cells, and stable transfection of CTCL tumor cells with a dominant negative STAT3 strongly inhibits SOCS-3 expression, whereas transfection with wild-type STAT3 does not. Moreover, the reduced SOCS...

  18. Applying transport-distance specific SOC distribution to calibrate soil erosion model WaTEM

    Science.gov (United States)

    Hu, Yaxian; Heckrath, Goswin J.; Kuhn, Nikolaus J.

    2016-04-01

    Slope-scale soil erosion, transport and deposition fundamentally decide the spatial redistribution of eroded sediments in terrestrial and aquatic systems, which further affect the burial and decomposition of eroded SOC. However, comparisons of SOC contents between upper eroding slope and lower depositional site cannot fully reflect the movement of eroded SOC in-transit along hillslopes. The actual transport distance of eroded SOC is decided by its settling velocity. So far, the settling velocity distribution of eroded SOC is mostly calculated from mineral particle specific SOC distribution. Yet, soil is mostly eroded in form of aggregates, and the movement of aggregates differs significantly from individual mineral particles. This urges a SOC erodibility parameter based on actual transport distance distribution of eroded fractions to better calibrate soil erosion models. Previous field investigation on a freshly seeded cropland in Denmark has shown immediate deposition of fast settling soil fractions and the associated SOC at footslopes, followed by a fining trend at the slope tail. To further quantify the long-term effects of topography on erosional redistribution of eroded SOC, the actual transport-distance specific SOC distribution observed on the field was applied to a soil erosion model WaTEM (based on USLE). After integrating with local DEM, our calibrated model succeeded in locating the hotspots of enrichment/depletion of eroded SOC on different topographic positions, much better corresponding to the real-world field observation. By extrapolating into repeated erosion events, our projected results on the spatial distribution of eroded SOC are also adequately consistent with the SOC properties in the consecutive sample profiles along the slope.

  19. Variation tolerant SoC design

    Science.gov (United States)

    Kozhikkottu, Vivek J.

    performance distribution. This task is particularly complex and challenging due to the inter-dependencies between components' execution, indirect effects of shared resources, and interactions between multiple system-level "execution paths". We argue that accurate variation-aware performance analysis requires Monte-Carlo based repeated system execution. Our proposed analysis framework leverages emulation to significantly speedup performance analysis without sacrificing the generality and accuracy achieved by Monte-Carlo based simulations. Our experiments show performance improvements of around 60x compared to state-of-the-art hardware-software co-simulation tools and also underscore the framework's potential to enable variation-aware design and exploration at the system level. Our second contribution addresses the problem of designing variation-tolerant SoCs using recovery based design, a popular circuit design paradigm that addresses variations by eliminating guard-bands and operating circuits at close to "zero margins" while detecting and recovering from timing errors. While previous efforts have demonstrated the potential benefits of recovery based design, we identify several challenges that need to be addressed in order to apply this technique to SoCs. We present a systematic design framework to apply recovery based design at the system level. We propose to partition SoCs into "recovery islands", wherein each recovery island consists of one or more SoC components that can recover independent of the rest of the SoC. We present a variation-aware design methodology that partitions a given SoC into recovery islands and computes the optimal operating points for each island, taking into account the various trade-offs involved. Our experiments demonstrate that the proposed design framework achieves an average of 32% energy savings over conventional worst-case designs, with negligible losses in performance. The third contribution of this thesis introduces disproportionate

  20. PREFACE: 3rd International Symposium ''Optics and its Applications''

    Science.gov (United States)

    Calvo, M. L.; Dolganova, I. N.; Gevorgyan, N.; Guzman, A.; Papoyan, A.; Sarkisyan, H.; Yurchenko, S.

    2016-01-01

    The SPIE.FOCUS Armenia: 3rd International Symposium ''Optics and its Applications'' (OPTICS-2015) http://rau.am/optics2015/ was held in Yerevan, Armenia, in the period October 1 - 5, 2015. The symposium was organized by the International Society for Optics and Photonics (SPIE), the Armenian SPIE student chapter with collaboration of the Armenian TC of ICO, the Russian-Armenian University (RAU), the Institute for Physical Research of National Academy of Sciences of Armenia (IPR of NAS), the Greek-Armenian industrial company LT-PYRKAL, and the Yerevan State University (YSU). The Symposium was co-organized by the SPIE & OSA student chapters of BMSTU, the Armenian OSA student chapter, and the SPIE student chapters of Lund University and Wroclaw University of Technology. The symposium OPTICS-2015 was dedicated to the International Year of Light and Light-Based Technologies. OPTICS-2015 was devoted to modern topics and optical technologies such as: optical properties of nanostructures, silicon photonics, quantum optics, singular optics & its applications, laser spectroscopy, strong field optics, biomedical optics, nonlinear & ultrafast optics, photonics & fiber optics, and mathematical methods in optics. OPTICS-2015 was attended by 100 scientists and students representing 17 countries: Armenia, China, Czech Republic, France, Georgia, Germany, India, Iran, Italy, Latvia, Mexico, Poland, Russia, Saudi Arabia, Sweden, Ukraine, and USA. Such a broad international community confirmed the important mission of science to be a uniting force between different countries, religions, and nations. We hope that OPTICS-2015 inspired and motivated students and young scientists to work in optics and in science in general. The present volume of Journal of Physics: Conference Series includes proceedings of the symposium covering various aspects of modern problems in optics. We are grateful to all people who were involved in the organization process. We gratefully acknowledge support from

  1. SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro

    Directory of Open Access Journals (Sweden)

    Zhang Qingfu

    2008-05-01

    Full Text Available Abstract Background Suppressor of cytokine signaling 3 (SOCS3 is considered to inhibit cytokine responses and play a negative role in migration of various cells. Proline-rich tyrosine kinase 2 (PYK2 is a non-receptor kinase and has been found crucial to cell motility. However, little is known about whether SOCS3 could regulate PYK2 pro-migratory function in lung cancer. Methods The methylation status of SOCS3 was investigated in HBE and A549 cell lines by methylation-specific PCR. A549 cells were either treated with a demethylation agent 5-aza-2'-deoxycytidine or transfected with three SOCS3 mutants with various functional domains deleted. Besides, cells were pretreated with a proteasome inhibitor β-lactacystin where indicated. The effects of SOCS3 up-regulation on PYK2 expression, PYK2 and ERK1/2 phosphorylations were assessed by western blot using indicated antibodies. RT-PCR was used to estimate PYK2 mRNA levels. Transwell experiments were performed to evaluate cell migration. Results SOCS3 expression was found impaired in A549 cells and higher PYK2 activity was correlated with enhanced cell migration. We identified that SOCS3 was aberrantly methylated in the exon 2, and 5-aza-2'-deoxycytidine restored SOCS3 expression. Reactivation of SOCS3 attenuated PYK2 expression and phosphorylation, cell migration was inhibited as well. Transfection studies indicated that exogenous SOCS3 interacted with PYK2, and both the Src homology 2 (SH2 and the kinase inhibitory region (KIR domains of SOCS3 contributed to PYK2 binding. Furthermore, SOCS3 was found to inhibit PYK2-associated ERK1/2 activity in A549 cells. SOCS3 possibly promoted degradation of PYK2 in a SOCS-box-dependent manner and interfered with PYK2-related signaling events, such as cell migration. Conclusion These data indicate that SOCS3 negatively regulates cell motility and decreased SOCS3 induced by methylation may confer a migration advantage to A549 cells. These results also suggest a

  2. Measurement and Management of the Level of Quality Control Process in SoC (System on Chip Embedded Software Development

    Directory of Open Access Journals (Sweden)

    Ki-Won Song

    2012-04-01

    Full Text Available This paper presents the process of measuring the level of quality control process to ensure the quality of delivered software package during the development cycle. The success of the project requires three pre-requisites and they constrain one another. Quality is the most important factor for successful project completion. In other words, quality should not be sacrificed for the sake of meeting cost budget or delivering within schedule. Also, cost caused by any quality issues such as defect resolution increases exponentially once the product is out of the door. Having said that, we also have to consider the schedule side of constraints for the successful project. In other words, we have no time to do a quality job and we have to compete with other competitors to ship the product to the market earlier than them. So, the quality measurement and management concept is introduced to meet the agile software development environment in conjunction with performance strategies to execute within organization. Obviously, there are many key performance indexes derivable from the actual data associated with quality control activities and it is desirable to create a quality process to integrally represent overall level of quality control activities performed while developing the software deliverables. With the quality process, it is possible to evaluate whether enough quality control activities are performed for the project officially and secure the quality of the software deliverables before it is delivered to the customers.

  3. NIRS as an alternative to conventional soil analysis for Greenland soils (focus on SOC)

    DEFF Research Database (Denmark)

    Knadel, Maria; Ogric, Mateja; Adhikari, Kabindra

    Soil organic carbon (SOC) is an important soil property. It is the main constituents of soil organic matter and a good indicator of soil quality. The estimation and mapping of SOC content could be used to select potential agricultural areas in the Arctic areas. However, conventional analysis of SOC...... are time consuming and expensive. They involve a lot of sample preparation, and chemicals and are destructive. Near infrared spectroscopy (NIRS) in the range between 400 and 2500 nm is an alternative method for SOC analysis. It is fast and non-destructive. The aims of this study where to test...... the feasibility of using NIRS to estimate SOC content on a landscape and field scale in Greenland. Partial Least squares regression models were built to correlated soil spectra and their reference SOC data to develop calibration models. Very good predictive ability for both landscape and field scale were obtained...

  4. Simulating SOC changes in 11 land use change chronosequences from the Brazilian Amazon with RothC and Century models

    NARCIS (Netherlands)

    Cerri, C.E.P.; Easter, M.; Paustian, K.; Killian, K.; Coleman, K.; Bernoux, M.; Falloon, P.; Powlson, D.S.; Batjes, N.H.; Milne, E.; Cerri, C.C.

    2007-01-01

    Land use and land cover changes in the Brazilian Amazon have major implications for regional and global carbon (C) cycling. Cattle pasture represents the largest single use (about 70%) of this once-forested land in most of the region. The main objective of this study was to evaluate the accuracy of

  5. Selection of key terrain attributes for SOC model

    DEFF Research Database (Denmark)

    Greve, Mogens Humlekrog; Adhikari, Kabindra; Chellasamy, Menaka

    As an important component of the global carbon pool, soil organic carbon (SOC) plays an important role in the global carbon cycle. SOC pool is the basic information to carry out global warming research, and needs to sustainable use of land resources. Digital terrain attributes are often use...... was selected, total 2,514,820 data mining models were constructed by 71 differences grid from 12m to 2304m and 22 attributes, 21 attributes derived by DTM and the original elevation. Relative importance and usage of each attributes in every model were calculated. Comprehensive impact rates of each attribute...

  6. How do developmental and accommodative HRM enhance employee engagement and commitment? : The role of psychological contract and SOC-strategies

    NARCIS (Netherlands)

    Bal, P.M.; Kooij, T.A.M.; de Jong, S.B.

    2013-01-01

    In the context of the changing workforce, this study introduced two perspectives on HRM and distinguished universalistic developmental HRM from contingent accommodative HRM. We predicted two separate pathways for the effects on two employee outcomes: work engagement and affective commitment. We

  7. Estimation of power lithium-ion battery SOC based on fuzzy optimal decision

    Science.gov (United States)

    He, Dongmei; Hou, Enguang; Qiao, Xin; Liu, Guangmin

    2018-06-01

    In order to improve vehicle performance and safety, need to accurately estimate the power lithium battery state of charge (SOC), analyzing the common SOC estimation methods, according to the characteristics open circuit voltage and Kalman filter algorithm, using T - S fuzzy model, established a lithium battery SOC estimation method based on the fuzzy optimal decision. Simulation results show that the battery model accuracy can be improved.

  8. Gaining Insights on the H2–Sorbent Interactions: Robust soc-MOF Platform as a Case Study

    KAUST Repository

    Cairns, Amy; Eckert, Juergen; Wojtas, Lukasz; Thommes, Matthias; Wallacher, Dirk; Georgiev, Peter A.; Forster, Paul M.; Belmabkhout, Youssef; Ollivier, Jacques; Eddaoudi, Mohamed

    2016-01-01

    platform to examine the impact of specific structural parameters on H2–MOF interactions via systematic gas adsorption studies. We infer that enhanced binding of molecular H2 is primarily governed by the presence and type of vacant metal centers (i.e., Fe

  9. Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.

    Science.gov (United States)

    Kedzierski, Lukasz; Tate, Michelle D; Hsu, Alan C; Kolesnik, Tatiana B; Linossi, Edmond M; Dagley, Laura; Dong, Zhaoguang; Freeman, Sarah; Infusini, Giuseppe; Starkey, Malcolm R; Bird, Nicola L; Chatfield, Simon M; Babon, Jeffrey J; Huntington, Nicholas; Belz, Gabrielle; Webb, Andrew; Wark, Peter Ab; Nicola, Nicos A; Xu, Jianqing; Kedzierska, Katherine; Hansbro, Philip M; Nicholson, Sandra E

    2017-02-14

    Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5 -deficient mice exhibit heightened disease severity, with increased viral titres and weight loss. Socs5 levels were differentially regulated in response to distinct influenza viruses (H1N1, H3N2, H5N1 and H11N9) and were reduced in primary epithelial cells from COPD patients, again correlating with increased susceptibility to influenza. Importantly, restoration of SOCS5 levels restricted influenza virus infection, suggesting that manipulating SOCS5 expression and/or SOCS5 targets might be a novel therapeutic approach to influenza.

  10. Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS.

    Science.gov (United States)

    Wang, Tiehui; Gao, Qian; Nie, Pin; Secombes, Christopher J

    2010-10-01

    Four new members of the SOCS family of molecules in rainbow trout (Oncorhynchus mykiss), CISH and SOCS6, 7 and 9, are described for the first time in this species. The genes had a wide tissue distribution in trout, and were detected in gills, skin, muscle, liver, spleen, head kidney, intestine and brain, with brain having the highest expression levels. Stimulation of a rainbow trout leucocyte cell line, RTS-11, (mononuclear/macrophage-like cells) with LPS or Poly I:C had no effect on the expression of these genes, although in both cases the previously identified SOCS1-3 genes were up-regulated. Similarly, stimulation of RTS-11 or RTG-2 (fibroblasts) cells with the trout recombinant cytokines IFN-gamma or IL-1beta had no effect on CISH or SOCS6, 7 and 9 expression. However, PMA stimulation did impact on SOCS6 and SOCS9 expression, and LPS stimulation of primary cultures or bacterial infection (Yersinia ruckeri) increased significantly CISH expression (as well as SOCS1 and SOCS2 or SOCS3 respectively). It is apparent that the type II SOCS genes (CISH, SOCS1-3) are particularly relevant to immune regulation in fish, although the intriguing expansion of the SOCS4/5 subgroup in fish requires further investigation as to their role and functional divergence. Copyright 2010 Elsevier Ltd. All rights reserved.

  11. Medicago truncatula SOC1 Genes Are Up-regulated by Environmental Cues That Promote Flowering

    Directory of Open Access Journals (Sweden)

    Jared B. Fudge

    2018-04-01

    Full Text Available Like Arabidopsis thaliana, the flowering of the legume Medicago truncatula is promoted by long day (LD photoperiod and vernalization. However, there are differences in the molecular mechanisms involved, with orthologs of two key Arabidopsis thaliana regulators, FLOWERING LOCUS C (FLC and CONSTANS (CO, being absent or not having a role in flowering time function in Medicago. In Arabidopsis, the MADS-box transcription factor gene, SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (AtSOC1, plays a key role in integrating the photoperiodic and vernalization pathways. In this study, we set out to investigate whether the Medicago SOC1 genes play a role in regulating flowering time. Three Medicago SOC1 genes were identified and characterized (MtSOC1a–MtSOC1c. All three MtSOC1 genes, when heterologously expressed, were able to promote earlier flowering of the late-flowering Arabidopsis soc1-2 mutant. The three MtSOC1 genes have different patterns of expression. However, consistent with a potential role in flowering time regulation, all three MtSOC1 genes are expressed in the shoot apex and are up-regulated in the shoot apex of plants in response to LD photoperiods and vernalization. The up-regulation of MtSOC1 genes was reduced in Medicago fta1-1 mutants, indicating that they are downstream of MtFTa1. Insertion mutant alleles of Medicago soc1b do not flower late, suggestive of functional redundancy among Medicago SOC1 genes in promoting flowering.

  12. Purification of SOCS (Suppressor of Cytokine Signaling) SH2 Domains for Structural and Functional Studies.

    Science.gov (United States)

    Liau, Nicholas P D; Laktyushin, Artem; Babon, Jeffrey J

    2017-01-01

    Src Homology 2 (SH2) domains are protein domains which have a high binding affinity for specific amino acid sequences containing a phosphorylated tyrosine residue. The Suppressors of Cytokine Signaling (SOCS) proteins use an SH2 domain to bind to components of certain cytokine signaling pathways to downregulate the signaling cascade. The recombinantly produced SH2 domains of various SOCS proteins have been used to undertake structural and functional studies elucidating the method of how such targeting occurs. Here, we describe the protocol for the recombinant production and purification of SOCS SH2 domains, with an emphasis on SOCS3.

  13. An Overview and Comparison of Online Implementable SOC Estimation Methods for Lithium-ion Battery

    DEFF Research Database (Denmark)

    Meng, Jinhao; Ricco, Mattia; Luo, Guangzhao

    2018-01-01

    . Many SOC estimation methods have been proposed in the literature. However, only a few of them consider the real-time applicability. This paper reviews recently proposed online SOC estimation methods and classifies them into five categories. Their principal features are illustrated, and the main pros...... and cons are provided. The SOC estimation methods are compared and discussed in terms of accuracy, robustness, and computation burden. Afterward, as the most popular type of model based SOC estimation algorithms, seven nonlinear filters existing in literature are compared in terms of their accuracy...

  14. Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

    DEFF Research Database (Denmark)

    Greenhalgh, Christopher J; Metcalf, Donald; Thaus, Anne L

    2002-01-01

    Suppressor of cytokine signaling (SOCS)-2 is a member of a family of intracellular proteins implicated in the negative regulation of cytokine signaling. The generation of SOCS-2-deficient mice, which grow to one and a half times the size of their wild-type littermates, suggests that SOCS-2 may at...

  15. TARGETED ANALYSIS OF JAK-STAT-SOCS GENES IN DAIRY CATTLE

    Directory of Open Access Journals (Sweden)

    Arun Sondur Jayappa

    2015-12-01

    Full Text Available The Janus kinase and signal transducer and activator of transcription (JAK-STAT pathway genes along with suppressors of cytokine signalling (SOCS family genes play a crucial role in controlling cytokine signals in the mammary gland and thus mammary gland development. Mammary gene expression studies showed differential expression patterns for all the JAK-STAT pathway genes. Gene expression studies using qRT-PCR revealed differential expression of SOCS2, SOCS4 and SOCS5 genes across the lactation cycle in dairy cows. Using genotypes from 1,546 Australian Holstein- Friesian bulls, a statistical model based on SNPs within 500kb of JAK-STAT pathway genes, and SOCS genes alone was carried out. The analysis suggested that these genes and pathways make a significant contribution to the Australian milk production traits. Selection of 24 SNPs close to SOCS1, SOCS3, SOCS5, SOCS7 and CISH genes were significantly associated with, Australian Profit Ranking (APR, Australian Selection Index (ASI and protein yield (PY. This study supports the view that there may be some merit in choosing SNPs around functionally relevant genes for the selection and genetic improvement schemes for dairy production traits.

  16. IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever

    Directory of Open Access Journals (Sweden)

    Lilian Karem Flores-Mendoza

    2017-01-01

    Full Text Available Background. Cytokines play important roles in the physiopathology of dengue infection; therefore, the suppressors of cytokine signaling (socs that control the type and timing of cytokine functions could be involved in the origin of immune alterations in dengue. Objective. To explore the association of cytokine and socs levels with disease severity in dengue patients. Methods. Blood samples of 48 patients with confirmed dengue infection were analyzed. Amounts of interleukins IL-2, IL-4, IL-6, and IL-10, interferon- (IFN- γ, and tumor necrosis factor- (TNF- α were quantified by flow cytometry, and the relative expression of socs1 and socs3 mRNA was quantified by real-time RT-PCR. Results. Increased levels of IL-10 and socs3 and lower expression of socs1 were found in patients with dengue hemorrhagic fever (DHF with respect to those with dengue fever (DF (p199.8-fold, socs1 (134 pg/ml have the highest sensitivity and specificity to discriminate between DF and DHF. Conclusion. Simultaneous changes in IL-10 and socs1/socs3 could be used as prognostic biomarkers of dengue severity.

  17. Favorable prognostic value of SOCS2 and IGF-I in breast cancer

    International Nuclear Information System (INIS)

    Haffner, Michael C; Petridou, Barbara; Peyrat, Jean Phillipe; Révillion, Françoise; Müller-Holzner, Elisabeth; Daxenbichler, Günter; Marth, Christian; Doppler, Wolfgang

    2007-01-01

    Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer. We determined the mRNA expression levels of SOCS1, SOCS2, SOCS3, CIS and IGF-I in 89 primary breast cancers by reverse transcriptase PCR. SOCS2 protein expression was further evaluated by immuno-blot and immunohistochemistry. SOCS2 expression inversely correlated with histopathological grade and ER positive tumors exhibited higher SOCS2 levels. Patients with high SOCS2 expression lived significantly longer (108.7 vs. 77.7 months; P = 0.015) and high SOCS2 expression proved to be an independent predictor for good prognosis (HR = 0.45, 95% CI 0.23 – 0.91, P = 0.026). In analogy to SOCS2, high IGF-I expression was an independent predictor for good prognosis in the entire patient cohort. In the subgroup of patients with lymph-node negative disease, high IGF-I was a strong predictor for favorable outcome in terms of overall survival and relapse free survival (HR = 0.075, 95% CI 0.014 – 0.388, P = 0.002). This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. Furthermore a strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. Our results suggest that high expression of the STAT5 target genes SOCS2 and IGF-I is a feature of differentiated and less malignant tumors

  18. Favorable prognostic value of SOCS2 and IGF-I in breast cancer

    Directory of Open Access Journals (Sweden)

    Daxenbichler Günter

    2007-07-01

    Full Text Available Abstract Background Suppressor of cytokine signaling (SOCS proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer. Methods We determined the mRNA expression levels of SOCS1, SOCS2, SOCS3, CIS and IGF-I in 89 primary breast cancers by reverse transcriptase PCR. SOCS2 protein expression was further evaluated by immuno-blot and immunohistochemistry. Results SOCS2 expression inversely correlated with histopathological grade and ER positive tumors exhibited higher SOCS2 levels. Patients with high SOCS2 expression lived significantly longer (108.7 vs. 77.7 months; P = 0.015 and high SOCS2 expression proved to be an independent predictor for good prognosis (HR = 0.45, 95% CI 0.23 – 0.91, P = 0.026. In analogy to SOCS2, high IGF-I expression was an independent predictor for good prognosis in the entire patient cohort. In the subgroup of patients with lymph-node negative disease, high IGF-I was a strong predictor for favorable outcome in terms of overall survival and relapse free survival (HR = 0.075, 95% CI 0.014 – 0.388, P = 0.002. Conclusion This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. Furthermore a strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. Our results suggest that high expression of the STAT5 target genes SOCS2 and IGF

  19. Fish Suppressors of Cytokine Signaling (SOCS): Gene Discovery, Modulation of Expression and Function

    Science.gov (United States)

    Wang, Tiehui; Gorgoglione, Bartolomeo; Maehr, Tanja; Holland, Jason W.; Vecino, Jose L. González; Wadsworth, Simon; Secombes, Christopher J.

    2011-01-01

    The intracellular suppressors of cytokine signaling (SOCS) family members, including CISH and SOCS1 to 7 in mammals, are important regulators of cytokine signaling pathways. So far, the orthologues of all the eight mammalian SOCS members have been identified in fish, with several of them having multiple copies. Whilst fish CISH, SOCS3, and SOCS5 paralogues are possibly the result of the fish-specific whole genome duplication event, gene duplication or lineage-specific genome duplication may also contribute to some paralogues, as with the three trout SOCS2s and three zebrafish SOCS5s. Fish SOCS genes are broadly expressed and also show species-specific expression patterns. They can be upregulated by cytokines, such as IFN-γ, TNF-α, IL-1β, IL-6, and IL-21, by immune stimulants such as LPS, poly I:C, and PMA, as well as by viral, bacterial, and parasitic infections in member- and species-dependent manners. Initial functional studies demonstrate conserved mechanisms of fish SOCS action via JAK/STAT pathways. PMID:22203897

  20. SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice

    DEFF Research Database (Denmark)

    Zadjali, Fahad; Santana-Farre, Ruyman; Vesterlund, Mattias

    2012-01-01

    in the development of diet-induced hepatic steatosis and insulin resistance. SOCS2-knockout (SOCS2(-/-)) mice and wild-type littermates were fed for 4 mo with control or high-fat diet, followed by assessment of insulin sensitivity, hepatic lipid content, and expression of inflammatory cytokines. SOCS2(-/-) mice...

  1. Correct-by-construction approaches for SoC design

    CERN Document Server

    Sinha, Roopak; Basu, Samik

    2013-01-01

    This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components.

  2. Effect of SOCS1 overexpression on RPE cell activation by proinflammatory cytokines.

    Science.gov (United States)

    Bazewicz, Magdalena; Draganova, Dafina; Makhoul, Maya; Chtarto, Abdel; Elmaleh, Valerie; Tenenbaum, Liliane; Caspers, Laure; Bruyns, Catherine; Willermain, François

    2016-09-06

    The purpose of this study was to investigate the in vitro effect of Suppressor Of Cytokine Signaling 1 (SOCS1) overexpression in retinal pigment epithelium (RPE) cells on their activation by pro-inflammatory cytokines IFNγ, TNFα and IL-17. Retinal pigment epithelium cells (ARPE-19) were stably transfected with the control plasmid pIRES2-AcGFP1 or the plasmid pSOCS1-IRES2-AcGFP1. They were stimulated by IFNγ (150ng/ml), TNFα (30ng/ml) or IL-17 (100ng/ml). The levels of SOCS1 mRNA were measured by real-time PCR. Signal Transducer and Activator of Transcription 1 (STAT1) phosphorylation and IκBα expression were analysed by western Blot (WB). IL-8 secretion was analysed by ELISA and expression of MHCII molecules and ICAM-1/CD54 by flow cytometry. Our data show that SOCS1 mRNA overexpression in RPE cells prevents IFNγ-induced SOCS1 mRNA increase and IFNγ-mediated STAT1 phosphorylation. Moreover, SOCS1 overexpression in RPE cells inhibits IFNγ-induced decrease of IL-8 secretion and prevents IFNγ-induced MHC II and ICAM1/CD54 upregulation. However, SOCS1 overexpression does not affect TNFα-induced IκBα degradation nor block TNFα-induced or IL-17-induced IL-8 secretion. On the contrary, IL-17-induced secretion is increased by SOCS1 overexpression. In conclusion, SOCS1 overexpression in RPE cells inhibits some IFNγ-mediated responses that lead to uveitis development. This notion raises the possibility that SOCS1 overexpression could be a novel target for treating non-infectious uveitis. However, some proinflammatory effects of TNFα and IL-17 stimulation on RPE are not blocked by SOCS1 overexpression. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  3. Boosted gain programmable OpAmp with embedded gain monitor for dependable SoCs

    NARCIS (Netherlands)

    Wan, J.; Kerkhoff, Hans G.

    2011-01-01

    SoCs used in safety-critical applications need to be dependable. However in the deep-submicron region, different kinds of aging effects like negative bias temperature instability (NBTI) make the SoCs, especially the analog/mixed-signal parts, undependable. In this paper, a dependability-improved

  4. Defective interleukin-4/Stat6 activity correlates with increased constitutive expression of negative regulators SOCS-3, SOCS-7, and CISH in colon cancer cells.

    Science.gov (United States)

    Liu, Xiao Hong; Xu, Shuang Bing; Yuan, Jia; Li, Ben Hui; Zhang, Yan; Yuan, Qin; Li, Pin Dong; Li, Feng; Zhang, Wen Jie

    2009-12-01

    Interleukin-4 (IL-4)-induced Stat6 activities (phenotypes) vary among human cancer cells, of which the HT-29 cell line carries an active Stat6(high) phenotype, while Caco-2 carries a defective Stat6(null) phenotype, respectively. Cancer cells with Stat6(high) show resistance to apoptosis and exaggerated metastasis, suggesting the clinical significance of Stat6 phenotypes. We previously showed that Stat6(high) HT-29 cells exhibited low constitutive expression of Stat6-negative regulators SOCS-1 and SHP-1 because of gene hypermethylation. This study further examined the constitutive expression of other closely related SOCS family numbers including SOCS-3, SOCS-5, SOCS-7, and CISH using RT-PCR. Similar to SOCS-1 and SHP-1, Stat6(high) HT-29 cells expressed low constitutive mRNA of SOCS-3, SOCS-7, and CISH than Stat6(null) Caco-2 cells. Interestingly, DNA demethylation using 5-aza-2'-deoxycytidine in HT-29 cells up-regulated mRNA expression of the above genes, indicating a hypermethylation status, which was confirmed by methylation-specific sequencing in selected SOCS-3 gene. Furthermore, defective Stat6(null) Caco-2 exhibited impaired phosphorylation of Stat6 after IL-4 stimulation by flow cytometry, in keeping with the notion of an over-performed negative regulation. The findings that IL-4/Stat6 phenotypes show differential expression of multiple negative regulators suggest a model that a collective force of powerful negative regulators, directly and indirectly, acts on Stat6 activation, which may result in differential Stat6 phenotypes.

  5. Over-expression of KdSOC1 gene affected plantlet morphogenesis in Kalanchoe daigremontiana.

    Science.gov (United States)

    Zhu, Chen; Wang, Li; Chen, Jinhua; Liu, Chenglan; Zeng, Huiming; Wang, Huafang

    2017-07-17

    Kalanchoe daigremontiana reproduces asexually by producing plantlets along the leaf margin. The aim of this study was to identify the function of the SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 gene in Kalanchoe daigremontiana (KdSOC1) during plantlet morphogenesis. In this study, KdSOC1 gene expression was detected at stem cell niche during in vitro somatic embryogenesis and plantlet morphogenesis. Disrupting endogenous auxin transportation suppressed the KdSOC1 gene response. Knockdown of the KdSOC1 gene caused a defect in cotyledon formation during the early heart stage of somatic embryogenesis. Over-expression (OE) of the KdSOC1 gene resulted in asymmetric plantlet distribution, a reduced number of plantlets, thicker leaves, and thicker vascular fibers. Higher KdPIN1 gene expression and auxin content were found in OE plant compared to those of wild-type plant leaves, which indicated possible KdSOC1 gene role in affecting auxin distribution and accumulation. KdSOC1 gene OE in DR5-GUS Arabidopsis reporting lines resulted in an abnormal auxin response pattern during different stages of somatic embryogenesis. In summary, the KdSOC1 gene OE might alter auxin distribution and accumulation along leaf margin to initiate plantlet formation and distribution, which is crucial for plasticity during plantlet formation under various environmental conditions.

  6. Process modeling of a reversible solid oxide cell (r-SOC) energy storage system utilizing commercially available SOC reactor

    International Nuclear Information System (INIS)

    Mottaghizadeh, Pegah; Santhanam, Srikanth; Heddrich, Marc P.; Friedrich, K. Andreas; Rinaldi, Fabio

    2017-01-01

    Highlights: • An electric energy storage system was developed based on a commercially available SOC reactor. • Heat generated in SOFC mode of r-SOC is utilized in SOEC operation of r-SOC using latent heat storage. • A round trip efficiency of 54.3% was reached for the reference system at atmospheric pressure. • An improved process system design achieved a round-trip efficiency of 60.4% at 25 bar. - Abstract: The increase of intermittent renewable energy contribution in power grids has urged us to seek means for temporal decoupling of electricity production and consumption. A reversible solid oxide cell (r-SOC) enables storage of surplus electricity through electrochemical reactions when it is in electrolysis mode. The reserved energy in form of chemical compounds is then converted to electricity when the cell operates as a fuel cell. A process system model was implemented using Aspen Plus® V8.8 based on a commercially available r-SOC reactor experimentally characterized at DLR. In this study a complete self-sustaining system configuration is designed by optimal thermal integration and balance of plant. Under reference conditions a round trip efficiency of 54.3% was achieved. Generated heat in fuel cell mode is exploited by latent heat storage tanks to enable endothermic operation of reactor in its electrolysis mode. In total, out of 100 units of thermal energy stored in heat storage tanks during fuel cell mode, 90% was utilized to offset heat demand of system in its electrolysis mode. Parametric analysis revealed the significance of heat storage tanks in thermal management even when reactor entered its exothermic mode of electrolysis. An improved process system design demonstrates a system round-trip efficiency of 60.4% at 25 bar.

  7. Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells.

    Science.gov (United States)

    Takahashi, Yuki; Kaneda, Haruka; Takasuka, Nana; Hattori, Kayoko; Nishikawa, Makiya; Watanabe, Yoshihiko; Takakura, Yoshinobu

    2008-08-01

    The suppressor of cytokine signaling (SOCS) proteins, negative regulators of interferon (IFN)-induced signaling pathways, is involved in IFN resistance of tumor cells. To improve the growth inhibitory effect of IFN-beta and IFN-gamma on a murine melanoma cell line, B16-BL6, and a murine colon carcinoma cell line, Colon26 cells, SOCS-1 and SOCS-3 gene expression in tumor cells was downregulated by transfection of plasmid DNA expressing short hairpin RNA targeting one of these genes (pshSOCS-1 and pshSOCS-3, respectively). Transfection of pshSOCS-1 significantly increased the antiproliferative effect of IFN-gamma on B16-BL6 cells. However, any other combinations of plasmids and IFN had little effect on the growth of B16-BL6 cells. In addition, transfection of pshSOCS-1 and pshSOCS-3 produced little improvement in the effect of IFN on Colon26 cells. To understand the mechanism underlining these findings, the level of SOCS gene expression was measured by real time polymerase chain reaction. Addition of IFN-gamma greatly increased the SOCS-1 mRNA expression in B16-BL6 cells. Taking into account the synergistic effect of pshSOCS-1 and IFN-gamma on the growth of B16-BL6 cells, these findings suggest that IFN-gamma-induced high SOCS-1 gene expression in B16-BL6 cells significantly interferes with the antiproliferative effect of IFN-gamma. These results indicate that silencing SOCS gene expression can be an effective strategy to enhance the antitumor effect of IFN under conditions in which the SOCS gene expression is upregulated by IFN.

  8. Synthesis of highly monodispersed Ga-soc-MOF hollow cubes, colloidosomes and nanocomposites

    KAUST Repository

    Cai, Xuechao

    2016-07-06

    Ga-soc-MOF hollow cubes with an average size of about 300 nm were prepared by a polyvinylpyrrolidone (PVP) assisted acid etching process. Colloidosomes with sizes of around 5-10 mu m composed of single-layer tetrakaidecahedron building blocks (BBs) were synthesized for the first time. Au@Ga-soc-MOF nanocomposites with excellent catalytic properties were obtained.

  9. Synthesis of highly monodispersed Ga-soc-MOF hollow cubes, colloidosomes and nanocomposites

    KAUST Repository

    Cai, Xuechao; Deng, Xiaoran; Xie, Zhongxi; Bao, Shouxin; Shi, Yanshu; Lin, Jun; Pang, Maolin; Eddaoudi, Mohamed

    2016-01-01

    Ga-soc-MOF hollow cubes with an average size of about 300 nm were prepared by a polyvinylpyrrolidone (PVP) assisted acid etching process. Colloidosomes with sizes of around 5-10 mu m composed of single-layer tetrakaidecahedron building blocks (BBs) were synthesized for the first time. Au@Ga-soc-MOF nanocomposites with excellent catalytic properties were obtained.

  10. SPAD array based TOF SoC design for unmanned vehicle

    Science.gov (United States)

    Pan, An; Xu, Yuan; Xie, Gang; Huang, Zhiyu; Zheng, Yanghao; Shi, Weiwei

    2018-03-01

    As for the requirement of unmanned-vehicle mobile Lidar system, this paper presents a SoC design based on pulsed TOF depth image sensor. This SoC has a detection range of 300m and detecting resolution of 1.5cm. Pixels are made of SPAD. Meanwhile, SoC adopts a structure of multi-pixel sharing TDC, which significantly reduces chip area and improve the fill factor of light-sensing surface area. SoC integrates a TCSPC module to achieve the functionality of receiving each photon, measuring photon flight time and processing depth information in one chip. The SOC is designed in the SMIC 0.13μm CIS CMOS technology

  11. Impact of vegetation types on soil organic carbon stocks SOC-S in Mediterranean natural areas

    Science.gov (United States)

    Parras-Alcántara, Luis; Lozano-García, Beatriz; Cantudo-Pérez, Marta

    2015-04-01

    Soils play a key role in the carbon geochemical cycle because they can either emit large quantities of CO2 or on the contrary they can act as a store for carbon. Agriculture and forestry are the only activities that can achieve this effect through photosynthesis and the carbon incorporation into carbohydrates (Parras-Alcántara et al., 2013). The Mediterranean evergreen oak Woodland (MEOW - dehesa) is a type of pasture with scattered evergreen and deciduous oak stands in which cereals are often grown under the tree cover. It is a system dedicated to the combined production of Iberian swine, sheep, fuel wood, coal and cork as well as to hunting. These semi-natural areas still preserve some of the primitive vegetation of the Mediterranean oak forests. The dehesa is a pasture where the herbaceous layer is comprised of either cultivated cereals such as oat, barley and wheat or native vegetation dominated by annual species, which are used as grazing resources. These Iberian open woodland rangelands (dehesas) have been studied from different points of view: hydrologically, with respect to soil organic matter content, as well as in relation to gully erosion, topographical thresholds, soil erosion and runoff production, soil degradation and management practices…etc, among others. The soil organic carbon stock capacity depends not only on abiotic factors such as the mineralogical composition and the climate, but also on soil use and management (Parras et al., 2014 and 2015). In Spanish soils, climate, use and management strongly affect the carbon variability, mainly in soils in dry Mediterranean climates characterized by low organic carbon content, weak structure and readily degradable soils. Hontoria et al. (2004) emphasized that the climate and soil use are two factors that greatly influence carbon content in the Mediterranean climate. This research sought to analyze the SOC stock (SOCS) variability in MEOW - dehesa with cereals, olive grove and Mediterranean oak forest

  12. Comments on ''The optimization of electronic precision in ultrasonic velocity measurements: A comparison of the time interval averaging and sing around methods'' [J. Acoust. Soc. Am. 73, 1833--1837 (1983)

    International Nuclear Information System (INIS)

    Karplus, H.B.

    1984-01-01

    J. D. Aindow and R. C. Chivers [J. Acoust. Soc. Am. 73, 1833 (1983)] compared the precision of the direct ''time-of-flight'' technique with the ''sing-around'' method for sound velocity measurement. Their conclusion is changed by the newer, faster, commercial clocks (2 ns HP5345<0.1 ns HP5370), giving the advantage to the time of flight method. The analysis is herewith augmented by calculating the time jitter in terms of signal to noise ratio, which was correctly shown to be negligible with 100-ns clocks, but becomes increasingly more significant with faster clocks

  13. Cache Performance Optimization for SoC Vedio Applications

    OpenAIRE

    Lei Li; Wei Zhang; HuiYao An; Xing Zhang; HuaiQi Zhu

    2014-01-01

    Chip Multiprocessors (CMPs) are adopted by industry to deal with the speed limit of the single-processor. But memory access has become the bottleneck of the performance, especially in multimedia applications. In this paper, a set of management policies is proposed to improve the cache performance for a SoC platform of video application. By analyzing the behavior of Vedio Engine, the memory-friendly writeback and efficient prefetch policies are adopted. The experiment platform is simulated by ...

  14. SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control

    DEFF Research Database (Denmark)

    Reddy, P.N.G.; Serve, H.; Brandts, C.H.

    2012-01-01

    Activating mutations in the receptor tyrosine kinase FLT3 are frequently found in acute myelogenous leukemia patients and confer poor clinical prognosis. It is unclear how leukemic blasts escape cytokine control that regulates normal hematopoiesis. We have recently demonstrated that FLT3-internal...

  15. Key KdSOC1 gene expression profiles during plantlet morphogenesis under hormone, photoperiod, and drought treatments.

    Science.gov (United States)

    Liu, C; Zhu, C; Zeng, H M

    2016-02-11

    Kalanchoe daigremontiana utilizes plantlet formation between its zigzag leaf margins as its method of asexual reproduction. In this study, K. daigremontiana SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (KdSOC1), a key intermediate in the transition from vegetative to asexual growth, was cloned. Furthermore, its expression profiles during plantlet formation under different environmental and hormone induction conditions were analyzed. The full-KdSOC1 cDNA sequence length was 1410 bp with 70% shared homology with Carya cathayensis SOC1. The conserved domain search of KdSOC1 showed the absence of I and C domains, which might indicate novel biological functions in K. daigremontiana. The full-KdSOC1 promoter sequence was 1401 bp long and contained multiple-hormone-responsive cis-acting elements. Hormone induction assays showed that gibberellins and salicylic acid mainly regulated KdSOC1 expression. The swift change from low to high KdSOC1 expression levels during long-day induction was accompanied by the rapid emergence of plantlets. Drought stress stimulated KdSOC1 expression in leaves both with and without plantlet formation. Together, the results suggested that KdSOC1 was closely involved in environmental stimulation signal perception and the transduction of K. daigremontiana plantlet formation. Therefore, future identification of KdSOC1 functions might reveal key information that will help elucidate the transition network between embryogenesis and organogenesis during plantlet formation.

  16. A microprocessor from AVR to embedded SoC

    International Nuclear Information System (INIS)

    Jeong, Geum Seoh

    2005-01-01

    This book was divided into two parts. The first part consists of ten chapter, which are basic knowledge, code vision AVR compiler, analysis on code vision, introduction and characteristic of AVR, I/O ports, interrupt and timer/counter, LCD, serial communication, analog comparator and stepping Motor and digital control of DC Motor. In the second part, it introduces Embedded Soc including application field, its characteristic, general description, functional description, designs with Quartus II.

  17. A multiscale framework with extended Kalman filter for lithium-ion battery SOC and capacity estimation

    International Nuclear Information System (INIS)

    Hu, Chao; Youn, Byeng D.; Chung, Jaesik

    2012-01-01

    Highlights: ► We develop a mutiscale framework with EKF to estimate SOC and capacity. ► The framework is a hybrid of coulomb counting and adaptive filtering techniques. ► It decouples SOC and capacity estimation in terms of measurement and time-scale. ► Results verify the framework achieves higher accuracy and efficiency than dual EKF. -- Abstract: State-of-charge (SOC) and capacity estimation plays an essential role in many battery-powered applications, such as electric vehicle (EV) and hybrid electric vehicle (HEV). However, commonly used joint/dual extended Kalman filter (EKF) suffers from the lack of accuracy in the capacity estimation since (i) the cell voltage is the only measurable data for the SOC and capacity estimation and updates and (ii) the capacity is very weakly linked to the cell voltage. The lack of accuracy in the capacity estimation may further reduce the accuracy in the SOC estimation due to the strong dependency of the SOC on the capacity. Furthermore, although the capacity is a slowly time-varying quantity that indicates cell state-of-health (SOH), the capacity estimation is generally performed on the same time-scale as the quickly time-varying SOC, resulting in high computational complexity. To resolve these difficulties, this paper proposes a multiscale framework with EKF for SOC and capacity estimation. The proposed framework comprises two ideas: (i) a multiscale framework to estimate SOC and capacity that exhibit time-scale separation and (ii) a state projection scheme for accurate and stable capacity estimation. Simulation results with synthetic data based on a valid cell dynamic model suggest that the proposed framework, as a hybrid of coulomb counting and adaptive filtering techniques, achieves higher accuracy and efficiency than joint/dual EKF. Results of the cycle test on Lithium-ion prismatic cells further verify the effectiveness of our framework.

  18. Damage evolution during actuation fatigue in shape memory alloys (SPIE Best Student Paper Award)

    Science.gov (United States)

    Phillips, Francis R.; Wheeler, Robert; Lagoudas, Dimitris C.

    2018-03-01

    Shape Memory Alloys (SMAs) are unique materials able to undergo a thermomechanically induced, reversible phase transformation. Additionally, SMA are subject to two types of fatigue, that is structural fatigue due to cyclic loading as experienced by most materials, as well as actuation fatigue due to repeated thermally induced phase transformation. The evolution of multiple material characteristics is presented over the actuation fatigue lifetime of NiTiHf actuators, including the accumulation of irrecoverable strain, the evolution of internal voids, and the evolution of the effective modulus of the actuator. The results indicate that all three of these material characteristics are clearly interconnected and careful analysis of each of these characteristics can help to understand the evolution of the others, as well as help to understand how actuation fatigue leads to ultimate failure of the actuator.

  19. Mapping the variation of soil organic carbon (SOC) stock in time and space in Sicily, an extremely variable semi-arid Mediterranean region, highlighted that C was lost in area rich in organic C and gained in poor-C areas

    Science.gov (United States)

    Schillaci, Calogero; Acutis, Marco; Lombardo, Luigi; Lipani, Aldo; Fantappiè, Maria; Märker, Michael; Saia, Sergio

    2017-04-01

    The stock of organic carbon in the soil (SOC) is an indicator of soil ability to support agro-ecosystems productivity and resilience to environmental changes (Schillaci et al. 2016; 2017). In addition, SOC stock change through space and especially time is a valuable indicator of the soil ability to sequester CO2 from the atmosphere and thus its potential to reduce the greenhouse gas effect. In the present work, we mapped (1-km resolution) the space-time variation of the SOC stock after 15 years (1993 to 2008) in a semi-arid Mediterranean area (25,286 km2) after modelling SOC concentration (0-0.4 m depth) with boosted regression trees (BRT) and computing the SOC stock after the application of the bulk density maps of ISRIC (soilgrid.com, Hengl et al., 2014). The area under study (Sicily, south of Italy) has a plenty of contrasting environments, with changing ecosystems, soils, and microclimatic regions. The BRT procedure was run with a set of 25 predictors per year, including land use, soil traits, morphometric indicators and remote sensing covariates (derived from Landsat5 data). The BRT output consisted of a high pseudo-R2(=0.71 for 1993 and 0.63 for 2008) of the SOC concentration, low uncertainty (standard deviation doi:10.1016/j.geoderma.2016.10.

  20. Research on State-of-Charge (SOC) estimation using current integration based on temperature compensation

    Science.gov (United States)

    Yin, J.; Shen, Y.; Liu, X. T.; Zeng, G. J.; Liu, D. C.

    2017-11-01

    The traditional current integral method for the state-of-charge (SOC) estimation has an unusable estimation accuracy because of the current measuring error. This paper proposed a closed-loop temperature compensation method to improve the SOC estimation accuracy of current integral method by eliminating temperature drift. Through circuit simulation result in Multisim, the stability of current measuring accuracy is improved by more than 10 times. In a designed 70 charge-discharge experimental circle, the SOC estimation error with temperature compensation had 30 times less than error in normal situation without compensation.

  1. Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice

    DEFF Research Database (Denmark)

    Alkharusi, Amira; Mirecki-Garrido, Mercedes; Ma, Zuheng

    2016-01-01

    Background: Diabetes type 1 is characterized by the failure of beta cells to produce insulin. Suppressor of cytokine signaling (SOCS) proteins are important regulators of the Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway. Previous studies have shown that GH can...... prevent the development of type I diabetes in mice and that SOCS2 deficiency mimics a state of increased GH sensitivity. Methodology: The elevated sensitivity of SOCS2-/- mice to GH and possibly to PRL was the rationale to analyze the effects of multiple low dose streptozotocin (MLDSTZ)-induced diabetes...... in SOCS2-/- mice. Results: We show that 6-month-old SOCS2-/- mice, but not 2-month-old mice, were less sensitive to MLDSTZ-induced diabetes, compared to controls. MLDSTZ treatment induced glucose intolerance in both SOCS2+/+ and SOCS2-/- mice, as shown by glucose tolerance tests, with SOCS2+/+ mice...

  2. Mapping SOC in a river catchment by integrating laboratory spectra wavelength with remote sensing spectra

    DEFF Research Database (Denmark)

    Peng, Yi; Xiong, Xiong; Knadel, Maria

    There is potential to use soil ·-proximal and remote sensing derived spectra concomitantly to develop soil organic carbon (SOC) models. Yet mixing spectral data from different sources and technologies to improve soil models is still in its infancy. The objective of this study was to incorporate...... soil spectral features indicative of SOC from laboratory visible near-infrared reflectance (vis-NlR) spectra and incorporate them with remote sensing (RS) images to improve predictions of top SOC in the Skjem river catchment, Denmark. The secondary objective was to improve prediction results...

  3. Die verdonkerende spieël: Simbolistiese trekke in Wilma Stockenstrom se eerste drie bundels

    Directory of Open Access Journals (Sweden)

    M. Lombard

    1993-05-01

    Full Text Available This article is an attempt to relate the first three of Wilma Stockenstrom's collections of poetry to international Symbolism. First we discuss possible links between her work and Symbolism. The mam emphasis then falls on Stockenstrom’s method of Symbolism, the possible symbolist tone of her work and prominent symbolist motifs in her work. Finally we consider some manifestations of the symbolist oilier world in these collections. The conclusion arrived at is that Stockenstrom's earlier work shows many of the main characteristics of Symbolism so that her work can be regarded as a continuation of the symbolist tradition. This tradition undergoes three important transformations in her work: the European world of symbolist poetry is replaced by an archeologically rich but mute African world, modern science and technology replaces the medieval system of reference of Symbolism, and sound and musicality p la y a much smaller part in Stockenstrom's poetry. Stockenstrom's cynical, ironic tone, the use of opaque kafkaesque symbols, her emphasis on tentative visions, her distrust of language and her tendency to relativize frames of reference in the endings of her poems, show that Stockenstrom's poetry has already crossed the boundary to Modernism.

  4. A new circuit for at-speed scan SoC testing

    International Nuclear Information System (INIS)

    Lin Wei; Shi Wenlong

    2013-01-01

    It is very important to detect transition-delay faults and stuck-at faults in system on chip (SoC) under 90 nm processing technology, and the transition-delay faults can only be detected by using an at-speed testing method. In this paper, an on-chip clock (OCC) controller with a bypass function based on an internal phase-locked loop is designed to test faults in SoC. Furthermore, a clock chain logic which can eliminate the metastable state is realized to generate an enable signal for the OCC controller, and then, the test pattern is generated by automatic test pattern generation (ATPG) tools. Next, the scan test pattern is simulated by using the Synopsys tool and the correctness of the design is verified. The result shows that the design of an at-speed scan test in this paper is highly efficient for detecting timing-related defects. Finally, the 89.29% transition-delay fault coverage and the 94.50% stuck-at fault coverage are achieved, and it is successfully applied to an integrated circuit design. (semiconductor integrated circuits)

  5. Kepler: A Search for Terrestrial Planets - SOC 9.3 DR25 Pipeline Parameter Configuration Reports

    Science.gov (United States)

    Campbell, Jennifer R.

    2017-01-01

    This document describes the manner in which the pipeline and algorithm parameters for the Kepler Science Operations Center (SOC) science data processing pipeline were managed. This document is intended for scientists and software developers who wish to better understand the software design for the final Kepler codebase (SOC 9.3) and the effect of the software parameters on the Data Release (DR) 25 archival products.

  6. A step toward 'plug and play' robotics with SoC technology

    DEFF Research Database (Denmark)

    Sørensen, Anders Stengaard; Falsig, Simon; Ugilt, Rolf

    p, li { white-space: pre-wrap; } This article describe our progress toward simplifying and streamlining the low level systems integration of experimental robots, combining a System on Chip (SoC) approach with conventional modular approaches. The combined approach has increased flexibility, improved...... the embedded integration, and decreased the complexity of programming, compared to conventional modular approaches. We show the impact of the SoC approach in a simple demonstration and teaching model of a walking robot....

  7. Space Operations Center system analysis. Volume 3, book 2: SOC system definition report, revision A

    Science.gov (United States)

    1982-01-01

    The Space Operations Center (SOC) orbital space station program operations are described. A work breakdown structure for the general purpose support equipment, construction and transportation support, and resupply and logistics support systems is given. The basis for the design of each element is presented, and a mass estimate for each element supplied. The SOC build-up operation, construction, flight support, and satellite servicing operations are described. Detailed programmatics and cost analysis are presented.

  8. Synergy of SOCS-1 Inhibition and Microbial-Based Cancer Vaccines

    Science.gov (United States)

    2013-09-01

    SH2 domain; a docking motif for interaction with tyrosine...IL‐ 4, IL‐7, IL‐15), IFN‐α, IFN‐γ, and IL‐12. While the SH2 domain targets the SOCS proteins to specific molecules within the JAK‐ STAT pathway, the...SOCS‐box functions as an E3 ubiquitin ligase, promoting degradation of the cytokine receptor complex. SOCS1 also contains a kinase inhibitory

  9. Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

    DEFF Research Database (Denmark)

    Beck Jørgensen, Sebastian; O'Neill, Hayley M; Sylow, Lykke

    2013-01-01

    Obesity is associated with chronic low-grade inflammation that contributes to defects in energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 expression is increased in skeletal muscle of obese humans. SOCS3 inhibits leptin signaling in the hypothalamus and insulin...... of hyperinsulinemia and insulin resistance because of enhanced skeletal muscle insulin receptor substrate 1 (IRS1) and Akt phosphorylation that resulted in increased skeletal muscle glucose uptake. These data indicate that skeletal muscle SOCS3 does not play a critical role in regulating muscle development or energy...... expenditure, but it is an important contributing factor for inhibiting insulin sensitivity in obesity. Therapies aimed at inhibiting SOCS3 in skeletal muscle may be effective in reversing obesity-related glucose intolerance and insulin resistance....

  10. The Internal Audit Outsourcing

    Directory of Open Access Journals (Sweden)

    Grzegorz Gołębiowski

    2010-06-01

    Full Text Available The article explores an issue of the internal audit outsourcing. It indicates the differences between internal audit, outsourcing and cosourcing of this service as well as their advantages and disadvantages. Drawing from the research on internal audit outsourcing the recent market trends were identified as well as motivations for choosing different forms of internal auditing.

  11. The relationship between internalized stigma and quality of life among people with mental illness: are self-esteem and sense of coherence sequential mediators?

    Science.gov (United States)

    Świtaj, Piotr; Grygiel, Paweł; Chrostek, Anna; Nowak, Izabela; Wciórka, Jacek; Anczewska, Marta

    2017-09-01

    To elucidate the mechanism through which internalized stigma reduces the quality of life (QoL) of people with mental illness by exploring the mediating roles of self-esteem and sense of coherence (SOC). A cross-sectional analysis of 229 patients diagnosed with schizophrenia or affective disorders was undertaken to test a sequential mediation model assuming that more severe internalized stigma is related to lower self-esteem, which is associated with weaker SOC, which in turn relates to worse QoL. The proposed model was supported by the data. A sequential indirect effect from internalized stigma to QoL via self-esteem and SOC turned out to be significant [beta = -0.06, SE = 0.02; 95% CI (-0.11, -0.03)]. Support was also found for simple mediation models with either self-esteem or SOC as single mediators between internalized stigma and QoL. Self-esteem and SOC are personal resources that should be considered as potential targets of interventions aiming to prevent the harmful consequences of internalized stigma for the QoL of people receiving psychiatric treatment.

  12. SOCS proteins in regulation of receptor tyrosine kinase signaling

    DEFF Research Database (Denmark)

    Kazi, Julhash U.; Kabir, Nuzhat N.; Flores Morales, Amilcar

    2014-01-01

    Receptor tyrosine kinases (RTKs) are a family of cell surface receptors that play critical roles in signal transduction from extracellular stimuli. Many in this family of kinases are overexpressed or mutated in human malignancies and thus became an attractive drug target for cancer treatment....... The signaling mediated by RTKs must be tightly regulated by interacting proteins including protein-tyrosine phosphatases and ubiquitin ligases. The suppressors of cytokine signaling (SOCS) family proteins are well-known negative regulators of cytokine receptors signaling consisting of eight structurally similar...

  13. The International Criminal Court

    DEFF Research Database (Denmark)

    Damgaard, Ciara Therése

    This article considers whether acts of international terrorism can and should be prosecuted before the International Criminal Court as crimes against humanity.......This article considers whether acts of international terrorism can and should be prosecuted before the International Criminal Court as crimes against humanity....

  14. Robustness of SOC Estimation Algorithms for EV Lithium-Ion Batteries against Modeling Errors and Measurement Noise

    Directory of Open Access Journals (Sweden)

    Xue Li

    2015-01-01

    Full Text Available State of charge (SOC is one of the most important parameters in battery management system (BMS. There are numerous algorithms for SOC estimation, mostly of model-based observer/filter types such as Kalman filters, closed-loop observers, and robust observers. Modeling errors and measurement noises have critical impact on accuracy of SOC estimation in these algorithms. This paper is a comparative study of robustness of SOC estimation algorithms against modeling errors and measurement noises. By using a typical battery platform for vehicle applications with sensor noise and battery aging characterization, three popular and representative SOC estimation methods (extended Kalman filter, PI-controlled observer, and H∞ observer are compared on such robustness. The simulation and experimental results demonstrate that deterioration of SOC estimation accuracy under modeling errors resulted from aging and larger measurement noise, which is quantitatively characterized. The findings of this paper provide useful information on the following aspects: (1 how SOC estimation accuracy depends on modeling reliability and voltage measurement accuracy; (2 pros and cons of typical SOC estimators in their robustness and reliability; (3 guidelines for requirements on battery system identification and sensor selections.

  15. Suppressor of cytokine signaling 4 (SOCS4 protects against severe cytokine storm and enhances viral clearance during influenza infection.

    Directory of Open Access Journals (Sweden)

    Lukasz Kedzierski

    2014-05-01

    Full Text Available Suppressor of cytokine signaling (SOCS proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pathogenic H1N1 influenza virus (PR8 and are hypersusceptible to infection with the less virulent H3N2 (X31 strain. In SOCS4-deficient animals, this led to substantially greater weight loss, dysregulated pro-inflammatory cytokine and chemokine production in the lungs and delayed viral clearance. This was associated with impaired trafficking of influenza-specific CD8 T cells to the site of infection and linked to defects in T cell receptor activation. These results demonstrate that SOCS4 is a critical regulator of anti-viral immunity.

  16. Mapping SOC (Soil Organic Carbon) using LiDAR-derived vegetation indices in a random forest regression model

    Science.gov (United States)

    Will, R. M.; Glenn, N. F.; Benner, S. G.; Pierce, J. L.; Spaete, L.; Li, A.

    2015-12-01

    Quantifying SOC (Soil Organic Carbon) storage in complex terrain is challenging due to high spatial variability. Generally, the challenge is met by transforming point data to the entire landscape using surrogate, spatially-distributed, variables like elevation or precipitation. In many ecosystems, remotely sensed information on above-ground vegetation (e.g. NDVI) is a good predictor of below-ground carbon stocks. In this project, we are attempting to improve this predictive method by incorporating LiDAR-derived vegetation indices. LiDAR provides a mechanism for improved characterization of aboveground vegetation by providing structural parameters such as vegetation height and biomass. In this study, a random forest model is used to predict SOC using a suite of LiDAR-derived vegetation indices as predictor variables. The Reynolds Creek Experimental Watershed (RCEW) is an ideal location for a study of this type since it encompasses a strong elevation/precipitation gradient that supports lower biomass sagebrush ecosystems at low elevations and forests with more biomass at higher elevations. Sagebrush ecosystems composed of Wyoming, Low and Mountain Sagebrush have SOC values ranging from .4 to 1% (top 30 cm), while higher biomass ecosystems composed of aspen, juniper and fir have SOC values approaching 4% (top 30 cm). Large differences in SOC have been observed between canopy and interspace locations and high resolution vegetation information is likely to explain plot scale variability in SOC. Mapping of the SOC reservoir will help identify underlying controls on SOC distribution and provide insight into which processes are most important in determining SOC in semi-arid mountainous regions. In addition, airborne LiDAR has the potential to characterize vegetation communities at a high resolution and could be a tool for improving estimates of SOC at larger scales.

  17. Verklarende Afrikaanse woordeboek 8 as spieël van normverplasing

    African Journals Online (AJOL)

    They are also lauded for relaxing prescriptiveness regarding English loan words and Afrikaans colloquialisms. VAW8 is however criticised for its disregard of important metalexicographical developments of the past decade. It is argued that the implementation of theoretical insights could have contributed towards improved ...

  18. An Online SOC and SOH Estimation Model for Lithium-Ion Batteries

    Directory of Open Access Journals (Sweden)

    Shyh-Chin Huang

    2017-04-01

    Full Text Available The monitoring and prognosis of cell degradation in lithium-ion (Li-ion batteries are essential for assuring the reliability and safety of electric and hybrid vehicles. This paper aims to develop a reliable and accurate model for online, simultaneous state-of-charge (SOC and state-of-health (SOH estimations of Li-ion batteries. Through the analysis of battery cycle-life test data, the instantaneous discharging voltage (V and its unit time voltage drop, V′, are proposed as the model parameters for the SOC equation. The SOH equation is found to have a linear relationship with 1/V′ times the modification factor, which is a function of SOC. Four batteries are tested in the laboratory, and the data are regressed for the model coefficients. The results show that the model built upon the data from one single cell is able to estimate the SOC and SOH of the three other cells within a 5% error bound. The derived model is also proven to be robust. A random sampling test to simulate the online real-time SOC and SOH estimation proves that this model is accurate and can be potentially used in an electric vehicle battery management system (BMS.

  19. Effects of SOC-dependent electrolyte viscosity on performance of vanadium redox flow batteries

    International Nuclear Information System (INIS)

    Xu, Q.; Zhao, T.S.; Zhang, C.

    2014-01-01

    Highlights: • The correlations of electrolyte viscosity and SOC are obtained. • Effect of SOC-dependent electrolyte viscosity is considered in this model. • This model enables a more realistic simulation of variable distributions. • It provides accurate estimations of pumping work and system efficiency. - Abstract: The viscosity of the electrolyte in vanadium redox flow batteries (VRFBs) varies during charge and discharge as the concentrations of acid and vanadium ions in the electrolyte continuously change with the state of charge (SOC). In previous VRFB models, however, the electrolyte has been treated as a constant-viscosity solution. In this work, a mass-transport and electrochemical model taking account of the effect of SOC-dependent electrolyte viscosity is developed. The comparison between the present model and the model with the constant-viscosity simplification indicates that the consideration of the SOC-dependent electrolyte viscosity enables (i) a more realistic simulation of the distributions of overpotential and current density in the electrodes, and (ii) more accurate estimations of pumping work and the system efficiency of VRFBs

  20. SPIE 9639-49 Creation and Validation of Sintered PTFE BRDF Targets & Standards

    OpenAIRE

    Durell, Christopher; Scharpf, Dan; McKee, Greg; L’Heureux, Michelle; Georgiev, Georgi; Obein, Gael; Cooksey, Catherine

    2015-01-01

    Sintered polytetrafluoroethylene (PTFE) is an extremely stable, near-perfect Lambertian reflecting diffuser and calibration standard material that has been used by national labs, space, aerospace and commercial sectors for over two decades. New uncertainty targets of 2 % on-orbit absolute validation in the Earth Observing Systems community have challenged the industry to improve is characterization and knowledge of almost every aspect of radiometric performance (space and ground). Assuming “n...

  1. NEW EPICS/RTEMS IOC BASED ON ALTERA SOC AT JEFFERSON LAB

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Jianxun [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Seaton, Chad [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Allison, Trent L. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Bevins, Brian S. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Cuffe, Anthony W. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2018-02-01

    A new EPICS/RTEMS IOC based on the Altera System-on-Chip (SoC) FPGA is being designed at Jefferson Lab. The Altera SoC FPGA integrates a dual ARM Cortex-A9 Hard Processor System (HPS) consisting of processor, peripherals and memory interfaces tied seamlessly with the FPGA fabric using a high-bandwidth interconnect backbone. The embedded Altera SoC IOC has features of remote network boot via U-Boot from SD card or QSPI Flash, 1Gig Ethernet, 1GB DDR3 SDRAM on HPS, UART serial ports, and ISA bus interface. RTEMS for the ARM processor BSP were built with CEXP shell, which will dynamically load the EPICS applications at runtime. U-Boot is the primary bootloader to remotely load the kernel image into local memory from a DHCP/TFTP server over Ethernet, and automatically run RTEMS and EPICS. The first design of the SoC IOC will be compatible with Jefferson Lab’s current PC104 IOCs, which have been running in CEBAF 10 years. The next design would be mounting in a chassis and connected to a daughter card via standard HSMC connectors. This standard SoC IOC will become the next generation of low-level IOC for the accelerator controls at Jefferson Lab.

  2. Spieëlbeelde in die werk van Ingrid Jonker en Sylvia Plath

    Directory of Open Access Journals (Sweden)

    I. Gertenbach

    2008-07-01

    Full Text Available Mirror images in the work of Ingrid Jonker and Sylvia Plath Writing poetry has an element of healing in it, but how does it work? Plath and Jonker continually wrote about mirror images, eyes and questions of identity. Different psychological theories surrounding this issue, including those of Winnicott, Jung and Lacan, are discussed. Plath’s “Mirror” and “Words” as well as Jonker’s “Op alle gesigte” are specifically examined. Concluding remarks reveal that a mental block, or crypt, will always force a poet to reword his/her trauma.

  3. Gas-particle partitioning of semivolatile organic compounds (SOCs) on mixtures of aerosols in a smog chamber.

    Science.gov (United States)

    Chandramouli, Bharadwaj; Jang, Myoseon; Kamens, Richard M

    2003-09-15

    The partitioning behavior of a set of diverse SOCs on two and three component mixtures of aerosols from different sources was studied using smog chamber experimental data. A set of SOCs of different compound types was introduced into a system containing a mixture of aerosols from two or more sources. Gas and particle samples were taken using a filter-filter-denuder sampling system, and a partitioning coefficient Kp was estimated using Kp = Cp/(CgTSP). Particle size distributions were measured using a differential mobility analyzer and a light scattering detector. Gas and particle samples were analyzed using GCMS. The aerosol composition in the chamber was tracked chemically using a combination of signature compounds and the organic matter mass fraction (f(om)) of the individual aerosol sources. The physical nature of the aerosol mixture in the chamber was determined using particle size distributions, and an aggregate Kp was estimated from theoretically calculated Kp on the individual sources. Model fits for Kp showed that when the mixture involved primary sources of aerosol, the aggregate Kp of the mixture could be successfully modeled as an external mixture of the Kp on the individual aerosols. There were significant differences observed for some SOCs between modeling the system as an external and as an internal mixture. However, when one of the aerosol sources was secondary, the aggregate model Kp required incorporation of the secondary aerosol products on the preexisting aerosol for adequate model fits. Modeling such a system as an external mixture grossly overpredicted the Kp of alkanes in the mixture. Indirect evidence of heterogeneous, acid-catalyzed reactions in the particle phase was also seen, leading to a significant increase in the polarity of the resulting aerosol mix and a resulting decrease in the observed Kp of alkanes in the chamber. The model was partly consistent with this decrease but could not completely explain the reduction in Kp because of

  4. Clock generators for SOC processors circuits and architectures

    CERN Document Server

    Fahim, Amr

    2004-01-01

    This book explores the design of fully-integrated frequency synthesizers suitable for system-on-a-chip (SOC) processors. The text takes a more global design perspective in jointly examining the design space at the circuit level as well as at the architectural level. The comprehensive coverage includes summary chapters on circuit theory as well as feedback control theory relevant to the operation of phase locked loops (PLLs). On the circuit level, the discussion includes low-voltage analog design in deep submicron digital CMOS processes, effects of supply noise, substrate noise, as well device noise. On the architectural level, the discussion includes PLL analysis using continuous-time as well as discrete-time models, linear and nonlinear effects of PLL performance, and detailed analysis of locking behavior. The book provides numerous real world applications, as well as practical rules-of-thumb for modern designers to use at the system, architectural, as well as the circuit level.

  5. Study on SOC wavelet analysis for LiFePO4 battery

    Science.gov (United States)

    Liu, Xuepeng; Zhao, Dongmei

    2017-08-01

    Improving the prediction accuracy of SOC can reduce the complexity of the conservative and control strategy of the strategy such as the scheduling, optimization and planning of LiFePO4 battery system. Based on the analysis of the relationship between the SOC historical data and the external stress factors, the SOC Estimation-Correction Prediction Model based on wavelet analysis is established. Using wavelet neural network prediction model is of high precision to achieve forecast link, external stress measured data is used to update parameters estimation in the model, implement correction link, makes the forecast model can adapt to the LiFePO4 battery under rated condition of charge and discharge the operating point of the variable operation area. The test results show that the method can obtain higher precision prediction model when the input and output of LiFePO4 battery are changed frequently.

  6. Effects of different soil types in natural Mediterranean areas on soil organic carbon (SOC)

    Science.gov (United States)

    Requejo Silva, Ana; Lozano García, Beatriz; Parras Alcántara, Luis

    2017-04-01

    Effects of different soil types in natural Mediterranean areas on soil organic carbon (SOC) Ana Requejo1, Beatriz Lozano-García1, Luis Parras Alcántara1 1 Department of Agricultural Chemistry and Soil Science, Faculty of Science, Agrifood Campus of International Excellence - ceiA3, University of Córdoba, Spain. The carbon content of the atmosphere can be influenced by soils, since they can store carbon or emit large quantities of CO2. C sequestration into soils is one of the most important ecosystems services because of its role in climate regulation (IPPC, 2007). Thereof, agriculture and forestry are the only activities that can contribute to C sequestration through photosynthesis and its carbon incorporation into carbohydrates (Parras Alcántara et al., 2013). Dehesa is a multifunctional agro-sylvo-pastoral system and typical landscape of southern and central Spain and southern Portugal. It is an anthropogenic system dedicated to the combined production of black iberian pigs, a variety of foods, fuel, coal, and cork. Besides, it acts as well in the production of endangered species as wildlife habitat and as sustainable hunting areas. These dehesa areas are defined by a relationship between productivity and conservation of forest oaks, providing environmental benefits such as carbon capture and storage. The area focused in this study is the Cardeña-Montoro Nature Reserve, located within the Sierra Morena (Córdoba, South Spain). The most representative soils in Cardeña-Montoro Nature Reserve are Cambisols, Regosols, Leptosols and Fluvisols according to IUSS Working Group WRB (2006). They are characterized by a low fertility, poor physical conditions and marginal capacity for agricultural use, along with low organic matter content due to climate conditions (semiarid Mediterranean climate) and soil texture (sandy). Several studies have shown that land use affects the SOC concentration (Lozano-García et al., 2016; Khaledian et al., 2016). Based on this

  7. Effects of Extracurricular Participation on the Internalizing Problems and Intrapersonal Strengths of Youth in a System of Care.

    Science.gov (United States)

    Abraczinskas, Michelle; Kilmer, Ryan; Haber, Mason; Cook, James; Zarrett, Nicole

    2016-06-01

    Although extracurricular participation has been linked to positive youth outcomes in the general population, no research to date has examined benefits for youth diagnosed with mental health challenges. Youth in systems of care (SOCs) receive a variety of services and supports that could help them capitalize on this potential for positive development, such as access to flexible funding to support recreational interests. However, research has not examined the degree to which the increased community involvement (e.g., extracurricular participation) sought in SOCs contributes to improved outcomes. This study addresses these gaps by investigating the relationships between both average and increased extracurricular participation frequency and breadth and internalizing problems and intrapersonal strengths among SOC youth. Findings revealed that, on average, higher frequency of youth participation was associated with higher intrapersonal strengths and lower internalizing problems. Increases in participation frequency were also associated with increased strengths and decreased internalizing problems. These findings suggest that efforts to implement supports for increasing extracurricular participation of SOC youth could improve their psychosocial outcomes beyond the benefits yielded via formal services. Taken together, these results provide support for advocacy efforts to integrate youth with mental health challenges into existing extracurriculars and to create new extracurricular opportunities. © Society for Community Research and Action 2016.

  8. The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells

    DEFF Research Database (Denmark)

    Emanuelli, Brice; Glondu, Murielle; Filloux, Chantal

    2004-01-01

    insulin signaling is required for the optimal beta-cell function, we assessed the effect of IL-1beta on the insulin pathway in a rat pancreatic beta-cell line. We show that IL-1beta decreases insulin-induced tyrosine phosphorylation of the insulin receptor (IR) and insulin receptor substrate (IRS...

  9. EpSoc: Social-Based Epidemic-Based Routing Protocol in Opportunistic Mobile Social Network

    Directory of Open Access Journals (Sweden)

    Halikul Lenando

    2018-01-01

    Full Text Available In opportunistic networks, the nature of intermittent and disruptive connections degrades the efficiency of routing. Epidemic routing protocol is used as a benchmark for most of routing protocols in opportunistic mobile social networks (OMSNs due to its high message delivery and latency. However, Epidemic incurs high cost in terms of overhead and hop count. In this paper, we propose a hybrid routing protocol called EpSoc which utilizes the Epidemic routing forwarding strategy and exploits an important social feature, that is, degree centrality. Two techniques are used in EpSoc. Messages’ TTL is adjusted based on the degree centrality of nodes, and the message blocking mechanism is used to control replication. Simulation results show that EpSoc increases the delivery ratio and decreases the overhead ratio, the average latency, and the hop counts as compared to Epidemic and Bubble Rap.

  10. SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth hormone in rat adipocytes by inhibition of Jak2/IRS-1 signaling

    DEFF Research Database (Denmark)

    Ridderstråle, M; Amstrup, J; Hilton, D J

    2003-01-01

    One of the long-term effects of growth hormone (GH) in adipocytes is to maintain a state of refractoriness to insulin-like effects, a refractoriness which otherwise declines within a few hours of GH starvation. Here, we examined differences in GH signaling and the possible role for the recently i...

  11. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules.

    Directory of Open Access Journals (Sweden)

    Takanobu Nagata

    Full Text Available Myocardial ischemia reperfusion injury (IRI adversely affects cardiac performance and the prognosis of patients with acute myocardial infarction. Although myocardial signal transducer and activator of transcription (STAT 3 is potently cardioprotective during IRI, the inhibitory mechanism responsible for its activation is largely unknown. The present study aimed to investigate the role of the myocardial suppressor of cytokine signaling (SOCS-3, an intrinsic negative feedback regulator of the Janus kinase (JAK-STAT signaling pathway, in the development of myocardial IRI. Myocardial IRI was induced in mice by ligating the left anterior descending coronary artery for 1 h, followed by different reperfusion times. One hour after reperfusion, the rapid expression of JAK-STAT-activating cytokines was observed. We precisely evaluated the phosphorylation of cardioprotective signaling molecules and the expression of SOCS3 during IRI and then induced myocardial IRI in wild-type and cardiac-specific SOCS3 knockout mice (SOCS3-CKO. The activation of STAT3, AKT, and ERK1/2 rapidly peaked and promptly decreased during IRI. This decrease correlated with the induction of SOCS3 expression up to 24 h after IRI in wild-type mice. The infarct size 24 h after reperfusion was significantly reduced in SOCS3-CKO compared with wild-type mice. In SOCS3-CKO mice, STAT3, AKT, and ERK1/2 phosphorylation was sustained, myocardial apoptosis was prevented, and the expression of anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1 was augmented. Cardiac-specific SOCS3 deletion led to the sustained activation of cardioprotective signaling molecules including and prevented myocardial apoptosis and injury during IRI. Our findings suggest that SOCS3 may represent a key factor that exacerbates the development of myocardial IRI.

  12. SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients.

    Science.gov (United States)

    Feng, Ying; Wang, Zheng; Bao, Zhaoshi; Yan, Wei; You, Gan; Wang, Yinyan; Hu, Huimin; Zhang, Wei; Zhang, Quangeng; Jiang, Tao

    2014-01-01

    Hypermethylation of the suppressor of cytokine signaling 3(SOCS3) promoter has been reported to predict a poor prognosis in several cancers including glioblastoma multiforme (GBM). We explored the function of SOCS3 promoter hypermethylation in GBM cohorts, including analysis of the CpG island methylator phenotype (CIMP), when a large number of gene loci are simultaneously hypermethylated. A whole genome promoter methylation profile was performed in a cohort of 33 GBM samples, with 13 long-term survivors (LTS; overall survival ≥ 18 months) and 20 short-term survivors (STS; overall survival ≤ 9 months). The SOCS3 promoter methylation status was compared between the two groups. In addition, we investigated the relationship of SOCS3 promoter methylation and G-CIMP status. Interestingly, in our present study, we found that SOCS3 promoter methylation was statistically significantly higher in the 13 LTS than that in the 20 STS. Furthermore, high SOCS3 promoter methylation detected via pyro-sequencing predicted a better prognosis in an independent cohort containing 62 GBM patients. This correlation was validated by the dataset from the Cancer Genome Atlas(TCGA) and the Chinese Cancer Genome Atlas(CGGA). In addition, we found that hypermethylation of the SOCS3 promoter was tightly associated with the G-CIMP-positive GBM patients. Using a total of 359 clinical samples, we demonstrate that SOCS3 promoter hypermethylation status has a favorable prognostic value in GBM patients because of whole genome methylation status. Particularly, the hypermethylation of the SOCS3 promoter indicates positive G-CIMP status.

  13. SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients.

    Directory of Open Access Journals (Sweden)

    Ying Feng

    Full Text Available Hypermethylation of the suppressor of cytokine signaling 3(SOCS3 promoter has been reported to predict a poor prognosis in several cancers including glioblastoma multiforme (GBM. We explored the function of SOCS3 promoter hypermethylation in GBM cohorts, including analysis of the CpG island methylator phenotype (CIMP, when a large number of gene loci are simultaneously hypermethylated.A whole genome promoter methylation profile was performed in a cohort of 33 GBM samples, with 13 long-term survivors (LTS; overall survival ≥ 18 months and 20 short-term survivors (STS; overall survival ≤ 9 months. The SOCS3 promoter methylation status was compared between the two groups. In addition, we investigated the relationship of SOCS3 promoter methylation and G-CIMP status.Interestingly, in our present study, we found that SOCS3 promoter methylation was statistically significantly higher in the 13 LTS than that in the 20 STS. Furthermore, high SOCS3 promoter methylation detected via pyro-sequencing predicted a better prognosis in an independent cohort containing 62 GBM patients. This correlation was validated by the dataset from the Cancer Genome Atlas(TCGA and the Chinese Cancer Genome Atlas(CGGA. In addition, we found that hypermethylation of the SOCS3 promoter was tightly associated with the G-CIMP-positive GBM patients.Using a total of 359 clinical samples, we demonstrate that SOCS3 promoter hypermethylation status has a favorable prognostic value in GBM patients because of whole genome methylation status. Particularly, the hypermethylation of the SOCS3 promoter indicates positive G-CIMP status.

  14. Fundamentals of IP and SoC security design, verification, and debug

    CERN Document Server

    Ray, Sandip; Sur-Kolay, Susmita

    2017-01-01

    This book is about security in embedded systems and it provides an authoritative reference to all aspects of security in system-on-chip (SoC) designs. The authors discuss issues ranging from security requirements in SoC designs, definition of architectures and design choices to enforce and validate security policies, and trade-offs and conflicts involving security, functionality, and debug requirements. Coverage also includes case studies from the “trenches” of current industrial practice in design, implementation, and validation of security-critical embedded systems. Provides an authoritative reference and summary of the current state-of-the-art in security for embedded systems, hardware IPs and SoC designs; Takes a "cross-cutting" view of security that interacts with different design and validation components such as architecture, implementation, verification, and debug, each enforcing unique trade-offs; Includes high-level overview, detailed analysis on implementation, and relevant case studies on desi...

  15. Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3 Function and Expression

    Directory of Open Access Journals (Sweden)

    Jamie J. L. Williams

    2014-05-01

    Full Text Available The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small molecule inhibitors and biologicals. In this review, we discuss JAK-STAT signalling pathway inhibition by the inducible inhibitor “suppressor of cytokine signaling 3 (SOCS3, its role in diseases such as myeloproliferative disorders, and its function as part of a multi-subunit E3 ubiquitin ligase complex. In addition, we highlight potential applications of these insights into SOCS3-based therapeutic strategies for management of conditions such as vascular re-stenosis associated with acute vascular injury, where there is strong evidence that multiple processes involved in disease progression could be attenuated by localized potentiation of SOCS3 expression levels.

  16. Matching soil grid unit resolutions with polygon unit scales for DNDC modelling of regional SOC pool

    Science.gov (United States)

    Zhang, H. D.; Yu, D. S.; Ni, Y. L.; Zhang, L. M.; Shi, X. Z.

    2015-03-01

    Matching soil grid unit resolution with polygon unit map scale is important to minimize uncertainty of regional soil organic carbon (SOC) pool simulation as their strong influences on the uncertainty. A series of soil grid units at varying cell sizes were derived from soil polygon units at the six map scales of 1:50 000 (C5), 1:200 000 (D2), 1:500 000 (P5), 1:1 000 000 (N1), 1:4 000 000 (N4) and 1:14 000 000 (N14), respectively, in the Tai lake region of China. Both format soil units were used for regional SOC pool simulation with DeNitrification-DeComposition (DNDC) process-based model, which runs span the time period 1982 to 2000 at the six map scales, respectively. Four indices, soil type number (STN) and area (AREA), average SOC density (ASOCD) and total SOC stocks (SOCS) of surface paddy soils simulated with the DNDC, were attributed from all these soil polygon and grid units, respectively. Subjecting to the four index values (IV) from the parent polygon units, the variation of an index value (VIV, %) from the grid units was used to assess its dataset accuracy and redundancy, which reflects uncertainty in the simulation of SOC. Optimal soil grid unit resolutions were generated and suggested for the DNDC simulation of regional SOC pool, matching with soil polygon units map scales, respectively. With the optimal raster resolution the soil grid units dataset can hold the same accuracy as its parent polygon units dataset without any redundancy, when VIV indices was assumed as criteria to the assessment. An quadratic curve regression model y = -8.0 × 10-6x2 + 0.228x + 0.211 (R2 = 0.9994, p < 0.05) was revealed, which describes the relationship between optimal soil grid unit resolution (y, km) and soil polygon unit map scale (1:x). The knowledge may serve for grid partitioning of regions focused on the investigation and simulation of SOC pool dynamics at certain map scale.

  17. Factors whıch Efects the Mobıle Taggıng Awareness; A Research on Socıal Medıa Consumers

    OpenAIRE

    Kübra Küge DALDAL; Sabiha KILIÇ

    2014-01-01

    This study intends to determine the factors which effects the awareness of social media consumers. The basic assumption of the study is social media consumers awareness about mobile marketing is at high level. Social media consumers follow technology, technological innovation and mobile applications. In the study mobile tags are considered as a brand. Brand awareness is related to the strength of the brand assets in the mind of the consumers.  Brand awareness is measured in six wa...

  18. Advanced Technology for Ultra-Low Power System-on-Chip (SoC)

    Science.gov (United States)

    2017-06-01

    was proposed for lower power applications with Ioff=10pA/μm and VDD=0.5V. In this project, the optimized structure shows great potential in both Lg...AFRL-RY-WP-TR-2017-0115 ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON-CHIP (SoC) Jason Woo, Weicong Li, and Peng Lu University of California...September 2015 – 31 March 2017 4. TITLE AND SUBTITLE ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON- CHIP (SoC) 5a. CONTRACT NUMBER FA8650-15-1-7574 5b

  19. SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.

    Science.gov (United States)

    Sugden, Peter H; McGuffin, Liam J; Clerk, Angela

    2013-08-15

    The GCKIII (germinal centre kinase III) subfamily of the mammalian Ste20 (sterile 20)-like group of serine/threonine protein kinases comprises SOK1 (Ste20-like/oxidant-stress-response kinase 1), MST3 (mammalian Ste20-like kinase 3) and MST4. Initially, GCKIIIs were considered in the contexts of the regulation of mitogen-activated protein kinase cascades and apoptosis. More recently, their participation in multiprotein heterocomplexes has become apparent. In the present review, we discuss the structure and phosphorylation of GCKIIIs and then focus on their interactions with other proteins. GCKIIIs possess a highly-conserved, structured catalytic domain at the N-terminus and a less-well conserved C-terminal regulatory domain. GCKIIIs are activated by tonic autophosphorylation of a T-loop threonine residue and their phosphorylation is regulated primarily through protein serine/threonine phosphatases [especially PP2A (protein phosphatase 2A)]. The GCKIII regulatory domains are highly disorganized, but can interact with more structured proteins, particularly the CCM3 (cerebral cavernous malformation 3)/PDCD10 (programmed cell death 10) protein. We explore the role(s) of GCKIIIs (and CCM3/PDCD10) in STRIPAK (striatin-interacting phosphatase and kinase) complexes and their association with the cis-Golgi protein GOLGA2 (golgin A2; GM130). Recently, an interaction of GCKIIIs with MO25 has been identified. This exhibits similarities to the STRADα (STE20-related kinase adaptor α)-MO25 interaction (as in the LKB1-STRADα-MO25 heterotrimer) and, at least for MST3, the interaction may be enhanced by cis-autophosphorylation of its regulatory domain. In these various heterocomplexes, GCKIIIs associate with the Golgi apparatus, the centrosome and the nucleus, as well as with focal adhesions and cell junctions, and are probably involved in cell migration, polarity and proliferation. Finally, we consider the association of GCKIIIs with a number of human diseases, particularly

  20. Implementation of a Loosely-Coupled Lockstep Approach in the Xilinx Zynq-7000 All Programmable SoC for High Consequence Applications

    Science.gov (United States)

    2017-03-01

    Programmable SoC™ is made possible through the use of ARM® Cortex ™-A9 MPCore™ Asymmetric Multiprocessing; processor configurations utilizing the...core ARM Cortex -A9 MPCore based Processing System (PS) and Programmable Logic (PL) portions. These features allow for two processors to run...SoC™ precludes a tightly-coupled lockstep approach between the two processors . Therefore, a loosely-coupled lockstep approach implemented by a

  1. Longevity of contributions to SOC stocks from roots and aboveground plant litter below a Miscanthus plantation

    Science.gov (United States)

    Robertson, Andrew; Smith, Pete; Davies, Christian; Bottoms, Emily; McNamara, Niall

    2013-04-01

    Miscanthus is a lignocellulosic crop that uses the Hatch-Slack (C4) photosynthetic pathway as opposed to most C3 vegetation native to the UK. Miscanthus can be grown for a number of practical end-uses but recently interest has increased in its viability as a bioenergy crop; both providing a renewable source of energy and helping to limit climate change by improving the carbon (C) budgets associated with energy generation. Recent studies have shown that Miscanthus plantations may increase stocks of soil organic carbon (SOC), however the longevity and origin of this 'new' SOC must be assessed. Consequently, we combined an input manipulation experiment with physio-chemical soil fractionation to quantify new SOC and CO2 emissions from Miscanthus roots, decomposing plant litter and soil individually. Further, fractionation of SOC from the top 30 cm gave insight into the longevity of that SOC. In January 2009 twenty-five 2 m2 plots were set up in a three-year old 11 hectare Miscanthus plantation in Lincolnshire, UK; with five replicates of five treatments. These treatments varied plant input to the soil by way of controlled exclusion techniques. Treatments excluded roots only ("No Roots"), surface litter only ("No Litter"), both roots and surface litter ("No Roots or Litter") or had double the litter amount added to the soil surface ("Double Litter"). A fifth treatment was a control with undisturbed roots and an average amount of litter added. Monthly measurements of CO2 emissions were taken at the soil surface from each treatment between March 2009 and March 2013, and soil C from the top 30 cm was monitored in all plots over the same period. Miscanthus-derived SOC was determined using the isotopic discrimination between C4 plant matter and C3 soil, and soil fractionation was then used to establish the longevity of that Miscanthus-derived SOC. Ongoing results for CO2 emissions indicate a strong seasonal variation; litter decomposition forms a large portion of the CO2

  2. Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: role of the S100A4-miR155-SOCS1-MMP9 axis.

    Science.gov (United States)

    Yan, Xin-Long; Jia, Ya-Li; Chen, Lin; Zeng, Quan; Zhou, Jun-Nian; Fu, Chun-Jiang; Chen, Hai-Xu; Yuan, Hong-Feng; Li, Zhi-Wei; Shi, Lei; Xu, Ying-Chen; Wang, Jing-Xue; Zhang, Xiao-Mei; He, Li-Juan; Zhai, Chao; Yue, Wen; Pei, Xue-Tao

    2013-06-01

    Cancer-associated mesenchymal stem cells (MSCs) play a pivotal role in modulating tumor progression. However, the interactions between liver cancer-associated MSCs (LC-MSCs) and hepatocellular carcinoma (HCC) remain unreported. Here, we identified the presence of MSCs in HCC tissues. We also showed that LC-MSCs significantly enhanced tumor growth in vivo and promoted tumor sphere formation in vitro. LC-MSCs also promoted HCC metastasis in an orthotopic liver transplantation model. Complementary DNA (cDNA) microarray analysis showed that S100A4 expression was significantly higher in LC-MSCs compared with liver normal MSCs (LN-MSCs) from adjacent cancer-free tissues. Importantly, the inhibition of S100A4 led to a reduction of proliferation and invasion of HCC cells, while exogenous S100A4 expression in HCC cells resulted in heavier tumors and more metastasis sites. Our results indicate that S100A4 secreted from LC-MSCs can promote HCC cell proliferation and invasion. We then found the expression of oncogenic microRNA (miR)-155 in HCC cells was significantly up-regulated by coculture with LC-MSCs and by S100A4 ectopic overexpression. The invasion-promoting effects of S100A4 were significantly attenuated by a miR-155 inhibitor. These results suggest that S100A4 exerts its effects through the regulation of miR-155 expression in HCC cells. We demonstrate that S100A4 secreted from LC-MSCs promotes the expression of miR-155, which mediates the down-regulation of suppressor of cytokine signaling 1, leading to the subsequent activation of STAT3 signaling. This promotes the expression of matrix metalloproteinases 9, which results in increased tumor invasiveness. S100A4 secreted from LC-MSCs is involved in the modulation of HCC progression, and may be a potential therapeutic target. (HEPATOLOGY 2013). Copyright © 2013 American Association for the Study of Liver Diseases.

  3. The international development challenge

    International Nuclear Information System (INIS)

    Anon.

    1998-01-01

    Markets are opening up to international competition and new opportunities will arise for companies. The first part of this international round table of the French gas association's annual conference was devoted to whether they have all necessary assets, especially in terms of know-how and new technologies. In the second part of this round table, gas industry leaders presented their ambitions and strategies on the international scene. The questions discussed related to the main areas of development from both business and geographic viewpoints; to the underlying factors such as expertise, technological know-how, market risks and potential, strategic alliances. (authors)

  4. ORCHIDEE-SOM: modeling soil organic carbon (SOC) and dissolved organic carbon (DOC) dynamics along vertical soil profiles in Europe

    Science.gov (United States)

    Camino-Serrano, Marta; Guenet, Bertrand; Luyssaert, Sebastiaan; Ciais, Philippe; Bastrikov, Vladislav; De Vos, Bruno; Gielen, Bert; Gleixner, Gerd; Jornet-Puig, Albert; Kaiser, Klaus; Kothawala, Dolly; Lauerwald, Ronny; Peñuelas, Josep; Schrumpf, Marion; Vicca, Sara; Vuichard, Nicolas; Walmsley, David; Janssens, Ivan A.

    2018-03-01

    Current land surface models (LSMs) typically represent soils in a very simplistic way, assuming soil organic carbon (SOC) as a bulk, and thus impeding a correct representation of deep soil carbon dynamics. Moreover, LSMs generally neglect the production and export of dissolved organic carbon (DOC) from soils to rivers, leading to overestimations of the potential carbon sequestration on land. This common oversimplified processing of SOC in LSMs is partly responsible for the large uncertainty in the predictions of the soil carbon response to climate change. In this study, we present a new soil carbon module called ORCHIDEE-SOM, embedded within the land surface model ORCHIDEE, which is able to reproduce the DOC and SOC dynamics in a vertically discretized soil to 2 m. The model includes processes of biological production and consumption of SOC and DOC, DOC adsorption on and desorption from soil minerals, diffusion of SOC and DOC, and DOC transport with water through and out of the soils to rivers. We evaluated ORCHIDEE-SOM against observations of DOC concentrations and SOC stocks from four European sites with different vegetation covers: a coniferous forest, a deciduous forest, a grassland, and a cropland. The model was able to reproduce the SOC stocks along their vertical profiles at the four sites and the DOC concentrations within the range of measurements, with the exception of the DOC concentrations in the upper soil horizon at the coniferous forest. However, the model was not able to fully capture the temporal dynamics of DOC concentrations. Further model improvements should focus on a plant- and depth-dependent parameterization of the new input model parameters, such as the turnover times of DOC and the microbial carbon use efficiency. We suggest that this new soil module, when parameterized for global simulations, will improve the representation of the global carbon cycle in LSMs, thus helping to constrain the predictions of the future SOC response to global

  5. Spatial variability of soil carbon across Mexico and the United States

    Science.gov (United States)

    Vargas, R.; Guevara, M.; Cruz Gaistardo, C.; Paz, F.; de Jong, B.; Etchevers, J.

    2015-12-01

    Soil organic carbon (SOC) is directly linked to soil quality, food security, and land use/global environmental change. We use publicly available information on SOC and couple it with digital elevation models and derived terrain attributes using a machine learning approach. We found a strong spatial dependency of SOC across the United States, but less spatial dependency of SOC across Mexico. Using High Performance Computing (HPC) we derived a 1 km resolution map of SOC across Mexico and the United States. We tested different machine learning methods (e.g., kernel based, tree based and/or Geo-statistics approaches) for computational efficiency and statistical accuracy. Using random forest combined with geo-statistics we were able to explain >70% of SOC variance for Mexico and >40% in the case of the United States via cross validation. These results compare with other published estimates of SOC at 1km resolution that only explain <30% of SOC variance across the world. Topographic attributes derived from digital elevation models are freely available globally at fine spatial resolution (<100 m), and this information allowed us to make predictions of SOC at fine scales. We further tested this approach using SOC information from the International Soil Carbon Network to predict SOC in other regions of the world. We conclude that this approach (using public information and open source platforms for data analysis) could be implemented to predict detailed explicit information of SOC across different spatial scales.

  6. SoC Estimation for Lithium-ion Batteries: Review and Future Challenges

    Directory of Open Access Journals (Sweden)

    Juan Pablo Rivera-Barrera

    2017-11-01

    Full Text Available Energy storage emerged as a top concern for the modern cities, and the choice of the lithium-ion chemistry battery technology as an effective solution for storage applications proved to be a highly efficient option. State of charge (SoC represents the available battery capacity and is one of the most important states that need to be monitored to optimize the performance and extend the lifetime of batteries. This review summarizes the methods for SoC estimation for lithium-ion batteries (LiBs. The SoC estimation methods are presented focusing on the description of the techniques and the elaboration of their weaknesses for the use in on-line battery management systems (BMS applications. SoC estimation is a challenging task hindered by considerable changes in battery characteristics over its lifetime due to aging and to the distinct nonlinear behavior. This has led scholars to propose different methods that clearly raised the challenge of establishing a relationship between the accuracy and robustness of the methods, and their low complexity to be implemented. This paper publishes an exhaustive review of the works presented during the last five years, where the tendency of the estimation techniques has been oriented toward a mixture of probabilistic techniques and some artificial intelligence.

  7. Computational model of 18650 lithium-ion battery with coupled strain rate and SOC dependencies

    International Nuclear Information System (INIS)

    Xu, Jun; Liu, Binghe; Wang, Xinyi; Hu, Dayong

    2016-01-01

    Highlights: • An anisotropic model to describe mechanical behaviors of LIB is established. • SOC dependency is included in the mechanical model of the jellyroll. • Dynamic effect is considered in the model for LIB. - Abstract: Highly nonlinear structures and constituent materials and hazardous experiment situations have resulted in a pressing need for a numerical mechanical model for lithium-ion battery (LIB). However, such a model is still not well established. In this paper, an anisotropic homogeneous model describing the jellyroll and the battery shell is established and validated through compression, indentation, and bending tests at quasi-static loadings. In this model, state-of-charge (SOC) dependency of the LIB is further included through an analogy with the strain-rate effect. Moreover, with consideration of the inertia and strain-rate effects, the anisotropic homogeneous model is extended into the dynamic regime and proven capable of predicting the dynamic response of the LIB using the drop-weight test. The established model may help to predict extreme cases with high SOCs and crashing speeds with an over 135% improved accuracy compared to traditional models. The established coupled strain rate and SOC dependencies of the numerical mechanical model for the LIB aims to provide a solid step toward unraveling and quantifying the complicated problems for research on LIB mechanical integrity.

  8. 3D integration for NoC-based SoC architectures

    CERN Document Server

    Sheibanyrad, Abbas; Pétrot, Frédéric

    2011-01-01

    3D-Integration for NoC-based SoC Architectures gathers the recent advances in the whole domain by renowned experts in the field to build a comprehensive and consistent book around the hot topics of three-dimensional architectures and micro-architectures.

  9. A Flexible ADC Approach for Mixed-signal SoC Platforms

    NARCIS (Netherlands)

    Zanikopoulos, A.; Harpe, P.J.A.; Hegt, J.A.; Roermund, van A.H.M.

    2005-01-01

    Time-to-market pressure and increased design complexity created what is called a "design gap" [1] in the design of systems-on-chip (SoC). As a solution to that problem the Platform-Based Design (PBD), based on the design-reuse methodology, has been proposed [2], and successfully applied to digital

  10. An overview of online implementable SOC estimation methods for Lithium-ion batteries

    DEFF Research Database (Denmark)

    Jinhao, Meng; Ricco, Mattia; Guangzhao, Luo

    2017-01-01

    With the popularity of Electrical Vehicles (EVs), Lithium-ion battery industry is also developing rapidly. To ensure the battery safety usage and reduce the average lifecycle cost, accurate State Of Charge (SOC) tracking algorithms for real-time implementation are required in different applications...

  11. Design of a Bidirectional Energy Storage System for a Vanadium Redox Flow Battery in a Microgrid with SOC Estimation

    Directory of Open Access Journals (Sweden)

    Qingwu Gong

    2017-03-01

    Full Text Available This paper used a Vanadium Redox flow Battery (VRB as the storage battery and designed a two-stage topology of a VRB energy storage system in which a phase-shifted full bridge dc-dc converter and three-phase inverter were used, considering the low terminal voltage of the VRB. Following this, a model of the VRB was simplified, according to the operational characteristics of the VRB in this designed topology of a VRB energy storage system (ESS. By using the simplified equivalent model of the VRB, the control parameters of the ESS were designed. For effectively estimating the state of charge (SOC of the VRB, a traditional method for providing the SOC estimation was simplified, and a simple and effective SOC estimation method was proposed in this paper. Finally, to illustrate the proper design of the VRB ESS and the proposed SOC estimation method, a corresponding simulation was designed by Simulink. The test results have demonstrated that this proposed SOC estimation method is feasible and effective for indicating the SOC of a VRB and the proper design of this VRB ESS is very reasonable for VRB applications.

  12. The international nuclear technology

    International Nuclear Information System (INIS)

    Remick, F.J.

    1992-01-01

    With today's technology, isolationism is virtually impossible. The world's economies are so strongly intertwined that what affects one country will, in some way, influence another. Nuclear technology is no exception. If anything, nuclear technology is a catalyst for international cooperation. In the United States of America, nuclear technology is undergoing significant changes. Many of these changes are being greatly influenced by programs of international cooperation

  13. Increasing SoC Dependability via Known Good Tile NoC Testing

    NARCIS (Netherlands)

    Kerkhoff, Hans G.; Kuiken, O.J.; Zhang, X.

    2008-01-01

    Advanced CMOS technology possibilities, power, communication and flexibility issues as well as the design gap are directing System-on-Chip (SoC) platforms towards Network-on-Chip (NoC) interconnected identical processing tiles (PT) such as the Montium processor [1]. It is broadly acknowledged that

  14. An Overview and Comparison of Online Implementable SOC Estimation Methods for Lithium-ion Battery

    DEFF Research Database (Denmark)

    Meng, Jinhao; Ricco, Mattia; Luo, Guangzhao

    2018-01-01

    With the popularity of Electrical Vehicles (EVs), Lithium-ion battery industry is developing rapidly. To ensure the battery safe usage and to reduce its average lifecycle cost, an accurate State of Charge (SOC) tracking algorithms for real-time implementation are required for different applications...

  15. Analysis of Suppressor of Cytokine Signaling 2 Gene (SOCS2 Polymorphism in Different Dog Breeds

    Directory of Open Access Journals (Sweden)

    Martina Miluchová

    2011-05-01

    Full Text Available SOCS2 is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. The aim of the paper was to identify of suppressor of cytokine signaling 2 gene (SOCS2 polymorphism in different dog breeds. The material involved 77 dogs from 14 different breeds. Canine genomic DNA was isolated from saliva by modified method with using DNAzol® (Molecular Research Center and linear polyacrylamide (LPA carrier and from blood by using NucleospinBlood (Macherey-Nagel and used in order to estimate SOCS2 genotypes by PCR-RFLP method. The PCR products were digested with TaqI restriction enzyme. The T allele was distributed among large dog breeds (Czech pointer, Golden retriever, Rottweiler with an allele frequency ranging from 0.2857 to 1.00. In the population of Czech pointer we detected all genotypes. There were detected homozygote genotype GG with frequency 0.5476, heterozygote genotype GT with frequency 0.3333 and homozygote genotype TT with frequency 0.1191. Results point out that frequency of G allele was high and was represented 0.7143. Frequency of T allele was 0.2857. In Rottweiler was detected homozygote genotype TT. Genotypes GG and GT has not been observed. In Golden retriever we detected only heterozygote genotype GT.

  16. Dynamics and fate of SOC in tidal marshes along a salinity gradient (Scheldt estuary, Belgium)

    Science.gov (United States)

    Van de Broek, Marijn; Temmermann, Stijn; Merckx, Roel; Wang, Zhengang; Govers, Gerard

    2016-04-01

    Coastal ecosystems have been attributed the potential to store large amounts of organic carbon (OC), often referred to as blue carbon, of which a considerable amount is stored in tidal marsh soils. Large uncertainties still exist with respect to the amount and controlling factors of soil organic carbon (SOC) stored in these ecosystems. Moreover, most research has focused on SOC dynamics of saltmarshes, while brackish and freshwater marshes are often even more productive and thus receive even larger organic carbon inputs. Therefore, in this study the OC dynamics of tidal marsh soils along an estuarine gradient are studied in order to contribute to our knowledge of 1) the stocks, 2) the controlling factors and 3) the fate of SOC in tidal marshes with different environmental characteristics. This research thus contributes to a better understanding of the potential of coastal environments to store organic carbon under future climatic changes. Soil and vegetation samples are collected in tidal salt-, brackish- and freshwater marshes in the Scheldt estuary (Belgium - The Netherlands). At each tidal marsh, three replicate soil cores up to 1.5m depth in 0.03m increments are collected at locations with both a low and a high elevation. These cores are analyzed for OC, stable C and N isotopes, bulk density and texture. Incubation experiments of topsoil samples were conducted and both aboveground and belowground biomass were collected. The results show that SOC stocks (range: 13,5 - 35,4 kg OC m-2), standing biomass (range: 2000 - 7930 g DW m-2) and potential soil respiration of CO2 (range: 0,03 - 0,12 % per unit OC per day) decrease with increasing salinity. This shows that both the amount of OC from local macrophytes and the quality of the organic matter are important factors controlling the SOC stocks. In addition, based on the analysis of stable C and N isotopes, it appears that when a significant fraction of SOC is derived from local macrophytes, higher SOC stocks are

  17. The International Space University

    Science.gov (United States)

    Davidian, Kenneth J.

    1990-01-01

    The International Space University (ISU) was founded on the premise that any major space program in the future would require international cooperation as a necessary first step toward its successful completion. ISU is devoted to being a leading center for educating future authorities in the world space industry. ISU's background, goals, current form, and future plans are described. The results and benefits of the type of education and experience gained from ISU include technical reports describing the design projects undertaken by the students, an exposure to the many different disciplines which are a part of a large space project, an awareness of the existing activities from around the world in the space community, and an international professional network which spans all aspects of space activities and covers the globe.

  18. The international safeguards profession

    International Nuclear Information System (INIS)

    Sanders, K.E.

    1986-01-01

    The International Atomic Energy Agency has established a staff of safeguards professionals who are responsible for carrying out on-site inspections to determine compliance with international safeguards agreements. By IAEA Statute, the paramount consideration in recruiting IAEA staff is to secure employees of the highest standards of efficiency, technical competence, and integrity. An analysis of the distribution of professionals in the IAEA Department of Safeguards has revealed some interesting observations regarding the distribution of grade levels, age, time in service, gender, and geographical origin. Following several earlier studies performed by contractors for ACDA, U.S. efforts have been undertaken to attract and better prepare candidates for working at the IAEA

  19. SoC Design Approach Using Convertibility Verification

    Directory of Open Access Journals (Sweden)

    Basu Samik

    2008-01-01

    Full Text Available Abstract Compositional design of systems on chip from preverified components helps to achieve shorter design cycles and time to market. However, the design process is affected by the issue of protocol mismatches, where two components fail to communicate with each other due to protocol differences. Convertibility verification, which involves the automatic generation of a converter to facilitate communication between two mismatched components, is a collection of techniques to address protocol mismatches. We present an approach to convertibility verification using module checking. We use Kripke structures to represent protocols and the temporal logic to describe desired system behavior. A tableau-based converter generation algorithm is presented which is shown to be sound and complete. We have developed a prototype implementation of the proposed algorithm and have used it to verify that it can handle many classical protocol mismatch problems along with SoC problems. The initial idea for -based convertibility verification was presented at SLA++P '07 as presented in the work by Roopak Sinha et al. 2008.

  20. The international RESPO network

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-01

    Winrock International, with sponsorship from the Center for Environment of the U.S. Agency for International Development (USAID) and the U.S. Export Council for Renewable Energy (US/ECRE), is building a global network of non-governmental organizations to help catalyze the use of renewable energy technologies for rural energy supply in developing countries. Known as the Renewable Energy Project Support Offices (REPSOs), these in-country facilities are managed by local institutions in coordination with Winrock. REPSOs provide an array of technical and financial support services to help developers identify and evaluate opportunities for renewable energy projects.

  1. The international atom

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1962-12-31

    The film explains in basic terms nuclear fission, the use of nuclear power (propulsion of ships), the production and use of radioisotopes (medicine-radioactive tracers, sterilization of instruments; agriculture-fertilizers, screw-worm elimination, irradiation of food; industry). Demonstrates international co-operation and research in the nuclear field

  2. PODAAC-SMP20-2SOCS

    Data.gov (United States)

    National Aeronautics and Space Administration — The version 2.0 SMAP-SSS, level 2C product contains the first release of the validated sea surface salinity orbital/swath data from the NASA Soil Moisture Active...

  3. The international petrochemical industry

    International Nuclear Information System (INIS)

    Chapman, K.

    1991-01-01

    The petrochemical industry occupies a crucial place in economic, strategic and political terms in the twentieth century. The author explains its growth and international distribution from the 1920s tot he present, relating the particular experience of petrochemicals to the processes that have shaped the long-term evolution of industry in general. The geographical coverage of this book extends from the regional to international scale, and its historical scope embraces one hundred years from the laboratory origins of polymer science and petrochemistry to the massive operations of modern industry. It represents the result of twenty years of research, and reflects the author's privileged access to company sources in both the U.S. and Europe

  4. The uranium International trade

    International Nuclear Information System (INIS)

    Gonzalez U, L.A.

    1993-01-01

    The aim of this thesis is the understanding of how the present dynamic of uranium International trade is developed, the variables which fall into, the factors that are affecting and conditioning it, in order to clarify which are going to be the outlook in the future of this important resource in front of the present ecological situation and the energetic panorama of XXI Century. For this purpose, as starting point, the uranium is considered as a strategic material which importance take root in its energetic potential as alternate energy source, and for this reason in Chapter I, the general problem of raw materials, its classification and present situation in the global market is presented. In Chapter II, by means of a historical review, is explain what uranium is, how it was discovered, and how since the end of the past Century and during the last three decades of present, uranium pass of practically unknown element, to the position of a strategic raw material, which by degrees, generate an International market, owing to its utilization as a basic resource in the generation of energy. Chapter III, introduce us in the roll played by uranium, since its warlike applications until its utilization in nuclear reactors for the generation of electricity. Also is explain the reason for this change in the perception at global level. Finally, in Chapter IV we enter upon specifically in the present conditions of the International market of this mineral throughout the trends of supply and demand, the main producers, users, price dynamics, and the correlation among these economical variables and other factors of political, social and ecological nature. All of these with the purpose to found out, if there exist, a meaning of the puzzle that seems to be the uranium International trade

  5. The international Chernobyl project

    International Nuclear Information System (INIS)

    1991-01-01

    This article summarizes the official report of the International Advisory Committee at the conference of the International Chernobyl Project held in Vienna, May 1991. More details will be found in the actual report, ''The International Chernobyl Project: An Overview'' (INI22:066284/5). Measurements and assessments carried out under the project provided general corroboration of the levels of surface cesium-137 contamination reported in the official maps. The project also concluded that the official procedures for estimating radiation doses to the population were scientifically sound, although they generally resulted in overestimates of two- to threefold. The project could find no marked increase in the incidence of leukemia or cancer, but reported absorbed thyroid doses in children might lead to a statistically detectable rise in the incidence of thyroid tumors. Significant non-radiation-related health disorders were found, and the accident had substantial psychological consequences in terms of anxiety and stress. The project concluded that the protective measures taken were too extreme, and that population relocation and foodstuff restrictions should have been less extensive

  6. The internal energy market

    International Nuclear Information System (INIS)

    1988-01-01

    The briefs compile the results of the studies the Commission worked out on the subject on the basis of experiences gained on its own part, on the part of the government and on the part of the market. The briefs are based on the schematic inventory annexed which for each energy sector points out the different existing or potential obstacles to a common energy market the most comprehensive and transparent way possible. Step by step part one and part two discuss the general problems connected with the integration of energy into the internal market, priorities which according to the Commission should be investigated into, and guidelines for such investigations. (orig./UA) [de

  7. Research on SEU hardening of heterogeneous Dual-Core SoC

    Science.gov (United States)

    Huang, Kun; Hu, Keliu; Deng, Jun; Zhang, Tao

    2017-08-01

    The implementation of Single-Event Upsets (SEU) hardening has various schemes. However, some of them require a lot of human, material and financial resources. This paper proposes an easy scheme on SEU hardening for Heterogeneous Dual-core SoC (HD SoC) which contains three techniques. First, the automatic Triple Modular Redundancy (TMR) technique is adopted to harden the register heaps of the processor and the instruction-fetching module. Second, Hamming codes are used to harden the random access memory (RAM). Last, a software signature technique is applied to check the programs which are running on CPU. The scheme need not to consume additional resources, and has little influence on the performance of CPU. These technologies are very mature, easy to implement and needs low cost. According to the simulation result, the scheme can satisfy the basic demand of SEU-hardening.

  8. Self-organized Criticality Model for Ocean Internal Waves

    International Nuclear Information System (INIS)

    Wang Gang; Hou Yijun; Lin Min; Qiao Fangli

    2009-01-01

    In this paper, we present a simple spring-block model for ocean internal waves based on the self-organized criticality (SOC). The oscillations of the water blocks in the model display power-law behavior with an exponent of -2 in the frequency domain, which is similar to the current and sea water temperature spectra in the actual ocean and the universal Garrett and Munk deep ocean internal wave model [Geophysical Fluid Dynamics 2 (1972) 225; J. Geophys. Res. 80 (1975) 291]. The influence of the ratio of the driving force to the spring coefficient to SOC behaviors in the model is also discussed. (general)

  9. A Framework for Hardware-Accelerated Services Using Partially Reconfigurable SoCs

    Directory of Open Access Journals (Sweden)

    MACHIDON, O. M.

    2016-05-01

    Full Text Available The current trend towards ?Everything as a Service? fosters a new approach on reconfigurable hardware resources. This innovative, service-oriented approach has the potential of bringing a series of benefits for both reconfigurable and distributed computing fields by favoring a hardware-based acceleration of web services and increasing service performance. This paper proposes a framework for accelerating web services by offloading the compute-intensive tasks to reconfigurable System-on-Chip (SoC devices, as integrated IP (Intellectual Property cores. The framework provides a scalable, dynamic management of the tasks and hardware processing cores, based on dynamic partial reconfiguration of the SoC. We have enhanced security of the entire system by making use of the built-in detection features of the hardware device and also by implementing active counter-measures that protect the sensitive data.

  10. Design of a Programmable Passive SoC for Biomedical Applications Using RFID ISO 15693/NFC5 Interface

    Directory of Open Access Journals (Sweden)

    Mayukh Bhattacharyya

    2018-01-01

    Full Text Available Low power, low cost inductively powered passive biotelemetry system involving fully customized RFID/NFC interface base SoC has gained popularity in the last decades. However, most of the SoCs developed are application specific and lacks either on-chip computational or sensor readout capability. In this paper, we present design details of a programmable passive SoC in compliance with ISO 15693/NFC5 standard for biomedical applications. The integrated system consists of a 32-bit microcontroller, a sensor readout circuit, a 12-bit SAR type ADC, 16 kB RAM, 16 kB ROM and other digital peripherals. The design is implemented in a 0.18 μ m CMOS technology and used a die area of 1.52 mm × 3.24 mm. The simulated maximum power consumption of the analog block is 592 μ W. The number of external components required by the SoC is limited to an external memory device, sensors, antenna and some passive components. The external memory device contains the application specific firmware. Based on the application, the firmware can be modified accordingly. The SoC design is suitable for medical implants to measure physiological parameters like temperature, pressure or ECG. As an application example, the authors have proposed a bioimplant to measure arterial blood pressure for patients suffering from Peripheral Artery Disease (PAD.

  11. Functional SOCS1 polymorphisms are associated with variation in obesity in whites

    DEFF Research Database (Denmark)

    Gylvin, T; Ek, J; Nolsøe, R.

    2009-01-01

    . A total of more than 8100 individuals were genotyped. RESULTS: Eight variations were identified in the 5' untranslated region (UTR) region. Two of these had allele frequencies below 1% and were not further examined. The six other variants were analysed in groups of T1D families (n = 1461 subjects) and T2D...... of both the rs33977706 and the rs243330 (-1656G > A) variants to obesity were found (p = 0.047 and p = 0.015) respectively. The rs33977706 affected both binding of a nuclear protein to and the transcriptional activity of the SOCS1 promoter, indicating a relationship between this polymorphism and gene...... regulation. CONCLUSIONS/INTERPRETATION: This study demonstrates that functional variations in the SOCS1 promoter may associate with alterations in BMI in the general white population....

  12. Daily Socs1 rhythms alter with aging differentially in peripheral clocks in male Wistar rats: therapeutic effects of melatonin.

    Science.gov (United States)

    Vinod, Ch; Jagota, Anita

    2017-06-01

    Suprachiasmatic nucleus (SCN) in synchronization with the peripheral clocks regulates the temporal oscillations leading to overt rhythms. Aging leads to attenuation of such circadian regulation, accompanied by increased inflammatory mediators prevalently the cytokines. Suppressors of cytokine signaling (SOCS) family of proteins such as SOCS 1, 3 and cytokine-inducible SH2-containing protein (CIS) negatively regulate the cytokine signaling pathway. The role of SOCS1 in aging and circadian system is obscure. We therefore studied the daily rhythms of rSocs1 mRNA expression at Zeitgeber time (ZT) -0, 6, 12 and 18 in peripheral clocks such as liver, kidney, intestine and heart of 3, 12 and 24 months (m) old male Wistar rats. Interestingly the peripheral clocks studied displayed a rhythmic rSocs1 gene expression in 3 months. In 12 months group, 12 h phase advance in liver and 12 h phase delay in kidney and heart was observed with abolition of rhythms in intestine. Aging (24 months group) resulted in a phase advance by 6 h in liver and heart with abolition of rhythms in intestine in 24 months group. Kidney was also significantly affected upon aging with significant decrease in the rSocs1 levels and abolition of rhythms. The decrease in melatonin levels with aging is associated with decreased immunity and increased oxidative stress. The exogenous administration of melatonin has been linked to play a role in re-synchronization of circadian rhythms, reducing oxidative stress and enhancing immune properties. We therefore had studied the effect of exogenous melatonin upon age induced changes in daily rSocs1 gene expression patterns. Melatonin treatment partially restored the rhythms and daily pulse (ratio of maximum:minimum levels) in liver and intestine in 12 months group. Melatonin administration resulted in a significant increase in mean 24 h rSocs1 expression in intestine and heart of 24 months group compared to that of 3 months. The melatonin administration

  13. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.

    Directory of Open Access Journals (Sweden)

    Eva-K Pauli

    2008-11-01

    Full Text Available The type I interferon (IFN system is a first line of defense against viral infections. Viruses have developed various mechanisms to counteract this response. So far, the interferon antagonistic activity of influenza A viruses was mainly observed on the level of IFNbeta gene induction via action of the viral non-structural protein 1 (NS1. Here we present data indicating that influenza A viruses not only suppress IFNbeta gene induction but also inhibit type I IFN signaling through a mechanism involving induction of the suppressor of cytokine signaling-3 (SOCS-3 protein. Our study was based on the observation that in cells that were infected with influenza A virus and subsequently stimulated with IFNalpha/beta, phosphorylation of the signal transducer and activator of transcription protein 1 (STAT1 was strongly reduced. This impaired STAT1 activation was not due to the action of viral proteins but rather appeared to be induced by accumulation of viral 5' triphosphate RNA in the cell. SOCS proteins are potent endogenous inhibitors of Janus kinase (JAK/STAT signaling. Closer examination revealed that SOCS-3 but not SOCS-1 mRNA levels increase in an RNA- and nuclear factor kappa B (NF-kappaB-dependent but type I IFN-independent manner early in the viral replication cycle. This direct viral induction of SOCS-3 mRNA and protein expression appears to be relevant for suppression of the antiviral response since in SOCS-3 deficient cells a sustained phosphorylation of STAT1 correlated with elevated expression of type I IFN-dependent genes. As a consequence, progeny virus titers were reduced in SOCS-3 deficient cells or in cells were SOCS-3 expression was knocked-down by siRNA. These data provide the first evidence that influenza A viruses suppress type I IFN signaling on the level of JAK/STAT activation. The inhibitory effect is at least in part due to the induction of SOCS-3 gene expression, which results in an impaired antiviral response.

  14. Internal audit consider the implications.

    Science.gov (United States)

    Baumgartner, Grant D; Hamilton, Angela

    2004-06-01

    Internal audit can not only allay external and internal concerns about appropriateness of business operations, but also help improve efficiency and the bottom line. To get an internal audit function under way, healthcare organizations need to obtain board buy-in, form an audit committee of the board, determine resources needed, perform a risk assessment, and develop an internal audit plan.

  15. An improved PNGV modeling and SOC estimation for lithium iron phosphate batteries

    Science.gov (United States)

    Li, Peng

    2017-11-01

    Because lithium iron phosphate battery has many advantages, it has been used more and more widely in the field of electric vehicle. The lithium iron phosphate battery, presents the improved PNGV model, and the batteries charge discharge characteristics and pulse charge discharge experiments, identification of parameters of the battery model by interpolation and least square fitting method, to achieve a more accurate modeling of lithium iron phosphate battery, and the extended Calman filter algorithm (EKF) is completed state nuclear power battery (SOC) estimate.

  16. A 0.7-V 17.4- μ W 3-lead wireless ECG SoC.

    Science.gov (United States)

    Khayatzadeh, Mahmood; Zhang, Xiaoyang; Tan, Jun; Liew, Wen-Sin; Lian, Yong

    2013-10-01

    This paper presents a fully integrated sub-1 V 3-lead wireless ECG System-on-Chip (SoC) for wireless body sensor network applications. The SoC includes a two-channel ECG front-end with a driven-right-leg circuit, an 8-bit SAR ADC, a custom-designed 16-bit microcontroller, two banks of 16 kb SRAM, and a MICS band transceiver. The microcontroller and SRAM blocks are able to operate at sub-/near-threshold regime for the best energy consumption. The proposed SoC has been implemented in a standard 0.13- μ m CMOS process. Measurement results show the microcontroller consumes only 2.62 pJ per instruction at 0.35 V . Both microcontroller and memory blocks are functional down to 0.25 V. The entire SoC is capable of working at single 0.7-V supply. At the best case, it consumes 17.4 μ W in heart rate detection mode and 74.8 μW in raw data acquisition mode under sampling rate of 500 Hz. This makes it one of the best ECG SoCs among state-of-the-art biomedical chips.

  17. 0.45 v and 18 μA/MHz MCU SOC with Advanced Adaptive Dynamic Voltage Control (ADVC

    Directory of Open Access Journals (Sweden)

    Uzi Zangi

    2018-05-01

    Full Text Available An ultra-low-power MicroController Unit System-on-Chip (MCU SOC is described with integrated DC to DC power management and Adaptive Dynamic Voltage Control (ADVC mechanism. The SOC, designed and fabricated in a 40 nm ULP standard CMOS technology, includes the complete Synopsys ARC EM5D core MCU, featuring a full set of DSP instructions and minimizing energy consumption at a wide range of frequencies: 312 K–80 MHz. A number of unique low voltage digital libraries, comprising of approximately 300 logic cells and sequential elements, were used for the MCU SOC design. On-die silicon sensors were utilized to continuously change the operating voltage to optimize power/performance for a given frequency and environmental conditions, and also to resolve yield and life time problems, while operating at low voltages. A First Fail (FFail mechanism, which can be digitally and linearly controlled with up to 8 bits, detects the failing SOC voltage at a given frequency. The core operates between 0.45–1.1 V volts with a direct battery connection for an input voltage of 1.6–3.6 V. Measurement results show that the peak energy efficiency is 18μW/MHz. A comparison to state-of-the-art commercial SOCs is presented, showing a 3–5× improved current/DMIPS (Dhrystone Million Instructions per second compared to the next best chip.

  18. Transport-distance specific SOC distribution: Does it skew erosion induced C fluxes?

    DEFF Research Database (Denmark)

    Hu, Yaxian; Berbe, Asmerat Asefaw; Fogel, Marilyn L.

    2016-01-01

    Abstract The net effect of soil erosion by water, as a sink or source of atmospheric carbon dioxide (CO2), is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC), and the dynamic replacement of eroded C by the production of new photosynthate. The depositi......Abstract The net effect of soil erosion by water, as a sink or source of atmospheric carbon dioxide (CO2), is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC), and the dynamic replacement of eroded C by the production of new photosynthate...... the actual movement of eroded soil fractions along hillslopes, let alone the re-distribution pattern of SOC fractions. Eroding sandy soils and sediment were sampled after a series of rainfall events along a slope on a freshly seeded cropland in Jutland, Denmark. All the soil samples were fractionated...... into five settling classes using a settling tube apparatus. The spatial distribution of soil settling classes shows a coarsening effect immediately below the eroding slope, followed by a fining trend at the slope tail. These findings support the validity of the conceptual model proposed by Starr et al...

  19. Functional network analysis of genes differentially expressed during xylogenesis in soc1ful woody Arabidopsis plants.

    Science.gov (United States)

    Davin, Nicolas; Edger, Patrick P; Hefer, Charles A; Mizrachi, Eshchar; Schuetz, Mathias; Smets, Erik; Myburg, Alexander A; Douglas, Carl J; Schranz, Michael E; Lens, Frederic

    2016-06-01

    Many plant genes are known to be involved in the development of cambium and wood, but how the expression and functional interaction of these genes determine the unique biology of wood remains largely unknown. We used the soc1ful loss of function mutant - the woodiest genotype known in the otherwise herbaceous model plant Arabidopsis - to investigate the expression and interactions of genes involved in secondary growth (wood formation). Detailed anatomical observations of the stem in combination with mRNA sequencing were used to assess transcriptome remodeling during xylogenesis in wild-type and woody soc1ful plants. To interpret the transcriptome changes, we constructed functional gene association networks of differentially expressed genes using the STRING database. This analysis revealed functionally enriched gene association hubs that are differentially expressed in herbaceous and woody tissues. In particular, we observed the differential expression of genes related to mechanical stress and jasmonate biosynthesis/signaling during wood formation in soc1ful plants that may be an effect of greater tension within woody tissues. Our results suggest that habit shifts from herbaceous to woody life forms observed in many angiosperm lineages could have evolved convergently by genetic changes that modulate the gene expression and interaction network, and thereby redeploy the conserved wood developmental program. © 2016 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.

  20. Parametric dense stereovision implementation on a system-on chip (SoC).

    Science.gov (United States)

    Gardel, Alfredo; Montejo, Pablo; García, Jorge; Bravo, Ignacio; Lázaro, José L

    2012-01-01

    This paper proposes a novel hardware implementation of a dense recovery of stereovision 3D measurements. Traditionally 3D stereo systems have imposed the maximum number of stereo correspondences, introducing a large restriction on artificial vision algorithms. The proposed system-on-chip (SoC) provides great performance and efficiency, with a scalable architecture available for many different situations, addressing real time processing of stereo image flow. Using double buffering techniques properly combined with pipelined processing, the use of reconfigurable hardware achieves a parametrisable SoC which gives the designer the opportunity to decide its right dimension and features. The proposed architecture does not need any external memory because the processing is done as image flow arrives. Our SoC provides 3D data directly without the storage of whole stereo images. Our goal is to obtain high processing speed while maintaining the accuracy of 3D data using minimum resources. Configurable parameters may be controlled by later/parallel stages of the vision algorithm executed on an embedded processor. Considering hardware FPGA clock of 100 MHz, image flows up to 50 frames per second (fps) of dense stereo maps of more than 30,000 depth points could be obtained considering 2 Mpix images, with a minimum initial latency. The implementation of computer vision algorithms on reconfigurable hardware, explicitly low level processing, opens up the prospect of its use in autonomous systems, and they can act as a coprocessor to reconstruct 3D images with high density information in real time.

  1. The internal percolation problem

    International Nuclear Information System (INIS)

    Bezsudnov, I.V.; Snarskii, A.A.

    2010-01-01

    The internal percolation problem (IP) as a new type of the percolation problem is introduced and investigated. In spite of the usual (or external) percolation problem (EP) when the percolation current flows from the top to the bottom of the system, in IP case the voltage is applied through bars which are present in the hole located within the system. The EP problem has two major parameters: M-size of the system and a 0 -size of inclusions, bond size, etc. The IP problem holds one parameter more: size of the hole L. Numerical simulation shows that the critical indexes of conductance for the IP problem are very close to those in the EP problem. On the contrary, the indexes of the relative spectral noise density of 1/f noise and higher moments differ from those in the EP problem. The basics of these facts is discussed.

  2. A Cryptographic SoC for Robust Protection of Secret Keys in IPTV DRM Systems

    Science.gov (United States)

    Lee, Sanghan; Yang, Hae-Yong; Yeom, Yongjin; Park, Jongsik

    The security level of an internet protocol television (IPTV) digital right management (DRM) system ultimately relies on protection of secret keys. Well known devices for the key protection include smartcards and battery backup SRAMs (BB-SRAMs); however, these devices could be vulnerable to various physical attacks. In this paper, we propose a secure and cost-effective design of a cryptographic system on chip (SoC) that integrates the BB-SRAM with a cell-based design technique. The proposed SoC provides robust safeguard against the physical attacks, and satisfies high-speed and low-price requirements of IPTV set-top boxes. Our implementation results show that the maximum encryption rate of the SoC is 633Mb/s. In order to verify the data retention capabilities, we made a prototype chip using 0.18µm standard cell technology. The experimental results show that the integrated BB-SRAM can reliably retain data with a 1.4µA leakage current.

  3. The international hydrocoin project

    International Nuclear Information System (INIS)

    1988-01-01

    The international co-operation project HYDROCOIN for studying groundwater flow modelling in the context of radioactive waste disposal was initiated in 1984. Thirteen organizations from ten countries and two international organizations participate in the project which is managed by the Swedish Nuclear Power Inspectorate SKI. This report summarizes the results from the first phase of HYDROCOIN. Level 1, which has been devoted to verification of 29 computer programs for groundwater hydrology. This has been done by applying the codes to seven hypothetical test cases representing different physical situations. For linear test cases, the agreement between results calculated with different codes has been satisfactory for primarily calculated entities (groundwater pressure, salt concentration and temperatures). Results for properties derived from gradients of the primary field (groundwater velocity and trajectories) show agreement to a lesser extent. Furthermore, HYDROCOIN Level 1 illustrates problems related to solving strongly non-linear cases, such as coupled flow and brine transport. HYDROCOIN Level 1 has provided an efficient means for testing strengths and weaknesses of various strategies for groundwater flow modelling and post processing. As a result of the Level 1 effort, several code enhancements have been made

  4. Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance.

    Science.gov (United States)

    Tellechea, M L; Steinhardt, A Penas; Rodriguez, G; Taverna, M J; Poskus, E; Frechtel, G

    2013-05-01

    Specific Suppressor of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (p = 0.005) and abdominal obesity (p = 0.002) and allele C carriers showed, in comparison with TT carriers, lower BMI (p = 0.001) and waist circumference (p = 0.001). rs8074124CC- carriers showed lower fasting insulin (p = 0.017) and HOMA-IR (p = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (p = 0.009) and hypertriglyceridemic waist (p = 0.006). rs12051836CC- carriers showed lower fasting insulin (p = 0.043) and HOMA-IR (p = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (p = 0.026) and HDL-C (p = 0.014) as a continuous variable. We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders. Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

  5. A configurable and low-power mixed signal SoC for portable ECG monitoring applications.

    Science.gov (United States)

    Kim, Hyejung; Kim, Sunyoung; Van Helleputte, Nick; Artes, Antonio; Konijnenburg, Mario; Huisken, Jos; Van Hoof, Chris; Yazicioglu, Refet Firat

    2014-04-01

    This paper describes a mixed-signal ECG System-on-Chip (SoC) that is capable of implementing configurable functionality with low-power consumption for portable ECG monitoring applications. A low-voltage and high performance analog front-end extracts 3-channel ECG signals and single channel electrode-tissue-impedance (ETI) measurement with high signal quality. This can be used to evaluate the quality of the ECG measurement and to filter motion artifacts. A custom digital signal processor consisting of 4-way SIMD processor provides the configurability and advanced functionality like motion artifact removal and R peak detection. A built-in 12-bit analog-to-digital converter (ADC) is capable of adaptive sampling achieving a compression ratio of up to 7, and loop buffer integration reduces the power consumption for on-chip memory access. The SoC is implemented in 0.18 μm CMOS process and consumes 32 μ W from a 1.2 V while heart beat detection application is running, and integrated in a wireless ECG monitoring system with Bluetooth protocol. Thanks to the ECG SoC, the overall system power consumption can be reduced significantly.

  6. The international Chernobyl project

    International Nuclear Information System (INIS)

    Gonzalez, A.J.

    1992-01-01

    The findings of the International Chernobyl Project are summarized herewith. The project focused on four key issues related to the radiological consequences of the Chernobyl accident which are of concern to the population and policy makers: the true extent of the current contamination in inhabited areas of Belarus, Russia and the Ukraine; the past, current and future radiation exposure of the population; the actual and potential health effects; and the adequacy or measures being taken to protect the public. The project findings are expected to contribute towards alleviating the consequences of the accident by presenting factual information to allow future policy and worldwide assistance to be channelled to where it is most needed and where it can be best used. (author)

  7. SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced Inflammation In Vivo

    Directory of Open Access Journals (Sweden)

    João Antônio Chaves de Souza

    2013-01-01

    Full Text Available SOCS3 is an inducible endogenous negative regulator of JAK/STAT pathway, which is relevant in inflammatory conditions. We used a model of LPS-induced periodontal disease in rats to correlate SOCS3 expression with the inflammatory status. In vitro we used a murine macrophage cell line to assess the physical interaction between SOCS3 and STAT3 by coimmunoprecipitation. 30 ug of LPS from Escherichia coli were injected in the gingival tissues on the palatal aspect of first molars of the animals 3x/week for up to 4 weeks. Control animals were injected with the vehicle (PBS. The rats were sacrificed at 7, 15, and 30 days. Inflammation and gene expression were assessed by stereometric analysis, immunohistochemistry, RT-qPCR, and western blot. LPS injections increased inflammation, paralleled by an upregulation of SOCS3, of the proinflammatory cytokines IL-1β, IL-6, and TNF-α and increased phosphorylation of STAT3 and p38 MAPK. SOCS3 expression accompanied the severity of inflammation and the expression of proinflammatory cytokines, as well as the activation status of STAT3 and p38 MAPK. LPS stimulation in a macrophage cell line in vitro induced transient STAT3 activation, which was inversely correlated with a dynamic physical interaction with SOCS3, suggesting that this may be a mechanism for SOCS3 regulatory function.

  8. The International multilateral relationships

    International Nuclear Information System (INIS)

    Asty, M.; Lacoste, A.C.; Gauvain, J.; Scherrer, J.; Baer, A.J.; Thiebaud, Ph.; Delattre, D.; Domaratzki, Z.; Pretre, S.; Serviere, G.; Currie, J.; Martin, A.; Bye, R.; Williams, L.; Lacoste, A.C.

    2000-01-01

    Great multilateral organizations, at the end of the fifties to promote nuclear energy for peaceful uses, made structures in charge of promoting the exchanges in the field of safety. The Safety Authority takes part in numerous activities of these organisms with the double objective to know the practices of other ones and to make their own practices known. However, its limited means oblige to make choices among these ones that are proposed, on taking into account the specificities of each organism and on seeing not to be implied in promoting activities for nuclear energy. After the Chernobyl accident, the international community needed to conclude incentive conventions reminding of the liabilities of states in matter of nuclear safety. The first meeting of contracting parts at the Convention on nuclear safety in april 1999 has shown the high level of opening in which the countries considered their obligations. (N.C.)

  9. Factors Affecting the Internal Audit Effectiveness

    OpenAIRE

    Mustika, Adhista Cahya

    2015-01-01

    This study tests the factors that influence the internal audit effectiveness, including internal auditor competencies, internal auditor independence, auditee support to internal audit activity, and the internal and external auditor relationship. Using the internal auditor inspectorate in Java Province, Indonesia, we found that the internal audit effectiveness can be attained through increase internal audit competence, independence and strong relationship between internal and external auditor....

  10. Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector

    International Nuclear Information System (INIS)

    Zhou Hongsheng; Zhang Donghua; Wang Yaya; Dai Ming; Zhang Lu; Liu Wenli; Liu Dan; Tan Huo; Huang Zhenqian

    2006-01-01

    CML28 is an attractive target for antigen-specific immunotherapy. SOCS1 represents an inhibitory control mechanism for DC antigen presentation and the magnitude of adaptive immunity. In this study, we evaluated the potential for inducing CML28-specific cytotoxic T lymphocytes (CTL) responses by dendritic cells (DCs)-based vaccination. We constructed a CML28 DNA vaccine and a SOCS1 siRNA vector and then cotransfect monocyte-derived DCs. Flow cytometry analysis showed gene silencing of SOCS1 resulted in higher expressions of costimulative moleculars in DCs. Mixed lymphocyte reaction (MLR) indicated downregulation of SOCS1 stronger capability to stimulate proliferation of responder cell in DCs. The CTL assay revealed transfected DCs effectively induced autologous CML28-specific CTL responses and the lytic activities induced by SOCS1-silenced DCs were significantly higher compared with those induced by SOCS1-expressing DCs. These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs

  11. Inducibility of STAT 1/SOCS 3 transcripts and proteins by interferon-alpha/gamma in human melanoma cell lines

    Czech Academy of Sciences Publication Activity Database

    Kovařík, Aleš; Fojtová, Miloslava; Boudný, V.; Adamková, L.; Kovařík, J.

    2004-01-01

    Roč. 14, Suppl. 1 (2004), s. S87 ISSN 1107-3756. [World Congress on Advances in Oncology /9./ and International Symposium on Molecular Medicine /7./. 14.10.2004-16.10.2004, Hersonissos] R&D Projects: GA MZd NC7139; GA ČR GA301/03/0370; GA AV ČR IBS5004010 Keywords : melanoma cells * STAT 1 * SOCS 3 Subject RIV: BO - Biophysics

  12. The International Linear Collider

    Directory of Open Access Journals (Sweden)

    List Benno

    2014-04-01

    Full Text Available The International Linear Collider (ILC is a proposed e+e− linear collider with a centre-of-mass energy of 200–500 GeV, based on superconducting RF cavities. The ILC would be an ideal machine for precision studies of a light Higgs boson and the top quark, and would have a discovery potential for new particles that is complementary to that of LHC. The clean experimental conditions would allow the operation of detectors with extremely good performance; two such detectors, ILD and SiD, are currently being designed. Both make use of novel concepts for tracking and calorimetry. The Japanese High Energy Physics community has recently recommended to build the ILC in Japan.

  13. The International Linear Collider

    Science.gov (United States)

    List, Benno

    2014-04-01

    The International Linear Collider (ILC) is a proposed e+e- linear collider with a centre-of-mass energy of 200-500 GeV, based on superconducting RF cavities. The ILC would be an ideal machine for precision studies of a light Higgs boson and the top quark, and would have a discovery potential for new particles that is complementary to that of LHC. The clean experimental conditions would allow the operation of detectors with extremely good performance; two such detectors, ILD and SiD, are currently being designed. Both make use of novel concepts for tracking and calorimetry. The Japanese High Energy Physics community has recently recommended to build the ILC in Japan.

  14. Performance Evaluation of FIR Filter After Implementation on Different FPGA and SOC and Its Utilization in Communication and Network

    DEFF Research Database (Denmark)

    Pandey, Bishwajeet; Das, Bhagwan; Kaur, Amanpreet

    2017-01-01

    that will energy efficient as well as faster than traditional design. Three different FPGA and SOC are taken under consideration and our design is implemented on these four ICs and we find the most energy efficient architecture and also find the architecture that will deliver highest performance among these four...... FPGA then we conclude that Zynq 7000 All programmable SOC is power hungry architecture and Kintex ultrascale architecture is the most energy efficient architecture that dissipates 20.86% less power than Zynq 700 All programmable SOC. For performance evaluation, we have taken benchmark C code of FIR...... provide by Xilinx. We transform that C code into HDL using Vivado HLS 2016.2 before power analysis on Vivado 2016.2. Ultrascale FPGA is generally used for packet processing in 100G networking and heterogeneous wireless infrastructure....

  15. Suppressor of cytokine signaling 2 (Socs2 deletion protects bone health of mice with DSS-induced inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Ross Dobie

    2018-01-01

    Full Text Available Individuals with inflammatory bowel disease (IBD often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying cellular mechanisms. Although bone loss in IBD is multifactorial, the altered sensitivity and secretion of growth hormone (GH and insulin-like growth factor-1 (IGF-1 in IBD is understood to be a critical contributing mechanism. The expression of suppressor of cytokine signaling 2 (SOCS2, a well-established negative regulator of GH signaling, is stimulated by proinflammatory cytokines. Therefore, it is likely that SOCS2 expression represents a critical mediator through which proinflammatory cytokines inhibit GH/IGF-1 signaling and decrease bone quality in IBD. Using the dextran sodium sulfate (DSS model of colitis, we reveal that endogenously elevated GH function in the Socs2−/− mouse protects the skeleton from osteopenia. Micro-computed tomography assessment of DSS-treated wild-type (WT mice revealed a worsened trabecular architecture compared to control mice. Specifically, DSS-treated WT mice had significantly decreased bone volume, trabecular thickness and trabecular number, and a resulting increase in trabecular separation. In comparison, the trabecular bone of Socs2-deficient mice was partially protected from the adverse effects of DSS. The reduction in a number of parameters, including bone volume, was less, and no changes were observed in trabecular thickness or separation. This protected phenotype was unlikely to be a consequence of improved mucosal health in the DSS-treated Socs2−/− mice but rather a result of unregulated GH signaling directly on bone. These studies indicate that the absence of SOCS2 is protective against bone loss typical of IBD. This study also provides an improved understanding of the relative effects of GH/IGF-1 signaling on bone health in experimental colitis, information that is essential before these drugs are

  16. DMPD: Regulation of cytokine signaling by SOCS family molecules. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 14644140 Regulation of cytokine signaling by SOCS family molecules. Fujimoto M, Nak...a T. Trends Immunol. 2003 Dec;24(12):659-66. (.png) (.svg) (.html) (.csml) Show Regulation of cytokine signaling by SOCS family... molecules. PubmedID 14644140 Title Regulation of cytokine signaling by SOCS family molec

  17. Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity.

    Science.gov (United States)

    Ali, Omar; Cerjak, Diana; Kent, Jack W; James, Roland; Blangero, John; Carless, Melanie A; Zhang, Yi

    2016-09-01

    Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. We assessed the relationship between DNA methylation and obesity in peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across the genome in family members (8-90 y of age) using a discovery cohort (192 individuals) and a validation cohort (1,052 individuals) of Northern European ancestry. After Bonferroni-correction (P α=0.05 = 1.31 × 10 -7 ) for genome-wide significance, we identified 3 loci, cg18181703 (SOCS3), cg04502490 (ZNF771), and cg02988947 (LIMD2), where methylation status was associated with body mass index percentile (BMI%), a clinical index for obesity in children, adolescents, and adults. These sites were also associated with multiple metabolic syndrome (MetS) traits, including central obesity, fat depots, insulin responsiveness, and plasma lipids. The SOCS3 methylation locus was also associated with the clinical definition of MetS. In the validation cohort, SOCS3 methylation status was found to be inversely associated with BMI% (P = 1.75 × 10 -6 ), waist to height ratio (P = 4.18 × 10 -7 ), triglycerides (P = 4.01 × 10 -4 ), and MetS (P = 4.01 × 10 -7 ), and positively correlated with HDL-c (P = 4.57 × 10 -8 ). Functional analysis in a sub cohort (333 individuals) demonstrated SOCS3 methylation and gene expression in PBMCs were inversely correlated (P = 2.93 × 10 -4 ) and expression of SOCS3 was positively correlated with status of MetS (P = 0.012). We conclude that epigenetic modulation of SOCS3, a gene involved in leptin and insulin signaling, may play an important role in obesity and MetS.

  18. Language and the International Context

    Science.gov (United States)

    Tonkin, Humphrey

    1977-01-01

    A discussion of the issue of unilinguism and linguistic pluralism on the international scene. The need for international communication where English is the dominant force and efforts to preserve cultural equality are seen as compelling reasons for promotion of an international language such as Esperanto. (AMH)

  19. The international hydrocoin project

    International Nuclear Information System (INIS)

    1987-01-01

    The International HYDROCOIN (Hydrologic Code Intercomparison) Project was started in May 1984. Fourteen organizations participate in the Project, with the Swedish Nuclear Power Inspectorate (SKI) as managing participant and the OECD Nuclear Energy Agency (NEA) taking part as a member of the Project secretariat. HYDROCOIN is concerned with the assessment of groundwater movements at potential nuclear waste disposal sites with the help of mathematical models and computer codes. The Project is divided into three levels. The objective of HYDROCOIN Level 1 is to verify the accuracy of groundwater flow codes. HYDROCOIN Level 2 and Level 3 are concerned with validation of hydrological models and uncertainty/sensitivity analysis, respectively. This report, which has been prepared by the NEA Secretariat and SKI in consultation with the co-ordinating group of the HYDROCOIN Project summarizes the background and objectives of the Project and presents the results of the work performed up to the middle of 1987. It is intended to provide general information on HYDROCOIN to interested parties beyond the group of directly involved specialists

  20. The Development of Customary International Law by International Organizations

    DEFF Research Database (Denmark)

    Odermatt, Jed

    2017-01-01

    In his Fourth Report on the Identification of Customary International Law (2016), Special Rapporteur Michael Wood confirmed that ‘[i]n certain cases, the practice of international organizations also contributes to the expression, or creation, of rules of customary international law.......’ That the practice of international organizations can be relevant when identifying customary international law is relatively uncontroversial. The practice of states within international organizations such as the UN General Assembly, for example, may contribute to the development of custom. Yet, there is little...... discussion about whether and how the practice of international organizations as such may contribute to the development of customary international law. This contribution discusses the organization that is the most capable of contributing to the development of customary international law in its own right...

  1. The international law commission and international environmental law

    International Nuclear Information System (INIS)

    Ramcharan, B.G.

    1975-01-01

    If the oceans are destroyed through pollution there will be nothing left to manage. Protection against pollution is thus a fundamental aspect of ocean management. What legal principles are available for the protection of the oceans. This paper brings together the relevant practice of the foremost international body responsible for the codification and development of international law: the International Law Commission. It describes the work of the Commission concerning: 1) pollution of the high seas; 2) pollution of international watercourses; and 3) international responsibility for environmental hazards. It concludes by expressing the hope that the Commission will further study, codify and develop international environmental law

  2. The International Active Learning Space

    DEFF Research Database (Denmark)

    Manners, Ian James

    2015-01-01

    -Danish students receive the basic international and intercultural skills and knowledge they need in current society. The English-language masters’ seminars I teach at the Department of Political Science are international in terms of students and teacher, but they are also Active Learning seminars......-Danish students (and sometimes teachers) rarely speak to each other or learn each other’s names. In the international AL spaces I create, students must work together on joint tasks which require interaction to address tasks and integration in order to benefit from the multinational activity groups. Planning AL...... that complete the seminar soon become vocal advocates of international AL. Ultimately, enriching student learning through immersing Danish and international students in an international AL space is, for me, the best way of ensuring an internationalised learning outcome, rather than just international mobility....

  3. Online cell SOC estimation of Li-ion battery packs using a dual time-scale Kalman filtering for EV applications

    International Nuclear Information System (INIS)

    Dai, Haifeng; Wei, Xuezhe; Sun, Zechang; Wang, Jiayuan; Gu, Weijun

    2012-01-01

    Highlights: ► We use an equivalent circuit model to describe the characteristics of battery. ► A dual time-scale estimator is used to calculate pack average SOC and cell SOC. ► The estimator is based on the dynamic descriptions and extended Kalman filter. ► Three different test cases are designed to validate the proposed method. ► Test results indicate a good performance of the method for EV applications. -- Abstract: For the vehicular operation, due to the voltage and power/energy requirements, the battery systems are usually composed of up to hundreds of cells connected in series or parallel. To accommodate the operation conditions, the battery management system (BMS) should estimate State of Charge (SOC) to facilitate safe and efficient utilization of the battery. The performance difference among the cells makes a pure pack SOC estimation hardly provide sufficient information, which at last affects the computation of available energy and power and the safety of the battery system. So for a reliable and accurate management, the BMS should “know” the SOC of each individual cell. Several possible solutions on this issue have been reported in the recent years. This paper studies a method to determine online all individual cell SOCs of a series-connected battery pack. This method, with an equivalent circuit based “averaged cell” model, estimates the battery pack’s average SOC first, and then incorporates the performance divergences between the “averaged cell” and each individual cell to generate the SOC estimations for all cells. This method is developed based on extended Kalman filter (EKF), and to reduce the computation cost, a dual time-scale implementation is designed. The method is validated using results obtained from the measurements of a Li-ion battery pack under three different tests, and analysis indicates the good performance of the algorithm.

  4. Effects of land use change and management on SOC and soil quality in Mediterranean rangelands areas

    Science.gov (United States)

    Parras-Alcántara, Luis; Lozano-García, Beatriz; Requejo, Ana; Zornoza, Raúl

    2017-04-01

    INTRODUCTION Rangelands in the Iberian Peninsula occupy more than 90,000 km2. These rangelands were created from the former Mediterranean oak forests, mainly composed of holm oak and cork oak (Quercus ilex rotundifolia and Quercus suber), by clear-cutting shrubs, removing selected trees and cultivating. These man-made landscapes are called 'dehesas' in Spain and 'montados' in Portugal. Between 1955 and 1981, more than 5,000 km2 of dehesas was converted from pastureland to cultivated land. This process has been accelerated since 1986 owing to subsidies from the European Common Agricultural Policy (Parras-Alcántara et al., 2015a). The role that natural rangelands play in the global carbon cycle is extremely important, accounting for 10-30% of the world's total soil organic carbon (SOC), in addition, SOC concentration is closely related to soil quality and vegetation productivity (Brevik, 2012). Therefore, to study the land use and management changes is important, particularly in Mediterranean soils, as they are characterized by low organic carbon content, furthermore, the continuous use of ploughing for grain production is the principal cause of soil degradation. Therefore, land use decisions and management systems can increase or decrease SOC content and stock (Corral-Fernández et al., 2013; Parras-Alcántara et al., 2014, 2015a and 2015b; Parras-Alcántara and Lozano-García, 2014) MATERIAL AND METHODS A field study was conducted to determine the land use change (Mediterranean evergreen oak woodland to olive grove and cereal, all of them managed under conventional tillage and under conservationist practices) effects on SOC stocks and the soil quality (Stratification Ratio) in Los Pedroches valley, southern Spain. RESULTS Results for the present study indicate that management practices had little effect on SOC storage in dehesas. The stratification ratio was >2 both under conventional tillage and under organic farming, so, soils under dehesa had high quality

  5. High organic inputs explain shallow and deep SOC storage in a long-term agroforestry system – combining experimental and modeling approaches

    Directory of Open Access Journals (Sweden)

    R. Cardinael

    2018-01-01

    Full Text Available Agroforestry is an increasingly popular farming system enabling agricultural diversification and providing several ecosystem services. In agroforestry systems, soil organic carbon (SOC stocks are generally increased, but it is difficult to disentangle the different factors responsible for this storage. Organic carbon (OC inputs to the soil may be larger, but SOC decomposition rates may be modified owing to microclimate, physical protection, or priming effect from roots, especially at depth. We used an 18-year-old silvoarable system associating hybrid walnut trees (Juglans regia  ×  nigra and durum wheat (Triticum turgidum L. subsp. durum and an adjacent agricultural control plot to quantify all OC inputs to the soil – leaf litter, tree fine root senescence, crop residues, and tree row herbaceous vegetation – and measured SOC stocks down to 2 m of depth at varying distances from the trees. We then proposed a model that simulates SOC dynamics in agroforestry accounting for both the whole soil profile and the lateral spatial heterogeneity. The model was calibrated to the control plot only. Measured OC inputs to soil were increased by about 40 % (+ 1.11 t C ha−1 yr−1 down to 2 m of depth in the agroforestry plot compared to the control, resulting in an additional SOC stock of 6.3 t C ha−1 down to 1 m of depth. However, most of the SOC storage occurred in the first 30 cm of soil and in the tree rows. The model was strongly validated, properly describing the measured SOC stocks and distribution with depth in agroforestry tree rows and alleys. It showed that the increased inputs of fresh biomass to soil explained the observed additional SOC storage in the agroforestry plot. Moreover, only a priming effect variant of the model was able to capture the depth distribution of SOC stocks, suggesting the priming effect as a possible mechanism driving deep SOC dynamics. This result questions the potential of soils to

  6. High organic inputs explain shallow and deep SOC storage in a long-term agroforestry system - combining experimental and modeling approaches

    Science.gov (United States)

    Cardinael, Rémi; Guenet, Bertrand; Chevallier, Tiphaine; Dupraz, Christian; Cozzi, Thomas; Chenu, Claire

    2018-01-01

    Agroforestry is an increasingly popular farming system enabling agricultural diversification and providing several ecosystem services. In agroforestry systems, soil organic carbon (SOC) stocks are generally increased, but it is difficult to disentangle the different factors responsible for this storage. Organic carbon (OC) inputs to the soil may be larger, but SOC decomposition rates may be modified owing to microclimate, physical protection, or priming effect from roots, especially at depth. We used an 18-year-old silvoarable system associating hybrid walnut trees (Juglans regia × nigra) and durum wheat (Triticum turgidum L. subsp. durum) and an adjacent agricultural control plot to quantify all OC inputs to the soil - leaf litter, tree fine root senescence, crop residues, and tree row herbaceous vegetation - and measured SOC stocks down to 2 m of depth at varying distances from the trees. We then proposed a model that simulates SOC dynamics in agroforestry accounting for both the whole soil profile and the lateral spatial heterogeneity. The model was calibrated to the control plot only. Measured OC inputs to soil were increased by about 40 % (+ 1.11 t C ha-1 yr-1) down to 2 m of depth in the agroforestry plot compared to the control, resulting in an additional SOC stock of 6.3 t C ha-1 down to 1 m of depth. However, most of the SOC storage occurred in the first 30 cm of soil and in the tree rows. The model was strongly validated, properly describing the measured SOC stocks and distribution with depth in agroforestry tree rows and alleys. It showed that the increased inputs of fresh biomass to soil explained the observed additional SOC storage in the agroforestry plot. Moreover, only a priming effect variant of the model was able to capture the depth distribution of SOC stocks, suggesting the priming effect as a possible mechanism driving deep SOC dynamics. This result questions the potential of soils to store large amounts of carbon, especially at depth. Deep

  7. Detecting small-scale spatial differences and temporal dynamics of soil organic carbon (SOC) stocks: a comparison between automatic chamber-derived C budgets and repeated soil inventories

    Science.gov (United States)

    Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Juana; Albiac Borraz, Elisa; Schmidt, Marten; Huth, Vytas; Rogasik, Helmut; Rieckh, Helene; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

    2017-04-01

    Carbon (C) sequestration in soils plays a key role in the global C cycle. It is therefore crucial to adequately monitor dynamics in soil organic carbon (ΔSOC) stocks when aiming to reveal underlying processes and potential drivers. However, small-scale spatial and temporal changes in SOC stocks, particularly pronounced on arable lands, are hard to assess. The main reasons for this are limitations of the well-established methods. On the one hand, repeated soil inventories, often used in long-term field trials, reveal spatial patterns and trends in ΔSOC but require a longer observation period and a sufficient number of repetitions. On the other hand, eddy covariance measurements of C fluxes towards a complete C budget of the soil-plant-atmosphere system may help to obtain temporal ΔSOC patterns but lack small-scale spatial resolution. To overcome these limitations, this study presents a reliable method to detect both short-term temporal as well as small-scale spatial dynamics of ΔSOC. Therefore, a combination of automatic chamber (AC) measurements of CO2 exchange and empirically modeled aboveground biomass development (NPPshoot) was used. To verify our method, results were compared with ΔSOC observed by soil resampling. AC measurements were performed from 2010 to 2014 under a silage maize/winter fodder rye/sorghum-Sudan grass hybrid/alfalfa crop rotation at a colluvial depression located in the hummocky ground moraine landscape of NE Germany. Widespread in large areas of the formerly glaciated Northern Hemisphere, this depression type is characterized by a variable groundwater level (GWL) and pronounced small-scale spatial heterogeneity in soil properties, such as SOC and nitrogen (Nt). After monitoring the initial stage during 2010, soil erosion was experimentally simulated by incorporating topsoil material from an eroded midslope soil into the plough layer of the colluvial depression. SOC stocks were quantified before and after soil manipulation and at the end

  8. International activities of the GRS

    International Nuclear Information System (INIS)

    Antoni, R.; Hachenberg, G.; Schally, P.

    1990-01-01

    The individual activities fall into three main subject areas, each with differing objectives and functions: Cooperation in multilateral and bilateral bodies and organizations, cooperation in international research projects, performance of safety analyses. In addition to describing the international activities of GRS, the paper also shows how complexly interwoven the safety of nuclear facilities is at the international level, and how varied initiatives are required in order to ensure effective cooperation in the various fields. (orig.) [de

  9. International migration and the gender

    OpenAIRE

    Koropecká, Markéta

    2010-01-01

    My bachelor thesis explores the connection between international migration and gender. Gender, defined as a social, not a biological term, has a huge impact on the migration process. Statistics and expert studies that have been gender sensitive since 1970s demonstrate that women form half of the amount of the international migrants depending on the world region and representing a wide range of the kinds of international migration: family formation and reunification, labour migration, illegal ...

  10. Comparison Study on Two Model-Based Adaptive Algorithms for SOC Estimation of Lithium-Ion Batteries in Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Yong Tian

    2014-12-01

    Full Text Available State of charge (SOC estimation is essential to battery management systems in electric vehicles (EVs to ensure the safe operations of batteries and providing drivers with the remaining range of the EVs. A number of estimation algorithms have been developed to get an accurate SOC value because the SOC cannot be directly measured with sensors and is closely related to various factors, such as ambient temperature, current rate and battery aging. In this paper, two model-based adaptive algorithms, including the adaptive unscented Kalman filter (AUKF and adaptive slide mode observer (ASMO are applied and compared in terms of convergence behavior, tracking accuracy, computational cost and estimation robustness against parameter uncertainties of the battery model in SOC estimation. Two typical driving cycles, including the Dynamic Stress Test (DST and New European Driving Cycle (NEDC are applied to evaluate the performance of the two algorithms. Comparison results show that the AUKF has merits in convergence ability and tracking accuracy with an accurate battery model, while the ASMO has lower computational cost and better estimation robustness against parameter uncertainties of the battery model.

  11. Mechanism of the entire overdischarge process and overdischarge-induced internal short circuit in lithium-ion batteries.

    Science.gov (United States)

    Guo, Rui; Lu, Languang; Ouyang, Minggao; Feng, Xuning

    2016-07-22

    Lithium-ion batteries connected in series are prone to be overdischarged. Overdischarge results in various side effects, such as capacity degradation and internal short circuit (ISCr). However, most of previous research on the overdischarge of a cell was terminated when the cell voltage dropped to 0 V, leaving the further impacts of overdischarge unclear. This paper investigates the entire overdischarge process of large-format lithium-ion batteries by discharging the cell to -100% state of charge (SOC). A significant voltage platform is observed at approximately -12% SOC, and ISCr is detected after the cell is overdischarged when passing the platform. The scanning electron microscopy (SEM) and X-ray diffraction (XRD) results indicate that the overdischarge-induced ISCr is caused by Cu deposition on electrodes, suggesting possible Cu collector dissolution at the voltage platform near -12% SOC. A prognostic/mechanistic model considering ISCr is used to evaluate the resistance of ISCr (RISCr), the value of which decreases sharply at the beginning of ISCr formation. Inducing the ISCr by overdischarge is effective and well controlled without any mechanical deformation or the use of a foreign substance.

  12. Study of Reversible Logic Synthesis with Application in SOC: A Review

    Science.gov (United States)

    Sharma, Chinmay; Pahuja, Hitesh; Dadhwal, Mandeep; Singh, Balwinder

    2017-08-01

    The prime concern in today’s SOC designs is the power dissipation which increases with technology scaling. The reversible logic possesses very high potential in reducing power dissipation in these designs. It finds its application in latest research fields such as DNA computing, quantum computing, ultra-low power CMOS design and nanotechnology. The reversible circuits can be easily designed using the conventional CMOS technology at a cost of a garbage output which maintains the reversibility. The purpose of this paper is to provide an overview of the developments that have occurred till date in this concept and how the new reversible logic gates are used to design the logic functions.

  13. Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Daqing [Department of Respiration, Xi’an Children’s Hospital, Xi’an 710003 (China); Wang, Jing [Department of Neonatology, Xi’an Children’s Hospital, Xi’an 710003 (China); Yang, Niandi [Outpatient Department, School of Aerospace Engineering, Air Force Engineering University, Xi’an 710038 (China); Ma, Haixin, E-mail: drhaixinma@163.com [Department of Quality Control, Xi’an Children’s Hospital, Xi’an 710003 (China)

    2016-08-12

    Matrine has been demonstrated to attenuate allergic airway inflammation. Elevated suppressor of cytokine signaling 3 (SOCS3) was correlated with the severity of asthma. The aim of this study was to investigate the effect of matrine on SOCS3 expression in airway inflammation. In this study, we found that matrine significantly inhibited OVA-induced AHR, inflammatory cell infiltration, goblet cell differentiation, and mucous production in a dose-dependent manner in mice. Matrine also abrogated the level of interleukin (IL)-4 and IL-13, but enhanced interferon (IFN)-γ expression, both in BALF and in lung homogenates. Furthermore, matrine impeded TNF-α-induced the expression of IL-6 and adhesion molecules in airway epithelial cells (BEAS-2B and MLE-12). Additionally, we found that matrine inhibited SOCS3 expression, both in asthmatic mice and TNF-α-stimulated epithelial cells via suppression of the NF-κB signaling pathway by using pcDNA3.1-SOCS3 plasmid, SOCS3 siRNA, or nuclear factor kappa-B (NF-κB) inhibitor PDTC. Conclusions: Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice. - Highlights: • Matrine attenuates asthmatic symptoms and regulates Th1/Th2 balance in vivo. • Matrine suppresses inflammation responses in vitro. • Matrine decreases SOCS3 expression both in vivo and in vitro. • Matrine inhibits SOCS3 expression by suppressing NF-κB signaling.

  14. Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain

    Directory of Open Access Journals (Sweden)

    Mignot Emmanuel

    2007-05-01

    Full Text Available Abstract Background Narcolepsy causes dramatic behavioral alterations in both humans and dogs, with excessive sleepiness and cataplexy triggered by emotional stimuli. Deficiencies in the hypocretin system are well established as the origin of the condition; both from studies in humans who lack the hypocretin ligand (HCRT and in dogs with a mutation in hypocretin receptor 2 (HCRTR2. However, little is known about molecular alterations downstream of the hypocretin signals. Results By using microarray technology we have screened the expression of 29760 genes in the brains of Doberman dogs with a heritable form of narcolepsy (homozygous for the canarc-1 [HCRTR-2-2] mutation, and their unaffected heterozygous siblings. We identified two neuropeptide precursor molecules, Tachykinin precursor 1 (TAC1 and Proenkephalin (PENK, that together with Suppressor of cytokine signaling 2 (SOCS2, showed reduced expression in narcoleptic brains. The difference was particularly pronounced in the amygdala, where mRNA levels of PENK were 6.2 fold lower in narcoleptic dogs than in heterozygous siblings, and TAC1 and SOCS2 showed 4.4 fold and 2.8 fold decrease in expression, respectively. The results obtained from microarray experiments were confirmed by real-time RT-PCR. Interestingly, it was previously shown that a single dose of amphetamine-like stimulants able to increase wakefulness in the dogs, also produce an increase in the expression of both TAC1 and PENK in mice. Conclusion These results suggest that TAC1, PENK and SOCS2 might be intimately connected with the excessive daytime sleepiness not only in dogs, but also in other species, possibly including humans.

  15. Parametric Dense Stereovision Implementation on a System-on Chip (SoC

    Directory of Open Access Journals (Sweden)

    Pablo Montejo

    2012-02-01

    Full Text Available This paper proposes a novel hardware implementation of a dense recovery of stereovision 3D measurements. Traditionally 3D stereo systems have imposed the maximum number of stereo correspondences, introducing a large restriction on artificial vision algorithms. The proposed system-on-chip (SoC provides great performance and efficiency, with a scalable architecture available for many different situations, addressing real time processing of stereo image flow. Using double buffering techniques properly combined with pipelined processing, the use of reconfigurable hardware achieves a parametrisable SoC which gives the designer the opportunity to decide its right dimension and features. The proposed architecture does not need any external memory because the processing is done as image flow arrives. Our SoC provides 3D data directly without the storage of whole stereo images. Our goal is to obtain high processing speed while maintaining the accuracy of 3D data using minimum resources. Configurable parameters may be controlled by later/parallel stages of the vision algorithm executed on an embedded processor. Considering hardware FPGA clock of 100 MHz, image flows up to 50 frames per second (fps of dense stereo maps of more than 30,000 depth points could be obtained considering 2 Mpix images, with a minimum initial latency. The implementation of computer vision algorithms on reconfigurable hardware, explicitly low level processing, opens up the prospect of its use in autonomous systems, and they can act as a coprocessor to reconstruct 3D images with high density information in real time.

  16. IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: Regulation by SOCS3

    International Nuclear Information System (INIS)

    Sun Rui; Jaruga, Barbara; Kulkarni, Shailin; Sun Haoyu; Gao Bin

    2005-01-01

    The precise role of IL-6 in liver regeneration and hepatocyte proliferation is controversial and the role of SOCS3 in liver regeneration remains unknown. Here we show that in vitro treatment with IL-6 inhibited primary mouse hepatocyte proliferation. IL-6 induced p21 cip1 protein expression in primary mouse hepatocytes. Disruption of the p21 cip1 gene abolished the inhibitory effect of IL-6 on cell proliferation. Co-culture with nonparenchymal liver cells diminished IL-6 inhibition of hepatocyte proliferation, which was likely due to IL-6 stimulation of nonparenchymal cells to produce HGF. Finally, IL-6 induced higher levels of p21 cip1 protein expression and a slightly stronger inhibition of cell proliferation in SOCS3 +/- mouse hepatocytes compared to wild-type hepatocytes, while liver regeneration was enhanced and prolonged in SOCS3 +/- mice. Our findings suggest that IL-6 directly inhibits hepatocyte proliferation via a p21 cip1 -dependent mechanism and indirectly enhances hepatocyte proliferation via stimulating nonparenchymal cells to produce HGF. SOCS3 negatively regulates liver regeneration

  17. Approche complète de développement des IPs pour les SoCs A ...

    African Journals Online (AJOL)

    CoFluent and Quartus II tools have helped us to get the different models. ... Key words : IPs – SoC - Design and Reuse – UML – System C ... nouvelles techniques de conception doivent- .... obtenir un prototype fabriqué et testé. ..... Information Technology and Control, ... A new logic circuit design methodology with UMLl.

  18. Prediction of SOC content by Vis-NIR spectroscopy at European scale using a modified local PLS algorithm

    Science.gov (United States)

    Nocita, M.; Stevens, A.; Toth, G.; van Wesemael, B.; Montanarella, L.

    2012-12-01

    In the context of global environmental change, the estimation of carbon fluxes between soils and the atmosphere has been the object of a growing number of studies. This has been motivated notably by the possibility to sequester CO2 into soils by increasing the soil organic carbon (SOC) stocks and by the role of SOC in maintaining soil quality. Spatial variability of SOC masks its slow accumulation or depletion, and the sampling density required to detect a change in SOC content is often very high and thus very expensive and labour intensive. Visible near infrared diffuse reflectance spectroscopy (Vis-NIR DRS) has been shown to be a fast, cheap and efficient tool for the prediction of SOC at fine scales. However, when applied to regional or country scales, Vis-NIR DRS did not provide sufficient accuracy as an alternative to standard laboratory soil analysis for SOC monitoring. Under the framework of Land Use/Cover Area Frame Statistical Survey (LUCAS) project of the European Commission's Joint Research Centre (JRC), about 20,000 samples were collected all over European Union. Soil samples were analyzed for several physical and chemical parameters, and scanned with a Vis-NIR spectrometer in the same laboratory. The scope of our research was to predict SOC content at European scale using LUCAS spectral library. We implemented a modified local partial least square regression (l-PLS) including, in addition to spectral distance, other potentially useful covariates (geography, texture, etc.) to select for each unknown sample a group of predicting neighbours. The dataset was split in mineral soils under cropland, mineral soils under grassland, mineral soils under woodland, and organic soils due to the extremely diverse spectral response of the four classes. Four every class training (70%) and test (30%) sets were created to calibrate and validate the SOC prediction models. The results showed very good prediction ability for mineral soils under cropland and mineral soils

  19. Outreach activities on light science and technology at TecnOpto-UMH during the International Year of Light

    Science.gov (United States)

    Sánchez-López, María. del Mar; García-Martínez, Pascuala; Espinosa, Rocío.; Carnicer, Jesús; Arias, Julia; Moreno, Ignacio

    2016-09-01

    TecnOpto is a group of researchers and teachers with interests in Optics and Photonics, located at the University Miguel Hernández (UMH) of Elche (Spain). Here we report on our outreach activities carried out during the International Year of Light - 2015. They include experiments and demonstrations at elementary and secondary schools, seminars and exhibitions at the university, and the activity named the "Classroom for the Experience", targeted to elder people. We also report on our participation in the science fair in Elche and in the launching of "the Room of Light", a complete new section of the MUDIC science museum devoted to light and optics. MUDIC is located in the UMH campus of Orihuela, and receives visitors from all over the region, mainly young students from elementary and secondary schools. Finally, we report on the exhibition "Women in Light Science and Light Technologies" which was organized by members of our group in collaboration with RSEF - the Spanish Royal Physical Society and SEDOPTICA - the Spanish Optical Society and sponsored by SPIE. This exhibition consisting of twelve posters on relevant women scientists was inaugurated in the XI Spanish Meeting on Optics and has travelled around many universities and cultural centers in Spain. A summary of the contents, participation and developing of all these activities is presented.

  20. An acceleration system for Laplacian image fusion based on SoC

    Science.gov (United States)

    Gao, Liwen; Zhao, Hongtu; Qu, Xiujie; Wei, Tianbo; Du, Peng

    2018-04-01

    Based on the analysis of Laplacian image fusion algorithm, this paper proposes a partial pipelining and modular processing architecture, and a SoC based acceleration system is implemented accordingly. Full pipelining method is used for the design of each module, and modules in series form the partial pipelining with unified data formation, which is easy for management and reuse. Integrated with ARM processor, DMA and embedded bare-mental program, this system achieves 4 layers of Laplacian pyramid on the Zynq-7000 board. Experiments show that, with small resources consumption, a couple of 256×256 images can be fused within 1ms, maintaining a fine fusion effect at the same time.

  1. DMA Controller for LEON3 SoC:s Using AMBA

    OpenAIRE

    Nilsson, Emelie

    2013-01-01

    A DMA Controller can offload a processor tremendously. A memory copy operation can be initiated by the processor and while the processor executes others tasks the memory copy can be fulfilled by the DMA Controller. An implementation of a DMA Controller for use in LEON3 SoC:s has been made during this master thesis. Problems that occurred while designing a controller of this type concerned AMBA buses, data transfers, alignment and interrupt handling. The DMA Controller supports AMBA and is att...

  2. Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C.

    Science.gov (United States)

    Wójcik, Kamila; Jabłonowska, Elżbieta; Omulecka, Aleksandra; Piekarska, Anna

    2014-08-14

    To analyze adipokine concentrations, insulin resistance and hepatic expression of suppressor of cytokine signaling 3 (SOCS-3) in patients with chronic hepatitis C genotype 1 with normal body weight, glucose and lipid profile. The study group consisted of 31 patients with chronic hepatitis C and 9 healthy subjects. Total levels of adiponectin, leptin, resistin, visfatin, omentin, osteopontin and insulin were measured using an ELISA kit. The hepatic expression of SOCS-3 was determined by the use of the reverse transcription polymerase chain reaction method. Homeostasis model assessment for insulin resistance (HOMA-IR) values were significantly higher in hepatitis C virus (HCV) infected patients without metabolic disorders compared to healthy controls (2.24 vs 0.59, P = 0.0003). Hepatic steatosis was observed in 32.2% of patients with HCV infection and was found in patients with increased HOMA-IR index (2.81 vs 1.99, P = 0.05) and reduced adiponectin level (5.96 vs 8.37, P = 0.04). Inflammatory activity (G ≥ 2) was related to increased osteopontin concentration (34.04 vs 23.35, P = 0.03). Advanced liver fibrosis (S ≥ 2) was associated with increased levels of omentin and osteopontin (436.94 vs 360.09, P = 0.03 and 32.84 vs 20.29, P = 0.03) and reduced resistin concentration (1.40 vs 1.74, P = 0.047). No correlations were reported between adipokine profile, HOMA-IR values and hepatic expression of the SOCS-3 gene. We speculated that no relationship between adipokines and HOMA-IR values may indicate that HCV can induce insulin resistance itself. Some adipokines appear to be biochemical markers of steatosis, inflammation and fibrosis in patients with chronic HCV infection. © 2014 Baishideng Publishing Group Inc. All rights reserved.

  3. Energy efficient HPC on embedded SoCs : optimization techniques for mali GPU

    OpenAIRE

    Grasso, Ivan; Radojkovic, Petar; Rajovic, Nikola; Gelado Fernandez, Isaac; Ramírez Bellido, Alejandro

    2014-01-01

    A lot of effort from academia and industry has been invested in exploring the suitability of low-power embedded technologies for HPC. Although state-of-the-art embedded systems-on-chip (SoCs) inherently contain GPUs that could be used for HPC, their performance and energy capabilities have never been evaluated. Two reasons contribute to the above. Primarily, embedded GPUs until now, have not supported 64-bit floating point arithmetic - a requirement for HPC. Secondly, embedded GPUs did not pr...

  4. Proceedings of the International Wire and Cable Symposium (38th) Held in Atlanta, Georgia on November 14-16, 1989

    Science.gov (United States)

    1989-11-01

    J. Skutnik, W. B. Beck and M. !1. ladge, SPIE and very good and predictable Etigue recistance Vol. 787, 8 (1987). have outperformed hermetic-coated...is highly c onducive to hydrogen bonds chemically to the dopants in the corrosion, both galvanicand bacterial glass, leading to a large and...or the of the hydrogen found in these cables has not yet level of hydrogen encountered along the submarine been positively identified. Both bacterial

  5. Proposal for the award of an industrial services contract for civil engineering superstructure and internal construction building work

    CERN Document Server

    2001-01-01

    This document concerns the award of an Industrial Services contract for civil engineering superstructure and internal construction building work. Following a market survey carried out among 112 firms in fifteen Member States, a call for tenders (IT-2546/ST/Rev.) was sent on 12 April 2001 to eleven consortia, four consisting of four firms, three consisting of three firms and four consisting of two firms, in seven Member States. By the closing date, CERN had received tenders from eight consortia in six Member States. The Finance Committee is invited to agree to the negotiation of a contract with the consortium SPIE CITRA SUD-EST(FR)-ANTIRUST TECHNOLOGY (GR), the lowest bidder, for an initial period of three years from 1 January 2002 for an amount not exceeding 15 375 000 Swiss francs, not subject to revision. The contract will include options for two one-year extensions beyond the initial three-year period. The consortium has indicated the following distribution by country of the contract value covered by this ...

  6. Pengaruh Variasi Jumlah Tembakan Nanosecond Pulsed Electric Fields (Nspefs Terhadap Ekspresi Gen Socs3 pada Sel Kanker Serviks Hela S3

    Directory of Open Access Journals (Sweden)

    Martina Kurnia Rohmah

    2017-12-01

    Abstract Nanosecond Pulsed Electric Fields (NsPEFs is bioelectric that was developed by electroporation technology. NsPEFs use high intensity in short time exposure (1 – 300 nanosecond. NsPEFs have biological effect and was developed in cancer therapy. In cervical cancer, viral protein of HPV depresses some tumor suppressors like Socs3 gene. This research aims to investigate the effect of short variation in Socs3 gene expression. HeLa S3 cells were cultured in α-MEM with FBS 10%. NsPEFs as much as 20 kV/cm and 80 nano seconds was exposure over HeLa S3 cell in 4 mm cuvette. Wave of NsPEFs was detected by high voltage probe in oscilloscope. NsPEFs was exposure at 0 (control, 5, 10, 20, 30, 40, 50, and 60 shots. Socs3 gene expression was analyzed using real time PCR and RT-PCR. Quantitative data was analyzed by Kolmogorov-Smirnov, Anova, and HSD Tuker (p<0.05. This research show that NsPEFs is significantly increase Socs3 gene expression (p=0.000. The optimal shot 20 and 30 shots increase Socs3 gene expression subsequently = 2.779 and = 3.105 times. This expression decrease in higher than 30 shots of NsPEFs exposure.   Keywords: NsPEFs, shot, expression, Socs3

  7. Considerations Regarding the International Taxation

    Directory of Open Access Journals (Sweden)

    Tatiana Mosteanu

    2007-03-01

    Full Text Available Taxation, an essential element of an efficient public finance system, is the best way for collecting income to achive the public expenditures programs and, in the same time, a way to redistribute the income, in order to get rid of poverty and to ensure social equity. Studies on the topic of international taxation, in its traditional meaning, were addressed to the problems regarding the international taxation effects on trade and investments, unequitable and discriminatory taxation, also the means of preventing such cases, international fiscal evasion, all these aspects being comprised into the area of fiscal competition. The present concept of international taxation, meant to cross states borders, in order to redistribute the income or to achive other objectives with international implications, such as fight against poverty, maintaining world peace or environment protection, is a quite recent one.

  8. Monolithic distributed power management for systems-on-chip (SoC); Gestion monolithique distribuee de puissance pour les systemes sur puce (SOC)

    Energy Technology Data Exchange (ETDEWEB)

    Abedinpour, S. [Motorola, Semiconductor Products Sector, Tempe (United States); Bakkaloglu, B. [Texas Instruments, Broadband Communications Group, Dallas, Texas (United States); Kiaei, S. [Arizona State Univ., Connection one Research Center, Tempe (United States)

    2004-08-01

    With increasing drive towards higher level of integration, lower cost, and longer battery life in wireless applications, there is a need for efficient monolithic DC-DC power converters. This tutorial paper summarizes the topology tradeoffs that are involved in the implementation of monolithic distributed power management in the future generations of SoCs for portable wireless applications. These circuits have a broad range of requirements including high power density, high energy efficiency, low noise, small size, and low cost. The advantages and disadvantages of each of the competing topologies, namely low-dropout linear, switched capacitor, and switched-mode DC-DC converters are examined in light of these requirements. (authors)

  9. The International Bleeding Risk Score

    DEFF Research Database (Denmark)

    Laursen, Stig Borbjerg; Laine, L.; Dalton, H.

    2017-01-01

    The International Bleeding Risk Score: A New Risk Score that can Accurately Predict Mortality in Patients with Upper GI-Bleeding.......The International Bleeding Risk Score: A New Risk Score that can Accurately Predict Mortality in Patients with Upper GI-Bleeding....

  10. The law of international organisations

    CERN Document Server

    White, Nigel D

    2017-01-01

    This book provides a concise account of the principles and norms of international law applicable to the main-type of international organisation - the inter-governmental organisation (IGO). That law consists of principles and rules found in the founding documents of IGOs along with applicable principles and rules of international law. The book also identifies and analyses the law produced by IGOs, applied by them and, occasionally, enforced by them. There is a concentration upon the United Nations, as the paradigmatic IGO, not only upon the UN organisation headquartered in New York, but on other IGOs in the UN system (the specialised agencies such as the World Health Organisation).

  11. Observation of self-organized criticality (SOC) behavior during edge biasing experiment on TEXTOR

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Y.H.; Jachmich, S.; Weynants, R.R. [Ecole Royale Militaire/Koninklijke Militaire School, Laboratory for Plasma Physics, Euratom-Belgian State Association, Brussels, Belgium, Partner in the Trilateral Euregio Cluster (Belgium)

    2004-07-01

    The self-organized criticality (SOC) behavior of the edge plasma transport has been investigated using the fluctuation data measured in the plasma edge and the scrape-off layer of TEXTOR tokamak before and during the edge electrode biasing experiments. In the 'non-shear' discharge phase before biasing, both the potential and density fluctuations clearly exhibit some of the characteristics associated with SOC: (1) existence of f{sup -1} power-law dependence in the frequency spectrum, (2) slowly decaying long tails in the autocorrelation function, (3) values of Hurst parameters larger than 0.5 at all the detected radial locations, (4) non-Gaussian probability density function of fluctuations and (5) radial propagation of avalanche-like events in the edge plasma area. During the biasing phase, with the generation of an edge radial electric field E{sub r} and hence a sheared E{sub r} x B flow, the local turbulence is found to be well de-correlated by the E{sub r} x B velocity shear, consistent with theoretical predictions. Nevertheless, it is concomitantly found that the Hurst parameters are substantially enhanced in the negative flow shear region and in the scrape-off layer as well, which is contrary to theoretical expectation. Implication of these observations to our understanding of plasma transport mechanisms is discussed. (authors)

  12. The internal control of tax

    OpenAIRE

    E. B. Shuvalova; L. A. Butenko; Ju. A. Rudenko

    2016-01-01

    The aim of the research is to study the theoretical and practical issues of internal fiscal control. Internal tax control system requires the development of methodological tools, its scientific basis and practical recommendations for the application. This difficult task is now solved only in organizations, which are the largest taxpayers. For small and medium-sized businesses in the organization of internal fiscal control may improve the quality of the accounting organization of the company. ...

  13. Detecting small-scale spatial heterogeneity and temporal dynamics of soil organic carbon (SOC) stocks: a comparison between automatic chamber-derived C budgets and repeated soil inventories

    Science.gov (United States)

    Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Juana; Albiac Borraz, Elisa; Schmidt, Marten; Huth, Vytas; Rogasik, Helmut; Rieckh, Helene; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

    2017-03-01

    Carbon (C) sequestration in soils plays a key role in the global C cycle. It is therefore crucial to adequately monitor dynamics in soil organic carbon (ΔSOC) stocks when aiming to reveal underlying processes and potential drivers. However, small-scale spatial (10-30 m) and temporal changes in SOC stocks, particularly pronounced in arable lands, are hard to assess. The main reasons for this are limitations of the well-established methods. On the one hand, repeated soil inventories, often used in long-term field trials, reveal spatial patterns and trends in ΔSOC but require a longer observation period and a sufficient number of repetitions. On the other hand, eddy covariance measurements of C fluxes towards a complete C budget of the soil-plant-atmosphere system may help to obtain temporal ΔSOC patterns but lack small-scale spatial resolution. To overcome these limitations, this study presents a reliable method to detect both short-term temporal dynamics as well as small-scale spatial differences of ΔSOC using measurements of the net ecosystem carbon balance (NECB) as a proxy. To estimate the NECB, a combination of automatic chamber (AC) measurements of CO2 exchange and empirically modeled aboveground biomass development (NPPshoot) were used. To verify our method, results were compared with ΔSOC observed by soil resampling. Soil resampling and AC measurements were performed from 2010 to 2014 at a colluvial depression located in the hummocky ground moraine landscape of northeastern Germany. The measurement site is characterized by a variable groundwater level (GWL) and pronounced small-scale spatial heterogeneity regarding SOC and nitrogen (Nt) stocks. Tendencies and magnitude of ΔSOC values derived by AC measurements and repeated soil inventories corresponded well. The period of maximum plant growth was identified as being most important for the development of spatial differences in annual ΔSOC. Hence, we were able to confirm that AC-based C budgets are able

  14. The international thermonuclear reactor project

    International Nuclear Information System (INIS)

    James, T.R.

    1993-01-01

    The International Thermonuclear Experimental Reactor Project is a 6-year collaborative effort involving the U.S., Europe, Japan, and the Russian Federation to produce a detailed engineering design for the next-step fusion device

  15. THE EMERGING INTERNATIONAL CONSTITUTIONAL ORDER ...

    African Journals Online (AJOL)

    Dr Tanya du Plessis

    CFI) affirmed ... primarily include the value system of the international legal order, meaning norms of ... the existence of such a traditional constitutional demos. Europe's ..... between the African Development Bank (BAD) and one of its employees,.

  16. An ESL Approach for Energy Consumption Analysis of Cache Memories in SoC Platforms

    Directory of Open Access Journals (Sweden)

    Abel G. Silva-Filho

    2011-01-01

    Full Text Available The design of complex circuits as SoCs presents two great challenges to designers. One is the speeding up of system functionality modeling and the second is the implementation of the system in an architecture that meets performance and power consumption requirements. Thus, developing new high-level specification mechanisms for the reduction of the design effort with automatic architecture exploration is a necessity. This paper proposes an Electronic-System-Level (ESL approach for system modeling and cache energy consumption analysis of SoCs called PCacheEnergyAnalyzer. It uses as entry a high-level UML-2.0 profile model of the system and it generates a simulation model of a multicore platform that can be analyzed for cache tuning. PCacheEnergyAnalyzer performs static/dynamic energy consumption analysis of caches on platforms that may have different processors. Architecture exploration is achieved by letting designers choose different processors for platform generation and different mechanisms for cache optimization. PCacheEnergyAnalyzer has been validated with several applications of Mibench, Mediabench, and PowerStone benchmarks, and results show that it provides analysis with reduced simulation effort.

  17. The temporary international collective chronicle

    International Nuclear Information System (INIS)

    Kravchenko, Yu.Ya.

    2007-01-01

    The temporary international collective brief history is presented from the time of its establishment in 1972 (and even earlier) till the termination of its activity in 1990 (and even later). Works in the temporary international collective framework demonstrate an example of successful cooperation of specialists from different countries in the field of calculation-theoretical and experimental research on the WWER reactor physics. The results of experimental and calculation studies were reported to the topical meetings, workshops, conferences, and symposia as well as were published in the temporary international collective reports and proceedings. The answers to the questions about the temporary international collective activity-What? Where? When?-are presented in this chronicle (Authors)

  18. The Newsworthiness of International Terrorism.

    Science.gov (United States)

    Weimann, Gabriel; Brosius, Hans-Bernd

    1991-01-01

    Investigates the newsworthiness of international terrorism. Relates the concept of deviance as a predictor of newsworthiness to the specific attributes of terrorist events and their impact on media selection (coverage or no coverage) and prominence of coverage. (SR)

  19. The Professionalization of Internal Auditing

    OpenAIRE

    Tomasz Gacoń

    2013-01-01

    Purpose: This paper attempts to examine the meaning of professionalization, the conditions required for professionalization and whether internal auditing can be recognized as a profession. The paper makes use of study results in the fi eld of internal auditing conducted in Europe and the USA, as well as Andrew Abbott’s theory on the system of professions. Professions have common characteristics which differentiate them from other occupations. These characteristics were used to determine the c...

  20. The ICC, International Criminal Justice and International Politics ...

    African Journals Online (AJOL)

    The International Criminal Court (ICC) came into being as a result of a desire by the international community to establish a permanent body to deliver criminal justice instead of the formula of ad hoc tribunals that had become the norm. The coming into force of the Rome Statute in 2002 was greeted with euphoria as it ...

  1. Shame and the Internalized Other

    OpenAIRE

    Montes Sánchez, Alba

    2016-01-01

    In Shame and Necessity, Bernard Williams engages in a forceful vindication of the ethical significance of shame. In his view, shame is an extremely productive moral emotion because of the distinctive connection that it establishes between self, others and world, through a self-evaluation that is mediated by an internalized other. In this paper, I examine Williams’ conception of the internalized other and contrast it with other ways of conceiving the role of others in shame. I argue that, alth...

  2. IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma.

    Science.gov (United States)

    Peng, Hsuan-Yu; Jiang, Shih-Sheng; Hsiao, Jenn-Ren; Hsiao, Michael; Hsu, Yuan-Ming; Wu, Guan-Hsun; Chang, Wei-Min; Chang, Jang-Yang; Jin, Shiow-Lian Catherine; Shiah, Shine-Gwo

    2016-06-01

    Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Dysregulation of SOCS protein expression in cancers can be one of the mechanisms that maintain STAT activation, but this mechanism is still poorly understood in oral squamous cell carcinoma (OSCC). Here, we report that SOCS2 protein is significantly downregulated in OSCC patients and its levels are inversely correlated with miR-424-5p expression. We identified the SOCS2 protein, which modulates STAT5 activity, as a direct target of miR-424-5p. The miR-424-5p-induced STAT5 phosphorylation, matrix metalloproteinases (MMPs) expression, and cell migration and invasion were blocked by SOCS2 restoration, suggesting that miR-424-5p exhibits its oncogenic activity through negatively regulating SOCS2 levels. Furthermore, miR-424-5p expression could be induced by the cytokine IL-8 primarily through enhancing STAT5 transcriptional activity rather than NF-κB signaling. Antagomir-mediated inactivation of miR-424-5p prevented the IL-8-induced cell migration and invasion, indicating that miR-424-5p is required for IL-8-induced cellular invasiveness. Taken together, these data indicate that STAT5-dependent expression of miR-424-5p plays an important role in mediating IL-8/STAT5/SOCS2 feedback loop, and scavenging miR-424-5p function using antagomir may have therapeutic potential for the treatment of OSCC. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  3. International Mindedness in Practice: The Evidence from International Baccalaureate Schools

    Science.gov (United States)

    Hacking, Elisabeth Barratt; Blackmore, Chloe; Bullock, Kate; Bunnell, Tristan; Donnelly, Michael; Martin, Susan

    2018-01-01

    International Mindedness is an overarching construct related to multilingualism, intercultural understanding and global engagement (Hill, 2012). The concept is central to the International Baccalaureate (IB) and sits at the heart of its education policies and programmes. The aim of this research study was to examine systematically how schools…

  4. The ICC, International Criminal Justice and International Politics

    African Journals Online (AJOL)

    short, does it have a future, and how shall it remain relevant in the future? This article is a think piece ... Introduction. The International Criminal ... in its operations by international politics, are the ICC's weaknesses a function of its very nature or ...

  5. The International Lunar Decade Declaration

    Science.gov (United States)

    Beldavs, V.; Foing, B.; Bland, D.; Crisafulli, J.

    2015-10-01

    The International Lunar Decade Declaration was discussed at the conference held November 9-13, 2014 in Hawaii "The Next Giant Leap: Leveraging Lunar Assets for Sustainable Pathways to Space" - http://2014giantleap.aerospacehawaii.info/ and accepted by a core group that forms the International Lunar Decade Working Group (ILDWG) that is seeking to make the proposed global event and decade long process a reality. The Declaration will be updated from time to time by members of the ILDWreflecting new knowledge and fresh perspectives that bear on building a global consortium with a mission to progress from lunar exploration to the transformation of the Moon into a wealth gene rating platform for the expansion of humankind into the solar system. When key organizations have endorsed the idea and joined the effort the text of the Declaration will be considered final. An earlier International Lunar Decade proposal was issued at the 8th ICEUM Conference in 2006 in Beijing together with 13 specific initiatives for lunar exploration[1,2,3]. These initiatives have been largely implemented with coordination among the different space agencies involved provided by the International Lunar Exploration Working Group[2,3]. The Second International Lunar Decade from 2015 reflects current trends towards increasing involvement of commercial firms in space, particularly seeking opportunities beyond low Earth orbit. The central vision of the International Lunar Decade is to build the foundations for a sustainable space economy through international collaboration concurrently addressing Lunar exploration and building a shared knowledge base;Policy development that enables collabo rative research and development leading to lunar mining and industrial and commercial development;Infrastructure on the Moon and in cislunar space (communications, transport, energy systems, way-stations, other) that reduces costs, lowers risks and speeds up the time to profitable operations;Enabling technologies

  6. International Education: The International Baccalaureate, Montessori and Global Citizenship

    Science.gov (United States)

    Brunold-Conesa, Cynthia

    2010-01-01

    The International Baccalaureate (IB) programs and Montessori education both claim to promote values associated with global citizenship in order to help prepare students for new challenges presented by an increasingly globalized world. While the IB's secondary programs are widespread in international schools, Montessori programs at that level are…

  7. The nuclear controversy international

    International Nuclear Information System (INIS)

    Doederlein, J.M.

    1975-01-01

    The present paper deals with the following questions: How quickly can the developed nations get as much energy as possible from the nuclear power plants they are building. How can we get a maximum output from a maximum number of nuclear plants to reduce the health and the environment damage that we get from fossil fired power plants. How can we reduce the strain on future generations because of the atmospheric pollution and reduce the strain on future generations because we use up all the oil and the gas that we should leave to them for worthier purposes than energy production. (orig.) [de

  8. PREFACE: I International Scientific School Methods of Digital Image Processing in Optics and Photonics

    Science.gov (United States)

    Gurov, I. P.; Kozlov, S. A.

    2014-09-01

    The first international scientific school "Methods of Digital Image Processing in Optics and Photonics" was held with a view to develop cooperation between world-class experts, young scientists, students and post-graduate students, and to exchange information on the current status and directions of research in the field of digital image processing in optics and photonics. The International Scientific School was managed by: Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University) - Saint Petersburg (Russia) Chernyshevsky Saratov State University - Saratov (Russia) National research nuclear University "MEPHI" (NRNU MEPhI) - Moscow (Russia) The school was held with the participation of the local chapters of Optical Society of America (OSA), the Society of Photo-Optical Instrumentation Engineers (SPIE) and IEEE Photonics Society. Further details, including topics, committees and conference photos are available in the PDF

  9. UD-DKF-based Parameters on-line Identification Method and AEKF-Based SOC Estimation Strategy of Lithium-ion Battery

    Directory of Open Access Journals (Sweden)

    Xuanju Dang

    2014-09-01

    Full Text Available State of charge (SOC is a significant parameter for the Battery Management System (BMS. The accurate estimation of the SOC can not only guarantee the SOC remaining within a reasonable scope of work, but also prevent the battery from being over or deeply-charged to extend the lifespan of battery. In this paper, the third-order RC equivalent circuit model is adopted to describe cell characteristics and the dual Kalman filter (DKF is used online to identify model parameters for battery. In order to avoid the impacts of rounding error calculation leading to the estimation error matrix loss of non-negative qualitative which result in the filtering divergence phenomenon, the UD decomposition method is applied for filtering time and state updates simultaneously to enhance the stability of the algorithm, reduce the computational complexity and improve the high recognition accuracy. Based on the obtained model parameters, Adaptive Extended Kalman Filter (AEKF is introduced to online estimate the SOC of battery. The simulation and experimental results demonstrate that the established third-order RC equivalent circuit model is effective, and the SOC estimation has a higher precision.

  10. The epochs of international law

    CERN Document Server

    Grewe, Wilhelm G

    2000-01-01

    A theoretical overview and detailed analysis of the history of international law from the Middle Ages through to the end of the twentieth century (updated from the 1984 German language edition). Wilhelm Grewe's "Epochen der Völkerrechtsgeschichte" is widely regarded as one of the classic twentieth century works of international law. This revised translation by Michael Byers of Oxford University makes this important book available to non-German readers for the first time. "The Epochs of International Law" provides a theoretical overview and detailed analysis of the history of international law from the Middle Ages, to the Age of Discovery and the Thirty Years War, from Napoleon Bonaparte to the Treaty of Versailles and the Age of the Single Superpower, and does so in a way that reflects Grewe's own experience as one of Germany's leading diplomats and professors of international law. A new chapter, written by Wilhelm Grewe and Michael Byers, updates the book to 1998, making the revised translation of interest ...

  11. The International Employment Protection Practices

    Directory of Open Access Journals (Sweden)

    Otenko Pavlo V.

    2017-09-01

    Full Text Available The article discusses the need for corporate protection of staff in accordance with both the European and the International labor law. The author defines the essence of the category of «protection of staff», its constituent elements and the importance of function of this mechanism in terms of corporate security. The main methods used in the international practice to achieve a high degree of protection of staff have been systematized and presented. The main stages of development and tendencies concerning the formation of instruments for protection of staff have been analyzed, and the principal indices to assess the degree of protection of staff have been determined.

  12. International Responsibility and the Systemic Character of International Law

    Directory of Open Access Journals (Sweden)

    Saganek Przemysław

    2017-12-01

    Full Text Available The question whether international law is a system is one of the modern topics discussed by specialists of international law. The text of P. Saganek poses this question with respect to the rules on international responsibility. The two aims are to establish whether the rules on state responsibility are a system themselves and whether they may prima facie support the idea of international law as such a system. The two prima facie answers are positive. Every violation of international law gives rise to state responsibility if it can be attributed to a state and no circumstance precluding wrongfulness is in place. In this sense the rules on state responsibility form a sub-system supporting the thesis on the systemic nature of international law. On a closer analysis one can encounter several doubts as to both answers. Paradoxically those rules are too ideal, too systemic. The author – without denying the necessity of several if not the majority of the identified rules – refers to a tendency of presenting as law some non-binding documents prepared by expert groups. This is a part of a wider process of ‘paper-law’. In this sense expert groups engage in ‘creating the language’ in which the true subjects of international law are expected to speak.

  13. Perception SoC Based on an Ultrasonic Array of Sensors: Efficient DSP Core Implementation and Subsequent Experimental Results

    Directory of Open Access Journals (Sweden)

    A. Haidar

    2005-05-01

    Full Text Available We are concerned with the design, implementation, and validation of a perception SoC based on an ultrasonic array of sensors. The proposed SoC is dedicated to ultrasonic echography applications. A rapid prototyping platform is used to implement and validate the new architecture of the digital signal processing (DSP core. The proposed DSP core efficiently integrates all of the necessary ultrasonic B-mode processing modules. It includes digital beamforming, quadrature demodulation of RF signals, digital filtering, and envelope detection of the received signals. This system handles 128 scan lines and 6400 samples per scan line with a 90° angle of view span. The design uses a minimum size lookup memory to store the initial scan information. Rapid prototyping using an ARM/FPGA combination is used to validate the operation of the described system. This system offers significant advantages of portability and a rapid time to market.

  14. Perception SoC Based on an Ultrasonic Array of Sensors: Efficient DSP Core Implementation and Subsequent Experimental Results

    Science.gov (United States)

    Kassem, A.; Sawan, M.; Boukadoum, M.; Haidar, A.

    2005-12-01

    We are concerned with the design, implementation, and validation of a perception SoC based on an ultrasonic array of sensors. The proposed SoC is dedicated to ultrasonic echography applications. A rapid prototyping platform is used to implement and validate the new architecture of the digital signal processing (DSP) core. The proposed DSP core efficiently integrates all of the necessary ultrasonic B-mode processing modules. It includes digital beamforming, quadrature demodulation of RF signals, digital filtering, and envelope detection of the received signals. This system handles 128 scan lines and 6400 samples per scan line with a[InlineEquation not available: see fulltext.] angle of view span. The design uses a minimum size lookup memory to store the initial scan information. Rapid prototyping using an ARM/FPGA combination is used to validate the operation of the described system. This system offers significant advantages of portability and a rapid time to market.

  15. The International Biological Programme

    African Journals Online (AJOL)

    1971-11-20

    Nov 20, 1971 ... mined by the beneficial changes which may be brought about in the quality as ... proportion of the human population, thus there is a special urgency to ... a primitive subsistence economy way of life to a completely urbanized ...

  16. The international electronics industry.

    Science.gov (United States)

    LaDou, J; Rohm, T

    1998-01-01

    High-technology microelectronics has a major presence in countries such as China, India, Indonesia, and Malaysia, now the third-largest manufacturer of semiconductor chips. The migration of European, Japanese, and American companies accommodates regional markets. Low wage rates and limited enforcement of environmental regulations in developing countries also serve as incentives for the dramatic global migration of this industry. The manufacture of microelectonics products is accompanied by a high incidence of occupational illnesses, which may reflect the widespread use of toxic materials. Metals, photoactive chemicals, solvents, acids, and toxic gases are used in a wide variety of combinations and workplace settings. The industry also presents problems of radiation exposure and various occupational stressors, including some unresolved ergonomic issues. The fast-paced changes of the technology underlying this industry, as well as the stringent security precautions, have added to the difficulty of instituting proper health and safety measures. Epidemiologic studies reveal an alarming increase in spontaneous abortions among cleanroom manufacturing workers; no definitive study has yet identified its cause. Other health issues, including occupational cancer, are yet to be studied. The microelectronics industry is a good example of an industry that is exported to many areas of the world before health and safety problems are properly addressed and resolved.

  17. Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer

    Directory of Open Access Journals (Sweden)

    Nelson S. Yee

    2011-03-01

    Genetic analysis of pancreatic development has provided new insights into the mechanisms underlying the formation of exocrine pancreatic neoplasia. Zebrafish sweetbread (swd mutants develop hypoplastic acini and dysmorphic ducts in the exocrine pancreas, with impeded progression of cell division cycle and of epithelial growth. Positional cloning and allelic complementation have revealed that the swd mutations affect the transient receptor potential melastatin-subfamily member 7 (trpm7 gene, which encodes a divalent cation-permeable channel with kinase activity. Supplementary Mg2+ partially rescued the exocrine pancreatic defects of the trpm7 mutants by improving cell-cycle progression and growth and repressing the suppressor of cytokine signaling 3a (socs3a gene. The role of Socs3a in Trpm7-mediated signaling is supported by the findings that socs3a mRNA level is elevated in the trpm7 mutants, and antisense inhibition of socs3a expression improved their exocrine pancreatic growth. TRPM7 is generally overexpressed in human pancreatic adenocarcinoma. TRPM7-deficient cells are impaired in proliferation and arrested in the G0-G1 phases of the cell division cycle. Supplementary Mg2+ rescued the proliferative defect of the TRPM7-deficient cells. Results of this study indicate that Trpm7 regulates exocrine pancreatic development via the Mg2+-sensitive Socs3a pathway, and suggest that aberrant TRPM7-mediated signaling contributes to pancreatic carcinogenesis.

  18. The international reprocessing situation

    International Nuclear Information System (INIS)

    Sornein, J.

    1976-01-01

    It is investigated what volume and availability of reprocessing capacity is needed for LWR (and AGR) fuel elements for Western Europe, USA, and Japan during the period from 1980 to 1990. Taking into account the technical, financial, and licensing difficulties, an optimistic and pessimistic assessment is made especially for Western Europe, and from the findings conclusions are drawn for spent fuel element storage and nuclear power plant construction. (HR/LN) [de

  19. International cooperation for the environment

    DEFF Research Database (Denmark)

    Engfeldt, Lars-Göran; Kjellén, Bo; Liefferink, Duncan

    2003-01-01

    global environmental conference, the United Nations Conference on the Human Environment, was convened on 5 June 1972 in Stockholm. This day in June is now yearly celebrated as the World Environment Day. The motto of the Conference “Only One Earth,” was a revolutionary concept for its time, but is today...... go on without concern for the environment. The international agenda for the environment influences the life of everyone: it determines the price for gasoline, where we can build summer houses, and what food we can buy. This chapter will describe how international cooperation for the environment has...

  20. The internal dosimetry code PLEIADES.

    Science.gov (United States)

    Fell, T P; Phipps, A W; Smith, T J

    2007-01-01

    The International Commission on Radiological Protection (ICRP) has published dose coefficients for the ingestion or inhalation of radionuclides in a series of reports covering intakes by workers and members of the public, including children and pregnant or lactating women. The calculation of these coefficients divides naturally into two distinct parts-the biokinetic and dosimetric. This paper describes in detail the methods used to solve the biokinetic problem in the generation of dose coefficients on behalf of the ICRP, as implemented in the Health Protection Agency's internal dosimetry code PLEIADES. A summary of the dosimetric treatment is included.

  1. The internal dosimetry code PLEIADES

    International Nuclear Information System (INIS)

    Fell, T. P.; Phipps, A. W.; Smith, T. J.

    2007-01-01

    The International Commission on Radiological Protection (ICRP) has published dose coefficients for the ingestion or inhalation of radionuclides in a series of reports covering intakes by workers and members of the public, including children and pregnant or lactating women. The calculation of these coefficients divides naturally into two distinct parts - the biokinetic and dosimetric. This paper describes in detail the methods used to solve the biokinetic problem in the generation of dose coefficients on behalf of the ICRP, as implemented in the Health Protection Agency's internal dosimetry code PLEIADES. A summary of the dosimetric treatment is included. (authors)

  2. The International Planetary Data Alliance

    Science.gov (United States)

    Stein, T.; Arviset, C.; Crichton, D. J.

    2017-12-01

    The International Planetary Data Alliance (IPDA) is an association of partners with the aim of improving the quality of planetary science data and services to the end users of space based instrumentation. The specific mission of the IPDA is to facilitate global access to, and exchange of, high quality scientific data products managed across international boundaries. Ensuring proper capture, accessibility and availability of the data is the task of the individual member space agencies. The IPDA was formed in 2006 with the purpose of adopting standards and developing collaborations across agencies to ensure data is captured in common formats. Member agencies include: Armenian Astronomical Society, China National Space Agency (CNSA), European Space Agency (ESA), German Aerospace Center (DLR), Indian Space Research Organization (ISRO), Italian Space Agency (ASI), Japanese Aerospace Exploration Agency (JAXA), National Air and Space Administration (NASA), National Centre for Space Studies (CNES), Space Research Institute (IKI), UAE Space Agency, and UK Space Agency. The IPDA Steering Committee oversees the execution of projects and coordinates international collaboration. The IPDA conducts a number of focused projects to enable interoperability, construction of compatible archives, and the operation of the IPDA as a whole. These projects have helped to establish the IPDA and to move the collaboration forward. A key project that is currently underway is the implementation of the PDS4 data standard. Given the international focus, it has been critical that the PDS and the IPDA collaborate on its development. Also, other projects have been conducted successfully, including developing the IPDA architecture and corresponding requirements, developing shared registries for data and tools across international boundaries, and common templates for supporting agreements for archiving and sharing data for international missions. Several projects demonstrating interoperability across

  3. A project to study SOC evolution after land use change combining chronosequence and gradient methods

    Science.gov (United States)

    Gabarron-Galeote, Miguel A.; van Wesemael, Bas

    2013-04-01

    In the last decades the interest in the global C budget has increased enormously and soils have a great importance in this issue since they contain about twice as much carbon as the atmosphere. Land use change (LUC) can cause a change in land cover and an associated change in carbon stocks in soils, so it has a major impact in the balance between inputs and outputs of soil organic carbon (SOC). Improved understanding of land-use impacts on the world's terrestrial carbon balance is thus a necessary part of the global effort to mitigate climate change. The aim of this project is to predict the effects of land use and land management change on (SOC) stocks, characterizing the soil organic carbon cycle and its relationship to the vegetal cover in croplands abandoned different years ago and under different Mediterranean climatic conditions in South of Spain. The study area is located in the Cordillera Bética Litoral, in South of Spain. In this area, a climatic gradient can be observed from West to East: from >1,500 mm year-1 in the Strait of Gibraltar to <250 mm year-1 in the Cabo de Gata. More specifically, the study is focussed on three different areas from the climatic conditions point of view: Gaucín (1010 mm year-1), Almogía, (576 mm year-1) and Gérgal (240 mm year-1). By means of the analyses of aerial photographs (1956, 1977, 1984, 1998 and 2009) all the experimental plots will be selected. After this procedure, the three study areas will be composed by experimental plots of these classes: a) Lands with natural vegetation since 1956. b) Abandoned lands between 1956 and 1977. c) Abandoned lands between 1977 and 1984. d) Abandoned lands between 1984 and 1998. e) Abandoned lands between 1998 and 2005. f) Cultivated lands since 1956. The main expected outcomes of the research project are the characterization of the temporal evolution of SOC in soils, the compilation of experimental areas under different Mediterranean climatic conditions, and the characterization

  4. Soil organic carbon (SOC) accumulation in rice paddies under long-term agro-ecosystem experiments in southern China - VI. Changes in microbial community structure and respiratory activity

    Science.gov (United States)

    Liu, D.; Liu, X.; Liu, Y.; Li, L.; Pan, G.; Crowley, D.; Tippkötter, R.

    2011-02-01

    Biological stabilization within accumulated soil organic carbon (SOC) has not been well understood, while its role in physical and chemical protection as well as of chemical recalcitrance had been addressed in Chinese rice paddies. In this study, topsoil samples were collected and respiratory activity measured in situ following rice harvest under different fertilization treatments of three long-term experimental sites across southern China in 2009. The SOC contents, microbial biomass carbon (SMBC) and nitrogen (SMBN) were analysed using chemical digestion and microbial community structure assessment via clony dilute plate counting methods. While SOC contents were consistently higher under compound chemical fertilization (Comp-Fert) or combined organic and inorganic fertilization (Comb-Fert) compared to N fertilization only (N-Fert), there was significantly higher fungal-bacterial ratio under Comb-Fert than under N-Fert and Comp-Fert. When subtracting the background effect under no fertilization treatment (Non-Fert), the increase both in SMBC and SMBN under fertilization treatment was found very significantly correlated to the increase in SOC over controls across the sites. Also, the ratio of culturable fungal to bacterial population numbers (F/B ratio) was well correlated with soil organic carbon contents in all samples across the sites studied. SOC accumulation favoured a build-up the microbial community with increasing fungal dominance in the rice paddies under fertilization treatments. While soil respiration rates were high under Comb-Fert as a result of enhanced microbial community build-up, the specific soil respiratory activity based on microbial biomass carbon was found in a significantly negatively correlation with the SOC contents for overall samples. Thus, a fungal-dominated microbial community seemed to slow SOC turnover, thereby favouring SOC accumulation under Comp-Fert or under Comb-Fert in the rice paddies. Therefore, the biological stabilization

  5. The Internal Other

    DEFF Research Database (Denmark)

    Eriksson, Madeleine; Pristed Nielsen, Helene; Paulgaard, Gry

    2015-01-01

    This chapter contains a critical discussion of constructions of center and periphery in a Nordic context, and the discursive and material implications thereof. Specifically, it takes its starting point in representations of northernmost Denmark, Norway and Sweden, and discusses how discursive con...

  6. Calcineurin inhibitor-induced complement system activation via ERK1/2 signalling is inhibited by SOCS-3 in human renal tubule cells.

    Science.gov (United States)

    Loeschenberger, Beatrix; Niess, Lea; Würzner, Reinhard; Schwelberger, Hubert; Eder, Iris E; Puhr, Martin; Guenther, Julia; Troppmair, Jakob; Rudnicki, Michael; Neuwirt, Hannes

    2018-02-01

    One factor that significantly contributes to renal allograft loss is chronic calcineurin inhibitor (CNI) nephrotoxicity (CIN). Among other factors, the complement (C-) system has been proposed to be involved CIN development. Hence, we investigated the impact of CNIs on intracellular signalling and the effects on the C-system in human renal tubule cells. In a qPCR array, CNI treatment upregulated C-factors and downregulated SOCS-3 and the complement inhibitors CD46 and CD55. Additionally, ERK1/-2 was required for these regulations. Following knock-down and overexpression of SOCS-3, we found that SOCS-3 inhibits ERK1/-2 signalling. Finally, we assessed terminal complement complex formation, cell viability and apoptosis. Terminal complement complex formation was induced by CNIs. Cell viability was significantly decreased, whereas apoptosis was increased. Both effects were reversed under complement component-depleted conditions. In vivo, increased ERK1/-2 phosphorylation and SOCS-3 downregulation were observed at the time of transplantation in renal allograft patients who developed a progressive decline of renal function in the follow-up compared to stable patients. The progressive cohort also had lower total C3 levels, suggesting higher complement activity at baseline. In conclusion, our data suggest that SOCS-3 inhibits CNI-induced ERK1/-2 signalling, thereby blunting the negative control of C-system activation. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Combined action of taurine and cations of certain metals on post-irradiation survival of SOC cell culture

    International Nuclear Information System (INIS)

    Yartsev, E.I.; Aldonyasov, V.I.; Yakovlev, V.G.

    1975-01-01

    Effects of combined application of taurine and metals (potassium, magnesium, calcium and zinc) on the cell level have been studied. It has been found that various concentrations of taurine and potassium and zinc salts increase the survival of irradiated SOC cells up to 40% while addition of magnesium and calcium salts does not affect the taurine effectiveness. The highest effectiveness is obtained when potassium and taurine are added in equimolar amounts to the incubation medium

  8. The International Big History Association

    Science.gov (United States)

    Duffy, Michael; Duffy, D'Neil

    2013-01-01

    IBHA, the International Big History Association, was organized in 2010 and "promotes the unified, interdisciplinary study and teaching of history of the Cosmos, Earth, Life, and Humanity." This is the vision that Montessori embraced long before the discoveries of modern science fleshed out the story of the evolving universe. "Big…

  9. 3D Embedded Reconfigurable SoC for Expediting Magnetometric Space Missions

    Science.gov (United States)

    Dekoulis, George

    2016-07-01

    This paper describes the development of a state-of-the-art three-dimensional embedded reconfigurable System-on-Chip (SoC) for accelerating the design of future magnetometric space missions. This involves measurements of planetary magnetic fields or measurements of heliospheric physics events' signatures superimposed on the aggregate measurements of the stronger planetary fields. The functionality of the embedded core is fully customizable, therefore, its operation is independent of the magnetic sensor being used. Standard calibration procedures still apply for setting the magnetometer measurements to the desired initial state and removing any seriatim interference inferred by the adjacent environment. The system acts as a pathfinder for future high-resolution heliospheric space missions.

  10. The International Human Epigenome Consortium

    DEFF Research Database (Denmark)

    Stunnenberg, Hendrik G; Hirst, Martin

    2016-01-01

    The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal at http://www.cell.com/consortium/IHEC) highlight the coordinated ac...

  11. [The sense of coherence among nurses].

    Science.gov (United States)

    Malagón-Aguilera, M Carmen; Fuentes-Pumarola, Concepció; Suñer-Soler, Rosa; Bonmatí-Tomàs, Anna; Fernández-Peña, Roser; Bosch-Farré, Cristina

    2012-01-01

    Through the construct "The sense of coherence" (SOC), the salutogenic model explains why people subjected to stressors are able to maintain good health. The SOC was defined by Antonovsky as a global orientation that expresses the extent to which a person has a highly internalized, permanent - but at the same time dynamic - feeling of confidence; this feeling of confidence is predictable and leads to a high probability that events will turn out well. The present article reviews the literature on the SOC in the nursing profession. The results show that the SOC is a protective factor against stressors in the work environment and in the work-life balance. Low SOC levels are associated with health problems such as burnout or depression, as well as certain personality traits. Copyright © 2012 Elsevier España, S.L. All rights reserved.

  12. International collaborations through the internet

    DEFF Research Database (Denmark)

    Olson, Gary M.; David, Paul A.; Eksteen, Johan

    2007-01-01

    The past decade has seen remarkable advances in the availability of tools to support scientific collaboration at a distance. This is especially good news for international collaborations, where in the past constraints on collocation and travel have made such collaborations a major challenge. The ...

  13. Rapid Development of System-on-Chip (SoC for Network-Enabled Visible Light Communications

    Directory of Open Access Journals (Sweden)

    Trio Adiono

    2018-03-01

    Full Text Available Visible Light Communication (VLC is an emerging optical communication technology with rapid development nowadays. VLC is considered as a compliment and successor of radio-frequency (RF wireless communication. There are various typical implementations of VLC in which one of them is for exchanging data TCP/IP packets, thus the user can browse the internet as in established Wireless fidelity (Wi-Fi technology. Briefly, we can call it by Light fidelity (Li-Fi. This paper described the design and implementation of System-on-Chip (SoC subsystem for Li-Fi application where the implemented SoC consists of hardware (H/W and software (S/W. In the H/W aspect, Physical Layer (PHY is made by using UART communication with Ethernet connection to communicate with Host/Device personal-computer (PC. In the S/W aspect, Xillinux operating system (OS is used. The H/W- as well as S/W-SoC, are realized in FPGA Zybo Zynq-7000 EPP development board. The functional test result shows (without optical channel or Zybo-to-Zybo only that the implemented SoC is working as expected. It is able to exchange TCP/IP packets between two PCs. Moreover, Ethernet connection has bandwidth up to 83.6 Mbps and PHY layer baud rate has bandwidth up to 921600 bps.

  14. THE FUTURE OF INTERNAL AUDIT

    Directory of Open Access Journals (Sweden)

    COSMIN DUMITRU MATIȘ

    2015-03-01

    Full Text Available Over the years, the purpose of internal audit has continued to evolve and expand, managing to successfully transition from its traditional function of monitoring financial statements to the strategic and operational efforts of checking the organization’s compliance at all levels. Regarding the future, it is assumed that the internal audit will play an important advisory role, becoming an important catalyst of business development, focusing organizations on emerging risks. This transformation of the whole internal system, consisting in both control and audit, which seeks to promote a risk-centered organizational culture, is in the process of evolution, but it complexity, the conflicts of interest, the little understanding of most companies when it comes to implementing such a system as well as various issues of credibility, limit the pace of development for now. Our belief, however, is that this slow evolution is favorable for the alternative purpose of building the functions of the new internal control and audit on a more credible and relevant foundation for the organizational management.

  15. System on chip (SoC) microcontrollers (μC) as digitisers for ion beam analysis (IBA) instruments

    Energy Technology Data Exchange (ETDEWEB)

    Whitlow, Harry J., E-mail: harry.j@whitlow.se

    2016-09-15

    Data digitisation of the analogue signals from detectors to digital data is an essential process in ion beam analysis (IBA). The low-cost, easy availability and development environments that have a low learning threshold makes system-on-chip (SoC) microcontrollers (μC) attractive for this task. These μC combine, on one die, analogue and digital inputs and outputs with serial USB interfaces, which opens up simple implementation of tailor-made interfaces for specific IBA measurement systems. We have investigated the design and performance limitations based on development of three different digitisation interfaces for IBA. These were a two-channel nuclear instrumentation module (NIM) ADC event mode interface (EMI) for a high-resolution magnetic RBS spectrometer, a simple headless-multi-channel analyser (MCA) and a combined dual channel headless MCA and EMI. It is shown that SoC μC based interfaces for digitisation of analogue spectroscopy pulses in IBA systems can be implemented for material costs less than 100 €. The performance of the SoC devices for many IBA applications is close to what can be achieved with state-of-the-art instruments. The simple pulse spectroscopy interface circuit and software are included in the auxiliary archive.

  16. Soc stock in different forest-related land-uses in central Stara planina mountain, Bulgaria

    Directory of Open Access Journals (Sweden)

    Zhiyanski Miglena

    2009-01-01

    Full Text Available Forest conversions may lead to an accumulation of carbon in vegetation, but little is known about changes in soil C storage with establishment of plantation forests. Understanding these effects is important to addressing issues relevant to ecosystem function and productivity, and to global balance of carbon. The study investigated the effects of the created coniferous plantations on former beech and pasture sites on the soil organic carbon storage. The major forest-related land-uses in the high mountainous regions of central Stara Planina Mountain were investigated: mountainous pasture, coniferous plantations (planted on previous pasture and beech forests between four and five decades ago and natural beech forests. The experimental data of soil properties, conducted in 2005, 2006 and 2007, were used in determining the variations in organic carbon storage in forest litter and in mineral soil under different land-use patterns. At each site five representative soil profiles were opened and described giving a total 75 soil samples from the soil layers respectively at 0-10, 10-30 and 30-50 cm depth. A total of 55 samples from forest floor layers (Aol, Aof, Aoh and greensward were collected with 25:25 cm plastic frame. The main soil properties were determined in accordance with the standardized methods in the Laboratory of soil science at the Forest Research Institute - BAS. The IPCC Good Practice Guidance for Land Use, Land Use Change and Forestry was used to estimate the soil organic carbon stock in soil and litter. The results obtained showed that the SOC stock was quite similar among forest land-uses. The conversion of natural beech forests to coniferous plantations in studied region is related with slightly expressed decrease in soil carbon storage. The values of SOC stocks in 0-50 cm soil layer in these sites were 8.5 (±2.1 tones/ha for pine and 11.0 (±1.4 tones/ha for spruce, while under the natural beech forest it was 14.8 (±1.0 tones

  17. Algorithm & SoC design for automotive vision systems for smart safe driving system

    CERN Document Server

    Shin, Hyunchul

    2014-01-01

    An emerging trend in the automobile industry is its convergence with information technology (IT). Indeed, it has been estimated that almost 90% of new automobile technologies involve IT in some form. Smart driving technologies that improve safety as well as green fuel technologies are quite representative of the convergence between IT and automobiles. The smart driving technologies include three key elements: sensing of driving environments, detection of objects and potential hazards, and the generation of driving control signals including warning signals. Although radar-based systems are primarily used for sensing the driving environments, the camera has gained importance in advanced driver assistance systems(ADAS). This book covers system-on-a-chip (SoC) designs—including both algorithms and hardware—related with image sensing and object detection by using the camera for smart driving systems. It introduces a variety of algorithms such as lens correction, super resolution, image enhancement, and object ...

  18. Implementation of QoSS (Quality-of-Security Service) for NoC-Based SoC Protection

    Science.gov (United States)

    Sepúlveda, Johanna; Pires, Ricardo; Strum, Marius; Chau, Wang Jiang

    Many of the current electronic systems embedded in a SoC (System-on-Chip) are used to capture, store, manipulate and access critical data, as well as to perform other key functions. In such a scenario, security is considered as an important issue. The Network-on-chip (NoC), as the foreseen communication structure of next-generation SoC devices, can be used to efficiently incorporate security. Our work proposes the implementation of QoSS (Quality of Security Service) to overcome present SoC vulnerabilities. QoSS is a novel concept for data protection that introduces security as a dimension of QoS. In this paper, we present the implementation of two security services (access control and authentication), that may be configured to assume one from several possible levels, the implementation of a technique to avoid denial-of-service (DoS) attacks, evaluate their effectiveness and estimate their impact on NoC performance.

  19. Untrimmed Low-Power Thermal Sensor for SoC in 22 nm Digital Fabrication Technology

    Directory of Open Access Journals (Sweden)

    Ro'ee Eitan

    2014-12-01

    Full Text Available Thermal sensors (TS are essential for achieving optimized performance and reliability in the era of nanoscale microprocessor and system on chip (SoC. Compiling with the low-power and small die area of the mobile computing, the presented TS supports a wide range of sampling frequencies with an optimized power envelope. The TS supports up to 45 K samples/s, low average power consumption, as low as 20 μW, and small core Si area of 0.013 mm2. Advanced circuit techniques are used in order to overcome process variability, ensuring inaccuracy lower than ±2 °C without any calibration. All this makes the presented thermal sensor a cost-effective, low-power solution for 22 nm nanoscale digital process technology.

  20. LOSS OF JAK2 REGULATION VIA VHL-SOCS1 E3 UBIQUITIN HETEROCOMPLEX UNDERLIES CHUVASH POLYCYTHEMIA

    Science.gov (United States)

    Russell, Ryan C.; Sufan, Roxana I.; Zhou, Bing; Heir, Pardeep; Bunda, Severa; Sybingco, Stephanie S.; Greer, Samantha N.; Roche, Olga; Heathcote, Samuel A.; Chow, Vinca W.K.; Boba, Lukasz M.; Richmond, Terri D.; Hickey, Michele M.; Barber, Dwayne L.; Cheresh, David A.; Simon, M. Celeste; Irwin, Meredith S.; Kim, William Y.; Ohh, Michael

    2011-01-01

    SUMMARY Chuvash polycythemia (CP) is a rare congenital form of polycythemia caused by homozygous R200W and H191D mutations in the von Hippel-Lindau (VHL) gene whose gene product is the principal negative regulator of hypoxia-inducible factor. However, the molecular mechanisms underlying some of the hallmark features of CP such as hypersensitivity to erythropoietin are unclear. Here, we show that VHL directly binds suppressor of cytokine signalling 1 (SOCS1) to form a heterodimeric E3 ligase that targets phosphorylated (p)JAK2 for ubiquitin-mediated destruction. In contrast, CP-associated VHL mutants have altered affinity for SOCS1 and fail to engage and degrade pJAK2. Systemic administration of a highly selective JAK2 inhibitor, TG101209, reverses the disease phenotype in vhlR200W/R200W knock-in mice, a model that faithfully recapitulates human CP. These results reveal VHL as a SOCS1-cooperative negative regulator of JAK2 and provide compelling biochemical and preclinical evidence for JAK2- targeted therapy in CP patients. PMID:21685897

  1. Proceedings of the International Conference on Soft Computing for Problem Solving

    CERN Document Server

    Nagar, Atulya; Pant, Millie; Bansal, Jagdish

    2012-01-01

    The present book is based on the research papers presented in the International Conference on Soft Computing for Problem Solving (SocProS 2011), held at Roorkee, India. This book is divided into two volumes and covers a variety of topics, including mathematical modeling, image processing, optimization, swarm intelligence, evolutionary algorithms, fuzzy logic, neural networks, forecasting, data mining etc. Particular emphasis is laid on Soft Computing and its application to diverse fields. The prime objective of the book is to familiarize the reader with the latest scientific developments that are taking place in various fields and the latest sophisticated problem solving tools that are being developed to deal with the complex and intricate problems that are otherwise difficult to solve by the usual and traditional methods. The book is directed to the researchers and scientists engaged in various fields of Science and Technology.

  2. Proceedings of the International Conference on Soft Computing for Problem Solving

    CERN Document Server

    Nagar, Atulya; Pant, Millie; Bansal, Jagdish

    2012-01-01

    The present book is based on the research papers presented in the International Conference on Soft Computing for Problem Solving (SocProS 2011), held at Roorkee, India. This book is divided into two volumes and covers a variety of topics, including mathematical modeling, image processing, optimization, swarm intelligence, evolutionary algorithms, fuzzy logic, neural networks, forecasting, data mining etc. Particular emphasis is laid on Soft Computing and its application to diverse fields. The prime objective of the book is to familiarize the reader with the latest scientific developments that are taking place in various fields and the latest sophisticated problem solving tools that are being developed to deal with the complex and intricate problems that are otherwise difficult to solve by the usual and traditional methods. The book is directed to the researchers and scientists engaged in various fields of Science and Technology.

  3. The Internal Resistance of Supercapacitors

    Science.gov (United States)

    Costa, G. G. G.; Pietronero, R. C.; Catunda, T.

    2012-01-01

    In this paper we study the transient behaviour of RC circuits with supercapacitors, varying R between 1 and 100 [omega]. We demonstrate that supercapacitors behave as ideal capacitors in series with an internal resistance (r [similar to] 8 [omega] for C = 0.2 F, 5.5 V). This result is important to optimize the demonstration of RC circuits using a…

  4. SocRobust (Management tools and a management framework for assessing the potetial long-term S&T options to become embedded in society) Final Report; Project SOE 1981126 of the TSER Programme of the European Commission,

    NARCIS (Netherlands)

    Laredo, Philippe; Rip, Arie; Jolivet, Eric; Shove, Elizabeth; Raman, Sujatha; Moors, E.H.M.; Poti, Bianca; Schaeffer, Gerrit Jan; Penan, Herv; Clara Eugenia, Garcia

    2002-01-01

    This project concerns the management of especially risky and uncertain forms of innovation. More precisely, it concentrates on architectural or radical innovations which by their nature challenge existing technological conventions, regulatory frameworks, and established relations between consumers

  5. International Telecommunication Control: International Law and the Ordering of Satellite and Other Forms of International Broadcasting.

    Science.gov (United States)

    Smith, Delbert D.

    The need for and the available alternatives for international telecommunication controls are examined, and a functional approach to this area of law is offered. Information from a number of areas is collected and examined as it relates to the basic problem. These areas include general principles of international law, the activities of the…

  6. Relationship between the international marketing research and the international marketing information system

    OpenAIRE

    Grubor Aleksandar

    2004-01-01

    Real and complete understanding relationship between the international marketing research and the international marketing information system requires recognizing essentials of the both concept. The international marketing research constitutes a process with coherent phases, whereas the international marketing information system is a part of integrated company's information system. Approach to learning relationship between the international marketing research and the international marketing in...

  7. Universal interface on Zynq"® SoC with CAN, RS-232, Ethernet and AXI GPIO for instrumentation & control

    International Nuclear Information System (INIS)

    Kumar, Abhijeet; Rajpal, Rachana; Pujara, Harshad; Mandaliya, Hitesh; Edappala, Praveenalal

    2016-01-01

    Highlights: • We have designed Universal Interface on Zynq"® SoC with CAN, RS-232, Ethernet and AXI GPIO for Instrumentation & Control. This project is based on Zynq"®-7000 family xc7z020clg484-1 chip. • We explored the full design flow starting from the hardware development in Vivado to software development in SDK using APIs in C language and then interfacing the host application developed in LabVIEW. • We also explored how to make custom IP with AXI bus interface in Vivado. • Useful for those who wants to make custom hardware on Zynq"® SoC. - Abstract: This paper describes an application developed on the latest Zynq"®-7000 All Programmable SoC (AP SoC) [1] devices which integrate the software programmability of an ARM"®-based processor with the hardware programmability of an FPGA, on a single device. In this paper we have implemented application which uses various interfaces like CAN, RS-232, Ethernet and AXI GPIO, so that our host application running on PC in LabVIEW can communicates with any hardware which has at least any one of the available interface. Zynq-7000 All Programmable SoCs (System On Chip) infuse customizable intelligence into today’s embedded systems to suit your unique application requirements. This family of FPGA is meant for high end application because it has huge resources on single chip. It offers you to make your own custom hardware IP, in fact we have made our custom IP called myIP in our design. The beauty of this chip is that it can write drivers for your custom IP which has AXI bus layer attached. After exporting the hardware information to the Software Development Kit (SDK), the tool is able to write drivers for your custom IP. This simplifies your development to a great extent. In a way this application provides the universal interfacing option to user. User can also write the digital data on the GPIO (General Purpose Input Output) through LabVIEW Test application GUI. This project can be used for remote control and

  8. DMPD: Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17070092 Suppressor of cytokine signaling (SOCS) 2, a protein with multiple function...Epub 2006 Oct 27. (.png) (.svg) (.html) (.csml) Show Suppressor of cytokine signaling (SOCS) 2, a protein with multiple function...SOCS) 2, a protein with multiple functions. Authors Rico-Bautista E, Flores-Morales A, Fernandez-Perez L. Pu

  9. DMPD: Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18406369 Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins...svg) (.html) (.csml) Show Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins. ...PubmedID 18406369 Title Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins

  10. Perspectives on the International and Internal Nuclear Security Regime

    International Nuclear Information System (INIS)

    Jang, Sung Soon

    2015-01-01

    The term, 'Nuclear Security' became more familiar to Korean public after the government hosted 2012 Seoul Nuclear Security Summit. Nuclear Security is prevention of, detection of and response to criminal or intentional unauthorized acts involving or directed at nuclear material, other radioactive material, associated facilities, or associated activities. Nuclear Security includes physical protection, security of radioactive sources, nuclear forensics, nuclear smuggling prevention, border monitoring, and cyber security with regard to nuclear and other radiological materials. This abstract will review recent international trends and discuss the nuclear security regime in the Republic of Korea (ROK). The international Nuclear Security Regime has been strengthened. The upcoming Chicago Summit in 2016 and the entry into force of the Amendment of Convention on Physical Protection of Nuclear Materials (CPPNM) will bring major changes in nuclear security. The Republic of Korea hosted the 2012 Seoul Summit and strengthened domestic regime to meet international standards. The ROK has worked hard to contribute to the international security regime and to establish a robust domestic security regime against terrorist threats. Even if the nuclear security regime is robust, Risk-informed Nuclear Security management should be established to meet international standards and to implement effective as well as an efficient nuclear security regime

  11. Perspectives on the International and Internal Nuclear Security Regime

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Sung Soon [Korea Nuclear Non-proliferation and Control, Daejeon (Korea, Republic of)

    2015-10-15

    The term, 'Nuclear Security' became more familiar to Korean public after the government hosted 2012 Seoul Nuclear Security Summit. Nuclear Security is prevention of, detection of and response to criminal or intentional unauthorized acts involving or directed at nuclear material, other radioactive material, associated facilities, or associated activities. Nuclear Security includes physical protection, security of radioactive sources, nuclear forensics, nuclear smuggling prevention, border monitoring, and cyber security with regard to nuclear and other radiological materials. This abstract will review recent international trends and discuss the nuclear security regime in the Republic of Korea (ROK). The international Nuclear Security Regime has been strengthened. The upcoming Chicago Summit in 2016 and the entry into force of the Amendment of Convention on Physical Protection of Nuclear Materials (CPPNM) will bring major changes in nuclear security. The Republic of Korea hosted the 2012 Seoul Summit and strengthened domestic regime to meet international standards. The ROK has worked hard to contribute to the international security regime and to establish a robust domestic security regime against terrorist threats. Even if the nuclear security regime is robust, Risk-informed Nuclear Security management should be established to meet international standards and to implement effective as well as an efficient nuclear security regime.

  12. The international thermonuclear reactor (ITER)

    International Nuclear Information System (INIS)

    Fowler, T.K.; Henning, C.D.

    1987-01-01

    Four governmental groups, representing Europe, Japan, USSR and U.S. met in March 1987 to consider a new international design of a magnetic fusion device for the 1990's. An interim group was appointed. The author gives a brief synopsis of what might be thought of as a draft charter. The starting point is the objective of the ITER device, which is summarized as demonstrating both scientific and technical feasibility of fusion. The paper presents an update on the current thinking and technical aspects for the International Thermonuclear Experimental Reactor (ITER). This covers not only what is happening in the U.S. but also some reports of preliminary thinking of the last technical work that occurred in Vienna

  13. The precautionary principle in international environmental law and international jurisprudence

    Directory of Open Access Journals (Sweden)

    Tubić Bojan

    2014-01-01

    Full Text Available This paper analysis international regulation of the precautionary principle as one of environmental principles. This principle envisages that when there are threats of serious and irreparable harm, as a consequence of certain economic activity, the lack of scientific evidence and full certainty cannot be used as a reason for postponing efficient measures for preventing environmental harm. From economic point of view, the application of precautionary principle is problematic, because it creates larger responsibility for those who create possible risks, comparing to the previous period. The precautionary principle can be found in numerous international treaties in this field, which regulate it in a very similar manner. There is no consensus in doctrine whether this principle has reached the level of international customary law, because it was interpreted differently and it was not accepted by large number of countries in their national legislations. It represents a developing concept which is consisted of changing positions on adequate roles of science, economy, politics and law in the field of environmental protection. This principle has been discussed in several cases before International Court of Justice and International Tribunal for the Law of the Sea.

  14. Shame and the Internalized Other

    DEFF Research Database (Denmark)

    Montes Sanchez, Alba

    2015-01-01

    In Shame and Necessity, Bernard Williams engages in a forceful vindication of the ethical significance of shame. In his view, shame is an extremely productive moral emotion because of the distinctive connection that it establishes between self, others and world, through a self-evaluation that is ......In Shame and Necessity, Bernard Williams engages in a forceful vindication of the ethical significance of shame. In his view, shame is an extremely productive moral emotion because of the distinctive connection that it establishes between self, others and world, through a self......-evaluation that is mediated by an internalized other. In this paper, I examine Williams’ conception of the internalized other and contrast it with other ways of conceiving the role of others in shame. I argue that, although Williams’ views contain many important insights, much is to be gained by conceiving the role of others...

  15. Assessing SOC labile fractions through respiration test, density-size fractionation and thermal analysis - A comparison of methods

    Science.gov (United States)

    Soucemarianadin, Laure; Cécillon, Lauric; Chenu, Claire; Baudin, François; Nicolas, Manuel; Savignac, Florence; Barré, Pierre

    2017-04-01

    Soil organic matter (SOM) is the biggest terrestrial carbon reservoir, storing 3 to 4 times more carbon than the atmosphere. However, despite its major importance for climate regulation SOM dynamics remains insufficiently understood. For instance, there is still no widely accepted method to assess SOM lability. Soil respiration tests and particulate organic matter (POM) obtained by different fractionation schemes have been used for decades and are now considered as classical estimates of very labile and labile soil organic carbon (SOC), respectively. But the pertinence of these methods to characterize SOM turnover can be questioned. Moreover, they are very time-consuming and their reproducibility might be an issue. Alternate ways of determining the labile SOC component are thus well-needed. Thermal analyses have been used to characterize SOM among which Rock-Eval 6 (RE6) analysis of soil has shown promising results in the determination of SOM biogeochemical stability (Gregorich et al., 2015; Barré et al., 2016). Using a large set of samples of French forest soils representing contrasted pedoclimatic conditions, including deep samples (up to 1 m depth), we compared different techniques used for SOM lability assessment. We explored whether results from soil respiration test (10-week laboratory incubations), SOM size-density fractionation and RE6 thermal analysis were comparable and how they were correlated. A set of 222 (respiration test and RE6), 103 (SOM fractionation and RE6) and 93 (respiration test, SOM fractionation and RE6) forest soils samples were respectively analyzed and compared. The comparison of the three methods (n = 93) using a principal component analysis separated samples from the surface (0-10 cm) and deep (40-80 cm) layers, highlighting a clear effect of depth on the short-term persistence of SOC. A correlation analysis demonstrated that, for these samples, the two classical methods of labile SOC determination (respiration and SOM fractionation

  16. Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

    DEFF Research Database (Denmark)

    Karlsen, Allan Ertman; Heding, P E; Frobøse, H

    2004-01-01

    The proinflammatory cytokine IL-1beta induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-kappaB (NF-kappaB), mitogen-activated protein kinase, and protein kinase C. We recently showed suppressor of cytokine signalling (SOCS)-3 to be a natural negative feedback reg...... regulator of IL-1beta- and IFN-gamma-mediated signalling in rat islets and beta cell lines, preventing their deleterious effects. However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown....

  17. The Library International Partnerweek 2011

    DEFF Research Database (Denmark)

    Presentation at the Library International Partnerweek, held at Copenhagen Technical Library at the Copenhagen University College of Engineering. Participant: Ms. Carmen Priesto Estravid from Madrid Technical University, E.U.I.T. Obras Públicas, Library. Spain Ms.Tuulikki Hattunen from TUAS Library....... Finland Ms. Anitta Ôrm from Kemi-Tornio UAS Library. Finland Mr. Manfred Walter from HTW-Berlin. Germany Mr. Peter Hald from Copenhagen Technical Library. Denmark Mr. Ole Micahelsen from Copenhagen Technical Library. Denmark...

  18. Benefits of International Collaboration on the International Space Station

    Science.gov (United States)

    Hasbrook, Pete; Robinson, Julie A.; Brown Tate, Judy; Thumm, Tracy; Cohen, Luchino; Marcil, Isabelle; De Parolis, Lina; Hatton, Jason; Umezawa, Kazuo; Shirakawa, Masaki; hide

    2017-01-01

    The International Space Station is a valuable platform for research in space, but the benefits are limited if research is only conducted by individual countries. Through the efforts of the ISS Program Science Forum, international science working groups, and interagency cooperation, international collaboration on the ISS has expanded as ISS utilization has matured. Members of science teams benefit from working with counterparts in other countries. Scientists and institutions bring years of experience and specialized expertise to collaborative investigations, leading to new perspectives and approaches to scientific challenges. Combining new ideas and historical results brings synergy and improved peer-reviewed scientific methods and results. World-class research facilities can be expensive and logistically complicated, jeopardizing their full utilization. Experiments that would be prohibitively expensive for a single country can be achieved through contributions of resources from two or more countries, such as crew time, up- and downmass, and experiment hardware. Cooperation also avoids duplication of experiments and hardware among agencies. Biomedical experiments can be completed earlier if astronauts or cosmonauts from multiple agencies participate. Countries responding to natural disasters benefit from ISS imagery assets, even if the country has no space agency of its own. Students around the world participate in ISS educational opportunities, and work with students in other countries, through open curriculum packages and through international competitions. Even experiments conducted by a single country can benefit scientists around the world, through specimen sharing programs and publicly accessible "open data" repositories. For ISS data, these repositories include GeneLab and the Physical Science Informatics System. Scientists can conduct new research using ISS data without having to launch and execute their own experiments. Multilateral collections of research

  19. Internal and International Migration Across the Urban Hierarchy in Albania.

    Science.gov (United States)

    Lerch, Mathias

    2016-01-01

    The interactions between the processes of urbanization and international migration in less developed and transition countries have important repercussions for socioeconomic development, but are not well understood. Based on the retrospective data from the Albanian Living Standards Measurement Survey 2008, we first assess the geography of migration in terms of the rural-urban continuum, the urban hierarchy and the outside world since 1990. We then investigate the spatio-temporal diffusion of rural-to-urban and international movements using survival models. Results reveal an immediate onset of large-scale rural exodus, despite the post-communist crisis. Internal migrants mainly moved to the capital, bypassing secondary cities, and were predominantly female. Initially, international migrants were primarily men who tended to originate from the main urban agglomerations. The diffusion of opportunities to emigrate down the urban hierarchy and across the sexes then redirected the rural exodus abroad, despite domestic economic development. This evolution in population mobility is related to the gendered patterns and interlinkages of the two flows, as well as to rising inequalities within the urban hierarchy.

  20. SoCRocket: A Virtual Platform for SoC Design

    Science.gov (United States)

    Fossati, Luca; Schuster, Thomas; Meyer, Rolf; Berekovic, Mladen

    2013-08-01

    Both in the commercial and in the aerospace domain, the continuous increase of transistor density on a single die is leading towards the production of more and more complex systems on a single chip, with an increasing number of components. This brought to the introduction of the System-On-Chip (SoC) architecture, that integrates on a single circuit all the elements of a full system. This strive for efficient utilization of the available silicon has triggered several paradigm shifts in system design. Similarly to what happened in the early 1990s, when VHDL and Verilog took over from schematic design, today SystemC and Transaction Level Modeling [1] are about to further raise the design abstraction level. Such descriptions have to be accurate enough to describe the entire system throughout the phases of its development, and has to provide enough flexibility to be refined iteratively up to the point where the actual device can be produced using current process technology. Besides requiring new languages and methodologies, the complexity of current and future SoCs (SCOC3 [16] and NGMP [5] are example in the space domain) forces the SoC design process to rely on pre-designed or third party components. Components obtained from different providers, and even those designed by different teams of the same company, may be heterogeneous on several aspects: design domains, interfaces, abstraction levels, granularity, etc. Therefore, component integration is required at system level. Only by applying design re-use it is possible to successfully and timely design such complex SoCs. This transition to new languages and design methods is also motivated by the implementation with software of an increasing amount of system functionalities. Hence the need for methodologies to enable early software development and which allow the analysis of the performance of the combined Hw/Sw system, as their design and configuration cannot be performed separately. Virtual Prototyping is a key

  1. International ties. [international cooperation in the space sciences

    Science.gov (United States)

    1980-01-01

    A historical overview of NASA's participation in international activities in space science is given. The Ariel, Alouette, Isis, and San Marco satellite programs are addressed along with sounding rocket and ground based projects. Relations and cooperation with the Soviet Union are also discussed.

  2. The International Legal Personality of the Individual

    DEFF Research Database (Denmark)

    Kjeldgaard-Pedersen, Astrid

    This book scrutinizes the relationship between the concept of international legal personality as a theoretical construct and the position of the individual as a matter of positive international law. By testing four main theoretical conceptions of international legal personality against historical...... to transform during the second half of the twentieth century so as to include individuals as its subjects. Rather, the answer to the question of individual rights and obligations under international law is—and always was—solely contingent upon the interpretation of international legal norms. It follows......, of course, that the entities governed by a particular norm tell us nothing about the legal system to which that norm belongs. Instead, the distinction between international and national legal norms turns exclusively on the nature of their respective sources. Against the background of these insights...

  3. Yellowcake: the international uranium cartel

    International Nuclear Information System (INIS)

    Taylor, J.H.; Yokell, M.D.

    1979-01-01

    The dramatic events that occurred in the uranium market between 1972 and 1976, and their repercussions is discussed. In particular, the book concentrates on the international uranium cartel's attempt to fix yellowcake prices. The background of the yellowcake industry is discussed in Part I of the book, and the demand for uranium and the nuclear fuel cycle isdiscussed, along with a brief anecdotal history of the uranium industry. Part II describes the political conflicts in Australia which led to the public exposure of the uranium cartel and the situation in the world uranium market that led to the cartel's formation. The legal repercussions of the cartel's exposure are discussed in Part III, and in Part IV, the authors reflect on the ramifications of the events described in the book and some of the issues they raise

  4. The international politics of geoengineering:

    DEFF Research Database (Denmark)

    Corry, Olaf

    2017-01-01

    the politics of climate change dramatically, yet in evaluating whether they might ultimately reduce climate risks, their political and security implications have so far not been given adequate prominence. This article puts forward what it calls the ‘security hazard’ and argues that this could be a crucial...... factor in determining whether a technology is able, ultimately, to reduce climate risks. Ideas about global governance of geoengineering rely on heroic assumptions about state rationality and a generally pacific international system. Moreover, if in a climate engineered world weather events become...

  5. The International Reactor Dosimetry File (IRDF-85)

    International Nuclear Information System (INIS)

    Cullen, D.E.; McLaughlin, P.K.

    1985-04-01

    This document describes the contents of the second version of the International Reactor Dosimetry File (IRDF-85), distributed by the Nuclear Data Section of the International Atomic Energy Agency. This library superseded IRDF-82. (author)

  6. The "old internationals": Canadian nurses in an international nursing community.

    Science.gov (United States)

    Lapeyre, Jaime; Nelson, Sioban

    2010-12-01

    The vast devastation caused by both the First World War and the influenza pandemic of 1918 led to an increased worldwide demand for public health nurses. In response to this demand, a number of new public health training programs for nurses were started at both national and international levels. At the international level, one of two influential programs in this area included a year-long public health nursing course offered by the League of Red Cross Societies, in conjunction with Bedford College in London, England. In total, 341 nurses from 49 different countries have been documented as participants in this initiative throughout the interwar period, including 20 Canadians. Using archival material from the Canadian Nurses Association and the Royal College of Nursing, as well as articles from the journals Canadian Nurse, American Journal of Nursing and British Journal of Nursing, this paper examines these nurses' commitment to internationalism throughout their careers and explores the effect of this commitment on the development of nursing education and professionalization at the national level.

  7. The International Technical Safety Forum

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    The International Technical Safety Forum is a meeting of safety experts from several physics labs in Europe and the US. Since 1998 participants have been meeting every couple of years to discuss common challenges in safety matters. The Forum helps them define best practices and learn from the important lessons learned by others.   The Forum's participants in front of building 40. This year, the meeting took place at CERN from 12 to 16 April. “This year's meeting covered subjects ranging from communication and training in matters of safety, to cryogenic safety, emergency preparedness and risk analysis”, explains Ralf Trant, head of the CERN Safety Commission and organiser of this year’s Forum. Radiation protection issues are not discussed at the meeting since they involve different expertise. The goal of the Forum is to allow participants to share experience, learn lessons and acquire specific knowledge in a very open way. Round-table discussions, dedicated time for ...

  8. The Environment in International Relations

    Science.gov (United States)

    Young, Oran R.

    2009-11-01

    In this lucid and well-organized text, Kate O'Neill provides a survey of current thinking in the field of international environmental politics. To make her effort manageable, she approaches this task as an analysis of the “politics of global environmental governance” (p. 1). This approach has the effect of orienting the survey toward research on efforts to develop cooperative and lasting solutions to a variety of environmental problems. The downside of this approach is a relative lack of emphasis on various forms of environmental conflict that lead to outcomes such as growth in the number of environmental refugees and the destruction of important ecosystems. But the virtue of the decision to focus on environmental governance is that it provides a coherent and easily understandable framework for the chapters that follow.

  9. THE INTERNAL CONTROL MODELS IN ROMANIA

    Directory of Open Access Journals (Sweden)

    TEODORESCU CRISTIAN DRAGOȘ

    2015-06-01

    Full Text Available Internal control is indissolubly linked to business and accounting. Throughout history, domestic and international trade has grown exponentially, which has led to an increasing complexity of internal control, to new methods and techniques to control the business. The literature has presented the first models of internal control in the Sumerian period (3600 - 3200 BC, and the emergence and development of internal control in Egypt, Persia, Greek and Roman Empire, in the Middle Ages till modern times. The purpose of this article is to present the models of internal control in Romania, starting from the principles of the classical model of internal control (COSO model. For a better understanding of the implication of internal control in terms of public and private sector, I have structured the article in the following parts: (a the definition of internal control in the literature; (b the presentation of the COSO model; (c internal control and internal audit in public institutions; (d internal control issues in accounting regulations on the individual and consolidated annual financial statements; (e internal / managerial control; (f conclusions.

  10. The precautionary principle in international environmental law and international jurisprudence

    OpenAIRE

    Tubić, Bojan

    2014-01-01

    This paper analysis international regulation of the precautionary principle as one of environmental principles. This principle envisages that when there are threats of serious and irreparable harm, as a consequence of certain economic activity, the lack of scientific evidence and full certainty cannot be used as a reason for postponing efficient measures for preventing environmental harm. From economic point of view, the application of precautionary principle is problematic, because it create...

  11. China and the New International Order

    DEFF Research Database (Denmark)

    Jiang, Yang

    2009-01-01

    This article reviews the book "China and the New International Order," edited by Wang Gungwu and Zheng Yongnian.......This article reviews the book "China and the New International Order," edited by Wang Gungwu and Zheng Yongnian....

  12. International Research Results and Accomplishments From the International Space Station

    Science.gov (United States)

    Ruttley, Tara M.; Robinson, Julie A.; Tate-Brown, Judy; Perkins, Nekisha; Cohen, Luchino; Marcil, Isabelle; Heppener, Marc; Hatton, Jason; Tasaki, Kazuyuki; Umemura, Sayaka; hide

    2016-01-01

    In 2016, the International Space Station (ISS) partnership published the first-ever compilation of international ISS research publications resulting from research performed on the ISS through 2011. The International Space Station Research Accomplishments: An Analysis of Results From 2000-2011 is a collection of summaries of over 1,200 journal publications that describe ISS research in the areas of biology and biotechnology; Earth and space science; educational activities and outreach; human research; physical sciences; technology development and demonstration; and, results from ISS operations. This paper will summarize the ISS results publications obtained through 2011 on behalf of the ISS Program Science Forum that is made up of senior science representatives across the international partnership. NASA's ISS Program Science office maintains an online experiment database (www.nasa.gov/issscience) that tracks and communicates ISS research activities across the entire ISS partnership, and it is continuously updated. It captures ISS experiment summaries and results and includes citations to the journals, conference proceedings, and patents as they become available. The International Space Station Research Accomplishments: An Analysis of Results From 2000-2011 is a testament to the research that was underway even as the ISS laboratory was being built. It reflects the scientific knowledge gained from ISS research, and how it impact the fields of science in both space and traditional science disciplines on Earth. Now, during a time when utilization is at its busiest, and with extension of the ISS through at least 2024, the ISS partners work together to track the accomplishments and the new knowledge gained in a way that will impact humanity like no laboratory on Earth. The ISS Program Science Forum will continue to capture and report on these results in the form of journal publications, conference proceedings, and patents. We anticipate that successful ISS research will

  13. Relationship between the international marketing research and the international marketing information system

    Directory of Open Access Journals (Sweden)

    Grubor Aleksandar

    2004-01-01

    Full Text Available Real and complete understanding relationship between the international marketing research and the international marketing information system requires recognizing essentials of the both concept. The international marketing research constitutes a process with coherent phases, whereas the international marketing information system is a part of integrated company's information system. Approach to learning relationship between the international marketing research and the international marketing information system is distinguish in domestic than in the foreign expert literature.

  14. Report: Fourth International Conference on Gas Hydrates, held at Yokohama, Japan, 19-23 May 2002

    Digital Repository Service at National Institute of Oceanography (India)

    Karisiddaiah, S.M.

    formations, while Dr. L. Stern presented ne insights into the phenomena of anomalous or self- preservation of gas hydrates. JOUR.GEOL.SOC.INDIA, VOL.61, JAN. 2001 Posters on hydrate formation and prevention in pipelines and hydrate based...-1 REPORT ON THE 4TH INTERNATIONAL CONFERENCE ON GAS HYDRATES The fourth International Conference on Gas Hydrates was recently held at Yokohama, Japan, between 19-23 May 2002 following the earlier conferences held in USA (1993...

  15. Implementation of SoC Based Real-Time Electromagnetic Transient Simulator

    Directory of Open Access Journals (Sweden)

    I. Herrera-Leandro

    2017-01-01

    Full Text Available Real-time electromagnetic transient simulators are important tools in the design stage of new control and protection systems for power systems. Real-time simulators are used to test and stress new devices under similar conditions that the device will deal with in a real network with the purpose of finding errors and bugs in the design. The computation of an electromagnetic transient is complex and computationally demanding, due to features such as the speed of the phenomenon, the size of the network, and the presence of time variant and nonlinear elements in the network. In this work, the development of a SoC based real-time and also offline electromagnetic transient simulator is presented. In the design, the required performance is met from two sides, (a using a technique to split the power system into smaller subsystems, which allows parallelizing the algorithm, and (b with specialized and parallel hardware designed to boost the solution flow. The results of this work have shown that for the proposed case studies, based on a balanced distribution of the node of subsystems, the proposed approach has decreased the total simulation time by up to 99 times compared with the classical approach running on a single high performance 32-bit embedded processor ARM-Cortex A9.

  16. Novel sampling methods for atmospheric semi-volatile organic compounds (SOCs) in a high altitude alpine environment.

    Science.gov (United States)

    Offenthaler, I; Jakobi, G; Kaiser, A; Kirchner, M; Kräuchi, N; Niedermoser, B; Schramm, K-W; Sedivy, I; Staudinger, M; Thanner, G; Weiss, P; Moche, W

    2009-12-01

    High- and low-volume active air samplers as well as bulk deposition samplers were developed to sample atmospheric SOCs under the adverse conditions of a mountain environment. Active sampling employed separate filters for different European source regions. Filters were switched depending on daily trajectory forecasts, whose accuracy was evaluated post hoc. The sampling continued on three alpine summits over five periods of four months. The prevailing trajectories varied stronger between sampling periods than between stations. The sampling equipment (active and bulk deposition) proved dependable for operation in a mountain environment, with idle times being mainly due to non-routine manipulations and connectivity.

  17. The international exercise INEX-4 in Spain

    International Nuclear Information System (INIS)

    Garcia Cadierno, J. P.

    2011-01-01

    international series of exercises developed by INEX Nuclear Energy Agency, under the Organization for Economic Cooperation and Development (OECD) had focused on national and international aspects of managing the first phase of nuclear emergencies and these proved useful for testing, research and improve the necessary arrangements for responding to nuclear accidents and radiological emergencies at the national and international levels.

  18. The Biosphere International Peer Review

    International Nuclear Information System (INIS)

    Van Luik, Abraham

    2002-01-01

    Abe van Luik (US DOE- YM, USA), ended the presentation by giving feedback from the IAEA peer review on the biosphere modelling strategy developed by the DOE Yucca Mountain Site Characterisation Office (YMSCO). This review was based on available international standards and guidance. The peer review team was constituted of both experts from regulatory and waste management organisations and national advisory committees. The implementation of the review consisted of an examination of biosphere reports mainly regarding the modelling and question and answer exchanges. The final report was submitted in April 2000. It contained twenty-three recommendations within two broad classifications; one concerning the regulatory framework, the other one regarding the framework to increase stakeholders' confidence in modelling. The three main categories of recommendations were outlined, namely (i) the DOE' s Biosphere assessment Approach, (ii) the definition of the biosphere system, and (iii) the model development, data and results. Regarding in particular the treatment of the uncertainties in the biosphere, it was viewed as a key issue during the review and thus it will be re-evaluated in the future performance assessment. The summary highlighted most of the recommendations received are to be acted on, and are to be included in the License Application plan for biosphere modelling

  19. Technology-design-manufacturing co-optimization for advanced mobile SoCs

    Science.gov (United States)

    Yang, Da; Gan, Chock; Chidambaram, P. R.; Nallapadi, Giri; Zhu, John; Song, S. C.; Xu, Jeff; Yeap, Geoffrey

    2014-03-01

    How to maintain the Moore's Law scaling beyond the 193 immersion resolution limit is the key question semiconductor industry needs to answer in the near future. Process complexity will undoubtfully increase for 14nm node and beyond, which brings both challenges and opportunities for technology development. A vertically integrated design-technologymanufacturing co-optimization flow is desired to better address the complicated issues new process changes bring. In recent years smart mobile wireless devices have been the fastest growing consumer electronics market. Advanced mobile devices such as smartphones are complex systems with the overriding objective of providing the best userexperience value by harnessing all the technology innovations. Most critical system drivers are better system performance/power efficiency, cost effectiveness, and smaller form factors, which, in turns, drive the need of system design and solution with More-than-Moore innovations. Mobile system-on-chips (SoCs) has become the leading driver for semiconductor technology definition and manufacturing. Here we highlight how the co-optimization strategy influenced architecture, device/circuit, process technology and package, in the face of growing process cost/complexity and variability as well as design rule restrictions.

  20. The Cambridge Companion to International Law

    Directory of Open Access Journals (Sweden)

    Achmad Gusman Siswandi

    2014-08-01

    Full Text Available ABSTRAK This book provides a thorough introduction to international law in a way that is rather unique compared to similar references. The subject matteris divided in a more concise way, while still giving rich perspective as it covers not only theories but also case studies and practices. This book consists of four parts, namely: the contexts of international law; international law and the state; techniques and arenas; and projects of international law.

  1. International

    International Nuclear Information System (INIS)

    Anon.

    1997-01-01

    This rubric reports on 10 short notes about international economical facts about nuclear power: Electricite de France (EdF) and its assistance and management contracts with Eastern Europe countries (Poland, Hungary, Bulgaria); Transnuclear Inc. company (a 100% Cogema daughter company) acquired the US Vectra Technologies company; the construction of the Khumo nuclear power plant in Northern Korea plays in favour of the reconciliation between Northern and Southern Korea; the delivery of two VVER 1000 Russian reactors to China; the enforcement of the cooperation agreement between Euratom and Argentina; Japan requested for the financing of a Russian fast breeder reactor; Russia has planned to sell a floating barge-type nuclear power plant to Indonesia; the control of the Swedish reactor vessels of Sydkraft AB company committed to Tractebel (Belgium); the renewal of the nuclear cooperation agreement between Swiss and USA; the call for bids from the Turkish TEAS electric power company for the building of the Akkuyu nuclear power plant answered by three candidates: Atomic Energy of Canada Limited (AECL), Westinghouse (US) and the French-German NPI company. (J.S.)

  2. The Challenges of Adopting International Financial Reporting ...

    African Journals Online (AJOL)

    The Challenges of Adopting International Financial Reporting System in Nigeria. ... Nigeria is going to adopt International Financial Reporting Standard (IFRS) ... its challenges and to proffer solutions that would ensure seamless transition in ...

  3. The energy services market in France

    International Nuclear Information System (INIS)

    2004-06-01

    This study aims to answer the following questions: what is the french market value? What are its development perspectives? What services range is necessary? How increase the added value of proposed services? Which choice between the competence internalization and the subcontracting? What threat represent the providers on a market usually dominated by the energy suppliers and services providers? How will the french and european market combine? The following operators are studied (key data, energy services policy) by Eurostaf: Amec Spie, Cegelec, Dalkia, EDF, Elyo, Endesa Energia, Energie Rhone, GDF, RWE Solutions, Vinci Energies. (A.L.B.)

  4. Prabowo and the shortcomings of international justice

    DEFF Research Database (Denmark)

    Tan, Nikolas Feith

    2015-01-01

    under the jurisdiction of the International Criminal Court, temporal jurisdiction renders prosecution impossible. This article explores Prabowo’s human rights abuses, and how international criminal law has failed to achieve justice for these crimes. It concludes that Prabowo’s political rise threatens...... the aims of international criminal justice....

  5. Report of the Committee on International Education.

    Science.gov (United States)

    Colorado Commission on Higher Education, Denver.

    The purpose of this report is to promote further development of international education in Colorado through the expansion of foreign language instruction, student and faculty exchanges, enrollment of international students, collaboration with state and private sector entities in international commerce, and the establishment of consortia…

  6. The International Atomic Energy Agency's safeguards system

    International Nuclear Information System (INIS)

    Wagner, W.

    2000-01-01

    A system of international safeguards has been established to provide assurance that nuclear materials in civilian use are not diverted from their peaceful purpose. The safeguards system is administered by the International Atomic Energy Agency/Department of Safeguards and devolves from treaties and other international agreements. Inspectors from the Agency verify reports from States about nuclear facilities by audits, observation, and measurements. (author)

  7. International Cooperation of Payload Operations on the International Space Station

    Science.gov (United States)

    Melton, Tina; Onken, Jay

    2003-01-01

    One of the primary goals of the International Space Station (ISS) is to provide an orbiting laboratory to be used to conduct scientific research and commercial products utilizing the unique environment of space. The ISS Program has united multiple nations into a coalition with the objective of developing and outfitting this orbiting laboratory and sharing in the utilization of the resources available. The primary objectives of the real- time integration of ISS payload operations are to ensure safe operations of payloads, to avoid mutual interference between payloads and onboard systems, to monitor the use of integrated station resources and to increase the total effectiveness of ISS. The ISS organizational architecture has provided for the distribution of operations planning and execution functions to the organizations with expertise to perform each function. Each IPP is responsible for the integration and operations of their payloads within their resource allocations and the safety requirements defined by the joint program. Another area of international cooperation is the sharing in the development and on- orbit utilization of unique payload facilities. An example of this cooperation is the Microgravity Science Glovebox. The hardware was developed by ESA and provided to NASA as part of a barter arrangement.

  8. The international surface temperature initiative

    Science.gov (United States)

    Thorne, P. W.; Lawrimore, J. H.; Willett, K. M.; Allan, R.; Chandler, R. E.; Mhanda, A.; de Podesta, M.; Possolo, A.; Revadekar, J.; Rusticucci, M.; Stott, P. A.; Strouse, G. F.; Trewin, B.; Wang, X. L.; Yatagai, A.; Merchant, C.; Merlone, A.; Peterson, T. C.; Scott, E. M.

    2013-09-01

    The aim of International Surface Temperature Initiative is to create an end-to-end process for analysis of air temperature data taken over the land surface of the Earth. The foundation of any analysis is the source data. Land surface air temperature records have traditionally been stored in local, organizational, national and international holdings, some of which have been available digitally but many of which are available solely on paper or as imaged files. Further, economic and geopolitical realities have often precluded open sharing of these data. The necessary first step therefore is to collate readily available holdings and augment these over time either through gaining access to previously unavailable digital data or through data rescue and digitization activities. Next, it must be recognized that these historical measurements were made primarily in support of real-time weather applications where timeliness and coverage are key. At almost every long-term station it is virtually certain that changes in instrumentation, siting or observing practices have occurred. Because none of the historical measures were made in a metrologically traceable manner there is no unambiguous way to retrieve the true climate evolution from the heterogeneous raw data holdings. Therefore it is desirable for multiple independent groups to produce adjusted data sets (so-called homogenized data) to adequately understand the data characteristics and estimate uncertainties. Then it is necessary to benchmark the performance of the contributed algorithms (equivalent to metrological software validation) through development of realistic benchmark datasets. In support of this, a series of successive benchmarking and assessment cycles are envisaged, allowing continual improvement while avoiding over-tuning of algorithms. Finally, a portal is proposed giving access to related data-products, utilizing the assessment results to provide guidance to end-users on which product is the most suited to

  9. The international dimensions of nuclear safety standards

    International Nuclear Information System (INIS)

    Reed, J.M.

    1992-01-01

    The paper reviews the activities of the major international organisations in the field of nuclear safety standards; the International Atomic Energy Agency (IAEA), the OECD's Nuclear Energy Agency (NEA) and the Commission of the European Communities. Each organisation encourages the concept of international nuclear safety standards. After Chernobyl, there were calls for some form of binding international nuclear safety standards. Many Member States of IAEA accepted these Codes as a suitable basis for formulating their national safety standards, but the prevailing view was that voluntary compliance with the Codes was the preferred path. With few reactor vendors in a limited international market, the time may be approaching when an internationally licensable nuclear reactor is needed. Commonly accepted safety standards would be a prerequisite. The paper discusses the issues involved and the complexities of standards making in the international arena. (author)

  10. Co-verification of hardware and software for ARM SoC design

    CERN Document Server

    Andrews, Jason

    2004-01-01

    Hardware/software co-verification is how to make sure that embedded system software works correctly with the hardware, and that the hardware has been properly designed to run the software successfully -before large sums are spent on prototypes or manufacturing. This is the first book to apply this verification technique to the rapidly growing field of embedded systems-on-a-chip(SoC). As traditional embedded system design evolves into single-chip design, embedded engineers must be armed with the necessary information to make educated decisions about which tools and methodology to deploy. SoC verification requires a mix of expertise from the disciplines of microprocessor and computer architecture, logic design and simulation, and C and Assembly language embedded software. Until now, the relevant information on how it all fits together has not been available. Andrews, a recognized expert, provides in-depth information about how co-verification really works, how to be successful using it, and pitfalls to avoid. H...

  11. International cooperation on the environment

    Energy Technology Data Exchange (ETDEWEB)

    Lange, V de [Amsterdam University, Amsterdam (Netherlands). Interfaculty Dept. of Environmental Science

    1993-01-01

    For centuries there has been international trade, but since the enormous growth in production, the goods we produce have begun to pollute the global environment. Feed for Dutch cattle is grown in South-East Asia, leading to a manure surplus here and soil erosion there. To provide the Dutch with aluminium for their beer cans, large areas of Brazilian rainforest have been cleared, while the waste mountain grows ever larger in Netherlands. It has been clear since the 1970s that the countries of the world are working in tandem to pollute the environment we all rely on. Similarly, we have to work together to clean it up. Although we are nowhere near a solution, many forms of cooperation have seen the light of day, from global agreements like Agenda 21 to simple declarations by the governments of two countries. The Netherlands has entered into thirteen such small-scale environmental agreements, or memoranda of understanding as they are known. The aim of these agreements is to reinforce each others' environmental management structure. In practice, this modest approach has been found to suit ambitious aims like redistribution of environmental space. The motto is 'small is beautiful'.

  12. International cooperation on the environment

    International Nuclear Information System (INIS)

    Lange, V. de

    1993-01-01

    For centuries there has been international trade, but since the enormous growth in production, the goods we produce have begun to pollute the global environment. Feed for Dutch cattle is grown in South-East Asia, leading to a manure surplus here and soil erosion there. To provide the Dutch with aluminium for their beer cans, large areas of Brazilian rainforest have been cleared, while the waste mountain grows ever larger in Netherlands. It has been clear since the 1970s that the countries of the world are working in tandem to pollute the environment we all rely on. Similarly, we have to work together to clean it up. Although we are nowhere near a solution, many forms of cooperation have seen the light of day, from global agreements like Agenda 21 to simple declarations by the governments of two countries. The Netherlands has entered into thirteen such small-scale environmental agreements, or memoranda of understanding as they are known. The aim of these agreements is to reinforce each others' environmental management structure. In practice, this modest approach has been found to suit ambitious aims like redistribution of environmental space. The motto is 'small is beautiful'

  13. The Role of International Law: Formulating International Legal Instruments and Creating International Institutions.

    Science.gov (United States)

    Szasz, Paul C.

    1991-01-01

    Using as a basis the threat of climatic change resulting from global warming, this article considers the functions that might be assigned to an international regime. For each function individually and collectively, the instruments and institutions that would be required for the various processes are examined. (SLD)

  14. The euro: an international currency

    International Nuclear Information System (INIS)

    Riley, D.

    2000-01-01

    A number of studies and reports are now readily available on how to come grips the Euro - its calendar, conversion factors, legal, financial and accounting aspects, and so forth. Typically, they point to a fixed-for-ever rate of exchange between participating countries, which of course may have strategic consequences for the location of many types of business. This survey does not seek to be exhaustive, nor to cover what is well documented elsewhere. Rather, it attempts to examine areas where uncertainty, or controversy continue to exist, as well as focus on aspects that are pertinent to the oil and gas industries. Two questions stand out. The first is a general one, concerning how the Euro is likely to fare in international currency markets, notably relative to the US Dollar. The second is closely linked to the first, but is specific to the hydrocarbons business: will European oil and gas prices be quoted in euros and, if so, over what time frame? Finally, this review looks briefly at a selection of other impacts relevant to the energy business

  15. An Elongin-Cullin-SOCS Box Complex Regulates Stress-Induced Serotonergic Neuromodulation

    Directory of Open Access Journals (Sweden)

    Xicotencatl Gracida

    2017-12-01

    Full Text Available Neuromodulatory cells transduce environmental information into long-lasting behavioral responses. However, the mechanisms governing how neuronal cells influence behavioral plasticity are difficult to characterize. Here, we adapted the translating ribosome affinity purification (TRAP approach in C. elegans to profile ribosome-associated mRNAs from three major tissues and the neuromodulatory dopaminergic and serotonergic cells. We identified elc-2, an Elongin C ortholog, specifically expressed in stress-sensing amphid neuron dual ciliated sensory ending (ADF serotonergic sensory neurons, and we found that it plays a role in mediating a long-lasting change in serotonin-dependent feeding behavior induced by heat stress. We demonstrate that ELC-2 and the von Hippel-Lindau protein VHL-1, components of an Elongin-Cullin-SOCS box (ECS E3 ubiquitin ligase, modulate this behavior after experiencing stress. Also, heat stress induces a transient redistribution of ELC-2, becoming more nuclearly enriched. Together, our results demonstrate dynamic regulation of an E3 ligase and a role for an ECS complex in neuromodulation and control of lasting behavioral states.

  16. The International Thermonuclear Experimental Reactor (ITER) international organisation: which laws apply to this international nuclear operator?

    International Nuclear Information System (INIS)

    Grammatico-Vidal, L.

    2009-01-01

    ITER is being carried out by way of international collaboration between seven partners (the European atomic energy community -EURATOM-, China, India, Japan, Russia, south korea and the United states) which together represent more than half the world population. From a project organisation point of view, it is supported by both financial and in-kind contributions provided by each of the partner; each member makes its contribution through a special legal entity called a 'domestic agency' to an international organisation which was set up by the Agreement on the Establishment of an International Fusion Energy Organization for the joint Implementation of the ITER project signed in Paris on 21. november 2006 and which entered into force on 24. october 2007 after ratification by each of the partners. The international agreement is to remain in effect for a period of 35 years and may be renewed for a period of 10 years without any change to its content. It is supplemented by an agreement of the same date on the privileges and immunities of the organisation and of its staff. The function of the ITER organisation is to construct, commission, operate and permanently shutdown the ITER facility, to encourage their exploitation by laboratories, other institutions and personnel participating in the fusion energy research and development programmes of its members and to promote public understanding and acceptance of fusion energy. The unique institutional structure for this project will be described briefly in the introduction before analysing the law applicable to this international organisation, a French nuclear operator, unique in France today. (N.C.)

  17. International study for an international career: a survey of the motivations and aspirations of international students in the UK

    OpenAIRE

    Packwood, Helen; Findlay, Allan; McCollum, David

    2015-01-01

    There are currently 435,000 international students studying in UK Universities. This paper investigates the forces driving student mobility and the relationship between student migration and future mobility plans. The research, based on a survey of over 3000 international students and interviews with senior staff in International Offices at ten UK Universities confirms the importance of understanding international student mobility as part of wider mobility trajectories.

  18. The Political Economy of International Transitional Administration

    DEFF Research Database (Denmark)

    Grasten, Maj Lervad; Tzouvala, Ntina

    2018-01-01

    This article reconstructs how democratic participation and interference can be fended off by the construction of an international authoritarian political architecture and a strongly legalised and specific form of market economy. We do this by interrogating International Territorial Administration...... corporations. Even though the two administrations focused on different aspects of land and agriculture regulation, we argue that significant commonalities exist between their political preferences and interests. Our work draws on the tradition of critical legal studies in International Law (IL) and we posit...... that by drawing on this tradition, scholarship on post-conflict international territorial administration is better able to capture the long-term ramifications of international intervention....

  19. The enterprises reorganization in the international trade

    Directory of Open Access Journals (Sweden)

    José Ultemar da Silva

    2007-12-01

    Full Text Available This present article aims to make an approach to the international trade, showing the competitiveness in the business world, as well as the companies/enterprises need in preparing themselves to face the great competition in the international trade, into a more and more globalized and competitive environment. At the ending 90’s, facing to crises and so many other economic models, some Brazilian enterprises began to adopt an undertaken-mindedness searching insertion in the global market.

  20. One-chip Integrated Module of MEMS Shock Sensor and Sensing Amplifier LSI using Pseudo-SOC Technology

    Science.gov (United States)

    Iida, Atsuko; Onozuka, Yutaka; Nishigaki, Michihiko; Yamada, Hiroshi; Funaki, Hideyuki; Itaya, Kazuhiko

    We have been developing the pseudo-SOC technology for one-chip module integration of heterogeneous devices that realizes high electrical performance and high density of devices embodying the advantages of both SOC technology and SIP technology. Especially, this technology is available for MEMS-LSI integration. We developed a 0.2mm-thickness one-chip module integrating a MEMS shock sensor and a sensing amplifier LSI by applying this technology. The MEMS shock sensor and the sensing amplifier LSI were connected by high-rigidity epoxy resin optimized the material constants to reduce the stress and the warpage resulting from resin shrinkage due to curing. Then the planar insulating layer and the redistributed conducting layer were formed on it for the global layer. The MEMS shock sensor was preformed to be modularized with a glass cap. Electrical contacts were achieved by bonding of Au bumps on the MEMS fixed electrodes and via holes filled with Ag paste of the glass cap. Functional performance was confirmed by obtaining signal corresponding to the reference signal of the pick-up sensor. Furthermore, stress analysis was performed using the FEM model simulation considering the resin shrinkage.

  1. International criminal justice: a pillar for the international rule of law

    Directory of Open Access Journals (Sweden)

    Gonzalo Aguilar Cavallo

    2012-12-01

    Full Text Available The international criminal justice has experienced a rapid change over the past years. This circumstance has underscored the need for interaction and complementation between international and domestic law. Some authors consider that the international criminal justice, and the activities of its tribunals, jeopardize the legality of international law. Our vision is that international criminal justice is a central pillar of the rule of law, at the national and the international levels. Far from undermining the legality of international law, international criminal justice paves the way towards a true international public order.

  2. Modeling the internal combustion engine

    Science.gov (United States)

    Zeleznik, F. J.; Mcbride, B. J.

    1985-01-01

    A flexible and computationally economical model of the internal combustion engine was developed for use on large digital computer systems. It is based on a system of ordinary differential equations for cylinder-averaged properties. The computer program is capable of multicycle calculations, with some parameters varying from cycle to cycle, and has restart capabilities. It can accommodate a broad spectrum of reactants, permits changes in physical properties, and offers a wide selection of alternative modeling functions without any reprogramming. It readily adapts to the amount of information available in a particular case because the model is in fact a hierarchy of five models. The models range from a simple model requiring only thermodynamic properties to a complex model demanding full combustion kinetics, transport properties, and poppet valve flow characteristics. Among its many features the model includes heat transfer, valve timing, supercharging, motoring, finite burning rates, cycle-to-cycle variations in air-fuel ratio, humid air, residual and recirculated exhaust gas, and full combustion kinetics.

  3. PREFACE: 23rd Congress of the International Commission for Optics (ICO 23)

    Science.gov (United States)

    Salgueiro, J. R.; Flores-Arias, M. T.; Vázquez-Dorrío, J. B.; Guzmán, Á.; Arakawa, Y.

    2015-04-01

    applications of light to the tracking and manipulation of particles. Each day, in addition to plenary talks, nine or ten parallel sessions were held covering advances in both theory and applications of optics and photonics, ranging from quantum optics to technological applications. A total of 190 talks were given. Poster sessions allowed an additional 150 presentations. Congress participants came from every one of the five continents. Included in the conference were three ceremonies for the granting of awards to plenary speakers noted above. Prizes awarded were the ICO Prize, the ICO Galileo Galilei Award, and the IUPAP young scientist Prize in Optics. Two additional prizes were awarded by OSA and SPIE to student's outstanding poster presentations. Summaries of the presentations were available to Congress attendees. In addition, a call was made for submission of elaborated papers to be peer reviewed and published in the Journal of Physics: Conference Series. Conference papers were presented on applied optics, including color science and optomechanics (7 papers), optical imaging (7 papers), biophotonics (2 papers), optical metrology (4 papers), lasers and laser processing (5 papers), optoelectronics and optical communications (6 papers), nonlinear optics (5 papers), quantum optics (4 papers) and education and sustainability (4 papers). We would like to express our gratitude to the Bureau of the International Commission for Optics, the members of the organizing and scientific advisory committees, and to the University of Vigo and the University of Santiago de Compostela for their support and help in the organization of the Conference. We finally want to acknowledge all the authors that have submitted their work to be included in this number and very specially thank all those collaborating persons who acted as reviewers of the papers included in this number for their excellent (and often little recognized) work.

  4. The IOC as an international organization

    Directory of Open Access Journals (Sweden)

    EFTHALIA CHATZIGIANNI

    2006-01-01

    Full Text Available The purpose of this article is to demonstrate the role of the International Olympic Committee as an International Organization in the field of interdependent world politics. Contemporary international community is organized on the basis of international organizations that contribute to the cooperation and understanding of the people especially in areas that enjoy human recognition worldwide. These organizations may function as agents of world solidarity and aim directly or indirectly at the promotion of understanding between people and consequently at the establishment of peace. They also carry out activities that aim at influencing national and international politics relevant to their respective goals. In this field, the IOC, as the most important International Non-Governmental Organization in the field of sport, plays a significant role. With an activity spanning more than a century, the IOC has been able to unify nations under the notion of Olympic ideals. This article aims at contributing partly to the theoretical discussion concerning the ability of the IOC to act as an International Non Governmental Organization and fit in the pieces of world governance in terms of structure and activities. More specifically, it examines this ability in relation to the following facts: a the IOC enjoys international recognition and has a well-established international network, b it has a dynamic character and c it has the authority and financial capacity to function on international and national level as the representative of its 202 members, the National Olympic Committees (NOCs.

  5. Elite International Schools in the Global South: Transnational Space, Class Relationalities and the "Middling" International Schoolteacher

    Science.gov (United States)

    Tarc, Paul; Mishra Tarc, Aparna

    2015-01-01

    The elite international school is a rich site for sociological inquiry in global times. In this paper, we conceptualize the international school as a transnational space of agonist social class-making given the dynamic positioning of the complement of international school actors. We position international schoolteachers in the middle of these…

  6. Argue internal audit on how to promote the nuclear power enterprise internal control

    International Nuclear Information System (INIS)

    Li Xiaoming

    2012-01-01

    In order to strengthen and standardize enterprise internal control, improve the management level and risk prevention ability, five departments jointly established the basic rules of internal control in enterprises, large and medium-sized enterprises as the national power enterprise, the enterprise internal audit executive power in strengthening and perfecting internal control, and in the enterprise internal control of play an active role. (author)

  7. The Evolution of the International Business Field

    DEFF Research Database (Denmark)

    Liesch, Peter W.; Håkanson, Lars; McGaughey, Sara L.

    2011-01-01

    Macro-environmental trends such as technological changes, declining trade and investment barriers, and globalizing forces impacting both markets and production worldwide point to the heightened importance of international business (IB) and the relevance of IB research today. Despite this, a leading...... scholar has expressed concerns that the IB research agenda could be ‘running out of steam’ (Buckley, Journal of International Business Studies 33(2):365–373, 2002), prompting on-going introspection within the IB field. We contribute to this debate by investigating the evolution of the IB field through...... a scientometric examination of articles published in its premier journal, the Journal of International Business Studies (JIBS) from 1970 until 2008. We introduce a new analytical tool, Leximancer, to the fields of international business and scientometry. We show an evolution from an initial and extended emphasis...

  8. Diarrhea in the International Traveler.

    Science.gov (United States)

    Duchini; Rodgers

    1999-06-01

    International travelers to developing countries have a 40% risk of developing a diarrheal illness, usually acute and occasionally chronic. Preventive measures, including diet and lifestyle modifications, are highly recommended but may not be sufficient. Prophylaxis with bismuth subsalicylate or an antimicrobial should be considered in travelers with immunodeficiencies, co-morbid conditions, achlorhydria, or those who cannot afford a loss of time. Oral rehydration is the primary goal of therapy. Bismuth-subsalicylate is a first-line agent for treatment of milder cases with less than three watery bowel movements per day and prominent nausea. Use of an antibiotic is indicated for more severe cases or in the presence of fever, dysentery, or severe dehydration. A short course of a quinolone is highly effective, safe and well tolerated. Antimicrobial resistance among enteropathogens is growing and appropriate therapeutic modifications should be considered according to specific geographic areas. Metronidazole may be empirically added in those cases that do not respond to quinolones. Specific guidelines for particular pathogens are highlighted.

  9. International feedback experience on the cutting of reactor internal components

    International Nuclear Information System (INIS)

    Boucau, J.

    2014-01-01

    Westinghouse capitalizes more than 30 years of experience in the cutting of internal components of reactor and their packaging in view of their storage. Westinghouse has developed and validated different methods for cutting: plasma torch cutting, high pressure abrasive water jet cutting, electric discharge cutting and mechanical cutting. A long feedback experience has enabled Westinghouse to list the pros and cons of each cutting technology. The plasma torch cutting is fast but rises dosimetry concerns linked to the control of the cuttings and the clarity of water. Abrasive water jet cutting requires the installation of costly safety devices and of an equipment for filtering water but this technology allows accurate cuttings in hard-to-reach zones. Mechanical cutting is the most favourable technology in terms of wastes generation and of the clarity of water but the cutting speed is low. (A.C.)

  10. The international climate regime: towards consolidation collapse

    International Nuclear Information System (INIS)

    Berthaud, P.; Cavard, D.; Criqui, P.

    2003-10-01

    This article deals with the different modalities that exist to manage a problem of collective action in the field of climate negotiation. It uses two concepts of the International Political Economy (IPE): the concept of International Regime (IR) and the concept of Hegemony and / or Leadership. The course the international negotiation has taken between 1992 (Rio Convention) and march 2001 (the US rejection of the Kyoto Protocol of 1997) leads us, first, to question the conditions of existence as well as the viability of a non-hegemonic International Regime (Part One). Then, we discuss the perspectives for the 'post - Kyoto' era. After having examined the preferences of the three most active actors in the negotiation (USA, Europe, G77 + China) combined with the leadership capacities they possess, we identify three scenarios for the future: i) anarchy, ii) an international regime under the American hegemony, iii) an international regime under the European leadership (Part Two). (author)

  11. Employers liability to the international criminal court

    Directory of Open Access Journals (Sweden)

    Yenifer Yiseth Suárez Díaz

    2014-01-01

    Full Text Available The constant changes in the social dynamics due to economic and technological development has brought along the need to dispose of a High Court, with competence over International Crimes. The above was the reason to establish the International Criminal Court, destined to prosecute and punish the maximum responsible for crimes of its jurisdiction. Nonetheless, despite the existence of individual criminal responsibility as an accomplice in the case of entrepreneurs who contribute to the crime, there is not an actual investigation or conviction as such in the Court fase for those individuals. Through a criminological study, the actions in the frame of the criminal policy in international law, in order to hold individual criminal responsibility towards entrepreneurs for international crimes, will be evaluated, from the dogmatic categories established in the international guidelines as well as from international doctrine.

  12. A 10-bit 200-kS/s SAR ADC IP core for a touch screen SoC

    International Nuclear Information System (INIS)

    Tong Xingyuan; Yang Yintang; Zhu Zhangming; Sheng Wenfang

    2010-01-01

    Based on a 5 MSBs (most-significant-bits)-plus-5 LSBs (least-significant-bits) C-R hybrid D/A conversion and low-offset pseudo-differential comparison approach, with capacitor array axially symmetric layout topology and resistor string low gradient mismatch placement method, an 8-channel 10-bit 200-kS/s SAR ADC (successive-approximation-register analog-to-digital converter) IP core for a touch screen SoC (system-on-chip) is implemented in a 0.18 μm 1P5M CMOS logic process. Design considerations for the touch screen SAR ADC are included. With a 1.8 V power supply, the DNL (differential non-linearity) and INL (integral non-linearity) of this converter are measured to be about 0.32 LSB and 0.81 LSB respectively. With an input frequency of 91 kHz at 200-kS/s sampling rate, the spurious-free dynamic range and effective-number-of-bits are measured to be 63.2 dB and 9.15 bits respectively, and the power is about 136 μW. This converter occupies an area of about 0.08 mm 2 . The design results show that it is very suitable for touch screen SoC applications. (semiconductor integrated circuits)

  13. The ethics of international animal law

    OpenAIRE

    Kivinen, Tero

    2014-01-01

    This thesis analyzes international animal law, understood broadly as any international legal regulation pertaining to animals. The purpose of the thesis is to explain the moral implications of this branch of international law: how the law perceives the animal and how it believes animals ought to be treated. It attempts to do so by contrasting the law with moral philosophy pertaining to the status and treatment of animals as well as the core characteristics of the branch of animal law found in...

  14. Design and implementation of a reconfigurable mixed-signal SoC based on field programmable analog arrays

    Science.gov (United States)

    Liu, Lintao; Gao, Yuhan; Deng, Jun

    2017-11-01

    This work presents a reconfigurable mixed-signal system-on-chip (SoC), which integrates switched-capacitor-based field programmable analog arrays (FPAA), analog-to-digital converter (ADC), digital-to-analog converter, digital down converter , digital up converter, 32-bit reduced instruction-set computer central processing unit (CPU) and other digital IPs on a single chip with 0.18 μm CMOS technology. The FPAA intellectual property could be reconfigured as different function circuits, such as gain amplifier, divider, sine generator, and so on. This single-chip integrated mixed-signal system is a complete modern signal processing system, occupying a die area of 7 × 8 mm 2 and consuming 719 mW with a clock frequency of 150 MHz for CPU and 200 MHz for ADC/DAC. This SoC chip can help customers to shorten design cycles, save board area, reduce the system power consumption and depress the system integration risk, which would afford a big prospect of application for wireless communication. Project supported by the National High Technology and Development Program of China (No. 2012AA012303).

  15. Hardware-Assisted System for Program Execution Security of SOC

    Directory of Open Access Journals (Sweden)

    Wang Xiang

    2016-01-01

    Full Text Available With the rapid development of embedded systems, the systems’ security has become more and more important. Most embedded systems are at the risk of series of software attacks, such as buffer overflow attack, Trojan virus. In addition, with the rapid growth in the number of embedded systems and wide application, followed embedded hardware attacks are also increasing. This paper presents a new hardware assisted security mechanism to protect the program’s code and data, monitoring its normal execution. The mechanism mainly monitors three types of information: the start/end address of the program of basic blocks; the lightweight hash value in basic blocks and address of the next basic block. These parameters are extracted through additional tools running on PC. The information will be stored in the security module. During normal program execution, the security module is designed to compare the real-time state of program with the information in the security module. If abnormal, it will trigger the appropriate security response, suspend the program and jump to the specified location. The module has been tested and validated on the SOPC with OR1200 processor. The experimental analysis shows that the proposed mechanism can defence a wide range of common software and physical attacks with low performance penalties and minimal overheads.

  16. International Security in the World Economic Relations

    Directory of Open Access Journals (Sweden)

    Otenko Iryna P

    2016-05-01

    Full Text Available The article discusses the urgent topic of the evolution of international relations, the issue of establishing international security, and the development of international economic cooperation based on the principles of security. In order to analyze the current status of international security in the world and to identify key factors that hinder the way of establishing a positive global community, researches by the international analytical centers together with the institutes for international security and cooperation have been generalized. To this end, both the status of and changes in the Global Peace Index in the recent years has been disclosed, the position of Ukraine in the world according to this index has been examined. It has been proven that the main international security problems are related to the armed conflicts, civil wars, political violence, terrorism impacting the development of humanity as a whole, the status of international relations, the evolution of the world economy as well as national economies. Further researches should be focused on how the status of peace in the countries impacts their economic status and the status of international cooperation in other areas of economic cooperation, excluding the military. It should be answered particularly, how the above indicated status affects strengthening the Ukraine's position in the world.

  17. Australia and the International Insolvency Paradigm

    OpenAIRE

    McCormack, G; Hargovan, A

    2015-01-01

    Australia’s response to international insolvency is the Cross-Border Insolvency Act 2008 (Cth), which implements the UNCITRAL Model Law on CrossBorder Insolvency. The Act is designed to facilitate international trade and investment by improving the administration of cross-border insolvency cases, including the recovery of assets located overseas. However, the Act is not a comprehensive international insolvency statute. Apart from the ubiquitous and overarching common law and the Cross-Border ...

  18. The European Union in International Financial Governance

    Directory of Open Access Journals (Sweden)

    Niamh Moloney

    2017-01-01

    Full Text Available This article considers the role of the European Union in international financial governance after the institutional reforms it undertook in connection with the global financial crisis. It suggests that the new administrative actors that support the governance of the European Union's single financial market, notably the European Supervisory Authorities, have the potential to reshape how the European Union engages with international financial governance. It finds that the European Union’s effectiveness in influencing international financial governance—and the effectiveness of international financial governance more generally—is likely to strengthen as a result.

  19. Bull. Chem. Soc. Ethiop. 1996, 10(2)

    African Journals Online (AJOL)

    fingerprint indices are recommended. INTRODUCTION. The ever-increasing discharges .... The gas chromatographic profiles of all the samples are identical, so it may be assumed that these oils are from the same source materials, formed under different geological conditions. The isoprenoid and n-paraffinic composition of ...

  20. Development of a stranded oil in coarse sediment (SOCS) model

    International Nuclear Information System (INIS)

    Humphrey, B.; Owens, E.; Sergy, G.

    1993-01-01

    Oil spills in Canadian waters have a high probability of impacting coarse sediment beaches, yet the ability to predict oil fate and estimate natural self-cleaning rates is less than adequate. Data is lacking to understand fully many oil sediment interactions. Historically, shoreline interactions have been considered using fairly simple concepts. The authors examined the processes that may occur on a coarse sediment beach, selected those which are important, and developed a fate and persistence model for stranded oil. The processes were divided into stages relative to the spill event, and the factors which affect each stage were evaluated. Three areas of special interest were the capacity of a beach to hold oil, the residual capacity of a beach for oil, and the long-term fate of the oil. After developing model algorithms, the outputs were compared to a data base of information collected during the Exxon Valdez oil spill. The stranded oil in coarse sediment model will provide information at two levels: a general level for planning and sensitivity mapping and a more detailed level intended for the prediction of oil fate on specific known beaches. The strengths and weaknesses of the model have been assessed in terms of data deficiencies. The type and nature of the data which are most useful to, and which need to be collected for, spill planning and spill monitoring were identified. The model shows that the important factors directing the fate of oil on coarse sediment beaches are porosity and permeability, determined by grain size and oil properties (composition, viscosity, etc.). The natural rate of removal of oil, modeled as a first-order (exponential) removal, is dependent on the stage of the spill process and on wave energy

  1. Stochastic Modeling and Performance Analysis of Multimedia SoCs

    DEFF Research Database (Denmark)

    Raman, Balaji; Nouri, Ayoub; Gangadharan, Deepak

    2013-01-01

    solutions where each modeling technique has both the above mentioned characteristics. We present a probabilistic analytical framework and a statistical model checking approach to design system-on-chips for low-cost multimedia systems. We apply the modeling techniques to size the output buffer in a video......Reliability and flexibility are among the key required features of a framework used to model a system. Existing approaches to design resource-constrained, soft-real time systems either provide guarantees for output quality or account for loss in the system, but not both. We propose two independent...... decoder. The results shows that, for our stochastic design metric, the analytical framework upper bounds (and relatively accurate) compare to the statistical model checking technique. Also, we observed significant reduction in resource usage (such as output buffer size) with tolerable loss in output...

  2. International business and the eclectic paradigm

    DEFF Research Database (Denmark)

    The eclectic paradigm has become the dominant theoretical basis in the study of international business, multinational corporations and internationalization since 1980. However, developments such as economic globalization and the subsequent growth of global and alliance capitalism have fundamentally......, finance, evolutionary economics, resource-based theory or strategic management? Can it be utilized to explain new developments in international business and economics? Do these require new ideas and concepts to be integrated within the eclectic paradigm? What are the new challenges to which international...

  3. International Orders in the Early Modern World

    DEFF Research Database (Denmark)

    This book challenges the Eurocentric foundations of modern International Relations scholarship. Its primary empirical focus is the early modern era, when European primacy had yet to develop in many parts of the globe. It presents a series of regional case studies from experts on East Asia, the Mi...... and scholars of international relations, international relations theory, international history, early modern history and sociology.......This book challenges the Eurocentric foundations of modern International Relations scholarship. Its primary empirical focus is the early modern era, when European primacy had yet to develop in many parts of the globe. It presents a series of regional case studies from experts on East Asia......, the Middle East, Africa and Latin America, and Russia to explore patterns of cross-cultural exchange and civilizational encounters. The authors analyze a series of regional international orders which were primarily defined by local interests, agendas and institutions, with European interlopers often playing...

  4. Development of control system for multi-converter High voltage Power supply using programmable SoC

    Science.gov (United States)

    Dave, Rasesh; Dharangutti, Jagruti; Singh, N. P.; Thakar, Aruna; Dhola, Hitesh; Gajjar, Sandip; Parmar, Darshan; Zaveri, Tanish; Baruah, Ujjwal

    2017-04-01

    Multi-converter based High Voltage Power Supplies (HVPSs) find application in multi-megawatt accelerators, RF systems. Control system for HVPS must be a combination of superior parallel processing, real time performance, fast computation and versatile connectivity. The hardware platform is expected to be robust, easily scalable for future developments with minimal overheads. This paper describes development of control system on Zynq All Programmable SoC (System on Chip) for HVPS. Typical HVPS control mechanism involves communication, generation of precise control signals/pulses for few hundred numbers of chopper and closed loop control in microsecond range for regulated output. Such kind of requirements can be met with Zynq All Programmable SoC, which is a combination of Dual core ARM Cortex A-9 Processing System (PS) and Xilinx 7 series FPGA based Programmable Logic (PL). Deterministic functions of power supply control system such as generation of control signals with precise inter-channel delay of nanosecond range and communication with individual chopper at 100kbps can be implemented on PL. PS should implement corrective tasks based on field feedback received from individual chopper, user interface and OS management that allows to take full advantage of system capabilities. PS and PL are connected with on-chip AXI-4 interface with low latency and higher bandwidth through 9 AXI ports. Typically PS boots first, this ensures secure booting and prevents external environment from tampering PL.

  5. Development of control system for multi-converter high voltage power supply using programmable SoC

    International Nuclear Information System (INIS)

    Dave, Rasesh; Singh, N.P.; Thakar, Aruna; Dhola, Hitesh; Gajjar, Sandip; Parmar, Darshan Kumar; Baruah, Ujjwal Kumar; Dharangutti, Jagruti; Zaveri, Tanish

    2015-01-01

    Multi-converter based High Voltage Power Supplies (HVPSs) find application in multi-megawatt accelerators, RF systems. Control system for HVPS must be a combination of superior parallel processing, real time performance, fast computation and versatile connectivity. The hardware platform is expected to be robust, easily scalable for future developments without any cost overhead. Typical HVPS control mechanism involves communication, generation of precise control signals/pulses for few hundred Nos of chopper and closed loop control in microsecond range for regulated output. Such kind of requirements can be met with Zynq All Programmable SoC, which is a combination of Dual core ARM Cortex A-9 Processing System (PS) and Xilinx 7 series FPGA based Programmable Logic (PL). Deterministic functions of power supply control system such as generation of control signals with precise inter-channel delay of nanosecond range and communication with individual chopper at 100kbps can be implemented on PL. PS should implement corrective tasks based on field feedback received from individual chopper, user interface and OS management that allows to take full advantage of system capabilities. PS and PL are connected with on-chip AXI-4 interface with low latency and higher bandwidth through 9 AXI ports. Typically PS boots first, this ensures secure booting and prevents external environment from tampering PL. This paper describes development of control system on Zynq All Programmable SoC for HVPS. (author)

  6. Surface Observation Climatic Summaries (SOCS) for Volk Field ANGB, Wisconsin.

    Science.gov (United States)

    1989-05-01

    LIMIT(S), EITHER SEPARATELY OR IN ANY C󈧒RINATI"Pl. TOTALS PROGRESS FROM RIGHT Tl LEFT AND PRUM BOTTOM1 T2 TOP. TOJ OETER Iljt CEILINS ALINE, REFER TO...THE cATREME7 RIGTHAND CO]LUMN (ZER? VISI3ILITY). TO DETERM’INE VISIBI1LITY ALINE, R’EFER TO THE BOTTOM ROW (ZEkO CEILINGS). OETER 𔃾INE THE P9F THAT

  7. Realistically Rendering SoC Traffic Patterns with Interrupt Awareness

    DEFF Research Database (Denmark)

    Angiolini, Frederico; Mahadevan, Sharkar; Madsen, Jan

    2005-01-01

    to generate realistic test traffic. This paper presents a selection of applications using interrupt-based synchronization; a reference methodology to split such applications in execution subflows and to adjust the overall execution stream based upon hardware events; a reactive simulation device capable...... of correctly replicating such software behaviours in the MPSoC design phase. Additionally, we validate the proposed concept by showing cycle-accurate reproduction of a previously traced application flow....

  8. Enterprise interoperability ontology for SOC applied to logistics

    NARCIS (Netherlands)

    Hofman, W.J.

    2010-01-01

    The Service Oriented Architecture (SOA, [1]) can be applied to enterprise integration. It creates an Internet of services for enterprises. Service science [2] defines services in term of value propositions of enterprises to customers. Both service science and the Internet of services require a form

  9. CURRENT FEATURES OF THE INTERNATIONAL FINANCIAL ORGANIZATIONS

    OpenAIRE

    ЯНІКІН, С.В.; ДВНЗ «КНЕУ імені Вадима Гетьмана», кафедра міжнародних фінансів

    2011-01-01

     This article describes a number of ways, which may facilitate the improvement of activities of international financial institutions at the present level of the global financial system development. Particular attention is paid to the problem of international public goods and their delivery by international financial institutions. Further, an approach of financial dedollarisation of IFIs is discussed as one of highly effective mechanisms. In addition, the article raised and examined in detail ...

  10. Measuring the effectiveness of international environmental regimes

    Energy Technology Data Exchange (ETDEWEB)

    Helm, C.; Sprinz, D.F.

    1999-05-01

    While past research has emphasized the importance of international regimes for international governance, systematic assessments of regime effects are missing. This article derives a standardized measurement concept for the effectiveness of international environmental regimes by developing an operational rational choice calculus to evaluate actual policy simultaneously against a non-regime counterfactual and a collective optimum. Subsequently, the empirical feasibility of the measurement instrument is demonstrated by way of two international treaties regulating transboundary air pollution in Europe. The results demonstrate that the regimes indeed show positive effects - but fall substantially short of the collective optima. (orig.)

  11. Bull.Chem.Soc.Ethiop.,4(1)

    African Journals Online (AJOL)

    axial coordination of halides stabilizes the copper(III) state of copper macrocyclic complexes. ... employed and tetraethylammonium perchlorate, or reagent grade acids were used as supporting electrolytes. RESULTS AND .... Summary of kinetic parameters for acid dependent Fe(phen)3+ oxidetions of b-diimine complexes.

  12. International market research at the Mayo Clinic.

    Science.gov (United States)

    Hathaway, M; Seltman, K

    2001-01-01

    Mayo Clinic has a long international history and has been providing care to international patients since its inception. Despite its history and reputation, however, the marketing staff continues to monitor the international market to gauge the level of awareness, reputation, and attractiveness of Mayo Clinic around the world. Here's a look at how one institution has used word-of-mouth marketing to maintain its global reputation.

  13. The challenges of introducing internal social media

    DEFF Research Database (Denmark)

    Madsen, Vibeke Thøis

    2017-01-01

    Purpose – The purpose of this paper is to explore the challenges associated with introducing internal social media (ISM) into organizations in order to help them reap the benefits of coworker communication on ISM. Design/methodology/approach – The paper is based on an exploratory study in ten...... facilitators and sense-givers. Keywords Organizational communication, Internal communication, Coworker, Internal social media Paper type Research paper...

  14. LHCb in the International Particle Physics Masterclasses

    CERN Document Server

    Couturier, Ben

    2016-01-01

    The Large Hadron Collider Beauty (LHCb) Experiment joined the International Particle Physics Masterclass programme in 2013. The experiment proposed the measurement of the D0 meson lifetime, using real data gathered at the Large Hadron Collider in 2012. We describe the exercise as well as the lessons learned during this first participation in the International Masterclass programme.

  15. The importance of international cooperation

    CSIR Research Space (South Africa)

    NASR, Jean-Marc

    2017-01-01

    Full Text Available Limited R&D budgets Marginal growth Increased R&T with international institutes & academia Intra-African market Center of gravity has changed Global supply sourcing Local Servicing of products Airbus Global Footprint May 2017 Airbus... 31% Europe 69% Non-Europe Other countries 11,575 (9%) Non-European Workforce 20% (in 2020) PHILOSOPHY OF INTERNATIONALIZATION Airbus Footprint in Africa May 2017 Airbus Corporate Presentation 4 Addis Ababa Nairobi Abuja Algiers Cairo...

  16. The International harmonisation process of Accounting Standards

    OpenAIRE

    Fritz, Susanne; Lämmle, Christina

    2003-01-01

    Background: Growth in international trade and capital flows has triggered a rising economic integration. Because of these developments there has been an international homogenising effect upon many customs, practices and institutions. In business life it led among other things to a desire to harmonise Accounting Standards among countries. Purpose: Our purpose is to answer the question: What is the international harmonisation process of Accounting Standards, what is its status quo and how impo...

  17. The second international workshop on enterprise security

    OpenAIRE

    Chang, V; Ramachandran, M; Yen, NN; Walters, RJ; Wills, G

    2016-01-01

    Welcome to our second international workshop on Enterprise Security as part of CloudCom 2015, Vancouver, Canada, November 30-December 3, 2015. The first international workshop held in Singapore has been a major success since then we have achieved greater team activities, research, and international collaborations as the major and significant outcome of our first workshop on this topic. Enterprise Security involves all business, products, governments, organization, and their contractors. This ...

  18. 28 JURISDICTION OF THE INTERNATIONAL CRIMINAL COURT

    African Journals Online (AJOL)

    Fr. Ikenga

    legal responses by concerned governments or the international community to international crimes. As a result of hard negotiations, it was agreed that the Rome Statute prohibits the ... the ICC may exercise its jurisdiction when the crime is committed on the ..... Human Rights Committee indicates that non bis in idem has only.

  19. Adjustment of the Internal Tax Scale

    CERN Multimedia

    2013-01-01

    In application of Article R V 2.03 of the Staff Regulations, the internal tax scale has been adjusted with effect on 1 January 2012. The new scale may be consulted via the CERN Admin e-guide.  The notification of internal annual tax certificate for the financial year 2012 takes into account this adjustment. HR Department (Tel. 73907)

  20. Internal and External Resources as Determinants of Health and Quality of Life.

    Directory of Open Access Journals (Sweden)

    Elfriede Greimel

    Full Text Available The salutogenic model has been established as a health promoting resource that is related to a strong sense of coherence (SOC, positive subjective health and quality of life (QoL. The aim of the study was to compare internal and external resources, life style factors, perceived health and QoL in Japan and Austria and to determine associations among these factors.A survey was conducted in a Japanese (N = 460 and an Austrian (N = 421 student sample using the following self-report health questionnaires: Sense of Coherence Scale (SOC-13, Social and Gender Role Scale, Multidimensional Scale of Perceived Social Support (MSPSS, Dutch Eating Behaviour Questionnaire (DEBQ, SF-12 Health Survey, and the Cross-cultural Health Survey. Analyses of data showed that age (ß -0.12, and stress (ß -0.21 were negatively related and SOC (ß 0.47, family support are (ß -0.35 positively related to mental QoL. Significant predictors for emotional strain, were female gender (ß -0.24, older age (ß-0.14, lower SOC (ß 0.28, less traditional gender and social role patterns (ß 0.10, more restrained eating (ß -0.20, more alcohol intake (ß -0.16, and more stress (ß -0.25 explaining 42% of the variance in Austrian students. In Japan stress (ß -0.38 was negatively related and SOC (ß 0.37 positively related to mental QoL. Older age (ß -0.20, lower SOC (ß 0.29 and more stress (ß -0.33 were identified as significant predictors explaining 35% of the variance in Japanese students.SOC and stress are strongly associated with QoL and perceived health in Austria as well as in Japan. SOC seems to be a crucial predictor for stress, and emotional health independent of the cultural context. A major challenge of cross-cultural research is to understand perceived health and QoL and the extent in which it is individually, socially, or culturally determined.

  1. Internal and External Resources as Determinants of Health and Quality of Life.

    Science.gov (United States)

    Greimel, Elfriede; Kato, Yoshiko; Müller-Gartner, Maria; Salchinger, Beate; Roth, Roswith; Freidl, Wolfgang

    2016-01-01

    The salutogenic model has been established as a health promoting resource that is related to a strong sense of coherence (SOC), positive subjective health and quality of life (QoL). The aim of the study was to compare internal and external resources, life style factors, perceived health and QoL in Japan and Austria and to determine associations among these factors. A survey was conducted in a Japanese (N = 460) and an Austrian (N = 421) student sample using the following self-report health questionnaires: Sense of Coherence Scale (SOC-13), Social and Gender Role Scale, Multidimensional Scale of Perceived Social Support (MSPSS), Dutch Eating Behaviour Questionnaire (DEBQ), SF-12 Health Survey, and the Cross-cultural Health Survey. Analyses of data showed that age (ß -0.12), and stress (ß -0.21) were negatively related and SOC (ß 0.47), family support are (ß -0.35) positively related to mental QoL. Significant predictors for emotional strain, were female gender (ß -0.24), older age (ß-0.14), lower SOC (ß 0.28), less traditional gender and social role patterns (ß 0.10), more restrained eating (ß -0.20), more alcohol intake (ß -0.16), and more stress (ß -0.25) explaining 42% of the variance in Austrian students. In Japan stress (ß -0.38) was negatively related and SOC (ß 0.37) positively related to mental QoL. Older age (ß -0.20), lower SOC (ß 0.29) and more stress (ß -0.33) were identified as significant predictors explaining 35% of the variance in Japanese students. SOC and stress are strongly associated with QoL and perceived health in Austria as well as in Japan. SOC seems to be a crucial predictor for stress, and emotional health independent of the cultural context. A major challenge of cross-cultural research is to understand perceived health and QoL and the extent in which it is individually, socially, or culturally determined.

  2. The empirical turn in international legal scholarship

    Directory of Open Access Journals (Sweden)

    Gregory Shaffer

    2015-07-01

    Full Text Available This article presents and assesses a new wave of em- pirical research on international law. Recent scholar- ship has moved away from theoretical debates over whether international law “matters,” and focuses in- stead on exploring the conditions under which inter- national law is created and produces effects. As this empirical research program has matured, it has al- lowed for new, midlevel theorizing that we call “conditional international law theory”. 

  3. The Political Economy of International Treaties

    NARCIS (Netherlands)

    Merkouris, Panagiotis; Fabbricotti, Alberta

    2016-01-01

    The book, which the present Chapter is a part of, is a ‘call to arms’ for a more systematic and systemic PE- (political economy) and IPE-oriented (international political economy) study of PIL (public international law). The present Chapter tackles the task of demonstrating the need for a PE and IPE

  4. Closing the Wage Gap. An International Perspective.

    Science.gov (United States)

    National Committee on Pay Equity, Washington, DC.

    This document comprises a report on international progress to close the "wage gap", the differential between the earnings of women and men. Information was gathered on pay equity activities from a survey of government agencies, trade unions, women's organizations, and international bodies. Almost all of the jurisdictions surveyed have…

  5. Nuclear insurance in the future Internal Market

    International Nuclear Information System (INIS)

    Mueller-Stein, J.

    1991-01-01

    Summarizing, it is prognosticated that nuclear insurance practice will not drastically change on account of the Internal Market. This assumption is based on the unanimous estimation of the nuclear energy risk by the international insurance industry, as is documented by their traditional good cooperation in pools. (orig.) [de

  6. The Intern Studio: A Pilot Study.

    Science.gov (United States)

    Wix, Linney

    1995-01-01

    Describes and discusses the Intern Studio Project, which consists of the provision of regular open studio time for art therapy interns in a state university graduate program. Psychological and artistic bases for the open studio approach are discussed, and include the relational approach, Hillman's essentialist paradigm, and series and context…

  7. The faltering legitimacy of international tax law

    NARCIS (Netherlands)

    Peters, C.A.T.

    2013-01-01

    International taxation has taken a central role in the ongoing political and economic crisis. There is a growing consensus in society that there is a need to change the current rules and norms of international taxation, since the changes in society are not properly reflected in the body of law

  8. The EU as an international security provider

    DEFF Research Database (Denmark)

    Rodt, Annemarie Peen; Wolff, Stefan; Whitman, Richard

    2015-01-01

    This contribution develops a framework of analysis that covers the actors involved in the policy making process of international security provision, the dynamics of this process itself, its outcomes (concrete strategies and policies) and their impact. Our efforts to establish such a framework...... of analysis, which could serve as the foundation for a mid-range theory of the EU as an international security provider, will examine the relevance of, and apply, existing theories of international relations/international security and foreign policy analysis to the specific case of the EU. The framework...... that will emerge from this analysis will then be tested and applied empirically in the following contributions that focus on how particular policies are formulated and implemented, and that analyse, in single and comparative case studies, the impact and effectiveness of the EU as an international security provider....

  9. Creating the optimized international marketing mix

    Directory of Open Access Journals (Sweden)

    Grubor Aleksandar

    2005-01-01

    Full Text Available In the international practice of Serbian companies still dominant approach is based on traditional foreign trade approach, which in the significant dimension ballast effective inclusion of domestic companies in the contemporary business. Such practice is a result of the modality of international trading evolved and stimulated recently including long lasting period of self managing socialism-business as well international orientation in trading was originated by the state support, which procured in the edification of so-called national corporations as a chief exporter. Long-time existing of that modality of the international trading procured in the shrinking and limitation possibilities for comprehensive development of the international orientation of domestic i.e local companies, which is an argument of objectively difficult international position of Serbian firms in the moment. Paper discuss different issues including assessment that incoming presence of regional or international investors on the domestic market will proffer possibilities for enhancement a domestic management and marketing know - how among others. So, this is a way how local management circles could make substantial progress in creating the optimized international marketing mix within domestic companies following on-going business experience.

  10. Bilateral duplication of the internal auditory canal

    International Nuclear Information System (INIS)

    Weon, Young Cheol; Kim, Jae Hyoung; Choi, Sung Kyu; Koo, Ja-Won

    2007-01-01

    Duplication of the internal auditory canal is an extremely rare temporal bone anomaly that is believed to result from aplasia or hypoplasia of the vestibulocochlear nerve. We report bilateral duplication of the internal auditory canal in a 28-month-old boy with developmental delay and sensorineural hearing loss. (orig.)

  11. The political economy of international accounting standards

    NARCIS (Netherlands)

    Perry, J.; Nolke, A.

    2006-01-01

    On 1 January 2005, all stock exchange listed companies in the European Union (EU) began using International Financial Reporting Standards (IFRS) written by the International Accounting Standards Board (IASB). This article argues that the IASB's introduction of fair value accounting reflects and

  12. The International Research Experience: Executive MBA Distinctiveness.

    Science.gov (United States)

    Ambrose, David M.; Pol, Louis G.

    1995-01-01

    The University of Nebraska's Executive Master's in Business Administration (MBA) program has integrated international research activities into the curriculum. The university contracted with domestic corporations to conduct studies on prospects for international business. Research assignments include assessment of competitors, economic evaluations,…

  13. Characteristics of the nurse manager's recognition behavior and its relation to sense of coherence of staff nurses in Japan.

    Science.gov (United States)

    Miyata, Chiharu; Arai, Hidenori; Suga, Sawako

    2015-01-01

    The recognition behaviors strongly influence the job satisfaction of staff nurses and an extremely important factor for the prevention of burnout and the promotion of retention. Additionally, among internal factors that may affect worker's mental health, a sense of coherence (SOC) is an important concept from the view of the salutogenic theory and stress recognition style. Individual's SOC increases in relation to recognition behavior. However, in Japan, few studies have examined the effect of recognition behaviors on the SOC of staff nurses. The purpose of this study was to investigate how staff nurses perceive recognition behaviors of the nurse manager and to determine the relationship between recognition behaviors and the staff nurses' SOC. This quantitative, cross-sectional study involved 10 hospitals in Japan. A total of 1425 nurses completed the questionnaire. As a result, the perceptions of nurse manager's recognition behaviors by staff nurses were evaluated by presentation and report, individual value and the transfer of responsibility, and professional development. The median score of staff nurse SOC-13 was 50 (IQR; 45-55). Significant differences in SOC scores were found in marital status, age, years of experience, and mental and physical health condition. In conclusion, recognition behaviors by the nurse manager can improve staff nurse's SOC and effectively support the mental health of the staff nurse.

  14. The US DOE EM international program

    Energy Technology Data Exchange (ETDEWEB)

    Elmetti, Rosa R.; Han, Ana M. [U.S. Department of Energy, Washington, D.C. (United States); Roach, Jay A. [Nexergy Technical, LLC., Falls Church, Virginia (United States)

    2013-07-01

    The U.S. Department of Energy (DOE) Office of Environmental Management (EM) conducts international collaboration activities in support of U.S. policies and objectives regarding the accelerated risk reduction and remediation of environmental legacy of the nations' nuclear weapons program and government sponsored nuclear energy research. The EM International Program supported out of the EM Office of the Associate Principal Deputy Assistant Secretary pursues collaborations with foreign government organizations, educational institutions and private industry to assist in identifying technologies and promote international collaborations that leverage resources and link international experience and expertise. In fiscal year (FY) 2012, the International Program awarded eight international collaborative projects for work scope spanning waste processing, groundwater and soil remediation, deactivation and decommissioning (D and D) and nuclear materials disposition initiatives to seven foreign organizations. Additionally, the International Program's scope and collaboration opportunities were expanded to include technical as well as non-technical areas. This paper will present an overview of the on-going tasks awarded in FY 2012 and an update of upcoming international activities and opportunities for expansion into the remainder of FY 2013 and beyond. (authors)

  15. The foundations of the international legal order

    NARCIS (Netherlands)

    d' Aspremont, J.

    2009-01-01

    The multifaceted character of globalization constantly confuses our understanding of the theoretical foundations of the global legal order. One of the most common answers to the complexity of any such undertaking has been provided by international constitutionalists, who have advocated a conception

  16. Internality and Achievement in the Intermediate Grades.

    Science.gov (United States)

    Creek, Roy J.; And Others

    Locus of control is a construct that reflects an individual's perception of control over his or her own destiny. The thesis is that people adopt either an internal or an external orientation. Internally oriented persons consider success the result of ability and effort. Externally oriented individuals attribute success to luck, fate, or powerful…

  17. International Education and the International Baccalaureate Diploma Programme: A View from the Perspective of Postcolonial Thought

    Science.gov (United States)

    Hughes, Conrad

    2009-01-01

    This article aims to look at the concepts of internationalism and international education through the lens of postcolonial theory, arguing that the fundamental aims of international education are obstructed as it remains a concept locked in the idea of the nation state that has not evolved with the ideas of major postcolonial theorists. However,…

  18. Symposium 'The politics of international recognition'

    NARCIS (Netherlands)

    Agne, Hans; Bartelson, Jens; Erman, Eva; Lindemann, Thomas; Herborth, Benjamin; Kessler, Oliver; Chwaszcza, Christine; Fabry, Mikulas; Krasner, Stephen D.

    Recognition plays a multifaceted role in international theory. In rarely communicating literatures, the term is invoked to explain creation of new states and international structures; policy choices by state and non-state actors; and normative justifiability, or lack thereof, of foreign and

  19. The case of Kosovo and international law

    Czech Academy of Sciences Publication Activity Database

    Šturma, Pavel

    2010-01-01

    Roč. 29, č. 2009 (2010), s. 51-65 ISSN 0554-498X Institutional research plan: CEZ:AV0Z70680506 Keywords : public international law * independence of the Kosovo * International Court of Justice Subject RIV: AG - Legal Sciences

  20. Networking our science to characterize the state, vulnerabilities, and management opportunities of soil organic matter

    Science.gov (United States)

    Harden, Jennifer W.; Hugelius, Gustaf; Ahlström, Anders; Blankinship, Joseph C.; Bond-Lamberty, Ben; Lawrence, Corey; Loisel, Julie; Malhotra, Avni; Jackson, Robert B.; Ogle, Stephen M.; Phillips, Claire; Ryals, Rebecca; Todd-Brown, Katherine; Vargas, Rodrigo; Vergara, Sintana E.; Cotrufo, M. Francesca; Keiluweit, Marco; Heckman, Katherine; Crow, Susan E.; Silver, Whendee L.; DeLonge, Marcia; Nave, Lucas E.

    2018-01-01

    Soil organic matter (SOM) supports the Earth's ability to sustain terrestrial ecosystems, provide food and fiber, and retains the largest pool of actively cycling carbon. Over 75% of the soil organic carbon (SOC) in the top meter of soil is directly affected by human land use. Large land areas have lost SOC as a result of land use practices, yet there are compensatory opportunities to enhance productivity and SOC storage in degraded lands through improved management practices. Large areas with and without intentional management are also being subjected to rapid changes in climate, making many SOC stocks vulnerable to losses by decomposition or disturbance. In order to quantify potential SOC losses or sequestration at field, regional, and global scales, measurements for detecting changes in SOC are needed. Such measurements and soil-management best practices should be based on well established and emerging scientific understanding of processes of C stabilization and destabilization over various timescales, soil types, and spatial scales. As newly engaged members of the International Soil Carbon Network, we have identified gaps in data, modeling, and communication that underscore the need for an open, shared network to frame and guide the study of SOM and SOC and their management for sustained production and climate regulation.

  1. Egr2 enhances insulin resistance via JAK2/STAT3/SOCS-1 pathway in HepG2 cells treated with palmitate.

    Science.gov (United States)

    Lu, Lin; Ye, Xinhua; Yao, Qing; Lu, Aijiao; Zhao, Zhen; Ding, Yang; Meng, Chuchen; Yu, Wenlong; Du, Yunfeng; Cheng, JinLuo

    2018-05-01

    Insulin resistance is generally responsible for the pathogenesis of type 2 diabetes mellitus (T2DM). Early growth response proteins-2 (Egr2) has been reported to be able to increase the expression of the suppressors of cytokine signaling-1 (SOCS-1), and impair insulin signaling pathway through suppression of insulin receptor substrates (IRS), including IRS-1 and IRS-2. However, whether Egr2 is directly involved in the development of insulin resistance, and how its potential contributions to insulin resistance still remain unknown. Here, our present investigation found that the expression levels of Egr2 were up-regulated when insulin resistance occurs, and knockdown of Egr2 abolished the effect of insulin resistance in HepG2 cells induced with palmitate (PA). Importantly, inhibition of Egr2 decreased the expression of SOCS-1 as well as reduced phosphorylation of JAK2 and STAT3. And, our data indicated that silencing of Egr2 accelerated hepatic glucose uptake and reversed the impaired lipid metabolism upon insulin resistance. In summary, the present study confirms that Egr2 could deteriorate insulin resistance via the pathway of JAK2/STAT3/SOCS-1 and may shed light on resolving insulin resistance and further the pathogenesis of T2DM. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. CTBT and the international technical cooperation

    International Nuclear Information System (INIS)

    Zhang Lixing

    1999-01-01

    Having in mind the basic aim of the CTBTO this presentation covers the fields of international co-operation as one of the most important and the cooperation of China and some International research and development institutions concerning the related subjects. One of the most important among international organizations being the IAEA, detailed list of general circumstances in the Chinese cooperation with IAEA is presented. It covers nuclear power plants construction and operation, safety of nuclear facilities, nuclear fuel cycle, radiation protection and waste management, industrial application, agricultural application, human health, fundamental research and information dissemination

  3. REVOLUTIONS AND INTERNATIONAL RELATIONS: THE AFRICAN CASE

    Directory of Open Access Journals (Sweden)

    Paulo Fagundes Visentini

    2016-05-01

    Full Text Available Analysis of the impact of revolutions in the International Relations and the World System as constitutive and renewed elements. Criticizes the stance of theories that consider it a domestic phenomenon that causes a systemic disturbance, focusing in the case of the African Revolutions in the 1970s. Explores the international dimension they possess, considering their impact regarding the end of the Cold War, even though it happened in the periphery of the world.

  4. PHILIPPINE COCONUT INDUSTRY AND THE INTERNATIONAL TRADE

    OpenAIRE

    Oniki, Shunji

    1992-01-01

    This study explores effects of Philippines' coconut policies on the performance in the international market. Analysis of the coconut sector found that the Philippine government successfully changed the structure of the coconut industry during the 1970's using a fund collected as coconut levies. Since the Philippines dominated the international trade market of coconut products, it could exercise dominant market power in the world trade, by integrating the domestic sector. However, the industri...

  5. Expanding the role of internal facility assessments

    Energy Technology Data Exchange (ETDEWEB)

    Kolpa, R.L.; Levenson, J.B. [Argonne National Lab., IL (United States); Weaver, M.A. [Headquarters Air Force Materiel Command, Wright-Patterson AFB, OH (United States)

    1996-05-01

    The US Air Force (USAF) Environmental Compliance Assessment and Management Program (ECAMP) is an effective and comprehensive system to evaluate environmental compliance at individual USAF installations. The ECAMP assessment is typically performed by a team of experts from the installation`s Major Command (MAJCOM) Headquarters, and is often augmented with technical contractor support. As directed by Air Force policy, an external ECAMP assessment is required at a minimum of every three years for each installation. In the intervening years, each installation is required to perform an internal ECAMP assessment, with its own personnel and resources. Even though team composition differs, the internal and external ECAMP assessments are likely to be very similar in scope, objectives, and deliverables. For over nine years, Argonne National Laboratory (ANL) has supported several Air Force MAJCOMs in performing their external ECAMP assessments. More recently, ANL has also had the opportunity to provide technical support and training at individual installations during their preparation and conduct of internal ECAMP assessments. From that experience, the authors have learned that the quality and value of the internal assessment is enhanced by making it a vehicle for training, planning, and interaction among organizations. Various strategies and techniques have been successfully employed to derive maximum benefit and insight from the internal assessment process. Experiences that involve expanding the scope and objectives of internal assessments to meet specific goals are presented. The expansion of scope and objectives include preassessment training, planning, and evaluator interactions as part of the overall internal assessment process.

  6. Semivolatile Organic Compounds (SOCs) in Fine Particulate Matter (PM2.5) during Clear, Fog, and Haze Episodes in Winter in Beijing, China.

    Science.gov (United States)

    Wang, Ting; Tian, Mi; Ding, Nan; Yan, Xiao; Chen, She-Jun; Mo, Yang-Zhi; Yang, Wei-Qiang; Bi, Xin-Hui; Wang, Xin-Ming; Mai, Bi-Xian

    2018-05-01

    Few efforts have been made to elucidate the influence of weather conditions on the fate of semivolatile organic compounds (SOCs). Here, daily fine particulate matter (PM 2.5 ) during clear, haze, and fog episodes collected in the winter in Beijing, China was analyzed for polycyclic aromatic hydrocarbons (PAHs), brominated flame retardants (BFRs), and organophosphate flame retardants (OPFRs). The total concentrations of PAHs, OPFRs, and BFRs had medians of 45.1 ng/m 3 and 1347 and 46.7 pg/m 3 , respectively. The temporal pattern for PAH concentrations was largely dependent on coal combustion for residential heating. OPFR compositions that change during colder period were related to enhanced indoor emissions due to heating. The mean concentrations of SOCs during haze and fog days were 2-10 times higher than those during clear days. We found that BFRs with lower octanol and air partition coefficients tended to increase during haze and fog episodes, be removed from PM 2.5 during clear episodes, or both. For PAHs and OPFRs, pollutants that are more recalcitrant to degradation were prone to accumulate during haze and fog days. The potential source contribution function (PSCF) model indicated that southern and eastern cities were major source regions of SOCs at this site.

  7. The extension of the international trade

    International Nuclear Information System (INIS)

    Buch, Tomas

    1998-01-01

    INVAP, a company pertaining to the Rio Negro province and controlled by the National Atomic Energy Commission (CNEA), has been instrumental for the international expansion of the Argentine nuclear trade, including the provision of Argentine research reactors to Algeria and Egypt. The history of the negotiations carried out with about twenty countries is shortly summarized and the scope of the supply of the major contracts is described

  8. A 6.45 μW Self-Powered SoC With Integrated Energy-Harvesting Power Management and ULP Asymmetric Radios for Portable Biomedical Systems.

    Science.gov (United States)

    Roy, Abhishek; Klinefelter, Alicia; Yahya, Farah B; Chen, Xing; Gonzalez-Guerrero, Luisa Patricia; Lukas, Christopher J; Kamakshi, Divya Akella; Boley, James; Craig, Kyle; Faisal, Muhammad; Oh, Seunghyun; Roberts, Nathan E; Shakhsheer, Yousef; Shrivastava, Aatmesh; Vasudevan, Dilip P; Wentzloff, David D; Calhoun, Benton H

    2015-12-01

    This paper presents a batteryless system-on-chip (SoC) that operates off energy harvested from indoor solar cells and/or thermoelectric generators (TEGs) on the body. Fabricated in a commercial 0.13 μW process, this SoC sensing platform consists of an integrated energy harvesting and power management unit (EH-PMU) with maximum power point tracking, multiple sensing modalities, programmable core and a low power microcontroller with several hardware accelerators to enable energy-efficient digital signal processing, ultra-low-power (ULP) asymmetric radios for wireless transmission, and a 100 nW wake-up radio. The EH-PMU achieves a peak end-to-end efficiency of 75% delivering power to a 100 μA load. In an example motion detection application, the SoC reads data from an accelerometer through SPI, processes it, and sends it over the radio. The SPI and digital processing consume only 2.27 μW, while the integrated radio consumes 4.18 μW when transmitting at 187.5 kbps for a total of 6.45 μW.

  9. Black swans, power laws, and dragon-kings: Earthquakes, volcanic eruptions, landslides, wildfires, floods, and SOC models

    Science.gov (United States)

    Sachs, M. K.; Yoder, M. R.; Turcotte, D. L.; Rundle, J. B.; Malamud, B. D.

    2012-05-01

    Extreme events that change global society have been characterized as black swans. The frequency-size distributions of many natural phenomena are often well approximated by power-law (fractal) distributions. An important question is whether the probability of extreme events can be estimated by extrapolating the power-law distributions. Events that exceed these extrapolations have been characterized as dragon-kings. In this paper we consider extreme events for earthquakes, volcanic eruptions, wildfires, landslides and floods. We also consider the extreme event behavior of three models that exhibit self-organized criticality (SOC): the slider-block, forest-fire, and sand-pile models. Since extrapolations using power-laws are widely used in probabilistic hazard assessment, the occurrence of dragon-king events have important practical implications.

  10. Sticker-type ECG/PPG concurrent monitoring system hybrid integration of CMOS SoC and organic sensor device.

    Science.gov (United States)

    Yongsu Lee; Hyeonwoo Lee; Seunghyup Yoo; Hoi-Jun Yoo

    2016-08-01

    The sticker-type sensor system is proposed targeting ECG/PPG concurrent monitoring for cardiovascular diseases. The stickers are composed of two types: Hub and Sensor-node (SN) sticker. Low-power CMOS SoC for measuring ECG and PPG signal is hybrid integrated with organic light emitting diodes (OLEDs) and organic photo detector (OPD). The sticker has only 2g weight and only consumes 141μW. The optical calibration loop is adopted for maintaining SNR of PPG signal higher than 30dB. The pulse arrival time (PAT) and SpO2 value can be extracted from various body parts and verified comparing with the reference device from 20 people in-vivo experiments.

  11. Kosovo: The Quest for Lasting Internal Security

    National Research Council Canada - National Science Library

    Sullivan, Dennis

    2001-01-01

    .... Given the legacy of violence in the region, it is not surprising that the situation in Kosovo is still far from settled and will most likely require long-term engagement from the international community...

  12. On the theory of internal kink oscillations

    International Nuclear Information System (INIS)

    Breizman, B.N.; Candy, J.; Berk, H.L.

    1997-12-01

    In this paper the authors derive a time evolution equation for internal kink oscillations which is valid for both stable and unstable plasma regimes, and incorporates the nonlinear response of an energetic particle population. A linear analysis reveals a parallel between (i) the time evolution of the spatial derivative of the internal kink radial displacement and (ii) the time evolution of the perturbed particle distribution function in the field of an electrostatic wave (Landau problem). They show that diamagnetic drift effects make the asymptotic decay of internal kink perturbations in a stable plasma algebraic rather than exponential. However, under certain conditions the stable root of the dispersion relation can dominate the response of the on-axis displacement for a significant period of time. The form of the evolution equation naturally allows one to include a nonlinear, fully toroidal treatment of energetic particles into the theory of internal kink oscillations

  13. An application of on-line battery monitoring to the Vulcano PV plant

    Energy Technology Data Exchange (ETDEWEB)

    Buonarota, A.; Menga, P.; Ostano, P.; Scarioni, V.

    1988-05-01

    The reliable knowledge of the state-of-charge (SOC) of the battery of a photovoltaic (PV) plant can contribute to improve system management. Unfortunately, the technologies currently adopted to determine the battery SOC are not fully satisfactory. The experience obtained by ENEL (Italian Electricity Board) on traction lead-acid batteries, operating under cyclic conditions, led to the formulation of a simple model capable of describing the relationships among the operating conditions (profile of current, temperature, etc.) and the internal SOC of the battery. This model was extended to the stationary accumulators to the Vulcano PV plant of ENEL, and checked by means of laboratory tests at the CESI (Italy) laboratories. Relevant to this work, an automatic system for the on-line evaluation of the SOC of the battery has recently been set up and installed at Vulcano. This paper presents the basis of the methodology, the layout of the system, and the preliminary results.

  14. The International Arctic Seas Assessment Project

    International Nuclear Information System (INIS)

    Linsley, G.S.; Sjoeblom, K.L.

    1994-01-01

    The International Arctic Seas Assessment Project (IASAP) was initiated in 1993 to address widespread concern over the possible health and environmental impacts associated with the radioactive waste dumped into the shallow waters of the Arctic Seas. This article discusses the project with these general topics: A brief history of dumping activities; the international control system; perspectives on arctic Seas dumping; the IASAP aims and implementation; the IASAP work plan and progress. 2 figs

  15. The international nuclear non-proliferation system

    International Nuclear Information System (INIS)

    Simpson, J.; McGrew, T.

    1985-01-01

    This volume focuses upon the issues raised at this Conference, and attempts to address the international diplomatic, political and trading, rather than technical, questions which surround nuclear non-proliferation policies. It does so by bringing together chapters contributed by participants in non-proliferation diplomacy, those with experience in shaping International Atomic Energy Agency and national policies and academic observers of non-proliferation activities and the international nuclear industry. An analysis is provided of past non-proliferation policies and activities and current issues, and an attempt is made to offer ideas for new initiatives which may sustain the non-proliferation system in the future

  16. Changes in the International Wine Market

    OpenAIRE

    Vlahović, Branislav; Puškarić, Anton; Tomašević, Dejan

    2013-01-01

    Knowing international market is a basis for segmentation and making right and timely marketing decisions regarding wine export. In this piece, we have analized the international wine market, and determined changes in international turnover, with largest importers and exporters for the period of 2001 - 2011. The average wine export in the world was 8,4 tons, with a growth tendency of 5,0% per year. Converted in money, the average export amounted to 22 billion US Dollars, which makes wine one o...

  17. The International School Industry: Examining International Schools through an Economic Lens

    Science.gov (United States)

    MacDonald, James

    2006-01-01

    Based upon the results of a quantitative analysis of tuition revenues generated by international schools, it is argued that international schools can be examined in terms of a global multi-billion dollar industry and that business theory can be, and is being, applied in international schools today. This article proposes that international schools…

  18. The international magnetic fusion energy program

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, T.K.

    1988-10-06

    In May of 1988, the long tradition of international cooperation in magnetic fusion energy research culminated in the initiation of design work on the International Thermonuclear Experimental Reactor (ITER). If eventually constructed in the 1990s, ITER would be the world's first magnetic fusion reactor. This paper discusses the background events that led to ITER and the present status of the ITER activity. This paper presents a brief summary of the technical, political, and organizational activities that have led to the creation of the ITER design activity. The ITER activity is now the main focus of international cooperation in magnetic fusion research and one of the largest international cooperative efforts in all of science. 2 refs., 12 figs.

  19. The international magnetic fusion energy program

    International Nuclear Information System (INIS)

    Fowler, T.K.

    1988-01-01

    In May of 1988, the long tradition of international cooperation in magnetic fusion energy research culminated in the initiation of design work on the International Thermonuclear Experimental Reactor (ITER). If eventually constructed in the 1990s, ITER would be the world's first magnetic fusion reactor. This paper discusses the background events that led to ITER and the present status of the ITER activity. This paper presents a brief summary of the technical, political, and organizational activities that have led to the creation of the ITER design activity. The ITER activity is now the main focus of international cooperation in magnetic fusion research and one of the largest international cooperative efforts in all of science. 2 refs., 12 figs

  20. The International Editorship of Freshwater Systems

    OpenAIRE

    Karl E. Havens

    2001-01-01

    It is my pleasure to announce that two distinguished internationalscientists have joined the editorship of the FreshwaterSystems domain of TheScientificWorldJOURNAL — Professor BrijGopal of Jawaharlal Nehru University (India) and Dr. Manual Gra柠of the Universityof Coimbra (Portugal). Professor Gopal is the Secretary General of the NationalInstitute of Ecology, Editor of the InternationalJournal of Ecology & Environmental Science,and Chairman of the SIL (International Association of Theoretica...

  1. Novel sampling methods for atmospheric semi-volatile organic compounds (SOCs) in a high altitude alpine environment

    Energy Technology Data Exchange (ETDEWEB)

    Offenthaler, I. [Umweltbundesamt GmbH (Austria); Jakobi, G. [Helmholtz Zentrum Muenchen (German Research Centre for Environmental Health) (Germany); Kaiser, A. [ZAMG-Zentralanstalt fuer Meteorologie und Geo-dynamik (Austria); Kirchner, M. [Helmholtz Zentrum Muenchen (German Research Centre for Environmental Health) (Germany); Kraeuchi, N. [WSL-Swiss Federal Institute for Forest, Snow and Landscape Research (Switzerland); Niedermoser, B. [ZAMG-Zentralanstalt fuer Meteorologie und Geo-dynamik (Austria); Schramm, K.-W. [Helmholtz Zentrum Muenchen (German Research Centre for Environmental Health) (Germany); Sedivy, I. [WSL-Swiss Federal Institute for Forest, Snow and Landscape Research (Switzerland); Staudinger, M. [ZAMG-Zentralanstalt fuer Meteorologie und Geo-dynamik (Austria); Thanner, G.; Weiss, P. [Umweltbundesamt GmbH (Austria); Moche, W., E-mail: wolfgang.moche@umweltbundesamt.a [Umweltbundesamt GmbH (Austria)

    2009-12-15

    High- and low-volume active air samplers as well as bulk deposition samplers were developed to sample atmospheric SOCs under the adverse conditions of a mountain environment. Active sampling employed separate filters for different European source regions. Filters were switched depending on daily trajectory forecasts, whose accuracy was evaluated post hoc. The sampling continued on three alpine summits over five periods of four months. The prevailing trajectories varied stronger between sampling periods than between stations. The sampling equipment (active and bulk deposition) proved dependable for operation in a mountain environment, with idle times being mainly due to non-routine manipulations and connectivity. - Equipment for direction-specific air sampling and bulk deposition sampling in mountains was developed and tested.

  2. The CHIP surveys | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-07-08

    Jul 8, 2011 ... Many of the young scholars relied on data generated by the China Household Income Project (CHIP), a collaboration between Chinese and international economists that has tracked inequality in China for the past 20 years.

  3. RESEARCH ON THE INTERNATIONAL ACCOUNTING HARMONIZATION PROCESS

    Directory of Open Access Journals (Sweden)

    Tatiana Danescu

    2016-12-01

    Full Text Available During the last decades, the need of harmonization of the financial reporting frameworks has become more acute, mostly because the capital markets are not restricted anymore by country borders and capital movement has outlined the phenomenon of globalization and internationalism. A significant step in harmonizing the financial reporting was done in the process of normalization through different sets of rules and principles, recognized and applied in many states are the International Financial Reporting Standards (IFRS. The process of international recognition of these standards continues along with conceptual development which is based on epistemological research on specific markets, industries, economies open to international capital flows. In this context it becomes of interest to identify and understand generally accepted and applied accounting elements which carry forward the accounting harmonization process along with factors and circumstances that create diversity in nationally applied financial reporting frameworks.

  4. Where are the poor in International Economics?

    OpenAIRE

    Luis Carvalho; Aurora A.C. Teixeira

    2011-01-01

    Despite the fact that a very significant proportion of the human population is living with financial difficulties and other constraints typical of poverty, scientific studies in the areas of Economics and especially in International Economics that address the issue of poverty and of poor countries are very few. Using bibliometric techniques, we measured the attention paid by authors from the field of International Economics to poverty and poor countries. To this end, we sorted and analyzed al...

  5. SEIZURE PREDICTION: THE FOURTH INTERNATIONAL WORKSHOP

    Science.gov (United States)

    Zaveri, Hitten P.; Frei, Mark G.; Arthurs, Susan; Osorio, Ivan

    2010-01-01

    The recently convened Fourth International Workshop on Seizure Prediction (IWSP4) brought together a diverse international group of investigators, from academia and industry, including epileptologists, neurosurgeons, neuroscientists, computer scientists, engineers, physicists, and mathematicians who are conducting interdisciplinary research on the prediction and control of seizures. IWSP4 allowed the presentation and discussion of results, an exchange of ideas, an assessment of the status of seizure prediction, control and related fields and the fostering of collaborative projects. PMID:20674508

  6. The International Dermatology Outcome Measures Group

    DEFF Research Database (Denmark)

    Gottlieb, Alice B; Levin, Adriane A; Armstrong, April W

    2015-01-01

    As quality standards are increasingly in demand throughout medicine, dermatology needs to establish outcome measures to quantify the effectiveness of treatments and providers. The International Dermatology Outcome Measures Group was established to address this need. Beginning with psoriasis...

  7. Resolving the International Monetary Fund's Legitimacy Crisis

    DEFF Research Database (Denmark)

    Seabrooke, Leonard

    2006-01-01

    Since the Asian financial crisis of 1997-1998 the International Monetary Fund (the Fund) has been embroiled in an international crisis of legitimacy. Assertions of a crisis are premised on the notions that the Fund's voting system is unfair, and that the Fund enforces homogenous policies onto...... borrowing member states and that loan programs tend to fail. Seen this way, poor institutional and policy design has led to a loss of legitimacy. But institutionalised inequalities or policy failure is not in itself sufficient to constitute an international crisis of legitimacy. This article provides...... a conceptually-driven discussion of the sources of the Fund's international crisis of legitimacy by investigating how its formal "foreground" institutional relations with its member states have become strained, and how informal "background" political and economic relationships are expanding in a way...

  8. The Concept of Law and International Society

    DEFF Research Database (Denmark)

    Schaumburg-Müller, Sten

    Hedley Bull, one of the founders of the School of International Society (English School) relies heavily on H.L.A. Hart in his understanding of law, including international law. The contribution seeks to explore 1) how Bull has creatively made use of Hart's Concept of Law, 2) on which points Hart'......'s theory has short comings, 3) on which additional points Bull's use of the concept of law has short comings, and 4) sketch of ideas how to improve the various short comings.......Hedley Bull, one of the founders of the School of International Society (English School) relies heavily on H.L.A. Hart in his understanding of law, including international law. The contribution seeks to explore 1) how Bull has creatively made use of Hart's Concept of Law, 2) on which points Hart...

  9. The International Context of Educational Research.

    Science.gov (United States)

    Husen, Torsten

    1983-01-01

    Comparative educational research and cross-national studies are described. The author suggests that such internationalism should not be the intent of university research. Rather, research universities should try to confine themselves to studying fundamental educational problems. (KC)

  10. International Reaction to the Palestinian Unity Government

    National Research Council Canada - National Science Library

    Morro, Paul

    2007-01-01

    .... The international sanctions have not driven Hamas from power, and instead, some assert they may have provided an opening for Iran to increase its influence among Palestinians by filling the void...

  11. The future of morality and international justice

    Directory of Open Access Journals (Sweden)

    Rakić Vojin

    2010-01-01

    Full Text Available The focus of this paper will be on the issue of justice, specifically in international relations. In that context, a number of existing theories of international justice will be briefly reviewed. Afterwards, I will turn to the question of what justice actually is. The assertion that justice is based on the idea of freedom will be substantiated. I will attempt to support my position with Doyle's and Kant's argumentation. It will be concluded that there are robust arguments in favor of the thesis that our historical development is marked by a gradual expansion of freedom and justice. Furthermore, we have strong reasons to aspire liberal internationalism based on the idea of humanity's gradual approximation of some form of global state because such a conception might be the best warrant of justice in international relations.

  12. Page THE PROBLEM WITH INTERNATIONAL HUMANITARIAN LAW

    African Journals Online (AJOL)

    Fr. Ikenga

    Persons who international humanitarian law applies have .... problems in applying the principle of distinction and seeks to find a standard for distinguishing what may appear ..... The advantage of employing drones in armed operatin is that no.

  13. The fifth international conference on Arabidopsis research

    Energy Technology Data Exchange (ETDEWEB)

    Hangarter, R.; Scholl, R.; Davis, K.; Feldmann, K.

    1993-12-31

    This volume contains abstracts of oral and poster presentations made in conjunction with the Fifth International Conference on Arabidopsis Research held August 19--22, 1993 at the Ohio State University, Columbus, Ohio.

  14. Exploration of the perceptions of emergency physicians and interns regarding the medical documentation practices of interns.

    Science.gov (United States)

    Isoardi, Jonathon; Spencer, Lyndall; Sinnott, Michael; Nicholls, Kim; O'Connor, Angela; Jones, Fleur

    2013-08-01

    The primary objective of the present study was to learn the factors that influence the documentation practices of ED interns. A second objective was to identify the expectations of emergency physicians (EPs) towards the medical record documentation of ED interns. A qualitative design was adopted using semi-structured interviews in convenience samples drawn from both groups. Eighteen interviews were conducted with intern volunteers and 10 with EP volunteers. One (5%) intern and two (20%) EPs had received medical documentation training. Factors that encouraged interns' documentation included: patient acuity (the more critical the condition, the more comprehensive the documentation) and the support of senior colleagues. Inhibiting factors included uncertainty about how much to write, and the shift being worked (interns indicated they wrote less at night). Factors of consequence to senior personnel included the apparent reluctance of interns to document management plans. They noted that interns frequently confine their notes to assessment, investigations and treatments, whereas EPs preferred records that demonstrated intern thought processes and included such matters as future actions to follow immediate treatment. A positive theme that emerged included the high level of support interns received from their senior colleagues. Another theme, the influence of patient acuity, held both positive and negative implications for intern writing practices. The lack of formal training is an impediment to the production of useful medical records by ED interns. One solution proposed by both interns and senior personnel was the introduction of the subject into intern education programmes. © 2013 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

  15. Protectionism in the Current International Context

    Directory of Open Access Journals (Sweden)

    Botescu Ion

    2017-01-01

    The attempt to impose a set of international trade rules to be respected by world statesrepresents progress in this area. Further issues are related to how the agreed rules apply so thatthe benefits of international trade are placed in an equitable area. The global financial crisis, theBrexit, Trump's attitude as candidate and especially as US President are disturbing factors in thetrade relationships between states.

  16. Announcement by the Internal Transport Service

    CERN Multimedia

    2015-01-01

    The Shipping Service requests all users of wooden pallets, freight containers and lids that are no longer in use to contact the Internal Transport Service of the GS department (George Truelove), which is responsible for collecting and returning them to the Goods Reception Service in Buildings 904 and 194. Please also contact Mr. Truelove if you receive an order that is not meant for you. Internal Transport Service

  17. 78 FR 18321 - International Code Council: The Update Process for the International Codes and Standards

    Science.gov (United States)

    2013-03-26

    ... Energy Conservation Code. International Existing Building Code. International Fire Code. International... Code. International Property Maintenance Code. International Residential Code. International Swimming Pool and Spa Code International Wildland-Urban Interface Code. International Zoning Code. ICC Standards...

  18. Universal interface on Zynq{sup ®} SoC with CAN, RS-232, Ethernet and AXI GPIO for instrumentation & control

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Abhijeet, E-mail: akumar@ipr.res.in; Rajpal, Rachana; Pujara, Harshad; Mandaliya, Hitesh; Edappala, Praveenalal

    2016-11-15

    Highlights: • We have designed Universal Interface on Zynq{sup ®} SoC with CAN, RS-232, Ethernet and AXI GPIO for Instrumentation & Control. This project is based on Zynq{sup ®}-7000 family xc7z020clg484-1 chip. • We explored the full design flow starting from the hardware development in Vivado to software development in SDK using APIs in C language and then interfacing the host application developed in LabVIEW. • We also explored how to make custom IP with AXI bus interface in Vivado. • Useful for those who wants to make custom hardware on Zynq{sup ®} SoC. - Abstract: This paper describes an application developed on the latest Zynq{sup ®}-7000 All Programmable SoC (AP SoC) [1] devices which integrate the software programmability of an ARM{sup ®}-based processor with the hardware programmability of an FPGA, on a single device. In this paper we have implemented application which uses various interfaces like CAN, RS-232, Ethernet and AXI GPIO, so that our host application running on PC in LabVIEW can communicates with any hardware which has at least any one of the available interface. Zynq-7000 All Programmable SoCs (System On Chip) infuse customizable intelligence into today’s embedded systems to suit your unique application requirements. This family of FPGA is meant for high end application because it has huge resources on single chip. It offers you to make your own custom hardware IP, in fact we have made our custom IP called myIP in our design. The beauty of this chip is that it can write drivers for your custom IP which has AXI bus layer attached. After exporting the hardware information to the Software Development Kit (SDK), the tool is able to write drivers for your custom IP. This simplifies your development to a great extent. In a way this application provides the universal interfacing option to user. User can also write the digital data on the GPIO (General Purpose Input Output) through LabVIEW Test application GUI. This project can be used

  19. International Society for the Advancement of Cytometry cell sorter biosafety standards.

    Science.gov (United States)

    Holmes, Kevin L; Fontes, Benjamin; Hogarth, Philip; Konz, Richard; Monard, Simon; Pletcher, Charles H; Wadley, Robert B; Schmid, Ingrid; Perfetto, Stephen P

    2014-05-01

    Flow cytometric cell sorting of biological specimens has become prevalent in basic and clinical research laboratories. These specimens may contain known or unknown infectious agents, necessitating precautions to protect instrument operators and the environment from biohazards arising from the use of sorters. To this end the International Society of Analytical Cytology (ISAC) was proactive in establishing biosafety guidelines in 1997 (Schmid et al., Cytometry 1997;28:99-117) and subsequently published revised biosafety standards for cell sorting of unfixed samples in 2007 (Schmid et al., Cytometry Part A J Int Soc Anal Cytol 2007;71A:414-437). Since their publication, these documents have become recognized worldwide as the standard of practice and safety precautions for laboratories performing cell sorting experiments. However, the field of cytometry has progressed since 2007, and the document requires an update. The new Standards provides guidance: (1) for laboratory design for cell sorter laboratories; (2) for the creation of laboratory or instrument specific Standard Operating Procedures (SOP); and (3) on procedures for the safe operation of cell sorters, including personal protective equipment (PPE) and validation of aerosol containment. Published © 2014 Wiley Periodicals Inc.

  20. Corporate Managers' International Orientation and the Export ...

    African Journals Online (AJOL)

    Corporate Managers' International Orientation and the Export Performance of Firms in ... and for determining influence between interval level variables, respectively. ... Enhancing product adaptation and use of foreign strategic partnerships by ...