In Conversation with Paul Richards

Science.gov (United States)

Holman, Andrew

2013-01-01

Paul Richards is one of those individuals who make a difference and is as far from institutional as one can be. The author met up with him at the Learning Disability Today conference in London to talk more about his work and life. Paul coordinates the service user involvement across Southdown Housing Association, based in Sussex.

Obituary: Dr. Richard Roland Baker

Directory of Open Access Journals (Sweden)

Thornton R

2014-12-01

Full Text Available Richard Baker died at Easter 2007 after a very short illness. It is sad that he died so soon after his retirement from the British American Tobacco Company at the end of 2005, and just as he was beginning to enjoy his new life, even though tobacco science still had a part to play.

Richard W. Ziolkowski Receives Honorary Doctorate

DEFF Research Database (Denmark)

Breinbjerg, Olav

2012-01-01

At the annual Commemoration of the Technical University of Denmark (DTU) on April 27, 2012, Prof. Richard W. Ziolkowski, University of Arizona (UoA), received DTU's highest academic degree, the Honorary Doctor degree: Doctor Technices Honoris Causa (Figure 1). Prof. Ziolkowski has been a close...

Recensie "The Great Reset" : Richard Florida

NARCIS (Netherlands)

Roy van Dalm

2010-01-01

Like the Great Depression and the Long Depression before it, experts have viewed prolonged economic downturns as crises. In The Great Reset , bestselling author Richard Florida argues that we should instead see the recent recession as an opportunity to create entirely new ways of working and living

Seeing Scale: Richard Dunn’s Structuralism

Directory of Open Access Journals (Sweden)

Keith Broadfoot

2012-11-01

Full Text Available Writing on the occasion of a retrospective of Richard Dunn’s work, Terence Maloon argued that ‘structuralism had an important bearing on virtually all of Richard Dunn’s mature works’, with ‘his modular, “crossed” formats’ being the most obvious manifestation of this. In this article I wish to reconsider this relation, withdrawing from a broad consideration of the framework of structuralism to focus on some of the quite particular ideas that Lacan proposed in response to structuralism. Beginning from a pivotal painting in the 1960s that developed out of Dunn’s experience of viewing the work of Barnett Newman, I wish to suggest a relation between the ongoing exploration of the thematic of scale in Dunn’s work and the idea of the symbolic that Lacan derives from structuralist thought. This relation, I argue, opens up a different way of understanding the art historical transition from Minimalism to Conceptual art.

Theodore William Richards and the Periodic Table

Science.gov (United States)

Conant, James B.

1970-01-01

Discusses the contribution of Theodore Richards to the accurate determination of atomic weights of copper and other elements; his major contribution was to the building of the definitive periodic table of the elements. (BR)

Method of lines solution of Richards` equation

Energy Technology Data Exchange (ETDEWEB)

Kelley, C.T.; Miller, C.T.; Tocci, M.D.

1996-12-31

We consider the method of lines solution of Richard`s equation, which models flow through porous media, as an example of a situation in which the method can give incorrect results because of premature termination of the nonlinear corrector iteration. This premature termination arises when the solution has a sharp moving front and the Jacobian is ill-conditioned. While this problem can be solved by tightening the tolerances provided to the ODE or DAE solver used for the temporal integration, it is more efficient to modify the termination criteria of the nonlinear solver and/or recompute the Jacobian more frequently. In this paper we continue previous work on this topic by analyzing the modifications in more detail and giving a strategy on how the modifications can be turned on and off in response to changes in the character of the solution.

W. Richard Scott, Institutions and Organizations: Ideas, Interests, and Identities

DEFF Research Database (Denmark)

Jakobsen, Michael

2014-01-01

Book review of: W. Richard Scott: Institutions and Organizations: Ideas, Interests, and Identities. 4th edition. Thousand Oaks, CA: SAGE Publications, 2014. xiii, 345 pp.......Book review of: W. Richard Scott: Institutions and Organizations: Ideas, Interests, and Identities. 4th edition. Thousand Oaks, CA: SAGE Publications, 2014. xiii, 345 pp....

Kuues väljasuremine / Richard Leakey, Roger Lewin

Index Scriptorium Estoniae

Leakey, Richard

2002-01-01

Inimtegevuse hävitavast toimest looduslikule mitmekesisusele, mis tingib loodusliku energiatootmise järsu kahanemise, millest omakorda sõltub inimese enda ellujäämine. Lühidalt Richard Leakey'st

Bridging the Knowledge Gaps between Richards' Equation and Budyko Equation

Science.gov (United States)

Wang, D.

2017-12-01

The empirical Budyko equation represents the partitioning of mean annual precipitation into evaporation and runoff. Richards' equation, based on Darcy's law, represents the movement of water in unsaturated soils. The linkage between Richards' equation and Budyko equation is presented by invoking the empirical Soil Conservation Service curve number (SCS-CN) model for computing surface runoff at the event-scale. The basis of the SCS-CN method is the proportionality relationship, i.e., the ratio of continuing abstraction to its potential is equal to the ratio of surface runoff to its potential value. The proportionality relationship can be derived from the Richards' equation for computing infiltration excess and saturation excess models at the catchment scale. Meanwhile, the generalized proportionality relationship is demonstrated as the common basis of SCS-CN method, monthly "abcd" model, and Budyko equation. Therefore, the linkage between Darcy's law and the emergent pattern of mean annual water balance at the catchment scale is presented through the proportionality relationship.

Richard A. Werners forskning i pengeskabelse

DEFF Research Database (Denmark)

2016-01-01

Hvilken rolle spiller penge i samfundsøkonomien og hvilken rolle burde penge spille i den økonomiske videnskab? Det forsker Richard Werner i. Han er professor i økonomi ved Southampton University i England, og her præsenteres fire dele af hans forskning i penge: (1) Hvad foregår der egentlig i en...

Richard Mattessich: vida y obra

OpenAIRE

Daniel Carrasco Díaz

2006-01-01

El texto que se ofrece a continuación constituye el discurso pronunciado por el profesor Daniel Carrasco Díaz, catedrático de Economía Financiera y Contabilidad como padrino del homenajeado, en el solemne acto de investidura del Prof. Dr. Richard Mattessich, profesor emérito de la Sauder School of Commerce, de la University of British Columbia, Vancouver (Canadá), como Doctor honoris causa por la Universidad de Málaga, celebrado el 18 de mayo de 2006.

Failed Mothers, Monster Sons. Reading Shakespeare’S Richard Iii as a Fairy Tale

Directory of Open Access Journals (Sweden)

Percec Dana

2014-03-01

Full Text Available The paper looks at Shakespeare’s historical play Richard III and its fairy tale-like character given by the configuration of the main character as an arch-villain and the presence of motifs and patterns typically associated with the fairy tale genre. More specifically, it considers the mother-son relationship between the Duchess of York and Richard in the light of the motif of monstrous birth. It is not a coincidence that the emergence of such motifs coincides with the historical contexts of the early modern period. Reading Richard III in this key is related to the revisionist approach to chronicle plays.

Richard Weaver's Untraditional Case for Federalism

OpenAIRE

Jeremy David Bailey

2004-01-01

Although Richard M. Weaver's political writings do not offer a systematic examination of federalism, they include a defense of federalist arrangements. Because Weaver's federalism is central to his conservatism, and because his argument for federalism differs from more common conservative defenses of federalism offered in the twentieth century, his writings allow students of federalism to examine possible connections between federalism and conservative political thought. Copyright 2004, Oxfor...

In memoriam: Richard (Rick) G. Harrison—benefactor for ...

Indian Academy of Sciences (India)

Professor Richard Harrison (1946–2016), a most influential evolutionary biologist of ... were profoundly important in my development as a scientist and a person. ... observations to infer his love of family, but I am going to risk correction by those ...

PREFACE: Celebrating 20 years of Journal of Physics: Condensed Matter—in honour of Richard Palmer Celebrating 20 years of Journal of Physics: Condensed Matter—in honour of Richard Palmer

Science.gov (United States)

Ferry, David; Dowben, Peter; Inglesfield, John

2009-11-01

This year marks the 20th anniversary of the launch of Journal of Physics: Condensed Matter in 1989. The journal was formed from the merger of Journal of Physics C: Solid State Physics and Journal of Physics F: Metal Physics which had separated in 1971. In the 20 years since its launch, Journal of Physics: Condensed Matter has more than doubled in size, while raising standards. Indeed, Journal of Physics: Condensed Matter has become one of the leading scientific journals for our field. This could not have occurred without great leadership at the top. No one has been more responsible for this growth in both size and quality than our Senior Publisher, Richard Palmer. Richard first started work at IOP in March 1971 as an Editorial Assistant with J. Phys. B After a few months, he transferred to J. Phys.C The following year, the Assistant Editor of J. Phys. C, Malcolm Haines, left suddenly in order to work on his family vineyard in France, and Richard stepped into the breach. In those days, external editors had a much more hands-on role in IOP Publishing and he had to travel to Harwell to be interviewed by Alan Lidiard, the Honorary Editor of J. Phys. C, before being given the job of Assistant Editor permanently. Since J. Phys. C and J. Phys. F re-merged to form Journal of Physics: Condensed Matter, Richard gradually shed his other journal responsibilities, except for Reports on Progress in Physics, to build up Journal of Physics: Condensed Matter. He has worked closely with four Editors-in-Chief of J. Phys. C and five of Journal of Physics: Condensed Matter. When Richard announced his retirement this past winter, we met it with a great deal of both happiness and sadness. Of course, we are happy that he is going to be allowed to enjoy his retirement, but we remain very sad to lose such a valuable member of our team, especially the one who had provided the heart and soul of the journal over its 20 years. We will be able to rely upon the team which Richard ably trained as

Trochanteric fractures. Classification and mechanical stability in McLaughlin, Ender and Richard osteosynthesis

Energy Technology Data Exchange (ETDEWEB)

Herrlin, K.; Stroemberg, T.; Lidgren, L.; Walloee, A.; Pettersson, H.

Four hundred and thirty trochanteric factures operated upon with McLaughlin, Ender or Richard's osteosynthesis were divided into 6 different types based on their radiographic appearance before and immediately after reposition with special reference to the medial cortical support. A significant correlation was found between the fracture type and subsequent mechanical complications where types 1 and 2 gave less, and types 4 and 5 more complications. A comparison of the various osteosyntheses showed that Richard's had significantly fewer complications than either the Ender or McLaughlin types. For Richard's osteosynthesis alone no correlation to fracture type could be made because of the small number of complications in this group.

Richard Wollheim 1923-2003 / Marek Volt

Index Scriptorium Estoniae

Volt, Marek

2004-01-01

Järelehüüe anglo-ameerika filosoofile Richard Wollheimile (5. V 1923-4. XI 2003), kes huvitus maalist ja psühhoanalüüsist ning kuulub XX sajandi analüütilist kunstifilosoofiat enim kujundanud filosoofide hulka. Tema peamised tööd: "Art and Its Objects" (1968), "Painting As an Art" (1987), "On Painting and the Self" (1992). Ilmunud ka raamatus: Volt, Marek. Esteetikast. Tallinn : Sirp, 2006

Richard von Volkmann: surgeon and Renaissance man.

Science.gov (United States)

Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R; Mubarak, Scott J

2008-02-01

Richard von Volkmann (1830-1889), one of the most important surgeons of the 19(th) century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867-1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the "antiseptic technique" to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann's contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children's fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics.

75 FR 53730 - Culturally Significant Objects Imported for Exhibition Determinations: “Richard Hawkins-Third Mind”

Science.gov (United States)

2010-09-01

... DEPARTMENT OF STATE [Public Notice 7148] Culturally Significant Objects Imported for Exhibition Determinations: ``Richard Hawkins--Third Mind'' SUMMARY: Notice is hereby given of the following determinations... the exhibition ``Richard Hawkins--Third Mind,'' imported from abroad for temporary exhibition within...

Fluid flow in porous media using image-based modelling to parametrize Richards' equation.

Science.gov (United States)

Cooper, L J; Daly, K R; Hallett, P D; Naveed, M; Koebernick, N; Bengough, A G; George, T S; Roose, T

2017-11-01

The parameters in Richards' equation are usually calculated from experimentally measured values of the soil-water characteristic curve and saturated hydraulic conductivity. The complex pore structures that often occur in porous media complicate such parametrization due to hysteresis between wetting and drying and the effects of tortuosity. Rather than estimate the parameters in Richards' equation from these indirect measurements, image-based modelling is used to investigate the relationship between the pore structure and the parameters. A three-dimensional, X-ray computed tomography image stack of a soil sample with voxel resolution of 6 μm has been used to create a computational mesh. The Cahn-Hilliard-Stokes equations for two-fluid flow, in this case water and air, were applied to this mesh and solved using the finite-element method in COMSOL Multiphysics. The upscaled parameters in Richards' equation are then obtained via homogenization. The effect on the soil-water retention curve due to three different contact angles, 0°, 20° and 60°, was also investigated. The results show that the pore structure affects the properties of the flow on the large scale, and different contact angles can change the parameters for Richards' equation.

76 FR 10936 - Culturally Significant Objects Imported for Exhibition Determinations: “Richard Serra Drawing: A...

Science.gov (United States)

2011-02-28

... DEPARTMENT OF STATE [Public Notice: 7348] Culturally Significant Objects Imported for Exhibition Determinations: ``Richard Serra Drawing: A Retrospective'' SUMMARY: Notice is hereby given of the following... objects to be included in the exhibition ``Richard Serra Drawing: A Retrospective,'' imported from abroad...

Travelling wave solutions for the Richards equation incorporating non-equilibrium effects in the capillarity pressure

NARCIS (Netherlands)

van Duijn, C. J.; Mitra, K.; Pop, I. S.

2018-01-01

The Richards equation is a mathematical model for unsaturated flow through porous media. This paper considers an extension of the Richards equation, where non-equilibrium effects like hysteresis and dynamic capillarity are incorporated in the relationship that relates the water pressure and the

78 FR 43093 - Richard C. Theuer; Filing of Food Additive Petition and Citizen Petition

Science.gov (United States)

2013-07-19

... [Docket Nos. FDA-2013-F-0700 and FDA-2013-P-0472] Richard C. Theuer; Filing of Food Additive Petition and... proposing that the food additive regulations be amended to prohibit the use of carrageenan and salts of... that Richard C. Theuer, Ph.D., 7904 Sutterton Ct., Raleigh, NC 27615, has filed a food additive...

When Richard Branson wants to build his own facility; Quand Richard Branson veut construire son propre complexe

Energy Technology Data Exchange (ETDEWEB)

Cosnard, D

2005-10-01

The capacity of petroleum refineries is today insufficient to meet the demand. In front of this shortage, Sir Richard Branson, the owner of Virgin Atlantic Airways, has decided to invest in the building of a refinery in Europe or in Canada. His new company, Virgin Oil, is already launched. However, the setting up of a new facility is very expensive and raises important problems of permits and public contestation which remain to be solved. Short paper. (J.S.)

Reading 'blackface': A (narrative) introduction to Richard Kearney's ...

African Journals Online (AJOL)

Prominent Irish philosopher Richard Kearney's notion of 'carnal hermeneutics' is introduced by applying it to a case study of a recent event that took place at one of South Africa's university campuses. The narrative assists in illuminating some of the core principles of carnal hermeneutics and illustrates the applicability of ...

H.E. Mr Richard J. Fredericks, Ambassador of the United States of America to Switzerland

CERN Document Server

Patrice Loïez

2001-01-01

Photo 01 : Prof. L. Maiani, CERN Director-General, gives a piece of LHC super conducting wire to H.E. Mr. Richard J. Fredericks; Photo 02 : Prof. L. Maiani, CERN Director-General, Mr. Jan van der Boon, CERN Director of Administration and H.E. Mr. J. Richard Fredericks

Success: Richard Dyer on Diana Ross [and Beyond

NARCIS (Netherlands)

Kooijman, J.

2016-01-01

In June 1982, film scholar Richard Dyer published a two-page essay on African-American star Diana Ross in the journal Marxism Today. Part of Dyer’s essay focuses on the American conception of success and specifically on how Ross is one of the few black artists who has been "allowed" to be such a

Richard Feynman Quarks, Bombs, and Bongos

CERN Document Server

Henderson, Harry

2010-01-01

Described by his peers as the "finest physicist of his generation," Richard Feynman defied scientist stereotypes. This brash New York-born American physicist startled the more conservative giants of European physics with his endless ability to improvise. Indeed, later in life, Feynman became an accomplished bongo player. Feynman's legacy to physics was his ability to simplify complex equations and clarify fundamental principles through the use of graphs. He developed the theory of quantum electrodynamics, which illustrates the behavior of electrically charged particles, such as elect

To Have Been a Student of Richard Feynman

Indian Academy of Sciences (India)

Excerpt from Most of the Good Stuff: Memories of Richard Feynman, 1993, ... of Feynman, but while it inspired us to try for originality after we left Cornell, it also lowered our productivity to a point that at times was dangerous to our academic careers. In truth .... (However, my actual thesis topic turned out to be a different one.).

An appreciation of Richard Threlkeld Cox

Science.gov (United States)

Tribus, Myron

2002-05-01

Richard T. Cox's contributions to the foundations of probability theory and inductive logic are not generally appreciated or understood. This paper reviews his life and accomplishments, especially those in his book The Algebra of Probable Inference and his final publication Inference and Inquiry which, in this author's opinion, has the potential to influence in a significant way the design and analysis of self organizing systems which learn from experience. A simple application to the simulation of a neuron is presented as an example of the power of Cox's contribution.

Richard H. Thaler: Wirtschaftsnobelpreisträger 2017

OpenAIRE

Bruttel, Lisa Verena; Stolley, Florian

2017-01-01

Der diesjährige Nobelpreisträger Richard H. Thaler ist einer breiteren Öffentlichkeit vor allem durch sein mit Cass R. Sunstein gemeinsam verfasstes Buch zum Nudging bekannt geworden. Tatsächlich hat er in den vergangenen 40 Jahren die Entwicklung der Verhaltensökonomie entscheidend mitgeprägt und vorangebracht. Thaler hat die Annahmen hinter dem Modell des Homo oeconomicus untersucht und die Abweichungen menschlichen Verhaltens von den Rationalitätsannahmen auf zwei wesentliche Ursachen zurü...

Technical realization of a closure concept for a chamber-system in the underground Richard repository in the Czech Republic

International Nuclear Information System (INIS)

Kucerka, Miroslav

2006-01-01

The Phare project CZ 632.02.04 'Realization of closure of a chamber in the Richard repository as input for establishing a safety case' is a follow up implementation phase of the Phare project, CZ 01.14.03 'Solution for closure of a chamber in the Richard repository'. Main objective of both projects is to propose and realize a disposal system in selected chambers of the Richard repository, which will eliminate burden from the past practices in waste management during the first phase of the Richard repository operation (1965 - 1980) and which will improve its overall long term safety. This objective will be assured by realization of the concept of so called 'hydraulic cage', which technical solution was developed by DBE Technology within the Phare project CZ 01.14.03. The solution is described in the previous presentation 'Hydraulic Cage Concept for Waste Chambers and its Technical Implementation for the Underground Richard Repository, Litomerice, Czech Republic'. (author)

Illustrated & Dissected: Professor Richard Sawdon Smith.

Science.gov (United States)

2015-06-01

This Alternative Gallery feature introduces the photographic artist Professor Richard Sawdon Smith. Professor Sawdon Smith's work stems around a fascination with representations of anatomy that have been fuelled by his experience as a hospital patient. The work has allowed him to explore ideas through the use of medical illustrations which include early anatomical drawings, personal medical photography and facial modelling. The work highlights how such imagery can be used in the context of a patient seeking understanding and acceptance of ill health and disease using the body as a canvas on which to translate the experience.

Richard Feynman a life in science

CERN Document Server

Gribbin, John

1998-01-01

This text is a portrayal of one of the greatest scientists of the late 20th-century, which also provides a picture of the significant physics of the period. It combines personal anecdotes, writings and recollections with narrative. Richard Feynman's career included: war-time work on the atomic bomb at Los Alamos; a theory of quantum mechanics for which he won the Nobel prize; and major contributions to the sciences of gravity, nuclear physics and particle theory. In 1986, he was able to show that the Challenger disaster was due to the effect of cold on the booster rocket rubber sealings.

Richard Bright and his neurological studies.

Science.gov (United States)

Pearce, J M S

2009-01-01

Richard Bright was one of the famous triumvirate of Guy's Hospital physicians in the Victorian era. Remembered for his account of glomerulonephritis (Bright's disease) he also made many important and original contributions to medicine and neurology. These included his work on cortical epileptogenesis, descriptions of simple partial (Jacksonian) seizures, infantile convulsions, and a variety of nervous diseases. Most notable were his reports of neurological studies including papers on traumatic tetanus, syringomyelia, arteries of the brain, contractures of spinal origin, tumours of the base of the brain, and narcolepsy. His career and these contributions are outlined. Copyright 2009 S. Karger AG, Basel.

Lipid imaging by mass spectrometry - a review.

Science.gov (United States)

Gode, David; Volmer, Dietrich A

2013-03-07

Mass spectrometry imaging (MSI) has proven to be extremely useful for applications such as the spatial analysis of peptides and proteins in biological tissue, the performance assessment of drugs in vivo or the measurement of protein or metabolite expression as tissue classifiers or biomarkers from disease versus control tissue comparisons. The most popular MSI technique is MALDI mass spectrometry. First invented by Richard Caprioli in the mid-1990s, it is the highest performing MSI technique in terms of spatial resolution, sensitivity for intact biomolecules and application range today. The unique ability to identify and spatially resolve numerous compounds simultaneously, based on m/z values has inter alia been applied to untargeted and targeted chemical mapping of biological compartments, revealing changes of physiological states, disease pathologies and metabolic faith and distribution of xenobiotics. Many MSI applications focus on lipid species because of the lipids' diverse roles as structural components of cell membranes, their function in the surfactant cycle, and their involvement as second messengers in signalling cascades of tissues and cells. This article gives a comprehensive overview of lipid imaging techniques and applications using established MALDI and SIMS methods but also other promising MSI techniques such as DESI.

Quasi-constitutional change without intent : A response to Richard Albert

NARCIS (Netherlands)

Passchier, Reijer

2017-01-01

Recently, Buffalo Law Review published Richard Albert’s article on “quasi-constitutional amendments.” These are, in Albert’s words, “sub-constitutional changes that do not possess the same legal status as a constitutional amendment, that are formally susceptible to statutory repeal or revision, but

Koht, kust tagasi ei tulda / Mark Jenkins ; fotod Cory Richards

Index Scriptorium Estoniae

Jenkins, Mark

2015-01-01

National Geographicu ekspeditsiooni, mille koosseisu kuulusid Renan Ozturk, Mark Jenkins, Cory Richards, Emily Harrington ja Kilaree O'Neill, püüdlustest tõusta Kagu-Aasia kõrgeima mäe Hkakabo Razi tippu ning mõõta selle täpset kõrgust GPS-i abil

Wooing-Scenes in “Richard III”: A Parody of Courtliness?

Directory of Open Access Journals (Sweden)

Agnieszka Stępkowska

2009-11-01

Full Text Available In the famous opening soliloquy of Shakespeare’s Richard III, Richard mightily voices his repugnance to “fair well-spoken days” and their “idle pleasures”. He realizes his physical deformity and believes that it sets him apart from others. He openly admits that he is “not shaped for sportive tricks, nor made to court an amorous looking-glass”. Yet, his monstrosity constitutes more perhaps of his aggressive masculine exceptionality rather than of his deformity. Richard’s bullying masculinity manifests itself in his contempt for women. In the wooing scenes we clearly see his pugnacious pursuit of power over effeminate contentment by reducing women to mere objects. Additionally, those scenes are interesting from a psychological viewpoint as they brim over with conflicting emotions. Therefore, the paper explores two wooing encounters of the play, which belong the best examples of effective persuasion and also something we may refer to as ‘the power of eloquence’.

Richard Kelly: Pioneirismo na iluminação da arquitetura moderna

Directory of Open Access Journals (Sweden)

Fernanda Brito Bandeira

2018-04-01

Full Text Available Livros resenhado: NEUMANN, Dietrich; STERN, Robert A. M. The structure of light: Richard Kelly and the illumination of modern architecture. New York: Yale University Press, 2010, 214 p. ISBN: 978-0-300-16370-4

Richard Rorty's Conception of Philosophy of Education Revisited

Science.gov (United States)

Noaparast, Khosrow Bagheri

2014-01-01

In this essay Khosrow Bagheri Noaparast argues that, by focusing on acculturation and edification, Richard Rorty has provided a promising view for education because without acculturation, education turns into a destructive endeavor, and without edification, education risks the danger of being repetitive and reproductive. However, Rorty's view…

The Paradox of the Public Realm in Richard Rorty

Directory of Open Access Journals (Sweden)

Martha Palacio Avendaño

2008-12-01

Full Text Available The concepto of the public sphere in Richard Rorty's philosophy, inherited of liberal tradition, allows be treated as a part of a game of language called democratic liberalism. One of the rules for validating a move in this game consists in taking for granted the distinction between the public and the private spheres. Richard Rorty thought that democratic liberalism did not need any foundation beyond the way to play it; its only criteria would be the game's practices, according an utopia which would allow us to make more movements in the game. That is, democratic liberalism does not require foundations, but just practices for achieving a social hioe inspired on freedom and pluralism. This kind of utopia, based upon the non-cruelty principle, would make possible an inclusive society where everyone would have a place for their own private vocabulary. In this way, Rorty would have linked freedom and solidarity. However, this language-game reveals the paradox of the link which implies the meaning of the public shere. Herein, freedom is not a sufficient condition of solidarity; hence, there is no place for social inclusion in Rorty's language game.

Has Richard Rorty a moral philosophy?

Directory of Open Access Journals (Sweden)

Mohammad Asghari

2015-06-01

Full Text Available I try to show that Richard Rorty, although is not a moral philosopher like Kant, nerveless, has moral philosophy that must be taken seriously. Rorty was not engaged with moral philosophy in the systematic manner common among leading modern and contemporary moral philosophers. This paper has two parts: first part, in brief, is concerned with principles of his philosophy such as anti-essentialism, Darwinism, Freudism, and historicism. Second part which be long and detailed, considers many moral themes in Rorty's thought such as critique of Kantian morality, solidarity, moral progress, cruelty and concept of other, etc. Subsequently, I will try to answer the research question of the article namely, has Rorty a moral philosophy?

Whatever Happened to Richard Reid's List of First Programming Languages?

Science.gov (United States)

Siegfried, Robert M.; Greco, Daniel M.; Miceli, Nicholas G.; Siegfried, Jason P.

2012-01-01

Throughout the 1990s, Richard Reid of Michigan State University maintained a list showing the first programming language used in introductory programming courses taken by computer science and information systems majors; it was updated for several years afterwards by Frances Van Scoy of West Virginia University. However, it has been 5 years since…

Richard Wright, Toni Morrison, and United States book clubs

Directory of Open Access Journals (Sweden)

Mark Madigan

2004-12-01

Full Text Available This essay focuses on the influence of commercial book clubs in the United States. It will examine the country's oldest commercial book club, the Book-of-the-Month Club (BOMC, Oprah's Book Club (OBC, which bears the name of its founder, television personality Oprah Winfrey, and their roles in the careers of two African-American authors, Richard Wright and Toni Morrison.

Argument from Design in Richard Baxter's Natural Theology

Directory of Open Access Journals (Sweden)

Igor Koshelev

2017-12-01

Full Text Available The article deals with the teleological argument, or argument from design, as expounded by a famous English Protestant theologian Richard Baxter, one of the leading 17-th century English Puritans, in his work “The Reasons of the Christian Religion”. Natural theology, providing arguments for the existence of God based on reason and without appeal to the Revelation, has always played a vital role throughout the entire history of theological thought. The most popular was the so called teleological argument, or the argument from design, which stands out among all rational arguments for the existence of the Creator. It is mostly known from the “Fifth Way” of the medieval Scholastic philosopher Thomas Aquinas and a famous work “Natural Theology” by an English 19-th century theologian William Paley. The foundation for the modern research in the area was laid during the age of the Scientific Revolution of the 17th century English nature philosophers and theologians, especially Robert Boyle, who believed the teleological argument to be the key element of Natural Theology. His friend and confessor, Richard Baxter, a prominent representative of the Puritan Natural Theology, mostly known by his theological works, paved the way for Natural Theology both in his own time and the following centuries. His work was thought to be the best collection of the evidences for Christianity.

Response to Richard Widdess: Music, Meaning and Culture

Directory of Open Access Journals (Sweden)

Jerome Lewis

2012-09-01

Full Text Available This commentary discusses the anthropological implications of Richard Widess’ paper by summarizing some anthropological approaches to music, especially focusing on the way musical participation inculcates and transmits an aesthetic orientation that guides action across cultural domains such as politics, economics and religion. The paper ends by suggesting that the heart of human culture is more likely to be an aesthetic orientation than a script or set of rules, and traces out some reasons why music does this so well.

Review: Lyn Richards (2005. Handling Qualitative Data: A Practical Guide

Directory of Open Access Journals (Sweden)

Robert L. Miller

2006-03-01

Full Text Available Handling Qualitative Data: A Practical Guide is an introductory textbook covering all stages of qualitative research from the initial conceptualisation of a project, through data collection and analysis, to writing up. The author, Lyn RICHARDS, is a well-known developer of two key qualitative software analysis packages, NUD*IST and NVivo. While RICHARDS clearly advocates the use of qualitative analysis software, the text is "generic" and could be used in tandem with any qualitative software package. The book concentrates on practical advice about the use of software to manage and analyse qualitative data, and provides insights in these areas. The consideration of issues around team-based qualitative research is another strong point. However, due in part to its short length, the overall coverage of topics tends to be superficial. In itself, the book does not provide sufficient detailed support for a student who would like to use it as her/his main source of guidance for carrying out a qualitative research project. URN: urn:nbn:de:0114-fqs0602244

Drawings of fossils by Robert Hooke and Richard Waller

Science.gov (United States)

Kusukawa, Sachiko

2013-01-01

The drawings of fossils by Robert Hooke and Richard Waller that were the basis of the engravings in Hooke's Posthumous works (1705) are published here for the first time. The drawings show that both Hooke and Waller were proficient draftsmen with a keen eye for the details of petrified objects. These drawings provided Hooke with a polemic edge in making the case for the organic origins of ‘figured stones’.

Justiça e sociedade liberal em Richard Rorty: justiça como lealdade e o projeto social de uma utopia

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Marcelo de Almeida Silva

2014-07-01

Full Text Available O presente texto pretende explorar o conceito de justiça de Richard Rorty e a proposta da Utopia Liberal que o autor apresenta. Para tanto, explora, dentro da obra de Richard Rorty e de alguns autores com quem dialoga, contribuições para o debate da concepção do termo Justiça como um senso de lealdade ampliada e de sua proposta para uma sociedade mais justa, igualitária e inclusiva.   Abstract: This paper aims to explore the concept of justice from Richard Rorty and his proposal about the idea of a Liberal Utopia. With this goal we seek, within the work of Richard Rorty, and some authors with whom he converses, contributions to the discussion of the conception of justice as an expanded sense of loyalty and his proposal for a fairer, equitable and inclusive society.   Resumen: Este trabajo se propone explorar el concepto de justicia de Richard Rorty y la propuesta de liberal utopía que el autor presenta. Con este objetivo, vamos a buscar en la obra de Richard Rorty, y algunos autores con los que conversa, contribuciones a la discusión sobre la concepción de la justicia como un sentido más amplio de la lealtad y su propuesta de una sociedad más justa, equitativa e incluyente.

Strauss, Richard. Ariane a Naxos: opera seulement, integrale. Miliza Korjus / Michel Parouty

Index Scriptorium Estoniae

Parouty, Michel

1995-01-01

Uuest heliplaadist "Strauss, Richard. Ariane a Naxos: opera seulement, integrale. Miliza Korjus (Najade). Orchestre de l'Opea l'Efat de Vienne" Arlecchino ARL 14-16, distribution Dante (3 CD: 390 F). 1935, 1944. TT: 3h 46'17"

Making the Road While Walking It: A Conversation with Richard Simpson

Science.gov (United States)

Zabel, Robert H.; Kaff, Marilyn; Teagarden, James

2016-01-01

Richard Simpson is professor of special education at the University of Kansas (KU). Dr. Simpson's duties at KU have included roles of staff psychologist, teaching associate, assistant professor, project director, associate professor, professor, and chairperson for the Department of Special Education. He has directed numerous University of Kansas…

Lendab nagu kotkas üle maailmas kogutud tarkuse / Richard Aroksaar ; intervjueerinud Ene Riet

Index Scriptorium Estoniae

Aroksaar, Richard

2014-01-01

Intervjuu eestlase Richard Aroksaarega, kes õppinud psühholoogiat ja raamatukogundust, töötab USA Rahvusparkide Ühenduse raamatukogus (National Park Service Library, NPS) süsteemi raamatukoguhoidja ja administraatorina

Prof. Richard Mattessich at 95. His Research Methodology

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Giuseppe Galassi

2017-12-01

Full Text Available This paper is presented as a tribute to prof. Richard Mattessich. It is written “through the eyes” of a researcher who has worked closely with him over a period of 42 years, starting attending his courses of “Income Determination Theory” and “Research Methodology” at the University of British Columbia in 1975. Among his huge scientific research and publications, I intend to underline these three major contributions: (i Accounting metrics and other mathematical instruments which anticipated computer spreadsheet by 30 years; (ii. The preparation of accountants for information economics by means of analytical methods; and (iii The proposition of the “onion model of reality” to distinguish different Kind of reality. Este trabajo se presenta como un tributo al profesor Richard Mattessich. Está escrito “con los ojos” de un investigador que ha trabajado estrechamente con él durante un período de 42 años, comenzando a asistir a sus cursos de " Income Determination Theory" y "Research Methodology" en la Universidad de British Columbia en 1975. Entre su investigación y publicaciones, más importantes pretendo subrayar estas tres contribuciones principales: (i Accounting metrics and other mathematical instruments which anticipated computer spreadsheet by 30 years; (ii The preparation of accountants for information economics by means of analytical methods; y (iii The proposition of the “onion model of reality” to distinguish different Kind of reality.

Swearing Used in Richard Wright’s Black Boy

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Giyatmi Giyatmi

2017-07-01

Full Text Available This research aims at finding the types of swearing expressions and linguistic forms of English swearing used in Richard Wright’s Black Boy. This is a descriptive qualitative research since it describes the phenomena of swearing used in the novel. The data of the research are all the conversations or sentences used swearing in the novel written by Richard Wright namely Black Boy as the main data source. The method of collecting data in this research is observation and teknik lanjut catat. After all the data had been collected then they are coded using the coding system such as data number/title of novel/chapter/page/data. There is no data reduction since all the data are analyzed in this research. This research used theory triangulation. Kind of swearing expressions found in this novel dealing with God and religion terms, name of  animals and plants, part of body, racial terms, stupidity terms, name of occupation, sexual terms, family terms. The linguistic forms of English swearing used in this novel are word, phrase, and clause. The swearing in the form of words consists of (1 noun referring to place, person, occupation, animal, and idea (2 verb and (3 adjective. Phrase consists of (1 noun phrase with swearing functioning as headword, modifier, and both headword and modifier, (2 adjective phrase with swearing functioning as modifier. Swearing expression is also found in the form of sentence.

Historical Investigations of the Richard B. Russell Multiple Resource Area.

Science.gov (United States)

1981-11-01

period of this project as a contemporary c~lebration and a reiteration of an ancient folk construction, Stonehenge . Appropriately, as this document goes to...55, 56m, 59m, 64m, 65-68, 71- Stonehenge 216 72, 75-76, 79-84, 84m, 91, 94- Sutch, Richard 20 95, 100, lOlm, 102, 103, 121m, Swift, James Y. 195 126

Review of Richard Bausch, Hello to the Cannibals

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Géraldine Chouard

2006-03-01

Full Text Available Richard Bausch is credited with five collections of short stories and nine novels that have received various awards in the United States. His latest work, Hello to the Cannibals, blends a historical epic and a more intimate tale. Watch out‑this is a voracious novel.Other CarnageAn ethnologist investigating cannibalistic rites in Africa asks the head of the tribe : « Do you still have cannibals in your tribe ? » « No, we ate the last one yesterday, » answers the head of the tribe. Undoubtedly,...

El vocabulario sechurano de Richard Spruce

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Matthias Urban

2015-12-01

Full Text Available This paper makes accesible a new transcription of Richard Spruce’s vocabulary of the Sechura language. Collected in the mid-19th century by the British botanist, it constitutes one of only two sources of data for this language of northernmost Peru. A comparison of the original with previously published versions shows serious errors in transcription, in particular in those of Otto von Buchwald and Jacinto Jijón y Camaaño. The article also discusses the probable circumstances of data collection and the publication history of the hitherto known version, and concludes with some first observations on the significance of Spruce’s wordlist for elucidating the linguistic history of the region, in particular with regard to the question of the linguistic situation at Olmos.

Transforming Faith: H. Richard Niebuhr and Paulo Freire on Moral Education

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Daniel, Joshua Leonard

2013-01-01

Through a contextual comparison of the theological ethics of H. Richard Niebuhr and the educational theory of Paulo Freire, I argue that socialization, while an essential task of moral education, is an insufficient aim. The proper aim of moral education is individual development. The intention of my argument is address tendencies towards…

When Richard Branson wants to build his own facility

International Nuclear Information System (INIS)

Cosnard, D.

2005-01-01

The capacity of petroleum refineries is today insufficient to meet the demand. In front of this shortage, Sir Richard Branson, the owner of Virgin Atlantic Airways, has decided to invest in the building of a refinery in Europe or in Canada. His new company, Virgin Oil, is already launched. However, the setting up of a new facility is very expensive and raises important problems of permits and public contestation which remain to be solved. Short paper. (J.S.)

Richard Carwardine and Jay Sexton, eds., The Global Lincoln.

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Hans Krabbendam

2012-06-01

Full Text Available Most countries have their export heroes that transcend their national origin: India has its Ghandi, South Africa its Mandela, England its Churchill, and the US has Abraham Lincoln. While particularly known for his role in the American Civil War, he has developed into an international beacon for liberalism and democracy, especially for nationals deprived of this liberties.This collection of essays, edited by Corpus Christi College (Oxford, UK colleagues Richard Carwardine and Jay Sexton, puts...

Ripples from a Passing Ship: Memories; and a Legacy of Richard Peters

Science.gov (United States)

Harris, Kevin

2013-01-01

This paper outlines aspects and dimensions of my "relationship" with Richard Peters from 1966 onward. The underlying suggestion is that, while Peters' contribution to philosophy of education was undeniably of major proportions, both that contribution and his legacy are institutional rather than substantive. (Contains 15 notes.)

Süütuse kaotamine / Richard Branson ; intervjueerinud Peter Fisk ; tõlkinud Endrik Randoja

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Branson, Richard

2009-01-01

Turunduskirjanik Peter Fiski intervjuu Suurbritannia ärimagnaadi Sir Richard Bransoniga, milles arutletakse ettevõtja suurimate saavutuste ja suurimate pettuste üle, uuritakse Bransoni võimet juhtida oma 450 ettevõtet, tema suhtumist konkurentsi ning uutesse äriideedesse, samuti tema ajakasutust

Obituary: Richard D. Schwartz (1941-2011)

Science.gov (United States)

Wilking, Bruce

2011-12-01

Richard D. Schwartz, Professor Emeritus of Astronomy, died at his home in Sequim, WA, after a nearly 3 year battle against pancreatic cancer. Richard was born in Pretty Prairie, Kansas. He was active in sports and band and graduated in 1959. After completing a BS at Kansas State, and a Master's degree in Divinity at Union Seminary in NY, he further studied astrophysics, receiving his doctorate from University of Washington in 1973. When Dick arrived at the University of Missouri-St. Louis in 1975, he was the only astronomer in the Department of Physics. He built the astronomy program and initiated the B.S. in physics with an astrophysics option that the majority of physics majors choose. Dick was a wonderful teacher and provided outstanding leadership to the campus. He designed and provided oversight on the construction of the campus observatory that was completed in 1981. Since that time the observatory has served as both a teaching and research facility. It is also used for monthly public open houses that draw hundreds of people annually to the campus to view the moon, stars, and planets. Upon his retirement in 2003, the Board of Curators approved naming the campus observatory the "Richard D. Schwartz Observatory" in honor of his distinctive service to the University of Missouri-St. Louis. Just as important as Dick's service to promote public interest in astronomy was his effort to make the campus observatory a research facility. Dick equipped and maintained the observatory with state-of-art detectors that allowed students to get their first taste of scientific research. From 1991-2003, he managed the campus program for the NASA/Missouri Space Grant Consortium and mentored over 30 research students in projects at the observatory. Some of the results have been published in astronomical journals. Many of those students went on to graduate schools and several have achieved tenure and distinction at major universities. In addition to Dick's service to the University

Efficacy Quotient Tindakan ESWL Piezolith Richard Wolf 3000 pada Penderita Batu Ureter di RSUPN Dr. Cipto Mangunkusumo, 2008–2011

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Vinny Verdini

2017-01-01

Full Text Available Extracorporeal shockwave lithotripsy (ESWL saat ini telah menjadi metode yang paling umum dalam tatalaksana aktif batu ureter. Sejak Maret 2008, RSCM telah menggunakan mesin ESWL piezolith 3000 richard wolf dan belum diketahui nilai efficacy quotient (EQ. Penelitian ini bertujuan untuk menentukan nilai EQ dari tindakan ESWL menggunakan mesin piezolith richard wolf 3000 pada batu ureter dan hubungan angka bebas batu dengan lokasi batu, jumlah batu, beban batu, opasitas batu, obstruksi, dan fungsi ginjal. Studi cross sectional ini dilakukan pada bulan Januari 2008-Desember 2011 dan data dianalisis dengan statistik multivariat. Terdapat 113 (95 % dari 119 pasien yang dinyatakan bebas batu setelah tindakan ESWL pertama. Didapatkan nilai EQ 0,89. Hanya ukuran batu yang mempengaruhi angka bebas batu dalam penelitian ini (p<0,05. Disimpulkan bahwa prosedur ESWL menggunakan mesin richard wolf piezolith 3000 memiliki nilai EQ dan angka bebas batu yang lebih baik daripada mesin-mesin sebelumnya dan mesin lain yang sejenis. Faktor yang mempengaruhi keberhasilan adalah ukuran batu ureter yang ditatalaksana.Kata Kunci: batu ureter, ESWL, efficacy quotient, angka bebas batu. Efficacy Quotient of ESWL Piezolith Richard Wolf 3000 Machine in Patientswith Ureteral Stones in Dr. Cipto MangunkusumoNational Hospital 2008 - 2011AbstractExtracorporeal shockwave lithotripsy (ESWL is the most common method of ureteral stone management. Since 2008, RSCM has ben using ESWL piezolith 3000 richard wolf and efficacy quotient (EQ value have not yet studied. The study aims was to determine the efficacy quotient (EQ of ESWL using piezolith richard wolf 3000 machine for ureteral stone by analyzing free-stone rate with location of stones, number of stones, stone burden, stone opacity, obstruction and kidney function. This cross sectional study was carried out in January 2008-December 2011, with multivariate analytical study. Ninety five percent (n=113 of 119 patients were

Richard Wollheim über die Metapher in der Malerei

OpenAIRE

Heinrich, Richard

1993-01-01

Es handelt sich um den Text eines Vortrages, den ich Jänner 1993 im Rahmen einer Vortragsreihe am Institut für Kunstgeschichte der Universität Wien gehalten habe. Er ist bisher unpubliziert und nicht redigiert. Das worüber ich spreche ist ein Artikel von Richard Wollheim mit dem Titel "Die Metapher in der Malerei". Diesen Artikel habe ich herausgegeben, gemeinsam mit meinem Kollegen Helmuth Vetter, 1991 in dem Band "Bilder der Philosophie". Ursprünglich handelt es sich um einen Vortrag, d...

RICHARD WAGNER E O ROMANTISMO ALEMÃO

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Rainer Câmara Patriota

2015-07-01

Full Text Available A cultura musical romântica encontra em Richard Wagner– em sua obra musical e teórica – um de seus maiores protagonistas.A rejeição da Aufklärung e a exaltação da supremacia germânica –elementos constituidores da Weltanschauung romântica alemã –caracterizam fortemente o pensamento e a atitude de Wagner frenteà vida, assumindo conotações ainda mais radicais através de seucontumaz antissemitismo. De modo que pensar Wagner por ocasiãode seu bicentenário também significa retomar uma discussão crucialsobre o romantismo alemão e suas implicações políticas eideológicas.

Conoscenza e etica in Richard Rorty

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Emilia Romano

2011-12-01

Full Text Available The era in which we live, characterized by multiculturalism and complexity, it is a time when it is clear the difficulty of man to orient and to choose their own way. It’s the time of the fall of every certainty, is the era of “post”, after the tradition, after metaphysics, after the truth, and that requires more effort than any other constant reflection. The neopragmatismo seems to be an effective investigative tool for conducting this reflection and a vantage point to carry on a conversation around the issues of education. In particular, the author intended to refer to the work of Richard Rorty, the author who more than others reflected on the encounter between two important pragmatist tradition: that of classical pragmatism and the “continental” or responsible for the development of a new European concept of truth, understood as a critical and interpretative.

Resisting Biopolitics through “Diaphanous Wonder”: Richard Flanagan's Gould's Book of Fish

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Wiese, Doro|info:eu-repo/dai/nl/304842699

2014-01-01

In Gould's Book of Fish (2003), author Richard Flanagan manages to invent a format in which content and style account for historical events on Sarah Island, Tasmania in the 1820s, yet he does so in a manner that is not in the least objective, disinterested or fact-orientated. The perspective of

"Symposium" by Richard Dawkins, Gerard 't Hooft, Alain Connes

CERN Multimedia

Maximilien Brice

2004-01-01

Richard Dawkins will speak on biology, Gerard ‘t Hooft will focus on physics, and Alain Connes will discuss mathematics. CERN scientists probe ever-deeper levels of matter and their interactions, but can we say that the patterns they see are truly fundamental? Does the universe obey the same laws throughout? Since mathematical constructions can be true in the absence of any relation to the physical world, is mathematics more fundamental than physics? Extraterrestrial life would probably look much different from that on Earth, but natural selection still be fundamental to their evolution?

Juvenile Cosmology; Or Richard Powers’ Post-Global Doughnut

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Judith Roof

2010-02-01

Full Text Available Le roman de Richard Powers, Operation Wandering Soul (1993, présente le lien subtil qui associe un mondialisme déjà usé et vieillissant à l’enfant perçu comme catégorie dominante. Comme les faces serpentines d’un ruban de Möbius lové autour de l’illimité et de l’intemporel, le texte, tendu entre ses deux infinis – l’univers et l’enfant – révise la portée, la conception, la structure et le style du genre romanesque. Délaissant Aristote pour Einstein, Operation Wandering Soul se place sur le terrain de la cosmologie. Le récit, qui rassemble la kyrielle des grands ralliements juvéniles et leurs vains pèlerinages, concentre l’espace-temps dans une présentation qui évoque la « somme des histoires » de Richard Feynman. La contraction de l’espace-temps opérée par le roman ne fait pas de celui-ci un hymne simpliste au global (catégorie déjà aussi datée que celle des malheureux vétérans du Vietnam, mais capte au contraire la conscience grandissante d’une existence sans origine qui s’étend à perte de vue au-delà de ses coordonnées supposées. Le roman s’enroule sur lui-même tout en s’épanchant au dehors, boucle ses cadres et ses détours tout en desserrant leur emprise. Il fait tourner la roue de ses récits comme des planètes en rotation, la ronde d’un système solaire, le tourbillon d’une galaxie. La conscience que présente Operation Wandering Soul ne se résume donc pas au seul point de vue de l’âme errante qu’est le personnage de Kraft, mais consiste en la somme de tous les temps et de tous les lieux, de leurs strates accumulées comme une conscience en acte, complexe et tissée de réseaux, qui n’appartient à personne et est partagée par tous. Cette accumulation organise le jeu des perspectives multiples qui instaurent l’acte de lecture et sont instaurées par lui. À cet égard, lire constitue ici une physique des oubliés.Richard Powers’ novel Operation Wandering

Kitchenette: Hell or Home? Different"Kitchenette"Images Created by Richard Wright and Gwendolyn Brooks%Kitchenette:Hell or Home?Different"Kitchenette"Images Created by Richard Wright and Gwendolyn Brooks

Institute of Scientific and Technical Information of China (English)

肖志宏

2017-01-01

How the southern black migrants navigate and survive the northern urban space is a question profoundly explored and realistically documented in many migration narratives in African American literature. This paper concentrates on the image of Chicago"kitchenette"in the works of Richard Wright and Gwendolyn Brooks, in an attempt to demonstrate the different inter-pretations of migrant spaces on the urban landscape.

Astronomical fire: Richard Carrington and the solar flare of 1859.

Science.gov (United States)

Clark, Stuart

2007-09-01

An explosion on the Sun in 1859, serendipitously witnessed by amateur astronomer Richard Carrington, plunged telegraphic communications into chaos and bathed two thirds of the Earth's skies in aurorae. Explaining what happened to the Sun and how it could affect Earth, 93 million miles away, helped change the direction of astronomy. From being concerned principally with charting the stars to aid navigation, astronomers became increasingly concerned with what the celestial objects were, how they behaved and how they might affect life on Earth.

Racial Shame and the Pleasure of Transformation: Richard Rodriguez's Queer Aesthetics of Assimilation

Science.gov (United States)

Beltran, Cristina

2012-01-01

This essay analyzes Latino conservative thought by rethinking the logics of assimilation through a simultaneous exploration of aesthetic possibility and negative affect. Focusing on the writings of Richard Rodriguez, the essay considers how creative forms of self-individuation and political agency cannot easily be decoupled from negative forms of…

La paradoja de lo público en Richard Rorty

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Martha Palacio Avendaño

2008-01-01

Full Text Available El concepto de lo público en Richard Rorty, heredero de la tradición liberal, admite ser tratado como parte de un juego del lenguaje denominado liberalismo democrático. En ese sentido, una de las reglas de este juego para saber si una jugada es válida consiste en asumir la distinción entre esfera pública y privada. Richard Rorty pensó que este juego no requería fundamentación más allá de la forma de jugarlo, que el criterio en que se apoyaría estaba en las prácticas que tienen lugar dentro del mismo con arreglo a sostener una utopía que permitiera hacer cada vez más jugadas. Esto es, el liberalismo democrático no requería basarse en algo más allá de las prácticas conducentes a lograr una esperanza social alentada por la libertad en defensa del pluralismo. Su utopía liberal, guiada por el principio de la no-crueldad, haría posible una sociedad inclusiva en la que todos tuvieran espacio para su léxico privado. De este modo, Rorty habría vinculado libertad y solidaridad, pero su juego del lenguaje permite advertir la paradoja del vínculo que implicaría el sentido de lo público. Aquí, la libertad no es condición suficiente de la solidaridad, de modo que la inclusión social no tiene cabida en su juego del lenguaje.

Richard Rorty, o la posibilidad de un etnocentrismo universal

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Isabel Gamero Cabrera

2010-04-01

Full Text Available En el presente artículo intentaremos comprender y analizar las implicaciones actuales de dos tesis del filósofo estadounidense Richard Rorty en relación con su etnocentrismo: La expansión global del sistema democrático liberal como horizonte de su teoría política y la restricción de las creencias de importancia última a la esfera privada. Compararemos esta teoría con las aportaciones de otros dos autores: una interpretación antropológica de los juegos de lenguaje de Wittgenstein y la democracia radical de Mouffe.

A soil moisture accounting-procedure with a Richards' equation-based soil texture-dependent parameterization

Science.gov (United States)

Given a time series of potential evapotranspiration and rainfall data, there are at least two approaches for estimating vertical percolation rates. One approach involves solving Richards' equation (RE) with a plant uptake model. An alternative approach involves applying a simple soil moisture accoun...

[Sir William Richard Gowers: author of the "bible of neurology"].

Science.gov (United States)

Hirose, Genjiro

2014-11-01

William Richard Gowers is one of the great pioneers in neurology and the author of the well-known neurology textbook, "A Manual of Diseases of the Nervous System." His concepts of neurology are based on meticulously and carefully accumulated knowledge of history, observations, and neurological examinations of patients with various neurological diseases. He is not only a great neurologist but also a great teacher who loves teaching students and physicians through well-prepared lectures. We can glean the essence of the field of neurology through his life story and numerous writings concerning neurological diseases.

Of poetics and possibility: Richard Kearney’s post-metaphysical God

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Yolande Steenkamp

2017-11-01

Full Text Available This article provides an overview of Richard Kearney’s attempt at re-imagining God post-metaphysically. In the context of a continental dialogue on the topic, Kearney has responded to onto-theology with a hermeneutic and phenomenologically informed attempt to rethink God post-metaphysically. This eschatological understanding of God is expounded in the article and is placed in relation to Kearney’s more recent concept of Anatheism. The article closes with a few remarks on what may be gained by Kearney’s work, as well as outlining a few critical questions.

Understanding Richard Wright's "Black Boy": A Student Casebook to Issues, Sources, and Historical Documents.

Science.gov (United States)

Felgar, Robert

In "Black Boy," Richard Wright triumphs over an ugly, racist world by fashioning an inspiring, powerful, beautiful, and fictionalized autobiography. To help students understand and appreciate his story in the cultural, political, racial, social, and literary contexts of its time, this casebook provides primary historical documents,…

Il concetto di medium artistico: Richard Wollheim interprete di Ludwig Wittgenstein

OpenAIRE

Maistrello, Andrea

2016-01-01

The aim of the dissertation is twofold: (i) analyzing the notion (well known by aestheticians, but not so intensively studied) of artistic medium; (ii) showing the relevance of such notion for aesthetics through the examination of some relevant aspects of Richard Wollheim’s philosophy of art, maybe the main figure in Anglo-American philosophy as for considering artistic medium central in art-theorizing. Artistic media, according to Wollheim, can develop only if properly connected to a cultura...

Gamma radiation and radon concentration levels at the radioactive waste repositories 'Richard' and 'Bratrstvi'

International Nuclear Information System (INIS)

Berka, Z.; Sabol, J.; Janu, M.

1998-01-01

Owing to the fact that cosmic rays are shielded off, the photon equivalent dose rates in the corridors of the Richard repository are usually slightly lower than outside. However, in points close to barrels containing radioactive waste, the dose rates can reach values as high as tens of μSv/h. Because of high concentrations of natural radionuclides, the dose rates in the Bratrstvi repository is generally considerably higher, as much as 5 times the normal background value. Radon concentrations exhibit specific time variations which are modified by ventilation. Where ventilation is poor or absent, the radon concentrations are extremely high, viz. up to 30 and 300 kBq/m 3 in the Richard and Bratrstvi repositories, respectively. Personal exposure of workers depend on the total time spent underground and on the ventilation rate. While the contribution from photons can be kept below the relevant limits, the radon-related doses may be significant and even exceed the professional limits if no precautions are taken. (P.A.)

Somaesthetic Training, Aesthetics, Ethics, and the Politics of Difference in Richard Shusterman's "Body Consciousness"

Science.gov (United States)

Powell, Kimberly

2010-01-01

In this essay, the author first addresses the theme of disciplined somatic training and its relationship to self-awareness and transformation. Her attention is focused specifically on the chapter on Ludwig Wittgenstein, in which Richard Shusterman presents and then elaborates upon the philosopher's connections between conscious bodily feelings and…

Richard III in Russian Theatre at the Twilight of the "Thaw"

OpenAIRE

Sokolyansky, Mark

2007-01-01

Richard III was very rarely staged in Russian theatre in tsarist and Stalin’s times, because the story of inhuman tyranny provoked associations with Russian political reality. In the period of the so-called “Thaw” (1954ß1964) the play became very popular in the USSR and several scenic productions of it were real events in Russian (and Soviet) theatrical life. In the essay three most original and successful performances (in Kujbyshev, Gorkij and Erevan) are discussed and compare...

Metaforos populiarojo mokslo literatūroje: Richard Dawkins knygos analizė

OpenAIRE

Urbanavičiūtė, Dovilė

2017-01-01

The following paper discusses metaphor usage in the genre of popular science. The object of this analysis is a chapter called ‘Immortal coils’ taken from Richard Dawkins’ book The Selfish Gene. The study discusses the impact of creative conceptual metaphors on the construction of the overall meaning of the text, as well as the significance of their linguistic manifestations and context. In focusing on the genre of popular science, it also makes an attempt at defining potential difficulties of...

Free as in Freedom Richard Stallman's Crusade for Free Software

CERN Document Server

Williams, Sam

2011-01-01

Free as in Freedom interweaves biographical snapshots of GNU project founder Richard Stallman with the political, social and economic history of the free software movement. It examines Stallman's unique personality and how that personality has been at turns a driving force and a drawback in terms of the movement's overall success. Free as in Freedom examines one man's 20-year attempt to codify and communicate the ethics of 1970s era "hacking" culture in such a way that later generations might easily share and build upon the knowledge of their computing forebears. The book documents Stallman'

Naturalismo e existencialismo na teoria moral de Richard Hare

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Marco Antônio Oliveira de Azevedo

2009-08-01

Full Text Available http://dx.doi.org/10.5007/1677-2954.2009v8n2p247 Em um artigo de 1966, Amartya Sen procurou mostrar que mesmo Richard Hare, um devoto explícitodo antinaturalismo em ética, ainda que inadvertidamente, incorreu num tipo de naturalismo que Senintitulou de existencial. Neste breve artigo, traço um resumo dessa crítica à teoria de Hare, em especial,da chamada “Lei de Hume”, a qual Sen preferiu apropriadamente intitular “Regra de Hare”. Pretendomostrar como esse tipo peculiar de “existencialismo” nos conduz, ainda que sob o possível protesto deHare e seus seguidores, a conclusões subjetivistas e relativistas sobre a moralidade.

Richard Swedberg, The Art of Social Theory

DEFF Research Database (Denmark)

Carleheden, Mikael

2015-01-01

to systematic consideration. Swedberg attributes this strange absence to what he sees as the miserable state of contemporary social theory. We must, he claims, avoid two misconceptions: ‘empiricism’ and ‘abstract theory’. In the first case, theory is reduced to the task of summarizing the outcome of empirical......It is a rare event when a new general field of research opens up within sociology. However, with this book, Richard Swedberg intends to do just that. It is not just another book on social theory. It is a book on ‘theorizing’. And that makes all the difference. Swedberg has chosen the term ‘art......’, but also ‘craft’, to emphasize the practical side of doing theory. This topic has been strangely absent, not just in sociology but in the social sciences in general. In order to see this absence, we should ask ourselves how education in sociology is conventionally organized. The answer is by a taken...

Missing Kettles and Too Few Toasters: The Forecasting Methodology at Morphy Richards

OpenAIRE

Lane, D; Hughes, D

2002-01-01

Faced with problems in forecasting at Morphy Richards, this research represents an investigation into their forecasting methodology following the hypothesis that the current forecasting system was no longer sufficient to ensure guaranteed supply to customers, or to enable forward planning.\\ud \\ud The purpose of the research was to identify any requirements for change within the forecasting system and to identify the ‘best practice’ within the industry. Primary research was carried out using a...

The 1D Richards' equation in two layered soils: a Filippov approach to treat discontinuities

Science.gov (United States)

Berardi, Marco; Difonzo, Fabio; Vurro, Michele; Lopez, Luciano

2018-05-01

The infiltration process into the soil is generally modeled by the Richards' partial differential equation (PDE). In this paper a new approach for modeling the infiltration process through the interface of two different soils is proposed, where the interface is seen as a discontinuity surface defined by suitable state variables. Thus, the original 1D Richards' PDE, enriched by a particular choice of the boundary conditions, is first approximated by means of a time semidiscretization, that is by means of the transversal method of lines (TMOL). In such a way a sequence of discontinuous initial value problems, described by a sequence of second order differential systems in the space variable, is derived. Then, Filippov theory on discontinuous dynamical systems may be applied in order to study the relevant dynamics of the problem. The numerical integration of the semidiscretized differential system will be performed by using a one-step method, which employs an event driven procedure to locate the discontinuity surface and to adequately change the vector field.

Richard Murphy: a life in writing

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E. Meihuizen

2006-07-01

Full Text Available The Irish poet Richard Murphy published his autobiography “The kick: a life among writers” in 2003. From a slightly different perspective the subtitle of this work could be rewritten as “A life in writing” since it is an account of the agencies that moulded a life devoted to creative writing which forms the book’s essential impetus. The memoir is based on notebooks which Murphy kept throughout his life “to hold the scraps of verse, elusive images, dreams, desires and revelations” to be developed into poetry. Apart from contextualising his poetry by registering the relationships, circumstances and landscapes from which it germinated, Murphy also tells of the creative process itself and the personal poetics underlying this process. This article explores what is regarded as the central determining feature of Murphy’s identity as poet, namely the relationship between the creative self and a particular place, where the concept of “place” is seen as a cultural palimpsest which represents not only physical qualities, but also the shaping and development of the landscape through time according to a certain way of life.

Book Review of Relational Patterns, Therapeutic Presence: Concepts and practice of Integrative Psychotherapy by Richard G. Erskine

OpenAIRE

Marye O'Reilly-Knapp

2015-01-01

Book Review of Relational Patterns, Therapeutic Presence: Concepts and practice of Integrative Psychotherapy by Richard G. Erskine. Published by Karnac Books: London, 2015 Paperback, Pages 366, ISBN 13: 978-1-78220-190-8

Astronaut Richard H. Truly in training session RMS for STS-2 bldg 9A

Science.gov (United States)

1981-01-01

Astronaut Richard H. Truly in training session with the Remote Manipulator System (RMS) for STS-2 bldg 9A. Views show Truly working at the command console while watching out the windows. Karen Ehlers, an RMS procedures specialist, can be seen at left side of frame (34314); view from behind Truly as he trains at the RMS console (34315).

X-ray cross-sections and crossroads (The International Radiation Physics Society) - Richard Pratt's contributions to both

International Nuclear Information System (INIS)

Hubbell, J.H.

2000-01-01

Some examples of the impact of the theoretical contributions by Richard Pratt and his collaborators on photon cross section compilations at NBS/NIST and elsewhere over the past several decades are presented. Both the theoretical and measurement works which combine to provide this data base, and the contact with the varied user groups in medical applications, nuclear engineering, crystallography and X-ray astronomy, have formed a global crossroads of researchers now embodied in the International Radiation Physics Society (IRPS). Since the founding of the IRPS at the 3 rd International Symposium on Radiation Physics (ISRP-3) in Ferrara, Italy, in 1985, the Secretariat for this 'global radiation physics family' (the IRPS) has resided at the University of Pittsburgh under the direction of Richard Pratt. A brief account of the origins and history of the IRPS, beginning with ISRP-1 in Calcutta in 1974, is presented.

X-ray cross-sections and crossroads (The International Radiation Physics Society) - Richard Pratt's contributions to both

Science.gov (United States)

Hubbell, J. H.

2000-08-01

Some examples of the impact of the theoretical contributions by Richard Pratt and his collaborators on photon cross section compilations at NBS/NIST and elsewhere over the past several decades are presented. Both the theoretical and measurement works which combine to provide this data base, and the contact with the varied user groups in medical applications, nuclear engineering, crystallography and X-ray astronomy, have formed a global crossroads of researchers now embodied in the International Radiation Physics Society (IRPS). Since the founding of the IRPS at the 3rd International Symposium on Radiation Physics (ISRP-3) in Ferrara, Italy, in 1985, the Secretariat for this ``global radiation physics family'' (the IRPS) has resided at the University of Pittsburgh under the direction of Richard Pratt. A brief account of the origins and history of the IRPS, beginning with ISRP-1 in Calcutta in 1974, is presented.

Book Review of Relational Patterns, Therapeutic Presence: Concepts and practice of Integrative Psychotherapy by Richard G. Erskine

Directory of Open Access Journals (Sweden)

Marye O'Reilly-Knapp

2015-12-01

Full Text Available Book Review of Relational Patterns, Therapeutic Presence: Concepts and practice of Integrative Psychotherapy by Richard G. Erskine. Published by Karnac Books: London, 2015 Paperback, Pages 366, ISBN 13: 978-1-78220-190-8

Muusikamaailm : Suur klaveripidu Ruhrimaal. Kissingeni festival tippudega. Sulasoli 80. aastapäev. Richard Rodgers 100 / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2002-01-01

6. juuni-17. augustini Ruhrimaal toimuvast klaverifestivalist. Bad Kissingenis toimuvatest suvepidustustest. Soome Lauljate ja Mängijate Liit tähistab asutamise 80. aastapäeva. Helilooja Richard Rodgersi sünnist möödub 100 aastat

Construction of Fluid - solid Coupling Model with Improved Richards - BP & Its Engineering Application

Science.gov (United States)

Xie, Chengyu; Jia, Nan; Shi, Dongping; Lu, Hao

2017-10-01

In order to study the slurry diffusion law during grouting, Richards unsaturated-saturated model was introduced, the definition of the grouting model is clear, the Richards model control equation was established, And the BP neural network was introduced, the improved fluid-solid coupling model was constructed, Through the use of saturated - unsaturated seepage flow model, As well as the overflow boundary iterative solution of the mixed boundary conditions, the free surface is calculated. Engineering practice for an example, with the aid of multi - field coupling analysis software, the diffusion law of slurry was simulated numerically. The results show that the slurry diffusion rule is affected by grouting material, initial pressure and other factors. When the slurry starts, it flows in the cracks along the upper side of the grouting hole, when the pressure gradient is reduced to the critical pressure, that is, to the lower side of the flow, when the slurry diffusion stability, and ultimately its shape like an 8. The slurry is spread evenly from the overall point of view, from the grouting mouth toward the surrounding evenly spread, it gradually reaches saturation by non-saturation, and it is not a purely saturated flow, when the slurry spread and reach a saturated state, the diffusion time is the engineering grouting time.

Newtonian nudging for a Richards equation-based distributed hydrological model

Science.gov (United States)

Paniconi, Claudio; Marrocu, Marino; Putti, Mario; Verbunt, Mark

The objective of data assimilation is to provide physically consistent estimates of spatially distributed environmental variables. In this study a relatively simple data assimilation method has been implemented in a relatively complex hydrological model. The data assimilation technique is Newtonian relaxation or nudging, in which model variables are driven towards observations by a forcing term added to the model equations. The forcing term is proportional to the difference between simulation and observation (relaxation component) and contains four-dimensional weighting functions that can incorporate prior knowledge about the spatial and temporal variability and characteristic scales of the state variable(s) being assimilated. The numerical model couples a three-dimensional finite element Richards equation solver for variably saturated porous media and a finite difference diffusion wave approximation based on digital elevation data for surface water dynamics. We describe the implementation of the data assimilation algorithm for the coupled model and report on the numerical and hydrological performance of the resulting assimilation scheme. Nudging is shown to be successful in improving the hydrological simulation results, and it introduces little computational cost, in terms of CPU and other numerical aspects of the model's behavior, in some cases even improving numerical performance compared to model runs without nudging. We also examine the sensitivity of the model to nudging term parameters including the spatio-temporal influence coefficients in the weighting functions. Overall the nudging algorithm is quite flexible, for instance in dealing with concurrent observation datasets, gridded or scattered data, and different state variables, and the implementation presented here can be readily extended to any of these features not already incorporated. Moreover the nudging code and tests can serve as a basis for implementation of more sophisticated data assimilation

Richard Rufus's theory of mixture: a medieval explanation of chemical combination.

Science.gov (United States)

Weisberg, Michael; Wood, Rega

2003-05-01

Richard Rufus of Cornwall offered a novel solution to the problem of mixture raised by Aristotle. The puzzle is that mixts or mixed bodies (blood, flesh, wood, etc.) seem to be unexplainable through logic, even though the world is full of them. Rufus's contribution to this long-standing theoretical debate is the development of a modal interpretation of certain Averroistic doctrines. Rufus's account, which posits that the elemental forms in a mixt are in accidental potential, avoids many of the problems that plagued non-atomistic medieval theories of mixture. This paper is an initial examination of Rufus' account.

Süüme sundis vabrikujuhti palgatööliseks jääma / Richard Mutso ; interv. Jüri Saar

Index Scriptorium Estoniae

Mutso, Richard, 1933-

2003-01-01

Intervjuu Võru mööblitehase Wermo peadirektorina töötanud, praeguse tehase nõukogu liikme Richard Mutsoga tehase juhtimisest, euroreferendumist, eraelust. Kommenteerivad: Silva Mutso, Veljo Ipits

Richard Wright's Thematic Treatment of Women in "Uncle Tom's Children,""Black Boy," and "Native Son."

Science.gov (United States)

Brewton, Butler E.

Richard Wright's literary work emphasizes a contrast between black women and white women. Although both are "givers" to black boys, the nature of what they give is different. The black woman gives physical life, feeds it, and protects it at the expense of spiritual or creative vitality. Her goal is to survive bodily, to breathe, to have…

Pimping climate change: Richard Branson, global warming, and the performance of green capitalism

OpenAIRE

Scott Prudham

2009-01-01

On 21 September 2006 UK über-entrepreneur and Virgin Group Chairman Richard Branson pledged approximately £1.6 billion, the equivalent of all the profits from Virgin Atlantic and Virgin Trains for the next ten years, to fighting climate change. Since then, Branson has restated his commitment to action on global warming, including investment in technologies for sequestering carbon dioxide from the atmosphere. In this paper, I critically examine and engage with Branson’s announcements as a spec...

Selfish memes: An update of Richard Dawkins’ bibliometric analysis of key papers in sociobiology

OpenAIRE

Aaen-Stockdale, Craig

2017-01-01

This is an Open Access journal available from http://www.mdpi.com/ In the second edition of The Selfish Gene, Richard Dawkins included a short bibliometric analysis of key papers instrumental to the sociobiological revolution, the intention of which was to support his proposal that ideas spread within a population in an epidemiological manner. In his analysis, Dawkins primarily discussed the influence of an article by British evolutionary biologist William Donald Hamilton which had introdu...

Nothing Risked, Nothing Gained: Richard Powers' Gain and the Horizon of Risk

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Aaron Jaffe

2010-02-01

Full Text Available Cet article interprète Gain, sixième roman de Richard Powers, à la lumière du concept de « seconde modernité » proposé par le sociologue allemand Ulrich Beck. Ce concept souligne la dissémination du risque et la manière dont celle-ci invalide les marchés conclus par la « première modernité » entre l’avenir et le présent, entre l’intérieur du corps et l’extérieur. Cet article entend montrer que Beck fournit un cadre interprétatif utile à la compréhension de ces rapports, hors des impasses catégorielles que suscite l’opposition entre les deux régimes narratifs à l’œuvre dans le texte : le récit biographique, local et individuel, de la maladie de Laura Rowen Bodey, et l’histoire collective de l’entreprise Clare devenue conglomérat.This essay interprets Richard Powers' sixth novel Gain with reference to the German sociologist Ulrich Beck's concept of “second modernity.” The concept underscores the dispersal of risk and how it shreds promissory notes understood in “first modernity” between the future and present and the insides and outsides of the body. It argues that Beck supplies an apt interpretive framework for understanding these relationships and overcoming the categorical impasses between the two narrative words at work in Power's novel, the biographical situatedness of Laura Rowen Bodey's illness and the corporate history of the Clare conglomerate.

Richards Bay Mesometeorological Data – Vertical profiles of air temperature and wind velocity and surface wind statistics.

CSIR Research Space (South Africa)

Scholtz, MT

1978-03-01

Full Text Available This report details the experimental methods and data obtained in the course of a study of the movement of stable air over a complex region. The field work was carried out in the Richards Bay area on the Natal Coast during the period May to August...

Popular science - common ground. A literary critique of Richard Dawkins's The Selfish Gene

OpenAIRE

Nilsen, Helene

2012-01-01

This thesis aims to perform a literary reading of Richard Dawkins's The Selfish Gene from a perspective situated outside of the 'battle of the two cultures'. Chapter 1 takes Foucault's article What is an author?" as its point of departure. After discussing how Dawkins may be seen as a reader of Darwin, I will go on to discuss Foucault's concept of the author-function, before I move on to consider some different readings of and approaches to The Selfish Gene. With reference to a polemic bet...

The effects of coal dust on photosynthetic performance of the mangrove, Avicennia marina in Richards Bay, South Africa

International Nuclear Information System (INIS)

Naidoo, G.; Chirkoot, D.

2004-01-01

Richards Bay, on the northern KwaZulu-Natal coast, is the largest coal exporting port in South Africa. The coal is stored at the Richards Bay Coal Terminal (RBCT) prior to export. Dust from coal operations is a major problem in the Richards Bay area. In this study, we tested the hypothesis that coal dust adversely affects photosynthetic performance of Avicennia marina (Forssk.) Vierh., the dominant mangrove species in the harbour. Photosynthetic performance was determined on 10 trees by measuring carbon dioxide uptake and chlorophyll fluorescence parameters at two elevation sites and on upper and lower leaf surfaces that were covered or uncovered with coal dust. Measurements were made on five clear, sunny days at saturating light (>1000 μmol m -2 s -1 ) and high temperature (28-30 deg. C). Coal dust significantly reduced carbon dioxide exchange of upper and lower leaf surfaces by 17-39%, the reduction being generally greater on the lower leaf surface that is covered by a dense mat of trichomes and salt glands. The reduction in carbon dioxide exchange by coal dust was higher at the high elevation site that supported isolated dwarfed trees. The chlorophyll fluorescence data indicated that leaves coated with dust exhibited significantly lower photosystem II (PS II) quantum yield, lower electron transport rate (ETR) through PSII and reduced quantum efficiency of PSII (F v F m ). The chlorophyll fluorescence data supported the gas exchange measurements and are consistent with reduced photosynthetic performance of leaves coated with coal dust. - Coal dust reduced photosynthetic performance of the mangrove, Avicennia marina

Marie-Christine Agosto. Richard Brautigan. Les fleurs de néant.

Directory of Open Access Journals (Sweden)

Jean-Bernard Basse

2006-04-01

Full Text Available Richard Brautigan, si on lui reconnaît un certain humour, est souvent associé avec condescendance au phénomène hippy et considéré comme un auteur démodé, superficiel. Celui qui écrivait dans Cahier d’un Retour de Troie : « Les mots sont des fleurs de néant » est pourtant l’un de ces écrivains que l’on pourrait qualifier de mineurs essentiels, et seuls ceux qui l’ont peu ou mal lu s’étonneront de ce que Marie-Christine Agosto ait choisi de donner comme sous-titre « Les fleurs de néant » au pet...

Transcendence, Taxis, Trust: Richard Kearney and Jacques Derrida

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Ulrich Schmiedel

2017-03-01

Full Text Available Whatever else it takes to drive a taxi, it takes trust. Day after day, the driver has to decide whether the other is or is not trustworthy. I take the taxi as a test case to analyze and assess Richard Kearney’s diacritical hermeneutics of the other. I argue that Kearney functionalizes the concept of transcendence in order to connect the transcendence of the finite other to the transcendence of the infinite other. However, in his central critique of the deconstructionists following Jacques Derrida, Kearney counters his connection. While Kearney’s critique of Derrida’s account of absolute alterity is correct and compelling, I argue that Derrida’s critique of a distinction between the trustworthy other and the non-trustworthy other might be more crucial than Kearney contends. Insisting on openness to the other’s otherness, Derrida provokes any hermeneutic of the other to trust in transcendence. The taxi is taken as a test to illustrate the implications which diacritical and deconstructive drivers might have for evaluating the entanglement of ethics and eschatology—inside and outside the taxi.

Richard J. Bernstein on Ethics and Philosophy between the Linguistic and the Pragmatic Turn

OpenAIRE

Marchetti, Sarin

2017-01-01

1. In his compelling article American Pragmatism: The Conflict of Narratives, Richard Bernstein quotes a perceptive line by Alasdair MacIntyre that goes [A] tradition not only embodies the narrative of an argument, but is only recovered by an argumentative retelling of that narrative which will itself be in conflict with other argumentative retellings. Bernstein, in the essay mentioned, works through MacIntyre’s passage in order to “engage in the ‘argumentative retelling’ of a metanarrative –...

Diagnosis and treatment of polycystic ovary syndrome (PCOS): an interview with Richard Legro.

Science.gov (United States)

Legro, Richard

2015-03-27

In this podcast, we talk to Professor Richard Legro about the recommendations for the diagnosis and treatment of polycystic ovary syndrome (PCOS) based on clinical practice guidelines and discuss the challenges of diagnosis PCOS at specific age groups. The controversies associated with treatment of PCOS, including therapies for infertility as this is a problem commonly observed in PCOS subjects, are highlighted together with future directions on the topic. The podcast for this interview is available at. http://www.biomedcentral.com/content/supplementary/s12916-015-0299-2-s1.mp3.

Richard J. Hill, Picturing Scotland through the Waverley Novels: Walter Scott and the Origins of the Victorian Illustrated Novel.

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Jacqueline Irene Cannata

2012-10-01

Full Text Available Richard J. Hill, Picturing Scotland through the Waverley Novels: Walter Scott and the Origins of the Victorian Illustrated Novel . Farnham, Surrey, and Burlington, VT: Ashgate, 2010. Pp. 236. ISBN 978-0-7546-6806-0. US$99.99.

Dr. Richard J. Whelan: Seeing the Field of Emotional and Behavior Disorders through the Lens of a Pioneer

Science.gov (United States)

Kaff, Marilyn S.; Teagarden, Jim; Zabel, Robert H.

2011-01-01

Dr. Richard J. Whelan is a distinguished professor emeritus at the University of Kansas. His earliest professional experiences were at the Children's Hospital (Southard School) of the Menninger Clinic, where he served as a recreational therapist, teacher, and director of education. During his career at the University of Kansas and the KU Medical…

Richards growth model and viability indicators for populations subject to interventions

Directory of Open Access Journals (Sweden)

Selene Loibel

2010-12-01

Full Text Available In this work we study the problem of modeling identification of a population employing a discrete dynamic model based on the Richards growth model. The population is subjected to interventions due to consumption, such as hunting or farming animals. The model identification allows us to estimate the probability or the average time for a population number to reach a certain level. The parameter inference for these models are obtained with the use of the likelihood profile technique as developed in this paper. The identification method here developed can be applied to evaluate the productivity of animal husbandry or to evaluate the risk of extinction of autochthon populations. It is applied to data of the Brazilian beef cattle herd population, and the the population number to reach a certain goal level is investigated.Neste trabalho estudamos o problema de identificação do modelo de uma população utilizando um modelo dinâmico discreto baseado no modelo de crescimento de Richards. A população é submetida a intervenções devido ao consumo, como no caso de caça ou na criação de animais. A identificação do modelo permite-nos estimar a probabilidade ou o tempo médio de ocorrência para que se atinja um certo número populacional. A inferência paramétrica dos modelos é obtida através da técnica de perfil de máxima verossimilhança como desenvolvida neste trabalho. O método de identificação desenvolvido pode ser aplicado para avaliar a produtividade de criação animal ou o risco de extinção de uma população autóctone. Ele foi aplicado aos dados da população global de gado de corte bovino brasileiro, e é utilizado na investigação de a população atingir um certo número desejado de cabeças.

Richard Murphy: Autobiography and the Connemara landscape

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Elsa Meihuizen

2015-08-01

Full Text Available It could be argued that an important feature of Richard Murphy’s work, and of his identity as a poet is the relationship between the creative self and a particular place, where ‘place’ should be understood as referring not just to physical qualities of the natural environment, but in a broader sense to denote an environment in which everything is interrelated and connected, and in which there is no sharp division between the natural and the human. The landscape providing inspiration for Murphy’s poetic imagination is the landscapes and seascapes of Connemara in north-west Ireland. In 1959 he settled in this environment which was to be his base for the next 20 years and from this period and this location emanated the bulk of his poetic oeuvre. For Murphy committing to a life of writing poetry necessarily means being in the Connemara landscape. Returning to this environment in adulthood represents a quest for recovering childhood feelings, of belonging and love, as connected to particular places. Murphy’s Connemara poems could be read as an account of this process of re-placement, as a type of autobiographical text in which the artist creates a ‘double portrait’: in writing about the landscape he also writes about himself, creating a place-portrait which is, at the same time, a self-portrait.

Lucien Cuénot, Richard Goldschmidt y Miquel Crusafont Pairó

Directory of Open Access Journals (Sweden)

Casinos, Adrià

2016-06-01

Full Text Available An unpublished text, corresponding to a communication done by Crusafont Pairó is analysed. The communication is strongly critical with Cuénot’s necrology published previously by Goldschmidt, where he regrets the teleological ideas on evolution that Cuénot maintained in the last years of his life.Se analiza un texto inédito de Miquel Crusafont Pairó, correspondiente a comunicación que llevó a cabo en la Fundació Bosch i Cardellach, sobre la necrológica de Lucien Cuénot publicada por Richard Goldschmidt. La comunicación es un fuerte ataque a Goldschmidt por sus críticas a la deriva teleológica de Cuénot en los últimos años de su vida.

Why Was General Richard O’Connor’s Command in Northwest Europe Less Effective Than Expected?

Science.gov (United States)

2011-03-01

Commander of 7 Division and Military Governor of Jerusalem , September 1938- August 1939. ______. Papers of General Sir Richard O’Connor KT, GCB, DSO, MC...Montgomery, Brian. A Field Marshall in the Family: A Personal Biography of Montgomery of Alamein. New York: Taplinger, 1973. Montgomery, Field...Commanders: A Composite Biography . Combat Studies Institute publications, Fort Leavenworth, Kansas: U.S. Army Command and General Staff College, 1989

Símbolo y forma: los hermanos Grimm en Richard Wagner

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Miguel Salmerón Infante

2015-05-01

Full Text Available Este escrito estudia el cómo y el porqué de la presencia de los Cuentos de los Hermanos Grimm en la obra de Richard Wagner. Para dar un enfoque más concreto a esta reflexión el análisis se centra en Sigfrido, el drama musical de Wagner con más atmósfera de cuento, y las influencias y préstamos temáticos, formales y lingüísticos que le aportan los KHM. El artículo entiende que hay dos elementos que aprovecha Wagner de los Grimm para sus dramas musicales. El símbolo para su proyecto de tejido de la identidad alemana. Y la forma del cuento con sus temas y fórmulas recurrentes que el aplicó a su música y muy concretamente al Leitmotiv. Todo ello sin olvidar la muy frecuente presencia de la figura del huérfano tanto en Wagner como en los Grimm.  

Leachate flow around a well in MSW landfill: Analysis of field tests using Richards model.

Science.gov (United States)

Slimani, R; Oxarango, L; Sbartai, B; Tinet, A-J; Olivier, F; Dias, D

2017-05-01

During the lifespan of a Municipal Solid Waste landfill, its leachate drainage system may get clogged. Then, as a consequence of rainfall, leachate generation and possibly leachate injection, the moisture content in the landfill increases to the point that a leachate mound could be created. Therefore, pumping the leachate becomes a necessary solution. This paper presents an original analysis of leachate pumping and injection in an instrumented well. The water table level around the well is monitored by nine piezometers which allow the leachate flow behaviour to be captured. A numerical model based on Richards equation and an exponential relationship between saturated hydraulic conductivity and depth is used to analyze the landfill response to pumping and injection. Decreasing permeability with depth appears to have a major influence on the behaviour of the leachate flow. It could have a drastic negative impact on the pumping efficiency with a maximum quasi-stationary pumping rate limited to approximately 1m 3 /h for the tested well and the radius of influence is less than 20m. The numerical model provides a reasonable description of both pumping and injection tests. However, an anomalous behaviour observed at the transition between pumping and recovery phases is observed. This could be due to a limitation of the Richards model in that it neglects the gas phase behaviour and other double porosity heterogeneous effects. Copyright © 2016 Elsevier Ltd. All rights reserved.

An experimental ‘Life’ for an experimental life : Richard Waller's biography of Robert Hooke (1705)

OpenAIRE

Moxham, Noah

2016-01-01

Richard Waller's ‘Life of Dr Robert Hooke’, prefixed to his edition of Hooke's Posthumous Works (1705), is an important source for the life of one of the most eminent members of the early Royal Society. It also has the distinction of being one of the earliest biographies of a man of science to be published in English. I argue that it is in fact the first biography to embrace the subject's natural-philosophical work as the centre of his life, and I investigate Waller's reasons for adopting thi...

Exact and grid-free solutions to the Lighthill-Whitham-Richards traffic flow model with bounded acceleration for a class of fundamental diagrams

KAUST Repository

Qiu, Shanwen; Abdelaziz, Mohamed Ewis; Abdel Latif, Fadl Hicham Fadl; Claudel, Christian G.

2013-01-01

In this article, we propose a new exact and grid-free numerical scheme for computing solutions associated with an hybrid traffic flow model based on the Lighthill-Whitham-Richards (LWR) partial differential equation, for a class of fundamental

Harmonic analysis, partial differential equations and applications in honor of Richard L. Wheeden

CERN Document Server

Franchi, Bruno; Lu, Guozhen; Perez, Carlos; Sawyer, Eric

2017-01-01

This is a collection of contributed papers by many eminent Harmonic Analysts and specialists of Partial Differential equations. The papers focus on weighted norm equalities for singular integrals, focusing wave equations, degenerate elliptic equations, Navier-Stokes flow in two dimensions and Poincare-Sobolev inequalities in the setting of metric spaces equipped with measures among others. Many topics considered in this volume stem from the interests of Richard L. Wheeden whose contributions to Potential Theory, singular integral theory and degenerate elliptic PDE theory this volume honors. Luis Caffarelli, Sagun Chanillo, Bruno Franchi, Cristian Guttierez, Xiaojun Huang, Carlos Kenig, Ermanno Lanconelli, Eric Sawyer and Alexander Volberg, are some of the many contributors to this volume. .

Book review: Unholy trinity: The IMF, World Bank and WTO Richard Peet

Directory of Open Access Journals (Sweden)

M Breitenbach

2014-05-01

Full Text Available In this timely book Richard Peet and his team lay the foundation with an excellent analysis of the process of globalisation and the resultant emergence of the global economy. The authors are especially critical of the increasing influence of institutions like the International Monetary Fund (IMF, World Bank and World Trade Organisation (WTO on the economy and the consequences experienced by peoples, cultures and the environment. The single ideology of neo-liberalism is blamed for the undesirable outcomes. This book considers concepts of power, political interest, hegemony, discourse, responsibility and the power of practicality, in critically examining the IMF, World Bank and WTO. The conclusion is reached that “all three institutions play roles greatly different from those originally agreed to under the charters that set them up”.

Richard Wrangham. Catching fire. How cooking made us Human. Basic Books (Perseus Books Group

Directory of Open Access Journals (Sweden)

Claude-Marcel Hladik

2009-11-01

Full Text Available L’histoire de l’émergence de l’homme est remise en cause par cet ouvrage puisque jusqu’à présent la plupart des anthropologues et des paléontologues s’accordaient pour faire remonter à environ 500.000 ans les premières utilisations du feu pour la cuisson des aliments par le genre Homo. Les arguments présentés par Richard Wrangham dans son dernier ouvrage nous font remonter aux deux derniers millions d’années. Wrangham et ses collègues avaient publié, dès 1999, les résultats de fouilles au cou...

Meeting to honor F. Richard Stephenson on his 70th birthday

CERN Document Server

Green, David; Strom, Richard

2015-01-01

This book contains papers from a conference held to celebrate the 70th birthday of one of the world’s foremost astronomical historians, Professor F. Richard Stephenson, the latest recipient of the American Astronomical Society’s highest award for research in astronomical history, the LeRoy Doggett Prize. Reflecting Professor Stephenson’s extensive research portfolio, this book brings together under one cover papers on four different areas of scholarship: applied historical astronomy (which Stephenson founded); Islamic astronomy; Oriental astronomy; and amateur astronomy.  These papers are penned by astronomers from Canada, China, England, France, Georgia, Iran, Japan, Lebanon, the Netherlands, Portugal, Thailand and the USA. Its diverse coverage represents a wide cross-section of the history of astronomy community.  Under discussion are ways in which recent research using historical data has provided new insights into auroral and solar activity, supernovae and changes in the rotation rate of the E...

A critical review of Richard Lynn's reports on reaction time and race.

Science.gov (United States)

Thomas, Drew M

2011-01-01

In the early 1990s, psychologist Richard Lynn published papers documenting average reaction times and decision times in samples of nine-year-olds taken from across the world. After summarizing these data, Lynn interpreted his results as evidence of national and racial differences in decision time and general intelligence. Others have also interpreted Lynn's data as evidence of racial differences in decision time and intelligence. However, comparing Lynn's summaries with his original reports shows that Lynn misreported and omitted some of his own data. Once these errors are fixed the rankings of nations in Lynn's datasets are unstable across different decision time measures. This instability, as well as within-race heterogeneity and between-race overlap in decision times, implies that Lynn's reaction time data do not permit generalizations about the decision times and intelligence of people of different races.

AD-1 with research pilot Richard E. Gray

Science.gov (United States)

1982-01-01

Standing in front of the AD-1 Oblique Wing research aircraft is research pilot Richard E. Gray. Richard E. Gray joined National Aeronautics and Space Administration's Johnson Space Center, Houston, Texas, in November 1978, as an aerospace research pilot. In November 1981, Dick joined the NASA's Ames-Dryden Flight Research Facility, Edwards, California, as a research pilot. Dick was a former Co-op at the NASA Flight Research Center (a previous name of the Ames-Dryden Flight Research Facility), serving as an Operations Engineer. At Ames-Dryden, Dick was a pilot for the F-14 Aileron Rudder Interconnect Program, AD-1 Oblique Wing Research Aircraft, F-8 Digital Fly-By-Wire and Pilot Induced Oscillations investigations. He also flew the F-104, T-37, and the F-15. On November 8, 1982, Gray was fatally injured in a T-37 jet aircraft while making a pilot proficiency flight. Dick graduated with a Bachelors degree in Aeronautical Engineering from San Jose State University in 1969. He joined the U.S. Navy in July 1969, becoming a Naval Aviator in January 1971, when he was assigned to F-4 Phantoms at Naval Air Station (NAS) Miramar, California. In 1972, he flew 48 combat missions in Vietnam in F-4s with VF-111 aboard the USS Coral Sea. After making a second cruise in 1973, Dick was assigned to Air Test and Evaluation Squadron Four (VX-4) at NAS Point Mugu, California, as a project pilot on various operational test and evaluation programs. In November 1978, Dick retired from the Navy and joined NASA's Johnson Space Center. At JSC Gray served as chief project pilot on the WB-57F high-altitude research projects and as the prime television chase pilot in a T-38 for the landing portion of the Space Shuttle orbital flight tests. Dick had over 3,000 hours in more than 30 types of aircraft, an airline transport rating, and 252 carrier arrested landings. He was a member of the Society of Experimental Test Pilots serving on the Board of Directors as Southwest Section Technical Adviser in

Forjando nuestras democracias: entre Richard Rorty y Vladimiro Montesinos

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Miguel Giusti

2001-07-01

Full Text Available This article aims at explaining the recent history of Peru, in an exercise in which it is possible to extract lessons about the way Latin American democracies have been(or have not been forged. The text draws a parallel between the ideas developed by Richard Rorty in his recently published book, Forjar nuestro país. El pensamiento de izquierdas en los Estados Unidos del siglo XX, and the events in Fugimori's and Montesinos' Peru. If, according to what Rorty believes, "national pride is for the countries what self esteem is for individuals ... " how would it be possible to narrate a history in which there are few motives to be proud of? Trying to escape fatalism and sarcasm, the text tries to show that Montesino's political course is, symbolically, a summary of the decomposition process of Peruvian democracy. Secondly, the text analyses the movements of the political left wing and deals with the support the regimen received from inside and outside the country, a support that was largely based on the illusion of political stability. Finally, it states, as Rorty does, that in order to forge democracies it is necessary for us to be deeply committed to the defense of the State of Right.

Richard Arwed Pfeifer - a pioneer of 'medical pedagogy' and an opponent of Paul Schroder.

Science.gov (United States)

Steinberg, Holger; Carius, Dirk; Himmerich, Hubertus

2013-12-01

Richard Arwed Pfeifer (1877-1957) was one of the initiators and foster fathers of the renowned child-psychiatric and special needs education workgroup at Leipzig University under Paul Schröder (1873-1941) in the 1920s and 1930s. This paper is an account of their dispute concerning the interrelations between child and adolescent psychiatry and special needs education, as well as their disagreement about whether adolescent psychopaths should be admitted to specialized child psychiatric wards or elsewhere. Moreover, Pfeifer questioned the practical relevance of the separation of constitutional and environmentally-based psychopathy and fought eugenic research, which he found incompatible with the ethics of his profession as a remedial teacher and child psychiatrist.

PolyRES: A polygon-based Richards equation solver

International Nuclear Information System (INIS)

Hills, R.G.

1995-12-01

This document describes the theory, implementation, and use of a software package designed to solve the transient, two-dimensional, Richards equation for water flow in unsaturated-saturated soils. This package was specifically designed to model complex geometries with minimal input from the user and to simulate groundwater flow related to assessment of low-level radioactive waste disposal sites and engineered facilities. The spatial variation of the hydraulic properties can be defined across individual polygon-shaped subdomains, called objects. These objects combine to form a polygon-shaped model domain. Each object can have its own distribution of hydraulic parameters. The resulting model domain and polygon-shaped internal objects are mapped onto a rectangular, finite-volume, computational grid by a preprocessor. This allows the user to specify model geometry independently of the underlying grid and greatly simplifies user input for complex geometries. In addition, this approach significantly reduces the computational requirements since complex geometries are actually modeled on a rectangular grid. This results in well-structured, finite difference-like systems of equations that require minimal storage and are very efficient to solve. The documentation for this software package includes a user's manual, a detailed description of the underlying theory, and a detailed discussion of program flow. Several example problems are presented that show the use and features of the software package. The water flow predictions for several of these example problems are compared to those of another algorithm to test for prediction equivalency

Ultra-sensitive radionuclide spectrometry. Radiometrics and mass spectrometry synergy

International Nuclear Information System (INIS)

Povinec, P.P.

2005-01-01

Recent developments in radiometrics and mass spectrometry techniques for ultra-sensitive analysis of radionuclides in the marine environment are reviewed. In the radiometrics sector the dominant development has been the utilization of large HPGe detectors in underground laboratories with anti-cosmic or anti-Compton shielding for the analysis of short and medium-lived radionuclides in the environment. In the mass spectrometry sector, applications of inductively coupled plasma mass spectrometry (ICP-MS) and accelerator mass spectrometry (AMS) for the analysis of long-lived radionuclides in the environment are the most important recent achievements. The recent developments do not only considerably decrease the detection limits for several radionuclides (up to several orders of magnitude), but they also enable to decrease sample volumes so that sampling, e.g., of the water column can be much easier and more effective. A comparison of radiometrics and mass spectrometry results for the analysis of radionuclides in the marine environment shows a reasonable agreement - within quoted uncertainties, for wide range of activities and different sample matrices analyzed. (author)

O ateísmo de Richard Dawkins nas fronteiras da ciência evolucionista e do senso comum

OpenAIRE

Franco, Clarissa de

2014-01-01

O objeto de estudo consiste nas principais ideias ateístas de Richard Dawkins e na recepção destas por parte dos ateus inseridos na cultura brasileira. Dawkins é um dos principais divulgadores e militantes do movimento ateísta da atualidade, e a despeito de sua faceta pública divulgada em sites mundiais e em livros de reconhecido sucesso existem debates do autor, concernentes aos espaços acadêmicos e restritos a cientistas, que nem sempre se apresentam congruentes às suas e...

The Mysterious Fall of Soeharto: A Genre Analysis of Richard Mann’s Plots and Schemes that Brought Down Soeharto (PSBDS

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Sugeng Purwanto

2012-12-01

Full Text Available The real cause of Soeharto’s fall from the Indonesian presidency remains a mystery. Richard Mann (1998 launched three significant rhetorical questions: (a Was President Soeharto toppled by student demonstrators and people’s power? (b Was he brought down by the withdrawal of support from the United States? (c Or, was his sudden fall brought about by all of the two plus large doses of Oriental plotting and scheming? This article attempts to analyze Richard Mann’s PSBDS in terms of its macrostructure in order to find out the real cause of Soeharto’s fall. The analysis is substantiated by different resources as linguistic evidences, to justify the validity of the findings. The study revealed a proposition that critical reading is the key to successful comprehension of a text which may include a crosschecking with other resources, a careful identification of the generic structure of a text, and paying attention to how an author positions his or her readers. The article concludes, that in fact, Soeharto resigned from presidency on his own wisdom in order to avoid more bloodshed in Indonesian dreamland.

Reactor gamma spectrometry: status

International Nuclear Information System (INIS)

Gold, R.; Kaiser, B.J.

1979-01-01

Current work is described for Compton Recoil Gamma-Ray Spectrometry including developments in experimental technique as well as recent reactor spectrometry measurements. The current status of the method is described concerning gamma spectromoetry probe design and response characteristics. Emphasis is given to gamma spectrometry work in US LWR and BR programs. Gamma spectrometry in BR environments are outlined by focussing on start-up plans for the Fast Test Reactor (FTR). Gamma spectrometry results are presented for a LWR pressure vessel mockup in the Poolside Critical Assembly (PCA) at Oak Ridge National Laboratory

Femineidad y ficción en la obra operística de Richard Strauss

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María José Sánchez Usón

2014-01-01

Full Text Available Tras la muerte de Wagner y Brahms, Richard Straussemergió como uno de los compositores más importantesy populares de la música del siglo XX. Su trayectoria vitaly profesional, azarosa y turbulenta, al igual que las décadasque vivió, estuvo marcada por la realidad femenina.Es innegable que las mujeres de la vida de Strauss, todasde fuerte y distintiva personalidad, dejaron en él huellastan hondas que fue necesario llevarlas a escena, no sólocomo una aportación valiosa a la tipología caracterológicafemenina, sino también como un ejercicio terapéuticopersonal. Así, mujeres reales y mujeres ficticias se confundenen sus obras en un proceso creativo único: el delhombre-artista.

Arte y política: un estudio comparativo de Jacques Rancière y Nelly Richard para el arte latinoamericano

Directory of Open Access Journals (Sweden)

Verónica Capasso

2016-01-01

Full Text Available En este artículo se indagan y comparan las teorías de Jacques Rancière y Nelly Richard sobre la relación entre arte y política desde el pensamiento posfundacional, y se producen reflexiones y análisis de manifestaciones artísticas latinoamericanas vanguardistas o críticas en diálogo con ambas. Para ello, se parte de una presentación de las teorías de Rancière y Richard en términos generales, se focaliza en las ideas que dichos autores tienen de la política y, específicamente, en la conceptualización que hacen del arte y su relación con la política. Al mismo tiempo, se desarrolla una interpretación de producciones artísticas desde una mirada centrada en sus diversas conexiones con lo político, más allá del contenido temático de estas. Se utiliza la perspectiva metodológica cualitativa transdisciplinaria, que articula distintas áreas de conocimiento (filosofía política, sociología, historia del arte. En el caso de los desarrollos de Jacques Rancière, se recurre a herramientas teóricas metropolitanas para resituarlas y repensarlas en función del arte de Latinoamérica. En este sentido, se trata de potenciar sus ideas en el análisis de casos locales. En cuanto a la teoría de Nelly Richard, sus conceptos de arte crítico y vanguardista se ponen en relación con el arte latinoamericano. Finalmente, se propone una comparación en la cual se destacan similitudes y diferencias conceptuales entre ambos en combinación con análisis de casos para abrir el panorama analítico e interpretativo que vincule teorías actuales con estudios de manifestaciones artísticas locales.

Alpha spectrometry and secondary ion mass spectrometry of thorium

International Nuclear Information System (INIS)

Strisovska, Jana; Kuruc, Jozef; Galanda, Dusan; Matel, Lubomir; Velic, Dusan; Aranyosiova, Monika

2009-01-01

A sample of thorium content on steel discs was prepared by electrodeposition with a view to determining the natural thorium isotope. Thorium was determined by alpha spectrometry and by secondary ion mass spectrometry and the results of the two methods were compared

Accelerator-based ultrasensitive mass spectrometry

International Nuclear Information System (INIS)

Gove, H.E.

1985-01-01

This chapter describes a new mass spectrometry technique involving charged particle accelerators normally used for basic research in nuclear science. Topics considered include the limitations of conventional mass spectrometry, the limitations of the direct measurement of radioactive decay, mass spectrometry using a tandem electrostatic accelerator, mass spectrometry using a cyclotron, how accelerator mass spectrometry circumvents the limitations of conventional mass spectrometry, measurements of stable isotopes, nuclear physics and astrophysics applications, modifications to existing accelerators, descriptions of dedicated systems, and future applications

Methods of neutron spectrometry

International Nuclear Information System (INIS)

Doerschel, B.

1981-01-01

The different methods of neutron spectrometry are based on the direct measurement of neutron velocity or on the use of suitable energy-dependent interaction processes. In the latter case the measuring effect of a detector is connected with the searched neutron spectrum by an integral equation. The solution needs suitable unfolding procedures. The most important methods of neutron spectrometry are the time-of-flight method, the crystal spectrometry, the neutron spectrometry by use of elastic collisions with hydrogen nuclei, and neutron spectrometry with the aid of nuclear reactions, especially of the neutron-induced activation. The advantages and disadvantages of these methods are contrasted considering the resolution, the measurable energy range, the sensitivity, and the experimental and computational efforts. (author)

Perception of Leitmotives in Richard Wagner's Der Ring des Nibelungen

Directory of Open Access Journals (Sweden)

David J. Baker

2017-05-01

Full Text Available The music of Richard Wagner tends to generate very diverse judgments indicative of the complex relationship between listeners and the sophisticated musical structures in Wagner's music. This paper presents findings from two listening experiments using the music from Wagner's Der Ring des Nibelungen that explores musical as well as individual listener parameters to better understand how listeners are able to hear leitmotives, a compositional device closely associated with Wagner's music. Results confirm findings from a previous experiment showing that specific expertise with Wagner's music can account for a greater portion of the variance in an individual's ability to recognize and remember musical material compared to measures of generic musical training. Results also explore how acoustical distance of the leitmotives affects memory recognition using a chroma similarity measure. In addition, we show how characteristics of the compositional structure of the leitmotives contributes to their salience and memorability. A final model is then presented that accounts for the aforementioned individual differences factors, as well as parameters of musical surface and structure. Our results suggest that that future work in music perception may consider both individual differences variables beyond musical training, as well as symbolic features and audio commonly used in music information retrieval in order to build robust models of musical perception and cognition.

The ISS flight of Richard Garriott: a template for medicine and science investigation on future spaceflight participant missions.

Science.gov (United States)

Jennings, Richard T; Garriott, Owen K; Bogomolov, Valery V; Pochuev, Vladimir I; Morgun, Valery V; Garriott, Richard A

2010-02-01

A total of eight commercial spaceflight participants have launched to the International Space Station (ISS) on Soyuz vehicles. Based on an older mean age compared to career astronauts and an increased prevalence of medical conditions, spaceflight participants have provided the opportunity to learn about the effect of space travel on crewmembers with medical problems. The 12-d Soyuz TMA-13/12 ISS flight of spaceflight participant Richard Garriott included medical factors that required preflight intervention, risk mitigation strategies, and provided the opportunity for medical study on-orbit. Equally important, Mr. Garriott conducted extensive medical, scientific, and educational payload operations during the flight. These included 7 medical experiments and a total of 15 scientific projects such as protein crystal growth, Earth observations/photography, educational projects with schools, and amateur radio. The medical studies included the effect of microgravity on immune function, sleep, bone loss, corneal refractive surgery, low back pain, motion perception, and intraocular pressure. The overall mission success resulted from non-bureaucratic agility in mission planning, cooperation with investigators from NASA, ISS, International Partners, and the Korean Aerospace Research Institute, in-flight support and leadership from a team with spaceflight and Capcom experience, and overall mission support from the ISS program. This article focuses on science opportunities that suborbital and orbital spaceflight participant flights offer and suggests that the science program on Richard Garriott's flight be considered a model for future orbital and suborbital missions. The medical challenges are presented in a companion article.

Genetics and the origin of species: the continuing synthesis a symposium in honor of Richard G. Harrison

Science.gov (United States)

Grosberg, Richard K.; Rand, David M.; Normark, Benjamin B.

2013-01-01

This is a special issue of Genetica that has its origins in a symposium held in honor of Richard G. Harrison at Ithaca, New York on July 22–23. Former students of Rick Harrison organized the symposium and most of the speakers were former students, as well. The quality and breadth of the talks were a testament to Rick’s influence as a thinker, synthesizer, and mentor and it is only appropriate to reflect on Rick’s contributions to the fields of evolutionary ecology, systematics, and genetics in this preface to the symposium articles. PMID:21152955

Hamilton on surnud, tema mõju mitte : in memoriam Richard Hamilton (24. II 1922 - 13. IX 2011) / Kadri Karro ; kommenteerinud Eha Komissarov, Sirje Helme, Jaak Kangilaski

Index Scriptorium Estoniae

Karro,Kadri

2011-01-01

Briti kunstniku Richard Hamiltoni (1922 - 2011) loomingust eesti kunstiteadlaste Eha Komissarovi, Sirje Helme ja Jaak Kangilaski pilgu läbi. Lähemalt 1956. aastal valminud kollaažist "Mis teeb tänapäeva kodud nii eriliseks, nii meeldivaks?"

Destruction of the Phoenix/Hibiscus and Barringtonia racemosa Communities at Richards Bay, Natal, South Africa

Directory of Open Access Journals (Sweden)

P. J. Weisser

1982-10-01

Full Text Available The destruction of the Phoenix!Hibiscus and Barringtonia racemosa Communities described by Venter in 1972 on the southern shores of Richards Bay is reported. The cause was the artificial openingof a new mouth about 5,5 km south of the original mouth, which increased tidal range and salinity. These swamp communities occupied a narrow band about 6 ha in area behind the Bruguiera gymnorrhiza Community. An estimated 95 % of the communities was affected and only on the landward border were some isolated remnants of species such as Acrostichum aureum, Hibiscus tiliaceus and Phoenix reclinata detected .Young stands of  Phragmites australis, seedlings of  Bruguiera gymnorrhiza and Avicennia marina and epipelic algae are recoIonizing the affected area.

BACK TO THE ORIGINS OF THE REPUDIATION OF WUNDT: OSWALD KÜLPE AND RICHARD AVENARIUS.

Science.gov (United States)

Russo Krauss, Chiara

2017-01-01

This essay provides a fresh account of the break between Oswald Külpe and his master Wilhelm Wundt. Kurt Danziger's reconstruction of the "repudiation" of Wundt, which has become the canon for this significant episode of history of psychology, focused on the supposed influence of Ernst Mach on this set of events, overshadowing the other exponent of Empiriocriticism: Richard Avenarius. Analyzing archival documents and examining anew the primary sources, the paper shows that Avenarius was himself a member of Wundt's circle, and that his "repudiation" of the master paved the way for Külpe. The essay points out the original anti-Wundtian aspects of Avenarius' notion of psychology, thus showing how they were then adopted by Külpe. © 2016 Wiley Periodicals, Inc.

Atomic mass spectrometry

International Nuclear Information System (INIS)

Sanz-Medel, A.

1997-01-01

The elemental inorganic analysis seems to be dominated today by techniques based on atomic spectrometry. After an evaluation of advantages and limitations of using mass analysers (ion detectors) versus conventional photomultipliers (photon detector) a brief review of the more popular techniques of the emerging Atomic Mass spectrometry is carried out. Their huge potential for inorganic trace analysis is such that in the future we could well witness how this end of the century and millennium marked the fall of the photons empire in Analytical Atomic Spectrometry. (Author)

HealthSouth's most wanted. Founder and former chairman and CEO Richard Scrushy is indicted for 85 counts of conspiracy, fraud and money laundering.

Science.gov (United States)

Piotrowski, Julie

2003-11-10

Wake-up call for the industry or an isolated case of corporate chicanery? Healthcare experts are divided on the import of Richard Scrushy's indictment on 85 counts last week in connection with the financial scandal at HealthSouth Corp. The indictment alleges the company founder relied on electronic and telephone surveillance, threats and intimidation to control his accomplices.

“This World Is Not My Home”: Richard Mouw and Christian Nationalism

Directory of Open Access Journals (Sweden)

Aaron Pattillo-Lunt

2016-12-01

Full Text Available American evangelicalism has often been punctuated by dual commitments to the United States and to God. Those commitments were strongest within politically conservative evangelicalism. Though representing a solid majority among professing evangelicals, conservatives could not speak for the movement as a whole. Politically progressive evangelicals, beginning in the 1960s, formed a dissenting opinion of the post-World War II revival of Christian nationalism. They dared to challenge American action abroad, noticeably during the Vietnam War. Their critique of Christian nationalism and conservative evangelicals’ close ties to the Republican Party led them to seek refuge in either progressive policies or the Democratic Party. A third, underexplored subgroup of evangelicalism rooted in reformed theology becomes important to consider in this regard. These reformed evangelicals sought to contextualize nationalism in biblical rather than partisan or political terms. This goal is championed well by Richard Mouw, resulting in a nuanced look at evangelical Christians’ difficult dual role as both citizens of the Kingdom of God and the United States.

Fast neutron spectrometry and dosimetry; Spectrometrie et dosimetrie des neutrons rapides

Energy Technology Data Exchange (ETDEWEB)

Blaize, S; Ailloud, J; Mariani, J; Millot, J P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

We have studied fast neutron spectrometry and dosimetry through the recoil protons they produce in hydrogenated samples. In spectrometric, we used nuclear emulsions, in dosimetric, we used polyethylene coated with zinc sulphide and placed before a photomultiplier. (author)Fren. [French] Nous avons etudie la spectrometrie et la dosimetrie des neutrons rapides en utilisant les protons de recul qu'ils produisent dans une matiere hydrogenee. En spectrometrie, nous avons employe des emulsions nucleaires, en dosimetrie, du polyethylene recouvert de sulfure de zinc place devant un photomultiplicateur. (auteur)

Analytical and grid-free solutions to the Lighthill-Whitham-Richards traffic flow model

KAUST Repository

Mazaré , Pierre Emmanuel; Dehwah, Ahmad H.; Claudel, Christian G.; Bayen, Alexandre M.

2011-01-01

In this article, we propose a computational method for solving the Lighthill-Whitham-Richards (LWR) partial differential equation (PDE) semi-analytically for arbitrary piecewise-constant initial and boundary conditions, and for arbitrary concave fundamental diagrams. With these assumptions, we show that the solution to the LWR PDE at any location and time can be computed exactly and semi-analytically for a very low computational cost using the cumulative number of vehicles formulation of the problem. We implement the proposed computational method on a representative traffic flow scenario to illustrate the exactness of the analytical solution. We also show that the proposed scheme can handle more complex scenarios including traffic lights or moving bottlenecks. The computational cost of the method is very favorable, and is compared with existing algorithms. A toolbox implementation available for public download is briefly described, and posted at http://traffic.berkeley.edu/project/downloads/lwrsolver. © 2011 Elsevier Ltd.

Analytical and grid-free solutions to the Lighthill-Whitham-Richards traffic flow model

KAUST Repository

Mazaré, Pierre Emmanuel

2011-12-01

In this article, we propose a computational method for solving the Lighthill-Whitham-Richards (LWR) partial differential equation (PDE) semi-analytically for arbitrary piecewise-constant initial and boundary conditions, and for arbitrary concave fundamental diagrams. With these assumptions, we show that the solution to the LWR PDE at any location and time can be computed exactly and semi-analytically for a very low computational cost using the cumulative number of vehicles formulation of the problem. We implement the proposed computational method on a representative traffic flow scenario to illustrate the exactness of the analytical solution. We also show that the proposed scheme can handle more complex scenarios including traffic lights or moving bottlenecks. The computational cost of the method is very favorable, and is compared with existing algorithms. A toolbox implementation available for public download is briefly described, and posted at http://traffic.berkeley.edu/project/downloads/lwrsolver. © 2011 Elsevier Ltd.

Cluster secondary ion mass spectrometry microscope mode mass spectrometry imaging.

Science.gov (United States)

Kiss, András; Smith, Donald F; Jungmann, Julia H; Heeren, Ron M A

2013-12-30

Microscope mode imaging for secondary ion mass spectrometry is a technique with the promise of simultaneous high spatial resolution and high-speed imaging of biomolecules from complex surfaces. Technological developments such as new position-sensitive detectors, in combination with polyatomic primary ion sources, are required to exploit the full potential of microscope mode mass spectrometry imaging, i.e. to efficiently push the limits of ultra-high spatial resolution, sample throughput and sensitivity. In this work, a C60 primary source was combined with a commercial mass microscope for microscope mode secondary ion mass spectrometry imaging. The detector setup is a pixelated detector from the Medipix/Timepix family with high-voltage post-acceleration capabilities. The system's mass spectral and imaging performance is tested with various benchmark samples and thin tissue sections. The high secondary ion yield (with respect to 'traditional' monatomic primary ion sources) of the C60 primary ion source and the increased sensitivity of the high voltage detector setup improve microscope mode secondary ion mass spectrometry imaging. The analysis time and the signal-to-noise ratio are improved compared with other microscope mode imaging systems, all at high spatial resolution. We have demonstrated the unique capabilities of a C60 ion microscope with a Timepix detector for high spatial resolution microscope mode secondary ion mass spectrometry imaging. Copyright © 2013 John Wiley & Sons, Ltd.

Je suis un zombie : Études récentes sur Richard Matheson et le mort-vivant

OpenAIRE

Ransom, Amy J.; Trudel, Jean-Louis

2013-01-01

Dans ce texte nous résumons quatre essais récents sur le phénomène actuel du zombie ainsi qu’un collectif sur l’œuvre de Richard Matheson dont la première version filmique du roman Je suis une légende a servi d’inspiration à l’ur-film de zombies, La nuit des morts vivants de George A. Romero. Tandis que Pierre Cassou-Noguès et Maxime Coulombe signent des traitements plus philosophiques du zombie, leurs ouvrages diffèrent beaucoup dans leur forme et leur fonction. Pour leur part, Amélie Pépin ...

[Richard Koch's life in national socialism and in Soviet emigration].

Science.gov (United States)

Boltres, Daniela; Töpfer, Frank; Wiesing, Urban

2006-01-01

The Jewish historian and theorist of medicine, Richard Koch, teaching in Frankfurt/Main, fled in 1936 from National Socialist Germany to the USSR where he lived in the Caucasian spa Essentuki until his death in 1949. Here he worked as a doctor and continued his scientific work, especially on the foundations of medicine in natural philosophy. None of his works of this time were published. Koch was a scientific outsider in the USSR, and he was aware of this. However, he tried to make his views compatible with official doctrines. In 1947 he lost his employment at the medical clinic of Essentuki, and his material situation grew worse. It is still an open question whether this development was related to an increasingly anti-Jewish atmosphere in the USSR that was linked with the Stalinist "purges", as Koch himself appeared to believe. Before his flight from Germany Koch did not show any tendency towards communism or the political left at all. His attitude towards Soviet society and Stalin was mixed: cautious criticism was accompanied by strong expressions of commitment to Stalin and Koch's new Socialist home. The question to what extent Koch's comments showed his true convictions must remain without a definite answer. At least in part they can be understood as precautions in threatening circumstances. The opportunity of a remigration to Germany after 1945, however, was turned down by Koch.

Forensic Mass Spectrometry

Science.gov (United States)

Hoffmann, William D.; Jackson, Glen P.

2015-07-01

Developments in forensic mass spectrometry tend to follow, rather than lead, the developments in other disciplines. Examples of techniques having forensic potential born independently of forensic applications include ambient ionization, imaging mass spectrometry, isotope ratio mass spectrometry, portable mass spectrometers, and hyphenated chromatography-mass spectrometry instruments, to name a few. Forensic science has the potential to benefit enormously from developments that are funded by other means, if only the infrastructure and personnel existed to adopt, validate, and implement the new technologies into casework. Perhaps one unique area in which forensic science is at the cutting edge is in the area of chemometrics and the determination of likelihood ratios for the evaluation of the weight of evidence. Such statistical techniques have been developed most extensively for ignitable-liquid residue analyses and isotope ratio analysis. This review attempts to capture the trends, motivating forces, and likely impact of developing areas of forensic mass spectrometry, with the caveat that none of this research is likely to have any real impact in the forensic community unless: (a) The instruments developed are turned into robust black boxes with red and green lights for positives and negatives, respectively, or (b) there are PhD graduates in the workforce who can help adopt these sophisticated techniques.

Spectrometry techniques for radioactivity measurements

International Nuclear Information System (INIS)

Anilkumar, S.

2016-01-01

The energy of the radiation emission following the nuclear decay is unique and the characteristic of the radio nuclide which undergoes decay. Thus measurement of the energy of the radiation offers a method of identifying the radio nuclides. The prime requirement of the energy measurement is a suitable detector which shows response proportional to the energy of the radiation rather than the presence of the radiation. The response from such detectors are suitably processed and distributed with respect to the signal strength which is proportional to incident energy. This distribution is normally referred as energy spectrum and is recorded in the multichannel analyser. The measurement of energy and intensity of radiation from the spectrum is called radiation spectrometry. Thus the radiation spectrometry allows the identification and quantification of radioactive isotopes in variety of matrices. The radiation spectrometry has now become a popular radioanalytical technique in wide area of nuclear fuel cycle programs. The popular spectrometry techniques commonly used for the radioactivity measurement and analysis are Alpha spectrometry, Gamma ray spectrometry and Beta spectrometry

Imaging mass spectrometry statistical analysis.

Science.gov (United States)

Jones, Emrys A; Deininger, Sören-Oliver; Hogendoorn, Pancras C W; Deelder, André M; McDonnell, Liam A

2012-08-30

Imaging mass spectrometry is increasingly used to identify new candidate biomarkers. This clinical application of imaging mass spectrometry is highly multidisciplinary: expertise in mass spectrometry is necessary to acquire high quality data, histology is required to accurately label the origin of each pixel's mass spectrum, disease biology is necessary to understand the potential meaning of the imaging mass spectrometry results, and statistics to assess the confidence of any findings. Imaging mass spectrometry data analysis is further complicated because of the unique nature of the data (within the mass spectrometry field); several of the assumptions implicit in the analysis of LC-MS/profiling datasets are not applicable to imaging. The very large size of imaging datasets and the reporting of many data analysis routines, combined with inadequate training and accessible reviews, have exacerbated this problem. In this paper we provide an accessible review of the nature of imaging data and the different strategies by which the data may be analyzed. Particular attention is paid to the assumptions of the data analysis routines to ensure that the reader is apprised of their correct usage in imaging mass spectrometry research. Copyright © 2012 Elsevier B.V. All rights reserved.

Espíritos cheios de bichos: A fauna nas viagens de Louis Agassiz e Richard Francis Burton pelo Brasil oitocentista

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Janaina Zito Losada

2015-04-01

Full Text Available O Brasil do século XIX foi alvo de inúmeras viagens realizadas por cientistas estrangeiros. O objetivo deste artigo é analisar as impressões sobre a fauna brasileira presentes nos relatos das viagens realizadas pelo naturalista suíço Louis Agassiz, em 1865, e pelo explorador inglês Richard Francis Burton, em 1868. Destes relatos privilegiam-se as descrições do meio natural de diferentes regiões brasileiras e das particularidades da fauna silvestre por eles encontrada.

Ninth ISMAS workshop on mass spectrometry

International Nuclear Information System (INIS)

Aggarwal, S.K.

2000-12-01

Mass spectrometry has wide-ranging applications in such diverse areas as nuclear industry, agriculture, drugs, environment, petroleum and lentils. There is an urgent need to absorb and assimilate state-of-the-art technological developments in the field. Emerging trends in atomic mass spectrometry, advances in organic mass spectrometry, qualitative and quantitative analyses by mass spectrometry and mass spectrometry in oceanography are some of the areas that need to be expeditiously examined and are covered in this volume. Papers relevant to INIS are indexed separately

Sample Preprocessing For Atomic Spectrometry

International Nuclear Information System (INIS)

Kim, Sun Tae

2004-08-01

This book gives descriptions of atomic spectrometry, which deals with atomic absorption spectrometry such as Maxwell-Boltzmann equation and Beer-Lambert law, atomic absorption spectrometry for solvent extraction, HGAAS, ETASS, and CVAAS and inductively coupled plasma emission spectrometer, such as basic principle, generative principle of plasma and device and equipment, and interferences, and inductively coupled plasma mass spectrometry like device, pros and cons of ICP/MS, sample analysis, reagent, water, acid, flux, materials of experiments, sample and sampling and disassembling of sample and pollution and loss in open system and closed system.

La chiesa di Richard Meier a Tor Tre Teste e il suo contributo al consolidamento identitario dei nuovi quartieri romani oltre il GRA / The church designed by Richard Meier in Tor Tre Teste and the identity consolidation in the new roman neighbourhoods beyond the Great Circular Road

Directory of Open Access Journals (Sweden)

Giuseppe Bonaccorso

2014-06-01

Full Text Available Il contributo proposto ha l’obiettivo di analizzare alcuni significativi brani del tessuto urbano della periferia est di Roma, adottando metodi interpretativi legati alla storia, alla società, alla programmazione urbanistica e alla costruzione. Gli aspetti salienti del quadrante orientale della periferia romana verranno così delineati partendo “dal di dentro”, sottolineandone i percorsi, gli spazi e i nuclei compositivi che sono all’origine della struttura e della forma stessa dei quartieri disposti a cavallo del Grande Raccordo Anulare. In questo ambito, si pone l’attenzione su alcuni episodi chiave che vedono protagoniste le nuove chiese che riescono a creare una centralità all’interno dei quartieri periferici sostituendo le biblioteche, le piazze e i centri commerciali.  Analizzando da vicino questi esempi, si scopre come di recente sono state realizzate chiese firmate da architetti di fama internazionale proprio allo scopo di rafforzare, o meglio di costruire, un fattore identitario per ciascun quartiere ubicato nel settore orientale della città. Partendo quindi dal generale si arriva a indagare una chiesa e un quartiere che possono essere considerati un modello da seguire per tutta la periferia a ridosso del GRA: la chiesa giubilare di Dio Padre Misericordioso progettata da Richard Meier nel quartiere di Tor Tre Teste. La sequenzialità degli eventi che hanno contraddistinto il concorso per la progettazione della chiesa, la scelta della proposta di Richard Meier, la complessità del cantiere, l’analisi tecnica, stilistica e simbolica della realizzazione finale sono quindi analizzate nell’ambito del rapporto con il quartiere e del tentativo di realizzare (attraverso di essa un centro di attrazione per tutta la periferia.   The article analyses some significant parts of the urban tissue at the eastern periphery of Rome, using the interpretative methods inherent to history, society, urban programming and construction

Software for nuclear spectrometry

International Nuclear Information System (INIS)

1998-10-01

The Advisory Group Meeting (AGM) on Software for Nuclear Spectrometry was dedicated to review the present status of software for nuclear spectrometry and to advise on future activities in this field. Because similar AGM and consultant's meetings had been held in the past; together with an attempt to get more streamlined, this AGM was devoted to the specific field of software for gamma ray spectrometry. Nevertheless, many of the issues discussed and the recommendations made are of general concern for any software on nuclear spectrometry. The report is organized by sections. The 'Summary' gives conclusions and recommendations adopted at the AGM. These conclusions and recommendations resulted from the discussions held during and after presentations of the scientific and technical papers. These papers are reported here in their integral form in the following Sections

Poets/Trump/Philosophers: Reflections on Richard Rorty’s Liberalism, Ten Years after His Death

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Giorgio Baruchello

2017-08-01

Full Text Available Starting with a prescient 1998 quote on the impending decline of US liberal democracy into right-wing, strong-man-based demagogy, this paper outlines Richard Rorty’s political philosophy, which I believe can help us understand perplexing political trends in today’s political reality well beyond the US alone. Specifically, I tackle three key-terms encapsulating the thrust of Rorty’s political philosophy, i.e. “liberalism of fear”, “bourgeois” and “postmodernism”. Also, I address a contraposition that explains how Rorty would approach and attempt to defend liberal democracy from contemporary right-wing, strong-man-based degenerations, namely the priority of “poetry” over “philosophy”. Essentially, if one wishes to win in the political arena, she must be armed with the most effective rhetorical weaponry, however good, solid and well-argued her political views may be. Finally, some remarks are offered on the role that “philosophy” can still play within the same arena.

Três décadas de genes egoístas: Discutindo algumas premissas do best seller de Richard Dawkins

OpenAIRE

Vieira, Eduardo Paiva de Pontes; Chaves, Silvia Nogueira

2011-01-01

O presente trabalho resgata algumas idéias do biólogo evolucionista Richard Dawkins, apresentadas pela primeira vez em seu best-seller O Gene Egoísta (The Selfish Gene), de 1976. O caráter polêmico de algumas concepções ultradarwinistas e sociobiológicas da obra é campo fértil para o embate de idéias, revelando um universo rico para discussões em diversas frentes, especialmente aquelas que podem se desenvolver na formação crítica de alguns profissionais vinculados á ciências biológicas, socio...

Flame emission, atomic absorption and fluorescence spectrometry

International Nuclear Information System (INIS)

Horlick, G.

1980-01-01

Six hundred and thirty references are cited in this review. The information in the review is divided into 12 major areas: books, reviews, and bibliographies; fundamental studies in flames; developments in instrumentation; measurement techniques and procedure; flame emission spectrometry; flame atomic absorption spectrometry; flame molecular absorption spectrometry; electrothermal atomization atomic absorption spectroscopy; hydride generation techniques; graphite furnace atomic emission spectrometry; atomic fluorescence spectrometry; and analytical comparisons

Richard Rorty:From Anti-metaphysical Neo-Pragmatism to Rejection of Philosophy

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M. Akrami

2010-01-01

Full Text Available Richard Rorty is a neo-Pragmatist philosopher. For three decades, he has attacked the traditional philosophy (from Plato to Kant as well as any other epistemology searching for truth or claiming to mirror the nature in his philosophical works. Rorty holds that, according to the history of philosophy in his reading, there is no final answer to the traditional questions concerning knowledge, truth, and representation. These questions, therefore, should be dissolved and denied. He maintains that knowledge is justified belief, justification, however, being not the consequence of some correspondence between the theory or the statement, but the consequence of conversation, social practice, group consensus, and social solidarity. Rorty also thinks that democracy has priority on philosophy, disagreeing with the thesis that philosophy is the foundation of the rest of culture.Despite of usefulness of some elements and implications of Rorty’s metaphilosophy (such as his emphasis on freedom, democracy, and pluralism as well as his insisting on philosophical humility and avoiding scientific pride, it is faced with several problems, including 1 ignoring the referential and realist features of language, 2 confusing interpretation and reality, 3 eliminating the border between objectivity and subjectivity, 4 interfering of public and private life, and 5 ignoring the need of science, culture, technology and, in particular, politics, in philosophy. The authors try to show and analyze some elements of these problems.

Mass spectrometry in clinical chemistry

International Nuclear Information System (INIS)

Pettersen, J.E.

1977-01-01

A brief description is given of the functional elements of a mass spectrometer and of some currently employed mass spectrometric techniques, such as combined gas chromatography-mass spectrometry, mass chromatography, and selected ion monitoring. Various areas of application of mass spectrometry in clinical chemistry are discussed, such as inborn errors of metabolism and other metabolic disorders, intoxications, quantitative determinations of drugs, hormones, gases, and trace elements, and the use of isotope dilution mass spectrometry as a definitive method for the establishment of true values for concentrations of various compounds in reference sera. It is concluded that mass spectrometry is of great value in clinical chemistry. (Auth.)

Quantum mechanics in the cold war; Quantenmechanik im Kalten Krieg. David Bohm und Richard Feynman

Energy Technology Data Exchange (ETDEWEB)

Forstner, C.

2007-07-01

In the middle of the 20th century David Bohm and Richard Feynman developed two fundamentally different approaches of modern quantum mechanics: Bohm a realistic interpretation by means of hidden parameters and Feynman the path-integral formalism. This is by this more remarakable, because both physicists started from similar conditions and originated from similar connections. By its comparing approach this study presents more than a contribution to the history of the quantum theory. By the question for the social and cultural conditions of the formation of theories it is furthermore of science-sociological and science-theoretical interest. The in the beginning similar and later different binding of both scientists into the scientific community allows furthermore to study, which adapting pressure each group puts on the individual scientist and the fundamental parts of his research, and which new degrees of freedom in the formation of theories arise, when this constraint is cancelled.

Eleventh ISMAS workshop on mass spectrometry

International Nuclear Information System (INIS)

Aggarwal, S.K.; Jaison, P.G.

2004-10-01

This volume deals with the latest developments in this field, exposing the innumerable applications of mass spectrometry. The topics covered include basic fundamentals of mass spectrometry, qualitative and quantitative aspects and data interpretation, maintenance of mass spectrometers, selection of a mass spectrometer, its applications in various branches of science as well as recent advances in mass spectrometry. Emphasis is also laid on the practical aspects of mass spectrometry. Papers relevant to INIS are indexed separately

Mass spectrometry and tandem mass spectrometry of citrus limonoids.

Science.gov (United States)

Tian, Qingguo; Schwartz, Steven J

2003-10-15

Methods for atmospheric pressure chemical ionization tandem mass spectrometry (APCI-MS/MS) of citrus limonoid aglycones and electrospray ionization tandem mass spectrometry (ESI-MS/MS) of limonoid glucosides are reported. The fragmentation patterns of four citrus limonoid aglycones (limonin, nomilin, obacunone, and deacetylnomilin) and six limonoid glucosides, that is, limonin 17-beta-D-glucopyranoside (LG), nomilin 17-beta-D-glucopyranoside (NG), nomilinic acid 17-beta-D-glucopyranoside (NAG), deacetyl nomilinic acid 17-beta-D-glucopyranoside (DNAG), obacunone 17-beta-D-glucopyranoside (OG), and obacunoic acid 17-beta-D-glucopyranoside (OAG) were investigated using a quadruple mass spectrometer in low-energy collisionally activated dissociation (CAD). The four limonoid aglycones and four limonoid glucosides (LG, OG, NAG, and DNAG) were purified from citrus seeds; the other two limonoid glucosides (NG and OAG) were tentatively identified in the crude extract of grapefruit seeds by ESI mass spectrometry in both positive and negative ion analysis. Ammonium hydroxide or acetic acid was added to the mobile phase to facilitate ionization. During positive ion APCI analysis of limonoid aglycones, protonated molecular ion, [M + H]+, or adduct ion, [M + NH3 + H]-, was formed as base peaks when ammonium hydroxide was added to the mobile phase. Molecular anions or adduct ions with acetic acid ([M + HOAc - H] and [M + HOAc]-) or a deprotonated molecular ion were produced during negative ion APCI analysis of limonoid aglycones, depending on the mobile-phase modifier used. Positive ion ESI-MS of limonoid glucosides produced adduct ions of [M + H + NH3]+, [M + Na]+, and [M + K]+ when ammonium hydroxide was added to the mobile phase. After collisionally activated dissociation (CAD) of the limonoid aglycone molecular ions in negative ion APCI analysis, fragment ions indicated structural information of the precursor ions, showing the presence of methyl, carboxyl, and oxygenated ring

Memoria y Estudios Culturales : un acercamiento al relato sobre la propia historia de vida en Raymond Williams y Richard Hoggart

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Sebastián Matías Stra

2018-01-01

Full Text Available [es] Este trabajo intentará recuperar, de forma parcial y fragmentaria, las maneras en que el testimonio en primera persona articulado en el formato de memorias de la propia historia de vida tiene un posible valor metodológico en algunos textos seminales de la conformación de los estudios culturales ingleses. Hablamos particularmente del libro de 1957, The Uses of Literacy: Aspects of Working-class Life, with Special Reference to Publications and Entertainments, de Richard Hoggart y del tradicional artículo Culture is Ordinary de Raymond Williams, publicado en 1958 y que incluye de forma más rudimentaria algunas definiciones que conformaron la primera parte de la obra del autor galés, constituida por los libros Culture and Society y The Long Revolution. [en] This work will attempt to partially and fragmentarily recover the ways in which the testimony in first person articulated in the format of memories of the own history of life has a possible methodological value in some seminal texts of the conformation of the english cultural studies. We refer in special to the 1957 book, The Uses of Literacy: Aspects of Working-class Life, with Special Reference to Publications and Entertainments, by Richard Hoggart and the Raymond Williams' article Culture is Ordinary, published in 1958, which includes, in an incipient way, some of the definitions that formed the first part of the work of the Welsh author, made up of the books Culture and Society and The Long Revolution.

Mass Spectrometry-Based Biomarker Discovery.

Science.gov (United States)

Zhou, Weidong; Petricoin, Emanuel F; Longo, Caterina

2017-01-01

The discovery of candidate biomarkers within the entire proteome is one of the most important and challenging goals in proteomic research. Mass spectrometry-based proteomics is a modern and promising technology for semiquantitative and qualitative assessment of proteins, enabling protein sequencing and identification with exquisite accuracy and sensitivity. For mass spectrometry analysis, protein extractions from tissues or body fluids and subsequent protein fractionation represent an important and unavoidable step in the workflow for biomarker discovery. Following extraction of proteins, the protein mixture must be digested, reduced, alkylated, and cleaned up prior to mass spectrometry. The aim of our chapter is to provide comprehensible and practical lab procedures for sample digestion, protein fractionation, and subsequent mass spectrometry analysis.

Entre el Dios de Paley y el Dios de Bonnet: El Parco Evolucionismo Teísta de Richard Owen

OpenAIRE

Gustavo Caponi

2013-01-01

http://dx.doi.org/10.5007/1808-1711.2013v17n1p71En primer lugar, en este artículo se examina el carácter de las putativas referencias a la evolución de las especies que encontramos en las obras que Richard Owen publicó antes de 1858; y luego se analizan las escazas y vagas conjeturas evolucionistas que Owen sin duda formuló con posterioridad a la presentación pública de la Teoría de la Selección Natural.  En lo que respecta a lo primero, el objetivo es subrayar la ambigüedad de esas referenci...

Exact solutions to traffic density estimation problems involving the Lighthill-Whitham-Richards traffic flow model using mixed integer programming

KAUST Repository

Canepa, Edward S.; Claudel, Christian G.

2012-01-01

This article presents a new mixed integer programming formulation of the traffic density estimation problem in highways modeled by the Lighthill Whitham Richards equation. We first present an equivalent formulation of the problem using an Hamilton-Jacobi equation. Then, using a semi-analytic formula, we show that the model constraints resulting from the Hamilton-Jacobi equation result in linear constraints, albeit with unknown integers. We then pose the problem of estimating the density at the initial time given incomplete and inaccurate traffic data as a Mixed Integer Program. We then present a numerical implementation of the method using experimental flow and probe data obtained during Mobile Century experiment. © 2012 IEEE.

Exact solutions to traffic density estimation problems involving the Lighthill-Whitham-Richards traffic flow model using mixed integer programming

KAUST Repository

Canepa, Edward S.

2012-09-01

This article presents a new mixed integer programming formulation of the traffic density estimation problem in highways modeled by the Lighthill Whitham Richards equation. We first present an equivalent formulation of the problem using an Hamilton-Jacobi equation. Then, using a semi-analytic formula, we show that the model constraints resulting from the Hamilton-Jacobi equation result in linear constraints, albeit with unknown integers. We then pose the problem of estimating the density at the initial time given incomplete and inaccurate traffic data as a Mixed Integer Program. We then present a numerical implementation of the method using experimental flow and probe data obtained during Mobile Century experiment. © 2012 IEEE.

The combined measurement of uranium by alpha spectrometry and secondary ion mass spectrometry (SIMS)

International Nuclear Information System (INIS)

Harvan, D.

2009-01-01

The aim of thesis was to found the dependence between radiometric method - alpha spectrometry and surface sensitive method - Secondary Ion Mass Spectrometry (SIMS). Uranium or naturally occurring uranium isotopes were studied. Samples (high polished stainless steel discs) with uranium isotopes were prepared by electrodeposition. Samples were measured by alpha spectrometry after electrodeposition and treatment. It gives surface activities. Weights, as well as surface's weights of uranium isotopes were calculated from their activities, After alpha spectrometry samples were analyzed by TOF-SIMS IV instrument in International Laser Centre in Bratislava. By the SIMS analysis intensities of uranium-238 were obtained. The interpretation of SIMS intensities vs. surface activity, or surface's weights of uranium isotopes indicates the possibility to use SIMS in quantitative analysis of surface contamination by uranium isotopes, especially 238 U. (author)

Shakespeare for all Seasons ? Richard II en Avignon : de Jean Vilar (1957 à Ariane Mnouchkine (1982 Shakespeare for All Seasons? Richard II at the Avignon Festival: from Jean Vilar (1957 to Ariane Mnouchkine (1982

Directory of Open Access Journals (Sweden)

Isabelle Schwartz-Gastine

2009-06-01

Full Text Available Richard II has not often been performed on the French stage; however, in the 20th century, within a period of 35 years, two productions premiered at the same venue (the Cour d’Honneur at the open-air Avignon Festival, were so successful that they became emblematic of their times. In 1947 Jean Vilar opened the first Avignon Festival with an ascetic, charismatic eponymous hero who came to an inner knowledge of himself in his bare prison cell; in 1982 Ariane Mnouchkine offered a splendid visual display by transposing the play into the kabuki tradition; this offered the audience breath-taking and dynamic tableaux of elaborate court ceremonies and rebellious lords.At such a distance in time, the English medieval code of honour was dealt with according to completely different theatrical principles of ethics and aesthetics, mirroring the changes in perspective within French society.

Ion mobility spectrometry

CERN Document Server

Eiceman, GA

2005-01-01

Key Developments for Faster, More Precise Detection Capabilities Driven by the demand for the rapid and advanced detection of explosives, chemical and biological warfare agents, and narcotics, ion mobility spectrometry (IMS) undergone significant refinements in technology, computational capabilities, and understanding of the principles of gas phase ion chemistry and mobility. Beginning with a thorough discussion of the fundamental theories and physics of ion mobility, Ion Mobility Spectrometry, Second Edition describes the recent advances in instrumentation and newly

Has David Howden Vindicated Richard von Mises’s Definition of Probability?

Directory of Open Access Journals (Sweden)

Mark R. Crovelli

2009-11-01

Full Text Available In my recent article on these pages (Crovelli 2009 I argued that members of the Austrian School of economics have adopted and defended a faulty definition of probability. I argued that the definition of probability necessarily depends upon the nature of the world in which we live. I claimed that if the nature of the world is such that every event and phenomenon which occurs has a cause of some sort, then probability must be defined subjectively; that is, “as a measure of our uncertainty about the likelihood of occurrence of some event or phenomenon, based upon evidence that need not derive solely from past frequencies of ‘collectives’ or ‘classes.’” I further claimed that the nature of the world is indeed such that all events and phenomena have prior causes, and that this fact compels us to adopt a subjective definition of probability.David Howden has recently published what he claims is a refutation of my argument in his article “Single Trial Probability Applications: Can Subjectivity Evade Frequency Limitations” (Howden 2009. Unfortunately, Mr. Howden appears to not have understood my argument, and his purported refutation of my subjective definition consequently amounts to nothing more than a concatenation of confused and fallacious ideas that are completely irrelevant to my argument. David Howden has thus failed in his attempt to vindicate Richard von Mises’s definition of probability.

Stand diameter distribution modelling and prediction based on Richards function.

Directory of Open Access Journals (Sweden)

Ai-guo Duan

Full Text Available The objective of this study was to introduce application of the Richards equation on modelling and prediction of stand diameter distribution. The long-term repeated measurement data sets, consisted of 309 diameter frequency distributions from Chinese fir (Cunninghamia lanceolata plantations in the southern China, were used. Also, 150 stands were used as fitting data, the other 159 stands were used for testing. Nonlinear regression method (NRM or maximum likelihood estimates method (MLEM were applied to estimate the parameters of models, and the parameter prediction method (PPM and parameter recovery method (PRM were used to predict the diameter distributions of unknown stands. Four main conclusions were obtained: (1 R distribution presented a more accurate simulation than three-parametric Weibull function; (2 the parameters p, q and r of R distribution proved to be its scale, location and shape parameters, and have a deep relationship with stand characteristics, which means the parameters of R distribution have good theoretical interpretation; (3 the ordinate of inflection point of R distribution has significant relativity with its skewness and kurtosis, and the fitted main distribution range for the cumulative diameter distribution of Chinese fir plantations was 0.4∼0.6; (4 the goodness-of-fit test showed diameter distributions of unknown stands can be well estimated by applying R distribution based on PRM or the combination of PPM and PRM under the condition that only quadratic mean DBH or plus stand age are known, and the non-rejection rates were near 80%, which are higher than the 72.33% non-rejection rate of three-parametric Weibull function based on the combination of PPM and PRM.

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

Energy Technology Data Exchange (ETDEWEB)

Burnum-Johnson, Kristin E.; Baker, Erin S.; Metz, Thomas O.

2017-12-01

Successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development of pregnancy related problems at the molecular level. In this perspective, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes.

Kalman filters for assimilating near-surface observations into the Richards equation - Part 2: A dual filter approach for simultaneous retrieval of states and parameters

Science.gov (United States)

Medina, H.; Romano, N.; Chirico, G. B.

2014-07-01

This study presents a dual Kalman filter (DSUKF - dual standard-unscented Kalman filter) for retrieving states and parameters controlling the soil water dynamics in a homogeneous soil column, by assimilating near-surface state observations. The DSUKF couples a standard Kalman filter for retrieving the states of a linear solver of the Richards equation, and an unscented Kalman filter for retrieving the parameters of the soil hydraulic functions, which are defined according to the van Genuchten-Mualem closed-form model. The accuracy and the computational expense of the DSUKF are compared with those of the dual ensemble Kalman filter (DEnKF) implemented with a nonlinear solver of the Richards equation. Both the DSUKF and the DEnKF are applied with two alternative state-space formulations of the Richards equation, respectively differentiated by the type of variable employed for representing the states: either the soil water content (θ) or the soil water matric pressure head (h). The comparison analyses are conducted with reference to synthetic time series of the true states, noise corrupted observations, and synthetic time series of the meteorological forcing. The performance of the retrieval algorithms are examined accounting for the effects exerted on the output by the input parameters, the observation depth and assimilation frequency, as well as by the relationship between retrieved states and assimilated variables. The uncertainty of the states retrieved with DSUKF is considerably reduced, for any initial wrong parameterization, with similar accuracy but less computational effort than the DEnKF, when this is implemented with ensembles of 25 members. For ensemble sizes of the same order of those involved in the DSUKF, the DEnKF fails to provide reliable posterior estimates of states and parameters. The retrieval performance of the soil hydraulic parameters is strongly affected by several factors, such as the initial guess of the unknown parameters, the wet or dry

[Richard C. M. Mole: The Baltic states from the Soviet Union to the European Union. Identity, discourse and power in the post-communist transition of Estonia, Latvia and Lithuania] / Karsten Brüggemann

Index Scriptorium Estoniae

Brüggemann, Karsten, 1965-

2014-01-01

Arvustus: Mole, Richard C. M. The Baltic States from the Soviet Union to the European Union : identity, discourse and power in the post-communist transition of Estonia, Latvia and Lithuania. London ; New York : Routledge, 2012, 2013

Unreliability and the Animal Narrator in Richard Adams’s The Plague Dogs

Directory of Open Access Journals (Sweden)

Anja Höing

2017-03-01

Full Text Available Richard Adams’s talking animal story The Plague Dogs (1978, with its deeply genre-atypical mode of narration, offers a multiplicity of avenues to explore the literary animal as animal. The story draws much of its power from the psychological complexity and related unreliability of both canine narrators, two research lab escapees gone feral. Both the terrier Snitter and the black mongrel Rowf are mentally ill and experience a highly subjective, part-fantastic world. In episodes of zero focalization, a sarcastic voice comments on the plot from the off, aggressively attacking a thoroughly anthropocentric superstructure the protagonists themselves are oblivious of, and presenting all that is normally constructed as “rational” in the implied reader’s world as a carnivalesque farce. Combining these equally unreliable narratives, The Plague Dogs creates a unique mixture of what Phelan (2007 calls “estranging” and “bonding” unreliability and brings to light the devastating consequences of anthropocentrism. The Plague Dogs not only defamiliarizes a genre usually committed to conventional means of storytelling, but the dominant Western conception of the status of animals in the world, showing that once we start to read the animal as animal, this sets into motion an avalanche of other concepts in need of re-reading, among them the very ones making up the fundamental pillars of Western societies’ anthropocentric self-conception.

Preface Miniaturization and Mass Spectrometry

NARCIS (Netherlands)

Unknown, [Unknown; le Gac, Severine; le Gac, S.; van den Berg, Albert; van den Berg, A.

2009-01-01

Miniaturization and Mass Spectrometry illustrates this trend and focuses on one particular analysis technique, mass spectrometry whose popularity has "dramatically" increased in the last two decades with the explosion of the field of biological analysis and the development of two "soft" ionization

La France au Tsar : chanson patriotique créée par Marius Richard à la Scala, Henri Helme à Ba-ta-clan [illustration couleurs Donjean

OpenAIRE

François Bigot Éditeur , .; Daphy , Éliane

2010-01-01

La France au Tsar : chanson patriotique créée par Marius Richard à la Scala, Henri Helme à Ba-ta-clan ; paroles de Lucien Colonge, Musique de J. Claudel. [Illustration couleurs signée] Donjean. A la chanson populaire, Maison Bigot éditeur (sans cotage, sans ©, datation recherche en cours). Titre inconnu du catalogue BNF. Datation provisoire par année de dépôt médihal (2010)

Glycomics using mass spectrometry

OpenAIRE

Wuhrer, Manfred

2013-01-01

Mass spectrometry plays an increasingly important role in structural glycomics. This review provides an overview on currently used mass spectrometric approaches such as the characterization of glycans, the analysis of glycopeptides obtained by proteolytic cleavage of proteins and the analysis of glycosphingolipids. The given examples are demonstrating the application of mass spectrometry to study glycosylation changes associated with congenital disorders of glycosylation, lysosomal storage di...

Mass spectrometry of long-lived radionuclides

International Nuclear Information System (INIS)

Becker, Johanna Sabine.

2003-01-01

The capability of determining element concentrations at the trace and ultratrace level and isotope ratios is a main feature of inorganic mass spectrometry. The precise and accurate determination of isotope ratios of long-lived natural and artificial radionuclides is required, e.g. for their environmental monitoring and health control, for studying radionuclide migration, for age dating, for determining isotope ratios of radiogenic elements in the nuclear industry, for quality assurance and determination of the burn-up of fuel material in a nuclear power plant, for reprocessing plants, nuclear material accounting and radioactive waste control. Inorganic mass spectrometry, especially inductively coupled plasma mass spectrometry (ICP-MS) as the most important inorganic mass spectrometric technique today, possesses excellent sensitivity, precision and good accuracy for isotope ratio measurements and practically no restriction with respect to the ionization potential of the element investigated--therefore, thermal ionization mass spectrometry (TIMS), which has been used as the dominant analytical technique for precise isotope ratio measurements of long-lived radionuclides for many decades, is being replaced increasingly by ICP-MS. In the last few years instrumental progress in improving figures of merit for the determination of isotope ratio measurements of long-lived radionuclides in ICP-MS has been achieved by the application of a multiple ion collector device (MC-ICP-MS) and the introduction of the collision cell interface in order to dissociate disturbing argon-based molecular ions, to reduce the kinetic energy of ions and neutralize the disturbing noble gas ions (e.g. of 129 Xe + for the determination of 129 I). The review describes the state of the art and the progress of different inorganic mass spectrometric techniques such as ICP-MS, laser ablation ICP-MS vs. TIMS, glow discharge mass spectrometry, secondary ion mass spectrometry, resonance ionization mass

The Effect of Richard Wagner's Music and Beliefs on Hitler's Ideology

Directory of Open Access Journals (Sweden)

Carolyn S. Ticker

2016-09-01

Full Text Available The Holocaust will always be remembered as one of the most horrific and evil events in all of history. One question that has been so pervasive in regards to this historical event is the question of why. Why exactly did Hitler massacre the Jewish people? Why did he come to the conclusion that the Jews were somehow lesser than him, and that it was okay to kill them? What and who were his influences and how did they help form Hitler’s opinions leading up to the Holocaust? Although more than one situation or person influenced Hitler, I believe that one man in particular really helped contribute to Hitler’s ideas, especially about the Jewish people. This man is the famous musician Richard Wagner. While musicologists admit that Wagner was a musical genius, one aspect of his career that is hard to ignore is his strong antisemitism. In addition to speaking about his hatred for the Jews, he also wrote about it in his music, making it hard to glance over. Hitler had been close to the Wagner family, and had an obsessive, cult-like infatuation with Wagner’s music beginning in his childhood. This infatuation with Wagner’s music and his closeness to his later family helped facilitate and solidify his negative views about the Jewish people. In this paper I will explore the antisemitism that is within Wagner’s music and writing, and then I will discuss how Wagner’s antisemitism helped inform, influence, and shape Hitler’s ideas, indirectly assisting in the propagation of the Holocaust.

Reliability of graphite furnace atomic absorption spectrometry as ...

African Journals Online (AJOL)

spectrometry as alternative method for trace analysis of ... Purpose: To evaluate the comparative efficiency of graphite furnace atomic absorption spectrometry .... Methods comparison and validation .... plasma-optical emission spectrometry.

Obituary: Richard B. Dunn, 1927-2005

Science.gov (United States)

Keil, Stephen L.; Dooling, David

2007-12-01

Dr. Richard B. Dunn, astronomer emeritus at the National Solar Observatory, died of a heart attack on September 29, 2005. He was recognized as one of the foremost experimental solar physicists. His innovative designs for telescopes and instruments led to many important discoveries in solar physics. Born in Baltimore, Maryland, in 1927 and raised in Minneapolis, Minnesota, Dick's parents were Dr. Halbert L. Dunn and Katherine Brandner. Halbert (MD, Ph.D., F.A.P.H.A.) was an physician who became Chief of the National Office of Vital Statistics, Public Health Service. He published a paper "High Level Wellness for Man and Society" that became the founding paper of the field of wellness health care. After their divorce in 1942, Katherine moved to New York and became a social worker. Dick had two older brothers who died before him, Halbert (born in 1921, who became a civil engineer) and Robert (born in 1924, who became an architect). Dick earned a BS in mechanical engineering and an MS in astronomy at the University of Minnesota. At the end of World War II he served in the United States Army in Japan. For his master's degree, Dick undertook the design and construction of a Lyot-type birefringent filter for observations of solar prominences. This early work led to his acceptance at Harvard, where Professor Donald Menzel encouraged him to continue his work with the 15-inch Cambridge telescope. In 1951 he conducted part of his doctoral thesis work at the fledgling Sacramento Peak Observatory in southern New Mexico. The observatory director, Dr. John Evans, was impressed with Dick's outstanding instrumental talents and invited him to join as one of the first scientific staff members. During his first few years at Sac Peak, Dick developed two more birefringent filter systems including one with an integrated coronagraph. With this system, he produced the best prominence and spicule observations ever obtained. Dick's career was dedicated to obtaining solar observations of the

Entre el Dios de Paley y el Dios de Bonnet: El Parco Evolucionismo Teísta de Richard Owen

Directory of Open Access Journals (Sweden)

Gustavo Caponi

2013-04-01

Full Text Available Firstly, in this article it is examined the nature of the putative remarks concerning evolution of species that are found in the works that Richard Owen published before 1858; and then it is made the same thing with the few and vague evolutionist conjectures that Owen certainly made after the public presentation of Natural Selection Theory. Regarding the former topic, the goal will be to highlight the ambiguity of those Owen’s remarks, and concerning the latter topic what is looked for is to show that, when he explained his transmutationist thesis, Owen didn’t go beyond a pious theistic evolutionism, without postulating any mechanism of evolutionary change and remaining faithful to Design Theology praised by Paley.

HOW CAN LOVE BE VIOLENT? REFLECTIONS ON RICHARD OF ST.VICTOR’S ON THE FOUR DEGREES OF VIOLENT LOVE

Directory of Open Access Journals (Sweden)

MARIUS TALOŞ

2012-05-01

Full Text Available The following article focuses on Richard of St. Victor´s most original treatise: On the Four Degrees of Violent Love. Although the topic of violence within the Christian view on ethics, politics and theology was not at all new by 1173, the major contribution of this short but dense mystical writing consists in developing systematically the violence as an inherent consequence of the infinite charity. The love is so powerful that it “wounds, binds, languishes and brings on a faint”, but the same force may have different effects: if these four steps appear to be destructive when oriented to satisfy the “profane” desires, their infinite strength show providential effects when turned to the divine source of the charity.

Laboratory of acceleration mass spectrometry

International Nuclear Information System (INIS)

Hybler, P.; Chrapan, J.

2002-01-01

In this paper authors describe the principle of the method of acceleration mass spectrometry and the construction plans of this instrument at the Faculty of ecology and environmental sciences in Banska Stiavnica. Using of this instrument for radiocarbon dating is discussed. A review of laboratories with acceleration mass spectrometry is presented

Richard Francis Burton e a inserÃÃo do kama-sutras como um manual sexual entre os vitorianos (Inglaterra, 1883)

OpenAIRE

Felipe Salvador Weissheimer

2014-01-01

Dentre os vÃrios âKama-sutrasâ difundidos no mercado, a versÃo clÃssica foi escrita por Vatsyayana (sÃculo I-IV, aproximadamente) e publicada na Inglaterra em 1883 pela Sociedade Hindu Kama-Shastra. Richard Francis Burton foi o membro de maior importÃncia na Sociedade Hindu Kama-Shastra, pois, alÃm de fomentar a publicaÃÃo, auxiliou na traduÃÃo, editou e enunciou vÃrios comentÃrios ao longo da obra. Em seus comentÃrios, percebemos que o projeto da traduÃÃo e publicaÃÃo do Kama-sutras visava e...

Thirteenth ISMAS symposium cum workshop on spectrometry

International Nuclear Information System (INIS)

Aggarwal, S.K.; Jaison, P.G.; Alamelu, D.

2008-01-01

Mass spectrometry is an important analytical tool and finds applications in almost all branches of science and technology like Physics, Chemistry, Biology, Material Science, Geology, Nuclear Science, Industry, Oceanography, Environment etc. Innovations in the designs of mass spectrometers coupled with new ionization techniques have further strengthened the capabilities of mass spectrometry for analyzing all types of molecules including thermally labile and non-volatile at concentrations down to femto gram levels. The applications of mass spectrometry to the biomedical sciences have provided a unique, easy and fast approach to genomics, proteomics and metabolomics. The availability of different types of mass spectrometers for inorganic elemental and isotopic composition determination have strengthened the role of mass spectrometry for analyzing all elements starting from hydrogen onwards. It is now possible to carry out speciation analysis using electrospray mass spectrometry. The individual conference papers in the proceedings covers fundamentals of mass spectrometry, qualitative and quantitative aspects and data interpretation, maintenance of mass spectrometers, selection of mass spectrometer, and recent advances in the field. Papers relevant to INIS are indexed separately

Modelos de crescimento resultantes da combinação e variações dos modelos de Chapman-Richards e Silva-Bailey aplicados em Leucaena leucocephala (Lam. de Wit.

Directory of Open Access Journals (Sweden)

Cícero Carlos Ramos de Brito

2010-08-01

Full Text Available O objetivo deste trabalho foi desenvolver novos modelos de crescimento para recursos florestais aplicados à leucena [Leucaena leucocephala (Lam. de Wit], tendo como base as hipóteses biológicas propostas por Chapman-Richards e Silva-Bailey. O experimento de leucena foi conduzido na Estação Experimental da Empresa Pernambucana de Pesquisa Agropecuária - IPA, Caruaru, PE. Foram utilizadas 544 árvores de leucena de um experimento com vinte remedições realizadas ao longo de 12 anos. Compararam-se novos modelos de crescimento resultantes da combinação e variações dos modelos de Chapman-Richards e Silva-Bailey, bem como outros comumente usados em recursos florestais. Para a seleção das equações, utilizaram-se o Índice de Ajuste (IA, o erro-padrão da estimativa e a distribuição gráfica dos resíduos. Os resultados indicaram que todos os modelos testados se ajustaram de maneira satisfatória aos dados, podendo ser utilizados para se estimar o crescimento em altura da leucena.

Role of Mass Spectrometry in Clinical Endocrinology.

Science.gov (United States)

Ketha, Siva S; Singh, Ravinder J; Ketha, Hemamalini

2017-09-01

The advent of mass spectrometry into the clinical laboratory has led to an improvement in clinical management of several endocrine diseases. Liquid chromatography tandem mass spectrometry found some of its first clinical applications in the diagnosis of inborn errors of metabolism, in quantitative steroid analysis, and in drug analysis laboratories. Mass spectrometry assays offer analytical sensitivity and specificity that is superior to immunoassays for many analytes. This article highlights several areas of clinical endocrinology that have witnessed the use of liquid chromatography tandem mass spectrometry to improve clinical outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

Staging Unincorporated Power: Richard Harding Davis and the Critique of Imperial News

Directory of Open Access Journals (Sweden)

Nirmal Trivedi

2011-12-01

Full Text Available This essay contextualizes the work of war correspondent Richard Harding Davis within an evolving “imperial news apparatus” that would culminate in his reporting of the Spanish-American War. Critics have conventionally framed Davis squarely within the imperial cause, associating him with his admirer Roosevelt and naval admiral Alfred T. Mahan. Contrary to readings of Davis as an apologist for US imperialism, Trivedi contends that Davis understood how US imperial power relied on an information apparatus to communicate to an increasingly media-conscious American public through culture, that is, via familiar narratives, symbols, and objects—what Trivedi calls “imperial news.” The essay follows Davis’s development from his fictional representation of the new war correspondent in “The Reporter Who Made Himself King” to his own war correspondence before and after the Spanish-American War as collected in the memoirs A Year from a Reporter’s Notebook (1897, Cuba in War Time (1897, and Notes of a War Correspondent (1912. Davis’s war correspondence and fictional work effectively stage US imperialism as “unincorporated power”: that is, as power reliant on a developing news-making apparatus that deploys particular discursive strategies to validate its political claims. This staging critiques strategies of US imperial sovereignty—specifically its “privatization of knowledge” and its promotion of the war correspondent as nothing more than a spectator and purveyor of massacres.

Staging Unincorporated Power: Richard Harding Davis and the Critique of Imperial News

Directory of Open Access Journals (Sweden)

Nirmal Trivedi

2011-12-01

Full Text Available This essay contextualizes the work of war correspondent Richard Harding Davis within an evolving “imperial news apparatus” that would culminate in his reporting of the Spanish-American War. Critics have conventionally framed Davis squarely within the imperial cause, associating him with his admirer Roosevelt and naval admiral Alfred T. Mahan. Contrary to readings of Davis as an apologist for US imperialism, Trivedi contends that Davis understood how US imperial power relied on an information apparatus to communicate to an increasingly media-conscious American public through culture, that is, via familiar narratives, symbols, and objects—what Trivedi calls “imperial news.” The essay follows Davis’s development from his fictional representation of the new war correspondent in “The Reporter Who Made Himself King” to his own war correspondence before and after the Spanish-American War as collected in the memoirs A Year from a Reporter’s Notebook (1897, Cuba in War Time (1897, and Notes of a War Correspondent (1912. Davis’s war correspondence and fictional work effectively stage US imperialism as “unincorporated power”: that is, as power reliant on a developing news-making apparatus that deploys particular discursive strategies to validate its political claims. This staging critiques strategies of US imperial sovereignty—specifically its “privatization of knowledge” and its promotion of the war correspondent as nothing more than a spectator and purveyor of massacres.

Fourier Transform Mass Spectrometry

Science.gov (United States)

Scigelova, Michaela; Hornshaw, Martin; Giannakopulos, Anastassios; Makarov, Alexander

2011-01-01

This article provides an introduction to Fourier transform-based mass spectrometry. The key performance characteristics of Fourier transform-based mass spectrometry, mass accuracy and resolution, are presented in the view of how they impact the interpretation of measurements in proteomic applications. The theory and principles of operation of two types of mass analyzer, Fourier transform ion cyclotron resonance and Orbitrap, are described. Major benefits as well as limitations of Fourier transform-based mass spectrometry technology are discussed in the context of practical sample analysis, and illustrated with examples included as figures in this text and in the accompanying slide set. Comparisons highlighting the performance differences between the two mass analyzers are made where deemed useful in assisting the user with choosing the most appropriate technology for an application. Recent developments of these high-performing mass spectrometers are mentioned to provide a future outlook. PMID:21742802

Symposium on accelerator mass spectrometry

Energy Technology Data Exchange (ETDEWEB)

None

1981-01-01

The area of accelerator mass spectrometry has expanded considerably over the past few years and established itself as an independent and interdisciplinary research field. Three years have passed since the first meeting was held at Rochester. A Symposium on Accelerator Mass Spectrometry was held at Argonne on May 11-13, 1981. In attendance were 96 scientists of whom 26 were from outside the United States. The present proceedings document the program and excitement of the field. Papers are arranged according to the original program. A few papers not presented at the meeting have been added to complete the information on the status of accelerator mass spectrometry. Individual papers were prepared separately for the data base.

Symposium on accelerator mass spectrometry

International Nuclear Information System (INIS)

1981-01-01

The area of accelerator mass spectrometry has expanded considerably over the past few years and established itself as an independent and interdisciplinary research field. Three years have passed since the first meeting was held at Rochester. A Symposium on Accelerator Mass Spectrometry was held at Argonne on May 11-13, 1981. In attendance were 96 scientists of whom 26 were from outside the United States. The present proceedings document the program and excitement of the field. Papers are arranged according to the original program. A few papers not presented at the meeting have been added to complete the information on the status of accelerator mass spectrometry. Individual papers were prepared separately for the data base

Mass spectrometry. [in organic chemistry

Science.gov (United States)

Burlingame, A. L.; Shackleton, C. H. L.; Howe, I.; Chizhov, O. S.

1978-01-01

A review of mass spectrometry in organic chemistry is given, dealing with advances in instrumentation and computer techniques, selected topics in gas-phase ion chemistry, and applications in such fields as biomedicine, natural-product studies, and environmental pollution analysis. Innovative techniques and instrumentation are discussed, along with chromatographic-mass spectrometric on-line computer techniques, mass spectral interpretation and management techniques, and such topics in gas-phase ion chemistry as electron-impact ionization and decomposition, photoionization, field ionization and desorption, high-pressure mass spectrometry, ion cyclotron resonance, and isomerization reactions of organic ions. Applications of mass spectrometry are examined with respect to bio-oligomers and their constituents, biomedically important substances, microbiology, environmental organic analysis, and organic geochemistry.

A REVIEW ON MASS SPECTROMETRY DETECTORS

OpenAIRE

Khatri Neetu; Gupta Ankit; Taneja Ruchi; Bilandi Ajay; Beniwal Prashant

2012-01-01

Mass spectrometry is an analytical technique for "weighing" molecules. Obviously, this is not done with a conventional scale or balance. Instead, mass spectrometry is based upon the principle of the motion of a charged particle that is called an ion, in an electric or magnetic field. The mass to charge ratio (m/z) of the ion affects particles motion. Since the charge of an electron is known, the mass to charge ratio (m/z) is a measurement of mass of an ion. Mass spectrometry research focuses ...

Charles Darwin, Richard Owen, and Natural Selection: A Question of Priority.

Science.gov (United States)

Johnson, Curtis N

2018-05-03

No single author presented Darwin with a more difficult question about his priority in discovering natural selection than the British comparative anatomist and paleontologist Richard Owen. Owen was arguably the most influential biologist in Great Britain in Darwin's time. Darwin wanted his approbation for what he believed to be his own theory of natural selection. Unfortunately for Darwin, when Owen first commented in publication about Darwin's theory of descent he was openly hostile (Edinb. Rev. vol. 111, Article VIII, 1860, pp. 487-533, anonymous). Darwin was taken off-guard. In private meetings and correspondence prior to 1860 Owen had been nothing but polite and friendly, even helping Darwin in cataloguing and analyzing Darwin's zoological specimens from the Beagle voyage. Every early indication predicted a life-long friendship and collaboration. But that was not to be. Owen followed his slashing review with a mounting campaign in the 1860s to denounce and discredit both Darwin and his small but ascendant circle of friends and supporters. But that was not enough for Owen. Starting in 1866, perhaps by now realizing Darwin had landed the big fish, Owen launched a new campaign, to claim the discovery of "Darwin's theory" for himself. Darwin naturally fought back, mainly in the "Historical Sketch" that he prefaced to Origin starting in 1861. But when we peel back the layers of personal animus and escalating vituperation we discover in fact their quarrel was generated more by mutual misunderstanding than scientific disagreement. The battle ended only when Darwin finally penetrated to the crux of the matter and put an end to the rivalry in 1872, in the final version of the Sketch.

Radionuclide content of simulated and fully radioactive SRLLL waste glasses: comparison of results from ICP-MS, gamma spectrometry and alpha spectrometry

International Nuclear Information System (INIS)

Wolf, S.F.; Bates, J.K.

1995-01-01

We have measured the transuranic content of two transuranic=doped, simulated waste glasses, using inductively coupled plasma-mass spectrometry (ICP-MS), γ-spectrometry, and α-spectrometry. Average concentrations measured by each technique were within ± 10% of the as-doped concentrations. We also report the transuranic content of three fully radioactive SRL waste glasses that were determined using γ- and α-spectrometry measurements to deconvolute isobaric interferences present in the ICP-MS analyses

Mass spectrometry at the Pittsburgh conference

International Nuclear Information System (INIS)

Borman, S.

1987-01-01

Each year analytical chemists flock to the Pittsburgh Conference to learn about the latest trends in analytical instrumentation. In this Focus, a number of prominent mass spectroscopists who attended this year's meeting in Atlantic City, NJ, discuss their perceptions of current developments in the field of mass spectrometry (MS). In the June 1 issue of Analytical Chemistry, the authors coverage of the Pittsburgh Conferences continues with a follow-up article on specific developments in hyphenated mass spectrometry - primarily liquid chromatography - MS (LC/MS) and gas chromatography - infrared spectrometry MS (GC/IR/MS)

Chromatography–mass spectrometry in aerospace industry

International Nuclear Information System (INIS)

Buryak, Alexey K; Serduk, T M

2013-01-01

The applications of chromatography–mass spectrometry in aerospace industry are considered. The primary attention is devoted to the development of physicochemical grounds of the use of various chromatography–mass spectrometry procedures to solve topical problems of this industry. Various methods for investigation of the composition of rocket fuels, surfaces of structural materials and environmental media affected by aerospace activities are compared. The application of chromatography–mass spectrometry for the development and evaluation of processes for decontaminations of equipment, industrial wastes and soils from rocket fuel components is substantiated. The bibliography includes 135 references.

Arctic observers: Richard King, monogenism and the historicisation of Inuit through travel narratives.

Science.gov (United States)

Sera-Shriar, Efram

2015-06-01

In 1848 the ethnologist, surgeon and Arctic explorer Richard King (1810-1876) published a three-part series on Inuit in the Journal of the Ethnological Society of London. This series provided a detailed history of Inuit from the eleventh century to the early nineteenth century. It incorporated a mixture of King's personal observations from his experience travelling to the Arctic as a member of George Back's expedition (1833-1835), and the testimonies of other contemporary and historical actors who had written on the subject. The aim was to historicise Inuit through the use of travel reports and show persistent features among the race. King was a monogenist and his sensitive recasting of Inuit was influenced by his participation in a research community actively engaged in humanitarian and abolitionist causes. The physician and ethnologist Thomas Hodgkin (1798-1866) argued that King's research on Inuit was one of the best ethnological approaches to emulate and that it set the standard for the nascent discipline. If we are to take seriously Hodgkin's claim, we should look at how King constructed his depiction of Inuit. There is much to be gained by investigating the practices of nineteenth-century ethnologists because it strengthens our knowledge of the discipline's past and shows how modern understandings of races were formed. Copyright © 2015 Elsevier Ltd. All rights reserved.

Clinical Mass Spectrometry: Achieving Prominence in Laboratory Medicine

Energy Technology Data Exchange (ETDEWEB)

Annesley, Thomas M.; Cooks, Robert G.; Herold, David A.; Hoofnagle, Andrew N.

2016-01-04

Each year the journal Clinical Chemistry publishes a January special issue on a topic that is relevant to the laboratory medicine community. In January 2016 the topic is mass spectrometry, and the issue is entitled “Clinical Mass Spectrometry: Achieving Prominence in Laboratory Medicine”. One popular feature in our issues is a Q&A on a topic, clearly in this case mass spectrometry. The journal is assembling a panel of 5-6 experts from various areas of mass spectrometry ranging from instrument manufacturing to practicing clinical chemists. Dick Smith is one of the scientist requested to participate in this special issue Q&A on Mass Spectrometry. The Q&A Transcript is attached

J.M. Gratale on Tore T. Petersen’s Richard Nixon, Great Britain and the Anglo-American Alignment in the Persian Gulf and Arabian Peninsula

Directory of Open Access Journals (Sweden)

2009-09-01

Full Text Available Tore T. Petersen. Richard Nixon, Great Britain and the Anglo-American Alignment in the Persian Gulf and Arabian Peninsula: Making Allies out of Clients. Sussex Academic Press, 2009.  172pp.  978-1-84519-277-8.Since the events of 9-11 there has been a sizeable quantity of books published on American foreign policy in broad terms, as well as more focused studies on contemporary developments in southwest Asia, more commonly referred to as the Middle East. Many of these volumes are highly politic...

Negative chemical ionization mass spectrometry

International Nuclear Information System (INIS)

Smit, A.L.C.

1979-01-01

This thesis describes some aspects of Negative Chemical Ionization (NCI) mass spectrometry. The reasons for the growing interest in NCI are: (i) to extend the basic knowledge of negative ions and their reactions in the gas phase; (ii) to investigate whether or not this knowledge of negative ions can be used successfully to elucidate the structure of molecules by mass spectrometry. (Auth.)

Burnup determination of mass spectrometry for nuclear fuels

International Nuclear Information System (INIS)

Zhang Chunhua.

1987-01-01

The various methods currently being used in burnup determination of nuclear fuels are studied and reviewed. The mass spectrometry method of destructive testing is discussed emphatically. The burnup determination of mass spectrometry includes heavy isotopic abundance ratio method and isotope dilution mass spectrometry used as burnup indicator for the fission products. The former is applied to high burnup level, but the later to various burnup level. According to experiences, some problems which should be noticed in burnup determination of mass spectrometry are presented

Mass spectrometry-assisted protease substrate screening

DEFF Research Database (Denmark)

Schlüter, Hartmut; Rykl, Jana; Thiemann, Joachim

2007-01-01

-phase chromatography they are analyzed by tandem mass spectrometry and the substrates identified by database searching. The proof of principle in this study is demonstrated by incubating immobilized human plasma proteins with thrombin and by identifying by tandem mass spectrometry the fibrinopeptides, released...

Coincidence gamma-ray spectrometry

DEFF Research Database (Denmark)

Markovic, Nikola; Roos, Per; Nielsen, Sven Poul

2017-01-01

Gamma-ray spectrometry with high-purity germanium (HPGe) detectors is often the technique of choice in an environmental radioactivity laboratory. When measuring environmental samples associated activities are usually low so an important parameter that describes the performance of the spectrometer...... for a nuclide of interest is the minimum detectable activity (MDA). There are many ways for lowering the MDAs in gamma spectrometry. Recently, developments of fast and compact digital acquisition systems have led to growing number of multiple HPGe detector spectrometers. In these applications all detected...

Thinking through war: the social thought of Richard T. Ely, John R. Commons, and Edward A. Ross during the First World War.

Science.gov (United States)

Herzberg, D L

2001-01-01

This paper examines the social thought of University of Wisconsin professors Richard T. Ely, John R. Commons, and Edward A. Ross during World War I. Like many of their fellow scholars, these three were actively involved in the pro-war effort. Although their support for the war was strongly conditioned by personal and occupational considerations, the impact of their wartime service was not restricted to those realms. Their social thought, which they impressed into service explaining and justifying the war, was itself altered in subtle and sometimes surprising ways by the forceful positions they took on the political, economic, and racial significance of the conflict. Copyright 2001 John Wiley & Sons, Inc.

Alpha spectrometry and the secondary ion mass spectrometry of thorium

International Nuclear Information System (INIS)

Strisovska, J.; Kuruc, J.; Galanda, D.; Matel, L.; Aranyosiova, M.; Velic, D.

2009-01-01

The main objective of this master thesis was preparation of samples with thorium content on the steel discs by electrodeposition for determination of natural thorium isotope by alpha spectrometry and the secondary ion mass spectrometry and finding out their possible linear correlation between these methods. The samples with electrolytically excluded isotope of 232 Th were prepared by electrodeposition from solution Th(NO 3 ) 4 ·12 H2 O on steel discs in electrodeposition cell with use of solutions Na 2 SO 4 , NaHSO 4 , KOH and (NH 4 ) 2 (C 2 O 4 ) by electric current 0.75 A. Discs were measured by alpha spectrometer. Activity was calculated from the registered impulses for 232 Th and surface's weight. After alpha spectrometry measurements discs were analyzed by TOF-SIMS IV which is installed in the International Laser Centre in Bratislava. Intensities of isotope of 232 Th and ions of ThO + , ThOH + , ThO 2 H + , Th 2 O 4 H + , ThO 2 - , ThO 3 H - , ThH 3 O 3 - and ThN 2 O 5 H - were identified. The linear correlation is between surface's weights of Th and intensities of ions of Th + from SIMS, however the correlation coefficient has relatively low value. We found out with SIMS method that oxidized and hydride forms of thorium are significantly represented in samples with electroplated thorium. (authors)

Handbook on Mobile Gamma-ray Spectrometry

DEFF Research Database (Denmark)

Aage, Helle Karina; Korsbech, Uffe C C

2003-01-01

Basic physics and mathematics for Airborne and Car-borne Gamma-ray Spectrometry supplemented with practical examples and methods for advanced data processing......Basic physics and mathematics for Airborne and Car-borne Gamma-ray Spectrometry supplemented with practical examples and methods for advanced data processing...

Surface analysis by imaging mass spectrometry

Czech Academy of Sciences Publication Activity Database

Vidová, Veronika; Volný, Michael; Lemr, Karel; Havlíček, Vladimír

2009-01-01

Roč. 74, 7-8 (2009), s. 1101-1116 ISSN 0010-0765 Institutional research plan: CEZ:AV0Z50200510 Keywords : secondary ion mass spectrometry * matrix assisted laser desorption ionization * mass spectrometry Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 0.856, year: 2009

Introduction to mass spectrometry-based proteomics

DEFF Research Database (Denmark)

Matthiesen, R.; Bunkenborg, J.

2013-01-01

Mass spectrometry has been widely applied to study biomolecules and one rapidly developing field is the global analysis of proteins, proteomics. Understanding and handling mass spectrometry data is a multifaceted task that requires many decisions to be made to get the most comprehensive informati...

Providing the physical basis of SCS curve number method and its proportionality relationship from Richards' equation

Science.gov (United States)

Hooshyar, M.; Wang, D.

2016-12-01

The empirical proportionality relationship, which indicates that the ratio of cumulative surface runoff and infiltration to their corresponding potentials are equal, is the basis of the extensively used Soil Conservation Service Curve Number (SCS-CN) method. The objective of this paper is to provide the physical basis of the SCS-CN method and its proportionality hypothesis from the infiltration excess runoff generation perspective. To achieve this purpose, an analytical solution of Richards' equation is derived for ponded infiltration in shallow water table environment under the following boundary conditions: 1) the soil is saturated at the land surface; and 2) there is a no-flux boundary which moves downward. The solution is established based on the assumptions of negligible gravitational effect, constant soil water diffusivity, and hydrostatic soil moisture profile between the no-flux boundary and water table. Based on the derived analytical solution, the proportionality hypothesis is a reasonable approximation for rainfall partitioning at the early stage of ponded infiltration in areas with a shallow water table for coarse textured soils.

Determination of 239Pu and 240Pu isotope ratio for a nuclear bomb particle using X-ray spectrometry in conjunction with γ-ray spectrometry and non-destructive α-particle spectrometry

International Nuclear Information System (INIS)

Poellaenen, R.; Ruotsalainen, K.; Toivonen, H.

2009-01-01

A nuclear bomb particle from Thule containing Pu and U was analyzed using X-ray spectrometry in combination with γ-ray spectrometry and non-destructive α-spectrometry. The main objective was to investigate the possibility to determine the 239 Pu and 240 Pu isotope ratios. Previously, X-ray spectrometry together with the above-mentioned methods has been successfully applied for radiochemically processed samples, but not for individual particles. In the present paper we demonstrate the power of non-destructive analysis. The 239 Pu/( 239 Pu+ 240 Pu) atom ratio for the Thule particle was determined, using two different approaches, to be 0.93±0.07 and 0.91±0.05. These results are consistent with weapons-grade material and the results obtained by other investigators.

Mass spectrometry

DEFF Research Database (Denmark)

Nyvang Hartmeyer, Gitte; Jensen, Anne Kvistholm; Böcher, Sidsel

2010-01-01

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) is currently being introduced for the rapid and accurate identification of bacteria. We describe 2 MALDI-TOF MS identification cases - 1 directly on spinal fluid and 1 on grown bacteria. Rapidly obtained...

Obituary: Richard L. (Dick) Walker, Jr., 1938-2005

Science.gov (United States)

Pier, Jeffrey R.; Mason, Brian

2005-12-01

Koch Center for Science, Math, and Technology at Deerfield Academy in Massachusetts. He also consulted with James Turrell, providing astronomical position information for the design of the Roden Crater Project outside of Flagstaff. While he will be remembered for his significant scientific contributions to the field of astronomy, those who knew Dick, both scientists and non-scientists alike, will probably remember him best for his humility, his humanity, and his loyal and abiding friendship. He was a man with a terrific sense of humor and an infectious laugh. It was always an honor and pleasure to be in his company. Richard L. Walker, Jr. is survived by his wife, Patricia, two daughters from his first marriage: Brenda Walker of Las Vegas, NV, and Pamela Hepburn of Holland, OH, as well as four children from Patricia's first marriage: Doug Browning of Lake Havasu City, AZ, Michael Browning of Kingman, AZ, Kim Bructo of Orient, OH, and Jennifer Brown of Lake Havasu City, AZ. He is also survived by ten grandchildren and three great-grandchildren. He was preceded in death by his father Richard, mother Mary, and daughter, Paula Jean Elizabeth Stone.

Sufi, Christian or Buddhist? Richard Francis Burton’s “Parameters of Belief”

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John Wallen

2013-09-01

Full Text Available Richard Burton has been interpreted and misinterpreted by literary critics as eminent as Edward Said and Louisa Pratt as well as by others such as Rana Kabbani and Reina Lewis. Biographers like Fawn Brody, Edward Rice, Mary Lovell and Jon Godsall have also had their say. Burton has been variously described as imperialist, sexist, gay, obssessed with pornography, racist, plagiarist, sexual libertine, scatologist, expert sociologist, profoundly deceitful and impotent. In spite of this negative press, interest in Burton is always high as his life and times are relevant to many scholars interested in the 19th century origins of modern thought and postcolonial ideas. In this paper presentation I will attempt to get beyond the confused and contradictory portrayals of Burton over the last 50 or so years by looking in some detail at Burton’s two long poems: Stone Talk and The Kasidah. In these works, published 15 years apart, Burton writes under pseudonyms and, as I will argue, is able to express many of his deepest beliefs, especially in The Kasidah where he is playing the part of Hadji Abu Al Yezid, a Sufi like-wise man who possesses some startling similarities to Burton himself. What emerges from this close examination of the texts is a sensitive relativist who, while adhering to the scientific method in all his practical dealings, is yet able to consider the possibility that everything we see around us and all our experience of the world might be, finally, nothing more than Maya and illusion.

Thermal ionisation mass spectrometry (TIMS): what, how and why?

International Nuclear Information System (INIS)

Aggarwal, S.K.

2002-01-01

Thermal ionisation mass spectrometry (TIMS) is one of the oldest mass spectrometric techniques, which has been used for determining the isotopic composition and concentration of different elements using isotope dilution. In spite of the introduction of many other inorganic mass spectrometric techniques like spark source mass spectrometry (SSMS), glow discharge mass spectrometry (GDMS), inductively coupled plasma-mass spectrometry (ICP-MS), secondary ion mass spectrometry (SIMS), the TIMS technique plays the role of a definitive analytical methodology and still occupies a unique position in terms of its capabilities with respect to precision and accuracy as well as sensitivity

Study by Auger spectrometry and mass spectrometry of the chemisorption of carbon monoxide on polycrystalline molybdenum

International Nuclear Information System (INIS)

Gillet, E.; Chiarena, J.C.; Gillet, M.

1976-01-01

A combination of Auger spectrometry and mass spectrometry was employed to study CO chemisorption on polycrystalline Mo surfaces at room temperature. Five adsorption states were observed and the binding parameters (E,n 0 ,tau 0 ) were calculated for the three important states. The results obtained by the two methods are in accord but the occurence of electronic desorption in Auger experiments was pointed out. Contamination effects by C atoms in such studies were investigated by repeated cycles of adsorption-desorption and a characteristic evolution of flash desorption was observed. The results are discussed in this point of view enhancing the importance of a control of the adsorption surface cleanness by a method of great sensibility like Auger spectrometry. (Auth.)

High-sensitivity mass spectrometry with a tandem accelerator

International Nuclear Information System (INIS)

Henning, W.

1984-01-01

The characteristic features of accelerator mass spectrometry are discussed. A short overview is given of the current status of mass spectrometry with high-energy (MeV/nucleon) heavy-ion accelerators. Emphasis is placed on studies with tandem accelerators and on future mass spectrometry of heavier isotopes with the new generation of higher-voltage tandems

Determination of plutonium isotopes in bilberry using liquid scintillation spectrometry and alpha-particle spectrometry

International Nuclear Information System (INIS)

Seferinoğlu, Meryem; Aslan, Nazife; Kurt, Aylin; Erden, Pınar Esra; Mert, Hülya

2014-01-01

This paper presents α-particle spectrometry and liquid scintillation spectrometry methods to determine plutonium isotopes in bilberry. The analytical procedure involves sample preparation steps for ashing, digestion of bilberry samples, radiochemical separation of plutonium radioisotopes and their measurement. The validity of the method was checked for coherence using the ζ test, z-test, relative bias and relative uncertainty outlier tests. The results indicated that the recommended procedures for both measurement systems could be successfully applied for the accurate determination of plutonium activities in bilberry samples. - Highlights: • Sample preparation methods for Pu using LSS and alpha spectrometry developed. • Complete separation of plutonium from interfering radionuclides. • Commercial bilberry was spiked with NPL 2011 (AH-B11144) proficiency test sample. • Results were checked using ζ test, z-test, rel. bias and rel. uncert. outlier tests. • Recommended procedures successfully applied to bilberry samples

You Don't Need Richards'... A New General 1-D Vadose Zone Solution Method that is Reliable

Science.gov (United States)

Ogden, F. L.; Lai, W.; Zhu, J.; Steinke, R. C.; Talbot, C. A.

2015-12-01

Hydrologic modelers and mathematicians have strived to improve 1-D Richards' equation (RE) solution reliability for predicting vadose zone fluxes. Despite advances in computing power and the numerical solution of partial differential equations since Richards first published the RE in 1931, the solution remains unreliable. That is to say that there is no guarantee that for a particular set of soil constitutive relations, moisture profile conditions, or forcing input that a numerical RE solver will converge to an answer. This risk of non-convergence renders prohibitive the use of RE solvers in hydrological models that need perhaps millions of infiltration solutions. In lieu of using unreliable numerical RE solutions, researchers have developed a wide array of approximate solutions that more-or-less mimic the behavior of the RE, with some notable deficiencies such as parameter insensitivity or divergence over time. The improved Talbot-Ogden (T-O) finite water-content scheme was shown by Ogden et al. (2015) to be an extremely good approximation of the 1-D RE solution, with a difference in cumulative infiltration of only 0.2 percent over an 8 month simulation comparing the improved T-O scheme with a RE numerical solver. The reason is that the newly-derived fundamental flow equation that underpins the improved T-O method is equivalent to the RE minus a term that is equal to the diffusive flux divided by the slope of the wetting front. Because the diffusive flux has zero mean, this term is not important in calculating the mean flux. The wetting front slope is near infinite (sharp) in coarser soils that produce more significant hydrological interactions between surface and ground waters, which also makes this missing term 1) disappear in the limit, and, 2) create stability challenges for the numerical solution of RE. The improved T-O method is a replacement for the 1-D RE in soils that can be simulated as homogeneous layers, where the user is willing to neglect the effects

The use of lasers as sources for Raman spectrometry, resonance Raman spectrometry, and light scattering

International Nuclear Information System (INIS)

Capitini, R.; Ceccaldi, M.; Leicknam, J.P.; Plus, R.

1975-01-01

The activity of the laboratory is principally centred on the determination of molecular structures and the study of molecular interactions in solution by infrared and Raman spectrometry. With the development of work on relatively large molecules, particularly biological molecules, it became necessary to complete information on the molecular weight and on the intra and intermolecular geometry and interactions of these bodies. In order to obtain these informations Rayleigh scattering and resonance Raman spectrometry were used. The advantages of using vibrational spectrometry, particularly Raman, in conjunction with the diffusion of light for these structural and molecular interaction studies is emphasized. It is shown that these two techniques could not have developed as they have done in the last few years without the use of lasers as light source [fr

Mass spectrometry a versatile aid to inorganic analysis

International Nuclear Information System (INIS)

Stefani, Rene

1976-01-01

Several hundred publications have appeared in the last three years that deal with applications of Mass Spectrometry to inorganic analysis. Bulk and localized trace analysis, surface and thin film characterization and microstructure examination are currently performed by Secondary Ion Mass Spectrometry, Spark Source Mass Spectrometry and the newly developed Laser Probe Mass Spectrometry. Suitable experimental procedures allow insulators, biologic materials and microsamples to be analysed. In spite of the classification by techniques this review is essentially devoted to the most significant papers in analytical applications but instrumental and basic features are sometimes introduced to support the discussions

Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging.

Science.gov (United States)

Sekuła, Justyna; Nizioł, Joanna; Rode, Wojciech; Ruman, Tomasz

2015-09-21

Silver nanoparticles have been successfully applied as a matrix replacement for the laser desorption/ionization time-of-flight mass spectrometry (LDI-ToF-MS). Nanoparticles, producing spectra with highly reduced chemical background in the low m/z region, are perfectly suited for low-molecular weight compound analysis and imaging. Silver nanoparticles (AgNPs) can efficiently absorb ultraviolet laser radiation, transfer energy to the analyte and promote analyte desorption, but also constitute a source of silver ions suitable for analyte cationisation. This review provides an overview of the literature on silver nanomaterials as non-conventional desorption and ionization promoters in LDI-MS and mass spectrometry imaging.

Performance Test of Alpha Spectrometry for Environmental Radioactivity Analysis

International Nuclear Information System (INIS)

Choi, Jung Youn; Yoon, Jong-Ho; Han, Ki-Tek; Ahn, Gil Hoon

2015-01-01

Environmental samples are analyzed by various methods such as, ICP-MS (inductively coupled plasma mass spectrometry), AMS (accelerator mass spectrometry) TIMS (thermal ionization mass spectrometry), HRGS (high resolution gamma spectrometry) and alpha /beta particle analysis. In this study, we will described the result of performance test using alpha spectrometry for analyzing environmental samples. Measurement data of the U activity using SRM based on extraction chromatography with UTEVA resin. It should be effective way to separate of uranium isotope for the measurement of alpha spectrometry. But, the result of this measurement data is higher than another recovery data. Also concentration of U data is lack of consistency. We leave out of consideration many effect of factors about influence in the experiment process. In the future work, we will try to reduce the step of experiment process and reflect the uncertainty factors

Imaging mass spectrometry in drug development and toxicology.

Science.gov (United States)

Karlsson, Oskar; Hanrieder, Jörg

2017-06-01

During the last decades, imaging mass spectrometry has gained significant relevance in biomedical research. Recent advances in imaging mass spectrometry have paved the way for in situ studies on drug development, metabolism and toxicology. In contrast to whole-body autoradiography that images the localization of radiolabeled compounds, imaging mass spectrometry provides the possibility to simultaneously determine the discrete tissue distribution of the parent compound and its metabolites. In addition, imaging mass spectrometry features high molecular specificity and allows comprehensive, multiplexed detection and localization of hundreds of proteins, peptides and lipids directly in tissues. Toxicologists traditionally screen for adverse findings by histopathological examination. However, studies of the molecular and cellular processes underpinning toxicological and pathologic findings induced by candidate drugs or toxins are important to reach a mechanistic understanding and an effective risk assessment strategy. One of IMS strengths is the ability to directly overlay the molecular information from the mass spectrometric analysis with the tissue section and allow correlative comparisons of molecular and histologic information. Imaging mass spectrometry could therefore be a powerful tool for omics profiling of pharmacological/toxicological effects of drug candidates and toxicants in discrete tissue regions. The aim of the present review is to provide an overview of imaging mass spectrometry, with particular focus on MALDI imaging mass spectrometry, and its use in drug development and toxicology in general.

Some analytical aspects of the Moessbauer spectrometry

International Nuclear Information System (INIS)

Meisel, W.

1975-01-01

Analytical applications of Moessbauer spectrometry are reviewed. Various methods of analysis (qualitative, semiquantitative and quantitative) using the Moessbauer effect are dealt with. Sensitivity and accuracy of Moessbauer spectrometry in analytical applications are discussed. (Z.S.)

Ambient ionization mass spectrometry

International Nuclear Information System (INIS)

Lebedev, A T

2015-01-01

Ambient ionization mass spectrometry emerged as a new scientific discipline only about ten years ago. A considerable body of information has been reported since that time. Keeping the sensitivity, performance and informativity of classical mass spectrometry methods, the new approach made it possible to eliminate laborious sample preparation procedures and triggered the development of miniaturized instruments to work directly in the field. The review concerns the theoretical foundations and design of ambient ionization methods. Their advantages and drawbacks, as well as prospects for application in chemistry, biology, medicine, environmetal analysis, etc., are discussed. The bibliography includes 194 references

Escatologia e história em Richard Shaull: a narrativa mítico-teológica entre a memória e o futuro

Directory of Open Access Journals (Sweden)

Arnaldo Érico Huff Júnior

2013-01-01

Full Text Available Resumo. O texto pretende pensar a produção da teologia da revolução de Richard Shaull no encontro entre escatologia e história. A partir de um breve relato dos anos de Shaull no Brasil, passa-se à análise das principais ideias teológicas que conduziram Shaull à formulação de uma assim chamada teologia da revolução. Finalmente, propõe-se uma chave interpretativa para a história da teologia, a partir de um diálogo com Reinhart Koselleck e Mircea Eliade.

Determination of radium isotopes in environmental samples by gamma spectrometry, liquid scintillation counting and alpha spectrometry: a review of analytical methodology

International Nuclear Information System (INIS)

Jia, Guogang; Jia, Jing

2012-01-01

Radium (Ra) isotopes are important from the viewpoints of radiation protection and environmental protection. Their high toxicity has stimulated the continuing interest in methodology research for determination of Ra isotopes in various media. In this paper, the three most routinely used analytical techniques for Ra isotope determination in biological and environmental samples, i.e. low-background γ-spectrometry, liquid scintillation counting and α-spectrometry, were reviewed, with emphasis on new methodological developments in sample preparation, preconcentration, separation, purification, source preparation and measurement techniques. The accuracy, selectivity, traceability, applicability and minimum detectable activity (MDA) of the three techniques were discussed. It was concluded that the MDA (0.1 mBq L −1 ) of the α-spectrometry technique coupled with chemical separation is about two orders of magnitude lower than that of low-background HPGe γ-spectrometry and LSC techniques. Therefore, when maximum sensitivity is required, the α-spectrometry technique remains the first choice. - Highlights: ► A review is made for determination of Ra isotopes in environmental samples. ► Gamma spectrometry, LSC and a-spectrometry are the main concerned radiometric approach. ► Sample preparation, preconcentration, separation and source preparation are discussed. ► The methods can analyse air, water, seawater, soil, sediment and foodstuffs samples. ► Some new data obtained recently from our laboratory for Ra method study are included.

Inorganic mass spectrometry of solid samples

International Nuclear Information System (INIS)

Adams, F.; Vertes, A.

1990-01-01

In this review some recent developments in the field of inorganic mass spectrometry of solids are described with special emphasis on the actual state of understanding of the ionization processes. It concentrates on the common characteristics of methods such as spark source-, laser-, secondary ion-, inductively coupled plasma- and glow discharge mass spectrometry. (orig.)

Mass spectrometry in nuclear science and technology

International Nuclear Information System (INIS)

Komori, Takuji

1985-01-01

Mass spectrometry has been widely used and playing a very important role in the field of nuclear science and technology. A major reason for this is that not only the types of element but also its isotopes have to be identified and measured in this field. Thus, some applications of this analytical method are reviewed and discussed in this article. Its application to analytical chemistry is described in the second section following an introductory section, which includes subsections for isotropic dilution mass spectrometry, resonance ionization mass spectrometry and isotopic correlation technique. The isotopic ratio measurement for hydrogen, uranium and plutonium as well as nuclear material control and safeguards are also reviewed in this section. In the third section, mass spectrometry is discussed in relation to nuclear reactors, with subsections on natural uranium reactor and neutron flux observation. Some techniques for measuring the burnup fraction, including the heavy isotopic ratio method and fission product monitoring, are also described. In the fourth section, application of mass spectrometry to measurement of nuclear constants, such as ratio of effective cross-sectional area for 235 U, half-life and fission yield is reviewed. (Nogami, K.)

New trends in nuclear spectrometry

International Nuclear Information System (INIS)

Westmeier, W.; Siemon, K.

2013-01-01

An overview on the status and function of current spectrometry hardware, of detectors having energy-dispersive (spectrometric) properties as well as of the latest developments in quantitative spectrometry software is presented. Making extensive use of modern computing power, new strategies in high-precision spectrum analysis have been developed which enhance the quality of results and also open new fields of spectrometric applications. Three principles have been newly introduced to spectrum analysis software: -use no approximations in modelling (Physics, no numerology) -apply all available models to find a solution (Fuzzy Logic) -repeat complete analyses for iterative improvement (Learn from results). -- Highlights: ► We present an overview of MCA hardware and detectors for nuclear spectrometry. ► Physics-oriented descriptions, Fuzzy Logic and multiple repetitive analyses lead to improved results in spectrum analysis. ► New strategies allow the successful deconvolution of spectra that could not be analysed before

Against the Nihilism of Suffering and Death: Richard E. K. Kim and His Works

Directory of Open Access Journals (Sweden)

Jooyeon Rhee

2016-03-01

Full Text Available This article examines the life and works of Richard E. K. Kim (1932–2009, a first-generation Korean diasporic writer in the United States. It focuses on how Kim struggled to overcome the nihilism of suffering and death that derived from colonialism and the Korean War through his literary works. Kim witnessed firsthand these two major historical events, which caused irrevocable psychological and physical damage to many people of his generation. In his autobiographical fiction, he conveys painful memories of the events by reviving the voices of people in that era. What his works offer us goes beyond vivid memories of the past, however; they also present the power of forgiveness as a condition to overcome the nihilism of suffering and death. Remembrance and forgiveness are, therefore, two major thematic pillars of his works that enable us to connect to these difficult and traumatic times. These themes are portrayed in such a gripping way mainly because Kim tried to maintain a certain distance—an emotional and linguistic distance—from the familiar, in order to elucidate the reality of the human condition: an ontological position of the exile from which he produced his works. This article argues that Kim’s works provide us the possibility to transcend the nihilism of historical trauma through articulating the meaning of remembrance and forgiveness from his self-assumed position of exile.

Mass spectrometry with accelerators.

Science.gov (United States)

Litherland, A E; Zhao, X-L; Kieser, W E

2011-01-01

As one in a series of articles on Canadian contributions to mass spectrometry, this review begins with an outline of the history of accelerator mass spectrometry (AMS), noting roles played by researchers at three Canadian AMS laboratories. After a description of the unique features of AMS, three examples, (14)C, (10)Be, and (129)I are given to illustrate the methods. The capabilities of mass spectrometry have been extended by the addition of atomic isobar selection, molecular isobar attenuation, further ion acceleration, followed by ion detection and ion identification at essentially zero dark current or ion flux. This has been accomplished by exploiting the techniques and accelerators of atomic and nuclear physics. In 1939, the first principles of AMS were established using a cyclotron. In 1977 the selection of isobars in the ion source was established when it was shown that the (14)N(-) ion was very unstable, or extremely difficult to create, making a tandem electrostatic accelerator highly suitable for assisting the mass spectrometric measurement of the rare long-lived radioactive isotope (14)C in the environment. This observation, together with the large attenuation of the molecular isobars (13)CH(-) and (12)CH 2(-) during tandem acceleration and the observed very low background contamination from the ion source, was found to facilitate the mass spectrometry of (14)C to at least a level of (14)C/C ~ 6 × 10(-16), the equivalent of a radiocarbon age of 60,000 years. Tandem Accelerator Mass Spectrometry, or AMS, has now made possible the accurate radiocarbon dating of milligram-sized carbon samples by ion counting as well as dating and tracing with many other long-lived radioactive isotopes such as (10)Be, (26)Al, (36)Cl, and (129)I. The difficulty of obtaining large anion currents with low electron affinities and the difficulties of isobar separation, especially for the heavier mass ions, has prompted the use of molecular anions and the search for alternative

The reliability of the German version of the Richards Campbell Sleep Questionnaire.

Science.gov (United States)

Krotsetis, Susanne; Richards, Kathy C; Behncke, Anja; Köpke, Sascha

2017-07-01

The assessment of sleep quality in critically ill patients is a relevant factor of high-quality care. Despite the fact that sleep disturbances and insufficient sleep management contain an increased risk of severe morbidity for these patients, a translated and applicable instrument to evaluate sleep is not available for German-speaking intensive care settings. This study aimed to translate the Richards Campbell Sleep Questionnaire (RCSQ), a simple and validated instrument eligible for measuring sleep quality in critically ill patients, and subsequently to evaluate the internal consistency of the German version of the RCSQ. Furthermore, it also aimed to inquire into the perception of sleep in a sample of critically ill patients. The RCSQ was translated following established methodological standards. Data were collected cross-sectionally in a sample of 51 patients at 3 intensive care units at a university hospital in Germany. The German version of the RCSQ showed an overall internal consistency (Cronbach's alpha) of 0·88. The mean of the RSCQ in the sample was 47·00 (SD ± 27·57). Depth of sleep was rated the lowest and falling asleep again the highest of the RCSQ sleep items. The study demonstrated very good internal consistency of the German version of the RCSQ, allowing for its application in practice and research in German-speaking countries. Quality of sleep perception was generally low in this sample, emphasizing the need for enhanced care concepts regarding the sleep management of critically ill patients. Relevance to clinical practice Assessment of self-perception of sleep is crucial in order to plan an individually tailored care process. © 2017 British Association of Critical Care Nurses.

Richard Doll and Alice Stewart: reputation and the shaping of scientific "truth".

Science.gov (United States)

Greene, Gayle

2011-01-01

As the world watched the Fukushima reactors release radionuclides into the ocean and atmosphere, the warnings of Dr. Alice Stewart about radiation risk and the reassurances of Sir Richard Doll assumed renewed relevance. Doll and Stewart, pioneer cancer epidemiologists who made major contributions in the 1950s-he by demonstrating the link between lung cancer and smoking, she by discovering that fetal X-rays double the chance of a childhood cancer-were locked into opposition about low-dose radiation risk. When she went public with the discovery that radiation at a fraction of the dose "known" to be dangerous could kill a child, her reputation plummeted, whereas Doll, foremost among her detractors, was knighted and lauded as "the world's most distinguished medical epidemiologist" for his work. Their lives and careers, so closely intertwined, took contrary courses, he becoming "more of the establishment" (as he said), while she became more oppositional. When it was discovered, after his death, that he'd been taking large sums of money from industries whose chemicals he was clearing of cancer risk, his reputation remained unscathed; it is now enshrined in the "Authorized Biography" (2009) commissioned by the Wellcome Institute, along with Doll's denigration of Stewart as an "embittered" woman and biased scientist. Stewart lived long enough to see radiation science move her way, to see international committees affirm, in the 1990s, that there is no threshold beneath which radiation ceases to be dangerous; recent evidence from Chernobyl is bearing out her warnings. But a look at the making and breaking of these reputations reveals the power of status, position, and image to shape scientific "knowledge" and social policy.

The emergence of mass spectrometry in biochemical research

OpenAIRE

1995-01-01

The initial steps toward routinely applying mass spectrometry in the biochemical laboratory have been achieved. In the past, mass spectrometry was confined to the realm of small, relatively stable molecules; large or thermally labile molecules did not survive the desorption and ionization processes intact. Electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry allow for the analysis of both small and large biomolecules through "mild" desorption...

The Road Movies' Space Dynamics in the 70s: Richard C. Sarafian, Monte Hellman and Terrence Malick

Directory of Open Access Journals (Sweden)

Filipa Rosário

2014-07-01

Full Text Available Vanishing Point (Richard C. Sarafian, 1971, Two-lane Blacktop (Monte Hellmann, 1971 and Badlands (Terrence Malick, 1973 are road movies that incorporate distinctive journeys, which, at a certain moment, become similar. Their heroes act as non-mystical pilgrims to whom the trip is a journey in itself, even if they come up as a chase, a car race or an escape from the police.In a filmic genre built from the spatial element, the road life structures each narrative in each film. In this way, the moment when the journey looses its teleological sense acquires even more relevance, allowing us to understand the genre’s space dynamics with a different depth.In this essay, I will analyse comparatively the ways through which characters and directors relate to the scenery/landscape, in order to identify ideological constraints related to space, i.e., those symbolic limitations the road movie seems to conceal. Easy Rider (Dennis Hopper, 1969 will be a constant presence since, as the inaugural road movie, it has determined the genre’s underlying forces.

[Some remarks on the theory of sets by Richard Dedekind and Stanisław Leśniewski].

Science.gov (United States)

Obojska, Lidia

2014-01-01

Mereology, is a part-whole theory, also called the theory of collective sets. It was founded in 1916 by Stanisław Leśniewski and this is an alternative theory versus the classical set theory by Georg Cantor. These two theories are usually teamed up together as Leśniewski himself was referring to the concept of the set by Cantor and Cantor is considered the "main" ideologist of the set theory. However, when analyzing the original texts of various authors, it seems that the very concept of a collective set is closer to the idea of Richard Dedekind rather than that of Georg Cantor. It is known that Cantor borrowed some concepts on the notion of set from Dedekind, whose ideas were also known to Leśniewski, however, there is no study on this topic. This work is therefore an attempt to compare some set-theoretical concepts of both of these authors, i.e. S. Leśiewski and R. Dedekind and the presentation of their convergence.

Emerging mass spectrometry techniques for the direct analysis of microbial colonies

OpenAIRE

Fang, Jinshu; Dorrestein, Pieter C.

2014-01-01

One of the emerging areas in microbiology is detecting specialized metabolites produced by microbial colonies and communities with mass spectrometry. In this review/perspective, we illustrate the emerging mass spectrometry methodologies that enable the interrogation of specialized metabolites directly from microbial colonies. Mass spectrometry techniques such as imaging mass spectrometry and real-time mass spectrometry allow two and three dimensional visualization of the distri...

Mass Spectrometry Analyses of Multicellular Tumor Spheroids.

Science.gov (United States)

Acland, Mitchell; Mittal, Parul; Lokman, Noor A; Klingler-Hoffmann, Manuela; Oehler, Martin K; Hoffmann, Peter

2018-05-01

Multicellular tumor spheroids (MCTS) are a powerful biological in vitro model, which closely mimics the 3D structure of primary avascularized tumors. Mass spectrometry (MS) has established itself as a powerful analytical tool, not only to better understand and describe the complex structure of MCTS, but also to monitor their response to cancer therapeutics. The first part of this review focuses on traditional mass spectrometry approaches with an emphasis on elucidating the molecular characteristics of these structures. Then the mass spectrometry imaging (MSI) approaches used to obtain spatially defined information from MCTS is described. Finally the analysis of primary spheroids, such as those present in ovarian cancer, and the great potential that mass spectrometry analysis of these structures has for improved understanding of cancer progression and for personalized in vitro therapeutic testing is discussed. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Invertendo a “Passagem Atlântica”: O “regresso” de Richard Wright a África

Directory of Open Access Journals (Sweden)

Ana Luísa Saraiva

2012-10-01

Full Text Available O texto discute o sentido polémico do “regresso” a África que Richard Wright inscreve em Black Power e a forma como a narrativa da viagem subverte a “Middle Passage”. O sujeito narrativo orienta o leitor através de uma incursão pessoal nos muitos sentidos da modernidade e desdobra a noção de “destino comum”, já apontada em 12 Million Black Voices. Contudo, qualquer sentido de comunidade é aqui necessariamente ambíguo, por estar sempre relacionado com questões de raça e identidade. Black Power é uma narrativa importante para o conceito de modernidade e assinala uma mudança significativa na produção literária de Wright para uma vertente não-ficcional. Esta segunda fase da sua obra contém, no entanto, um paradoxo crucial: enquanto se volta para o exterior, para o mundo mais global, Wright tenta, simultaneamente, inscrever-se como referência sobre o locus do qual nunca poderia demarcar‑se: África. Em Black Power, a duboisiana “color line” desdobra‑se em múltiplas dimensões.

Health Effects Due to Radionuclides Content of Solid Minerals within Port of Richards Bay, South Africa

Directory of Open Access Journals (Sweden)

Felix B. Masok

2016-11-01

Full Text Available This study assessed the radiological health hazards to various body organs of workers working within Transnet Precinct in Richards Bay in Kwazulu-Natal, South Africa due to radionuclide content of mineral ores often stored within the facility. Thirty samples were collected from five mineral ores (rock phosphate, rutile, zircon, coal and hematite and analyzed for 238U, 234U, 226Ra, 210Pb, 235U, 232Th, 228Ra, 228Th and 40K using delayed neutron activation analysis and low energy gamma spectroscopy. Rutile was found to be the most radioactive mineral ore within the facility with 210Pb concentration of 759.00 ± 106.00 Bq·kg−1. Effective annual dose rate in (mSv·y−1 delivered to different organs of the body: testes, bone marrow, whole body, lungs and ovaries from mineral ores were such that dose from mineral ores decreased in the order coal > rutile > rock phosphate > hematite > zircon. The organs with the highest received dose rate were the testes and this received dose was from coal. However, all of the calculated absorbed dose rates to organs of the body were below the maximum permissible safety limits.

An analysis of nuclear fuel burnup in the AGR-1 TRISO fuel experiment using gamma spectrometry, mass spectrometry, and computational simulation techniques

International Nuclear Information System (INIS)

Harp, Jason M.; Demkowicz, Paul A.; Winston, Philip L.; Sterbentz, James W.

2014-01-01

Highlights: • The burnup of irradiated AGR-1 TRISO fuel was analyzed using gamma spectrometry. • The burnup of irradiated AGR-1 TRISO fuel was also analyzed using mass spectrometry. • Agreement between experimental results and neutron physics simulations was excellent. - Abstract: AGR-1 was the first in a series of experiments designed to test US TRISO fuel under high temperature gas-cooled reactor irradiation conditions. This experiment was irradiated in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) and is currently undergoing post-irradiation examination (PIE) at INL and Oak Ridge National Laboratory. One component of the AGR-1 PIE is the experimental evaluation of the burnup of the fuel by two separate techniques. Gamma spectrometry was used to non-destructively evaluate the burnup of all 72 of the TRISO fuel compacts that comprised the AGR-1 experiment. Two methods for evaluating burnup by gamma spectrometry were developed, one based on the Cs-137 activity and the other based on the ratio of Cs-134 and Cs-137 activities. Burnup values determined from both methods compared well with the values predicted from simulations. The highest measured burnup was 20.1% FIMA (fissions per initial heavy metal atom) for the direct method and 20.0% FIMA for the ratio method (compared to 19.56% FIMA from simulations). An advantage of the ratio method is that the burnup of the cylindrical fuel compacts can be determined in small (2.5 mm) axial increments and an axial burnup profile can be produced. Destructive chemical analysis by inductively coupled mass spectrometry (ICP-MS) was then performed on selected compacts that were representative of the expected range of fuel burnups in the experiment to compare with the burnup values determined by gamma spectrometry. The compacts analyzed by mass spectrometry had a burnup range of 19.3% FIMA to 10.7% FIMA. The mass spectrometry evaluation of burnup for the four compacts agreed well with the gamma

Characterisation of the volatile profiles of infant formulas by proton transfer reaction-mass spectrometry and gas chromatography-mass spectrometry

NARCIS (Netherlands)

Ruth, van S.M.; Floris, V.; Fayoux, S.

2006-01-01

The volatile profiles of 13 infant formulas were evaluated by proton transfer reaction-mass spectrometry (PTR-MS) and gas chromatography¿mass spectrometry (GC¿MS). The infant formulas varied in brand (Aptamil, Cow & Gate, SMA), type (for different infant target groups) and physical form

Who invented the dichotomous key? Richard Waller's watercolors of the herbs of Britain.

Science.gov (United States)

Griffing, Lawrence R

2011-12-01

On 27 March 1689, Richard Waller, Fellow and Secretary of the Royal Society presented his "Tables of the English Herbs reduced to such an order, as to find the name of them by their external figures and shapes" to his assembled colleagues at a meeting of the Royal Society. These tables were developed for the novice by being color images, composed in pencil and watercolor, of selected plants and their distinguishing characteristics. The botanical watercolors for the tables are now a Turning-the-Pages document online on the website of the Royal Society. However, for the past 320 years, the scientific context for the creation of these outstanding botanical watercolors has remained obscure. These tables were developed by Waller as an image-based dichotomous key, pre-dating by almost 100 years the text-based dichotomous keys in the first edition of Flora Française (1778) by Jean Baptiste Lamarck, who is generally given priority for the development of the dichotomous key. How these large folio images were arranged to illustrate a dichotomous key is unknown, but an arrangement based on Waller's description is illustrated here as leaf-ordering for the separate hierarchical clusters (tables). Although only 24 species of watercolored dicot herbs out of a total of 65 in the set of watercolors (the others being monocots) are used in these tables, they are a "proof of concept", serving as models upon which a method is based, that of using a key composed of dichotomous choices for aiding identification.

Application of gamma spectrometry survey and discussion on data processing

International Nuclear Information System (INIS)

Li Ji'an; He Jianguo

2008-01-01

This paper analyzed and discussed the different opinions about the measured parameters of gamma spectrometry data, introduced the effect of gamma spectrometry survey to the search for sandstone type uranium deposit. The author believes that it is very necessary to perform some ground gamma spectrometry survey and enforce the development and application of airborne radiometric data so as to carry out the role of gamma spectrometry in the exploration of sandstone type uranium deposit. (authors)

Mass spectrometry for biomarker development

Energy Technology Data Exchange (ETDEWEB)

Wu, Chaochao; Liu, Tao; Baker, Erin Shammel; Rodland, Karin D.; Smith, Richard D.

2015-06-19

Biomarkers potentially play a crucial role in early disease diagnosis, prognosis and targeted therapy. In the past decade, mass spectrometry based proteomics has become increasingly important in biomarker development due to large advances in technology and associated methods. This chapter mainly focuses on the application of broad (e.g. shotgun) proteomics in biomarker discovery and the utility of targeted proteomics in biomarker verification and validation. A range of mass spectrometry methodologies are discussed emphasizing their efficacy in the different stages in biomarker development, with a particular emphasis on blood biomarker development.

Determination of plutonium-238 in plutonium by alpha spectrometry

International Nuclear Information System (INIS)

Aggarwal, S.K.; Jain, H.C.; Mathews, C.K.; Ramaniah, M.V.

1975-01-01

A method is presented for the determination of 238 Pu in plutonium samples by alpha spectrometry. Various factors attributing towards the energy degradation, a problem usually encountered in alpha spectrometry, are discussed. A computer programme is given for the evaluation of peak areas when the alpha spectrum is degraded. The results are compared with those obtained by mass spectrometry. (author)

Tandem mass spectrometry at low kinetic energy

International Nuclear Information System (INIS)

Cooks, R.G.; Hand, O.W.

1987-01-01

Recent progress in mass spectrometry, as applied to molecular analysis, is reviewed with emphasis on tandem mass spectrometry. Tandem instruments use multiple analyzers (sector magnets, quadrupole mass filters and time-of-flight devices) to select particular molecules in ionic form, react them in the gas-phase and then record the mass, momenta or kinetic energies of their products. The capabilities of tandem mass spectrometry for identification of individual molecules or particular classes of compounds in complex mixtures are illustrated. Several different types of experiments can be run using a tandem mass spectrometer; all share the feature of sifting the molecular mixture being analyzed on the basis of chemical properties expressed in terms of ionic mass, kinetic energy or charge state. Applications of mass spectrometry to biological problems often depend upon desorption methods of ionization in which samples are bombarded with particle beams. Evaporation of preformed charged species from the condensed phase into the vacuum is a particularly effective method of ionization. It is suggested that the use of accelerator mass spectrometers be extended to include problems of molecular analysis. In such experiments, low energy tandem mass spectrometry conducted in the eV or keV range of energies, would be followed by further characterization of the production ion beam using high selective MeV collision processes

Morrow, Reiff, Receive 2013 Space Physics and Aeronomy Richard Carrington Awards: Response

Science.gov (United States)

Reiff, Patricia H.

2014-08-01

It is a special privilege to receive this award honoring Richard Carrington's discovery of what we now call space weather. It is particularly appropriate that this award also recognizes Cherilynn Morrow, who 20 years ago made a presentation to the Space Science Advisory Committee on Jeff Rosendhal's idea of mission-based E/PO. We worked together, bringing that idea to the successful, but threatened, network it is today. For me, learning and teaching go hand in hand—as we publish our findings for our peers, we should also repay the public investment in our research with accurate, understandable results. My interest in space science was sparked by a father-daughter course in astronomy sponsored by the Brownies at the Oklahoma City Planetarium and kindled by the Bell Labs production The Strange Case of the Cosmic Rays directed by Frank Capra. Knowing that planetarium shows and educational movies can change lives, I have devoted a large portion of my last 25 years to creating software, shows, and portable planetariums to inspire and engage youth. This has not been a one-person effort, of course. My work Cherilynn Ann Morrow would have been impossible without the collaboration of Carolyn Sumners, vice president of the Houston Museum of Natural Science. Our museum kiosk and planetarium control software would not have happened without the skill and perseverance of my chief programmer, Colin Law. Jim Burch has been first a mentor and then a colleague on both the research and outreach sides of my career. I share this honor with a long line of highly talented students and postdocs who have contributed science content and outreach efforts. Most importantly, without the support of my husband, Tom Hill, I would not have had the time and freedom to build an educational network while continuing research and raising a family. I thank AGU for bestowing this honor.

Timothy Leary, Richard Alpert (Ram Dass) and the changing definition of psilocybin.

Science.gov (United States)

Wark, Colin; Galliher, John F

2010-05-01

This research focuses on the events leading to the 1968 U.S. federal prohibition of psilocybin. It is a study of duelling moral entrepreneurs-Timothy Leary and Richard Alpert vs. the Harvard University Administration. The goal is to show how the primary active compound in an ostensibly harmless fungus (the psilocybin mushroom) became controversial in less than a decade. We used books, newspapers, magazine articles and previously unpublished materials (including documents from the Harvard Archives) to analyze Leary and Alpert's lives and careers through the early 1970s. The prohibition of psilocybin in the U.S. was largely a product of Leary and Alpert's involvement in the "Harvard drug scandal" and their transformation from Harvard professors to countercultural icons. They tested the substance on a variety of human subjects and in doing so piqued the interest of Harvard undergraduates while drawing condemnation from other faculty and Harvard administrators. This case is theoretically interesting because unlike most illegal drugs, psilocybin was never linked to a threatening minority group, but to some of the nation's most privileged youth. The Harvard administrators were not really moral entrepreneurs but Leary and Alpert clearly were. Although they were far from being prohibitionists, they were self-righteous crusaders on different but equally holy missions for the good of young and minority Americans. Ironically, due to their successes the possession of psilocybin was criminalized under United States federal law in 1968 (Pub. L. No. 90-639, Stat. 1361 1968 and Boire, 2002). This case study demonstrates that crusaders can be successful in changing culture even when laws are passed in futile attempts to control their behaviour, just as Leary predicted. Copyright 2009 Elsevier B.V. All rights reserved.

Metrological characterization of the numerical system Adonis for gamma spectrometry; Caracterisation metrologique du systeme de spectrometrie gamma numerique Adonis

Energy Technology Data Exchange (ETDEWEB)

Plagnard, J.; Morel, J.; Tran Tuan, A

2005-07-01

In gamma spectrometry, new acquisition systems based on digital processing of the signals are now available on the market. In order to determine their performances at high count rates, The CEA-LNHB (Commissariat a l'Energie Atomique - Laboratoire National Henri Becquerel) has tested several of these equipments.. These tests have clearly shown that the performances announced by the manufacturers were generally not met. At this point, it was interesting to include in these tests, the system ADONIS (Atelier de Developpement Numerique pour l'Instrumentation en Spectrometrie), which is the new gamma spectrometry system, developed by the CEA-SIAR (Service d'Instrumentation et d'Application des Rayonnements). (authors)

Programmer for automatic gamma spectrometry; Ordonnateur de sequence pour spectrometrie gamma automatique

Energy Technology Data Exchange (ETDEWEB)

Romanetti, R [Commissariat a l' Energie Atomique, Cadarache (France). Centre d' Etudes Nucleaires

1968-04-01

With this apparatus, which is constructed of logical integrated circuits, it is possible both to synchronize an automatic gamma spectrometry assembly and to record the spectra on punched cards. An IBM terminal will make it possible with the help of analysis by the least squares method and by a direct dialogue with an IBM 360 computer to obtain analytical results almost instantaneously. (author) [French] Cet appareil, realise en circuits integres logiques, permet d'une part de synchroniser un ensemble automatique de spectrometrie gamma et d'autre part d'enregistrer les spectres sur cartes perforees. Un terminal IBM permettra, a l'aide d'un programme d'analyse par la methode des moindres carres et par un dialogue direct avec un ordinateur IBM 360, de disposer presque intanstanement des resultats des analyses. (auteur)

Perbandingan antara Etika Jürgen Habermas dan Richard Rorty sebagai Prinsip Dasar Bertindak Manusia

Directory of Open Access Journals (Sweden)

Dominique Rio Adiwijaya

2010-10-01

Full Text Available Ethics without doubt is an issue in every scientific field. Questions on ethics are not merely questions on the responsibility of one or two specific individuals, but rather as what have been defined accurately by Immanuel Kant in Critique of Practical Reason – as question of all humanity as a thinking creature and the freedom of choice on, “what should I do”. From Kant’s definition, we may infer that if human can not think and not free in determining their choice, it would be almost impossible to hope for moral responsibility. However this article does not mean to give a full and historical description on ethics, but a sketch on discourse of contemporary ethics which is represented by two famous philosophers, Jürgen Habermas from the tradition of  Critical Theory from Frankfurt School, dan Richard Rorty with “Neo-Pragmatism”. Habermas proposes “discourse ethics” while Rorty proposes ethic concepts through his “liberal-ironists”. It is hoped that the assembly of readers may gain an insight of the unavoidable ethics problems since every ethical position must be theory laden and the theory itself has historical characteristics (the characteristics, origin and historical context of the schools behind it. Therefore ethics is a neverending reflection although it has been started from 2500 years ago. Ethics invites us from specific sciences to enter its general discourse which unavoidably all-encompassing in its nature. 

Mass spectrometry in life science research.

Science.gov (United States)

Lehr, Stefan; Markgraf, Daniel

2016-12-01

Investigating complex signatures of biomolecules by mass spectrometry approaches has become indispensable in molecular life science research. Nowadays, various mass spectrometry-based omics technologies are available to monitor qualitative and quantitative changes within hundreds or thousands of biological active components, including proteins/peptides, lipids and metabolites. These comprehensive investigations have the potential to decipher the pathophysiology of disease development at a molecular level and to monitor the individual response of pharmacological treatment or lifestyle intervention.

‘The Edification of the Church’: Richard Hooker’s Theology of Worship and the Protestant Inward / Outward Disjunction

Directory of Open Access Journals (Sweden)

Littlejohn W. Bradford

2014-06-01

Full Text Available Sixteenth-century English Protestants struggled with the legacy left them by the Lutheran reformation: a strict disjunction between inward and outward that hindered the development of a robust theology of worship. For Luther, outward forms of worship had more to do with the edification of the neighbour than they did with pleasing God. But what exactly did ‘edification’ mean? On the one hand, English Protestants sought to avoid the Roman Catholic view that certain elements of worship held an intrinsic spiritual value; on the other hand, many did not want to imply that forms of worship were spiritually arbitrary and had a merely civil value. Richard Hooker developed his theology of worship in response to this challenge, seeking to maintain a clear distinction between the inward worship of the heart and the outward forms of public worship, while refusing to disassociate the two. The result was a concept of edification which sought to do justice to both civil and spiritual concerns, without, pace Peter Lake and other scholars, conceding an inch to a Catholic theology of worship

[Latest development in mass spectrometry for clinical application].

Science.gov (United States)

Takino, Masahiko

2013-09-01

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has seen enormous growth in special clinical chemistry laboratories. It significantly increases the analytic potential in clinical chemistry, especially in the field of low molecular weight biomarker analysis. This review summarizes the state of the art in mass spectrometry and related techniques for clinical application with a main focus on recent developments in LC-MS. Current trends in ionization techniques, automated online sample preparation techniques coupled with LC-MS, and ion mobility spectrometry are discussed. Emerging mass spectrometric approaches complementary to LC-MS are discussed as well.

Blood, politics, and social science. Richard Titmuss and the Institute of Economic Affairs, 1957-1973.

Science.gov (United States)

Fontaine, Philippe

2002-09-01

Long before his last book, The Gift Relationship: From Human Blood to Social Policy, was published in early 1971, Richard M. Titmuss (1907-1973), a professor of social administration at the London School of Economics, had been a major figure in the debates over the welfare state. The Gift Relationship was the culmination of an eventful relationship with the Institute of Economic Affairs, a think tank that advocated the extension of rational pricing to social services. By arguing that the British system of blood procurement and distribution, based on free giving within the National Health Service, was more efficient than the partly commercialized American system, Titmuss intended to signal the dangers of the increasing commercialization of society. What made for the impact of his book, however, was not merely its argument that transfusion-transmitted infections were much more common with paid than with voluntary donors, but also its reflections on what it is that holds a society together. And here Titmuss argued that a "socialist" social policy, by encouraging the sense of community, played a central role. The eclecticism of Titmuss's work, together with its strong ethical and political flavor, makes it a rich and original account of the "social" at a time when heated debated over social policy, both in Britain and in the United States, raised the question of the division of labor among the social sciences.

Mass spectrometry for real-time quantitative breath analysis

Czech Academy of Sciences Publication Activity Database

Smith, D.; Španěl, Patrik; Herbig, J.; Beauchamp, J.

2014-01-01

Roč. 8, č. 2 (2014), 027101 ISSN 1752-7155 Institutional support: RVO:61388955 Keywords : breath analysis * proton transfer reaction mass spectrometry * selected ion flow tube mass spectrometry Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 4.631, year: 2014

Improving Ion Mobility Spectrometry Detection Methods for Trace Forensics and Military Field Applications

Science.gov (United States)

2016-10-11

You have helped develop my personal skills to that will benefit DoD, government and civilian organizations. I pray our two institutions will...explosion onboard Philippine Airlines flight 200 in 1994 91 and the 2003 “shoe-bomber” incident where Richard Reid’s hiking boots were found to be...heated columns has also shown to be equivalent to that obtained with standard GC air circulation laboratory instruments.66 Additional benefits of

Sampling and analyte enrichment strategies for ambient mass spectrometry.

Science.gov (United States)

Li, Xianjiang; Ma, Wen; Li, Hongmei; Ai, Wanpeng; Bai, Yu; Liu, Huwei

2018-01-01

Ambient mass spectrometry provides great convenience for fast screening, and has showed promising potential in analytical chemistry. However, its relatively low sensitivity seriously restricts its practical utility in trace compound analysis. In this review, we summarize the sampling and analyte enrichment strategies coupled with nine modes of representative ambient mass spectrometry (desorption electrospray ionization, paper vhspray ionization, wooden-tip spray ionization, probe electrospray ionization, coated blade spray ionization, direct analysis in real time, desorption corona beam ionization, dielectric barrier discharge ionization, and atmospheric-pressure solids analysis probe) that have dramatically increased the detection sensitivity. We believe that these advances will promote routine use of ambient mass spectrometry. Graphical abstract Scheme of sampling stretagies for ambient mass spectrometry.

[Imaging Mass Spectrometry in Histopathologic Analysis].

Science.gov (United States)

Yamazaki, Fumiyoshi; Seto, Mitsutoshi

2015-04-01

Matrix-assisted laser desorption/ionization (MALDI)-imaging mass spectrometry (IMS) enables visualization of the distribution of a range of biomolecules by integrating biochemical information from mass spectrometry with positional information from microscopy. IMS identifies a target molecule. In addition, IMS enables global analysis of biomolecules containing unknown molecules by detecting the ratio of the molecular weight to electric charge without any target, which makes it possible to identify novel molecules. IMS generates data on the distribution of lipids and small molecules in tissues, which is difficult to visualize with either conventional counter-staining or immunohistochemistry. In this review, we firstly introduce the principle of imaging mass spectrometry and recent advances in the sample preparation method. Secondly, we present findings regarding biological samples, especially pathological ones. Finally, we discuss the limitations and problems of the IMS technique and clinical application, such as in drug development.

The allure of mass spectrometry: From an earlyday chemist's perspective.

Science.gov (United States)

Tőkés, László

2017-07-01

This reminiscing review article is an account of the author's fascination and involvements with mass spectrometry from the perspective of an organic chemist with an interest in natural product chemistry. It covers a period from 1961 through the mid 1990s as mass spectrometry evolved form a novelty technique to become a most widely used analytical technique. Following a brief synopsis of my pathway to mass spectrometry, my research efforts in this field are presented with a focus mainly on evolving principles and technologies which I had personal involvements with. To provide historical perspectives, discussions of these developments are accompanied by brief outlines of the relevant state-of-the-art, shedding light on the technical and conceptual challenges encountered during those early days in mass spectrometry. Examples are presented of my involvements with basic and applied research in mass spectrometry during graduate studies at Stanford University and close to three decade tenure in pharmaceutical research at Syntex Research. My basic research interests focused mainly on principles of electron ionization induced fragmentation mechanisms, with an emphasis on steroids and other model compounds. Extensive deuterium labeling evidence was used to determine the fragmentation mechanisms of the diagnostically significant ions in the spectra of numerous model compounds, uncovering examples of wide-ranging hydrogen transfers, skeletal rearrangements, methyl and phenyl migrations, stereoselective fragmentations and low and high energy fragmentation processes. Depiction of the industrial research phase of my career includes comments on the pivotal role mass spectrometry played on advancing modern pharmaceutical research. Examples are presented of involvements with instrumental developments and a few select cases of applied research, including studies of bile mechanisms in vertebrates, identification of bisphenol-A leaching from sterilized polycarbonate containers, high

High-field asymmetric waveform ion mobility spectrometry for mass spectrometry-based proteomics.

Science.gov (United States)

Swearingen, Kristian E; Moritz, Robert L

2012-10-01

High-field asymmetric waveform ion mobility spectrometry (FAIMS) is an atmospheric pressure ion mobility technique that separates gas-phase ions by their behavior in strong and weak electric fields. FAIMS is easily interfaced with electrospray ionization and has been implemented as an additional separation mode between liquid chromatography (LC) and mass spectrometry (MS) in proteomic studies. FAIMS separation is orthogonal to both LC and MS and is used as a means of on-line fractionation to improve the detection of peptides in complex samples. FAIMS improves dynamic range and concomitantly the detection limits of ions by filtering out chemical noise. FAIMS can also be used to remove interfering ion species and to select peptide charge states optimal for identification by tandem MS. Here, the authors review recent developments in LC-FAIMS-MS and its application to MS-based proteomics.

Statistical methods for mass spectrometry-based clinical proteomics

NARCIS (Netherlands)

Kakourou, A.

2018-01-01

The work presented in this thesis focuses on methods for the construction of diagnostic rules based on clinical mass spectrometry proteomic data. Mass spectrometry has become one of the key technologies for jointly measuring the expression of thousands of proteins in biological samples.

Reliability of graphite furnace atomic absorption spectrometry as ...

African Journals Online (AJOL)

Purpose: To evaluate the comparative efficiency of graphite furnace atomic absorption spectrometry (GFAAS) and hydride generation atomic absorption spectrometry (HGAAS) for trace analysis of arsenic (As) in natural herbal products (NHPs). Method: Arsenic analysis in natural herbal products and standard reference ...

Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses

Science.gov (United States)

Zheng, Xueyun; Wojcik, Roza; Zhang, Xing; Ibrahim, Yehia M.; Burnum-Johnson, Kristin E.; Orton, Daniel J.; Monroe, Matthew E.; Moore, Ronald J.; Smith, Richard D.; Baker, Erin S.

2017-01-01

Ion mobility spectrometry (IMS) is a widely used analytical technique for rapid molecular separations in the gas phase. Though IMS alone is useful, its coupling with mass spectrometry (MS) and front-end separations is extremely beneficial for increasing measurement sensitivity, peak capacity of complex mixtures, and the scope of molecular information available from biological and environmental sample analyses. In fact, multiple disease screening and environmental evaluations have illustrated that the IMS-based multidimensional separations extract information that cannot be acquired with each technique individually. This review highlights three-dimensional separations using IMS-MS in conjunction with a range of front-end techniques, such as gas chromatography, supercritical fluid chromatography, liquid chromatography, solid-phase extractions, capillary electrophoresis, field asymmetric ion mobility spectrometry, and microfluidic devices. The origination, current state, various applications, and future capabilities of these multidimensional approaches are described in detail to provide insight into their uses and benefits. PMID:28301728

Gamma spectrometry of infinite 4Π geometry

International Nuclear Information System (INIS)

Nordemann, D.J.R.

1987-07-01

Owing to the weak absorption og gamma radiation by matter, gamma-ray spectrometry may be applied to samples of great volume. A very interesting case is that of the gamma-ray spectrometry applied with 4Π geometry around the detector on a sample assumed to be of infinite extension. The determination of suitable efficiencies allows this method to be quantitative. (author) [pt

Urban gamma spectrometry. Report 2

Energy Technology Data Exchange (ETDEWEB)

Aage, H.K. (Technical Univ. of Denmark, Kgs. Lyngby (Denmark)); Kuukankorpi, S.; Moring, M.; Smolander, P.; Toivonen, H. (Radiation and Nuclear Safety Authority, Helsinki (Finland))

2009-06-15

Urban gamma spectrometry has been given only minor attention with the focus being on rural gamma spectrometry. However, in recent years the Nordic emergency management authorities have turned focus towards border control and lost or stolen sources. Gamma spectra measured in urban areas are characterized by a wide variety of spectrum shapes and very fast changes in environmental background. In 2004 a Danish CGS (Carborne Gamma Spectrometry) survey took place in Copenhagen. It was found that gamma spectrometry in urban areas is far more complicated to interpret than had previously been thought and a new method 'Fitting with Spectral Components', FSC, based on NASVD, was tested with some success. In Finland, a database 'LINSSI' has been developed for spectral data management. In CGS search mode a 'peak hypothesis test' is applied to the measured spectra. This system was tested during the Helsinki 2005 Athletics World Championship and it provides fast and reliable automated alarms for intermediate and high level signals. In Sweden mobile detector systems are used for border controls and problems are encountered when making measurement in harbour, container areas. The methods for handling data and for interpretation of urban gamma spectrometry measurements were compared and tested on the same data sets from Copenhagen and Helsinki. Software tools were developed for converting data between the Finnish LINSSI database and the binary file formats used in Denmark and Sweden. The Processing methods used at DTU and STUK have different goals. The ASSS and FSC methods are designed to optimize the overall detection capability of the system, while sacrificing speed, usability and to a certain level robustness. These methods cannot always be used for real time analysis. The Peak Significance method is designed to give robust alarms in real time, while sacrificing some of the detection capability. Thus these methods are not interchangeable, but rather

Urban gamma spectrometry. Report 2

International Nuclear Information System (INIS)

Aage, H.K.; Kuukankorpi, S.; Moring, M.; Smolander, P.; Toivonen, H.

2009-06-01

Urban gamma spectrometry has been given only minor attention with the focus being on rural gamma spectrometry. However, in recent years the Nordic emergency management authorities have turned focus towards border control and lost or stolen sources. Gamma spectra measured in urban areas are characterized by a wide variety of spectrum shapes and very fast changes in environmental background. In 2004 a Danish CGS (Carborne Gamma Spectrometry) survey took place in Copenhagen. It was found that gamma spectrometry in urban areas is far more complicated to interpret than had previously been thought and a new method 'Fitting with Spectral Components', FSC, based on NASVD, was tested with some success. In Finland, a database 'LINSSI' has been developed for spectral data management. In CGS search mode a 'peak hypothesis test' is applied to the measured spectra. This system was tested during the Helsinki 2005 Athletics World Championship and it provides fast and reliable automated alarms for intermediate and high level signals. In Sweden mobile detector systems are used for border controls and problems are encountered when making measurement in harbour, container areas. The methods for handling data and for interpretation of urban gamma spectrometry measurements were compared and tested on the same data sets from Copenhagen and Helsinki. Software tools were developed for converting data between the Finnish LINSSI database and the binary file formats used in Denmark and Sweden. The Processing methods used at DTU and STUK have different goals. The ASSS and FSC methods are designed to optimize the overall detection capability of the system, while sacrificing speed, usability and to a certain level robustness. These methods cannot always be used for real time analysis. The Peak Significance method is designed to give robust alarms in real time, while sacrificing some of the detection capability. Thus these methods are not interchangeable, but rather complementary. An ideal system

Atomic Absorption, Atomic Fluorescence, and Flame Emission Spectrometry.

Science.gov (United States)

Horlick, Gary

1984-01-01

This review is presented in six sections. Sections focus on literature related to: (1) developments in instrumentation, measurement techniques, and procedures; (2) performance studies of flames and electrothermal atomizers; (3) applications of atomic absorption spectrometry; (4) analytical comparisons; (5) atomic fluorescence spectrometry; and (6)…

X-ray spectrometry with synchrotron radiation; Roentgenspektrometrie mit Synchrotronstrahlung

Energy Technology Data Exchange (ETDEWEB)

Mueller, Matthias [Physikalisch-Technische Bundesanstalt (PTB), Berlin (Germany). Arbeitsgruppe ' Roentgen- und IR-Spektrometrie' ; Gerlach, Martin; Holfelder, Ina; Hoenicke, Philipp; Lubeck, Janin; Nutsch, Andreas; Pollakowski, Beatrix; Streeck, Cornelia; Unterumsberger, Rainer; Weser, Jan; Beckhoff, Burkhard

2014-12-15

The X-ray spectrometry of the PTB at the BESSY II storage ring with radiation in the range from 78 eV to 10.5 keV is described. After a description of the instrumentation development reference-sample free X-ray fluorescence analysis, the determination of fundamental atomic parameters, X-ray fluorescence analysis under glance-angle incidence, highly-resolving absorption spectrometry, and emission spectrometry are considered. Finally liquid cells and in-situ measurement techniques are described. (HSI)

Review of Richard Parra, «La tiranía del Inca. El Inca Garcilaso y la escritura política en el Perú colonial (1568-1617», Lima, Ediciones Copé, 2015, 508 pp., ISBN 978-6124-20-221-6

Directory of Open Access Journals (Sweden)

Germán Adolfo Morong Reyes

2016-05-01

Full Text Available Review of Richard Parra, «La tiranía del Inca. El Inca Garcilaso y la escritura política en el Perú colonial (1568-1617», Lima, Ediciones Copé, 2015, 508 pp., ISBN 978-6124-20-221-6

A history of mass spectrometry in Australia

Energy Technology Data Exchange (ETDEWEB)

Downard, K.M.; de Laeter, J.R. [University of Sydney, Sydney, NSW (Australia)

2005-09-01

An interest in mass spectrometry in Australia can be traced back to the 1920s with an early correspondence with Francis Aston who first visited these shores a decade earlier. The region has a rich tradition in both the development of the field and its application, from early measurements of ionization and appearance potentials by Jim Morrison at the Council for Scientific and Industrial Research (CSIR) around 1950 to the design and construction of instrumentation including the first use of a triple quadrupole mass spectrometer for tandem mass spectrometry, the first suite of programs to simulate ion optics (SIMION), the development of early TOF/TOF instruments and orthogonal acceleration and the local design and construction of several generations of a sensitive high-resolution ion microprobe (SHRIMP) instrument. Mass spectrometry has been exploited in the study and characterization of the constituents of this nation's unique flora and fauna from Australian apples, honey, tea plant and eucalyptus oil, snake, spider, fish and frog venoms, coal, oil, sediments and shale, environmental studies of groundwater to geochronological dating of limestone and granite, other terrestrial and meteoritic rocks and coral from the Great Barrier Reef. This article traces the history of mass spectrometry in its many guises and applications in the island continent of Australia. It focuses on contributions of scientists who played a major role in the early establishment of mass spectrometry in Australia. In general, those who are presently active in the field, and whose histories are incomplete, have been mentioned at best only briefly despite their important contributions to the field.

Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses

Energy Technology Data Exchange (ETDEWEB)

Zheng, Xueyun; Wojcik, Roza; Zhang, Xing; Ibrahim, Yehia M.; Burnum-Johnson, Kristin E.; Orton, Daniel J.; Monroe, Matthew E.; Moore, Ronald J.; Smith, Richard D.; Baker, Erin M.

2017-06-12

Ion mobility spectrometry (IMS) is a widely used analytical technique for rapid molecular separations in the gas phase. IMS alone is useful, but its coupling with mass spectrometry (MS) and front-end separations has been extremely beneficial for increasing measurement sensitivity, peak capacity of complex mixtures, and the scope of molecular information in biological and environmental sample analyses. Multiple studies in disease screening and environmental evaluations have even shown these IMS-based multidimensional separations extract information not possible with each technique individually. This review highlights 3-dimensional separations using IMS-MS in conjunction with a range of front-end techniques, such as gas chromatography (GC), supercritical fluid chromatography (SFC), liquid chromatography (LC), solid phase extractions (SPE), capillary electrophoresis (CE), field asymmetric ion mobility spectrometry (FAIMS), and microfluidic devices. The origination, current state, various applications, and future capabilities for these multidimensional approaches are described to provide insight into the utility and potential of each technique.

Statistical analysis of proteomics, metabolomics, and lipidomics data using mass spectrometry

CERN Document Server

Mertens, Bart

2017-01-01

This book presents an overview of computational and statistical design and analysis of mass spectrometry-based proteomics, metabolomics, and lipidomics data. This contributed volume provides an introduction to the special aspects of statistical design and analysis with mass spectrometry data for the new omic sciences. The text discusses common aspects of design and analysis between and across all (or most) forms of mass spectrometry, while also providing special examples of application with the most common forms of mass spectrometry. Also covered are applications of computational mass spectrometry not only in clinical study but also in the interpretation of omics data in plant biology studies. Omics research fields are expected to revolutionize biomolecular research by the ability to simultaneously profile many compounds within either patient blood, urine, tissue, or other biological samples. Mass spectrometry is one of the key analytical techniques used in these new omic sciences. Liquid chromatography mass ...

Analysis of Nitro-aromatic and Nitramine Explosives by Atmospheric Pressure Chemical Ionization / High Performance Liquid Chromatography / Mass Spectrometry / Mass Spectrometry

International Nuclear Information System (INIS)

Hicks, B.J.; Han, W.; Robben, J.R.

2009-01-01

This procedure is capable of separating and quantifying twenty-nine high explosives and internal surrogates with a single injection. After the initial preparation step, the sample is introduced to the high performance liquid chromatograph for target separation, ionized by atmospheric pressure chemical ionization and the explosives of interest are isolated / quantified by mass spectrometry / mass spectrometry. Concentrations of the target explosives are measured relative to the response of both internal and external standard concentrations. A C-18 reverse phase high performance liquid chromatograph column is used for separation. Ionization is performed using both positive and negative atmospheric pressure chemical ionization resulting in a molecular ion with little fragmentation. These ions are isolated at the first quadrupole of the mass spectrometer, dissociated by collision with argon in the collision cell and the resulting daughter ions are isolated at the second quadrupole. These daughter ions then reach the detector where they are quantified. To date this procedure represents the most thorough high performance liquid chromatography / mass spectrometry / mass spectrometry explosives analysis available in the environmental chemistry market. (authors)

Plant trait detection with multi-scale spectrometry

Science.gov (United States)

Gamon, J. A.; Wang, R.

2017-12-01

Proximal and remote sensing using imaging spectrometry offers new opportunities for detecting plant traits, with benefits for phenotyping, productivity estimation, stress detection, and biodiversity studies. Using proximal and airborne spectrometry, we evaluated variation in plant optical properties at various spatial and spectral scales with the goal of identifying optimal scales for distinguishing plant traits related to photosynthetic function. Using directed approaches based on physiological vegetation indices, and statistical approaches based on spectral information content, we explored alternate ways of distinguishing plant traits with imaging spectrometry. With both leaf traits and canopy structure contributing to the signals, results exhibit a strong scale dependence. Our results demonstrate the benefits of multi-scale experimental approaches within a clear conceptual framework when applying remote sensing methods to plant trait detection for phenotyping, productivity, and biodiversity studies.

Trends in preconcentration procedures for metal determination using atomic spectrometry techniques

International Nuclear Information System (INIS)

Godoi Pereira, M. de; Arruda, M.A.Z.

2003-01-01

Methods for metal preconcentration are often described in the literature. However, purposes are often different, depending on whether the methods are applied in environmental, clinical or technological fields. The respective method needs to be efficient, give high sensitivity, and ideally also is selective which is useful when used in combination with atomic spectroscopy. This review presents the actual tendencies in metal preconcentration using techniques such as flame atomic absorption spectrometry (FAAS), electrothermal atomic absorption spectrometry (ETAAS), hydride generation atomic absorption spectrometry (HGAAS), inductively coupled plasma optical emission spectrometry (ICP OES) and inductively coupled plasma mass spectrometry (ICP-MS). Procedures based on related to electrochemical, coprecipitation/precipitation, liquid-liquid and solid-liquid extraction and atom trapping mechanisms are presented. (author)

Derivative flame atomic absorption spectrometry and its application in trace analysis

International Nuclear Information System (INIS)

Sun, H. W.; Li, L. Q.

2005-01-01

Flame atomic absorption spectrometry is an accepted and widely used method for the determination of trace elements in a great variety of samples. But its sensitivity doesn't meet the demands of trace and ultra-trace analysis for some samples. The derivative signal processing technique, with a very high capability for enhancing sensitivity, was developed for flame atomic absorption spectrometry. The signal models of conventional flame atomic absorption spectrometry are described. The equations of derivative signals are established for flame atomic absorption spectrometry, flow injection atomic absorption spectrometry (FI-FAAS) and atom trapping flame atomic absorption spectrometry (AT-FAAS). The principle and performance of the derivative atomic absorption spectrometry are evaluated. The derivative technique based on determination of variation rate of signal intensity with time (dl/dt) is different from the derivative spectrophotometry based on determination of variation rate of signal intensity with wavelength (dl/dhλ). Derivative flame atomic absorption spectrometry has higher sensitivity, lower detection limits and better accuracy. It has been applied to the direct determination of trace elements without preconcentration. If the derivative technique was combined with several preconcentration techniques, the sensitivity would be enhanced further for ultra-trace analysis with good linearity. The applications of derivative flame atomic absorption spectroscopy are reviewed for trace element analysis in biological, pharmaceutical, environmental and food samples

Mass spectrometry for characterizing plant cell wall polysaccharides

Directory of Open Access Journals (Sweden)

Stefan eBauer

2012-03-01

Full Text Available Mass spectrometry is a selective and powerful technique to obtain identification and structural information on compounds present in complex mixtures. Since it requires only small sample amount it is an excellent tool for researchers interested in detecting changes in composition of complex carbohydrates of plants. This mini-review gives an overview of common mass spectrometry techniques applied to the analysis of plant cell wall carbohydrates. It presents examples in which mass spectrometry has been used to elucidate the structure of oligosaccharides derived from hemicelluloses and pectins and illustrates how information on sequence, linkages, branching and modifications are obtained from characteristic fragmentation patterns.

Flow injection analysis in inductively coupled plasma spectrometry

International Nuclear Information System (INIS)

Rosias, Maria F.G.G.

1995-10-01

The main features of flow injection analysis (FIA) as contribution to the inductively coupled plasma (Icp) spectrometry are described. A systematic review of researches using the combined FIA-Icp and the benefits of this association are presented. Flow systems were proposed to perform on-line Icp solution management for multielemental determination by atomic emission spectrometry (Icp-AES) or mass spectrometry. The inclusion of on-line ion exchangers in flow systems for matrix separation and/or analyte preconcentration are presented. Together with those applications the new advent of instruments with facilities for multielement detection on flow injection signals are described. (author). 75 refs., 19 figs

Proteomic Mass Spectrometry Imaging for Skin Cancer Diagnosis.

Science.gov (United States)

Lazova, Rossitza; Seeley, Erin H

2017-10-01

Mass spectrometry imaging can be successfully used for skin cancer diagnosis, particularly for the diagnosis of challenging melanocytic lesions. This method analyzes proteins within benign and malignant melanocytic tumor cells and, based on their differences, which constitute a unique molecular signature of 5 to 20 proteins, can render a diagnosis of benign nevus versus malignant melanoma. Mass spectrometry imaging may assist in the differentiation between metastases and nevi as well as between proliferative nodules in nevi and melanoma arising in a nevus. In the difficult area of atypical Spitzoid neoplasms, mass spectrometry diagnosis can predict clinical outcome better than histopathology. Copyright © 2017 Elsevier Inc. All rights reserved.

Time domain optical spectrometry with fiber optic waveguides

International Nuclear Information System (INIS)

Whitten, W.B.

1983-01-01

Spectrometers which use optical fibers to obtain time domain spectral dispersion are reviewed. Pulse transmission through fiber optic waveguides is discussed and the basic requirements for sources and detectors are given. Multiplex spectrometry and time-of-flight spectrometry are then discussed. Resolution, fiber requirements, instrumentation and specific spectrometers are presented

X-ray fluorescence spectrometry

International Nuclear Information System (INIS)

Ray, N.B.

1977-01-01

The principle, instrument and procedure of X-ray fluorescence spectrometry are described. It is a rapid, simple and sensitive method for the trace analysis of elements from sodium to uranium in powder, liquid or metal samples. (M.G.B.)

Alpha and beta detection and spectrometry

International Nuclear Information System (INIS)

Saro, S.

1984-01-01

The theory of alpha and beta radioactive decay, the interaction of alpha and beta particles with matter, and their detection and spectrometry are dealt with in seven chapters: 1. Alpha transformation of atomic nuclei; 2. Basic properties of detectors and statistics of detection; 3. Alpha detectors and spectrometers; 4. Applications of alpha detection and spectrometry; 5. Beta transformation of atomic nuclei; 6. Beta particle detectors and spectrometers; 7. Detection of low energy beta particles. Chapter 8 is devoted to sampling and preparation of samples for radiometry. (E.F.)

Atomic electron spectrometry with synchrotron radiation

International Nuclear Information System (INIS)

Sorensen, S.L.

1989-01-01

Techniques of atomic electron spectrometry were applied to atoms in the gaseous and solid states to derive information about fundamental atomic properties. A new method was developed to measure Coster-Kronig yields in metals by photoionization with synchrotron radiation. Photon-energy sensitive Si L-VV Auger satellites were investigated via electron spectrometry. The krypton 1s photoionization spectrum was measured in an experiment which was motivated by the need to understand the krypton 1s satellite spectrum for calibration of an experiment to measure the mass of the electron antineutrino

Quantitative Thin-Layer Chromatography/Mass Spectrometry Analysis of Caffeine Using a Surface Sampling Probe Electrospray Ionization Tandem Mass Spectrometry System

Energy Technology Data Exchange (ETDEWEB)

Ford, Michael J [ORNL; Deibel, Michael A. [Earlham College; Tomkins, Bruce A [ORNL; Van Berkel, Gary J [ORNL

2005-01-01

Quantitative determination of caffeine on reversed-phase C8 thin-layer chromatography plates using a surface sampling electrospray ionization system with tandem mass spectrometry detection is reported. The thin-layer chromatography/electrospray tandem mass spectrometry method employed a deuterium-labeled caffeine internal standard and selected reaction monitoring detection. Up to nine parallel caffeine bands on a single plate were sampled in a single surface scanning experiment requiring 35 min at a surface scan rate of 44 {mu}m/s. A reversed-phase HPLC/UV caffeine assay was developed in parallel to assess the mass spectrometry method performance. Limits of detection for the HPLC/UV and thin-layer chromatography/electrospray tandem mass spectrometry methods determined from the calibration curve statistics were 0.20 ng injected (0.50 {mu}L) and 1.0 ng spotted on the plate, respectively. Spike recoveries with standards and real samples ranged between 97 and 106% for both methods. The caffeine content of three diet soft drinks (Diet Coke, Diet Cherry Coke, Diet Pepsi) and three diet sport drinks (Diet Turbo Tea, Speed Stack Grape, Speed Stack Fruit Punch) was measured. The HPLC/UV and mass spectrometry determinations were in general agreement, and these values were consistent with the quoted values for two of the three diet colas. In the case of Diet Cherry Coke and the diet sports drinks, the determined caffeine amounts using both methods were consistently higher (by 8% or more) than the literature values.

Analytical mass spectrometry

Energy Technology Data Exchange (ETDEWEB)

1990-01-01

This 43rd Annual Summer Symposium on Analytical Chemistry was held July 24--27, 1990 at Oak Ridge, TN and contained sessions on the following topics: Fundamentals of Analytical Mass Spectrometry (MS), MS in the National Laboratories, Lasers and Fourier Transform Methods, Future of MS, New Ionization and LC/MS Methods, and an extra session. (WET)

An analytical solution of Richards' equation providing the physical basis of SCS curve number method and its proportionality relationship

Science.gov (United States)

Hooshyar, Milad; Wang, Dingbao

2016-08-01

The empirical proportionality relationship, which indicates that the ratio of cumulative surface runoff and infiltration to their corresponding potentials are equal, is the basis of the extensively used Soil Conservation Service Curve Number (SCS-CN) method. The objective of this paper is to provide the physical basis of the SCS-CN method and its proportionality hypothesis from the infiltration excess runoff generation perspective. To achieve this purpose, an analytical solution of Richards' equation is derived for ponded infiltration in shallow water table environment under the following boundary conditions: (1) the soil is saturated at the land surface; and (2) there is a no-flux boundary which moves downward. The solution is established based on the assumptions of negligible gravitational effect, constant soil water diffusivity, and hydrostatic soil moisture profile between the no-flux boundary and water table. Based on the derived analytical solution, the proportionality hypothesis is a reasonable approximation for rainfall partitioning at the early stage of ponded infiltration in areas with a shallow water table for coarse textured soils.

Entre el dios de Paley y el dios de Bonnet - El parco evolucionismo teísta de Richard Owen

Directory of Open Access Journals (Sweden)

Gustavo Caponi

2013-04-01

Full Text Available http://dx.doi.org/10.5007/1808-1711.2013v17n1p71 En primer lugar, en este artículo se examina el carácter de las putativas referencias a la evolución de las especies que encontramos en las obras que Richard Owen publicó antes de 1858; y luego se analizan las escazas y vagas conjeturas evolucionistas que Owen sin duda formuló con posterioridad a la presentación pública de la Teoría de la Selección Natural.  En lo que respecta a lo primero, el objetivo es subrayar la ambigüedad de esas referencias de Owen; y en lo que respecta a lo segundo lo que interesa es mostrar que, a la hora de explicitar sus tesis evolucionistas, Owen no fue más allá de un pío evolucionismo teísta que, sin postular ningún mecanismo del cambio evolutivo, permanecía fiel a la Teología del diseño preconizada por Paley.

High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) for Mass Spectrometry-Based Proteomics

Science.gov (United States)

Swearingen, Kristian E.; Moritz, Robert L.

2013-01-01

SUMMARY High field asymmetric waveform ion mobility spectrometry (FAIMS) is an atmospheric pressure ion mobility technique that separates gas-phase ions by their behavior in strong and weak electric fields. FAIMS is easily interfaced with electrospray ionization and has been implemented as an additional separation mode between liquid chromatography (LC) and mass spectrometry (MS) in proteomic studies. FAIMS separation is orthogonal to both LC and MS and is used as a means of on-line fractionation to improve detection of peptides in complex samples. FAIMS improves dynamic range and concomitantly the detection limits of ions by filtering out chemical noise. FAIMS can also be used to remove interfering ion species and to select peptide charge states optimal for identification by tandem MS. Here, we review recent developments in LC-FAIMS-MS and its application to MS-based proteomics. PMID:23194268

Mass spectrometry: a revolution in clinical microbiology?

Science.gov (United States)

Lavigne, Jean-Philippe; Espinal, Paula; Dunyach-Remy, Catherine; Messad, Nourredine; Pantel, Alix; Sotto, Albert

2013-02-01

Recently, different bacteriological laboratory interventions that decrease reporting time have been developed. These promising new broad-based techniques have merit, based on their ability to identify rapidly many bacteria, organisms difficult to grow or newly emerging strains, as well as their capacity to track disease transmission. The benefit of rapid reporting of identification and/or resistance of bacteria can greatly impact patient outcomes, with an improvement in the use of antibiotics, in the reduction of the emergence of multidrug resistant bacteria and in mortality rates. Different techniques revolve around mass spectrometry (MS) technology: matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), PCR combined with electrospray ionization-mass spectrometry (PCR/ESIMS), iPLEX MassArray system and other new evolutions combining different techniques. This report emphasizes the (r)evolution of these technologies in clinical microbiology.

Comparison of gas chromatography/isotope ratio mass spectrometry and liquid chromatography/isotope ratio mass spectrometry for carbon stable-isotope analysis of carbohydrates

NARCIS (Netherlands)

Moerdijk-Poortvliet, Tanja C. W.; Schierbeek, Henk; Houtekamer, Marco; van Engeland, Tom; Derrien, Delphine; Stal, Lucas J.; Boschker, Henricus T. S.

2015-01-01

We compared gas chromatography/isotope ratio mass spectrometry (GC/IRMS) and liquid chromatography/isotope ratio mass spectrometry (LC/IRMS) for the measurement of δ(13)C values in carbohydrates. Contrary to GC/IRMS, no derivatisation is needed for LC/IRMS analysis of carbohydrates. Hence, although

Comparison of gas chromatography/isotope ratio mass spectrometry and liquid chromatography/isotope ratio mass spectrometry for carbon stable-isotope analysis of carbohydrates

NARCIS (Netherlands)

Moerdijk-Poortvliet, T.C.W.; Schierbeek, H.; Houtekamer, M.; van Engeland, T.; Derrien, D.; Stal, L.J.; Boschker, H.T.S.

2015-01-01

We compared gas chromatography/isotope ratio mass spectrometry (GC/IRMS) and liquid chromatography/isotope ratio mass spectrometry (LC/IRMS) for the measurement of d13C values in carbohydrates. Contrary to GC/IRMS, no derivatisation is needed for LC/IRMS analysis of carbohydrates. Hence, although

Comparison of gas chromatography/isotope ratio mass spectrometry and liquid chromatography/isotope ratio mass spectrometry for carbon stable-isotope analysis of carbohydrates

NARCIS (Netherlands)

Moerdijk-Poortvliet, T.C.W.; Schierbeek, H.; Houtekamer, M.; van Engeland, T.; Derrien, D.; Stal, L.J.; Boschker, H.T.S.

2015-01-01

Rationale: We compared gas chromatography/isotope ratio mass spectrometry (GC/IRMS) and liquid chromatography/isotope ratio mass spectrometry (LC/IRMS) for the measurement of δ13C values in carbohydrates. Contrary to GC/IRMS, no derivatisation is needed for LC/IRMS analysis of carbohydrates. Hence,

Cs+ ion source for secondary ion mass spectrometry

International Nuclear Information System (INIS)

Bentz, B.L.; Weiss, H.; Liebl, H.

1981-12-01

Various types of cesium ionization sources currently used in secondary ion mass spectrometry are briefly reviewed, followed by a description of the design and performance of a novel, thermal surface ionization Cs + source developed in this laboratory. The source was evaluated for secondary ion mass spectrometry applications using the COALA ion microprobe mass analyzer. (orig.)

[Advances in mass spectrometry-based approaches for neuropeptide analysis].

Science.gov (United States)

Ji, Qianyue; Ma, Min; Peng, Xin; Jia, Chenxi; Ji, Qianyue

2017-07-25

Neuropeptides are an important class of endogenous bioactive substances involved in the function of the nervous system, and connect the brain and other neural and peripheral organs. Mass spectrometry-based neuropeptidomics are designed to study neuropeptides in a large-scale manner and obtain important molecular information to further understand the mechanism of nervous system regulation and the pathogenesis of neurological diseases. This review summarizes the basic strategies for the study of neuropeptides using mass spectrometry, including sample preparation and processing, qualitative and quantitative methods, and mass spectrometry imagining.

Mass Spectrometry Imaging, an Emerging Technology in Neuropsychopharmacology

Science.gov (United States)

Shariatgorji, Mohammadreza; Svenningsson, Per; Andrén, Per E

2014-01-01

Mass spectrometry imaging is a powerful tool for directly determining the distribution of proteins, peptides, lipids, neurotransmitters, metabolites and drugs in neural tissue sections in situ. Molecule-specific imaging can be achieved using various ionization techniques that are suited to different applications but which all yield data with high mass accuracies and spatial resolutions. The ability to simultaneously obtain images showing the distributions of chemical species ranging from metal ions to macromolecules makes it possible to explore the chemical organization of a sample and to correlate the results obtained with specific anatomical features. The imaging of biomolecules has provided new insights into multiple neurological diseases, including Parkinson's and Alzheimer's disease. Mass spectrometry imaging can also be used in conjunction with other imaging techniques in order to identify correlations between changes in the distribution of important chemical species and other changes in the properties of the tissue. Here we review the applications of mass spectrometry imaging in neuroscience research and discuss its potential. The results presented demonstrate that mass spectrometry imaging is a useful experimental method with diverse applications in neuroscience. PMID:23966069

Mass spectrometry imaging, an emerging technology in neuropsychopharmacology.

Science.gov (United States)

Shariatgorji, Mohammadreza; Svenningsson, Per; Andrén, Per E

2014-01-01

Mass spectrometry imaging is a powerful tool for directly determining the distribution of proteins, peptides, lipids, neurotransmitters, metabolites and drugs in neural tissue sections in situ. Molecule-specific imaging can be achieved using various ionization techniques that are suited to different applications but which all yield data with high mass accuracies and spatial resolutions. The ability to simultaneously obtain images showing the distributions of chemical species ranging from metal ions to macromolecules makes it possible to explore the chemical organization of a sample and to correlate the results obtained with specific anatomical features. The imaging of biomolecules has provided new insights into multiple neurological diseases, including Parkinson's and Alzheimer's disease. Mass spectrometry imaging can also be used in conjunction with other imaging techniques in order to identify correlations between changes in the distribution of important chemical species and other changes in the properties of the tissue. Here we review the applications of mass spectrometry imaging in neuroscience research and discuss its potential. The results presented demonstrate that mass spectrometry imaging is a useful experimental method with diverse applications in neuroscience.

Fourier Transform Mass Spectrometry.

Science.gov (United States)

Gross, Michael L.; Rempel, Don L.

1984-01-01

Discusses the nature of Fourier transform mass spectrometry and its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. Examines its operation, capabilities and limitations, applications (ion storage, ion manipulation, ion chemistry), and future applications and developments. (JN)

Radio-frequency glow discharge spectrometry: A critical review

International Nuclear Information System (INIS)

Winchester, Michael R.; Payling, Richard

2004-01-01

This paper presents a critical review of analytical radio frequency glow discharge spectrometry (rf-GDS). The historical foundations of rf-GDS are described, and current knowledge of the fundamental physics of analytical rf glow discharges is discussed. Additionally, instrumentation, methodologies, and applications of rf glow discharge optical emission spectrometry (rf-GDOES) and mass spectrometry (rf-GDMS) are reviewed. Although other rf-GDS techniques have appeared [e.g. rf glow discharge atomic absorption spectrophotometry (rf-GDAAS)], the emphasis is placed upon rf-GDOES and rf-GDMS, because they have received by far the most interest from analytical chemical metrologists. This review also provides explanations of some developments that are needed for further progress in the field of analytical rf-GDS

First record of the Asian diaptomid Neodiaptomus schmackeri (Poppe & Richard, 1892 (Crustacea: Copepoda: Calanoida in Europe

Directory of Open Access Journals (Sweden)

Giuseppe Alfonso

2014-06-01

Full Text Available Albania, as well as a great part of the Balkan area in general, still suffers a lack of environmental studies especially in limnological research. The Dumre plateau, in Central Albania, is characterized by an extraordinary high number of karst lakes in a small geographic area. Despite their environmental peculiarity, very few biological data are to date available for these lakes, none on the zooplankton. For this reason, 15 water bodies located in the central area of the plateau were selected for a preliminary limnological survey carried out in the years 2008-2011. Neodiaptomus schmackeri (Poppe & Richard, 1892, a diaptomid calanoid copepod characterized by a South-Eastern Palearctic - Oriental distribution, and the most widely spread Neodiaptomus species in Asia, was found in 8 lakes of the Dumre area. This finding represents the first record of the species, and of the entire genus Neodiaptomus, for Europe. Several environmental variables were measured to characterize the lakes, and the co-occurring planktonic crustaceans were also identified. Taxonomical drawings and descriptions of the main morphological features of both sexes are herein provided in order to compare the Albanian populations of N. schmackeri with those of the native distribution area of the species. The possible causes which determined the occurrence of this non-indigenous species in several Dumre lakes are discussed.

Identification of Fatty Acids, Phospholipids, and Their Oxidation Products Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Electrospray Ionization Mass Spectrometry

Science.gov (United States)

Harmon, Christopher W.; Mang, Stephen A.; Greaves, John; Finlayson-Pitts, Barbara J.

2010-01-01

Electrospray ionization mass spectrometry (ESI-MS) and matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) have found increasing application in the analysis of biological samples. Using these techniques to solve problems in analytical chemistry should be an essential component of the training of undergraduate chemists. We…

Quantification of steroid conjugates using fast atom bombardment mass spectrometry

International Nuclear Information System (INIS)

Gaskell, S.J.

1990-01-01

Fast atom bombardment/mass spectrometry or liquid secondary ion mass spectrometry provides the capability for direct analysis of steroid conjugates (sulfates, glucuronides) without prior hydrolysis or derivatization. During the analysis of biologic extracts, limitations on the sensitivity of detection arise from the presence of co-extracted material which may suppress or obscure the analyte signal. A procedure is described for the quantitative determination of dehydroepiandrosterone sulfate in serum which achieved selective isolation of the analyte using immunoadsorption extraction and highly specific detection using tandem mass spectrometry. A stable isotope-labeled analog [( 2H2]dehydroepiandrosterone sulfate) was used as internal standard. Fast atom bombardment of dehydroepiandrosterone sulfate yielded abundant [M-H]- ions that fragmented following collisional activation to give HSO4-; m/z 97. During fast atom bombardment/tandem mass spectrometry of serum extracts, a scan of precursor ions fragmenting to give m/z 97 detected dehydroepiandrosterone sulfate and the [2H2]-labeled analog with a selectivity markedly superior to that observed using conventional mass spectrometry detection. Satisfactory agreement was observed between quantitative data obtained in this way and data obtained by gas chromatography/mass spectrometry of the heptafluorobutyrates of dehydroepiandrosterone sulfate and [2H2]dehydroepiandrosterone sulfate obtained by direct derivatization. 21 refs

High-efficiency thermal ionization sources for mass spectrometry

International Nuclear Information System (INIS)

Olivares, Jose A.

1996-01-01

A version of the thermal ionization cavity (TIC) source developed specifically for use in mass spectrometry is presented. The performance of this ion source has been characterized extensively both with the use of an isotope separator and a quadrupole mass spectrometer. A detailed description of the TIC source for mass spectrometry is given along with the performance characteristics observed

A low-cost vaporization-atomization system for atomic absorption spectrometry

International Nuclear Information System (INIS)

Bruhn F, C.G.; Ambiado V, F.; Woerner V, R.

1990-01-01

A low-cost vaporization-atomization system for atomic absorption spectrometry is developed as an alternative to the use of a graphite furnace in electrothermal atomic absorption spectrometry. (Author)

Plutonium determination in urine by techniques of mass spectrometry

International Nuclear Information System (INIS)

Hernandez M, H.; Yllera de Ll, A.

2013-10-01

The objective of this study was to develop an analytic method for quantification and plutonium reappraisal in plane tables of alpha spectrometry be means of the mass spectrometry technique of high resolution with plasma source inductively coupled and desolvator Aridus (Aridus-Hr-Icp-Ms) and mass spectrometry with accelerator (AMS). The obtained results were, the recovery percentage of Pu in the plane table was of ∼ 90% and activity minimum detectable obtained with Aridus-Hr-Icp-Ms and AMS was of ∼ 3 and ∼ 0.4 f g of 239 Pu, respectively. Conclusion, the results demonstrate the aptitude of the Aridus-Hr-Icp-Ms and AMS techniques in the Pu reappraisal in plane tables with bigger speed and precision, improving the values notably of the activity minimum detectable that can be obtained with the alpha spectrometry (∼ 50 f g of 239 Pu). (author)

Use of the helium-3 proportional counter for neutron spectrometry; Utilisation du compteur proportionnel a helium 3 pour la spectrometrie des neutrons

Energy Technology Data Exchange (ETDEWEB)

Vialettes, H; Le Thanh, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-07-01

Up to now, two methods have been mainly used for neutron spectrometry near nuclear installations: - photographic emulsion spectrometry - the so-called, 'multisphere' technique spectrometry. The first method, which is fairly difficult to apply, has a threshold energy of about 500 keV; this is a big disadvantage for an apparatus which has to be used for spectrometry around nuclear installations where the neutron radiation is very much degraded energetically. The second method does not suffer from this disadvantage but the results which it yields are only approximate. In order to extend the energy range of the neutron spectra studied with sufficient accuracy the use of a helium-3 proportional counter has been considered. This report presents the principles of operation of the helium-3 spectrometer, and the calculation methods which make it possible to take into account the two main effects tending to deform the spectra obtained: - energy absorption by the walls of the counter, - energy loss of the incident neutrons due to elastic collisions with helium-3 nuclei. As an example of the application, the shape of the neutron spectrum emitted by a polonium-lithium source is given; the results obtained are in excellent agreement with theoretical predictions. (authors) [French] Jusqu'ici deux methodes ont ete utilisees principalement pour la spectrometrie des neutrons autour des installations nucleaires: - la spectrometrie par emulsions photographiques - la spectrometrie par la technique dite des multispheres. La premiere methode, d'un emploi assez delicat presente un seuil en energie d'environ 500 keV qui est un obstacle serieux a la spectrometrie autour des installations nucleaires ou le rayonnement neutronique est tres degrade en energie. La deuxieme methode ne presente pas cet inconvenient mais les resultats qu'elle permet d'obtenir ne sont qu'approches. Pour etendre la gamme d'energie des spectres de neutrons etudies avec une precision suffisante, l'utilisation du

An Enlightenment proposal for music therapy: Richard Brocklesby on music, spirit, and the passions.

Science.gov (United States)

Gouk, Penelope

2015-01-01

In 1749, the London physician Richard Brocklesby (1722-1797) published his Reflections on Antient [sic] and Modern Musick, an essay that not only sought to compare these practices in terms of their effects, but also to gather evidence supporting the use of music in treating mania and other mental diseases. As might be expected, Brocklesby's discussion of music therapy has already received attention by authors looking back to the origins of this practice, not least because he offers an account of a successful musical cure that took place in his own time (Rorke, 2001). My chapter, however, seeks to broaden the discussion of the Reflections, in order to show how Brocklesby's projected musical cures fit into his larger worldview, one that was influenced as much by Plato and other ancient philosophers as it was by modern thinkers such as Isaac Newton and his followers. Brocklesby's argument was essentially that music acted as a link between the mind and body and therefore could restore their intrinsic harmony, a connection that was mediated by the animal spirits, which also served as the vehicle of the passions. The movements and proportions of music could arouse or quell the passions by their effect on these (imaginary) spirits, which flowed through the nerves and brain and acted as the agent for the mind or soul. I show how his account of music in antiquity led him to reflect on the way that music was perceived and responded to in his own time, both as a stimulus to mental and bodily action, and as a source of esthetic pleasure through the cultivation of musical taste. © 2015 Elsevier B.V. All rights reserved.

Miniaturization and Mass Spectrometry

NARCIS (Netherlands)

le Gac, S.; le Gac, Severine; van den Berg, Albert; van den Berg, A.; Unknown, [Unknown

2009-01-01

With this book we want to illustrate how two quickly growing fields of instrumentation and technology, both applied to life sciences, mass spectrometry and microfluidics (or microfabrication) naturally came to meet at the end of the last century and how this marriage impacts on several types of

Exact and grid-free solutions to the Lighthill-Whitham-Richards traffic flow model with bounded acceleration for a class of fundamental diagrams

KAUST Repository

Qiu, Shanwen

2013-09-01

In this article, we propose a new exact and grid-free numerical scheme for computing solutions associated with an hybrid traffic flow model based on the Lighthill-Whitham-Richards (LWR) partial differential equation, for a class of fundamental diagrams. In this hybrid flow model, the vehicles satisfy the LWR equation whenever possible, and have a constant acceleration otherwise. We first propose a mathematical definition of the solution as a minimization problem. We use this formulation to build a grid-free solution method for this model based on the minimization of component function. We then derive these component functions analytically for triangular fundamental diagrams, which are commonly used to model traffic flow. We also show that the proposed computational method can handle fixed or moving bottlenecks. A toolbox implementation of the resulting algorithm is briefly discussed, and posted at https://dl.dropbox.com/u/1318701/Toolbox.zip. © 2013 Elsevier Ltd.

Recent applications of gas chromatography with high-resolution mass spectrometry.

Science.gov (United States)

Špánik, Ivan; Machyňáková, Andrea

2018-01-01

Gas chromatography coupled to high-resolution mass spectrometry is a powerful analytical method that combines excellent separation power of gas chromatography with improved identification based on an accurate mass measurement. These features designate gas chromatography with high-resolution mass spectrometry as the first choice for identification and structure elucidation of unknown volatile and semi-volatile organic compounds. Gas chromatography with high-resolution mass spectrometry quantitative analyses was previously focused on the determination of dioxins and related compounds using magnetic sector type analyzers, a standing requirement of many international standards. The introduction of a quadrupole high-resolution time-of-flight mass analyzer broadened interest in this method and novel applications were developed, especially for multi-target screening purposes. This review is focused on the development and the most interesting applications of gas chromatography coupled to high-resolution mass spectrometry towards analysis of environmental matrices, biological fluids, and food safety since 2010. The main attention is paid to various approaches and applications of gas chromatography coupled to high-resolution mass spectrometry for non-target screening to identify contaminants and to characterize the chemical composition of environmental, food, and biological samples. The most interesting quantitative applications, where a significant contribution of gas chromatography with high-resolution mass spectrometry over the currently used methods is expected, will be discussed as well. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

OBT measurement of vegetation by mass spectrometry and radiometry

International Nuclear Information System (INIS)

Tamari, T.; Kakiuchi, H.; Momoshima, N.; Sugihara, S.; Baglan, N.; Uda, T.

2011-01-01

We carried out OBT (organically bound tritium) measurement by two different methods those are radiometry and mass spectrometry and compared the applicability of these methods for environmental tritium analysis. The dried grass sample was used for the experiments. To eliminate the exchangeable OBT, the sample was washed with tritium free water before analysis. Three times washing reduced the tritium activity in the labile sites below the detectable level. In radiometry the sample was combusted to convert the OBT as well as other hydrogen isotopes to. water and tritium activity in the water was measured by liquid scintillation counting (LSC). In mass spectrometry, the sample was kept in a glass container and 3 He produced by tritium decay was measured by mass spectrometry. The results were in good agreement suggesting applicability of these methods for environmental tritium analysis. The mass spectrometry is more suitable for environmental tritium research because of a lower detection limit than that of the LSC. (authors)

Sequencing Cyclic Peptides by Multistage Mass Spectrometry

Science.gov (United States)

Mohimani, Hosein; Yang, Yu-Liang; Liu, Wei-Ting; Hsieh, Pei-Wen; Dorrestein, Pieter C.; Pevzner, Pavel A.

2012-01-01

Some of the most effective antibiotics (e.g., Vancomycin and Daptomycin) are cyclic peptides produced by non-ribosomal biosynthetic pathways. While hundreds of biomedically important cyclic peptides have been sequenced, the computational techniques for sequencing cyclic peptides are still in their infancy. Previous methods for sequencing peptide antibiotics and other cyclic peptides are based on Nuclear Magnetic Resonance spectroscopy, and require large amount (miligrams) of purified materials that, for most compounds, are not possible to obtain. Recently, development of mass spectrometry based methods has provided some hope for accurate sequencing of cyclic peptides using picograms of materials. In this paper we develop a method for sequencing of cyclic peptides by multistage mass spectrometry, and show its advantages over single stage mass spectrometry. The method is tested on known and new cyclic peptides from Bacillus brevis, Dianthus superbus and Streptomyces griseus, as well as a new family of cyclic peptides produced by marine bacteria. PMID:21751357

Atmospheric pressure chemical ionization studies of non-polar isomeric hydrocarbons using ion mobility spectrometry and mass spectrometry with different ionization techniques

Science.gov (United States)

Borsdorf, H.; Nazarov, E. G.; Eiceman, G. A.

2002-01-01

The ionization pathways were determined for sets of isomeric non-polar hydrocarbons (structural isomers, cis/trans isomers) using ion mobility spectrometry and mass spectrometry with different techniques of atmospheric pressure chemical ionization to assess the influence of structural features on ion formation. Depending on the structural features, different ions were observed using mass spectrometry. Unsaturated hydrocarbons formed mostly [M - 1]+ and [(M - 1)2H]+ ions while mainly [M - 3]+ and [(M - 3)H2O]+ ions were found for saturated cis/trans isomers using photoionization and 63Ni ionization. These ionization methods and corona discharge ionization were used for ion mobility measurements of these compounds. Different ions were detected for compounds with different structural features. 63Ni ionization and photoionization provide comparable ions for every set of isomers. The product ions formed can be clearly attributed to the structures identified. However, differences in relative abundance of product ions were found. Although corona discharge ionization permits the most sensitive detection of non-polar hydrocarbons, the spectra detected are complex and differ from those obtained with 63Ni ionization and photoionization. c. 2002 American Society for Mass Spectrometry.

Imaging Mass Spectrometry in Neuroscience

Science.gov (United States)

2013-01-01

Imaging mass spectrometry is an emerging technique of great potential for investigating the chemical architecture in biological matrices. Although the potential for studying neurobiological systems is evident, the relevance of the technique for application in neuroscience is still in its infancy. In the present Review, a principal overview of the different approaches, including matrix assisted laser desorption ionization and secondary ion mass spectrometry, is provided with particular focus on their strengths and limitations for studying different neurochemical species in situ and in vitro. The potential of the various approaches is discussed based on both fundamental and biomedical neuroscience research. This Review aims to serve as a general guide to familiarize the neuroscience community and other biomedical researchers with the technique, highlighting its great potential and suitability for comprehensive and specific chemical imaging. PMID:23530951

Neutron spectrometry and dosimetry with ANNs

International Nuclear Information System (INIS)

Vega C, H. R.; Hernandez D, V. M.; Gallego, E.; Lorente, A.

2009-10-01

Artificial neural networks technology has been applied to unfold the neutron spectra and to calculate the effective dose, the ambient equivalent dose, and the personal dose equivalent for 252 Cf and 241 AmBe neutron sources. A Bonner sphere spectrometry with a 6 LiI(Eu) scintillator was utilized to measure the count rates of the spheres that were utilized as input in two artificial neural networks, one for spectrometry and another for dosimetry. Spectra and the ambient dose equivalent were also obtained with BUNKIUT code and the UTA4 response matrix. With both procedures spectra and ambient dose equivalent agrees in less than 10%. (author)

An automatic sample changer for gamma spectrometry

International Nuclear Information System (INIS)

Andrews, D.J.

1984-01-01

An automatic sample changer for gamma spectrometry is described which is designed for large-volume, low radioactivity environmental samples of various sizes up to maximum dimensions 100 mm diameter x 60 mm high. The sample changer is suitable for use with most existing gamma spectrometry systems which utilize GeLi or NaI detectors in vertical mode, in conjunction with a pulse height analyzer having auto-cycle and suitable data output facilities; it is linked to a Nuclear Data ND 6620 computer-based analysis system. (U.K.)

Training course on inductively coupled plasma spectrometry - Note

Digital Repository Service at National Institute of Oceanography (India)

Valsangkar, A.B.

TRAINING COURSE ON INDUCTIVELY COUPLED PLASMA SPECTROMETRY In the present day geological, chemical, environmental and archaeological research activities, the Inductively Coupled Plasma (ICP) Spectrometry is established as a cost-effective multi... the knowledge and advances in the analytical tools and methodologies for the benefit of the research scholars as well as professionals. National Institute of Oceanography, A.B. VALSANGKAR Dona Paula - 403 004 slip tectonics playing a major role...

Proceedings of the twelfth ISMAS triennial international conference on mass spectrometry

International Nuclear Information System (INIS)

Aggarwal, S.K.; Jaison, P.G.; Telmore, V.M.

2013-03-01

These Workshops are aimed at introducing the subject of Mass Spectrometry to novices, updating the Mass Spectrometrists with the latest developments in the field, exposing the participants to innumerable applications of Mass Spectrometry and providing a common forum for discussing the day-to-day problems when working with a Mass Spectrometer. The programme of these Workshops consists of Tutorials, Panel Discussions, Research Scholars' Presentations, Poster Presentations and Invited Lectures. The lectures include fundamentals of Mass Spectrometry, qualitative and quantitative aspects and data interpretation, maintenance of Mass Spectrometers, selection of a mass spectrometer, applications in various branches of science as well as recent advances in Mass Spectrometry. Papers relevant to INIS are indexed separately

Analysis of [U-13C6]glucose in human plasma using liquid chromatography/isotope ratio mass spectrometry compared with two other mass spectrometry techniques

NARCIS (Netherlands)

Schierbeek, H.; Moerdijk-Poortvliet, T.C.W.; van den Akker, C.H.P.; te Braake, F.W.J.; Boschker, H.T.S.; van Goudoever, J.B.

2009-01-01

The use of stable isotope labelled glucose provides insight into glucose metabolism. The 13C-isotopic enrichment of glucose is usually measured by gas chromatography/mass spectrometry (GC/MS) or gas chromatography/combustion/isotope ratio mass spectrometry (GC/C/IRMS). However, in both techniques

Zero voltage mass spectrometry probes and systems

Science.gov (United States)

Cooks, Robert Graham; Wleklinski, Michael Stanley; Bag, Soumabha; Li, Yafeng

2017-10-10

The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.

Analog to digital conversion for nuclear spectrometry

International Nuclear Information System (INIS)

Carvalho, P.V.R. de.

1982-04-01

A study of the analog to digital conversion techniques for nuclear spectrometry is presented and the main design philosophies of nuclear ADC's are compared. Among them, the most suitable for the current Brazilian conditions, concerning the specifications and components avaiability is the one that employs a statistical correction of successive approximation converters. This technique is described in full detail. A prototype has been developed an tested for the practical demonstration of the theoretical conclusions. These tests was carried on nuclear spectrometry data aquisition system whose implementation is also described. (Author) [pt

Development of stereotactic mass spectrometry for brain tumor surgery.

Science.gov (United States)

Agar, Nathalie Y R; Golby, Alexandra J; Ligon, Keith L; Norton, Isaiah; Mohan, Vandana; Wiseman, Justin M; Tannenbaum, Allen; Jolesz, Ferenc A

2011-02-01

Surgery remains the first and most important treatment modality for the majority of solid tumors. Across a range of brain tumor types and grades, postoperative residual tumor has a great impact on prognosis. The principal challenge and objective of neurosurgical intervention is therefore to maximize tumor resection while minimizing the potential for neurological deficit by preserving critical tissue. To introduce the integration of desorption electrospray ionization mass spectrometry into surgery for in vivo molecular tissue characterization and intraoperative definition of tumor boundaries without systemic injection of contrast agents. Using a frameless stereotactic sampling approach and by integrating a 3-dimensional navigation system with an ultrasonic surgical probe, we obtained image-registered surgical specimens. The samples were analyzed with ambient desorption/ionization mass spectrometry and validated against standard histopathology. This new approach will enable neurosurgeons to detect tumor infiltration of the normal brain intraoperatively with mass spectrometry and to obtain spatially resolved molecular tissue characterization without any exogenous agent and with high sensitivity and specificity. Proof of concept is presented in using mass spectrometry intraoperatively for real-time measurement of molecular structure and using that tissue characterization method to detect tumor boundaries. Multiple sampling sites within the tumor mass were defined for a patient with a recurrent left frontal oligodendroglioma, World Health Organization grade II with chromosome 1p/19q codeletion, and mass spectrometry data indicated a correlation between lipid constitution and tumor cell prevalence. The mass spectrometry measurements reflect a complex molecular structure and are integrated with frameless stereotaxy and imaging, providing 3-dimensional molecular imaging without systemic injection of any agents, which can be implemented for surgical margins delineation of

X-ray spectrometry for preventive conservation of cultural heritage

Indian Academy of Sciences (India)

Analytical chemistry does play a key role in the chemical characterization of the environment and it appears that X-ray spectrometry, in its many forms, is one of the most relevant analytical techniques in preventive conservation, as it is in cultural heritage research in general. X-ray spectrometry has indeed been the method ...

Instrumentation for mass spectrometry: 1997

Energy Technology Data Exchange (ETDEWEB)

McLuckey, S.A.

1997-08-01

All mass spectrometry experiments involve the manipulation of material, an interface with the mass spectrometer, ionization, ion manipulation/analysis, detection and data collection/reduction. Each of these elements involve instrumentation. The wide range of species now amenable to mass spectrometry and the diverse areas of physical science in which it plays a role have led to a seemingly unlimited array of instrumental combinations. However, only a limited number of mass analyzers, and their combinations, dominate. The dominant analyzers include time-of-flight, Fourier transform ion cyclotron resonance, the Paul trap, the mass filter, and the sector mass spectrometer. Why there are so few (or so many, depending upon one`s point of view) can be understood upon consideration of a set of mass analyzer figures of merit. These include mass resolution, mass accuracy, mass range, dynamic range, abundance sensitivity, precision, efficiency, speed, MS{sup n} capability, compatibility with the ionizer, cost, and size. The most appropriate form of mass spectrometry is determined by the priorities of the particular measurement placed on the various mass analyzer characteristics and the relative strengths of the analyzers in meeting the requirements. Each of the analyzer types has a unique set of figures of merit that makes it optimally suited for particular applications. This paper discusses these figures of merit, provides data illustrating recent developments for each analyzer type, and gives the figures of merit of each type of analyzer as they stand in 1997. 101 refs., 24 figs.

Accelerator mass spectrometry-current status in techniques and applications

International Nuclear Information System (INIS)

Imamura, Mineo; Nagai, Hisao; Kobayashi, Koichi.

1991-01-01

Accelerator mass spectrometry (AMS) is the mass spectrometry by incorporating an accelerator. After samples are ionized, they are accelerated to a certain energy, and mass, energy, nuclear charge (atomic number) are distinguished, and ion counting is made one by one with a heavy ion detector. For the measurement of long half-life radioisotopes, mass spectrometry has been used because of the high sensitivity, but in low energy mass spectrometry, there are the difficulties due to the mixing of the molecular ions having nearly same mass and the existence of isobars. One of the methods solving these difficulties is an accelerator which enables background-free measurement. The progress of AMS is briefly described, and at present, it is carried out in about 30 facilities in the world. In AMS, the analysis is carried out in the order of the ionization of samples, the acceleration of beam, the electron stripping with a thin film, the sorting of the momentum and energy of beam and the identification of particles. The efficiency, sensitivity and accuracy of detection and the application are reported. (K.I.)

Mass Spectrometry Imaging under Ambient Conditions

Science.gov (United States)

Wu, Chunping; Dill, Allison L.; Eberlin, Livia S.; Cooks, R. Graham; Ifa, Demian R.

2012-01-01

Mass spectrometry imaging (MSI) has emerged as an important tool in the last decade and it is beginning to show potential to provide new information in many fields owing to its unique ability to acquire molecularly specific images and to provide multiplexed information, without the need for labeling or staining. In MSI, the chemical identity of molecules present on a surface is investigated as a function of spatial distribution. In addition to now standard methods involving MSI in vacuum, recently developed ambient ionization techniques allow MSI to be performed under atmospheric pressure on untreated samples outside the mass spectrometer. Here we review recent developments and applications of MSI emphasizing the ambient ionization techniques of desorption electrospray ionization (DESI), laser ablation electrospray ionization (LAESI), probe electrospray ionization (PESI), desorption atmospheric pressure photoionization (DAPPI), femtosecond laser desorption ionization (fs-LDI), laser electrospray mass spectrometry (LEMS), infrared laser ablation metastable-induced chemical ionization (IR-LAMICI), liquid microjunction surface sampling probe mass spectrometry (LMJ-SSP MS), nanospray desorption electrospray ionization (nano-DESI), and plasma sources such as the low temperature plasma (LTP) probe and laser ablation coupled to flowing atmospheric-pressure afterglow (LA-FAPA). Included are discussions of some of the features of ambient MSI including the ability to implement chemical reactions with the goal of providing high abundance ions characteristic of specific compounds of interest and the use of tandem mass spectrometry to either map the distribution of targeted molecules with high specificity or to provide additional MS information in the structural identification of compounds. We also describe the role of bioinformatics in acquiring and interpreting the chemical and spatial information obtained through MSI, especially in biological applications for tissue

Practical aspects of trapped ion mass spectrometry, 5 applications of ion trapping devices

CERN Document Server

March, Raymond E

2009-01-01

Examines ion/neutral and ion/ion reactions, ion spectroscopy, and the structural characterization of proteins and peptides using quadropole ion trap mass spectrometry, Fourier transform - ion cyclotron resonance (FT-ICR) mass spectrometry, and traveling wave ion mobility mass spectrometry.

The rudiments of an Internet-based health plan for consumers: an interview with John Danaher, MD, MBA. Interview by Richard L. Reece.

Science.gov (United States)

Danaher, J

2000-01-01

Richard L. Reece, MD, interviewed John Danaher, MD, MBA, on August 16, 2000, to discuss how his new company is preparing for the perfect storm--the looming convergence of demanding consumers, defined contributions, and Internet-based health plans. He describes how his firm is putting financial and clinical tools in the hands of consumers and physicians, so consumers can be more enlightened in their health care choices. Danaher says, "We're not about buying goods and services online. We are transforming the way consumers buy health care and seek insurance. We're trying to be a 401 k where people get on, knowing their risk profile and return horizons. We aim to motivate consumers to be proactive in making health care choices. How do we make consumers responsible and motivated enough to take control of managing their health care costs? How well we articulate this call to consumer action will be the key to our success."

Identification of chemical components in Baidianling Capsule based on gas chromatography-mass spectrometry and high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry.

Science.gov (United States)

Wu, Wenying; Chen, Yu; Wang, Binjie; Sun, Xiaoyang; Guo, Ping; Chen, Xiaohui

2017-08-01

Baidianling Capsule, which is made from 16 Chinese herbs, has been widely used for treating vitiligo clinically. In this study, the sensitive and rapid method has been developed for the analysis of chemical components in Baidianling Capsule by gas chromatography-mass spectrometry in combination with retention indices and high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. Firstly, a total of 110 potential volatile compounds obtained from different extraction procedures including alkanes, alkenes, alkynes, ketones, ethers, aldehydes, alcohols, phenols, organic acids, esters, furans, pyrrole, acid amides, heterocycles, and oxides were detected from Baidianling Capsule by gas chromatography-mass spectrometry, of which 75 were identified by mass spectrometry in combination with the retention index. Then, a total of 124 components were tentatively identified by high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. Fifteen constituents from Baidianling Capsule were accurately identified by comparing the retention times with those of reference compounds, others were identified by comparing the retention times and mass spectrometry data, as well as retrieving the reference literature. This study provides a practical strategy for rapidly screening and identifying the multiple constituents of a complex traditional Chinese medicine. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Phylogenetic Analysis Using Protein Mass Spectrometry.

Science.gov (United States)

Ma, Shiyong; Downard, Kevin M; Wong, Jason W H

2017-01-01

Through advances in molecular biology, comparative analysis of DNA sequences is currently the cornerstone in the study of molecular evolution and phylogenetics. Nevertheless, protein mass spectrometry offers some unique opportunities to enable phylogenetic analyses in organisms where DNA may be difficult or costly to obtain. To date, the methods of phylogenetic analysis using protein mass spectrometry can be classified into three categories: (1) de novo protein sequencing followed by classical phylogenetic reconstruction, (2) direct phylogenetic reconstruction using proteolytic peptide mass maps, and (3) mapping of mass spectral data onto classical phylogenetic trees. In this chapter, we provide a brief description of the three methods and the protocol for each method along with relevant tools and algorithms.

Guideline on Isotope Dilution Mass Spectrometry

Energy Technology Data Exchange (ETDEWEB)

Gaffney, Amy [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2017-05-19

Isotope dilution mass spectrometry is used to determine the concentration of an element of interest in a bulk sample. It is a destructive analysis technique that is applicable to a wide range of analytes and bulk sample types. With this method, a known amount of a rare isotope, or ‘spike’, of the element of interest is added to a known amount of sample. The element of interest is chemically purified from the bulk sample, the isotope ratio of the spiked sample is measured by mass spectrometry, and the concentration of the element of interest is calculated from this result. This method is widely used, although a mass spectrometer required for this analysis may be fairly expensive.

Mass Spectrometry of Halopyrazolium Salts

DEFF Research Database (Denmark)

Larsen, Elfinn; Egsgaard, Helge; Pande, U. C.

1983-01-01

Eleven halogen substituted 1-methyl-2-phenylpyrazolium bromides or chlorides were investigated by field desorption, field ionization, and electron impact mass spectrometry. Dealkylation was found to be the predominant thermal decomposition. An exchange between covalent and ionic halogen prior...

Fast neutron spectrometry and dosimetry

International Nuclear Information System (INIS)

Blaize, S.; Ailloud, J.; Mariani, J.; Millot, J.P.

1958-01-01

We have studied fast neutron spectrometry and dosimetry through the recoil protons they produce in hydrogenated samples. In spectrometric, we used nuclear emulsions, in dosimetric, we used polyethylene coated with zinc sulphide and placed before a photomultiplier. (author) [fr

X-ray fluorescence spectrometry

International Nuclear Information System (INIS)

Vries, J.L. de.

1976-01-01

The seventh edition of Philips' Review of Literature on x-ray fluorescence spectrometry starts with a list of conference proceedings on the subject, organised by the Philips organisation at regular intervals in various European countries. It is followed by a list of bulletins. The bibliography is subdivided according to spectra, equipment, applications and absorption analysis

Mass spectrometry in grape and wine chemistry. Part II: The consumer protection.

Science.gov (United States)

Flamini, Riccardo; Panighel, Annarita

2006-01-01

Controls in food industry are fundamental to protect the consumer health. For products of high quality, warranty of origin and identity is required and analytical control is very important to prevent frauds. In this article, the "state of art" of mass spectrometry in enological chemistry as a consumer safety contribute is reported. Gas chromatography-mass spectrometry (GC/MS) and liquid-chromatography-mass spectrometry (LC/MS) methods have been developed to determine pesticides, ethyl carbamate, and compounds from the yeast and bacterial metabolism in wine. The presence of pesticides in wine is mainly linked to the use of dicarboxyimide fungicides on vineyard shortly before the harvest to prevent the Botrytis cinerea attack of grape. Pesticide residues are regulated at maximum residue limits in grape of low ppm levels, but significantly lower levels in wine have to be detected, and mass spectrometry offers effective and sensitive methods. Moreover, mass spectrometry represent an advantageous alternative to the radioactive-source-containing electron capture detector commonly used in GC analysis of pesticides. Analysis of ochratoxin A (OTA) in wine by LC/MS and multiple mass spectrometry (MS/MS) permits to confirm the toxin presence without the use of expensive immunoaffinity columns, or time and solvent consuming sample derivatization procedures. Inductively coupled plasma-mass spectrometry (ICP/MS) is used to control heavy metals contamination in wine, and to verify the wine origin and authenticity. Isotopic ratio-mass spectrometry (IRMS) is applied to reveal wine watering and sugar additions, and to determine the product origin and traceability.

Structural analyses of sucrose laurate regioisomers by mass spectrometry techniques

DEFF Research Database (Denmark)

Lie, Aleksander; Stensballe, Allan; Pedersen, Lars Haastrup

2015-01-01

6- And 6′-O-lauroyl sucrose were isolated and analyzed by matrix-assisted laser desorption/ionisation (MALDI) time-of-flight (TOF) mass spectrometry (MS), Orbitrap high-resolution (HR) MS, and electrospray-ionization (ESI) tandem mass spectrometry (MS/MS). The analyses aimed to explore the physic......6- And 6′-O-lauroyl sucrose were isolated and analyzed by matrix-assisted laser desorption/ionisation (MALDI) time-of-flight (TOF) mass spectrometry (MS), Orbitrap high-resolution (HR) MS, and electrospray-ionization (ESI) tandem mass spectrometry (MS/MS). The analyses aimed to explore.......8, respectively, and Orbitrap HRMS confirmed the mass of [M+Na]+ (m/z 547.2712). ESI-MS/MS on the precursor ion [M+Na]+ resulted in product ion mass spectra showing two high-intensity signals for each sample. 6-O-Lauroyl sucrose produced signals located at m/z 547.27 and m/z 385.21, corresponding to the 6-O...

Matrix digestion of soil and sediment samples for extraction of lead, cadmium and antimony and their direct determination by inductively coupled plasma-mass spectrometry and atomic emission spectrometry

International Nuclear Information System (INIS)

Chattopadhyay, P.; Fisher, A.S.; Henon, D.N.; Hill, S.J.

2004-01-01

An environmentally friendly and simple method has been developed for complete digestion of lead, cadmium and antimony from soil samples using a magnesium nitrate assisted dry ashing procedure. Statistical data for a series of experiments with standard reference materials are presented, and precision values are found to be comparable for inductively coupled plasma-mass spectrometry and for inductively coupled plasma-atomic emission spectrometry. From a single digest solution all analytes are quantified without involving any preconcentration routes. Inter-method comparison of inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES) shows that the probability of the results being different is less than 99 %. (author)

Spectrometry of degraded neutrons with SSNTDs

International Nuclear Information System (INIS)

Gopalani, Deepak; Kumar, S.; Jodha, A.S.; Reddy, A.R.

1993-01-01

Considerable interest has grown during the last decade in the use of solid state nuclear track detectors (SSNTDs) for routine neutron monitoring and dosimetry work. In addition, using these detectors neutron spectrometry has also been undertaken by some investigators. In spectrometry the energy of neutrons was determined either from minor axis of proton tracks observed on the surface of detector or from the use of polyethylene radiators of selected thickness with varying etching time. Using this latter method in the present work fast neutron spectrometry is made. The method involves the measurement of etch induction time, thickness of removed critical layer for constant radiator thickness with varying etching time. Besides a computer programme has been developed for the calculation of neutron sensitivity at different critical removal layers. The degraded neutron spectra of 252 Cf with shield materials of different thickness but of same composition and shield materials of same thickness but of different compositions have been obtained. The study shows that SSNTD films can be used for recording the transmitted neutron spectra from different shield materials. This spectrometric capability added to the technique advantages of SSNTDs such as integrating nature and small size make them important for nuclear engineering applications. (author). 7 refs., 4 figs., 1 tab

Applications of mass spectrometry in the trace element analysis of biological materials

International Nuclear Information System (INIS)

Moens, L.

1997-01-01

The importance of mass spectrometry for the analysis of biological material is illustrated by reviewing the different mass spectrometric methods applied and describing some typical applications published recently. Though atomic absorption spectrometry is used in the majority of analyses of biological material, most mass spectrometric methods have been used to some extent for trace element determination in biomedical research. The relative importance of the different methods is estimated by reviewing recent research papers. It is striking that especially inductively coupled plasma mass spectrometry is increasingly being applied, partly because the method can be used on-line after chromatographic separation, in speciation studies. Mass spectrometric methods prove to offer unique possibilities in stable isotope tracer studies and for this purpose also experimentally demanding methods such as thermal ionization mass spectrometry and accelerator mass spectrometry are frequently used. (orig.)

Beta spectrometry

International Nuclear Information System (INIS)

Dryak, P.; Zderadicka, J.; Plch, J.; Kokta, L.; Novotna, P.

1977-01-01

For the purpose of beta spectrometry, a semiconductor spectrometer with one Si(Li) detector cooled with liquid nitrogen was designed. Geometrical detection efficiency is about 10% 4 sr. The achieved resolution for 624 keV conversion electrons of sup(137m)Ba is 2.6 keV (FWHM). A program was written in the FORTRAN language for the correction of the deformation of the measured spectra by backscattering in the analysis of continuous beta spectra. The method permits the determination of the maximum energy of the beta spectrum with an accuracy of +-5 keV. (author)

An Exact and Grid-free Numerical Scheme for the Hybrid Two Phase Traffic Flow Model Based on the Lighthill-Whitham-Richards Model with Bounded Acceleration

KAUST Repository

Qiu, Shanwen

2012-07-01

In this article, we propose a new grid-free and exact solution method for computing solutions associated with an hybrid traffic flow model based on the Lighthill- Whitham-Richards (LWR) partial differential equation. In this hybrid flow model, the vehicles satisfy the LWR equation whenever possible, and have a fixed acceleration otherwise. We first present a grid-free solution method for the LWR equation based on the minimization of component functions. We then show that this solution method can be extended to compute the solutions to the hybrid model by proper modification of the component functions, for any concave fundamental diagram. We derive these functions analytically for the specific case of a triangular fundamental diagram. We also show that the proposed computational method can handle fixed or moving bottlenecks.

Applications of accelerator mass spectrometry to nuclear physics and astrophysics

International Nuclear Information System (INIS)

Guo Zhiyu; Zhang Chuan

2002-01-01

As an ultra high sensitive analyzing method, accelerator mass spectrometry is playing an important role in the studies of nuclear physics and astrophysics. The accelerator mass spectrometry (AMS) applications in searching for violation of Pauli exclusion principle and study on supernovae are discussed as examples

Quantitation of Acrylamide in Foods by High-Resolution Mass Spectrometry

NARCIS (Netherlands)

Troise, A.D.; Fogliano, Vincenzo

2016-01-01

The use of liquid chromatography high-resolution mass spectrometry (LC-HRMS) and direct analysis real-time high-resolution mass spectrometry (DART-HRMS) defines a new scenario in the analysis of thermal-induced toxicants, such as acrylamide. Several factors contribute to the definition of the

Analytical mass spectrometry. Abstracts

Energy Technology Data Exchange (ETDEWEB)

1990-12-31

This 43rd Annual Summer Symposium on Analytical Chemistry was held July 24--27, 1990 at Oak Ridge, TN and contained sessions on the following topics: Fundamentals of Analytical Mass Spectrometry (MS), MS in the National Laboratories, Lasers and Fourier Transform Methods, Future of MS, New Ionization and LC/MS Methods, and an extra session. (WET)

Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry

Energy Technology Data Exchange (ETDEWEB)

Kyle, Jennifer E.; Zhang, Xing; Weitz, Karl K.; Monroe, Matthew E.; Ibrahim, Yehia M.; Moore, Ronald J.; Cha, Jeeyeon; Sun, Xiaofei; Lovelace, Erica S.; Wagoner, Jessica; Polyak, Steve; Metz, Thomas O.; Dey, Sudhansu K.; Smith, Richard D.; Burnum-Johnson, Kristin E.; Baker, Erin Shammel

2016-01-01

Understanding how biological molecules are generated, metabolized and eliminated in living systems is important for interpreting processes such as immune response and disease pathology. While genomic and proteomic studies have provided vast amounts of information over the last several decades, interest in lipidomics has also grown due to improved analytical technologies revealing altered lipid metabolism in type 2 diabetes, cancer, and lipid storage disease. Liquid chromatography and mass spectrometry (LC-MS) measurements are currently the dominant approach for characterizing the lipidome by providing detailed information on the spatial and temporal composition of lipids. However, interpreting lipids’ biological roles is challenging due to the existence of numerous structural and stereoisomers (i.e. distinct acyl chain and double-bond positions), which are unresolvable using present LC-MS approaches. Here we show that combining structurally-based ion mobility spectrometry (IMS) with LC-MS measurements distinguishes lipid isomers and allows insight into biological and disease processes.

Initial Gamma Spectrometry Examination of the AGR-3/4 Irradiation

Energy Technology Data Exchange (ETDEWEB)

Harp, Jason M.; Demkowicz, Paul A.; Stempien, John D.

2016-11-01

The initial results from gamma spectrometry examination of the different components from the combined third and fourth US Advanced Gas Reactor Fuel Development TRISO-coated particle fuel irradiation tests (AGR-3/4) have been analyzed. This experiment was designed to provide information about in-pile fission product migration. In each of the 12 capsules, a single stack of four compacts with designed-to-fail particles surrounded by two graphitic diffusion rings (inner and outer) and a graphite sink were irradiated in the Idaho National Laboratory’s Advanced Test Reactor. Gamma spectrometry has been used to evaluate the gamma-emitting fission product inventory of compacts from the irradiation and evaluate the burnup of these compacts based on the activity of the radioactive cesium isotopes (Cs-134 and Cs-137) in the compacts. Burnup from gamma spectrometry compares well with predicted burnup from simulations. Additionally, inner and outer rings were also examined by gamma spectrometry both to evaluate the fission product inventory and the distribution of gamma-emitting fission products within the rings using gamma emission computed tomography. The cesium inventory of the scanned rings compares acceptably well with the expected inventory from fission product transport modeling. The inventory of the graphite fission product sinks is also being evaluated by gamma spectrometry.

Detector calibration for in-situ gamma ray spectrometry

CERN Document Server

Balea, G

2002-01-01

The power in the technique of in-situ spectrometry lies in the fact that a detector placed on ground measures gamma radiation from sources situated over an area of several hundred square meters. The 'field of view' for the detector would be larger for high energy radiation sources and for sources closer to the soil surface. In contrast, a soil sample would represent an area of a few tens of hundreds of square centimeters. In practice, an effective characterization of a site would involve in-situ gamma ray spectrometry in conjunction with soil sampling. As part of an overall program, in-situ gamma ray spectrometry provides a means to assess the degree of contamination in areas during the course of operations in the field, thus guiding the investigator on where to collect samples. It can also substantially reduce the number of samples need to be collected and subsequently analyzed. (author)

Atomic fluorescence spectrometry with the inductively coupled plasma

International Nuclear Information System (INIS)

Omenetto, N.; Winefordner, J.D.

1987-01-01

Atomic fluorescence spectrometry (AFS) is based on the radiational activation of atoms and ions produced in a suitable atomizer (ionizer) and the subsequent measurement of the resulting radiational deactivation, called fluorescence. Atomic fluorescence spectrometry has been of considerable interest to researchers in atomic spectrometry because of its use for both analytical and diagnostic purposes. Unfortunately, the analytical applications of AFS have suffered from the lack of commercial instrumentation until the recent marketing of the Baird multiple-element, hollow cathode lamp-excited inductively coupled plasma system. This chapter is concerned strictly with the use of the inductively coupled plasma (ICP) as a cell and as a source for AFS. Many of the major references concerning the ICP in analytical AFS are categorized in Table 9.1, along with several reviews and diagnostical studies. For more detailed discussions of the fundamental aspects of AFS, the reader is referred to previous reviews

NICHD Biomedical Mass Spectrometry Core Facility

Data.gov (United States)

Federal Laboratory Consortium — The NICHD Biomedical Mass Spectrometry Core Facility was created under the auspices of the Office of the Scientific Director to provide high-end mass-spectrometric...

Hands-on Electrospray Ionization-Mass Spectrometry for Upper-Level Undergraduate and Graduate Students

Science.gov (United States)

Stock, Naomi L.; March, Raymond E.

2014-01-01

Electrospray ionization-mass spectrometry (ESI-MS) is a powerful technique for the detection, identification, and quantification of organic compounds. As mass spectrometers have become more user-friendly and affordable, many students--often with little experience in mass spectrometry--find themselves needing to incorporate mass spectrometry into…

Mass spectrometry in epigenetic research

DEFF Research Database (Denmark)

Beck, Hans Christian

2010-01-01

cancers has gained tremendous interest in recent years, and many of these inhibitors are currently undergoing clinical trials. Despite intense research, however, the exact molecular mechanisms of action of these molecules remain, to a wide extent, unclear. The recent application of mass spectrometry...

Analysis of mass spectrometry data in proteomics

DEFF Research Database (Denmark)

Matthiesen, Rune; Jensen, Ole N

2008-01-01

The systematic study of proteins and protein networks, that is, proteomics, calls for qualitative and quantitative analysis of proteins and peptides. Mass spectrometry (MS) is a key analytical technology in current proteomics and modern mass spectrometers generate large amounts of high-quality data...... that in turn allow protein identification, annotation of secondary modifications, and determination of the absolute or relative abundance of individual proteins. Advances in mass spectrometry-driven proteomics rely on robust bioinformatics tools that enable large-scale data analysis. This chapter describes...... some of the basic concepts and current approaches to the analysis of MS and MS/MS data in proteomics....

Automatic gamma spectrometry analytical apparatus

International Nuclear Information System (INIS)

Lamargot, J.-P.; Wanin, Maurice.

1980-01-01

This invention falls within the area of quantitative or semi-quantitative analysis by gamma spectrometry and particularly refers to a device for bringing the samples into the counting position. The purpose of this invention is precisely to provide an automatic apparatus specifically adapted to the analysis of hard gamma radiations. To this effect, the invention relates to a gamma spectrometry analytical device comprising a lead containment, a detector of which the sensitive part is located inside the containment and additionally comprising a transfer system for bringing the analyzed samples in succession to a counting position inside the containment above the detector. A feed compartment enables the samples to be brought in turn one by one on to the transfer system through a duct connecting the compartment to the transfer system. Sequential systems for the coordinated forward feed of the samples in the compartment and the transfer system complete this device [fr

New experiments in organic, fast-atom-bomdardment, and secondary-ion mass spectrometry

International Nuclear Information System (INIS)

DiDonato, G.C.

1987-01-01

The goal of research presented in this dissertation is the creative use of new ionization and instrumental techniques in mass spectrometry. This goal manifests itself in three areas of mass spectrometry. In the first portion, modern, state-of-the-art instrumentation and new experiments were used to re-examine the mass spectra of transition-metal acetates and acetylacetonates. High resolution, chemical ionization, negative chemical ionization, and extended-mass-range mass spectrometry uncovered a wealth of new gas-phase ionic species. Energy-resolved mass spectrometry/mass spectrometry was applied to the characterization of molecular and fragment ion first-row transition-metal acetylacetonates, and comprises the second portion of the thesis. Studies in fast-atom-bombardment mass spectrometry are the subject of the third portion of the dissertation. Since fast-atom bombardment samples a liquid matrix, absolute and relative abundances of sputtered secondary ions are influenced by solution chemistry. The design and construction of an imaging secondary-ion mass spectrometer is the subject of the final portion of the thesis. This instrument provides for direct mass-spectrometric analysis of thin-layer and paper chromatograms and electrophoretograms

Laser mass spectrometry for DNA sequencing, disease diagnosis, and fingerprinting

Energy Technology Data Exchange (ETDEWEB)

Winston Chen, C.H.; Taranenko, N.I.; Zhu, Y.F.; Chung, C.N.; Allman, S.L.

1997-03-01

Since laser mass spectrometry has the potential for achieving very fast DNA analysis, the authors recently applied it to DNA sequencing, DNA typing for fingerprinting, and DNA screening for disease diagnosis. Two different approaches for sequencing DNA have been successfully demonstrated. One is to sequence DNA with DNA ladders produced from Snager`s enzymatic method. The other is to do direct sequencing without DNA ladders. The need for quick DNA typing for identification purposes is critical for forensic application. The preliminary results indicate laser mass spectrometry can possibly be used for rapid DNA fingerprinting applications at a much lower cost than gel electrophoresis. Population screening for certain genetic disease can be a very efficient step to reducing medical costs through prevention. Since laser mass spectrometry can provide very fast DNA analysis, the authors applied laser mass spectrometry to disease diagnosis. Clinical samples with both base deletion and point mutation have been tested with complete success.

Da Chrétien de Troyes a Shakespeare («The tragedy of King Richard the Third», a. I, sc. 2

Directory of Open Access Journals (Sweden)

Alfonso D'Agostino

2015-07-01

Full Text Available L’articolo si propone di considerare le somiglianze fra alcune vicende antico-francesi (l’Yvain di Chrétien de Troyes e il fabliau anonimo De celle que se fist foutre sur la fosse son mari con una scena del Riccardo III di Shakespeare. Anche se non si può dire che il dramma inglese dipenda dai testi narrativi oitanici, esso sviluppa lo stesso motivo della vedova consolata e una serie di motivi secondarî, di immagini (il sangue, il diavolo, la seduzione e di espressioni letterarie in modo sintomaticamente affine. The paper aims to evaluate similarities between some Old-French narratives (Chrétien de Troyes’ Yvain and the anonymous fabliau De celle que se fist foutre sur la fosse son mari and a scene from Shakespeare’s Richard III. Although we cannot affirm that Shakespeare’s play derives from the French narratives, it develops the same theme of “comforted widow” along with a series of secondary themes, of images (the blood, the devil, the seduction and literary expressions in a symptomatically, very similar way.

Radiation Biomarker Research Using Mass Spectrometry

National Research Council Canada - National Science Library

Bach, Stephan B; Hubert, Walter

2007-01-01

.... This review is intended to give an overview of mass spectrometry and its application to biological systems and biomarker discovery and how that might relate to relevant radiation dosimetry studies...

Recent trends in atomic spectrometry with microwave-induced plasmas

International Nuclear Information System (INIS)

Broekaert, Jose A.C.; Siemens, Volker

2004-01-01

The state-of-the-art and trends of development in atomic spectrometry with microwave-induced plasmas (MIPs) since the 1998s are presented and discussed. This includes developments in devices for producing microwave plasma discharges, with reference also to miniaturized systems as well as to progress in sample introduction for microwave-induced plasmas, such as pneumatic and ultrasonic nebulization using membrane desolvation, to the further development of gaseous analyte species generation systems and to both spark and laser ablation (LA). The features of microwave-induced plasma mass spectrometry (MIP-MS) as an alternative to inductively coupled plasma (ICP)-MS are discussed. Recent work on the use of microwave-induced plasma atomic spectrometry for trace element determinations and monitoring, their use as tandem sources and for particle sizing are discussed. Recent applications of the coupling of gas chromatography and MIP atomic spectrometry for the determination of organometallic compounds of heavy metals such as Pb, Hg, Se and Sn are reviewed and the possibilities of trapping for sensitivity enhancement, as required for many applications especially in environmental work, are showed at the hand of citations from the recent literature

Mass spectrometry with particle accelerator

International Nuclear Information System (INIS)

Anon.

1983-01-01

The heavy ion accelerator use is renewing the ultrasensitive mass spectrometry in extending the detection limits. These new devices allow the measurement of rare isotope ratio, as 10 Be, 14 C, 26 Al, 36 Cl or 41 Ca, from the earth natural reservoirs [fr

Identification of keratinocyte specific markers using phage display and mass spectrometry

DEFF Research Database (Denmark)

Jensen, K.B.; Jensen, O.N.; Ravn, P.

2003-01-01

and mass spectrometry that allows identification of cell type-specific protein markers. The most important features of the method are (i) reduction of experimental noise originating from background binding of phage particles and (ii) isolation of affinity binders after a single round of selection, which...... antigens were subsequently identified by mass spectrometry as laminin-5, plectin, and fibronectin. The combination of phage display technology with mass spectrometry methods for protein identification is a general and promising approach for proteomic analysis of cell surface complexity....

Determination of mercury in hair: Comparison between gold amalgamation-atomic absorption spectrometry and mass spectrometry.

Science.gov (United States)

Domanico, Francesco; Forte, Giovanni; Majorani, Costanza; Senofonte, Oreste; Petrucci, Francesco; Pezzi, Vincenzo; Alimonti, Alessandro

2017-09-01

Mercury is a heavy metal that causes serious health problems in exposed subjects. The most toxic form, i.e., methylmercury (MeHg), is mostly excreted through human hair. Numerous analytical methods are available for total Hg analysis in human hair, including cold vapour atomic fluorescence spectrometry (CV-AFS), inductively coupled plasma mass spectrometry (ICP-MS) and thermal decomposition amalgamation atomic absorption spectrometry (TDA-AAS). The aim of the study was to compare the TDA-AAS with the ICP-MS in the Hg quantification in human hair. After the washing procedure to minimize the external contamination, from each hair sample two aliquots were taken; the first was used for direct analysis of Hg by TDA-AAS and the second was digested for Hg determination by the ICP-MS. Results indicated that the two data sets were fully comparable (median; TDA-AAS, 475ngg -1 ; ICP-MS, 437ngg -1 ) and were not statistically different (Mann-Whitney test; p=0.44). The two techniques presented results with a good coefficient of correlation (r=0.94) despite different operative ranges and method limits. Both techniques satisfied internal performance requirements and the parameters for method validation resulting sensitive, precise and reliable. Finally, the use of the TDA-AAS can be considered instead of the ICP-MS in hair analysis in order to reduce sample manipulation with minor risk of contamination, less time consuming due to the absence of the digestion step and cheaper analyses. Copyright © 2016 Elsevier GmbH. All rights reserved.

Analysis of posttranslational modifications of proteins by tandem mass spectrometry

DEFF Research Database (Denmark)

Larsen, Martin Røssel; Trelle, Morten B; Thingholm, Tine E

2006-01-01

-temporal distribution in cells and tissues. Most PTMs can be detected by protein and peptide analysis by mass spectrometry (MS), either as a mass increment or a mass deficit relative to the nascent unmodified protein. Tandem mass spectrometry (MS/MS) provides a series of analytical features that are highly useful...

Janus probe, a detection system for high energy reactor gamma-ray spectrometry

International Nuclear Information System (INIS)

Gold, R.; Kaiser, B.J.

1980-03-01

In reactor environments, gamma-ray spectra are continuous and the absolute magnitude as well as the general shape of the gamma continuum are of paramount importance. Consequently, conventional methods of gamma-ray detection are not suitable for in-core gamma-ray spectrometry. To meet these specific needs, a method of continuous gamma-ray spectrometry, namely Compton Recoil Gamma-Ray Spectrometry, was developed for in-situ observations of reactor environments. A new gamma-ray detection system has been developed which extends the applicability of Compton Recoil Gamma-Ray Spectrometry up to roughly 7 MeV. This detection system is comprised of two separate Si(Li) detectors placed face-to-face. Hence this new detection system is called the Janus probe. Also shown is the block diagram of pulse processing instrumentation for the Janus probe. This new gamma probe not only extends the upper energy limit of in-core gamma-ray spectrometry, but in addition possesses other fundamental advantages

Probing the Composition, Assembly and Activity of Protein Molecular Machines using Native Mass Spectrometry

NARCIS (Netherlands)

van de Waterbeemd, M.J.

2017-01-01

Native mass spectrometry and mass spectrometry in general, are powerful analytical tools for studying proteins and protein complexes. Native mass spectrometry may provide accurate mass measurements of large macromolecular assemblies enabling the investigation of their composition and stoichiometry.

A mass spectrometry proteomics data management platform.

Science.gov (United States)

Sharma, Vagisha; Eng, Jimmy K; Maccoss, Michael J; Riffle, Michael

2012-09-01

Mass spectrometry-based proteomics is increasingly being used in biomedical research. These experiments typically generate a large volume of highly complex data, and the volume and complexity are only increasing with time. There exist many software pipelines for analyzing these data (each typically with its own file formats), and as technology improves, these file formats change and new formats are developed. Files produced from these myriad software programs may accumulate on hard disks or tape drives over time, with older files being rendered progressively more obsolete and unusable with each successive technical advancement and data format change. Although initiatives exist to standardize the file formats used in proteomics, they do not address the core failings of a file-based data management system: (1) files are typically poorly annotated experimentally, (2) files are "organically" distributed across laboratory file systems in an ad hoc manner, (3) files formats become obsolete, and (4) searching the data and comparing and contrasting results across separate experiments is very inefficient (if possible at all). Here we present a relational database architecture and accompanying web application dubbed Mass Spectrometry Data Platform that is designed to address the failings of the file-based mass spectrometry data management approach. The database is designed such that the output of disparate software pipelines may be imported into a core set of unified tables, with these core tables being extended to support data generated by specific pipelines. Because the data are unified, they may be queried, viewed, and compared across multiple experiments using a common web interface. Mass Spectrometry Data Platform is open source and freely available at http://code.google.com/p/msdapl/.

Determination of ultra-low levels of uranium using resonance ionization mass spectrometry

International Nuclear Information System (INIS)

Kiran Kumar, P.V.; Acharyulu, G.V.S.G.

2015-01-01

The determination of isotopic composition of actinides like U and Pu is important, due to their distribution in the environment as a result of nuclear weapons testing, fuel reprocessing, reactor operations and to a smaller extent from accidental releases. The analytical methods like fission track analysis (FTA), thermal ionization mass spectrometry (TIMS), inductively coupled plasma mass spectrometry (ICPMS) and resonance ionization mass spectrometry (RIMS) have evolved as sensitive techniques. Resonance Ionization Mass Spectrometry yields rapid isotopic signature data for material containing actinides without requiring time-consuming sample preparation and chemical separation procedures. In this paper, authors presented the details of the methodology and results for low-level detection of uranium using RIMS

Monitoring of an esterification reaction by on-line direct liquid sampling mass spectrometry and in-line mid infrared spectrometry with an attenuated total reflectance probe

International Nuclear Information System (INIS)

Owen, Andrew W.; McAulay, Edith A.J.; Nordon, Alison; Littlejohn, David; Lynch, Thomas P.; Lancaster, J. Steven; Wright, Robert G.

2014-01-01

Highlights: • High efficiency thermal vaporiser designed and used for on-line reaction monitoring. • Concentration profiles of all reactants and products obtained from mass spectra. • By-product formed from the presence of an impurity detected by MS but not MIR. • Mass spectrometry can detect trace and bulk components unlike molecular spectrometry. - Abstract: A specially designed thermal vaporiser was used with a process mass spectrometer designed for gas analysis to monitor the esterification of butan-1-ol and acetic anhydride. The reaction was conducted at two scales: in a 150 mL flask and a 1 L jacketed batch reactor, with liquid delivery flow rates to the vaporiser of 0.1 and 1.0 mL min −1 , respectively. Mass spectrometry measurements were made at selected ion masses, and classical least squares multivariate linear regression was used to produce concentration profiles for the reactants, products and catalyst. The extent of reaction was obtained from the butyl acetate profile and found to be 83% and 76% at 40 °C and 20 °C, respectively, at the 1 L scale. Reactions in the 1 L reactor were also monitored by in-line mid-infrared (MIR) spectrometry; off-line gas chromatography (GC) was used as a reference technique when building partial least squares (PLS) multivariate calibration models for prediction of butyl acetate concentrations from the MIR spectra. In validation experiments, good agreement was achieved between the concentration of butyl acetate obtained from in-line MIR spectra and off-line GC. In the initial few minutes of the reaction the profiles for butyl acetate derived from on-line direct liquid sampling mass spectrometry (DLSMS) differed from those of in-line MIR spectrometry owing to the 2 min transfer time between the reactor and mass spectrometer. As the reaction proceeded, however, the difference between the concentration profiles became less noticeable. DLSMS had advantages over in-line MIR spectrometry as it was easier to generate

Fourier transform ion cyclotron resonance mass spectrometry

Science.gov (United States)

Marshall, Alan G.

1998-06-01

As for Fourier transform infrared (FT-IR) interferometry and nuclear magnetic resonance (NMR) spectroscopy, the introduction of pulsed Fourier transform techniques revolutionized ion cyclotron resonance mass spectrometry: increased speed (factor of 10,000), increased sensitivity (factor of 100), increased mass resolution (factor of 10,000-an improvement not shared by the introduction of FT techniques to IR or NMR spectroscopy), increased mass range (factor of 500), and automated operation. FT-ICR mass spectrometry is the most versatile technique for unscrambling and quantifying ion-molecule reaction kinetics and equilibria in the absence of solvent (i.e., the gas phase). In addition, FT-ICR MS has the following analytically important features: speed (~1 second per spectrum); ultrahigh mass resolution and ultrahigh mass accuracy for analysis of mixtures and polymers; attomole sensitivity; MSn with one spectrometer, including two-dimensional FT/FT-ICR/MS; positive and/or negative ions; multiple ion sources (especially MALDI and electrospray); biomolecular molecular weight and sequencing; LC/MS; and single-molecule detection up to 108 Dalton. Here, some basic features and recent developments of FT-ICR mass spectrometry are reviewed, with applications ranging from crude oil to molecular biology.

Mass Spectrometry Applications for Toxicology.

Science.gov (United States)

Mbughuni, Michael M; Jannetto, Paul J; Langman, Loralie J

2016-12-01

Toxicology is a multidisciplinary study of poisons, aimed to correlate the quantitative and qualitative relationships between poisons and their physiological and behavioural effects in living systems. Other key aspects of toxicology focus on elucidation of the mechanisms of action of poisons and development of remedies and treatment plans for associated toxic effects. In these endeavours, Mass spectrometry (MS) has become a powerful analytical technique with a wide range of application used in the Toxicological analysis of drugs, poisons, and metabolites of both. To date, MS applications have permeated all fields of toxicology which include; environmental, clinical, and forensic toxicology. While many different analytical applications are used in these fields, MS and its hyphenated applications such as; gas chromatography MS (GC-MS), liquid chromatography MS (LC-MS), inductively coupled plasma ionization MS (ICP-MS), tandem mass spectrometry (MS/MS and MS n ) have emerged as powerful tools used in toxicology laboratories. This review will focus on these hyphenated MS technologies and their applications for toxicology.

Mass Spectrometry Applications for Toxicology

Science.gov (United States)

Mbughuni, Michael M.; Jannetto, Paul J.

2016-01-01

Toxicology is a multidisciplinary study of poisons, aimed to correlate the quantitative and qualitative relationships between poisons and their physiological and behavioural effects in living systems. Other key aspects of toxicology focus on elucidation of the mechanisms of action of poisons and development of remedies and treatment plans for associated toxic effects. In these endeavours, Mass spectrometry (MS) has become a powerful analytical technique with a wide range of application used in the Toxicological analysis of drugs, poisons, and metabolites of both. To date, MS applications have permeated all fields of toxicology which include; environmental, clinical, and forensic toxicology. While many different analytical applications are used in these fields, MS and its hyphenated applications such as; gas chromatography MS (GC-MS), liquid chromatography MS (LC-MS), inductively coupled plasma ionization MS (ICP-MS), tandem mass spectrometry (MS/MS and MSn) have emerged as powerful tools used in toxicology laboratories. This review will focus on these hyphenated MS technologies and their applications for toxicology. PMID:28149262

Determination of trace elements in soy milk using ICP atomic emission spectrometry

International Nuclear Information System (INIS)

Tanaka, Satoko; Chayama, Kenji

2009-01-01

The present study investigated the optimal method for the multi-element quantification of 9 elements in soy milk: calcium, copper, iron, potassium, magnesium, manganese, sodium, phosphorus, and zinc. Results obtained using ICP atomic emission spectrometry were compared with those obtained by atomic absorption spectrometry, which is the standard method. The same sample was measured using both ICP atomic emission spectrometry and atomic absorption spectrometry. The percentage of minerals recovered by ICP atomic emission spectrometry ranged from 99.3% to 102%, which was equivalent to that by atomic absorption spectrometry. Therefore, a good result with standard deviation was obtained. The mineral contents of 16 samples of commercially-available soy milk products were measured. The Cu content was significantly proportional to the amount of soybean solids (P < 0.001). Moreover, although relation-ships did not attain statistical significance, the consents of Fe, Zn, K, Mg and P were proportional to the amount of soybean solids, and were highest in soy milk, followed by prepared soy milk and so milk beverage. The Ca content of modified soy milk was significantly higher than that of soy milk and soy milk-based beverages (P < 0.001). Furthermore, the Na content in soy milk was significantly lower. (author)

Chemical analysis of refractories by plasma spectrometry

International Nuclear Information System (INIS)

Coutinho, C.A.

1990-01-01

X-ray spectrometry has been, since the last two or three decades, the traditional procedure for the chemical analysis of refractories, due to its high degree of accuracy and speed to produce analytical results. An interesting alternative to X-ray fluorescence is provided by the Inductively Coupled Plasma Spectrometry technique, for those laboratories where wet chemistry facilities are already available or process control is not required at high speed, or investiment costs have to be low. This paper presents results obtained by plasma spectroscopy for the analysis of silico - aluminous refractories, showing calibration curves, precion and detection limits. Considerations and comparisons with X-ray fluorescence are also made. (author) [pt

Mass Spectrometry in the Home and Garden

Science.gov (United States)

Pulliam, Christopher J.; Bain, Ryan M.; Wiley, Joshua S.; Ouyang, Zheng; Cooks, R. Graham

2015-02-01

Identification of active components in a variety of chemical products used directly by consumers is described at both trace and bulk levels using mass spectrometry. The combination of external ambient ionization with a portable mass spectrometer capable of tandem mass spectrometry provides high chemical specificity and sensitivity as well as allowing on-site monitoring. These experiments were done using a custom-built portable ion trap mass spectrometer in combination with the ambient ionization methods of paper spray, leaf spray, and low temperature plasma ionization. Bactericides, garden chemicals, air fresheners, and other products were examined. Herbicide applied to suburban lawns was detected in situ on single leaves 5 d after application.

Contribution of photoelectron spectrometry and infrared spectrometry to the study of various oxidised forms of chromium

International Nuclear Information System (INIS)

Feve, L.

1985-03-01

Securate knowledge of internal surface of primary coolant circuits of PWR is required for an estimation of dissolution of used materials and for estimation of decontamination efficiency. The binding energies of various electron levels of chromium were determined by photoelectron spectrometry (ESCA), both for the metal and for certain compounds. Because of the intensities of the signals obtained the 2 p 3/2 level alone can be used for analytical purposes. Owing to a possible interference between this level due to hexavalent chromium and a satellite peak caused by trivalent chromium the method is not able to show up small amounts of chromium VI in chromium III. Simultaneous detection of the hexavalent and trivalent forms was achieved by infrared spectrometry. The problem of revealing traces of chromium VI in surface layers of trivalent chromium oxide has thus been solved [fr

Atom counting with accelerator mass spectrometry

International Nuclear Information System (INIS)

Kutschera, Walter

1995-01-01

A brief review of the current status and some recent applications of accelerator mass spectrometry (AMS) are presented. Some connections to resonance ionization mass spectroscopy (RIS) as the alternate atom counting method are discussed

Critical evaluation of analytical performance of atomic absorption spectrometry and inductively coupled plasma mass spectrometry for mercury determination

International Nuclear Information System (INIS)

Krata, A.; Bulska, E.

2005-01-01

The analytical performance of cold vapor atomic absorption spectrometry (CV AAS), graphite furnace atomic absorption spectrometry (GF AAS) and inductively coupled plasma mass spectrometry (ICP-MS) for mercury determination have been investigated with the use of two reference materials SRM 2710 Montana I Soil and BCR-144R (sewage sludge from domestic origin). The digestion conditions and their influence on determination of mercury have been studied. Samples were decomposed by microwave digestion in closed vessels with the use of HCl alone or mixture of HCl+HNO 3 +HF. The digestion solutions were analyzed by CV AAS using NaBH 4 as a reducing agent, by GF AAS with Pd or mixture of Pd/Rh as modifiers and by ICP-MS with Rh as internal standard. In the case of CV AAS, results were not dependent on digestion conditions. In the case of GF AAS and ICP-MS, results depended significantly on digestion conditions; in both cases, the use of the mixture of acids as defined above suppressed the signal of mercury. Therefore, in those cases, the microwave digestion with HCl is recommended. Detection limits of 0.003, 0.01 and 0.2 μg g -1 were achieved by ICP-MS, CV AAS and GF AAS, respectively

An introduction to the technique of combined ion mobility spectrometry-mass spectrometry for the analysis of complex biological samples

International Nuclear Information System (INIS)

McDowall, Mark A.; Bateman, Robert H.; Bajic, Steve; Giles, Kevin; Langridge, Jim; McKenna, Therese; Pringle, Steven D.; Wildgoose, Jason L.

2008-01-01

Full Text: Ultra Performance Liquid Chromatography (UPLC) offers several advantages compared with conventional High Performance Liquid Chromatography (HPLC) as an 'inlet system' for mass spectrometry. UPLC provides improved chromatographic resolution, increased sensitivity and reduced analysis time. This is achieved through the use of sub 2μm particles (stationary phase) combined with high-pressure solvent delivery (up to 15,000 psi). When coupled with orthogonal acceleration time-of-flight (oa-TOF) mass spectrometry (MS), UPLC presents a means to achieve high sample throughput with reduced spectral overlap, increased sensitivity, and exact mass measurement capabilities with high mass spectral resolution (Ca 20,000 FWHM). Dispersive ion mobility spectrometry (IMS) implemented within a traveling-wave ion guide provides an orthogonal separation strategy for ions in the gas phase that can resolve isobaric ions formed by either Electrospray of MALDI ionization typically in Ca 20 mille seconds. All three techniques have the potential to be combined on-line (e.g. UPLC-IMS-MS/MS) in real time to maximize peak capacity and resolving power for the analysis of complex biological mixtures including; intact proteins, modified peptides and endogenous/exogenous metabolites

A differential mobility spectrometry/mass spectrometry platform for the rapid detection and quantitation of DNA adduct dG-ABP.

Science.gov (United States)

Kafle, Amol; Klaene, Joshua; Hall, Adam B; Glick, James; Coy, Stephen L; Vouros, Paul

2013-07-15

There is continued interest in exploring new analytical technologies for the detection and quantitation of DNA adducts, biomarkers which provide direct evidence of exposure and genetic damage in cells. With the goal of reducing clean-up steps and improving sample throughput, a Differential Mobility Spectrometry/Mass Spectrometry (DMS/MS) platform has been introduced for adduct analysis. A DMS/MS platform has been utilized for the analysis of dG-ABP, the deoxyguanosine adduct of the bladder carcinogen 4-aminobiphenyl (4-ABP). After optimization of the DMS parameters, each sample was analyzed in just 30 s following a simple protein precipitation step of the digested DNA. A detection limit of one modification in 10^6 nucleosides has been achieved using only 2 µg of DNA. A brief comparison (quantitative and qualitative) with liquid chromatography/mass spectrometry is also presented highlighting the advantages of using the DMS/MS method as a high-throughput platform. The data presented demonstrate the successful application of a DMS/MS/MS platform for the rapid quantitation of DNA adducts using, as a model analyte, the deoxyguanosine adduct of the bladder carcinogen 4-aminobiphenyl. Copyright © 2013 John Wiley & Sons, Ltd.

New developments in glow discharge optical emission and mass spectrometry

International Nuclear Information System (INIS)

Hoffmann, Volker; Dorka, Roland; Wilken, Ludger; Wetzig, Klaus

2000-01-01

This paper describes new developments in flow discharge optical emission (GD-OES) and mass spectrometry (GD-MS) at IFW and presents corresponding new applications (analysis of microelectronic multi-layer system by radio frequency glow discharge optical emission spectrometry (RF-GD-OES) and analysis of pure iron by a new Grimm-type GD-MS source)

Symposium on fast atom and ion induced mass spectrometry of nonvolatile organic solids

International Nuclear Information System (INIS)

McNeal, C.J.

1982-01-01

The mechanisms of molecular and fragment ion production and the various parameters affecting ion yields were discussed by 6 invited speakers from Europe, Canada, and the US at this symposium. The work reported was almost equally divided between that using low-energy (keV) primary ion (or atom) beams, e.g. fast atom bombardment mass spectrometry (FABMS) and secondary ion mass spectrometry (SIMS) and that using high energy (MeV) particles, e.g. heavy ion induced mass spectrometry (HIIDMS) and 252 Cf-plasma desorption mass spectrometry ( 252 Cf-PDMS). Both theoretical foundations and observed experimental results for both techniques are included

Paradigms in isotope dilution mass spectrometry for elemental speciation analysis

International Nuclear Information System (INIS)

Meija, Juris; Mester, Zoltan

2008-01-01

Isotope dilution mass spectrometry currently stands out as the method providing results with unchallenged precision and accuracy in elemental speciation. However, recent history of isotope dilution mass spectrometry has shown that the extent to which this primary ratio measurement method can deliver accurate results is still subject of active research. In this review, we will summarize the fundamental prerequisites behind isotope dilution mass spectrometry and discuss their practical limits of validity and effects on the accuracy of the obtained results. This review is not to be viewed as a critique of isotope dilution; rather its purpose is to highlight the lesser studied aspects that will ensure and elevate current supremacy of the results obtained from this method

Multidimensional chromatography coupled to mass spectrometry in analysing complex proteomics samples

NARCIS (Netherlands)

Horvatovich, Peter; Hoekman, Berend; Govorukhina, Natalia; Bischoff, Rainer

Multidimensional chromatography coupled to mass spectrometry (LC(n)-MS) provides more separation power and an extended measured dynamic concentration range to analyse complex proteomics samples than one dimensional liquid chromatography coupled to mass spectrometry (1D-LC-MS). This review gives an

Determination of uranium in seawater by fluorescence spectrometry

International Nuclear Information System (INIS)

Kawashima, Toshi; Kawakubo, Senkichi; Minegishi, Hisako.

1984-01-01

A Fluorescence spectrometry for the determination of uranium in seawater has been developed. Anion exchange separation of uranium from seawater followed by preparation of NaF-carbonate cake and by spectrometry for ultraviolet ray excited fluorescence of uranium on the fluoride host provide the trace determinaton of uranium at the subnano gram level. Anion exchange behavior, excitation-emission behavior of the uranium on the host and effects of foreign ions to the fluorescence have been presented. Appling the method to 1 ml of seawater 3 ppb of uranium has been determined. (author)

Technical and economical aspects of mass spectrometry in food and agricultural industries

International Nuclear Information System (INIS)

Cornu, Ayme

1975-01-01

Mass spectrometry proved to be very useful for solving analytical problems in food and agricultural industries. Its essential properties are: high resolution mass spectrometry allows to find the molecular structure of an isolated compound, even with a very small sample; associated with on line gas chromatographic separation, it gives the possibility to identify a great number of components in a small complex extract; isotope determinations by mass spectrometry give an essential contribution to follow kinetic mechanisms of formation of natural molecules in plant-growing, photosynthesis, fertilization, ..., leading to identification of the origin of foods and beverages. The economical aspect of mass spectrometry is characterized by the cost of investment in instrumentation and the necessary high level of competence of the technicians [fr

UNA NUEVA ALTERNATIVA NUMÉRICA PARA LA SOLUCIÓN DE LA ECUACIÓN UNIDIMENSIONAL DE RICHARDS: ESTUDIO DE DRENAJE E INFILTRACIÓN DE FLUIDOS EN LA ZONA NO SATURADA

Directory of Open Access Journals (Sweden)

Evelyn Álvarez Sierra

2016-10-01

Full Text Available En el trabajo se comparan dos métodos numéricos para resolver el modelo unidimensional de infiltración y drenaje de agua en la zona no saturada en medios porosos, el cual es modelado respecto al contenido de humedad utilizando la ecuación no-lineal de Richards. El primer método está basado en el método clásico de Diferencias Finitas y el segundo en el método de Líneas combinado con el código DASSL para la solución de las ecuaciones diferenciales-algebraicas resultantes. Se muestra que el último método proporciona una vía numérica eficiente para la solución de problemas de EDPs que tienen un comportamiento singular de shock u ondas viajeras, como es el caso de la ecuación de Richard, los cuales se pueden resolver numéricamente con éxito sólo utilizando esquemas muy estables. Los métodos numéricos discutidos en el trabajo se aplican a dos tipos de suelos reales: Yolo Light Clay y Brindabella Silty Clay Loam, usando las propiedades hidráulicas referidas en Broadbridge y White [16]. Para validar el modelo, se comparan los perfiles de humedad con los resultados reportados por Warrick, Lomen e Islas [18].Igualmente, se demuestra con datos reales la ventaja de resolver numéricamente el comportamiento del flujo unidimensional en la zona no saturada de un medio poroso. Finalmente, el modelo propuesto y los resultados numéricos obtenidos posibilitan brindar un pronóstico sobre la utilización de recursos hídricos para el caso de riego en agricultura y también para el transporte de contaminantes.

Theory of error for target factor analysis with applications to mass spectrometry and nuclear magnetic resonance spectrometry

International Nuclear Information System (INIS)

Malinowski, E.R.

1978-01-01

Based on the theory of error for abstract factor analysis described earlier, a theory of error for target factor analysis is developed. The theory shows how the error in the data matrix mixes with the error in the target test vector. The apparent error in a target test is found to be a vector sum of the real error in the target vector and the real error in the predicted vector. The theory predicts the magnitudes of these errors without requiring any a priori knowledge of the error in the data matrix or the target vector. A reliability function and a spoil function are developed for the purpose of assessing the validity and the worthiness of a target vector. Examples from model data, mass spectrometry and nuclear magnetic resonance spectrometry are presented. (Auth.)

Bayesian Integration and Characterization of Composition C-4 Plastic Explosives Based on Time-of-Flight Secondary Ion Mass Spectrometry and Laser Ablation-Inductively Coupled Plasma Mass Spectrometry

Energy Technology Data Exchange (ETDEWEB)

Mahoney, Christine M.; Kelly, Ryan T.; Alexander, M. L.; Newburn, Matthew K.; Bader, Sydney P.; Ewing, Robert G.; Fahey, Albert J.; Atkinson, David A.; Beagley, Nathaniel

2016-02-25

Key elements regarding the use of non-radioactive ionization sources will be presented as related to explosives detection by mass spectrometry and ion mobility spectrometry. Various non-radioactive ionization sources will be discussed along with associated ionization mechanisms pertaining to specific sample types.

Experiences with large-area frisch grid chambers in low-level alpha spectrometry

Energy Technology Data Exchange (ETDEWEB)

Hoetzl, H.; Winkler, R. (Gesellschaft fuer Strahlen- und Umweltforschung m.b.H. Muenchen, Neuherberg (Germany, F.R.). Inst. fuer Strahlenschutz)

1984-06-15

The properties of parallel-plate gridded ionization chambers with areas of 300 cm/sup 2/, developed by us for alpha spectrometry of samples with low specific alpha activity are reported. Several practical hints for optimum operating conditions are presented. The chambers can be operated routinely at atmospheric pressure for several days, without the need for purification of the gas filling (P10). The minimum detectable activity at 5 MeV is 0.01 pCi, based on 4.65 standard deviations of background and 1000 min counting time. At the GSF Research Center ionization chambers of this type are used for the analysis of natural alpha emitters, as well as of transuranium nuclides in environmental samples by: a) direct alpha spectrometry without any previous treatment of the sample, b) semi-direct spectrometry after removal of organic matter by low-temperature ashing and c) spectrometry after chemical separation. Some typical example of application are given. Furthermore the range of application of the chambers in comparison to semiconductor detectors in the field of low-level alpha spectrometry is discussed.

Experiences with large-area frisch grid chambers in low-level alpha spectrometry

International Nuclear Information System (INIS)

Hoetzl, H.; Winkler, R.

1984-01-01

The properties of parallel-plate gridded ionization chambers with areas of 300 cm 2 , developed by us for alpha spectrometry of samples with low specific alpha activity are reported. Several practical hints for optimum operating conditions are presented. The chambers can be operated routinely at atmospheric pressure for several days, without the need for purification of the gas filling (P10). The minimum detectable activity at 5 MeV is 0.01 pCi, based on 4.65 standard deviations of background and 1000 min counting time. At the GSF Research Center ionization chambers of this type are used for the analysis of natural alpha emitters, as well as of transuranium nuclides in environmental samples by: a) direct alpha spectrometry without any previous treatment of the sample, b) semi-direct spectrometry after removal of organic matter by low-temperature ashing and c) spectrometry after chemical separation. Some typical example of application are given. Furthermore the range of application of the chambers in comparison to semiconductor detectors in the field of low-level alpha spectrometry is discussed. (orig.)

Mass spectrometry in identification of ecotoxicants including chemical and biological warfare agents

International Nuclear Information System (INIS)

Lebedev, Albert T.

2005-01-01

Mass spectrometry is a unique tool to detect and identify trace levels of organic and bioorganic compounds as well as microorganisms in the environment. The range of potential chemical warfare (CW) and biological warfare (BW) agents is very broad. An important advantage of mass spectrometry over other techniques involves potential for full spectrum detection of chemical and biological agents including mid-spectrum materials (i.e. bioactive peptides, toxins, etc.) for which biological approaches are inadequate. Being very fast (seconds and minutes), extremely sensitive (zeptomoles 10 -21 ), and informative (detailed qualitative and quantitative composition of mixtures containing hundreds of chemicals), mass spectrometry is a principal analytical tool at the sites of destruction of CW. Due to its unique features, mass spectrometry is applied not only for the detection of CW agents, but for the analysis of products of metabolism and degradation of these agents in organisms or environment as well. The present paper deals with some examples of successful application of mass spectrometry for the analyses of ecotoxicants, chemical warfare agents, explosives, and microorganisms including biology warfare agents

Visiting Richard Serra’s Promenade sculpture improves postural control and judgment of subjective visual vertical.

Directory of Open Access Journals (Sweden)

Zoï eKapoula

2014-12-01

Full Text Available Body sway while maintaining an upright quiet stance reflects an active process of balance based on the integration of visual, vestibular, somatosensory and proprioceptive inputs. Richard Serra’s Promenade sculpture featured in the 2008 Monumenta exhibition at the Grand Palais in Paris, France is herein hypothesised to have stimulated the body’s vertical and longitudinal axes as it showcased 5 monumental rectangular solids pitched at a 1.69° angle.Using computerised dynamic posturography we measured the body sway of 23 visitors when fixating a cross, or when observing the artwork (fixating it or actively exploring it with eye movements before and after walking around and alongside the sculpture (i.e., before and after a promenade. A first fixation at the sculpture increased medio-lateral stability (in terms of spectral power of body sway. Eye movement exploration in the depth of the sculpture increased antero-posterior stability (in terms of spectral power and cancelling time of body sway at the expense of medio-lateral stability (in terms of cancelling time. Moreover, a medio-lateral instability associated with eye movement exploration before the promenade (in terms of body sway sensu stricto was cancelled after the promenade. Finally, the overall medio-lateral stability (in terms of spectral power increased after the promenade.Fourteen additional visitors were asked to sit in a dark room and adjust a luminous line to what they considered to be the earth-vertical axis. The promenade executed within the sculpted environment afforded by Serra’s monumental statuary works resulted in significantly improved performances on the subjective visual vertical test.We attribute these effects to the sculpted environment provided by the exhibition which may have acted as a kind of physiologic training ground thereby improving the visitors’ overall sense of visual perspective, equilibrium and gravity.

GammaSem Proceedings - A Nordic seminar for users of gamma spectrometry

International Nuclear Information System (INIS)

Nunez, P.; Klemola, S.; Nielsen, Sven P.; Palsson, S.E.; Israelson, C.

2010-03-01

The project GammaSem was proposed to provide a forum for discussions and sharing of information on practical issues concerning gamma spectrometry and to establish a network of users of gamma spectrometry in the Nordic countries, thereby strengthening the collaboration and improving all participants' competence in practical gamma spectrometry. The seminars' focus was practical challenges met by the users themselves, rather than theoretical matters. Scientists and users of gamma spectrometry from all five Nordic countries were invited to the seminar, as well as scientist from the Baltic countries. A total of 75 people participated; representing 34 different universities, commercial companies, research institutes and also all Nordic authorities. During the seminar several key issues for follow-up were identified and working groups for addressing the identified problems were established. The working groups were: 1) Uncertainties and detections of limits 2) True summing coincidence 3) Monte Carlo simulations and efficiency transfer 4) Absorption (density corrections and geometries) 5) Mobile gamma spectrometry systems 6) Nuclear forensics (on special samples and special parts of the spectra). The identified topics will form the basis for the agenda of the next seminar in 2010. There, the different working groups will be invited to present their ideas/solutions to the relevant problems. (author)

GammaSem Proceedings - A Nordic seminar for users of gamma spectrometry

Energy Technology Data Exchange (ETDEWEB)

Nunez, P. (ed.) (Institute for Energy Technology (IFE) (Norway)); Klemola, S. (Radiation and Nuclear Safety Authority (STUK) (Finland)); Nielsen, Sven P. (Technical Univ. of Denmark, Risoe National Lab. for Sustainable Energy. Roskilde (Denmark)); Palsson, S.E. (Icelandic Radiation Safety Authority (IS)); Israelson, C. (National Institute of Radiation Protection (Denmark))

2010-03-15

The project GammaSem was proposed to provide a forum for discussions and sharing of information on practical issues concerning gamma spectrometry and to establish a network of users of gamma spectrometry in the Nordic countries, thereby strengthening the collaboration and improving all participants' competence in practical gamma spectrometry. The seminars' focus was practical challenges met by the users themselves, rather than theoretical matters. Scientists and users of gamma spectrometry from all five Nordic countries were invited to the seminar, as well as scientist from the Baltic countries. A total of 75 people participated; representing 34 different universities, commercial companies, research institutes and also all Nordic authorities. During the seminar several key issues for follow-up were identified and working groups for addressing the identified problems were established. The working groups were: 1) Uncertainties and detections of limits 2) True summing coincidence 3) Monte Carlo simulations and efficiency transfer 4) Absorption (density corrections and geometries) 5) Mobile gamma spectrometry systems 6) Nuclear forensics (on special samples and special parts of the spectra). The identified topics will form the basis for the agenda of the next seminar in 2010. There, the different working groups will be invited to present their ideas/solutions to the relevant problems. (author)

Implementation of suitable flow injection/sequential-sample separation/preconcentration schemes for determination of trace metal concentrations using detection by electrothermal atomic absorption spectrometry and inductively coupled plasma mass spectrometry

DEFF Research Database (Denmark)

Hansen, Elo Harald; Wang, Jianhua

2002-01-01

Various preconditioning procedures encomprising appropriate separation/preconcentration schemes in order to obtain optimal sensitivity and selectivity characteristics when using electrothermal atomic absorption spectrometry (ETAAS) and inductively coupled plasma mass spectrometry (ICPMS...

Performance of alpha spectrometry in the analysis of uranium isotopes in environmental and nuclear materials

International Nuclear Information System (INIS)

Carvalho, F.P.; Oliveira, J.M.

2009-01-01

The accuracy of alpha spectrometry in the determination of uranium isotopes at various concentrations levels and with various isotope ratios was tested in a round robin international intercomparison exercise. Results of isotope activity/mass and isotope mass ratios obtained by alpha spectrometry were accurate in a wide range of uranium masses and in isotopic ratios typical of depleted, natural, and low enriched uranium samples. Determinations by alpha spectrometry compared very satisfactorily in accuracy with those by mass spectrometry. For example, determination of U isotopes in natural uranium by alpha spectrometry agreed with mass spectrometry determinations at within ±1%. However, the 236 U isotope, particularly if present in activities much lower than 235 U, might not be determined accurately due to overlap in the alpha particle energies of these two uranium isotopes. (author)

Membrane introduction proton-transfer-reaction mass spectrometry

International Nuclear Information System (INIS)

Alexander, M.; Boscaini, E.; Maerk, T.; Lindinger, W.

2002-01-01

Proton-transfer-reaction mass spectrometry (PTR-MS) is a rapidly expanding field with multiple applications in ion physics, atmospheric chemistry, food chemistry, volatile organic compounds monitoring and biology. Initial studies that combine PTR-MS and membrane introduction mass spectrometry (MIMS) were researched and outlined. First using PTR-MS, certain fundamental physical properties of a poly-dimethylsiloxane (PDMS) membrane including solubilities and diffusion coefficients were measured. Second, it was shown how the chemical selectivity of the (PDMS) can be used to extend the capabilities of the PTR-MS instrument by eliminating certain isobaric interferences and excluding water from volatile organic compounds (VOCs). Experiments with mixtures of several VOCs (toluene, benzene, acetone, propanal, methanol) are presented. (nevyjel)

Hydrogen Exchange Mass Spectrometry

Science.gov (United States)

Mayne, Leland

2018-01-01

Hydrogen exchange (HX) methods can reveal much about the structure, energetics, and dynamics of proteins. The addition of mass spectrometry (MS) to an earlier fragmentation-separation HX analysis now extends HX studies to larger proteins at high structural resolution and can provide information not available before. This chapter discusses experimental aspects of HX labeling, especially with respect to the use of MS and the analysis of MS data. PMID:26791986

Mass spectrometry of large molecules

International Nuclear Information System (INIS)

Facchetti, S.

1985-01-01

The lectures in this volume were given at a course on mass spectrometry of large molecules, organized within the framework of the Training and Education programme of the Joint Research Centre of the European Communities. Although first presented in 1983, most of the lectures have since been updated by their authors. (orig.)

Neutron fluence spectrometry using disk activation

International Nuclear Information System (INIS)

Loevestam, Goeran; Hult, Mikael; Fessler, Andreas; Gasparro, Joel; Kockerols, Pierre; Okkinga, Klaas; Tagziria, Hamid; Vanhavere, Filip; Wieslander, J.S. Elisabeth

2009-01-01

A simple and robust detector for spectrometry of environmental neutrons has been developed. The technique is based on neutron activation of a series of different metal disks followed by low-level gamma-ray spectrometry of the activated disks and subsequent neutron spectrum unfolding. The technique is similar to foil activation but here the applied neutron fluence rates are much lower than usually in the case of foil activation. The detector has been tested in quasi mono-energetic neutron fields with fluence rates in the order of 1000-10000 cm -2 s -1 , where the obtained spectra showed good agreement with spectra measured using a Bonner sphere spectrometer. The detector has also been tested using an AmBe source and at a neutron fluence rate of about 40 cm -2 s -1 , again, a good agreement with the assumed spectrum was achieved

Subcellular analysis by laser ablation electrospray ionization mass spectrometry

Science.gov (United States)

Vertes, Akos; Stolee, Jessica A; Shrestha, Bindesh

2014-12-02

In various embodiments, a method of laser ablation electrospray ionization mass spectrometry (LAESI-MS) may generally comprise micro-dissecting a cell comprising at least one of a cell wall and a cell membrane to expose at least one subcellular component therein, ablating the at least one subcellular component by an infrared laser pulse to form an ablation plume, intercepting the ablation plume by an electrospray plume to form ions, and detecting the ions by mass spectrometry.

An experimental 'Life' for an experimental life: Richard Waller's biography of Robert Hooke (1705).

Science.gov (United States)

Moxham, Noah

2016-03-01

Richard Waller's 'Life of Dr Robert Hooke', prefixed to his edition of Hooke's Posthumous Works (1705), is an important source for the life of one of the most eminent members of the early Royal Society. It also has the distinction of being one of the earliest biographies of a man of science to be published in English. I argue that it is in fact the first biography to embrace the subject's natural-philosophical work as the centre of his life, and I investigate Waller's reasons for adopting this strategy and his struggle with the problem of how to represent an early experimental philosopher in print. I suggest that Waller eschews the 'Christian philosopher' tradition of contemporary biography - partly because of the unusually diverse and fragmentary nature of Hooke's intellectual output - and draws instead upon the structure of the Royal Society's archive as a means of organizing and understanding Hooke's life. The most quoted phrase from Waller's biography is that Hooke became 'to a crime close and reserved' in later life; this essay argues that Waller's biographical sketch was fashioned in order to undo the effects of that reserve. In modelling his approach very closely on the structure of the society's records he was principally concerned with making Hooke's work and biography accessible, intelligible and useful to the fellowship in a context familiar to them, a context which had provided the institutional framework for most of Hooke's adult life. I argue that Waller's 'Life' was also intended to make the largest claims for Hooke's intellectual standing that the author dared in the context of the enmity between Hooke and Isaac Newton once the latter became president of the Royal Society. However, I also adduce fresh manuscript evidence that Waller actually compiled, but did not publish, a defence of Hooke's claim to have discovered the inverse square law of gravity, allowing us to glimpse a much more assertive biography of Hooke than the published version.

Elucidating rhizosphere processes by mass spectrometry – A review

International Nuclear Information System (INIS)

Rugova, Ariana; Puschenreiter, Markus; Koellensperger, Gunda; Hann, Stephan

2017-01-01

The presented review discusses state-of-the-art mass spectrometric methods, which have been developed and applied for investigation of chemical processes in the soil-root interface, the so-called rhizosphere. Rhizosphere soil's physical and chemical characteristics are to a great extent influenced by a complex mixture of compounds released from plant roots, i.e. root exudates, which have a high impact on nutrient and trace element dynamics in the soil-root interface as well as on microbial activities or soil physico-chemical characteristics. Chemical characterization as well as accurate quantification of the compounds present in the rhizosphere is a major prerequisite for a better understanding of rhizosphere processes and requires the development and application of advanced sampling procedures in combination with highly selective and sensitive analytical techniques. During the last years, targeted and non-targeted mass spectrometry-based methods have emerged and their combination with specific separation methods for various elements and compounds of a wide polarity range have been successfully applied in several studies. With this review we critically discuss the work that has been conducted within the last decade in the context of rhizosphere research and elemental or molecular mass spectrometry emphasizing different separation techniques as GC, LC and CE. Moreover, selected applications such as metal detoxification or nutrient acquisition will be discussed regarding the mass spectrometric techniques applied in studies of root exudates in plant-bacteria interactions. Additionally, a more recent isotope probing technique as novel mass spectrometry based application is highlighted. - Highlights: • State-of-the-art mass spectrometry methods developed and applied in rhizosphere research are reviewed. • Elemental and molecular mass spectrometry emphasizing different separation techniques (GC, LC or CE) are discussed. • Case studies on metal detoxification and

Elucidating rhizosphere processes by mass spectrometry – A review

Energy Technology Data Exchange (ETDEWEB)

Rugova, Ariana [Division of Analytical Chemistry, Department of Chemistry, University of Natural Resources and Life Sciences-BOKU, Vienna (Austria); Puschenreiter, Markus [Department of Forest and Soil Sciences, Rhizosphere Ecology and Biogeochemistry Group, University of Natural Resources and Life Sciences-BOKU, Vienna (Austria); Koellensperger, Gunda [Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna (Austria); Hann, Stephan, E-mail: stephan.hann@boku.ac.at [Division of Analytical Chemistry, Department of Chemistry, University of Natural Resources and Life Sciences-BOKU, Vienna (Austria)

2017-03-01

The presented review discusses state-of-the-art mass spectrometric methods, which have been developed and applied for investigation of chemical processes in the soil-root interface, the so-called rhizosphere. Rhizosphere soil's physical and chemical characteristics are to a great extent influenced by a complex mixture of compounds released from plant roots, i.e. root exudates, which have a high impact on nutrient and trace element dynamics in the soil-root interface as well as on microbial activities or soil physico-chemical characteristics. Chemical characterization as well as accurate quantification of the compounds present in the rhizosphere is a major prerequisite for a better understanding of rhizosphere processes and requires the development and application of advanced sampling procedures in combination with highly selective and sensitive analytical techniques. During the last years, targeted and non-targeted mass spectrometry-based methods have emerged and their combination with specific separation methods for various elements and compounds of a wide polarity range have been successfully applied in several studies. With this review we critically discuss the work that has been conducted within the last decade in the context of rhizosphere research and elemental or molecular mass spectrometry emphasizing different separation techniques as GC, LC and CE. Moreover, selected applications such as metal detoxification or nutrient acquisition will be discussed regarding the mass spectrometric techniques applied in studies of root exudates in plant-bacteria interactions. Additionally, a more recent isotope probing technique as novel mass spectrometry based application is highlighted. - Highlights: • State-of-the-art mass spectrometry methods developed and applied in rhizosphere research are reviewed. • Elemental and molecular mass spectrometry emphasizing different separation techniques (GC, LC or CE) are discussed. • Case studies on metal detoxification

Comparison of 15N analysis by optical emission spectrometry and mass spectrometry for clinical studies during total parenteral nutrition

International Nuclear Information System (INIS)

Ragon, A.; Reynier, J.P.; Guiraud, G.

1985-01-01

During total and stable parenteral nutrition, a branched chain amino acid enriched solution containing [ 15 N]leucine was infused into a patient to determine the fate of the nitrogen administered through this formulation. Measurements of 15 N isotopic enrichments were performed on the same biological samples (urinary urea, total plasma proteins and albumin) by optical emission spectrometry (OES) and mass spectrometry (MS) to determine if OES with its specific advantages (cost, handling maintenance) constituted even with low enrichments a useful alternative technique to MS considered as the reference method. The results show that OES constituted a very useful analytical technique to obtain reliable information in clinical metabolic studies when low 15 N enrichments must be determined. (Auth.)

Mass Spectrometry Market: Value chain and stakeholder analysis up to 2024

OpenAIRE

Smita Deshmukh

2016-01-01

Transparency Market Research Reports incorporated a definite business overview and investigation inclines on "Mass Spectrometry Market". This report likewise incorporates more illumination about fundamental review of the business including definitions, requisitions and worldwide business sector industry structure. Read Full Report: http://www.transparencymarketresearch.com/mass-spectrometry-market.html

Peculiarities of the modern neutron spectrometry

Indian Academy of Sciences (India)

Abstract. Neutron spectrometry provides many branches of science and technology with the .... of this isotope is close to constant for some intervals of atomic mass. For real ... There are nice reviews on these processes [8] and [9]. The data of ...

Impact of comprehensive two-dimensional gas chromatography with mass spectrometry on food analysis.

Science.gov (United States)

Tranchida, Peter Q; Purcaro, Giorgia; Maimone, Mariarosa; Mondello, Luigi

2016-01-01

Comprehensive two-dimensional gas chromatography with mass spectrometry has been on the separation-science scene for about 15 years. This three-dimensional method has made a great positive impact on various fields of research, and among these that related to food analysis is certainly at the forefront. The present critical review is based on the use of comprehensive two-dimensional gas chromatography with mass spectrometry in the untargeted (general qualitative profiling and fingerprinting) and targeted analysis of food volatiles; attention is focused not only on its potential in such applications, but also on how recent advances in comprehensive two-dimensional gas chromatography with mass spectrometry will potentially be important for food analysis. Additionally, emphasis is devoted to the many instances in which straightforward gas chromatography with mass spectrometry is a sufficiently-powerful analytical tool. Finally, possible future scenarios in the comprehensive two-dimensional gas chromatography with mass spectrometry food analysis field are discussed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Helium-3 mass spectrometry for low-level tritium analysis of environmental samples

International Nuclear Information System (INIS)

Surano, K.A.; Hudson, G.B.; Failor, R.A.; Sims, J.M.; Holland, R.C.; MacLean, S.C.; Garrison, J.C.

1991-04-01

Helium-3 ( 3 He) mass spectrometry for the analysis of low-level tritium ( 3 H) concentrations in environmental sample matrices was compared with conventional low-level β-decay counting methods. The mass-spectrometry method compared favorably, equaling or surpassing conventional decay-counting methods with respect to most criteria. Additional research and method refinements may make 3 He mass spectrometry the method of choice for routine, low-level to very-low-level 3 H measurements in a wide variety of environmental samples in the future

Nanostructure-initiator mass spectrometry biometrics

Science.gov (United States)

Leclerc, Marion; Bowen, Benjamin; Northen, Trent

2015-09-08

Several embodiments described herein are drawn to methods of identifying an analyte on a subject's skin, methods of generating a fingerprint, methods of determining a physiological change in a subject, methods of diagnosing health status of a subject, and assay systems for detecting an analyte and generating a fingerprint, by nanostructure-initiator mass spectrometry (NIMS).

A Review of the Emerging Field of Underwater Mass Spectrometry

Directory of Open Access Journals (Sweden)

Emily Chua

2016-11-01

Full Text Available Mass spectrometers are versatile sensor systems, owing to their high sensitivity and ability to simultaneously measure multiple chemical species. Over the last two decades, traditional laboratory-based membrane inlet mass spectrometers have been adapted for underwater use. Underwater mass spectrometry has drastically improved our capability to monitor a broad suite of gaseous compounds (e.g., dissolved atmospheric gases, light hydrocarbons, and volatile organic compounds in the aquatic environment. Here we provide an overview of the progress made in the field of underwater mass spectrometry since its inception in the 1990s to the present. In particular, we discuss the approaches undertaken by various research groups in developing in situ mass spectrometers. We also provide examples to illustrate how underwater mass spectrometers have been used in the field. Finally, we present future trends in the field of in situ mass spectrometry. Most of these efforts are aimed at improving the quality and spatial and temporal scales of chemical measurements in the ocean. By providing up-to-date information on underwater mass spectrometry, this review offers guidance for researchers interested in adapting this technology as well as goals for future progress in the field.

Mass Spectrometry-Based Proteomics for Pre-Eclampsia and Preterm Birth

Directory of Open Access Journals (Sweden)

Kai P. Law

2015-05-01

Full Text Available Pregnancy-related complications such as pre-eclampsia and preterm birth now represent a notable burden of adverse health. Pre-eclampsia is a hypertensive disorder unique to pregnancy. It is an important cause of maternal death worldwide and a leading cause of fetal growth restriction and iatrogenic prematurity. Fifteen million infants are born preterm each year globally, but more than one million of those do not survive their first month of life. Currently there are no predictive tests available for diagnosis of these pregnancy-related complications and the biological mechanisms of the diseases have not been fully elucidated. Mass spectrometry-based proteomics have all the necessary attributes to provide the needed breakthrough in understanding the pathophysiology of complex human diseases thorough the discovery of biomarkers. The mass spectrometry methodologies employed in the studies for pregnancy-related complications are evaluated in this article. Top-down proteomic and peptidomic profiling by laser mass spectrometry, liquid chromatography or capillary electrophoresis coupled to mass spectrometry, and bottom-up quantitative proteomics and targeted proteomics by liquid chromatography mass spectrometry have been applied to elucidate protein biomarkers and biological mechanism of pregnancy-related complications. The proteomes of serum, urine, amniotic fluid, cervical-vaginal fluid, placental tissue, and cytotrophoblastic cells have all been investigated. Numerous biomarkers or biomarker candidates that could distinguish complicated pregnancies from healthy controls have been proposed. Nevertheless, questions as to the clinically utility and the capacity to elucidate the pathogenesis of the pre-eclampsia and preterm birth remain to be answered.

Mass Spectrometry-Based Proteomics for Pre-Eclampsia and Preterm Birth

Science.gov (United States)

Law, Kai P.; Han, Ting-Li; Tong, Chao; Baker, Philip N.

2015-01-01

Pregnancy-related complications such as pre-eclampsia and preterm birth now represent a notable burden of adverse health. Pre-eclampsia is a hypertensive disorder unique to pregnancy. It is an important cause of maternal death worldwide and a leading cause of fetal growth restriction and iatrogenic prematurity. Fifteen million infants are born preterm each year globally, but more than one million of those do not survive their first month of life. Currently there are no predictive tests available for diagnosis of these pregnancy-related complications and the biological mechanisms of the diseases have not been fully elucidated. Mass spectrometry-based proteomics have all the necessary attributes to provide the needed breakthrough in understanding the pathophysiology of complex human diseases thorough the discovery of biomarkers. The mass spectrometry methodologies employed in the studies for pregnancy-related complications are evaluated in this article. Top-down proteomic and peptidomic profiling by laser mass spectrometry, liquid chromatography or capillary electrophoresis coupled to mass spectrometry, and bottom-up quantitative proteomics and targeted proteomics by liquid chromatography mass spectrometry have been applied to elucidate protein biomarkers and biological mechanism of pregnancy-related complications. The proteomes of serum, urine, amniotic fluid, cervical-vaginal fluid, placental tissue, and cytotrophoblastic cells have all been investigated. Numerous biomarkers or biomarker candidates that could distinguish complicated pregnancies from healthy controls have been proposed. Nevertheless, questions as to the clinically utility and the capacity to elucidate the pathogenesis of the pre-eclampsia and preterm birth remain to be answered. PMID:26006232

Determination of 5-fluorouracil in plasma with HPLC-tandem mass spectrometry

NARCIS (Netherlands)

van Kuilenburg, A. B. P.; van Lenthe, H.; Maring, J. G.; van Gennip, A. H.

2006-01-01

In this article, we describe a fast and specific method to measure 5FU with HPLC tandem-mass spectrometry. Reversed-phase HPLC was combined with electrospray ionization tandem mass spectrometry and detection was performed by multiple-reaction monitoring. Stable-isotope-labeled 5FU (1,3-15N2-5FU) was

Compilation of monographs on α-, β-, γ- and X-ray spectrometry

International Nuclear Information System (INIS)

Debertin, K.

1977-11-01

The working group 'α-, β-, γ-Ray Spectrometry' of the International Committee for Radionuclide Metrology (ICRM) compiled about 35 monographs on α-, β-, γ- and X-ray spectrometry which were published in the years 1970 to 1976. Support was obtained by the Zentralstelle fuer Atomkernenergie-Dokumentation (ZAED) in Karlsruhe. (orig.) [de

Quantitative correlations between collision induced dissociation mass spectrometry coupled with electrospray ionization or atmospheric pressure chemical ionization mass spectrometry - Experiment and theory

Science.gov (United States)

Ivanova, Bojidarka; Spiteller, Michael

2018-04-01

The problematic that we consider in this paper treats the quantitative correlation model equations between experimental kinetic and thermodynamic parameters of coupled electrospray ionization (ESI) mass spectrometry (MS) or atmospheric pressure chemical ionization (APCI) mass spectrometry with collision induced dissociation mass spectrometry, accounting for the fact that the physical phenomena and mechanisms of ESI- and APCI-ion formation are completely different. There are described forty two fragment reactions of three analytes under independent ESI- and APCI-measurements. The developed new quantitative models allow us to study correlatively the reaction kinetics and thermodynamics using the methods of mass spectrometry, which complementary application with the methods of the quantum chemistry provide 3D structural information of the analytes. Both static and dynamic quantum chemical computations are carried out. The object of analyses are [2,3-dimethyl-4-(4-methyl-benzoyl)-2,3-di-p-tolyl-cyclobutyl]-p-tolyl-methanone (1) and the polycyclic aromatic hydrocarbons derivatives of dibenzoperylen (2) and tetrabenzo [a,c,fg,op]naphthacene (3), respectively. As far as (1) is known to be a product of [2π+2π] cycloaddition reactions of chalcone (1,3-di-p-tolyl-propenone), however producing cyclic derivatives with different stereo selectivity, so that the study provide crucial data about the capability of mass spectrometry to provide determine the stereo selectivity of the analytes. This work also first provides quantitative treatment of the relations '3D molecular/electronic structures'-'quantum chemical diffusion coefficient'-'mass spectrometric diffusion coefficient', thus extending the capability of the mass spectrometry for determination of the exact 3D structure of the analytes using independent measurements and computations of the diffusion coefficients. The determination of the experimental diffusion parameters is carried out within the 'current monitoring method

Automated, parallel mass spectrometry imaging and structural identification of lipids

DEFF Research Database (Denmark)

Ellis, Shane R.; Paine, Martin R.L.; Eijkel, Gert B.

2018-01-01

We report a method that enables automated data-dependent acquisition of lipid tandem mass spectrometry data in parallel with a high-resolution mass spectrometry imaging experiment. The method does not increase the total image acquisition time and is combined with automatic structural assignments....... This lipidome-per-pixel approach automatically identified and validated 104 unique molecular lipids and their spatial locations from rat cerebellar tissue....

Mass spectrometry in oceanography

International Nuclear Information System (INIS)

Aggarwal, Suresh K.

2000-01-01

Mass spectrometry plays an important role in oceanography for various applications. Different types of inorganic as well as organic mass spectrometric techniques are being exploited world-wide to understand the different aspects of marine science, for palaeogeography, palaeoclimatology and palaeoecology, for isotopic composition and concentrations of different elements as well as for speciation studies. The present paper reviews some of the applications of atomic mass spectrometric techniques in the area of oceanography

Towards airborne nanoparticle mass spectrometry with nanomechanical string resonators

DEFF Research Database (Denmark)

Schmid, Silvan; Kurek, Maksymilian; Boisen, Anja

2013-01-01

airborne nanoparticle sensors. Recently, nanomechanical mass spectrometry was established. One of the biggest challenges of nanomechanical sensors is the low efficiency of diffusion-based sampling. We developed an inertial-based sampling method that enables the efficient sampling of airborne nanoparticles...... mode. Mass spectrometry of airborne nanoparticles requires the simultaneous operation in the first and second mode, which can be implemented in the transduction scheme of the resonator. The presented results lay the cornerstone for the realization of a portable airborne nanoparticle mass spectrometer....

Quantitating subcellular metabolism with multi-isotope imaging mass spectrometry

OpenAIRE

Steinhauser, Matthew L.; Bailey, Andrew; Senyo, Samuel E.; Guillermier, Christelle; Perlstein, Todd S.; Gould, Alex P.; Lee, Richard T.; Lechene, Claude P.

2012-01-01

Mass spectrometry with stable isotope labels has been seminal in discovering the dynamic state of living matter 1,2 but is limited to bulk tissues or cells. We developed multi-isotope imaging mass spectrometry (MIMS) that allowed us to view and measure stable isotope incorporation with sub-micron resolution 3,4 . Here we apply MIMS to diverse organisms, including Drosophila, mice, and humans. We test the “immortal strand hypothesis,” which predicts that during asymmetric stem cell division ch...

Analysis of chirality by femtosecond laser ionization mass spectrometry.

Science.gov (United States)

Horsch, Philipp; Urbasch, Gunter; Weitzel, Karl-Michael

2012-09-01

Recent progress in the field of chirality analysis employing laser ionization mass spectrometry is reviewed. Emphasis is given to femtosecond (fs) laser ionization work from the author's group. We begin by reviewing fundamental aspects of determining circular dichroism (CD) in fs-laser ionization mass spectrometry (fs-LIMS) discussing an example from the literature (resonant fs-LIMS of 3-methylcyclopentanone). Second, we present new data indicating CD in non-resonant fs-LIMS of propylene oxide. Copyright © 2012 Wiley Periodicals, Inc., A Wiley Company.

Atomization mechanisms for barium in furnace atomic absorption spectrometry

International Nuclear Information System (INIS)

Styris, D.L.

1984-01-01

Atomic absorption spectrometry and mass spectrometry are used simultaneously in order to elucidate atomization mechanisms of barium dichloride in pyrolytic graphite, vitreous carbon, and tantalum furnaces. Gas-phase barium dicarbide is observed to appear concurrently with the free barium. Barium oxide and barium dihydroxide precursors appear with the chlorides. Surface reactions involving species that are absorbed on the various furnaces are postulated to explain the appearances of the species that are observed in the gas phase. 49 references, 4 figures, 1 table

ISMAS international discussion meet on elemental mass spectrometry in health and environmental sciences

International Nuclear Information System (INIS)

Aggarwal, S.K.; Jaison, P.G.; Telmore, V.M.

2011-04-01

Mass spectrometry is an indispensable analytical tool associated with almost all branches of science including biology, chemistry, earth sciences, nuclear science, physics, etc. The technique holds tremendous potential owing to its high sensitivity, selectivity and its ability to measure small changes in the isotopic abundances of different elements. Innovations in mass spectrometry instrumentation are further widening the scope by making it possible to handle very large bio-molecules and polymers. New techniques for mass analysis, novel designs for ionization and developments in electronic accessories have contributed to elevate mass spectrometry to a position of prime importance in research. Development in mass spectrometry has revolutionized the study of micro-nutrient metabolism, of biologically active compounds and for drug discovery in pharmaceutical research. Elemental mass spectrometry is making major contributions to food toxicology, food forensics, and study of metabolism of nutrient minerals including Fe, Zn, Ca, Cu and Se. The area of speciation analysis using hyphenated techniques as well as electro-spray ionization have undergone a phenomenal evolution and development in the recent past. Impressive progress in mass spectrometry towards lower detection limits, higher resolution and molecule-specific detection at trace levels in complex matrices allows new frontiers to be crossed. Papers relevant to INIS are indexed separately

Gamma and X 93 spectrometry

International Nuclear Information System (INIS)

1994-05-01

The Meetings of Gamma and X 93 Spectrometry were held on 12-14 October 1993. The symposium was organized into six sessions: Instrumentation development, Nuclear matter measurement, Method and calibration, Medical applications, Environment survey (radioactive traces measurement), other applications (spent fuels analysis, various techniques). Separate abstracts were prepared for all the papers in this volume. (TEC)

High-Performance Liquid Chromatography-Mass Spectrometry.

Science.gov (United States)

Vestal, Marvin L.

1984-01-01

Reviews techniques for online coupling of high-performance liquid chromatography with mass spectrometry, emphasizing those suitable for application to nonvolatile samples. Also summarizes the present status, strengths, and weaknesses of various techniques and discusses potential applications of recently developed techniques for combined liquid…

Ion Mobility Spectrometry-Mass Spectrometry Coupled with Gas-Phase Hydrogen/Deuterium Exchange for Metabolomics Analyses

Science.gov (United States)

Maleki, Hossein; Karanji, Ahmad K.; Majuta, Sandra; Maurer, Megan M.; Valentine, Stephen J.

2018-02-01

Ion mobility spectrometry-mass spectrometry (IMS-MS) in combination with gas-phase hydrogen/deuterium exchange (HDX) and collision-induced dissociation (CID) is evaluated as an analytical method for small-molecule standard and mixture characterization. Experiments show that compound ions exhibit unique HDX reactivities that can be used to distinguish different species. Additionally, it is shown that gas-phase HDX kinetics can be exploited to provide even further distinguishing capabilities by using different partial pressures of reagent gas. The relative HDX reactivity of a wide variety of molecules is discussed in light of the various molecular structures. Additionally, hydrogen accessibility scoring (HAS) and HDX kinetics modeling of candidate ( in silico) ion structures is utilized to estimate the relative ion conformer populations giving rise to specific HDX behavior. These data interpretation methods are discussed with a focus on developing predictive tools for HDX behavior. Finally, an example is provided in which ion mobility information is supplemented with HDX reactivity data to aid identification efforts of compounds in a metabolite extract.

Proceedings of twelfth ISMAS symposium cum workshop on mass spectrometry

International Nuclear Information System (INIS)

Alamelu, D.; Jaison, P.G.; Aggarwal, S.K.

2007-03-01

Mass Spectrometry is an important analytical tool and has encompassed almost all branches of science and technology including Agricultural, biology, Chemistry, Earth sciences, environment, Forensic Science, Medical Sciences, Hydrology, Nuclear Technology, Oceanography, Physics etc. Recent advancements in the instrumentation of Mass Spectrometry have further strengthened its role for various applications. It is indeed a matter of great pleasure to present this special Issue of ISMAS Bulletin which is brought out on the occasion of the 12th ISMAS Symposium cum Workshop on Mass spectrometry (12th ISMAS-WS 2007) being held at Cidade-de-Goa, Dona Paula, Goa from March 25 to 30, 2007 in association with National Institute of Oceanography, Goa. This Symposium cum Workshop is co-sponsored by Scientific Departments of Government of India. Papers relevant to INIS are indexed separately

Accelerator mass spectrometry: state of the art

Energy Technology Data Exchange (ETDEWEB)

Tuniz, C. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

1996-12-31

Accelerator Mass Spectrometry (AMS) is the analytical technique of choice for the detection of long-lived radionuclides which cannot be practically analysed with decay counting or conventional mass spectrometry. The main use of AMS has been in the analysis of radiocarbon and other cosmogenic radionuclides for archaeological, geological and environmental applications. In addition, AMS has been recently applied in biomedicine to study exposure of human tissues to chemicals and biomolecules at attomole levels. There is also a world-wide effort to analyse rare nuclides of heavier masses, such as long-lived actinides, with important applications in safeguards and nuclear waste disposal. The use of AMS is limited by the expensive accelerator technology required and there are several attempts to develop smaller and cheaper AMS spectrometers. 5 refs.

Accelerator mass spectrometry: state of the art

Energy Technology Data Exchange (ETDEWEB)

Tuniz, C [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

1997-12-31

Accelerator Mass Spectrometry (AMS) is the analytical technique of choice for the detection of long-lived radionuclides which cannot be practically analysed with decay counting or conventional mass spectrometry. The main use of AMS has been in the analysis of radiocarbon and other cosmogenic radionuclides for archaeological, geological and environmental applications. In addition, AMS has been recently applied in biomedicine to study exposure of human tissues to chemicals and biomolecules at attomole levels. There is also a world-wide effort to analyse rare nuclides of heavier masses, such as long-lived actinides, with important applications in safeguards and nuclear waste disposal. The use of AMS is limited by the expensive accelerator technology required and there are several attempts to develop smaller and cheaper AMS spectrometers. 5 refs.

Time-of-flight scattering and recoiling spectrometry

International Nuclear Information System (INIS)

Rabalais, J.W.

1991-01-01

Ion scattering and recoiling spectrometry consists of directing a collimated beam of monoenergetic ions towards a surface and measuring the flux of scattered and recoiled particles from this surface. When the neutral plus ion flux is velocity selected by measuring the flight times from the sample to the detector, the technique is called time-of-flight scattering and recoiling spectrometry (TOF-SARS). TOF-SARS is capable of (1) surface elemental analysis by applying classical mechanics to the velocities of the particles, (2) surface structural analysis by monitoring the angular anisotropies in the particle flux, and (3) ion-surface electron exchange probabilities by analysis of the ion/neutral fractions in the particle flux. Examples of these three areas are presented herein

Neutron fluence spectrometry using disk activation

Energy Technology Data Exchange (ETDEWEB)

Loevestam, Goeran [EC-JRC-Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, B-2440 Geel (Belgium)], E-mail: goeran.loevestam@ec.europa.eu; Hult, Mikael; Fessler, Andreas; Gasparro, Joel; Kockerols, Pierre; Okkinga, Klaas [EC-JRC-Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, B-2440 Geel (Belgium); Tagziria, Hamid [EC-JRC-Institute for the Protection and the Security of the Citizen (IPSC), Via E. Fermi 1, I-21020 Ispra (Vatican City State, Holy See,) (Italy); Vanhavere, Filip [SCK-CEN, Boeretang, 2400 Mol (Belgium); Wieslander, J.S. Elisabeth [EC-JRC-Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, B-2440 Geel (Belgium); Department of Physics, P.O. Box 35 (YFL), FIN-40014, University of Jyvaeskylae (Finland)

2009-01-15

A simple and robust detector for spectrometry of environmental neutrons has been developed. The technique is based on neutron activation of a series of different metal disks followed by low-level gamma-ray spectrometry of the activated disks and subsequent neutron spectrum unfolding. The technique is similar to foil activation but here the applied neutron fluence rates are much lower than usually in the case of foil activation. The detector has been tested in quasi mono-energetic neutron fields with fluence rates in the order of 1000-10000 cm{sup -2} s{sup -1}, where the obtained spectra showed good agreement with spectra measured using a Bonner sphere spectrometer. The detector has also been tested using an AmBe source and at a neutron fluence rate of about 40 cm{sup -2} s{sup -1}, again, a good agreement with the assumed spectrum was achieved.

Mass Spectrometry Imaging of Drugs of Abuse in Hair.

Science.gov (United States)

Flinders, Bryn; Cuypers, Eva; Porta, Tiffany; Varesio, Emmanuel; Hopfgartner, Gérard; Heeren, Ron M A

2017-01-01

Hair testing is a powerful tool routinely used for the detection of drugs of abuse. The analysis of hair is highly advantageous as it can provide prolonged drug detectability versus that in biological fluids and chronological information about drug intake based on the average growth of hair. However, current methodology requires large amounts of hair samples and involves complex time-consuming sample preparation followed by gas or liquid chromatography coupled with mass spectrometry. Mass spectrometry imaging is increasingly being used for the analysis of single hair samples, as it provides more accurate and visual chronological information in single hair samples.Here, two methods for the preparation of single hair samples for mass spectrometry imaging are presented.The first uses an in-house built cutting apparatus to prepare longitudinal sections, the second is a method for embedding and cryo-sectioning hair samples in order to prepare cross-sections all along the hair sample.

Further development of IDGS: Isotope dilution gamma-ray spectrometry

International Nuclear Information System (INIS)

Li, T.K.; Parker, J.L.; Kuno, Y.; Sato, S.; Kamata, M.; Akiyama, T.

1991-01-01

The isotope dilution gamma-ray spectrometry (IDGS) technique for determining the plutonium concentration and isotopic composition of highly radioactive spent-fuel dissolver solutions has been further developed. Both the sample preparation and the analysis have been improved. The plutonium isotopic analysis is based on high-resolution, low-energy gamma-ray spectrometry. The plutonium concentration in the dissolver solutions then is calculated from the measured isotopic differences among the spike, the dissolver solution, and the spiked dissolver solution. Plutonium concentrations and isotopic compositions of dissolver solutions analyzed from this study agree well with those obtained by traditional isotope dilution mass spectrometry (IDMS) and are consistent with the first IDGS experimental result. With the current detector efficiency, sample size, and a 100-min count time, the estimated precision is ∼0.5% for 239 Pu and 240 Pu isotopic analyses and ∼1% for the plutonium concentration analysis. 5 refs., 2 figs., 7 tabs

Hydrogen/deuterium exchange in mass spectrometry.

Science.gov (United States)

Kostyukevich, Yury; Acter, Thamina; Zherebker, Alexander; Ahmed, Arif; Kim, Sunghwan; Nikolaev, Eugene

2018-03-30

The isotopic exchange approach is in use since the first observation of such reactions in 1933 by Lewis. This approach allows the investigation of the pathways of chemical and biochemical reactions, determination of structure, composition, and conformation of molecules. Mass spectrometry has now become one of the most important analytical tools for the monitoring of the isotopic exchange reactions. Investigation of conformational dynamics of proteins, quantitative measurements, obtaining chemical, and structural information about individual compounds of the complex natural mixtures are mainly based on the use of isotope exchange in combination with high resolution mass spectrometry. The most important reaction is the Hydrogen/Deuterium exchange, which is mainly performed in the solution. Recently we have developed the approach allowing performing of the Hydrogen/Deuterium reaction on-line directly in the ionization source under atmospheric pressure. Such approach simplifies the sample preparation and can accelerate the exchange reaction so that certain hydrogens that are considered as non-labile will also participate in the exchange. The use of in-ionization source H/D exchange in modern mass spectrometry for structural elucidation of molecules serves as the basic theme in this review. We will focus on the mechanisms of the isotopic exchange reactions and on the application of in-ESI, in-APCI, and in-APPI source Hydrogen/Deuterium exchange for the investigation of petroleum, natural organic matter, oligosaccharides, and proteins including protein-protein complexes. The simple scenario for adaptation of H/D exchange reactions into mass spectrometric method is also highlighted along with a couple of examples collected from previous studies. © 2018 Wiley Periodicals, Inc.

En torno al arte europeo de la segunda mitad del siglo XIX. Aspectos de las relaciones forma–contenido o forma–función en la obra de Lawrence Alma–Tadema, Gottfried Semper y Richard Wagner

OpenAIRE

Moreno Dopazo, Ángel

2011-01-01

El trabajo se plantea como una reflexión sobre la dificultad actual para apreciar los valores, a menudo denostados, de los ya supuestamente lejanos arte y cultura del siglo XIX. De aquel rico mundo de referentes y asociaciones se destacan aquí las figuras del pintor realista Alma-Tadema, los arquitectos del Ring de Viena, con Semper como singular protagonista, y el músico Richard Wagner. Junto al análisis del complejo universo pictórico del artista holandés afincado en Inglaterra se presenta ...

GammaSem Proceedings. A Nordic seminar for users of gamma spectrometry

Energy Technology Data Exchange (ETDEWEB)

Straalberg, E. (ed.) (Institute for Energy Technolgy (Norway)); Berg, K. (National Institute of Radiation Protection (Denmark)); Dowdall, M. (Norwegian Radiation Protection Authority (Norway)) (and others)

2010-11-15

The project GammaSem was proposed to the NKS in 2008. The aim of the project was to arrange two seminars for users of gamma spectrometry, in 2009 and 2010. The seminars were meant to provide a forum for discussions and sharing of information on practical issues concerning gamma spectrometry and initiate a network of gamma spectrometry users in the Nordic countries. Such a Nordic network should strengthen the collaboration between laboratories and improve all participants' competence in practical gamma spectrometry. Both seminars' focus was practical challenges met by the users themselves, rather than theoretical matters. Scientists and users of gamma spectrometry from all five Nordic countries were invited to the seminar, as well as scientist from the Baltic countries. A total of 65 people signed up for GammaSem 2010; representing 30 different universities, commercial companies, research institutes and authorities. The working group concept as presented at last year's GammaSem, has not worked out as intended. The reason for this is probably because most of the laboratories that signed up to join the working groups, signed up because they wanted to learn more about the different subjects. In combination with the fact that no funding was made available for the working groups, it was difficult to establish goals on what to achieve. None of the working groups applied for funding from the NKS (or elsewhere) to establish separate projects. There is a big need for more cooperation and for training within the field of gamma spectrometry. This fact has been proved through these two seminars, both by the many different topics that have been discussed, but also by the huge interest for participating in the suggested series of workshop. The GammaSem seminars have thus provided a much welcomed starting point for a broader Nordic collaboration. (Author)

GammaSem Proceedings. A Nordic seminar for users of gamma spectrometry

International Nuclear Information System (INIS)

Straelberg, E.; Berg, K.; Dowdall, M.

2010-11-01

The project GammaSem was proposed to the NKS in 2008. The aim of the project was to arrange two seminars for users of gamma spectrometry, in 2009 and 2010. The seminars were meant to provide a forum for discussions and sharing of information on practical issues concerning gamma spectrometry and initiate a network of gamma spectrometry users in the Nordic countries. Such a Nordic network should strengthen the collaboration between laboratories and improve all participants' competence in practical gamma spectrometry. Both seminars' focus was practical challenges met by the users themselves, rather than theoretical matters. Scientists and users of gamma spectrometry from all five Nordic countries were invited to the seminar, as well as scientist from the Baltic countries. A total of 65 people signed up for GammaSem 2010; representing 30 different universities, commercial companies, research institutes and authorities. The working group concept as presented at last year's GammaSem, has not worked out as intended. The reason for this is probably because most of the laboratories that signed up to join the working groups, signed up because they wanted to learn more about the different subjects. In combination with the fact that no funding was made available for the working groups, it was difficult to establish goals on what to achieve. None of the working groups applied for funding from the NKS (or elsewhere) to establish separate projects. There is a big need for more cooperation and for training within the field of gamma spectrometry. This fact has been proved through these two seminars, both by the many different topics that have been discussed, but also by the huge interest for participating in the suggested series of workshop. The GammaSem seminars have thus provided a much welcomed starting point for a broader Nordic collaboration. (Author)

Atmospheric pressure photo ionization hydrogen/deuterium exchange mass spectrometry--a method to differentiate isomers by mass spectrometry.

Science.gov (United States)

Ahmed, Arif; Kim, Sunghwan

2013-12-01

In this report, a method for in-source hydrogen/deuterium (H/D) exchange at atmospheric pressure is reported. The method was named atmospheric pressure photo ionization hydrogen/deuterium exchange mass spectrometry (APPI HDX MS). H/D exchange was performed by mixing samples dissolved in toluene with CH3OD solvent and analyzing the mixture using atmospheric pressure photo ionization mass spectrometry (APPI-MS). The APPI HDX spectra obtained with contact times between the analyte solution and methanol-OD (CH3OD) of atmospheric pressure. H/D exchange can be performed in any laboratory with a mass spectrometer and a commercial APPI source. Using this method, multiple H/D exchanges of aromatic hydrogen and/or H/D exchange of active hydrogen were observed. These results demonstrated that H/D exchange can be used to distinguish between isomers containing primary, secondary, and tertiary amines, as well as pyridine and pyrrole functional groups.

Comparison of 4 analytical techniques based on atomic spectrometry for the determination of total tin in canned foodstuffs

OpenAIRE

2011-01-01

Abstract Different techniques for the determination of total tin in beverage and canned food by atomic spectrometry were compared. The performance characteristics of Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Hydride Generation Inductively Coupled Plasma Atomic Emission Spectrometry (HG-ICP-AES), Electrothermal Atomization Atomic Absorption Spectrometry (ETA-AAS) and Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) were determined in term of linearity, ...

Ultra-high-resolution alpha spectrometry for nuclear forensics and safeguards applications

International Nuclear Information System (INIS)

Bacrania, Minesh K.; Croce, Mark; Bond, Evelyn; Dry, Donald; Moody, W. Allen; Lamont, Stephen; Rabin, Michael; Rim, Jung; Smith, Audrey; Beall, James; Bennett, Douglas; Kotsubo, Vincent; Horansky, Robert; Hilton, Gene; Schmidt, Daniel; Ullom, Joel; Cantor, Robin

2010-01-01

We will present our work on the development of ultra-high-resolution detectors for alpha particle spectrometry. These detectors, based on superconducting transition-edge sensors, offer energy resolution that is five to ten times better than conventional silicon detectors. Using these microcalorimeter detectors, the isotopic composition of mixed-actinide samples can be determined rapidly without the need for actinide separation chemistry to isolate each element, or mass spectrometry to separate isotopic signatures that can not be resolved using traditional alpha spectrometry (e.g. Pu-239/Pu-240, or Pu-238/Am-241). This paper will cover the detector and measurement system, actinide source preparation, and the quantitative isotopic analysis of a number of forensics- and safeguards-relevant radioactive sources.

Radiation dosimetry and spectrometry with superheated emulsions

International Nuclear Information System (INIS)

D'Errico, Francesco

2001-01-01

Detectors based on emulsions of overexpanded halocarbon droplets in tissue equivalent aqueous gels or soft polymers, known as 'superheated drop detectors' or 'bubble (damage) detectors', have been used in radiation detection, dosimetry and spectrometry for over two decades. Recent technological advances have led to the introduction of several instruments for individual and area monitoring: passive integrating meters based on the optical or volumetric registration of the bubbles, and active counters detecting bubble nucleations acoustically. These advances in the instrumentation have been matched by the progress made in the production of stable and well-specified emulsions of superheated droplets. A variety of halocarbons are employed in the formulation of the detectors, and this permits a wide range of applications. In particular, halocarbons with a moderate degree of superheat, i.e. a relatively small difference between their operating temperature and boiling point, can be used in neutron dosimetry and spectrometry since they are only nucleated by energetic heavy ions such as those produced by fast neutrons. More recently, halocarbons with an elevated degree of superheat have been utilised to produce emulsions that nucleate with much smaller energy deposition and detect low linear energy transfer radiations, such as photons and electrons. This paper reviews the detector physics of superheated emulsions and their applications in radiation measurements, particularly in neutron dosimetry and spectrometry

Separation of different ion structures in atmospheric pressure photoionization-ion mobility spectrometry-mass spectrometry (APPI-IMS-MS).

Science.gov (United States)

Laakia, Jaakko; Adamov, Alexey; Jussila, Matti; Pedersen, Christian S; Sysoev, Alexey A; Kotiaho, Tapio

2010-09-01

This study demonstrates how positive ion atmospheric pressure photoionization-ion mobility spectrometry-mass spectrometry (APPI-IMS-MS) can be used to produce different ionic forms of an analyte and how these can be separated. When hexane:toluene (9:1) is used as a solvent, 2,6-di-tert-butylpyridine (2,6-DtBPyr) and 2,6-di-tert-4-methylpyridine (2,6-DtB-4-MPyr) efficiently produce radical cations [M](+*) and protonated [M + H](+) molecules, whereas, when the sample solvent is hexane, protonated molecules are mainly formed. Interestingly, radical cations drift slower in the drift tube than the protonated molecules. It was observed that an oxygen adduct ion, [M + O(2)](+*), which was clearly seen in the mass spectra for hexane:toluene (9:1) solutions, shares the same mobility with radical cations, [M](+*). Therefore, the observed mobility order is most likely explained by oxygen adduct formation, i.e., the radical cation forming a heavier adduct. For pyridine and 2-tert-butylpyridine, only protonated molecules could be efficiently formed in the conditions used. For 1- and 2-naphthol it was observed that in hexane the protonated molecule typically had a higher intensity than the radical cation, whereas in hexane:toluene (9:1) the radical cation [M](+*) typically had a higher intensity than the protonated molecule [M + H](+). Interestingly, the latter drifts slower than the radical cation [M](+*), which is the opposite of the drift pattern seen for 2,6-DtBPyr and 2,6-DtB-4-MPyr. 2010 American Society for Mass Spectrometry. Published by Elsevier Inc. All rights reserved.

SU-8 as a material for lab-on-a-chip-based mass spectrometry.

Science.gov (United States)

Arscott, Steve

2014-10-07

This short review focuses on the application of SU-8 for the microchip-based approach to the miniaturization of mass spectrometry. Chip-based mass spectrometry will make the technology commonplace and bring benefits such as lower costs and autonomy. The chip-based miniaturization of mass spectrometry necessitates the use of new materials which are compatible with top-down fabrication involving both planar and non-planar processes. In this context, SU-8 is a very versatile epoxy-based, negative tone resist which is sensitive to ultraviolet radiation, X-rays and electron beam exposure. It has a very wide thickness range, from nanometres to millimetres, enabling the formation of mechanically rigid, very high aspect ratio, vertical, narrow width structures required to form microfluidic slots and channels for laboratory-on-a-chip design. It is also relatively chemically resistant and biologically compatible in terms of the liquid solutions used for mass spectrometry. This review looks at the impact and potential of SU-8 on the different parts of chip-based mass spectrometry - pre-treatment, ionization processes, and ion sorting and detection.

Native Mass Spectrometry in Fragment-Based Drug Discovery

Directory of Open Access Journals (Sweden)

Liliana Pedro

2016-07-01

Full Text Available The advent of native mass spectrometry (MS in 1990 led to the development of new mass spectrometry instrumentation and methodologies for the analysis of noncovalent protein–ligand complexes. Native MS has matured to become a fast, simple, highly sensitive and automatable technique with well-established utility for fragment-based drug discovery (FBDD. Native MS has the capability to directly detect weak ligand binding to proteins, to determine stoichiometry, relative or absolute binding affinities and specificities. Native MS can be used to delineate ligand-binding sites, to elucidate mechanisms of cooperativity and to study the thermodynamics of binding. This review highlights key attributes of native MS for FBDD campaigns.

Native Mass Spectrometry in Fragment-Based Drug Discovery.

Science.gov (United States)

Pedro, Liliana; Quinn, Ronald J

2016-07-28

The advent of native mass spectrometry (MS) in 1990 led to the development of new mass spectrometry instrumentation and methodologies for the analysis of noncovalent protein-ligand complexes. Native MS has matured to become a fast, simple, highly sensitive and automatable technique with well-established utility for fragment-based drug discovery (FBDD). Native MS has the capability to directly detect weak ligand binding to proteins, to determine stoichiometry, relative or absolute binding affinities and specificities. Native MS can be used to delineate ligand-binding sites, to elucidate mechanisms of cooperativity and to study the thermodynamics of binding. This review highlights key attributes of native MS for FBDD campaigns.

Gamma-ray spectrometry applied to down-hole logging

International Nuclear Information System (INIS)

Dumesnil, P.; Umiastowsky, K.

1983-11-01

Gamma-ray spectrometry permits to improve the accuracy of natural gamma, gamma-gamma and neutron-gamma geophysical measurements. The probe developed at Centre d'Etudes Nucleaires de Saclay allows down-hole gamma-ray spectrometry. Among others, this probe can be applied to the uranium content determination by selective natural gamma method, down-hole determination of the ash content in the coal by gamma-gamma selective method and elemental analysis by neutron-gamma method. For the calibration and an exact interpretation of the measurements it is important to know the gamma-ray and neutron characteristics of the different kinds of rocks considered as probabilistic variables

Advances in continuous gamma-ray spectrometry and applications

International Nuclear Information System (INIS)

Gold, R.; McNeece, J.P.; Kaiser, B.J.

1984-07-01

Recent advances and applications in continuous Compton recoil gamma-ray spectrometry are described. Applications of continuous gamma-ray spectrometry are presented for: (1) Characterization of light water reactor (LWR) pressures vessel (PV) environments. (2) Assessment of fuel distributions for Three Mile Island Unit 2 (TMI-2) reactor recovery. (3) Measurement of LWR-PV-neutron exposure. The latest improvements attained with the Janus probe, a special in-situ configuration of Si(Li) detectors, are presented. The status of current efforts to extend the domain of applicability of this method beyond 3 MeV is discussed with emphasis on recent work carried out with Si(Li) detectors of much larger volume

Use of the helium-3 proportional counter for neutron spectrometry

International Nuclear Information System (INIS)

Vialettes, H.; Le Thanh, P.

1967-01-01

Up to now, two methods have been mainly used for neutron spectrometry near nuclear installations: - photographic emulsion spectrometry - the so-called, 'multisphere' technique spectrometry. The first method, which is fairly difficult to apply, has a threshold energy of about 500 keV; this is a big disadvantage for an apparatus which has to be used for spectrometry around nuclear installations where the neutron radiation is very much degraded energetically. The second method does not suffer from this disadvantage but the results which it yields are only approximate. In order to extend the energy range of the neutron spectra studied with sufficient accuracy the use of a helium-3 proportional counter has been considered. This report presents the principles of operation of the helium-3 spectrometer, and the calculation methods which make it possible to take into account the two main effects tending to deform the spectra obtained: - energy absorption by the walls of the counter, - energy loss of the incident neutrons due to elastic collisions with helium-3 nuclei. As an example of the application, the shape of the neutron spectrum emitted by a polonium-lithium source is given; the results obtained are in excellent agreement with theoretical predictions. (authors) [fr

Laser desorption mass spectrometry for biomolecule detection and its applications

Science.gov (United States)

Winston Chen, C. H.; Sammartano, L. J.; Isola, N. R.; Allman, S. L.

2001-08-01

During the past few years, we developed and used laser desorption mass spectrometry for biomolecule detections. Matrix-assisted laser desorption/ionization (MALDI) was successfully used to detect DNA fragments with the size larger than 3000 base pairs. It was also successfully used to sequence DNA with both enzymatic and chemical degradation methods to produce DNA ladders. We also developed MALDI with fragmentation for direct DNA sequencing for short DNA probes. Since laser desorption mass spectrometry for DNA detection has the advantages of fast speed and no need of labeling, it has a great potential for molecular diagnosis for disease and person identification by DNA fingerprinting. We applied laser desorption mass spectrometry to succeed in the diagnosis of cystic fibrosis and several other nerve degenerative diseases such as Huntington's disease. We also succeeded in demonstrating DNA typing for forensic applications.

Laser desorption mass spectrometry for biomolecule detection and its applications

International Nuclear Information System (INIS)

Winston Chen, C.H.; Allman, S.L.; Sammartano, L.J.; Isola, N.R.

2001-01-01

During the past few years, we developed and used laser desorption mass spectrometry for biomolecule detections. Matrix-assisted laser desorption/ionization (MALDI) was successfully used to detect DNA fragments with the size larger than 3000 base pairs. It was also successfully used to sequence DNA with both enzymatic and chemical degradation methods to produce DNA ladders. We also developed MALDI with fragmentation for direct DNA sequencing for short DNA probes. Since laser desorption mass spectrometry for DNA detection has the advantages of fast speed and no need of labeling, it has a great potential for molecular diagnosis for disease and person identification by DNA fingerprinting. We applied laser desorption mass spectrometry to succeed in the diagnosis of cystic fibrosis and several other nerve degenerative diseases such as Huntington's disease. We also succeeded in demonstrating DNA typing for forensic applications

Neutron spectrometry for reactor applications: status, limitations, and future directions

International Nuclear Information System (INIS)

Gold, R.

1975-08-01

The ability of ''state-of-the-art'' reactor neutron spectrometry to provide definitive environmental results required for high fluence radiation damage experiments is reviewed. A formal definition of the neutron component is presented as well as general considerations which accrue from both this definition and the existence of the mixed radiation field generally encountered in reactors. A description of four selected methods of reactor neutron spectrometry is included, namely Proton Recoil (PR) methods, Time-Of-Flight (TOF) methods, the 6 Li(n,α) 3 H coincidence method, and Multiple Foil Activation (MFA) methods. These selected methods are compared. Future requirements and directions for reactor neutron spectrometry are discussed. In particular, the needs of future CTR research are stressed and the He 4 - recoil proportional counter spectroscopy method is advanced as a means of meeting these future requirements. 50 references. (auth)

Liquid chromatography-mass spectrometry in forensic toxicology.

Science.gov (United States)

Van Bocxlaer, J F; Clauwaert, K M; Lambert, W E; Deforce, D L; Van den Eeckhout, E G; De Leenheer, A P

2000-01-01

Liquid chromatography-mass spectrometry has evolved from a topic of mainly research interest into a routinely usable tool in various application fields. With the advent of new ionization approaches, especially atmospheric pressure, the technique has established itself firmly in many areas of research. Although many applications prove that LC-MS is a valuable complementary analytical tool to GC-MS and has the potential to largely extend the application field of mass spectrometry to hitherto "MS-phobic" molecules, we must recognize that the use of LC-MS in forensic toxicology remains relatively rare. This rarity is all the more surprising because forensic toxicologists find themselves often confronted with the daunting task of actually searching for evidence materials on a scientific basis without any indication of the direction in which to search. Through the years, mass spectrometry, mainly in the GC-MS form, has gained a leading role in the way such quandaries are tackled. The advent of robust, bioanalytically compatible combinations of liquid chromatographic separation with mass spectrometric detection really opens new perspectives in terms of mass spectrometric identification of difficult molecules (e.g., polar metabolites) or biopolymers with toxicological relevance, high throughput, and versatility. Of course, analytical toxicologists are generally mass spectrometry users rather than mass spectrometrists, and this difference certainly explains the slow start of LC-MS in this field. Nevertheless, some valuable applications have been published, and it seems that the introduction of the more universal atmospheric pressure ionization interfaces really has boosted interests. This review presents an overview of what has been realized in forensic toxicological LC-MS. After a short introduction into LC-MS interfacing operational characteristics (or limitations), it covers applications that range from illicit drugs to often abused prescription medicines and some

Measurements of uranium enrichment by four techniques of gamma-ray spectrometry

International Nuclear Information System (INIS)

Tojo, Takao

1983-12-01

Measurements of uranium enrichment with the uses of the LMRI (France) UO 2 standards have been made by four techniques of gamma-ray spectrometry, in order to examine measurement characteristics of each technique. The following results were obtained by the three techniques based on the direct determination of the peak area of the 186-keV gamma-rays from 235 U, when the standard sample of 6.297 a/o was used for measuring enrichments ranging from 1.4 a/o to 9.6 a/o ; (i) In a LEPS HP Ge gamma-ray spectrometry, standard deviation of the measured enrichments from the certified ones was 1.4 %, (ii) in a Ge(Li) gamma-ray spectrometry, the standard deviation was 2.0 %, (iii) in a NaI(Tl) gamma-ray spectrometry, the standard deviation was 1.2 %. In the fourth technique, the method of multiple single-channel analyzers, enrichments of 1.4 - 9.6 a/o were measured in the standard deviation of 0.51 %, when the most suitable pairs of standard samples were used for each sample. A part of sources of systematic errors which were caused by each technique adopted was revealed throughout the measurements. And also, it was recognized that the LMRI's values of enrichment were certified precisely, and the UO 2 standards were very useful for enrichment measurements in the four techniques of gamma-ray spectrometry used here. (author)

Impact of automation on mass spectrometry.

Science.gov (United States)

Zhang, Yan Victoria; Rockwood, Alan

2015-10-23

Mass spectrometry coupled to liquid chromatography (LC-MS and LC-MS/MS) is an analytical technique that has rapidly grown in popularity in clinical practice. In contrast to traditional technology, mass spectrometry is superior in many respects including resolution, specificity, multiplex capability and has the ability to measure analytes in various matrices. Despite these advantages, LC-MS/MS remains high cost, labor intensive and has limited throughput. This specialized technology requires highly trained personnel and therefore has largely been limited to large institutions, academic organizations and reference laboratories. Advances in automation will be paramount to break through this bottleneck and increase its appeal for routine use. This article reviews these challenges, shares perspectives on essential features for LC-MS/MS total automation and proposes a step-wise and incremental approach to achieve total automation through reducing human intervention, increasing throughput and eventually integrating the LC-MS/MS system into the automated clinical laboratory operations. Copyright © 2015 Elsevier B.V. All rights reserved.

Mass Spectrometry on Future Mars Landers

Science.gov (United States)

Brinckerhoff, W. B.; Mahaffy, P. R.

2011-01-01

Mass spectrometry investigations on the 2011 Mars Science Laboratory (MSL) and the 2018 ExoMars missions will address core science objectives related to the potential habitability of their landing site environments and more generally the near-surface organic inventory of Mars. The analysis of complex solid samples by mass spectrometry is a well-known approach that can provide a broad and sensitive survey of organic and inorganic compounds as well as supportive data for mineralogical analysis. The science value of such compositional information is maximized when one appreciates the particular opportunities and limitations of in situ analysis with resource-constrained instrumentation in the context of a complete science payload and applied to materials found in a particular environment. The Sample Analysis at Mars (SAM) investigation on MSL and the Mars Organic Molecule Analyzer (MOMA) investigation on ExoMars will thus benefit from and inform broad-based analog field site work linked to the Mars environments where such analysis will occur.

Auger spectrometry of atoms and molecules

International Nuclear Information System (INIS)

Krause, M.O.

1994-01-01

The author discusses the importance of Auger spectrometry at synchrotron radiation centers. First, he explains how a high energy photon source such as the APS (Advanced Photon Source) could be used to help provide missing spectral information about the shell structure of some elements. The missing data occurs mainly at higher energies in the 1--10 keV ranges as for the K-shells of Z = 30 to 60 elements and the L-shells for Z = 30 to 100 elements. He explains how even though Auger electron spectrometry does not depend on synchrotron radiation it can greatly benefit from this variable photon source as it allows one to select the Auger line group that is most suitable for a specific purpose. Most significantly, a continuous photon source becomes indispensable when one is interested in threshold effects. Lastly, he discusses coherence effects between different inner-shell vacancy states by way of some recent work done at Daresbury

Use of mass spectrometry for study of coordination compounds

International Nuclear Information System (INIS)

Gehrbehlehu, N.V.; Indrichan, K.M.

1981-01-01

A review on mass-spectrometry of coordination compounds including the works published up to 1979 inclusive is provided. Mainly the products of metals with bi- and tetradentate ligands are considered using the method. Mo and Be carboxylates for which molecular ions lines are found in mass-spectra are studied. The study of mass-spectra for VO chelates with thiosemicarbazone of salicyl aldehyde is carried out. Application of the mass-spectrometry method permits to establish the mass of coordination compounds, the structure of complexes, dentate structure and the way of ligand coordination, the bond strength [ru

Nanoscience, nanotechnology and spectrometry

International Nuclear Information System (INIS)

Adams, Freddy C.; Barbante, Carlo

2013-01-01

Nanoscience has outgrown its infancy, and nanotechnology has found important applications in our daily life — with many more to come. Although the central concepts of the nano world, namely the changes of particular physical properties on the length scale of individual atoms and molecules, have been known and developed for quite some time already, experimental advances since the 1980s and recognition of the potential of nanomaterials led to a genuine breakthrough of the inherently multidisciplinary nanoscience field. Analytical nanoscience and nanotechnology and especially the use of micro and nano electro mechanical systems, of the quantum dots and of mass spectrometry, currently provide one of the most promising avenues for developments in analytical science, derived from their two main fields of action, namely (a) the analysis of nano-structured materials and (b) their use as new tools for analysis. An overview is given of recent developments and trends in the field, highlighting the importance and point out future directions, while also touching drawbacks, such as emerging concerns about health and environmental issues. - Highlights: • We review the analysis of nano-structured materials. • Nano-structured materials can be used as new tools for analysis. • Use of nano electro mechanical systems, of quantum dots and of mass spectrometry • Nanotechnologies are among the most promising tools in analytical science

Nanoscience, nanotechnology and spectrometry

Energy Technology Data Exchange (ETDEWEB)

Adams, Freddy C. [Department of Chemistry, University of Antwerp, B-2610 Wilrijk (Belgium); Barbante, Carlo, E-mail: barbante@unive.it [Institute for the Dynamics of Environmental Processes — CNR, Venice (Italy); Department of Environmental Sciences, Informatics and Statistics, Ca' Foscari University, Venice (Italy)

2013-08-01

Nanoscience has outgrown its infancy, and nanotechnology has found important applications in our daily life — with many more to come. Although the central concepts of the nano world, namely the changes of particular physical properties on the length scale of individual atoms and molecules, have been known and developed for quite some time already, experimental advances since the 1980s and recognition of the potential of nanomaterials led to a genuine breakthrough of the inherently multidisciplinary nanoscience field. Analytical nanoscience and nanotechnology and especially the use of micro and nano electro mechanical systems, of the quantum dots and of mass spectrometry, currently provide one of the most promising avenues for developments in analytical science, derived from their two main fields of action, namely (a) the analysis of nano-structured materials and (b) their use as new tools for analysis. An overview is given of recent developments and trends in the field, highlighting the importance and point out future directions, while also touching drawbacks, such as emerging concerns about health and environmental issues. - Highlights: • We review the analysis of nano-structured materials. • Nano-structured materials can be used as new tools for analysis. • Use of nano electro mechanical systems, of quantum dots and of mass spectrometry • Nanotechnologies are among the most promising tools in analytical science.

Stable isotope mass spectrometry in petroleum exploration

International Nuclear Information System (INIS)

Mathur, Manju

1997-01-01

The stable isotope mass spectrometry plays an important role to evaluate the stable isotopic composition of hydrocarbons. The isotopic ratios of certain elements in petroleum samples reflect certain characteristics which are useful for petroleum exploration

Quantitative mass spectrometry: an overview

Science.gov (United States)

Urban, Pawel L.

2016-10-01

Mass spectrometry (MS) is a mainstream chemical analysis technique in the twenty-first century. It has contributed to numerous discoveries in chemistry, physics and biochemistry. Hundreds of research laboratories scattered all over the world use MS every day to investigate fundamental phenomena on the molecular level. MS is also widely used by industry-especially in drug discovery, quality control and food safety protocols. In some cases, mass spectrometers are indispensable and irreplaceable by any other metrological tools. The uniqueness of MS is due to the fact that it enables direct identification of molecules based on the mass-to-charge ratios as well as fragmentation patterns. Thus, for several decades now, MS has been used in qualitative chemical analysis. To address the pressing need for quantitative molecular measurements, a number of laboratories focused on technological and methodological improvements that could render MS a fully quantitative metrological platform. In this theme issue, the experts working for some of those laboratories share their knowledge and enthusiasm about quantitative MS. I hope this theme issue will benefit readers, and foster fundamental and applied research based on quantitative MS measurements. This article is part of the themed issue 'Quantitative mass spectrometry'.

Diagnostic X-ray spectrometry using a commercial CdZnTe detector

International Nuclear Information System (INIS)

Becker, P.H.B.

1998-01-01

X ray spectrometry using Ge or Si detectors is an established tool to measure characterization parameters of X-ray beams. This work describes how a commercial CdZnTe was used to perform diagnostic X-ray spectrometry. Spectra were measured for two X-ray machines and compared with similar data found in the literature with an agreement of 2% rms

Pyrolysis - gas chromatography - mass spectrometry of lignins

Energy Technology Data Exchange (ETDEWEB)

Martin, F; Saiz-Jimenez, C; Gonzalez-Vila, F J

1979-01-01

Milled wood lignins from spruce, beech and bamboo were pyrolysed. The high-boiling products of pyrolysis were studied by GLC and mass spectrometry. The forty-three products identified provide information on the structural units of lignin.

Mass spectrometry in structural biology and biophysics architecture, dynamics, and interaction of biomolecules

CERN Document Server

Kaltashov, Igor A; Desiderio, Dominic M; Nibbering, Nico M

2012-01-01

The definitive guide to mass spectrometry techniques in biology and biophysics The use of mass spectrometry (MS) to study the architecture and dynamics of proteins is increasingly common within the biophysical community, and Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics, and Interaction of Biomolecules, Second Edition provides readers with detailed, systematic coverage of the current state of the art. Offering an unrivalled overview of modern MS-based armamentarium that can be used to solve the most challenging problems in biophysics, structural biol