WorldWideScience

Sample records for specific pet radioisotopes

  1. Summary report of consultants' meeting on high-precision beta-intensity measurements and evaluations for specific PET radioisotopes

    International Nuclear Information System (INIS)

    Capote Noy, R.; Nicols, A.L.

    2009-12-01

    A summary is given of a Consultants' Meeting on 'High-precision beta-intensity measurements and evaluations for specific PET radioisotopes'. Participants assessed and reviewed the decay data for close to 50 positron-emitting radionuclides. Technical discussions are described in this report, along with the detailed recommendations and a priority list for future work. Direct positron and X-ray measurements are required to resolve a significant number of outstanding issues associated with the radionuclides reviewed. The following new measurements are recommended: gamma-ray emission probability for Cu-64, positron and Xray emission probabilities for Ni-57, Cu-62, Ga-66, As-72, Se-73, Rb-81,82m, Sr-83, Y-86 and Tc-94m. The following immediate evaluations were also recommended: Br-76 and I-120g.. Participants assessed and reviewed the decay data for close to 50 positron-emitting radionuclides. Technical discussions are described in this report, along with the detailed recommendations and a priority list for future work. Direct positron and X-ray measurements are required to resolve a significant number of outstanding issues associated with the radionuclides reviewed. The following new measurements are recommended: gamma-ray emission probability for Cu-64, positron and Xray emission probabilities for Ni-57, Cu-62, Ga-66, As-72, Se-73, Rb-81,82m, Sr-83, Y-86 and Tc-94m. The following immediate evaluations were also recommended: Br-76 and I-120g. (author)

  2. Potential medical applications of the plasma focus in the radioisotope production for PET imaging

    International Nuclear Information System (INIS)

    Roshan, M.V.; Razaghi, S.; Asghari, F.; Rawat, R.S.; Springham, S.V.; Lee, P.; Lee, S.; Tan, T.L.

    2014-01-01

    Devices other than the accelerators are desired to be investigated for generating high energy particles to induce nuclear reaction and positron emission tomography (PET) producing radioisotopes. The experimental data of plasma focus devices (PF) are studied and the activity scaling law for External Solid Target (EST) activation is established. Based on the scaling law and the techniques to enhance the radioisotopes production, the feasibility of generating the required activity for PET imaging is studied. - Highlights: • Short lived radioisotopes for PET imaging are produced in plasma focus device. • The scaling law of the activity induced with plasma focus energy is established. • The potential medical applications of plasma focus are studied

  3. Cyclotron-produced radioisotopes and their clinical use at the Austin PET Centre

    Energy Technology Data Exchange (ETDEWEB)

    Tochon-Danguy, H.J. [Centre for PET, Melbourne, VIC (Australia). Austin and Repatriation Medical Centre

    1997-12-31

    A Centre for Positron Emission Tomography (PET) has been established within the Department of Nuclear Medicine at the Austin and Repatriation Medical Centre in Melbourne. PET is a non-invasive technique based on the use of biologically relevant compounds labelled with short-lived positron-emitting radionuclides such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18. The basic equipment consists of a medical cyclotron (10 MeV proton and 5 MeV deuteron), six lead-shielded hot cells with associated radiochemistry facilities and a whole body PET scanner. During its first five years of operation, the Melbourne PET Centre, has pursued a strong radiolabelling development program, leading to an ambitious clinical program in neurology, oncology and cardiology. This presentation will describe the basic principles of the PET technique and review the cyclotron-produced radioisotopes and radiopharmaceuticals. Radiolabelling development programs and clinical applications are also addressed. 30 refs., 1 tab., 1 fig.

  4. Cyclotron-produced radioisotopes and their clinical use at the Austin PET Centre

    International Nuclear Information System (INIS)

    Tochon-Danguy, H.J.

    1997-01-01

    A Centre for Positron Emission Tomography (PET) has been established within the Department of Nuclear Medicine at the Austin and Repatriation Medical Centre in Melbourne. PET is a non-invasive technique based on the use of biologically relevant compounds labelled with short-lived positron-emitting radionuclides such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18. The basic equipment consists of a medical cyclotron (10 MeV proton and 5 MeV deuteron), six lead-shielded hot cells with associated radiochemistry facilities and a whole body PET scanner. During its first five years of operation, the Melbourne PET Centre, has pursued a strong radiolabelling development program, leading to an ambitious clinical program in neurology, oncology and cardiology. This presentation will describe the basic principles of the PET technique and review the cyclotron-produced radioisotopes and radiopharmaceuticals. Radiolabelling development programs and clinical applications are also addressed

  5. Commercial and PET radioisotope manufacturing with a medical cyclotron

    International Nuclear Information System (INIS)

    Boothe, T.E.; McLeod, T.F.; Plitnikas, M.; Kinney, D.; Tavano, E.; Feijoo, Y.; Smith, P.; Szelecsenyi, F.

    1993-01-01

    Mount Sinai has extensive experience in producing radionuclides for commercial sales and for incorporation into radiopharmaceuticals, including PET. Currently, an attempt is being made to supply radiochemicals to radiopharmaceutical manufacturers outside the hospital, to prepare radiopharmaceuticals for in-house use, and to prepare PET radiopharmaceuticals, such as 2-[F-18] FDG, for outside sales. This use for both commercial and PET manufacturing is atypical for a hospital-based cyclotron. To accomplish PET radiopharmaceutical sales, the hospital operates a nuclear pharmacy. A review of operational details for the past several years shows a continuing dependence on commercial sales which is reflected in research and developmental aspects and in staffing. Developmental efforts have centered primarily on radionuclide production, target development, and radiochemical processing optimization. (orig.)

  6. Commercial and PET radioisotope manufacturing with a medical cyclotron

    Science.gov (United States)

    Boothe, T. E.; McLeod, T. F.; Plitnikas, M.; Kinney, D.; Tavano, E.; Feijoo, Y.; Smith, P.; Szelecsényi, F.

    1993-06-01

    Mount Sinai has extensive experience in producing radionuclides for commercial sales and for incorporation into radiopharmaceuticals, including PET. Currently, an attempt is being made to supply radiochemicals to radiopharmaceutical manufacturers outside the hospital, to prepare radiopharmaceuticals for in-house use, and to prepare PET radiopharmaceuticals, such as 2-[F-18] FDG, for outside sales. This use for both commercial and PET manufacturing is atypical for a hospital-based cyclotron. To accomplish PET radiopharmaceutical sales, the hospital operates a nuclear pharmacy. A review of operational details for the past several years shows a continuing dependence on commercial sales which is reflected in research and developmental aspects and in staffing. Developmental efforts have centered primarily on radionuclide production, target development, and radiochemical processing optimization.

  7. Design considerations for foil windows for PET radioisotope targets

    International Nuclear Information System (INIS)

    Hughey, B.J.; Shefer, R.E.; Klinkowstein, R.E.; Welch, M.J.

    1992-01-01

    This paper describes the results of a study performed at SRL to develop analytical and computational techniques for optimizing the design of conduction-cooled foil windows for PET targets. Single foil conduction cooled windows have been found to be good target entrance windows for both low energy accelerators and medium energy cyclotrons. Detailed thermal analysis has given an approximate analytical expression for the maximum temperature reached in a foil window under conditions of realistic ion beam bombardment. The effects of 'hot spots' in the beam density profile were investigated. It was shown that a factor of two safety margin in window design should be adequate to compensate for any possible beam hot spots. In addition, the reduction of foil stress by slack mounting was verified by experiments. The properties of conventional and novel foil materials were investigated for use in conduction cooled windows. Novel foil materials include two-component Al/Ti and Al/Havar foil. Results on the testing of candidate foil materials for thermal conductivity and mechanical strength at elevated temperature were presented. Two optimum foil window geometries were analyzed: a high aspect ratio window and a multiply slotted window. The multiply slotted window combines the advantages of a high aspect ratio foil window with a circular beam strike and is a promising window design for both TCA and cyclotron targets. A multiply slotted window for a N 2 gas target for 15 O production was designed using the methodologies discussed above. This prototype target was successfully tested using the TCA beam at SRL. (author) 6 figs., 3 tabs., 10 refs

  8. Digital PET compliance to EARL accreditation specifications

    NARCIS (Netherlands)

    Koopman, Daniëlle; Groot Koerkamp, Maureen; Jager, Pieter L.; Arkies, Hester; Knollema, Siert; Slump, Cornelis H.; Sanches, Pedro G.; van Dalen, Jorn A.

    2017-01-01

    Background: Our aim was to evaluate if a recently introduced TOF PET system with digital photon counting technology (Philips Healthcare), potentially providing an improved image quality over analogue systems, can fulfil EANM research Ltd (EARL) accreditation specifications for tumour imaging with

  9. Procedures for evaluating technical specifications (PETS)

    International Nuclear Information System (INIS)

    Samanta, P.K.; Boccio, J.L.; Vesely, W.E.

    1987-01-01

    In this paper, aspects of technical specifications relating to Generic Issues B-56 and B-61 are discussed from a risk-standpoint. These primarily deal with the risk issues associated with (1) adaptive diesel test requirements/surveillance test intervals, and (2) the effectiveness of cumulative outage time requirements for controlling downtime risk. Risk and reliability approaches are presented which (1) allow risk-acceptable test intervals to be determined for any diesel and (2) show the potential risk-control capability of prescribed allowed cumulative outage times. This work was conducted through NRC's Procedures for Evaluating Technical Specifications (PETS) Program. The overall objective of this program is to develop and demonstrate methodologies that utilize risk insights and reliability techniques for evaluating the scope, detailed requirements, and safety impact of plant technical specifications

  10. Five Years of Cyclotron Radioisotope Production Experiences at the First PET-CT in Venezuela

    International Nuclear Information System (INIS)

    Colmenter, L.; Coelho, D.; Esteves, L. M.; Ruiz, N.; Morales, L.; Lugo, I.; Sajo-Bohus, L.; Liendo, J. A.; Greaves, E. D.; Barros, H.; Castillo, J.

    2007-01-01

    Five years operation of a compact cyclotron installed at PET-CT facility in Caracas, Venezuela is given. Production rate of 18 F labeled FDG, operation and radiation monitoring experience are included. We conclude that 18 FDG CT-PET is the most effective technique for patient diagnosis

  11. Transmission factors for neutrons produced by radioisotopes production used in PET

    International Nuclear Information System (INIS)

    Hernandez G, D.; Cruzate, J.A.

    1996-01-01

    The dose transmission factor for normal concrete and the neutrons produced in the 18 O(p,n) 18 F and 13 C(p,n) 13 N reactions are presented in this paper. These transmission factors permit to simplify the calculation of the necessary accelerator shielding to be used in the radioisotope production for positron emission tomography. The energy distributions of the neutrons resulting from the irradiation of thick targets, with 10 to 13 MeV protons, were determined using the thin target cross sections, the energy loss per path length and the energy balance of the reaction (Q-equation). The one dimensional discrete ordinate transport code ANISN and the conversion coefficients from fluence to dose, presented in the ICRP Publication 51 were employed to obtain the transmission factors. (authors). 12 refs., 3 figs., 2 tabs

  12. Production and quality control of 66 Ga as a PET radioisotope

    International Nuclear Information System (INIS)

    Rowshanfarzad, P.; Jalilian, A. R.; Akhlaghi, M.; Sabet, M.

    2004-01-01

    Background: 66 Ga (t 1/2 =9.49 h, β + : 4.153 MeV, γ: 511, 834, 1039, 2752 keV) has a wide range of applications in different fields of medical sciences. Production of 66 Ga became one of our main interests, according to its increasing applications in nuclear medicine, particularly in PET imaging. Materials and Methods: 66 Zn (p,n) 66 Ga reaction was determined as the best choice for the production of 66 Ga, according to the present facilities and conditions. The bombardment was performed by 15 MeV protons in Cyclone 30-IBA accelerator with a current intensity of 180 μA for 67 min. ALICE nuclear code and SRIM nuclear program were used to determine the optimum energy and target thickness. Targets were prepared by electroplating of 66 Zn (>95%) on a copper backing. Chemical processing was performed by a no carrier added method consisting of ion exchange chromatography and liquid-liquid extraction. Anion exchange chromatography was used for the recovery of target material. Quality control of the product was carried out in two steps of chemical and radionuclidic purity control. Results: the activity of 66 Ga was 2.41 Ci at the end of bombardment and the production yield was 12.04 mCi/μAh. The chemical separation yield was 93% and the yield of chemical recovery of the target material was 97%. Quality control tests showed a radionuclidic purity of more than 97% and the amounts of chemical impurities were in accordance with standard levels. Discussion: Our production yield was comparable with previous reports given in the literature. The chemical separation method used in this research was simple and brought up acceptable results. So, this process can be considered as one of the best choices for the production of 66 Ga

  13. Organic synthesis with short-lived positron-emitting radioisotopes

    International Nuclear Information System (INIS)

    Pike, V.W.

    1988-01-01

    Chemistry with short-lived positron-emitting radioisotopes of the non-metals, principally 11 C, 13 N and 18 F, has burgeoned over the last decade. This has been almost entirely because of the emergence of positron emission tomography (PET) as a powerful non-invasive technique for investigating pathophysiology in living man. PET is essentially an external technique for the rapid serial reconstruction of the spatial distribution of any positron-emitting radioisotope that has been administered in vivo. Such a distribution is primarily governed by the chemical form in which the positron-emitting radioisotope is incorporated, and importantly for clinical research, is often perturbed by physical, biological or clinical factors. Judicious choice of the chemical form enables specific biological information to be obtained. For example, the labelling of glucose with a positron-emitting radioisotope could be expected to provide a radiopharmaceutical for the study of glucose utilisation in both health and disease. (author)

  14. The Synthesis And Characterization Of Wolfram Phthalocyanine For The Target Material Of High Specific Activity Radioisotope Wolfram - 188 (188W)

    International Nuclear Information System (INIS)

    Setiawan, Duyeh

    2000-01-01

    The application of 188 Re radioisotope separation on aluminia column through elution solution has increased significantly since the last two decades. The 188 Re radioisotope has been done fram 188 Re beta-decay through a neutron capture radiation on wolfram -186 target. In trhe column separation, high specific activity of 188 W radioisotope is required to get sufficient activity in small quality 188 W radioisotope has been carried out in this research. Wolfram-phthalocyanine compound was prepared by refluxing a mixture of wolfram trioxyde, (WO 3 ) and phthalonitrile, (C 8 H 4 N 2 ) at 250 o C for two hours. The synthesis of wolfram phthalocyanine is 70% purity yield, the product are green crystals, have a 193,0-193,8 o C melting points, and has a molecular formula C 3 2H 1 6 N8 WO 2 . The infra red spectrum of wolfram-phthalocyanine was the absorption band at 964,3 cm - 1 was due to the vibration of W=O bond of the wolfram dioxy-phthalocyanine. The x-ray diffraction of the wolfram dioxy-phthalocyanine was similar with molybdenum dioxy-phthalocyanine compound. This fact showed that the product was wolfram dioxy-phthalocyanine

  15. Radioisotope instruments

    CERN Document Server

    Cameron, J F; Silverleaf, D J

    1971-01-01

    International Series of Monographs in Nuclear Energy, Volume 107: Radioisotope Instruments, Part 1 focuses on the design and applications of instruments based on the radiation released by radioactive substances. The book first offers information on the physical basis of radioisotope instruments; technical and economic advantages of radioisotope instruments; and radiation hazard. The manuscript then discusses commercial radioisotope instruments, including radiation sources and detectors, computing and control units, and measuring heads. The text describes the applications of radioisotop

  16. Experience utilizing a 3.7 MeV tandem cascade accelerator (TCA) for PET radioisotope production

    International Nuclear Information System (INIS)

    Welch, M.J.; Gaehle, G.; Dence, C.S.

    1994-01-01

    A 3.7 MeV TCA was installed at Washington University in the Spring of 1993 for evaluation as a PET isotope production accelerator. The accelerator was installed in a specially designed suite consisting of the accelerator room, a open-quotes hot labclose quotes and a open-quotes cold labclose quotes. The accelerator has been utilized routinely for PET isotope production since it's installation. Although the major radionuclide produced utilizing the TCA is oxygen-15, techniques for the production of fluorine-18 and nitrogen-13 have been developed. The novel techniques used to produce usable quantities of these latter two isotopes will be discussed

  17. Advances in prostate-specific membrane antigen PET of prostate cancer.

    Science.gov (United States)

    Bouchelouche, Kirsten; Choyke, Peter L

    2018-05-01

    In recent years, a large number of reports have been published on prostate-specific membrane antigen (PSMA)/PET in prostate cancer (PCa). This review highlights advances in PSMA PET in PCa during the past year. PSMA PET/computed tomography (CT) is useful in detection of biochemical recurrence, especially at low prostate-specific antigen (PSA) values. The detection rate of PSMA PET is influenced by PSA level. For primary PCa, PSMA PET/CT shows promise for tumour localization in the prostate, especially in combination with multiparametric MRI (mpMRI). For primary staging, PSMA PET/CT can be used in intermediate and high-risk PCa. Intraoperative PSMA radioligand guidance seems promising for detection of malignant lymph nodes. While the use of PSMA PET/MRI in primary localized disease is limited to high and intermediate-risk patients and localized staging, in the recurrence setting, PET/MRI can be particularly helpful when the lesions are subtle. PSMA PET/CT is superior to choline PET/CT and other conventional imaging modalities. Molecular imaging with PSMA PET continues to pave the way for personalized medicine in PCa.However, large prospective clinical studies are still needed to fully evaluate the role of PSMA PET/CT and PET/MRI in the clinical workflow of PCa.

  18. Radioisotopes production and applications

    International Nuclear Information System (INIS)

    Dash, Ashutosh

    2015-01-01

    Application of radioisotopes for both medical and industrial applications constitutes one of the most important peaceful uses of atomic energy. The striking diffusion and the exciting perspective of radioisotope for a plethora of medical and industrial applications are mainly attributable to the penetrating and ionization properties of radiation emanating from radioisotopes. The revolutionary medical applications of radioisotopes for the diagnosis and treatment of a multitude of diseases are causing a rapid expansion of the nuclear medicine field. While the industrial uses of radioisotopes are not expanding as quickly, also require large amounts of radioisotopes. Production of radioisotopes is not only the first step, but also the most crucial for the success as well as sustainable growth of radioisotope applications. With the rapid growth and expanding areas of applications, the demands for isotopes have increased several folds. A number of radioisotopes of different physical half-life, energy of the particle or gamma emission, specific activity and chemistry are now regularly produced both at commercial centers as well as at selected nuclear science research institutes utilizing reactors and cyclotrons to meet the ever growing need

  19. Development of a new chemical introduction process for hours living radioisotope and it's application for PET imaging agent

    International Nuclear Information System (INIS)

    Kurihara, Masaaki

    2004-01-01

    A new chemical introduction process of fluorine-18, 18 F was developed using solid phase synthesis technique, instead of a conventional liquid phase synthesis. Separation for a plenty of non-reaction compound was difficult in the liquid phase synthesis technique. Precursor compound reacted on the surface of solid phase (beads). Labeled compound with 18 F could be separated from the solid surface by reaction of fluoride reagent. A fundamental fluoric reaction was developed with the solid phase process. Sulfonyl chloride, polymer-bound 1 was used as a solid phase carrier of the precursor. The 18 F-FDG, which are replaced a hydroxyl group in D-glucose with 18 F, were used most frequently as a cancer marker in positron computed tomography (PET). Synthesis of the 18 F-FDG was investigated by the solid phase technique. (M. Suetake)

  20. Specific recommendations for accurate and direct use of PET-CT in PET guided radiotherapy for head and neck sites

    International Nuclear Information System (INIS)

    Thomas, C. M.; Convery, D. J.; Greener, A. G.; Pike, L. C.; Baker, S.; Woods, E.; Hartill, C. E.

    2014-01-01

    Purpose: To provide specific experience-based guidance and recommendations for centers wishing to develop, validate, and implement an accurate and efficient process for directly using positron emission tomography-computed tomography (PET-CT) for the radiotherapy planning of head and neck cancer patients. Methods: A PET-CT system was modified with hard-top couch, external lasers and radiotherapy immobilization and indexing devices and was subject to a commissioning and quality assurance program. PET-CT imaging protocols were developed specifically for radiotherapy planning and the image quality and pathway tested using phantoms and five patients recruited into an in-house study. Security and accuracy of data transfer was tested throughout the whole data pathway. The patient pathway was fully established and tested ready for implementation in a PET-guided dose-escalation trial for head and neck cancer patients. Results: Couch deflection was greater than for departmental CT simulator machines. An area of high attenuation in the couch generated image artifacts and adjustments were made accordingly. Using newly developed protocols CT image quality was suitable to maintain delineation and treatment accuracy. Upon transfer of data to the treatment planning system a half pixel offset between PET and CT was observed and corrected. By taking this into account, PET to CT alignment accuracy was maintained below 1 mm in all systems in the data pathway. Transfer of structures delineated in the PET fusion software to the radiotherapy treatment planning system was validated. Conclusions: A method to perform direct PET-guided radiotherapy planning was successfully validated and specific recommendations were developed to assist other centers. Of major concern is ensuring that the quality of PET and CT data is appropriate for radiotherapy treatment planning and on-treatment verification. Couch movements can be compromised, bore-size can be a limitation for certain immobilization

  1. Specific recommendations for accurate and direct use of PET-CT in PET guided radiotherapy for head and neck sites

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, C. M., E-mail: christopher.thomas@gstt.nhs.uk; Convery, D. J.; Greener, A. G. [Guy' s and St. Thomas’ NHS Foundation Trust, Medical Physics Department, St. Thomas’ Hospital, London SE1 7EH (United Kingdom); Pike, L. C.; Baker, S.; Woods, E. [Division of Imaging Sciences and Biomedical Engineering, King' s College London, King' s Health Partners, St. Thomas’ Hospital, London SE1 7EH (United Kingdom); Hartill, C. E. [Guy' s and St. Thomas’ NHS Foundation Trust, Radiotherapy, Clinical Outpatients Clinic, St. Thomas’ Hospital, London SE1 7EH (United Kingdom)

    2014-04-15

    Purpose: To provide specific experience-based guidance and recommendations for centers wishing to develop, validate, and implement an accurate and efficient process for directly using positron emission tomography-computed tomography (PET-CT) for the radiotherapy planning of head and neck cancer patients. Methods: A PET-CT system was modified with hard-top couch, external lasers and radiotherapy immobilization and indexing devices and was subject to a commissioning and quality assurance program. PET-CT imaging protocols were developed specifically for radiotherapy planning and the image quality and pathway tested using phantoms and five patients recruited into an in-house study. Security and accuracy of data transfer was tested throughout the whole data pathway. The patient pathway was fully established and tested ready for implementation in a PET-guided dose-escalation trial for head and neck cancer patients. Results: Couch deflection was greater than for departmental CT simulator machines. An area of high attenuation in the couch generated image artifacts and adjustments were made accordingly. Using newly developed protocols CT image quality was suitable to maintain delineation and treatment accuracy. Upon transfer of data to the treatment planning system a half pixel offset between PET and CT was observed and corrected. By taking this into account, PET to CT alignment accuracy was maintained below 1 mm in all systems in the data pathway. Transfer of structures delineated in the PET fusion software to the radiotherapy treatment planning system was validated. Conclusions: A method to perform direct PET-guided radiotherapy planning was successfully validated and specific recommendations were developed to assist other centers. Of major concern is ensuring that the quality of PET and CT data is appropriate for radiotherapy treatment planning and on-treatment verification. Couch movements can be compromised, bore-size can be a limitation for certain immobilization

  2. Application of radioisotopes in entomology

    International Nuclear Information System (INIS)

    Saour, G.

    1995-01-01

    Radioisotope techniques are effective in entomology and studies on insects physiology. The study presents the use of radioisotopes in pest control programs: Methods of insects irradiation and the concept of biological half-life of the radioisotopes in comparison with physical half-life are explained. Main radioisotopes used in entomology are: 3 H, 14 Ca, 32 P, 35 S, 38 Cl. Other radioisotopes contributing to studies on insects are: 198 Au, 134 Cs, 131 I, 86 Rb, 65 Zn, 59 Fe, 45 Ca, 24 Na, 22 Na. Radiation doses specific to each radioisotopes are given in tables. As an example of the application of radioisotopes in pest control: the determination of insects population density by means of releasing irradiated male insects than chasing them; studying of reproduction activity of Agrotis ipsilon; studying of egg laying of Heliocoverpa armigera moth. 15 refs. 2 figs. 2 tabs

  3. Application of radioisotopes in entomology

    Energy Technology Data Exchange (ETDEWEB)

    Saour, G [Atomic Energy Commission, Damascus (Syrian Arab Republic). Dept. of Radiation Agriculture

    1995-10-01

    Radioisotope techniques are effective in entomology and studies on insects physiology. The study presents the use of radioisotopes in pest control programs: Methods of insects irradiation and the concept of biological half-life of the radioisotopes in comparison with physical half-life are explained. Main radioisotopes used in entomology are:{sup 3}H, {sup 14}Ca, {sup 32}P, {sup 35}S, {sup 38}Cl. Other radioisotopes contributing to studies on insects are: {sup 198}Au, {sup 134}Cs, {sup 131}I, {sup 86}Rb, {sup 65}Zn, {sup 59}Fe, {sup 45}Ca, {sup 24}Na, {sup 22}Na. Radiation doses specific to each radioisotopes are given in tables. As an example of the application of radioisotopes in pest control: the determination of insects population density by means of releasing irradiated male insects than chasing them; studying of reproduction activity of Agrotis ipsilon; studying of egg laying of Heliocoverpa armigera moth. 15 refs. 2 figs. 2 tabs.

  4. Radioisotopes in industry

    International Nuclear Information System (INIS)

    Popple, B.N.

    1977-01-01

    The author explains clearly what is radiography, enumerates four major factors in considering a practical source to use namely half-life, penetrating power, half value layer and specific activity and also the advantages and disadvantages in using isotopes. Common radioisotopes used in industrial radiography are iridium, cesium, cobalt and thulium. Main uses of the radioisotopes are for radiographic testing like welding castings, forgoings etc.; thickness, level or density measurement and tracing. (RTD)

  5. Contribution to the study of radioisotopic methods in pharmacokinetics. Application to specific determinations of drugs or their metabolites

    International Nuclear Information System (INIS)

    Khiat, Mouloud.

    1977-01-01

    The aim of this work was to refute one of the major criticisms expressed on the used of labelled molecules, that they give an overall result. Techniques were therefore developed to determine quantitatively and specifically the kinetics of the drug itself or its metabolites. Two methods turning to account the great sensitivity and facility offered by labelled molecules have been adopted: - reverse isotopic dilution and double isotopic dilution, applied to some medicinal molecules. In part one the glipentide labelled molecule was used to measure the unchanged product in rat plasma: the kinetics are established. In part two the plasma fraction curves of unchanged products and their metabolites were studied for two molecules of similar structure: cyclobutane carboxylic acid and propyl-3 cyclobutane carboxylic acid. Finally a radiocompetitive method to determine a sulfamido-benzoic diuretic, based on the interaction with carbonic anhydrase, was investigated. The sensitivity of these radioisotopic methods depends on the specific activity of the labelled molecule. For the glipentide for instance, where the specific activity is very high, as little as 2 ng/ml of plasma can be determined. The specific activities of cyclobutane carboxylic, propyl-3 cyclobutane carboxylic and sulfamido-3 chloro-4 benzoic acids are not high enough for measurements better than 1 μg/ml plasma to be obtained [fr

  6. PET

    DEFF Research Database (Denmark)

    Mariager, Rasmus Mølgaard; Schmidt, Regin; Heiberg, Morten Rievers

    PET handler om den hemmelige tjenestes arbejde under den kolde krig 1945-1989. Her fortæller Regin Schmidt, Rasmus Mariager og Morten Heiberg om de mest dramatiske og interessante sager fra PET's arkiv. PET er på flere måder en udemokratisk institution, der er sat til at vogte over demokratiet....... Dens virksomhed er skjult for offentligheden, den overvåger borgernes aktiviteter, og den registrerer følsomme personoplysninger. Historien om PET rejser spørgsmålet om, hvad man skal gøre, når befolkningen i et demokrati er kritisk indstillet over for overvågningen af lovlige politiske aktiviteter......, mens myndighederne mener, at det er nødvendigt for at beskytte demokratiet. PET er på en gang en fortælling om konkrete aktioner og begivenheder i PET's arbejde og et stykke Danmarkshistorie. Det handler om overvågning, spioner, politisk ekstremisme og international terrorisme.  ...

  7. Sensitive, specific radioisotope assay for L-glutamine-D-fructose-6- phosphat aminotransferase

    International Nuclear Information System (INIS)

    Callahan, M.; Tourian, A.; Hung, W.Y.

    1981-01-01

    A sensitive and specific radioassay for L-glutamine-D-fructose-6-phosphate aminotransferase (EC 5.3.1.19) activity is presented. Picomoles of product are measurable, and the assay can be applied to systems having limited quantities of available protein, particularly in extracts of either cell or organ cultures. The assay is at least 10,000 times more sensitive under K 1 concentrations of fructose 6-phosphate than the modified Elson-Morgan colorimetric assay and 20 times more sensitive under saturating conditions of fructose 6-phosphate. As little as 0.5 μg of cell-extract protein will yield measurable product. In contrast, 280 μg of crude-extract protein from colon is required with the modified Elson-Morgan colorimetric assay

  8. New Innovations in Highly Ion Specific Media for Recalcitrant Waste stream Radioisotopes

    International Nuclear Information System (INIS)

    Denton, M. S.; Wilson, J.; Ahrendt, M.; Bostick, W. D.; DeSilva, F.; Meyers, P.

    2006-01-01

    Specialty ion specific media were examined and developed for, not only pre- and post-outage waste streams, but also for very difficult outage waste streams. This work was carried out on first surrogate waste streams, then laboratory samples of actual waste streams, and, finally, actual on-site waste streams. This study was particularly focused on PWR wastewaters such as Floor Drain Tank (FDT), Boron Waste Storage Tank (BWST), and Waste Treatment Tank (WTT, or discharge tank). Over the last half decade, or so, treatment technologies have so greatly improved and discharge levels have become so low, that certain particularly problematic isotopes, recalcitrant to current treatment skids, are all that remain prior to discharge. In reality, they have always been present, but overshadowed by the more prevalent and higher activity isotopes. Such recalcitrants include cobalt, especially Co 58 [both ionic/soluble (total dissolved solids, TDS) and colloidal (total suspended solids, TSS)] and antimony (Sb). The former is present in most FDT and BWST wastewaters, while the Sb is primarily present in BWST waste streams. The reasons Co 58 can be elusive to granulated activated carbon (GAC), ultrafiltration (UF) and ion exchange (IX) demineralizers is that it forms submicron colloids as well as has a tendency to form metal complexes with chelating agents (e.g., ethylene diamine tetraacetic acid, or EDTA). Such colloids and non-charged complexes will pass through the entire treatment skid. Antimony (Sb) on the other hand, has little or no ionic charge, and will, likewise, pass through both the filtration and de-min skids into the discharge tanks. While the latter will sometimes (the anionic vs. the cationic or neutral species) be removed on the anion bed(s), it will slough off (snow-plow effect) when a higher affinity anion (iodine slugs, etc.) comes along; thus causing effluents not meeting discharge criteria. The answer to these problems found in this study, during an actual

  9. Septa design for a prostate specific PET camera

    International Nuclear Information System (INIS)

    Qi, Jinyi; Huber, Jennifer S.; Huesman, Ronald H.; Moses, William W.; Derenzo, Stephen E.; Budinger, Thomas F.

    2003-01-01

    The recent development of new prostate tracers has motivated us to build a low cost PET camera optimized to image the prostate. Coincidence imaging of positron emitters is achieved using a pair of external curved detector banks. The bottom bank is fixed below the patient bed, and the top bank moves upward for patient access and downward for maximum sensitivity. In this paper, we study the design of septa for the prostate camera using Monte Carlo simulations. The system performance is measured by the detectability of a prostate lesion. We have studied 17 septa configurations. The results show that the design of septa has a large impact on the lesion detection at a given activity concentration. Significant differences are also observed between the lesion detectability and the conventional noise equivalent count (NEC) performance, indicating that the NEC is not appropriate for the detection task

  10. Radioisotopic indicators in microbiology

    International Nuclear Information System (INIS)

    Isamov, N.N.

    1976-01-01

    The book comprises data obtained by the laboratory of radiobiology (Uzbek Research Veterinary Institute) for 15 years and sums up data of domestic and foreign scientists; it discusses problems of the utilization of radioactive isotopes of sulphur, cadmium, phosphorus and other chemical elements by microorganisms; indicates the specificity of the utilization of radioisotopes in microbiology. The influence is considered of external factors on the inclusion of radioisotopes into microorganisms, methods are discussed of obtaining labelled microorganisms and their antigens, radioactivity of bacteria is considered as affected by the consistency and composition of the nutritive medium and other problems

  11. Radioisotope clocks in archaeology

    Energy Technology Data Exchange (ETDEWEB)

    Hedges, R E.M. [Oxford Univ. (UK). Research Lab. for Archaeology

    1979-09-06

    Methods of absolute dating which use the rate of disintegration of a radioactive nucleus as the clock, are reviewed. The use of the abundant radioisotopes (/sup 40/K, Th and U) and of the rare radioisotopes (/sup 14/C, /sup 10/Be, /sup 26/Al, /sup 32/Si, /sup 36/Cl, /sup 41/Ca, /sup 53/Mn) is discussed and radiation integration techniques (fission track dating, thermoluminescence and related techniques) are considered. Specific fields of use of the various methods and their accuracy are examined.

  12. Modular Stirling Radioisotope Generator

    Science.gov (United States)

    Schmitz, Paul C.; Mason, Lee S.; Schifer, Nicholas A.

    2016-01-01

    High-efficiency radioisotope power generators will play an important role in future NASA space exploration missions. Stirling Radioisotope Generators (SRGs) have been identified as a candidate generator technology capable of providing mission designers with an efficient, high-specific-power electrical generator. SRGs high conversion efficiency has the potential to extend the limited Pu-238 supply when compared with current Radioisotope Thermoelectric Generators (RTGs). Due to budgetary constraints, the Advanced Stirling Radioisotope Generator (ASRG) was canceled in the fall of 2013. Over the past year a joint study by NASA and the Department of Energy (DOE) called the Nuclear Power Assessment Study (NPAS) recommended that Stirling technologies continue to be explored. During the mission studies of the NPAS, spare SRGs were sometimes required to meet mission power system reliability requirements. This led to an additional mass penalty and increased isotope consumption levied on certain SRG-based missions. In an attempt to remove the spare power system, a new generator architecture is considered, which could increase the reliability of a Stirling generator and provide a more fault-tolerant power system. This new generator called the Modular Stirling Radioisotope Generator (MSRG) employs multiple parallel Stirling convertor/controller strings, all of which share the heat from the General Purpose Heat Source (GPHS) modules. For this design, generators utilizing one to eight GPHS modules were analyzed, which provided about 50 to 450 W of direct current (DC) to the spacecraft, respectively. Four Stirling convertors are arranged around each GPHS module resulting in from 4 to 32 Stirling/controller strings. The convertors are balanced either individually or in pairs, and are radiatively coupled to the GPHS modules. Heat is rejected through the housing/radiator, which is similar in construction to the ASRG. Mass and power analysis for these systems indicate that specific

  13. Isotope specific resolution recovery image reconstruction in high resolution PET imaging

    NARCIS (Netherlands)

    Kotasidis, Fotis A.; Angelis, Georgios I.; Anton-Rodriguez, Jose; Matthews, Julian C.; Reader, Andrew J.; Zaidi, Habib

    Purpose: Measuring and incorporating a scanner-specific point spread function (PSF) within image reconstruction has been shown to improve spatial resolution in PET. However, due to the short half-life of clinically used isotopes, other long-lived isotopes not used in clinical practice are used to

  14. Tailoring medium energy proton beam to induce low energy nuclear reactions in ⁸⁶SrCl₂ for production of PET radioisotope ⁸⁶Y.

    Science.gov (United States)

    Medvedev, Dmitri G; Mausner, Leonard F; Pile, Philip

    2015-07-01

    This paper reports results of experiments at Brookhaven Linac Isotope Producer (BLIP) aiming to investigate effective production of positron emitting radioisotope (86)Y by the low energy (86)Sr(p,n) reaction. BLIP is a facility at Brookhaven National Laboratory designed for the proton irradiation of the targets for isotope production at high and intermediate proton energies. The proton beam is delivered by the Linear Accelerator (LINAC) whose incident energy is tunable from 200 to 66 MeV in approximately 21 MeV increments. The array was designed to ensure energy degradation from 66 MeV down to less than 20 MeV. Aluminum slabs were used to degrade the proton energy down to the required range. The production yield of (86)Y (1.2+/-0.1 mCi (44.4+/-3.7) MBq/μAh) and ratio of radioisotopic impurities was determined by assaying an aliquot of the irradiated (86)SrCl2 solution by gamma spectroscopy. The analysis of energy dependence of the (86)Y production yield and the ratios of radioisotopic impurities has been used to adjust degrader thickness. Experimental data showed substantial discrepancies in actual energy propagation compared to energy loss calculations. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Specification and estimation of sources of bias affecting neurological studies in PET/MR with an anatomical brain phantom

    Energy Technology Data Exchange (ETDEWEB)

    Teuho, J., E-mail: jarmo.teuho@tyks.fi [Turku PET Centre, Turku (Finland); Johansson, J. [Turku PET Centre, Turku (Finland); Linden, J. [Turku PET Centre, Turku (Finland); Department of Mathematics and Statistics, University of Turku, Turku (Finland); Saunavaara, V.; Tolvanen, T.; Teräs, M. [Turku PET Centre, Turku (Finland)

    2014-01-11

    Selection of reconstruction parameters has an effect on the image quantification in PET, with an additional contribution from a scanner-specific attenuation correction method. For achieving comparable results in inter- and intra-center comparisons, any existing quantitative differences should be identified and compensated for. In this study, a comparison between PET, PET/CT and PET/MR is performed by using an anatomical brain phantom, to identify and measure the amount of bias caused due to differences in reconstruction and attenuation correction methods especially in PET/MR. Differences were estimated by using visual, qualitative and quantitative analysis. The qualitative analysis consisted of a line profile analysis for measuring the reproduction of anatomical structures and the contribution of the amount of iterations to image contrast. The quantitative analysis consisted of measurement and comparison of 10 anatomical VOIs, where the HRRT was considered as the reference. All scanners reproduced the main anatomical structures of the phantom adequately, although the image contrast on the PET/MR was inferior when using a default clinical brain protocol. Image contrast was improved by increasing the amount of iterations from 2 to 5 while using 33 subsets. Furthermore, a PET/MR-specific bias was detected, which resulted in underestimation of the activity values in anatomical structures closest to the skull, due to the MR-derived attenuation map that ignores the bone. Thus, further improvements for the PET/MR reconstruction and attenuation correction could be achieved by optimization of RAMLA-specific reconstruction parameters and implementation of bone to the attenuation template. -- Highlights: • Comparison between PET, PET/CT and PET/MR was performed with a novel brain phantom. • The performance of reconstruction and attenuation correction in PET/MR was studied. • A recently developed brain phantom was found feasible for PET/MR imaging. • Contrast reduction

  16. Radioisotope camera

    International Nuclear Information System (INIS)

    Tausch, L.M.; Kump, R.J.

    1978-01-01

    The electronic ciruit corrects distortions caused by the distance between the individual photomultiplier tubes of the multiple radioisotope camera on one hand and between the tube configuration and the scintillator plate on the other. For this purpose the transmission characteristics of the nonlinear circuits are altered as a function of the energy of the incident radiation. By this means the threshold values between lower and higher amplification are adjusted to the energy level of each scintillation. The correcting circuit may be used for any number of isotopes to be measured. (DG) [de

  17. Immuno PET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo

    DEFF Research Database (Denmark)

    Rolle, Anna-Maria; Hasenberg, Mike; Thornton, Christopher R.

    2016-01-01

    -infected mice allowed specific localization of lung infection when combined with PET. Optical imaging with a fluorochrome-labeled version of the mAb showed colocalization with invasive hyphae. The mAb-based newly developed PET tracer [64Cu]DOTA-JF5 distinguishedIPA from bacterial lung infections and...

  18. Specific activities and the relevant gamma ray dose rates at 1 meter from radioisotopes and isomers following thermal neutron capture reaction

    International Nuclear Information System (INIS)

    Eissa, E.A.; Aly, R.A.; Gomaa, M.A.; Hassan, A.M.

    1995-01-01

    Calculations were performed for the specific activity of 245 gamma-ray emitting radioisotopes and isomers produced in 48, 72 and 96 hour irradiation periods of the natural isotopic mixture of their 77 elements with thermal neutron flux 1.0 E + 13 n/cm 2 .5, at the core of the (ET-R R-1) reactor. The relevant gamma-ray dose rate at a point 1 meter apart from each radioisotope or isomer was evaluated whenever the specific gamma-ray dose rate constant is available. The irradiation time factor (ITF) for the irradiation periods 24, 48, 72 and 96 hours are reported for each of the 248 gamma-ray emitters. The average of (ITF) over these 248 radionuclides for each irradiation period is taken as a measure of the feasibility of the irradiation time. The results favour the increase of the irradiation period from the conventional 48 to 72 hours but not to 96 hours. A programme was established in the VAX computer to carry out the above mentioned calculations. Tables of the present work are very useful for isotope production and reactor safety. 1 fig., 2 tabs

  19. Acquiring additional delayed PET images improves sensitivity and specificity in oncology cases

    International Nuclear Information System (INIS)

    Lamki, L.M.; Barron, B.J.; Mullani, N.; Joseph, U.; Ehert, E.

    2002-01-01

    Aim: This study looked into utility of acquiring PET images at 2-3 hours in addition to the standard whole body PET done at 1-hour after FDG injection in certain oncology cases. The objective is to evaluate whether the delayed additional images can decipher equivocal foci of FDG accumulation commonly seen in oncology patients. Typical example is the bowel activity that moves with time. Materials and Methods: PET protocol at our Institution in patients with colon Cancer, Pancreas Ca, Ovarian Ca and Breast Ca include a whole body PET (6-7 bed positions) done at 1-hour after 15 mCi F-18-FDG followed by select limited area PET scan (typically 2 bed stops over the area of interest) at 2-3 hours. Acquisition was undertaken on Siemens ECAT-EXACT Camera - 2-D acquisition and 8 mins. per bed position (5 mins. Emission and 3 mins. Transmission), 16.3 cm FOV and then Iterative Reconstruction. Results: Analysis of the first 115 patients who had additional delayed images resulted in 80% of patients where delayed images helped in interpretation. In 70% of these, delayed images helped in identifying physiological structures, e.g., ureters, bowel, blood vessels and muscles versus pathology. In 25%, they actually helped in identifying malignancy, e.g. more definite FDG accumulation. Almost all helped to boost the confidence of the reader. The contribution was mainly in differentiating bowel and ureter activity from cancer in the abdomen, as these change position with time. In case of pancreas and breast cancer, delayed images contributed in clarifying tumor metabolic activity as well. Inflammation and motion artifacts could also be better defined and so was muscle uptake. Conclusion: (1) Additional delayed PET imaging is very helpful in certain cancers in identifying more lesions and avoiding pitfalls. (2) They can yield higher sensitivity and specificity for colon, ovarian, breast and pancreas cancers. (3) Identification of physiologic structures and differentiation of these from

  20. Isotope specific resolution recovery image reconstruction in high resolution PET imaging

    OpenAIRE

    Kotasidis Fotis A.; Kotasidis Fotis A.; Angelis Georgios I.; Anton-Rodriguez Jose; Matthews Julian C.; Reader Andrew J.; Reader Andrew J.; Zaidi Habib; Zaidi Habib; Zaidi Habib

    2014-01-01

    Purpose: Measuring and incorporating a scanner specific point spread function (PSF) within image reconstruction has been shown to improve spatial resolution in PET. However due to the short half life of clinically used isotopes other long lived isotopes not used in clinical practice are used to perform the PSF measurements. As such non optimal PSF models that do not correspond to those needed for the data to be reconstructed are used within resolution modeling (RM) image reconstruction usuall...

  1. A new PET tracer specific for vascular endothelial growth factor receptor

    International Nuclear Information System (INIS)

    Wang, Hui; Cai, Weibo; Chen, Kai; Li, Zi-Bo; Kashefi, Amir; He, Lina; Chen, Xiaoyuan

    2007-01-01

    Noninvasive positron emission tomography (PET) imaging of vascular endothelial growth factor receptor 2 (VEGFR-2) expression could be a valuable tool for evaluation of patients with a variety of malignancies, and particularly for monitoring those undergoing antiangiogenic therapies that block VEGF/VEGFR-2 function. The aim of this study was to develop a VEGFR-2-specific PET tracer. The D63AE64AE67A mutant of VEGF 121 (VEGF DEE ) was generated by recombinant DNA technology. VEGF 121 and VEGF DEE were purified and conjugated with DOTA for 64 Cu labeling. The DOTA conjugates were tested in vitro for VEGFR-2 specificity and functional activity. In vivo tumor targeting efficacy and pharmacokinetics of 64 Cu-labeled VEGF 121 and VEGF DEE were compared using an orthotopic 4T1 murine breast tumor model. Blocking experiments, biodistribution studies, and immunofluorescence staining were carried out to confirm the noninvasive imaging results. Cell binding assay demonstrated that VEGF DEE had about 20-fold lower VEGFR-1 binding affinity and only slightly lower VEGFR-2 binding affinity as compared with VEGF 121 . MicroPET imaging studies revealed that both 64 Cu-DOTA-VEGF 121 and 64 Cu-DOTA-VEGF DEE had rapid and prominent activity accumulation in VEGFR-2-expressing 4T1 tumors. The renal uptake of 64 Cu-DOTA-VEGF DEE was significantly lower than that of 64 Cu-DOTA-VEGF 121 as rodent kidneys expressed high levels of VEGFR-1 based on immunofluorescence staining. Blocking experiments and biodistribution studies confirmed the VEGFR specificity of 64 Cu-DOTA-VEGF DEE . We have developed a VEGFR-2-specific PET tracer, 64 Cu-DOTA-VEGF DEE . It has comparable tumor targeting efficacy to 64 Cu-DOTA-VEGF 121 but much reduced renal toxicity. This tracer may be translated into the clinic for imaging tumor angiogenesis and monitoring antiangiogenic treatment efficacy. (orig.)

  2. A useful PET probe [11C]BU99008 with ultra-high specific radioactivity for small animal PET imaging of I2-imidazoline receptors in the hypothalamus

    International Nuclear Information System (INIS)

    Kawamura, Kazunori; Shimoda, Yoko; Yui, Joji; Zhang, Yiding; Yamasaki, Tomoteru; Wakizaka, Hidekatsu; Hatori, Akiko; Xie, Lin; Kumata, Katsushi; Fujinaga, Masayuki; Ogawa, Masanao; Kurihara, Yusuke; Nengaki, Nobuki; Zhang, Ming-Rong

    2017-01-01

    Introduction: A positron emission tomography (PET) probe with ultra-high specific radioactivity (SA) enables measuring high receptor specific binding in brain regions by avoiding mass effect of the PET probe itself. It has been reported that PET probe with ultra-high SA can detect small change caused by endogenous or exogenous ligand. Recently, Kealey et al. developed [ 11 C]BU99008, a more potent PET probe for I 2 -imidazoline receptors (I 2 Rs) imaging, with a conventional SA (mean 76 GBq/μmol) showed higher specific binding in the brain. Here, to detect small change of specific binding for I 2 Rs caused by endogenous or exogenous ligand in an extremely small region, such as hypothalamus in the brain, we synthesized and evaluated [ 11 C]BU99008 with ultra-high SA as a useful PET probe for small-animal PET imaging of I 2 Rs. Methods: [ 11 C]BU99008 was prepared by [ 11 C]methylation of N-desmethyl precursor with [ 11 C]methyl iodide. Biodistribution, metabolite analysis, and brain PET studies were conducted in rats. Results: [ 11 C]BU99008 with ultra-high SA in the range of 5400–16,600 GBq/μmol were successfully synthesized (n = 7), and had appropriate radioactivity for in vivo study. In the biodistribution study, the mean radioactivity levels in all investigated tissues except for the kidney did not show significant difference between [ 11 C]BU99008 with ultra-high SA and that with conventional SA. In the metabolite analysis, the percentage of unchanged [ 11 C]BU99008 at 30 min after the injection of probes with ultra-high and conventional SA was similar in rat brain and plasma. In the PET study of rats' brain, radioactivity level (AUC 30–60 min ) in the hypothalamus of rats injected with [ 11 C]BU99008 with ultra-high SA (64 [SUV ∙ min]) was significantly higher than that observed for that with conventional SA (50 [SUV ∙ min]). The specific binding of [ 11 C]BU99008 with ultra-high SA (86% of total binding) for I 2 R was higher than that of

  3. Radioisotope production

    International Nuclear Information System (INIS)

    1988-01-01

    The trial production runs started in the previous report period were continued and have been extended to 67 Ga, 81 Rb/ 81m Kr and 111 In, the production of which will be taken over from the Pretoria cyclotron at the end of this year, when that machine is scheduled to be shut down. After commissioning of the target water cooling system and the helium cooling system for beam foil windows at the beginning of this year, these production runs could also be extended to high beam currents (up to 50 μA). Test consignments of a number of products have been supplied to various potential future users, and 123 I, in the form of Na 123 I capsules as well as 123 I-sodium hippurate, and 52 Fe-citrate have actually been used with success in trial diagnostic studies on patients. A procedure for labelling IPPA and 3-IPMPA with 123 I has been developed, while initial work has also been done on the radioiodination of monoclonal antifibrine antibodies. The last major facility needed for the commencement of the routine radioisotope production programme, namely the multiple-target facility, is now ready for installation in the production vault within the next few weeks, and routine production runs are expected to start in November 1988. 4 figs., 18 refs

  4. Radioisotope laboratory in Turkey

    International Nuclear Information System (INIS)

    1961-01-01

    The Turkish Government formally requested that the Agency provide for one year the services of an expert in the agricultural applications of radioisotopes. Specifically, they wanted this expert first of all to assist in setting up and equipping a pioneer laboratory for the utilization of radioisotopes in agricultural research. Once the laboratory was in operation, the expert was to initiate various research projects using isotope techniques, and to train personnel to carry on this work. The Agency was also asked to supply various specialized equipment for the laboratory, including some radioisotopes. On 10 December 1960 the first phase was complete - the new laboratory was formally opened. It is foreseen that the research projects which will be initiated at the laboratory will include the following: determination of the effect of fertilizers upon yield and quality of field crops and fruit trees, soil fertility studies, studies of mineral element uptake and localization of nutrients in plant body, studies of the folar application of mineral nutrients, especially in fruit trees, investigation of microelements in field crops and fruit trees, investigation of pollination problems, study of the distribution of mineral elements in different fruit seedlings, study of the uptake of nutrients by fruit trees during the rest period, dispersal studies on insects, insecticide studies

  5. Radioisotope laboratory in Turkey

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1961-04-15

    The Turkish Government formally requested that the Agency provide for one year the services of an expert in the agricultural applications of radioisotopes. Specifically, they wanted this expert first of all to assist in setting up and equipping a pioneer laboratory for the utilization of radioisotopes in agricultural research. Once the laboratory was in operation, the expert was to initiate various research projects using isotope techniques, and to train personnel to carry on this work. The Agency was also asked to supply various specialized equipment for the laboratory, including some radioisotopes. On 10 December 1960 the first phase was complete - the new laboratory was formally opened. It is foreseen that the research projects which will be initiated at the laboratory will include the following: determination of the effect of fertilizers upon yield and quality of field crops and fruit trees, soil fertility studies, studies of mineral element uptake and localization of nutrients in plant body, studies of the folar application of mineral nutrients, especially in fruit trees, investigation of microelements in field crops and fruit trees, investigation of pollination problems, study of the distribution of mineral elements in different fruit seedlings, study of the uptake of nutrients by fruit trees during the rest period, dispersal studies on insects, insecticide studies.

  6. Persistent non-specific FDG uptake on PET imaging following hip arthroplasty

    Energy Technology Data Exchange (ETDEWEB)

    Zhuang, Hongming; Chacko, Thomas K.; Hickeson, Marc; Stevenson, Karen; Feng, Qi; Ponzo, Fabio; Alavi, Abass [Division of Nuclear Medicine, Department of Radiology, The Hospital of University of Pennsylvania, 110 Donner Building, 3400 Spruce Street, Philadelphia, PA 19104 (United States); Garino, Jonathan P. [Department of Orthopedic Surgery, The Hospital of University of Pennsylvania, Philadelphia, PA 19802 (United States)

    2002-10-01

    prosthesis. The average time interval between arthroplasty and FDG-PET scan in these patients was 71.3 months. In only four prostheses (19%, 4 of 21) was no abnormally increased FDG uptake seen around the prostheses or adjacent sites. The average time interval in these patients was 114.8 months. It is concluded that following hip arthroplasty, non-specifically increased FDG uptake around the head or neck of the prosthesis persists for many years, even in patients without any complications. Therefore, to minimize the number of false-positive results for infection with PET studies obtained to evaluate a painful hip prosthesis, caution should be exercised when interpreting FDG uptake around the head or neck portion of the prosthesis. (orig.)

  7. Manual for reactor produced radioisotopes

    International Nuclear Information System (INIS)

    2003-01-01

    Radioisotopes find extensive applications in several fields including medicine, industry, agriculture and research. Radioisotope production to service different sectors of economic significance constitutes an important ongoing activity of many national nuclear programmes. Radioisotopes, formed by nuclear reactions on targets in a reactor or cyclotron, require further processing in almost all cases to obtain them in a form suitable for use. Specifications for final products and testing procedures for ensuring quality are also an essential part of a radioisotope production programme. The International Atomic Energy Agency (IAEA) has compiled and published such information before for the benefit of laboratories of Member States. The first compilation, entitled Manual of Radioisotope Production, was published in 1966 (Technical Reports Series No. 63). A more elaborate and comprehensive compilation, entitled Radioisotope Production and Quality Control, was published in 1971 (Technical Reports Series No. 128). Both served as useful reference sources for scientists working in radioisotope production worldwide. The 1971 publication has been out of print for quite some time. The IAEA convened a consultants meeting to consider the need for compiling an updated manual. The consultants recommended the publication of an updated manual taking the following into consideration: significant changes have taken place since 1971 in many aspects of radioisotope production; many radioisotopes have been newly introduced while many others have become gradually obsolete; considerable experience and knowledge have been gained in production of important radioisotopes over the years, which can be preserved through compilation of the manual; there is still a need for a comprehensive manual on radioisotope production methods for new entrants to the field, and as a reference. It was also felt that updating all the subjects covered in the 1971 manual at a time may not be practical considering the

  8. Radioisotope detection with accelerators

    International Nuclear Information System (INIS)

    Mast, T.S.; Muller, R.A.; Tans, P.P.

    1979-12-01

    High energy mass spectrometry is a new and very sensitive technique of measuring rare radioisotopes. This paper describes the techniques used to select and identify the individual radioisotope atoms in a sample and the status of the radioisotope measurements and their applications

  9. Specification and estimation of sources of bias affecting neurological studies in PET/MR with an anatomical brain phantom

    Science.gov (United States)

    Teuho, J.; Johansson, J.; Linden, J.; Saunavaara, V.; Tolvanen, T.; Teräs, M.

    2014-01-01

    Selection of reconstruction parameters has an effect on the image quantification in PET, with an additional contribution from a scanner-specific attenuation correction method. For achieving comparable results in inter- and intra-center comparisons, any existing quantitative differences should be identified and compensated for. In this study, a comparison between PET, PET/CT and PET/MR is performed by using an anatomical brain phantom, to identify and measure the amount of bias caused due to differences in reconstruction and attenuation correction methods especially in PET/MR. Differences were estimated by using visual, qualitative and quantitative analysis. The qualitative analysis consisted of a line profile analysis for measuring the reproduction of anatomical structures and the contribution of the amount of iterations to image contrast. The quantitative analysis consisted of measurement and comparison of 10 anatomical VOIs, where the HRRT was considered as the reference. All scanners reproduced the main anatomical structures of the phantom adequately, although the image contrast on the PET/MR was inferior when using a default clinical brain protocol. Image contrast was improved by increasing the amount of iterations from 2 to 5 while using 33 subsets. Furthermore, a PET/MR-specific bias was detected, which resulted in underestimation of the activity values in anatomical structures closest to the skull, due to the MR-derived attenuation map that ignores the bone. Thus, further improvements for the PET/MR reconstruction and attenuation correction could be achieved by optimization of RAMLA-specific reconstruction parameters and implementation of bone to the attenuation template.

  10. Complementary roles of tumour specific PET tracer {sup 18}F-FAMT to {sup 18}F-FDG PET/CT for the assessment of bone metastasis

    Energy Technology Data Exchange (ETDEWEB)

    Morita, Motoho [Gunma University Hospital, Department of General Medicine, Maebashi, Gunma (Japan); Gunma University Graduate School of Medicine, Department of Diagnostic Radiology and Nuclear Medicine, Maebashi, Gunma (Japan); Higuchi, Tetsuya; Tokue, Azusa; Arisaka, Yukiko; Tsushima, Yoshito [Gunma University Graduate School of Medicine, Department of Diagnostic Radiology and Nuclear Medicine, Maebashi, Gunma (Japan); Achmad, Arifudin [Gunma University Graduate School of Medicine, Department of Diagnostic Radiology and Nuclear Medicine, Maebashi, Gunma (Japan); Gadjah Mada University, Department of Radiology, Faculty of Medicine, Yogyakarta (Indonesia)

    2013-10-15

    The usefulness of {sup 18}F-FDG PET/CT for bone metastasis evaluation has already been established. The amino acid PET tracer [{sup 18}F]-3-fluoro-alpha-methyl tyrosine ({sup 18}F-FAMT) has been reported to be highly specific for malignancy. We evaluated the additional value of {sup 18}F-FAMT PET/CT to complement {sup 18}F-FDG PET/CT in the evaluation of bone metastasis. This retrospective study included 21 patients with bone metastases of various cancers who had undergone both {sup 18}F-FDG and {sup 18}F-FAMT PET/CT within 1 month of each other. {sup 18}F-FDG-avid bone lesions suspicious for malignancy were carefully selected based on the cut-off value for malignancy, and the SUVmax of the {sup 18}F-FAMT in the corresponding lesions were evaluated. A total of 72 {sup 18}F-FDG-positive bone lesions suspected to be metastases in the 21 patients were used as the reference standard. {sup 18}F-FAMT uptake was found in 87.5 % of the lesions. In the lesions of lung cancer origin, the uptake of the two tracers showed a good correlation (40 lesions, r = 0.68, P < 0.01). Bone metastatic lesions of oesophageal cancer showed the highest average of {sup 18}F-FAMT uptake. Bone metastatic lesions of squamous cell carcinoma showed higher {sup 18}F-FAMT uptake than those of adenocarcinoma. No significant difference in {sup 18}F-FAMT uptake was seen between osteoblastic and osteolytic bone metastatic lesions. The usefulness of {sup 18}F-FAMT PET/CT for bone metastasis detection regardless of the lesion phenotype was demonstrated. The fact that {sup 18}F-FAMT uptake was confirmed by {sup 18}F-FDG uptake suggests that {sup 18}F-FAMT PET/CT has the potential to complement {sup 18}F-FDG PET/CT for the detection of bone metastases. (orig.)

  11. Specific image characteristics influence attitudes about chimpanzee conservation and use as pets.

    Directory of Open Access Journals (Sweden)

    Stephen R Ross

    Full Text Available Chimpanzees are endangered in their native Africa but in the United States, they are housed not only in zoos and research centers but owned privately as pets and performers. In 2008, survey data revealed that the public is less likely to think that chimpanzees are endangered compared to other great apes, and that this is likely the result of media misportrayals in movies, television and advertisements. Here, we use an experimental survey paradigm with composite images of chimpanzees to determine the effects of specific image characteristics. We found that those viewing a photograph of a chimpanzee with a human standing nearby were 35.5% more likely to consider wild populations to be stable/healthy compared to those seeing the exact same picture without a human. Likewise, the presence of a human in the photograph increases the likelihood that they consider chimpanzees as appealing as a pet. We also found that respondents seeing images in which chimpanzees are shown in typically human settings (such as an office space were more likely to perceive wild populations as being stable and healthy compared to those seeing chimpanzees in other contexts. These findings shed light on the way that media portrayals of chimpanzees influence public attitudes about this important and endangered species.

  12. Specific image characteristics influence attitudes about chimpanzee conservation and use as pets.

    Science.gov (United States)

    Ross, Stephen R; Vreeman, Vivian M; Lonsdorf, Elizabeth V

    2011-01-01

    Chimpanzees are endangered in their native Africa but in the United States, they are housed not only in zoos and research centers but owned privately as pets and performers. In 2008, survey data revealed that the public is less likely to think that chimpanzees are endangered compared to other great apes, and that this is likely the result of media misportrayals in movies, television and advertisements. Here, we use an experimental survey paradigm with composite images of chimpanzees to determine the effects of specific image characteristics. We found that those viewing a photograph of a chimpanzee with a human standing nearby were 35.5% more likely to consider wild populations to be stable/healthy compared to those seeing the exact same picture without a human. Likewise, the presence of a human in the photograph increases the likelihood that they consider chimpanzees as appealing as a pet. We also found that respondents seeing images in which chimpanzees are shown in typically human settings (such as an office space) were more likely to perceive wild populations as being stable and healthy compared to those seeing chimpanzees in other contexts. These findings shed light on the way that media portrayals of chimpanzees influence public attitudes about this important and endangered species.

  13. Subject-specific bone attenuation correction for brain PET/MR: can ZTE-MRI substitute CT scan accurately?

    Science.gov (United States)

    Khalifé, Maya; Fernandez, Brice; Jaubert, Olivier; Soussan, Michael; Brulon, Vincent; Buvat, Irène; Comtat, Claude

    2017-10-01

    In brain PET/MR applications, accurate attenuation maps are required for accurate PET image quantification. An implemented attenuation correction (AC) method for brain imaging is the single-atlas approach that estimates an AC map from an averaged CT template. As an alternative, we propose to use a zero echo time (ZTE) pulse sequence to segment bone, air and soft tissue. A linear relationship between histogram normalized ZTE intensity and measured CT density in Hounsfield units (HU ) in bone has been established thanks to a CT-MR database of 16 patients. Continuous AC maps were computed based on the segmented ZTE by setting a fixed linear attenuation coefficient (LAC) to air and soft tissue and by using the linear relationship to generate continuous μ values for the bone. Additionally, for the purpose of comparison, four other AC maps were generated: a ZTE derived AC map with a fixed LAC for the bone, an AC map based on the single-atlas approach as provided by the PET/MR manufacturer, a soft-tissue only AC map and, finally, the CT derived attenuation map used as the gold standard (CTAC). All these AC maps were used with different levels of smoothing for PET image reconstruction with and without time-of-flight (TOF). The subject-specific AC map generated by combining ZTE-based segmentation and linear scaling of the normalized ZTE signal into HU was found to be a good substitute for the measured CTAC map in brain PET/MR when used with a Gaussian smoothing kernel of 4~mm corresponding to the PET scanner intrinsic resolution. As expected TOF reduces AC error regardless of the AC method. The continuous ZTE-AC performed better than the other alternative MR derived AC methods, reducing the quantification error between the MRAC corrected PET image and the reference CTAC corrected PET image.

  14. Site-specifically {sup 89}Zr-labeled monoclonal antibodies for ImmunoPET

    Energy Technology Data Exchange (ETDEWEB)

    Tinianow, Jeff N.; Gill, Herman S.; Ogasawara, Annie; Flores, Judith E.; Vanderbilt, Alexander N.; Luis, Elizabeth; Vandlen, Richard; Darwish, Martine; Junutula, Jagath R.; Williams, Simon-P. [Genentech Research and Early Development, Genentech Inc., South San Francisco, CA 94080 (United States); Marik, Jan [Genentech Research and Early Development, Genentech Inc., South San Francisco, CA 94080 (United States)], E-mail: marik.jan@gene.com

    2010-04-15

    Three thiol reactive reagents were developed for the chemoselective conjugation of desferrioxamine (Df) to a monoclonal antibody via engineered cysteine residues (thio-trastuzumab). The in vitro stability and in vivo imaging properties of site-specifically radiolabeled {sup 89}Zr-Df-thio-trastuzumab conjugates were investigated. Methods: The amino group of desferrioxamine B was acylated by bromoacetyl bromide, N-hydroxysuccinimidyl iodoacetate, or N-hydroxysuccinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate to obtain thiol reactive reagents bromoacetyl-desferrioxamine (Df-Bac), iodoacetyl-desferrioxamine (Df-Iac) and maleimidocyclohexyl-desferrioxamine (Df-Chx-Mal), respectively. Df-Bac and Df-Iac alkylated the free thiol groups of thio-trastuzumab by nucleophilic substitution forming Df-Ac-thio-trastuzumab, while the maleimide reagent Df-Chx-Mal reacted via Michael addition to provide Df-Chx-Mal-thio-trastuzumab. The conjugates were radiolabeled with {sup 89}Zr and evaluated for serum stability, and their positron emission tomography (PET) imaging properties were investigated in a BT474M1 (HER2-positive) breast tumor mouse model. Results: The chemoselective reagents were obtained in 14% (Df-Bac), 53% (Df-Iac) and 45% (Df-Chx-Mal) yields. Site-specific conjugation of Df-Chx-Mal to thio-trastuzumab was complete within 1 h at pH 7.5, while Df-Iac and Df-Bac respectively required 2 and 5 h at pH 9. Each Df modified thio-trastuzumab was chelated with {sup 89}Zr in yields exceeding 75%. {sup 89}Zr-Df-Ac-thio-trastuzumab and {sup 89}Zr-Df-Chx-Mal-thio-trastuzumab were stable in mouse serum and exhibited comparable PET imaging capabilities in a BT474M1 (HER2-positive) breast cancer model reaching 20-25 %ID/g of tumor uptake and a tumor to blood ratio of 6.1-7.1. Conclusions: The new reagents demonstrated good reactivity with engineered thiol groups of trastuzumab and very good chelation properties with {sup 89}Zr. The site-specifically {sup 89}Zr-labeled thio

  15. Radioisotope handling facilities and automation of radioisotope production

    International Nuclear Information System (INIS)

    2004-12-01

    If a survey is made of the advances in radioisotope handling facilities, as well as the technical conditions and equipment used for radioisotope production, it can be observed that no fundamental changes in the design principles and technical conditions of conventional manufacture have happened over the last several years. Recent developments are mainly based on previous experience aimed at providing safer and more reliable operations, more sophisticated maintenance technology and radioactive waste disposal. In addition to the above observation, significant improvements have been made in the production conditions of radioisotopes intended for medical use, by establishing aseptic conditions with clean areas and isolators, as well as by introducing quality assurance as governing principle in the production of pharmaceutical grade radioactive products. Requirements of the good manufacturing practice (GMP) are increasingly complied with by improving the technical and organizational conditions, as well as data registration and documentation. Technical conditions required for the aseptic production of pharmaceuticals and those required for radioactive materials conflicting in some aspects are because of the contrasting contamination mechanisms and due consideration of the radiation safety. These can be resolved by combining protection methods developed for pharmaceuticals and radioactive materials, with the necessary compromise in some cases. Automation serves to decrease the radiation dose to the operator and environment as well as to ensure more reliable and precise radiochemical processing. Automation has mainly been introduced in the production of sealed sources and PET radiopharmaceuticals. PC controlled technologies ensure high reliability for the production and product quality, whilst providing automatic data acquisition and registration required by quality assurance. PC control is also useful in the operation of measuring instruments and in devices used for

  16. Developments in radioisotope production and labelling of radiopharmaceuticals

    International Nuclear Information System (INIS)

    Lambrecht, R.M.

    1998-01-01

    Recent developments in both reactor and accelerator production of radioisotopes finding applications in nuclear medicine and in biomedical research are summarised. The priorities for the production of 48 different cyclotron radioisotopes; and for 42 reactor produced radioisotopes finding biomedical applications are identified. Each includes 5 generator systems. The rapid expansion of cyclotron based radioisotope production and automated synthesis of short-lived radiopharmaceuticals with the position-emitting radionuclides continues to gain momentum. Recent feasibility studies of the cyclotron production of 186 Re, 99m Tc and of 99 Mo are cited as examples of motivation to develop accelerator alternatives to use of nuclear reactors for medical radioisotope production. Examples of SPET and PET radiopharmaceuticals labelled with 131 I, 123 I, 124 I, 18 F, and with therapeutic radionuclides are highlighted. (author)

  17. Transport of radioisotopes

    International Nuclear Information System (INIS)

    Aoki, Shigefumi

    1978-01-01

    Presently the amount of radioisotopes increased very much and the application spread to wide fields in Japan. Since facilities using radioisotopes are distributed to every place in the country, every transport means such as airplanes, automobiles, railways, ships and mail are employed. The problems in the transport of radioisotopes include too much difference in the recognition of criticality among the persons concerning the transportation and treatment, knowledges of shielding and energy difference in the types of radiation and handling of sealed and unsealed sources and the casks for transport. IAEA established the latest regulation on the package of radioisotopes in 1973, and in Japan, the related regulations will be revised according to the IAEA's regulation in near future. The present status in the inspection at the time of shipment, supervision, and the measures to the accidents are described for the transport means of airplanes, ships and automobiles. Finally, concerning the insurance for cargo, the objects of the insurance for radioisotopes include either the radioisotopes contained in casks for transportation or radioisotopes only. Generally, radioisotopes are accepted in all-risk condition including casks and limited to the useful radioisotopes for peaceful use. (Wakatsuki, Y

  18. Advanced Radioisotope Power Systems Segmented Thermoelectric Research

    Science.gov (United States)

    Caillat, Thierry

    2004-01-01

    Flight times are long; - Need power systems with >15 years life. Mass is at an absolute premium; - Need power systems with high specific power and scalability. 3 orders of magnitude reduction in solar irradiance from Earth to Pluto. Nuclear power sources preferable. The Overall objective is to develop low mass, high efficiency, low-cost Advanced Radioisotope Power System with double the Specific Power and Efficiency over state-of-the-art Radioisotope Thermoelectric Generators (RTGs).

  19. Improvement of radioisotope production technology

    International Nuclear Information System (INIS)

    Li Yongjian

    1987-01-01

    The widespreading and deepgoing applications of radioisotopes results the increasing demands on both quality and quantity. This in turn stimulating the production technology to be improved unceasingly to meet the different requirements on availability, variety, facility, purity, specific activity and specificity. The major approaches of achieving these improvements including: optimizing mode of production; enhancing irradiation conditions; amelioration target arrangement; adapting nuclear process and inventing chemical processing. (author)

  20. Packaging and transport of radioisotopes

    International Nuclear Information System (INIS)

    Taylor, C.B.G.

    1976-01-01

    The importance of radioisotope traffic is emphasized. More than a million packages are being transported each year, mostly for medical uses. The involvement of public transport services and the incidental dose to the public (which is very small) are appreciably greater than for movements connected with the nuclear fuel cycle. Modern isotope packages are described, and an outline given of the problems of a large radioisotope manufacturer who has to package many different types of product. Difficulties caused by recent uncoordinated restrictions on the use of passenger aircraft are mentioned. Some specific problems relating to radioisotope packaging are discussed. These include the crush resistance of Type A packages, the closure of steel drums, the design of secure closures for large containers, the Type A packaging of liquids, leak tightness criteria of Type B packages, and the use of 'unit load' overpacks to consign a group of individually approved packages together as a single shipment. Reference is made to recent studies of the impact of radioisotope shipments on the environment. Cost/benefit analysis is important in this field - an important public debate is only just beginning. (author)

  1. Prostate-specific membrane antigen PET/MRI validation of MR textural analysis for detection of transition zone prostate cancer.

    Science.gov (United States)

    Bates, Anthony; Miles, Kenneth

    2017-12-01

    To validate MR textural analysis (MRTA) for detection of transition zone (TZ) prostate cancer through comparison with co-registered prostate-specific membrane antigen (PSMA) PET-MR. Retrospective analysis was performed for 30 men who underwent simultaneous PSMA PET-MR imaging for staging of prostate cancer. Thirty texture features were derived from each manually contoured T2-weighted, transaxial, prostatic TZ using texture analysis software that applies a spatial band-pass filter and quantifies texture through histogram analysis. Texture features of the TZ were compared to PSMA expression on the corresponding PET images. The Benjamini-Hochberg correction controlled the false discovery rate at prostate cancer. • Prostate transition zone (TZ) MR texture analysis may assist in prostate cancer detection. • Abnormal transition zone PSMA expression correlates with altered texture on T2-weighted MR. • TZ with abnormal PSMA expression demonstrates significantly reduced MI, SD and MPP.

  2. Radioisotope conveyor ash meter

    International Nuclear Information System (INIS)

    Savelov, V.D.

    1994-01-01

    Radioisotope conveyor ash meter realizes persistent measuring of ashiness of coal and products of its enrichment on the belt conveyor without contact. The principle of ash meter acting is based on functional dependence of the gamma radiation flows backscattering intensity of radioisotope sources from the ash volume content in the controlled fuel. Facility consists from the ashiness transducer and the processing and control device

  3. Production of radioisotopes with BR2 facilities

    International Nuclear Information System (INIS)

    Fallais, C.J.; Morel de Westfaver, A.; Heeren, L.; Baugnet, J.M.; Gandolfo, J.M.; Boeykens, W.

    1978-01-01

    After a brief account on the isotopes production evolution in the industrialized countries the irradiation devices and the types of standardized capsules used in the BR2 reactor are described as well as the thermal neutron flux. Production of most important radioisotopes like 131 Iodine, 60 Cobalt, 192 Iridium and 99 Molybdenum and their main utilizations (uses)are described. The mean specific activities and the limit of use for different radioisotopes are reported. (A.F.)

  4. Can FDG PET predict verbal specific memory decline after surgery for left temporal lobe epilepsy when MRI is normal?

    International Nuclear Information System (INIS)

    Sagona, J.A.; Rowe, C.C.; Thomas, D.; Dickinson-Rowe, K.L.

    2002-01-01

    Full text: Temporal lobectomy gives excellent control of seizures in over 80% of patients with temporal lobe epilepsy. The left temporal lobe, particularly the left hippocampus, is primarily responsible for verbal memory. In most patients, the hippocampus which lies in the medial temporal lobe is abnormal and can be removed without loss of memory function. However, removal of the left hippocampus when it appears normal on MRI, often causes a significant decline in verbal specific memory (VSM) function. This paper explores the significance of pre-operative FDG-PET asymmetry in temporal lobe metabolism in predicting the VSM outcome after left temporal lobectomy when MRI demonstrates a normal hippocampus. Fifteen patients between 1993 and 2000, underwent left temporal lobectomy including left hippocampal resection, Pre-operatively all patients underwent 1.5T MRI, FDG PET and neuropsychological assessment. Neuropsychological assessment was repeated post-operatively. The left hippocampus was normal on MRI in nine and demonstrated mild T2 signal change without atrophy in six. FDG PET demonstrated temporal lobe hypometabolism in 12 patients. Post-operatively, neuropsychological evaluation documented a decline in verbal specific memory function in six patients, three with normal MRI and three with mild T2 change. We found that all patients with normal FDG PET studies (n=3) demonstrated significant verbal memory deterioration post-operatively. Nine of twelve patients (75%) with left temporal lobe hypometabolism did not show new verbal memory deficits. FDG PET improves the risk stratification for verbal specific memory decline with left temporal lobectomy in patients with normal hippocampi on MRI. Copyright (2002) The Australian and New Zealand Society of Nuclear Medicine Inc

  5. Prostate-Specific Antigen and Prostate-Specific Antigen Velocity as Threshold Indicators in 11C-Acetate PET/CTAC Scanning for Prostate Cancer Recurrence

    Science.gov (United States)

    Dusing, Reginald W.; Peng, Warner; Lai, Sue-Min; Grado, Gordon L.; Holzbeierlein, Jeffrey M.; Thrasher, J. Brantley; Hill, Jacqueline; Van Veldhuizen, Peter J.

    2014-01-01

    Purpose The aim of this study was to identify which patient characteristics are associated with the highest likelihood of positive findings on 11C-acetate PET/computed tomography attenuation correction (CTAC) (PET/CTAC) scan when imaging for recurrent prostate cancer. Methods From 2007 to 2011, 250 11C-acetate PET/CTAC scans were performed at a single institution on patients with prostate cancer recurrence after surgery, brachytherapy, or external beam radiation. Of these patients, 120 met our inclusion criteria. Logistic regression analysis was used to examine the relationship between predictability of positive findings and patients’ characteristics, such as prostate-specific antigen (PSA) level at the time of scan, PSA kinetics, Gleason score, staging, and type of treatment before scan. Results In total, 68.3% of the 120 11C-acetate PET/CTAC scans were positive. The percentage of positive scans and PSA at the time of scanning and PSA velocity (PSAV) had positive correlations. The putative sensitivity and specificity were 86.6% and 65.8%, respectively, when a PSA level greater than 1.24 ng/mL was used as the threshold for scanning. The putative sensitivity and specificity were 74% and 75%, respectively, when a PSAV level greater than 1.32 ng/mL/y was used as the threshold. No significant associations were found between scan positivity and age, PSA doubling time, Gleason score, staging, or type of treatment before scanning. Conclusions This retrospective study suggests that threshold models of PSA greater than 1.24 ng/mL or PSAV greater than 1.32 ng/mL per year are independent predictors of positive findings in 11C-acetate PET/CTAC imaging of recurrent prostate cancer. PMID:25036021

  6. Isotope specific resolution recovery image reconstruction in high resolution PET imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kotasidis, Fotis A. [Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH-1211 Geneva, Switzerland and Wolfson Molecular Imaging Centre, MAHSC, University of Manchester, M20 3LJ, Manchester (United Kingdom); Angelis, Georgios I. [Faculty of Health Sciences, Brain and Mind Research Institute, University of Sydney, NSW 2006, Sydney (Australia); Anton-Rodriguez, Jose; Matthews, Julian C. [Wolfson Molecular Imaging Centre, MAHSC, University of Manchester, Manchester M20 3LJ (United Kingdom); Reader, Andrew J. [Montreal Neurological Institute, McGill University, Montreal QC H3A 2B4, Canada and Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering, King' s College London, St. Thomas’ Hospital, London SE1 7EH (United Kingdom); Zaidi, Habib [Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH-1211 Geneva (Switzerland); Geneva Neuroscience Centre, Geneva University, CH-1205 Geneva (Switzerland); Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, PO Box 30 001, Groningen 9700 RB (Netherlands)

    2014-05-15

    Purpose: Measuring and incorporating a scanner-specific point spread function (PSF) within image reconstruction has been shown to improve spatial resolution in PET. However, due to the short half-life of clinically used isotopes, other long-lived isotopes not used in clinical practice are used to perform the PSF measurements. As such, non-optimal PSF models that do not correspond to those needed for the data to be reconstructed are used within resolution modeling (RM) image reconstruction, usually underestimating the true PSF owing to the difference in positron range. In high resolution brain and preclinical imaging, this effect is of particular importance since the PSFs become more positron range limited and isotope-specific PSFs can help maximize the performance benefit from using resolution recovery image reconstruction algorithms. Methods: In this work, the authors used a printing technique to simultaneously measure multiple point sources on the High Resolution Research Tomograph (HRRT), and the authors demonstrated the feasibility of deriving isotope-dependent system matrices from fluorine-18 and carbon-11 point sources. Furthermore, the authors evaluated the impact of incorporating them within RM image reconstruction, using carbon-11 phantom and clinical datasets on the HRRT. Results: The results obtained using these two isotopes illustrate that even small differences in positron range can result in different PSF maps, leading to further improvements in contrast recovery when used in image reconstruction. The difference is more pronounced in the centre of the field-of-view where the full width at half maximum (FWHM) from the positron range has a larger contribution to the overall FWHM compared to the edge where the parallax error dominates the overall FWHM. Conclusions: Based on the proposed methodology, measured isotope-specific and spatially variant PSFs can be reliably derived and used for improved spatial resolution and variance performance in resolution

  7. Isotope specific resolution recovery image reconstruction in high resolution PET imaging

    International Nuclear Information System (INIS)

    Kotasidis, Fotis A.; Angelis, Georgios I.; Anton-Rodriguez, Jose; Matthews, Julian C.; Reader, Andrew J.; Zaidi, Habib

    2014-01-01

    Purpose: Measuring and incorporating a scanner-specific point spread function (PSF) within image reconstruction has been shown to improve spatial resolution in PET. However, due to the short half-life of clinically used isotopes, other long-lived isotopes not used in clinical practice are used to perform the PSF measurements. As such, non-optimal PSF models that do not correspond to those needed for the data to be reconstructed are used within resolution modeling (RM) image reconstruction, usually underestimating the true PSF owing to the difference in positron range. In high resolution brain and preclinical imaging, this effect is of particular importance since the PSFs become more positron range limited and isotope-specific PSFs can help maximize the performance benefit from using resolution recovery image reconstruction algorithms. Methods: In this work, the authors used a printing technique to simultaneously measure multiple point sources on the High Resolution Research Tomograph (HRRT), and the authors demonstrated the feasibility of deriving isotope-dependent system matrices from fluorine-18 and carbon-11 point sources. Furthermore, the authors evaluated the impact of incorporating them within RM image reconstruction, using carbon-11 phantom and clinical datasets on the HRRT. Results: The results obtained using these two isotopes illustrate that even small differences in positron range can result in different PSF maps, leading to further improvements in contrast recovery when used in image reconstruction. The difference is more pronounced in the centre of the field-of-view where the full width at half maximum (FWHM) from the positron range has a larger contribution to the overall FWHM compared to the edge where the parallax error dominates the overall FWHM. Conclusions: Based on the proposed methodology, measured isotope-specific and spatially variant PSFs can be reliably derived and used for improved spatial resolution and variance performance in resolution

  8. Isotope specific resolution recovery image reconstruction in high resolution PET imaging.

    Science.gov (United States)

    Kotasidis, Fotis A; Angelis, Georgios I; Anton-Rodriguez, Jose; Matthews, Julian C; Reader, Andrew J; Zaidi, Habib

    2014-05-01

    Measuring and incorporating a scanner-specific point spread function (PSF) within image reconstruction has been shown to improve spatial resolution in PET. However, due to the short half-life of clinically used isotopes, other long-lived isotopes not used in clinical practice are used to perform the PSF measurements. As such, non-optimal PSF models that do not correspond to those needed for the data to be reconstructed are used within resolution modeling (RM) image reconstruction, usually underestimating the true PSF owing to the difference in positron range. In high resolution brain and preclinical imaging, this effect is of particular importance since the PSFs become more positron range limited and isotope-specific PSFs can help maximize the performance benefit from using resolution recovery image reconstruction algorithms. In this work, the authors used a printing technique to simultaneously measure multiple point sources on the High Resolution Research Tomograph (HRRT), and the authors demonstrated the feasibility of deriving isotope-dependent system matrices from fluorine-18 and carbon-11 point sources. Furthermore, the authors evaluated the impact of incorporating them within RM image reconstruction, using carbon-11 phantom and clinical datasets on the HRRT. The results obtained using these two isotopes illustrate that even small differences in positron range can result in different PSF maps, leading to further improvements in contrast recovery when used in image reconstruction. The difference is more pronounced in the centre of the field-of-view where the full width at half maximum (FWHM) from the positron range has a larger contribution to the overall FWHM compared to the edge where the parallax error dominates the overall FWHM. Based on the proposed methodology, measured isotope-specific and spatially variant PSFs can be reliably derived and used for improved spatial resolution and variance performance in resolution recovery image reconstruction. The

  9. Site specific measurements of bone formation using [18F] sodium fluoride PET/CT.

    Science.gov (United States)

    Blake, Glen M; Puri, Tanuj; Siddique, Musib; Frost, Michelle L; Moore, Amelia E B; Fogelman, Ignac

    2018-02-01

    Dynamic positron emission tomography (PET) imaging with fluorine-18 labelled sodium fluoride ([ 18 F]NaF) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. Today, hybrid PET and computed tomography (CT) dual-modality systems (PET/CT) are widely available, and [ 18 F]NaF PET/CT offers a convenient non-invasive method of studying bone formation at the important osteoporotic fracture sites at the hip and spine, as well as sites of pure cortical or trabecular bone. The technique complements conventional measurements of bone turnover using biochemical markers or bone biopsy as a tool to investigate new therapies for osteoporosis, and has a potential role as an early biomarker of treatment efficacy in clinical trials. This article reviews methods of acquiring and analyzing dynamic [ 18 F]NaF PET/CT scan data, and outlines a simplified approach combining venous blood sampling with a series of short (3- to 5-minute) static PET/CT scans acquired at different bed positions to estimate [ 18 F]NaF plasma clearance at multiple sites in the skeleton with just a single injection of tracer.

  10. Radioisotope measurement system

    International Nuclear Information System (INIS)

    Villanueva Ruibal, Jose

    2007-01-01

    A radioisotope measurement system installed at L.M.R. (Ezeiza Atomic Center of CNEA) allows the measurement of nuclear activity from a wide range of radioisotopes. It permits to characterize a broad range of radioisotopes at several activity levels. The measurement hardware as well as the driving software have been developed and constructed at the Dept. of Instrumentation and Control. The work outlines the system's conformation and its operating concept, describes design characteristics, construction and the error treatment, comments assay results and supplies use advices. Measuring tests carried out employing different radionuclides confirmed the system performing satisfactorily and with friendly operation. (author) [es

  11. Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging

    Energy Technology Data Exchange (ETDEWEB)

    Sheikhbahaei, Sara; Solnes, Lilja B.; Javadi, Mehrbod S.; Pomper, Martin G.; Rowe, Steven P. [Johns Hopkins University School of Medicine, Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Afshar-Oromieh, Ali; Haberkorn, Uwe [Heidelberg University Hospital, Department of Nuclear Medicine, Heidelberg (Germany); Eiber, Matthias [David Geffen School of Medicine at UCLA, Department of Molecular and Medical Pharmacology, Los Angeles, CA (United States); Technical University of Munich, Department of Nuclear Medicine, Klinikum rechts der Isar, Munich (Germany); Ross, Ashley E.; Pienta, Kenneth J.; Allaf, Mohamad E.; Gorin, Michael A. [Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute and Department of Urology, Baltimore, MD (United States)

    2017-11-15

    The rapidly expanding clinical adaptation of prostate-specific membrane antigen (PSMA)-targeted PET imaging in the evaluation of patients with prostate cancer has placed an increasing onus on understanding both the potential pearls of interpretation as well as limitations of this new technique. As with any new molecular imaging modality, accurate characterization of abnormalities on PSMA-targeted PET imaging can be accomplished only if one is aware of the normal distribution pattern, physiological variants of radiotracer uptake, and potential sources of false-positive and false-negative imaging findings. In recent years, a growing number of reports have come to light describing incidental non-prostatic benign or malignant pathologies with high uptake on PSMA-targeted PET imaging. In this review, we have summarized the published literature regarding the potential pearls and technical and interpretive pitfalls of this imaging modality. Knowledge of these limitations can increase the confidence of interpreting physicians and thus improve patient care. As PSMA-targeted PET is expected to be evaluated in larger prospective trials, the dissemination of potential diagnostic pitfalls and the biologic underpinning of those findings will be of increased importance. (orig.)

  12. Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging

    International Nuclear Information System (INIS)

    Sheikhbahaei, Sara; Solnes, Lilja B.; Javadi, Mehrbod S.; Pomper, Martin G.; Rowe, Steven P.; Afshar-Oromieh, Ali; Haberkorn, Uwe; Eiber, Matthias; Ross, Ashley E.; Pienta, Kenneth J.; Allaf, Mohamad E.; Gorin, Michael A.

    2017-01-01

    The rapidly expanding clinical adaptation of prostate-specific membrane antigen (PSMA)-targeted PET imaging in the evaluation of patients with prostate cancer has placed an increasing onus on understanding both the potential pearls of interpretation as well as limitations of this new technique. As with any new molecular imaging modality, accurate characterization of abnormalities on PSMA-targeted PET imaging can be accomplished only if one is aware of the normal distribution pattern, physiological variants of radiotracer uptake, and potential sources of false-positive and false-negative imaging findings. In recent years, a growing number of reports have come to light describing incidental non-prostatic benign or malignant pathologies with high uptake on PSMA-targeted PET imaging. In this review, we have summarized the published literature regarding the potential pearls and technical and interpretive pitfalls of this imaging modality. Knowledge of these limitations can increase the confidence of interpreting physicians and thus improve patient care. As PSMA-targeted PET is expected to be evaluated in larger prospective trials, the dissemination of potential diagnostic pitfalls and the biologic underpinning of those findings will be of increased importance. (orig.)

  13. Prostate-specific membrane antigen PET/MRI validation of MR textural analysis for detection of transition zone prostate cancer

    International Nuclear Information System (INIS)

    Bates, Anthony; Miles, Kenneth

    2017-01-01

    To validate MR textural analysis (MRTA) for detection of transition zone (TZ) prostate cancer through comparison with co-registered prostate-specific membrane antigen (PSMA) PET-MR. Retrospective analysis was performed for 30 men who underwent simultaneous PSMA PET-MR imaging for staging of prostate cancer. Thirty texture features were derived from each manually contoured T2-weighted, transaxial, prostatic TZ using texture analysis software that applies a spatial band-pass filter and quantifies texture through histogram analysis. Texture features of the TZ were compared to PSMA expression on the corresponding PET images. The Benjamini-Hochberg correction controlled the false discovery rate at <5%. Eighty-eight T2-weighted images in 18 patients demonstrated abnormal PSMA expression within the TZ on PET-MR. 123 images were PSMA negative. Based on the corrected p-value of 0.005, significant differences between PSMA positive and negative slices were found for 16 texture parameters: Standard deviation and mean of positive pixels for all spatial filters (p = <0.0001 for both at all spatial scaling factor (SSF) values) and mean intensity following filtration for SSF 3-6 mm (p = 0.0002-0.0018). Abnormal expression of PSMA within the TZ is associated with altered texture on T2-weighted MR, providing validation of MRTA for the detection of TZ prostate cancer. (orig.)

  14. Prostate-specific membrane antigen PET/MRI validation of MR textural analysis for detection of transition zone prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Bates, Anthony [Princess Alexandra Hospital, Brisbane (Australia); Miles, Kenneth [Princess Alexandra Hospital, Department of Diagnostic Radiology, Brisbane, QLD (Australia); University College London, Institute of Nuclear Medicine, London (United Kingdom)

    2017-12-15

    To validate MR textural analysis (MRTA) for detection of transition zone (TZ) prostate cancer through comparison with co-registered prostate-specific membrane antigen (PSMA) PET-MR. Retrospective analysis was performed for 30 men who underwent simultaneous PSMA PET-MR imaging for staging of prostate cancer. Thirty texture features were derived from each manually contoured T2-weighted, transaxial, prostatic TZ using texture analysis software that applies a spatial band-pass filter and quantifies texture through histogram analysis. Texture features of the TZ were compared to PSMA expression on the corresponding PET images. The Benjamini-Hochberg correction controlled the false discovery rate at <5%. Eighty-eight T2-weighted images in 18 patients demonstrated abnormal PSMA expression within the TZ on PET-MR. 123 images were PSMA negative. Based on the corrected p-value of 0.005, significant differences between PSMA positive and negative slices were found for 16 texture parameters: Standard deviation and mean of positive pixels for all spatial filters (p = <0.0001 for both at all spatial scaling factor (SSF) values) and mean intensity following filtration for SSF 3-6 mm (p = 0.0002-0.0018). Abnormal expression of PSMA within the TZ is associated with altered texture on T2-weighted MR, providing validation of MRTA for the detection of TZ prostate cancer. (orig.)

  15. Prostate-specific membrane antigen PET imaging and immunohistochemistry in adenoid cystic carcinoma-@]@a preliminary analysis

    Energy Technology Data Exchange (ETDEWEB)

    Klein Nulent, Thomas J.W.; Es, Robert J.J. van [Utrecht Cancer Center, University Medical Center Utrecht, Department of Head and Neck Surgical Oncology, P.O. Box 85500, Utrecht (Netherlands); University Medical Center Utrecht, Department of Oral and Maxillofacial Surgery, Utrecht (Netherlands); Krijger, Gerard C.; Keizer, Bart de [University Medical Center Utrecht, Department of Radiology and Nuclear Medicine, Utrecht (Netherlands); Bree, Remco de [Utrecht Cancer Center, University Medical Center Utrecht, Department of Head and Neck Surgical Oncology, P.O. Box 85500, Utrecht (Netherlands); Willems, Stefan M. [University Medical Center Utrecht, Department of Pathology, Utrecht (Netherlands)

    2017-09-15

    Adenoid cystic carcinoma (AdCC) of the head and neck is an uncommon malignant epithelial tumour of the secretory glands. Many patients develop slowly growing local recurrence and/or distant metastasis, for which treatment options are limited. A retrospective analysis of 9 AdCC patients was conducted to analyse the visualization of AdCC on PSMA PET/CT and to investigate the expression of PSMA on primary, recurrent and metastatic AdCC tumour tissue using immunohistochemistry. Local recurrence occurred in six patients and eight developed distant metastasis. All PET/CTs depicted PSMA-ligand uptake. Four PSMA PET/CTs showed suspected residual disease, eight scans depicted uptake in areas suspected of distant metastasis. Median Maximum Standardized Uptake Value (SUV{sub max}) in local recurrent and distant metastatic AdCC was 2.52 (IQR 2.41-5.95) and 4.01 (IQR 2.66-8.71), respectively. All primary tumours showed PSMA expression on immunohistochemistry (5-90% expression), as well as all available specimens of local recurrence and distant metastases. PSMA PET/CT is able to detect and visualize local recurrent and distant metastatic AdCC. PSMA-specific targeting is supported by PSMA expression on immunohistochemistry. (orig.)

  16. Production and utilization of radioisotopes

    International Nuclear Information System (INIS)

    Sekine, Toshiaki; Matsuoka, Hiromitsu

    1999-01-01

    A plan of developing radioisotopes with a high power proton accelerator of the Neutron Science Project is presented. The status of production and utilization of radioisotopes in Japan is briefly discussed. The radioisotopes to be produced for biomedical use are discussed together with the facility for production of those radioisotopes and for research with the products. (author)

  17. Economical Radioisotope Power

    Data.gov (United States)

    National Aeronautics and Space Administration — Almost all robotic space exploration missions and all Apollo missions to the moon used Radioisotopic Thermoelectric Generators (RTGs) to provide electrical power to...

  18. Radionuclide production for PET with a linear electrostatic accelerator

    International Nuclear Information System (INIS)

    Shefer, R.E.; Hughey, B.J.; Klinkowstein, R.E.; Welch, M.J.

    1993-01-01

    A new type of linear electrostatic accelerator for the production of short-lived radionuclides for PET has been developed at Science Research Laboratory. The tandem cascade accelerator (TCA) is a low energy (3.7 MeV) proton and deuteron accelerator which can generate the four short-lived PET radionuclides in the quantities required for clinical use. The compact size, low weight, low power consumption and reduced radiation shielding requirements of the TCA result in a significant reduction in capital and operating costs when compared with higher energy cyclotron-based systems. Radioisotope target for the production of O-15, F-18, N-13 and C-11 have been designed specifically for use with the low energy TCA beam. A simple to use PC-based computer control system allows fully automated system operation and advanced scheduling of isotope production. Operating experience with the TCA and its PET radionuclide targets is described

  19. Radioisotope Sources of Electric Power

    Science.gov (United States)

    1973-09-20

    u) watt/cm-3 O) specific activity f) curia/watt (curie/a) a) half-life c) specific power output h) years (capacity) 1) days d) watt/p Polonium - 210 ...AD/A-001 210 RADIOISOTOPE SOURCES OF ELECTRIC POWER G. M. Fradkin, et al Army Foreign Science and Technology Center Charlottesville, Virginia 20...narticularlv for nurninn and irocess~ino of wastg.Sheatinc food , conversion of liruld oxtoner to des, and also for removal of imnurities and reula:tion

  20. Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET

    Energy Technology Data Exchange (ETDEWEB)

    Faellmar, David; Larsson, Elna-Marie [Uppsala University, Department of Surgical Sciences, Radiology, Uppsala (Sweden); Haller, Sven [Uppsala University, Department of Surgical Sciences, Radiology, Uppsala (Sweden); University Medical Center Freiburg, Department of Neuroradiology, Freiburg (Germany); University of Geneva, Faculty of Medicine, Geneva (Switzerland); Affidea CDRC - Centre Diagnostique Radiologique de Carouge, Carouge (Switzerland); Lilja, Johan [Uppsala University, Department of Surgical Sciences, Nuclear Medicine and PET, Uppsala (Sweden); Hermes Medical Solutions, Stockholm (Sweden); Danfors, Torsten [Uppsala University, Department of Surgical Sciences, Nuclear Medicine and PET, Uppsala (Sweden); Kilander, Lena [Uppsala University, Department of Public Health and Caring Sciences, Geriatrics, Uppsala (Sweden); Tolboom, Nelleke; Croon, Philip M.; Berckel, Bart N.M. van [VU University Medical Center, Department of Radiology and Nuclear Medicine, Amsterdam (Netherlands); Egger, Karl [University Medical Center Freiburg, Department of Neuroradiology, Freiburg (Germany); Kellner, Elias [Medical Center University of Freiburg, Department of Radiology, Medical Physics, Faculty of Medicine, Freiburg (Germany); Verfaillie, Sander C.J.; Ossenkoppele, Rik [VU University Medical Center, Department of Neurology, Alzheimer Center Amsterdam, Amsterdam (Netherlands); Barkhof, Frederik [VU University Medical Center, Department of Radiology and Nuclear Medicine, Amsterdam (Netherlands); UCL, Institutes of Neurology and Healthcare Engineering, London (United Kingdom)

    2017-10-15

    Cerebral perfusion analysis based on arterial spin labeling (ASL) MRI has been proposed as an alternative to FDG-PET in patients with neurodegenerative disease. Z-maps show normal distribution values relating an image to a database of controls. They are routinely used for FDG-PET to demonstrate disease-specific patterns of hypometabolism at the individual level. This study aimed to compare the performance of Z-maps based on ASL to FDG-PET. Data were combined from two separate sites, each cohort consisting of patients with Alzheimer's disease (n = 18 + 7), frontotemporal dementia (n = 12 + 8) and controls (n = 9 + 29). Subjects underwent pseudocontinuous ASL and FDG-PET. Z-maps were created for each subject and modality. Four experienced physicians visually assessed the 166 Z-maps in random order, blinded to modality and diagnosis. Discrimination of patients versus controls using ASL-based Z-maps yielded high specificity (84%) and positive predictive value (80%), but significantly lower sensitivity compared to FDG-PET-based Z-maps (53% vs. 96%, p < 0.001). Among true-positive cases, correct diagnoses were made in 76% (ASL) and 84% (FDG-PET) (p = 0.168). ASL-based Z-maps can be used for visual assessment of neurodegenerative dementia with high specificity and positive predictive value, but with inferior sensitivity compared to FDG-PET. (orig.)

  1. Markets for reactor-produced non-fission radioisotopes

    International Nuclear Information System (INIS)

    Bennett, R.G.

    1995-01-01

    Current market segments for reactor produced radioisotopes are developed and reported from a review of current literature. Specific radioisotopes studied in is report are the primarily selected from those with major medical or industrial markets, or those expected to have strongly emerging markets. Relative market sizes are indicated. Special emphasis is given to those radioisotopes that are best matched to production in high flux reactors such as the Advanced Test Reactor (ATR) at the Idaho National Engineering Laboratory or the High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory. A general bibliography of medical and industrial radioisotope applications, trends, and historical notes is included

  2. PET imaging of HSV1-tk mutants with acquired specificity toward pyrimidine- and acycloguanosine-based radiotracers

    Energy Technology Data Exchange (ETDEWEB)

    Likar, Yury; Dobrenkov, Konstantin; Olszewska, Malgorzata; Shenker, Larissa; Hricak, Hedvig; Ponomarev, Vladimir [Memorial Sloan-Kettering Cancer Center, Molecular Imaging Laboratory, Department of Radiology, New York, NY (United States); Cai, Shangde [Memorial Sloan-Kettering Cancer Center, Radiochemistry/Cyclotron Core Facility, New York, NY (United States)

    2009-08-15

    The aim of this study was to create an alternative mutant of the herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene with reduced phosphorylation capacity for acycloguanosine derivatives, but not pyrimidine-based compounds that will allow for successful PET imaging. A new mutant of HSV1-tk reporter gene, suitable for PET imaging using pyrimidine-based radiotracers, was developed. The HSV1-tk mutant contains an arginine-to-glutamine substitution at position 176 (HSV1-R176Qtk) of the nucleoside binding region of the enzyme. The mutant-gene product showed favorable enzymatic characteristics toward pyrimidine-based nucleosides, while exhibiting reduced activity with acycloguanosine derivatives. In order to enhance HSV1-R176Qtk reporter activity with pyrimidine-based radiotracers, we introduced the R176Q substitution into the more active HSV1-sr39tk mutant. U87 human glioma cells transduced with the HSV1-R176Qsr39tk double mutant reporter gene showed high {sup 3}H-FEAU pyrimidine nucleoside and low {sup 3}H-penciclovir acycloguanosine analog uptake in vitro. PET imaging also demonstrated high {sup 18}F-FEAU and low {sup 18}F-FHBG accumulation in HSV1-R176Qsr39tk+ xenografts. The feasibility of imaging two independent nucleoside-specific HSV1-tk mutants in the same animal with PET was demonstrated. Two opposite xenografts expressing the HSV1-R176Qsr39tk reporter gene and the previously described acycloguanosine-specific mutant of HSV1-tk, HSV1-A167Ysr39tk reporter gene, were imaged using a short-lived pyrimidine-based {sup 18}F-FEAU and an acycloguanosine-based {sup 18}F-FHBG radiotracer, respectively, administered on 2 consecutive days. We conclude that in combination with acycloguanosine-specific HSV1-A167Ysr39tk reporter gene, a HSV1-tk mutant containing the R176Q substitution could be used for PET imaging of two different cell populations or concurrent molecular biological processes in the same living subject. (orig.)

  3. Evolution of PET and SPECT tracers from cyclotrons: production and application

    International Nuclear Information System (INIS)

    Stoecklin, G.

    1992-01-01

    Small cyclotrons play an increasing role in the production of medically useful isotopes. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are major tools in modern nuclear medicine for monitoring regional physiological and pharmacological functions at a molecular level. This requires physiological substrates or drugs labeled with suitable positron emitters or single photon emitters. Short-lived neutron deficient radioisotopes of high specific activity and high radionuclidic purity are needed. Some examples of radionuclide production, the development of radiopharmaceuticals for PET and SPECT, and their applications is presented with special emphasis on fluorine-18 and iodine-123. (author)

  4. Use of radioisotopic esophageal transit in the assessment of patients with symptoms of reflux and non-specific esophageal motor disorders.

    Science.gov (United States)

    Iascone, C; Di Giulio, E; Maffi, C; Ruperto, M

    2004-01-01

    The purposes of this study were to assess the esophageal clearance of a radioisotopic bolus in patients with symptoms of reflux and evaluate the impact of manometric abnormalities on scintigraphic esophageal transit. Esophageal clearance was assessed in a supine position and indicated by the retained radioactivity in the esophagus at 10, 20, 30 and 40 s after the ingestion of a liquid bolus labeled with 2 mCi 99 mTc-SC. The study included 214 consecutive patients with symptoms of reflux and 11 normal controls. The results were compared to the motility findings detected on manometry performed on a separate occasion. Esophageal manometry was normal in 93 patients. Nonspecific esophageal motor disorders were identified in 121 patients and were classified into: 'predominantly nonpropagated activity', 'predominantly low-amplitude peristaltic contractions' and 'miscellaneous disorders' diagnosed in 27, 47 and 47 patients, respectively. The radionuclide clearance was significantly delayed in the overall group of patients compared with that of normal controls (P motor disorders compared with patients with reflux symptoms and 'normal manometry' (P disorders'. Radioisotopic esophageal clearance abnormalities are frequently observed in patients with reflux symptoms and are more likely to be associated to hypomotility disorders, i.e. nonpropagated motor activity or low-amplitude contractions.

  5. Measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: The genomic plot.

    Science.gov (United States)

    Veronese, Mattia; Zanotti-Fregonara, Paolo; Rizzo, Gaia; Bertoldo, Alessandra; Innis, Robert B; Turkheimer, Federico E

    2016-04-15

    PET studies allow in vivo imaging of the density of brain receptor species. The PET signal, however, is the sum of the fraction of radioligand that is specifically bound to the target receptor and the non-displaceable fraction (i.e. the non-specifically bound radioligand plus the free ligand in tissue). Therefore, measuring the non-displaceable fraction, which is generally assumed to be constant across the brain, is a necessary step to obtain regional estimates of the specific fractions. The nondisplaceable binding can be directly measured if a reference region, i.e. a region devoid of any specific binding, is available. Many receptors are however widely expressed across the brain, and a true reference region is rarely available. In these cases, the nonspecific binding can be obtained after competitive pharmacological blockade, which is often contraindicated in humans. In this work we introduce the genomic plot for estimating the nondisplaceable fraction using baseline scans only. The genomic plot is a transformation of the Lassen graphical method in which the brain maps of mRNA transcripts of the target receptor obtained from the Allen brain atlas are used as a surrogate measure of the specific binding. Thus, the genomic plot allows the calculation of the specific and nondisplaceable components of radioligand uptake without the need of pharmacological blockade. We first assessed the statistical properties of the method with computer simulations. Then we sought ground-truth validation using human PET datasets of seven different neuroreceptor radioligands, where nonspecific fractions were either obtained separately using drug displacement or available from a true reference region. The population nondisplaceable fractions estimated by the genomic plot were very close to those measured by actual human blocking studies (mean relative difference between 2% and 7%). However, these estimates were valid only when mRNA expressions were predictive of protein levels (i

  6. Radioisotope Power Sources

    International Nuclear Information System (INIS)

    Culwell, J. P.

    1963-01-01

    The radioisotope power programme of the US Atomic Energy Commission has brought forth a whole new technology of the use of radioisotopes as energy sources in electric power generators. Radioisotope power systems are particularly suited for remote applications where long-lived, compact, reliable power is needed. Able to perform satisfactorily under extreme environmental conditions of temperature, sunlight and electromagnetic radiations, these ''atomic batteries'' are attractive power sources for remote data collecting devices, monitoring systems, satellites and other space missions. Radioisotopes used as fuels generally are either alpha or beta emitters. Alpha emitters are the preferable fuels but are more expensive and less available than beta fuels and are generally reserved for space applications. Beta fuels separated from reactor fission wastes are being used exclusively in land and sea applications at the present. It can be expected, however, that beta emitters such as stiontium-90 eventually will be used in space. Development work is being carried out on generators which will use mixed fission products as fuel. This fuel will be less expensive than the pure radioisotopes since the costs of isotope separation and purification are eliminated. Prototype thermoelectric generators, fuelled with strontium-90 and caesium-137, are now in operation or being developed for use in weather stations, marine navigation aids and deep sea monitoring devices. A plutonium-238 thermoelectric generator is in orbit operating as electric power source in a US Navy TRANSIT satellite. Generators are under development for use on US National Aeronautics and Space Administration missions. The large quantities of radioactivity involved in radioisotope power sources require that special attention be given to safety aspects of the units. Rigid safety requirements have been established and extensive tests have been conducted to insure that these systems can be employed without creating undue

  7. A systematic investigation of PET Radionuclide Specific Activity on Miniaturization of Radiochemistry

    Energy Technology Data Exchange (ETDEWEB)

    Jeanne M Link, PhD

    2012-03-08

    The PET radionuclides, 18F and 11C consist of very high radiation to mass amounts and should be easily adapted to new technologies such as chip chemistry with nanofluidics. However, environmental contamination with nonradioactive fluorine, carbon and other trace contaminants add sufficient mass, micrograms to milligrams, to prevent adapting PET radiochemistry to the nanochip technologies. In addition, the large volumes of material required for beam irradiation make it necessary to also remove the 18F and 11C from their chemical matrices. These steps add contaminants. The work described in this report was a systematic investigation of sources of these contaminants and methods to reduce these contaminants and the reaction volumes for radiochemical synthesis. Several methods were found to lower the contaminants and matrices to within a factor of 2 to 100 of those needed to fully implement chip technology but further improvements are needed.

  8. Radioisotope thermoelectric generators for implanted pacemakers

    Energy Technology Data Exchange (ETDEWEB)

    Pustovalov, A.A.; Bovin, A.V.; Fedorets, V.I.; Shapovalov, V.P.

    1986-08-01

    This paper discusses the development and application of long-life lithium batteries and the problems associated with miniature radioisotope thermoelectric generators (RITEG) with service lives of 10 years or longer. On eof the main problems encountered when devising a radioisotope heat source (RHS) for an RITEG is to obtain biomedical /sup 238/PuO/sub 2/ with a specific neutron yield of 3.10/sup 3/-4.10/sup 3/ (g /SUP ./ sec)/sup -1/, equivalent to metallic Pu 238, and with a content of gamma impurities sufficient to ensure a permissible exposure a permissible exposure does rate (EDR) of a mixture of neutron and gamma radiation. After carrying out the isotope exchange and purifying the initial sample of its gamma impurity elements, the authors obtain biomedical Pu 238 satisfying the indicated requirements king suitable for use in the power packs of medical devices. Taking the indicated specifications into account, the Ritm-1o and gamma radioisotope heat sources were designed, built, tested in models and under natural conditions, and then into production as radioisotope thermoelectric generators designed to power the electronic circuits of implanted pacemakers. The Ritm-MT and Gemma radioisotope thermoelectric generators described are basic units, which can be used as self-contained power supplies for electronic equipment with power requirements in the micromilliwatt range.

  9. Radioisotopes in soil science

    International Nuclear Information System (INIS)

    Kotur, S.C.

    2004-01-01

    Soils form a thin veneer of the Earth that sustain the entire flora and fauna of the terra firma. To that extent the soil as a natural resource is very precious and needs to be managed in a sustainable manner. The fate of degradation of pesticides in soil and build-up of heavy metals in the overall biosafety scenario is also studied gainfully using radioisotopes. Radioisotopes are a very potent tool in the hands of the Soil Scientists, perhaps, the most important among the peaceful applications in service of the mankind

  10. Specific Image Characteristics Influence Attitudes about Chimpanzee Conservation and Use as Pets

    OpenAIRE

    Ross, Stephen R.; Vreeman, Vivian M.; Lonsdorf, Elizabeth V.

    2011-01-01

    Chimpanzees are endangered in their native Africa but in the United States, they are housed not only in zoos and research centers but owned privately as pets and performers. In 2008, survey data revealed that the public is less likely to think that chimpanzees are endangered compared to other great apes, and that this is likely the result of media misportrayals in movies, television and advertisements. Here, we use an experimental survey paradigm with composite images of chimpanzees to determ...

  11. Radioisotope Power Supply, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Between 1998 and 2003, Hi-Z Technology developed and built a 40 mW radioisotope power supply (RPS) that used a 1 watt radioisotope heater unit (RHU) as the energy...

  12. The use of radioisotope tracers in the metallurgical industries

    International Nuclear Information System (INIS)

    Easey, J.F.

    1987-01-01

    Radioisotope techniques have been widely used in the metallurgical industries for many years. They have been shown to be very suitable for studying large scale plant and, in many cases, they are the most suitable techniques for such investigations. Applications of radioisotope tracers to some specific metallurgical problems are discussed. (author)

  13. Radioisotopic heat source

    Science.gov (United States)

    Jones, G.J.; Selle, J.E.; Teaney, P.E.

    1975-09-30

    Disclosed is a radioisotopic heat source and method for a long life electrical generator. The source includes plutonium dioxide shards and yttrium or hafnium in a container of tantalum-tungsten-hafnium alloy, all being in a nickel alloy outer container, and subjected to heat treatment of from about 1570$sup 0$F to about 1720$sup 0$F for about one h. (auth)

  14. Radioisotopes in Industry

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Philip S. [Oak Ridge National Laboratory; Fuccillo, Jr., Domenic A. [Oak Ridge National Laboratory; Gerrard, Martha W. [Oak Ridge National Laboratory; Lafferty, Jr., Robert H. [Oak Ridge National Laboratory

    1967-05-01

    Radioisotopes, man-made radioactive elements, are used in industry primarily for measuring, testing and processing. How and why they are useful is the subject of this booklet. The booklet discusses their origin, their properties, their uses, and how they may be used in the future.

  15. Radio-isotope generator

    International Nuclear Information System (INIS)

    Benjamins, H.M.

    1983-01-01

    A device is claimed for interrupting an elution process in a radioisotope generator before an elution vial is entirely filled. The generator is simultaneously exposed to sterile air both in the direction of the generator column and of the elution vial

  16. Manual of radioisotope production

    International Nuclear Information System (INIS)

    1966-01-01

    The Manual of Radioisotope Production has been compiled primarily to help small reactor establishments which need a modest programme of radioisotope production for local requirements. It is not comprehensive, but gives guidance on essential preliminary considerations and problems that may be met in the early stages of production. References are included as an aid to the reader who wishes to seek further in the extensive literature on the subject. In preparing the Manual, which is in two parts, the Agency consulted several Member States which already have long experience in radioisotope production. An attempt has been made to condense this experience, firstly, by setting out the technical and economic considerations which govern the planning and execution of an isotope programme and, secondly, by providing experimental details of isotope production processes. Part I covers topics common to all radioisotope processing, namely, laboratory design, handling and dispensing of radioactive solutions, quality control, measurement and radiological safety. Part II contains information on the fifteen radioisotopes in most common use. These are bromine-82, cobalt-58, chromium-51, copper-64, fluorine-18, gold-198, iodine-131, iron-59, magnesium-28, potassium-42, sodium-24, phosphorus-32, sulphur-35, yttrium-90 and zinc-65. Their nuclear properties are described, references to typical applications are given and published methods of production are reviewed; also included are descriptions in detail of the production processes used at several national atomic energy organizations. No attempt has been made to distinguish the best values for nuclear data or to comment on the relative merits of production processes. Each process is presented essentially as it was described by the contributor on the understanding that critical comparisons are not necessary for processes which have been well tried in practical production for many years. The information is presented as a guide to enable

  17. 68Ga-PSMA PET/CT in Patients with Rising Prostatic-Specific Antigen After Definitive Treatment of Prostate Cancer: Detection Efficacy and Diagnostic accuracy.

    Science.gov (United States)

    Hamed, Maged Abdel Galil; Basha, Mohammad Abd Alkhalik; Ahmed, Hussien; Obaya, Ahmed Ali; Afifi, Amira Hamed Mohamed; Abdelbary, Eman H

    2018-06-20

    68 Ga-prostate-specific membrane antigen-11 ( 68 Ga-PSMA-11) is a recently developed positron emission tomography (PET) tracer that can detect prostate cancer (PC) relapses and metastases with high contrast resolution. The aim of this study was to assess the detection efficacy and diagnostic accuracy of 68 Ga-PSMA PET/CT image in patients with rising prostatic-specific antigen (PSA) after treatment of PC. The present prospective study included 188 patients who exhibited rising of PSA level on a routine follow-up examination after definitive treatment of PC. All patients underwent a 68 Ga-PSMA PET/CT examination. For each patient, we determined the disease stage, the Gleason score, and the maximum standardized uptake value of the local recurrence and extraprostatic metastases. The detection efficacy and diagnostic accuracy of 68 Ga-PSMA PET/CT were established by histopathology and clinical and imaging follow-up as the reference standards. 68 Ga-PSMA PET/CT detected tumour relapse in 165 patients (35 patients had local recurrence, 106 patients had extraprostatic metastases, and 24 patients had combined lesions). The sensitivity, specificity, and accuracy values of 68 Ga-PSMA PET/CT examination in the detection of PC recurrence were 98.8%, 100%, and 98.8%, respectively. 68 Ga-PSMA PET/CT revealed an overall detection rate of 87.8% (165/188) in patients with rising PSA (median of 2.2 ng/mL, and range of 0.01-70 ng/mL). 68 Ga-PSMA PET/CT is a valuable tool for the detection of PC local recurrence or extraprostatic metastases following rising PSA levels after primary definitive therapy and should be incorporated during routine work-up. Copyright © 2018. Published by Elsevier Inc.

  18. Radioisotope battery for particular application

    International Nuclear Information System (INIS)

    Shen Tianjian; Liang Daihua; Cai Jianhua; Dai Zhimin; Xia Huihao; Wang Jianhua; Sun Sen; Yu Guojun; Wang Xiao; Wang Dongxing; Liu Xin

    2010-01-01

    Radioisotope battery, as a new type of power source, was developed in 1960s. It is advantageous in terms of long working life, high reliability, flexibility to rugged environment, maintenance free, and high capacity rate, hence its unique applications in space, isolated terrestrial or ocean spots, deep waters, and medicine. In this paper, we analysz the primary performances and classification of radioisotope thermoelectric generator, as well as characteristic, basic principle,and structure of radioisotope thermoelectric generator (RTG), which is the most popular in application of radioisotope battery in space, undersea, terrestrial and medicine. A prospect for development and application of radioisotope battery in the 21 st century is given, too. (authors)

  19. Modeling of the Renal Kinetics of the AT1 Receptor Specific PET Radioligand [11C]KR31173

    Directory of Open Access Journals (Sweden)

    Nedim C. M. Gulaldi

    2013-01-01

    Full Text Available Purpose. The radioligand [11C]KR31173 has been introduced for PET imaging of the angiotensin II subtype 1 receptor (AT1R. The purpose of the present project was to employ and validate a compartmental model for quantification of the kinetics of this radioligand in a porcine model of renal ischemia followed by reperfusion (IR. Procedures. Ten domestic pigs were included in the study: five controls and five experimental animals with IR of the left kidney. To achieve IR, acute ischemia was created with a balloon inserted into the left renal artery and inflated for 60 minutes. Reperfusion was achieved by deflation and removal of the balloon. Blood chemistries, urine specific gravity and PH values, and circulating hormones of the renin angiotensin system were measured and PET imaging was performed one week after IR. Cortical time-activity curves obtained from a 90 min [11C]KR31173 dynamic PET study were processed with a compartmental model that included two tissue compartments connected in parallel. Radioligand binding quantified by radioligand retention (80 min value to maximum value ratio was compared to the binding parameters derived from the compartmental model. A binding ratio was calculated as DVR=DVS/DVNS, where DVS and DVNS represented the distribution volumes of specific binding and nonspecific binding. Receptor binding was also determined by autoradiography in vitro. Results. Correlations between rate constants and binding parameters derived by the convolution and deconvolution curve fittings were significant (r>0.9. Also significant was the correlation between the retention parameter derived from the tissue activity curve (Yret and the retention parameter derived from the impulse response function (fret. Furthermore, significant correlations were found between these two retention parameters and DVR. Measurements with PET showed no significant changes in the radioligand binding parameters caused by IR, and these in vivo findings were

  20. Radioisotopes and radiopharmaceuticals catalogue

    International Nuclear Information System (INIS)

    2002-01-01

    The Chilean Nuclear Energy Commission (CCHEN) presents its radioisotopes and radiopharmaceuticals 2002 catalogue. In it we found physical characteristics of 9 different reactor produced radioisotopes ( Tc-99m, I-131, Sm-153, Ir-192, P-32, Na-24, K-42, Cu-64, Rb-86 ), 7 radiopharmaceuticals ( MDP, DTPA, DMSA, Disida, Phitate, S-Coloid, Red Blood Cells In-Vivo, Red Blood Cells In-Vitro) and 4 labelled compounds ( DMSA-Tc99m, DTPA-Tc99m, MIBG-I131, EDTMP-Sm153 ). In the near future the number of items will be increased with new reactor and cyclotron products. Our production system will be certified by ISO 9000 on March 2003. CCHEN is interested in being a national and an international supplier of these products (RS)

  1. Radioisotope production linac

    International Nuclear Information System (INIS)

    Stovall, J.E.; Hansborough, L.D.; O'Brien, H.A.

    1981-01-01

    A 70-MeV proton beam would open a new family of medical radioisotopes (including the important 123 I) to wide application. A 70-MeV, 500-μA linac is described, based on recent innovations in accelerator technology. It would be 27.3 m long, cost approx. $6 million, and the cost of power deposited in the radioisotope-production target is comparable to existing cyclotrons. By operating the rf-power system to its full capability, the same accelerator is capable of producing a 1140-μA beam, and the cost per beam watt on the target is less than half that of comparable cyclotrons. The technology to build such a linac is in a mature stage of developmnt, ready for use by industry

  2. NTP Radioisotopes SOC Ltd

    International Nuclear Information System (INIS)

    Letule, T.

    2017-01-01

    NTP Radioisotopes SOC Ltd, a wholly owned subsidiary of the South African Nuclear Energy Corporation (NECSA). Supplies around 20% of the world's medical radioisotopes used. NTP is a pioneer in the introduction and growth of nuclear medicine as in South Africa. Nuclear medicine is the medical specialty that involves the use of radioactive isotopes in the diagnosis and treatment of diseases. Nuclear medicine contributes to enhancing the lives of the society. There is a compelling need for nuclear medicine to be promoted and utilized in the rest of Africa, due to the increasing prevalence of cancer. Cancer is rapidly becoming a public health crisis in low-income and middle-income countries. In sub-Saharan Africa, patients often present with advanced disease

  3. ImmunoPET for assessing the differential uptake of a CD146-specific monoclonal antibody in lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Haiyan; Kamkaew, Anyanee; Jiang, Dawei; Yang, Yunan [University of Wisconsin-Madison, Department of Radiology, Madison, WI (United States); England, Christopher G.; Hernandez, Reinier; Graves, Stephen A.; Barnhart, Todd E. [University of Wisconsin-Madison, Department of Medical Physics, Madison, WI (United States); Majewski, Rebecca L. [University of Wisconsin-Madison, Department of Biomedical Engineering, Madison, WI (United States); Cai, Weibo [University of Wisconsin-Madison, Department of Radiology, Madison, WI (United States); University of Wisconsin-Madison, Department of Medical Physics, Madison, WI (United States); University of Wisconsin-Madison, Department of Biomedical Engineering, Madison, WI (United States); University of Wisconsin Carbone Cancer Center, Madison, WI (United States)

    2016-11-15

    Overexpression of CD146 in solid tumors has been linked to disease progression, invasion, and metastasis. We describe the generation of a {sup 64}Cu-labeled CD146-specific antibody and its use for quantitative immunoPET imaging of CD146 expression in six lung cancer models. The anti-CD146 antibody (YY146) was conjugated to 1,4,7-triazacyclononane-triacetic acid (NOTA) and radiolabeled with {sup 64}Cu. CD146 expression was evaluated in six human lung cancer cell lines (A549, NCI-H358, NCI-H522, HCC4006, H23, and NCI-H460) by flow cytometry and quantitative western blot studies. The biodistribution and tumor uptake of {sup 64}Cu-NOTA-YY146 was assessed by sequential PET imaging in athymic nude mice bearing subcutaneous lung cancer xenografts. The correlation between CD146 expression and tumor uptake of {sup 64}Cu-NOTA-YY146 was evaluated by graphical software while ex vivo biodistribution and immunohistochemistry studies were performed to validate the accuracy of PET data and spatial expression of CD146. Flow cytometry and western blot studies showed similar findings with H460 and H23 cells showing high levels of expression of CD146. Small differences in CD146 expression levels were found among A549, H4006, H522, and H358 cells. Tumor uptake of {sup 64}Cu-NOTA-YY146 was highest in CD146-expressing H460 and H23 tumors, peaking at 20.1 ± 2.86 and 11.6 ± 2.34 %ID/g at 48 h after injection (n = 4). Tumor uptake was lowest in the H522 model (4.1 ± 0.98 %ID/g at 48 h after injection; n = 4), while H4006, A549 and H358 exhibited similar uptake of {sup 64}Cu-NOTA-YY146. A positive correlation was found between tumor uptake of {sup 64}Cu-NOTA-YY146 (%ID/g) and relative CD146 expression (r {sup 2} = 0.98, p < 0.01). Ex vivo biodistribution confirmed the accuracy of the PET data. The strong correlation between tumor uptake of {sup 64}Cu-NOTA-YY146 and CD146 expression demonstrates the potential use of this radiotracer for imaging tumors that elicit varying levels of CD146

  4. Radioisotope production by reactors and cyclotrons in Japan

    International Nuclear Information System (INIS)

    Murakami, Yukio

    1978-01-01

    Present status of radioisotope production in Japan and the increasing demand from various fields are generally reviewed. Future problems associated with the shortage of economical supply are also discussed. The first half of this report is devoted to general review of the increasing demand for various radioisotopes from increasing number of users. The present status and future trends of the distribution of users of specific radioisotopes and their demands are shown. The remaining half of this report reviews the production with reactors and cyclotrons. The Japanese reactors producing radioisotopes are limited to low flux (10 13 ) research reactors at JAERI. Some problems associated with the improvement of availability and with the organizational structure are discussed. As for the production with cyclotrons, available facilities and the method of production are explained in detail. For clinical use, especially for the production of short lived radioisotopes, the advantage of a small special purpose cyclotron at each medical organization is emphasized. (Aoki, K.)

  5. Radioisotopes for medical applications

    International Nuclear Information System (INIS)

    Carr, S.

    1998-01-01

    For more than 3 decades, the Australian Nuclear Science and Technology Organisation has been the country's main supplier of radioisotopes for medical applications. The use of radioisotopes in medicine has revolutionised the diagnosis, management and treatment of many serious diseases such as cancer, heart disease and stroke. It is also beginning to play a key role in neurological disorders such as Parkinson and Alzheimers disease and epilepsy. More recently there has been considerable growth in the application of nuclear medicine to treat sport-related injuries - especially wrist, ankle and knees where more common techniques do not always enable accurate diagnosis. Australia is a recognised leader in nuclear medicine. This can be partially attributed to the close relationship between ANSTO and the medical community in providing opportunities to develop and evaluate new agents to support more effective patient care. A list of commercial isotopes produced in the reactor or the cyclotron and used in medical applications is given. Nuclear medicine plays an important role in the clinical environment and the timely supply of radioisotopes is a key element. ANSTO will continue to be the premier supplier of currently available and developing isotopes to support the health and well being of the Australian community

  6. Radioisotopes for medical applications

    Energy Technology Data Exchange (ETDEWEB)

    Carr, S. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia). Radiopharmaceuticals Division

    1998-03-01

    For more than 3 decades, the Australian Nuclear Science and Technology Organisation has been the country`s main supplier of radioisotopes for medical applications. The use of radioisotopes in medicine has revolutionised the diagnosis, management and treatment of many serious diseases such as cancer, heart disease and stroke. It is also beginning to play a key role in neurological disorders such as Parkinson and Alzheimers disease and epilepsy. More recently there has been considerable growth in the application of nuclear medicine to treat sport-related injuries - especially wrist, ankle and knees where more common techniques do not always enable accurate diagnosis. Australia is a recognised leader in nuclear medicine. This can be partially attributed to the close relationship between ANSTO and the medical community in providing opportunities to develop and evaluate new agents to support more effective patient care. A list of commercial isotopes produced in the reactor or the cyclotron and used in medical applications is given. Nuclear medicine plays an important role in the clinical environment and the timely supply of radioisotopes is a key element. ANSTO will continue to be the premier supplier of currently available and developing isotopes to support the health and well being of the Australian community 2 tabs., 1 fig.

  7. Production of radioisotopes using accelerators

    International Nuclear Information System (INIS)

    Qaim, S.M.

    1990-01-01

    Accelerator produced radioisotopes find applications in many fields. Most of them are ideally suited for in-vivo studies of physiological functions. A brief review of various types of accelerators used for radioisotope production is given. The 'state of art' technology relevant to the production of radioisotopes is briefly discussed. Some of the recent advances in nuclear data measurements, target development, chemical processing and quality control are described. There appears to be a definite shift from multipurpose accelerators to dedicated machines, and greater emphasis is placed now on the production of radioisotopes with high radionuclidic purity by choosing a suitable nuclear reaction in a proper energy range. (author)

  8. Applications of radioisotopes in medicine

    International Nuclear Information System (INIS)

    Sivaprasad, N.

    2012-01-01

    The application of radioisotopes in medicine is many folds. They can be classified into two main groups. (a) The radioisotope tagged labeled compounds suitable for safe administration in the body for diagnosis of various diseases of vital organs such as brain, kidney, thyroid etc and for treatment known as radiotherapy (b) The sealed source of radioisotopes for utilizing the radiation emitted from the radioisotope for treatment, particularly for radiation therapy of cancer. The former application of radioisotope in the field of medicine has led to the formation of special branch of medicine termed Nuclear Medicine - the branch of medicine deals with the use of radioisotope in the from of radiopharmaceuticals for investigation, diagnosis and treatment of diseases. Radioisotopes in the form of radiolabelled compound and bio-chemicals that are pharmaceutically and radiologically safe for administration in the body for diagnosis and treatment are called radiopharmaceuticals. The radiopharmaceuticals are the results of world-wide effort to bring nuclear energy in a tangible form for diagnosis and treatment. Radioisotopes as radiopharmaceuticals thus constitute one of the key requirements for nuclear medicine investigation and radiotherapy. In the case of sealed radioisotope source the radiation emitted by the radioactive source is utilized for the treatment and this mode of treatment is called radiation therapy where no radioactive substance is administrated into the body. This does not form the part of nuclear medicine

  9. Imaging and PET - PET/CT imaging

    International Nuclear Information System (INIS)

    Von Schulthess, G.K.; Hany, Th.F.

    2008-01-01

    PET/CT has grown because the lack of anatomic landmarks in PET makes 'hardware-fusion' to anatomic cross-sectional data extremely useful. Addition of CT to PET improves specificity, but also sensitivity, and adding PET to CT adds sensitivity and specificity in tumor imaging. The synergistic advantage of adding CT is that the attenuation correction needed for PET data can also be derived from the CT data. This makes PET-CT 25-30% faster than PET alone, leading to higher patient throughput and a more comfortable examination for patients typically lasting 20 minutes or less. FDG-PET-CT appears to provide relevant information in the staging and therapy monitoring of many tumors, such as lung carcinoma, colorectal cancer, lymphoma, gynaecological cancers, melanoma and many others, with the notable exception of prostatic cancer. for this cancer, choline derivatives may possibly become useful radiopharmaceuticals. The published literature on the applications of FDG-PET-CT in oncology is still limited but several designed studies have demonstrated the benefits of PET-CT. (authors)

  10. (64)Cu-DOTA-trastuzumab PET imaging and HER2 specificity of brain metastases in HER2-positive breast cancer patients.

    Science.gov (United States)

    Kurihara, Hiroaki; Hamada, Akinobu; Yoshida, Masayuki; Shimma, Schuichi; Hashimoto, Jun; Yonemori, Kan; Tani, Hitomi; Miyakita, Yasuji; Kanayama, Yousuke; Wada, Yasuhiro; Kodaira, Makoto; Yunokawa, Mayu; Yamamoto, Harukaze; Shimizu, Chikako; Takahashi, Kazuhiro; Watanabe, Yasuyoshi; Fujiwara, Yasuhiro; Tamura, Kenji

    2015-01-01

    The purpose of this study was to determine whether brain metastases from HER2-positive breast cancer could be detected noninvasively using positron emission tomography (PET) with (64)Cu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-trastuzumab. PET was performed on five patients with brain metastases from HER2-positive breast cancer, at 24 or 48 h after the injection of approximately 130 MBq of the probe (64)Cu-DOTA-trastuzumab. Radioactivity in metastatic brain tumors was evaluated based on PET images in five patients. Autoradiography, immunohistochemistry (IHC), and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis were performed in one surgical case to confirm HER2 specificity of (64)Cu-DOTA-trastuzumab. Metastatic brain lesions could be visualized by (64)Cu-DOTA-trastuzumab PET in all of five cases, which might indicated that trastuzumab passes through the blood-brain barrier (BBB). The HER2 specificity of (64)Cu-DOTA-trastuzumab was demonstrated in one patient by autoradiography, immunohistochemistry, and LC-MS/MS. Cu-DOTA-trastuzumab PET could be a potential noninvasive procedure for serial identification of metastatic brain lesions in patients with HER2-positive breast cancer. UMIN000004170.

  11. 18F-DCFBC Prostate-Specific Membrane Antigen-Targeted PET/CT Imaging in Localized Prostate Cancer: Correlation With Multiparametric MRI and Histopathology.

    Science.gov (United States)

    Turkbey, Baris; Mena, Esther; Lindenberg, Liza; Adler, Stephen; Bednarova, Sandra; Berman, Rose; Ton, Anita T; McKinney, Yolanda; Eclarinal, Philip; Hill, Craig; Afari, George; Bhattacharyya, Sibaprasad; Mease, Ronnie C; Merino, Maria J; Jacobs, Paula M; Wood, Bradford J; Pinto, Peter A; Pomper, Martin G; Choyke, Peter L

    2017-10-01

    To assess the ability of (N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-F-fluorobenzyl-L-cysteine) (F-DCFBC), a prostate-specific membrane antigen-targeted PET agent, to detect localized prostate cancer lesions in correlation with multiparametric MRI (mpMRI) and histopathology. This Health Insurance Portability and Accountability Act of 1996-compliant, prospective, institutional review board-approved study included 13 evaluable patients with localized prostate cancer (median age, 62.8 years [range, 51-74 years]; median prostate-specific antigen, 37.5 ng/dL [range, 3.26-216 ng/dL]). Patients underwent mpMRI and F-DCFBC PET/CT within a 3 months' window. Lesions seen on mpMRI were biopsied under transrectal ultrasound/MRI fusion-guided biopsy, or a radical prostatectomy was performed. F-DCFBC PET/CT and mpMRI were evaluated blinded and separately for tumor detection on a lesion basis. For PET image analysis, MRI and F-DCFBC PET images were fused by using software registration; imaging findings were correlated with histology, and uptake of F-DCFBC in tumors was compared with uptake in benign prostatic hyperplasia nodules and normal peripheral zone tissue using the 80% threshold SUVmax. A total of 25 tumor foci (mean size, 1.8 cm; median size, 1.5 cm; range, 0.6-4.7 cm) were histopathologically identified in 13 patients. Sensitivity rates of F-DCFBC PET/CT and mpMRI were 36% and 96%, respectively, for all tumors. For index lesions, the largest tumor with highest Gleason score, sensitivity rates of F-DCFBC PET/CT and mpMRI were 61.5% and 92%, respectively. The average SUVmax for primary prostate cancer was higher (5.8 ± 4.4) than that of benign prostatic hyperplasia nodules (2.1 ± 0.3) or that of normal prostate tissue (2.1 ± 0.4) at 1 hour postinjection (P = 0.0033). The majority of index prostate cancers are detected with F-DCFBC PET/CT, and this may be a prognostic indicator based on uptake and staging. However, for detecting prostate cancer with high sensitivity, it

  12. Small radioisotope powered batteries

    International Nuclear Information System (INIS)

    Myatt, J.

    1975-06-01

    Various methods of converting the large amounts of energy stored in radioisotopes are described. These are based on:- (a) the Seebeck effect; (b) thermionic emission of electrons from a hot body; (c) the Stirling Cycle; and (d) radiovoltaic charge separation in 'p-n' junctions. Small generators in the range 0 to 100 W(e) developed using these effects are described and typical applications for each of these systems are given. These include data collection and transmission from remote sites, implantable medical devices, lighthouses, radio beacons, and space power supplies. (author)

  13. Administration of radioisotope production

    International Nuclear Information System (INIS)

    1964-01-01

    Current developments in atomic energy, and the administrative problems to which they give rise, were surveyed in a seminar on 'Atomic Energy for Atomic Energy Administrators' held at IAEA headquarters from 30 September to 4 October 1963. The ground covered included protection against radiation, isotopes and radiation sources, research reactors, nuclear power, legal matters, technical and scientific administration, the role of the universities, and the Agency's part in assistance to developing countries. The possibilities and limitations of radioisotope production from research reactors were discussed by Dr. G. B. Cook, of the Division of Research and Laboratories, IAEA in this paper.

  14. Administration of radioisotope production

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1964-01-15

    Current developments in atomic energy, and the administrative problems to which they give rise, were surveyed in a seminar on 'Atomic Energy for Atomic Energy Administrators' held at IAEA headquarters from 30 September to 4 October 1963. The ground covered included protection against radiation, isotopes and radiation sources, research reactors, nuclear power, legal matters, technical and scientific administration, the role of the universities, and the Agency's part in assistance to developing countries. The possibilities and limitations of radioisotope production from research reactors were discussed by Dr. G. B. Cook, of the Division of Research and Laboratories, IAEA in this paper.

  15. Radioisotope relay instrument

    International Nuclear Information System (INIS)

    Pozdnyakov, V.N.; Sazonov, O.L.; Taksar, I.M.; Tesnavs, Eh.R.; Yanushkovskij, V.A.

    1974-01-01

    The paper describes a radioisotope relay device containing a radiation source, a detector, an electronic relay block with a comparative threshold mechanism. The device differs from previously known ones in that, for the purpose of increasing stability and speed of action, the electronic relay block is a separate unit and contains two threshold pulse generators which are joined up, across series-connected ''and'' and ''or'' elements, with one of the inputs of the comparative threshold mechanism, whose second input is connected with a detector and whose outputs are connected with a relay element connected by feedback with the above-mentioned ''and'' elements. (author)

  16. High temperature radioisotope capsule

    International Nuclear Information System (INIS)

    Bradshaw, G.B.

    1976-01-01

    A high temperature radioisotope capsule made up of three concentric cylinders, with the isotope fuel located within the innermost cylinder is described. The innermost cylinder has hemispherical ends and is constructed of a tantalum alloy. The intermediate cylinder is made of a molybdenum alloy and is capable of withstanding the pressure generated by the alpha particle decay of the fuel. The outer cylinder is made of a platinum alloy of high resistance to corrosion. A gas separates the innermost cylinder from the intermediate cylinder and the intermediate cylinder from the outer cylinder

  17. Development of radioisotope production in the Philippines

    Energy Technology Data Exchange (ETDEWEB)

    Cabalfin, E G [Philippine Nuclear Research Institute, Quezon (Philippines)

    1998-10-01

    The Philippine Nuclear Research Institute (PNRI) started its activities on radioisotope production more than three decades ago, when the Philippine Research Reactor (PRR-1) started operating at its full rated power of 1 MW. Since then, several radionuclides in different chemical forms, were routinely produced and supplied for use in nuclear medicine, industry, agriculture, research and training, until the conversion of the PRR-1 to a 3 MW TRIGA type reactor. After the criticality test of the upgraded reactor, a leak was discovered in the pool liner. With the repair of the reactor still ongoing, routine radioisotope production activities have been reduced to dispensing of imported bulk {sup 131}I. In the Philippines, radioisotopes are widely used in nuclear medicine, with {sup 131}I and {sup 99m}Tc as the major radionuclides of interest. Thus the present radioisotope production program of PNRI is directed to meet this demand. With the technical assistance of the International Atomic Energy Agency (IAEA), PNRI is setting up a new {sup 131}I production facility. The in-cell equipment have been installed and tested using both inactive and active target, obtained from BATAN, Indonesia. In order to meet the need of producing {sup 99}Mo-{sup 99m}Tc generators, based on low specific activity reactor-produced {sup 99}Mo, research and development work on the preparation of {sup 99m}Tc gel generators is ongoing. (author)

  18. Radiation protection programme for a radioisotope production facility

    International Nuclear Information System (INIS)

    Makgato, Thutu Nelson

    2015-02-01

    The present project reviews reactor based radioisotope production facilities. An overview of techniques and methodologies used as well as laboratory facilities necessary for the production process are discussed. Specific details of reactor based production and processing of more commonly used industrial and pharmaceutical radioisotopes are provided. Ultimately, based on facilities and techniques utilized as well as the associated hazard assessment, a proposed radiation protection programme is discussed. Elements of the radiation protection programme will also consider lessons from recent incidents and accidents encountered in radioisotope production facilities. (au)

  19. Utilization of radioisotopes in medical field

    Energy Technology Data Exchange (ETDEWEB)

    Sasaki, Yasuhito [National Inst. of Radiological Sciences, Chiba (Japan)

    2000-03-01

    The establishment and advance of nuclear medicine was briefly described here and the present situations and recent topics on clinical nuclear medicine were summarized as well as its prospects for the future. A labeling method to monitor dynamic changes of living substances using radioisotope (RI) was established by Hevesy using radionuclides. The radiotracing method has been applied to chemical field. The numbers of yearly application in 1982, 1987, 1992 and 1997 were reported in respects of in vivo assays (scintigram, SPECT, PET), the treatments with unsealed RI, PET and in vitro examination (RIA, IRMA). The data show that the application of in vivo examination greatly increased for the last 5 years. Bone scintigram was most frequent (26.9%) followed by myocardial scintigram (19.6%). On the other hand, application of in vitro radioassay is gradually decreasing now after the peak in 1992 (241,000 cases per day). The determination of blood concentrations of various tumor markers such as CEA, CA19-9, CA15-3 ar3, etc. became able using radioimmunodetection (RID). Positron emission computed tomography (PET) is valuable for detection of malignant tumor especially for postoperative recurrence or metastasis, evaluation of myocardial viability and identification of epileptic focus. PET using {sup 15}O labeled H{sub 2}O is thought useful for the study on higher functions of human brain such as language, thinking, and prognostic evaluation of damages in the brain. Nuclear medicinal examination, which has been used for diagnosis would be utilized for designing of clinical therapy and evaluation of its effects and prognosis. (M.N.)

  20. Malignant lipogenesis defined by {sup 11}C-acetate PET/CT predicts prostate cancer-specific survival in patients with biochemical relapse after prostatectomy

    Energy Technology Data Exchange (ETDEWEB)

    Regula, Naresh [Uppsala University, Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala (Sweden); Haeggman, Michael [Uppsala University, Section of Urology, Department of Surgical Sciences, Uppsala (Sweden); Johansson, Silvia [Uppsala University, Section of Oncology, Department of Immunology, Genetics and Pathology, Uppsala (Sweden); Soerensen, Jens [Uppsala University, Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala (Sweden); PET Center Research Department, Uppsala (Sweden)

    2016-11-15

    Malignant de novo lipogenesis is strongly linked to the aggressiveness of prostate cancer (PCa) under experimental conditions. {sup 11}C-Acetate PET/CT is a potential noninvasive biomarker of malignant lipogenesis in PCa, but its prognostic value is not known. The objective of this study was to analyse {sup 11}C-acetate PET/CT image metrics in relation to survival. All patients undergoing {sup 11}C-acetate PET/CT in one university hospital from 2005 to 2011 due to PSA relapse after previous prostatectomy were retrospectively evaluated. Two groups of patients were compared: those who died from PCa and those who were censored. All previously reported findings of local recurrence, regional or distal lymph node metastases and bone metastases were counted and evaluated regarding {sup 11}C-acetate uptake intensity (SUV{sub max}) and tumour volume. Total tumour volume and total lipogenic activity (TLA, summed SUV{sub max} x TV) were calculated. Survival analysis in the entire study population was followed by Cox proportional hazards ratio (HR) analysis. A total of 121 patients were included, and 22 PCa-specific deaths were recorded. The mean PSA level at the time of PET was 2.69 ± 4.35 ng/mL. The median follow-up of the study population was 79 ± 28 months. PET identified at least one PCa lesion in 53 % of patients. Five-year PCa-specific survival after PET was 80 % and 100 % in patients with a positive and a negative PET scan, respectively (p < 0.001). Time-to-death was linearly correlated with highest SUV{sub max} (r = -0.55, p = 0.01) and nonlinearly with TLA (r = -0.75, p < 0.001). Multivariate analysis showed statistical significance for number of bone metastases (HR 1.74, p = 0.01), tertile of TLA (HR 5.63, p = 0.029) and postoperative Gleason score (HR 1.84, p = 0.045). Malignant {sup 11}C-acetate accumulation measured with PET/CT is a strong predictor of survival in the setting of PSA relapse after prostatectomy. The study provides further evidence for a

  1. Imaging and dosimetric errors in 4D PET/CT-guided radiotherapy from patient-specific respiratory patterns: a dynamic motion phantom end-to-end study.

    Science.gov (United States)

    Bowen, S R; Nyflot, M J; Herrmann, C; Groh, C M; Meyer, J; Wollenweber, S D; Stearns, C W; Kinahan, P E; Sandison, G A

    2015-05-07

    Effective positron emission tomography / computed tomography (PET/CT) guidance in radiotherapy of lung cancer requires estimation and mitigation of errors due to respiratory motion. An end-to-end workflow was developed to measure patient-specific motion-induced uncertainties in imaging, treatment planning, and radiation delivery with respiratory motion phantoms and dosimeters. A custom torso phantom with inserts mimicking normal lung tissue and lung lesion was filled with [(18)F]FDG. The lung lesion insert was driven by six different patient-specific respiratory patterns or kept stationary. PET/CT images were acquired under motionless ground truth, tidal breathing motion-averaged (3D), and respiratory phase-correlated (4D) conditions. Target volumes were estimated by standardized uptake value (SUV) thresholds that accurately defined the ground-truth lesion volume. Non-uniform dose-painting plans using volumetrically modulated arc therapy were optimized for fixed normal lung and spinal cord objectives and variable PET-based target objectives. Resulting plans were delivered to a cylindrical diode array at rest, in motion on a platform driven by the same respiratory patterns (3D), or motion-compensated by a robotic couch with an infrared camera tracking system (4D). Errors were estimated relative to the static ground truth condition for mean target-to-background (T/Bmean) ratios, target volumes, planned equivalent uniform target doses, and 2%-2 mm gamma delivery passing rates. Relative to motionless ground truth conditions, PET/CT imaging errors were on the order of 10-20%, treatment planning errors were 5-10%, and treatment delivery errors were 5-30% without motion compensation. Errors from residual motion following compensation methods were reduced to 5-10% in PET/CT imaging, PET/CT imaging to RT planning, and RT delivery under a dose painting paradigm is feasible within an integrated respiratory motion phantom workflow. For a limited set of cases, the magnitude

  2. Imaging and dosimetric errors in 4D PET/CT-guided radiotherapy from patient-specific respiratory patterns: a dynamic motion phantom end-to-end study

    International Nuclear Information System (INIS)

    Bowen, S R; Nyflot, M J; Meyer, J; Sandison, G A; Herrmann, C; Groh, C M; Wollenweber, S D; Stearns, C W; Kinahan, P E

    2015-01-01

    Effective positron emission tomography / computed tomography (PET/CT) guidance in radiotherapy of lung cancer requires estimation and mitigation of errors due to respiratory motion. An end-to-end workflow was developed to measure patient-specific motion-induced uncertainties in imaging, treatment planning, and radiation delivery with respiratory motion phantoms and dosimeters. A custom torso phantom with inserts mimicking normal lung tissue and lung lesion was filled with [ 18 F]FDG. The lung lesion insert was driven by six different patient-specific respiratory patterns or kept stationary. PET/CT images were acquired under motionless ground truth, tidal breathing motion-averaged (3D), and respiratory phase-correlated (4D) conditions. Target volumes were estimated by standardized uptake value (SUV) thresholds that accurately defined the ground-truth lesion volume. Non-uniform dose-painting plans using volumetrically modulated arc therapy were optimized for fixed normal lung and spinal cord objectives and variable PET-based target objectives. Resulting plans were delivered to a cylindrical diode array at rest, in motion on a platform driven by the same respiratory patterns (3D), or motion-compensated by a robotic couch with an infrared camera tracking system (4D). Errors were estimated relative to the static ground truth condition for mean target-to-background (T/B mean ) ratios, target volumes, planned equivalent uniform target doses, and 2%-2 mm gamma delivery passing rates. Relative to motionless ground truth conditions, PET/CT imaging errors were on the order of 10–20%, treatment planning errors were 5–10%, and treatment delivery errors were 5–30% without motion compensation. Errors from residual motion following compensation methods were reduced to 5–10% in PET/CT imaging, <5% in treatment planning, and <2% in treatment delivery. We have demonstrated that estimation of respiratory motion uncertainty and its propagation from PET/CT imaging to RT

  3. Imaging and dosimetric errors in 4D PET/CT-guided radiotherapy from patient-specific respiratory patterns: a dynamic motion phantom end-to-end study

    Science.gov (United States)

    Bowen, S R; Nyflot, M J; Hermann, C; Groh, C; Meyer, J; Wollenweber, S D; Stearns, C W; Kinahan, P E; Sandison, G A

    2015-01-01

    Effective positron emission tomography/computed tomography (PET/CT) guidance in radiotherapy of lung cancer requires estimation and mitigation of errors due to respiratory motion. An end-to-end workflow was developed to measure patient-specific motion-induced uncertainties in imaging, treatment planning, and radiation delivery with respiratory motion phantoms and dosimeters. A custom torso phantom with inserts mimicking normal lung tissue and lung lesion was filled with [18F]FDG. The lung lesion insert was driven by 6 different patient-specific respiratory patterns or kept stationary. PET/CT images were acquired under motionless ground truth, tidal breathing motion-averaged (3D), and respiratory phase-correlated (4D) conditions. Target volumes were estimated by standardized uptake value (SUV) thresholds that accurately defined the ground-truth lesion volume. Non-uniform dose-painting plans using volumetrically modulated arc therapy (VMAT) were optimized for fixed normal lung and spinal cord objectives and variable PET-based target objectives. Resulting plans were delivered to a cylindrical diode array at rest, in motion on a platform driven by the same respiratory patterns (3D), or motion-compensated by a robotic couch with an infrared camera tracking system (4D). Errors were estimated relative to the static ground truth condition for mean target-to-background (T/Bmean) ratios, target volumes, planned equivalent uniform target doses (EUD), and 2%-2mm gamma delivery passing rates. Relative to motionless ground truth conditions, PET/CT imaging errors were on the order of 10–20%, treatment planning errors were 5–10%, and treatment delivery errors were 5–30% without motion compensation. Errors from residual motion following compensation methods were reduced to 5–10% in PET/CT imaging, PET/CT imaging to RT planning, and RT delivery under a dose painting paradigm is feasible within an integrated respiratory motion phantom workflow. For a limited set of cases, the

  4. Radioisotopes and radiation technology

    International Nuclear Information System (INIS)

    Ramamoorthy, N.

    2011-01-01

    The field of radioisotopes and radiation processing has grown enormously all over the world with India being no exception. The chemistry and radiochemistry related inputs to the overall technology development and achievements have been, and will continue to be, of considerable value and importance in this multi-disciplinary and multi-specialty field. Harnessing further benefits as well as sustaining proven applications should be the goal in planning for the future. An objective analysis of the socio-economic impact and benefits from this field to the society at large will undoubtedly justify assigning continued high priority, and providing adequate resources and support, to relevant new projects and programmes on the anvil in the area of radioisotopes and radiation technology. It is necessary to nurture and strengthen inter-disciplinary and multi-specialty collaborations and cooperation - at both national and international level as a rule (not as exception) - for greater efficiency, cost-effectiveness and success of ongoing endeavors and future developments in this important field

  5. Safe Handling of Radioisotopes

    International Nuclear Information System (INIS)

    1958-01-01

    Under its Statute the International Atomic Energy Agency is empowered to provide for the application of standards of safety for protection against radiation to its own operations and to operations making use of assistance provided by it or with which it is otherwise directly associated. To this end authorities receiving such assistance are required to observe relevant health and safety measures prescribed by the Agency. As a first step, it has been considered an urgent task to provide users of radioisotopes with a manual of practice for the safe handling of these substances. Such a manual is presented here and represents the first of a series of manuals and codes to be issued by the Agency. It has been prepared after careful consideration of existing national and international codes of radiation safety, by a group of international experts and in consultation with other international bodies. At the same time it is recommended that the manual be taken into account as a basic reference document by Member States of the Agency in the preparation of national health and safety documents covering the use of radioisotopes.

  6. The safe handling of radioisotopes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1964-12-31

    A narrative account of a minor contamination accident in a laboratory is used to demonstrate the important role of radiation protection measures in radioisotope work and the necessity of giving proper regard to such measures. It is primarily directed towards the research scientists and medical workers using radioisotopes on a relatively small scale

  7. Support housing for radioisotope generation

    International Nuclear Information System (INIS)

    Fries, B.A.

    1976-01-01

    A support housing for on-site radioisotope generation is disclosed in which the formation of a short-lived daughter radioisotope from its longer-lived parent features countercurrent batch flow of the eluting reagent interior of the housing. 6 claims, 4 drawing figures

  8. Advanced Radioisotope Power Conversion Technology Research and Development

    Science.gov (United States)

    Wong, Wayne A.

    2004-01-01

    NASA's Radioisotope Power Conversion Technology program is developing next generation power conversion technologies that will enable future missions that have requirements that cannot be met by either the ubiquitous photovoltaic systems or by current Radioisotope Power System (RPS) technology. Performance goals of advanced radioisotope power systems include improvement over the state-of-practice General Purpose Heat Source/Radioisotope Thermoelectric Generator by providing significantly higher efficiency to reduce the number of radioisotope fuel modules, and increase specific power (watts/kilogram). Other Advanced RPS goals include safety, long-life, reliability, scalability, multi-mission capability, resistance to radiation, and minimal interference with the scientific payload. NASA has awarded ten contracts in the technology areas of Brayton, Stirling, Thermoelectric, and Thermophotovoltaic power conversion including five development contracts that deal with more mature technologies and five research contracts. The Advanced RPS Systems Assessment Team includes members from NASA GRC, JPL, DOE and Orbital Sciences whose function is to review the technologies being developed under the ten Radioisotope Power Conversion Technology contracts and assess their relevance to NASA's future missions. Presented is an overview of the ten radioisotope power conversion technology contracts and NASA's Advanced RPS Systems Assessment Team.

  9. Radioisotope applications in industry and environment: Indian scenario

    International Nuclear Information System (INIS)

    Pant, H.J.

    2016-01-01

    Applications of radioisotopes and radiation technology in industry, medicine and agriculture form an important part of India's programme of using nuclear technology for societal benefits. Radioisotope production in India started on a modest scale soon after 1 MW APSARA reactor at Trombay, Mumbai became critical in 1956. The scope of activities expanded thereafter. With the commissioning of 40 MW CIRUS reactor in 1960, the setting up of modern radioisotope processing laboratories in late sixties and the production of cobalt-60 in power reactors in megacurie quantities in late seventies made India self-sufficient in radioisotope production. The radioisotope production received a major boost in 1985 with the commissioning of high flux 100 MW DHRUVA reactor, which provided opportunity to extend the range of radioisotopes available in the country both in quantity as well in specific activity. The CIRUS reactor has been shutdown in year 2010 and 1 MW APSARA reactor is presently being upgraded to 5 MW. Today, The DHRUVA reactor operating at its full capacity is being used for production of 100 different radioisotopes those are used in industry, agriculture and medicine. (author)

  10. Investigation of realistic PET simulations incorporating tumor patient's specificity using anthropomorphic models: Creation of an oncology database

    Energy Technology Data Exchange (ETDEWEB)

    Papadimitroulas, Panagiotis; Efthimiou, Nikos; Nikiforidis, George C.; Kagadis, George C. [Department of Medical Physics, School of Medicine, University of Patras, Rion, GR 265 04 (Greece); Loudos, George [Department of Biomedical Engineering, Technological Educational Institute of Athens, Ag. Spyridonos Street, Egaleo GR 122 10, Athens (Greece); Le Maitre, Amandine; Hatt, Mathieu; Tixier, Florent; Visvikis, Dimitris [Medical Information Processing Laboratory (LaTIM), National Institute of Health and Medical Research (INSERM), 29609 Brest (France)

    2013-11-15

    Purpose: The GATE Monte Carlo simulation toolkit is used for the implementation of realistic PET simulations incorporating tumor heterogeneous activity distributions. The reconstructed patient images include noise from the acquisition process, imaging system's performance restrictions and have limited spatial resolution. For those reasons, the measured intensity cannot be simply introduced in GATE simulations, to reproduce clinical data. Investigation of the heterogeneity distribution within tumors applying partial volume correction (PVC) algorithms was assessed. The purpose of the present study was to create a simulated oncology database based on clinical data with realistic intratumor uptake heterogeneity properties.Methods: PET/CT data of seven oncology patients were used in order to create a realistic tumor database investigating the heterogeneity activity distribution of the simulated tumors. The anthropomorphic models (NURBS based cardiac torso and Zubal phantoms) were adapted to the CT data of each patient, and the activity distribution was extracted from the respective PET data. The patient-specific models were simulated with the Monte Carlo Geant4 application for tomography emission (GATE) in three different levels for each case: (a) using homogeneous activity within the tumor, (b) using heterogeneous activity distribution in every voxel within the tumor as it was extracted from the PET image, and (c) using heterogeneous activity distribution corresponding to the clinical image following PVC. The three different types of simulated data in each case were reconstructed with two iterations and filtered with a 3D Gaussian postfilter, in order to simulate the intratumor heterogeneous uptake. Heterogeneity in all generated images was quantified using textural feature derived parameters in 3D according to the ground truth of the simulation, and compared to clinical measurements. Finally, profiles were plotted in central slices of the tumors, across lines

  11. Investigation of realistic PET simulations incorporating tumor patient's specificity using anthropomorphic models: Creation of an oncology database

    International Nuclear Information System (INIS)

    Papadimitroulas, Panagiotis; Efthimiou, Nikos; Nikiforidis, George C.; Kagadis, George C.; Loudos, George; Le Maitre, Amandine; Hatt, Mathieu; Tixier, Florent; Visvikis, Dimitris

    2013-01-01

    Purpose: The GATE Monte Carlo simulation toolkit is used for the implementation of realistic PET simulations incorporating tumor heterogeneous activity distributions. The reconstructed patient images include noise from the acquisition process, imaging system's performance restrictions and have limited spatial resolution. For those reasons, the measured intensity cannot be simply introduced in GATE simulations, to reproduce clinical data. Investigation of the heterogeneity distribution within tumors applying partial volume correction (PVC) algorithms was assessed. The purpose of the present study was to create a simulated oncology database based on clinical data with realistic intratumor uptake heterogeneity properties.Methods: PET/CT data of seven oncology patients were used in order to create a realistic tumor database investigating the heterogeneity activity distribution of the simulated tumors. The anthropomorphic models (NURBS based cardiac torso and Zubal phantoms) were adapted to the CT data of each patient, and the activity distribution was extracted from the respective PET data. The patient-specific models were simulated with the Monte Carlo Geant4 application for tomography emission (GATE) in three different levels for each case: (a) using homogeneous activity within the tumor, (b) using heterogeneous activity distribution in every voxel within the tumor as it was extracted from the PET image, and (c) using heterogeneous activity distribution corresponding to the clinical image following PVC. The three different types of simulated data in each case were reconstructed with two iterations and filtered with a 3D Gaussian postfilter, in order to simulate the intratumor heterogeneous uptake. Heterogeneity in all generated images was quantified using textural feature derived parameters in 3D according to the ground truth of the simulation, and compared to clinical measurements. Finally, profiles were plotted in central slices of the tumors, across lines with

  12. Reactor-produced therapeutic radioisotopes

    International Nuclear Information System (INIS)

    Knapp, F.F. Jr.

    2002-01-01

    The significant worldwide increase in therapeutic radioisotope applications in nuclear medicine, oncology and interventional cardiology requires the dependable production of sufficient levels of radioisotopes for these applications (Reba, 2000; J. Nucl. Med., 1998; Nuclear News, 1999; Adelstein and Manning, 1994). The issues associated with both accelerator- and reactor-production of therapeutic radioisotopes is important. Clinical applications of therapeutic radioisotopes include the use of both sealed sources and unsealed radiopharmaceutical sources. Targeted radiopharmaceutical agents include those for cancer therapy and palliation of bone pain from metastatic disease, ablation of bone marrow prior to stem cell transplantation, treatment modalities for mono and oligo- and polyarthritis, for cancer therapy (including brachytherapy) and for the inhibition of the hyperplastic response following coronary angioplasty and other interventional procedures (For example, see Volkert and Hoffman, 1999). Sealed sources involve the use of radiolabeled devices for cancer therapy (brachytherapy) and also for the inhibition of the hyperplasia which is often encountered after angioplasty, especially with the exponential increase in the use of coronary stents and stents for the peripheral vasculature and other anatomical applications. Since neutron-rich radioisotopes often decay by beta decay or decay to beta-emitting daughter radioisotopes which serve as the basis for radionuclide generator systems, reactors are expected to play an increasingly important role for the production of a large variety of therapeutic radioisotopes required for these and other developing therapeutic applications. Because of the importance of the availability of reactor-produced radioisotopes for these applications, an understanding of the contribution of neutron spectra for radioisotope production and determination of those cross sections which have not yet been established is important. This

  13. Preliminary experience of a three-dimensional, large-field-of-view PET scanner for the localization of partial epilepsy

    International Nuclear Information System (INIS)

    Binns, D.S.; O'Brien, T.J.; Murphy, M.; Cook, M.J.; Hicks, R.J.

    1999-01-01

    Full text: PET scanning is a useful ancillary technique in the localization of intractable partial epilepsy, but its widespread use has been limited by the high cost of traditional PET equipment and radioisotopes. The use of 3D-scanning mode with a large-field of-view PET scanner involves lower equipment costs and requires significantly lower doses of radioisotope. Our aim was to report our preliminary experience of the use of a 3-D, large-field-of-view scanner for FDG-PET studies in the localization of partial epilepsy. 31 patients (pts) with partial epilepsy were studied. The FDG-PET scans were reviewed blindly by a single reviewer without knowledge of seizure localization on structural imaging or ictal electroencephalographic (EEG) monitoring. The PET results were correlated with the localization by more traditional techniques and the results on surgery when available. A localized region of hypometabolism on FDG-PET scanning was reported in 26/31 (84%) patients (21 temporal, 5 extratemporal). This compared favourably with volumetric MRI on which 19/31 (61%) had a focal potentially epileptogenic abnormality, all of which were concordant with the PET localization. PET was concordant with ictal EEG onset in all 22 patients with localizing studies, including 5 pts with normal MRI. PET demonstrated localized hypometabolism in 4/5 pts with non-localizing ictal EEG and was concordant in both pts with abnormal MRI in this group. PET was considered normal in 4 pts, including 3 pts with normal MRI but localizing EEG and 1 pt without EEG or MRI abnormality. One pt with a localizing EEG and normal MRI was felt to have bitemporal hypometabolism. Five patients have subsequently had resective epilepsy surgery with 4 currently seizure-free and 1 significantly improved. Four patients are planned for surgery in the near future. In conclusion, FDG-PET using a 3-D, large-field-of view PET scanner provides sensitive and specific localization in partial epilepsy, and may provide a

  14. New applications of radioisotopes

    International Nuclear Information System (INIS)

    Beddoes, J.M.

    1982-06-01

    The Radiochemical Company of Atomic Energy of Canada Ltd. is developing new uses for radioisotpes. This paper discusses three of them. The first is positron emission tomography. AECL, together with the Montreal Neurological Institute, has developed a new PET scanner, the Therascan 3128. A second area of interest is radiopharmaceuticals, which AECL is beginning to produce in patient-ready form. Finally, investigations are being carried out into the use of cobalt 60 gamma sources as food and waste irradiators

  15. Agricultural application of radioisotopes

    International Nuclear Information System (INIS)

    Agrawal, H.M.

    2001-01-01

    The radiations and isotopic tracers laboratory (R.I.T.L.) is duly approved B-class laboratory for handling radioactivity and functions as a central research facility of our university which has played a very significant role in ushering green revolution in the country. Radiolabelled fertilizers, insecticides and isotopes mostly supplied by Board of Radiation and Isotope Technology, (BRIT) Department of Atomic Energy (DAE) are being used in our university for the last three decades to study the uptake of fertilizers, micro nutrients, photosynthesis and photorespiration studies in different crop plants, soil-water-plant relations and roots activity, pesticides and herbicides mode of action, plants physiology and microbiology. Main emphasis of research so far has been concentrated on the agricultural productivity. The present talk is an attempt to highlight the enormous potential of radioisotopes to evolve better management of crop system for eco-friendly and sustainable agriculture in the next century. (author)

  16. Cardiovascular: radioisotopic angiocardiography

    International Nuclear Information System (INIS)

    Kriss, J.P.

    1975-01-01

    Radioisotopic angiocardiography, performed after the intravenous injection of 99 /sup m/Tc-labeled pertechnetate or albumin, is a simple, rapid, and safe procedure which permits identification and physiologic assessment of a wide variety of congenital and acquired cardiovascular lesions in infants and children. These include atrial and ventricular septal defect, tetralogy of Fallot, pulmonic stenosis, aortopulmonary window, transposition of the great vessels, valvular stenosis and/or insufficiency, myocardial lesions, and lesions of the great vessels. The simplicity of the procedure lends itself to repeated measurements to assess the effects of therapy or to follow the course of the disease. A wide spectrum of congenital and acquired cardiovascular diseases have been studied which have particular application to the pediatric age group. (auth)

  17. Radioisotope production in Malaysia

    Energy Technology Data Exchange (ETDEWEB)

    Wan Awang, Wan Anuar [Medical Technology Div., Malaysian Inst. for Nuclear Technology Research (MINT) (Malaysia)

    1998-10-01

    Production of Mo-99 by neutron activation of Mo-99 in Malaysia began as early as 1984. Regular supply of the Tc-99m extracted from it to the hospitals began in early 1988 after going through formal registration with the Malaysian Ministry of Health. Initially, the weekly demand was about 1.2 Ci of Mo-99 which catered the needs of 3 nuclear medicine centres. Sensitive to the increasing demand of Tc-99m, we have producing our own Tc-99m generator from imported TeO{sub 2} because irradiation TeO{sub 2} with our reactor give low yield of I-131. We have established the production of radioisotope for industrial use. By next year, Sm-153 EDTMP will be produce after we have license from our competent authority. (author)

  18. Radioisotopes in sedimentology

    International Nuclear Information System (INIS)

    Courtois, G.

    1967-01-01

    Radioisotopes have two main uses in sedimentology: they are used for the study of sediment movements in rivers and seas, and for continuous measurements of the amount of sediment suspended in a given medium. These two uses are considered in detail, and brief accounts given of some other uses. Study of sediment movements. After describing the basic technique used in sediment movement studies (injection of a labelled sediment or a simulator into the current, followed by tracking the radioactivity), the author enumerates as fully as possible the problems that can be solved with the help of this technique. Essentially, these problems fall into two groups: 1. Problems related to civil engineering works in coastal areas: the siltation of harbour channels and docks, the formation of banks and bars, the choice of sites for disposing of dredged sediment, the siting of ports, coastline protection, etc. Problems associated with civil engineering works in and near rivers; siting of the water intakes of hydroelectric and nuclear power stations, the effects of construction work on the transport of solids, the construction of dams, the protection of river banks, the construction of jetties, the siltation of lakes, etc. Problems common to these include the transport of effluent and the calibration of hydraulic models. The bibliography is based mainly on fairly recent references and on current research work. 2. Problems related to basic or applied research conducted mainly by universities and research centres: the study of the Quarternary of a particular region, pure sedimentology, the investigation of major sediment transport currents, the confirmation or refutation of transport theories, research into fundamental transport phenomena associated with channel experiments. After referring to the possible exploitation of natural tracers (contained in radioactive waste and fallout), the author discusses the technical aspects of using artificial tracers: the choice of radioisotope

  19. Radio-isotopic tracers

    International Nuclear Information System (INIS)

    Wolfangel, R.G.

    1976-01-01

    The invention concerns the dispersions that may be used for preparing radio-isotopic tracers, technetium labelled dispersions, processes for preparing these dispersions and their use as tracers. Technetium 99m sulphur colloids are utilized as scintillation tracers to give a picture of the reticulo-endothelial system, particularly the liver and spleen. A dispersion is provided which only requires the addition of a radioactive nuclide to form a radioactively labelled dispersion that can be injected as a tracer. It is formed of a colloid of tin sulphur dispersed in an aqueous buffer solution. Such a reagent has the advantage of being safe and reliable and is easier to use. The colloid can be prepared more quickly since additions of several different reagents are avoided. There is no need to heat up and no sulphuretted hydrogen, which is a toxic gas, is used [fr

  20. Generation of radioisotopes

    International Nuclear Information System (INIS)

    Panek-Finda, H.

    1984-01-01

    A method of producing radioisotopes for radiopharmaceutical applications is claimed. A physiological solution is used to elute a radioactive daughter isotope from a fission-produced parent isotope adsorbed on an adsorbent. The eluate containing the daughter isotope is purified with a cation-exchange material. In separate claims: the parent isotope is molybdenum-99; aluminium oxide which contains fully or partly hydrated manganese dioxide is used as the adsorbent for the parent isotope; a resin is used as the cation-exchange material; a strongly acid cation-exchange resin which has been neutralized is used as a resin; and a strongly acid cation-exchange resin which has been converted into the Na + , K + or NH 4 + form is used as a resin; an isotope generator system is also claimed

  1. Status and prospects on radioisotope production in Korea

    International Nuclear Information System (INIS)

    Han, H. S.; Cho, W. K.; Park, U. J.; Hong, Y. D.; Park, K. B.

    2002-01-01

    In Korea, radioisotopes has been produced using small-sized research reactors (TRIGA Mark II, III) from 1961 to 1995. The Korea Atomic Energy Research Institute (KAERI) completed the High-flux Advanced Neutron Application Reactor (HANARO) in 1995 and a radioisotope production facilities (RIPF) in 1997. Medical and industrial radionuclides such as 131 I, 99m Tc, 166 Ho, 192 Ir and 60 Co, are routinely produced utilizing HANARO. Several hundreds kilo curies of these nuclides were supplied to domestic users in 2001. The Korea Cancer Center Hospital (KCCH) first installed a cyclotron (MC-50) for neutron therapy and RI production in 1984. At present, the cyclotron routinely produced radionuclides such as 201 TI, 67 Ga, 123 I and 18 F. Also, it is capable of producing several radionuclides, including 111 In, 51 Cr, 124 I, 54 Mn, 22 Na, etc. Baby cyclotrons were installed in Seoul National University Hospital, Sam sung Medical Center and Asan Medical Center. The main purpose of the introduction of baby cyclotrons was to produce short-lived positron emitters such as 18 F, 15 O and 11 C for PET. Radioisotope production facilities were imported and installed as subsidiaries of cyclotron. In Korea, more than 60 kinds of radioisotopes are currently used in the field of their applications and most of them are imported form foreign vendors. For the quality assurance of final products such as radiopharmaceuticals and industrial sources, facilities for production should be installed and maintained in accordance with regulation rules and also the production system should be operated under quality management system. Since 1992 the Korean government has been encouraging Mid and Long Term Nuclear R and D Programs to enhance capability in nuclear technology development. In order to actively promote the utilization, research and development of technology applying radiation and RI, the Korean government established 'a comprehensive promotion plan for utilization, research and development

  2. Modern radioisotope production technologies for medicine

    International Nuclear Information System (INIS)

    Bechtold, V.; Schweickert, H.

    1989-01-01

    The advantages of the accelerator production of radioisotopes for medical purposes, are, above all, the high specific activity attainable as well as the possibility of the generation of nuclei with only a few neutrons which disintegrate due to β + emission or electron capture. It is, for example, possible to diagnostically utilize the developing long-range γ quanta by means of computerized tomography. The production of I-123 at the cyclotron of Karlsruhe (nuclear reaction, target, irradiation arrangement) as well as of ultra-pure I-123 with the help of compact cyclotrons, and the plant developed for this are described in brief. As another radioisotope which can be produced with the help of the compact cyclotron, Rb-81 is mentioned, the disintegration product Kr-81m of which is used in pulmonary diagnostics. (RB) [de

  3. Impact of Endoscopic Ultrasonography on (18)F-FDG-PET/CT Upfront Towards Patient Specific Esophageal Cancer Treatment

    NARCIS (Netherlands)

    Hulshoff, J. B.; Mul, V. E. M.; de Boer, H. E. M.; Noordzij, W.; Korteweg, T.; van Dullemen, H. M.; Nagengast, W. B.; Oppedijk, V.; Pierie, J. P. E. N.; Plukker, John Th. M.

    INTRODUCTION: In patients with potentially resectable esophageal cancer (EC), the value of endoscopic ultrasonography (EUS) after fluorine-18 labeled fluorodeoxyglucose positron emission tomography with computed tomography ((18)F-FDG-PET/CT) is questionable. Retrospectively, we assessed the impact

  4. Issues specific to implementing PET-CT for pediatric oncology: what we have learned along the way

    International Nuclear Information System (INIS)

    Kaste, S.C.

    2004-01-01

    In parallel with the expansion of PET imaging to pediatric patients has been the technological development of merging state-of-the-art cross-sectional anatomic information (CT) with functional imaging (PET) into a single modality: PET-CT. Attending to the clinical, scheduling, and medical needs that are unique to imaging children and adolescents can be a challenge, particularly when instituting a single new modality. When that modality bridges two unique, previously independent methods-often previously located in two separate departmental divisions-the details and logistics required to set up a smoothly functioning process can be particularly difficult. This paper focuses on our experience in implementing PET-CT in a tertiary pediatric referral center. (orig.)

  5. EXPLORER: Changing the molecular imaging paradigm with total-body PET/CT (Conference Presentation)

    Science.gov (United States)

    Cherry, Simon R.; Badawi, Ramsey D.; Jones, Terry

    2016-04-01

    Positron emission tomography (PET) is the highest sensitivity technique for human whole-body imaging studies. However, current clinical PET scanners do not make full use of the available signal, as they only permit imaging of a 15-25 cm segment of the body at one time. Given the limited sensitive region, whole-body imaging with clinical PET scanners requires relatively long scan times and subjects the patient to higher than necessary radiation doses. The EXPLORER initiative aims to build a 2-meter axial length PET scanner to allow imaging the entire subject at once, capturing nearly the entire available PET signal. EXPLORER will acquire data with ~40-fold greater sensitivity leading to a six-fold increase in reconstructed signal-to-noise ratio for imaging the total body. Alternatively, total-body images with the EXPLORER scanner will be able to be acquired in ~30 seconds or with ~0.15 mSv injected dose, while maintaining current PET image quality. The superior sensitivity will open many new avenues for biomedical research. Specifically for cancer applications, high sensitivity PET will enable detection of smaller lesions. Additionally, greater sensitivity will allow imaging out to 10 half-lives of positron emitting radiotracers. This will enable 1) metabolic ultra-staging with FDG by extending the uptake and clearance time to 3-5 hours to significantly improve contrast and 2) improved kinetic imaging with short-lived radioisotopes such as C-11, crucial for drug development studies. Frequent imaging studies of the same subject to study disease progression or to track response to therapy will be possible with the low dose capabilities of the EXPLORER scanner. The low dose capabilities will also open up new imaging possibilities in pediatrics and adolescents to better study developmental disorders. This talk will review the basis for developing total-body PET, potential applications, and review progress to date in developing EXPLORER, the first total-body PET scanner.

  6. Radioisotope Power Systems Technology Development

    Data.gov (United States)

    National Aeronautics and Space Administration — The goal of the RPS's technology portfolio is to advance performance of radioisotope power systems through new and novel innovations being developed and transitioned...

  7. Radioisotope indicator, type BETA 2

    International Nuclear Information System (INIS)

    Duszanski, M.; Pankow, A.; Skwarczynski, B.

    1975-01-01

    The authors describe a radioisotope indicator, type BETA 2, constructed in the ZKMPW Works to be employed in mines for counting, checking, signalling the presence and positioning of cars, as well as monitoring the state of some other equipment. (author)

  8. Industrial applications of radioisotope tracers

    International Nuclear Information System (INIS)

    Easey, J.F.

    1985-01-01

    Radioisotope tracing techniques are powerful tools for analysing the behaviour of large systems and investigating industrially or economically important processes. The results of radioisotope experiments can yield important information, for example, on parameters such as flow rates, mixing phenomena, flow abnormalities and leaks. Some examples of current AAEC research are described, covering studies on hearth drainage in blast furnaces, flow behaviour in waste-water treatment ponds, and sediment transport in marine environments

  9. Medical application of radioisotopes

    International Nuclear Information System (INIS)

    Choi, Chang Woon; Lim, S. M.; Kim, E. H.

    2000-05-01

    In this project, we studied following subjects: 1. Clinical research for radionuclide therapy 2. Development of in vitro assay method with radioisotope 3. Development of binary therapy; Boron neutron capture therapy and photodynamic therapy 4. Development of diagnostic methods in radionuclide imaging. The results can be applied for the following objectives: 1) Radionuclide therapy will be applied in clinical practice to treat the cancer patients or other diseases in multi-center trial 2) The newly developed monoclonal antibodies and biomolecules can be used in biology, chemistry or other basic life science research 3) The new methods for the analysis of therapeutic effects, such as dosimetry, and quantitative analysis methods of radioactivity, can be applied in basic research, such as radiation oncology and radiation biology 4) The result of the project will be expected to develop the new radioimmunoassay for drug monitoring following the clinical experiments 5) Boron porphyrin has been successfully labeled with iodine. This enables the pharmacodynamic study of the boron compound in human body 6) A method to evaluate the biological effect of neutrons on tumor cells has been developed 7) The establishment of macro- and microscopic dose assessment using alpha-track autoradiography 8) Clinical application of PDT in bladder cancers, oropharyngeal cancer and skin cancer 9) Radionuclide imaging of estrogen receptor in breast cancer, lipid metabolism, gene therapy, cancers, brain function and heart disease

  10. Radioisotope waste processing systems

    International Nuclear Information System (INIS)

    Machida, Tadashi

    1978-01-01

    The Atomic Energy Safety Bureau established the policy entitled ''On Common Processing System of Radioactive Wastes'' consulting with the Liaison Committee of Radioactive Waste Processing. Japan Atomic Energy Research Institute (JAERI) and Japan Radioisotope Association (JRIA) had been discussing the problems required for the establishment of the common disposal facilities based on the above policy, and they started the organization in spring, 1978. It is a foundation borrowing equipments from JAERI though installing newly some of them not available from JAERI, and depending the fund on JRIA. The operation expenses will be borne by those who want to dispose the wastes produced. The staffs are sent out from JAERI and JRIA. For animal wastes contaminated with RI, formaldehyde dipping should be abolished, but drying and freezing procedures will be taken before they are burnt up in a newly planned exclusive furnace with disposing capacity of 50 kg/hour. To settle the problems of other wastes, enough understanding and cooperation of users are to be requested. (Kobatake, H.)

  11. Medical application of radioisotopes

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chang Woon; Lim, S M; Kim, E H [and others

    2000-05-01

    In this project, we studied following subjects: 1. Clinical research for radionuclide therapy 2. Development of in vitro assay method with radioisotope 3. Development of binary therapy; Boron neutron capture therapy and photodynamic therapy 4. Development of diagnostic methods in radionuclide imaging. The results can be applied for the following objectives: (1) Radionuclide therapy will be applied in clinical practice to treat the cancer patients or other diseases in multi-center trial (2) The newly developed monoclonal antibodies and biomolecules can be used in biology, chemistry or other basic life science research (3) The new methods for the analysis of therapeutic effects, such as dosimetry, and quantitative analysis methods of radioactivity, can be applied in basic research, such as radiation oncology and radiation biology (4) The result of the project will be expected to develop the new radioimmunoassay for drug monitoring following the clinical experiments (5) Boron porphyrin has been successfully labeled with iodine. This enables the pharmacodynamic study of the boron compound in human body (6) A method to evaluate the biological effect of neutrons on tumor cells has been developed (7) The establishment of macro- and microscopic dose assessment using alpha-track autoradiography (8) Clinical application of PDT in bladder cancers, oropharyngeal cancer and skin cancer (9) Radionuclide imaging of estrogen receptor in breast cancer, lipid metabolism, gene therapy, cancers, brain function and heart disease.

  12. Radioisotope labelling of several major insect pest

    International Nuclear Information System (INIS)

    Sutrisno, Singgih

    1981-01-01

    Radioisotope uptake by insects could take place through various parts i.e. mouth, cuticula, intersegmental, secretion and excretion organs. Usually insects are labelled internally by feeding them on an artificial diet containing radioisotope solution. Labelling of several insect pests of cabbage (Crocidolomia binotalis) Zell and Plutella maculipennis Curt and rice (Chilo suppressalis Walker) by dipping of the pupae in 32 P solution showed a promising result. Pupae of Crocidolomia binotalis Zell dipped in 3 ml solution of 32 P with specific activities of 1, 3, 5 and 7 μCi/ml had developed labelled adults of sufficiently high radioactivity levels for ecological studies. Similar results were also obtained with Plutella maculipennis Curt and Chilo suppressalis Walker with doses of 1, 3, 5, 7 and 9 μCi/ml 32 P solution. The best doses for radioisotope labelling by dipping of the insects Crocidolomia binotalis Zell, Plutella maculipennis Curt, and Chilo suppressalis Walker were 1, 9, and 7 μCi/ml respectivelly. (author)

  13. Artificial radioisotopes in food chains

    International Nuclear Information System (INIS)

    Binnerts, W.T.; Faber, K.; Klijn, N.; Lemmens, C.; Wissink, M.

    1986-01-01

    Use of uranium for nuclear fission involves the risk of environmental contamination by radiation during the processes of mining, concentration, peaceful and military application and storage, reprocessing and waste disposal. Three of the most dangerous radioisotopes have been followed here as they move through four different food chains. The main bottlenecks for fast and massive transfer are for 131 I its rather short half life, for 137 Cs the defective plant uptake from soil (and much less so also the pathway through the animal body), and for 90 Sr its discrimination relative to calcium in several transport processes in the animal body, and its preference for the bone mass. Hence it is often of advantage for man to use animals as an additional food chain. Known exceptions are discussed: the reindeer and karibou living entirely on lichens during the winter and thereby acquiring for 137 Cs nearly identical specific activity as plant food, and cow's milk for iodine during a short period after contamination. 15 refs.; 1 figure; 4 tabs

  14. Medical Radioisotope Data Survey: 2002 Preliminary Results

    Energy Technology Data Exchange (ETDEWEB)

    Siciliano, Edward R.

    2004-06-23

    A limited, but accurate amount of detailed information about the radioactive isotopes used in the U.S. for medical procedures was collected from a local hospital and from a recent report on the U.S. Radiopharmaceutical Markets. These data included the total number of procedures, the specific types of procedures, the specific radioisotopes used in these procedures, and the dosage administered per procedure. The information from these sources was compiled, assessed, pruned, and then merged into a single, comprehensive and consistent set of results presented in this report. (PIET-43471-TM-197)

  15. Radiosynthesis and initial characterization of a PDE10A specific PET tracer [18 F]AMG 580 in non-human primates

    International Nuclear Information System (INIS)

    Hwang, Dah-Ren; Hu, Essa; Allen, Jennifer R.; Davis, Carl; Treanor, James; Miller, Silke; Chen, Hang; Shi, Bingzhi; Narayanan, Tanjorie K.; Barret, Olivier; Alagille, David; Yu, Zhigang; Slifstein, Mark

    2015-01-01

    Introduction: Phosphodiesterase 10A (PDE10A) is an intracellular enzyme responsible for the breakdown of cyclic nucleotides which are important second messengers for neurotransmission. Inhibition of PDE10A has been identified as a potential target for treatment of various neuropsychiatric disorders. To assist drug development, we have identified a selective PDE10A positron emission tomography (PET) tracer, AMG 580. We describe here the radiosynthesis of [ 18 F]AMG 580 and in vitro and in vivo characterization results. Methods: The potency and selectivity were determined by in vitro assay using [ 3 H]AMG 580 and baboon brain tissues. [ 18 F]AMG 580 was prepared by a 1-step [ 18 F]fluorination procedure. Dynamic brain PET scans were performed in non-human primates. Regions-of-interest were defined on individuals’ MRIs and transferred to the co-registered PET images. Data were analyzed using two tissue compartment analysis (2TC), Logan graphical (Logan) analysis with metabolite-corrected input function and the simplified reference tissue model (SRTM) method. A PDE10A inhibitor and unlabeled AMG 580 were used to demonstrate the PDE10A specificity. K D was estimated by Scatchard analysis of high and low affinity PET scans. Results: AMG 580 has an in vitro K D of 71.9 pM. Autoradiography showed specific uptake in striatum. Mean activity of 121 ± 18 MBq was used in PET studies. In Rhesus, the baseline BP ND for putamen and caudate was 3.38 and 2.34, respectively, via 2TC, and 3.16, 2.34 via Logan, and 2.92, and 2.01 via SRTM. A dose dependent decrease of BP ND was observed by the pre-treatment with a PDE10A inhibitor. In baboons, 0.24 mg/kg dose of AMG 580 resulted in about 70% decrease of BP ND . The in vivo K D of [ 18 F]AMG 580 was estimated to be around 0.44 nM in baboons. Conclusion: [ 18 F]AMG 580 is a selective and potent PDE10A PET tracer with excellent specific striatal binding in non-human primates. It warrants further evaluation in humans

  16. PET imaging in multiple sclerosis

    NARCIS (Netherlands)

    Faria, Daniele de Paula; Copray, Sjef; Buchpiguel, Carlos; Dierckx, Rudi; de Vries, Erik

    Positron emission tomography (PET) is a non-invasive technique for quantitative imaging of biochemical and physiological processes in animals and humans. PET uses probes labeled with a radioactive isotope, called PET tracers, which can bind to or be converted by a specific biological target and thus

  17. A systematic review of PET and PET/CT in oncology: A way to personalize cancer treatment in a cost-effective manner?

    Directory of Open Access Journals (Sweden)

    Langer Astrid

    2010-10-01

    Full Text Available Abstract Background A number of diagnostic tests are required for the detection and management of cancer. Most imaging modalities such as computerized tomography (CT are anatomical. However, positron emission tomography (PET is a functional diagnostic imaging technique using compounds labelled with positron-emitting radioisotopes to measure cell metabolism. It has been a useful tool in studying soft tissues such as the brain, cardiovascular system, and cancer. The aim of this systematic review is to critically summarize the health economic evidence of oncologic PET in the literature. Methods Eight electronic databases were searched from 2005 until February 2010 to identify economic evaluation studies not included in previous Health Technology Assessment (HTA reports. Only full health economic evaluations in English, French, or German were considered for inclusion. Economic evaluations were appraised using published quality criteria for assessing the quality of decision-analytic models. Given the variety of methods used in the health economic evaluations, the economic evidence has been summarized in qualitative form. Results From this new search, 14 publications were identified that met the inclusion criteria. All publications were decision-analytic models and evaluated PET using Fluorodeoxyglucose F18 (FDG-PET. Eight publications were cost-effectiveness analyses; six were cost-utility analyses. The studies were from Australia, Belgium, Canada, France, Italy, Taiwan, Japan, the Netherlands, the United Kingdom, and the United States. In the base case analyses of these studies, cost-effectiveness results ranged from dominated to dominant. The methodology of the economic evaluations was of varying quality. Cost-effectiveness was primarily influenced by the cost of PET, the specificity of PET, and the risk of malignancy. Conclusions Owing to improved care and less exposure to ineffective treatments, personalized medicine using PET may be cost

  18. Early lesion-specific 18F-FDG PET response to chemotherapy predicts time to lesion progression in locally advanced non-small cell lung cancer

    DEFF Research Database (Denmark)

    Nygård, Lotte; Vogelius, Ivan Richter; Fischer, Barbara M

    2016-01-01

    BACKGROUND AND PURPOSE: We hypothesize that the lesion-to-lesion variability in FDG-PET response after one cycle of chemotherapy for NSCLC in an individual patient may inform radiation dose redistribution. To test this hypothesis, we investigate if time to lesion-progression in patients with mult...... patient response involves a loss of biological information on heterogeneity between lesions. Poor lesion-specific response after one cycle chemotherapy may identify lesions that would benefit from an individualized radiotherapy strategy.......BACKGROUND AND PURPOSE: We hypothesize that the lesion-to-lesion variability in FDG-PET response after one cycle of chemotherapy for NSCLC in an individual patient may inform radiation dose redistribution. To test this hypothesis, we investigate if time to lesion-progression in patients...... with multiple lesions is dependent on lesion-specific response to chemotherapy. MATERIALS AND METHODS: We analyzed 81 patients with 184 lesions referred to curative chemo-radiotherapy for NSCLC 2010-2012. (18)F-FDG PET scans were performed at diagnosis and after one series of chemotherapy. Response of each...

  19. A Survey on the Usage and Demand of Medical Radioisotope and Radiopharmaceuticals in Malaysia

    International Nuclear Information System (INIS)

    Muhammad Fakhrurazi Ahmad Fadzil; Siti Selina Abdul Hamid; Siti Najila Mohd Janib; Azahari Kasbollah; Syed Asraf Fahlawi Wafa

    2015-01-01

    Medical radioisotope is a small quantity of radioactive substance used in safe, cost effective, for the purpose of diagnostic and therapy of various diseases. In Malaysia, the emerging of new nuclear medicine centers or institutions in both government and private sectors rose abruptly for the past few years. Currently, there are no data available on the usage and demand of medical radioisotope or radiopharmaceuticals. Understanding the usage trending and demand of radiopharmaceuticals and medical radioisotope is essential when related to technology changes in order to meet the market size of these radiopharmaceuticals. Survey result found out that the highest demand and the highest usage among all radioisotopes are Technetium-99m and Radioiodine isotopes such as the Iodine-1331, Iodine131 MIBG, Iodine-123 and Iodine-123 MIBG. Currently, most of the medical isotopes and radiopharmaceuticals are currently imported. Technetium-99m is the backbone of nuclear medicine whereby more than 80 % of Nuclear Medicine services utilize this radioisotope. Technetium-99m supply chain is unstable globally and in coming future, two main reactors (Canada and Holland) that produces 60 % of world Molybdenum-99 will shut down the operation and supply of Molybdenum-99 will be disrupted. As for radioiodine services, currently, Iodine-123 can't be obtained in Malaysia and neighboring countries due to its short half-life, Iodine-123 is useful in diagnostic of thyroid related diseases. As for PET services, the highest demands are F-18 FDG and Gallium-68 Generator for the moment. However the survey data still did not include most of the PET centers in the Klang Valley, northern area (Penang) and the new upcoming PET center in Southern Region (Malacca and Johor). It is important for Malaysia to self-produced medical radioisotope and radiopharmaceuticals to meet the market and local demand of these medical isotopes. (author)

  20. Radioisotope production in fusion reactors

    International Nuclear Information System (INIS)

    Engholm, B.A.; Cheng, E.T.; Schultz, K.R.

    1986-01-01

    Radioisotope production in fusion reactors is being investigated as part of the Fusion Applications and Market Evaluation (FAME) study. /sup 60/Co is the most promising such product identified to date, since the /sup 60/Co demand for medical and food sterilization is strong and the potential output from a fusion reactor is high. Some of the other radioisotopes considered are /sup 99/Tc, /sup 131/l, several Eu isotopes, and /sup 210/Po. Among the stable isotopes of interest are /sup 197/Au, /sup 103/Rh and Os. In all cases, heat or electricity can be co-produced from the fusion reactor, with overall attractive economics

  1. Radioisotope techniques in oil wells

    International Nuclear Information System (INIS)

    Jain, Prabuddha

    1998-01-01

    Radioisotope techniques are quite useful in oil exploration and exploitation. Nuclear logging offers a way of gathering information on porosity, permeability, fluid saturations, hydrocarbon types and lithology. Some of the interesting applications in well drilling are determining depth of filtrate invasion, detection of lost circulation, drill-bit erosion control; primary cement measurements and well completions such as permanent tubular markers, perforation position marking, detection of channeling behind casing and gravel pack operations. Radioisotopes have been successfully used in optimizing production processes such as production profiling injection profiling, corrosion measurements and well to well tracer tests. (author)

  2. Radioisotope-powered photovoltaic generator

    International Nuclear Information System (INIS)

    McKlveen, J.W.; Uselman, J.

    1979-01-01

    Disposing of radioactive wastes from nuclear power plants has become one of the most important issues facing the nuclear industry. In a new concept, called a radioisotope photovoltaic generator, a portion of this waste would be used in conjunction with a scintillation material to produce light, with subsequent conversion into electricity via photovoltaic cells. Three types of scintillators and two types of silicon cells were tested in six combinations using 32 P as the radioisotope. The highest system efficiency, determined to be 0.5% when the light intensity was normalized to 100 mW/cm 2 , was obtained using a CsI crystal scintillator and a Helios photovoltaic cell

  3. Prospective trial evaluating the sensitivity and specificity of 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine (18F-DOPA) PET and MRI in patients with recurrent gliomas.

    Science.gov (United States)

    Youland, Ryan S; Pafundi, Deanna H; Brinkmann, Debra H; Lowe, Val J; Morris, Jonathan M; Kemp, Bradley J; Hunt, Christopher H; Giannini, Caterina; Parney, Ian F; Laack, Nadia N

    2018-05-01

    Treatment-related changes can be difficult to differentiate from progressive glioma using MRI with contrast (CE). The purpose of this study is to compare the sensitivity and specificity of 18F-DOPA-PET and MRI in patients with recurrent glioma. Thirteen patients with MRI findings suspicious for recurrent glioma were prospectively enrolled and underwent 18F-DOPA-PET and MRI for neurosurgical planning. Stereotactic biopsies were obtained from regions of concordant and discordant PET and MRI CE, all within regions of T2/FLAIR signal hyperintensity. The sensitivity and specificity of 18F-DOPA-PET and CE were calculated based on histopathologic analysis. Receiver operating characteristic curve analysis revealed optimal tumor to normal (T/N) and SUVmax thresholds. In the 37 specimens obtained, 51% exhibited MRI contrast enhancement (M+) and 78% demonstrated 18F-DOPA-PET avidity (P+). Imaging characteristics included M-P- in 16%, M-P+ in 32%, M+P+ in 46% and M+P- in 5%. Histopathologic review of biopsies revealed grade II components in 16%, grade III in 43%, grade IV in 30% and no tumor in 11%. MRI CE sensitivity for recurrent tumor was 52% and specificity was 50%. PET sensitivity for tumor was 82% and specificity was 50%. A T/N threshold > 2.0 altered sensitivity to 76% and specificity to 100% and SUVmax > 1.36 improved sensitivity and specificity to 94 and 75%, respectively. 18F-DOPA-PET can provide increased sensitivity and specificity compared with MRI CE for visualizing the spatial distribution of recurrent gliomas. Future studies will incorporate 18F-DOPA-PET into re-irradiation target volume delineation for RT planning.

  4. Economical and technical feasibility study of some radioisotopes production for medical application

    International Nuclear Information System (INIS)

    Souza, A.L.A.B. de.

    1985-01-01

    The economical and technical feasibility study of the production in reactors of some radioisotopes most used in medicine, are presented. The clinical applications of each radioisotope as well as its radioactive concentrations and specific activities are related. Irradiation procedures based in the foregoing data are given. Part of the study is dedicated to quality control. (M.A.C.) [pt

  5. High specific radioactivity (1R,2S)-4-[18F]fluorometaraminol: a PET radiotracer for mapping sympathetic nerves of the heart

    International Nuclear Information System (INIS)

    Langer, Oliver; Valette, Heric; Dolle, Frederic; Halldin, Christer; Loc'h, Christian; Fuseau, Chantal; Coulon, Christine; Ottaviani, Michele; Bottlaender, Michel; Maziere, Bernard; Crouzel, Christian

    2000-01-01

    The radiolabeled catecholamine analogue (1R,2S)-6-[ 18 F]fluorometaraminol (6-[ 18 F]FMR) is a substrate for the neuronal norepinephrine transporter. It has been used as a positron emission tomography (PET) ligand to map sympathetic nerves in dog heart. 6-[ 18 F]FMR could be only synthesized with low specific radioactivity, which precluded its use in human subjects. We have recently prepared (1R,2S)-4-[ 18 F]fluorometaraminol (4-[ 18 F]FMR), a new fluoro-analogue of metaraminol, with high specific radioactivity (56-106 GBq/μmol). In the present study, we demonstrate in rats that 4-[ 18 F]FMR possesses similar affinity toward myocardial norepinephrine transport mechanisms as 6-[ 18 F]FMR. When compared with control animals, an 80% and 76% reduction in myocardial uptake was observed in animals pretreated with desipramine (an inhibitor of the neuronal norepinephrine transporter) and with reserpine (a blocker of the vesicular storage of monoamines), respectively. The entire radioactivity in rat myocardium represented unmetabolized parent tracer as determined by high performance liquid chromatography analysis of tissue extracts. In dogs, myocardial kinetics of 4-[ 18 F]FMR were assessed using PET. A rapid and high uptake was observed, followed by prolonged cardiac retention. A heart-to-lung ratio of 15 was reached 10 min after injection of the radiotracer. Pretreatment with desipramine reduced the heart half-life of 4-[ 18 F]FMR by 90% compared with control. Moreover, an infusion of tyramine caused a rapid decline of radioactivity in the heart. This demonstrates that 4-[ 18 F]FMR specifically visualizes sympathetic neurons in dog heart. High specific radioactivity 4-[ 18 F]FMR is a promising alternative to 6-[ 18 F]FMR for myocardial neuronal mapping with PET in humans

  6. High specific radioactivity (1R,2S)-4-[{sup 18}F]fluorometaraminol: a PET radiotracer for mapping sympathetic nerves of the heart

    Energy Technology Data Exchange (ETDEWEB)

    Langer, Oliver; Valette, Heric; Dolle, Frederic E-mail: dolle@dsvidf.cea.fr; Halldin, Christer; Loc' h, Christian; Fuseau, Chantal; Coulon, Christine; Ottaviani, Michele; Bottlaender, Michel; Maziere, Bernard; Crouzel, Christian

    2000-04-01

    The radiolabeled catecholamine analogue (1R,2S)-6-[{sup 18}F]fluorometaraminol (6-[{sup 18}F]FMR) is a substrate for the neuronal norepinephrine transporter. It has been used as a positron emission tomography (PET) ligand to map sympathetic nerves in dog heart. 6-[{sup 18}F]FMR could be only synthesized with low specific radioactivity, which precluded its use in human subjects. We have recently prepared (1R,2S)-4-[{sup 18}F]fluorometaraminol (4-[{sup 18}F]FMR), a new fluoro-analogue of metaraminol, with high specific radioactivity (56-106 GBq/{mu}mol). In the present study, we demonstrate in rats that 4-[{sup 18}F]FMR possesses similar affinity toward myocardial norepinephrine transport mechanisms as 6-[{sup 18}F]FMR. When compared with control animals, an 80% and 76% reduction in myocardial uptake was observed in animals pretreated with desipramine (an inhibitor of the neuronal norepinephrine transporter) and with reserpine (a blocker of the vesicular storage of monoamines), respectively. The entire radioactivity in rat myocardium represented unmetabolized parent tracer as determined by high performance liquid chromatography analysis of tissue extracts. In dogs, myocardial kinetics of 4-[{sup 18}F]FMR were assessed using PET. A rapid and high uptake was observed, followed by prolonged cardiac retention. A heart-to-lung ratio of 15 was reached 10 min after injection of the radiotracer. Pretreatment with desipramine reduced the heart half-life of 4-[{sup 18}F]FMR by 90% compared with control. Moreover, an infusion of tyramine caused a rapid decline of radioactivity in the heart. This demonstrates that 4-[{sup 18}F]FMR specifically visualizes sympathetic neurons in dog heart. High specific radioactivity 4-[{sup 18}F]FMR is a promising alternative to 6-[{sup 18}F]FMR for myocardial neuronal mapping with PET in humans.

  7. Radioisotope detection and dating with accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Mast, T S; Muller, R A [California Univ., Berkeley (USA). Lawrence Berkeley Lab.

    1980-07-01

    The status of the new technique of high energy mass spectrometry is reviewed. This sensitive method of measuring isotope concentrations has been applied to the detection of rare radioisotopes used for age estimation. The techniques used to select and identify the individual radioisotope atoms in a sample are described and then the status of the radioisotope measurements and their applications is reviewed.

  8. Prospect of radioisotopes and radiation utilization

    International Nuclear Information System (INIS)

    Tabata, Yoneho

    1994-01-01

    Radiation Utilization in Japan has been positioned, together with nuclear power generation, as one of the important cornerstones, and research and development and practical usage of it has been proceeded with steadily in the fields of industry, agriculture, medicine, and so on. In the field of medicine, SPECT and PET facilities, radio-immunoassay, radiotherapy has come widely to practical use. In the field of agriculture and fisheries, improvement of breed, sterile insect technique have been implemented, and eradication of melon fly has been achieved. In the field of industry, it is expected that the practical use of neutron radiography technique and research and development of synthesizing high performance, high function materials are progressed. In the environment preservation area, a pilot test using electron beam to treat the exhaust gases out of coal fired power plants, city garbages combustion facilities, city high way tunnels in order to establish de- sulphur/de-nitrogen technique is carried out. As the international contribution in the field of radiation utilization, the cooperation with developing countries and the cooperation among advanced countries are reported. In this paper, a prospect of radioisotopes and radiation utilization is described. (J.P.N.)

  9. Radioisotopes for diagnosis and treatment: recent trends and path forward

    International Nuclear Information System (INIS)

    Dash, Ashutosh

    2016-01-01

    Radioisotopes play a significant and indispensable role in studying and understanding biological processes, viewing internal biological structures and processes for diagnosis of abnormal conditions, and in cure and alleviation of sufferings of cancer patients. With the availability of large number of diagnostic agents, SPECT and PET are matured technologies and is the mainstay of functional diagnostic imaging. Treatment of cancer with radioisotopes provides effective cure and the palliation of intractable symptoms. In a country like India, where more than 70% patients present in advanced and inoperable stages, radiation therapy plays an important role. While PET has seen the maximum growth in the last 15 years, next phase of growth of nuclear medicine is expected to be in radionuclide therapy. The new imaging modalities that appeared on the market at this very beginning of the new century and the new molecules and therapeutic technologies associated to the radioactivity open a very encouraging window that fascinates experts from other medical disciplines, and more particularly the oncologists, the hematologists and the neurologists. Cancer treatment remains at the forefront of any new therapeutic modality

  10. Impact of Endoscopic Ultrasonography on 18F-FDG-PET/CT Upfront Towards Patient Specific Esophageal Cancer Treatment.

    Science.gov (United States)

    Hulshoff, J B; Mul, V E M; de Boer, H E M; Noordzij, W; Korteweg, T; van Dullemen, H M; Nagengast, W B; Oppedijk, V; Pierie, J P E N; Plukker, John Th M

    2017-07-01

    In patients with potentially resectable esophageal cancer (EC), the value of endoscopic ultrasonography (EUS) after fluorine-18 labeled fluorodeoxyglucose positron emission tomography with computed tomography ( 18 F-FDG-PET/CT) is questionable. Retrospectively, we assessed the impact of EUS after PET/CT on the given treatment in EC patients. During the period 2009-2015, 318 EC patients were staged as T1-4aN0-3M0 with hybrid 18 F-FDG-PET/CT or 18 F-FDG-PET with CT and EUS if applicable in a nonspecific order. We determined the impact of EUS on the given treatment in 279 patients who also were staged with EUS. EUS had clinical consequences if it changed curability, extent of radiation fields or lymph node resection (AJCC stations 2-5), and when the performed fine-needle aspiration (FNA) provided conclusive information of suspicious lymph node. EUS had an impact in 80 (28.7%) patients; it changed the radiation field in 63 (22.6%), curability in 5 (1.8%), lymphadenectomy in 48 (17.2%), and FNA was additional in 21 (7.5%). In patients treated with nCRT (n = 194), EUS influenced treatment in 53 (27.3%) patients; in 38 (19.6%) the radiation field changed, in 3 (1.5%) the curability, in 35 (18.0%) the lymphadenectomy, and in 17 (8.8%) FNA was additional. EUS influenced both the extent of radiation field and nodal resection in 31 (16.0%) nCRT patients. EUS had an impact on the given treatment in approximately 29%. In most patients, the magnitude of EUS found expression in the extent of radiotherapy target volume delineation to upper/high mediastinal lymph nodes.

  11. Radioisotope study of Eustachian tube

    International Nuclear Information System (INIS)

    De Rossi, G.; Campioni, P.; Vaccaro, A.

    1988-01-01

    Radioisotope studies of Eustachian tube are suggested in the preoperative phase of tympanoplasty, in order to assess tubal drainage and secretion. The use of gamma camera fitted to a computer allowed the AA, to calculate some semi-quantitative parameters for an exact assessment of the radioactivity transit from the tympanic cass up to the pharyngeal cavity, throughout the Eustachian tube. (orig.) [de

  12. Radioisotopes in engineering and industry

    International Nuclear Information System (INIS)

    Castagnet, A.C.G.

    1986-01-01

    The applications of radioisotope techniques in engineering and materials quality control are shown. The inventory of mercury in electrolytical cells, the transit and residence time measurements in several processes and radiotracer control are studied. The radioactive tracers in hydrologycal problems is evaluated. (M.J.C.) [pt

  13. Radioisotopes point the way ahead

    International Nuclear Information System (INIS)

    Evans, E.A.; Oldham, K.G.

    1988-01-01

    The use of radiochemicals as tracers in medicine is discussed, with particular reference to the choice of radioisotope to be used, its properties, quality control and its detection and measurement in tracer experiments. The development of autoradiography is discussed. (U.K.)

  14. Uses of radioisotopes in Sudan

    International Nuclear Information System (INIS)

    Elradi, E. A. M.

    2013-07-01

    In this research project, an inventory for the different radioisotopes that were imported by public and private sectors of Sudan in the period between ( 2007-2011) has been set up. These organizations import the appropriates for different but in general we classify them into these applications: Medical, Industrial, Agricultural and Research. However, each broad discipline is subdivided into subgroups. This inventory will help those who are willing to establish research reactors in Sudan on the type and power of the reactors to be purchases according to the actual needs of Sudan with forecasting of the near and for future needs. Also the expenditure that has been spent by these organizations have been estimated for most of the radioisotopes. It was observed that almost 50% of the expenditure went for the fright charges as these radioisotopes need special handling and care by installing a research reactor in Sudan, the cost of purchasing will be cut down several folds. Also it will help in availability of the radioisotopes with very short half lives (hours to days). This will be reflected in the cut down the cost of tests and provision of new tests.(Author)

  15. Regional specific binding of [11C]RO 15 1788 to central type benzodiazepine receptors in human brain: quantitative evaluation by PET

    International Nuclear Information System (INIS)

    Pappata, S.; Samson, Y.; Chavoix, C.; Prenant, C.; Maziere, M.; Baron, J.C.

    1988-01-01

    The central type benzodiazepine receptors were studied in 17 healthy human subjects with 11 C-RO 15 1788 and positron emission tomography (PET). The brain regional distribution of the tracer in eight control studies performed after injection of trace doses of 11 C-RO 15 1788 was consistent with that of benzodiazepine receptors. Saturation studies with co-injected cold RO 15 1788 in the remaining subjects showed a dose-dependent decrease of brain radiotracer until full inhibition of specific binding was achieved with doses above 0.1 mg/kg (four studies). Based on the results, a simple method to estimate the specifically bound 11 C-RO 15 1788 regionally in a single PET study is proposed, using the data from the full-saturation studies as a stable estimate of the nondisplaceable radioligand concentration. Using this method, it was found that quasiequilibrium between the estimated specifically bound and nondisplaceable components was achieved at times equal to or longer than 20 min after tracer administration. The validity of this method was partly supported by further results, showing a good agreement between the regional specific binding so calculated and postmortem data of receptor density

  16. Statistical dynamic imaging of RI-labeled tracer from list-mode PET data

    International Nuclear Information System (INIS)

    Tanimoto, Michiaki; Kuroda, Yoshihiro; Oshiro, Osamu; Watabe, Hiroshi; Kuroda, Tomohiro

    2009-01-01

    Positron emission tomography (PET) can be used in physiological analysis to illustrate physiological states by visualizing the accumulation of radioisotope (RI)-labeled tracer in specific organs or tissues. PET obtains spatio-temporal statistics in the form of list-mode data. However, conventional imaging techniques, which sum up list-mode data over a given time period, cannot depict detailed temporal dynamics of the RI-labeled tracer. In this study, a spatio-temporal analysis approach was employed to visualize the temporal flow dynamics of RI-labeled tracer from the obtained list-mode data. Experiments to assess the visualization of simulated RI-labeled tracer dynamics as well as RI-labeled tracer dynamics in a vascular phantom showed that the proposed method successfully depicted detailed temporal flow dynamics that could not be visualized using conventional methods. (author)

  17. Radioisotope methodology course radioprotection aspects

    International Nuclear Information System (INIS)

    Bergoc, R.M.; Caro, R.A.; Menossi, C.A.

    1996-01-01

    The advancement knowledge in molecular and cell biology, biochemistry, medicine and pharmacology, which has taken place during the last 50 years, after World War II finalization, is really outstanding. It can be safely said that this fact is principally due to the application of radioisotope techniques. The research on metabolisms, biodistribution of pharmaceuticals, pharmacodynamics, etc., is mostly carried out by means of techniques employing radioactive materials. Radioisotopes and radiation are frequently used in medicine both as diagnostic and therapeutic tools. The radioimmunoanalysis is today a routine method in endocrinology and in general clinical medicine. The receptor determination and characterization is a steadily growing methodology used in clinical biochemistry, pharmacology and medicine. The use of radiopharmaceuticals and radiation of different origins, for therapeutic purposes, should not be overlooked. For these reasons, the importance to teach radioisotope methodology is steadily growing. This is principally the case for specialization at the post-graduate level but at the pre graduate curriculum it is worthwhile to give some elementary theoretical and practical notions on this subject. These observations are justified by a more than 30 years teaching experience at both levels at the School of Pharmacy and Biochemistry of the University of Buenos Aires, Argentina. In 1960 we began to teach Physics III, an obligatory pregraduate course for biochemistry students, in which some elementary notions of radioactivity and measurement techniques were given. Successive modifications of the biochemistry pregraduate curriculum incorporated radiochemistry as an elective subject and since 1978, radioisotope methodology, as obligatory subject for biochemistry students. This subject is given at the radioisotope laboratory during the first semester of each year and its objective is to provide theoretical and practical knowledge to the biochemistry students, even

  18. Oncology PET imaging

    International Nuclear Information System (INIS)

    Inubushi, Masayuki

    2014-01-01

    At the beginning of this article, likening medical images to 'Where is Waldo?' I indicate the concept of diagnostic process of PET/CT imaging, so that medical physics specialists could understand the role of each imaging modality and infer our distress for image diagnosis. Then, I state the present situation of PET imaging and the basics (e.g. health insurance coverage, clinical significance, principle, protocol, and pitfall) of oncology FDG-PET imaging which accounts for more than 99% of all clinical PET examinations in Japan. Finally, I would like to give a wishful prospect of oncology PET that will expand to be more cancer-specific in order to assess therapeutic effects of emerging molecular targeted drugs targeting the 'hallmarks of cancer'. (author)

  19. Miniaturized radioisotope solid state power sources

    Science.gov (United States)

    Fleurial, J.-P.; Snyder, G. J.; Patel, J.; Herman, J. A.; Caillat, T.; Nesmith, B.; Kolawa, E. A.

    2000-01-01

    Electrical power requirements for the next generation of deep space missions cover a wide range from the kilowatt to the milliwatt. Several of these missions call for the development of compact, low weight, long life, rugged power sources capable of delivering a few milliwatts up to a couple of watts while operating in harsh environments. Advanced solid state thermoelectric microdevices combined with radioisotope heat sources and energy storage devices such as capacitors are ideally suited for these applications. By making use of macroscopic film technology, microgenrators operating across relatively small temperature differences can be conceptualized for a variety of high heat flux or low heat flux heat source configurations. Moreover, by shrinking the size of the thermoelements and increasing their number to several thousands in a single structure, these devices can generate high voltages even at low power outputs that are more compatible with electronic components. Because the miniaturization of state-of-the-art thermoelectric module technology based on Bi2Te3 alloys is limited due to mechanical and manufacturing constraints, we are developing novel microdevices using integrated-circuit type fabrication processes, electrochemical deposition techniques and high thermal conductivity substrate materials. One power source concept is based on several thermoelectric microgenerator modules that are tightly integrated with a 1.1W Radioisotope Heater Unit. Such a system could deliver up to 50mW of electrical power in a small lightweight package of approximately 50 to 60g and 30cm3. An even higher degree of miniaturization and high specific power values (mW/mm3) can be obtained when considering the potential use of radioisotope materials for an alpha-voltaic or a hybrid thermoelectric/alpha-voltaic power source. Some of the technical challenges associated with these concepts are discussed in this paper. .

  20. A Survey on the Usage and Demand of Medical Radioisotope and Radiopharmaceuticals in Malaysia

    International Nuclear Information System (INIS)

    Muhammad Fakhrurazi Ahmad Fadzil; Siti Selina Abdul Hamid; Siti Najila Mohd Janib; Azahari Kasbollah; Syed Asraf Fahlawi Wafa

    2016-01-01

    Medical radioisotope is a small quantity of radioactive substance used for the purpose of diagnostic and therapy of various diseases. In Malaysia, the emerging of new nuclear medicine centers or institutions in both government and private sectors rose abruptly for the past few years. Currently, there are no data available on the usage and demand of these medical radioisotope or radiopharmaceuticals. The aim of this study is to assess current medical radioisotopes and radiopharmaceuticals usage and also to provide data on current medical radioisotope and radiopharmaceuticals demand for both private and government hospitals or institutions in Malaysia. A survey for a period of 3 months was conducted across Malaysia. The survey was divided into five (5) main parts and it was distributed among health care professionals involved working with medical radioisotope and radiopharmaceuticals in private, government and university based hospitals or institutions and was distributed manually either by hand, mail or e-mail. Data is presented in either pie chart or bar chart. Survey results found out that the highest demand and the highest usage among all radioisotopes are Technetium-99m and radioiodine isotopes such as the iodine-131, iodine-131 MIBG, iodine-123 and iodine-123 MIBG. Technetium-99m is the backbone of nuclear medicine whereby more than 80 % of Nuclear Medicine services utilize this radioisotope. Technetium-99m supply chain is unstable globally and in coming future, two main reactors that produce 60 % of world Molybdenum-99 will shut down and the supply of molybdenum-99 will be disrupted. In radioiodine services, currently, Iodine-123 cannot be obtained in Malaysia and neighboring countries due to its short half-life. Iodine-123 is useful in diagnostic of thyroid related diseases. As for PET services, the highest demands are F-18 FDG and gallium-68 Generator. It is important for Malaysia to self-produced medical radioisotope and radiopharmaceuticals to meet the

  1. Present status of OAP radioisotope production

    International Nuclear Information System (INIS)

    Charoen, Sakda

    2006-01-01

    Radioisotope Production Program (RP), Office of Atoms for Peace (OAP) is a non-profit government organization which responsible for research development and service of radioisotopes. Several research works on radioisotope production have been carried on at OAP. The radioisotope products of successful R and D have been routinely produced to supply for medical, agriculture and research application. The main products are 131 I (solution and capsule), 131 I-MIBG, 131 I-Hippuran, 153 Sm-EDTMP, 153 Sm-HA, and 99m Tc-radiopharmaceutical kits to serve local users. Radioisotopes are very beneficial for science and human welfare so as almost of our products and services are mainly utilized for medical purpose for both diagnosis and therapy. OAP has a policy to serve and response to that community by providing radioisotopes and services with high quality but reasonable price. This policy will give the opportunity to the community to utilize these radioisotopes for their healthcare. (author)

  2. Optimization of periodical interrogation of transducers of radioisotope measuring systems

    International Nuclear Information System (INIS)

    Ivashchenko, A.S.; Kaznakov, V.P.; Korolev, V.M.

    1978-01-01

    Certain methods are examined of optimizing periodic interrogation of sensors connected in a definite sequence to device for data processing in a system for controlling production processes. It is shown that in designing multiinput radioisotope measurement systems with a centralized data processing, the choice of the method of organizing periodic interrogation should be made with account for the conditions existing in each specific case

  3. Use of the FLUKA Monte Carlo code for 3D patient-specific dosimetry on PET-CT and SPECT-CT images*

    Science.gov (United States)

    Botta, F; Mairani, A; Hobbs, R F; Vergara Gil, A; Pacilio, M; Parodi, K; Cremonesi, M; Coca Pérez, M A; Di Dia, A; Ferrari, M; Guerriero, F; Battistoni, G; Pedroli, G; Paganelli, G; Torres Aroche, L A; Sgouros, G

    2014-01-01

    Patient-specific absorbed dose calculation for nuclear medicine therapy is a topic of increasing interest. 3D dosimetry at the voxel level is one of the major improvements for the development of more accurate calculation techniques, as compared to the standard dosimetry at the organ level. This study aims to use the FLUKA Monte Carlo code to perform patient-specific 3D dosimetry through direct Monte Carlo simulation on PET-CT and SPECT-CT images. To this aim, dedicated routines were developed in the FLUKA environment. Two sets of simulations were performed on model and phantom images. Firstly, the correct handling of PET and SPECT images was tested under the assumption of homogeneous water medium by comparing FLUKA results with those obtained with the voxel kernel convolution method and with other Monte Carlo-based tools developed to the same purpose (the EGS-based 3D-RD software and the MCNP5-based MCID). Afterwards, the correct integration of the PET/SPECT and CT information was tested, performing direct simulations on PET/CT images for both homogeneous (water) and non-homogeneous (water with air, lung and bone inserts) phantoms. Comparison was performed with the other Monte Carlo tools performing direct simulation as well. The absorbed dose maps were compared at the voxel level. In the case of homogeneous water, by simulating 108 primary particles a 2% average difference with respect to the kernel convolution method was achieved; such difference was lower than the statistical uncertainty affecting the FLUKA results. The agreement with the other tools was within 3–4%, partially ascribable to the differences among the simulation algorithms. Including the CT-based density map, the average difference was always within 4% irrespective of the medium (water, air, bone), except for a maximum 6% value when comparing FLUKA and 3D-RD in air. The results confirmed that the routines were properly developed, opening the way for the use of FLUKA for patient-specific, image

  4. PET-based compartmental modeling of {sup 124}I-A33 antibody: quantitative characterization of patient-specific tumor targeting in colorectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Zanzonico, Pat; O' Donoghue, Joseph A.; Humm, John L. [Memorial Sloan Kettering Cancer Center, Department of Medical Physics, New York, NY (United States); Carrasquillo, Jorge A.; Pandit-Taskar, Neeta; Ruan, Shutian; Larson, Steven M. [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Smith-Jones, Peter [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Stony Brook School of Medicine, Departments of Psychiatry and Radiology, Stony Brook, NY (United States); Divgi, Chaitanya [Columbia University Medical Center, New York, NY (United States); Scott, Andrew M. [La Trobe University, Olivia Newton-John Cancer Research Institute, Melbourne (Australia); Kemeny, Nancy E.; Wong, Douglas; Scheinberg, David [Memorial Sloan Kettering Cancer Center, Department of Medicine, New York, NY (United States); Fong, Yuman [Memorial Sloan Kettering Cancer Center, Department of Surgery, New York, NY (United States); City of Hope, Department of Surgery, Duarte, CA (United States); Ritter, Gerd; Jungbluth, Achem; Old, Lloyd J. [Memorial Sloan Kettering Cancer Center, Ludwig Institute for Cancer Research, New York, NY (United States)

    2015-10-15

    The molecular specificity of monoclonal antibodies (mAbs) directed against tumor antigens has proven effective for targeted therapy of human cancers, as shown by a growing list of successful antibody-based drug products. We describe a novel, nonlinear compartmental model using PET-derived data to determine the ''best-fit'' parameters and model-derived quantities for optimizing biodistribution of intravenously injected {sup 124}I-labeled antitumor antibodies. As an example of this paradigm, quantitative image and kinetic analyses of anti-A33 humanized mAb (also known as ''A33'') were performed in 11 colorectal cancer patients. Serial whole-body PET scans of {sup 124}I-labeled A33 and blood samples were acquired and the resulting tissue time-activity data for each patient were fit to a nonlinear compartmental model using the SAAM II computer code. Excellent agreement was observed between fitted and measured parameters of tumor uptake, ''off-target'' uptake in bowel mucosa, blood clearance, tumor antigen levels, and percent antigen occupancy. This approach should be generally applicable to antibody-antigen systems in human tumors for which the masses of antigen-expressing tumor and of normal tissues can be estimated and for which antibody kinetics can be measured with PET. Ultimately, based on each patient's resulting ''best-fit'' nonlinear model, a patient-specific optimum mAb dose (in micromoles, for example) may be derived. (orig.)

  5. Lung PET scan

    Science.gov (United States)

    ... Chest PET scan; Lung positron emission tomography; PET - chest; PET - lung; PET - tumor imaging; ... Grainger & Allison's Diagnostic Radiology: A Textbook of Medical Imaging . 6th ed. Philadelphia, ...

  6. The radioisotopes and radiations program

    International Nuclear Information System (INIS)

    1982-01-01

    This program of the National Atomic Energy Commission of Argentina refers to the application and production of radionuclides, their compounds and sealed sources. The applications are carried out in the medical, agricultural, cattle raising and industrial areas and in other engineering branches. The sub-program corresponding to the production of radioactive materials includes the production of radioisotopes and of sealed sources, and an engineering service for radioactive materials production and handling facilities. The sub-program of applications is performed through several groups or laboratories in charge of the biological and technological applications, intensive radiation sources, radiation dosimetry and training of personnel or of potential users of radioactive material. Furthermore, several aspects about technology transfer, technical assistance, manpower training courses and scholarships are analyzed. Finally, some legal aspects about the use of radioisotopes and radiations in Argentina are pointed out. (M.E.L.) [es

  7. Some results of radioisotope studies

    Energy Technology Data Exchange (ETDEWEB)

    Isamov, N.N.

    1974-10-01

    The accumulation of radioisotopes by brucellae depends on the consistency of the feed medium on which they are grown. The uptake of P-32 is a factor of 5 to 16 greater, and that of sulfur-35 in the form of sodium sulfate is a factor of 30 to 100 greater when grown on a complex solid agar than in a bouillion solution of the same ingredients. Brucellae are readily tagged with /sup 32/P and /sup 35/S simultaneously. These tagged brucellae were used to study in vitro storage under various temperature regimes. Brucellae actively incorporate iron. The uptake of methionine and cystine tagged with sulfur-35 by brucellae was investigated. Methionine is absorbed directly for the most part by brucellae, while the sulfur-35 in sodium sulfate is primarily transformed to cystine and cysteine. The uptake of various radioisotopes can be used to type various strains of brucellae. Isotopes are used to trace the course of various diseases in animals. (SJR)

  8. Radioisotopes in Burmese agricultural research

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1961-07-15

    The Burmese authorities decided to start a laboratory for the use of radioisotope techniques in agricultural r e search. The laboratory was set up at the Agricultural Research Institute at Gyogon, on the outskirts of Rangoon. Under its technical assistance program, IAEA assigned an expert in the agricultural applications of radioisotopes for this project. Discussions were held with regional representatives of the Food and Agriculture Organization on the best lines of research to be adopted at the laboratory in its early stages. As the most important crop in Burma is rice, a series of experiments were planned for a study of the nutrition of rice, particularly its phosphorus uptake, with special reference to comparative responses on a range of typical paddy soils. The experiments began last year and are being continued.

  9. Use of radioisotopes in Japan

    International Nuclear Information System (INIS)

    Foeldiak, G.

    1974-01-01

    A survey of the following general data on the use of radioisotopes in Japan is given (from the material of the 11th Japan Conference on Radioisotopes): 1. number of the organizations using radioactive isotopes, grouped according to special working fields and instruments; 2. amount of the unsealed sources (Ci) used in the different special working fields in 1971, 4. amount of the sealed sources (Ci) used between 1966 and 1971. 5. number of the institutions using sealed sources, grouped according to special working fields (March, 1972), 6. number of the accelerators applied, grouped according to special working fields (March, 1972), 7. number of the nuclear instruments in the education and research institutes (March, 1972), 8. amount of the collected radioactive waste material between 1960 and 1971 (number of containers). (K.A.)

  10. Rhenium radioisotopes for therapeutic radiopharmaceutical development

    International Nuclear Information System (INIS)

    Knapp, F.F. Jr.; Beets, A.L.; Pinkert, J.; Kropp, J.; Lin, W.Y.; Wang, S.Y.

    2001-01-01

    Rhenium-186 and rhenium-188 represent two important radioisotopes which are of interest for a variety of therapeutic applications in oncology, nuclear medicine and interventional cardiology. Rhenium-186 is directly produced in a nuclear reactor and the 90 hour half-life allows distribution to distant sites. The relatively low specific activity of rhenium-186 produced in most reactors, however, permits use of phosphonates, but limits use for labelled peptides and antibodies. Rhenium-188 has a much shorter 16.9 hour half-life which makes distribution from direct reactor production difficult. However, rhenium-188 can be obtained carrier-free from a tungsten-188/rhenium-188 generator, which has a long useful shelf-life of several months which is cost-effective, especially for developing regions. In this paper we discuss the issues associated with the production of rhenium-186- and rhenium-188 and the development and use of various radiopharmaceuticals and devices labelled with these radioisotopes for bone pain palliation, endoradiotherapy of tumours by selective catheterization and tumour therapy using radiolabelled peptides and antibodies, radionuclide synovectomy and the new field of vascular radiation therapy. (author)

  11. Radioisotope dust pollution monitor

    International Nuclear Information System (INIS)

    Szepke, R.; Harasimczuk, J.; Dobrowiecki, J.

    1990-01-01

    Measuring principles and specification of two dust monitors: station-type AMIZ and portable-type PIK-10 for ambient air pollution are presented. The first one, a fully automatic instrument is destined for permanent monitoring of air pollution in preset sampling time from .25 to 24 hours. The second one was developed as a portable working model. Both instruments display their results in digital form in dust concentration units. (author)

  12. FDG-PET response of skeletal (bone marrow and bone) involvement after induction chemotherapy in pediatric Hodgkin lymphoma - Are specific response criteria required?

    Science.gov (United States)

    Georgi, Thomas Walter; Kluge, Regine; Kurch, Lars; Chavdarova, Lidia; Hasenclever, Dirk; Stoevesandt, Dietrich; Pelz, Tanja; Landman-Parker, Judith; Wallace, Hamish; Karlen, Jonas; Fernandez-Teijeiro, Ana; Cepelova, Michaela; Fossa, Alexander; Balwierz, Walentyna; Attarbaschi, Andishe; Ammann, Roland A; Pears, Jane; Hraskova, Andrea; Uyttebroeck, Anne; Beishuizen, Auke; Dieckmann, Karin; Leblanc, Thierry; Daw, Stephen; Baumann, Julia; Körholz, Dieter; Sabri, Osama; Mauz-Körholz, Christine

    2018-04-13

    Purpose: This study focused on skeletal involvement in FDG-PET (PET) in Hodgkin lymphoma (HL). We aimed at a systematic evaluation of the different types of skeletal involvement and their PET response after two cycles of chemotherapy (PET-2), to answer the question whether the current PET response criterion for skeletal involvement is suitable. A secondary objective was to observe the influence of initial uptake intensity and metabolic tumor volume (MTV) of skeletal lesions on the PET-2 response. Methods: Initial PET scans (PET-0) of 1068 pediatric HL patients from the EuroNet-PHL-C1 (C1) trial were evaluated by central review for skeletal involvement. Three types of skeletal lesions were distinguished: skeletal lesions detected only in PET (PETonly), bone marrow (BM) lesions confirmed by MRI or BM biopsy and bone lesions. Uptake intensity (measured as qPET value) and MTV were calculated for each skeletal lesion. All PET-2 scans were assessed for residual tumor activity. The rates of complete metabolic response in PET-2 of skeletal and nodal involvement were compared. Results: 139/1068 (13%) C1 patients showed skeletal involvement (44/139 PETonly patients, 32/139 BM patients and 63/139 bone patients). 101/139 (73%) patients became PET-2 negative in the skeleton while lymph node involvement was PET-2 negative in 94/139 (68%) patients. Highest skeletal PET-2 negative rate was seen in 42/44 (95%) PETonly patients, followed by 22/32 (69%) BM patients and 37/63 (59%) bone patients. Skeletal lesions who became PET-2 negative showed lower median values for initial qPET (2.74) and MTV (2ml) than lesions who remained PET-2 positive (3.84; 7ml). Conclusion: In this study with pediatric HL patients, the complete response rate in PET-2 of skeletal and nodal involvement was similar. Bone flare seemed to be irrelevant. Overall, the current skeletal PET response criterion - comparison with the local skeletal background - is well suited. Initial uptake intensity and MTV of

  13. Physical aspects of radioisotope brachytherapy

    International Nuclear Information System (INIS)

    1967-01-01

    The present report represents an attempt to provide, within a necessarily limited compass, an authoritative guide to all important physical aspects of the use of sealed gamma sources in radiotherapy. Within the report, reference is made wherever necessary to the more extensive but scattered literature on this subject. While this report attempts to cover all the physical aspects of radioisotope 'brachytherapy' it does not, of course, deal exhaustively with any one part of the subject. 384 refs, 3 figs, 6 tabs

  14. Background current of radioisotope manometer

    International Nuclear Information System (INIS)

    Vydrik, A.A.

    1987-01-01

    The technique for calculating the main component of the background current of radioisotopic monometers, current from direct collision of ionizing particles and a collector, is described. The reasons for appearance of background photoelectron current are clarified. The most effective way of eliminating background current components is collector protection from the source by a screen made of material with a high gamma-quanta absorption coefficient, such as lead, for example

  15. Radioisotopes for therapy: an overview

    International Nuclear Information System (INIS)

    Venkatesh, Meera

    2006-01-01

    Radionuclides made great impact in the history of nuclear sciences both at the end of 19th century with the discoveries of Becquerel and madame Curie and later in 1934, when Frederic Joliet and Irene Curie demonstrated the production of the first artificial radioisotopes, 30 P, by bombardment of 27 Al by alpha particles. The subsequent invention of cyclotron and setting up of nuclear reactor opened the floodgate for production of artificial radionuclides. Currently, majority of radionuclides are made artificially by transforming a stable nuclide into an unstable state and thus far over 2500 radionuclides have been produced artificially. Use of radionuclides in various fields immediately followed their production and last century has witnessed tremendous growth in the applications of radiation and radioisotopes, in diverse fields such as medicine, industry, agriculture, food preservation, water resource management, environmental studies, etc. While radiation and radioisotopes are used both for diagnosis as well as for therapy in the field of medicine, therapeutic applications are among the earliest, which began as an empirical science in the beginning and developed into a well structured modality with time. (author)

  16. Detection of Cancer with PET and PET/CT in Asymptomatic Volunteers

    International Nuclear Information System (INIS)

    Chung, Ji In; Choi, Joon Young; Lee, Kyung Han; Kim, Byung Tae; Choi, Yoon Ho; Cho, Han Byoul; Shim, Jae Yong

    2009-01-01

    We retrospectively investigated the diagnostic performance of 18 F-fluorodeoxyglucose positron emission tomography (PET) and PET/CT for cancer detection in asymptomatic health-check examinees. This study consisted of 5091 PET or PET/CT conducted as part of annual health examination at one hospital from March 1998 to February 2008. To find the incidence of cancers, medical records of the subjects were thoroughly reviewed for a follow-up period of one year. The patterns of formal readings of PET and PET/CT were analyzed to assess the sensitivity and specificity for cancer detection. The histopathology and stage of the cancers were evaluated in relation to the results of PET. Eighty-six cancers (1.7%) were diagnosed within one year after PET or PET/CT. When PET and PET/CT results were combined, the sensitivity was 48.8% and specificity was 81.1% for cancer detection. PET only had a sensitivity of 46.2% and a specificity of 81.4%, and PET/CT only had a sensitivity of 75.0% and a specificity of 78.5% respectively. There were no significant differences in cancer site, stage and histopathology between PET positive and PET negative cancers. In 19.3% of formal readings of PET and PET/CT, further evaluation to exclude malignancy or significant disease was recommended. Head and neck area and upper gastrointestinal tract were commonly recommended sites for further evaluation. PET and PET/CT showed moderate performance for detecting cancers in asymptomatic adults in this study. More experience and further investigation are needed to overcome limitations of PET and PET/CT for cancer screening

  17. Radioisotope and radiopharmaceutical generators

    International Nuclear Information System (INIS)

    Barak, M.; Winchell, H.W.

    1975-01-01

    A chromatographic column for generating technetium-99m isotopes and technetium-99m labeled pharmaceuticals in a simple two-step process is described. Technetium-99m pertechnetate in a first step is isolated by adsorption upon an adsorbent packing. Then the technetium-99m in a second step is eluted from the packing, either with an immediately labeled biological compound to form a radiopharmaceutical, or by a controlled volume of eluant to produce a 99m-technetium-bearing eluate of a desired specific concentration. (Official Gazette)

  18. PET imaging evaluation of [{sup 18}F]DBT-10, a novel radioligand specific to α{sub 7} nicotinic acetylcholine receptors, in nonhuman primates

    Energy Technology Data Exchange (ETDEWEB)

    Hillmer, Ansel T.; Zheng, Ming-Qiang; Li, Songye; Lin, Shu-fei; Holden, Daniel; Labaree, David; Ropchan, Jim; Carson, Richard E.; Huang, Yiyun [Yale University, PET Center, 801 Howard Ave, PO Box 208048, New Haven, CT (United States); Scheunemann, Matthias; Teodoro, Rodrigo; Deuther-Conrad, Winnie; Brust, Peter [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig (Germany)

    2016-03-15

    Positron emission tomography (PET) radioligands specific to α{sub 7} nicotinic acetylcholine receptors (nAChRs) afford in vivo imaging of this receptor for neuropathologies such as Alzheimer's disease, schizophrenia, and substance abuse. This work aims to characterize the kinetic properties of an α{sub 7}-nAChR-specific radioligand, 7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-[{sup 18}F]-fluorodibenzo[b,d]thiophene 5,5-dioxide ([{sup 18}F]DBT-10), in nonhuman primates. [{sup 18}F]DBT-10 was produced via nucleophilic substitution of the nitro-precursor. Four Macaca mulatta subjects were imaged with [{sup 18}F]DBT-10 PET, with measurement of [{sup 18}F]DBT-10 parent concentrations and metabolism in arterial plasma. Baseline PET scans were acquired for all subjects. Following one scan, ex vivo analysis of brain tissue was performed to inspect for radiolabeled metabolites in brain. Three blocking scans with 0.69 and 1.24 mg/kg of the α{sub 7}-nAChR-specific ligand ASEM were also acquired to assess dose-dependent blockade of [{sup 18}F]DBT-10 binding. Kinetic analysis of PET data was performed using the metabolite-corrected input function to calculate the parent fraction corrected total distribution volume (V{sub T}/f{sub P}). [{sup 18}F]DBT-10 was produced within 90 min at high specific activities of 428 ± 436 GBq/μmol at end of synthesis. Metabolism of [{sup 18}F]DBT-10 varied across subjects, stabilizing by 120 min post-injection at parent fractions of 15-55 %. Uptake of [{sup 18}F]DBT-10 in brain occurred rapidly, reaching peak standardized uptake values (SUVs) of 2.9-3.7 within 30 min. The plasma-free fraction was 18.8 ± 3.4 %. No evidence for radiolabeled [{sup 18}F]DBT-10 metabolites was found in ex vivo brain tissue samples. Kinetic analysis of PET data was best described by the two-tissue compartment model. Estimated V{sub T}/f{sub P} values were 193-376 ml/cm{sup 3} across regions, with regional rank order of thalamus > frontal cortex > striatum

  19. Automated radiochemical processing for clinical PET

    International Nuclear Information System (INIS)

    Padgett, H.C.; Schmidt, D.G.; Bida, G.T.; Wieland, B.W.; Pekrul, E.; Kingsbury, W.G.

    1991-01-01

    With the recent emergence of positron emission tomography (PET) as a viable clinical tool, there is a need for a convenient, cost-effective source of the positron emitter-labeled radiotracers labeled with carbon-11, nitrogen-13, oxygen-15, and fluorine-18. These short-lived radioisotopes are accelerator produced and thus, require a cyclotron and radiochemistry processing instrumentation that can be operated 3 in a clinical environment by competant technicians. The basic goal is to ensure safety and reliability while setting new standards for economy and ease of operation. The Siemens Radioisotope Delivery System (RDS 112) is a fully automated system dedicated to the production and delivery of positron-emitter labeled precursors and radiochemicals required to support a clinical PET imaging program. Thus, the entire RDS can be thought of as an automated radiochemical processing apparatus

  20. Biodistribution and radiation dosimetry of {sup 68}Ga-PSMA HBED CC - a PSMA specific probe for PET imaging of prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Pfob, Christian H.; Ziegler, Sibylle; Graner, Frank Philipp; Koehner, Markus; Schachoff, Sylvia; Blechert, Birgit; Scheidhauer, Klemens; Schwaiger, Markus; Eiber, Matthias [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Wester, Hans-Juergen [Technische Universitaet Muenchen, Chair of Pharmaceutical Radiochemistry, Department Chemie, Garching (Germany); Maurer, Tobias [Technische Universitaet Muenchen, Department of Urology, Munich (Germany)

    2016-10-15

    Positron emission tomography (PET) agents targeting the prostate-specific membrane antigen (PSMA) are currently under broad clinical and scientific investigation. {sup 68}Ga-PSMA HBED-CC constitutes the first {sup 68}Ga-labelled PSMA-inhibitor and has evolved as a promising agent for imaging PSMA expression in vivo. The aim of this study was to evaluate the whole-body distribution and radiation dosimetry of this new probe. Five patients with a history or high suspicion of prostate cancer were injected intravenously with a mean of 139.8 ± 13.7 MBq of {sup 68}Ga-PSMA HBED-CC (range 120-158 MBq). Four static skull to mid-thigh scans using a whole-body fully integrated PET/MR-system were performed 10 min, 60 min, 130 min, and 175 min after the tracer injection. Time-dependent changes of the injected activity per organ were determined. Mean organ-absorbed doses and effective doses (ED) were calculated using OLINDA/EXM. Injection of a standard activity of 150 MBq {sup 68}Ga-PSMA HBED-CC resulted in a median effective dose of 2.37 mSv (Range 1.08E-02 - 2.46E-02 mSv/MBq). The urinary bladder wall (median absorbed dose 1.64E-01 mGv/MBq; range 8.76E-02 - 2.91E-01 mGv/MBq) was the critical organ, followed by the kidneys (median absorbed dose 1.21E-01 mGv/MBq; range 7.16E-02 - 1.75E-01), spleen (median absorbed dose 4.13E-02 mGv/MBq; range 1.57E-02 - 7.32E-02 mGv/MBq) and liver (median absorbed dose 2.07E-02 mGv/MBq; range 1.80E-02 - 2.57E-02 mGv/MBq). No drug-related pharmacological effects occurred. The use of {sup 68}Ga-PSMA HBED-CC results in a relatively low radiation exposure, delivering organ doses that are comparable to those of other {sup 68}Ga-labelled PSMA-inhibitors used for PET-imaging. Total effective dose is lower than for other PET-agents used for prostate cancer imaging (e.g. {sup 11}C- and {sup 18}F-Choline). (orig.)

  1. Radioisotopes in nuclear medicine

    International Nuclear Information System (INIS)

    Samuel, A.M.

    2002-01-01

    Full text: A number of advances in diverse fields of science and technology and the fruitful synchronization of many a new development to address the issues related to health care in terms of prognosis and diagnosis resulted in the availability of host of modern diagnostic tools in medicine. Nuclear medicine, a unique discipline in medicine is one such development, which during the last four decades has seen exponential growth. The unique contribution of this specialty is the ability to examine the dynamic state of every organ of the body with the help of radioactive tracers. This tracer application in nuclear medicine to monitor the biological molecules that participate in the dynamic state of body constituents has led to a whole new approach to biology and medicine. No other technique has the same level of sensitivity and specificity as obtained in radiotracer technique in the study of in-situ chemistry of body organs. As modem medicine becomes oriented towards molecules rather than organs, nuclear medicine will be in the forefront and will become an integral part of a curative process for regular and routine application. Advances in nuclear medicine will proceed along two principal lines: (i) the development of improved sensitive detectors of radiation, powerful and interpretable data processing, image analysis and display techniques, and (ii) the production of exotic and new but useful radiopharmaceuticals. All these aspects are dealt with in detail in this talk

  2. Radioisotopes and their applications in highway testings

    International Nuclear Information System (INIS)

    Saxena, S.C.

    1974-01-01

    Applications of radioisotopes in highway testing are described. Radioisotopic methods have been used to determine : (1) moisture and density of soil and base materials for compaction control, (2) magnesium oxide content of cement, (3) permeability of bituminous coverings and (4) field density of freshly laid hot bituminous concrete surface. Possible uses of nuclear explosives for production of aggregates and of radioisotopes for determination of deflection in the design of flexible pavements are indicated. (M.G.B.)

  3. Research trends in radioisotopes: a scientometric analysis

    International Nuclear Information System (INIS)

    Sagar, Anil; Kademani, B.S.; Bhanumurthy, K.; Ramamoorthy, N.

    2014-01-01

    Radioisotopes or radionuclides are radioactive forms of elements and are usually produced in research reactors and accelerators. They have wide ranging applications in healthcare, industry, food and agriculture, and environmental monitoring. Following over five decades of vast experience accumulated, radioisotope technology has developed to a high degree of sophistication and it is estimated that about 200 radioisotopes are in regular use. This paper attempts to highlight the publication status and growth of radioisotope research across the world and make quantitative and qualitative assessment by way of analyzing the following features of research output based on Web of Science database during the period 1993-2012. (author)

  4. Medical radioisotopes for the next century

    International Nuclear Information System (INIS)

    Carr, S.W.

    1999-01-01

    Radioisotopes are widely used in medicine (Nuclear Medicine) for diagnosis, palliation and therapy of heart disease, cancer, muscoskeletal and neurological conditions. The radioisotopes used are both reactor and cyclotron produced. The utilisation is currently growing and is expected to continue to grow over the next 10-20 years. The combination of radioisotope and delivery vehicle can be designed to meet the intended end use. This paper will deal with the main approaches to the use of radioisotopes for Nuclear medicine ad future prospects for the area

  5. Active Radiation Level Measurement on New Laboratory Instrument for Evaluating the Antibacterial Activity of Radioisotope

    International Nuclear Information System (INIS)

    Joh, Eunha; Park, Jang Guen

    2014-01-01

    A disc method has been widely used to measure the antibacterial effect of chemical agents. However, it is difficult to measure the antibacterial effect of radioisotopes using a disc method. A disc method is a method for diffusing a drug by placing the drug containing disc on the medium. In this method, radioisotopes are diffused on the medium and it is difficult to measure the exact effect by radiation. Thus, new laboratory equipment needs to evaluate the antibacterial activity by the radioisotopes. In this study, we measured the radiation level of radioisotopes on a new laboratory instrument using a MCNP. A disc method has been widely used to measure the antibacterial effect of chemical agents. This method uses a drug diffusion system for the measurement of anti-bacterial antibiotics. To measure the antimicrobial activity of a radioisotope, a new type of laboratory instrument is necessary to prevent the drug from spreading. The radioisotopes are used to diagnose and treat cancer. However, studies for anti-biotical use have not progressed. The radiation of radioisotopes has the effect of killing bacteria. Before this study proceeds further, it is necessary to be able to measure the antimicrobial activity of the radioisotope easily in the laboratory. However, in this study, it was possible to measure the antimicrobial activity of the radioisotope in the laboratory using a new laboratory instrument. We intend to start evaluation studies of the antibacterial activity of specific radioisotopes. In addition, it will be possible to develop research to overcome diseases caused by bacteria in the future

  6. Active Radiation Level Measurement on New Laboratory Instrument for Evaluating the Antibacterial Activity of Radioisotope

    Energy Technology Data Exchange (ETDEWEB)

    Joh, Eunha; Park, Jang Guen [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    A disc method has been widely used to measure the antibacterial effect of chemical agents. However, it is difficult to measure the antibacterial effect of radioisotopes using a disc method. A disc method is a method for diffusing a drug by placing the drug containing disc on the medium. In this method, radioisotopes are diffused on the medium and it is difficult to measure the exact effect by radiation. Thus, new laboratory equipment needs to evaluate the antibacterial activity by the radioisotopes. In this study, we measured the radiation level of radioisotopes on a new laboratory instrument using a MCNP. A disc method has been widely used to measure the antibacterial effect of chemical agents. This method uses a drug diffusion system for the measurement of anti-bacterial antibiotics. To measure the antimicrobial activity of a radioisotope, a new type of laboratory instrument is necessary to prevent the drug from spreading. The radioisotopes are used to diagnose and treat cancer. However, studies for anti-biotical use have not progressed. The radiation of radioisotopes has the effect of killing bacteria. Before this study proceeds further, it is necessary to be able to measure the antimicrobial activity of the radioisotope easily in the laboratory. However, in this study, it was possible to measure the antimicrobial activity of the radioisotope in the laboratory using a new laboratory instrument. We intend to start evaluation studies of the antibacterial activity of specific radioisotopes. In addition, it will be possible to develop research to overcome diseases caused by bacteria in the future.

  7. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1985

    Energy Technology Data Exchange (ETDEWEB)

    Baker, D.A.

    1986-08-01

    This document describes radioisotope distribution from DOE facilities to private firms including foreign and other DOE facilities. The information is divided into five sections: (1) isotope suppliers, facility contacts, and isotopes or services supplied; (2) customers, suppliers, and isotopes purchased; (3) isotopes purchased cross-referenced with customer numbers; (4) geographic locations of radioisotope customers; and (5) radioisotope sales and transfer - FY 1985.

  8. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1985

    International Nuclear Information System (INIS)

    Baker, D.A.

    1986-08-01

    This document describes radioisotope distribution from DOE facilities to private firms including foreign and other DOE facilities. The information is divided into five sections: (1) isotope suppliers, facility contacts, and isotopes or services supplied; (2) customers, suppliers, and isotopes purchased; (3) isotopes purchased cross-referenced with customer numbers; (4) geographic locations of radioisotope customers; and (5) radioisotope sales and transfer - FY 1985

  9. Radioisotope diagnostics of neoplasms in children

    International Nuclear Information System (INIS)

    Mechev, D.S.; Sinyuta, B.T.; Borisyuk, T.B.

    1982-01-01

    On the basis of radioisotope studies of 111 children with neoplasms of locomotor system, retroperitoneal space, maxillofacial region and neck, the limits and possibilities of the method of positive radiodiagnostics with short-life radionuclides sup(99M)Tc pertechnetate and 99 Tc pyrophosphate have been analyzed. It is pointed out that sensitivity of the investigation method with sup(99M)Tc pyrophosphate is higher (91.6%) than that of the method with 99 Tc pertechnetate (84.5%). Specificity of the investigation method with 99 Tc p.ertechnetate is higher (71.5%) than that of the method with sup(99M)Tc pyrophosphate (30%). The method of positive radiodiagnostics is characterized by safety, atraumatism, low radiation burdens and possibility of its realization in ambulatory conditions

  10. Survey of industrial radioisotope savings

    International Nuclear Information System (INIS)

    1965-01-01

    Only three decades after the discovery of artificial radioactivity and two after radioisotopes became available in quantity, methods employing these as sources or tracers have found widespread use, not only in scientific research, but also in industrial process and product control. The sums spent by industry on these new techniques amount to millions of dollars a year. Realizing the overall attitude of industry to scientific progress - to accept only methods that pay relatively quickly - one can assume that the economic benefits must be of a still larger order of magnitude. In order to determine the extent to which radioisotopes are in daily use and to evaluate the economic benefits derived from such use, IAEA decided to make an 'International Survey on the Use of Radioisotopes in Industry'. In 1962, the Agency invited a number of its highly industrialized Member States to participate in this Survey. Similar surveys had been performed in various countries in the 1950's. However, the approaches and also the definition of the economic benefits differed greatly from one survey to another. Hence, the Agency's approach was to try to persuade all countries to conduct surveys at the same time, concerning the same categories of industries and using the same terms of costs, savings, etc. In total, 24 Member States of the Agency agreed to participate in the survey and in due course they submitted contributions. The national reports were discussed at a 'Study Group Meeting on Radioisotope Economics', convened in Vienna in March 1964. Based upon these discussions, the national reports have been edited and summarized. A publication showing the administration of the Survey and providing all details is now published by the Agency. From the publication it is evident that in general the return of technical information was quite high, of the order of 90%, but, unfortunately the economic response was much lower. However, most of the reports had some bearing on the economic aspects

  11. The industrial application of radioisotopes

    International Nuclear Information System (INIS)

    Frevert, E.

    1991-01-01

    In this paper the two main fields of the industrial application of radioisotopes are introduced. In the field of process controlling device and control first about the transmission and the backscattering methods is reported. Then the x-ray fluorescence method and the moisture gauging with neutrons are mentioned. Also the measuring of depth of charge. In the field of tracer investigations about all kinds of flow and intermixture measurements is reported. And investigations of corrosion, wear and lubrication and precise location of nonmetallic pipe lines are mentioned. (Author)

  12. Radioisotope studies on coconut nutrition

    International Nuclear Information System (INIS)

    Ray, P.K.

    1979-01-01

    Studies on coconut nutrition using radioisotopes are reviewed. Methods of soil placement and plant injection techniques for feeding nutrients to coconut have been studied, and irrigation practices for efficient uptake and utilization of nutrients are suggested. The absorption, distribution and translocation pattern of radioactive phosphorus and its incorporation into the nucleic acid fraction in healthy and root (wilt) diseased coconut palms have been studied. Carbon assimilation rates (using carbon-14) in spherical, semispherical and erect canopied coconut palms having different yield characteristics are reviewed and discussed. (author)

  13. Artificial radioisotopes in hydrological investigation

    International Nuclear Information System (INIS)

    Plata-Bedmar, A.

    1988-01-01

    Radioisotope techniques have an important part in hydrological investigations. Sealed radiation sources have been used for measurements of sediments transported by river water, of thickness and density of sediment layers. X-ray fluorescence analysis and well-logging are widely applied in hydrological research. Tracer techniques have been useful in flow rate and river dynamics research, sediments tracing, irrigation and ground water problems, infiltration rate evaluation etc. The IAEA is supporting several projects involving the use of radioactive tracers in hydrological investigations p.e. in Guatemala, Romania, South East Asia, Brazil, Chile and Nicaragua

  14. Preparation of an annual report for a consolidated radioisotope licence

    International Nuclear Information System (INIS)

    1985-01-01

    A consolidated radioisotope licence is a single license issued by the Atomic Energy Control Board (AECB) to an institution having many users of radioactive materials. The licence is issued when the institution has fulfilled the requirements set by the AECB and has implemented policies and procedures which will ensure the maintenance of an effective radiation safety program. The consolidated licence is retained only if the results of AECB inspections are satisfactory -- or remedial action is taken promptly -- and if the institution reports regularly about the status of its radiation safety program. One aspect of this reporting procedure is an annual report. This guide describes the information that the AECB requires in the annual report. The guide applies primarily to universities and research institutions where a wide variety of radioisotope uses take place. The guide does not affect most other institutions or facilities, either because the nature and extent of their operations with radioactive materials do not lend themselves to consolidated licensing or because they are not licensed by the Radioisotopes and Transportation Division. (For example, this guide does not apply to reactors, to accelerators, or to waste management or uranium mining or refining facilities.) The information in the annual report should be specific to the consolidated radioisotope licence. Incidents, staff exposures, and waste associated with accelerators, research reactors, and waste management facilities should be excluded from this report unless they affected activities under the consolidated licence

  15. Project of a PET center at IEN-Rio de Janeiro

    International Nuclear Information System (INIS)

    Santos, G.R.; Suita, J.C.

    2001-01-01

    Full text: The Institute of Nuclear Engineering plans to establish a cyclotron-PET facility for production of positron emitting radionuclide for nuclear medicine. Indeed, this facility is part of a bigger project: the first PET Center in Brazil. It is envisioned that this Center would play a central role in the introduction to the region modern technologies in nuclear medicine based on PET radiopharmaceuticals. The problem to be addressed is to gather sufficient conditions to setting up the PET Center. Specifically, the IAEA's assistance would be indispensable to financing the proper equipment's for positron emitter radioisotopes' production, synthesis, labeling, and quality control. The IAEA's assistance would be also valuable in personnel training, as well as researcher's interchange and technical cooperation. With the IAEA's assistance, the PET Center project, already started, would gain a considerable impulse to its conclusion. The IAEA would be of greatly contributing to the improvement of the Brazilians' health care. This contribution takes account that the lEN's PET Center would be offering last generation exams and diagnosis, based on nuclear techniques. Therefore, the IEN is requesting the co-operation of the IAEA to set-up such a facility. The way of that requesting is strictly ordinary, and follows the logical framework structure for project elaboration. The first version of that project is now presented in its original form. From that is possible to extract a resumed table with the fundamental of logical framework, as well as consistence verification by a characteristic check list. Obviously some improvements must be done, and it will be performed before deadline. This way, by the end of 2004, the IEN hopes to be contributing in many application areas, and with Brazilian's health care system, by making available last generation techniques of diagnosis, becoming a center of reference in Latin America. (author)

  16. Radioisotope electric propulsion of sciencecraft to the outer solar system and near-interstellar space

    International Nuclear Information System (INIS)

    Noble, R.J.

    1998-08-01

    Recent results are presented in the study of radioisotope electric propulsion as a near-term technology for sending small robotic sciencecraft to the outer Solar System and near-interstellar space. Radioisotope electric propulsion (REP) systems are low-thrust, ion propulsion units based on radioisotope electric generators and ion thrusters. Powerplant specific masses are expected to be in the range of 100 to 200 kg/kW of thrust power. Planetary rendezvous missions to Pluto, fast missions to the heliopause (100 AU) with the capability to decelerate an orbiter for an extended science program and prestellar missions to the first gravitational lens focus of the Sun (550 AU) are investigated

  17. PET imaging of adoptive progenitor cell therapies

    International Nuclear Information System (INIS)

    Gelovani, Juri G.

    2008-01-01

    is proposed to circumvent the major limitation of in vitro radiolabeling - the eventual radiolabel decay. Stable transduction of stem cells in vitro would allow for the selection of high quality stem cells with optimal functional parameters of the transduced reporter systems. The use of a long-lived radioisotope 124I to label a highly specific reporter gene probe will allow for ex vivo labeling of stem cells and their imaging immediately after injection and during the following next week. The use of short-lived radioisotopes (i.e., 18F) to label highly specific reporter gene probes will allow repetitive PET imaging for the assessment of to stem cell migration, targeting, differentiation, and long-term viability of stem cell-derived tissues. Qualifications of the research team and resources. An established research team of experts in various disciplines has been assembled at MD Anderson Cancer Center (MDACC) over the past two years including the PI, senior co-investigators and collaborators. The participants of this team are recognized internationally to be among the leaders in their corresponding fields of research and clinical medicine. The resources at MDACC are exceptionally well developed and have been recently reinforced by the installation of a microPET and microSPECT/CT cameras, and a 7T MRI system for high resolution animal imaging; and by integrating a synthetic chemistry core for the development and production of precursors for radiolabeling.

  18. PET imaging of adoptive progenitor cell therapies.

    Energy Technology Data Exchange (ETDEWEB)

    Gelovani, Juri G.

    2008-05-13

    stem cell imaging is proposed to circumvent the major limitation of in vitro radiolabeling – the eventual radiolabel decay. Stable transduction of stem cells in vitro would allow for the selection of high quality stem cells with optimal functional parameters of the transduced reporter systems. The use of a long-lived radioisotope 124I to label a highly specific reporter gene probe will allow for ex vivo labeling of stem cells and their imaging immediately after injection and during the following next week. The use of short-lived radioisotopes (i.e., 18F) to label highly specific reporter gene probes will allow repetitive PET imaging for the assessment of to stem cell migration, targeting, differentiation, and long-term viability of stem cell-derived tissues. Qualifications of the research team and resources. An established research team of experts in various disciplines has been assembled at MD Anderson Cancer Center (MDACC) over the past two years including the PI, senior co-investigators and collaborators. The participants of this team are recognized internationally to be among the leaders in their corresponding fields of research and clinical medicine. The resources at MDACC are exceptionally well developed and have been recently reinforced by the installation of a microPET and microSPECT/CT cameras, and a 7T MRI system for high resolution animal imaging; and by integrating a synthetic chemistry core for the development and production of precursors for radiolabeling.

  19. Development of Radioisotope Tracer Technology

    International Nuclear Information System (INIS)

    Jung, Sung Hee; Jin, Joon Ha; Kim, Jong Bum; Kim, Jin Seop; Kim, Jae Jo; Park, Soon Chul; Lim, Don Soon; Choi, Byung Jong; Jang, Dong Soon; Kim, Hye Sook

    2007-06-01

    The project is aimed to develop the radiotracer technology for process optimization and trouble-shooting to establish the environmental and industrial application of radiation and radioisotopes. The advanced equipment and software such as high speed data acquisition system, RTD model and high pressure injection tool have developed. Based on the various field application to the refinery/petrochemical industries, the developed technology was transfer to NDT company for commercial service. For the environmental application of radiotracer technology, injector, detector sled, core sampler, RI and GPS data logging system are developed and field tests were implemented successfully at Wolsung and Haeundae beach. Additionally tracer technology were also used for the performance test of the clarifier in a wastewater treatment plant and for the leak detection in reservoirs. From the experience of case studies on radiotracer experiment in waste water treatment facilities, 'The New Excellent Technology' is granted from the ministry of environment. For future technology, preliminary research for industrial gamma transmission and emission tomography which are new technology combined with radioisotope and image reconstruction are carried out

  20. Decontamination of radioisotope production facility

    International Nuclear Information System (INIS)

    Daryoko, M.; Yatim, S.; Suseno, H.; Wiratmo, M.

    1998-01-01

    The strippable coating method use phosphoric glycerol and irradiated latex as supporting agents have been investigated. The investigation used some decontaminating agents: EDTA, citric acid, oxalic acid and potassium permanganate were combined with phosphoric glycerol supporting agent, then EDTA Na 2 , sodium citric, sodium oxalic and potassium permanganate were combined with irradiated latex supporting agent. The study was needed to obtain the representative operating data, will be implemented to decontamination the Hot Cell for radioisotope production. The experiment used 50x50x1 mm stainless steel samples and contaminated by Cs-137 about 1.1x10 -3 μCi/cm 2 . This samples according to inner cover of Hot Cell material, and Hot Cell activities. The decontamination factor results of the investigation were: phosphoric glycerol as supporting agent, about 20 (EDTA as decontaminating agent) to 47 (oxalic acid as decontaminating agent), and irradiated latex as supporting agent, about 11.5 (without decontamination agent) to 27 (KMnO 4 as decontaminating agent). All composition of the investigation have been obtained the good results, and can be implemented for decontamination of Hot Cell for radioisotope production. The irradiated latex could be recommended as supporting agent without decontaminating agent, because it is very easy to operate and very cheap cost. (author)

  1. PET/CT and radiotherapy

    International Nuclear Information System (INIS)

    Messa, C.; CNR, Milano; S. Gerardo Hospital, Monza; Di Muzio, N.; Picchio, M.; Bettinardi, V.; Gilardi, M.C.; CNR, Milano; San Raffaele Scientific Institute, Milano; Fazio, F.; CNR, Milano; San Raffaele Scientific Institute, Milano; San Raffaele Scientific Institute, Milano

    2006-01-01

    This article reviews the state of the art of PET/CT applications in radiotherapy, specifically its use in disease staging, patient selection, treatment planning and treatment evaluation. Diseases for which radiotherapy with radical intent is indicated will be considered, as well as those in which PET/CT may actually change the course of disease. The methodological and technological aspects of PET/CT in radiotherapy are discussed, focusing on the problem of target volume definition with CT and PET functional imaging and the problem of tumor motion with respect to imaging and dose delivery

  2. Aspects of radioisotopes utilization in clinical medicine

    International Nuclear Information System (INIS)

    Rocha, A.F.G.; Lima e Forti, C.A. de; Cunha, M. da C.; Souza Maciel, O. de

    1973-01-01

    A revision concerning radioisotope use in Medicine have been dow. Harmless and effeciency of radioisotopes are shown. Techniques and advantages of tracers used for brain scintiscanning, lung scintiscanning, liver scintinscanning, spleen scintiscanning, bone scintiscanning and thyroid scintiscanning are described and images of them are presented [pt

  3. Trends in the development of radioisotope batteries

    International Nuclear Information System (INIS)

    Goeldner, R.; Leonhardt, J.W.; Radmaneche, R.; Schlegel, H.

    1978-01-01

    Improved methods for producing radioisotopes by nuclear fuel reprocessing and the rapid development of microelectronics offer new possibilities for utilizing radioisotope batteries. A review is given of the main principles of conversion of decay energy into electric power. The current state of such energy sources is evaluated. Finally, new fields of application and further trends in the development are indicated. (author)

  4. Elementary concepts of the radioisotopes uses

    International Nuclear Information System (INIS)

    Pisarev, Mario A.

    2004-01-01

    Endocrinology has been one of the specialties earlier benefited for the radioisotopes uses in the diagnosis and treatment of different affections. These applications are based on the radioisotopes property of biochemical behaving as non- radioactive molecules, and at the same time, radiations emitting that can be detected by suitable means (diagnostic utility) or that have effects on biological systems (therapeutic action). (author) [es

  5. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1986

    International Nuclear Information System (INIS)

    Lamar, D.A.

    1988-01-01

    Data were collected and compiled on radioisotopes produced and sold by Department of Energy (DOE) facilities, and on services rendered by DOE facilities. Compiled data were published and distributed in the document list of DOE Radioisotope Customers with Summary of Radioisotope Shipments, FY 1986, PNL-6361, October 1987. The DOE facilities that supplied information for the compilation were Argonne National Laboratory, Brookhaven National Laboratory, Hanford Engineering Development Laboratory, Idaho National Engineering Laboratory, Los Alamos National Laboratory, Oak Ridge National Laboratory, Pacific Northwest Laboratory, Savannah River Plant, and UNC Nuclear Industries, Inc. (Hanford). The data provided were reported in several different ways: (1) a list of radioisotopes and services provided by each facility; (2) a list of radioisotope customers, the supplying DOE facility, and the radioisotope or service provided to each customer; and (3) a list of the quantity and value of each radioisotope or service sold by each DOE facility. The sales information covered foreign customers, domestic private customers, and domestic DOE customers

  6. Role of radioisotopes in the study of insect pests

    International Nuclear Information System (INIS)

    Mansour, M.

    2013-01-01

    Although the use of nuclear techniques, particularly radioisotopes, in entomological research is less than a century old, the contribution of radioisotopes to the science of studying insects (Entomology) is indispensable. In fact, radioisotopes provided a very important and sometimes a unique tool for solving many research problems in entomology. This article discusses the most important and widely used applications of radioisotopes in studying insect pests. In particular, it concentrates on the subject of radioisotopes used in entomological research, methods of labeling insect with radioisotopes, half life of radioisotopes, and the role of radioisotopes in physiological, ecological, biological and behavioral studies of insects. (author)

  7. Design of radioisotope power systems facility

    International Nuclear Information System (INIS)

    Eschenbaum, R.C.; Wiemers, M.J.

    1991-01-01

    Radioisotope power systems currently produced for the U.S. Department of Energy Office of Special Applications by the Mound Laboratory at Miamisburg, Ohio, have been used in a variety of configurations by the Department of Defense and the National Aeronautics and Space Administration. A forecast of fugure radioisotope power systems requirements showed a need for an increased production rate beyond the capability of the existing Mound Laboratory. Westinghouse Hanford Company is modifying the Fuels and Materials Examination Facility on the Hanford Site near Richland, Washington, to install the new Radioisotope Power Systems Facility for assembling future radioisotope power systems. The facility is currently being prepared to assemble the radioisotope thermoelectric generators required by the National Aeronautics and Space Administration missions for Comet Rendezvous Asteroid Flyby in 1995 and Cassini, an investigation of Saturn and its moons, in 1996

  8. Activity calculation of radioisotopes in HFETR

    International Nuclear Information System (INIS)

    Liu Shuiqing

    1996-12-01

    The activity calculating method and formulas of seven kinds of radioisotopes for High Flux Engineering Test REactor (HFETR) are given. The perturbation of targets to neutron fluence rate is considered while targets are put into the neutron fluence rate field of reactor core. All perturbing factors of seven kinds of radioisotopes being used in HFETR are presented. After considering the perturbation, the calculating accuracy of radioisotope activity has been raised 10%. The given method and formulas have ended the history of all activities estimated by experiences, except for that of 60 Co, in the radioisotope production of HFETR. The conclusions are also useful and instructive for the production of radioisotopes in HFETR. (8 tabs.)

  9. Regulations concerning the radionuclides uses in France; Reglementation de l'utilisation des radioisotopes en France

    Energy Technology Data Exchange (ETDEWEB)

    Vergne, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Bugnard, L [Institut national d' Hygiene (France)

    1955-07-01

    The progress in the uses of radioisotopes has been conditioned by increasing the number of trained workers and researchers and developing theoretical teaching in universities since 1950 in France as well as developing a national control of the distribution and uses of radioisotopes. With the large diffusion and development of radioisotopes uses and applications, new rules and regulations came to control the importation, exportation, transport and utilization of radioisotopes. In the first part, it described the different French laws since 1934 and their successive modifications which ruled on the production, manipulation and utilization of radioisotopes. An inter-ministerial committee was created in 1952 to advise and inform of all the questions related to the preparation, importation, exportation, possession and distribution of radioisotopes. The transport regulations are in constant evolution and has got to meet with international recommendations. It distinguished three different type of transport: road, river and railway transport, postal transport and finally air transport. All the different transports have their specific packaging, maximum transportable quantity, maximum material intensity and labelling requirements. The regulations about customs duties are specified as well as the administrative formalities for non natural radioisotopes importation. Since 1950, diseases caused by irradiation to natural or artificial radioactive materials are recognised as professional diseases and a table of the actual regulations is presented. (M.P.)

  10. Application of radioisotopes in pharmaceutical research

    International Nuclear Information System (INIS)

    Khujaev, S.

    2004-01-01

    Full text: To use of radioisotopes in the processes of receiving radiopharmaceutical diagnostic means it is widely know [1]. Radioactivity labeled chemical compounds, pharmacological kinetics of which allows one solving a concrete diagnostic problem in an organism are used in radio pharmaceutics. In spite of this choice of the radioisotope, possessing the most favorable nuclei-physical characteristics for it to be detected and minimization of beam loadings, be of great importance. Development of a method of introduction of a radioisotope also has important value, as it is included into chemical structure of a radiopharmaceutical preparation. One more way of use of radioisotopes in pharmaceutics is their use as a radioactive mark at a stage of creation of a new medical product. And in this case, all those moments, which are listed above, take place. Preparations labeling by radioisotopes are used basically for their studying pharmacological kinetics. In Institute of nuclear physics AS RU, in recent years, works are done on studying pharmacological kinetics of some new medical products, which have been synthesized in the Tashkent pharmaceutical institute. These preparations are on the basis of microelements with a complex set of properties possessing expressed biological activity and have great value in pharmaceutical science of Republic of Uzbekistan. Reception of labeled compounds of all preparations was carried out by a method of introduction of a radioisotope at a stage of their synthesis. The work presents the results of researches on synthesis and study of pharmacological kinetics of radioactively labeled preparations - PIRACIN, labeled by radioisotope 69m Zn; FERAMED, labeled by radioisotope 59 Fe; COBAVIT, labeled by radioisotope 57 Co; VUC, labeled by radioisotope 57 Co

  11. PET and endocrine tumors

    International Nuclear Information System (INIS)

    Rigo, P.; Belhocine, T.; Hustinx, R.; Foidart-Willems, J.

    2000-01-01

    The authors review the main indications of PET examination, and specifically of 18 FDG, in the assessment of endocrine tumors: of the thyroid, of the parathyroid, of the adrenal and of the pituitary glands. Neuroendocrine tumors, gastro-entero-pancreatic or carcinoid tumors are also under the scope. Usually, the most differentiated tumors show only poor uptake of the FDG as they have a weak metabolic and proliferative activity. In the assessment of endocrine tumors, FDG-PET should be used only after most specific nuclear examinations been performed. (author)

  12. Radioisotopic studies in renal transplantation

    International Nuclear Information System (INIS)

    Levasseur, A.; Robillard, R.; Lemieux, R.; Dandavino, R.; Girard, R.

    1981-01-01

    Radioisotopic evaluation of kidney graft function has greatly reduced the need for more invasive studies such as arteriography, retrograde pyelograpy and graft biopsy. The schedule of sequential studies beginning the day after transplant may be modified according to the patient's clinical or biochemical status. The combined use of I 131 Hippuran and sup(99m)Tc DTPA allows early detection of graft rejection and its differentiation from tubular necrosis. Scintigraphic images may have a characteristic appearance in cases of arterial, venous or urinary obstruction, urinary fistule, infarction, abcess and lymphocele. This non-invasive diagnostic study requiring only an intravenous injection is simple, rapid, accurate and may be repeated as often as necessary. (auth) [fr

  13. Radioisotope studies under pathologic conditions

    International Nuclear Information System (INIS)

    DeRossi; Salvatori, M.; Valenza, V.

    1987-01-01

    This article presents a general discussion on salivary pathology, before dealing with the various salivary gland diseases which can draw real advantage from radioisotope studies. Clinical problems related to the salivary glands first concern diffuse or focal glandular swelling. Focal swelling includes inflammatory or metastatic deposits in preauricular or submandibular lymph nodes, cysts, abscesses, foci of inflammation, benign and malignant neoplasms of the salivary glands themselves or of surrounding blood or lymph vessels, nerves, connective tissue, and oral mucosa. Primary tumors of the salivary glands are rare and usually benign. The combination of a systemic disease with dry mouth and dry eyes due to inflamed conjunctiva and cornea because of decreased fluid production, forms Sjogren syndrome. It may also cause diffuse glandular swelling. Chronic alcoholism, cirrhosis, diabetes mellitus, hyperlipoproteinemia, and malnutrition are other pathologic conditions sometimes associated with diffuse salivary gland swelling

  14. Linear accelerator for radioisotope production

    International Nuclear Information System (INIS)

    Hansborough, L.D.; Hamm, R.W.; Stovall, J.E.

    1982-02-01

    A 200- to 500-μA source of 70- to 90-MeV protons would be a valuable asset to the nuclear medicine program. A linear accelerator (linac) can achieve this performance, and it can be extended to even higher energies and currents. Variable energy and current options are available. A 70-MeV linac is described, based on recent innovations in linear accelerator technology; it would be 27.3 m long and cost approx. $6 million. By operating the radio-frequency (rf) power system at a level necessary to produce a 500-μA beam current, the cost of power deposited in the radioisotope-production target is comparable with existing cyclotrons. If the rf-power system is operated at full power, the same accelerator is capable of producing an 1140-μA beam, and the cost per beam watt on the target is less than half that of comparable cyclotrons

  15. Radioisotope tracer applications in industry

    International Nuclear Information System (INIS)

    Rao, S.M.

    1987-01-01

    Radioisotope tracers have many advantages in industrial trouble-shooting and studies on process kinetics. The applications are mainly of two types: one leading to qualitative (Yes or No type) information and the other to quantitative characterisation of flow processes through mass balance considerations and flow models. ''Yes or No'' type methods are mainly used for leakage and blockage locations in pipelines and in other industrial systems and also for location of water seepage zones in oil wells. Flow measurements in pipelines and mercury inventory in electrolytic cells are good examples of tracer methods using the mass balance approach. Axial dispersion model and Tanks-in-Series model are the two basic flow models commonly used with tracer methods for the characterisation of kinetic processes. Examples include studies on flow processes in sugar crystallisers as well as in a precalcinator in a cement plant. (author). 18 figs

  16. Radioisotopic Studies of Brain Uptake

    International Nuclear Information System (INIS)

    Oldendorf, W. H.

    1970-01-01

    Measurements of the uptake of radioactive substances in the brain tissues after their administration by injection or inhalation provide an a traumatic approach to the study of blood flow and metabolic processes in the brain. This paper reviews the anatomical,physiological and physical problems arising in the measurement of radioactivity in the brain. The factors governing the passage of various classes of substances through the brain capillaries and their transport through the brain tissues are first considered. The physical problems arising in the measurement of radioactivity in the brain are then discussed. The main difficulties in such measurements is shown to arise from the contribution to the observed counting rate from radioactivity in the scalp and skull. This contribution can be minimized by the use of special collimators designed to view only a part of the brain but to include in their field of view a minimum of non-neural tissue. A further possibility arises with radioisotopes such as 113 In m which emit characteristic X radiation as well as y radiation since the contribution of the former to the total observed counting rate is almost entirely due to radioactivity in the superficial tissues whereas that of the latter is due to radioactivity in the superficial tissues and the brain. By recording the counting rates in appropriate channels of the photon spectrum it is thus possible to correct the results for radioactivity in the scalp and skull. With radioisotopes such as 75 Sc which emit two or more photons in cascade, coincidence counting techniques offer still a further possibility to minimize the contribution from radioactivity in the superficial tissues. Various potential applications of these techniques are described. (author)

  17. US Department of Energy radioisotope customers with summary of radioisotope shipments, FY 1988

    International Nuclear Information System (INIS)

    Van Houten, N.C.

    1989-06-01

    Pacific Northwest Laboratory (PNL) prepared this edition of the radioisotope customer list at the request of the Office of Health and Environmental Research (ER-73), Office of Energy Research, US Department of Energy (DOE). This is the 25th report in a series dating from 1964. This report covers DOE radioisotope sales and distribution activities by its facilities to domestic, foreign and other DOE facilities for FY 1988. The report is divided into five sections: radioisotope suppliers, facility contacts, and radioisotopes or services supplied; a list of customers, suppliers, and radioisotopes purchased; a list of radioisotopes purchased cross-referenced to customer numbers; geographic locations of radioisotope customers; and radioisotope sales and transfers -- FY 1988. Radioisotopes not previously reported in this series of reports were argon-37, arsenic-72, arsenic-73, bismuth-207, gadolinium-151, rhenium-188, rhodium-101, selenium-72, xenon-123 and zirconium-88. The total value of DOE radioisotope sales for FY 1988 was $11.1 million, an increase of 3% from FY 1987

  18. US Department of Energy radioisotope customers with summary of radioisotope shipments, FY 1988

    Energy Technology Data Exchange (ETDEWEB)

    Van Houten, N.C.

    1989-06-01

    Pacific Northwest Laboratory (PNL) prepared this edition of the radioisotope customer list at the request of the Office of Health and Environmental Research (ER-73), Office of Energy Research, US Department of Energy (DOE). This is the 25th report in a series dating from 1964. This report covers DOE radioisotope sales and distribution activities by its facilities to domestic, foreign and other DOE facilities for FY 1988. The report is divided into five sections: radioisotope suppliers, facility contacts, and radioisotopes or services supplied; a list of customers, suppliers, and radioisotopes purchased; a list of radioisotopes purchased cross-referenced to customer numbers; geographic locations of radioisotope customers; and radioisotope sales and transfers -- FY 1988. Radioisotopes not previously reported in this series of reports were argon-37, arsenic-72, arsenic-73, bismuth-207, gadolinium-151, rhenium-188, rhodium-101, selenium-72, xenon-123 and zirconium-88. The total value of DOE radioisotope sales for FY 1988 was $11.1 million, an increase of 3% from FY 1987.

  19. Preclinical evaluation of BAY 1075553, a novel 18F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancer

    International Nuclear Information System (INIS)

    Lesche, Ralf; Kettschau, Georg; Gromov, Alexey V.; Boehnke, Niels; Borkowski, Sandra; Moenning, Ursula; Doehr, Olaf; Graham, Keith; Hegele-Hartung, Christa; Dinkelborg, Ludger M.

    2014-01-01

    Prostate-specific membrane antigen (PSMA) is a transmembrane protein overexpressed in prostate cancer and is therefore being explored as a biomarker for diagnosing and staging of the disease. Here we report preclinical data on BAY 1075553 (a 9:1 mixture of (2S,4S)- and (2R,4S)-2-[ 18 F]fluoro-4-phosphonomethyl-pentanedioic acid), a novel 18 F-labelled small molecule inhibitor of PSMA enzymatic activity, which can be efficiently synthesized from a direct radiolabelling precursor. The 18 F-radiolabelled stereoisomers of 2-[ 18 F]fluoro-4-(phosphonomethyl)-pentanedioic acid were synthesized from their respective isomerically pure precursors dimethyl 2-{[bis(benzyloxy)phosphoryl ]methyl}-4-(tosyloxy)pentanedioate. In vivo positron emission tomography (PET) imaging and biodistribution studies were conducted in mice bearing LNCaP, 22Rv1 and PC-3 tumours. Pharmacokinetic parameters and dosimetry estimates were calculated based on biodistribution studies in rodents. For non-clinical safety assessment (safety pharmacology, toxicology) to support a single-dose human microdose study, off-target effects in vitro, effects on vital organ functions (cardiovascular in dogs, nervous system in rats), mutagenicity screens and an extended single-dose study in rats were conducted with the non-radioactive racemic analogue of BAY 1075553. BAY 1075553 showed high tumour accumulation specific to PSMA-positive tumour-bearing mice and was superior to other stereoisomers tested. Fast clearance of BAY 1075553 resulted overall in low background signals in other organs except for high uptake into kidney and bladder which was mainly caused by renal elimination of BAY 1075553. A modest uptake into bone was observed which decreased over time indicating organ-specific uptake as opposed to defluorination of BAY 1075553 in vivo. Biodistribution studies found highest organ doses for kidneys and the urinary bladder wall resulting in a projected effective dose (ED) in humans of 0.0219 mSv/MBq. Non

  20. Preclinical evaluation of BAY 1075553, a novel {sup 18}F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lesche, Ralf; Kettschau, Georg; Gromov, Alexey V.; Boehnke, Niels; Borkowski, Sandra; Moenning, Ursula; Doehr, Olaf; Graham, Keith [Global Drug Discovery, Bayer Healthcare, Berlin, Germany, Berlin (Germany); Hegele-Hartung, Christa [Global Drug Discovery, Bayer Healthcare, Wuppertal, Germany, Wuppertal (Germany); Dinkelborg, Ludger M. [Global Drug Discovery, Bayer Healthcare, Berlin, Germany, Berlin (Germany); Piramal Imaging GmbH, Berlin (Germany)

    2014-01-15

    Prostate-specific membrane antigen (PSMA) is a transmembrane protein overexpressed in prostate cancer and is therefore being explored as a biomarker for diagnosing and staging of the disease. Here we report preclinical data on BAY 1075553 (a 9:1 mixture of (2S,4S)- and (2R,4S)-2-[{sup 18}F]fluoro-4-phosphonomethyl-pentanedioic acid), a novel {sup 18}F-labelled small molecule inhibitor of PSMA enzymatic activity, which can be efficiently synthesized from a direct radiolabelling precursor. The {sup 18}F-radiolabelled stereoisomers of 2-[{sup 18}F]fluoro-4-(phosphonomethyl)-pentanedioic acid were synthesized from their respective isomerically pure precursors dimethyl 2-{[bis(benzyloxy)phosphoryl ]methyl}-4-(tosyloxy)pentanedioate. In vivo positron emission tomography (PET) imaging and biodistribution studies were conducted in mice bearing LNCaP, 22Rv1 and PC-3 tumours. Pharmacokinetic parameters and dosimetry estimates were calculated based on biodistribution studies in rodents. For non-clinical safety assessment (safety pharmacology, toxicology) to support a single-dose human microdose study, off-target effects in vitro, effects on vital organ functions (cardiovascular in dogs, nervous system in rats), mutagenicity screens and an extended single-dose study in rats were conducted with the non-radioactive racemic analogue of BAY 1075553. BAY 1075553 showed high tumour accumulation specific to PSMA-positive tumour-bearing mice and was superior to other stereoisomers tested. Fast clearance of BAY 1075553 resulted overall in low background signals in other organs except for high uptake into kidney and bladder which was mainly caused by renal elimination of BAY 1075553. A modest uptake into bone was observed which decreased over time indicating organ-specific uptake as opposed to defluorination of BAY 1075553 in vivo. Biodistribution studies found highest organ doses for kidneys and the urinary bladder wall resulting in a projected effective dose (ED) in humans of 0.0219 m

  1. Development of a PET Prostate-Specific Membrane Antigen Imaging Agent: Preclinical Translation for Future Clinical Application

    Science.gov (United States)

    2017-10-01

    are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by...phase 0) application to the FDA by the end of the funding period. The small molecule imaging agents under study home to prostate specific membrane...funding period. The small molecule imaging agents under study home to prostate specific membrane antigen (PSMA) that is prevalent on a majority of

  2. The production and application of radioisotopes

    International Nuclear Information System (INIS)

    O'Neill, W.P.; Evans, D.J.R.

    1987-01-01

    This paper outlines the historical evolution of radioisotopes from first concepts and discoveries to significant milestones in their production and the development of applications throughout the world. Regarding production, it addresses the methods that have been used at various stages during this evolution outlining the important findings that have led to further developments. With respect to radioisotope applications, the paper addresses the development of markets in industry, medicine, and agriculture and comments on the size of these markets and their rate of growth. Throughout, the paper highlights the Canadian experience and it also presents a Canadian view of emerging prospects and a forecast of how the future for radioisotopes might develop. (author)

  3. Twenty years of Korea radioisotope association history

    International Nuclear Information System (INIS)

    2005-09-01

    This contents has two parts. The first part describes the present and post of Korea radioisotope association which are about the foundation of the association, organization, main projects and vision of the association. The second part is about the use and the prospect of radiation and radioisotope in Korea, which shows the plan of expansion of use of radiation and radioisotope, the prospect and present condition in fields such as medical, industry and farming, product and distribution, research and development of human resources, system and management of safety of radiation.

  4. Recommendations for the use of PET and PET-CT for radiotherapy planning in research projects.

    Science.gov (United States)

    Somer, E J; Pike, L C; Marsden, P K

    2012-08-01

    With the increasing use of positron emission tomography (PET) for disease staging, follow-up and therapy monitoring in a number of oncological indications there is growing interest in the use of PET and PET-CT for radiation treatment planning. In order to create a strong clinical evidence base for this, it is important to ensure that research data are clinically relevant and of a high quality. Therefore the National Cancer Research Institute PET Research Network make these recommendations to assist investigators in the development of radiotherapy clinical trials involving the use of PET and PET-CT. These recommendations provide an overview of the current literature in this rapidly evolving field, including standards for PET in clinical trials, disease staging, volume delineation, intensity modulated radiotherapy and PET-augmented planning techniques, and are targeted at a general audience. We conclude with specific recommendations for the use of PET in radiotherapy planning in research projects.

  5. Abstracts of the third conference on radioisotopes and their applications

    International Nuclear Information System (INIS)

    2002-10-01

    The Third Uzbekistan Conference on radioisotopes and their applications was held on 8-10 October, 2002 in Tashkent, Uzbekistan. The specialists discussed various aspects of modern problems of radiochemistry, radioisotope production, technology of radioisotopes and compounds, activations analysis applications, radionuclides, radioimmunoassays, application of radioisotopes in industry, medicine, biology and agriculture. More than 80 talks were presented in the meeting

  6. Abstracts of the second conference on radioisotopes and their applications

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    The Second Uzbekistan Conference on radioisotopes and their applications was held on 3-5 October, 2000 in Tashkent, Uzbekistan. The specialists discussed various aspects of modern problems of radiochemistry, radioisotope production, technology of radioisotopes and compounds, activations analysis applications, radionuclides, radioimmunoassays, application of radioisotopes in industry, medicine, biology and agriculture. More than 80 talks were presented in the meeting. (A.A.D.)

  7. Investigation of Insulation Materials for Future Radioisotope Power Systems

    Science.gov (United States)

    Cornell, Peggy A.; Hurwitz, Frances I.; Ellis, David L.; Schmitz, Paul C.

    2013-01-01

    NASA's Radioisotope Power Systems (RPS) Technology Advancement Project is developing next generation high-temperature insulation materials that directly benefit thermal management and improve performance of RPS for future science missions. Preliminary studies on the use of multilayer insulation (MLI) for Stirling convertors used on the Advanced Stirling Radioisotope Generator (ASRG) have shown the potential benefits of MLI for space vacuum applications in reducing generator size and increasing specific power (W/kg) as compared to the baseline Microtherm HT (Microtherm, Inc.) insulation. Further studies are currently being conducted at NASA Glenn Research Center on candidate MLI foils and aerogel composite spacers. This paper presents the method of testing of foils and spacers and experimental results to date.

  8. Investigation of Insulation Materials for Future Radioisotope Power Systems (RPS)

    Science.gov (United States)

    Cornell, Peggy A.; Hurwitz, Frances I.; Ellis, David L.; Schmitz, Paul C.

    2013-01-01

    NASA's Radioisotope Power System (RPS) Technology Advancement Project is developing next generation high temperature insulation materials that directly benefit thermal management and improve performance of RPS for future science missions. Preliminary studies on the use of multilayer insulation (MLI) for Stirling convertors used on the Advanced Stirling Radioisotope Generator (ASRG) have shown the potential benefits of MLI for space vacuum applications in reducing generator size and increasing specific power (W/kg) as compared to the baseline Microtherm HT (Microtherm, Inc.) insulation. Further studies are currently being conducted at NASA Glenn Research Center (GRC) on candidate MLI foils and aerogel composite spacers. This paper presents the method of testing of foils and spacers and experimental results to date.

  9. Radioisotope electric propulsion of sciencecraft to the outer Solar System and near-interstellar space

    International Nuclear Information System (INIS)

    Noble, R.J.

    1999-01-01

    Radioisotopes have been used successfully for more than 25 years to supply the heat for thermoelectric generators on various deep-space probes. Radioisotope electric propulsion (REP) systems have been proposed as low-thrust ion propulsion units based on radioisotope electric generators and ion thrusters. The perceived liability of radioisotope electric generators for ion propulsion is their high mass. Conventional radioisotope thermoelectric generators have a specific mass of about 200 kg/kW of electric power. Many development efforts have been undertaken with the aim of reducing the specific mass of radioisotope electric systems. Recent performance estimates suggest that specific masses of 50 kg/kW may be achievable with thermophotovoltaic and alkali metal thermal-to-electric conversion generators. Powerplants constructed from these near-term radioisotope electric generators and long-life ion thrusters will likely have specific masses in the range of 100 to 200 kg/kW of thrust power if development continues over the next decade. In earlier studies, it was concluded that flight times within the Solar System are indeed insensitive to reductions in the powerplant specific mass, and that a timely scientific program of robotic planetary rendezvous and near-interstellar space missions is enabled by primary electric propulsion once the powerplant specific mass is in the range of 100 to 200 kg/kW. Flight times can be substantially reduced by using hybrid propulsion schemes that combine chemical propulsion, gravity assist, and electric propulsion. Hybrid schemes are further explored in this article to illustrate how the performance of REP is enhanced for Pluto rendezvous, heliopause orbiter, and gravitational lens missions

  10. Pet Health

    Science.gov (United States)

    ... companionship and a feeling of safety to your life. Before getting a pet, think carefully about which ... Gaining or losing a lot of weight quickly Strange behavior Being sluggish and tired Trouble getting up ...

  11. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1983

    International Nuclear Information System (INIS)

    Baker, D.A.

    1984-08-01

    This document lists DOE's radioisotope production and distribution activities by its facilities at Argonne National Laboratory; Pacific Northwest Laboratory; Idaho Operations Office; Los Alamos National Laboratory; Oak Ridge National Laboratory; Savannah River Plant; and UNC Nuclear Industries, Inc. The information is divided into five sections: isotope suppliers, facility contacts, and isotopes or services supplied; lists of customers, suppliers and isotopes purchased; list of isotopes purchased cross-referenced to customer codes; geographic locations of radioisotope customers; and radioisotope sales and transfers - FY 1983

  12. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1986

    International Nuclear Information System (INIS)

    Lamar, D.A.

    1987-10-01

    This document describes radioisotope distribution from DOE facilities to private firms including foreign and other DOE facilities. The information is divided into five sections: (1)isotope suppliers, facility contact, and isotopes or services supplied; (2) customers, suppliers, and isotopes purchased; (3) isotopes purchased cross-referenced with customer numbers; (4) geographic locations of radioisotope customers; and (5) radioisotope sales and transfers for fiscal year 1986

  13. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1984

    Energy Technology Data Exchange (ETDEWEB)

    Baker, D.A.

    1985-08-01

    This edition of the radioisotope customer list was prepared at the request of the Office of Health and Environmental Research (ER-73), Office of Energy Research, Department of Energy (DOE). This document describes radioisotope distribution from DOE facilities to private firms including foreign and other DOE facilities. The information is divided into five sections: (1) isotope suppliers, facility contacts, and isotopes or services supplied; (2) customers, suppliers, and isotopes purchased; (3) isotopes purchased cross-referenced with customer numbers; (4) geographic locations of radioisotope customers; and (5) radioisotope sales and transfers - FY 1984.

  14. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1984

    International Nuclear Information System (INIS)

    Baker, D.A.

    1985-08-01

    This edition of the radioisotope customer list was prepared at the request of the Office of Health and Environmental Research (ER-73), Office of Energy Research, Department of Energy (DOE). This document describes radioisotope distribution from DOE facilities to private firms including foreign and other DOE facilities. The information is divided into five sections: (1) isotope suppliers, facility contacts, and isotopes or services supplied; (2) customers, suppliers, and isotopes purchased; (3) isotopes purchased cross-referenced with customer numbers; (4) geographic locations of radioisotope customers; and (5) radioisotope sales and transfers - FY 1984

  15. Radioisotopes: problems of responsibility arising from medicine

    International Nuclear Information System (INIS)

    Dupon, Michel.

    1978-09-01

    Radioisotopes have brought about great progress in the battle against illnesses of mainly tumoral origin, whether in diagnosis (nuclear medicine) or in treatment (medical radiotherapy). They are important enough therefore to warrant investigation. Such a study is attempted here, with special emphasis, at a time when medical responsibility proceedings are being taken more and more often on the medicolegal problems arising from their medical use. It is hoped that this study on medical responsibility in the use of radioisotopes will have shown: that the use of radioisotopes for either diagnosis or therapy constitutes a major banch of medicine; that this importance implies an awareness by the practitioner of a vast responsibility, especially in law where legislation to ensure protection as strict as in the field of ionizing radiations is lacking. The civil responsibility of doctors who use radioisotopes remains to be defined, since for want of adequate jurisprudence we are reduced to hypotheses based on general principles [fr

  16. Radioisotope production at PUSPATI - five year programme

    International Nuclear Information System (INIS)

    Yusof Azuddin Ali; Abdul Rahman Mohamad Ali.

    1983-01-01

    Most of the basic laboratory facilities for radioisotopes production at PUSPATI will be commissioned by September 1983. Work on setting up of production and dispensing facilities is in progress as the nuclides being worked on are those that are commonly used in medical applications, such as Tc-99m, I-131, P-32 and other nuclides such as Na-24 and K-42. Kits for compounds labelled with Tc-99m such as Stannous Pyrophosphate, Sulfur Colloid and Stannous Glucoheptonate are being prepared. The irradiation facilities available now for radioisotope production at the PUSPATI TRIGA Reactor include a central thimble (flux density 1 x 10 13 n.cm -2 S -1 ) and a rotary specimen rack (flux density 0.2 x 10 13 n.cm -1 S -1 ). Irradiation schedules and target handling techniqes are discussed. Plans for radioisotope production at PUSPATI over the period of 1983-1987, based on present demand for radioisotope, are also explained. (author)

  17. Practical applications of short-lived radioisotopes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1963-01-15

    The advantages of the use of short-lived radioisotopes in agriculture, food industry and medicine as well as some industrial uses are discussed. Methods for isotope production in small research reactors and laboratories are presented

  18. Pet Allergy Quiz

    Science.gov (United States)

    ... Treatments ▸ Allergies ▸ Pet Allergy ▸ Pet Allergy Quiz Share | Pet Allergy Quiz More than half of U.S. households ... cat family. Yet, millions of people suffer from pet allergies. Take this quiz to test your knowledge ...

  19. Health physics and quality control management of a cyclotron-based PET facility

    International Nuclear Information System (INIS)

    Jerabek, P.A.

    1995-01-01

    This paper provides an overview of the operation and management of a Positron Emission Tomography (PET) facility at the University of Texas. The facility components are discussed from an operations perspective with an emphasis on devices, and on practices and procedures which are implemented to ensure that personnel exposures are as low as reasonably achievable. The cyclotron-based PET facility uses in-house production of PET radioisotopes for preparation of radiopharmaceuticals. A combination of specially designed cyclotron equipped devices, radiopharmaceutical preparation devices, and shielded devices along with health physics practices have helped to make PET operations become routine

  20. Competitive advantage of PET/MRI

    Energy Technology Data Exchange (ETDEWEB)

    Jadvar, Hossein, E-mail: jadvar@usc.edu; Colletti, Patrick M.

    2014-01-15

    Multimodality imaging has made great strides in the imaging evaluation of patients with a variety of diseases. Positron emission tomography/computed tomography (PET/CT) is now established as the imaging modality of choice in many clinical conditions, particularly in oncology. While the initial development of combined PET/magnetic resonance imaging (PET/MRI) was in the preclinical arena, hybrid PET/MR scanners are now available for clinical use. PET/MRI combines the unique features of MRI including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most evidence for the potential clinical utility of PET/MRI is based on studies performed with side-by-side comparison or software-fused MRI and PET images. Data on distinctive utility of hybrid PET/MRI are rapidly emerging. There are potential competitive advantages of PET/MRI over PET/CT. In general, PET/MRI may be preferred over PET/CT where the unique features of MRI provide more robust imaging evaluation in certain clinical settings. The exact role and potential utility of simultaneous data acquisition in specific research and clinical settings will need to be defined. It may be that simultaneous PET/MRI will be best suited for clinical situations that are disease-specific, organ-specific, related to diseases of the children or in those patients undergoing repeated imaging for whom cumulative radiation dose must be kept as low as reasonably achievable. PET/MRI also offers interesting opportunities for use of dual modality probes. Upon clear definition of clinical utility, other important and practical issues related to business operational model, clinical workflow and reimbursement will also be resolved.

  1. Competitive advantage of PET/MRI.

    Science.gov (United States)

    Jadvar, Hossein; Colletti, Patrick M

    2014-01-01

    Multimodality imaging has made great strides in the imaging evaluation of patients with a variety of diseases. Positron emission tomography/computed tomography (PET/CT) is now established as the imaging modality of choice in many clinical conditions, particularly in oncology. While the initial development of combined PET/magnetic resonance imaging (PET/MRI) was in the preclinical arena, hybrid PET/MR scanners are now available for clinical use. PET/MRI combines the unique features of MRI including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most evidence for the potential clinical utility of PET/MRI is based on studies performed with side-by-side comparison or software-fused MRI and PET images. Data on distinctive utility of hybrid PET/MRI are rapidly emerging. There are potential competitive advantages of PET/MRI over PET/CT. In general, PET/MRI may be preferred over PET/CT where the unique features of MRI provide more robust imaging evaluation in certain clinical settings. The exact role and potential utility of simultaneous data acquisition in specific research and clinical settings will need to be defined. It may be that simultaneous PET/MRI will be best suited for clinical situations that are disease-specific, organ-specific, related to diseases of the children or in those patients undergoing repeated imaging for whom cumulative radiation dose must be kept as low as reasonably achievable. PET/MRI also offers interesting opportunities for use of dual modality probes. Upon clear definition of clinical utility, other important and practical issues related to business operational model, clinical workflow and reimbursement will also be resolved. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  2. Competitive advantage of PET/MRI

    International Nuclear Information System (INIS)

    Jadvar, Hossein; Colletti, Patrick M.

    2014-01-01

    Multimodality imaging has made great strides in the imaging evaluation of patients with a variety of diseases. Positron emission tomography/computed tomography (PET/CT) is now established as the imaging modality of choice in many clinical conditions, particularly in oncology. While the initial development of combined PET/magnetic resonance imaging (PET/MRI) was in the preclinical arena, hybrid PET/MR scanners are now available for clinical use. PET/MRI combines the unique features of MRI including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most evidence for the potential clinical utility of PET/MRI is based on studies performed with side-by-side comparison or software-fused MRI and PET images. Data on distinctive utility of hybrid PET/MRI are rapidly emerging. There are potential competitive advantages of PET/MRI over PET/CT. In general, PET/MRI may be preferred over PET/CT where the unique features of MRI provide more robust imaging evaluation in certain clinical settings. The exact role and potential utility of simultaneous data acquisition in specific research and clinical settings will need to be defined. It may be that simultaneous PET/MRI will be best suited for clinical situations that are disease-specific, organ-specific, related to diseases of the children or in those patients undergoing repeated imaging for whom cumulative radiation dose must be kept as low as reasonably achievable. PET/MRI also offers interesting opportunities for use of dual modality probes. Upon clear definition of clinical utility, other important and practical issues related to business operational model, clinical workflow and reimbursement will also be resolved

  3. PET applications in pediatrics

    Energy Technology Data Exchange (ETDEWEB)

    Shulkin, B. L. [Ann Arbor, Univ. of Michigan Medical Center (United States). Pediatric Nuclear Medicine Section

    1997-12-01

    This article summarizes the major PET studies which have been performed in pediatric patients to elucidate and characterize diseases and normal development. Issues special for the application of the technique in children, such as dosimetry, patient preparation, and image acquisition are discussed. Studies of central nervous system (CNS) development and pathology, including epilepsy, intraventricular hemorrhage, neonatal asphyxia, tumors, and effects on the CNS from treatment of other tumors are reviewed. These have contributed information fundamental to their understanding of CNS development and pathology. PET investigations into the pathophysiology of congenital heart disease have begun and hold great promise to aid their understanding of these conditions. The second major area in which PET has been applied is the study of non CNS neoplasms. Neuroblastoma has been investigated with tracers which explore basic biochemical features which characterize this tumor, as well as with tracers which explore biochemical events relatively specific for this malignancy. Other common and uncommon tumors of childhood are discussed. The PET technique has been shown useful for answering questions of clinical relevance for the management of these uncommon neoplasms. PET is likely to continue to aid their understanding of many pediatric diseases and may gain more widespread clinical acceptance as the technology continues to disseminate rapidly.

  4. Studies on application of radiation and radioisotopes

    International Nuclear Information System (INIS)

    Kim, Jae Rok; Lee, Ji Bok; Lee, Yeong Iil; Jin, Joon Ha; Beon, Myeong Uh; Park, Kyeong Bae; Han, Heon Soo; Jeong, Yong Sam; Uh, Jong Seop; Kang, Kyeong Cheol; Cho, Han Ok; Song, Hui Seop; Yoon, Byeong Mok; Jeon, Byeong Jin; Park, Hong Sik; Kim, Jae Seong; Jeong, Un Soo; Baek, Sam Tae; Cho, Seong Won; Jeon, Yeong Keon; Kim, Joon Yeon; Kwon, Joong Ho; Kim, Ki Yeop; Yang, Jae Seung; No, Yeong Chang; Lee, Yeong Keun; Shin, Byeong Cheol; Park, Sang Joon; Hong, Kwang Pyo; Cho, Seung Yeon; Kang, Iil Joon; Cho, Seong Ki; Jeong, Yeong Joo; Park, Chun Deuk; Lee, Yeong Koo; Seo, Chun Ha; Han, Kwang Hui; Shin, Hyeon Young; Kim, Jong Kuk; Park, Soon Chul; Shin, In Cheol; Lee, Sang Jae; Lee, Ki Un; Lim, Yong Taek; Park, Eung Uh; Kim, Dong Soo; Jeon, Sang Soo

    1993-05-01

    With the completion of construction of KMRR, the facility and technology of radiation application will be greatly improved. This study was performed as follows; (1) Studies on the production and application of radioisotopes. (2) The development of radiation processing technology. (3) The application of Irradiation techniques for food preservation and process improvement. (4) Studies on the radiation application for the development of genetic resources (5) Development of the radioisotope (RI) production facilities for Korea Multipurpose Research Reactor (KMRR)

  5. Technical diagnosis of industrial plants with radioisotopes

    International Nuclear Information System (INIS)

    Hartmann, G.

    1984-01-01

    A survey is given of the application of radioisotopes in technical diagnosis of industrial plants. Proceeding from the economic importance and the state of the art of radioisotope applications, the principles of tracer techniques are outlined including topical examples of application such as passage of coal through a steam generator, wear in impact crashing of coal, wear and corrosion in pipelines, testing the effective cross section of pipes, and investigations of microstructures. Limits and restrictions of applications are briefly discussed

  6. Radioisotope applications in petroleum and gas industries

    International Nuclear Information System (INIS)

    Castagnet, A.C.; Agudo, E.G.; Duarte, U.

    1974-01-01

    The principal radioisotopic technique used for studying and /or controling the drilling, completion, treatment and oil well secondary recovery operations are described. In this cases the radioisotopes are employed almost exclusively as 'markers', in the form of localized and dispersed tracers. The growing acceptance of these techniques is essentially, a consequence of the confidence in the reliability of the data and conclusions derived from their application

  7. Cost-benefit aspects of radioisotope methods

    International Nuclear Information System (INIS)

    Jankowski, L.

    1986-01-01

    The cost-benefit relations in the complex application of radioisotpe techniques increased in the last years to up to 1/10 to 1/15. The most essential cause of this trend is the increase of the capacity of production processes, controlled and automatized by means of radioisotopes, and the solution of qualitatively new technological problems of a high economic relevance. A collection of statistical data about the expediture and benefit of different radioisotopes techniques is presented. (author)

  8. Radioisotope tracers in industrial flow studies

    International Nuclear Information System (INIS)

    Easey, J.F.

    1987-01-01

    The scope of radioisotope tracer work carried out by ANSTO has involved most sectors of Australian industry including iron and steel coal, chemical, petrochemical, natural gas, metallurgical, mineral, power generation, liquified air plant, as well as port authorities, water and sewerage instrumentalities, and environmental agencies. A major class of such studies concerns itself with flow and wear studies involving industrial equipment. Some examples are discussed which illustrate the utility of radioisotope tracer techniques in these applications

  9. Positron Emission Tomography (PET)

    International Nuclear Information System (INIS)

    Welch, M.J.

    1990-01-01

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET. 22 figs

  10. Positron Emission Tomography (PET)

    Energy Technology Data Exchange (ETDEWEB)

    Welch, M.J.

    1990-01-01

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET. 22 figs.

  11. Positron Emission Tomography (PET)

    Science.gov (United States)

    Welch, M. J.

    1990-01-01

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET.

  12. Pet in Clinical oncology

    International Nuclear Information System (INIS)

    Hunsche, A.; Grossman, G.; Santana, M.; Santana, C.; Halkar, R.; Garcia, E.

    2003-01-01

    The utility of the PET (positron emission tomography in clinical oncology has been recognized for more than two decades, locating it as a sensible technique for the diagnosis and the prognosis stratification of the oncology patients. The sensitivity and specificity of the PET in comparation to other image studies have demonstrated to be greater. For some years, there was a restriction of PET because of the high cost of the equipment and the cyclotrons. Nevertheless, the relation of cost/benefits is considered as a priority as this technique offers important clinical information. In this article the results observed when using it in diverse types of cancer, as well as the effectiveness shown in the pre-operating evaluation, the evaluation of residual disease, diagnosis of recurrences, pursuit and prognosis stratification of the patients with cancer. (The author)

  13. Site Specific Discrete PEGylation of 124I-Labeled mCC49 Fab′ Fragments Improves Tumor MicroPET/CT Imaging in Mice

    Science.gov (United States)

    Ding, Haiming; Carlton, Michelle M.; Povoski, Stephen P.; Milum, Keisha; Kumar, Krishan; Kothandaraman, Shankaran; Hinkle, George H.; Colcher, David; Brody, Rich; Davis, Paul D.; Pokora, Alex; Phelps, Mitchell; Martin, Edward W.; Tweedle, Michael F.

    2014-01-01

    The tumor-associated glycoprotein-72 (TAG-72) antigen is highly overexpressed in various human adenocarcinomas and anti-TAG-72 monoclonal antibodies, and fragments are therefore useful as pharmaceutical targeting vectors. In this study, we investigated the effects of site-specific PEGylation with MW 2–4 kDa discrete, branched PEGylation reagents on mCC49 Fab′ (MW 50 kDa) via in vitro TAG72 binding, and in vivo blood clearance kinetics, biodistribution, and mouse tumor microPET/CT imaging. mCC49Fab′ (Fab′-NEM) was conjugated at a hinge region cysteine with maleimide-dPEG12-(dPEG24COOH)3 acid (Mal-dPEG-A), maleimide-dPEG12-(dPEG12COOH)3 acid (Mal-dPEG-B), or maleimide-dPEG12-(m-dPEG24)3 (Mal-dPEG-C), and then radiolabeled with iodine-124 (124I) in vitro radioligand binding assays and in vivo studies used TAG-72 expressing LS174T human colon carcinoma cells and xenograft mouse tumors. Conjugation of mCC49Fab′ with Mal-dPEG-A (Fab′-A) reduced the binding affinity of the non PEGylated Fab′ by 30%; however, in vivo, Fab′-A significantly lengthened the blood retention vs Fab′-NEM (47.5 vs 28.1%/ID at 1 h, 25.1 vs 8.4%/ID at 5 h, p Fab′-NEM by 70%, blood retention, microPET/CT imaging tumor signal intensity, and residual 72 h tumor concentration by 49% (3.83 ± 1.50 vs 1.97 ± 0.29%ID/g, p < 0.05) and 63% (3.83 ± 1.50 vs 1.42 ± 0.35%ID/g, p < 0.05), respectively. We conclude that remarkably subtle changes in the structure of the PEGylation reagent can create significantly altered biologic behavior. Further study is warranted of conjugates of the triple branched, negatively charged Mal-dPEG-A. PMID:24175669

  14. Medical Radioisotopes Production Without A Nuclear Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Van der Keur, H.

    2010-05-15

    This report is answering the key question: Is it possible to ban the use of research reactors for the production of medical radioisotopes? Chapter 2 offers a summarized overview on the history of nuclear medicine. Chapter 3 gives an overview of the basic principles and understandings of nuclear medicine. The production of radioisotopes and its use in radiopharmaceuticals as a tracer for imaging particular parts of the inside of the human body (diagnosis) or as an agent in radiotherapy. Chapter 4 lists the use of popular medical radioisotopes used in nuclear imaging techniques and radiotherapy. Chapter 5 analyses reactor-based radioisotopes that can be produced by particle accelerators on commercial scale, other alternatives and the advantages of the cyclotron. Chapter 6 gives an overview of recent developments and prospects in worldwide radioisotopes production. Chapter 7 presents discussion, conclusions and recommendations, and is answering the abovementioned key question of this report: Is it possible to ban the use of a nuclear reactor for the production of radiopharmaceuticals? Is a safe and secure production of radioisotopes possible?.

  15. Early radioisotope uses in Mexico

    International Nuclear Information System (INIS)

    Segovia, N.; Tejera, A.; Bulbulian, S.; Palma, F.

    1991-10-01

    Mexico is traditionally a mining country and the first information about the presence of uranium is related to mine exploitation. Around 1945 when uranium became economically important, a rumor had spread that large amounts of black ceramics from Oaxaca were being purchased and sent abroad because of its assumed high uranium content. It was only in 1949 when minerals containing thorium and uranium were declared by law as 'National Reserves'. In those years a radium emanation plant was installed at the 'Hospital General' in Mexico City with the main purpose of carrying out radon seed implantation in tumors. In the fifties a radium dial painting facility was operating in the city of Toluca some 70 km from Mexico City. In 1955, when the National Commission of Nuclear Energy (CNEN) was founded by a government decree, two main activities were in sight: a training program on 'Radioisotope Techniques and Nuclear Instrumentation' and the creation of specialized laboratories. In this paper a general description of these events and undertakings spanning the decades 1940 to 1970 is given. (Author)

  16. Radioisotopes In Animal Production Research

    International Nuclear Information System (INIS)

    Eduvie, L.O.

    1994-05-01

    Animal productivity may be measured among others, in terms of two important physiological processes of reproduction and growth each of which involves a number of integrated disciplines. Both physiological processes are controlled by interactions of genotype and environment. Reproduction essentially involves complex physiological processes controlled by secretions of endocrine glands known as hormones. On the other hand growth is determined largely by availabilty of essential nutrients. In order to achieve good reproductive and growth rates adequate and constant nutrition for livestock include pasture, cereals, tubers and their by-products as well as industrial by-products. While reproduction is essential to provide the required number and replacement of livestock, growth guarantees availability of meat. Another aspect of livestock production is disease control. An animal needs a good health to adequately express its genetic make up and utilize available nutrition. Research in animal production is aimed at improving all aspects of productivity of livestock which include reproduction, growth, milk production, egg production, good semen etc. of livestock. In order to achieve this an understanding of the biochemical and physiological processes occurring in the animal itself, and in the feedstuff fed to the animal as well as the aetiology and control of diseases affecting the animal among other factors, is desirable. A number of methods of investigation have evolved with time. These include colorimetry, spectrophotometry, chromatography, microscopy and raidoisotopic tracer methods. While most of these methods are cumbersome and use equipment with low precision, radioisotopic tracer methods utilize equipment with relatively high precision

  17. Development of radioisotope tracer technology

    International Nuclear Information System (INIS)

    Jin, Joon Ha; Lee, Myun Joo; Jung, Sung Hee; Park, Soon Chul; Lim, Dong Soon; Kim, Jae Ho; Lee, Jae Choon; Lee, Doo Sung; Cho, Yong Suk; Shin, Sung Kuan

    2000-04-01

    The purpose of this study is to develop the radioisotope tracer technology, which can be used in solving industrial and environmental problems and to build a strong tracer group to support the local industries. In relation to the tracer technology in 1999, experiments to estimate the efficiencies of a sludge digester of a waste water treatment plant and a submerged biological reactor of a dye industry were conducted. As a result, the tracer technology for optimization of facilities related to wastewater treatment has been developed and is believed to contribute to improve their operation efficiency. The quantification of the experimental result was attempted to improve the confidence of tracer technology by ECRIN program which basically uses the MCNP simulation principle. Using thin layer activation technique, wear of tappet shim was estimated. Thin layer surface of a tappet shim was irradiated by proton beam and the correlation between the measured activity loss and the amount of wear was established. The equipment was developed to adjust the energy of proton which collides with the surface of tappet. The tracer project team has participated into the tracer test for estimating the efficiency of RFCC system in SK cooperation. From the experiment the tracer team has obtained the primary elements to be considered for judging the efficiency of RFCC unit. By developing the tracer techniques to test huge industrial units like RFCC, the tracer team will be able to support the local industries that require technical services to solve any urgent trouble. (author)

  18. Early radioisotope uses in Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Segovia, N; Tejera, A; Bulbulian, S; Palma, F

    1991-10-15

    Mexico is traditionally a mining country and the first information about the presence of uranium is related to mine exploitation. Around 1945 when uranium became economically important, a rumor had spread that large amounts of black ceramics from Oaxaca were being purchased and sent abroad because of its assumed high uranium content. It was only in 1949 when minerals containing thorium and uranium were declared by law as 'National Reserves'. In those years a radium emanation plant was installed at the 'Hospital General' in Mexico City with the main purpose of carrying out radon seed implantation in tumors. In the fifties a radium dial painting facility was operating in the city of Toluca some 70 km from Mexico City. In 1955, when the National Commission of Nuclear Energy (CNEN) was founded by a government decree, two main activities were in sight: a training program on 'Radioisotope Techniques and Nuclear Instrumentation' and the creation of specialized laboratories. In this paper a general description of these events and undertakings spanning the decades 1940 to 1970 is given. (Author)

  19. Radiation risk assessment for the transport of radioisotopes using KRI-BGM B(U) type container

    International Nuclear Information System (INIS)

    Cho, Woon-Kap

    2008-01-01

    The radiation risks were estimated for the transportation of radioisotopes using KRI-BGM transport container. KRI-BGM container was specially designed for transportation of large amount of radioisotopes for industrial or medical applications. The container can carry maximum 370 TBq of solid Ir-192, 29.6 TBq of liquid Mo-99 and 37 TBq of liquid I-131 respectively. For the radiation risk assessment, it was assumed that maximum design activity of those radioisotopes was transported. Transportation route is from Daejeon where radioisotopes are produced to Seoul where radioisotopes are consumed. Transport distance is 200 km including highway and downtown area from Daejeon to Seoul. As the transportation conveyance, an ordinary cargo truck is used exclusively. Radiation risks were estimated for incident free and accident condition of transportation and RADTRAN 5.6 was used as the risk assessment tool. For the risk assessment of radioisotopes transportation, various parameters such as population density around transport route, weather condition, probability of specific accidents such as impact, fire, etc. were considered. From the results of this study, the exclusive transportation of radioisotopes using KRI-BGM transport container by truck showed low radiological risks with manageable safety and health consequences. This paper discusses the methods and results of the radiation risks assessment for the radioisotopes transportation by an ordinary truck and presents the expected radiation risks in person-Sv and latent cancer fatalities. (author)

  20. Kinetic modeling in PET imaging of hypoxia

    DEFF Research Database (Denmark)

    Li, Fan; Jørgensen, Jesper Tranekjær; Hansen, Anders E

    2014-01-01

    be used for non-invasive mapping of tissue oxygenation in vivo and several hypoxia specific PET tracers have been developed. Evaluation of PET data in the clinic is commonly based on visual assessment together with semiquantitative measurements e.g. standard uptake value (SUV). However, dynamic PET......Tumor hypoxia is associated with increased therapeutic resistance leading to poor treatment outcome. Therefore the ability to detect and quantify intratumoral oxygenation could play an important role in future individual personalized treatment strategies. Positron Emission Tomography (PET) can...... analysis for PET imaging of hypoxia....

  1. Novel PET and Near Infrared Imaging Probes for the Specific Detection of Bacterial Infections Associated With Cardiac Devices.

    Science.gov (United States)

    Takemiya, Kiyoko; Ning, Xinghai; Seo, Wonewoo; Wang, Xiaojian; Mohammad, Rafi; Joseph, Giji; Titterington, Jane S; Kraft, Colleen S; Nye, Jonathan A; Murthy, Niren; Goodman, Mark M; Taylor, W Robert

    2018-04-13

    The aim of this study was to develop imaging agents to detect early stage infections in implantable cardiac devices. Bacteria ingest maltodextrins through the specific maltodextrin transporter. We developed probes conjugated with either a fluorescent dye (maltohexaose fluorescent dye probe [MDP]) or a F-18 (F18 fluoromaltohexaose) and determined their usefulness in a model of infections associated with implanted cardiac devices. Stainless steel mock-ups of medical devices were implanted subcutaneously in rats. On post-operative day 4, animals were injected with either Staphylococcus aureus around the mock-ups to induce a relatively mild infection or oil of turpentine to induce noninfectious inflammation. Animals with a sterile implant were used as control subjects. On post-operative day 6, either the MDP or F18 fluoromaltohexaose was injected intravenously, and the animals were scanned with the appropriate imaging device. Additional positron emission tomography imaging studies were performed with F18-fluorodeoxyglucose as a comparison of the specificity of our probes (n = 5 to 9 per group). The accumulation of the MDP in the infected rats was significantly increased at 1 h after injection when compared with the control and noninfectious inflammation groups (intensity ratio 1.54 ± 0.07 vs. 1.26 ± 0.04 and 1.20 ± 0.05, respectively; p F18 fluoromaltohexaose and F18 fluorodeoxyglucose significantly accumulated in the infected area 30 min after the injection (maximum standard uptake value ratio 4.43 ± 0.30 and 4.87 ± 0.28, respectively). In control rats, there was no accumulation of imaging probes near the device. In the noninfectious inflammation rats, no significant accumulation was observed with F18 fluoromaltohexaose, but F18 fluorodeoxyglucose accumulated in the mock-up area (maximum standard uptake value 2.53 ± 0.39 vs. 4.74 ± 0.46, respectively; p < 0.05). Our results indicate that maltohexaose-based imaging probes are potentially useful for the

  2. PET/MRI. Challenges, solutions and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Herzog, Hans [Forschungszentrum Juelich (Germany). Inst. of Neuroscience and Medicine - 4

    2012-07-01

    Already from the start of PET/CT integrating positron emission tomography (PET) and computed tomography (CT) in one instrument, there have been considerations how to combine PET and magnetic resonance imaging (MRI) so that their complementary abilities can be utilized in a single investigation. Since classical PET electronics fail in an even weak magnetic field and PET signal processing might disturb high-frequency signals of MRI, it soon became clear that new solutions had to be found to avoid mutual interferences. During the last fifteen years a number of different approaches towards PET/MRI for small animal imaging have been developed by research groups which together with their specific features are summarized in this review. Recently, PET/MRI for human imaging became available as well - this time by industrial initiatives. First some prototypes of BrainPET/MRI were developed followed by commercial products for simultaneous and non-simultaneous whole-body PET/MRI. Although only PET/MRI integrated in one scanner offers the full diversity of complementary multiparametric imaging, there are also promising applications of non-simultaneous sequential PET/MRI. While describing the present instrumentation for human PET/MRI, this review discusses the challenges and promises related to this new imaging technology. (orig.)

  3. Application of PET in breast cancer

    International Nuclear Information System (INIS)

    Noh, Dong Young

    2002-01-01

    Positron emission tomography (PET) is an imaging method that employs radionuclide and tomography techniques. Since 1995, we applied PET not only to the diagnosis of breast cancer but also to the detection of abnormalities in the augmented breast and to the detection of metastasis. Until 2001, we evaluated 242 breast cases by PET at PET center of Seoul National University Hospital. Our group has reported serially at the international journals. In the firtst report, PET showed high sensitivity for detecting breast cancer, both the primary and axillary node metastasis. A total of 27 patients underwent breast operations based on PET results at Seoul National University Hospital from 1995 to 1996. The diagnostic accuracy of PET were 97% for the primary tumor mass and 96% for axillary lymph node metastasis. In case of the breast augmented, PET also showed excellent diagnostic results for primary breast cancer and axillary lymph node metastasis where mammography and ultrasound could not diagnose properly. PET also had outstanding results in the detection of recurrent or metastatic breast cancer(sensitivity 94%, specificity 80%, accuracy 89%). In addition, our study gave some evidence that PET could be applied further to evaluate the growth rate of tumors by measuring SUV, and finally to prognosticated the disease. PET could also be applied to evaluate the response after chemotherapy to measure its metabolic rate and size. In conclsion, PET is a highly sensitive, accurate diagnostic tool for breast cancer of primary lesion in various conditions including metastasis

  4. Radiopharmaceuticals labelled with positron-emitting radioisotopes

    International Nuclear Information System (INIS)

    Comar, D.; Berridge, M.; Maziere, B.; Crouzel, C.

    1982-01-01

    This chapter reviews the preparation of radioisotopes for biochemical and physiological studies and the principal methods for their incorporation into radiopharmaceuticals, while pointing out the problems encountered with their use and considering their medical interest in the following areas: distribution and flow of fluids, metabolic and pharmacokinetic studies. Inorganic and organic radiopharmaceuticals presently in use and most probable to be used in the future are reviewed. It is anticipated that three types of products labelled with 15 O, 13 N, 11 C and 18 F will be developed in the future. The first type includes products which trace general phenomena such as fluid movement or metabolism of sugars, fats and proteins. The compromise between physiological accuracy and imaging technology is discussed in relation to the use of 11 C and 18 F. The second type of product is one to measure more specific parameters such as those of molecular transport kinetics, membrane permeability, cellular pH and receptor-ligand interactions, again with particular reference to 11 C and 18 F. The third type of product discussed is that intended for pharmacology studies, particular reference being made to 68 Ga, 82 Rb. Extensive bibliography. (U.K.)

  5. Current status of radio-isotopes utilization

    Energy Technology Data Exchange (ETDEWEB)

    Singh, M [Banaras Hindu Univ. (India)

    1974-08-01

    Utilization of radioisotopes were reviewed briefly in a categorized manner. In plant biochemistry, long lived radioactive carbon ,/sup 14/C, was applied to clarify such metabolic processes as photosynthesis, respiration and protein synthesis, etc., while radioactive oxygen ,/sup 18/O, was used to study the O/sub 2/ generation mechanism. Radioactive phosphorus ,/sup 32/P, was used to detect the amount, grain size of phosphatic fertilizer as well as the time and depth for better utilization. Radioactive sulphur ,/sup 35/S, and nitrogen ,/sup 15/N, could be of use in studies of protein metabolism in plants. Radioactive tracers of other minerals such as N, P, K, Ca, Mg, Zn, Mo, B, and Co were also used to detect their specific role in plants. Use of radioactive isotopes in protein synthesis and transfer of genetic information was described. Radioactive iodine ,/sup 131/I, binding capacity of milk proteins, and radio trace studies in the iodine turn over in the use of radioactive iodine were summarized.

  6. Comparison of standard and delayed imaging to improve the detection rate of [{sup 68}Ga]PSMA I and T PET/CT in patients with biochemical recurrence or prostate-specific antigen persistence after primary therapy for prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Schmuck, Sebastian; Nordlohne, Stefan; Sohns, Jan M.; Ross, Tobias L.; Bengel, Frank M.; Derlin, Thorsten [Hannover Medical School, Department of Nuclear Medicine, Hannover (Germany); Klot, Christoph A. von [Hannover Medical School, Department of Urology and Urologic Oncology, Hannover (Germany); Henkenberens, Christoph; Christiansen, Hans [Hannover Medical School, Department of Radiation Oncology, Hannover (Germany); Wester, Hans-Juergen [Technische Universitaet Muenchen, Pharmaceutical Radiochemistry, Garching (Germany)

    2017-06-15

    The aim of this study was to assess the value of dual-time point imaging in PET/CT for detection of biochemically recurrent or persistent prostate cancer, using the prostate-specific membrane antigen (PSMA) ligand [{sup 68}Ga]PSMA I and T. 240 patients who underwent a [{sup 68}Ga]PSMA I and T PET/CT in the context of biochemical relapse of prostate cancer were included in this retrospective analysis. Imaging consisted of a standard whole-body PET/CT (1 h p.i.), followed by delayed (3 h p.i.) imaging of the abdomen. PSA-stratified proportions of positive PET/CT results, standardized uptake values and target-to-background ratios were analyzed, and compared between standard and delayed imaging. The overall detection rates of [{sup 68}Ga]PSMA I and T PET/CT were 94.2, 71.8, 58.6, 55.9 and 38.9% for PSA levels of ≥2, 1 to <2, 0.5 to <1, >0.2 to <0.5, and 0.01 to 0.2 ng/mL, respectively. Although the target-to-background ratio improved significantly over time (P < 0.0001), the majority (96.6%) of all lesions suggestive of recurrent disease could already be detected in standard imaging. Delayed imaging at 3 h p.i. exclusively identified pathologic findings in 5.4% (10/184) of abnormal [{sup 68}Ga]PSMA I and T PET/CT scans, and exclusively detected 3.4% (38/1134) of all lesions suggestive of recurrent disease. [{sup 68}Ga]PSMA I and T PET/CT shows high detection rates in patients with prostate-specific antigen persistence or biochemical recurrence of prostate cancer. Delayed imaging can detect lesions with improved contrast compared to standard imaging. However, the impact on detection rates was limited in this study. (orig.)

  7. Radioisotope Production for Medical and Physics Applications

    Science.gov (United States)

    Mausner, Leonard

    2012-10-01

    Radioisotopes are critical to the science and technology base of the US. Discoveries and applications made as a result of the availability of radioisotopes span widely from medicine, biology, physics, chemistry and homeland security. The clinical use of radioisotopes for medical diagnosis is the largest sector of use, with about 16 million procedures a year in the US. The use of ^99Mo/^99mTc generator and ^18F make up the majority, but ^201Tl, ^123I, ^111In, and ^67Ga are also used routinely to perform imaging of organ function. Application of radioisotopes for therapy is dominated by use of ^131I for thyroid malignancies, ^90Y for some solid tumors, and ^89Sr for bone cancer, but production of several more exotic species such as ^225Ac and ^211At are of significant current research interest. In physics ^225Ra is of interest for CP violation studies, and the actinides ^242Am, ^249Bk, and ^254Es are needed as targets for experiments to create superheavy elements. Large amounts of ^252Cf are needed as a fission source for the CARIBU experiment at ANL. The process of radioisotope production is multidisciplinary. Nuclear physics input based on nuclear reaction excitation function data is needed to choose an optimum target/projectile in order to maximize desired isotope production and minimize unwanted byproducts. Mechanical engineering is needed to address issues of target heating, induced mechanical stress and material compatibility of target and claddings. Radiochemists are involved as well since chemical separation to purify the desired final radioisotope product from the bulk target and impurities is also usually necessary. Most neutron rich species are produced at a few government and university reactors. Other radioisotopes are produced in cyclotrons in the commercial sector, university/hospital based facilities, and larger devices at the DOE labs. The landscape of US facilities, the techniques involved, and current supply challenges will be reviewed.

  8. Repeatability of quantitative parameters of 18F-fluoride PET/CT and biochemical tumour and specific bone remodelling markers in prostate cancer bone metastases.

    Science.gov (United States)

    Wassberg, Cecilia; Lubberink, Mark; Sörensen, Jens; Johansson, Silvia

    2017-12-01

    18F-fluoride PET/CT exhibits high sensitivity to delineate and measure the extent of bone metastatic disease in patients with prostate cancer. 18F-fluoride PET/CT could potentially replace traditional bone scintigraphy in clinical routine and trials. However, more studies are needed to assess repeatability and biological uptake variation. The aim of this study was to perform test-retest analysis of quantitative PET-derived parameters and blood/serum bone turnover markers at the same time point. Ten patients with prostate cancer and verified bone metastases were prospectively included. All underwent two serial 18F-fluoride PET/CT at 1 h post-injection. Up to five dominant index lesions and whole-body 18F-fluoride skeletal tumour burden were recorded per patient. Lesion-based PET parameters were SUVmax, SUVmean and functional tumour volume applying a VOI with 50% threshold (FTV 50% ). The total skeletal tumour burden, total lesion 18F-fluoride (TLF), was calculated using a threshold of SUV of ≥15. Blood/serum biochemical bone turnover markers obtained at the time of each PET were PSA, ALP, S-osteocalcin, S-beta-CTx, 1CTP and BAP. A total of 47 index lesions and a range of 2-122 bone metastases per patient were evaluated. Median time between 18F-fluoride PET/CT was 7 days (range 6-8 days). Repeatability coefficients were for SUVmax 26%, SUVmean 24%, FTV 50% for index lesions 23% and total skeletal tumour burden (TLF) 35%. Biochemical bone marker repeatability coefficients were for PSA 19%, ALP 23%, S-osteocalcin 18%, S-beta-CTx 22%, 1CTP 18% and BAP 23%. Quantitative 18F-fluoride uptake and simultaneous biochemical bone markers measurements are reproducible for prostate cancer metastases and show similar magnitude in test-retest variation.

  9. Design of a 1 MeV 3He+ RFQ for the SAIC PET accelerator facility

    International Nuclear Information System (INIS)

    Cornelius, W.D.; Young, P.E.

    1993-01-01

    The novel design of a 1 MeV 3 He + radiofrequency quadrupole (RFQ) accelerator is discussed. This RFQ is the first segment of an accelerator for the production of radioisotopes for positron emission tomography (PET) applications. This RFQ is unusual in that two specific innovations were incorporated into the design. The mechanical design is a hybrid of conventional four-vane and four-rod geometries. This hybridization reduces the physical dimensions of the accelerator without sacrificing too much in rf efficiency and has the added benefit of reducing the sensitivity to mechanical alignment errors. In addition, the beam dynamics of the last few cells was modified to tailor the output beam parameters to improve the beam transport through the next accelerator section. The details of the mechanical structure, the mechanical and electrical alignment experiences, and a comparison of the theoretical and experimental performance of this accelerator are also discussed. (orig.)

  10. Clinical Application of F-18 FDG PET (PET/CT) in Malignancy of Unknown Origin

    International Nuclear Information System (INIS)

    Kim, Byung Il

    2008-01-01

    Diagnosis of primary origin site in the management of malignancy of unknown origin (MUO) is the most important issue. According to the histopathologic subtype of primary lesion, specialized treatment can be given and survival gain is expected. F-18 FDG PET (PET/CT) has been estimated as useful in detection of primary lesion with high sensitivity and moderate specificity. F-18 FDG PET (PET/CT) study before conventional studies is also recommended because it has high diagnostic performance compared to conventional studies. Although there has few data, F-18 FDG PET (PET/CT) is expected to be useful in diagnosis of recurrence, restaging, evaluation of treatment effect, considering that PET (PET/CT) has been reported as useful in other malignancies

  11. Development of Kabila rocket: A radioisotope heated thermionic plasma rocket engine

    Directory of Open Access Journals (Sweden)

    Kalomba Mboyi

    2015-04-01

    Full Text Available A new type of plasma rocket engine, the Kabila rocket, using a radioisotope heated thermionic heating chamber instead of a conventional combustion chamber or catalyst bed is introduced and it achieves specific impulses similar to the ones of conventional solid and bipropellant rockets. Curium-244 is chosen as a radioisotope heat source and a thermal reductive layer is also used to obtain precise thermionic emissions. The self-sufficiency principle is applied by simultaneously heating up the emitting material with the radioisotope decay heat and by powering the different valves of the plasma rocket engine with the same radioisotope decay heat using a radioisotope thermoelectric generator. This rocket engine is then benchmarked against a 1 N hydrazine thruster configuration operated on one of the Pleiades-HR-1 constellation spacecraft. A maximal specific impulse and power saving of respectively 529 s and 32% are achieved with helium as propellant. Its advantages are its power saving capability, high specific impulses and simultaneous ease of storage and restart. It can however be extremely voluminous and potentially hazardous. The Kabila rocket is found to bring great benefits to the existing spacecraft and further research should optimize its geometric characteristics and investigate the physical principals of its operation.

  12. Radioisotopes production for applications on the health

    International Nuclear Information System (INIS)

    Monroy G, F.; Alanis M, J.

    2010-01-01

    In the Radioactive Materials Department of the Instituto Nacional de Investigaciones Nucleares (ININ) processes have been studied and developed for the radioisotopes production of interest in the medicine, research, industry and agriculture. In particular five new processes have been developed in the last 10 years by the group of the Radioactive Materials Research Laboratory to produce: 99 Mo/ 99m Tc and 188 W/ 188 Re generators, the radio lanthanides: 151 Pm, 147 Pm, 161 Tb, 166 Ho, 177 Lu, 131 I and the 32 P. All these radioisotopes are artificial and they can be produced in nuclear reactors and some of them in particle accelerators. The radioisotope generators are of particular interest, as those of 99 Mo/ 99m Tc and 188 W/ 188 Re presented in this work, because they are systems that allow to produce an artificial radioisotope of interest continually, in these cases the 99m Tc and the 188 Re, without the necessity of having a nuclear reactor or an particle accelerator. They are compact systems armored and sure perfectly of manipulating that, once the radioactive material has decayed, they do not present radiological risk some for the environment and the population. These systems are therefore of supreme utility in places where it is not had nuclear reactors or with a continuous radioisotope supply, due to their time of decaying, for its cost or for logistical problems in their supply, like it is the case of many hospital centers, of research or industries in our country. (Author)

  13. A Review of the Production of ''Special'' Radioisotopes

    International Nuclear Information System (INIS)

    Stang, L.G. Jr.

    1963-01-01

    'special' radioisotopes and tagged beads available from Brookhaven are reviewed very briefly, including recent unpublished work concerned with the successful development of an Al 28 ''generator'', the production of Sc 47 , the increase in Mg 28 specific activity to 40 mc/g, and the use of Li 6 H 2 to effect (n, particle) reactions. (author) [fr

  14. RADIOISOTOPE INVENTORY FOR TSPA-SR

    International Nuclear Information System (INIS)

    Leigh, C.; Rechard, R.

    2001-01-01

    The total system performance assessment for site recommendation (TSPA-SR), on Yucca Mountain, as a site (if suitable) for disposal of radioactive waste, consists of several models. The Waste Form Degradation Model (i.e, source term) of the TSPA-SR, in turn, consists of several components. The Inventory Component, discussed here, defines the inventory of 26 radioisotopes for three representative waste categories: (1) commercial spent nuclear fuel (CSNF), (2) US Department of Energy (DOE) spent nuclear fuel (DSNF), and (3) high-level waste (HLW). These three categories are contained and disposed of in two types of waste packages (WPs)--CSNF WPs and co-disposal WPs, with the latter containing both DSNF and HLW. Three topics are summarized in this paper: first, the transport of radioisotopes evaluated in the past; second, the development of the inventory for the two WP types; and third, the selection of the most important radioisotopes to track in TSPA-SR

  15. Seven Things to Know about Radioisotopes

    International Nuclear Information System (INIS)

    Henriques, Sasha

    2014-01-01

    Each atomic element knows exactly how many protons and neutrons it needs at its centre (nucleus) in order to be stable (stay in its elemental form). Radioisotopes are atomic elements that do not have the correct proton to neutron ratio to remain stable. With an unbalanced number of protons and neutrons, energy is given off by the atom in an attempt to become stable. For example, a stable carbon atom has six protons and six neutrons. Whereas its unstable (and therefore radioactive) isotope carbon-14, has six protons and eight neutrons. Carbon-14 and all other unstable elements are called radioisotopes. This movement towards stability, which involves emitting energy from the atom in the form of radiation, is known as radioactive decay. This radiation can be tracked and measured, making radioisotopes very useful in industry, agriculture and medicine

  16. Diffusion of Implanted Radioisotopes in Solids

    CERN Multimedia

    2002-01-01

    Implantation of radioisotopes into metal and semiconductor samples is performed. The implanted isotope or its decay-product should have a half-life long enough for radiotracer diffusion experiments. Such radioisotopes are utilized to investigate basic diffusion properties in semiconductors and metals and to improve our understanding of the atomic mechanisms of diffusion. For suitably chosen systems the combination of on-line production and clean implantation of radioisotopes at the ISOLDE facility opens new possibilities for diffusion studies in solids. \\\\ \\\\ The investigations are concentrated on diffusion studies of $^{195}$Au in amorphous materials. The isotope $^{195}$Au was obtained from the mass 195 of the mercury beam. $^{195}$Hg decays into $^{195}$Au which is a very convenient isotope for diffusion experiments. \\\\ \\\\ It was found that $^{195}$Au is a slow diffusor in amorphous Co-Zr alloys, whereas Co is a fast diffusor in the same matrix. The ``asymmetry'' in the diffusion behaviour is of considerab...

  17. Safety regulations for radioisotopes, etc. (interim report)

    International Nuclear Information System (INIS)

    1980-01-01

    An (interim) report by an ad hoc expert committee to the Nuclear Safety Commission, on the safety regulations for radioisotopes, etc., was presented. For the utilization of radioisotopes, etc., there is the Law Concerning Prevention of Radiation Injury Due to Radioisotopes, etc. with the advances in this field and the improvement in international standards, the regulations by the law have been examined. After explaining the basic ideas of the regulations, the problems and countermeasures in the current regulations are described: legal system, rationalization in permission procedures and others, inspection on RI management, the system of the persons in charge of radiation handling, RI transport, low-level radioactive wastes, consumer goods, definitions of RIs, radiation and sealed sources, regulations by group partitioning, RI facilities, system of personnel exposure registration, entrusting of inspection, etc. to private firms, and reduction in the works for permission among governmental offices. (author)

  18. Research reactor production of radioisotopes for medical use

    International Nuclear Information System (INIS)

    Mani, R.S.

    1985-01-01

    More than 70% of all radioisotopes applied in medical diagnosis and research are currently produced in research reactors. Research reactors are also an important source of certain radioisotopes, such as 60 Co, 90 Y, 137 Cs and 198 Au, which are employed in teletherapy and brachytherapy. For regular medical applications, mainly 29 radionuclides produced in research reactors are used. These are now produced on an 'industrial scale' by many leading commercial manufacturers in industrialized countries as well as by national atomic energy establishments in developing countries. Five main neutron-induced reactions have been employed for the regular production of these radionuclides, namely: (n,γ), (n,p), (n,α), (n,γ) followed by decay, and (n, fission). In addition, the Szilard-Chalmers process has been used in low- and medium-flux research reactors to enrich the specific activity of a few radionuclides (mainly 51 Cr) produced by the (n,γ) reaction. Extensive work done over the last three decades has resulted in the development of reliable and economic large-scale production methods for most of these radioisotopes and in the establishment of rigorous specifications and purity criteria for their manifold applications in medicine. A useful spectrum of other radionuclides with suitable half-lives and low to medium toxicity can be produced in research reactors, with the requisite purity and specific activity and at a reasonable cost, to be used as tracers. Thanks to the systematic work done in recent years by many radiopharmaceutical scientists, the radionuclides of several elements, such as arsenic, selenium, rhenium, ruthenium, palladium, cadmium, tellurium, antimony, platinum, lead and the rare earth elements, which until recently were considered 'exotic' in the biomedical field, are now gaining attention. (author)

  19. Utilization of Pets in a Hospice Program.

    Science.gov (United States)

    Doyle, Kathleen; Kukowski, Thomas

    1989-01-01

    The therapeutic use of animals with specific populations has gained increased attention and interest. Pet placement in special settings such as prisons, mental institutions and hospices have shown beneficial results. Development of a pet visitation program requires specific planning and organization. (JD)

  20. The IAEA Activities on Supporting the Use of Unsealed Radioisotopes for the Treatment of Malignant and Benign Diseases

    International Nuclear Information System (INIS)

    Zaknun, J.J.; Pillai, M.R.A.; Palm, S.; Dondi, M.

    2009-01-01

    pre- phase-I (micro dosing study) provided needed pre-clinical information on the bio-distribution of the particular 177 Lu-EDTMP formulation that has been produced under GMP conditions by Polatom, Poland. This data was used to design a phase I/II clinical trial on the biological safety and efficacy of 177 Lu-EDTMP as a bone pain palliating radiopharmaceutical. To better assess toxicity results during the clinical phase-I investigation, a novel approach was introduced to predict patients' individual bone marrow absorbed dose. In close collaboration with another NA Section, namely 'Dosimetry and Medical Radiation Physics' (DMRP), a consultancy of worldwide leading medical physicists was called to discuss and finalize a user- friendly programme to predict the bone marrow absorbed dose by means of a micro-dosing of the therapeutic radiopharmaceutical followed by 24 hours whole body scintigraphic imaging. Preliminary results based on urine analysis and whole body imaging up to 7 days post injection indicate a bio-distribution similar to that of Samarium-153 EDTMP. With regard to short and medium term projects on therapy with unsealed radioisotopes, joint effort among leading institutions world-wide with the support of Department of Nuclear Sciences and Applications is aiming at enhancing Member States' self-reliance in utilising a selection of novel radiopharmaceuticals, proven clinically effective and safe, to manage chemotherapy-resistant tumours. Ga-68 radiopharmaceuticals as a powerful diagnostic tool for Positron Emission Tomography (PET) has been identified as an important application for the management of NET and a variety of Somatostatin receptor (SSR) expressing tumours. In conjunction with high specific-activity Lu-177 loaded to targeting peptides, e.g. SSR analogues or monoclonal antibodies a synergy is created to provide patient-specific, individually designed treatment approaches. The IAEA acknowledges professionals from all associated fields for their

  1. Radioisotopes in non-destructive testing

    International Nuclear Information System (INIS)

    Domanus, J.C.

    1976-12-01

    After defining nondestructive testing (NDT) and comparing this concept with destructive testing, a short description is given of NDT methods other than radiologic. The basic concepts of radiologic methods are discussed and the principles of radiography are explained. Radiation sources and gamma radiography machines are next reviewed and radiographic inspection of weldings and castings is described. A brief description is given of the radiographic darkroom and accessories. Other radioisotope methods, such as neutron radiography, are shortly reviewed. Cost estimations for radioisotopic equipment conclude the report. (author)

  2. Random-process excursions in radioisotope instruments

    International Nuclear Information System (INIS)

    Galochkin, D.V.; Polovko, S.A.

    1984-01-01

    Approximate expressions are derived for the mathematical expectation, variance, and distribution of the durations of the excursions of the output signal from a ratemeter in a radioisotope relay instrument. The tabulated comparison of results from Monte Carlo simulation and analytical calculation shows good agreement over the mean value and the variance of the excursion duration for T 0.2 sec as calculated and as obtained by Monte Carlo simulation with a computer using 5000 realizations. It is suggested that the results should be used in choosing the optimum parameters of radioisotope relay instruments

  3. Industrial applications of radioisotope techniques in Poland

    International Nuclear Information System (INIS)

    Michalik, J.St.

    1985-01-01

    A general review of applications of radioisotope techniques in the Polish industry for about 25 years is given. The radiotracer methods used in metallurgy, hydrometallurgy, glass industry, oil and petroleum industries, in material testing and in other industries are described. Neutron activation analysis methods as well as nuclear gauges for industry (thickness meters, density meters, conveyer belt weigher, acid concentration meters and others) are also presented. The economic advantages of industrial applications of radioisotope techniques are described too. 42 refs., 43 figs., 11 tabs. (author)

  4. Radioisotopic control and automation of food mills

    International Nuclear Information System (INIS)

    Pertsovskij, E.S.; Sakharov, Eh.V.; Dolinin, V.A.

    1980-01-01

    Domestic and foreign experience in application of radioisotope devices to process control in fool industry, is described. The diagrams of devices to block and account the production in systems of process monitoring and control are considered. The methods of determining chemical composition of substances are discussed, as sell as the devices used for those purposes and based on recording β-and γ-radiation absorption by substance. The methods for determining dust and smoke content in premises using radioisotope devices. Level indicators, moisture gages and densitimeters usedf ctol level humidity, density and concentration of food products in the process of production are described [ru

  5. Thyroiditis: Radioisotope Scan Findings and Clinical Significance

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Chae; Han, Duck Sup; Park, Jung Suck; Kim, Se Jong; Park, Byung Lan; Kim, Byoung Geun [Kwangju Christian Hospital, Kwangju (Korea, Republic of)

    1991-07-15

    We analyzed Radioisotope scan findings of 46 patients of thyroiditis which were proven pathologically at K.C.H. The results were as follows 1) 45 patients were female, one was male and average age of patients was 37 years old. 2) The lesion site was predominant in both lobe (67%) Hashimoto's thyroiditis showed enlarged thyroid (85%) with cold nodule (20%), diffuse decreased activity (10%), while subacute thyroiditis was presented absent activity (53%), poor visualization (20%) or cold nodule (7%). 4) Radioisotope scan was valuable in evaluating function of thyroid gland and detection of lesion but there was a limit of pathological nature.

  6. Clinical evaluation of radioisotope examination in oncology

    Energy Technology Data Exchange (ETDEWEB)

    Yasukochi, H [National Konodai Hospital (Japan)

    1979-07-01

    Although many approaches are tried for the diagnoses of malignant tumor, radiological examinations act surely main parts. Among the radiological examinations, radioisotope techniques are not well evaluated instead of their usefulness in this field. The reason may depend on the complexity and difficulty in legal limitations, however, the lack of knowledge in this field is also a main reason. In this paper, the present status of the evaluation of radioisotope techniques is discussed in selected region of the body and some characteristic cases are demonstrated.

  7. Validation of Plutonium Radioisotopes Analysis Using Alpha Spectrometry

    International Nuclear Information System (INIS)

    Noor Fadzilah Yusof; Jalal Sharib; Mohd Tarmizi Ishak; Zulkifli Daud; Abdul Kadir Ishak

    2016-01-01

    This paper presents the validation of an established method used to detect plutonium (Pu) radioisotopes in marine environment samples. The separation method consists of sample digestion, anion exchange, purification, electroplating and counting by an alpha spectrometry. Applying the method on standard reference materials from marine environment, the results are validated using seven parameters, namely specificity, linearity, bias or accuracy, detection limit, precision/ repeatability, reproducibility/ ruggedness and robustness in accordance with International Organization for Standardization (ISO) guidelines. The findings were that the results obtained were in a good agreement and satisfactory compared to the provided readings from certificate of reference materials. (author)

  8. Stirling Radioisotope Power System as an Alternative for NASAs Deep Space Missions

    Science.gov (United States)

    Shaltens, R. K.; Mason, L. S.; Schreiber, J. G.

    2001-01-01

    The NASA Glenn Research Center (GRC) and the Department of Energy (DOE) are developing a free-piston Stirling convertor for a Stirling Radioisotope Power System (SRPS) to provide on-board electric power for future NASA deep space missions. The SRPS currently being developed provides about 100 watts and reduces the amount of radioisotope fuel by a factor of four over conventional Radioisotope Thermoelectric Generators (RTG). The present SRPS design has a specific power of approximately 4 W/kg which is comparable to an RTG. GRC estimates for advanced versions of the SRPS with improved heat source integration, lightweight Stirling convertors, composite radiators, and chip-packaged controllers improves the specific mass to about 8 W/kg. Additional information is contained in the original extended abstract.

  9. Establishment study of the in vivo imaging analysis with small animal imaging modalities (micro-PET and micro-SPECT/CT) for bio-drug development

    International Nuclear Information System (INIS)

    Jang, Beomsu; Park, Sanghyeon; Park, Jeonghoon; Jo, Sungkee; Jung, Uhee; Kim, Seolwha; Lee, Yunjong; Choi, Daeseong

    2011-01-01

    In this study, we established the image acquisition and analysis procedures of micro-PET, SPECT/CT using the experimental animal (mouse) for the development of imaging assessment method for the bio-drug. We examined the micro-SPECT/CT, PET imaging study using the Siemens Inveon micro-multimodality system (SPECT/CT) and micro-PET with 99m Tc-MDP, DMSA, and 18 F-FDG. SPECT imaging studies using 3 types of pinhole collimators. 5-MWB collimator was used for SPECT image study. To study whole-body distribution, 99m Tc-MDP SPECT image study was performed. We obtained the fine distribution image. And the CT images was obtained to provide the anatomical information. And then these two types images are fused. To study specific organ uptake, we examined 99 mTc-DMSA SPECT/CT imaging study. We also performed the PET image study using U87MG tumor bearing mice and 18 F-FDG. The overnight fasting, warming and anesthesia with 2% isoflurane pretreatment enhance the tumor image through reducing the background uptake including brown fat, harderian gland and skeletal muscles. Also we got the governmental approval for use of x-ray generator for CT and radioisotopes as sealed and open source. We prepared the draft of process procedure for the experimental animal imaging facility. These research results can be utilized as a basic image study protocols and data for the image assessment of drugs including biological drug

  10. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1982

    International Nuclear Information System (INIS)

    Richards, M.P.

    1983-08-01

    The radioisotope production and distribution activities by facilities at Argonne National Laboratory, Pacific Northwest Laboratory, Brookhaven National Laboratory, Hanford Engineering Development Laboratory, Idaho Operations Office, Los Alamos Scientific Laboratory, Oak Ridge National Laboratory, Savannah River Laboratory, and UNC Nuclear Industries, Inc. are listed. The information is divided into five sections: isotope suppliers, facility, contacts, and isotopes or services supplied; alphabetical list of customers, and isotopes purchased; alphabetical list of isotopes cross-referenced to customs numbers; geographical location of radioisotope customers; and radioisotope sales and transfers-FY 1982

  11. Use of radioisotopes and nuclear methods in metallurgy

    International Nuclear Information System (INIS)

    Trehber, K.

    1976-01-01

    Some kinds of using radioisotope methods and instruments for regulation and control of metallurgical processes are reviewed. Computized data processing is described as well. The efficiency of industrial application of radioisotopes is remarked

  12. Calculation correlations for radioisotope level gages with relay tracing systems

    International Nuclear Information System (INIS)

    Krejndlin, I.I.; Pakhunkov, Yu.I.

    1978-01-01

    The interrelationship was examined between the operational and instrumental parameters of radioisotope tracking level indicators. The relationships were obtained permitting to check the reliability of the tracking regime, and also of the equilibrium state of the radioisotope tracking level indicator

  13. Radioisotopes present in building materials of workplaces

    Science.gov (United States)

    Del Claro, F.; Paschuk, S. A.; Corrêa, J. N.; Denyak, V.; Kappke, J.; Perna, A. F. N.; Martins, M. R.; Santos, T. O.; Rocha, Z.; Schelin, H. R.

    2017-11-01

    The isotope 222Rn is responsible for approximately half of the effective annual dose received by the world population. The decay products of 222Rn interacting with the cells of biological tissue of lungs have very high probability to induce cancer. The present survey was focused in the evaluation of activity concentration of 222Rn and other radioisotopes related to the building materials at workplaces at Curitiba - Paraná State. For this purpose, the instant radon detector AlphaGUARD (Saphymo GmbH) was used to measure the average concentrations of 222Rn in building materials, which were also submitted to gamma spectrometry analysis for qualitative and quantitative evaluation of the radionuclides present in samples of sand, mortar, blue crushed stone (Gneissic rock), red crushed stone (Granite), concrete and red bricks. The main radionuclides evaluated by gamma spectrometry in building material samples were 238U/226Ra, 232Th and 40K. These measurements were performed at the Laboratory of Applied Nuclear Physics of the Federal University of Technology - Paraná in collaboration with the Center of Nuclear Technology Development (CDTN - CNEN). The results of the survey present the concentration values of 222Rn related to construction materials in a range from 427±40.52 Bq/m³ to 2053±90.06 Bq/m³. The results of gamma spectroscopy analysis show that specific activity values for the mentioned isotopes are similar to the results indicated by the literature. Nevertheless, the present survey is showing the need of further studies and indicates that building materials can contribute significantly to indoor concentration of 222Rn.

  14. Regulations concerning the radionuclides uses in France; Reglementation de l'utilisation des radioisotopes en France

    Energy Technology Data Exchange (ETDEWEB)

    Vergne, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Bugnard, L. [Institut national d' Hygiene (France)

    1955-07-01

    The progress in the uses of radioisotopes has been conditioned by increasing the number of trained workers and researchers and developing theoretical teaching in universities since 1950 in France as well as developing a national control of the distribution and uses of radioisotopes. With the large diffusion and development of radioisotopes uses and applications, new rules and regulations came to control the importation, exportation, transport and utilization of radioisotopes. In the first part, it described the different French laws since 1934 and their successive modifications which ruled on the production, manipulation and utilization of radioisotopes. An inter-ministerial committee was created in 1952 to advise and inform of all the questions related to the preparation, importation, exportation, possession and distribution of radioisotopes. The transport regulations are in constant evolution and has got to meet with international recommendations. It distinguished three different type of transport: road, river and railway transport, postal transport and finally air transport. All the different transports have their specific packaging, maximum transportable quantity, maximum material intensity and labelling requirements. The regulations about customs duties are specified as well as the administrative formalities for non natural radioisotopes importation. Since 1950, diseases caused by irradiation to natural or artificial radioactive materials are recognised as professional diseases and a table of the actual regulations is presented. (M.P.)

  15. {sup 18}F-FDG PET and PET/CT in Burkitt's lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Karantanis, Dimitrios, E-mail: dkarantanis@nuclmed.ne [Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN (United States); Durski, Jolanta M.; Lowe, Val J.; Nathan, Mark A.; Mullan, Brian P. [Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN (United States); Georgiou, Evangelos [Medical Physics Department, Medical School, University of Athens (Greece); Johnston, Patrick B. [Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN (United States); Wiseman, Gregory A. [Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN (United States)

    2010-07-15

    Objective: To explore the value of {sup 18}F fluorodeoxy-glucose (FDG) positron emission tomography (PET) in Burkitt's lymphoma. Methods: All Burkitt's lymphoma patients referred for FDG PET or FDG PET/computed tomography (CT) exams at our institution from June 2003 to June 2006 were included. Selected patients were followed and clinical information was reviewed retrospectively. Results from FDG PET-PET/CT, as blindly reviewed by a consensus of two experienced readers, were compared with the status of the disease as determined by other laboratory, clinical and imaging exams and clinical follow-up. FDG PET-PET/CT results were classified as true positive or negative and false positive or negative. The degree of FDG uptake in the positive lesions was semiquantified as maximum standard uptake value (SUVmax). Results: Fifty-seven FDG PET-PET/CT exams were done in 15 patients. Seven exams were done for initial staging, 8 during and 14 after the completion of therapy, and 28 for disease surveillance. For nodal disease FDG PET-PET/CT was true positive in 8, true negative in 47 and false positive in 2 exams (sensitivity 100%, specificity 96%). For extranodal disease FDG PET-PET/CT was true positive in 6, true negative in 48 and false positive in 3 exams (sensitivity 100%, specificity 94%). The mean SUVmax for the positive nodal lesions was 15.7 (range 6.9-21.7, median 18.5) and for extranodal lesions was 14.2 (range 6.2-24.3, median 12.4). Conclusions: FDG PET-PET/CT is sensitive for the detection of viable disease in Burkitt's lymphoma. Affected areas demonstrated high degree of uptake that was reversible upon successful implementation of treatment.

  16. 18F-FDG PET and PET/CT in Burkitt's lymphoma

    International Nuclear Information System (INIS)

    Karantanis, Dimitrios; Durski, Jolanta M.; Lowe, Val J.; Nathan, Mark A.; Mullan, Brian P.; Georgiou, Evangelos; Johnston, Patrick B.; Wiseman, Gregory A.

    2010-01-01

    Objective: To explore the value of 18 F fluorodeoxy-glucose (FDG) positron emission tomography (PET) in Burkitt's lymphoma. Methods: All Burkitt's lymphoma patients referred for FDG PET or FDG PET/computed tomography (CT) exams at our institution from June 2003 to June 2006 were included. Selected patients were followed and clinical information was reviewed retrospectively. Results from FDG PET-PET/CT, as blindly reviewed by a consensus of two experienced readers, were compared with the status of the disease as determined by other laboratory, clinical and imaging exams and clinical follow-up. FDG PET-PET/CT results were classified as true positive or negative and false positive or negative. The degree of FDG uptake in the positive lesions was semiquantified as maximum standard uptake value (SUVmax). Results: Fifty-seven FDG PET-PET/CT exams were done in 15 patients. Seven exams were done for initial staging, 8 during and 14 after the completion of therapy, and 28 for disease surveillance. For nodal disease FDG PET-PET/CT was true positive in 8, true negative in 47 and false positive in 2 exams (sensitivity 100%, specificity 96%). For extranodal disease FDG PET-PET/CT was true positive in 6, true negative in 48 and false positive in 3 exams (sensitivity 100%, specificity 94%). The mean SUVmax for the positive nodal lesions was 15.7 (range 6.9-21.7, median 18.5) and for extranodal lesions was 14.2 (range 6.2-24.3, median 12.4). Conclusions: FDG PET-PET/CT is sensitive for the detection of viable disease in Burkitt's lymphoma. Affected areas demonstrated high degree of uptake that was reversible upon successful implementation of treatment.

  17. Fast and simple preparation of 68Ga-citrate for routine clinical PET

    DEFF Research Database (Denmark)

    Nielsen, Karin M; Kaufmann, Jens; Mewis, Dennis

    2013-01-01

    The imaging of infectious and inflammatory diseases using gallium-67 (⁶⁷Ga) citrate scintigraphy has been a well-established diagnostic tool for decades. In recent times, interest has focused on PET using the short-lived positron emitting radioisotope ⁶⁸Ga. ⁶⁸Ga is not only more readily available...

  18. Fast and simple one-step preparation of Ga-68 citrate for routine clinical PET

    DEFF Research Database (Denmark)

    Jensen, Svend B.; Nielsen, Karin M.; Mewis, Dennis

    2013-01-01

    The imaging of infectious and inflammatory diseases using gallium-67 (Ga-67) citrate scintigraphy has been a well-established diagnostic tool for decades. In recent times, interest has focused on PET using the short-lived positron emitting radioisotope Ga-68. Ga-68 is not only more readily...

  19. Structure and manual of radioisotope-production data base, ISOP

    International Nuclear Information System (INIS)

    Hata, Kentaro; Terunuma, Kusuo

    1994-02-01

    We planned on collecting the information of radioisotope production which was obtained from research works and tasks at the Department of Radioisotopes in JAERI, and constructed a proto-type data base ISOP after discussion of the kinds and properties of the information available for radioisotope production. In this report the structure and the manual of ISOP are described. (author)

  20. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1979

    International Nuclear Information System (INIS)

    Burlison, J.S.

    1980-06-01

    The fifteenth edition of the radioisotope customer list was prepared at the request of the Division of Financial Services, Office of the Assistant Secretary for Environment, Department of Energy (DOE). This document lists DOE's radioisotope production and distribution activities by its facilities at Argonne National Laboratory; Pacific Northwest Laboratory; Brookhaven National Laboratory; Hanford Engineering Development Laboratory; Idaho Operations Office; Los Alamos Scientific Laboratory; Mound Facility; Oak Ridge National Laboratory; Rocky Flats Area Office; Savannah River Laboratory; and UNC Nuclear Industries, Inc. The information is divided into five sections: Isotope suppliers, facility, contracts and isotopes or services supplied; alphabetical list of customers, and isotopes purchased; alphabetical list of isotopes cross-referenced to customer numbers; geographical location of radioisotope customers; and radioisotope sales and transfers-FY 1979

  1. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1981

    International Nuclear Information System (INIS)

    Burlison, J.S.

    1982-09-01

    The seventeenth edition of the radioisotope customer list was prepared at the request of the Office of Health and Environmental Research, Office of Energy Research, Department of Energy (DOE). This document lists DOE's radioisotope production and distribution activities by its facilities at Argonne National Laboratory: Pacific Northwest Laboratory; Brookhaven National Laboratory; Hanford Engineering Development Laboratory; Idaho Operations Office; Los Alamos Scientific Laboratory; Mound Facility; Oak Ridge National Laboratory; Savannah River Laboratory; and UNC Nuclear Industries, Inc. The information is divided into five sections: (1) isotope suppliers, facility, contracts and isotopes or services supplied; (2) alphabetical list of customers, and isotopes purchased; (3) alphabetical list of isotopes cross-referenced to customer numbers; (4) geographical location of radioisotope customers; and (5) radioisotope sales and transfers-FY 1980

  2. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1980

    International Nuclear Information System (INIS)

    Burlison, J.S.

    1981-08-01

    The sixteenth edition of the radioisotope customer list was prepared at the request of the Office of Health and Environmental Research, Office of energy Research, Department of Energy (DOE). This document lists DOE's radioisotope production and distribution activities by its facilities at Argonne National Laboratory; Pacific Northwest Laboratory; Brookhaven National Laboraory; Hanford Engineering Development Laboratory; Idaho Operations Office; Los Alamos Scientific Laboratory; Mound Facility; Oak Ridge National Laboratory; Savannah River Laboratory; and UNC Nuclear Industries, Inc. The information is divided into five sections: (1) isotope suppliers, facility, contracts and isotopes or services supplied; (2) alphabetical list of customers, and isotopes purchased; (3) alphabetical list of isotopes cross-referenced to customer numbers; (4) geographical location of radioisotope customers; and (5) radioisotope sales and transfers-FY 1980

  3. Pseudo-random generator to allow to an electronic pulse simulator the ability to emulate radioisotopes spectra

    International Nuclear Information System (INIS)

    Lucianna F A; Carrillo M A; Mangussi M J

    2012-01-01

    The present work describes the development of a pseudo-random system to provide to a simulator pulse of radiation detectors the ability to emit pulses patterns similar to those recorded when measuring actual radioisotope. The idea is that the system can emulate characteristic spectral distributions of known radioisotopes, as well as creating individual spectra for specific purposes. This design is based on an improvement in terms of software from earlier development that only supplied predefined amplitude pulses at constant intervals (author)

  4. Healthy Pets and People

    Science.gov (United States)

    ... prevent the spread of germs between pets and people. Keep pets and their supplies out of the kitchen, and ... a local wildlife rehabilitation facility. More Information Healthy Pets Healthy People Clean Hands Save Lives! Stay Healthy at Animal ...

  5. The industrial application of radioisotopes in Australia

    International Nuclear Information System (INIS)

    Easey, J.F.

    1987-01-01

    Over the past 10 years, the Australian Atomic Energy Commission has conducted a wide-ranging program of radioisotope applications to solve industrial problems of local, regional or national importance. Most of the investigations have been concerned with the behaviour of large complex systems. Broadly, the work covers such economically important fields as flow studies, environmental studies and coastal engineering studies. (author)

  6. How to find out in radioisotope methodology

    International Nuclear Information System (INIS)

    Evers, C.

    1976-01-01

    The subject is dealt with in sections entitled: tracing books by topic; radioisotope methodology cross reference structure; finding a review; journals and how to trace journal articles; abstract; theses and dissertations; research and development reports; critical reviews and information summaries; data books; dictionaries and encyclopedias; guides to the literature; whom to contact; expert advice, research in progress, institutions. (U.K.)

  7. Fuel selection for radioisotope thermoelectric generators

    International Nuclear Information System (INIS)

    Menezes, A.

    1988-06-01

    The availability of Radioisotope Thermoeletric Generator fuels is evaluated based on the amount of fuel discharged from selected power reactors. In general, the best alternatives are either to use Plutonium-238 produced by irradiation of Neptunium-237 generated in typical thermal reactors or to use Curium-244 directly separated from the discharged fuels of fast or thermal reactors. (author) [pt

  8. Radioisotopes as Political Instruments, 1946–1953

    Science.gov (United States)

    Creager, Angela N. H.

    2009-01-01

    The development of nuclear “piles,” soon called reactors, in the Manhattan Project provided a new technology for manufacturing radioactive isotopes. Radioisotopes, unstable variants of chemical elements that give off detectable radiation upon decay, were available in small amounts for use in research and therapy before World War II. In 1946, the U.S. government began utilizing one of its first reactors, dubbed X-10 at Oak Ridge, as a production facility for radioisotopes available for purchase to civilian institutions. This program of the U.S. Atomic Energy Commission was meant to exemplify the peacetime dividends of atomic energy. The numerous requests from scientists outside the United States, however, sparked a political debate about whether the Commission should or even could export radioisotopes. This controversy manifested the tension in U.S. politics between scientific internationalism as a tool of diplomacy, associated with the aims of the Marshall Plan, and the desire to safeguard the country’s atomic monopoly at all costs, linked to American anti-Communism. This essay examines the various ways in which radioisotopes were used as political instruments—both by the U.S. federal government in world affairs, and by critics of the civilian control of atomic energy—in the early Cold War. PMID:20725612

  9. Radioisotopes as Political Instruments, 1946-1953.

    Science.gov (United States)

    Creager, Angela N H

    2009-01-01

    The development of nuclear "piles," soon called reactors, in the Manhattan Project provided a new technology for manufacturing radioactive isotopes. Radioisotopes, unstable variants of chemical elements that give off detectable radiation upon decay, were available in small amounts for use in research and therapy before World War II. In 1946, the U.S. government began utilizing one of its first reactors, dubbed X-10 at Oak Ridge, as a production facility for radioisotopes available for purchase to civilian institutions. This program of the U.S. Atomic Energy Commission was meant to exemplify the peacetime dividends of atomic energy. The numerous requests from scientists outside the United States, however, sparked a political debate about whether the Commission should or even could export radioisotopes. This controversy manifested the tension in U.S. politics between scientific internationalism as a tool of diplomacy, associated with the aims of the Marshall Plan, and the desire to safeguard the country's atomic monopoly at all costs, linked to American anti-Communism. This essay examines the various ways in which radioisotopes were used as political instruments-both by the U.S. federal government in world affairs, and by critics of the civilian control of atomic energy-in the early Cold War.

  10. Radioisotopes - their applications in industrial radiography

    International Nuclear Information System (INIS)

    Rao, H.R.S.

    1977-01-01

    The nature of radioisotopes and their industrial applications with special reference to industrial radiography are outlined. The various aspects of industrial radiography such as source size, source containers, films, density of radiography, radiographic quality and applications are discussed in brief. (M.G.B.)

  11. Radioisotopes and food preservation against insects

    International Nuclear Information System (INIS)

    Hachem Ahmad, M.S.

    1998-01-01

    The book describes how to preserve food from harmful insects by using radioisotopes. It focusses on the impact of ionized radiation on the different stages of insect growth and on its metabolism and immunity. It also discusses the relationship between radiation doses and insect reproduction. It explains the various methods to detect the irradiated foods

  12. Radioisotope techniques used in breast cancer

    International Nuclear Information System (INIS)

    Au-Yong Ting Kun

    2001-01-01

    Breast cancer is one of the commonest cancer in women. Treatment and prognosis of breast cancer depend very much on accurate diagnosis, staging and follow-up of patients. Recently, there are several radioisotope techniques developed and have great impact on management of breast cancer. These include scintimammography, sentinel lymph node detection and positron emission tomography. This article is to review these important techniques

  13. Radioisotope licence application: Fixed nuclear gauges

    International Nuclear Information System (INIS)

    1995-09-01

    This guide will assist you in completing and filing an application for a new licence or licence renewal for fixed nuclear gauges in accordance with the Atomic Energy Control Regulations and radioisotope licensing policies. It also provides some of the background information that you will require in order to safely use radioactive materials

  14. Application of artificial radioisotopes in hydrological studies

    International Nuclear Information System (INIS)

    Jacob, Noble; Shivanna, K.

    2009-01-01

    In this article, various applications of the artificial radioisotopes in surface water and groundwater investigations are briefly reviewed with a few recent case studies. They are found to be extremely useful in understanding the hydrological processes and obtaining pertinent parameters such as dilution factors, dispersion coefficients, rate of sediment transport in surface waters and recharge rate, velocity and flow direction in groundwater systems. (author)

  15. The control of radioisotopes in Canada

    International Nuclear Information System (INIS)

    Hamel, P.E.

    1980-01-01

    The Regulations applicable to the control of radioisotopes in Canada are reviewed. The administrative procedures are described, the definition of atomic radiation workers clarified and the means for inspections and compliance indicated. An outline is provided of the main revisions currently under consideration. (author) [fr

  16. List of ERDA radioisotope (customers with summary of radioisotope shipments FY 1975

    International Nuclear Information System (INIS)

    Simmons, J.L.; Gano, S.R.

    1976-01-01

    The twelfth edition of the ERDA radioisotope customer list has been prepared at the request of the Division of Biomedical and Environmental Research. The purpose of this document is to list the FY 1975 commercial radioisotope production and distribution activities of USERDA facilities at Argonne National Laboratory, Battelle, Pacific Northwest Laboratories, Brookhaven National Laboratory, United Nuclear Inc., Idaho Operations Office, Hanford Engineering Development Laboratory, Mound Laboratory, Oak Ridge National Laboratory, and Savannah River Plant

  17. List of ERDA radioisotope customers with summary of radioisotope shipments, FY 1976

    International Nuclear Information System (INIS)

    Simmons, J.L.

    1977-03-01

    The thirteenth edition of the ERDA radioisotope customer list has been prepared at the request of the Office of Program Coordination, Office of the Assistant Administrator. The purpose of the document is to list the FY 1976 commercial radioisotope production and distribution activities of ERDA facilities at Argonne National Laboratory, Battelle, Pacific Northwest Laboratories, Brookhaven National Laboratory, Hanford Engineering Development Laboratory, Idaho Operations Office, Los Alamos Scientific Laboratory, Mound Laboratory, Oak Ridge National Laboratory, Savannah River Laboratory, and United Nuclear Industries, Inc

  18. Status of NASA's Advanced Radioisotope Power Conversion Technology Research and Development

    Science.gov (United States)

    Wong, Wayne A.; Anderson, David J.; Tuttle, Karen L.; Tew, Roy C.

    2006-01-01

    NASA s Advanced Radioisotope Power Systems (RPS) development program is funding the advancement of next generation power conversion technologies that will enable future missions that have requirements that can not be met by either the ubiquitous photovoltaic systems or by current Radioisotope Power Systems (RPS). Requirements of advanced radioisotope power systems include high efficiency and high specific power (watts/kilogram) in order to meet mission requirements with less radioisotope fuel and lower mass. Other Advanced RPS development goals include long-life, reliability, and scalability so that these systems can meet requirements for a variety of future space applications including continual operation surface missions, outer-planetary missions, and solar probe. This paper provides an update on the Radioisotope Power Conversion Technology Project which awarded ten Phase I contracts for research and development of a variety of power conversion technologies consisting of Brayton, Stirling, thermoelectrics, and thermophotovoltaics. Three of the contracts continue during the current Phase II in the areas of thermoelectric and Stirling power conversion. The accomplishments to date of the contractors, project plans, and status will be summarized.

  19. PET studies in dementia

    International Nuclear Information System (INIS)

    Herholz, K.

    2003-01-01

    Measurement of local cerebral glucose metabolism (lCMRGlc) by positron emission tomography (PET) and 18 F-2-fluoro-2-deoxy-D-glucose (FDG) has become a standard technique during the past 20 years and is now available at many university hospitals in all highly developed countries. Many studies have documented a close relation between lCMRGlc and localized cognitive functions, such as language and visuoconstructive abilities. Alzheimer's disease (AD) is characterized by regional impairment of cerebral glucose metabolism in neocortical association areas (posterior cingulate, temporoparietal and frontal multimodal association cortex), whereas primary visual and sensorimotor cortex, basal ganglia, and cerebellum are relatively well preserved. In a multicenter study comprising 10 PET centers (Network for Efficiency and Standardization of Dementia Diagnosis, NEST-DD) that employed an automated voxel-based analysis of FDG PET images, the distinction between controls and AD patients was 93% sensitive and 93% specific, and even in very mild dementia (at Mini Mental Status Examination (MMSE) 24 or higher) sensitivity was still 84% at 93% specificity. Significantly abnormal metabolism in mild cognitive deficit (MCI) indicates a high risk to develop dementia within the next two years. Reduced neocortical glucose metabolism can probably be detected with FDG PET in AD on average one year before onset of subjective cognitive impairment. In addition to glucose metabolism, specific tracers for dopamine synthesis ( 18 F-F-DOPA) and for ( 11 C-MP4A) are of interest for differentiation among dementia subtypes. Cortical acetylcholine esterase activity (AChE) activity is significantly lower in patients with AD or with dementia with Lewy bodies (DLB) than in age-matched normal controls. In LBD there is also impairment of dopamine synthesis, similar to Parkinson disease. (author) 115 refs

  20. PET studies in dementia

    Energy Technology Data Exchange (ETDEWEB)

    Herholz, K. [Neurologische Universitaetsklinik and Max-Planck-Inst. fuer neurologische Forschung, Koeln (Germany)

    2003-04-01

    Measurement of local cerebral glucose metabolism (lCMRGlc) by positron emission tomography (PET) and {sup 18}F-2-fluoro-2-deoxy-D-glucose (FDG) has become a standard technique during the past 20 years and is now available at many university hospitals in all highly developed countries. Many studies have documented a close relation between lCMRGlc and localized cognitive functions, such as language and visuoconstructive abilities. Alzheimer's disease (AD) is characterized by regional impairment of cerebral glucose metabolism in neocortical association areas (posterior cingulate, temporoparietal and frontal multimodal association cortex), whereas primary visual and sensorimotor cortex, basal ganglia, and cerebellum are relatively well preserved. In a multicenter study comprising 10 PET centers (Network for Efficiency and Standardization of Dementia Diagnosis, NEST-DD) that employed an automated voxel-based analysis of FDG PET images, the distinction between controls and AD patients was 93% sensitive and 93% specific, and even in very mild dementia (at Mini Mental Status Examination (MMSE) 24 or higher) sensitivity was still 84% at 93% specificity. Significantly abnormal metabolism in mild cognitive deficit (MCI) indicates a high risk to develop dementia within the next two years. Reduced neocortical glucose metabolism can probably be detected with FDG PET in AD on average one year before onset of subjective cognitive impairment. In addition to glucose metabolism, specific tracers for dopamine synthesis ({sup 18}F-F-DOPA) and for ({sup 11}C-MP4A) are of interest for differentiation among dementia subtypes. Cortical acetylcholine esterase activity (AChE) activity is significantly lower in patients with AD or with dementia with Lewy bodies (DLB) than in age-matched normal controls. In LBD there is also impairment of dopamine synthesis, similar to Parkinson disease. (author) 115 refs.

  1. Contribution of radioisotopic techniques to identify sentinel lymph-nodes (SLN) in breast cancer

    International Nuclear Information System (INIS)

    Zarlenga, Ana C.; Katz, Lidia; Armesto, Amparo; Noblia, Cristina; Gorostidi, Susana; Perez, Juan; Parma, Patricia

    2009-01-01

    The SLN (one or several) is the first to receive lymph from a tumor. When a cancer cell comes off the tumor and circulates along the outgoing lymph, it meets a barrier, the SLN that intercepts and destroys it. If not, the cancer cell can stay and reproduce in the SLN making a metastasis which can affect other nodes in the same way. It has been shown that if the original tumor is small there is little chance that the SLN could be invaded and therefore little chance of dissemination to other lymph-nodes. Nowadays due to early detection, breast tumors are smaller than one cm, therefore with such size there is little chance of axillary lymph-nodes being affected. If it is confirmed by histological study that the SLN is free of metastasis, it is not necessary to perform a axillary emptying. This identification of SLNs has been achieved because of the advances of Radioisotopic Techniques, which has been carried out in our Hospital since 1997. We have been adapting this technique to the national supply of equipment and radio compounds always under a reliable and secure way. The aim of this presentation is to highlight the radioisotopic identification of SLNs in clinical investigation in 'Angel H. Roffo Institute', and its daily practice compare with Positron Emission Tomography (PET). By combining Radioisotopic Lymphography, Lymphochromography and intra surgical detection of the SN with Gamma Probe, we have obtained a true negative value of 95% of the SN, with 5% false negative. Due to this method we have included SN study in daily practice breast tumor patients with tumor up to 5 cm of diameter. Comparing this methods result (5% false negative), with the PET results, using 18 F-FDG, that has 33% false negatives, we conclude that a negative result can not replace this method of SN detection. (author)

  2. Study of solid target preparation for developing I-124, Pd-103, Cu-64 radioisotopes based cyclotron

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Hong; Park, Hyun; Lee, Ji Sub; Lee, Dong Hoon; Chun, Kwon Soo [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Choi, Hee Dong [Seoul National Univ., Seoul (Korea, Republic of)

    2005-07-01

    The decay characteristics of I-124, Pd-103 and Cu-64 radioisotopes produced by cyclotron have considered useful agents for diagnostic imaging or therapy. Numbers of radioisotopes used in medical applications or promised for development are produced with solid targets. The aims of developing solid targets are to obtain large quantities of radionuclides from accelerators. The scope of the study is to develop optimized target system and chemical procedures of these radioisotopes. In order to increase the availability of the radionuclides, the investigation for the design of the solid target and different procedures yielding efficient production of high specific activity will be carrying. In this work, we will present the issue of the primary target design concept.

  3. Novel Radioisotope Applications in Industry Promoted by the IAEA

    International Nuclear Information System (INIS)

    Thereska, J.

    2001-01-01

    Presently, there is a lively activity in further development and use of radioisotope technology. Novel radioisotope applications in industry are promoted by the IAEA. Radioisotope technology is contributing significantly to improving and optimising process performance bringing an annual economic benefit to world-wide industry of several billion US$. Probably, an average benefit to cost ratio of 40:1 is reasonably representative of radioisotope applications in industry. There are few short-term investments, which will give a return of this magnitude. The cost effectiveness of radioisotope applications should be widely promulgated to encourage industrialists to take full advantage of the technology. (author)

  4. Antibody-radioisotope conjugates for tumor localization and treatment

    International Nuclear Information System (INIS)

    Larson, S.M.; Carrasquillo, J.A.

    1985-01-01

    In principle, anti-tumor antibodies can be used to carry radioactivity to tumors for in-vivo diagnosis and treatment of cancer. First, for diagnostic purposes, an antibody that targets a specific antigen (for example, the p97 antigen of human melanoma tumor), is labeled with a tracer amount of radioactivity. When this antibody-radioisotope conjugate is injected into the blood stream, the antibody carries the radioactivity throughout the body and in time, percolates through all the tissues of the body. Because the tumor has specific antigens to which the antibody can bind, the antibody conjugate progressively accumulates in the tumor. Using conventional nuclear medicine imaging equipment, the body of the patient is scanned for radioactivity content, and a map of the distribution of the radioactivity is displayed on photographic film. The tumor shows up as a dense area of radio-activity. These same antibody-radioisotope conjugates may be used for therapy of tumors, except that in this case large amounts of radioactivity are loaded on the antibody. After localization of the conjugate there is sufficient radiation deposited in the tumor of radiotherapy. The success of this approach in the clinic is determined in large measure by the concentration gradient that can be achieved between tissue antibody conjugate in tumor versus normal tissue

  5. Rare Case of Intratracheal Metastasis Detected on 68Ga-Prostate-Specific Membrane Antigen PET/CT Scan in a Case of Thyroglobulin Elevated Negative Iodine Scan Syndrome.

    Science.gov (United States)

    Sasikumar, Arun; Joy, Ajith; Pillai, M R A; Oommen, Karuna Elza; Jayakumar, R

    2018-04-01

    A 64-year-old woman underwent completion thyroidectomy with upper tracheal ring resection and right-sided neck dissection for papillary carcinoma of the thyroid infiltrating the trachea and was given I radioiodine treatment. Three years later, she presented with hemoptysis. On evaluation, she had increased serum thyroglobulin and negative iodine scan (TENIS). F-FDG PET/CT scan did not identify any site of disease. One year later, Ga-PSMA scan done revealed a moderate focal tracer-avid intratracheal soft tissue; biopsy revealed it to be metastatic papillary carcinoma of the thyroid. This case kindles the possibility of using Ga-PSMA PET/CT to reveal occult disease in cases of TENIS.

  6. PET-MRI and multimodal cancer imaging

    International Nuclear Information System (INIS)

    Wang Taisong; Zhao Jinhua; Song Jianhua

    2011-01-01

    Multimodality imaging, specifically PET-CT, brought a new perspective into the fields of clinical imaging. Clinical cases have shown that PET-CT has great value in clinical diagnosis and experimental research. But PET-CT still bears some limitations. A major drawback is that CT provides only limited soft tissue contrast and exposes the patient to a significant radiation dose. MRI overcome these limitations, it has excellent soft tissue contrast, high temporal and spatial resolution and no radiation damage. Additionally, since MRI provides also functional information, PET-MRI will show a new direction of multimodality imaging in the future. (authors)

  7. Identification of time-to-peak on dynamic 18F-FET-PET as a prognostic marker specifically in IDH1/2 mutant diffuse astrocytoma.

    Science.gov (United States)

    Suchorska, Bogdana; Giese, Armin; Biczok, Annamaria; Unterrainer, Marcus; Weller, Michael; Drexler, Mark; Bartenstein, Peter; Schüller, Ulrich; Tonn, Jörg-Christian; Albert, Nathalie L

    2018-01-22

    Stratification of glioma according to isocitrate dehydrogenase 1/2 (IDH1/2) mutation and 1p/19q codeletion status has gained major importance in the new World Health Organization (WHO) classification. Parameters derived from uptake dynamics of 18F-fluoro-ethyl-tyrosine PET (18F-FET-PET) such as minimal time-to-peak (TTPmin) allow discrimination between different prognostic glioma subgroups, too. The present study is aimed at exploring whether TTPmin analysis provides prognostic information beyond the WHO classification. Three hundred patients with newly diagnosed WHO 2007 grades II-IV gliomas with 18F-FET-PET imaging at diagnosis were grouped into 4 subgroups (IDH1/2 mut-1p/19q codel; IDH1/2 mut-1p/19q non-codel; IDH1/2 wildtype WHO grade II and III tumors; and glioblastoma). Clinical and imaging factors such as age, Karnofsky performance score, treatment, TTPmin, and maximal tumor-to-brain ratio (TBRmax) were analyzed with regard to progression-free and overall survival (PFS and OS) via univariate and multivariate regression analysis. PFS and OS were longest in the IDH1/2 mut-1p/19q codel subgroup, followed by IDH1/2 mut-1p/19q non-codel, IDH1/2 wildtype, and GBM (P 17.5 minutes (P PET-derived dynamic analysis defines prognostically distinct subgroups of IDH1/2 mutant-1p/19q non-codel gliomas which cannot be distinguished as yet by molecular marker analysis. © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  8. The Installation of a P.E.T. Pharmacy at Washington University

    International Nuclear Information System (INIS)

    Gaehle, G.; Schwarz, S.; Mueller, M.; Margenau, B.; Welch, M.J.

    2003-01-01

    Washington University has produced radioisotopes for medical application since the early 1960s. In order to serve seven PET scanners and to meet more stringent government regulations we have installed a new PET pharmacy based on our past years of experiences. The new pharmacy was installed at the site of the 3.7 MeV tandem cascade accelerator that was decommissioned in April of 2001. The pharmacy consists of a production lab, quality control lab, reagent preparation lab, shipping and storage area and an office. Security and safety was a main consideration in the design of this PET pharmacy

  9. Application of PET and PET/CT imaging for cancer screening

    International Nuclear Information System (INIS)

    Chen Yenkung; Hu Fenglan; Shen Yehyou; Liao, A.C.; Hung, T.Z.; Su, Chentau; Chen Liangkuang

    2004-01-01

    The aim of this study was to evaluate the potential application of 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) and PET/CT for cancer screening in asymptomatic individuals. Methods: The subjects consisted of 3631 physical check up examinees (1947 men, 1684 women; mean age ±SD, 52.1±8.2 y) with non-specific medical histories. Whole-body FDG PET (or PET/CT), ultrasound and tumor markers were performed on all patients. Focal hypermetabolic areas with intensities equal to or exceeding the level of FDG uptake in the brain and bladder were considered abnormal and interpreted as neoplasia. Follow-up periods were longer than one year. Results: Among the 3631 FDG PET (including 1687 PET/CT), ultrasound and tumor markers examinations, malignant tumors were discovered in 47 examinees (1.29%). PET findings were true-positive in 38 of the 47 cancers (80.9%). In addition, 32 of the 47 cancers were performed with the PET-CT scan. PET detected cancer lesions in 28 of the 32 examinees. However, the CT detected cancer lesions in only 15 of 32 examinees. Conclusion: The sensitivity of FDG PET in the detection of a wide variety of cancers is high. Most cancer can be detected with FDG PET in a resectable stage. CT of the PET/CT for localization and characteristics of the lesion shows an increased specificity of the PET scan. Using ultrasound and tumor markers may complement the PET scan in cancer screening for hepatic and urologic neoplasms. (authors)

  10. The study on the adaptation for regulation - the permission of a radioisotope

    Energy Technology Data Exchange (ETDEWEB)

    Park, Byoung Il; Choi, Won Seok; Jung, Yong Moon [Gallup Korea, Seoul (Korea, Republic of)

    2003-08-15

    The restriction -the permission of a radioisotope keeps satisfaction with almost parts for example, awareness, observance and so on. Moreover two concepts are considered fully -too strict about certain specific control rules and needed more discriminated application standards to each organization related to KINS, it's preserved and controlled properly even if the penalties are downsized.

  11. Dynamic Studies with Radioisotopes in Medicine. Proceedings of the Symposium on Dynamics Studies with Radioisotopes in Clinical Medicine and Research

    International Nuclear Information System (INIS)

    1971-01-01

    Observations on the temporal patterns of uptake, metabolism, clearance or excretion of administered radioactive materials form the basis of many important applications of radioisotopes in clinical medicine and research. Such applications include studies of organ function, of regional blood flow and of the turnover of various substances in the human body. Newly available radioisotopes, new instruments such as gamma came ras, new techniques and new methods of data analysis based on the use of analogue and digital computers are continually enlarging the scope of the applications. Progress in these matters was discussed at the Symposium on Dynamic Studies with Radioisotopes in Clinical Medicine and Research, organized by the lnternational Atomic Energy Agency and held in Rotterdam, The Netherlands, from 31 August to 4 September 1970. A total of 315 participants nominated by 39 countries and 4 international organizations attended, and the 70 papers presented cove r the theoretical aspects of dynamic studies, the development of techniques and instruments for such studies, and specific applications in studies of thyroid, renal, hepatic and splenic function, mineral metabolism, regional blood flow, and cardiac and pulmonary function. The proceedings include the full texts of all the papers presented together with the edited discussions. Invited review papers deal with the general aspects of the various main groups of applications covered. Many of the applications described have already reached the stage of routine use; others are still in the developmental stage. Of particular note in the latter connection are applications based on the quantitative analysis of scintillation camera data. The many papers presented on these topics and the ensuing discussions indicate the great interest now shown in this promising area of development. It is hoped that the proceedings will provide a valuable guide to the present status of the subject

  12. Developing simplified Regional Potential Evapotranspiration (PET ...

    African Journals Online (AJOL)

    Regional Potential Evapotranspiration (PET) estimation method was developed to estimate the potential evapotranspiration (reference evapotranspiration) over Abbay Basin as a function of basin maximum and minimum temperature, and modulated by site specific elevation data. The method is intended to estimate PET in ...

  13. Radioisotopes in Hydrology. Proceedings of a Symposium

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1963-08-15

    The increasing emphasis on the development of water resources poses problems which are of interest to all countries, both developing and advanced, where the demand for water is continuously rising. There is no doubt that greater efforts must be made to evaluate, control and develop water resources using all scientific means available and during recent years increasing attention has been directed to the supplementation of hydrological methods with radioisotope techniques. These techniques have already been applied to a number of problems and their potential usefulness demonstrated. Radioisotopes can be used for stream discharge measurements with an accuracy as good as that obtainable with conventional methods. They are also finding increasing application in the measurement of groundwater direction and velocity, the study of suspected interconnections between different sources of water, and the investigation of mixing processes in rivers and lakes. Radioisotope techniques have been used in different parts of the world for studying the transport of silt in rivers and harbours. Present research is directed towards making these investigations on a quantitative basis which, if successful, would be of great importance in the design of hydraulic structures. The method of finding out the age of groundwater by measuring its natural tritium content can be applied to the determination of the recharge rate of groundwater bodies, so enabling a more rational use of the groundwater reserves without fear of overexploitation. Current research is aimed at using carbon-14 for groundwater-dating to extend the age measurable by tritium. A Symposium on the use of radioisotopes in hydrology was organized by the Agency and held in March 1963 in Tokyo in co-operation with the Japanese Government, for whose material and other assistance and generous hospitality the Agency wishes to record its grateful appreciation. The Symposium was attended by about 100 participants from 14 countries and 5

  14. Pet Problems at Home: Pet Problems in the Community.

    Science.gov (United States)

    Soltow, Willow

    1984-01-01

    Discusses problems of pets in the community, examining the community's role related to disruptive pets and pet overpopulation. Also discusses pet problems at home, offering advice on selecting a pet, meeting a pet's needs, and disciplining pets. Includes a list of books, films/filmstrips, teaching materials, and various instructional strategies.…

  15. Diagnostic performance of FDG PET or PET/CT in prosthetic infection after arthroplasty: a meta-analysis

    International Nuclear Information System (INIS)

    Jin, H.; Yuan, L.; Li, C.; Kan, Y.; Yang, J.; Hao, R.

    2014-01-01

    The purpose of this study was to systematically review and perform a meta-analysis of published data regarding the diagnostic performance of positron emission tomography (PET) or PET/computed tomography (PET/CT) in prosthetic infection after arthroplasty. A comprehensive computer literature search of studies published through May 31, 2012 regarding PET or PET/CT in patients suspicious of prosthetic infection was performed in PubMed/MEDLINE, Embase and Scopus databases. Pooled sensitivity and specificity of PET or PET/CT in patients suspicious of prosthetic infection on a per prosthesis-based analysis were calculated. The area under the receiver-operating characteristic (ROC) curve was calculated to measure the accuracy of PET or PET/CT in patients with suspicious of prosthetic infection. Fourteen studies comprising 838 prosthesis with suspicious of prosthetic infection after arthroplasty were included in this meta-analysis. The pooled sensitivity of PET or PET/CT in detecting prosthetic infection was 86% (95% confidence interval [CI] 82-90%) on a per prosthesis-based analysis. The pooled specificity of PET or PET/CT in detecting prosthetic infection was 86% (95% CI 83-89%) on a per prosthesis-based analysis. The area under the ROC curve was 0.93 on a per prosthesis-based analysis. In patients suspicious of prosthetic infection, FDG PET or PET/CT demonstrated high sensitivity and specificity. FDG PET or PET/CT are accurate methods in this setting. Nevertheless, possible sources of false positive results and influcing factors should kept in mind.

  16. Diagnostic performance of FDG PET or PET/CT in prosthetic infection after arthroplasty: a meta-analysis.

    Science.gov (United States)

    Jin, H; Yuan, L; Li, C; Kan, Y; Hao, R; Yang, J

    2014-03-01

    The purpose of this study was to systematically review and perform a meta-analysis of published data regarding the diagnostic performance of positron emission tomography (PET) or PET/computed tomography (PET/CT) in prosthetic infection after arthroplasty. A comprehensive computer literature search of studies published through May 31, 2012 regarding PET or PET/CT in patients suspicious of prosthetic infection was performed in PubMed/MEDLINE, Embase and Scopus databases. Pooled sensitivity and specificity of PET or PET/CT in patients suspicious of prosthetic infection on a per prosthesis-based analysis were calculated. The area under the receiver-operating characteristic (ROC) curve was calculated to measure the accuracy of PET or PET/CT in patients with suspicious of prosthetic infection. Fourteen studies comprising 838 prosthesis with suspicious of prosthetic infection after arthroplasty were included in this meta-analysis. The pooled sensitivity of PET or PET/CT in detecting prosthetic infection was 86% (95% confidence interval [CI] 82-90%) on a per prosthesis-based analysis. The pooled specificity of PET or PET/CT in detecting prosthetic infection was 86% (95% CI 83-89%) on a per prosthesis-based analysis. The area under the ROC curve was 0.93 on a per prosthesis-based analysis. In patients suspicious of prosthetic infection, FDG PET or PET/CT demonstrated high sensitivity and specificity. FDG PET or PET/CT are accurate methods in this setting. Nevertheless, possible sources of false positive results and influcing factors should kept in mind.

  17. Radioisotopes for nuclear medicine: the future

    International Nuclear Information System (INIS)

    Carr, S.W.

    1998-01-01

    Full text: Nuclear medicine occupies an important niche in the spectrum of medical capability. Since its initial application on a routine basis over 30 years ago its importance has continued to grow. For example, it is expected that over 430,000 Australians will have a nuclear medicine procedure in 1998. Current procedures using nuclear medicine are mainly concerned with diagnosis of oncology, cardiology and neurology. The main radioisotope used in nuclear medicine is Tc 99m, which is produced by a 'so called' Mo-Tc 99m generator. Other isotopes which currently find routine use are Ga-67, Th-201 and I-131. The selective uptakes by particular organs or structures is facilitated by the use of 'cold kits' which after the chemistry of the radioisotope many of the recent advances have been concerned with increasing the selectivity for a particular organ structure. Several of these new agents show increased selectivity using antibody a peptide recognition units

  18. Application state of radioisotopes for medical use

    International Nuclear Information System (INIS)

    Nakajima, Tomoyoshi

    1979-01-01

    Application of unsealed radioisotopes as radiopharmaceuticals has been increasing year by year with the development of nuclear medicine. As for the radioisotopes for in vivo use which are internally administered and are detected by external scanning, the consumption of Tc-99 m drugs has increased rapidly. The sales of radiopharmaceuticals for in vivo use including 131 I, etc. amounted to four billion Yen in 1977. The consumption of the isotopes used in vitro for radioimmunoassay has made more rapid increase, and the sales of radiopharmaceuticals for in vitro use amounted to seven billion Yen in 1977. Radiopharmaceuticals have been used in 1,134 institutes all over Japan in 1978. 534 among them have applied radiopharmaceuticals to both in vivo and in vitro uses. Radioactive wastes have been increasing with the application of these unsealed radiopharmaceuticals, and their disposal method should be examined as there is a limit in their storage. (Kobatake, H.)

  19. Radioisotope thermionic converters for space applications

    International Nuclear Information System (INIS)

    Miskolczy, G.; Lieb, D.P.

    1990-01-01

    The recent history of radioisotope thermionics is reviewed, with emphasis on the U.S. programs, and the prospects for the future are assessed. In radioisotope thermionic converters the emitter heat is generated by the decay of a radioactive isotope. The thermionic converter emitter is mounted directly on a capsule containing the isotope. The rest of the capsule is generally insulated to reduce thermal loss. The development of isotope-fueled thermionic power systems for space application has been pursued since the late 1950's. The U.S. effort was concentrated on modular systems with alpha emitters as the isotope heat source. In the SNAP-13 program, the heat sources were Cerium isotopes and each module produced about 100 watts. The converters were planar diodes and the capsule was insulated with multi-foil insulation

  20. Medical radioisotope production - the Australian experience

    Energy Technology Data Exchange (ETDEWEB)

    Druce, M. [Australian Nuclear Science and Technology Organisation, Menai (Australia)

    1996-12-31

    The Australian government, through its instrumentality, the Australian Nuclear Science and Technology Organization (ANSTO), owns and operates a 10-MW Dido-class research reactor at Lucas Heights on the southern outskirts of Sydney. This is the only operating nuclear reactor in Australia. It was built in 1958 and has a maximum flux of 1 x 10{sup 14} n/cm{sup 2}{center_dot}s. ANSTO also jointly owns and operates a 30-MeV IBA negative ion cyclotron at Camperdown in central Sydney, which began operation in 1992. ANSTO is predominantly a research organization; however, radioisotopes are commercially produced through Australian Radioisotopes (ARI), an ANSTO business entity. Seventy-four people are employed by ARI, which is a vertically integrated organization, i.e., everything from target preparation to sale of products is undertaken.

  1. Cosmogenic radioisotopes in Gebel Kamil meteorite

    Science.gov (United States)

    Taricco, C.; Colombetti, P.; Bhandari, N.; Sinha, N.; Di Martino, M.; Vivaldo, G.

    2012-04-01

    Recently a small (45 m in diameter) and very young (radioisotope activity generated by cosmic rays in the meteoroids as they travel through the interplanetary space before falling on the Earth. From the 26Al activity measurement and its depth production profiles, we infer (i) that the radius of the meteoroid should be about 1 m, constraining to 30-40 ton the range of pre-atmospheric mass previously proposed and (ii) that the fragment should have been located deeply inside the meteoroid, at a depth > 0.7 m. The 44Ti activity is under the detection threshold of the apparatus; using the depth production profiles of this radioisotope and its half-life T1/2 = 59.2 y, we deduce an upper limit to the date of fall.

  2. Health problems of industrial applications of radioisotopes

    International Nuclear Information System (INIS)

    Kudrna, J.

    1976-01-01

    Radiation hygiene problems of industrial radioisotope applications are discussed. The observance of regulations is emphasised. Radiation protection is based on the principle of preventing early radiation damage and limiting late radiation damage to an acceptable level. The basic requirement is that the cumulated dose should be as low as possible, i.e., as low as is practically feasible in considering economic and social aspects. Notices 59/72 and 65/72, Collection of Laws, rule that if the limit of 3/10 of the maximum permissible dose is likely to be reached, control zones should be defined and marked at places of work where radioisotopes are handled. The characteristics of such a control zone are listed and the measures to be taken in case of accident are outlined. (B.S.)

  3. The future of medical radioisotope supply

    International Nuclear Information System (INIS)

    Peykov, Pavel

    2014-01-01

    The NEA and its High-level Group on the Security of Supply of Medical Radioisotopes (HLG-MR) have been actively examining the causes of supply shortages of the most widely used isotope in medical diagnostic imaging, technetium-99m ( 99m Tc), and its parent isotope molybdenum-99 ( 99 Mo). As a result of this examination, the HLG-MR has developed a policy approach that includes principles and supporting recommendations to address the causes of these supply shortages. Six policy principles were agreed by the HLG-MR in March 2011. These are implementation of full-cost recovery and outage reserve capacity (ORC) for 99 Mo production, a government role in the market, conversion to low-enriched uranium targets, international collaboration and periodic reviews of the supply chain. This article describes progress made in the implementation of the six principles and examines the projected global capacity for medical radioisotope production in the near future. (author)

  4. Development of radioisotope production in JAERI

    International Nuclear Information System (INIS)

    Yamabayashi, H.; Kato, H.; Umezawa, H.

    1992-01-01

    Since 1962, we have been developing methods and technology for producing a wide variety of processed radioisotopes and sealed radiation sources by using the JAERI's reactors, JRR-2, JRR-3, JRR-4 and JMTR, and providing the products to domestic users. At present, 29 nuclides and 31 products are on our list of processed radioisotopes. Some of those isotopes such as P-32, S-35, Cr-51 and short-lived nuclides are being produced regularly for distribution, but most of the rest are produced upon request. The radiation sources of Co-60 needles and Ir-192 pellets for industrial use and Gd-153 pellet, 7 kinds of Ir-192 and Au-198 grain for medical applications are produced and distributed routinely. (author)

  5. Mathematical models and accuracy of radioisotope gauges

    International Nuclear Information System (INIS)

    Urbanski, P.

    1989-01-01

    Mathematical expressions relating the variance and mean value of the intrinsic error with the parameters of one and multi-dimensional mathematical models of radioisotope gauges are given. Variance of the intrinsic error at the model's output is considered as a sum of the variances of the random error which is created in the first stages of the measuring chain and the random error of calibration procedure. The mean value of the intrinsic error (systematic error) appears always for nonlinear models. It was found that the optimal model of calibration procedure not always corresponds to the minimal value of the intrinsic error. The derived expressions are applied for the assessment of the mathematical models of some of the existing gauges (radioisotope belt weigher, XRF analyzer and coating thickness gauge). 7 refs., 5 figs., 1 tab. (author)

  6. Advanced Stirling Radioisotope Generator Life Certification Plan

    Science.gov (United States)

    Rusick, Jeffrey J.; Zampino, Edward J.

    2013-01-01

    An Advanced Stirling Radioisotope Generator (ASRG) power supply is being developed by the Department of Energy (DOE) in partnership with NASA for potential future deep space science missions. Unlike previous radioisotope power supplies for space exploration, such as the passive MMRTG used recently on the Mars Curiosity rover, the ASRG is an active dynamic power supply with moving Stirling engine mechanical components. Due to the long life requirement of 17 years and the dynamic nature of the Stirling engine, the ASRG project faced some unique challenges trying to establish full confidence that the power supply will function reliably over the mission life. These unique challenges resulted in the development of an overall life certification plan that emphasizes long-term Stirling engine test and inspection when analysis is not practical. The ASRG life certification plan developed is described.

  7. Brain PET scan

    Science.gov (United States)

    ... results on a PET scan. Blood sugar or insulin levels may affect the test results in people with diabetes . PET scans may be done along with a CT scan. This combination scan is called a PET/CT. Alternative Names Brain positron emission tomography; PET scan - brain References Chernecky ...

  8. Radioisotope sources for X-ray fluorescence analysis

    International Nuclear Information System (INIS)

    Leonowich, J.; Pandian, S.; Preiss, I.L.

    1977-01-01

    Problems involved in developing radioisotope sources and the characteristics of potentially useful radioisotopes for X-ray fluorescence analysis are presented. These include the following. The isotope must be evaluated for the physical and chemical forms available, purity, half-life, specific activity, toxicity, and cost. The radiation hazards of the source must be considered. The type and amount of radiation output of the source must be evaluated. The source construction must be planned. The source should also present an advance over those currently available in order to justify its development. Some of the isotopes, which are not in use but look very promising, are indicated, and their data are tabulated. A more or less ''perfect'' source within a given range of interest would exhibit the following characteristics. (1) Decay by an isometric transition with little or no internal conversion, (2) Have an intense gamma transition near the absorption edge of the element(s) of interest with no high energy gammas, (3) Have a sufficiently long half-life (in the order of years) for both economic and calibration reasons, (4) Have a sufficiently large cross-section for production in a reasonable amount of time. If there are competing reactions the interfering isotopes should be reasonably short-lived, or if not, be apt to be separated from the isotope chemically with a minimum of difficulty. (T.G.)

  9. Supercritical CO2 fluid radiochromatography system used to purify [11C]toluene for PET

    International Nuclear Information System (INIS)

    Muller, Ryan D.; Ferrieri, Richard A.; Gerasimov, Madina; Garza, Victor

    2002-01-01

    Abuse of inhalants in today's society has become such a widespread problem among today's adolescents that in many parts of the world their use exceeds that of many other illicit drugs or alcohol. Even so, little is known how such inhalants affect brain function to an extent that can lead to an abuse liability. While methodologies exist for radiolabeling certain inhalants of interest with short-lived positron emitting radioisotopes that would allow their investigation in human subjects using positron emission tomography (PET), the purification methodologies necessary to separate these volatile substances from the organic starting materials have not been developed. We've adapted supercritical fluid technology to this specific PET application by building a preparative-scale supercritical CO 2 fluid radiochromatograph, and applied it to the purification of [ 11 C]toluene. We've demonstrated that [ 11 C]toluene can be separated from the starting materials using a conventional C 18 HPLC column and pure supercritical CO 2 fluid as the mobile phase operating at 2000 psi and 40 deg. C. We've also shown that the purified radiotracer can be quantitatively captured on Tenax GR, a solid support material, as it exits the supercritical fluid stream, thus allowing for later desorption into a 1.5% cyclodextrin solution that is suitable for human injection, or into a breathing tube for direct inhalation

  10. Research and development for the application of radioisotope technology in SINR

    International Nuclear Information System (INIS)

    Zhang Jiahua

    1987-01-01

    A brief systematic account on the research and development for the application of radioisotope technology in Shanghai Institute of Nuclear Research (SINR) is presented. It comprehensively covers the following categories: 1. Radioisotopes produced by cyclotron; 2. Radioisotope-labelled compounds; 3. Radioisotope as source of energy converter; 4. Induced-radioisotope generation as a means for elemental analysis--the activation analysis; 5. Radioisotope equipped with electronic instrument for various application; and 6. Special usage of some radioisotopes

  11. Radioisotopes in the treatment of cancer

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1962-01-15

    Radiation treatment of malignant growths is not, of course, a novel procedure; both radium implants and X-rays generated at medium voltages (up to 250 kV) have been used all over the world for many years. However, large scale production of radioisotopes in atomic reactors has made radiotherapy available for the first time in less developed areas of the world. Moreover, the treatment has been simplified and, in many cases, made more effective

  12. Micro-battery Development using beta radioisotope

    International Nuclear Information System (INIS)

    Jung, H. K.; Cheong, Y. M.; Lee, N. H.; Choi, Y. S.; Joo, Y. S.; Lee, J. S.; Jeon, B. H.

    2007-06-01

    Nuclear battery which use the beta radiation sources emitting the low penetration radiation energy from radioisotope can be applied as the long term (more than 10 years) micro power source in MEMS and nano components. This report describes the basic concept and principles of nuclear micro-battery and its fabrication in space and military field. In particular direct conversion method is described by investigating the electron-hole generation and recombination in p-n junction of silicon betavoltaics with beta radiation

  13. Visualization of Radioisotope Detectability Over Time.

    Energy Technology Data Exchange (ETDEWEB)

    Huynh, Brady [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-02-01

    A radioactive isotope is an atom that has an unstable nucleus. The isotope can undergo radioactive decay, the process in which excessive nuclear energy is emitted from the nucleus in many different forms, such as gamma radiation, alpha particles, or beta particles. The important thing to note is that these emissions act as a signature for the isotope. Each radioisotope has a particular emission spectrum, emitting radiation at different energies and at different rates.

  14. Radiation protection at radioisotope processing facilities

    International Nuclear Information System (INIS)

    Hillier, L.R.; Decaire, R.

    2002-01-01

    MDS Inc. is Canada's largest diversified health and life sciences company and provides health care services and products to prevent, diagnose and treat disease. MDS Nordion Inc. is a subsidiary of MDS Inc. and is located in Ottawa, Ontario. It provides much of the world's supply of radioisotopes used in nuclear medicine primarily to diagnose, but also to treat disease. MDS Nordion is composed of three major production divisions at its Ottawa location and serves customers in three major markets. These are primarily: radioisotopes used in nuclear medicine (Nuclear Medicine Division), radiation processing for sterilization of medical equipment and supplies, and food (Ion Technologies Division), and teletherapy equipment used in cancer treatment (Therapy Systems Division). MDS Nordion supplies customers in over 100 countries, exporting more than 95 percent of its product processed in Canada. Every year, 15 to 20 million diagnostic imaging tests are carried out in hospitals around the world, using radioisotopes supplied by MDS Nordion. In addition, 150 to 200 million cubic feet (that's enough to cover an entire CFL field - including the end zones - stacked over half a kilometer high) of single use medical products are sterilized using MDS Nordion supplied equipment. MDS Nordion receives medical isotopes from AECL, Chalk River Laboratories and processes the material to purify and quantify the radioisotope product. Sealed sources, comprised of cobalt 60, are supplied from CANDU reactors. Production processes include ventilated shielded cells with remote manipulators, gloveboxes and fumehoods, to effectively control the safety of the workplace and the environment, and to prevent contamination of the products. The facilities are highly regulated by the Canadian Nuclear Safety Commission (CNSC) for safety and environmental protection. Products are also regulated by Health Canada and the US-Food and Drug Administration (FDA). (author)

  15. Utilization of radioisotopes in the agriculture

    International Nuclear Information System (INIS)

    Cerri, C.C.

    1987-01-01

    Some aspects of radioisotopes utilization in the agriculture, such as, the use of gamma radiation for genetic improvement of plants; the use of C 14 as tracer for comprehension of the vegetable physiology; the use of nitrogen and phosphorus isotopes in soil fertilization and plant nutrition; the use of radiation for inset sterelization and, measurement of the humidity and density of soils by neutron moderation and attenuation of gamma radiation, are presented. (M.C.K.) [pt

  16. Lethality of radioisotopes in early mouse embryos

    International Nuclear Information System (INIS)

    Macqueen, H.A.

    1979-01-01

    The development of pre-implantation mouse embryos was found to be prevented by exposure of the embryos to [ 35 S]methionine, but not to [ 3 H]methionine. Such embryos have also been shown to be highly sensitive to [ 3 H]thymidine. These observations are discussed with reference to the path lengths and energies of electrons emitted from the different radioisotopes. (author)

  17. The efficient importation and distribution of radioisotopes. Suggestions for the most economic importation of radioisotopes

    International Nuclear Information System (INIS)

    1963-01-01

    In the course of their work in many Member States, IAEA technical assistance experts have sometimes encountered difficulties in connection with the importation of radioactive isotopes. In some countries they have been consulted as to the possible improvement of import procedures. The purpose of this publication is to summarize the experience that has been gained in the hope that it may be useful both to scientists who wish to import radioisotopes for their work and to public officials who are concerned with the administrative and financial aspects of the problem. This question is of considerable importance because many countries have only limited resources of scientific man-power and foreign exchange and hence it is essential, if these resources are to be utilized fully, that efficient importing procedures be established. Furthermore, the success or failure of technical assistance activities may depend on whether radioisotopes needed for the project can be efficiently imported. Although the data summarized in this publication are based mainly on the experience of medical users of radioisotopes, they are equally applicable to their uses in other fields such as agriculture and hydrology. This publication covers the subject of importation and distribution of radioisotopes, and concludes with a brief section on the domestic production of short-lived radioisotopes in research reactors

  18. The efficient importation and distribution of radioisotopes. Suggestions for the most economic importation of radioisotopes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1963-08-01

    In the course of their work in many Member States, IAEA technical assistance experts have sometimes encountered difficulties in connection with the importation of radioactive isotopes. In some countries they have been consulted as to the possible improvement of import procedures. The purpose of this publication is to summarize the experience that has been gained in the hope that it may be useful both to scientists who wish to import radioisotopes for their work and to public officials who are concerned with the administrative and financial aspects of the problem. This question is of considerable importance because many countries have only limited resources of scientific man-power and foreign exchange and hence it is essential, if these resources are to be utilized fully, that efficient importing procedures be established. Furthermore, the success or failure of technical assistance activities may depend on whether radioisotopes needed for the project can be efficiently imported. Although the data summarized in this publication are based mainly on the experience of medical users of radioisotopes, they are equally applicable to their uses in other fields such as agriculture and hydrology. This publication covers the subject of importation and distribution of radioisotopes, and concludes with a brief section on the domestic production of short-lived radioisotopes in research reactors.

  19. Medical Radioisotope Scanning. Proceedings of a Seminar

    International Nuclear Information System (INIS)

    1959-01-01

    Of the many and varied uses of radioactive isotopes which have been developed in the past twenty years, their applications in medicine are among the most important. All over the world medical scientists have added radioisotopes to their armament in clinical research, diagnosis and radiotherapy. It is significant that the first scientific meeting organized by the International Atomic Energy Agency was devoted to a medical subject. It is not less significant as a symbol of the close co-operation which has been established between the Agency and other agencies of the United Nations family, that this first seminar was a joint undertaking with the World Health Organization. The determination of the distribution of a radioisotope within the human body - radioisotope scanning - is a technique which has made very rapid progress in the last few years in various medical centres throughout the world, and the necessity of providing an opportunity for an organized exchange of results, experience and opinions was clearly recognised. The value of such an exchange is demonstrated by the extensive discussions which took place and which are recorded in this volume, together with the original papers presented by those who have made such noteworthy contributions to progress in this field.

  20. Steps of radioisotope separation in Japan

    International Nuclear Information System (INIS)

    Nakane, Ryohei; Kitamoto, Asashi; Shimizu, Masami

    1998-03-01

    The Extraordinary Specialist Committee on Radioisotope Separation of the Atomic Energy Society of Japan has supported various actions on foundation, application and industrialization of the radioisotope separation over past 30 years to continue wide range of actions at a standpoint of specialist, since established in Showa 44 (1969). On June 1993 (Heisei 5), a memorial lecture meeting, as the 100th committee was held at the Institute of Physical and Chemical Research (RIKEN) of Wako-city in Saitama prefecture. At that time, a planning to publish an impressive memorial issue, to prepare orbits and episodes of actions, painful stories and fault examples of developments, and so forth like novels and to use for a future foundation, was determined. For its writing principle, it was settled to the base not to use mathematical equation as possible, to collect the essence like a tale, to collect actual and historical reports, and so on. And, for its writing content, it was determined to report on actual, painful and fault experiences in research and development, on data, topics and human relation, and on what to be remained for references. This book can be used not only for data collected on traces from fundamental to applied studies, technical development for industrialization, and so forth on radioisotope concentration, but also for a knowledge bag to give some hints to a man aiming to overcome a new problem. (G.K.)

  1. New Directions In Radioisotope Spectrum Identification

    International Nuclear Information System (INIS)

    Salaymeh, S.; Jeffcoat, R.

    2010-01-01

    Recent studies have found the performance of commercial handheld detectors with automatic RIID software to be less than acceptable. Previously, we have explored approaches rooted in speech processing such as cepstral features and information-theoretic measures. Scientific advances are often made when researchers identify mathematical or physical commonalities between different fields and are able to apply mature techniques or algorithms developed in one field to another field which shares some of the same challenges. The authors of this paper have identified similarities between the unsolved problems faced in gamma-spectroscopy for automated radioisotope identification and the challenges of the much larger body of research in speech processing. Our research has led to a probabilistic framework for describing and solving radioisotope identification problems. Many heuristic approaches to classification in current use, including for radioisotope classification, make implicit probabilistic assumptions which are not clear to the users and, if stated explicitly, might not be considered desirable. Our framework leads to a classification approach with demonstrable improvements using standard feature sets on proof-of-concept simulated and field-collected data.

  2. Present status of radioisotope production in JAERI

    International Nuclear Information System (INIS)

    Yamabayashi, Hisamichi

    1994-01-01

    Since 1962, the technology for producing a wide variety of processed radioisotopes and sealed radiation sources has been developed by using the reactors, JRR-1, JRR-2, JRR-3, JRR-4 and JMTR, and the products have been offered to domestic users. At present, 31 products of 29 nuclides are on the list of processed radioisotopes. Some of those isotopes such as P-32, S-35, Cr-51 and short lived nuclides are produced for regular distribution, but the rest are produced upon request. The radiation sources of Co-60 needles for industrial use, Ir-192 pellets for the nondestructive inspection of pipelines, Gd-153 pellets for the diagnosis of born mineral and seven kinds of brachy therapy Ir-192 and Au-198 grains are produced and distributed regularly. The organic compounds labeled with H-3 and C-14 are widely used. In fiscal year 1992, 34 batches and total amount 12 TBq of processed radioisotopes and 100 batches, 1.2 PBq of radiation sources were produced as scheduled. The development of the techniques for producing the sources emitting high energy β ray used for the diagnosis and treatment of cancer is in progress. The method of producing new isotopes is developed. (K.I.)

  3. Medical Radioisotope Scanning. Proceedings of a Seminar

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1959-07-01

    Of the many and varied uses of radioactive isotopes which have been developed in the past twenty years, their applications in medicine are among the most important. All over the world medical scientists have added radioisotopes to their armament in clinical research, diagnosis and radiotherapy. It is significant that the first scientific meeting organized by the International Atomic Energy Agency was devoted to a medical subject. It is not less significant as a symbol of the close co-operation which has been established between the Agency and other agencies of the United Nations family, that this first seminar was a joint undertaking with the World Health Organization. The determination of the distribution of a radioisotope within the human body - radioisotope scanning - is a technique which has made very rapid progress in the last few years in various medical centres throughout the world, and the necessity of providing an opportunity for an organized exchange of results, experience and opinions was clearly recognised. The value of such an exchange is demonstrated by the extensive discussions which took place and which are recorded in this volume, together with the original papers presented by those who have made such noteworthy contributions to progress in this field.

  4. Radioisotope applications on fluidized catalytic cracking units

    International Nuclear Information System (INIS)

    Charlton, J.S.

    1997-01-01

    Radioisotopes are used to trace the flow of all the phases of Fluidized Catalytic Cracking process in oil refineries. The gaseous phases, steam, hydrocarbon vapour and air, are generally traced using a noble-gas isotope, 41 Ar, 79 Kr or 85 Kr. An appropriate tracer for the catalyst is produced by irradiating a catalyst sample in a nuclear reactor. The activation products, 140 La and 24 Na provide appropriate radioactive 'labels' for the catalyst, which is reinjected into the FCC. An advantage of this approach is that it facilitates the study of the behaviour of different particle size fractions. Radioisotopes as sealed sources of gamma radiation are used to measure catalyst density variations and density distributions in critical parts of the unit. An important trend in radioisotope applications is the increasing use of the information they produce as inputs to or as validation of, mathematical process models. In line with the increasing sophistication of the models, the technology is undergoing continuous refinement. Developments include the investigation of more efficient, more convenient tracers, the introduction of systems to facilitate more rapid and comprehensive data acquisition and software refinements for enhanced data analysis

  5. (S)-4-(3-18F-fluoropropyl)-L-glutamic acid: an 18F-labeled tumor-specific probe for PET/CT imaging--dosimetry.

    Science.gov (United States)

    Smolarz, Kamilla; Krause, Bernd Joachim; Graner, Frank-Philipp; Wagner, Franziska Martina; Hultsch, Christina; Bacher-Stier, Claudia; Sparks, Richard B; Ramsay, Susan; Fels, Lüder M; Dinkelborg, Ludger M; Schwaiger, Markus

    2013-06-01

    The glutamic acid derivative (S)-4-(3-(18)F-Fluoropropyl)-l-glutamic acid ((18)F-FSPG, alias BAY 94-9392), a new PET tracer for the detection of malignant diseases, displayed promising results in non-small cell lung cancer patients. The aim of this study was to provide dosimetry estimates for (18)F-FSPG based on human whole-body PET/CT measurements. (18)F-FSPG was prepared by a fully automated 2-step procedure and purified by a solid-phase extraction method. PET/CT scans were obtained for 5 healthy volunteers (mean age, 59 y; age range, 51-64 y; 2 men, 3 women). Human subjects were imaged for up to 240 min using a PET/CT scanner after intravenous injection of 299 ± 22.5 MBq of (18)F-FSPG. Image quantification, time-activity data modeling, estimation of normalized number of disintegrations, and production of dosimetry estimates were performed using the RADAR (RAdiation Dose Assessment Resource) method for internal dosimetry and in general concordance with the methodology and principles as presented in the MIRD 16 document. Because of the renal excretion of the tracer, the absorbed dose was highest in the urinary bladder wall and kidneys, followed by the pancreas and uterus. The individual organ doses (mSv/MBq) were 0.40 ± 0.058 for the urinary bladder wall, 0.11 ± 0.011 for the kidneys, 0.077 ± 0.020 for the pancreas, and 0.030 ± 0.0034 for the uterus. The calculated effective dose was 0.032 ± 0.0034 mSv/MBq. Absorbed dose to the bladder and the effective dose can be reduced significantly by frequent bladder-voiding intervals. For a 0.75-h voiding interval, the bladder dose was reduced to 0.10 ± 0.012 mSv/MBq, and the effective dose was reduced to 0.015 ± 0.0010 mSv/MBq. On the basis of the distribution and biokinetic data, the determined radiation dose for (18)F-FSPG was calculated to be 9.5 ± 1.0 mSv at a patient dose of 300 MBq, which is of similar magnitude to that of (18)F-FDG (5.7 mSv). The effective dose can be reduced to 4.5 ± 0.30 mSv (at 300 MBq

  6. Radioisotopic synovectomy using ferric hydroxide macroaggregated for chronic arthritis treatment

    International Nuclear Information System (INIS)

    Lima, Carla Flavia; Campos, Tarcisio P.R.

    2002-01-01

    Synovectomy radioisotopic is an arthritis treatment used in specific clinical conditions whose main goal is to sterilized the synovia. This treatment has specific and precise indications and it is considered to have an adequate response. The present work presents a modeling of an articulation (joint) based on its real geometric anatomy and chemical constitution. The internal dosimetry is evaluated by the Monte Carlo Code. The majority of the radionuclides were considered in the simulations. The syntheses of the ferric hydroxide macroaggregates with dysprosium and samarium have been prepared (Dy 165 -MHF and Sm 153 -MHF). Obtaining the cintilographic images of rabbits in which Dy 165 -MHF is injected is in progress. Biodistribution studies in addition with the internal dosimetry will certify the dose in the membrane of the synovia. (author)

  7. Radioisotopic phlebography in investigating venous diseases of lower limbs

    International Nuclear Information System (INIS)

    San-Galli, F.; Vendaud-Busquet, M.; Philippe, J.C; Leccia, F.; Beylot, C.; Ducassous, D.

    1984-01-01

    The aim of this study is to analyse the interest of isotope phlebography in diagnosis of deep thrombosis and of chronic venous disease in the lower extremity as well as its value in relation to contrast venography. Out of 30 patients, 17 underwent both examinations. With contrast venography as a means of testing, radioisotope phlebography has a sensitivity of 71%, a specificity of 100%, an accuracy of 88%. Thirteen patients only had isotope phlebography. Results were confirmed everybody by clinical developments. The main interest of isotope phlebography is the diagnosis of femoral and iliac thromboses with a sensitivity and specificity of 100% at this point. In chronic venous disease isotope phlebography only shows indirect signs but gives information on the permeability of deep veins, wich is enough to make a therapeutic decision [fr

  8. Radioisotopic phlebography in investigating venous diseases of lower limbs

    Energy Technology Data Exchange (ETDEWEB)

    San-Galli, F.; Vendaud-Busquet, M.; Philippe, J.C; Leccia, F.; Beylot, C.; Ducassous, D. (Hopital du Haut-Leveque, 33 - Pessac (France))

    1984-10-01

    The aim of this study is to analyse the interest of isotope phlebography in diagnosis of deep thrombosis and of chronic venous disease in the lower extremity as well as its value in relation to contrast venography. Out of 30 patients, 17 underwent both examinations. With contrast venography as a means of testing, radioisotope phlebography has a sensitivity of 71%, a specificity of 100%, an accuracy of 88%. Thirteen patients only had isotope phlebography. Results were confirmed everybody by clinical developments. The main interest of isotope phlebography is the diagnosis of femoral and iliac thromboses with a sensitivity and specificity of 100% at this point. In chronic venous disease isotope phlebography only shows indirect signs but gives information on the permeability of deep veins, which is enough to make a therapeutic decision.

  9. Radioisotopic 51Cr-leukocyte adherence inhibition (LAI) assay. I

    International Nuclear Information System (INIS)

    Tsang, P.H.; Tangnavarad, K.; Lesnick, G.; Holland, J.F.; Bekesi, J.G.; Perloff, M.

    1980-01-01

    A simplified radioisotopic leukocyte adherence inhibition assay ( 51 Cr-LAI assay) was used to determine tumor-directed immune responses in patients with cancer of the breast. Essential steps in development of this assay are the standardization of conditions for optimal 51 Cr uptake by peripheral blood lymphocytes (PBL) and the inclusion of autologous or normal AB serum in the incubation media. A dextrose salt mixture (GNK) was found to enhance intracellular uptake of 51 Cr significantly (8-fold) without affecting viability of the cells or without causing selective loss of lymphocyte subpopulations. The presence of 10% autologous or normal AB serum prevented non-specific LAI responses to unrelated tumor antigens. Experimental results are presented and it is seen that this short term (4 h) 51 Cr-LAI assay provides reproducible and specific results analogous to those using tube-LAI assay. The test has the advantages of being accurate, sensitive and free from technical bias. (Auth.)

  10. A comparative study on PET and SPECT image formation systems for a proper scanner choice in a considered PET center

    International Nuclear Information System (INIS)

    Santos, G.R. dos; Oliveira, A. de; Oliveira, C.L. de

    2001-01-01

    precocious discovery of males. Presently multi-ring commercial PET scanners can operate in either two or three-dimensional acquisition modes. Some special features like the retractable lead septa allows 3-D acquisition. In this mode the overall scanner sensitivity has a remarkable increasing compared with earlier scanners, in spite of an increase in both the scatter and random rate. As the emission and transmission data are fed into the computers, and the coincidence events are stored as sinograms, it is also necessary to keep up with computational area. Just to give an idea on the complexity level, the software should be able to provide a full 2-D or 3-D reconstruction algorithm, based on filtered back projection, incorporating an attenuation correction procedure. This is necessary to characterize sinograms, which correspond to sets of two-dimensional projections of the tracer distribution. Software tools should also have the capability for image manipulation and ultimately using various bio-mathematical models. This way, the PET data could be transformed into information with physiological, pathological significance. In a self-sustained project, like the PET Center's project in Rio de Janeiro intend to be, the most important parameters to be considered in the equipment's choice are the per capita's income and acquisition and maintenance costs. However, these factors by itself cannot predict which the best equipment should be acquired and some inherent characteristic of the product as resolution, sensitivity, time of resolution, time of scan and others capabilities should be considered. Out of the comparative scenario, there are also some legal complies. Specifically connected to project of PET Center in Brazil, is the fact that the production of radioactive substances are monopoly of the federal government. As a consequence, and also considering that most PET radioisotopes are short-lived, the availability is restricted to this Southeastern region of Brazil. This region

  11. Textural features in pre-treatment [F18]-FDG-PET/CT are correlated with risk of local recurrence and disease-specific survival in early stage NSCLC patients receiving primary stereotactic radiation therapy.

    Science.gov (United States)

    Pyka, Thomas; Bundschuh, Ralph A; Andratschke, Nicolaus; Mayer, Benedikt; Specht, Hanno M; Papp, Laszló; Zsótér, Norbert; Essler, Markus

    2015-04-22

    Textural features in FDG-PET have been shown to provide prognostic information in a variety of tumor entities. Here we evaluate their predictive value for recurrence and prognosis in NSCLC patients receiving primary stereotactic radiation therapy (SBRT). 45 patients with early stage NSCLC (T1 or T2 tumor, no lymph node or distant metastases) were included in this retrospective study and followed over a median of 21.4 months (range 3.1-71.1). All patients were considered non-operable due to concomitant disease and referred to SBRT as the primary treatment modality. Pre-treatment FDG-PET/CT scans were obtained from all patients. SUV and volume-based analysis as well as extraction of textural features based on neighborhood gray-tone difference matrices (NGTDM) and gray-level co-occurence matrices (GLCM) were performed using InterView Fusion™ (Mediso Inc., Budapest). The ability to predict local recurrence (LR), lymph node (LN) and distant metastases (DM) was measured using the receiver operating characteristic (ROC). Univariate and multivariate analysis of overall and disease-specific survival were executed. 7 out of 45 patients (16%) experienced LR, 11 (24%) LN and 11 (24%) DM. ROC revealed a significant correlation of several textural parameters with LR with an AUC value for entropy of 0.872. While there was also a significant correlation of LR with tumor size in the overall cohort, only texture was predictive when examining T1 (tumor diameter 3 cm) subgroups. No correlation of the examined PET parameters with LN or DM was shown. In univariate survival analysis, both heterogeneity and tumor size were predictive for disease-specific survival, but only texture determined by entropy was determined as an independent factor in multivariate analysis (hazard ratio 7.48, p = .016). Overall survival was not significantly correlated to any examined parameter, most likely due to the high comorbidity in our cohort. Our study adds to the growing evidence that tumor

  12. Textural features in pre-treatment [F18]-FDG-PET/CT are correlated with risk of local recurrence and disease-specific survival in early stage NSCLC patients receiving primary stereotactic radiation therapy

    International Nuclear Information System (INIS)

    Pyka, Thomas; Bundschuh, Ralph A; Andratschke, Nicolaus; Mayer, Benedikt; Specht, Hanno M; Papp, Laszló; Zsótér, Norbert; Essler, Markus

    2015-01-01

    Textural features in FDG-PET have been shown to provide prognostic information in a variety of tumor entities. Here we evaluate their predictive value for recurrence and prognosis in NSCLC patients receiving primary stereotactic radiation therapy (SBRT). 45 patients with early stage NSCLC (T1 or T2 tumor, no lymph node or distant metastases) were included in this retrospective study and followed over a median of 21.4 months (range 3.1–71.1). All patients were considered non-operable due to concomitant disease and referred to SBRT as the primary treatment modality. Pre-treatment FDG-PET/CT scans were obtained from all patients. SUV and volume-based analysis as well as extraction of textural features based on neighborhood gray-tone difference matrices (NGTDM) and gray-level co-occurence matrices (GLCM) were performed using InterView Fusion™ (Mediso Inc., Budapest). The ability to predict local recurrence (LR), lymph node (LN) and distant metastases (DM) was measured using the receiver operating characteristic (ROC). Univariate and multivariate analysis of overall and disease-specific survival were executed. 7 out of 45 patients (16%) experienced LR, 11 (24%) LN and 11 (24%) DM. ROC revealed a significant correlation of several textural parameters with LR with an AUC value for entropy of 0.872. While there was also a significant correlation of LR with tumor size in the overall cohort, only texture was predictive when examining T1 (tumor diameter < = 3 cm) and T2 (>3 cm) subgroups. No correlation of the examined PET parameters with LN or DM was shown. In univariate survival analysis, both heterogeneity and tumor size were predictive for disease-specific survival, but only texture determined by entropy was determined as an independent factor in multivariate analysis (hazard ratio 7.48, p = .016). Overall survival was not significantly correlated to any examined parameter, most likely due to the high comorbidity in our cohort. Our study adds to the growing evidence

  13. PET imaging in pediatric neuroradiology: current and future applications

    International Nuclear Information System (INIS)

    Kim, Sunhee; Salamon, Noriko; Jackson, Hollie A.; Blueml, Stefan; Panigrahy, Ashok

    2010-01-01

    Molecular imaging with positron emitting tomography (PET) is widely accepted as an essential part of the diagnosis and evaluation of neoplastic and non-neoplastic disease processes. PET has expanded its role from the research domain into clinical application for oncology, cardiology and neuropsychiatry. More recently, PET is being used as a clinical molecular imaging tool in pediatric neuroimaging. PET is considered an accurate and noninvasive method to study brain activity and to understand pediatric neurological disease processes. In this review, specific examples of the clinical use of PET are given with respect to pediatric neuroimaging. The current use of co-registration of PET with MR imaging is exemplified in regard to pediatric epilepsy. The current use of PET/CT in the evaluation of head and neck lymphoma and pediatric brain tumors is also reviewed. Emerging technologies including PET/MRI and neuroreceptor imaging are discussed. (orig.)

  14. PET imaging in pediatric neuroradiology: current and future applications

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sunhee [Children' s Hospital of Pittsburgh of UPMC, Department of Radiology, Pittsburgh, PA (United States); Salamon, Noriko [UCLA David Geffen School of Medicine at UCLA, Department of Radiology, Ronald Reagan UCLA Medical Center, Los Angeles, CA (United States); Jackson, Hollie A.; Blueml, Stefan [Keck School of Medicine of USC, Department of Radiology, Childrens Hospital Los Angeles, Los Angeles, CA (United States); Panigrahy, Ashok [Children' s Hospital of Pittsburgh of UPMC, Department of Radiology, Pittsburgh, PA (United States); Keck School of Medicine of USC, Department of Radiology, Childrens Hospital Los Angeles, Los Angeles, CA (United States)

    2010-01-15

    Molecular imaging with positron emitting tomography (PET) is widely accepted as an essential part of the diagnosis and evaluation of neoplastic and non-neoplastic disease processes. PET has expanded its role from the research domain into clinical application for oncology, cardiology and neuropsychiatry. More recently, PET is being used as a clinical molecular imaging tool in pediatric neuroimaging. PET is considered an accurate and noninvasive method to study brain activity and to understand pediatric neurological disease processes. In this review, specific examples of the clinical use of PET are given with respect to pediatric neuroimaging. The current use of co-registration of PET with MR imaging is exemplified in regard to pediatric epilepsy. The current use of PET/CT in the evaluation of head and neck lymphoma and pediatric brain tumors is also reviewed. Emerging technologies including PET/MRI and neuroreceptor imaging are discussed. (orig.)

  15. Summary, the 20th quality control survey for radioisotopes in vitro tests in Japan, 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    For advancement of radioisotope in vitro tests such as radioimmunoassay and immunoradiometric assay, the Subcommittee for Radioisotope in vitro Test in Medical and Pharmaceutical Committee of Japan Radioisotope Association has conducted the yearly quality control survey for the test facilities in Japan since 1978. This is the summary of the 20th survey in 1998 where non-radioisotope tests like enzyme-immunoassay were involved as well. The survey was done for 143 facilities: 20 national and public university hospitals, 18 private university hospitals, 8 national hospitals, 13 public hospitals, 21 private hospitals, 41 hygienic laboratories and 22 manufacturers of reagents. Facilities examined intra- and between day-reproducibility, freeze-thaw effect and time change of the measured values on the same samples. Assays were for: growth hormone (h), somatomedin C, follicle stimulating h, luteinizing h, prolactin, thyroid stimulating h, triiodothyronines, thyroxines, thyroxine binding protein, calcitonin, insulin, C-peptide, glucagons, gastrin, testosterones, estradiol, progesterone, gonadotropin, 17{alpha}-hydroxyprogesterone, aldosterone, cortisol, dehydroepiandorosterone sulfate, renin, IgE, digoxin, {alpha}-fetoprotein, carcinoembryonic antigen, tissue polypeptide antigen, CA (125, 19-9 and 15-3), prostatic acid phosphatase, prostate specific antigen, {beta}2-microglobulin, ferritin, and neuron specific enolase. There was no great difference between this and last survey results although tendency of improvement was recognized. There were problems to be solved from the standpoint of clinical practice. (K.H.)

  16. {sup 18}F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with {sup 18}F-FDG and {sup 11}C-Methionine PET

    Energy Technology Data Exchange (ETDEWEB)

    Watabe, Tadashi [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan); Osaka University Graduate School of Medicine, PET Molecular Imaging Center, Osaka (Japan); Ikeda, Hayato; Aoki, Masanao [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan); Nagamori, Shushi; Wiriyasermkul, Pattama; Tanaka, Yoko; Hagiwara, Kohei; Kanai, Yoshikatsu [Osaka University Graduate School of Medicine, Department of Bio-system Pharmacology, Osaka (Japan); Naka, Sadahiro [Osaka University, Osaka University Graduate School of Medicine, Osaka University Hospital, Osaka (Japan); Kanai, Yasukazu [Osaka University Graduate School of Medicine, PET Molecular Imaging Center, Osaka (Japan); Osaka University Graduate School of Medicine, Department of Molecular Imaging in Medicine, Osaka (Japan); Shimosegawa, Eku [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan); Osaka University Graduate School of Medicine, PET Molecular Imaging Center, Osaka (Japan); Osaka University, Osaka University Graduate School of Medicine, Osaka University Hospital, Osaka (Japan); Hatazawa, Jun [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan); Osaka University Graduate School of Medicine, PET Molecular Imaging Center, Osaka (Japan); Osaka University, Immunology Frontier Research Center, Osaka (Japan)

    2017-02-15

    The purpose of this study was to evaluate the usefulness of L-4-borono-2-{sup 18}F-fluoro-phenylalanine ({sup 18}F-FBPA) as a tumor-specific probe, in comparison to {sup 18}F-FDG and {sup 11}C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. Cellular analyses of FBPA were performed to evaluate the transportability and K{sub m} value. PET studies were performed in rat xenograft models of C6 glioma (n = 12) and in rat models of turpentine oil-induced subcutaneous inflammation (n = 9). The kinetic parameters and uptake values on static PET images were compared using the one-tissue compartment model (K{sub 1}, k{sub 2}) and maximum standardized uptake value (SUVmax). The cellular analyses showed that FBPA had a lower affinity to a normal cell-type transporter LAT2 and induced less efflux through LAT2 among FBPA, Met, and BPA, while the efflux through LAT1 induced by FBPA was similar among the three compounds. The K{sub m} value of {sup 18}F-FBPA for LAT1 (196.8 ± 11.4 μM) was dramatically lower than that for LAT2 (2813.8 ± 574.5 μM), suggesting the higher selectivity of {sup 18}F-FBPA for LAT1. K{sub 1} and k{sub 2} values were significantly smaller in {sup 18}F-FBPA PET (K{sub 1} = 0.04 ± 0.01 ml/ccm/min and k{sub 2} = 0.07 ± 0.01 /min) as compared to {sup 11}C-Met PET (0.22 ± 0.09 and 0.52 ± 0.10, respectively) in inflammatory lesions. Static PET analysis based on the SUVmax showed significantly higher accumulation of {sup 18}F-FDG in the tumor and inflammatory lesions (7.2 ± 2.1 and 4.6 ± 0.63, respectively) as compared to both {sup 18}F-FBPA (3.2 ± 0.40 and 1.9 ± 0.19) and {sup 11}C-Met (3.4 ± 0.43 and 1.6 ± 0.11). No significant difference was observed between {sup 18}F-FBPA and {sup 11}C-Met in the static PET images. This study shows the utility of {sup 18}F-FBPA as a tumor-specific probe of LAT1 with low accumulation in the inflammatory lesions. (orig.)

  17. "1"8F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with "1"8F-FDG and "1"1C-Methionine PET

    International Nuclear Information System (INIS)

    Watabe, Tadashi; Ikeda, Hayato; Aoki, Masanao; Nagamori, Shushi; Wiriyasermkul, Pattama; Tanaka, Yoko; Hagiwara, Kohei; Kanai, Yoshikatsu; Naka, Sadahiro; Kanai, Yasukazu; Shimosegawa, Eku; Hatazawa, Jun

    2017-01-01

    The purpose of this study was to evaluate the usefulness of L-4-borono-2-"1"8F-fluoro-phenylalanine ("1"8F-FBPA) as a tumor-specific probe, in comparison to "1"8F-FDG and "1"1C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. Cellular analyses of FBPA were performed to evaluate the transportability and K_m value. PET studies were performed in rat xenograft models of C6 glioma (n = 12) and in rat models of turpentine oil-induced subcutaneous inflammation (n = 9). The kinetic parameters and uptake values on static PET images were compared using the one-tissue compartment model (K_1, k_2) and maximum standardized uptake value (SUVmax). The cellular analyses showed that FBPA had a lower affinity to a normal cell-type transporter LAT2 and induced less efflux through LAT2 among FBPA, Met, and BPA, while the efflux through LAT1 induced by FBPA was similar among the three compounds. The K_m value of "1"8F-FBPA for LAT1 (196.8 ± 11.4 μM) was dramatically lower than that for LAT2 (2813.8 ± 574.5 μM), suggesting the higher selectivity of "1"8F-FBPA for LAT1. K_1 and k_2 values were significantly smaller in "1"8F-FBPA PET (K_1 = 0.04 ± 0.01 ml/ccm/min and k_2 = 0.07 ± 0.01 /min) as compared to "1"1C-Met PET (0.22 ± 0.09 and 0.52 ± 0.10, respectively) in inflammatory lesions. Static PET analysis based on the SUVmax showed significantly higher accumulation of "1"8F-FDG in the tumor and inflammatory lesions (7.2 ± 2.1 and 4.6 ± 0.63, respectively) as compared to both "1"8F-FBPA (3.2 ± 0.40 and 1.9 ± 0.19) and "1"1C-Met (3.4 ± 0.43 and 1.6 ± 0.11). No significant difference was observed between "1"8F-FBPA and "1"1C-Met in the static PET images. This study shows the utility of "1"8F-FBPA as a tumor-specific probe of LAT1 with low accumulation in the inflammatory lesions. (orig.)

  18. PET reconstruction

    International Nuclear Information System (INIS)

    O'Sullivan, F.; Pawitan, Y.; Harrison, R.L.; Lewellen, T.K.

    1990-01-01

    In statistical terms, filtered backprojection can be viewed as smoothed Least Squares (LS). In this paper, the authors report on improvement in LS resolution by: incorporating locally adaptive smoothers, imposing positivity and using statistical methods for optimal selection of the resolution parameter. The resulting algorithm has high computational efficiency relative to more elaborate Maximum Likelihood (ML) type techniques (i.e. EM with sieves). Practical aspects of the procedure are discussed in the context of PET and illustrations with computer simulated and real tomograph data are presented. The relative recovery coefficients for a 9mm sphere in a computer simulated hot-spot phantom range from .3 to .6 when the number of counts ranges from 10,000 to 640,000 respectively. The authors will also present results illustrating the relative efficacy of ML and LS reconstruction techniques

  19. Radioisotopes for diagnosis in urology

    International Nuclear Information System (INIS)

    Galvan, G.

    1980-01-01

    A lecture, held on the occasion of the meeting, organized by the Austrian Company for Urology and the Bavarian Union of Urologists. Kidney diagnosis with means of nuclear medicine technology, scintigraphy of skeleton and candula suprarenalis as well as radioimmunological hormone determination are characterized by a non-invasive, valuable extension of the convential nephrourological diagnosis under a relatively low rate of radioactive emission. In the field of kidney diagnosis the specification of the function of each kidney by means of renography, sequence-scintigraphy and clearance must be regarded as an important factor, especially for the measurement of the degree of kidney damages. Therefore, it is also of a great pre-operative value in context with the determination of the functional capacity of a kidney, the control of prae-, -intra - and postrenal diseases, urological emergencies and the period after kidney-transplantations. The Tc-perfusion can be used for the diagnosis of kidney arterio-stenosis. In the field of skeleton scintigraphy with Tc-marked phosphates a very sensitive method for the discovery of metastasis is available. It can be applied as a screeningstest to the determination of the stage and to the control of the progress concerning the prostata carcinoma. The candula suprarenalis scintigraphy guarantees the differentiation of hormon producing tumors of the adrenalin gland in context with the determination of ACTH, cortisol, aldosteron, estrogens and testosteron. (F.R.)

  20. Evaluation of ambient radiation levels in positron emission tomography/computed tomography in microPET/CT laboratory; Avaliacao dos niveis de radiacao ambiental no laboratorio de tomografia por emissao de positrons acoplada a tomografia computadorizada, microPET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Sarmento, Daniele Martins

    2016-11-01

    Micro PET/CT scanner is an essential tool generally used for small animal molecular imaging. Fluorine-18-labeled fluorodeoxyglucose is the most widely used radioisotope in this technique. The present study aimed to evaluate the radiation levels in a micro PET/CT research laboratory of the Radiopharmacy Center at IPEN-CNEN / SP, in order to accomplish both national standards and international recommendations. The radioprotection team has classified the laboratory as supervised area; even this laboratory does not require the adoption of specific measures for protection and safety, should be done regular re-evaluation of the conditions of occupational exposures. Workplace monitoring and individual control assessment were carried out to ensure the radiological protection of all workers directly involved in handling the scanner. Initially, there was conducted a radiometric survey, as well as measurements of the external radiation level in the workplace and its surroundings. To achieve this goal, there were placed nine thermoluminescent dosimeters of CaSO{sub 4}:Dy in preselected locations. Monthly evaluations of the occupationally exposed individuals were carried out through the use of TL dosimeters, ported in the workers' chest. Moreover, whole body measurements were performed every six months. The study period was about two-years which started in April 2014. All tests to evaluate micro PET/CT performance were based on the standard protocol of the equipment in accordance with the standard developed by the Animal PET Standard Task Force. Present study's results demonstrated that the ambient radiation levels (ambient and effective estimated radiation dose), as well as the effective shielding equipment are both adequate. This study emphasizes that it is essential to strictly follow the principles of radioprotection in workplace, whenever researches involve radioactive unsealed sources. (author)

  1. Suggestion for improvement of PET quality control tests in Brazil

    International Nuclear Information System (INIS)

    Ferreira, Fernanda C.L.; Magalhaes, Cinthia M.S.; Souza, Divanizia N.

    2009-01-01

    Nowadays nuclear medicine has a considerable importance among the other medical specialties. This medical specialty utilizes high-tech equipment for imaging in the diagnosis, obtaining information on the clinical functionality of organs and systems of the human body through the use of radioisotopes . In view of the importance of guaranteeing the image quality in SPECT and PET systems, enabling patients not repeat exams due to lack of quality control of equipment used in nuclear medicine, this paper aims to present a possible suggestion to update the quality control tests needed for quality assurance of nuclear medicine services. They were considered the requirements of the National Commission of Nuclear Energy (CNEN) and the National Health Surveillance Agency (ANVISA) in Brazil. The minimum requirements to be defined for inclusion of quality control tests on PET in the standard CNEN are extremely important because they will guide the evaluation of PET systems, determining the quality control tests to be performed. And those tests for PET will be a regulatory requirement by the CNEN and ANVISA. As the National Health Surveillance Agency has already publication of RDC 38 with recommendations for services of nuclear medicine. This study will continue with evaluation of PET systems and presenting the tests of quality control with additional objects and simulators to ensure safety in PET systems have not standardized in nuclear medicine services in Brazil. (author)

  2. Radioisotope techniques for problem-solving on refineries

    International Nuclear Information System (INIS)

    Charlton, J.S.; Webb, M.

    1994-01-01

    Increasingly, refineries worldwide are recognizing the value of radioisotope technology in studying the operation of on-line plant. Using case studies, this paper illustrates the versatility of radioisotope techniques in a wide range of investigations: the density-profiling of distillation columns; the investigation of leaks on feed/effluent exchangers; on-line flowrate measurement; underground leakage detection. The economic benefits deriving from radioisotope applications are indicated

  3. HAC and production of radioisotopes and labelled compounds

    International Nuclear Information System (INIS)

    Nozaki, T.

    1984-01-01

    In this paper, the author reviews different methods for the production of radioisotopes and labelled compounds that make use of hot atom reactions. Subsequently he discusses the production of radioisotopes for radiopharmaceuticals; enrichment of (n,γ) products, recoil labelling and related methods (neutron reaction products, cyclotron production, excitation labelling, radiation and discharge induced labelling). The final section offers a survey of radioisotope production using accelerators. Only a selection of the various conditions used in practical RI production is considered. (Auth.)

  4. A report on the extent of radioisotope usage in Malaysia

    International Nuclear Information System (INIS)

    1983-04-01

    A market survey was carried out to study the extent of radioisotope usage in Malaysia. From the survey, the radioisotopes and their activities/quantities that are used in Industry, Medicine and Research were identified. The radioisotopes that are frequently needed or routinely used were also determined and this formed the basis of the recommendations put forward in this report. It is proposed that PUSPATI adopt the concept of a Distribution Centre in order to provide a service to the Malaysian community. (author)

  5. The Research and Development of the Radioisotope Energy Conversion System

    International Nuclear Information System (INIS)

    Steinfelds, E.V.; Ghosh, T.K.; Prelas, M.A.; Tompson, R.V.; Loyalka, S.K.

    2001-01-01

    The project of developing radioisotope energy conversion system (RECS) involves analytical computational assisted design and modeling and also laboratory research. The computational analysis consists of selecting various geometries and materials for the main RECS container and the internally located radioisotope, computing the fluxes of the beta (-) particles and of the visible (or ultraviolet) photons produced by the beta (-) s, computing the transport of these photons to the photovoltaic cells, and computing the overall efficiency of useful conversion of the radioisotope power

  6. Evaluation of ambient radiation levels in positron emission tomography/computed tomography in microPET/CT laboratory

    International Nuclear Information System (INIS)

    Sarmento, Daniele Martins

    2016-01-01

    Micro PET/CT scanner is an essential tool generally used for small animal molecular imaging. Fluorine-18-labeled fluorodeoxyglucose is the most widely used radioisotope in this technique. The present study aimed to evaluate the radiation levels in a micro PET/CT research laboratory of the Radiopharmacy Center at IPEN-CNEN / SP, in order to accomplish both national standards and international recommendations. The radioprotection team has classified the laboratory as supervised area; even this laboratory does not require the adoption of specific measures for protection and safety, should be done regular re-evaluation of the conditions of occupational exposures. Workplace monitoring and individual control assessment were carried out to ensure the radiological protection of all workers directly involved in handling the scanner. Initially, there was conducted a radiometric survey, as well as measurements of the external radiation level in the workplace and its surroundings. To achieve this goal, there were placed nine thermoluminescent dosimeters of CaSO 4 :Dy in preselected locations. Monthly evaluations of the occupationally exposed individuals were carried out through the use of TL dosimeters, ported in the workers' chest. Moreover, whole body measurements were performed every six months. The study period was about two-years which started in April 2014. All tests to evaluate micro PET/CT performance were based on the standard protocol of the equipment in accordance with the standard developed by the Animal PET Standard Task Force. Present study's results demonstrated that the ambient radiation levels (ambient and effective estimated radiation dose), as well as the effective shielding equipment are both adequate. This study emphasizes that it is essential to strictly follow the principles of radioprotection in workplace, whenever researches involve radioactive unsealed sources. (author)

  7. The law concerning prevention from radiation hazards due to radioisotopes

    International Nuclear Information System (INIS)

    1984-01-01

    The law regulates uses, sales and disposal of radioisotopes, uses of radiation generating apparatuses, disposal of materials contaminated with radioisotopes, and so on, in accordance with the Atomic Energy Fundamental Act, for public safety. Covered are the following: permission for and notification of the uses and permission for businesses selling and disposing of radioisotopes, and approval of designs concerning radiation hazard prevention mechanisms, obligations of the users and business enterprises selling and disposing of radioisotopes, the licensed engineers of radiation, organs, etc. for confirmation of the mechanisms, punitive provisions, and so on. (Mori, K.)

  8. Efficient, Long-Lived Radioisotope Power Generator, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Radiation Monitoring Devices, Inc., (RMD) proposes to develop an alternative very long term, radioisotope power source with thermoelectric power conversion with...

  9. Vitrified chemically bonded phosphate ceramics for immobilization of radioisotopes

    Science.gov (United States)

    Wagh, Arun S.

    2016-04-05

    A method of immobilizing a radioisotope and vitrified chemically bonded phosphate ceramic (CBPC) articles formed by the method are described. The method comprises combining a radioisotope-containing material, MgO, a source of phosphate, and optionally, a reducing agent, in water at a temperature of less than 100.degree. C. to form a slurry; curing the slurry to form a solid intermediate CBPC article comprising the radioisotope therefrom; comminuting the intermediate CBPC article, mixing the comminuted material with glass frits, and heating the mixture at a temperature in the range of about 900 to about 1500.degree. C. to form a vitrified CBPC article comprising the radioisotope immobilized therein.

  10. Technical and economical availability of radioisotopes production in Brazil

    International Nuclear Information System (INIS)

    Lima, J.O.V.

    1981-10-01

    The technical and economical availability of radioisotopes production in Brazil by a low power research reactor, are done. The importance of radioisotope utilization and controled radiations, in areas such as medicine, industry and cost evaluation for the production in nuclear reactors. In the cost evaluation of a radioisotope production reactor, the studies developed by the Department of Nuclear Engineering of Universidade Federal de Minas Gerais - DEN/UFMG were used. The information analysis justify the technical and economical availability and the necessity of the radioisotopes production in Brazil. (E.G.) [pt

  11. Production and application of radioisotopes in Asian Countries

    International Nuclear Information System (INIS)

    He Youfeng

    1997-01-01

    Production and application of radioisotopes in some Asian countries including Bangladesh, India, Indonesia, Iran, Japan, Republic of Korea, Malaysia, Pakistan, Philippines, Thailand, Uzbekistan, and Viet Nam are introduced

  12. An AU-rich element in the 3{prime} untranslated region of the spinach chloroplast petD gene participates in sequence-specific RNA-protein complex formation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Qiuyun; Adams, C.C.; Usack, L. [Cornell Univ., Ithaca, NY (United States)] [and others

    1995-04-01

    In chloroplasts, the 3{prime} untranslated regions of most mRNAs contain a stem-loop-forming inverted repeat (IR) sequence that is required for mRNA stability and correct 3{prime}-end formation. The IR regions of several mRNAs are also known to bind chloroplast proteins, as judged from in vitro gel mobility shift and UV cross-linking assays, and these RNA-protein interactions may be involved in the regulation of chloroplast mRNA processing and/or stability. Here we describe in detail the RNA and protein components that are involved in 3{prime} IR-containing RNA (3{prime} IR-RNA)-protein complex formation for the spinach chloroplast petD gene, which encodes subunit IV of the cytochrome b{sub 6}/f complex. We show that the complex contains 55-, 41-, and 29-kDa RNA-binding proteins (ribonucleoproteins [RNPs]). These proteins together protect a 90-nucleotide segment of RNA from RNase T{sub 1} digestion; this RNA contains the IR and downstream flanking sequences. Competition experiments using 3{prime} IR-RNAs from the psbA or rbcL gene demonstrate that the RNPs have a strong specificity for the petD sequence. Site-directed mutagenesis was carried out to define the RNA sequence elements required for complex formation. These studies identified an 8-nucleotide AU-rich sequence downstream of the IR; mutations within this sequence had moderate to severe effects on RNA-protein complex formation. Although other similar sequences are present in the petD 3{prime} untranslated region, only a single copy, which we have termed box II, appears to be essential for in vivo protein binding. In addition, the IR itself is necessary for optimal complex formation. These two sequence elements together with an RNP complex may direct correct 3{prime}-end processing and/or influence the stability of petD mRNA in chloroplasts. 48 refs., 9 figs., 2 tabs.

  13. PET imaging in breast cancer

    International Nuclear Information System (INIS)

    Bombardieri, E.; Crippa, F.

    2001-01-01

    The basis of tumour imaging with PET is a specific uptake mechanism of positron emitting radiopharmaceuticals. Among the potential tracers for breast cancer (fluorodeoxyglucose, methionine, tyrosine, fluoro-estradiol, nor-progesterone), 2-deoxy-2-fluoro-D-glucose labelled with fluorine (FDG) is the most widely used radiopharmaceutical because breast cancer is particularly avid of FDG and 18 F has the advantages of the a relatively long physical half-life. Mammography is the first choice examination in studying breast masses, due to its very good performances, an excellent compliance and the best value regarding the cost/effectiveness aspects. The FDG uptake in tissue correlates with the histological grade and potential aggressiveness of breast cancer and this may have prognostic consequences. Besides the evaluation of breast lesions, FDG-PET shows a great efficacy in staging lymph node involvement prior surgery and this could have a great value in loco-regional staging. Whole body PET provides also information with regard to metastasis localizations both in soft tissue and bone, and plays an important clinical role mainly in detecting recurrent metastatic disease. In fact for its metabolic characteristics PET visualizes regions of enhanced metabolic activity and can complete other imaging modalities based on structural anatomic changes. Even though CT and MRI show superior resolution characteristics, it has been demonstrated that PET provides more accurate information in discriminating between viable tumour, fibrotic scar or necrosis. These statements are coming from the examination of more than 2000 breast cancer detection

  14. Radioisotope heart examination during exercise to diagnose ischemic heart disease

    International Nuclear Information System (INIS)

    Farsky, S.

    1986-01-01

    The radioisotope exercise test is discussed and its benefits characterized for the diagnosis of ischemic heart disease, namely the use of 99m Tc in scintiscanning heart ventricles and of 201 Tl in scintiscanning myocardial perfusion. The exercise ventricular function and perfusion scintigraphies are compared with the common exercise ECG examination, and their superior sensitivity and specificity emphasized. Considering the constraints of scintigraphic imaging, indications are outlined for patients including those with suspect serious ischemic heart disease in whom the exercise ECG test has been negative or inconclusive, patients with the so-called nondiagnostic ECG, patients with atypical symptoms, and healthy individuals for whom the exercise ECG test indicated with respect to their occupation has been positive. Both radionuclide imaging techniques are complementary and are shown to be valuable not only in improving the diagnosis of ischemic heart disease but also in identifying the high-risk patients in whom cardiac surgery is to be considered. (L.O.)

  15. Radioisotopes as tools in food and nutrition research

    International Nuclear Information System (INIS)

    Florentino, R.F.

    1996-01-01

    In the Philippines as in many developing countries, protein-energy malnutrition, vitamin A, iron and iodine deficiencies continue to pose serious health problems particularly in children, pregnant and lactating women. These problems as per World Declaration on Nutrition adopted by government ministers and senior policy makers from more than 150 countries, should be dramatically reduced if not virtually eliminated by the year 2000. The rapid advances in isotope techniques contributed significantly to a greater and better understanding of the quantitative relationships of diets, nutrients and health. While it is recognized that isotopic techniques have a wide variety of application in human nutrition, this paper will focus on how radioisotopes may be applied in clarifying nutritional problems specifically iron, iodine and vitamin A deficiency and how such knowledge is applied in developing practical methods for eliminating them. (author)

  16. Trends in PET imaging

    International Nuclear Information System (INIS)

    Moses, William W.

    2000-01-01

    Positron Emission Tomography (PET) imaging is a well established method for obtaining information on the status of certain organs within the human body or in animals. This paper presents an overview of recent trends PET instrumentation. Significant effort is being expended to develop new PET detector modules, especially those capable of measuring depth of interaction. This is aided by recent advances in scintillator and pixellated photodetector technology. The other significant area of effort is development of special purpose PET cameras (such as for imaging breast cancer or small animals) or cameras that have the ability to image in more than one modality (such as PET / SPECT or PET / X-Ray CT)

  17. [F-18]FDG imaging of head and neck tumors: comparison of hybrid PET, dedicated PET and CT

    International Nuclear Information System (INIS)

    Dresel, S.; Brinkbaeumer, K.; Schmid, R.; Poepperl, G.; Hahn, K.; Szeimies, U.

    2001-01-01

    Aim: Aim of the study was to evaluate [F-18]FDG imaging of head and neck tumors using a Hybrid-PET device of the 2nd or 3rd generation. Examinations were compared to dedicated PET and Spiral-CT. Methods: 54 patients suffering from head and neck tumors were examined using dedicated PET and Hybrid-PET after injection of 185-350 MBq [F-18]FDG. Examinations were carried out on the dedicated PET first followed by a scan on the Hybrid-PET. Dedicated PET was acquired in 3D mode, Hybrid-PET was performed in list mode using an axial filter. Reconstruction of data was performed iteratively on both, dedicated PET and Hybrid-PET. All patients received a CT scan in multislice technique. All finding have been verified by the goldstandard histology or in case of negative histology by follow up. Results: Using dedicated PET the primary or recurrent lesion was correctly diagnosed in 47/48 patients, using Hybrid-PET in 46/48 patients and using CT in 25/48 patients. Metastatic disease in cervical lymph nodes was diagnosed in 17/18 patients with dedicated PET, in 16/18 patients with Hybrid-PET and in 15/18 with CT. False positive results with regard to lymph node metastasis were seen with one patient for dedicated PET and Hybrid-PET, respectively, and with 18 patients for CT. In a total of 11 patients unknown metastastic lesions were seen with dedicated PET and with Hybrid-PET elsewhere in the body. Additional malignant disease other than the head and neck tumor was found in 4 patients. Conclusion: Using Hybrid-PET for [F-18]FDG imaging reveals a loss of sensitivity and specificity of about 1-5% as compared to dedicated PET in head and neck tumors. [F-18]FDG PET with both, dedicated PET and Hybrid-PET is superior to CT in the diagnosis of primary or recurrent lesions as well as in the assessment of lymph node involvement. (orig.) [de

  18. Kinetic modeling in PET imaging of hypoxia

    Science.gov (United States)

    Li, Fan; Joergensen, Jesper T; Hansen, Anders E; Kjaer, Andreas

    2014-01-01

    Tumor hypoxia is associated with increased therapeutic resistance leading to poor treatment outcome. Therefore the ability to detect and quantify intratumoral oxygenation could play an important role in future individual personalized treatment strategies. Positron Emission Tomography (PET) can be used for non-invasive mapping of tissue oxygenation in vivo and several hypoxia specific PET tracers have been developed. Evaluation of PET data in the clinic is commonly based on visual assessment together with semiquantitative measurements e.g. standard uptake value (SUV). However, dynamic PET contains additional valuable information on the temporal changes in tracer distribution. Kinetic modeling can be used to extract relevant pharmacokinetic parameters of tracer behavior in vivo that reflects relevant physiological processes. In this paper, we review the potential contribution of kinetic analysis for PET imaging of hypoxia. PMID:25250200

  19. Development of radioisotope preparation and application technology

    Energy Technology Data Exchange (ETDEWEB)

    Han, Hyon Soo; Park, K. B.; Bang, H. S. [and others

    2000-04-01

    The purpose of this project is to develop RI production technology utility 'HANARO' and to construct a sound infra-structure for mass production and supply to domestic users. The developed contents and results are as follows: two types of rig for irradiation in reactor core were designed and manufactured. The safety of OR rig during irradiation was identified through various test and it is used for RI production. The prepared IR rig will be used to performance tests for safety. We prepared two welders and welding jigs for production of sealed sources, and equipments for quality control of the welded materials. Production processes and apparatus Cr-51, P-32, I-125 and Sr-89, were developed. Developed results would be used for routine production and supply of radioisotopes. The automatic Tc-99m extraction apparatus was supplied to Libya under IAEA support. For approval on special form radioactive material of the developed Ir-192 source assembly and projector documents were prepared and submitted to MOST. The high dose rate Ir-192 source(diameter 1.1 mm, length 5.2 mm) for RALS and the laser welding system for its fabrication were developed. Production technologies of Ir-192 sources for destructive test and medical therapy were transferred to private company for commercial supply. The chemical immobilization method based on the self-assemble monolayer of {omega}-functionalized thiol and the sensing scheme based on the beta-emitter labeling method were developed for the fabrication radioimmuno-sensors. Results of this study will be applied to mass production of radioisotopes 'HANARO' and are to contribute the advance of domestic medicine and industry related to radioisotopes.

  20. A new radioisotope facility for Thailand

    International Nuclear Information System (INIS)

    Horlock, K.

    1997-01-01

    The Thai Office of Atomic Energy for Peace (OAEP) is planning a new Nuclear Research Centre which will be located at Ongkharak, a greenfield site some 100 km North of Bangkok. General Atomics (GA) has submitted a bid for a turnkey contract for the core facilities comprising a Reactor to be supplied by GA, an Isotope Production Facility supplied by ANSTO and a Waste Processing and Storage Facility to be supplied by Hitachi through Marubeni. The buildings for these facilities will be provided by Raytheon, the largest constructor of nuclear facilities in the USA. The proposed Isotope Facility will consist of a 3000 m 2 building adjacent to the reactor with a pneumatic radioisotope transfer system. Hot cells, process equipment and clean rooms will be provided, as well as the usual maintenance and support services required for processing radiopharmaceutical and industrial products. To ensure the highest standards of product purity the processing areas will be supplied with clean air and operated at slightly positive pressure. The radioisotopes to be manufactured include Phosphorus 32 (S-32 [n,p]P-32), I-131(Te-130 [n,g]Te-131[p]I-131) for bulk, diagnostic capsules and therapeutic capsules, Iridium 192 (Ir-191[n,g]Ir-192) wire for radiotherapy and discs for industrial radiography sources and bulk Iodine 125 (Xe-124[n,g]Xe-125[β]I-125 for radioimmunoassay. The bid includes proposals for training OAEP staff during design and development at ANSTO's radioisotope facilities, and during construction and commissioning in Thailand. The entire project is planned to take four years with commencement anticipated in early 1997. The paper will describe the development of the design of the hot-cells, process equipment, building layout and ventilation and other services

  1. Recent progress in radioisotope production in Vietnam

    Energy Technology Data Exchange (ETDEWEB)

    So, Le Van [Radioisotope Dept., Nuclear Research Institute, Dalat (Viet Nam)

    1998-10-01

    This is a report on the recent progress in radioisotope production in Vietnam. Using a nuclear research reactor of 500 KW with continuous operation cycles of 100 hours a month, the production of some important radioisotopes used in nuclear medicine and research was routinely carried out. More than 80 per cent of irradiation capacity of reactor for radioisotope production were exploited. The radioactivity of more than 150 Ci of {sup 131}I, {sup 99}Mo-{sup 99m}Tc, {sup 32}P, {sup 51}Cr, {sup 153}Sm, {sup 46}Sc, {sup 192}Ir was produced annually. Radiopharmaceuticals such as {sup 131}I-Hippuran and in-vivo Kits for {sup 99m}Tc labelling were also prepared routinely and regularly. More than 10 in-vivo Kits including modern radiopharmaceuticals such as HmPAO kit were supplied to hospitals in Vietnam. The research on the improvement of dry distillation technology for production of {sup 131}I was carried out. As a result obtained a new distillation apparatus made from glass was successfully put to routine use in place of expensive quartz distillation furnace. We have also continued the research programme on the development of {sup 99m}Tc generators using low power research reactors. Gel technology using Zr- and Ti- molybdate gel columns for {sup 99m}Tc generator production was developed and improved continually. Portable {sup 99m}Tc generator using Zr-({sup 99}Mo) molybdate gel column and ZISORB adsorbent column for {sup 99m}Tc concentration were developed. The ZISORB adsorbent of high adsorption capacity for {sup 99}Mo and other parent radionuclides was also studied for the development purpose of alternative technology of {sup 99m}Tc and other different radionuclide generator systems. The studies on the preparation of therapeutic radiopharmaceuticals labelling with {sup 153}Sm and {sup 131}I such as {sup 153}Sm-EDTMP, {sup 131}I-MIBG were carried out. (author)

  2. Development of radioisotope preparation and application technology

    International Nuclear Information System (INIS)

    Han, Hyon Soo; Park, K. B.; Bang, H. S. and others

    2000-04-01

    The purpose of this project is to develop RI production technology utility 'HANARO' and to construct a sound infra-structure for mass production and supply to domestic users. The developed contents and results are as follows: two types of rig for irradiation in reactor core were designed and manufactured. The safety of OR rig during irradiation was identified through various test and it is used for RI production. The prepared IR rig will be used to performance tests for safety. We prepared two welders and welding jigs for production of sealed sources, and equipments for quality control of the welded materials. Production processes and apparatus Cr-51, P-32, I-125 and Sr-89, were developed. Developed results would be used for routine production and supply of radioisotopes. The automatic Tc-99m extraction apparatus was supplied to Libya under IAEA support. For approval on special form radioactive material of the developed Ir-192 source assembly and projector documents were prepared and submitted to MOST. The high dose rate Ir-192 source(diameter 1.1 mm, length 5.2 mm) for RALS and the laser welding system for its fabrication were developed. Production technologies of Ir-192 sources for destructive test and medical therapy were transferred to private company for commercial supply. The chemical immobilization method based on the self-assemble monolayer of ω-functionalized thiol and the sensing scheme based on the beta-emitter labeling method were developed for the fabrication radioimmuno-sensors. Results of this study will be applied to mass production of radioisotopes 'HANARO' and are to contribute the advance of domestic medicine and industry related to radioisotopes

  3. List of DOE radioisotope customers with summary of radioisotope shipments FY 1978

    International Nuclear Information System (INIS)

    Burlison, J.S.; Laidler, R.I.

    1979-05-01

    The purpose of the document is to list DOE's radioisotopes production and distribution activities by its facilities at Argonne National Laboratory; Pacific Northwest Laboratory; Brookhaven National Laboratory; Hanford Engineering Development Laboratory; Idaho Operations Office; Los Alamos Scientific Laboratory; Mound Facility; Oak Ridge National Laboratory; Savannah River Laboratory; and UNC Nuclear Industries, Inc

  4. Digital radioisotope moisture-density meter

    International Nuclear Information System (INIS)

    Bychvarov, N.; Vankov, I.; Dimitrov, L.

    1982-01-01

    The primary information from the detectors of a combined radioisotope moisture-density meter is obtained as pulses, their counting rate being functionally dependent on the humidity per unit volume and the wet density. However, most practical cases demand information on the moisture per unit weight and the mass density of the dry skeleton. The paper describes how the proposed electronic circuit processes the input primary information to obtain the moisture in weight % and the mass density of the dry skeleton in g/cm 3 . (authors)

  5. Industrial measurement instruments that use radioisotopes

    International Nuclear Information System (INIS)

    Monno, Asao

    2004-01-01

    An example of a large-scale system for controlling hot rolling, and recent developments for a gamma-ray thickness gauge for the inner-mill housing of a plate and a thickness gauge for a hot seamless tube mill are introduced. The dramatically higher speed response, versatile intelligent elements, larger data capacity and formation of a database are advantages of these instruments over conventional devices. Moreover, Fuji Electric's industrial measuring instruments that use radioisotopes are manufactured and marketed to be compatible with those of Hitachi, and we have already compiled a track record of many deliveries. (author)

  6. Radioisotope Thermoelectric Generator Transport Trailer System

    International Nuclear Information System (INIS)

    Ard, K.E.; King, D.A.; Leigh, H.; Satoh, J.A.

    1994-01-01

    The Radioisotope Thermoelectric Generator (RTG) Transportation System, designated as System 100, comprises four major systems. The four major systems are designated as the Packaging System (System 120), Trailer System (System 140), Operations and Ancillary Equipment System system 160), and Shipping and Receiving Facility Transport System (System 180). Packaging System (System 120), including the RTG packaging is licensed (regulatory) hardware; it is certified by the US Department of Energy to be in accordance with Title 10, Code of federal Regulations, Part 71 (10 CFR 71). System 140, System 160, and System 180 are nonlicensed (nonregulatory) hardware

  7. Design of shipping packages to transport varying radioisotopic source materials for future space and terrestrial missions

    International Nuclear Information System (INIS)

    Barklay, C.D.

    1995-01-01

    The exploration of space will begin with manned missions to the moon and to Mars, first for scientific discoveries, then for mining and manufacturing. Because of the great financial costs of this type of exploration, it can only be accomplished through an international team effort. This unified effort must include the design, planning and, execution phases of future space missions, extending down to such activities as isotope processing, and shipping package design, fabrication, and certification. All aspects of this effort potentially involve the use of radioisotopes in some capacity, and the transportation of these radioisotopes will be impossible without a shipping package that is certified by the Nuclear Regulatory Commission or the U.S. Department of Energy for domestic shipments, and the U.S. Department of Transportation or the International Atomic Energy Agency for international shipments. To remain without the international regulatory constraints, and still support the needs of new and challenging space missions conducted within ever-shrinking budgets, shipping package concepts must be innovative. A shipping package must also be versatile enough to be reconfigured to transport the varying radioisotopic source materials that may be required to support future space and terrestrial missions. One such package is the Mound USA/9516/B(U)F. Taking into consideration the potential need to transport specific types of radioisotopes, approximations of dose rates at specific distances were determined taking into account the attenuation of dose rate with distance for varying radioisotopic source materials. As a result, it has been determined that the shipping package requirements that will be demanded by future space (and terrestrial) missions can be met by making minor modifications to the USA/9516/B(U)F. copyright 1995 American Institute of Physics

  8. Clinical PET/CT imaging. Promises and misconceptions

    International Nuclear Information System (INIS)

    Czernin, J.; Auerbach, M.A.

    2005-01-01

    PET/CT is now established as the most important imaging tool in oncology. PET/CT stages and restages cancer with a higher accuracy than PET or CT alone. The sometimes irrational approach to combine state of the art PET with the highest end CT devices should give way to a more reasonable equipment design tailored towards the specific clinical indications in well-defined patient populations. The continuing success of molecular PET/CT now depends more upon advances in molecular imaging with the introduction of targeted imaging probes for individualized therapy approaches in cancer patients and less upon technological advances of imaging equipment. (orig.)

  9. PET / MRI vs. PET / CT. Indications Oncology

    International Nuclear Information System (INIS)

    Oliva González, Juan P.

    2016-01-01

    Hybrid techniques in Nuclear Medicine is currently a field in full development for diagnosis and treatment of various medical conditions. With the recent advent of PET / MRI much it speculated about whether or not it is superior to PET / CT especially in oncology. The Conference seeks to clarify this situation by dealing issues such as: State of the art technology PET / MRI; Indications Oncology; Some clinical cases. It concludes by explaining the oncological indications of both the real and current situation of the PET / MRI. (author)

  10. Industrial radioisotope economics. Findings of the study group

    International Nuclear Information System (INIS)

    1965-01-01

    Within twenty years of the availability of radioisotopes in quantity the use of these as tracers has been widely applied in scientific research and in industrial process and product control. Industry spends millions of dollars on these new techniques. Since the overall attitude of industry is to favour methods that involve rapid financial returns the economic benefits must be considerable. In promoting the peaceful uses of atomic energy, the IAEA is actively interested in the international exchange of experience in all applications of radioisotopes. This has been demonstrated by a number of scientific conferences where new results of direct importance to the industrial use of radioisotopes have been presented. In 1963 the IAEA also published literature survey on radioisotope applications described in the scientific literature up to 1960, classified according to industry. However, the available scientific literature was found insufficient to determine the extent of the use of radioisotopes and the economic benefits derived from it. Therefore, further fact-finding efforts were necessary. The IAEA thus decided to carry out an International Survey on the Use of Radioisotopes in Industry. In 1962 the IAEA's highly industrialized Member States Were invited to participate in the Survey; 25 declared their willingness to do so and in due course submitted their national reports. These included information on how radioisotopes were used by industry in each country and indicated the size and form of the economic advantages, primarily in terms of savings made by industry. The findings from the Survey were discussed at a Study Group Meeting on Radioisotope Economics, held in Vienna in March 1964. Forty participants from 22 countries were nominated for this Study Group. The program of the meeting was divided in three parts: (1) experience of the International Survey on the use of radioisotopes in industry; (2) present use of radioisotopes, technical and economic aspects; (3

  11. Charged particle cross-section database for medical radioisotope production: diagnostic radioisotopes and monitor reactions. Final report of a co-ordinated research project

    International Nuclear Information System (INIS)

    2001-05-01

    Medical applications of nuclear radiation are of considerable interest to the IAEA. Cyclotrons and accelerators, available in recent years in an increasing number of countries, are being used for the production of radioisotopes for both diagnostic and therapeutic purposes. The physical basis of this production is described through interaction of charged particles, such as protons, deuterons and alphas, with matter. These processes have to be well understood in order to produce radioisotopes in an efficient and clean manner. In addition to medical radioisotope production, reactions with low energy charged particles are of primary importance for two major applications. Techniques of ion beam analysis use many specific reactions to identify material properties, and in nuclear astrophysics there is interest in numerous reaction rates to understand nucleosynthesis in the Universe. A large number of medically oriented cyclotrons have been running in North America, western Europe and Japan for more than two decades. In recent years, 30-40 MeV cyclotrons and smaller cyclotrons (E p < 20 MeV) have been installed in several countries. Although the production methods are well established, there are no evaluated and recommended nuclear data sets available. The need for standardization was thus imminent. This was pointed out at three IAEA meetings. Based on the recommendations made at these meetings, the IAEA decided to undertake and organize the Co-ordinated Research Project (CRP) on Development of Reference Charged Particle Cross-Section Database for Medical Radioisotope Production. The project was initiated in 1995. It focused on radioisotopes for diagnostic purposes and on the related beam monitor reactions in order to meet current needs. It constituted the first major international effort dedicated to standardization of nuclear data for radioisotope production. It covered the following areas: Compilation of data on the most important reactions for monitoring light ion

  12. Similarities between obesity in pets and children: the addiction model.

    Science.gov (United States)

    Pretlow, Robert A; Corbee, Ronald J

    2016-09-01

    Obesity in pets is a frustrating, major health problem. Obesity in human children is similar. Prevailing theories accounting for the rising obesity rates - for example, poor nutrition and sedentary activity - are being challenged. Obesity interventions in both pets and children have produced modest short-term but poor long-term results. New strategies are needed. A novel theory posits that obesity in pets and children is due to 'treats' and excessive meal amounts given by the 'pet-parent' and child-parent to obtain affection from the pet/child, which enables 'eating addiction' in the pet/child and results in parental 'co-dependence'. Pet-parents and child-parents may even become hostage to the treats/food to avoid the ire of the pet/child. Eating addiction in the pet/child also may be brought about by emotional factors such as stress, independent of parental co-dependence. An applicable treatment for child obesity has been trialled using classic addiction withdrawal/abstinence techniques, as well as behavioural addiction methods, with significant results. Both the child and the parent progress through withdrawal from specific 'problem foods', next from snacking (non-specific foods) and finally from excessive portions at meals (gradual reductions). This approach should adapt well for pets and pet-parents. Pet obesity is more 'pure' than child obesity, in that contributing factors and treatment points are essentially under the control of the pet-parent. Pet obesity might thus serve as an ideal test bed for the treatment and prevention of child obesity, with focus primarily on parental behaviours. Sharing information between the fields of pet and child obesity would be mutually beneficial.

  13. FDG PET and PET-CT for the detection of bone metastases in patients with head and neck cancer. A meta-analysis

    International Nuclear Information System (INIS)

    Yi, Xuelin; Zhang, Hongting; Liu, Shixi; Fan, Min; Liu, Yilin

    2013-01-01

    We performed a meta-analysis to evaluate 18FDG PET/PET-CT for the detection of bone metastases in patients with head and neck cancer. We calculated sensitivities, specificities, likelihood ratios, and constructed summary receiver operating characteristic curves for PET and PET-CT, respectively. We also compared the performance of PET/PET-CT with that of bone scintigraphy by analysing studies that had also used bone scintigraphy on the same patients. Across 9 PET studies (1621 patients) and 10 PET-CT studies (1291 patients), sensitivity and specificity of PET were 0.81 and 0.99, and of PET-CT were 0.89 and 0.99, respectively. In 5 comparative studies (1184 patients), sensitivity and specificity of PET/PET-CT were 0.85 and 0.98, and of bone scintigraphy were 0.55 and 0.98, respectively. 18FDG PET and PET-CT have high sensitivity and accuracy for the detection of bone metastasis in patients with head and neck cancer.

  14. Pets and Parasites

    Science.gov (United States)

    ... good news is that this rarely happens. Most pet-to-people diseases can be avoided by following a few ... your doctor Can a parasite cause death in people and pets? Can human disease from a parasite be treated ...

  15. Heart PET scan

    Science.gov (United States)

    ... nuclear medicine scan; Heart positron emission tomography; Myocardial PET scan ... A PET scan requires a small amount of radioactive material (tracer). This tracer is given through a vein (IV), ...

  16. [Principles of PET].

    Science.gov (United States)

    Beuthien-Baumann, B

    2018-05-01

    Positron emission tomography (PET) is a procedure in nuclear medicine, which is applied predominantly in oncological diagnostics. In the form of modern hybrid machines, such as PET computed tomography (PET/CT) and PET magnetic resonance imaging (PET/MRI) it has found wide acceptance and availability. The PET procedure is more than just another imaging technique, but a functional method with the capability for quantification in addition to the distribution pattern of the radiopharmaceutical, the results of which are used for therapeutic decisions. A profound knowledge of the principles of PET including the correct indications, patient preparation, and possible artifacts is mandatory for the correct interpretation of PET results.

  17. Preparing for Harvesting Radioisotopes from FRIB

    Energy Technology Data Exchange (ETDEWEB)

    Peaslee, Graham F. [Hope College, Holland, MI (United States); Lapi, Suzanne E. [Washington Univ., St. Louis, MO (United States)

    2015-02-02

    The Facility for Rare Isotope Beams (FRIB) is the next generation accelerator facility under construction at Michigan State University. FRIB will produce a wide variety of rare isotopes by a process called projectile fragmentation for a broad range of new experiments when it comes online in 2020. The accelerated rare isotope beams produced in this facility will be more intense than any current facility in the world - in many cases by more than 1000-fold. These beams will be available to the primary users of FRIB in order to do exciting new fundamental research with accelerated heavy ions. In the standard mode of operation, this will mean one radioisotope will be selected at a time for the user. However, the projectile fragmentation process also yields hundreds of other radioisotopes at these bombarding energies, and many of these rare isotopes are long-lived and could have practical applications in medicine, national security or the environment. This project developed new methods to collect these long-lived rare isotopes that are by-products of the standard FRIB operation. These isotopes are important to many areas of research, thus this project will have a broad impact in several scientific areas including medicine, environment and homeland security.

  18. Drying equipment for radioisotope-treated animals

    International Nuclear Information System (INIS)

    Fujikake, Toshio; Ohmori, Akira; Takada, Yukio; Nakano, Shozoh; Tamai, Shinsuke.

    1978-01-01

    The animal experiments using radioisotopes have been carried out over wide fields, accordingly, the number of radioisotope-contaminated animal cadavers has been increasing rapidly. It was decided that each establishment employing radioiosotopes dries those cadavers to such state as to be able to burn up with the device in Japan Atomic Energy Research Institute. The animal waste-drying device meeting the above mentioned purpose was developed by the joint work of Fuji Electric General Devices Co. and Fuji Electric Co. It is known as the micro-wave drying device for animals (its nickname is Microdry). This device dehydrates at high speed by micro-wave drying method. By using along with a moisture detector, it gives the drying state as requested regardless of the water content of each animal. The animal wastes after perfect dehydration are reduced to the weight of about one-third, and the dried animal cadavers can be preserved for a long time at room temperature because of the sterilizing effect of the micro-wave heating. This device is noted for its excellent safeness, simple operation, and low treatment cost. It is anticipated that it can be further applied to other fields such as excreta, breeding materials, etc. (Kobatake, H.)

  19. Safe Handling of Radioisotopes. Health Physics Addendum

    International Nuclear Information System (INIS)

    Appleton, G.J.; Krishnamoorthy, P.N.

    1960-01-01

    The International Atomic Energy Agency published in 1958 a Manual entitled ''Safe Handling of Radioisotopes'' (Safety Series No. 1 - STI/PUB/1), based on the work of an international panel convened by the Agency. As recommended by that panel and approved by the Agency's Board of Governors, this Addendum has now been prepared, primarily as a supplement to the Manual. It contains technical information necessary for the implementation of the controls given in the Manual. In addition, it is intended to serve as a brief introduction to the technical problems encountered in radiological protection work and to the methods of resolving them. As in the case of the Manual itself, the information given in this Addendum is particularly relevant to the problems encountered by the small user of radioisotopes. Although the basic principles set forth in it apply to all work with radiation sources, the Addendum is not intended to serve as a radiological protection manual for use in reactor installations or large-scale nuclear industry, where more specialized techniques and information are required.

  20. Medical research with radioisotopes in Greece

    Energy Technology Data Exchange (ETDEWEB)

    Belcher, E H [Post-graduate Medical School, Hammersmith, London (United Kingdom)

    1961-07-15

    An important program of research into the nature and causes of congenital haemolytic anaemias, notably the disease known as Mediterranean anaemia or Thalassaemia, which is a serious medical problem in the Mediterranean countries, is at present being carried out in the Department of Clinical Therapeutics of the University of Athens under a research contract awarded by the International Atomic Energy Agency. This program is concerned with diseases in which there is an inherited defect or abnormality in the production of haemoglobin, the iron-containing pigment of the red blood cells which is responsible for the carriage of oxygen in the blood. Two techniques have been widely used in the studies at the University of Athens. In the first of these, a radioisotope of iron, iron-59, is used to follow iron metabolism and haemoglobin production. Iron metabolism in the body is concerned largely with the synthesis and breakdown of haemoglobin, which consists of a protein, globin, linked to an iron containing substance, haeme. The second technique makes use of a radioisotope of chromium, chromium-51, to study the fate of the red cells in the blood. By performing simultaneous studies with iron- 59 and chromium-51, a detailed picture of haemoglobin synthesis and red cell production and destruction can be built up. Such investigations have been invaluable in establishing the characteristic patterns of different congenital haemolytic anaemias.

  1. Safe Handling of Radioisotopes. Health Physics Addendum

    Energy Technology Data Exchange (ETDEWEB)

    Appleton, G J; Krishnamoorthy, P N

    1960-07-15

    The International Atomic Energy Agency published in 1958 a Manual entitled ''Safe Handling of Radioisotopes'' (Safety Series No. 1 - STI/PUB/1), based on the work of an international panel convened by the Agency. As recommended by that panel and approved by the Agency's Board of Governors, this Addendum has now been prepared, primarily as a supplement to the Manual. It contains technical information necessary for the implementation of the controls given in the Manual. In addition, it is intended to serve as a brief introduction to the technical problems encountered in radiological protection work and to the methods of resolving them. As in the case of the Manual itself, the information given in this Addendum is particularly relevant to the problems encountered by the small user of radioisotopes. Although the basic principles set forth in it apply to all work with radiation sources, the Addendum is not intended to serve as a radiological protection manual for use in reactor installations or large-scale nuclear industry, where more specialized techniques and information are required.

  2. Radioisotopes produced by neutron irradiation of food

    International Nuclear Information System (INIS)

    Albright, S.; Seviour, R.

    2016-01-01

    The use of neutrons for cargo interrogation has the potential to drastically improve threat detection. Previous research has focussed on the production of "2"4Na, based on the isotopes produced in pharmaceuticals and medical devices. For both the total activity and the ingestion dose we show that a variety of isotopes contribute and that "2"4Na is only dominant under certain conditions. The composition of the foods has a strong influence on the resulting activity and ingestion dose suggesting that the pharmaceuticals and medical devices considered initially are not a viable analogue for foodstuffs. There is an energy dependence to the isotopes produced due to the cross-sections of different reactions varying with neutron energy. We show that this results in different isotopes dominating the ingestion dose at different energies, which has not been considered in the previous literature. - Highlights: • We show that neutron interrogation of food can produce many radioisotopes. • We show a strong dependance between food and certain radioisotopes. • Some isotopes are shown to have an energy dependence. • Previous claims that 24Na is the main threat is shown to only apply in special cases.

  3. Discrete radioisotopic relays of a cyclic action

    International Nuclear Information System (INIS)

    Klempner, K.S.; Vasil'ev, A.G.

    1975-01-01

    A functional diagram of discrete radioisotopic relay equipment (RRP) with cyclic action was examined. An analysis of its rapid action and reliability under stationary conditions and transition regimes is presented. A structural diagram of radioisotopic relay equipment shows three radiation detectors, a pulse standardizer, an integrator and a power amplifier with a threshold cut-off device. It was established that the basic properties of the RRP - rapid action and reliability - are determined entirely by the counting rate of the average frequency of pulses from the radiation detector, n 0 and n 1 , in the 0 and 1 states (absence of current in the electromagnetic relay winding and activation of the winding of the output relay), capacities N 1 and N 2 of the dual counters, and the frequency of the transition threshold, f, of the generator. Formulas are presented which allow making engineering calculations for determining the optimum RRP parameters. High speed and reliability are shown, which are determined by the production purposes of the relay

  4. Report of Radioisotope Inspection Technical Committee

    International Nuclear Information System (INIS)

    Otani, H.

    1980-01-01

    For the purpose of unifying the method of performance test for the routine management of the performance of RI equipments, the check-up of performance at the time of purchasing the equipments or research works, the Committee has continued the investigation on the method of performance test on RI equipments. Now, the definite plans have been decided regarding the method of performance test on radioisotope monitoring instruments and the measuring instruments for RI samples, therefore they are reported hereinafter. As for the radioisotope monitoring instruments, Curie meter, area monitor, water monitor, gas monitor and hand, foot and cloth monitor were taken up, and the items of inspection, the purposes, the testing methods, the expression of measured results and their evaluation were discussed. The accuracy of measurement of absolute radio-activity is important in Curie meter, the stability of continuous monitoring is important in general monitors, and the limit of measurement is important in the hand, foot and cloth monitor. As for the measuring instruments for radioactive materials, the efficiency of counting, linearity and stability were taken up as the items of performance test, and other matters to which attention should be paid were added. These were described, dividing into well type scintillation counter and liquid scintillation counter. (Kako, I.)

  5. Reliability Issues in Stirling Radioisotope Power Systems

    Science.gov (United States)

    Schreiber, Jeffrey; Shah, Ashwin

    2005-01-01

    Stirling power conversion is a potential candidate for use in a Radioisotope Power System (RPS) for space science missions because it offers a multifold increase in the conversion efficiency of heat to electric power and reduced requirement of radioactive material. Reliability of an RPS that utilizes Stirling power conversion technology is important in order to ascertain long term successful performance. Owing to long life time requirement (14 years), it is difficult to perform long-term tests that encompass all the uncertainties involved in the design variables of components and subsystems comprising the RPS. The requirement for uninterrupted performance reliability and related issues are discussed, and some of the critical areas of concern are identified. An overview of the current on-going efforts to understand component life, design variables at the component and system levels, and related sources and nature of uncertainties are also discussed. Current status of the 110 watt Stirling Radioisotope Generator (SRG110) reliability efforts is described. Additionally, an approach showing the use of past experience on other successfully used power systems to develop a reliability plan for the SRG110 design is outlined.

  6. Safe Handling of Radioisotopes. Medical Addendum

    International Nuclear Information System (INIS)

    Hercik, F.; Jammet, H.

    1960-01-01

    The International Atomic Energy Agency published in 1958 a Manual entitled ''Safe Handling of Radioisotopes'' (Safety Series No. 1 - STI/PUB/1), based on the work of an international panel convened by the Agency. As recommended by that panel and approved by the Agency's Board of Governors, this Addendum has now been prepared, primarily as a supplement to the Manual. It contains information necessary to medical officers concerned with the implementation of the controls given in the Manual. In addition, it is intended to serve as a brief introduction to the medical problems encountered in radiological protection work and to the methods of resolving them. As in the case of the Manual itself, the information given in this Addendum is particularly relevant to the problems encountered by the small user of radioisotopes. Although the basic principles set forth in it apply to all work with radiation sources, the Addendum is not intended to serve as a radiological protection manual for use in reactor installations or large-scale nuclear industry, where more specialized techniques and information are required.

  7. Diagnostic accuracy of 18F-FDG-PET and PET/CT in patients with Ewing sarcoma family tumours: a systematic review and a meta-analysis

    International Nuclear Information System (INIS)

    Treglia, Giorgio; Salsano, Marco; Stefanelli, Antonella; Mattoli, Maria Vittoria; Giordano, Alessandro; Bonomo, Lorenzo

    2012-01-01

    To systematically review and meta-analyse literature data on the diagnostic performance of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) in patients with Ewing sarcoma family tumours (ESFT). PubMed/MEDLINE, Embase and Scopus databases were searched for articles that evaluated FDG-PET and PET/CT in patients with ESFT from inception to 31 May 2011. Studies that fulfilled the three following criteria were included in the systematic review: FDG-PET or PET/CT performed in patients with ESFT; articles about the diagnostic accuracy of FDG-PET and PET/CT; sample size of at least 10 patients with ESFT were included. Studies in which there were sufficient data to reassess sensitivity and specificity of FDG-PET or PET/CT in ESFT were included in the meta-analysis, excluding duplicate publications. Finally, pooled sensitivity, pooled specificity and area under the receiver operating characteristic (ROC) curve of FDG-PET or PET/CT in ESFT were calculated. We found 13 studies comprising a total of 342 patients with ESFT. The main findings of the studies included are presented. The meta-analysis of five selected studies provided these results about FDG-PET and PET/CT in ESFT: pooled sensitivity: 96% (95% confidence interval [CI] 91-99%); pooled specificity: 92% (95% CI 87-96%); area under the ROC curve: 0.97. With regard to the staging and restaging of patients with ESFT, the sensitivity, specificity and accuracy of FDG-PET and PET/CT are high; the combination of FDG-PET or PET/CT with conventional imaging is a valuable tool for the staging and restaging of ESFT and has a relevant impact on the treatment strategy plan. (orig.)

  8. Diagnostic accuracy of {sup 18}F-FDG-PET and PET/CT in patients with Ewing sarcoma family tumours: a systematic review and a meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Treglia, Giorgio [Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Department of Bioimaging and Radiological Sciences, Rome (Italy); Institute of Nuclear Medicine, Positron Emission Tomography Centre, Catholic University of the Sacred Heart, Department of Bioimaging and Radiological Sciences, Rome (Italy); Salsano, Marco; Stefanelli, Antonella; Mattoli, Maria Vittoria; Giordano, Alessandro [Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Department of Bioimaging and Radiological Sciences, Rome (Italy); Bonomo, Lorenzo [Institute of Radiology, Catholic University of the Sacred Heart, Department of Bioimaging and Radiological Sciences, Rome (Italy)

    2012-03-15

    To systematically review and meta-analyse literature data on the diagnostic performance of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) in patients with Ewing sarcoma family tumours (ESFT). PubMed/MEDLINE, Embase and Scopus databases were searched for articles that evaluated FDG-PET and PET/CT in patients with ESFT from inception to 31 May 2011. Studies that fulfilled the three following criteria were included in the systematic review: FDG-PET or PET/CT performed in patients with ESFT; articles about the diagnostic accuracy of FDG-PET and PET/CT; sample size of at least 10 patients with ESFT were included. Studies in which there were sufficient data to reassess sensitivity and specificity of FDG-PET or PET/CT in ESFT were included in the meta-analysis, excluding duplicate publications. Finally, pooled sensitivity, pooled specificity and area under the receiver operating characteristic (ROC) curve of FDG-PET or PET/CT in ESFT were calculated. We found 13 studies comprising a total of 342 patients with ESFT. The main findings of the studies included are presented. The meta-analysis of five selected studies provided these results about FDG-PET and PET/CT in ESFT: pooled sensitivity: 96% (95% confidence interval [CI] 91-99%); pooled specificity: 92% (95% CI 87-96%); area under the ROC curve: 0.97. With regard to the staging and restaging of patients with ESFT, the sensitivity, specificity and accuracy of FDG-PET and PET/CT are high; the combination of FDG-PET or PET/CT with conventional imaging is a valuable tool for the staging and restaging of ESFT and has a relevant impact on the treatment strategy plan. (orig.)

  9. Actual and future situations of the use of radioisotopes

    International Nuclear Information System (INIS)

    Paredes G, L.C.

    2005-01-01

    It is anticipated to medium term, an increase in the demand of the radioisotopes for medicine, industry and research, as well as the application of new radioisotopes derived from the development of new radiopharmaceuticals products for diagnosis and therapy applications. The personal and clinical dosimetry will have to be prepared for the new challenges. (Author)

  10. A set of portable radioisotopic control and measuring instruments

    International Nuclear Information System (INIS)

    Pospeev, V.V.; Sidorov, V.N.; Tesnavs, Eh.R.; Uleksin, V.I.

    1979-01-01

    The problems and perspectives are examined of the portable radioisotope instruments application in agriculture, building industry, engeeniring and geological survay and in melioration. Principles are given of creation a series of radioisotopic instruments based on the principle of ganging. The series described consists of radioisotopic densimeters and moisture gages of the portable type, based on the ganging principle. The instruments differ in the measuring converters and have unified information processing and power supply devices. Criteria are stated for the ganging principle estimation, in particular, estimation of the technical means' compatibility. Four different types of compatibility are distinguished: an information compatibility; a metrological compatibility; structural and operational compatibility. Description is given of the unified information processing device - the unified pulse counter of the SIP-1M type and description of a row of radioisotopic measuring converters, which provides a possibility for completing the portable radioisotope densimeter of the RPP-2 type, intended for measuring densities of concrets and soils in the surface layer up to 30 cm and the density range from 1000 to 2500 kg/m 3 ; portable radioisotope densimeter of the RPP-1 type having measuring range from 600 to 1500 kg/m 3 ; surface-depth radioisotopic densimeter of the PPGR-1 type and surface-depth radioisotopic moisture gage of the VPGR-1 type [ru

  11. Application of radioisotope technique for investigation of pumps seals

    International Nuclear Information System (INIS)

    Antoszewski, B.; Zorawska, A.

    1988-01-01

    Radioisotope method of measuring the wear of rings of the face mechanical seals, bush in soft seals, and leakage in double mechanical seals is described. The examples are given. It is found that radioisotope technique can be used for investigation of the seals. (author)

  12. Shielded radioisotope generator and method for using same

    International Nuclear Information System (INIS)

    Fries, B.A.

    1976-01-01

    A nuclide generator for on-site radioisotope generation is disclosed in which the formation of a short-lived daughter radioisotope from its longer-lived parent features batch flow of eluting reagent interior of the generator in a completely shielded environment

  13. PET-Tool: a software suite for comprehensive processing and managing of Paired-End diTag (PET sequence data

    Directory of Open Access Journals (Sweden)

    Wei Chia-Lin

    2006-08-01

    Full Text Available Abstract Background We recently developed the Paired End diTag (PET strategy for efficient characterization of mammalian transcriptomes and genomes. The paired end nature of short PET sequences derived from long DNA fragments raised a new set of bioinformatics challenges, including how to extract PETs from raw sequence reads, and correctly yet efficiently map PETs to reference genome sequences. To accommodate and streamline data analysis of the large volume PET sequences generated from each PET experiment, an automated PET data process pipeline is desirable. Results We designed an integrated computation program package, PET-Tool, to automatically process PET sequences and map them to the genome sequences. The Tool was implemented as a web-based application composed of four modules: the Extractor module for PET extraction; the Examiner module for analytic evaluation of PET sequence quality; the Mapper module for locating PET sequences in the genome sequences; and the ProjectManager module for data organization. The performance of PET-Tool was evaluated through the analyses of 2.7 million PET sequences. It was demonstrated that PET-Tool is accurate and efficient in extracting PET sequences and removing artifacts from large volume dataset. Using optimized mapping criteria, over 70% of quality PET sequences were mapped specifically to the genome sequences. With a 2.4 GHz LINUX machine, it takes approximately six hours to process one million PETs from extraction to mapping. Conclusion The speed, accuracy, and comprehensiveness have proved that PET-Tool is an important and useful component in PET experiments, and can be extended to accommodate other related analyses of paired-end sequences. The Tool also provides user-friendly functions for data quality check and system for multi-layer data management.

  14. Assessment of radioisotope heaters for remote terrestrial applications

    International Nuclear Information System (INIS)

    Uherka, K.L.

    1987-05-01

    This paper examines the feasibility of using radioisotope byproducts for special heating applications at remote sites in Alaska and other cold regions. The investigation included assessment of candidate radioisotope materials for heater applications, identification of the most promising cold region applications, evaluation of key technical issues and implementation constraints, and development of conceptual heater designs for candidate applications. Strontium-90 (Sr-90) was selected as the most viable fuel for radioisotopic heaters used in terrestrial applications. Opportunities for the application of radioisotopic heaters were determined through site visits to representative Alaska installations. Candidate heater applications included water storage tanks, sludge digesters, sewage lagoons, water piping systems, well-head pumping stations, emergency shelters, and fuel storage tank deicers. Radioisotopic heaters for water storage tank freeze-up protection and for enhancement of biological waste treatment processes at remote sites were selected as the most promising applications

  15. Synthesis of stereo (R and S) and geometric (E and Z) [F-18]fluoro-β-fluoromethylene-M-tyrosine derivatives: specific PET probes for central dopamine systems

    International Nuclear Information System (INIS)

    Lacan, G.; Barrio, J.R.; Satyamurthy, N.; Yu, D.C.; Huang, S.C.; Phelps, M.E.

    1994-01-01

    Racemic β-fluoromethylene-m-tyrosine (FMMl) was developed as an aromatic amino acid decarboxylase (AAAD)- activated monoamine oxidase (MAO) suicide inhibitor. Direct [F-18] fluorination of pure enantiomers, R and S-(E)-β- fluoromethylene-m-tyrosine (E-FMMT) and the racemic geometric isomer R,S(Z)-β-fluoromethylene-m-tyrosine (Z-FMMT) with [F- 18] acetylhypofluorite, afforded 6- and 2[F-18] fluoro positional isomers as the major products. Regioselective radiofluorodestannylation of the respective 4-trimethylstannyl R,S- (E) - FMMT with [F-18]F 2 yielded the 4[F-18] fluoro derivative, thus allowing for the systematic evaluation of the regio- and stereo radiofluorinated AAAD probes. Macacca nemestrina monkeys were injected iv with purified radiofluorinated FMMT analogs and the distribution of activity in the central dopaminergic system was studied with positron emission tomography (PET). Radiofluorinated stereo and geometric FMMT derivatives showed significant differences in their in vivo striatal localization, with radioprobe localization decreasing in the order: 6F-S-(E)-FMMT >> 2F-S-(E)- FMMT >> 4F-R,S-(E)-FMMT. Neither radiofluorinated analogs of R-(E)- FMMT and R,S-(Z)-FMMT showed any significant striatal localization in vivo. (author)

  16. FDG-PET and FDG-PET/CT for therapy monitoring and restaging in malignant lymphoma

    International Nuclear Information System (INIS)

    Mottaghy, F.M.; Krause, B.J.

    2003-01-01

    F-18-fluorodeoxyglucose (FDG) PET allows to assess residual masses in patients with malignant lymphoma differentiating vital tumor from scar tissue. This approach is not applicable with conventional imaging methods (CDM) such as CT or MRI. On the other hand circumscribed results often cannot be definitely allocated in PET, therefore the combined morphological-biochemical approach using the now available PET/CT systems promises to be a pathbreaking technical progress. There is no doubt that stand alone PET is superior to CDM differentiating residual scar tissue from vital tumor as has been shown in 15 recently published studies. The median sensitivity for detecting active disease with FDG PET across the studies was 91%; the corresponding specificity was 89%. As a result FDG PET had a high negative predictive value of 94%. In contrast, specificity and positive predictive value (PPV) of CDM in the 9 studies were a direct comparison was available were low (31% and 46%, one study 82%). PET positive residual masses were associated with a progression-free survival of 0 - 55%. Only a few studies have included FDG-PET in therapy response monitoring studies, however also these results are promising. At the moment FDG-PET seems to be the best possibility to characterize and qualitatively visualize vitality of tumor masses and also hold promises for efficient therapy response monitoring in patients with malignant lymphoma. Therefore it should be included in standard diagnostic protocols in lymphoma patients. The combined PET/CT has to be ranked superior to conventional PET studies as in many cases the combined structural and functional imaging brings a clearer diagnostic statement. (orig.) [de

  17. Medical Radioisotope Scanning, Vol. II. Proceedings of the Symposium on Medical Radioisotope Scanning

    International Nuclear Information System (INIS)

    1964-01-01

    Medical applications of radioisotopes continue to grow in number and importance and medical centres in almost all countries of the world are now using radioactive materials both in the diagnosis and treatment of disease. An increasing proportion of these applications involves studies of the spatial distribution of radioactive material within the human body, for which purpose highly specialized scanning methods have been elaborated. By these methods it is possible to study the position, size and functional state of different organs, to detect tumours, cysts and other abnormalities and to obtain much useful information about regions of the body that are otherwise inaccessible, except by surgery. Progress in scanning methods in recent years has been very rapid and there have been many important advances in instrumentation and technique. The development of new forms of the gamma camera and of colour-scanning techniques are but two examples of recent improvements. The production of new radioisotopes and new labelled compounds has further extended the scope of these methods. To survey these new advances the International Atomic Energy Agency held a Symposium on Medical Radioisotope Scanning in Athens from 20-24 April 1964. The scientific programme of the meeting covered all aspects of scanning methods including theoretical principles, instrumentation, techniques and clinical applications. The World Health Organization assisted in the selection of papers by providing a consultant to the selection committee. The meeting followed the earlier IAEA/WHO Seminar on Medical Radioisotope Scanning in Vienna in 1959, which was attended by 36 participants and at which 14 papers were presented. Some idea of the growth of interest in the subject may be gained from the fact that the Symposium was attended by 160 participants from 26 countries and 4 international organizations, and that 58 papers were presented. The published proceedings, comprising two volumes, contain all the

  18. PET/MRI: Technical challenges and recent advances

    International Nuclear Information System (INIS)

    Jung, Jin Ho; Choi, Yong; Im, Ki Chun

    2016-01-01

    Integrated positron emission tomography (PET)/magnetic resonance imaging (MRI), which can provide complementary functional and anatomical information about a specific organ or body system at the molecular level, has become a powerful imaging modality to understand the molecular biology details, disease mechanisms, and pharmacokinetics in animals and humans. Although the first experiment on the PET/MRI was performed in the early 1990s, its clinical application was accomplished in recent years because there were various technical challenges in integrating PET and MRI in a single system with minimum mutual interference between PET and MRI. This paper presents the technical challenges and recent advances in combining PET and MRI along with several approaches for improving PET image quality of the PET/MRI hybrid imaging system

  19. FDG-PET/CT in oncology. German guideline

    International Nuclear Information System (INIS)

    Krause, B.J.; Beyer, T.; Bockisch, A.; Delbeke, D.; Kotzerke, J.; Minkov, V.; Reiser, M.; Willich, N.

    2007-01-01

    FDG-PET/CT examinations combine metabolic and morphologic imaging within an integrated procedure. Over the past decade PET/CT imaging has gained wide clinical acceptance in the field of oncology. This FDG-PET/CT guideline focuses on indications, data acquisition and processing as well as documentation of FDG-PET/CT examinations in oncologic patients within a clinical and social context specific to Germany. Background information and definitions are followed by examples of clinical and research applications of FDG-PET/CT. Furthermore, protocols for CT scanning (low dose and contrast-enhanced CT) and PET emission imaging are discussed. Documentation and reporting of examinations are specified. Image interpretation criteria and sources of errors are discussed. Quality control for FDG and PET/CT-systems, qualification requirements of personnel as well as legal aspects are presented. (orig.)

  20. SPECT and PET imaging in epilepsia

    International Nuclear Information System (INIS)

    Landvogt, C.

    2007-01-01

    In preoperative localisation of epileptogenic foci, nuclear medicine diagnostics plays a crucial role. FDG-PET is used as first line diagnostics. In case of inconsistent MRI, EEG and FDG-PET findings, 11 C-Flumazenil-PET or ictal and interictal perfusion-SPECT should be performed. Other than FDG, Flumazenil can help to identify the extend of the region, which should be resected. To enhance sensitivity and specificity, further data analysis using voxelbased statistical analyses or SISCOM (substraction ictal SPECT coregistered MRI) should be performed

  1. Notification determining details of technical standards concerning transport of radioisotopes or goods contaminated by radioisotopes outside works or enterprises

    International Nuclear Information System (INIS)

    1981-01-01

    This rule is established under the provisions of the regulation for the execution of the law on the prevention of radiation injuries by radioisotopes. Terms are used in this rule for the same meanings as in the regulation. The concentration of radioisotopes to which the technical standards for transport outside enterprises are not applied is 0.002 micro-curie per gram. The radioisotopes which can be transported as L type transported goods are defined in detail, excluding explosive or spontaneously igniting radioisotopes. The quantity limit of radioisotopes which can be transported as A type transported goods is the values A 1 and A 2 defined in this rule. The permissible surface density defined by the Director General of the Science and Technology Agency are 1/100,000 micro-curie per cm 2 for the radioisotopes emitting alpha-ray, and 1/10,000 micro-curie per cm 2 for the radioisotopes which do not emit alpha-ray. The leak quantity of radioisotopes specified by the Director General is 1/1,000,000 of A 2 value for BM type transported goods and 1/1,000 of A 2 value for BU type goods. The test conditions for each type of transported goods, dangerous goods, the limit of the number of transported goods and signs are stipulated, respectively. Permissible exposure dose is 1.5 rem a year for persons other than radiation workers. (Okada, K.)

  2. Integro-differential equation analysis and radioisotope imaging systems. Research proposal. [Testing of radioisotope imaging system in phantoms

    Energy Technology Data Exchange (ETDEWEB)

    Hart, H.

    1976-03-09

    Design modifications of a five-probe focusing collimator coincidence radioisotope scanning system are described. Clinical applications of the system were tested in phantoms using radioisotopes with short biological half-lives, including /sup 75/Se, /sup 192/Ir, /sup 43/K, /sup 130/I, and /sup 82/Br. Data processing methods are also described. (CH)

  3. Radioisotope thermal photovoltaic application of the GaSb solar cell

    Science.gov (United States)

    Morgan, M. D.; Horne, W. E.; Day, A. C.

    1991-01-01

    An examination of a RTVP (radioisotopic thermophotovoltaic) conceptual design has shown a high potential for power densities well above those achievable with radioisotopic thermoelectric generator (RTG) systems. An efficiency of 14.4 percent and system specific power of 9.25 watts/kg were predicted for a system with sixteen GPHS (general purpose heat source) sources operating at 1100 C. The models also showed a 500 watt system power by the strontium-90 isotope at 1200 C at an efficiency of 17.0 percent and a system specific power of 11.8 watts/kg. The key to this level of performance is a high-quality photovoltaic cell with narrow bandgap and a reflective rear contact. Recent work at Boeing on GaSb cells and transparent back GaAs cells indicate that such a cell is well within reach.

  4. PET with a dual-head coincidence gamma camera in head and neck cancer: A comparison with computed tomography and dedicated PET

    International Nuclear Information System (INIS)

    Zimny, M.

    2001-01-01

    Positron emission tomography with 18 F-fluoro-deoxyglucose (FDG PET) is a promising imaging tool for detecting and staging of primary or recurrent head and neck cancer. The aim of this study was to evaluate a dual-head gamma camera modified for coincidence detection (KGK-PET) in comparison to computed tomography (CT) and dedicated PET (dPET). 50 patients with known or suspected primary or recurrent head and neck cancer were enrolled. 32 patients underwent KGK-PET and dPET using a one-day protocol. The sensitivity for the detection of primary/ recurrent head and neck cancer for KGK-PET and CT was 80% and 54%, respectively, specificity was 73% and 82%, respectively. The sensitivity and specificity for the detection of lymph node metastases based on neck sides with KGK-PET was 71% (CT: 65%) and 88% (CT: 89%) respectively. In comparison to dPET, KGK-PET revealed concordant results in 32/32 patients with respect to primary tumor/recurrent disease and in 55/60 evaluated neck sides. All involved neck sides that were missed by KGK-PET were also negative with dPET. These results indicate that in patients with head and neck cancer KGK-PET reveals information, that are similar to dPET and complementary to CT. (orig.) [de

  5. PET in management of breast cancer

    International Nuclear Information System (INIS)

    Lee, Myung-Chul

    2004-01-01

    Full text: PET provides useful information about tumor metabolism enabling accurate visualization of malignant lesions. Approximately 60-80% suspicious lesions on mammography have benign histology and about 10% of breast cancers with palpable mass are not identified in mammography. The key roles of PET technology in breast cancer are in: primary diagnosis, staging, recurrent diseases monitoring and prediction of therapy response. The sensitivity and specificity of FDG-PET for the diagnosis of breast cancer has been reported to be 68-100% and 83-100%, respectively. Considering the increasing number of small breast tumors detected by mammography and false negative results, the clinical relevance of FDG-PET for the primary diagnosis is limited. In selected patients, however, for example with dense breasts, breasts implants, augmented breast or after breast surgery, which can affect the accuracy of mammography, and in cases with equivocal mammography, FDG-PET can provide clinically relevant information. PET accurately determines the extent of disease, including the loco-regional lymph node status. Furthermore, whole-body PET imaging promises a high diagnostic accuracy for detecting recurrent or metastatic breast carcinoma with a high positive predictive value. We studied the usefulness of the FDG-PET in 42 preoperative patients with suspected breast cancer in differentiation of lesions. The diagnostic value of FDG-PET in terms of sensitivity and specificity was 95% and 77% respectively in primary mass while it was 73% and 100% for axillary lymph nodes. PET is much more accurate than other conventional modalities. The sensitivity of FDG-PET for correct staging of axillary nodal status is 84-100%. It has the potential to replace conventional procedures for the staging of distant metastases. We observed the sensitivity and the specificity of FDG-PET to be 96% and 85% to detect distant metastases. FDG-PET may become the method of choice for the early assessment of

  6. Role of FDG-PET and PET/CT in the diagnosis and management of vasculitis

    Energy Technology Data Exchange (ETDEWEB)

    Zerizer, Imene; Tan, Kathryn; Khan, Sameer; Barwick, Tara [Department of Nuclear Medicine, Imperial College Healthcare, Hammersmith Hospital, Du Cane Road, London (United Kingdom); Marzola, Maria Cristina [Department of Nuclear Medicine, PET/CT Centre, Radiology and Medical Physics, ' Santa Maria della Misericordia' Hospital, Rovigo (Italy); Rubello, Domenico [Department of Nuclear Medicine, PET/CT Centre, Radiology and Medical Physics, ' Santa Maria della Misericordia' Hospital, Rovigo (Italy)], E-mail: domenico.rubello@libero.it; Al-Nahhas, Adil [Department of Nuclear Medicine, Imperial College Healthcare, Hammersmith Hospital, Du Cane Road, London (United Kingdom)

    2010-03-15

    Purpose: to investigate the role of FDG-PET and PET/CT in the evaluation of vasculitis. Materials and methods: a systematic revision of the papers published in PubMed/Medline until December 2009 was done. Results: FDG-PET and PET/CT have been proven to be valuable in the diagnosis of large-vessel vasculitis, especially giant cells arteritis with sensitivity values ranging 77% to 92%, and specificity values ranging 89% to 100%. In particular, FDG-PET/CT has demonstrated the potential to non-invasively diagnose the onset of the vasculitis earlier than traditional anatomical imaging techniques, thus enabling prompt treatment. False positive results mainly occur in the differential diagnosis between vasculitis and atherosclerotic vessels in elderly patients. Another area where FDG-PET/CT is gaining wider acceptance is in monitoring response to therapy; it can reliably detect the earliest changes of disease improvement post-therapy, and persistent activity is an indicator of non-responders to therapy. A few data have been reported about medium/small vessel vasculitis. Discussion: FDG-PET and PET/CT have proven utility: (a) in the initial diagnosis of patients suspected of having vasculitis particularly in those who present with non-specific symptoms; (b) in the identification of areas of increased FDG uptake in which a biopsy should be done for obtaining a diagnosis; (c) in evaluating the extent of the disease; (d) in assessing response to treatment.

  7. Role of FDG-PET and PET/CT in the diagnosis and management of vasculitis

    International Nuclear Information System (INIS)

    Zerizer, Imene; Tan, Kathryn; Khan, Sameer; Barwick, Tara; Marzola, Maria Cristina; Rubello, Domenico; Al-Nahhas, Adil

    2010-01-01

    Purpose: to investigate the role of FDG-PET and PET/CT in the evaluation of vasculitis. Materials and methods: a systematic revision of the papers published in PubMed/Medline until December 2009 was done. Results: FDG-PET and PET/CT have been proven to be valuable in the diagnosis of large-vessel vasculitis, especially giant cells arteritis with sensitivity values ranging 77% to 92%, and specificity values ranging 89% to 100%. In particular, FDG-PET/CT has demonstrated the potential to non-invasively diagnose the onset of the vasculitis earlier than traditional anatomical imaging techniques, thus enabling prompt treatment. False positive results mainly occur in the differential diagnosis between vasculitis and atherosclerotic vessels in elderly patients. Another area where FDG-PET/CT is gaining wider acceptance is in monitoring response to therapy; it can reliably detect the earliest changes of disease improvement post-therapy, and persistent activity is an indicator of non-responders to therapy. A few data have been reported about medium/small vessel vasculitis. Discussion: FDG-PET and PET/CT have proven utility: (a) in the initial diagnosis of patients suspected of having vasculitis particularly in those who present with non-specific symptoms; (b) in the identification of areas of increased FDG uptake in which a biopsy should be done for obtaining a diagnosis; (c) in evaluating the extent of the disease; (d) in assessing response to treatment.

  8. Supercritical CO{sub 2} fluid radiochromatography system used to purify [{sup 11}C]toluene for PET

    Energy Technology Data Exchange (ETDEWEB)

    Muller, Ryan D.; Ferrieri, Richard A. E-mail: rferrieri@bnl.gov; Gerasimov, Madina; Garza, Victor

    2002-04-01

    Abuse of inhalants in today's society has become such a widespread problem among today's adolescents that in many parts of the world their use exceeds that of many other illicit drugs or alcohol. Even so, little is known how such inhalants affect brain function to an extent that can lead to an abuse liability. While methodologies exist for radiolabeling certain inhalants of interest with short-lived positron emitting radioisotopes that would allow their investigation in human subjects using positron emission tomography (PET), the purification methodologies necessary to separate these volatile substances from the organic starting materials have not been developed. We've adapted supercritical fluid technology to this specific PET application by building a preparative-scale supercritical CO{sub 2} fluid radiochromatograph, and applied it to the purification of [{sup 11}C]toluene. We've demonstrated that [{sup 11}C]toluene can be separated from the starting materials using a conventional C{sub 18} HPLC column and pure supercritical CO{sub 2} fluid as the mobile phase operating at 2000 psi and 40 deg. C. We've also shown that the purified radiotracer can be quantitatively captured on Tenax GR, a solid support material, as it exits the supercritical fluid stream, thus allowing for later desorption into a 1.5% cyclodextrin solution that is suitable for human injection, or into a breathing tube for direct inhalation.

  9. The FDG-PET diagnosis of head and neck malignant tumor

    International Nuclear Information System (INIS)

    Kada, Shinpei; Hayashi, Masahiko; Okazawa, Hidehiko

    2003-01-01

    We investigated the utility of whole body FDG-PET in patients with head and neck malignant tumor, retrospectively. Fifty four FDG-PET studies were performed in 45 patients. Regarding the primary tumor and nodal metastasis, we compared the diagnosis of only FDG-PET with diagnosis using CT, MRI, and physical examination without FDG-PET (diagnosis without FDG-PET). These FDG-PET images were evaluated with visual interpretation qualitatively. At the primary tumor, sensitivity and specificity of FDG-PET diagnoses were 90% and 93%, and those of the diagnoses without FDG-PET were 95% and 100%, respectively; for nodal metastasis, sensitivity and specificity of FDG-PET diagnoses were 90% and 84%, and those of the diagnoses without FDG-PET were 72% and 80%, respectively. In nodal metastasis, the diagnosis of FDG-PET was superior to the diagnosis without FDG-PET. However, it is important to be careful of false positive findings of FDG-PET such as inflammatory lymph nodes, and false negative findings such as very thin tumors. By combining the FDG-PET diagnosis with other examinations, we could achieve almost perfect diagnosis. Farthermore, we perform FDG-PET repeatedly to improve diagnosis accuracy. (author)

  10. FDG PET imaging dementia

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Byeong Cheol [Kyungpook National University Medical School and Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2007-04-15

    Dementia is a major burden for many countries including South Korea, where life expectancy is continuously growing and the proportion of aged people is rapidly growing. Neurodegenerative disorders, such as, Alzheimer disease, dementia with Lewy bodies, frontotemporal dementia. Parkinson disease, progressive supranuclear palsy, corticobasal degeneration, Huntington disease, can cause dementia, and cerebrovascular disease also can cause dementia. Depression or hypothyroidism also can cause cognitive deficits, but they are reversible by management of underlying cause unlike the forementioned dementias. Therefore these are called pseudodementia. We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new drugs postpone progression of dementias or target specific proteins that cause dementia. Efficient pharmacologic treatment of dementia needs not only to distinguish underlying causes of dementia but also to be installed as soon as possible. Therefore, differential diagnosis and early diagnosis of dementia are utmost importance. F-18 FDG PET is useful for clarifying dementing diseases and is also useful for early detection of the disease. Purpose of this article is to review the current value of FDG PET for dementing diseases including differential diagnosis of dementia and prediction of evolving dementia.

  11. FDG PET imaging dementia

    International Nuclear Information System (INIS)

    Ahn, Byeong Cheol

    2007-01-01

    Dementia is a major burden for many countries including South Korea, where life expectancy is continuously growing and the proportion of aged people is rapidly growing. Neurodegenerative disorders, such as, Alzheimer disease, dementia with Lewy bodies, frontotemporal dementia. Parkinson disease, progressive supranuclear palsy, corticobasal degeneration, Huntington disease, can cause dementia, and cerebrovascular disease also can cause dementia. Depression or hypothyroidism also can cause cognitive deficits, but they are reversible by management of underlying cause unlike the forementioned dementias. Therefore these are called pseudodementia. We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new drugs postpone progression of dementias or target specific proteins that cause dementia. Efficient pharmacologic treatment of dementia needs not only to distinguish underlying causes of dementia but also to be installed as soon as possible. Therefore, differential diagnosis and early diagnosis of dementia are utmost importance. F-18 FDG PET is useful for clarifying dementing diseases and is also useful for early detection of the disease. Purpose of this article is to review the current value of FDG PET for dementing diseases including differential diagnosis of dementia and prediction of evolving dementia

  12. Not only PET for oncological disorders

    International Nuclear Information System (INIS)

    Soroa, V.E.; victoriasoroa@fibertel. com.ar; Velasques Espeche, M. del H.; Garcia, Luis M.

    2004-01-01

    suppliers. Tc-99m somatostatin receptor imaging being the first radiopharmaceutical labeled in CNEA laboratories came promptly in use, thanks to the availability of the radioisotope label. SPECT imaging is required for both radiopharmaceuticals to identify pathologies such as: thyroid C-cell, gastro-intestinal, paraganglioma, pituitary adenomas, pancreas islet cells, adrenal medulla, pheochromocytoma and lung oat cell cancer. Neurosurgeons at our University Hospital send their patients to obtain an answer if the patient has a tumor growth. Early (10-20 min.) Tc-99m Sestamibi SPECT as compared to 2-hrs. late SPECT imaging is able to give highly accurate answer in 92-95% of the studied cases (20 patients). Internists frequently send oncological patients with fever of unknown origin to detect infection/inflammation conditions or to confirm if it is due to tumor growth or cytostatic treatment. The frequency of the request is higher when the patients have a clinical history of prosthetic materials, multiple cysts, recent surgery or urinary tract infections. Specific infection /inflammation radiopharmaceuticals should be used for scanning early and late 24-hr. images. We have studied a population of 60 patients under these circumstances. In vitro labeled 99mTc homologous leucocytes, 99mTc-antibiotics and 99mTcpolyclonal immunoglobulin were the most frequently used specific markers employed to get an answer in such patients. Nuclear medicine procedures like Tc-99m MUGA also help in monitoring of patients on cardio toxic medication like chemotherapeutic agents. The review of patients imaged for diagnosis, follow-up and prognostication shows that planar and SPECT imaging in oncology is cost-effective and provide significant information for patient management. (author)

  13. Study on application of radiation and radioisotopes -Development of the radioisotope production facilities for the HANARO

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ji Bok; Woo, Jong Sub; Kang, Byung Woi; Baek, Sam Tae; Jeong, Un Soo; Park, Yong Chul; Jeon, Young Keon; Chang, Chun Ik; Lee, Bong Jae [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-08-01

    Development and construction of the lead hot cell for radioisotope production and related facility. 1. Fabrication and installation of the lead H/C system. 2. Development and installation of the hydraulic transfer system. 3. Development of the radiation monitoring system. 4. Fabrication and installation of the fire extinguishing system in the H/C. 5. Fabrication and installation of the fume hood. 4 tabs.,10 figs. (Author).

  14. 82Sr--82Rb radioisotope generator

    International Nuclear Information System (INIS)

    Grant, P.M.; Erdal, B.R.; O'Brien, H.A.

    1976-01-01

    An improved 82 Sr- 82 Rb radioisotope generator system, based upon the complexing ion exchange resin Chelex-100, has been developed. Columns of this material can be easily and rapidly milked, and the Rb-Sr separation factor for a fresh generator was found to be greater than 10 7 . Approximately 80 percent of the 82 Rb present was delivered in a 15-ml volume of aqueous 0.2 M NH 4 Cl solution. After more than 6 liters of eluant had been put through the generator, the Rb-Sr separation factor was still observed to be greater than 10 5 , and no unusual strontium breakthrough behavior was seen in the system over nearly three 82 Sr half lives. 2 claims, no drawings

  15. Radioisotope heaters for spacecraft life support systems

    International Nuclear Information System (INIS)

    Shivers, R.W.; Murray, R.W.

    1974-01-01

    Future manned space flight requires the sanitary collection and disposal of biological wastes to minimize microbial contamination hazard. The recovery and reuse of water from such wastes are also necessary to reduce the weight of vehicles at launching and resupply logistics. The development and test of an engineering model, i.e. the completely integrated waste management-water system using radioisotopes for thermal energy, are described. This is capable of collecting and processing the wastes from four men during 180-day simulated space mission. The sub-systems include collection of feces, trash and urine, water reclamation, the storage, heating and dispensing of the water, and the disposal of feces, urine residue and other non-metallic waste material by incineration. (Mori, K.)

  16. Microbiological quality control practices at Australian Radioisotopes

    International Nuclear Information System (INIS)

    Saunders, M.

    1987-01-01

    As a domestic manufacturer of therapeutic substances, Australian Radioisotopes (ARI) must adhere to guidelines set out by the Commonwealth Department of Health in the Code of Good Manufacturing Practices for Therapeutic Goods 1983 (GMP). The GMP gives guidelines for staff training, building requirements, sanitation, documentation and quality control practices. These guidelines form the basis for regular audits performed by officers of the National Biological Standards Laboratories. At Lucas Heights, ARI has combined the principles of the GMP with the overriding precautions introduced for environmental and staff safety and protection. Its policy is to maintain a high level of quality assurance for product identity, purity and sterility and apyrogenicity during all stages of product manufacture

  17. Radio-isotope powered light source

    International Nuclear Information System (INIS)

    Spottiswoode, N.L.; Ryden, D.J.

    1979-01-01

    The light source described comprises a radioisotope fuel source, thermal insulation against heat loss, a biological shield against the escape of ionizing radiation and a material having a surface which attains incandescence when subject to isotope decay heat. There is then a means for transferring this heat to produce incandescence of the surface and thus emit light. A filter associated with the surface permits a relatively high transmission of visible radiation but has a relatively high reflectance in the infra red spectrum. Such light sources require the minimum of attention and servicing and are therefore suitable for use in navigational aids such as lighthouses and lighted buoys. The isotope fuel sources and thus the insulation and shielding and the incandescent material can be chosen for the use required and several sources, materials, means of housing etc. are detailed. Operation and efficiency are discussed. (U.K.)

  18. Radioisotope production and distribution in Australia

    International Nuclear Information System (INIS)

    Brough, J.

    1986-01-01

    The high quality of radioactive products and services, provided by the Commercial Products Unit of Australian Atomic Energy Agency for industrial and medical applications are discussed. The production program has changed from research driven to being market driven. The Commission in fact not only manufactures radioisotopes and radiopharmaceuticals but also acts as a Centralized Dispensing Service for over sea products. The advantages associated with centralize distribution are discussed. The delivery arrangements and the existed problems are explained. With the unique experience, assistance and advice are provided for many years now to Nuclear Energy Unit at PUSPATI via staff training programs and many visits by the Commission staff to assist in the commissioning of the facilities in which enables PUSPATI to provide Malaysia and surrounding neighbour countries (on a smaller scale) with the similar type of service that the Commission does within Australia. (A.J.)

  19. Radioisotopes labelled agrochemicals for fertiliser development

    International Nuclear Information System (INIS)

    Cherian, S.; Subramanian, T.K.; Aachari, P.S.; Murthy, T.S.

    1979-01-01

    Chemical fertilisers like superphosphate, urea, ammonium phosphate, etc., are extensively used in agriculture for improving yields of various crops. Agrochemicals labelled with radioisotopes help in evaluating the fertiliser uptake and the role of essential nutrients like phosphorus, nitrogen and calcium in different types of soils. Such studies help the industry considerably in preparing fertilisers suitable for various crops and soil conditions. Methods have been developed for the large scale preparation of labelled fertilisers like superphosphate- 32 P, nitric phosphate- 32 P with varying water solubilities. An account of the experimental investigations carried out and the finalised procedures for the preparation of labelled agrochemicals are given. The chemical methods developed would be suitable for production of fertilisers using raw materials indigenously available. (auth.)

  20. Recent progress in development of radioisotope production

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Byung Mok [HANARO Center, Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1998-10-01

    The Korea multipurpose research reactor, HANARO(Hi-flux Advanced Neutron Application Reactor) is designed and constructed to obtain high density neutron flux (max. 5x10{sup 14} n/cm{sup 2}{center_dot}sec) with relatively low thermal output (30 MW) in order to utilize for various studies such as fuel and material test, radioisotope production, neutron activation analysis, neutron beam experiment, neutron transmutation doping, etc. HANARO has 32 vertical channels (3 in-core, 4 out-core, 25 reflector) and 7 horizontal channels. KAERI has constructed 4 concrete hot cells for production of Co-60, Ir-192, etc. and 6 lead hot cells for production of medical RIs(I-131, Mo-99, etc.). Other 11 lead hot cells will be completed by Feb. 1998 for production of Sm-153, Dy-165, Ho-166, etc. Clean room facilities were installed for production of radiopharmaceuticals. (author)

  1. Production of radioisotopes for medical use

    International Nuclear Information System (INIS)

    Ido, Tatsuo

    1977-01-01

    As problems in the process of production of short-lived radioisotopes for medical use and in clinical application of them, the following three items were mentioned: 1. separation and purification in a short time, 2. devices to decrease exposure dose in workers, and 3. preservation of radiochemical purity and chemical purity, and avoidance of mixture of impurities. In consideration of these problems, an outline of on-line production system of radioactive gases (from irradiation by accelerated particles to separation, purification, and administration of them), which was exploited in National Institute of Radiological Sciences, was described. Production of 13 NH 3 , the aqueous solution of 18 F, and 123 I was also given an outline. Simultaneous production method of many nuclides by means of laminated target and compounds labelled with positron emitter were also described. (Tsunoda, M.)

  2. Training in radioisotope uses for agricultural investigations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1966-12-15

    Full text: Seventeen students from Cambodia, the Republic of China, India, Israel, Pakistan, the Philippines, Syria, Thailand and the United Arab Republic attended an inter-regional training course on the use of radioisotopes in soil and plant investigations in Manila, Philippines. Held from 3 October to 25 November 1966, the course was organised by the International Atomic Energy Agency (IAEA) and the Food and Agricultural Organization (FAO) under the UN Expanded Programme of Technical Assistance. During the first three weeks, the students, most of whom had graduate training or experience in agricultural research, were taught the basic characteristics of isotopes and the techniques of measuring radiation. Lectures and practical laboratory exercises in the more specialized studies of soil-plant relations took up the rest of the time. Some of the topics covered were: field and water culture experiments, measurement of nutrient in the soil, autoradiography of plant materials, plant mutation and breeding, use of radioisotopes in the study of photosynthesis and plant growth, nuclear techniques for determining soil moisture and density, the use of labelled fertilizer in studying the efficient utilization of fertilizer, etc. Dr. Getulio B. Viado, Head of the Training Institute, Philippine Atomic Energy Commission, was Director of the course, while Dr. Shaukat Ahmed, Director of the Atomic Research Centre, West Pakistan, served as Technical Adviser and as a principal lecturer. The teaching staff consisted of Philippine scientists and three visiting professors: Dr. Victor Middelboe of the IAEA Seibersdorf Laboratory, Dr. M.S. Chandraratna of Ceylon and Dr. S.C. Chang of the Republic of China. (author)

  3. Guidebook on radioisotope tracers in industry

    International Nuclear Information System (INIS)

    1990-01-01

    The idea of using tracers (chemical, dyes, etc.) in the investigation of complex physical phenomena has always attracted the attention of scientists and engineers. When radioactive isotopes became available it was immediately recognized that they offered an almost ideal solution to tracer selection. This book is devoted to reviewing the present status of the tracer method as such and to its applications to those branches of industry which have derived large benefits from the use of this modern technology. The main objectives of the IAEA's Industrial Applications and Chemistry Section is to help Member States in introducing to their own industries the different isotope and radiation techniques which have become available as a result of developments in the nuclear sciences. This section proposed the preparation of this guidebook, putting together various radiotracer methods and the experience obtained so far in their industrial use. Chapters 2 to 4 cover the general concept of tracers, technology and safety aspects, as well as data evaluation and interpretation. In chapter 5, therefore, general applications are discussed. In chapter 6, specialists in selected fields discuss their experience in radiotracer applications in various types of industrial activity. Most case studies are illustrated by at least one detailed example of an experiment carried out at an industrial installation. Current trends in the development of radiotracer methods are discussed in chapter 7, from both a theoretical and a practical viewpoint. Some possible new RTT applications in the future are also discussed here. Sealed radioactive sources are used almost as often as radioisotope tracers in industrial measurements. Annex I gives a short review of these techniques. Readers who are interested in the basic principles of radioisotope production will find the necessary information in Annex II. Annexes III, V and VI provide a demonstration of fundamental relations and properties; useful

  4. Recent developments in radiation equipment and radioisotopes

    International Nuclear Information System (INIS)

    Beddoes, J.M.

    1978-09-01

    A review is given of the technology of the uses of radiation equipment and radioisotopes, in which field Canada has long been a world leader. AECL Commercial Products has pioneered many of the most important applications. The development and sale of Co-60 radiation teletherapy units for cancer treatment is a familiar example of such an application and Commercial Products dominates the world market. Another such example is the marketing of Mo-99, which is produced in the NRX and NRU reactors at Chalk River, and from which the short-lived daughter Tc-99 is eluted as required for use in in-vivo diagnosis. New products coming into use for this purpose include Tl-201, I-123, Ga-67 and In-111, all produced in the TRIUMF cyclotron in Vancouver, while I-125 continues to be in demand for in-vitro radioimmunoassays. Radioisotopes continue to play an important part in manufacturing, where their well-known uses include controlling thickness, contents, etc., in production, and industrial radiography. The application of large industrial irradiators for the sterilization of medical products is now a major world industry for which Commercial Products is the main manufacturer. Isotopes are also used in products such as smoke detectors. Isotopes continue to find extensive use as tracers, both in industrial applications and in animal and plant biology studies. Some more recent uses include pest control by the Σsterile maleΣ technique and neutron activation and delayed neutron counting in uranium assay. The review concludes with an account of the development and prospects of AECL Commercial Products. (author)

  5. Training in radioisotope uses for agricultural investigations

    International Nuclear Information System (INIS)

    1966-01-01

    Full text: Seventeen students from Cambodia, the Republic of China, India, Israel, Pakistan, the Philippines, Syria, Thailand and the United Arab Republic attended an inter-regional training course on the use of radioisotopes in soil and plant investigations in Manila, Philippines. Held from 3 October to 25 November 1966, the course was organised by the International Atomic Energy Agency (IAEA) and the Food and Agricultural Organization (FAO) under the UN Expanded Programme of Technical Assistance. During the first three weeks, the students, most of whom had graduate training or experience in agricultural research, were taught the basic characteristics of isotopes and the techniques of measuring radiation. Lectures and practical laboratory exercises in the more specialized studies of soil-plant relations took up the rest of the time. Some of the topics covered were: field and water culture experiments, measurement of nutrient in the soil, autoradiography of plant materials, plant mutation and breeding, use of radioisotopes in the study of photosynthesis and plant growth, nuclear techniques for determining soil moisture and density, the use of labelled fertilizer in studying the efficient utilization of fertilizer, etc. Dr. Getulio B. Viado, Head of the Training Institute, Philippine Atomic Energy Commission, was Director of the course, while Dr. Shaukat Ahmed, Director of the Atomic Research Centre, West Pakistan, served as Technical Adviser and as a principal lecturer. The teaching staff consisted of Philippine scientists and three visiting professors: Dr. Victor Middelboe of the IAEA Seibersdorf Laboratory, Dr. M.S. Chandraratna of Ceylon and Dr. S.C. Chang of the Republic of China. (author)

  6. Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease.

    Science.gov (United States)

    Catalano, Onofrio Antonio; Wu, Vincent; Mahmood, Umar; Signore, Alberto; Vangel, Mark; Soricelli, Andrea; Salvatore, Marco; Gervais, Debra; Rosen, Bruce R

    2018-01-01

    This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease.

  7. Comparison of PET/CT and PET/MRI hybrid systems using a 68Ga-labelled PSMA ligand for the diagnosis of recurrent prostate cancer: initial experience

    International Nuclear Information System (INIS)

    Afshar-Oromieh, A.; Haberkorn, U.; Schlemmer, H.P.; Fenchel, M.; Roethke, M.; Eder, M.; Eisenhut, M.; Hadaschik, B.A.; Kopp-Schneider, A.

    2014-01-01

    68 Ga-labelled HBED-CC-PSMA is a highly promising tracer for imaging recurrent prostate cancer (PCa). The intention of this study was to evaluate the feasibility of PET/MRI with this tracer. Twenty patients underwent PET/CT 1 h after injection of the 68 Ga-PSMA ligand followed by PET/MRI 3 h after injection. Data from the two investigations were first analysed separately and then compared with respect to tumour detection rate and radiotracer uptake in various tissues. To evaluate the quantification accuracy of the PET/MRI system, differences in SUVs between PET/CT and corresponding PET/MRI were compared with differences in SUVs between PET/CT 1 h and 3 h after injection in another patient cohort. This cohort was investigated using the same PET/CT system. With PET/MRI, different diagnostic sequences, higher contrast of lesions and higher resolution of MRI enabled a subjectively easier evaluation of the images. In addition, four unclear findings on PET/CT could be clarified as characteristic of PCa metastases by PET/MRI. However, in PET images of the PET/MRI, a reduced signal was observed at the level of the kidneys (in 11 patients) and around the urinary bladder (in 15 patients). This led to reduced SUVs in six lesions. SUV mean values provided by the PET/MRI system were different in muscles, blood pool, liver and spleen. PCa was detected more easily and more accurately with Ga-PSMA PET/MRI than with PET/CT and with lower radiation exposure. Consequently, this new technique could clarify unclear findings on PET/CT. However, scatter correction was challenging when the specific 68 Ga-PSMA ligand was used. Moreover, direct comparison of SUVs from PET/CT and PET/MR needs to be conducted carefully. (orig.)

  8. Development and application of industrial radioisotope instruments in China

    International Nuclear Information System (INIS)

    Lu Yanxiao

    1994-09-01

    Industrial radioisotope instruments are emerging as advanced monitoring, controlling and automation tools for industries in China. Especially the on-line analysis systems based on radioisotope instruments, referred to as nucleonic control systems (NCS), have more and more important role in the modernization and optimization of industrial processes. Over nearly four decades significant progress has been made in the development and application of radioisotope instruments in China. After a brief review of the history of radioisotope instruments, the state of the art of this kind of instruments and recent examples of their applications are given. Technical and economic benefits have resulted from the industrial applications of radioisotope instruments and the sales of products of their own in marketing. It is expected that along with the high speed growth of national economy, there will be greater demand for radioisotope instruments and nucleonic control systems in Chinese industry to promote the technological transformation and progress of traditional industries and to establish high-tech industries with technology-intensive products. Sustained efforts for the research and development of radioisotope instrument should be made to up-grade domestic instruments and to satisfy the needs of the smaller scale industries more common in China for low cost systems. (1 fig., 2 tabs.)

  9. Computerized control system for administration of the radioisotope use

    International Nuclear Information System (INIS)

    Sago, Tsutomu; Ito, Shin; Isozumi, Yasuhito; Kurihara, Norio

    1986-01-01

    An on-line computer system for administration of the radioisotope use has been developed. This system consists of a multi-job type host computer and two sets of personal computers with identification card-readers. The personal computers are employed as terminal devices for radioisotope users. By the use of an identification card, entrance and leaving times are recorded automatically. Furthermore, an easy operation of the personal computer permits users to access to the information of their resistered radioisotopes, such as nuclides, chemical forms, updated activities, storage locations, and history of usage. A recording sheet on which those data are printed is provided from the personal computer. After the use of radioisotopes, users can record their data on the recording sheets. These records are used as the input data to this system to update the data of the used radioisotopes. Owing to the concise format of the recording sheet and various sorting programs developed in present work, this system enables us to grasp the exact flow of the radioisotopes from purchase to disposal. Out-put data from high-speed kanji printer can provide many important books which are legally requested to be kept for administration of the radioisotope use. (author)

  10. Future radioisotope power needs for missions to the solar system

    International Nuclear Information System (INIS)

    Mondt, J.F.; Underwood, M.L.; Nesmith, B.J.

    1997-01-01

    NASA and DOE plan a cooperative team effort with industry, government laboratories and universities to develop a near term, low cost, low power (100 watt electric class), low mass (<10 kg), advanced radioisotope space power source (ARPS) and in the process reduce the plutonium-related costs as well. The near term is focused on developing an advanced energy converter to use with the General Purpose Heat Source (GPHS). The GPHS was developed and used for the current radioisotope thermoelectric generators (RTGs). Advanced energy converter technologies are needed as a more efficient replacement for the existing thermoelectric converters so that the space radioisotope power source mass and cost can be reduced. a more advanced technology space radioisotope power system program is also planned that addresses a longer-term need. Twenty first century robotic scientific information missions to the outer planets and beyond are planned to be accomplished with microspacecraft which may demand safe, even more compact, lower-power, lower-mass radioisotope power sources than those which can be achieved as a result of the near term efforts. The longer-term program focuses not only on converter technology but also on lower power, more compact radioisotope heat source technology and smaller, lower mass radioisotope heater units for second generation microspacecraft. This more ambitious, longer time-horizon focus necessarily occurs at this time on the technology R and D level rather than at the system technology level

  11. Radio-Isotopes Section, radiation Safety Division, Ministry Of The Environment, Israel: A General Review, And Future Developments

    International Nuclear Information System (INIS)

    Ben-Zion, S.

    1999-01-01

    The section of radio-isotopes in the Ministry Of Environment, is responsible for preventing environmental hazards fi.om radio-isotopes ''from cradle to grave's'. The management and the supervision of radioactive materials, includes about 350 institutes in Israel. We are dealing with the implementation and the enforcement of the environmental regulations and safety standards, and licensing for each institution and installation. Among our tasks are the following: Follow-up of the import, transportation and distribution, usage and storage and disposal of radio-isotopes, as well as legislation, risk-assessments, inspection, , and ''education'. We are also participating in committees / working groups discussing specific topics: Radioactive stores, Low RW disposal, Y2K, GIS, penalties charging, transportation and more

  12. Experimental validation of gallium production and isotope-dependent positron range correction in PET

    Energy Technology Data Exchange (ETDEWEB)

    Fraile, L.M., E-mail: lmfraile@ucm.es [Grupo de Física Nuclear, Dpto. Física Atómica, Molecular y Nuclear, Universidad Complutense de Madrid (Spain); Herraiz, J.L.; Udías, J.M.; Cal-González, J.; Corzo, P.M.G.; España, S.; Herranz, E.; Pérez-Liva, M.; Picado, E.; Vicente, E. [Grupo de Física Nuclear, Dpto. Física Atómica, Molecular y Nuclear, Universidad Complutense de Madrid (Spain); Muñoz-Martín, A. [Centro de Microanálisis de Materiales, Universidad Autónoma de Madrid, E-28049 Madrid (Spain); Vaquero, J.J. [Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid (Spain)

    2016-04-01

    Positron range (PR) is one of the important factors that limit the spatial resolution of positron emission tomography (PET) preclinical images. Its blurring effect can be corrected to a large extent if the appropriate method is used during the image reconstruction. Nevertheless, this correction requires an accurate modelling of the PR for the particular radionuclide and materials in the sample under study. In this work we investigate PET imaging with {sup 68}Ga and {sup 66}Ga radioisotopes, which have a large PR and are being used in many preclinical and clinical PET studies. We produced a {sup 68}Ga and {sup 66}Ga phantom on a natural zinc target through (p,n) reactions using the 9-MeV proton beam delivered by the 5-MV CMAM tandetron accelerator. The phantom was imaged in an ARGUS small animal PET/CT scanner and reconstructed with a fully 3D iterative algorithm, with and without PR corrections. The reconstructed images at different time frames show significant improvement in spatial resolution when the appropriate PR is applied for each frame, by taking into account the relative amount of each isotope in the sample. With these results we validate our previously proposed PR correction method for isotopes with large PR. Additionally, we explore the feasibility of PET imaging with {sup 68}Ga and {sup 66}Ga radioisotopes in proton therapy.

  13. From 1962 the teaching of Methodology of Radioisotopes is continuous in the University of Buenos Aires of the Argentine Republic

    International Nuclear Information System (INIS)

    Rivera, E.; Cremaschi, G.; Martin, G.; Zubillaga, M.; Cricco, G.; Davio, C.; Genaro, A.; Bianchin, A.; Mohamad, N.; Klecha, A.; Calmanovici, G.; Goldman, G.; Salgueiro, J.; Nunez, M.; Medina, V.; Gutierrez, A.; Leonardi, N.; Bergoc, R.

    2006-01-01

    . Formation of university extension: f) Methodology of Radioisotopes like Technicature. From 1962, the training of technicians was made parallel to that of professionals. From 1997 a Specific Course of Technicians in Nuclear Medicine is dictated, with an own curricular organization and chord to the basic formation of the assistants and its particular professional expectation. All the courses are credited by the Argentine Nuclear Regulatory Authority (ARN). The approval requires of a written exam and a colloquy in which the assistants demonstrate to be able to implement the measures of radiological protection in their labor environments. In their dictation participate professionals of the more high academic level (Ph.D.) and noted member specialists of the ARN. (Author)

  14. SU-E-I-86: Ultra-Low Dose Computed Tomography Attenuation Correction for Pediatric PET CT Using Adaptive Statistical Iterative Reconstruction (ASiR™)

    Energy Technology Data Exchange (ETDEWEB)

    Brady, S; Shulkin, B [St. Jude Children’s Research Hospital, Memphis, TN (United States)

    2015-06-15

    Purpose: To develop ultra-low dose computed tomography (CT) attenuation correction (CTAC) acquisition protocols for pediatric positron emission tomography CT (PET CT). Methods: A GE Discovery 690 PET CT hybrid scanner was used to investigate the change to quantitative PET and CT measurements when operated at ultra-low doses (10–35 mAs). CT quantitation: noise, low-contrast resolution, and CT numbers for eleven tissue substitutes were analyzed in-phantom. CT quantitation was analyzed to a reduction of 90% CTDIvol (0.39/3.64; mGy) radiation dose from baseline. To minimize noise infiltration, 100% adaptive statistical iterative reconstruction (ASiR) was used for CT reconstruction. PET images were reconstructed with the lower-dose CTAC iterations and analyzed for: maximum body weight standardized uptake value (SUVbw) of various diameter targets (range 8–37 mm), background uniformity, and spatial resolution. Radiation organ dose, as derived from patient exam size specific dose estimate (SSDE), was converted to effective dose using the standard ICRP report 103 method. Effective dose and CTAC noise magnitude were compared for 140 patient examinations (76 post-ASiR implementation) to determine relative patient population dose reduction and noise control. Results: CT numbers were constant to within 10% from the non-dose reduced CTAC image down to 90% dose reduction. No change in SUVbw, background percent uniformity, or spatial resolution for PET images reconstructed with CTAC protocols reconstructed with ASiR and down to 90% dose reduction. Patient population effective dose analysis demonstrated relative CTAC dose reductions between 62%–86% (3.2/8.3−0.9/6.2; mSv). Noise magnitude in dose-reduced patient images increased but was not statistically different from pre dose-reduced patient images. Conclusion: Using ASiR allowed for aggressive reduction in CTAC dose with no change in PET reconstructed images while maintaining sufficient image quality for co

  15. Selecting Safe Pets (For Parents)

    Science.gov (United States)

    ... supplies (pet bowls, pet bed, leash, etc.) as gifts, then selecting the pet as a family. That way, everyone has time to really think about whether your family is ready for a pet. Key Questions Before adopting or purchasing any pet, talk to all family members, discuss ...

  16. Production and application of radioisotopes - a Canadian perspective

    International Nuclear Information System (INIS)

    O'Neill, W.P.; Evans, D.J.R.

    1988-01-01

    This paper outlines the historical evolutions of radioisotopes from first concepts and discoveries to significant milestones in their production and the development of applications throughout the world. Regarding production, it addresses the methods that have been used at various stages during this evolution outlining the important findings that have led to further developments. With respect to radioisotope applications, the paper addresses the development of markets in industry, medicine, and agriculture and comments on the size of these markets and their rate of growth. Throughout, the paper highlights the Canadian experience and it also presents a Canadian view of emerging prospects and a forecast of how the future for radioisotopes might develop

  17. Utilization of radioisotopes and irradiation in crop protection research

    International Nuclear Information System (INIS)

    Ong, S.H.

    1981-01-01

    There is a growing realization of the benefits which may be derived from the application of radioisotopes and radiation sources in the different disciplines of crop protection research. Many investigations which might only be carried out with extreme difficulty or not all by conventional methods, could be pursued with relative ease. Radioisotopes and irradiation have been utilized in understanding the physiology and behaviour of pests and their biochemical processes and in consequence, have contributed beneficially to the development of better control techniques and more effective pesticides. On the environmental aspects, radioisotopic techniques have provided a useful tool in understanding the behaviour, metabolism and residues of pesticides in the environment. (author)

  18. Imaging corn plants with PhytoPET, a modular PET system for plant biology

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.; Kross, B.; McKisson, J.; McKisson, J. E.; Weisenberger, A. G.; Xi, W.; Zorn, C.; Bonito, G.; Howell, C. R.; Reid, C. D.; Crowell, A.; Cumberbatch, L. C.; Topp, C.; Smith, M. F.

    2013-11-01

    PhytoPET is a modular positron emission tomography (PET) system designed specifically for plant imaging. The PhytoPET design allows flexible arrangements of PET detectors based on individual standalone detector modules built from single Hamamatsu H8500 position sensitive photomultiplier tubes and pixelated LYSO arrays. We have used the PhytoPET system to perform preliminary corn plant imaging studies at the Duke University Biology Department Phytotron. Initial evaluation of the PhytoPET system to image the biodistribution of the positron emitting tracer {sup 11}C in corn plants is presented. {sup 11}CO{sub 2} is loaded into corn seedlings by a leaf-labeling cuvette and translocation of {sup 11}C-sugars is imaged by a flexible arrangement of PhytoPET modules on each side. The PhytoPET system successfully images {sup 11}C within corn plants and allows for the dynamic measurement of {sup 11}C-sugar translocation from the leaf to the roots.

  19. Pet-Related Infections.

    Science.gov (United States)

    Day, Michael J

    2016-11-15

    Physicians and veterinarians have many opportunities to partner in promoting the well-being of people and their pets, especially by addressing zoonotic diseases that may be transmitted between a pet and a human family member. Common cutaneous pet-acquired zoonoses are dermatophytosis (ringworm) and sarcoptic mange (scabies), which are both readily treated. Toxoplasmosis can be acquired from exposure to cat feces, but appropriate hygienic measures can minimize the risk to pregnant women. Persons who work with animals are at increased risk of acquiring bartonellosis (e.g., cat-scratch disease); control of cat fleas is essential to minimize the risk of these infections. People and their pets share a range of tick-borne diseases, and exposure risk can be minimized with use of tick repellent, prompt tick removal, and appropriate tick control measures for pets. Pets such as reptiles, amphibians, and backyard poultry pose a risk of transmitting Salmonella species and are becoming more popular. Personal hygiene after interacting with these pets is crucial to prevent Salmonella infections. Leptospirosis is more often acquired from wildlife than infected dogs, but at-risk dogs can be protected with vaccination. The clinical history in the primary care office should routinely include questions about pets and occupational or other exposure to pet animals. Control and prevention of zoonoses are best achieved by enhancing communication between physicians and veterinarians to ensure patients know the risks of and how to prevent zoonoses in themselves, their pets, and other people.

  20. Present and future of PET and PET/CT in gynaecologic malignancies

    International Nuclear Information System (INIS)

    Musto, Alessandra; Rampin, Lucia; Nanni, Cristina; Marzola, Maria Cristina; Fanti, Stefano; Rubello, Domenico

    2011-01-01

    Objectives: To review the published data in literature on patients affected by gynaecological malignancies to establish the role of 18 F-FDG positron emission tomography (PET) and PET/CT in comparison to conventional imaging (CI). Materials and methods: All papers specifically addressed to the role of 18 F-FDG PET and PET/CT in gynaecological malignancies published on PubMed/Medline, in abstracts from the principal international congresses, in the guidelines from national Societies that had appeared in literature until November 2009 were considered for the purpose of the present study. Results and conclusions: The use of 18 F-FDG PET, and even more of 18 F-FDG PET/CT, is increasing in the follow up of patients with gynaecologic malignancies and suspected recurrent disease: there is evidence in the literature that 18 F-FDG PET/CT has a higher sensitivity than CI in depicting occult metastatic spread. An interesting issue is represented by patients with ovarian cancer with an increase of the specific biomarker, CA-125, and negative/inconclusive findings at CI. The use of 18 F-FDG PET in differential diagnosis and staging is more controversial, but there is some evidence that a baseline PET examination performed before commencing therapy, for staging purpose, is also useful to evaluate the response to chemoradiation treatment. In several papers it has been suggested a relevant role of 18 F-FDG PET/CT in evaluating the entity of response to treatment and therefore to plan the subsequent therapeutic strategy.