WorldWideScience

Sample records for specific aim 3a

  1. Locally specific measures for employment aimed at regional development

    Directory of Open Access Journals (Sweden)

    Vladimir Cini

    2013-12-01

    Full Text Available The oldest and largest sub-region in the world functioning on the principle of economic union is the European Union. The creation of a single market has initiated the process of conditional adjustment of markets in the EU member states, which has a significant impact on the social welfare of its citizens. It is necessary to tackle this issue by joint efforts within the European Union. As globalization processes push for economic integration and development of competitive advantage, the regions will have to make some challenging adjustments. The development tends to concentrate in highly competitive regions, while regions in the periphery lag behind. However, this pertains not only to the economic lag, but also to a potential negative political situation. Locally specific active employment policy measures are a continuation of the effort to make these measures more flexible. They refer to the Joint Assessment of Employment Policy Priorities and the IPA Human Resources Development Operational Programme - a regional policy instrument of the European Union. Both documents highlight the issue of disproportional development of regions, which requires special local measures and active labour market policy programmes. To reduce regional differences in development, it is necessary to invest more resources in the regions that lag behind. In this particular case, this means the counties in Croatia with high unemployment rates, a large number of registered unemployed persons and low employment rate. Consequently, this paper explains the importance of the adoption of locally specific measures for employment, which unfortunately did not take hold in the Republic of Croatia, and highlights the need for further decentralization of public services, with the aim of balancing regional development

  2. The action-specific effect of execution on imagination of reciprocal aiming movements.

    Science.gov (United States)

    Yoxon, Emma; Pacione, Sandra M; Song, Joo-Hyun; Welsh, Timothy N

    2017-08-01

    Past research has shown that the movement times of imagined aiming movements were more similar to actual movement times after the individual has experienced executing the movements. The purpose of the present study was to determine if experience with a set of movements altered the imagination of movements that were not experienced. Participants imagined a series of reciprocal aiming movements in different movement difficulty contexts (created by altering target width and movement amplitude) before and after actually executing a series of aiming movements. The range of difficulties of the imagined movements included difficulty contexts that were within (Experiment 1) or outside (Experiment 2) the range of difficulty experienced during execution. It was found that imagined movement times of movements within the range of movement difficulties experienced were more consistent with Fitts' Law after movement experience, whereas imagination of more difficult movements was not altered by experience. It is suggested that execution did not enhance imagination of more difficult movements because the relative contributions of motor planning and control to the more difficult movements were different from those in the experienced movements. Thus, the enhancement of imagination through experience might only occur when mechanisms underlying the executed and imagined movements are similar. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. The Collaborative Lithium Trials (CoLT: specific aims, methods, and implementation

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    Hooper Stephen R

    2008-08-01

    Full Text Available Abstract Background Lithium is a benchmark treatment for bipolar illness in adults. However, there has been relatively little methodologically stringent research regarding the use of lithium in youth suffering from bipolarity. Methods Under the auspices of the Best Pharmaceuticals for Children Act (BPCA, a Written Request (WR pertaining to the study of lithium in pediatric mania was issued by the United States Food and Drug Administration (FDA to the National Institute of Child Health and Human Development (NICHD in 2004. Accordingly, the NICHD issued a Request for Proposals (RFP soliciting submissions to pursue this research. Subsequently, the NICHD awarded a contract to a group of investigators in order to conduct these studies. Results The Collaborative Lithium Trials (CoLT investigators, the BPCA-Coordinating Center, and the NICHD developed protocols to provide data that will: (1 establish evidence-based dosing strategies for lithium; (2 characterize the pharmacokinetics and biodisposition of lithium; (3 examine the acute efficacy of lithium in pediatric bipolarity; (4 investigate the long-term effectiveness of lithium treatment; and (5 characterize the short- and long-term safety of lithium. By undertaking two multi-phase trials rather than multiple single-phase studies (as was described in the WR, the feasibility of the research to be undertaken was enhanced while ensuring all the data outlined in the WR would be obtained. The first study consists of: (1 an 8-week open-label, randomized, escalating dose Pharmacokinetic Phase; (2 a 16-week Long-Term Effectiveness Phase; (3 a 28-week double-blind Discontinuation Phase; and (4 an 8-week open-label Restabilization Phase. The second study consists of: (1 an 8-week, double-blind, parallel-group, placebo-controlled Efficacy Phase; (2 an open-label Long-Term Effectiveness lasting either 16 or 24 weeks (depending upon blinded treatment assignment during the Efficacy Phase; (3 a 28-week double

  4. NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

    Science.gov (United States)

    Drennan, Michael B; Govindarajan, Srinath; Verheugen, Eveline; Coquet, Jonathan M; Staal, Jens; McGuire, Conor; Taghon, Tom; Leclercq, Georges; Beyaert, Rudi; van Loo, Geert; Lambrecht, Bart N; Elewaut, Dirk

    2016-09-19

    Natural killer T (NKT) cells are innate lymphocytes that differentiate into NKT1, NKT2, and NKT17 sublineages during development. However, the signaling events that control NKT sublineage specification and differentiation remain poorly understood. Here, we demonstrate that the ubiquitin-modifying enzyme TNFAIP3/A20, an upstream regulator of T cell receptor (TCR) signaling in T cells, is an essential cell-intrinsic regulator of NKT differentiation. A20 is differentially expressed during NKT cell development, regulates NKT cell maturation, and specifically controls the differentiation and survival of NKT1 and NKT2, but not NKT17, sublineages. Remaining A20-deficient NKT1 and NKT2 thymocytes are hyperactivated in vivo and secrete elevated levels of Th1 and Th2 cytokines after TCR ligation in vitro. Defective NKT development was restored by compound deficiency of MALT1, a key downstream component of TCR signaling in T cells. These findings therefore show that negative regulation of TCR signaling during NKT development controls the differentiation and survival of NKT1 and NKT2 cells. © 2016 Drennan et al.

  5. Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock.

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    Mo-bin Cheng

    2014-12-01

    Full Text Available Histone lysine (K residues, which are modified by methyl- and acetyl-transferases, diversely regulate RNA synthesis. Unlike the ubiquitously activating effect of histone K acetylation, the effects of histone K methylation vary with the number of methyl groups added and with the position of these groups in the histone tails. Histone K demethylases (KDMs counteract the activity of methyl-transferases and remove methyl group(s from specific K residues in histones. KDM3A (also known as JHDM2A or JMJD1A is an H3K9me2/1 demethylase. KDM3A performs diverse functions via the regulation of its associated genes, which are involved in spermatogenesis, metabolism, and cell differentiation. However, the mechanism by which the activity of KDM3A is regulated is largely unknown. Here, we demonstrated that mitogen- and stress-activated protein kinase 1 (MSK1 specifically phosphorylates KDM3A at Ser264 (p-KDM3A, which is enriched in the regulatory regions of gene loci in the human genome. p-KDM3A directly interacts with and is recruited by the transcription factor Stat1 to activate p-KDM3A target genes under heat shock conditions. The demethylation of H3K9me2 at the Stat1 binding site specifically depends on the co-expression of p-KDM3A in the heat-shocked cells. In contrast to heat shock, IFN-γ treatment does not phosphorylate KDM3A via MSK1, thereby abrogating its downstream effects. To our knowledge, this is the first evidence that a KDM can be modified via phosphorylation to determine its specific binding to target genes in response to thermal stress.

  6. NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

    NARCIS (Netherlands)

    Drennan, M.B. (Michael B.); Govindarajan, S. (Srinath); Verheugen, E. (Eveline); Coquet, J.M. (Jonathan M.); Staal, J. (Jens); McGuire, C. (Conor); T. Taghon (Tom); G. Leclercq (Georges); R. Beyaert (Rudi); G. van Loo (Geert); B.N.M. Lambrecht (Bart); Elewaut, D. (Dirk)

    2016-01-01

    textabstractNatural killer T (NKT) cells are innate lymphocytes that differentiate into NKT1, NKT2, and NKT17 sublineages during development. However, the signaling events that control NKT sublineage specification and differentiation remain poorly understood. Here, we demonstrate that the

  7. Radiation hybrids from human chromosome 3: A basis for the construction of region and specific sublibraries

    International Nuclear Information System (INIS)

    Atchison, L.; Cosmis, R.L.; Atchison, M.L.

    1990-01-01

    The authors are interested in identifying genes on human chromosome involved in disease processes. To date at least 20 different loci on this chromosome are implicated with various disease states. DNA libraries containing clones derived from a small chromosomal subregion implicated in a particular disease would greatly assist these studies. They have utilized the radiation hybrid (RH) technique to generate a series of somatic cell hybrids that contain small segments of human chromosome 3 as the only human genetic material. A Chinese hamster-human cell hybrid (Q314-2) containing only human chromosome 3 was used to prepare radiation hybrids. Cells were lethally X-irradiated with 6,000 rads and fused to Urd(??) Chinese hamster cells by PEG 1000 treatment. The majority of hybrids (>72%) analyzed retained portions of chromosome 3. The amount of chromosome 3 in each hybrid ranged from nearly all of the chromosome to very little. Currently these hybrids are being further characterized with single copy probes of known map location in order to isolate regions of chromosome 3 that contain specific disease locus. These reduced hybrids can then be used for the construction of region specific libraries and for the generation of new DNA probes from the specific region of interest

  8. Expression Analysis of ARMC3, a Testis-Specific Gene, in Breast Cancer Patients

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    Zare

    2016-02-01

    Full Text Available Background Breast cancer is the most prevalent cancer among women. Biomarkers that are expressed in tumors play a pivotal role in diagnosis and treatment. Cancer-testis (CT antigens are predominantly expressed in the testis and also have inappropriate expression in various tumor types. In the case of expression in tumors, they will be used as immunotherapy targets. Objectives Expression of ARMC3, a CT antigen, was analyzed to determine its potential as a tumor marker for breast cancer. Materials and Methods Eighty samples including 40 tumor samples and 40 normal adjacent tissue samples, were gathered from the ICBC biobank. RNA extraction was carried out on all samples. The extracted RNA was treated by DNaseI, after which cDNA was synthesized. Expression of ARMC3 with ACTB (internal control was studied using Real-Time PCR (polymerase chain reaction. Results Overall, 43.6% of tumors and 25.6% of normal adjacent tissues expressed ARMC3. ARMC3 was overexpressed in 41% of tumor samples (P = 0.00 and showed decreased expression in 46.2% (P = 0.00. Also, the expression of this gene in 12.8% of tumors was unchanged, which was statistically significant. It should be noted that all samples expressed ACTB gene. Conclusions Expression of ARMC3 in tumor samples and normal adjacent tissue is very important. The expression of this gene in tumor-adjacent tissue may be associated with the stage of cancer; it may be that these tissues are affected by epigenetic and oncogenic changes of breast cancer. Accordingly, aberrant expression of ARMC3 in tumor samples may be an attractive candidate for use as a tumor marker.

  9. Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

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    Raisa Eng S

    2010-01-01

    Full Text Available Abstract The transcription factor Brn3a, product of the pou4f1 gene, is expressed in most sensory neurons throughout embryogenesis. Prior work has demonstrated a role for Brn3a in the repression of early neurogenic genes; here we describe a second major role for Brn3a in the specification of sensory subtypes in the trigeminal ganglion (TG. Sensory neurons initially co-express multiple Trk-family neurotrophin receptors, but are later marked by the unique expression of TrkA, TrkB or TrkC. Maturation of these sensory subtypes is known to depend on the expression of Runx transcription factors. Newborn Brn3a knockout mice fail to express TrkC, which is associated in the TG with mechanoreceptors, plus a set of functional genes associated with nociceptor subtypes. In embryonic Brn3a-/- ganglia, the normal expression of Runx3 is never initiated in TrkC+ neurons, and Runx1 expression is greatly attenuated in TrkA+ nociceptors. These changes are accompanied by expanded expression of TrkB in neurons that abnormally express multiple Trks, followed by the loss of TrkC and TrkA expression. In transgenic embryos expressing a Brn3a-VP16 dominant transactivator, Runx3 mRNA expression is increased, suggesting that it is a direct regulatory target of Brn3a. Chromatin immunoprecipitation confirms that Brn3a binds in vivo to a conserved upstream enhancer element within histone H3-acetylated chromatin in the Runx3 locus. Together these data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes.

  10. Mutations in TET2 and DNMT3A genes are associated with changes in global and gene-specific methylation in acute myeloid leukemia.

    Science.gov (United States)

    Ponciano-Gómez, Alberto; Martínez-Tovar, Adolfo; Vela-Ojeda, Jorge; Olarte-Carrillo, Irma; Centeno-Cruz, Federico; Garrido, Efraín

    2017-10-01

    Acute myeloid leukemia is characterized by its high biological and clinical heterogeneity, which represents an important barrier for a precise disease classification and accurate therapy. While epigenetic aberrations play a pivotal role in acute myeloid leukemia pathophysiology, molecular signatures such as change in the DNA methylation patterns and genetic mutations in enzymes needed to the methylation process can also be helpful for classifying acute myeloid leukemia. Our study aims to unveil the relevance of DNMT3A and TET2 genes in global and specific methylation patterns in acute myeloid leukemia. Peripheral blood samples from 110 untreated patients with acute myeloid leukemia and 15 healthy control individuals were collected. Global 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA from peripheral blood leukocytes were measured by using the MethylFlashTM Quantification kits. DNMT3A and TET2 expression levels were evaluated by real-time quantitative polymerase chain reaction. The R882A hotspot of DNMT3A and exons 6-10 of TET2 were amplified by polymerase chain reaction and sequenced using the Sanger method. Methylation patterns of 16 gene promoters were evaluated by pyrosequencing after treating DNA with sodium bisulfite, and their transcriptional products were measured by real-time quantitative polymerase chain reaction.Here, we demonstrate altered levels of 5-methylcytosine and 5-hydroxymethylcytosine and highly variable transcript levels of DNMT3A and TET2 in peripheral blood leukocytes from acute myeloid leukemia patients. We found a mutation prevalence of 2.7% for DNMT3A and 11.8% for TET2 in the Mexican population with this disease. The average overall survival of acute myeloid leukemia patients with DNMT3A mutations was only 4 months. In addition, we showed that mutations in DNMT3A and TET2 may cause irregular DNA methylation patterns and transcriptional expression levels in 16 genes known to be involved in acute myeloid leukemia pathogenesis

  11. AIMES Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Katz, Daniel S [Univ. of Illinois, Urbana-Champaign, IL (United States). National Center for Supercomputing Applications (NCSA); Jha, Shantenu [Rutgers Univ., New Brunswick, NJ (United States); Weissman, Jon [Univ. of Minnesota, Minneapolis, MN (United States); Turilli, Matteo [Rutgers Univ., New Brunswick, NJ (United States)

    2017-01-31

    This is the final technical report for the AIMES project. Many important advances in science and engineering are due to large-scale distributed computing. Notwithstanding this reliance, we are still learning how to design and deploy large-scale production Distributed Computing Infrastructures (DCI). This is evidenced by missing design principles for DCI, and an absence of generally acceptable and usable distributed computing abstractions. The AIMES project was conceived against this backdrop, following on the heels of a comprehensive survey of scientific distributed applications. AIMES laid the foundations to address the tripartite challenge of dynamic resource management, integrating information, and portable and interoperable distributed applications. Four abstractions were defined and implemented: skeleton, resource bundle, pilot, and execution strategy. The four abstractions were implemented into software modules and then aggregated into the AIMES middleware. This middleware successfully integrates information across the application layer (skeletons) and resource layer (Bundles), derives a suitable execution strategy for the given skeleton and enacts its execution by means of pilots on one or more resources, depending on the application requirements, and resource availabilities and capabilities.

  12. Cotton, Prof. Aime Auguste

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Cotton, Prof. Aime Auguste. Date of birth: 9 October 1869. Date of death: 16 April 1951. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the ...

  13. AIM Data Services

    Directory of Open Access Journals (Sweden)

    Michael Scholz

    2016-05-01

    Full Text Available AIM Data Services as a virtual facility provides virtual 3D reference tracks for simulation applications in the domain of automotive and railway systems. It offers tools for management and analysis of experiment data and a platform for survey and processing of vehicle data in the public transport domain. Collected spatial data is bundled in a database cluster and published through common web mapping interfaces.

  14. AIMES Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Jha, Shantenu [Rutgers Univ., New Brunswick, NJ (United States)

    2017-01-31

    Many important advances in science and engineering are due to large-scale distributed computing. Notwithstanding this reliance, we are still learning how to design and deploy large-scale production Distributed Computing Infrastructures (DCI). The AIMES project was conceived against this backdrop, following on the heels of a comprehensive survey of scienti c distributed applications [1]. The survey established, arguably for the rst time, the relationship between infrastructure and scienti c distributed applications. It examined well known contributors to the complexity associated with infrastructure, such as inconsistent internal and external interfaces, and demonstrated the correlation with application brittleness. It discussed how infrastructure complexity reinforces the challenges inherent in developing distributed applications.

  15. GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility.

    Science.gov (United States)

    Judson, Matthew C; Wallace, Michael L; Sidorov, Michael S; Burette, Alain C; Gu, Bin; van Woerden, Geeske M; King, Ian F; Han, Ji Eun; Zylka, Mark J; Elgersma, Ype; Weinberg, Richard J; Philpot, Benjamin D

    2016-04-06

    Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequences of selective Ube3a loss from either GABAergic or glutamatergic neurons, focusing on the development of hyperexcitability within L2/3 neocortex and in broader circuit and behavioral contexts. We find that GABAergic Ube3a loss causes AS-like increases in neocortical EEG delta power, enhances seizure susceptibility, and leads to presynaptic accumulation of clathrin-coated vesicles (CCVs)-all without decreasing GABAergic inhibition onto L2/3 pyramidal neurons. Conversely, glutamatergic Ube3a loss fails to yield EEG abnormalities, seizures, or associated CCV phenotypes, despite impairing tonic inhibition onto L2/3 pyramidal neurons. These results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in AS mice, lending insight into ictogenic mechanisms in AS. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. GABAergic neuron-specific loss of Ube3a causes Angelman syndrome-like EEG abnormalities and enhances seizure susceptibility

    Science.gov (United States)

    Judson, Matthew C.; Wallace, Michael L.; Sidorov, Michael S.; Burette, Alain C.; Gu, Bin; van Woerden, Geeske M.; King, Ian F.; Han, Ji Eun; Zylka, Mark J.; Elgersma, Ype; Weinberg, Richard J.; Philpot, Benjamin D.

    2016-01-01

    SUMMARY Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequences of selective Ube3a loss from either GABAergic or glutamatergic neurons, focusing on the development of hyperexcitability within L2/3 neocortex and in broader circuit and behavioral contexts. We find that GABAergic Ube3a loss causes AS-like increases in neocortical EEG delta power, enhances seizure susceptibility, and leads to presynaptic accumulation of clathrin-coated vesicles (CCVs) – all without decreasing GABAergic inhibition onto L2/3 pyramidal neurons. Conversely, glutamatergic Ube3a loss fails to yield EEG abnormalities, seizures, or associated CCV phenotypes, despite impairing tonic inhibition onto L2/3 pyramidal neurons. These results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in AS mice, lending insight into ictogenic mechanisms in AS. PMID:27021170

  17. [Transformation and expression of specific insecticide gene Bt cry3A in resident endogenetic bacteria isolated from Apriona germari (Hope) larvae intestines].

    Science.gov (United States)

    Zhongkang, Wang; Wei, He; Guoxiong, Peng; Yuxian, Xia; Qiang, Li; Youping, Yin

    2008-09-01

    Transforming the specific insecticidal gene Bt cry3A into the dominant resident endogenetic bacteria in intestines of Apriona germari (Hope) larvae to construct transgenic bacteria that can colonize and express the insecticidal gene Bt cry3A perfectly in intestines of Apriona germari (Hope) larvae. We isolated and identified the dominant resident endogenetic bacteria by traditional methods and molecular method based of 16S rDNA analysis. Two Escherichia coli--Bacillus thuringiensis shuttle plasmid pHT305a and pHT7911 which contained specific insecticidal gene Bt cry3A were transformed into two resident endogenetic bacteria Brevibacillus brevis Ag12 and Bacillus thuringiensis Ag13 isolated from A. germari larvae intestines respectively by electro-transformation. Eighteen species of bacteria have isolated and identified from Apriona germari larvae intestines and two of them (Brevibacillus brevis Ag12 and Bacillus thuringiensis Ag13) were selected as starting bacteria to recieve the Bt cry3A. The 4 transgenic engineering strains Ag12-7911, Ag12-305a, Ag13-7911 and Ag13-305a were obtained successfully and validated by testing the plasmid stability in recombinants, transformants vegetal properties, crystal poisonous protein observation, expressional protein SDS-PAGE. The Bt cry3A gene had been transformed into Brevibacillus brevis and Bacillus thuringiensis. Both bioassay and examination of the engineering strains in intestines after feeding them to larvae showed that all these transformant strains (Brevibacillus brevis Ag12-305a, Bacillus thurigiensis Ag13-305a, Brevibacillus brevis Ag12-7911 and Bacillus thurigiensis Ag13-7911) could colonize and express 65 kDa protoxin in intestines of A. germari larvae and had insecticidal activity. We obtained four transgenic bacteria that can colonize and express the target insecticide gene Bt cry3A in A. germari larvae. They may be developed as a new insecticide.

  18. Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b.

    Science.gov (United States)

    Ebata, Kevin T; Mesh, Kathryn; Liu, Shichong; Bilenky, Misha; Fekete, Alexander; Acker, Michael G; Hirst, Martin; Garcia, Benjamin A; Ramalho-Santos, Miguel

    2017-01-01

    Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that vitamin C enhances the activity of Tet enzymes in embryonic stem (ES) cells, leading to DNA demethylation and activation of germline genes. We report here that vitamin C induces a remarkably specific demethylation of histone H3 lysine 9 dimethylation (H3K9me2) in naïve ES cells. Vitamin C treatment reduces global levels of H3K9me2, but not other histone methylation marks analyzed, as measured by western blot, immunofluorescence and mass spectrometry. Vitamin C leads to widespread loss of H3K9me2 at large chromosomal domains as well as gene promoters and repeat elements. Vitamin C-induced loss of H3K9me2 occurs rapidly within 24 h and is reversible. Importantly, we found that the histone demethylases Kdm3a and Kdm3b are required for vitamin C-induced demethylation of H3K9me2. Moreover, we show that vitamin C-induced Kdm3a/b-mediated H3K9me2 demethylation and Tet-mediated DNA demethylation are independent processes at specific loci. Lastly, we document Kdm3a/b are partially required for the upregulation of germline genes by vitamin C. These results reveal a specific role for vitamin C in histone demethylation in ES cells and document that DNA methylation and H3K9me2 cooperate to silence germline genes in pluripotent cells.

  19. Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival

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    Lisa K. Mullany

    2015-10-01

    Full Text Available Evolutionary Action analyses of The Cancer Gene Atlas data sets show that many specific p53 missense and gain-of-function mutations are selectively overrepresented and functional in high-grade serous ovarian cancer (HGSC. As homozygous alleles, p53 mutants are differentially associated with specific loss of heterozygosity (R273; chromosome 17; copy number variation (R175H; chromosome 9; and up-stream, cancer-related regulatory pathways. The expression of immune-related cytokines was selectively related to p53 status, showing for the first time that specific p53 mutants impact, and are related to, the immune subtype of ovarian cancer. Although the majority (31% of HGSCs exhibit loss of heterozygosity, a significant number (24% maintain a wild-type (WT allele and represent another HGSC subtype that is not well defined. Using human and mouse cell lines, we show that specific p53 mutants differentially alter endogenous WT p53 activity; target gene expression; and responses to nutlin-3a, a small molecular that activates WT p53 leading to apoptosis, providing “proof of principle” that ovarian cancer cells expressing WT and mutant alleles represent a distinct ovarian cancer subtype. We also show that siRNA knock down of endogenous p53 in cells expressing homozygous mutant alleles causes apoptosis, whereas cells expressing WT p53 (or are heterozygous for WT and mutant p53 alleles are highly resistant. Therefore, despite different gene regulatory pathways associated with specific p53 mutants, silencing mutant p53 might be a suitable, powerful, global strategy for blocking ovarian cancer growth in those tumors that rely on mutant p53 functions for survival. Knowing p53 mutational status in HGSC should permit new strategies tailored to control this disease.

  20. Produtividade de madeira do eucalipto correlacionada com atributos do solo visando ao mapeamento de zonas específicas de manejo Eucalyptus wood productivity correlated with soil attributes aiming the mapping of management specifics regions

    Directory of Open Access Journals (Sweden)

    Morel de Passos e Carvalho

    2012-10-01

    Full Text Available A correta intervenção espacial na administração da lavoura, decorrente das zonas específicas de manejo do solo, aumenta a produtividade e a lucratividade agrícola. No ano de 2010, em Selvíria, Mato Grosso do Sul, Brasil (20° 20' S lat.; 51° 24' W long. foram empregadas correlações, espaciais e de Pearson, entre dados da planta de eucalipto e alguns atributos físico-químicos do solo, visando encontrar aquele que se correlacionasse bem com a produtividade de madeira. Para tanto, instalou-se uma rede geoestatística para a coleta de dados de solo e planta, com 120 pontos amostrais, num talhão de Eucalyptus camaldulensis de 2 anos. O solo foi um Latossolo Vermelho distrófico (Haplic Acrustox com declive de 0,025m m-1. O diâmetro basal da copa e a densidade do solo, por resultarem estreitas correlações com o volume de madeira, evidenciaram zonas específicas de manejo do solo intimamente associadas à produção de madeira do eucalipto.The perfect spatial intervention to manage the cultivation of the land, deriving from specific regions of the soil mapping, increases the agricultural productivity, as well as its clear gain. The relationships, spatial and Pearson, between eucalyptus data plant with some physical and chemical attributes of soil, in the growing season of 2011, in Selviria County, Mato Grosso do Sul State, Brazil (20° 20' S lat.; 51° 24' W long., were studied in order to obtain the one that could have the best relationship in order to improve the wood productivity. Thus, a geostatistical grid was installed for the soil and plant data collection, it contained 120 sample points, in plantation of Eucalyptus camaldulensis of 2 years old. The soil was a Dystrophic Red Latosol (Haplic Acrustox whit slope of 0.025m m-1. Due to their excellent relationship with wood productivity, the basis diameter of the crown and the bulk density showed management specific regions of soil whit high relation to eucalyptus wood productivity.

  1. The diverse aims of science.

    Science.gov (United States)

    Potochnik, Angela

    2015-10-01

    There is increasing attention to the centrality of idealization in science. One common view is that models and other idealized representations are important to science, but that they fall short in one or more ways. On this view, there must be an intermediary step between idealized representation and the traditional aims of science, including truth, explanation, and prediction. Here I develop an alternative interpretation of the relationship between idealized representation and the aims of science. I suggest that continuing, widespread idealization calls into question the idea that science aims for truth. If instead science aims to produce understanding, this would enable idealizations to directly contribute to science's epistemic success. I also use the fact of widespread idealization to motivate the idea that science's wide variety aims, epistemic and non-epistemic, are best served by different kinds of scientific products. Finally, I show how these diverse aims—most rather distant from truth—result in the expanded influence of social values on science. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Aims, assessments and workplace needs

    Science.gov (United States)

    Black, Paul

    1997-03-01

    This paper attempts to consider the aims that undergraduate physics degree courses actually reflect and serve in the light of the employment patterns of graduates and of the expressed needs of employers. Calling on evidence mainly from the UK, it reviews analyses of what degree examinations actually test, and goes on to quote criticisms of their courses and radical proposals to change them adopted by the senior physics professors in the UK. The discussion is then broadened by discussion of evidence, about the employment of graduates and about the priorities that some industrialists now give in the qualities that they look for when recruiting new graduates. The evidence leads to a view that radical changes are needed, both in courses and examinations, and that there is a need for university departments to work more closely with employers in re-formulating the aims and priorities in their teaching.

  3. Strategically Assessing International Business Course-Specific Learning Aims

    Science.gov (United States)

    Kashlak, Roger; Lorenzi, Peter; Cummings, Jeffrey

    2007-01-01

    During the past 30 years, there have been calls for universities and business schools to internationalize curriculum, students and faculty. As most U.S. business schools have added international components to their respective programs, the assessment of these programs was subsequently recommended from accreditation and competitive perspectives. To…

  4. Is Fitts' law continuous in discrete aiming?

    Directory of Open Access Journals (Sweden)

    Rita Sleimen-Malkoun

    Full Text Available The lawful continuous linear relation between movement time and task difficulty (i.e., index of difficulty; ID in a goal-directed rapid aiming task (Fitts' law has been recently challenged in reciprocal performance. Specifically, a discontinuity was observed at critical ID and was attributed to a transition between two distinct dynamic regimes that occurs with increasing difficulty. In the present paper, we show that such a discontinuity is also present in discrete aiming when ID is manipulated via target width (experiment 1 but not via target distance (experiment 2. Fitts' law's discontinuity appears, therefore, to be a suitable indicator of the underlying functional adaptations of the neuro-muscular-skeletal system to task properties/requirements, independently of reciprocal or discrete nature of the task. These findings open new perspectives to the study of dynamic regimes involved in discrete aiming and sensori-motor mechanisms underlying the speed-accuracy trade-off.

  5. Clustering, haplotype diversity and locations of MIC-3: a unique root-specific defense-related gene family in upland cotton (Gossypium hirsutum L.)

    Science.gov (United States)

    MIC-3-related genes of cotton (Gossypium spp.) were identified and shown to have root-specific expression, associated with pathogen defense-related function and specifically increased expression in root-knot nematode (RKN) resistant plants after nematode infection. Here we cloned and sequenced MIC-...

  6. Alginate Immobilization of Metabolic Enzymes (AIME) for High ...

    Science.gov (United States)

    Alginate Immobilization of Metabolic Enzymes (AIME) for High-Throughput Screening Assays DE DeGroot, RS Thomas, and SO SimmonsNational Center for Computational Toxicology, US EPA, Research Triangle Park, NC USAThe EPA’s ToxCast program utilizes a wide variety of high-throughput screening (HTS) assays to assess chemical perturbations of molecular and cellular endpoints. A key criticism of using HTS assays for toxicity assessment is the lack of xenobiotic metabolism (XM) which precludes both metabolic detoxification as well as bioactivation of chemicals tested in vitro thereby mischaracterizing the potential risk posed by these chemicals. To address this deficiency, we have developed an extracellular platform to retrofit existing HTS assays with XM activity. This platform utilizes the S9 fraction of liver homogenate encapsulated in an alginate gel network which reduces the cytotoxicity caused by direct addition of S9 to cells in culture. Alginate microspheres containing encapsulated human liver S9 were cross-linked to solid supports extending from a 96-well plate lid and were assayed using a pro-luciferin substrate specific for CYP3A4 (IPA). We demonstrate that S9 was successfully encapsulated and remained enzymatically active post-encapsulation with 5-10X the CYP3A4 activity as compared to 1 µg solubilized human liver S9. Ketoconazole, a known inhibitor of human CYP3A4, inhibited CYP3A4 activity in a concentration-dependent manner (IC50: 0.27 µM) and inhibiti

  7. Vape Factor Fast Find-Adult (VF3-A): a prototype survey method for recording brand-specific vaping factors in adult populations.

    Science.gov (United States)

    Ross, Craig S; Zhang, Tancy C; DeJong, William; Siegel, Michael

    2018-03-23

    In population studies, vaping is often treated as a dichotomous exposure (present/absent) without consideration of specific vaping devices and materials being used. A survey instrument is needed to record specific vaping devices and materials. We developed a database of 613 vaping device models and 3196 vaping liquid products, indexed by device brand, device type, liquid brand, liquid name and liquid flavour type. We developed a survey instrument to allow participants to report their vaping device and liquid from the indexed lists. The survey was pilot tested with a convenience sample of 208 adults (≥age 21). We validated the vaping device and liquid responses with a recontact survey. We report the proportion of respondents finding their products, characteristics of people finding their products and survey response times. Devices used most frequently in the past 30 days were electronic cigarettes (33% of respondents), vaping pens (28%) and vaping mods (16%). Fifty-seven per cent used liquids containing nicotine most frequently in the past 30 days, followed by liquids without nicotine (20%) and marijuana or hashish (10%). Most (85%) participants found their vaping device successfully (median 19.7 s) and 74% found their vaping liquid (median 19.8 s). Females and older adults were less likely to find their devices and liquids. Responses were validated for 91% and 76% of devices and e-liquids, respectively. This study demonstrated the feasibility of an internet-based survey instrument to record specific vaping factors for use in studies of vaping and health. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  8. ZmDof3, a maize endosperm-specific Dof protein gene, regulates starch accumulation and aleurone development in maize endosperm.

    Science.gov (United States)

    Qi, Xin; Li, Shixue; Zhu, Yaxi; Zhao, Qian; Zhu, Dengyun; Yu, Jingjuan

    2017-01-01

    To explore the function of Dof transcription factors during kernel development in maize, we first identified Dof genes in the maize genome. We found that ZmDof3 was exclusively expressed in the endosperm of maize kernel and had the features of a Dof transcription factor. Suppression of ZmDof3 resulted in a defective kernel phenotype with reduced starch content and a partially patchy aleurone layer. The expression levels of starch synthesis-related genes and aleurone differentiation-associated genes were down-regulated in ZmDof3 knockdown kernels, indicating that ZmDof3 plays an important role in maize endosperm development. The maize endosperm, occupying a large proportion of the kernel, plays an important role in seed development and germination. Current knowledge regarding the regulation of endosperm development is limited. Dof proteins, a family of plant-specific transcription factors, play critical roles in diverse biological processes. In this study, an endosperm-specific Dof protein gene, ZmDof3, was identified in maize through genome-wide screening. Suppression of ZmDof3 resulted in a defective kernel phenotype. The endosperm of ZmDof3 knockdown kernels was loosely packed with irregular starch granules observed by electronic microscope. Through genome-wide expression profiling, we found that down-regulated genes were enriched in GO terms related to carbohydrate metabolism. Moreover, ZmDof3 could bind to the Dof core element in the promoter of starch biosynthesis genes Du1 and Su2 in vitro and in vivo. In addition, the aleurone at local position in mature ZmDof3 knockdown kernels varied from one to three layers, which consisted of smaller and irregular cells. Further analyses showed that knockdown of ZmDof3 reduced the expression of Nkd1, which is involved in aleurone cell differentiation, and that ZmDof3 could bind to the Dof core element in the Nkd1 promoter. Our study reveals that ZmDof3 functions in maize endosperm development as a positive regulator in

  9. Recycled aggregate in road construction following the Spanish General Technical Specifications for Roads and Bridge Works (PG-3: a case study

    Directory of Open Access Journals (Sweden)

    Martín-Morales, M.

    2013-03-01

    Full Text Available This research characterizes four samples of recycled aggregate for their potential use in road construction projects in consonance with the Spanish General Technical Specifications for Roads and Bridge Works (PG-3. Although some fractions were of sufficient quality for the construction of embankments, backfills, and quarry-run fills, they were ultimately found to be unsuitable for the construction of underground drainage, granular structural layers, soil stabilization and concrete pavements. They were negatively evaluated because of their particle size distribution and sulfate content. Nevertheless, the quality of this recycled aggregate could be substantially improved by manually removing the gypsum before the crushing process at the plant or by selecting the material with greater care at the beginning of the process. Finally, we suggest that Construction and Demolition (C&D waste plant managers should modify the manufacturing process to obtain a suitable particle size distribution in accordance with PG-3 requirements and the projected use of the aggregate.

    En esta investigación se han caracterizado cuatro muestras de árido reciclado para su potencial uso en obras de carreteras en España siguiendo el Pliego de Prescripciones Técnicas Generales para Obras de Carreteras y Puentes (PG-3. Aunque algunas fracciones presentaron suficiente calidad para la construcción de terraplenes, rellenos localizados y rellenos todo en uno, resultaron inadecuadas para la construcción de drenes subterráneos, zahorras, suelos estabilizados y pavimentos de hormigón. Obtuvieron una evaluación negativa en cuanto a distribución granulométrica y contenido en sulfatos. No obstante, la calidad de este árido reciclado podría mejorar sustancialmente eliminando manualmente el yeso antes de la trituración en planta o seleccionando el material con un mayor cuidado al inicio del proceso. Finalmente, recomendamos que los empresarios de las plantas de residuos

  10. Discrimination and the aim of proportional representation

    DEFF Research Database (Denmark)

    Lippert-Rasmussen, Kasper

    2008-01-01

    Many organizations, companies, and so on are committed to certain representational aims as regards the composition of their workforce. One motivation for such aims is the assumption that numerical underrepresentation of groups manifests discrimination against them. In this article, I articulate...... representational aims in a way that best captures this rationale. My main claim is that the achievement of such representational aims is reducible to the elimination of the effects of wrongful discrimination on individuals and that this very important concern is, in principle, compatible with the representation...... of discrimination against numerically overrepresented groups, or overlook the innocently different ambitions of some numerically underrepresented groups. In relation to the latter point, I appeal to the fact that many luck egalitarians think justice should be ambition sensitive (but endowment insensitive). Also...

  11. AIM: An Integrated Approach to Organizational Improvement

    Directory of Open Access Journals (Sweden)

    Ronald A. Styron, Jr.

    2016-02-01

    Full Text Available This concept paper is based on the new problem-solving model of Blended Leadership called Alloy Improvement Model (AIM. This model consists of an integration of change theory, leadership theory, and democratic principles and practices to form a comprehensive problem-solving strategy for organizational leaders. The utilization of AIM will assist leaders in moving from problems to solutions while engaging stakeholders in a comprehensive, efficient, inclusive, informative, integrated and transparent process.

  12. Joint force opportunities: Policy Aims And Adaptations

    Science.gov (United States)

    2016-05-26

    meet policy aimed at the survival and prosperity of the nation. The dialog between the policy maker and military adviser requires a broader and deeper...aimed at the survival and prosperity of the nation. The dialog between the policy maker and military adviser requires a broader and deeper...father for feeding a passion for learning with a work ethic ; and your patient love. To D, B, and C: I love you eternally. v

  13. In vitro translocation experiments with RxLR-reporter fusion proteins of Avr1b from Phytophthora sojae and AVR3a from Phytophthora infestans fail to demonstrate specific autonomous uptake in plant and animal cells.

    Science.gov (United States)

    Wawra, Stephan; Djamei, Armin; Albert, Isabell; Nürnberger, Thorsten; Kahmann, Regine; van West, Pieter

    2013-05-01

    Plant-pathogenic oomycetes have a large set of secreted effectors that can be translocated into their host cells during infection. One group of these effectors are the RxLR effectors for which it has been shown, in a few cases, that the RxLR motif is important for their translocation. It has been suggested that the RxLR-leader sequences alone are enough to translocate the respective effectors into eukaryotic cells through binding to surface-exposed phosphoinositol-3-phosphate. These conclusions were primary based on translocation experiments conducted with recombinant fusion proteins whereby the RxLR leader of RxLR effectors (i.e., Avr1b from Phytophthora sojae) were fused to the green fluorescent protein reporter-protein. However, we failed to observe specific cellular uptake for a comparable fusion protein where the RxLR leader of the P. infestans AVR3a was fused to monomeric red fluorescent protein. Therefore, we reexamined the ability of the reported P. sojae AVR1b RxLR leader to enter eukaryotic cells. Different relevant experiments were performed in three independent laboratories, using fluorescent reporter fusion constructs of AVR3a and Avr1b proteins in a side-by-side comparative study on plant tissue and human and animal cells. We report that we were unable to obtain conclusive evidence for specific RxLR-mediated translocation.

  14. Discrimination and the aim of proportional representation

    DEFF Research Database (Denmark)

    Lippert-Rasmussen, Kasper

    2008-01-01

    representational aims in a way that best captures this rationale. My main claim is that the achievement of such representational aims is reducible to the elimination of the effects of wrongful discrimination on individuals and that this very important concern is, in principle, compatible with the representation...... of discrimination against numerically overrepresented groups, or overlook the innocently different ambitions of some numerically underrepresented groups. In relation to the latter point, I appeal to the fact that many luck egalitarians think justice should be ambition sensitive (but endowment insensitive). Also...

  15. To Conclude: India can aim big

    Indian Academy of Sciences (India)

    ... Transmission and Distribution Losses. If 100 million middle class homes deploy 1 kW on rooftops. 100 GW peak power capacity added at homes alone; 40% of current peak power installed in India today. India must aim by 2030. To have 50% of its electric power from SOLAR; To have 50% of vehicles as Electric Vehicles ...

  16. Pragmatics and the aims of language evolution.

    Science.gov (United States)

    Scott-Phillips, Thomas C

    2017-02-01

    Pragmatics has historically played a relatively peripheral role in language evolution research. This is a profound mistake. Here I describe how a pragmatic perspective can inform language evolution in the most fundamental way: by making clear what the natural objects of study are, and hence what the aims of the field should be.

  17. CURRICULUM MATTERS: Aims assessments and workplace needs

    Science.gov (United States)

    Black, Paul

    1997-09-01

    This paper attempts to consider the aims that undergraduate physics degree courses actually reflect and serve in the light of the employment patterns of graduates and of the expressed needs of employers. It reviews the results of analyses of what degree examinations actually test, and goes on to quote criticisms of their courses and radical proposals to change them adopted by the UK conference of physics professors. The discussion is then broadened by discussion of evidence, about the employment of graduates and about the priorities that some industrialists now give in the qualities that they look for when recruiting new graduates. The evidence leads to a view that radical changes are needed, both in courses and examinations, and that there is a need for university departments to work more closely with employers in re-formulating the aims and priorities in their teaching.

  18. Rifkin takes aim at USDA animal research.

    Science.gov (United States)

    Fox, Jeffrey L

    1984-10-19

    Jeremy Rifkin has filed a lawsuit to block U.S. Department of Agriculture (USDA) experiments involving the transfer of human growth hormone genes into sheep and pigs, which he rejects on environmental, economic, and ethical grounds. His real target is the Department's animal breeding program; his ultimate aim is "to establish the principle that there should be no crossing of species barriers in animals." USDA officials have not yet responded to the lawsuit but they intend to continue the experiments, which they consider crucial to the progress of research, until told to stop.

  19. User gains and PD aims

    DEFF Research Database (Denmark)

    Bossen, Claus; Dindler, Christian; Iversen, Ole Sejer

    2010-01-01

    We present a study of user gains from their participation in a participatory design (PD) project at Danish primary schools. We explore user experiences and reported gains from the project in relation to the multiple aims of PD, based on a series of interviews with pupils, teachers, administrators...... relationships among people, stretching across organizations and project groups. Moreover, we demonstrate how users' gains related to their acting within these networks. These results suggest a heightened focus on the indirect and distributed channels through which the long-term impact of PD emerges....

  20. Preceding movement effects on sequential aiming.

    Science.gov (United States)

    Cheng, Darian T; De Grosbois, John; Smirl, Jonathan; Heath, Matthew; Binsted, Gordon

    2011-11-01

    In this study, two experiments were devised to examine the control strategy used by individuals when performing sequential aiming movements. Of particular interest was the aiming behavior displayed when task difficulty was changed midway through a sequence of movements. In Experiment 1, target size was manipulated, as the targets were made either larger or smaller, between the 8th and 12th movement of the sequence. In Experiment 2, the amplitude between the two targets was similarly changed while the target size remained constant. Results revealed that in Experiment 1, individuals took two movements following the perturbation to target size, to re-tune their movement times in order to correspond with the new task difficulty. Conversely for Experiment 2, movement time changed immediately and in correspondence with the new target amplitude. These findings demonstrate that participants can use information from the preceding movement to prepare and guide subsequent movements--but only when target size is changed. When response amplitude changes mid-sequence, it seems individuals rely more on immediate, target-derived information. Therefore, counter to some current accounts of visual movement control, it appears that memory representations of the preceding movement can guide subsequent movements; however, this information appears selectively accessed in a context-dependent fashion.

  1. AIM cryocooler developments for HOT detectors

    Science.gov (United States)

    Rühlich, I.; Mai, M.; Withopf, A.; Rosenhagen, C.

    2014-06-01

    Significantly increased FPA temperatures for both Mid Wave and Long Wave IR detectors, i.e. HOT detectors, which have been developed in recent years are now leaving the development phase and are entering real application. HOT detectors allowing to push size weight and power (SWaP) of Integrated Detectors Cooler Assemblies (IDCA's) to a new level. Key component mainly driving achievable weight, volume and power consumption is the cryocooler. AIM cryocooler developments are focused on compact, lightweight linear cryocoolers driven by compact and high efficient digital cooler drive electronics (DCE) to also achieve highest MTTF targets. This technology is using moving magnet driving mechanisms and dual or single piston compressors. Whereas SX030 which was presented at SPIE in 2012 consuming less 3 WDC to operate a typical IDCA at 140K, next smaller cooler SX020 is designed to provide sufficient cooling power at detector temperature above 160K. The cooler weight of less than 200g and a total compressor length of 60mm makes it an ideal solution for all applications with limited weight and power budget, like in handheld applications. For operating a typical 640x512, 15μm MW IR detector the power consumption will be less than 1.5WDC. MTTF for the cooler will be in excess of 30,000h and thus achieving low maintenance cost also in 24/7 applications. The SX020 compressor is based on a single piston design with integrated passive balancer in a new design achieves very low exported vibration in the order of 100mN in the compressor axis. AIM is using a modular approach, allowing the chose between 5 different compressor types for one common Stirling expander. The 6mm expander with a total length of 74mm is now available in a new design that fits into standard dewar bores originally designed for rotary coolers. Also available is a 9mm coldfinger in both versions. In development is an ultra-short expander with around 35mm total length to achieve highest compactness. Technical

  2. Plasma health care - Aims, constraints and progress

    International Nuclear Information System (INIS)

    Morfill, G.E.; Zimmerman, J.L.

    2013-01-01

    Health Care covers three areas of interest for cold atmospheric pressure plasmas: Cosmetics, Hygiene and Medicine. These areas can be subdivided into personal and professional care. In this review will concentrate on Hygiene and Medicine. In professional hygiene the most important plasma contribution is sterilization, decontamination and disinfection. The main aim is the prevention of diseases or their containment. Progress in the development of efficient bactericidal plasma sources has been rapid, so that it appears realistic to use plasmas to combat nosocomial infections as well as community associated infections in the not too distant future. The advantages of plasma devices – they use air and electricity only, there are no waste products, they are inexpensive to manufacture and operate, easy to transport and install, and bactericidal effects are fast (seconds). Plasmas can efficiently kill resistant bacteria (e.g. MRSA) and tests have shown no resistance build-up so far. With an estimated 2 Million hospital induced infections each year in the US alone, and about 100.000 resulting deaths, very efficient, safe and fast hospital plasma hygiene devices would appear to be a very important weapon to help contain the spread of infectious diseases. In Medicine there are a number of ambitious ideas and aims. Plasmas can be “designed” to some extent. They can include different active species that can have an effect at the cellular level. There are ionic atoms and molecules, whose medical use need to be evaluated – the vision is that a new area of “plasma pharmacy” could develop. First steps are currently being taken in biological studies. Also the excited atoms in cold atmospheric plasmas may make cell walls more permeable for such species. (author)

  3. On correlations in IMRT planning aims

    Science.gov (United States)

    Roy, Arkajyoti; Das, Indra J.

    2016-01-01

    The purpose was to study correlations amongst IMRT DVH evaluation points and how their relaxation impacts the overall plan. 100 head‐and‐neck cancer cases, using the Eclipse treatment planning system with the same protocol, are statistically analyzed for PTV, brainstem, and spinal cord. To measure variations amongst the plans, we use (i) interquartile range (IQR) of volume as a function of dose, (ii) interquartile range of dose as a function of volume, and (iii) dose falloff. To determine correlations for institutional and ICRU goals, conditional probabilities and medians are computed. We observe that most plans exceed the median PTV dose (average D50 = 104% prescribed dose). Furthermore, satisfying D50 reduced the probability of also satisfying D98, constituting a negative correlation of these goals. On the other hand, satisfying D50 increased the probability of satisfying D2, suggesting a positive correlation. A positive correlation is also observed between the PTV V105 and V110. Similarly, a positive correlation between the brainstem V45 and V50 is measured by an increase in the conditional median of V45, when V50 is violated. Despite the imposed institutional and international recommendations, significant variations amongst DVH points can occur. Even though DVH aims are evaluated independently, sizable correlations amongst them are possible, indicating that some goals cannot be satisfied concurrently, calling for unbiased plan criteria. PACS number(s): 87.55.dk, 87.53.Bn, 87.55.Qr, 87.55.de. PMID:27929480

  4. Taking aim at novel vaccines market.

    Science.gov (United States)

    Awasthi, Sita

    2009-10-01

    The World Vaccine Congress Washington 2009 was held in Chantilly, VA USA April 2O -23rd. The Vaccine congress attracted over 400 participants from across the world, including leading vaccine manufacturers, biotechs, governmental agencies, NGOs, research and academic institutes, venture capital and legal firms, contract service and equipment manufacturers. The speakers covered a wide range of topics, including the role of government and regulatory agencies, funding availability, research and development, manufacturing, packaging and post vaccine evaluations. Past vaccine development efforts have historically focused on infectious diseases. With advancements in the field of immunology, molecular biology and vaccinology, the vaccine field has begun moving in new directions. "Taking aim at novel vaccines market" session chaired by Dr. Una Ryan, Chief Executive Officer of Waltham Technologies, was focused on traditional approaches to novel targets (nosocomial infections), novel approaches to traditional targets (flu and rabies), novel approaches to novel targets (Type 1 diabetes, multiple sclerosis and smoking) and vaccines for developing markets (TB, malaria, rabies). The importance of collaborations among academic institutions, industries, and philanthropic foundations for developing markets was also emphasized.

  5. Circulating AIM Prevents Hepatocellular Carcinoma through Complement Activation

    Directory of Open Access Journals (Sweden)

    Natsumi Maehara

    2014-10-01

    Full Text Available Hepatocellular carcinoma (HCC is a widespread fatal disease and the third most common cause of cancer deaths. Here, we show the potent anti-HCC effect of the circulating protein AIM. As in adipocytes, AIM is incorporated into normal hepatocytes, where it interferes with lipid storage. In contrast, AIM accumulates on the HCC cell surface and activates the complement cascade via inactivating multiple regulators of complement activation. This response provokes necrotic cell death specifically in AIM-bound HCC cells. Accordingly, AIM−/− mice were highly susceptible to steatosis-associated HCC development, whereas no AIM+/+ mouse developed the disease despite comparable liver inflammation and fibrosis in response to a long-term high-fat diet. Administration of AIM prevented tumor development in AIM−/− mice, and HCC induction by diethylnitrosamine was more prominent in AIM−/− than wild-type mice. These findings could be the basis for novel AIM-based therapeutic strategies for HCC.

  6. Especificidades de usuários(as de drogas visando uma assistência baseada na heterogeneidade Especificidades de usuários (as de drogas visando una asistencia basada en la heterogeneidad Drug users' specifics aiming the assistance based in the heterogeneity

    Directory of Open Access Journals (Sweden)

    Jeane Freitas de Oliveira

    2007-12-01

    deals with the issue of heterogeneity in drug addicted groups/people, emphasizing women's specifics. A concise survey of the literature on drugs phenomenon and health of works reporting the use of gender as an empiric variable is presented. Differences were found in drug consumption habits between men and women. Moreover, women's habits were shown to be influenced by specifics regarding both epidemiologic aspects and socio cultural elements. The main gender differences were observed on consumption rate, kind of drug, age, mortality and comorbidity. Concerning women groups, the main differences were found relating both kind of drug versus age and treatment seek versus kind of activity developed in the health unit. Examination of the data leads to the conclusion that assistance to drug users should take specifics of groups/people into account.

  7. DNA methylation and gene expression of HIF3A

    DEFF Research Database (Denmark)

    Main, Ailsa Maria; Gillberg, Linn; Jacobsen, Anna Louisa

    2016-01-01

    BACKGROUND: Associations between BMI and DNA methylation of hypoxia-inducible factor 3-alpha (HIF3A) in both blood cells and subcutaneous adipose tissue (SAT) have been reported. In this study, we investigated associations between BMI and HIF3A DNA methylation in the blood and SAT from the same...... individuals, and whether HIF3A gene expression in SAT and skeletal muscle biopsies showed associations with BMI and insulin resistance. Furthermore, we aimed to investigate gender specificity and heritability of these traits. METHODS: We studied 137 first-degree relatives of type 2 diabetes (T2D) patients...... glucose tolerance tests. RESULTS: BMI was associated with HIF3A methylation at one CpG site in the blood, and there was a positive association between the blood and SAT methylation levels at a different CpG site within the individuals. The SAT methylation level did not correlate with HIF3A gene expression...

  8. Develop draft chip seal cover aggregate specification based on AIMS angularity, shape and texture test results.

    Science.gov (United States)

    2013-03-01

    The objective of the study is to improve Oklahoma Department of Transportation (ODOT) chip : seal design and performance through introducing new criteria for the selection of cover : aggregate and binder. These criteria will be based upon the recent ...

  9. An intervention aimed at reducing plagiarism in undergraduate nursing students.

    Science.gov (United States)

    Smedley, Alison; Crawford, Tonia; Cloete, Linda

    2015-05-01

    Plagiarism is a current and developing problem in the tertiary education sector where students access information and reproduce it as their own. It is identified as occurring in many tertiary level degrees including nursing and allied health profession degrees. Nursing specifically, is a profession where standards and ethics are required and honesty is paramount. The aim of this study was to evaluate the change in nursing student's knowledge and understanding of plagiarism before and after an educational intervention in their first semester of the Bachelor of nursing degree at a private college of higher education in Sydney, Australia. This study concluded that an educational intervention can increase knowledge and awareness of plagiarism among nursing students. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Student Teachers’ Attitude towards Twitter for Educational Aims

    Directory of Open Access Journals (Sweden)

    Victoria I. Marín

    2014-07-01

    Full Text Available This paper presents an educational experience with 100 student teachers from different courses of the University of the Balearic Islands (Spain in which Twitter is used for various different activities. The aim of this experiment was to explore student teachers’ perceptions in order to value their attitude towards Twitter for educational aims. Afterwards, students were asked to write down their reflections on an eportfolio. Data was collected from their eportfolio evidence, which was analysed to review their attitude towards the use of Twitter for educational purposes and for their future teaching and professional development. The conclusions indicate the need to conduct different educational activities in which Twitter is used in various ways. In addition, conclusions reflect on the real impact of Twitter on students’ learning enhancement, in order to improve student teachers’ attitudes towards social media in education. Therefore, this article contributes to the body of existing research on the use of technology in education, specifically to the possibilities of the use of social media and microblogging in Teacher Education.

  11. Measuring the "triple aim" in transition care: a systematic review.

    Science.gov (United States)

    Prior, Megan; McManus, Margaret; White, Patience; Davidson, Laurie

    2014-12-01

    Without adequate support, adolescents transitioning from the pediatric to the adult health care system are at increased risk for poor health outcomes. Numerous interventions attempt to improve this transition, yet few comprehensively evaluate efficacy. To advance evaluation methods and ultimately the quality of transition services, it is necessary to understand the current state of health care transition measurement. This study examines and categorizes transition measures by using the "Triple Aim" framework of experience of care, population health, and cost of care. Ovid Medline and the Cumulative Index to Nursing and Allied Health Literature were searched for articles published between 1995 and 2013. Two reviewers independently screened studies and included those that evaluated the impact of a health care transition intervention. Measures were subsequently classified according to population health, experience of care, and costs of care. Of the 2282 studies initially identified, 33 met inclusion criteria. Population health measures were used in 27 studies, with disease-specific measures collected most frequently. Fifteen studies measured cost, most often service utilization. Eight studies measured experience of care, with satisfaction assessed most commonly. Only 3 studies examined all 3 domains of the "Triple Aim." Transition interventions described in the gray literature were not reviewed. Transition programs are inconsistently evaluated in terms of their impact on population health, patient experience, and cost. To demonstrate improvement in the transition from pediatric to adult health care, a more robust and consistent set of measures is needed. Copyright © 2014 by the American Academy of Pediatrics.

  12. Ube3a

    Science.gov (United States)

    Wallace, Michael L; van Woerden, Geeske M; Elgersma, Ype; Smith, Spencer L; Philpot, Benjamin D

    2017-07-01

    Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of the maternally inherited allele of UBE3A Ube3a STOP/p+ mice recapitulate major features of AS in humans and allow conditional reinstatement of maternal Ube3a with the expression of Cre recombinase. We have recently shown that AS model mice exhibit reduced inhibitory drive onto layer (L)2/3 pyramidal neurons of visual cortex, which contributes to a synaptic excitatory/inhibitory imbalance. However, it remains unclear how this loss of inhibitory drive affects neural circuits in vivo. Here we examined visual cortical response properties in individual neurons to explore the consequences of Ube3a loss on intact cortical circuits and processing. Using in vivo patch-clamp electrophysiology, we measured the visually evoked responses to square-wave drifting gratings in L2/3 regular-spiking (RS) neurons in control mice, Ube3a -deficient mice, and mice in which Ube3a was conditionally reinstated in GABAergic neurons. We found that Ube3a -deficient mice exhibited enhanced pyramidal neuron excitability in vivo as well as weaker orientation tuning. These observations are the first to show alterations in cortical computation in an AS model, and they suggest a basis for cortical dysfunction in AS. NEW & NOTEWORTHY Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of the gene UBE3A Using electrophysiological recording in vivo, we describe visual cortical dysfunctions in a mouse model of AS. Aberrant cellular properties in AS model mice could be improved by reinstating Ube3a in inhibitory neurons. These findings suggest that inhibitory neurons play a substantial role in the pathogenesis of AS. Copyright © 2017 the American Physiological Society.

  13. Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes Cell Proliferation and Motility in Pancreatic Cancer.

    Science.gov (United States)

    Wang, Shu Qian; Liu, Yu; Yao, Min Ya; Jin, Jing

    2016-10-01

    Identifying a target molecule that is crucially involved in pancreatic tumor growth and metastasis is necessary in developing an effective treatment. The study aimed to investigate the role of the eukaryotic translation initiation factor 3a (eIF3a) in the cell proliferation and motility in pancreatic cancer. Our data showed that the expression of eIF3a was upregulated in pancreatic ductal adenocarcinoma as compared with its expression in normal pancreatic tissues. Knockdown of eIF3a by a specific shRNA caused significant decreases in cell proliferation and clonogenic abilities in pancreatic cancer SW1990 and Capan-1 cells. Consistently, the pancreatic cancer cell growth rates were also impaired in xenotransplanted mice. Moreover, wound-healing assay showed that depletion of eIF3a significantly slowed down the wound recovery processes in SW1990 and Capan-1 cells. Transwell migration and invasion assays further showed that cell migration and invasion abilities were significantly inhibited by knockdown of eIF3a in SW1990 and Capan-1 cells. Statistical analysis of eIF3a expression in 140 cases of pancreatic ductal adenocarcinoma samples revealed that eIF3a expression was significantly associated with tumor metastasis and TNM staging. These analyses suggest that eIF3a contributes to cell proliferation and motility in pancreatic ductal adenocarcinoma.

  14. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist.

    Science.gov (United States)

    Raufman, J P; Singh, L; Eng, J

    1991-02-15

    Exendin-3 increased cellular cAMP levels and amylase release from dispersed acini from guinea pig pancreas. Low concentrations (0.1-3 nM) caused a 12-fold increase in cAMP, whereas higher concentrations (0.3-3 microM) caused an additional 24-fold increase in cAMP. Maximal cAMP with the highest concentration tested was the same as the maximal response with secretin, vasoactive intestinal peptide (VIP), peptide histidine isoleucine, helodermin, or helospectin-I. In terms of amylase release, exendin-3 had the same efficacy but was the least potent of these peptides. Exendin-3-induced increases in amylase release were inhibited by VIP receptor antagonists and the new peptide (greater than 0.1 microM) competed with radiolabeled VIP for binding sites on dispersed acini. Increasing concentrations of an exendin-3 fragment, exendin-3(9-39) amide, did not increase cAMP or amylase release but inhibited the increase in cAMP observed with 0.1-3 nM exendin-3. The fragment did not alter the effects of other peptides that are known to increase acinar cAMP. We conclude that exendin-3 interacts with at least two receptors on guinea pig pancreatic acini; at high concentrations (greater than 100 nM) the peptide interacts with VIP receptors, thereby causing a large increase in cAMP and stimulating amylase release; at lower concentrations (0.1-3 nM) the peptide interacts with a putative exendin receptor, thereby causing a smaller increase in cAMP of undetermined function. Exendin-3(9-39) amide is a specific exendin receptor antagonist.

  15. MATLAB 3A

    DEFF Research Database (Denmark)

    Freil, Ole; Kristiansen, Heidi; Kaas, Thomas

    MATLAB 3a – Matematiklaboratoriet er en elevbog til første halvdel af 3. klasse. Bogen indeholder fire kapitler: 'Store tal og regnemåder', 'Kan du tegne det?', 'Gange og division', 'Undersøg data og chance'.......MATLAB 3a – Matematiklaboratoriet er en elevbog til første halvdel af 3. klasse. Bogen indeholder fire kapitler: 'Store tal og regnemåder', 'Kan du tegne det?', 'Gange og division', 'Undersøg data og chance'....

  16. [Social marketing--seduction with the aim of healthy behavior?].

    Science.gov (United States)

    Loss, J; Nagel, E

    2010-01-01

    SOCIAL MARKETING - SEDUCTION WITH THE AIM OF HEALTHY BEHAVIOR? Social marketing is the use of marketing principles to design and implement programs that promote socially beneficial behaviour change. Contrary to the marketing of consumption goods, social marketing does not deal with material products, but with behaviour, e. g. not smoking. This 'product' has a basic benefit (i. e. reduction of health risks in the long run), which is, however, difficult to convey. Therefore, the intended change in behaviour has to be related to a further reward which consists of symbolic goods, e. g. social appreciation or a better body feeling. The communication policy is essential for information on and motivation for the preventive issue. Social marketing campaigns whose development and management follow the principles of classical marketing can render preventive efforts more effective. In addition, social marketing can lead to a better quality management as compared to conventional preventive activities. These advantages can be explained by a) tailoring the campaign more specifically to the target group's needs and motives, b) presenting health risks more convincingly, and c) continuously analysing and evaluating the campaign and its effects. On the other hand, the marketing of preventive aims through mass media can bear several risks, as exemplified by different national and international public health campaigns. The necessity to communicate briefly and succinctly can lead to misleading simplifications and, in case of cancer screening, to the trivialization of a behaviour's consequences and adverse effects. Also, many campaigns do not intend to educate and inform, but try to persuade target persons of a certain behaviour, using emotions such as fear. This has led to social marketing being criticized as manipulation. Sometimes, social marketing campaigns cause stigma and discrimination of certain population subgroups, e. g. obese or HIV-positive people. Health promoters who plan

  17. Association of CYP3A4 and CYP3A5 polymorphisms with Iranian ...

    African Journals Online (AJOL)

    Abstract. Background: Polymorphisms of different gene have been reported to be associated with cancer including breast cancer. Hospitalization rate for breast cancer has increased over the years in Iran. Aim: The aim of this study was to examine whether polymorphisms in the CYP3A4 and. CYP3A5 genes affect the risk of ...

  18. Interventions aiming to reduce early retirement due to rheumatic diseases

    Directory of Open Access Journals (Sweden)

    Pedro Almeida Laires

    2017-07-01

    Full Text Available Introduction: Aging of the population and early retirement translates into productivity losses to society. Persistence of working life is crucial to counteract this sustainability issue faced by western countries. Musculoskeletal and rheumatic diseases (RD may cause work disability and early exit from work, including early retirement. The objective of this article is to review the current knowledge about interventions aiming to reduce early retirement due to RD. Methods: We searched PubMed and The Cochrane Library for studies either in English or Portuguese between January 2000 and June 2016 that evaluated the impact of interventions targeting early retirement in RD patients still at work. We also searched for grey literature from Portuguese institutional repositories. Results: We identified several published studies testing pharmacologic and non-pharmacologic vocational rehabilitation interventions. None was specifically identified for Portugal. The general low quality of the literature and its inconsistency makes it unfeasible to draw definitive conclusions. However, some broad recommendations might be outlined. An effective intervention must: 1 act upon different levels (e.g. RD patient, workplace, involving several stakeholders (e.g. rheumatologists, occupational physicians, employers; 2 prioritize the right patients (e.g. more disabling RD; and 3 consider the patients’ role, for instance by including an element of patient education and support. Despite the lack of good quality evidence on this field, there seems to be a growing interest in the international scientific community with several ongoing studies promoting such interventions. This promising data will be very useful to set up effective policies. Conclusions: This article summarizes the current knowledge about the impact of interventions to avoid or mitigate early retirement in RD patients. It highlights the demand for further research and it also contributes to aware decision

  19. Automated Instructional Management Systems (AIMS) Version III, System Manual.

    Science.gov (United States)

    New York Inst. of Tech., Old Westbury.

    This document sets forth the procedures necessary to understand and utilize the internal characteristics of the Automated Instructional Management System (AIMS), a computer-based system for the management of educational processes. In this manual, overall design concepts governing the development of AIMS are specified; and overview of its…

  20. Refractive aim and visual outcome after phacoemulsification: A 2 ...

    African Journals Online (AJOL)

    2016-03-24

    Mar 24, 2016 ... Aim: To review the short‑term visual outcome of phacoemulsification in adults with uncomplicated cataracts in Eye. Foundation Hospital ... aim, intraoperative complications, postoperative unaided, and best‑corrected visual acuity at 1 and 3 months were analyzed. ..... Financial support and sponsorship. Nil.

  1. Teaching Design Education for Cultural, Pedagogical, and Economic Aims

    Science.gov (United States)

    Vande Zande, Robin

    2010-01-01

    The aims of educating for economic, cultural, and pedagogical purposes have existed since the early inception of art education. Looking at how and why these aims evolved in the early era of art and design education has potential for better understanding how and why design should be incorporated into the art education curricula today. This article…

  2. Student Teachers' Attitude towards Twitter for Educational Aims

    Science.gov (United States)

    Marín, Victoria I.; Tur, Gemma

    2014-01-01

    This paper presents an educational experience with 100 student teachers from different courses of the University of the Balearic Islands (Spain) in which Twitter is used for various different activities. The aim of this experiment was to explore student teachers' perceptions in order to value their attitude towards Twitter for educational aims.…

  3. The Aims of Education and the Leap of Freedom

    Science.gov (United States)

    Yun, SunInn

    2014-01-01

    This paper considers the place of freedom in discussions of the aims of education. Bearing in mind remarks of R.S. Peters to the affect that the singling out of aims can "fall into the hands of rationalistically minded curriculum planners", it begins by considering the views of Roland Reichenbach regarding Bildung and his account of this…

  4. Found in Translation: Interdisciplinary Arts Integration in Project AIM

    Science.gov (United States)

    Pruitt, Lara; Ingram, Debra; Weiss, Cynthia

    2014-01-01

    This paper will share the arts-integration methodology used in Project AIM and address the question; "How is translation evident in interdisciplinary arts instruction, and how does it affect students?" Methods: The staff and researchers from Project AIM, (an arts-integration program of the Center for Community Arts Partnerships at…

  5. The compatibility between extension aims of staff and their ...

    African Journals Online (AJOL)

    This pilot investigation was done to investigate the compatibility between extension aims of extension staff and those of their employer. It shows that only 50 percent of respondents have an acceptable understanding of the official aims (vision), and that none of the components of the official vision has sufficient compatibility ...

  6. Selection patterns, gender and friendship aim in classroom networks.

    NARCIS (Netherlands)

    Baerveldt, Chris; Van de Bunt, Gerhard G.; Vermande, Marjolijn M.

    2014-01-01

    The social networks of students, and the underlying processes of selection, can have strong effects on their psychological and academic adjustment. The effects of gender, friendship aim (intimacy or social activities) and the combination of gender and friendship aim on selection patterns (student’s

  7. The Asteroid Impact Mission - Deflection Demonstration (AIM - D2)

    Science.gov (United States)

    Küppers, M.; Michel, P.; Carnelli, I.

    2017-09-01

    The Asteroid Impact Mission (AIM) is ESA's contribution to the international Asteroid Impact Deflection Assessment (AIDA) cooperation, targeting the demonstration of deflection of a hazardous near-earth asteroid. AIM will also be the first in-depth investigation of a binary asteroid and make measurements that are relevant for the preparation of asteroid resource utilisation. AIM is foreseen to rendezvous with the binary near-Earth asteroid (65803) Didymos and to observe the system before, during, and after the impact of NASA's Double Asteroid Redirection Test (DART) spacecraft. Here we describe the observations to be done by the simplified version Asteroid Impact Mission - Deflection Demonstration (AIM-D2) and show that most of the original AIM objectives can still be achieved.

  8. Predicting Intersystem Crossing Rates with AIMS-DFT Molecular Dynamics.

    Science.gov (United States)

    Fedorov, Dmitry A; Lykhin, Aleksandr O; Varganov, Sergey A

    2018-03-23

    Accurate prediction of the intersystem crossing rates is important for many different applications in chemistry, physics, and biology. Recently, we implemented the ab initio multiple spawning (AIMS) molecular dynamics method to describe the intersystem crossing processes, where nonradiative transitions between electronic states with different spin multiplicities are mediated by spin-orbit coupling. Our original implementation of the direct AIMS dynamics used the complete active space self-consistent field (CASSCF) method to describe multiple coupled electronic states on which multidimensional Gaussian wave packets were propagated. In this work, we improve the computational efficiency and versatility of the AIMS dynamics by interfacing it with the density functional theory (DFT). The new AIMS-DFT and the earlier AIMS-CASSCF implementations are used to investigate the effects of electronic structure methods on the predicted intersystem crossing rate constants and the lowest triplet state lifetime in the GeH 2 molecule. We also compare the rates and lifetimes obtained from the AIMS simulations with those predicted by the statistical nonadiabatic transition state theory (NA-TST). In NA-TST, the probabilities of spin transitions are calculated using the Landau-Zener, weak coupling, and Zhu-Nakamura formulas. Convergence of the AIMS rate constants with respect to the simulation time and the number of initial trajectories (Gaussian wave packets) is analyzed. An excellent agreement between AIMS-DFT and AIMS-CASSCF can be explained by cancelation of two effects: higher energy barriers and a stronger spin-orbit coupling in DFT relative to CASSCF. The rate constants obtained with the AIMS-DFT dynamics are about a factor of 2 larger than those predicted by the statistical NA-TST. This is likely due to the importance of the nonlocal interstate transitions missing from the NA-TST description.

  9. Implementation of an Anesthesia Information Management System (AIMS).

    Science.gov (United States)

    Douglas, James R; Ritter, Melody J

    2011-01-01

    During the administration of anesthesia, the anesthesia provider has historically created a paper record, charted manually, that included extensive patient care-related data (vital signs, other parameters, etc) and commentaries. DocuSys, a proprietary anesthesia information management system (AIMS), creates an electronic version of the anesthesia record and provides additional information. It electronically captures data from clinical monitors and other sources, including scheduling applications and laboratory computers. The AIMS facilitates chart entries such as drug doses and case narratives. Benefits of an AIMS include improved legibility of the anesthesia record and greater efficiency in documentation efforts. Use of the AIMS assists the practitioner with decision support logic, such as the timing of antibiotic administration and the inclusion of legally required documentation. Upon case completion, the AIMS data are immediately available to other information systems, such as billing and medical records. Data can be made available from a single case or, more important, from thousands of cases to analyze variables such as efficiency of services, adherence to best practices, patient outcomes, and clinical research. The AIMS was deployed at the main campus of the Ochsner Health System on March 26, 2009. In this article, we discuss the issues involved in the AIMS implementation process: the successes, surprises, and continued challenges.

  10. A review of intervention studies aimed at household energy conservation

    NARCIS (Netherlands)

    Abrahamse, W; Steg, L; Vlek, C; Rothengatter, T; Rothengatter, J.A.

    This article reviews and evaluates the effectiveness of interventions aiming to encourage households to reduce energy consumption. Thirty-eight studies performed within the field of (applied) social and environmental psychology are reviewed, and categorized as involving either antecedent strategies

  11. Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome

    Directory of Open Access Journals (Sweden)

    Deborah D Crane

    2014-08-01

    Full Text Available Activation of the inflammasome is important for the detection and clearance of cytosolic pathogens. In contrast to avirulent F. novicida (Fn, infection with virulent F. tularensis ssp tularensis does not trigger activation of the host AIM2 inflammasome. Here we show that differential activation of AIM2 following Francisella infection is due to sensitivity of each isolate to reactive oxygen species (ROS. ROS present at the outset of Fn infection contributes to activation of the AIM2 inflammasome, independent of NLRP3 and NADPH oxidase. Rather, mitochondrial ROS (mROS is critical for Fn stimulation of the inflammasome. This study represents the first demonstration of the importance of mROS in the activation of the AIM2 inflammasome by bacteria. Our results also demonstrate that bacterial resistance to mROS is a mechanism of virulence for early evasion of detection by the host.

  12. Psychoneuroendocrine interventions aimed at attenuating immunosenescence: a review

    NARCIS (Netherlands)

    Bauer, M.E.; Muller, G.C.; Correa, B.L.; Vianna, P.; Turner, J.E.; Bosch, J.A.

    2013-01-01

    There is evidence suggesting that immunosenescence can be accelerated by external factors such as chronic stress. Here we review potential psychoneuroendocrine determinants of premature aging of the immune system and discuss available interventions aimed at attenuating immunosenescence. Chronic

  13. Americans aim to overhaul science teaching by 2061

    CERN Multimedia

    1990-01-01

    Project 2061 is a long-term initiative by the AAAS to reform classroom science. Deputy director Walter Gillespie claims that the aim is for schools to teach less content but teach it better (1/2 page).

  14. Toolkit for local decision makers aims to strengthen environmental sustainability

    CSIR Research Space (South Africa)

    Murambadoro, M

    2011-11-01

    Full Text Available Members of the South African Risk and Vulnerability Atlas were involved in a meeting aimed at the development of a toolkit towards improved integration of climate change into local government's integrated development planning (IDP) process....

  15. Evaluation and cultural adaptation of a German version of the AIMS2-SF questionnaire (German AIMS2-SF).

    NARCIS (Netherlands)

    Rosemann, T.J.; Korner, T.; Wensing, M.J.P.; Schneider, A.; Szecsenyi, J.

    2005-01-01

    OBJECTIVES: The aim of the study was to examine the validity of a translated and culturally adapted version of the Arthritis Impact Measurement Scales 2, Short Form (AIMS2-SF) in patients suffering from osteoarthritis (OA) in primary care. METHODS: A structured procedure was used for the translation

  16. Ethics and aims in psychotherapy: a contribution from Kant.

    Science.gov (United States)

    Callender, J S

    1998-08-01

    Psychotherapy is an activity which takes many forms and which has many aims. The present paper argues that it can be viewed as a form of moral suasion. Kant's concepts of free will and ethics are described and these are then applied to the processes and outcome of psychotherapy. It is argued that his ideas, by linking rationality, free will and ethics into a single philosophical system, offer a valuable theoretical framework for thinking about aims and ethical issues in psychotherapy.

  17. Uncertainty in aiming movements and its association to hand function

    Directory of Open Access Journals (Sweden)

    Flávia Priscila de Paiva Silva

    2015-09-01

    Full Text Available AbstractThe purpose of this study was to analyze the influence of the uncertainty of target location on the planning and execution of aiming movements performed towards the ipsilateral and contralateral directions by the right and left upper limbs. In addition, the association between the performance of aiming movements and the performance of functional manual tasks was investigated. Two tasks were proposed: with prior knowledge of the movement direction (simple reaction time or not (choice reaction time. The grip strength and manual dexterity were measured. The choice option in response (i.e. uncertainty influenced planning of the aiming movements, but not its execution, while movements performed towards the contralateral direction were worse in execution as compared to the ipsilateral direction. Manual dexterity was significantly correlated with reaction times, while the performance during movement execution was significantly correlated with handgrip/pinch strength.

  18. Provider Burnout and Patient Engagement: The Quadruple and Quintuple Aims.

    Science.gov (United States)

    Epperson, William Jackson; Childs, Susan Fink; Wilhoit, Gordon

    2016-01-01

    The Triple Aim has become the guiding light and benchmark by which healthcare organizations plan their future efforts. It has been adopted into healthcare policies with little regard for including the skill sets of compassion and emotional intelligence. The multiple increasing demands on providers of healthcare are unsustainable and will cripple the system, resulting in outcomes that are counter to the Triple Aim goals. Patient engagement with shared decision-making should become the primary focus of care delivery. New delivery models and care plans are unaffordable to far too many patients and payers, despite the efforts of futurists who seek to advance quality and lower costs. Clinical care delivery and patient engagement efforts must be drastically redirected to innovative and sustainable value-based delivery models that support the goals of the Triple Aim.

  19. The FAST-AIMS Clinical Mass Spectrometry Analysis System

    Directory of Open Access Journals (Sweden)

    Nafeh Fananapazir

    2009-01-01

    Full Text Available Within clinical proteomics, mass spectrometry analysis of biological samples is emerging as an important high-throughput technology, capable of producing powerful diagnostic and prognostic models and identifying important disease biomarkers. As interest in this area grows, and the number of such proteomics datasets continues to increase, the need has developed for efficient, comprehensive, reproducible methods of mass spectrometry data analysis by both experts and nonexperts. We have designed and implemented a stand-alone software system, FAST-AIMS, which seeks to meet this need through automation of data preprocessing, feature selection, classification model generation, and performance estimation. FAST-AIMS is an efficient and user-friendly stand-alone software for predictive analysis of mass spectrometry data. The present resource review paper will describe the features and use of the FAST-AIMS system. The system is freely available for download for noncommercial use.

  20. S3T working group. Report 1: group aims

    International Nuclear Information System (INIS)

    Pouey, M.

    1983-04-01

    The work group S3T which is aimed to designing and developing devices using unconventional holographic optics is presented. These devices find applications that are classified here in four items high resolution spectrometers, high definition imaging, high flux devices, metrology and interferometry. The problems to solve and the aims of the group in each of these cases are presented. Three synthesis of lectures are in this report. The main one concerns stigmatism conditions of concave holographic gratings used in normal incidence. This new process of focusing is very interesting for hot plasma diagnostics [fr

  1. Extracurricular Activities in the Steps of Aim-Based Education

    Directory of Open Access Journals (Sweden)

    Yunus Yildiz

    2017-11-01

    Full Text Available Teachers and students’ competence applying the required steps in learning process takes paramount place depending on the aim-based education. Hence, by this study, it is aimed to enhance the students’ motivation by applying the right learning steps. In addition, this study facilitates teachers’ ability to make a decision about which methods, approaches and stage orders to follow confidently while teaching a foreign language to any learner. Consequently, it is emphasized that quality learning process needs motivation which may be provided by extracurricular activities.

  2. Aims and Formats of performance measurement at Danish Universities

    DEFF Research Database (Denmark)

    Raffnsøe-Møller, Morten

    2011-01-01

    Abstract This article traces the aims and formats of performance measurement of Danish Universities as they originate from the Ministry of Finance’s plan for governance of the public sector. The article further show that the fierce conflicts between central administration and the universities over...... these performance initiatives are due to two main factors: A clash between external and internal regimes of performance management and a conflict over the interpretation of the overall aims of the university. A distinction between three Performance management paradigms – target regimes, ranking regimes...

  3. Advanced Industrial Materials (AIM) Program annual progress report, FY 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-05-01

    The Advanced Industrial Materials (AIM) Program is a part of the Office of Industrial Technologies (OIT), Energy Efficiency and Renewable Energy, US Department of Energy (DOE). The mission of AIM is to support development and commercialization of new or improved materials to improve energy efficiency, productivity, product quality, and reduced waste in the major process industries. OIT has embarked on a fundamentally new way of working with industries--the Industries of the Future (IOF) strategy--concentrating on the major process industries that consume about 90% of the energy and generate about 90% of the waste in the industrial sector. These are the aluminum, chemical, forest products, glass, metalcasting, and steel industries. OIT has encouraged and assisted these industries in developing visions of what they will be like 20 or 30 years into the future, defining the drivers, technology needs, and barriers to realization of their visions. These visions provide a framework for development of technology roadmaps and implementation plans, some of which have been completed. The AIM Program supports IOF by conducting research and development on materials to solve problems identified in the roadmaps. This is done by National Laboratory/industry/university teams with the facilities and expertise needed to develop new and improved materials. Each project in the AIM Program has active industrial participation and support.

  4. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.

    Science.gov (United States)

    Dang, Eric V; McDonald, Jeffrey G; Russell, David W; Cyster, Jason G

    2017-11-16

    Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription factors. However, the molecular links between lipid metabolism and IL-1β production remain obscure. Here, we demonstrate that production of 25-hydroxycholesterol (25-HC) by macrophages is required to prevent inflammasome activation by the DNA sensor protein absent in melanoma 2 (AIM2). We find that in response to bacterial infection or lipopolysaccharide (LPS) stimulation, macrophages upregulate Ch25h to maintain repression of SREBP2 activation and cholesterol synthesis. Increasing macrophage cholesterol content is sufficient to trigger IL-1β release in a crystal-independent but AIM2-dependent manner. Ch25h deficiency results in cholesterol-dependent reduced mitochondrial respiratory capacity and release of mitochondrial DNA into the cytosol. AIM2 deficiency rescues the increased inflammasome activity observed in Ch25h -/- . Therefore, activated macrophages utilize 25-HC in an anti-inflammatory circuit that maintains mitochondrial integrity and prevents spurious AIM2 inflammasome activation. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Furthering the aim of multi-lingualism through integrated terminology ...

    African Journals Online (AJOL)

    This article aims at giving a brief account of how the activities of the Unit for isiXho-sa, one of the five units of the Stellenbosch University Language Centre, contributes to the devel-opment of integrated technical terminology lists for all departments of the University. After the reason for this terminology development has been ...

  6. Autonomy as the guiding aim of entrepreneurship education

    NARCIS (Netherlands)

    van Gelderen, M.W.

    2010-01-01

    Purpose: This paper has three purposes: first, to present a vision of entrepreneurship education that has the student's capacity for autonomous action as its ultimate aim; second, to convince the reader of the timeliness and relevance of such an approach; third, to outline how this can be

  7. Advanced Industrial Materials (AIM) Program: Annual progress report FY 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    In many ways, the Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven ``Vision Industries`` that use about 80% of industrial energy and generated about 90% of industrial wastes. The mission of AIM has, therefore, changed to ``Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.`` Though AIM remains essentially a National Laboratory Program, it is essential that each project have industrial partners, including suppliers to, and customers of, the seven industries. Now, well into FY 1996, the transition is nearly complete and the AIM Program remains reasonably healthy and productive, thanks to the superb investigators and Laboratory Program Managers. This Annual Report for FY 1995 contains the technical details of some very remarkable work by the best materials scientists and engineers in the world. Areas covered here are: advanced metals and composites; advanced ceramics and composites; polymers and biobased materials; and new materials and processes.

  8. A Question of Aims and Assumptions in Canadian Education.

    Science.gov (United States)

    MacIver, D. A.

    1979-01-01

    This article concurs with a critique in the OECD Report that Canadian education is organized along industrial lines and that this organization is for the purpose of achieving academic goals. Major criticism is aimed at the "over academization" of the schools and the influence of this on society. (Author/SJL)

  9. Autonomy as the Guiding Aim of Entrepreneurship Education

    Science.gov (United States)

    van Gelderen, Marco

    2010-01-01

    Purpose: This paper has three purposes: first, to present a vision of entrepreneurship education that has the student's capacity for autonomous action as its ultimate aim; second, to convince the reader of the timeliness and relevance of such an approach; third, to outline how this can be implemented. Design/methodology/approach: The paper…

  10. [Content analysis of food adverts aimed at children].

    Science.gov (United States)

    Ponce-Blandón, José Antonio; Pabón-Carrasco, Manuel; Lomas-Campos, María de Las Mercedes

    To determine the contents and persuasive techniques used in processed food adverts aimed at children in Andalusia, comparing them with those aimed at adults. Study based on advert content analysis with two phases: a descriptive design phase and an analytical observational design phase. A sample of adverts from 60hours of broadcasting from the two most watched television channels in Andalusia. A total of 416 food and non-alcoholic beverage adverts were obtained, for 91 different products. Approximately 42.9% (n=39) was aimed at children and 53.8% (n=49) were products classified as "unhealthy". Unhealthy foods were more common in adverts for children (p adverts for children. Food advertising aimed at children in Andalusia is mainly based on offering products with a low nutritional value and using persuasive resources based on fantasy or gifts. The message is focused on the incentive and not the food. More effective measures than the current self-regulatory systems must be put in place to counter these distorted adverts. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Anxiety and ironic effects in aiming at a far target

    NARCIS (Netherlands)

    Bakker, F.C.; Binsch, O.

    2011-01-01

    In far aiming the negative intention not to miss may ironically increase the tendency to do precisely that. Although cognitive constraints enhance the occurrence of ironic effects in the perceptual-motor domain the role of anxiety in inducing such effects has rarely been investigated while anxiety

  12. 'Omics' approaches in tomato aimed at identifying candidate genes ...

    African Journals Online (AJOL)

    adriana

    2013-12-04

    Dec 4, 2013 ... that provides a virtual workbench for researchers working ... lab, we undertook two different 'omics' approaches to in- .... In our laboratory, an association mapping approach by candidate gene has been undertaken with the aim of identifying among 96 different genotypes new alleles in genes that could.

  13. Ecological radiation monotoring in NPP region, aims and tasks

    International Nuclear Information System (INIS)

    Egorov, Yu.A.

    1986-01-01

    Aims and tasks of ecological radiation monitoring in the NPP region are discussed. The aims of monitoring are: to determine possible sequences of NPP radioactive release effects on ecosystems, taking place on the background of chemical and thermal pollution to develop standard of radiation effect on ecosystems; the aims includes also obtaining of information for forecasting and evaluating long-term radiation effects, establishment of factors characterizing the ecosystem state, establishment of a combined effect of radioactive wastes with chemical and thermal ones. Finally, the aim of monitoring consists in providing the natural object conservation in the NPP region under optimal operation conditions. Thus it is necessary to solve the following problems: to observe systematically release, transport and transformation, when transporting radioactive and chemical contaminants in terrestial and aquatic biocenoses, as well as injection and transport in them of waste heat; to observe systematically the natural physico-chemical, chemico-biological processes affecting the injection and transport of contaminants in ecosystem components; to observe systematically the natural and, probably, antropogenic processes; to carry out systematically observations of the ecosystem state in the NPP region and eco-systems-monitors

  14. Pursuing the Triple Aim: The First 7 Years.

    Science.gov (United States)

    Whittington, John W; Nolan, Kevin; Lewis, Ninon; Torres, Trissa

    2015-06-01

    POLICY POINTS: In 2008, researchers at the Institute for Healthcare Improvement (IHI) proposed the Triple Aim, strategic organizing principles for health care organizations and geographic communities that seek, simultaneously, to improve the individual experience of care and the health of populations and to reduce the per capita costs of care for populations. In 2010, the Triple Aim became part of the US national strategy for tackling health care issues, especially in the implementation of the Patient Protection and Affordable Care Act (ACA) of 2010. Since that time, IHI and others have worked together to determine how the implementation of the Triple Aim has progressed. Drawing on our 7 years of experience, we describe 3 major principles that guided the organizations and communities working on this endeavor: creating the right foundation for population management, managing services at scale for the population, and establishing a learning system to drive and sustain the work over time. In 2008, researchers at the Institute for Healthcare Improvement (IHI) described the Triple Aim as simultaneously "improving the individual experience of care; improving the health of populations; and reducing the per capita costs of care for populations." IHI and its close colleagues had determined that both individual and societal changes were needed. In 2007, IHI began recruiting organizations from around the world to participate in a collaborative to implement what became known as the Triple Aim. The 141 participating organizations included health care systems, hospitals, health care insurance companies, and others closely tied to health care. In addition, key groups outside the health care system were represented, such as public health agencies, social services groups, and community coalitions. This collaborative provided a structure for observational research. By noting the contrasts between the contexts and structures of those sites in the collaborative that progressed and

  15. Determination of aims military-technical policy of Ukraine

    Directory of Open Access Journals (Sweden)

    O. F. Salnikova

    2014-06-01

    Full Text Available In the article the aims of military-technical policy are considered. Determination of aims (tasks of military-technical policy, its maintenance, requirements to it and directions of its further development it must come true by the analysis of different factors of external and internal environment. Among such factors: geopolitical and military-political position of Ukraine and its military doctrine; realized and operating programs of development (reformation of the soldiery forming and them technical rigging; terms of future military operations and progress of their maintenance, forms, methods and characteristic signs of battle actions trend; substantive provisions of art of war; conceptions, theories and doctrines of battle application of the soldiery forming of the different states; resources dedicated by the state on development of military-technical sphere and others like that. The fundamental chart of sequence of forming of public military-technical policy is presented in the article.

  16. Research methodology the aims, practices and ethics of science

    CERN Document Server

    Pruzan, Peter

    2016-01-01

    This book is an in-depth guide to effective scientific research. Ranging from the philosophical to the practical, it explains at the outset what science can – and can’t – achieve, and discusses its relationship to mathematics and laws. The author then pays extensive attention to the scientific method, including experimental design, verification, uncertainty and statistics. A major aim of the book is to help young scientists reflect upon the deeper aims of their work and make the best use of their talents in contributing to progress. To this end, it also includes sections on planning research, on presenting one’s findings in writing, as well as on ethics and the responsibilities of scientists. .

  17. Learning object for teacher training aimed to develop communication skills

    Directory of Open Access Journals (Sweden)

    Norma Esmeralda RODRÍGUEZ RAMÍREZ

    2014-06-01

    Full Text Available This article presents the results and reflections obtained across a research aimed to analyze the quality criteria of an opened learning object oriented to develop communication skills in order to be able to report and validate it according to its content, pedagogic structure, technological structure, graphical and textual language and usability to teacher training, in order to base it theoretically, pedagogically and technologically. The research question was: Which are the quality criteria that a learning object aimed to develop communication skills must cover? Under a quantitative approach, there were electronic questionnaires applied to: 34 Technological University teachers, eight experts about of communicative competence, teaching, technology and graphic design. The results indicated that some of the quality criteria of learning object are: the effective managing of the learning content, the balanced composition of his pedagogic structure, the technological structure efficiency and the proper managing of graphical and textual language.

  18. Decent work: an aim for all made by all

    OpenAIRE

    Ferraro, Tânia; Pais, Leonor; dos Santos, Nuno R.

    2015-01-01

    The aim of this article is to analyse the 11 substantive elements of the Decent Work concept developed by the International Labour Organization. We identify 4 main aspects regarding the pursuit of decent work, which are challenges for the different agents who operate in society: (1) the responsibility shared among the various social agents; (2) cultural differentiation in expressing Decent Work; (3) its evolving character arising from the advancement of scientific knowledge; and finally, (4) ...

  19. Retrospective study of thyroid cancer treatment: aims and data

    International Nuclear Information System (INIS)

    Vosmikova, K.; Hermanska, J.; Jirsa, L.; Karny, M.; Samal, M.

    1998-01-01

    Although opinions preferring individual administration of activity in the treatment of thyroid cancer with 131 I predominate, sufficient quantitative arguments in favor of this approach are unavailable as yet. Therefore, a retrospective study involving statistical processing was proposed with the aim to evaluate the relations between available data of the patients and success of treatment. Ideally, recommendations regarding activity to be administered in dependence on the biophysical status of the patient should emerge from the study

  20. How students perceive teachers' activities aimed at stimulating critical thinking

    OpenAIRE

    Mirkov, Snežana; Gutvajn, Nikoleta

    2014-01-01

    Research in the field of education show that the application of modern methods and techniques of in-class learning enhance the development of critical thinking of students. We were interested in finding out the attitudes of students towards the stimulation of critical thinking, how students perceive the activities of teachers aimed at stimulating critical thinking and their relations. The questionnaire designed for a larger research on stimulating the inititative, cooperation and creativity d...

  1. Advanced Industrial Materials (AIM) program. Annual progress report. FY 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven `Vision Industries` that use about 80% of industrial energy and generated about 90% of industrial wastes. These are: aluminium; chemical; forest products; glass; metal casting; refineries; and steel. OIT is working with these industries, through appropriate organizations, to develop Visions of the desired condition of each industry some 20 or 25 years in the future and then to prepare Road Maps and Implementation Plans to enable them to reach their goals. The mission of AIM has, therefore, changed to `Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.` Though AIM remains essentially a National Laboratory Program, it is necessary that each project have industrial partners, including suppliers to, and customers of, the seven industries. Now, well into FY 1996, the transition is nearly complete and the AIM Program remains healthy and productive, thanks to the superb investigators and Laboratory Program Managers. Separate abstracts have been indexed into the energy database for articles from this report.

  2. Action Information Management System (AIMS): a User's View

    Science.gov (United States)

    Wiskerchen, M.

    1984-01-01

    The initial approach used in establishing a user-defined information system to fulfill the needs of users at NASA Headquarters was unsuccessful in bringing this pilot endeaveor to full project status. The persistence of several users and the full involvement of the Ames Research Center were the ingredients needed to make the AIMS project a success. The lesson learned from this effort is that NASA should always work from its organizational strengths as a Headquarters-Center partnership.

  3. Nanotechnology and nanomedicine: going small means aiming big.

    Science.gov (United States)

    Teli, Mahesh Kumar; Mutalik, Srinivas; Rajanikant, G K

    2010-06-01

    Nanotechnology is an emerging branch of science for designing tools and devices of size 1 to 100 nm with specific function at the cellular, atomic and molecular levels. The concept of employing nanotechnology in biomedical research and clinical practice is best known as nanomedicine. Nanomedicine is an upcoming field that could potentially make a major impact to human health. Nanomaterials are increasingly used in diagnostics, imaging and targeted drug delivery. Nanotechnology will assist the integration of diagnostics/imaging with therapeutics and facilitates the development of personalized medicine, i.e. prescription of specific medications best suited for an individual. This review provides an integrated overview of application of nanotechnology based molecular diagnostics and drug delivery in the development of nanomedicine and ultimately personalized medicine. Finally, we identify critical gaps in our knowledge of nanoparticle toxicity and how these gaps need to be evaluated to enable nanotechnology to transit safely from bench to bedside.

  4. Biomedical foundation supports technology aimed at destroying cancer cells

    OpenAIRE

    Nystrom, Lynn A.

    2008-01-01

    A new technology, using electric pulses to destroy cancer tissue and named by NASA Tech Briefs as one of seven key technological breakthroughs of 2007, is receiving additional support aimed at moving the procedure to the marketplace. One of its lead developers, Rafael V. Davalos, a faculty member of the Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences (SBES), received a $240,000 grant from the Wallace H. Coulter Foundation and $25,000 from the Wake Forest Com...

  5. NASA tells physicists to aim for the stars

    CERN Document Server

    MacIlwain, C

    1999-01-01

    Dan Goldin, administrator at NASA, suggested that the next generation of instruments for high-energy physics research should be built in space. This did not go down well at Fermilab where a case is being made for a new ground-based accelerator. Goldin's aim though was simply to tell the scientific community that NASA is prepared to spend big money on physics in space. NASA also wants to work more closely with the DOE and the NSF to support space-based experiments (1 page).

  6. Acid activation of natural clays aiming their application in adsorption

    International Nuclear Information System (INIS)

    Silva, M.M. da; Sousa, A.K.F. de; Lima, W.S.; Vasconcelos, P.N.M. de; Rodrigues, M. G.F.

    2012-01-01

    Clays of smectite type have wide application in industrial, mainly due to their adsorption properties. However, it is necessary to subject them to chemical treatments to optimize their potential. This study aimed to analyze the effects of acid activation on the clay Brasgel fresh. In the acid activation was used concentrated hydrochloric acid at different concentrations (3M, 4.5 M and 6 M) at a temperature of 70 ° C for 30 minutes. The samples fresh and activated technique were characterized by X-ray Diffraction (XRD). The results show that the properties of clay after activation are improved, it could be used as adsorbents in the treatment of wastewater. (author)

  7. No norm needed: on the aim of belief

    DEFF Research Database (Denmark)

    Steglich-Petersen, Asbjørn

    2006-01-01

    Does transparency in doxastic deliberation entail a constitutive norm of correctness governing belief, as Shah and Velleman argue? No, because this presupposes an implausibly strong relation between normative judgements and motivation from such judgements, ignores our interest in truth, and cannot...... explain why we pay different attention to how much justification we have for our beliefs in different contexts. An alternative account of transparency is available: transparency can be explained by the aim one necessarily adopts in deliberating about whether to believe that p. To show this, I reconsider...... the role of the concept of belief in doxastic deliberation, and I defuse 'the teleologian's dilemma'....

  8. Philosophy as Inquiry Aimed at the Absolute Knowledge

    Directory of Open Access Journals (Sweden)

    Ekaterina Snarskaya

    2017-09-01

    Full Text Available Philosophy as the absolute knowledge has been studied from two different but closely related approaches: historical and logical. The first approach exposes four main stages in the history of European metaphysics that marked out types of “philosophical absolutism”: the evolution of philosophy brought to light metaphysics of being, method, morals and logic. All of them are associated with the names of Aristotle, Bacon/Descartes, Kant and Hegel. Then these forms are considered in the second approach that defined them as subject-matter of philosophy as such. Due to their overall, comprehensive character, the focus of philosophy on them justifies its claim on absoluteness as far as philosophy is aimed at comprehension of the world’s unity regardless of the philosopher’s background, values and other preferences. And that is its prerogative since no other form of consciousness lays down this kind of aim. Thus, philosophy is defined as an everlasting attempt to succeed in conceiving the world in all its multifold manifestations. This article is to try to clarify the claim of philosophy on the absolute knowledge.

  9. Linking aims, paradigm and method in nursing research.

    Science.gov (United States)

    Houghton, Catherine; Hunter, Andrew; Meskell, Pauline

    2012-01-01

    To explore the use of paradigms as ontological and philosophical guides for conducting PhD research. A paradigm can help to bridge the aims of a study and the methods to achieve them. However, choosing a paradigm can be challenging for doctoral researchers: there can be ambiguity about which paradigm is suitable for a particular research question and there is a lack of guidance on how to shape the research process for a chosen paradigm. The authors discuss three paradigms used in PhD nursing research: post-positivism, interpretivism and pragmatism. They compare each paradigm in relation to its ontology, epistemology and methodology, and present three examples of PhD nursing research studies to illustrate how research can be conducted using these paradigms in the context of the research aims and methods. The commonalities and differences between the paradigms and their uses are highlighted. Creativity and flexibility are important when deciding on a paradigm. However, consistency and transparency are also needed to ensure the quality and rigour necessary for conducting nursing research. When choosing a suitable paradigm, the researcher should ensure that the ontology, epistemology and methodology of the paradigm are manifest in the methods and research strategies employed.

  10. Program for accident and incident management support, AIMS

    International Nuclear Information System (INIS)

    Putra, M.A.

    1993-12-01

    A prototype of an advisory computer program is presented which could be used in monitoring and analyzing an ongoing incident in a nuclear power plant. The advisory computer program, called the Accident and Incident Management Support (AIMS), focuses on processing a set of data that is to be transmitted from a nuclear power plant to a national or regional emergency center during an incident. The AIMS program will assess the reactor conditions by processing the measured plant parameters. The applied model of the power plant contains a level of complexity that is comparable with the simplified plant model that the power plant operator uses. A standardized decay heat function and a steam water property library is used in the integral balance equations for mass and energy. A simulation of the station blackout accident of the Borssele plant is used to test the program. The program predicts successively: (1) the time of dryout of the steam generators, (2) the time of saturation of the primary system, and (3) the onset of core uncovery. The coolant system with the actual water levels will be displayed on the screen. (orig./HP)

  11. Complementary coordination strategies in a joint Fitts’ reciprocal aiming task

    DEFF Research Database (Denmark)

    Konvalinka, Ivana; Skewes, Lea; Michael, J.

    How do dyads coordinate their actions to achieve a common goal when one person has the more difficult task? In the present study, dyads were instructed to engage in a Fitts’s reciprocal aiming task as accurately as possible, and at a given tempo sent through their headphones. They were in conditi......How do dyads coordinate their actions to achieve a common goal when one person has the more difficult task? In the present study, dyads were instructed to engage in a Fitts’s reciprocal aiming task as accurately as possible, and at a given tempo sent through their headphones. They were...... in conditions where they either received auditory feedback of 1) SELF-generated taps, 2) taps generated by the OTHER co-actor, or 3) regular, COMPUTER-generated taps. In conditions 2) and 3), they were also instructed to synchronize with their feedback as best as possible. In each trial, each participant...... a joint goal, by taking on leader-follower roles....

  12. Breaks in Play: Do They Achieve Intended Aims?

    Science.gov (United States)

    Blaszczynski, Alexander; Cowley, Elizabeth; Anthony, Christina; Hinsley, Kate

    2016-06-01

    Breaks in play represent a responsible gambling strategy designed to disrupt states of dissociation and enhance the likelihood of drawing attention to a player's session behaviour and expenditure with respect to time and money. The aim of the break in play is to motivate the player to modify or cease gambling so the activity remains within affordable levels. The aim of this study was to investigate whether imposed breaks in play in the absence of accompanying warning messages were effective in reducing cravings. Participants (141 university students) were randomly allocated to one of three conditions: 15 min computer simulated Black Jack play followed by no break, a 3 or 8 min break in play. Participants were administered a battery of measures to assess problem gambling card play, cravings, and dissociation to assess the effects of length of break on cravings. Results indicated that cravings increased rather than decreased with imposed breaks in play, and that the strength of cravings were higher following the eight- compared to 3-min break. It was concluded that breaks in play in isolation might produce counterproductive, unintended, and even perverse effects. The policy implications for responsible gambling strategies is that breaks in play ought to be accompanied with warning and/or personal appraisal messages if optimal effects in reducing within session gambling expenditure are to be achieved.

  13. Aims or purposes of school mediation in Spain

    Directory of Open Access Journals (Sweden)

    María-Isabel Viana-Orta

    2013-01-01

    Full Text Available Mediation continues to expand, both geographically and in terms of scope. Depending on its purpose, there are three main consolidated mediation models or schools worldwide: the Traditional-Linear Harvard model, which seeks to find an agreement between the parties; the Circular-Narrative model, which apart from the agreement also emphasizes communicational aspects; and the Transformational model, more focused on relational aspects between the parties than in the adoption of agreements. The aim of this study is to determine which is the goal or purpose of mediation, confining it to the school environment and to the Spanish context. A brief comparative study is presented to this end, in which the comparative units are all the Comunidades Autónomas [Autonomous Regions] that make up the Spanish territory (n = 17 and the variable compared is the aim or purpose of mediation in schools as established by all the regional rules on school life (n = 17 with the force of a decree.

  14. Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes

    International Nuclear Information System (INIS)

    Iwamura, Yoshihiro; Mori, Mayumi; Nakashima, Katsuhiko; Mikami, Toshiyuki; Murayama, Katsuhisa; Arai, Satoko; Miyazaki, Toru

    2012-01-01

    Highlights: ► AIM induces lipolysis in a distinct manner from that of hormone-dependent lipolysis. ► AIM ablates activity of peroxisome proliferator-activated receptor in adipocytes. ► AIM reduces mRNA levels of lipid-droplet coating proteins leading to lipolysis. -- Abstract: Under fasting conditions, triacylglycerol in adipose tissue undergoes lipolysis to supply fatty acids as energy substrates. Such lipolysis is regulated by hormones, which activate lipases via stimulation of specific signalling cascades. We previously showed that macrophage-derived soluble protein, AIM induces obesity-associated lipolysis, triggering chronic inflammation in fat tissue which causes insulin resistance. However, the mechanism of how AIM mediates lipolysis remains unknown. Here we show that AIM induces lipolysis in a manner distinct from that of hormone-dependent lipolysis, without activation or augmentation of lipases. In vivo and in vitro, AIM did not enhance phosphorylation of hormone-sensitive lipase (HSL) in adipocytes, a hallmark of hormone-dependent lipolysis activation. Similarly, adipose tissue from obese AIM-deficient and wild-type mice showed comparable HSL phosphorylation. Consistent with the suppressive effect of AIM on fatty acid synthase activity, the amount of saturated and unsaturated fatty acids was reduced in adipocytes treated with AIM. This response ablated transcriptional activity of peroxisome proliferator-activated receptor (PPARγ), leading to diminished gene expression of lipid-droplet coating proteins including fat-specific protein 27 (FSP27) and Perilipin, which are indispensable for triacylglycerol storage in adipocytes. Accordingly, the lipolytic effect of AIM was overcome by a PPARγ-agonist or forced expression of FSP27, while it was synergized by a PPARγ-antagonist. Overall, distinct modes of lipolysis appear to take place in different physiological situations; one is a supportive response against nutritional deprivation achieved by

  15. The article presents the analysis results of the production processes aimed at service production. The main features of service production are described and the terms of service production are formulated. It has been demonstrated, that airports can be considered as a service production enterprise. The specific features of the production peculiar to airports are noted. The production process at the airport is associated with the need to fulfill certain processes in real time, the presenceof random factors affecting the process (weather conditions, schedule changes, etc., special safety requirements, which lead to increase of the role of production informatization

    Directory of Open Access Journals (Sweden)

    2016-01-01

    Full Text Available The article presents the analysis results of the production processes aimed at service production. The main features of service production are described and the terms of service production are formulated. It has been demonstrated, that air- ports can be considered as a service production enterprise. The specific features of the production peculiar to airports are noted. The production process at the airport is associated with the need to fulfill certain processes in real time, the presenceof random factors affecting the process (weather conditions, schedule changes, etc., special safety requirements, which lead to increase of the role of production informatization.

  16. Microwave dielectric absorption spectroscopy aiming at novel dosimetry using DNAs

    Energy Technology Data Exchange (ETDEWEB)

    Izumi, Yoshinobu; Hirayama, Makoto; Matuo, Youichirou [Research Institute of Nuclear Engineering, University of Fukui, Fukui (Japan); Sunagawa, Takeyoshi [Fukui University of Technology, Fukui (Japan)

    2017-03-15

    We are developing L-band and S-band microwave dielectric absorption systems aiming novel dosimetry using DNAs, such as plasmid DNA and genomic DNA, and microwave technology. Each system is composed of a cavity resonator, analog signal generator, circulator, power meter, and oscilloscope. Since the cavity resonator is sensitive to temperature change, we have made great efforts to prevent the fluctuation of temperature. We have developed software for controlling and measurement. By using this system, we can measure the resonance frequency, f, and ΔQ (Q is a dimensionless parameter that describes how under-damped an oscillator or resonator is, and characterizes a resonator’s bandwidth relative to its center frequency) within about 3 minutes with high accuracy. This system will be expected to be applicable to DNAs evaluations and to novel dosimetric system.

  17. Tracking, aiming, and hitting the UAV with ordinary assault rifle

    Science.gov (United States)

    Racek, František; Baláž, Teodor; Krejčí, Jaroslav; Procházka, Stanislav; Macko, Martin

    2017-10-01

    The usage small-unmanned aerial vehicles (UAVs) is significantly increasing nowadays. They are being used as a carrier of military spy and reconnaissance devices (taking photos, live video streaming and so on), or as a carrier of potentially dangerous cargo (intended for destruction and killing). Both ways of utilizing the UAV cause the necessity to disable it. From the military point of view, to disable the UAV means to bring it down by a weapon of an ordinary soldier that is the assault rifle. This task can be challenging for the soldier because he needs visually detect and identify the target, track the target visually and aim on the target. The final success of the soldier's mission depends not only on the said visual tasks, but also on the properties of the weapon and ammunition. The paper deals with possible methods of prediction of probability of hitting the UAV targets.

  18. Advanced Industrial Materials (AIM) Program. Annual progress report, FY 1994

    Energy Technology Data Exchange (ETDEWEB)

    Sorrell, C.A.

    1995-05-01

    The Advanced Industrial Materials Program is a part of the Office of Industrial Technologies (OIT), Energy Efficiency and Renewable Energy in the Department of Energy. The mission of the AIM Program is to conduct applied research, development, and applications engineering work, in partnership with industry, to commercialize new or improved materials and materials processing methods that will improve energy efficiency, productivity, and competitiveness. AIM is responsible for identifying, supporting, and coordinating multidisciplinary projects to solve identified industrial needs and transferring the technology to the industrial sector. Program investigators in the DOE National Laboratories are working closely with approximately 100 companies, including 15 partners in Cooperative Research and Development Agreements. Work is being done in a wide variety of materials technologies, including intermetallic alloys, ceramic composites, metal composites, polymers, engineered porous materials, and surface modification. The Program supports other efforts in the Office of Industrial Technologies to assist the energy consuming process industries, including forest products, glass, steel, aluminum, foundries, chemicals, and refineries. To support OITs {open_quotes}Industries of the Future{close_quotes} initiatives and to improve the relevance of materials research, assessments of materials needs and opportunities in the process industries are being made. These assessments are being used for program planning and priority setting; support of work to satisfy those needs is being provided. Many new materials that have come into the marketplace in recent years, or that will be available for commercial use within a few more years, offer substantial benefits to society. This document contains 28 reports on advanced materials research. Individual reports have been processed separately for entry onto the Department of Energy databases.

  19. Aims of combined modality therapy in rectal cancer (M0).

    Science.gov (United States)

    Gerard, J P; Benezery, K; Doyen, J; Francois, E

    2014-01-01

    OPTIMIZING THE COST/BENEFIT RATIO OF TREATMENT: Evidence Based The aim of a cancer treatment is always to achieve the maximum of cure rate with a minimum of toxicity and best quality of life at an acceptable cost for the society. It is always a multifactorial challenge depending on the patient, the tumor, the doctor, and the society cultural and financial backgrounds. The goal is to find the best cost/benefit ratio between all possible strategies in agreement with a well-informed patient. In rectal cancer (M0) surgery is the cornerstone of treatment. Combined modality therapies aim at optimizing the cost/benefit ratio of possible strategies and only randomized trials can bring strong evidence regarding their results and recommendations. LESSONS FROM RANDOMIZED TRIALS: quite modest During the past decades many phase III trials have shown that: (1) neoadjuvant treatment even with "TME" surgery was better than adjuvant, (2) chemoradiotherapy (CRT) was better than RT alone, (3) long course CRT was probably more efficient (in terms of ypCR) than short course (25/5), and (4) capecitabine was as efficient as 5 FU but oxaliplatin was not adding benefit. Overall, the gains of nCRT remain modest and it is mainly a reduction in local relapse not exceeding 5 %, but no benefit in survival and neither in sphincter saving surgery has been proven. The way forwards organ preservation in case of CCR. Local control: can probably be improved for T4 tumors by RT dose escalation. Survival: can be increased by innovative medical treatment either before or after surgery. may be reduced by a less aggressive treatment in elderly. Conservative treatment: A new field of clinical research is to achieve "organ preservation" (and not only sphincter saving). To modify the surgical approach and preserve the whole rectum, neoadjuvant treatment must achieve safely a clinical complete response. As rectal adenocarcinoma is a relatively radioresistant tumor endocavitary irradiation (contact X-Ray) is a

  20. Poly(3-hexylthiophene): TIPS-pentacene blends aiming transistor applications

    Energy Technology Data Exchange (ETDEWEB)

    Silva Ozório, Maiza da, E-mail: ozoriounesp@gmail.com; Nogueira, Gabriel Leonardo; Morais, Rogério Miranda; Silva Martin, Cibely da; Constantino, Carlos José Leopoldo; Alves, Neri

    2016-06-01

    Poly(3-hexylthiophene):6,13-bis(triisopropylsilylethynyl)-pentacene (P3HT:TP) blends with a ratio of 1:1 (wt/wt) were deposited via spin coating on anodized oxide (Al{sub 2}O{sub 3}). A phase separation of the compounds was observed, resulting in the formation of crystalline aggregates of TP molecules that segregate vertically on the surface. The form of segregation depends on the oxide surface treatment used. Spectroscopy analysis shows a higher molecular order of P3HT in the blend than for neat film and that TP molecules are also distributed in the polymeric matrix. Regarding the OFET characteristics, charge carrier mobilities of 1.2 × 10{sup −3} cm{sup 2} V{sup −1} s{sup −1} and 2.0 × 10{sup −3} cm{sup 2} V{sup −1} s{sup −1} were obtained from devices for untreated and (hexamethyldisilazane) HMDS-treated Al{sub 2}O{sub 3} gate dielectric, respectively. These results confirm that P3HT:TP blends have good potential as an active layer in organic field effect transistors (OFETs). - Highlights: • Phase separation occurs in the P3HT:TP blend. • The P3HT:TP blends form aggregates that segregate vertically to the surface. • The molecular order of the P3HT is higher for the blend than for the neat film. • Treatment of surface with HMDS influence in the formation of the aggregate • The P3HT:TP blends have great viability of using for application in transistors.

  1. Fluency: an aim in teaching and a criterion in assessment

    Directory of Open Access Journals (Sweden)

    Aud Marit Simensen

    2010-05-01

    Full Text Available This article investigates the concept ‘fluency’ from different perspectives. When fluency is an aim in teaching, a thorough comprehension of the concept among teachers is a prerequisite for appropriate planning of instruction, including the choice of appropriate classroom activities. When fluency is an assessment criterion, it is even more important that examiners have a shared perception of the concept. The present article starts by presenting common perceptions of the concept and goes on to explore some of the current research. Next, it provides a historical overview of the place of fluency in teaching theory and explains some of the preconditions for the inclusion of this concept among teaching objectives and assessment criteria. It will also, as an illustration, give an outline of the position of the concept over time in the Norwegian school system on the basis of an analysis of the relevant syllabuses. Finally, the article explicates the notion of language use as a complex cognitive skill and explores current method¬ological ideas about teaching towards fluency.

  2. A proper methodology aimed at surface wave tomography

    Directory of Open Access Journals (Sweden)

    J. Badal

    1997-06-01

    Full Text Available When applying a methodology for obtaining the 3D shear-wave velocity structure of a medium from surface wave dispersion data, the problem must be considered with caution since one inverts path-averaged velocities and the use of any inversion method entails some drawbacks such as lack of uniqueness, unwarranted stability and constraints affecting the data. In order to avoid the application of consecutive inversions and to overcome these drawbacks, we propose alternative mapping methods, for example spatial prediction methods, or else the use of an algorithm that, from a mathematical viewpoint, can be understood through the application of the orthogonal projection theorem onto convex sets (POCS. Among the first ones, we try inverse weighted distance interpolation. The POCS algorithm we have used discretises a second order differential equation for the velocity field with boundary conditions. All these imaging techniques aimed at volumetric modelling and the visualisation of data are discussed, and finally we show some results based on ray path velocities obtained previously by inversion of phase and group velocities of Rayleigh waves propagating across the Iberian peninsula.

  3. Ecolabel and ecodesign. Aims impossible for small and medium companies?

    International Nuclear Information System (INIS)

    Luciani, R.; Andriola, L.; Masoni, P.

    2000-01-01

    It is commonly held by now that a policy of sustainable development in the production sector cannot be faced in terms of simply reducing the environmental impact at the end of the production chain but should be imprinted with a preventive approach which, intervening on the production cycles and the products themselves, helps minimize pressure on the environment. To be competitive manufacturing industry must contribute a determinant amount to sustainable development by reducing the material content of products and increasing their use value, through processes and products-services that are innovative, safer, cleaner and based on a low use of natural resources. To be effective and avoid merely shifting the problem, this work should not be aimed at the level of individual plants or industries but be broadly planned, taking into account the entire value chain and hence the product's whole life-cycle. In addition, support should be given to small and medium-sized companies that characterize Italian production, because they find it hard to use the tools of a product policy originally ideated for big business [it

  4. Education and religion in advertising aimed at children

    Directory of Open Access Journals (Sweden)

    Edson Ponick

    2015-10-01

    Full Text Available This article presents a theoretical and analytical reflection on the issue of education and religion in advertising aimed at children. It describes distinctive features of postmodernity – immediacy, consumerism and secularization – as constitutive elements of our time and characterizes media as a sort of all-powerful being that channels, processes, produces and disseminates these postmodern attributes, while offering products that form and shape the way of life of Western society. The article goes on to analyze the content of two advertisements, identifying in them the possible presence of an educational religious-theological discourse. It contends that there is an intrinsic relation between education and religion in advertising, one which strongly influences the learning, thinking and acting patterns of children through such practices as gaining power by what they consume and seeing consumption as a means to attain a more prominent position in this world. In advertising, forms of socialization are presented to children. Finally, it is suggested that one way to introduce and discuss advertisements in educational contexts is by reading and analyzing the narratives of advertising together with the children.

  5. Chemistry Journal Articles: An Interdisciplinary Approach to Move Analysis with Pedagogical Aims

    Science.gov (United States)

    Stoller, Fredricka L.; Robinson, Marin S.

    2013-01-01

    This article highlights aspects of an interdisciplinary (chemistry-applied linguistics) English for Specific Purposes (ESP) course- and materials-development project. The project was aimed at raising genre awareness among chemistry students and faculty, in addition to improving students' disciplinary reading and writing. As part of the project,…

  6. Packaged water-injection plant aimed at offshore use

    Energy Technology Data Exchange (ETDEWEB)

    1977-05-02

    A packaged, fully instrumented water treatment and injection system for offshore use has been designed by the Aker Group of Oslo, Norway. The design also could be used on shore. Its standard Akar WIP 50 plant is rated at 50,000-bpd capacity at 3,000 psi injection pressure. Units may be arranged to achieve may treatment and injection capability. Systems use treated seawater, produced water, fresh water or ground water. Water supply is chlorinated and coarse-filtered at the system intake. Water carried through plastic, Eternit, or epoxy coated pipe will not need further treatment (deaeration for example) at the intake, Aker points out. Water injected into producing formations meets well-defined specifications. Before injection, water is filtered to reduce contaminants to an acceptable level. The standard degree of filtration is finer than 10 mu which helps to avoid blocking wells. Filters are simple in design and efficient in operation. Dependability and maintenance ease are design considerations. Filters have small external dimensions, are lightweight, and provide guaranteed degrees of filtration. A self-cleaning filter (50 mu size) can be put ahead of the fine filter to remove larger particles. Vacuum stripping is seen as the oxygen-removal method for the WIP 50.

  7. European Commission action aimed at constructing a European regulatory framework

    International Nuclear Information System (INIS)

    Ristori, D.

    2010-01-01

    The challenge of a low-carbon economy provides a new incentive for the development of renewable energies as well as of nuclear energy. The latter calls for a high level of safety and security. The EU has a role in providing a legal framework for this purpose as well as ensuring that these standards are respected internationally. For over 50 years the EURATOM Treaty has offered the legal basis for a wide range of initiatives supporting this policy. The EU has competences under chapter 3, 'Health and Safety', for the establishment of basic safety standards for the protection against ionizing radiation. These have extended beyond the scope of nuclear energy and now include medical exposures as well as natural radiation sources. The latest revision of the BSS-Directive, to be proposed in 2011, was an opportunity for the consolidation of all Community legislation. A ruling of the Court of Justice in 1999 paved the way for the establishment of standards on the safety of nuclear installations. A common vision on this matter was achieved through the creation of a body of European Safety Regulators (ENSREG) and the adoption of a specific Safety Directive in 2009. This new Directive translates internationally agreed safety standards into legally binding EU legislation and strengthens the position of national Regulators. (author)

  8. Integrated planning aimed at sustainability city logistics solutions

    Directory of Open Access Journals (Sweden)

    Tadić Snežana R.

    2015-01-01

    Full Text Available The main objective of city logistics system is sustainability, or efficiency, wide acceptability, environmental protection and safety. On the other hand, the city logistics system is very complex. It is characterized by a large number of participants, with different, usually conflicting goals and complex interactions. In addition, the system of city logistics is part of a wider system of the town, the region, and there are complex interactions with the external environment. The system depends on the specific characteristics of the city, affects other forms of urban mobility and is subject to the policies of higher rank (regional, national policy. Given the exceptional complexity, sustainable city logistics solution requires an integrated approach in all phases of planning, from stages of problem identification, definition of alternative solutions and effects assessment, to implementation and by exploitation. In this way, the solution of city logistics is becoming widely accepted and not only affects the efficiency of the socio-economic system of town, already on the sustainability of the whole region.

  9. SaudiVeg ecoinformatics: Aims, current status and perspectives

    Directory of Open Access Journals (Sweden)

    Mohamed A. El-Sheikh

    2017-02-01

    Full Text Available During the last decade many electronic databases of vegetation plots were established in many countries around the world. These databases contain valuable phytosociological information assisting both governmental and NGO (Non-governmental organizations agencies to formulate strategies and on-ground plans to manage and protect nature resources. This paper provides an account on aims, current status and perspectives of building of a vegetation database for the Central Region (Najd of Saudi Arabia – the founding element of the Saudi Vegetation Database (SVD. The data stored by the database are sample plots (vegetation relevés collected according to the field techniques of the Braun-Blanquet approach (lists of taxa accompanied by semi-quantitative cover assessment, and are accompanied by general vegetation characteristics such as vegetation layering and cover, information on life-form of the recorded species, geographical coordinates, altitude, soil typology, topography and many more. More than 2900 vegetation-plot records (relevés have so far been collected in the Najd region; of these more than 2000 have already been stored using the Turboveg database platform. These field records cover many habitats such as depressions, wadis (dry river beds, agricultural lands, sand dunes, sabkhas, and ruderal habitats. The ecological information collected in the database is currently the largest set of vegetation data collated into a database in the Middle East. These data are of great importance for biodiversity studies in Saudi Arabia, since the region is recording a loss of biodiversity at a fast rate due to environmental problems such as global warming and land-use changes. We envisage that this database would catalyze further data collection on vegetation of the entire Arabian Peninsula, and shall serve as one of the most important datasets for classification and mapping of the vegetation of the Kingdom of Saudi Arabia.

  10. Ready! Aim! Fire! targeting the right medical science journal.

    Science.gov (United States)

    Hardman, Timothy C; Serginson, James M

    2017-09-01

    Inadvertently submitting a paper to a journal that is unlikely to publish it is a waste of resources and ultimately delays dissemination of one's research. A high proportion of manuscripts are rejected by their author's first-choice journal. The aim of the present work was to review guidance provided within the literature for journal selection that might minimize the chance of manuscript rejection. We also consider papers that encompass more than one main medical science and describe the selection process that we used with a paper that was published in Cardiovascular Endocrinology . A database search (Embase, PubMed and Medworm) was performed for all articles published in the scientific literature providing guidance on journal selection. Articles were identified that either had journal selection as their principal topic or included journal selection as part of a broader discussion of publishing. The relative performance of four free-to-use, web-based applications that claim to provide guidance on journal selection was compared. The searches identified 286 hits, of which 249 were in English. Of these papers, 16 discussed journal selection and a further 10 articles were identified from citations within the original 16 articles. Only one article described a comprehensive model for submission decision-making. Identification of appropriate candidate journals by various web-based applications was erratic, with the Jane database providing the most robust suggestions. Our work suggests that little attention has been focused in the scientific literature on the mechanisms that authors use to select a journal for their work. Nevertheless, scientists for the most part seem to have a good sense of where their papers are most likely to be accepted. Beyond ensuring that a manuscript fulfils all the target journal's requirements, the literature suggests that it is important to have an objective view of the scientific contribution or 'value' of your work.

  11. Construction of a narrative network aimed at implementing inclusive processes

    Directory of Open Access Journals (Sweden)

    Francesca Salis

    2017-01-01

    Full Text Available The concept of inclusion in its complex aspects aimed at overcoming barriers to learning and involvement has led this research in university, in the light of special pedagogy and didactics, on the basis of inclusion index parameters, detecting the levels of integrated planning with the territory. The purpose of this study is not limited to disability and to special education needs but goes further than that encompassing isolation and/or exclusions. As far as the university system is concerned, it becomes significant to enquire about the inclusion process, in this case by means of a narrative approach, bearing in mind that organizational and learning models, together with access modes may give rise to social exclusion.Università e territorio: costruzione di una rete narrativa per l’implementazione dei processi inclusiviIl costrutto di inclusione nelle sue complesse sfaccettature mirate al superamento delle barriere all’apprendimento e alla partecipazione, ha guidato il presente lavoro di ricerca in ambito universitario alla luce della pedagogia e didattica speciale, sulla base dei parametri dell’Index for Inclusion, rilevando i livelli di progettazione integrata con il territorio. Il suo raggio di azione non si limita alla disabilità ma abbraccia tutti i bisogni educativi speciali, e l’isolamento, la marginalizzazione e/o le esclusioni che ne derivano. Rispetto al sistema universitario è rilevante interrogarsi sul processo di inclusione, in questo caso sulla base dell’approccio narrativo, preso atto che il modello organizzativo e le modalità di accesso e formative possono essere causa di esclusione formativa e sociale.

  12. Bioeconomy in Romania - Aim for an Innovative Economy?

    Directory of Open Access Journals (Sweden)

    Manuela Dora Orboi

    2017-11-01

    Full Text Available In the world, population growth phenomenon is accentuated, being estimated an increase of 30% over the next 40 years, leading to more than 9 billion people by the year 2050. In this period, mankind will face a exploitation without preceding of its natural resources, them being finite. There will be significant climate change, loss of biodiversity, increasing pressures on the environment, threatening, thus, the stability of living systems. In this context, Europe needs to change the manner of approaching to production, consumption, processing, storage, recycling and disposal of biological resources. Bioeconomy is the key element for smart growth in Europe, aspect pointed out in the Europe 2020 strategy adopted by the European Commission. This strategy is based on the Seventh Framework Program for Research and Technological Development (FP7 and the EU Framework Program for Research and Innovation (Horizon 2020. Bio-economy represents a cost savings in using the soil and sea biological resources, including the production of renewable biological resources and conversion of those resources and waste to value-added products (food, feed, bio bioenergy. Bioeconomy include sectors like agriculture, forestry, fisheries, food industry, as well as parts of chemical industry biotechnological and energetic. Bioeconomy relies on life sciences, agronomy, ecology, food science, social sciences, biotechnology, information and communication technologies and engineering. The bioeconomy support granted in the European Union offers many opportunities for Romania. Through bioeconomy specific approaches, the bioresources production potential in Romania could be exploited. Developing and implementing new solutions for better exploitation of this Romanian potential requires a significant investment in education and research. For Romania, the bioeconomy is a chance, an objective for a more innovative economy, smart, low emissions and with more sustainable use of renewable

  13. Aiming for a fully integrated computerized procedure system

    International Nuclear Information System (INIS)

    Marron, J. E.

    2006-01-01

    A fully integrated Computerized Procedure System must provide, at a minimum, a) Specification: access to design basis procedures, b) Monitoring: incorporation of real-time plant status, c) Advise: highlighting likely decision paths, and d) Reporting: logging conditions and actions taken. The CPS plays a critical role in overcoming the human factors that lead to accidents. At the same time it can be an essential tool in providing the information and automation to augment what humans do best, identify patterns and make associative leaps in the presence of ambiguous data. Timeliner and TaskGuide are examples of CPS that have evolved from projects in the aerospace industry. They illustrate certain common characteristics of a CPS, namely the knowledge base, user interface, and traceability features. The complexity and number of procedures for a current nuclear project has led to the development of two tools, the Power Generation Control System (PGCS) and the Online Procedure System (OLPS). Together, these systems address the knowledge-base and user interface aspects of a CPS and go a long way in addressing other areas. PGCS and OLPS contain full configuration management capabilities for procedures and the operating recipe. They include administrative functions for online and offline management of documents and data. Some lessons learned from this pair of programs developed by Invensys is the need for more integrated recording mechanisms. The future of CPS is likely to see higher integration of the document access, system status, decision support and logging capabilities. The CPS may evolve into the standard operational interface. Internet technologies that are common-place today have made the possibility of the Active Document a reality. The OPC Foundation is pursuing standards that may accelerate such developments. (authors)

  14. Aiming at Targets: The Autobiography of Robert C. Seamans, Jr.

    Science.gov (United States)

    Seamans, Robert C., Jr.

    1996-01-01

    Bob Seamans originally was inspired to write this book for his family and friends. That is a large audience. By his own count his immediate family numbers twenty-four, not counting brothers and cousins and their families. His friends are uncounted but surely run to hundreds. As one of them and as a colleague at NASA, I am pleased and honored that he asked me to write this foreword. While written in Bob's unique and informal style, this autobiography has significance for many readers beyond his large circles of family and friends. Leaders and students of large, complex technological endeavors should be able to learn much from reading how Bob faced the daunting technical and management challenges in his career. As the title of this book implies, Bob has always set high goals for himself and then kept his eyes focused on both the necessary details and the broader picture. His ability to shift smoothly among jobs that required seemingly disparate abilities and skills speaks volumes about his insight, dedication, and enthusiasm for achievement. The book spans a truly remarkable life story. Bob first takes us through his growing up, education, and early professional and family life. Next he focuses on the crucial years when he was the general manager of NASA. Then he moves on to his career in the top jobs at the Air Force, the National Academy of Engineering, and the Energy Research and Development Administration. Finally, he touches on his later leadership activities in the academic and business worlds. Aiming at Targets is a series of fascinating topical vignettes covering his professional life. Taken together, like broad brushstrokes in an impressionist painting, they give a better picture of Bob Seamans and his work than a detailed recitation of facts and dates could hope to do. This is a cheerful account of an interesting and successful career. The book is full of good stories, with many memorable characters. Like the proverbial sundial, it counts the sunny hours

  15. Straight sinus: ultrastructural analysis aimed at surgical tumor resection.

    Science.gov (United States)

    Amato, Marcelo Campos Moraes; Tirapelli, Luis Fernando; Carlotti, Carlos Gilberto; Colli, Benedicto Oscar

    2016-08-01

    OBJECTIVE Accurate knowledge of the anatomy of the straight sinus (SS) is relevant for surgical purposes. During one surgical procedure involving the removal of part of the SS wall, the authors observed that the venous blood flow was maintained in the SS, possibly through a vein-like structure within the dural sinus or dural multiple layers. This observation and its divergence from descriptions of the histological features of the SS walls motivated the present study. The authors aimed to investigate whether it is possible to dissect the SS walls while keeping the lumen intact, and to describe the histological and ultrastructural composition of the SS wall. METHODS A total of 22 cadaveric specimens were used. The SS was divided into three portions: anterior, middle, and posterior. The characteristics of the SS walls were analyzed, and the feasibility of dissecting them while keeping the SS lumen intact was assessed. The thickness and the number of collagen fibers and other tissues in the SS walls were compared with the same variables in other venous sinuses. Masson's trichrome and Verhoeff's stains were used to assess collagen and elastic fibers, respectively. The data were analyzed using Zeiss image analysis software (KS400). RESULTS A vein-like structure independent of the SS walls was found in at least one of the portions of the SS in 8 of 22 samples (36.36%). The inferior wall could be delaminated in at least one portion in 21 of 22 samples (95.45%), whereas the lateral walls could seldom be delaminated. The inferior wall of the SS was thicker (p < 0.05) and exhibited less collagen and greater amounts of other tissues-including elastic fibers, connective tissue, blood vessels, and nerve fibers (p < 0.05)-compared with the lateral walls. Transmission electron microscopy revealed the presence of muscle fibers at a level deeper than that of the subendothelial connective tissue in the inferior wall of the SS, extending from its junction with the great cerebral vein

  16. Nisin Production Utilizing Skimmed Milk Aiming to Reduce Process Cost

    Science.gov (United States)

    Jozala, Angela Faustino; de Andrade, Maura Sayuri; de Arauz, Luciana Juncioni; Pessoa, Adalberto; Penna, Thereza Christina Vessoni

    Nisin is a natural additive for conservation of food, pharmaceutical, and dental products and can be used as a therapeutic agent. Nisin inhibits the outgrowth of spores, the growth of a variety of Gram-positive and Gram-negative bacteria. This study was performed to optimize large-scale nisin production in skimmed milk and subproducts aiming at low-costs process and stimulating its utilization. Lactococcus lactis American Type Culture Collection (ATCC) 11454 was developed in a rotary shaker (30°C/36 h/100 rpm) in diluted skimmed milk and nisin activity, growth parameters, and media components were also studied. Nisin activity in growth media was expressed in arbitrary units (AU/mL) and converted to standard nisin concentration (Nisaplin®, 25 mg of pure nisin is 1.0×106 AU/mL). Nisin activity in skimmed milk 2.27 gtotal solids was up to threefold higher than transfers in skimmed milk 4.54 gtotal solids and was up to 85-fold higher than transfers in skimmed milk 1.14 gtotal solids. L. lactis was assayed in a New Brunswick fermentor with 1.5 L of diluted skimmed milk (2.27 gtotal solids) and airflow of 1.5 mL/min (30°C/36/200 rpm), without pH control. In this condition nisin activity was observed after 4 h (45.07 AU/mL) and in the end of 36 h process (3312.07 AU/mL). This work shows the utilization of a low-cost growth medium (diluted skimmed milk) to nisin production with wide applications. Furthermore, milk subproducts (milk whey) can be exploited in nisin production, because in Brazil 50% of milk whey is disposed with no treatment in rivers and because of high organic matter concentrations it is considered an important pollutant. In this particular case an optimized production of an antimicrobial would be lined up with industrial disposal recycling.

  17. SOFTWARE TOOLS FOR COMPUTING EXPERIMENT AIMED AT MULTIVARIATE ANALYSIS IMPLEMENTATION

    Directory of Open Access Journals (Sweden)

    A. V. Tyurin

    2015-09-01

    Full Text Available A concept for organization and planning of computational experiment aimed at implementation of multivariate analysis of complex multifactor models is proposed. It is based on the generation of calculations tree. The logical and structural schemes of the tree are given and software tools, as well, for the automation of work with it: calculation generation, carrying out calculations and analysis of the obtained results. Computer modeling systems and such special-purpose systems as RACS and PRADIS do not solve the problems connected with effective carrying out of computational experiment, consisting of its organization, planning, execution and analysis of the results. Calculation data storage for computational experiment organization is proposed in the form of input and output data tree. Each tree node has a reference to the calculation of model step performed earlier. The storage of calculations tree is realized in a specially organized directory structure. A software tool is proposed for creating and modifying design scheme that stores the structure of one branch of the calculation tree with the view of effective planning of multivariate calculations. A set of special-purpose software tools gives the possibility for the quick generation and modification of the tree, addition of calculations with step-by-step change in the model factors. To perform calculations, software environment in the form of a graphical user interface for creating and modifying calculation script has been developed. This environment makes it possible to traverse calculation tree in a certain order and to perform serial and parallel initiation of computational modules. To analyze the results, software tool has been developed, operating on the base of the tag tree. It is a special tree that stores input and output data of the calculations in the set of changes form of appropriate model factors. The tool enables to select the factors and responses of the model at various steps

  18. Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes

    Energy Technology Data Exchange (ETDEWEB)

    Iwamura, Yoshihiro; Mori, Mayumi; Nakashima, Katsuhiko [Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Mikami, Toshiyuki; Murayama, Katsuhisa [Genomic Science Laboratories, Dainippon Sumitomo Pharma Co. Ltd., 3-1-98 Kasugadenaka, Konohana-ku, Osaka 554-0022 (Japan); Arai, Satoko [Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Miyazaki, Toru, E-mail: tm@m.u-tokyo.ac.jp [Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)

    2012-06-08

    Highlights: Black-Right-Pointing-Pointer AIM induces lipolysis in a distinct manner from that of hormone-dependent lipolysis. Black-Right-Pointing-Pointer AIM ablates activity of peroxisome proliferator-activated receptor in adipocytes. Black-Right-Pointing-Pointer AIM reduces mRNA levels of lipid-droplet coating proteins leading to lipolysis. -- Abstract: Under fasting conditions, triacylglycerol in adipose tissue undergoes lipolysis to supply fatty acids as energy substrates. Such lipolysis is regulated by hormones, which activate lipases via stimulation of specific signalling cascades. We previously showed that macrophage-derived soluble protein, AIM induces obesity-associated lipolysis, triggering chronic inflammation in fat tissue which causes insulin resistance. However, the mechanism of how AIM mediates lipolysis remains unknown. Here we show that AIM induces lipolysis in a manner distinct from that of hormone-dependent lipolysis, without activation or augmentation of lipases. In vivo and in vitro, AIM did not enhance phosphorylation of hormone-sensitive lipase (HSL) in adipocytes, a hallmark of hormone-dependent lipolysis activation. Similarly, adipose tissue from obese AIM-deficient and wild-type mice showed comparable HSL phosphorylation. Consistent with the suppressive effect of AIM on fatty acid synthase activity, the amount of saturated and unsaturated fatty acids was reduced in adipocytes treated with AIM. This response ablated transcriptional activity of peroxisome proliferator-activated receptor (PPAR{gamma}), leading to diminished gene expression of lipid-droplet coating proteins including fat-specific protein 27 (FSP27) and Perilipin, which are indispensable for triacylglycerol storage in adipocytes. Accordingly, the lipolytic effect of AIM was overcome by a PPAR{gamma}-agonist or forced expression of FSP27, while it was synergized by a PPAR{gamma}-antagonist. Overall, distinct modes of lipolysis appear to take place in different physiological

  19. [A workplace intervention aimed at increasing awareness in nursing personnel performing manual handling activities].

    Science.gov (United States)

    Scorpiniti, A; Lorusso, A; L'Abbate, N

    2007-01-01

    Here we describe a workplace intervention aimed at reducing the risk of low back pain in nursing personnel. The intervention we carried out included a specific ergonomic training and an exercise program according to the Feldenkrais Method. After the intervention, we evaluated its effect on the execution of manual handling activities in nurses. We found an increased rate of correct manual handling in the post-intervention period.

  20. Definition, aims, and implementation of GA(2) LEN Urticaria Centers of Reference and Excellence

    DEFF Research Database (Denmark)

    Maurer, M; Metz, M; Bindslev-Jensen, C

    2016-01-01

    BACKGROUND: GA²LEN, the Global Allergy and Asthma European Network, has recently launched a program for the development, interaction, and accreditation of centers of reference and excellence in special areas of allergy embedded in its overall quality management of allergy centers of excellence...... such as urticaria. AIMS: Here, we describe the aims, the requirements and deliverables, the application process, and the audit and accreditation protocol for GA²LEN UCAREs. RESULTS: The main aims of GA²LEN UCAREs are to provide excellence in urticaria management, to increase the knowledge of urticaria by research...... and education, and to promote the awareness of urticaria by advocacy activities. To become a certified GA²LEN UCARE, urticaria centers have to apply and fulfill 32 requirements, defined by specific deliverables that are assessed during an audit visit. DISCUSSION AND CONCLUSION: The GA²LEN UCARE program...

  1. EE-3A Logging Report

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, David W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    1993-12-15

    Two logs of EE-3A were performed during the last couple of weeks. The first of which, was a Temperature/Casing-Collar Locator (CCL) log, which took place on Friday, December 10th., 1993. The second log was a Caliper log which was done in cooperation with the Dia-Log Company, of Odessa, TX. on Monday, December, 13th., 1993.

  2. Differential identification of aims and results of formation plans: an application to the Spanish aquaculture

    Directory of Open Access Journals (Sweden)

    María Monserrat Cruz González

    2011-06-01

    Full Text Available The main aims of the formation, related theoretically to the performance of human resources, self-training, information and effectiveness, have been identified as the amount in which the company goes further from knowledge to learning. In this paper three hypotheses applied to the Spanish aquaculture are proposed to model the differential aim follow-up and the achievements of the formation plans. The empirical analysis has been carried out with the data of 99 representative companies of the aquaculture sector. The SPSS 19 statistical program was used for the data analysis. A factor analysis was made by the method of principal components. Eighteen nonparametric tests of Kruskal-Wallis type were applied, as well as 36 chi-squared tests. As a result, three principal components were identified that explain 80% of the variance of the aims: the first one refers to policies of implication of human resources, the second one is relatedto objective circumstances and the third one is associated to dynamism. It was confirmed that the relevance of aims is proportional to the percentage of expense in formation and, specifically, it is greater in suppliers. Finally, significantdifferences in the results of the formation with respect to the reduction of errors were observed, this reduction being greater in fish distribution and production. Significant differences were also observed in the effect of the formation on the motivation of the employee, this being greater in fish suppliers and producers

  3. Ecosystem-Based Adaptation for Food Security in the AIMS SIDS: Integrating External and Local Knowledge

    Directory of Open Access Journals (Sweden)

    Jessica Mercer

    2014-08-01

    Full Text Available This paper critically reviews ecosystem-based adaptation (EbA approaches for food security under climate change, specifically for the Small Island Developing States (SIDS comprising the Africa, Indian Ocean, Mediterranean and South China Sea (AIMS region. The focus is on integrating different knowledge forms. An analysis of current EbA approaches for food security is undertaken, alongside a review of methodologies for integrating local and external knowledge. Key gaps and actions for EbA for food security in the AIMS region, and potentially further afield, are identified. The gaps indicate the lack of coherence in AIMS SIDS approaching food security, in terms of policies and actions not reflecting the ecosystem-food-climate nexus, the lack of a regional framework despite similarities amongst the SIDS, and the infrequency with which knowledge integration occurs. To fill these gaps, suggested actions highlight knowledge identification and combination, learning from others and from history, using local champions, and regularly monitoring and evaluating progress. These actions will push forward the EbA agenda through improved development and use of knowledge, better connections amongst the AIMS SIDS and farther afield, and more local-national-regional collaboration.

  4. Specific phobia.

    Science.gov (United States)

    Silverman, Wendy K; Moreno, Jacqueline

    2005-10-01

    This article describes specific phobia of childhood and its clinical presentation, discusses issues related to the differential diagnosis of specific phobia, considers the issue of comorbidity among phobic and anxiety disorders and developmental trends in the manifestation of fears, summarizes the epidemiology, causes, and course of specific phobia, and presents assessment and treatment issues. Finally, a case study is offered that serves to illuminate the major topics outlined in the article.

  5. Adequate procedures for specific exams

    International Nuclear Information System (INIS)

    Staevie, G.L.G.; Gattringer, D.K.; Dal Mas, C.R.; Tessman, M.

    1996-01-01

    Some ideal procedures for specific radiographic exams are briefly presented. The aim is to improve the quality standard, establishing a specific method for each exam in order to decrease films waste and reduce the patient dose exposure

  6. Interventions aimed at increasing knowledge and improving attitudes towards people with intellectual disabilities among lay people.

    Science.gov (United States)

    Seewooruttun, Leila; Scior, Katrina

    2014-12-01

    Despite policies aimed at ensuring equal rights and maximising respect and social inclusion for people with intellectual disabilities, in their daily lives many continue to face negative attitudes and discrimination within society. Misconceptions about what it means to have an intellectual disability and about the capabilities of people with intellectual disabilities appear widespread, and may contribute to prejudice and discrimination. This review provides a summary and evaluation of empirical interventions aimed at increasing knowledge and targeting negative attitudes towards this population among lay people of working age. An electronic search using PsycINFO, Web of Science and PubMed identified 22 English language studies published between 1990 and early 2014 that reported a specific intervention with a lay population sample. The majority of studies reported promising outcomes, particularly those aimed at increasing knowledge of intellectual disability through education. Support for the positive influence of contact with people with intellectual disabilities was demonstrated across several interventions. Interventions delivered at least partly by individuals with intellectual disabilities, and educational interventions appear to hold the most promise. The evidence is limited though by the weaknesses of measurement tools employed. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  7. Effectiveness of an exercise program aimed at pregnant institutionalized by premature rupture of membranes (PROM.

    Directory of Open Access Journals (Sweden)

    Enrique Ramón Arbués

    2013-03-01

    Full Text Available In certain circumstances such as premature rupture of membranes (PROM or preterm labor is usually recommended hospital bed rest. But if this is prolonged, may result from negative consequences both physically and emotionally. The aim of this study was to determine the effects of a specific exercise program on physical self-concept and levels of anxiety and depression in a group of pregnant women diagnosed with uncomplicated PROM. A clinical trial was performed on a sample of 50 women diagnosed with uncomplicated RPM at week 32-33 of gestation. In the intervention group performed aerobic exercise routine specifically designed for later (week 34 of gestation to compare their levels of physical self and emotional discomfort (anxiety and depression with a control group with similar characteristics. Results of this investigation show that, in pregnant women uncomplicated diagnostic PROM, a specific exercise program improves physical self-concept and levels of anxiety and depression (p <0.05. Despite recommended further research in this field, does not seem justified the conservative management of complete rest is usually performed in these patients.

  8. Probe specificity

    International Nuclear Information System (INIS)

    Laget, J.M.

    1986-11-01

    Specificity and complementarity of hadron and electron probes must be systematically developed to answer three questions currently asked in intermediate energy nuclear physics: what is nucleus structure at short distances, what is nature of short range correlations, what is three body force nature [fr

  9. Interventions aimed at closing the social class achievement gap: changing individuals, structures, and construals.

    Science.gov (United States)

    Dittmann, Andrea G; Stephens, Nicole M

    2017-12-01

    Understanding the sources of the social class achievement gap in education is an important step toward ensuring that education serves its purpose as an engine of social mobility. The goal of the current article is to provide a brief overview of the sources of the social class achievement gap as well as interventions aimed at closing this gap. We outline three major sources of the social class achievement gap-individual skills, structural conditions, and people's processes of meaning-making, or construals-and the interventions that target them. While all of these interventions can effect change, we propose that interventions will be most effective when tailored to fit the specific needs of students and the context in which they are delivered. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Evaluating the benefits of government funded R & D aimed at the private sector

    Science.gov (United States)

    Greenberg, J. S.

    1977-01-01

    Federal funding of technological research and development is discussed with regard to the procedures for an economic analysis with the goals of (1) determining when the public sector should invest in a research and development program, (2) evaluating the likelihood of private sector participation in terms of public sector participation, and (3) considering the major factors in the formulation of a research and development program in terms of defining initiatives. Public sector investments are evaluated, noting procedures for determining whether benefits exceed costs. The role of the public sector research and development planning is described, considering the procedure for private sector implementation decisions and a methodology for evaluating the possibility of private sector commercialization. The economic value of the public sector research and development program is presented with attention given to a specific case of NASA-sponsored research and development aimed toward the commercialization of new public communications services.

  11. The Research Site Vrchslatina – an experimental design and the main aims

    Directory of Open Access Journals (Sweden)

    Konôpka Bohdan

    2013-09-01

    Full Text Available The research site “Vrchslatina” was established in the spring of 2009 with the aim of studying production processes and the structure of net primary productivity in young forest stands. The beech and spruce stands grown at the site were selected because they originated from natural regeneration and are nearly of the same age. In 2009, we established 5 research plots in each stand with the aim of measuring basic tree characteristics. Moreover, we excavated entire trees to construct allometric relations for the specific tree compartments. In the consecutive years (2010, 2011 and 2012, we also included grass communities dominated by Calamagrostis epigejos in our studies. Besides studying production processes of all tree compartments (i.e. for trees: foliages, branches, stem, coarse and fine roots, for grasses and herbs: below- and above-ground parts, we monitored several atmospheric characteristics, followed by soil characteristics and eventually added a measurement of soil respiration. The results indicated that forest stands (even though they were in their initial growth stages sequestrated much more carbon than the grass communities. Moreover, we proved the considerable influence of climatic conditions (especially the sum of precipitation in the particular years for net primary productivity.

  12. VALUE JUDGMENTS ON MEANING AND AIMS OF USING GAMES GIVEN BY PRESCHOOL TEACHERS

    Directory of Open Access Journals (Sweden)

    Inessa V. Usoltseva

    2015-01-01

    Full Text Available The aim of the presented article is to understand value, aims and practical aspects (frequency, diversity, etc. of using games by preschool teachers with different levels of education.Methods. In the conducted survey, 308 preschool teachers answered a questionnaire developed by leading researcher in ethnopedagogy of play V. M. Grigoriev. Examinees were divided into three groups different in educational level (undergraduated, graduated from college, specialized secondary education. The data were analyzed by comparing value judgments about meaning and aims of using games given by preschool teachers with different levels of education. Also value judgments were compared with practical aspects (frequency, diversity, etc. of the use of games in teachers’ professional work, and with their degree of satisfaction with it. Special attention was paid to the usage of ethno games. The analysis was done out in the program stаstistica 5.0 v and using the methods of nonparametric statistics.Results. The results have showed statistically significant differences between value judgments given by preschool teachers with different levels of education on values of games for developing various children personal qualities, frequency and diversity of use of different types of games. Problems in practical application of national games (Russian national games, games of the people of Russia and people of other countries, international games are designated.Scientific novelty. The author is the first to state the data about divergence influence in valuable representations and purposes of teachers of preschool centres on potential use of game technologies in daily work, and that is reflected in education productivity of younger children; wherein the game is the main activity. Specificity of national games in teaching is shown.Practical significance. The paper materials can be useful at the organisation of methodical work in preschool educational institutions, and by

  13. [Peculiarities and aims of first aid training in the road haulage sector].

    Science.gov (United States)

    Rosso, G L; Bruno, Santina; Feola, M; Zanelli, R; Corino, P

    2008-01-01

    Four years after the law concerning first aid in the workplace was passed in Italy (inter-ministerial decree 388/2003), which is a useful tool in improving safety at work, it is necessary to organize first aid courses specifically for those working in the road haulage sector which would also be effective in case of traffic accidents. In view of the characteristics of the working environment in this sector (the road) and of the working conditions (generally workers are isolated and far from the company's headquarters), it would be necessary to organize ad hoc first aid courses at the workplace for the category of professional drivers. The aim of this article is to discuss some possible organizational aspects of first aid in the road haulage sector, such as: number of workers responsible for first aid, how to train workers for specific risks of traffic accidents, the requirements for teachers responsible for first aid and course targets that must be achieved. A good level of training, achieved during the first aid course at the workplace, might therefore be useful to improve road safety and increase the quality of basic and advanced first aid in road traffic injuries.

  14. In vitro metabolism of testosterone in the horse liver and involvement of equine CYPs 3A89, 3A94 and 3A95.

    Science.gov (United States)

    Schmitz, A; Zielinski, J; Dick, B; Mevissen, M

    2014-08-01

    Testosterone (TES) 6-β-hydroxylation is a significant metabolic step in the biotransformation of TES in human liver microsomes and reflects cytochrome P450 (CYP) 3A4/5 specific metabolic activity. Several CYP3A enzymes have been annotated in the horse genome, but functional characterization is missing. This descriptive study investigates TES metabolism in the horse liver in vitro and the qualitative contribution of three CYP3A isoforms of the horse. Metabolism of TES was investigated by using equine hepatocyte primary cultures and liver microsomes. Chemical inhibitors were used to determine the CYPs involved in TES biotransformation in equine microsomes. Single CYPs 3A89, 3A94, and 3A95, recombinantly expressed in V79 hamster lung fibroblasts, were incubated with TES and the fluorescent metabolite 7-benzyloxy-4-trifluoromethylcoumarin (BFC). The effect of ketoconazole and troleandomycin was evaluated on single CYPs. Testosterone metabolites were analyzed by HPLC and confirmed by GC/MS. In hepatocyte primary cultures, the most abundant metabolite was androstenedione (AS), whereas in liver microsomes, 6-β-hydroxytestosterone showed the largest peak. Formation of 6-β-hydroxytestosterone and 11-β-hydroxytestosterone in liver microsomes was inhibited by ketoconazole, troleandomycin, and quercetin. Equine recombinant CYP3A95 catalyzed 11-β-hydroxylation of testosterone (TES). Metabolism of BFC was significantly inhibited by ketoconazole in CYP3A95, whereas troleandomycin affected the activities of CYP3A94 and CYP3A95. Both inhibitors had no significant effect on CYP3A89. Metabolic reactions and effects of inhibitors differed between the equine CYP3A isoforms investigated. This has to be considered in future in vitro studies. © 2014 John Wiley & Sons Ltd.

  15. Interventions aimed at increasing research use in nursing: a systematic review

    Directory of Open Access Journals (Sweden)

    Moore Katherine

    2007-05-01

    nursing, and the evidence to support or refute specific interventions is inconclusive. To advance the field, we recommend that investigators: (1 use theoretically informed interventions to increase research use, (2 measure research use longitudinally using theoretically informed and psychometrically sound measures of research use, as well as, measuring patient outcomes relevant to the intervention, and (3 use more robust and methodologically sound study designs to evaluate interventions. If investigators aim to establish a link between using research and improved patient outcomes they must first identify those interventions that are effective at increasing research use.

  16. Characterization of the genetic variation present in CYP3A4 in three South African populations

    Science.gov (United States)

    Drögemöller, Britt; Plummer, Marieth; Korkie, Lundi; Agenbag, Gloudi; Dunaiski, Anke; Niehaus, Dana; Koen, Liezl; Gebhardt, Stefan; Schneider, Nicol; Olckers, Antonel; Wright, Galen; Warnich, Louise

    2013-01-01

    The CYP3A4 enzyme is the most abundant human cytochrome P450 (CYP) and is regarded as the most important enzyme involved in drug metabolism. Inter-individual and inter-population variability in gene expression and enzyme activity are thought to be influenced, in part, by genetic variation. Although Southern African individuals have been shown to exhibit the highest levels of genetic diversity, they have been under-represented in pharmacogenetic research to date. Therefore, the aim of this study was to identify genetic variation within CYP3A4 in three South African population groups comprising of 29 Khoisan, 65 Xhosa and 65 Mixed Ancestry (MA) individuals. To identify known and novel CYP3A4 variants, 15 individuals were randomly selected from each of the population groups for bi-directional Sanger sequencing of ~600 bp of the 5′-upstream region and all thirteen exons including flanking intronic regions. Genetic variants detected were genotyped in the rest of the cohort. In total, 24 SNPs were detected, including CYP3A4*12, CYP3A4*15, and the reportedly functional CYP3A4*1B promoter polymorphism, as well as two novel non-synonymous variants. These putatively functional variants, p.R162W and p.Q200H, were present in two of the three populations and all three populations, respectively, and in silico analysis predicted that the former would damage the protein product. Furthermore, the three populations were shown to exhibit distinct genetic profiles. These results confirm that South African populations show unique patterns of variation in the genes encoding xenobiotic metabolizing enzymes. This research suggests that population-specific genetic profiles for CYP3A4 and other drug metabolizing genes would be essential to make full use of pharmacogenetics in Southern Africa. Further investigation is needed to determine if the identified genetic variants influence CYP3A4 metabolism phenotype in these populations. PMID:23423246

  17. Life With and Without Coding: Two Methods for Early-Stage Data Analysis in Qualitative Research Aiming at Causal Explanations

    NARCIS (Netherlands)

    Gläser, Jochen; Laudel, Grit

    2013-01-01

    Qualitative research aimed at "mechanismic" explanations poses specific challenges to qualitative data analysis because it must integrate existing theory with patterns identified in the data. We explore the utilization of two methods—coding and qualitative content analysis—for the first steps in the

  18. Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis.

    Science.gov (United States)

    Jiang, Yang; Cao, Yuan; Wang, Yongbin; Li, Wei; Liu, Xinyi; Lv, Yixuan; Li, Xiaoling; Mi, Jun

    2017-01-01

    Cysteine is an essential amino acid for infants, aged people as well as patients with metabolic disorders. Although the thiol group of cysteine side chain is active in oxidative reactions, the role of cysteine in cancer remains largely unknown. Here, we report that the expression level of the solute carrier family 3, member 1 (SLC3A1), the cysteine carrier, tightly correlated with clinical stages and patients' survival. Elevated SLC3A1 expression accelerated the cysteine uptake and the accumulation of reductive glutathione (GSH), leading to reduced reactive oxygen species (ROS). ROS increased the stability and activity of PP2Ac, resulting in decreased AKT activity. Hence, SLC3A1 activated the AKT signaling through inhibiting PP2A phosphatase activity. Consistently, overexpression of SLC3A1 enhanced tumorigenesis of breast cancer cells, whereas blocking SLC3A1 either with specific siRNA or SLC3A1 specific inhibitor sulfasalazine suppressed tumor growth and also abolished dietary NAC-promoted tumor growth. Collectively, our data demonstrate that SLC3A1 promotes cysteine uptake and determines cellular response to antioxidant N-acetylcysteine, suggesting SLC3A1 is a potential therapeutic target for breast cancer.

  19. The persuasive aims of Metal Gear Solid: A discourse theoretical approach to the study of argumentation in video games

    DEFF Research Database (Denmark)

    Stamenkovic, Dusan; Jacevic, Milan; Wildfeuer, Janina

    2017-01-01

    The paper is aimed at proving the hypothesis that multimodal construction in video games can follow specific discursive aims in the process of persuading game players. In order to prove this, we have performed a multifaceted analysis which elaborated the ways in which different modalities...... in a representative video game combine so as to convince the player to act, play, and perhaps think accordingly. The multimodal approach employed in the paper combines the notion of discourse aims and the rhetorical and argumentative structure of Metal Gear Solid (Kojima, 1998), and analyses different narrative...... strategies and verbal cues, as well as the overall interface, control, and gameplay. The results suggest that verbal and textual cues combine with audio-visual elements and highly specific gameplay strategies in order to refrain the player from killing enemies. This might indicate that video games are likely...

  20. How specific is specific self-efficacy?

    DEFF Research Database (Denmark)

    Nielsen, Tine; Makransky, Guido; Vang, Maria Louison

    2017-01-01

    Self-efficacy is an important and much used construct in psychology and social science studies. The validity of the measurements used is not always sufficiently evaluated. The aim was to evaluate the psychometric properties of the Danish translation of the self-efficacy subscale of The Motivated...... academic learning self-efficacy (SAL-SE) and specific academic exam self-efficacy (SAE-SE), each scale being measurement invariant relative to age, Gender, admission method and specific course targeted. Furthermore, significant and relevant differences between the SAL-SE and SAE-SE scores dependent...... on university and admission method were found, and these results were replicated with two further samples. The SAL-SE and SAE-SE scales hold promise for more detailed studies of student self-efficacy....

  1. HRT Specification

    CERN Document Server

    Möller, M

    1996-01-01

    In the context of the AIS Project (Advanced Informatics Systems for administration and management) a study has been conducted that resulted in the definition of a high level information systems model. Thirteen proposed systems were defined for detailed analysis. The Finance, Foundation, Human Resources, Logistics and Purchasing areas have been studied in detail. These studies have lead to the purchase and implementation of the ORIAC and SIRIAC packages, the Foundation database, the Oracle HR package, the Triton package and EDH and BHT. This specification describes the Human Resources Toolkit (HRT) intended to be used for accessing data in the HR and Foundation systems. This toolkit should help the divisions carry out their Human Resource management, planning and follow-up. It will have extensive report generation capabilities and offer a variety of standard graphs. It should have an easy-to-use graphical user interface and run on the CERN standard desktop platforms.

  2. Older adults' perceptions of technologies aimed at falls prevention, detection or monitoring: a systematic review.

    Science.gov (United States)

    Hawley-Hague, Helen; Boulton, Elisabeth; Hall, Alex; Pfeiffer, Klaus; Todd, Chris

    2014-06-01

    Over recent years a number of Information and Communication Technologies (ICTs) have emerged aiming at falls prevention, falls detection and alarms for use in case of fall. There are also a range of ICT interventions, which have been created or adapted to be pro-active in preventing falls, such as those which provide strength and balance training to older adults in the prevention of falls. However, there are issues related to the adoption and continued use of these technologies by older adults. This review provides an overview of older adults' perceptions of falls technologies. We undertook systematic searches of MEDLINE, EMBASE, CINAHL and PsychINFO, COMPENDEX and the Cochrane database. Key search terms included 'older adults', 'seniors', 'preference', 'attitudes' and a wide range of technologies, they also included the key word 'fall*'. We considered all studies that included older adults aged 50 and above. Studies had to include technologies related specifically to falls prevention, detection or monitoring. The Joanna Briggs Institute (JBI) tool and the Quality Assessment Tool for Quantitative Studies by the Effective Public Health Practice Project (EPHPP) were used. We identified 76 potentially relevant papers. Some 21 studies were considered for quality review. Twelve qualitative studies, three quantitative studies and 6 mixed methods studies were included. The literature related to technologies aimed at predicting, monitoring and preventing falls suggest that intrinsic factors related to older adults' attitudes around control, independence and perceived need/requirements for safety are important for their motivation to use and continue using technologies. Extrinsic factors such as usability, feedback gained and costs are important elements which support these attitudes and perceptions. Positive messages about the benefits of falls technologies for promoting healthy active ageing and independence are critical, as is ensuring that the technologies are simple

  3. Possibilities for using plant extracts added to ruminant feed aimed at improving production results

    Directory of Open Access Journals (Sweden)

    Grdović Svetlana

    2010-01-01

    Full Text Available The use of plant extracts with the objective of improving production results and the quality of food articles of animal origin is an area which is acquiring increasing scientific importance. Numerous investigations carried out so far on ruminants and other species of domestic animals have been aimed at examining specific bioactive matter of plants. The results of these investigations have demonstrated a positive influence on the production results. A large number of data indicate that plant extracts added to animal feed contribute to increasing overall productivity. Furthermore, plant extracts as additives in animal feed have a positive effect also on the health condition of the animals. A large number of plants have characteristics which potentially improve consumption, digestibility and conversion of food, and also growth. Examinations have been performed of the effects of different plant extracts on food consumption, wool growth, growth and composition of the trunk, milk production, reproductive parameters, agents for wool shearing, preventing bloat, methane production, as well as the influence of plants on curbing nematode infestations of ruminants. This work presents a review of scientific investigations of different plant species and their effects on the production characteristics of ruminants. .

  4. Investigation of relationships between AIMS shape properties and VST friction values.

    Science.gov (United States)

    2015-02-01

    A thorough analysis was conducted for AIMS shape properties measured for virgin aggregates, aggregates : polished in the Micro-Deval (MD) for 105 and 210 minutes, and VST friction samples. Excellent repeatability of : AIMS angularity and texture meas...

  5. XML specifications DanRIS

    DEFF Research Database (Denmark)

    2009-01-01

    XML specifications for DanRIS (Danish Registration- og InformationsSystem), where the the aim is: Improved exchange of data Improved data processing Ensuring future access to all gathered data from the year 1999 until now......XML specifications for DanRIS (Danish Registration- og InformationsSystem), where the the aim is: Improved exchange of data Improved data processing Ensuring future access to all gathered data from the year 1999 until now...

  6. DMPD: Fifty years of interferon research: aiming at a moving target. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16979566 Fifty years of interferon research: aiming at a moving target. Vilcek J. I...mmunity. 2006 Sep;25(3):343-8. (.png) (.svg) (.html) (.csml) Show Fifty years of interferon research: aiming... at a moving target. PubmedID 16979566 Title Fifty years of interferon research: aiming at a moving target.

  7. Report on the 8th International Conference on Autonomous Infrastructure, Management, and Security (AIMS 2014)

    NARCIS (Netherlands)

    Sperotto, Anna; Doyen, Guillaume; Latré, Steven; Charalambides, Marinos; Famaey, Jeroen; Velan, Petr; Celeda, Pavel

    This article is a report of the IFIP AIMS 2014, which was held at Masaryk University, Czech Republic from June 30 to July 3, 2014. AIMS 2014 focused on the theme “Monitoring and Securing Virtualized Networks and Services‿. The focus of the 2014 edition of the AIMS conference series was re-defined in

  8. Important treatment aims at the end of life: a nationwide study among GPs.

    NARCIS (Netherlands)

    Claessen, S.J.J.; Echteld, M.A.; Francke, A.L.; Block, L. van den; Donker, G.A.; Deliens, L.

    2012-01-01

    Background: Little is known about treatment aims during the last 3 months of life. Aim: To investigate important treatment aims in the last 3 months of patients' lives in cases of on-sudden death. Design and setting: Mortality follow-back study in the Netherlands. Method: data were collected

  9. Important treatment aims at the end of life: a nationwide study among GPs

    NARCIS (Netherlands)

    Claessen, S.J.J.; Echteld, M.A.; Francke, A.L.; van den Block, L.; Donker, G.A.; Deliens, L.

    2012-01-01

    Background: Little is known about treatment aims during the last 3months of life. Aim: To investigate important treatment aims in the last 3months of patients' lives in cases of non-sudden death. Design and setting: Mortality follow-back study in the Netherlands. Method: Data were collected

  10. 18 CFR 3a.2 - Authority.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Authority. 3a.2 Section 3a.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES NATIONAL SECURITY INFORMATION General § 3a.2 Authority. Official information or...

  11. Age-specific serum prostate specific antigen ranges among ...

    African Journals Online (AJOL)

    Introduction: Serum prostate specific antigen (PSA) levels increase with age and varies among different races and communities. The study was aimed at defining the age-specific reference ranges of serum PSA in our environment. Methods: We evaluated the relationship between age and serum PSA levels and the ...

  12. Validity of the three apathy items of the Geriatric Depression Scale (GDS-3A) in measuring apathy in older persons.

    Science.gov (United States)

    Bertens, Anne Suzanne; Moonen, Justine E F; de Waal, Margot W M; Foster-Dingley, Jessica C; de Ruijter, Wouter; Gussekloo, Jacobijn; van der Mast, Roos C; de Craen, Anton J M

    2017-04-01

    The Geriatric Depression Scale (GDS)-3A, a three-item subset of the GDS-15, is increasingly used as a measure for apathy in research settings to assess factors associating with this neuropsychiatric syndrome. We aimed to assess how accurately the GDS-3A discriminates between presence and absence of apathy in two populations of community-dwelling older persons, using the Apathy Scale as reference standard. Baseline data were used from 427 participants of the Discontinuation of Antihypertensive Treatment in Elderly people (DANTE) Study Leiden and 1118 participants of the PROactive Management Of Depression in the Elderly (PROMODE) Study, all ≥75 years and with available GDS-3A and Apathy Scale measurements. A cut-off score of ≥14 was used for presence of apathy according to the Apathy Scale. Areas under the receiver operating characteristic curve (AUC) were calculated. Based on the likelihood ratios for GDS-3A scores, a cut-off of ≥2 was used for presence of apathy according to the GDS-3A to calculate test characteristics. The AUC was 0.68 (95% confidence interval 0.62-0.73) in the DANTE Study and 0.72 (0.67-0.77) in the PROMODE Study. In the DANTE Study sensitivity was 29.3% (21.4-38.1) and specificity was 88.5% (84.4-91.8), whereas in the PROMODE Study sensitivity was 32.8% (24.5-41.1) and specificity 92.6% (90.9-94.2). Stratification on population characteristics did not yield more favourable test characteristics. The GDS-3A has low sensitivity and high specificity as a measure of apathy in two populations of older persons. Using the GDS-3A in research might yield estimates biassed towards the null in case of non-differential misclassification. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  13. Process evaluation of a web-based intervention aimed at empowerment of disability benefit claimants.

    Science.gov (United States)

    Samoocha, David; Snels, Ingrid A K; Bruinvels, David J; Anema, Johannes R; Kowalczyk, Wojtek; van der Beek, Allard J

    2011-02-16

    The objective of this process evaluation study was to gain insight into the reach, compliance, appreciation, usage barriers, and users' perceived effectiveness of a web-based intervention http://www.wiagesprek.nl. This intervention was aimed at empowerment of disability claimants, prior to the assessment of disability by an insurance physician. Reach was determined by registering claimants exposed to the study's invitation brochures, and by comparing trial participant characteristics with non-participants and nationwide claimant data. Compliance was registered by analyzing weblogs, which were automatically collected during the period of the trial. This made it possible to analyze individual use of the intervention. Appreciation, usage barriers, and users' perceived effectiveness were assessed using an online questionnaire that was sent to participants from the intervention group, 6 weeks after enrolment. Only 9% of the target population enrolled in the internet program. Because of selective enrolment, more females, higher educated claimants, and less ethnical minorities were reached. Compliance was ambiguous: out of the 123 participants randomized into the intervention group, a significant proportion (33%) did not use the intervention at all, while, at the same time, many participants (32%) used the intervention for more than two hours (i.e. in approximately two weeks). Overall satisfaction with the intervention was good. Claimants perceived the intervention most effective in increasing knowledge, while also a fair amount of users perceived the intervention effective in gaining right expectations or being able to communicate better with their physician. The uptake of the intervention http://www.wiagesprek.nl was disappointing. Specifically, the poor reach and compliance of the intervention resulted in a small proportion of the target population using the intervention as intended. Improvements in the implementation process are desirable to increase the reach and

  14. Optimization of the cold processing of 15-15Ti AIM1 austenitic steel cladding tubes

    International Nuclear Information System (INIS)

    Courtin, Laurine

    2015-01-01

    In order to face the next century energy demand growth, the worldwide development of the 4. generation of nuclear reactors is considered. The construction of a sodium-cooled fast reactor prototype (ASTRID) is currently envisaged at the CEA. The reference material selected for the fuel cladding of its first core is the 15-15Ti-AIM1 austenitic steel (Austenitic Improved Material). The goal of this PhD thesis work is to investigate the different ways of optimization for the cold working steps undergone by the claddings during their manufacture in order to improve their swelling resistance. The main investigations are focused on the conditions of the cold-working steps and the thermal treatments applied throughout the shaping of the claddings, especially of the last solution annealing treatment. The effects of these parameters on the microstructure are investigated (structural refinement, precipitation and the additive elements dissolution and arrangement of the dislocations). This study is divided into three main steps: An analysis of the fabrication routes applied in the past along with the study of the 'cold-work' and the thermal treatments conditions; An assessment of new shaping processes, such as the 'cold-pilgering' and the hammering, in order to verify the conformity of the manufactured tubes with respect to the required specifications; An attempt of optimization of the cold-work routes and the microstructure of the final material. The results of microstructure characterization and the mechanical behavior allow envisaging favorably the use of an alternative process such as the cold pilgering to manufacture claddings. (author) [fr

  15. Process evaluation of a web-based intervention aimed at empowerment of disability benefit claimants

    Directory of Open Access Journals (Sweden)

    Anema Johannes R

    2011-02-01

    Full Text Available Abstract Background The objective of this process evaluation study was to gain insight into the reach, compliance, appreciation, usage barriers, and users' perceived effectiveness of a web-based intervention http://www.wiagesprek.nl. This intervention was aimed at empowerment of disability claimants, prior to the assessment of disability by an insurance physician. Methods Reach was determined by registering claimants exposed to the study's invitation brochures, and by comparing trial participant characteristics with non-participants and nationwide claimant data. Compliance was registered by analyzing weblogs, which were automatically collected during the period of the trial. This made it possible to analyze individual use of the intervention. Appreciation, usage barriers, and users' perceived effectiveness were assessed using an online questionnaire that was sent to participants from the intervention group, 6 weeks after enrolment. Results Only 9% of the target population enrolled in the internet program. Because of selective enrolment, more females, higher educated claimants, and less ethnical minorities were reached. Compliance was ambiguous: out of the 123 participants randomized into the intervention group, a significant proportion (33% did not use the intervention at all, while, at the same time, many participants (32% used the intervention for more than two hours (i.e. in approximately two weeks. Overall satisfaction with the intervention was good. Claimants perceived the intervention most effective in increasing knowledge, while also a fair amount of users perceived the intervention effective in gaining right expectations or being able to communicate better with their physician. Conclusions The uptake of the intervention http://www.wiagesprek.nl was disappointing. Specifically, the poor reach and compliance of the intervention resulted in a small proportion of the target population using the intervention as intended. Improvements in the

  16. An interprofessional initiative aimed at creating a common learning resource for the operating room ward.

    Science.gov (United States)

    Torbjörnsson, Eva; Olivecrona, Charlotta; Sonden, Anders

    2018-02-08

    Every semester, the operating room (OR) ward receives students from different educational programmes. Although interprofessional knowledge is essential for OR teamwork, students have traditionally been prepared in an uniprofessional manner, with no focus on interprofessional learning outcomes. This report describes the work process of an interprofessional initiative undertaken to create a common learning resource aimed at preparing students for OR practice. With a focus on interprofessional learning, shared and profession-specific learning outcomes, which are needed to prepare for practice, were identified by an interprofessional faculty. To avoid timetabling and geographic barriers, learning outcomes and constructed learning activities were packaged into an e-module and delivered on-line as an adjunct to existing lectures and workshops. A survey was administered to 4th year medical (n = 42) and 1st year OR nurse students (n = 4) to evaluate their perceptions of the e-module. We found that most learning outcomes from the different syllabuses were common for all professions. The overall response rate of the survey was 59% (27 of 46 students). Eighteen of the 27 responding students had used the learning resource, of which 15 students considered it to be of 'high' or 'very high' value. In summary, this interprofessional initiative resulted in a new common learning resource for the OR, which was used and perceived valuable by a majority of the students. The learning outcomes needed to prepare students from different educational programmes for OR practice are, to a great extent, generic and interprofessional and we thus argue that the interprofessional nature of the faculty was essential for the success of the initiative.

  17. VHDL Specification Methodology from High-level Specification

    OpenAIRE

    M. Benmohammed; S. Merniz

    2005-01-01

    Design complexity has been increasing exponentially this last decade. In order to cope with such an increase and to keep up designers' productivity, higher level specifications were required. Moreover new synthesis systems, starting with a high level specification, have been developed in order to automate and speed up processor design. This study presents a VHDL specification methodology aimed to extend structured design methodologies to the behavioral level. The goal is t...

  18. The influence of CYP3A5 polymorphisms on haloperidol treatment in patients with alcohol addiction

    Directory of Open Access Journals (Sweden)

    Zastrozhin MS

    2017-12-01

    Full Text Available Mikhail Sergeevich Zastrozhin,1,2 Elena Anatolievna Grishina,1 Kristina Anatolievna Ryzhikova,1 Valery Valerievich Smirnov,3 Ludmila Mikhailovna Savchenko,1 Evgeny Alekseevich Bryun,1,2 Dmitry Alekseevich Sychev1 1Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, 2Moscow Research and Practical Centre on Addictions, Moscow Department of Healthcare, 3National Research Center Institute of Immunology, Federal Medical-Biological Agency, Moscow, Russia Background: Isoenzymes CYP2D6 and CYP3A4, the activity of which varies widely, are involved in metabolism of haloperidol and may influence its profile of efficacy and safety.Objective: The primary aim of this study was to estimate the relationship between CYP3A5 gene polymorphism, activity of the CYP3A isoenzyme, and the risk of development of adverse drug reactions by haloperidol in patients with alcohol abuse.Methods: Sixty-six male alcohol-addicted patients participated in the study. The safety of haloperidol was evaluated by Udvalg for Kliniske Undersogelser Side Effect Rating Scale (UKU and Simpson–Angus Scale for extrapyramidal symptoms (SAS. The activity of CYP3A was evaluated by determining the concentrations of an endogenous substrate of this isoenzyme (cortisol and its urinary metabolite (6-beta-hydroxycortisol, 6-B-HC. Genotyping of CYP3A5*3 was performed by real-time polymerase chain reaction with allele-specific hybridization.Results: The frequency of A-allele occurrence in Russian population was very poor (2.27%. CYP3A5*3 polymorphism had no influence on safety profile indicators of haloperidol (UKU scale: p=0.55, SAS scale: p=0.64. In addition, there was no statistical significant difference between the values of indexes of the metabolic ratio (6-B-HC/cortisol in groups with different genotypes of CYP3A5*3: GG 5.00 (3.36; 6.39 vs AG 5.26 (2.10; 6.78 (p=0.902.Conclusion: The frequency of A-allele occurrence of CYP3A5*3 in Russian

  19. Online decision support based on modeling with the aim of increased irrigation efficiency

    Science.gov (United States)

    Dövényi-Nagy, Tamás; Bakó, Károly; Molnár, Krisztina; Rácz, Csaba; Vasvári, Gyula; Nagy, János; Dobos, Attila

    2015-04-01

    The significant changes in the structure of ownership and control of irrigation infrastructure in the past decades resultted in the decrease of total irrigable and irrigated area (Szilárd, 1999). In this paper, the development of a model-based online service is described whose aim is to aid reasonable irrigation practice and increase water use efficiency. In order to establish a scientific background for irrigation, an agrometeorological station network has been built up by the Agrometeorological and Agroecological Monitoring Centre. A website has been launched in order to provide direct access for local agricultural producers to both the measured weather parameters and results of model based calculations. The public site provides information for general use, registered partners get a handy model based toolkit for decision support at the plot level concerning irrigation, plant protection or frost forecast. The agrometeorological reference station network was established in the recent years by the Agrometeorological and Agroecological Monitoring Centre and is distributed to cover most of the irrigated cropland areas of Hungary. From the spatial aspect, the stations have been deployed mainly in Eastern Hungary with concentrated irrigation infrastructure. The meteorological stations' locations have been carefully chosen to represent their environment in terms of soil, climatic and topographic factors, thereby assuring relevant and up-to-date input data for the models. The measured parameters range from classic meteorological data (air temperature, relative humidity, solar irradiation, wind speed etc.) to specific data which are not available from other services in the region, such as soil temperature, soil water content in multiple depths and leaf wetness. In addition to the basic grid of reference stations, specific stations under irrigated conditions have been deployed to calibrate and validate the models. A specific modeling framework (MetAgro) has been developed

  20. Semaphorin3A: A Potential Therapeutic Tool for Lupus Nephritis

    Directory of Open Access Journals (Sweden)

    Jacob Bejar

    2018-04-01

    Full Text Available BackgroundThe immune regulatory properties of semaphorin3A (sema3A (both innate and adaptive are well established in many in vitro studies. The injection of sema3A into a mice model of rheumatoid arthritis was proven to be highly beneficial, both in attenuating clinical symptoms and in decreasing inflammatory mechanisms.ObjectivesThis study was designed in order to assess the possible therapeutic benefits of sema3A following its injection into female NZB/W mice.MethodsForty-eight NZB/W mice were recruited for this study. Thirty mice were treated as a “prevention group” and 18 were used as a “treatment group.” Eight-week-old mice were acclimated and then divided into the two abovementioned groups.ResultsThe injection of sema3A into young mice (at week 12 before the onset of disease (the prevention group delayed the appearance of proteinuria. Here, the median time to severe proteinuria was 110 days, 95% CI: 88–131. However, in mice in which the empty vector was injected, the median time to severe proteinuria was 63 days, 95% CI: 0–139. sema3A treatment, significantly reduced renal damage, namely, it prevented the deposition of immune complexes in the glomeruli. When sema3A was injected at the onset of proteinuria (the treatment group, aiming to treat rather than to prevent disease in these mice, survival was increased and the deterioration of proteinuria was delayed.ConclusionSemaphorin3A is highly beneficial in reducing lupus nephritis in NZB/W mice. It delays the appearance and deterioration of proteinuria, and increases the survival rates in these mice. The regulatory mechanisms of sema3A involve both innate and adaptive immune responses. Further studies will establish the idea of applying sema3A in the treatment of lupus nephritis.

  1. Absent in melanoma 2 (AIM2) in rat dental pulp mediates the inflammatory response during pulpitis.

    Science.gov (United States)

    Wang, Yafei; Zhai, Shafei; Wang, Haijing; Jia, Qian; Jiang, Wenkai; Zhang, Xiao; Zhang, Ansheng; Liu, Jun; Ni, Longxing

    2013-11-01

    In recent years, the inflammasome has been determined to play an important role in inflammatory diseases. However, the role of the inflammasome in pulpitis remains unclear. Absent in melanoma 2 (AIM2) is a type of inflammasome that recognizes cytosolic double stranded DNA and forms a caspase-1-activating inflammasome with apoptosis-associated speck-like protein containing a caspase activating recruiting domain. In this study, we determined whether AIM2 was expressed in pulp cells and defined the role of AIM2 in the initiation of inflammation within the dental pulp. In the in vivo study, the right maxillary molars from male adult Sprague-Dawley rats (250-350 g) were exposed to the pulp. In the in vitro study, the pulp cells isolated from the mandibular incisors of the Sprague-Dawley rats (2 weeks) were conventionally cultured. Immunofluorescence staining was used to determine the expression and distribution of AIM2 in the rat dental pulp tissues and cells in the presence or absence of inflammatory stimulation. Western blotting and real-time polymerase chain reaction were performed to determine whether there was a correlation between AIM2 expression levels and inflammation both in vivo and in vitro. In healthy dental pulp tissues and cells, AIM2 was only detected in the odontoblast layer. Stimulation significantly increased AIM2 expression in both the dental pulp tissues and cultured cells. The mRNA and protein levels of AIM2 were significantly up-regulated in response to inflammatory stimulation in a dose-dependent manner. Moreover, we also found that AIM2 expression correlated with interleukin-1 levels. These results reveal a direct relationship between the AIM2 inflammasome and pulpitis. Our study demonstrates that AIM2 is expressed in dental pulp tissues and mediates the inflammatory response during pulpitis. Therapeutic interventions aimed at reducing AIM2 expression may be beneficial in the treatment of pulpitis. Copyright © 2013 American Association of

  2. Strong induction of AIM2 expression in human epidermis in acute and chronic inflammatory skin conditions.

    Science.gov (United States)

    de Koning, Heleen D; Bergboer, Judith G M; van den Bogaard, Ellen H; van Vlijmen-Willems, Ivonne M J J; Rodijk-Olthuis, Diana; Simon, Anna; Zeeuwen, Patrick L J M; Schalkwijk, Joost

    2012-12-01

    Absent in melanoma 2 (AIM2) is a double-stranded DNA receptor, and its activation initiates an interleukin-1 beta processing inflammasome. AIM2 is implicated in host defense against several pathogens, but could hypothetically also contribute to autoinflammatory or autoimmune diseases, such as is the case for NLRP3. Using thoroughly characterised antibodies, we analysed AIM2 expression in human tissues and primary cells. A strong epidermal upregulation of AIM2 protein expression was observed in several acute and chronic inflammatory skin disorders, such as psoriasis, atopic dermatitis, venous ulcera, contact dermatitis, and experimental wounds. We also found AIM2 induction by interferon-gamma in submerged and three-dimensional in vitro models of human epidermis. Our data highlight the dynamics of epidermal AIM2 expression, showing Langerhans cell and melanocyte-restricted expression in normal epidermis but a pronounced induction in subpopulations of epidermal keratinocytes under inflammatory conditions. © 2012 John Wiley & Sons A/S.

  3. AIM Photonics: Tomorrow’s Technology at the Speed of Light

    Science.gov (United States)

    2016-09-01

    AIM) Integrated Photonics , where he focuses on creating new AIM business opportunities and is responsible for the effective and efficient operation of...AIM’s programs, including the State University of New York (SUNY) Polytechnic Institute’s strategic 300-millimeter (mm) integrated photonic ...design automation companies AIM Photonics Tomorrow’s Technology at the Speed of Light Michael Liehr Defense AT&L: September-October 2010 386

  4. Advanced Integrated Multi-Sensor Surveillance (AIMS): Mission, Function, Task Analysis

    Science.gov (United States)

    2007-06-01

    DEFENCE DÉFENSE & Advanced Integrated Multi-sensor Surveillance (AIMS) Mission, Function, Task Analysis Kevin Baker and Gord Youngson CAE...Canada This page intentionally left blank. Advanced Integrated Multi-sensor Surveillance (AIMS) Mission, Function, Task Analysis Kevin Baker...les principaux opérateurs. Il est recommandé d’en tenir compte durant l’intégration du système AIMS aux projets du FWSAR et du CP-140 du PIMPA

  5. Advanced Integrated Multi-sensor Surveillance (AIMS). Mission, Function, Task Analysis

    Science.gov (United States)

    2007-06-01

    Defence R&D Canada – Atlantic DEFENCE DÉFENSE & Advanced Integrated Multi-sensor Surveillance (AIMS) Mission, Function, Task Analysis Kevin Baker and...sensor Surveillance (AIMS) Mission, Function, Task Analysis Kevin Baker Gord Youngson CAE Professional Services CAE Professional Services 1135...d’en tenir compte durant l’intégration du système AIMS aux projets du FWSAR et du CP-140 du PIMPA. Baker, K. and Youngson, G. 2007. Advanced

  6. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture

    OpenAIRE

    Harner, Max Emanuel; Unger, Ann-Katrin; Izawa, Toshiaki; Walther, Dirk M; Ozbalci, Cagakan; Geimer, Stefan; Reggiori, Fulvio; Brügger, Britta; Mann, Matthias; Westermann, Benedikt; Neupert, Walter; Reggiori, Fulvio

    2014-01-01

    Structure and function of mitochondria are intimately linked. In a search for components that participate in building the elaborate architecture of this complex organelle we have identified Aim24, an inner membrane protein. Aim24 interacts with the MICOS complex that is required for the formation of crista junctions and contact sites between inner and outer membranes. Aim24 is necessary for the integrity of the MICOS complex, for normal respiratory growth and mitochondrial ultrastructure. Mod...

  7. Angelman Syndrome Due to UBE3A Gene Mutation.

    Science.gov (United States)

    Goswami, Jyotindra Narayan; Sahu, Jitendra Kumar; Singhi, Pratibha

    2017-12-18

    A 12-y-old boy presented with developmental delay, autism, epilepsy, limb tremors and behavioral problems which posed a diagnostic challenge. Though his clinical profile and electroencephalogram were suggestive of Angelman syndrome, initial genetic tests were unyielding. Exome sequencing revealed a previously unreported mutation of Ubiquitin Protein Ligase E3A (UBE3A) gene, confirming the diagnosis of Angelman syndrome. The case is aimed to sensitize pediatricians about Angelman syndrome and to highlight the role of sequential investigations in establishing the diagnosis.

  8. Internet Use with Learning Aim: Views of German Language Pre-Service Teachers

    Science.gov (United States)

    Yucel, Mukadder Seyhan

    2011-01-01

    The aim of this study is to indicate the views of teacher candidates of German Language Department at Education Faculty, Trakya University about the use of internet with the aim of learning. This study was designed as phenomenology which is one of the qualitative research methods. The study data were obtained via semi-constructed interview…

  9. AIMS, une expérience transformatrice | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    22 janv. 2014 ... Nous avons rebaptisé AIMS « African Institute for Missing Sleep » (institut africain du manque de sommeil), parce que nous travaillions toute la nuit. Nous avions des ordinateurs à notre disposition, nous étions très motivés. Le Malawien Richard Junganiko Munthali participe à l'AIMS Industry Initiative, qui ...

  10. Flourishing as the Aim of Education: Towards an Extended, "Enchanted" Aristotelian Account

    Science.gov (United States)

    Kristjánsson, Kristján

    2016-01-01

    Flourishing, understood along Aristotelian or quasi-Aristotelian lines as objective "eudaimonic" well-being, is re-emerging as a paradigm for the ideal aim of education in the 21st century. This paper aims to venture beyond the current accounts and Aristotle's own, by arguing that both suffer from a kind of "flatness" or…

  11. What are important treatment aims in the last three months of life?

    NARCIS (Netherlands)

    Claessen, S.J.J.; Echteld, M.A.; Francke, A.L.; Block, L. van den; Donker, G.A.; Deliens, L.

    2011-01-01

    Research aims: Nowadays, palliative care is considered as a continuum from the diagnosis of a life-threatening illness until death. Aim of this study was to test the assumption of a decreasing importance of curative or life-prolonging treatments and increasing importance of palliative treatment

  12. Evaluation of Heliostat Standby Aiming Strategies to Reduce Avian Flux Hazards and Impacts on Operational Performance

    Energy Technology Data Exchange (ETDEWEB)

    Wendelin, Timothy J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Ho, Clifford K. [Sandia National Laboratories; Horstman, Luke [Sandia National Laboratories

    2017-06-03

    This paper presents a study of alternative heliostat standby aiming strategies and their impact on avian flux hazards and operational performance of a concentrating solar power plant. A mathematical model was developed that predicts the bird-feather temperature as a function of solar irradiance, thermal emittance, convection, and thermal properties of the feather. The irradiance distribution in the airspace above the Ivanpah Unit 2 heliostat field was simulated using a ray-trace model for two different times of the day, four days of the year, and nine different standby aiming strategies. The impact of the alternative aiming strategies on operational performance was assessed by comparing the heliostat slew times from standby position to the receiver for the different aiming strategies. Increased slew times increased a proxy start-up time that reduced the simulated annual energy production. Results showed that spreading the radial aim points around the receiver to a distance of ~150 m or greater reduced the hazardous exposure times that the feather temperature exceeded the hazard metric of 160 degrees C. The hazardous exposure times were reduced by ~23% and 90% at a radial spread of aim points extending to 150 m and 250 m, respectively, but the simulated annual energy production decreased as a result of increased slew times. Single point-focus aiming strategies were also evaluated, but these strategies increased the exposure hazard relative to other aiming strategies.

  13. Strong induction of AIM2 expression in human epidermis in acute and chronic inflammatory skin conditions

    NARCIS (Netherlands)

    de Koning, H.D.; Bergboer, J.G.M.; van den Bogaard, E.H.; van Vlijmen-Willems, I.M.; Rodijk-Olthuis, D.; Simon, A.; Zeeuwen, P.L.J.M.; Schalkwijk, J.

    2012-01-01

    Absent in melanoma 2 (AIM2) is a double-stranded DNA receptor, and its activation initiates an interleukin-1 beta processing inflammasome. AIM2 is implicated in host defense against several pathogens, but could hypothetically also contribute to autoinflammatory or autoimmune diseases, such as is the

  14. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture

    NARCIS (Netherlands)

    Harner, Max Emanuel; Unger, Ann-Katrin; Izawa, Toshiaki; Walther, Dirk M; Ozbalci, Cagakan; Geimer, Stefan; Reggiori, Fulvio; Brügger, Britta; Mann, Matthias; Westermann, Benedikt; Neupert, Walter; Reggiori, Fulvio

    2014-01-01

    Structure and function of mitochondria are intimately linked. In a search for components that participate in building the elaborate architecture of this complex organelle we have identified Aim24, an inner membrane protein. Aim24 interacts with the MICOS complex that is required for the formation of

  15. Failed culture change aimed at more service provision: A test of three agentic factors

    NARCIS (Netherlands)

    Jorritsma, P.Y.; Wilderom, Celeste P.M.

    2012-01-01

    Purpose – Headquarters managers of a medium-sized manufacturing company initiated a culture change in five of their dispersed wholesale units. The aim was for more external service quality. This paper aims to report the results of a test of three hypotheses, shedding light on the behavior of the

  16. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture.

    Science.gov (United States)

    Harner, Max Emanuel; Unger, Ann-Katrin; Izawa, Toshiaki; Walther, Dirk M; Ozbalci, Cagakan; Geimer, Stefan; Reggiori, Fulvio; Brügger, Britta; Mann, Matthias; Westermann, Benedikt; Neupert, Walter

    2014-01-01

    Structure and function of mitochondria are intimately linked. In a search for components that participate in building the elaborate architecture of this complex organelle we have identified Aim24, an inner membrane protein. Aim24 interacts with the MICOS complex that is required for the formation of crista junctions and contact sites between inner and outer membranes. Aim24 is necessary for the integrity of the MICOS complex, for normal respiratory growth and mitochondrial ultrastructure. Modification of MICOS subunits Mic12 or Mic26 by His-tags in the absence of Aim24 leads to complete loss of cristae and respiratory complexes. In addition, the level of tafazzin, a cardiolipin transacylase, is drastically reduced and the composition of cardiolipin is modified like in mutants lacking tafazzin. In conclusion, Aim24 by interacting with the MICOS complex plays a key role in mitochondrial architecture, composition and function. DOI: http://dx.doi.org/10.7554/eLife.01684.001.

  17. The AIM2 inflammasome is critical for innate immunity against Francisella tularensis

    Science.gov (United States)

    Fernandes-Alnemri, Teresa; Yu, Je-Wook; Juliana, Christine; Solorzano, Leobaldo; Kang, Seokwon; Wu, Jianghong; Datta, Pinaki; McCormick, Margaret; Huang, Lan; McDermott, Erin; Eisenlohr, Laurence; Landel, Carlisle P.; Alnemri, Emad S.

    2010-01-01

    Summary Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1 β (IL-1 β) and IL-18. We elucidate here how host macrophages recognize Francisella and elicit this pro-inflammatory response. Using mice deficient in the DNA-sensing inflammasome component AIM2, we demonstrate here that AIM2 is required for sensing Francisella. AIM2-deficient mice were extremely susceptible to Francisella infection with higher mortality and bacterial burden compared to wild-type mice. Caspase-1, activation, IL-1β secretion and cell death were absent in Aim2−/− macrophages in response to Francisella infection or presence of cytoplasmic DNA. This study identifies AIM2 as a crucial sensor of F. tularensis infection, and provides genetic proof for its critical role in the host innate immunity to intracellular pathogens. PMID:20351693

  18. AIMS baby movement scale application in high-risk infants early intervention analysis.

    Science.gov (United States)

    Wang, Y; Shi, J-P; Li, Y-H; Yang, W-H; Tian, Y-J; Gao, J; Li, S-J

    2016-05-01

    We investigated the application of Alberta Infant Motor Scale (AIMS) in screening motor development delay in the follow-up of high-risk infants who were discharged from NICU, to explain the state of infants' motor development and propose early individualized intervention. The study design was a randomized, single-blind trial by selecting patients between April 2015 and November 2015 in our hospital, children nerve recovery branch clinics and 77 cases of high-risk infants. We randomly divided the patients into observation group (39 cases) and control group (38 cases). To evaluate the application with AIMS, observation group was based on evaluation results for the first time to give rehabilitation training plan making, early intervention, control group according to the growth and development milestone in order to guide parents to take family training interval of 3 months. While comparing the two groups of high-risk infants before the intervention, the months of age, gender, risk factors, it was found that the AIMS scores, each position AIMS scores did not show a significant difference in percentile (p>0.05). There was also no significant difference between two groups in the seat and stand AIMS scores before and after intervention (p>0.05). However, the comparison of two groups of high-risk infants after intervention in comparison showed that the observation group supine AIMS scores and AIMS scores were significantly higher than the control group (p<0.05). Prone position AIMS scores observation group was also significantly higher than that of the control group (p<0.01). The corresponding percentile for two groups after the intervention of AIMS scores was less than 10% of cases, which was significantly lower in the observation group (p<0.01). AIMS can predict the development delay in high-risk infants, for improving the early hypernymic diagnosis and intervention.

  19. How pragmatic is it? Lessons learned using PRECIS and RE-AIM for determining pragmatic characteristics of research.

    Science.gov (United States)

    Gaglio, Bridget; Phillips, Siobhan M; Heurtin-Roberts, Suzanne; Sanchez, Michael A; Glasgow, Russell E

    2014-08-28

    The need for high-quality evidence that is applicable in real-world, routine settings continues to increase. Pragmatic trials are designed to evaluate the effectiveness of interventions in real-world settings, whereas explanatory trials aim to test whether an intervention works under optimal situations. There is a continuum between explanatory and pragmatic trials. Most trials have aspects of both, making it challenging to label and categorize a trial and to evaluate its potential for translation into practice. We summarize our experience applying the Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) combined with external validity items based on the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework to three studies to provide a more robust and comprehensive assessment of trial characteristics related to translation of research. We summarize lessons learned using domains from the combined frameworks for use in study planning, evaluating specific studies, and reviewing the literature and make recommendations for future use. A variety of coders can be trained to use the PRECIS and RE-AIM domains. These domains can also be used for diverse purposes, content areas, and study types, but are not without challenges. Both PRECIS and RE-AIM domains required modification in two of the three studies to evaluate and rate domains specific to study type. Lessons learned involved: dedicating enough time for training activities related to the domains; use of reviewers with a range of familiarity with specific study protocols; how to best adapt ratings that reflect complex study designs; and differences of opinion regarding the value of creating a composite score for these criteria. Combining both frameworks can specifically help identify where and how a study is and is not pragmatic. Using both PRECIS and RE-AIM allows for standard reporting of key study characteristics related to pragmatism and translation. Such measures should be used

  20. Thirty years of artificial intelligence in medicine (AIME) conferences: A review of research themes.

    Science.gov (United States)

    Peek, Niels; Combi, Carlo; Marin, Roque; Bellazzi, Riccardo

    2015-09-01

    Over the past 30 years, the international conference on Artificial Intelligence in MEdicine (AIME) has been organized at different venues across Europe every 2 years, establishing a forum for scientific exchange and creating an active research community. The Artificial Intelligence in Medicine journal has published theme issues with extended versions of selected AIME papers since 1998. To review the history of AIME conferences, investigate its impact on the wider research field, and identify challenges for its future. We analyzed a total of 122 session titles to create a taxonomy of research themes and topics. We classified all 734 AIME conference papers published between 1985 and 2013 with this taxonomy. We also analyzed the citations to these conference papers and to 55 special issue papers. We identified 30 research topics across 12 themes. AIME was dominated by knowledge engineering research in its first decade, while machine learning and data mining prevailed thereafter. Together these two themes have contributed about 51% of all papers. There have been eight AIME papers that were cited at least 10 times per year since their publication. There has been a major shift from knowledge-based to data-driven methods while the interest for other research themes such as uncertainty management, image and signal processing, and natural language processing has been stable since the early 1990s. AIME papers relating to guidelines and protocols are among the most highly cited. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. A Method for User Centering Systematic Product Development Aimed at Industrial Design Students

    Science.gov (United States)

    Coelho, Denis A.

    2010-01-01

    Instead of limiting the introduction and stimulus for new concept creation to lists of specifications, industrial design students seem to prefer to be encouraged by ideas in context. A new method that specifically tackles human activity to foster the creation of user centered concepts of new products was developed and is presented in this article.…

  2. A Probabilistic Risk Analysis (PRA) of Human Space Missions for the Advanced Integration Matrix (AIM)

    Science.gov (United States)

    Jones, Harry W.; Dillon-Merrill, Robin L.; Thomas, Gretchen A.

    2003-01-01

    The Advanced Integration Matrix (AIM) Project u7ill study and solve systems-level integration issues for exploration missions beyond Low Earth Orbit (LEO), through the design and development of a ground-based facility for developing revolutionary integrated systems for joint human-robotic missions. This paper describes a Probabilistic Risk Analysis (PRA) of human space missions that was developed to help define the direction and priorities for AIM. Risk analysis is required for all major NASA programs and has been used for shuttle, station, and Mars lander programs. It is a prescribed part of early planning and is necessary during concept definition, even before mission scenarios and system designs exist. PRA cm begin when little failure data are available, and be continually updated and refined as detail becomes available. PRA provides a basis for examining tradeoffs among safety, reliability, performance, and cost. The objective of AIM's PRA is to indicate how risk can be managed and future human space missions enabled by the AIM Project. Many critical events can cause injuries and fatalities to the crew without causing loss of vehicle or mission. Some critical systems are beyond AIM's scope, such as propulsion and guidance. Many failure-causing events can be mitigated by conducting operational tests in AIM, such as testing equipment and evaluating operational procedures, especially in the areas of communications and computers, autonomous operations, life support, thermal design, EVA and rover activities, physiological factors including habitation, medical equipment, and food, and multifunctional tools and repairable systems. AIM is well suited to test and demonstrate the habitat, life support, crew operations, and human interface. Because these account for significant crew, systems performance, and science risks, AIM will help reduce mission risk, and missions beyond LEO are far enough in the future that AIM can have significant impact.

  3. 49 CFR 178.36 - Specification 3A and 3AX seamless steel cylinders.

    Science.gov (United States)

    2010-10-01

    ... corresponding strain. (iv) Cross-head speed of the testing machine may not exceed 1/8 inch per minute during... specified test pressure; the sum of two times the maximum tensile stress in the bottom fibers due to bending... when necessary to meet the requirement. (ii) To calculate the maximum longitudinal tensile stress due...

  4. A population-specific uncommon variant in GRIN3A associated with schizophrenia.

    Science.gov (United States)

    Takata, Atsushi; Iwayama, Yoshimi; Fukuo, Yasuhisa; Ikeda, Masashi; Okochi, Tomo; Maekawa, Motoko; Toyota, Tomoko; Yamada, Kazuo; Hattori, Eiji; Ohnishi, Tetsuo; Toyoshima, Manabu; Ujike, Hiroshi; Inada, Toshiya; Kunugi, Hiroshi; Ozaki, Norio; Nanko, Shinichiro; Nakamura, Kazuhiko; Mori, Norio; Kanba, Shigenobu; Iwata, Nakao; Kato, Tadafumi; Yoshikawa, Takeo

    2013-03-15

    Genome-wide association studies have successfully identified several common variants showing robust association with schizophrenia. However, individually, these variants only produce a weak effect. To identify genetic variants with larger effect sizes, increasing attention is now being paid to uncommon and rare variants. From the 1000 Genomes Project data, we selected 47 candidate single nucleotide variants (SNVs), which were: 1) uncommon (minor allele frequency way to discover risk variants with larger effects. Copyright © 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  5. DNA methyltransferase 3A gene polymorphism contributes to daily life stress susceptibility

    Directory of Open Access Journals (Sweden)

    Barliana MI

    2017-12-01

    Full Text Available Melisa I Barliana,1,2 Shintya N Amalya,1 Ivan S Pradipta,3 Sofa D Alfian,3 Arif SW Kusuma,1,2 Tiana Milanda,1,4 Rizky Abdulah3,4 1Department of Biological Pharmacy, Biotechnology Pharmacy Laboratory, 2Pharmacy Services Development Research Center, 3Department of Pharmacology and Clinical Pharmacy, Clinical Pharmacy Laboratory, 4Center for Drug Discovery and Product Development, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia Abstract: Daily life stress markedly affects the response toward stressful stimuli. DNA methy­lation is one of the factors that regulate this response, and is a normal mechanism of somatic cell growth, but its regulatory gene variations may cause alterations in the stress response. The aim of the present study was to investigate genotypic variants of the DNA methyltransferase 3A (DNMT3A gene in 129 healthy subjects and evaluate its association with daily life stress. Blood samples were collected, and genomic DNA was isolated. DNA was amplified using specific tetra primers for DNMT3A (C/T rs11683424 and visualized following 2% agarose gel electrophoresis. The association of DNMT3A genetic variants with daily life stress was analyzed using the Kessler Psychological Distress Scale (K10. We observed that the distribution of subjects with genotype CC (wild type, CT (heteromutant, and TT (homomutant was 13.95%, 81.4%, and 4.65%, respectively. Genetic variations significantly affected the daily life stress condition (p=0.04 in Indonesian healthy subjects, but most of the subjects with the CT phenotype were classified in a stress condition. Keywords: daily life stressor, DNA methylation, epigenetic, Kessler Psychological Distress Scale (K10, rs11683424, DNMT3A

  6. REDUCTION IN ASTHMA MORBIDITY IN CHILDREN AS A RESULT OF HOME REMEDIATION AIMED AT MOISTURE SOURCES

    Science.gov (United States)

    Objective: Home dampness, presence of mold and allergens have been associated with asthma morbidity. We examined changes in asthma morbidity in children as a result of home remediation aimed at moisture sources.Design: Prospective, randomized controlled trial.Part...

  7. Process evaluation of a workplace health promotion intervention aimed at improving work engagement and energy balance

    NARCIS (Netherlands)

    Berkel, J. van; Boot, C.R.L.; Proper, K.I.; Bongers, P.M.; Beek, A.J. van der

    2013-01-01

    OBJECTIVE:: To evaluate the process of the implementation of an intervention aimed at improving work engagement and energy balance, and to explore associations between process measures and compliance. METHODS:: Process measures were assessed using a combination of quantitative and qualitative

  8. Process Evaluation of a Workplace Health Promotion Intervention Aimed at Improving Work Engagement and Energy Balance

    NARCIS (Netherlands)

    van Berkel, J.; Boot, C.R.L.; Proper, K.I.; Bongers, P.M.; van der Beek, A.J.

    2013-01-01

    OBJECTIVE:: To evaluate the process of the implementation of an intervention aimed at improving work engagement and energy balance, and to explore associations between process measures and compliance. METHODS:: Process measures were assessed using a combination of quantitative and qualitative

  9. Understanding and Improving the Assessment of Individual Motivation (AIM) in the Army's GED Plus Program

    National Research Council Canada - National Science Library

    Knapp, Deirdre

    2004-01-01

    .... Under this program, no%high school diploma graduates who might otherwise be ineligible for military service can enlist if they score sufficiently high on the AIM and meet other program requirements...

  10. Effects of anxiety on running with and without an aiming task.

    Science.gov (United States)

    Nibbeling, Nicky; Daanen, Hein A M; Gerritsma, Rens M; Hofland, Rianne M; Oudejans, Raôul R D

    2012-01-01

    State anxiety is known to affect far aiming tasks, but less is known about the effects of state anxiety on running and aiming while running. Therefore, in the current study participants ran on a treadmill at their preferred speed in a low- and high-anxiety condition. In both conditions, running was combined with dart throwing in the last minutes. Results showed that attention shifted away from task execution with elevated levels of anxiety. Furthermore, gait patterns were more conservative and oxygen uptake was higher with anxiety. In addition, performance and efficiency on the dart throwing task also decreased with anxiety. These findings are in line with attentional control theory and provide an indication that state anxiety not only affects aiming tasks but also tasks that rely heavily on the aerobic system. Moreover, findings indicate that when combined, running, aiming, and anxiety all compete for attention leading to suboptimal attentional control and possibly a decrease in performance.

  11. Advanced Integrated Multi-Sensor Surveillance (AIMS. Operator Machine Interface (OMI) Definition Study

    National Research Council Canada - National Science Library

    Baker, Kevin; Youngson, Gord

    2007-01-01

    To enhance the capability of airborne search and rescue (SAR) and surveillance, particularly at night and in poor weather, a multi sensor electro optical imaging system, the Advanced Integrated Multi sensor Surveillance (AIMS...

  12. Preparing the prescription: a review of the aim and measurement of social referral programmes.

    Science.gov (United States)

    Rempel, Emily S; Wilson, Emma N; Durrant, Hannah; Barnett, Julie

    2017-10-12

    Our aim is to review, and qualitatively evaluate, the aims and measures of social referral programmes. Our first objective is to identify the aims of social referral initiatives. Our second objective is to identify the measures used to evaluate whether the aims of social referral were met. Literature review. Social referral programmes, also called social prescribing and emergency case referral, link primary and secondary healthcare with community services, often under the guise of decreasing health system costs. Following the PRISMA guidelines, we undertook a literature review to address that aim. We searched in five academic online databases and in one online non-academic search engine, including both academic and grey literature, for articles referring to 'social prescribing' or 'community referral'. We identified 41 relevant articles and reports. After extracting the aims, measures and type of study, we found that most social referral programmes aimed to address a wide variety of system and individual health problems. This included cost savings, resource reallocation and improved mental, physical and social well-being. Across the 41 studies and reports, there were 154 different kinds of measures or methods of evaluation identified. Of these, the most commonly used individual measure was the Warwick-Edinburgh Mental Well-being Scale, used in nine studies and reports. These inconsistencies in aims and measures used pose serious problems when social prescribing and other referral programmes are often advertised as a solution to health services-budgeting constraints, as well as a range of chronic mental and physical health conditions. We recommend researchers and local community organisers alike to critically evaluate for whom, where and why their social referral programmes 'work'. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  13. Effects of Economic Policies Aimed at Encouraging a Healthier Grain Consumption

    OpenAIRE

    Nordstrom, Jonas; Thunstrom, Linda

    2007-01-01

    In this paper, we evaluate the effects of policy reforms aimed at achieving two policy objectives for grain consumption; (a) to double the intake of bread and breakfast cereals and (b) to ensure that half of the bread and breakfast cereals consumed are whole grain products. The overall aim of these policy objectives are to increase the dietary fibre intake from grain consumption so as to significantly contribute to the general recommended (minimum) increase of the fibre intake. Based on param...

  14. CoAIMs: a cost-effective panel of ancestry informative markers for determining continental origins.

    Directory of Open Access Journals (Sweden)

    Eric R Londin

    2010-10-01

    Full Text Available Genetic ancestry is known to impact outcomes of genotype-phenotype studies that are designed to identify risk for common diseases in human populations. Failure to control for population stratification due to genetic ancestry can significantly confound results of disease association studies. Moreover, ancestry is a critical factor in assessing lifetime risk of disease, and can play an important role in optimizing treatment. As modern medicine moves towards using personal genetic information for clinical applications, it is important to determine genetic ancestry in an accurate, cost-effective and efficient manner. Self-identified race is a common method used to track and control for population stratification; however, social constructs of race are not necessarily informative for genetic applications. The use of ancestry informative markers (AIMs is a more accurate method for determining genetic ancestry for the purposes of population stratification.Here we introduce a novel panel of 36 microsatellite (MSAT AIMs that determines continental admixture proportions. This panel, which we have named Continental Ancestry Informative Markers or CoAIMs, consists of MSAT AIMs that were chosen based upon their measure of genetic variance (F(st, allele frequencies and their suitability for efficient genotyping. Genotype analysis using CoAIMs along with a Bayesian clustering method (STRUCTURE is able to discern continental origins including Europe/Middle East (Caucasians, East Asia, Africa, Native America, and Oceania. In addition to determining continental ancestry for individuals without significant admixture, we applied CoAIMs to ascertain admixture proportions of individuals of self declared race.CoAIMs can be used to efficiently and effectively determine continental admixture proportions in a sample set. The CoAIMs panel is a valuable resource for genetic researchers performing case-control genetic association studies, as it can control for the

  15. Making the case for change: What researchers need to consider when designing behavior change interventions aimed at improving medication dispensing.

    Science.gov (United States)

    Cadogan, Cathal A; Ryan, Cristín; Hughes, Carmel

    2016-01-01

    There is a growing emphasis on behavior change in intervention development programmes aimed at improving public health and healthcare professionals' practice. A number of frameworks and methodological tools have been established to assist researchers in developing interventions seeking to change healthcare professionals' behaviors. The key features of behavior change intervention design involve specifying the target group (i.e. healthcare professional or patient cohort), the target behavior and identifying mediators (i.e. barriers and facilitators) of behavior change. Once the target behavior is clearly specified and understood, specific behavior change techniques can then be used as the basis of the intervention to target identified mediators of behavior change. This commentary outlines the challenges for pharmacy practice-based researchers in targeting dispensing as a behavior when developing behavior change interventions aimed at pharmacists and proposes a definition of dispensing to consider in future research. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity.

    Science.gov (United States)

    Man, Si Ming; Karki, Rajendra; Kanneganti, Thirumala-Devi

    2016-02-01

    Recognition of DNA by the cell is an important immunological signature that marks the initiation of an innate immune response. AIM2 is a cytoplasmic sensor that recognizes dsDNA of microbial or host origin. Upon binding to DNA, AIM2 assembles a multiprotein complex called the inflammasome, which drives pyroptosis and proteolytic cleavage of the proinflammatory cytokines pro-IL-1β and pro-IL-18. Release of microbial DNA into the cytoplasm during infection by Francisella, Listeria, Mycobacterium, mouse cytomegalovirus, vaccinia virus, Aspergillus, and Plasmodium species leads to activation of the AIM2 inflammasome. In contrast, inappropriate recognition of cytoplasmic self-DNA by AIM2 contributes to the development of psoriasis, dermatitis, arthritis, and other autoimmune and inflammatory diseases. Inflammasome-independent functions of AIM2 have also been described, including the regulation of the intestinal stem cell proliferation and the gut microbiota ecology in the control of colorectal cancer. In this review we provide an overview of the latest research on AIM2 inflammasome and its role in infection, cancer, and autoimmunity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model

    NARCIS (Netherlands)

    Silva-Santos, Sara; van Woerden, Geeske M.; Bruinsma, Caroline F.; Mientjes, Edwin; Jolfaei, Mehrnoush Aghadavoud; Distel, Ben; Kushner, Steven A.; Elgersma, Ype

    2015-01-01

    Angelman syndrome (AS) is a severe neurodevelopmental disorder that results from loss of function of the maternal ubiquitin protein ligase E3A (UBE3A) allele. Due to neuron-specific imprinting, the paternal UBE3A copy is silenced. Previous studies in murine models have demonstrated that strategies

  18. Qualitative approaches to use of the RE-AIM framework: rationale and methods.

    Science.gov (United States)

    Holtrop, Jodi Summers; Rabin, Borsika A; Glasgow, Russell E

    2018-03-13

    There have been over 430 publications using the RE-AIM model for planning and evaluation of health programs and policies, as well as numerous applications of the model in grant proposals and national programs. Full use of the model includes use of qualitative methods to understand why and how results were obtained on different RE-AIM dimensions, however, recent reviews have revealed that qualitative methods have been used infrequently. Having quantitative and qualitative methods and results iteratively inform each other should enhance understanding and lessons learned. Because there have been few published examples of qualitative approaches and methods using RE-AIM for planning or assessment and no guidance on how qualitative approaches can inform these processes, we provide guidance on qualitative methods to address the RE-AIM model and its various dimensions. The intended audience is researchers interested in applying RE-AIM or similar implementation models, but the methods discussed should also be relevant to those in community or clinical settings. We present directions for, examples of, and guidance on how qualitative methods can be used to address each of the five RE-AIM dimensions. Formative qualitative methods can be helpful in planning interventions and designing for dissemination. Summative qualitative methods are useful when used in an iterative, mixed methods approach for understanding how and why different patterns of results occur. In summary, qualitative and mixed methods approaches to RE-AIM help understand complex situations and results, why and how outcomes were obtained, and contextual factors not easily assessed using quantitative measures.

  19. Evaluation of an integrated adherence program aimed to increase Medicare Part D star rating measures.

    Science.gov (United States)

    Leslie, R Scott; Tirado, Breanne; Patel, Bimal V; Rein, Philip J

    2014-12-01

    of adherence and offer the members an option for monthly 30-day supply medication delivery via US MED. Member adherence rates were calculated 9 months pre- and postimplementation for all members and adjusted by length of member enrollment based on CMS technical specifications. Regression analysis assessed pre-post changes in rates comparing 2 intervention groups: (1) members receiving iCare counseling only (iCare-only) and (2) members receiving counseling and medication delivery (iCare + US MED). To evaluate the overall impact of the intervention, iCare's adherence rates and iCare's measure-specific star ratings for the 2011 and 2012 calendar years (CMS measurement years) were compared with the national MA-PD plan contract average and with a health plan similar in member characteristics but without adherence intervention exposure.  A total of 2,700 members were initially targeted for referral to iCare care management and US MED customer service specialist teams. Between April 2012 (implementation date) and January 2013, 1,302 (48.2%) members enrolled in the US MED component of the intervention. Seventy-six percent of identified members were nonadherent (PDC  less than  80%) to 1 of the 3 target medication classes, and 32% of members were nonadherent to more than 1 target medication class. Pre-post absolute average adherence rates increased for the iCare-only group (ODM = 15.1, HTN = 10.1, CHOL = 13.6) and the iCare-US MED group (ODM = 30.9, HTN = 25.5, CHOL = 29.4).  From 2011 to 2012, iCare adherence rates increased by absolute differences of 15.2, 9.2, and 10.1 percentage points for ODM, HTN, and CHOL measures, respectively, compared with the average MA-PD plan contract differences (1.1, 2.1, and 2.5) and the comparator health plan differences (-2.7, -1.4, and -4.1). Increases in iCare's adherence rates were associated with significant increases in iCare's 2014 adherence measure star ratings (1 star to 3 stars for ODM and CHOL, 1

  20. Absolute Radiometric Calibration of KOMPSAT-3A

    Directory of Open Access Journals (Sweden)

    H. Y. Ahn

    2016-06-01

    Full Text Available This paper presents a vicarious radiometric calibration of the Korea Multi-Purpose Satellite-3A (KOMPSAT-3A performed by the Korea Aerospace Research Institute (KARI and the Pukyong National University Remote Sensing Group (PKNU RSG in 2015.The primary stages of this study are summarized as follows: (1 A field campaign to determine radiometric calibrated target fields was undertaken in Mongolia and South Korea. Surface reflectance data obtained in the campaign were input to a radiative transfer code that predicted at-sensor radiance. Through this process, equations and parameters were derived for the KOMPSAT-3A sensor to enable the conversion of calibrated DN to physical units, such as at-sensor radiance or TOA reflectance. (2 To validate the absolute calibration coefficients for the KOMPSAT-3A sensor, we performed a radiometric validation with a comparison of KOMPSAT-3A and Landsat-8 TOA reflectance using one of the six PICS (Libya 4. Correlations between top-of-atmosphere (TOA radiances and the spectral band responses of the KOMPSAT-3A sensors at the Zuunmod, Mongolia and Goheung, South Korea sites were significant for multispectral bands. The average difference in TOA reflectance between KOMPSAT-3A and Landsat-8 image over the Libya 4, Libya site in the red-green-blue (RGB region was under 3%, whereas in the NIR band, the TOA reflectance of KOMPSAT-3A was lower than the that of Landsat-8 due to the difference in the band passes of two sensors. The KOMPSAT-3Aensor includes a band pass near 940 nm that can be strongly absorbed by water vapor and therefore displayed low reflectance. Toovercome this, we need to undertake a detailed analysis using rescale methods, such as the spectral bandwidth adjustment factor.

  1. Evaluation of measurement properties of self-administered PROMs aimed at patients with non-specific shoulder pain and "activity limitations": a systematic review.

    Science.gov (United States)

    Thoomes-de Graaf, M; Scholten-Peeters, G G M; Schellingerhout, J M; Bourne, A M; Buchbinder, R; Koehorst, M; Terwee, C B; Verhagen, A P

    2016-09-01

    To critically appraise and compare the measurement properties of self-administered patient-reported outcome measures (PROMs) focussing on the shoulder, assessing "activity limitations." Systematic review. The study population had to consist of patients with shoulder pain. We excluded postoperative patients or patients with generic diseases. The methodological quality of the selected studies and the results of the measurement properties were critically appraised and rated using the COSMIN checklist. Out of a total of 3427 unique hits, 31 articles, evaluating 7 different questionnaires, were included. The SPADI is the most frequently evaluated PROM and its measurement properties seem adequate apart from a lack of information regarding its measurement error and content validity. For English, Norwegian and Turkish users, we recommend to use the SPADI. Dutch users could use either the SDQ or the SST. In German, we recommend the DASH. In Tamil, Slovene, Spanish and the Danish languages, the evaluated PROMs were not yet of acceptable validity. None of these PROMs showed strong positive evidence for all measurement properties. We propose to develop a new shoulder PROM focused on activity limitations, taking new knowledge and techniques into account.

  2. Develop draft chip seal cover aggregate specification based on aggregate imaging system (AIMS) angularity, shape, and texture test results : final report.

    Science.gov (United States)

    2014-01-01

    The objective of the study is to improve Oklahoma Department of Transportation (ODOT) chip seal design and performance through introducing new criteria for the selection of cover aggregate and binder. The study evaluates the shape and texture-related...

  3. Consociation as a Nominal Retention Strategy: A Qualitative Case Study of a Specific Charter School and University College Partnership Aimed at Scholastic Impetus

    Science.gov (United States)

    Bailey, Jarvis

    2017-01-01

    This dissertation as an exploratory study examines the characteristics of the students of a charter school participating in a partnership with a university located in an improving low socioeconomic environment in the northeastern U.S., which has been dedicated to providing educational opportunities to the underserved. This dissertation also…

  4. The reliability of manual reporting of clinical events in an anesthesia information management system (AIMS).

    Science.gov (United States)

    Simpao, Allan F; Pruitt, Eric Y; Cook-Sather, Scott D; Gurnaney, Harshad G; Rehman, Mohamed A

    2012-12-01

    Manual incident reports significantly under-report adverse clinical events when compared with automated recordings of intraoperative data. Our goal was to determine the reliability of AIMS and CQI reports of adverse clinical events that had been witnessed and recorded by research assistants. The AIMS and CQI records of 995 patients aged 2-12 years were analyzed to determine if anesthesia providers had properly documented the emesis events that were observed and recorded by research assistants who were present in the operating room at the time of induction. Research assistants recorded eight cases of emesis during induction that were confirmed with the attending anesthesiologist at the time of induction. AIMS yielded a sensitivity of 38 % (95 % confidence interval [CI] 8.5-75.5 %), while the sensitivity of CQI reporting was 13 % (95 % CI 0.3-52.7 %). The low sensitivities of the AIMS and CQI reports suggest that user-reported AIMS and CQI data do not reliably include significant clinical events.

  5. Organizational technologies for transforming care: measures and strategies for pursuit of IOM quality aims.

    Science.gov (United States)

    Gamm, Larry; Kash, Bita; Bolin, Jane

    2007-01-01

    Progress on the Institute of Medicine's (IOM's) 6 aims to bridge the "quality chasm" requires both measurement and the concerting of multiple organizational technologies. The basic thesis of this article is that rapid progress on the IOM's multiple aims calls for transformative change within and among healthcare organizations. The promise of a number of types of transformative approaches is closely linked to their ability to simultaneously build upon several organizational technologies: clinical, social, information, and administrative technologies. To encourage and advance such efforts, this article identifies illustrative measures of attainment of the IOM's 6 aims or targeted areas for improvement that reflect the contributions of the 4 organizational technologies. It discusses examples of relationships between the IOM aims and the organizational technologies considered. Finally, the article offers illustrations of the interplay of these organizational technologies and IOM aims-across an array of organizational innovations with transformative potential. Included among such innovations are information technology in the form of electronic medical records, computer-based physician order entry, and patient health records; organization-wide patient-centered cultural change such as Studer's Hardwiring Excellence; Six Sigma and Toyota Production Management/LEAN; major clinical technology change, for example, minimally invasive cardiac surgery and broader treatment innovations such as disease management.

  6. The alcohol industry's way to discipline pleasure. Prevention campaigns aimed at Danish youth

    DEFF Research Database (Denmark)

    Demant, Jakob Johan; Houborg, Esben

    2011-01-01

    people. Both campaigns aim to associate alcohol consumption with a disciplined pleasure that does not involve intoxication. In this way alcohol policy becomes a politics of pleasure. Conclusion – Alcohol prevention that aims to moderate alcohol consumption among young people by associating alcohol......Aims – To analyze how two youth alcohol prevention campaigns funded by the Danish alcohol industry articulate the relationship between alcohol, intoxication and pleasure. Design – The two campaigns are first analyzed by applying an analytical model developed by Karlsson and Bergmark (2009......) to analyze drug prevention campaigns in Sweden. After this a more detailed analysis of how the two campaigns articulate pleasure is done. Results – Both campaigns recognize recreational motives for consuming alcohol. In both campaigns pleasure is central to the regulation of alcohol consumption among young...

  7. Telehealth and Occupational Therapy: Integral to the Triple Aim of Health Care Reform.

    Science.gov (United States)

    Cason, Jana

    2015-01-01

    Programs and concepts included in the Patient Protection and Affordable Care Act of 2010 are expected to transform health care in the United States from a volume-based health system to a value-based health system with increased emphasis on prevention and health promotion. The Triple Aim, a framework set forth by the Institute for Healthcare Improvement, focuses on improving the health care experience, the health of populations, and the affordability of care. This article describes telehealth as an integral component in achieving the Triple Aim of health care and discusses implications for occupational therapy practitioners. Copyright © 2015 by the American Occupational Therapy Association, Inc.

  8. Savannah River Plant's Accountability Inventory Management System (AIMS) (Nuclear materials inventory control)

    International Nuclear Information System (INIS)

    Croom, R.G.

    1976-06-01

    The Accountability Inventory Management System (AIMS) is a new computer inventory control system for nuclear materials at the Savannah River Plant, Aiken, South Carolina. The system has two major components, inventory files and system parameter files. AIMS, part of the overall safeguards program, maintains an up-to-date record of nuclear material by location, produces reports required by ERDA in addition to onplant reports, and is capable of a wide range of response to changing input/output requirements through use of user-prepared parameter cards, as opposed to basic system reprogramming

  9. Using the RE-AIM Framework to Evaluate Disaster Recovery Videos

    Directory of Open Access Journals (Sweden)

    Sarah Cronin

    2018-02-01

    Full Text Available Natural disasters both increase and cause financial challenges for survivors. Crisis support reduces negative outcomes such as financial stress, yet survivors are often unaware or unable to access available services. Aiming to innovatively improve access to quality financial education and to support financial recovery post-disaster, a video series was developed with a community advisory board. The RE-AIM framework informed a developmental evaluation measuring the videos’ influence. Results indicated majority of participants have used or intend to use the videos in their disaster work. This indicates the video series may be a helpful tool for disaster responders when providing financial recovery support.

  10. Bio-AIMS Collection of Chemoinformatics Web Tools based on Molecular Graph Information and Artificial Intelligence Models.

    Science.gov (United States)

    Munteanu, Cristian R; Gonzalez-Diaz, Humberto; Garcia, Rafael; Loza, Mabel; Pazos, Alejandro

    2015-01-01

    The molecular information encoding into molecular descriptors is the first step into in silico Chemoinformatics methods in Drug Design. The Machine Learning methods are a complex solution to find prediction models for specific biological properties of molecules. These models connect the molecular structure information such as atom connectivity (molecular graphs) or physical-chemical properties of an atom/group of atoms to the molecular activity (Quantitative Structure - Activity Relationship, QSAR). Due to the complexity of the proteins, the prediction of their activity is a complicated task and the interpretation of the models is more difficult. The current review presents a series of 11 prediction models for proteins, implemented as free Web tools on an Artificial Intelligence Model Server in Biosciences, Bio-AIMS (http://bio-aims.udc.es/TargetPred.php). Six tools predict protein activity, two models evaluate drug - protein target interactions and the other three calculate protein - protein interactions. The input information is based on the protein 3D structure for nine models, 1D peptide amino acid sequence for three tools and drug SMILES formulas for two servers. The molecular graph descriptor-based Machine Learning models could be useful tools for in silico screening of new peptides/proteins as future drug targets for specific treatments.

  11. Assess, Identify, Make it Happen (AIM) for Preschools: A Tool to Decrease Early Childhood Obesity.

    Science.gov (United States)

    Farewell, Charlotte V; Puma, Jini E; Powers, Jamie; Belansky, Elaine S

    2017-12-01

    Early childhood obesity is at epidemic proportions and is a major risk factor for the development of chronic diseases in adulthood. Since the majority of preschoolers are placed in center-based care, best practice policy, system, and environment (PSE) changes in early child care settings plays an important role in defining early development of obesogenic behaviors. However, implementation of best practice PSE changes is often a challenge in low resource settings due to staff turnover, time constraints, cultural beliefs, and lack of health-related knowledge. Assess, Identify, Make it Happen for Preschools (AIM-P) is a strategic planning process that was used with wellness teams in early child care centers to implement PSE changes that support adoption of health behaviors. AIM-P uses key change-making strategies based on intervention mapping including assets and needs assessments, prioritization of changes based on importance and feasibility, development of action steps and action plans, and identification of dissemination and sustainability plans. The AIM-P process resulted in implementation of 6.5 best practice PSE changes per site. Qualitative findings highlight lessons learned and the facilitators and barriers associated with using AIM-P to implement PSEs.

  12. Theory of Knowledge Aims, Objectives and Assessment Criteria: An Analysis of Critical Thinking Descriptors

    Science.gov (United States)

    Hughes, Conrad

    2014-01-01

    This article analyses the construct validity of the International Baccalaureate Diploma Programme's Theory of Knowledge course in the light of claims that it is a course in critical thinking. After discussion around critical thinking--what it is and why it is valuable educationally--the article analyses the extent to which the course aims,…

  13. The EU-AIMS Longitudinal European Autism Project (LEAP) : Clinical characterisation

    NARCIS (Netherlands)

    Charman, Tony; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, Caroline; Goyard, David; Ahmad, Jumana; Auyeung, Bonnie; Ambrosino, Sara; Banaschewski, Tobias; Baron-Cohen, Simon; Baumeister, Sarah; Beckmann, Christian; Bölte, Sven; Bourgeron, Thomas; Bours, Carsten; Brammer, Michael; Brandeis, Daniel; Brogna, Claudia; De Bruijn, Yvette; Chakrabarti, Bhismadev; Cornelissen, Ineke; Acqua, Flavio Dell; Dumas, Guillaume; Durston, Sarah; Ecker, Christine; Faulkner, Jessica; Frouin, Vincent; Garcés, Pilar; Ham, Lindsay; Hayward, Hannah; Hipp, Joerg; Holt, Rosemary J.; Isaksson, Johan; Johnson, Mark H.; Jones, Emily J.H.; Kundu, Prantik; Lai, Meng Chuan; D'Ardhuy, Xavier Liogier; Lombardo, Michael V.; Lythgoe, David J; Mandl, René; Mason, Luke; Meyer-Lindenberg, Andreas; Moessnang, Carolin; Mueller, Nico; O'Dwyer, Laurence; Oldehinkel, Marianne; Oranje, Bob; Pandina, Gahan; Persico, Antonio M.; Ruggeri, Barbara; Ruigrok, Amber N V; Sabet, Jessica; Sacco, Roberto; Cáceres, Antonia San Jóse; Simonoff, Emily; Toro, Roberto; Tost, Heike; Waldman, Jack; Williams, Steve C.R.; Zwiers, Marcel P.; Spooren, Will; Murphy, Declan G M; Buitelaar, Jan K.

    2017-01-01

    Background: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ

  14. Appeals in television advertising. A content analysis of commercials aimed at children and teenagers

    NARCIS (Netherlands)

    Buijzen, M.A.; Valkenburg, P.M.

    2002-01-01

    A content analysis of 601 commercials was conducted in order to identify the appeals that characterize commercials aimed at children and teenagers. Our findings demonstrated that the use of appeals (a) showed strong age differences and (b) was highly gender-role stereotyped, particularly in

  15. AN ADAPTIVE ACO-DRIVEN SCHEME FOR LEARNING AIM ORIENTED PERSONALIZED E-LEARNING

    Directory of Open Access Journals (Sweden)

    Sushma Hans

    2014-10-01

    Full Text Available The e-learning paradigm is now a well-established vehicle of modern education. It caters to a wide spectrum of students with diverse backgrounds who enroll with their own learning aims. A core challenge under this scenario is to generate personalized learning paths so that each student can achieve her learning aim most effectively. Prior works used static attributes such as prior knowledge level, learning ability, browsing preferences, learning style etc. to generate personalized learning paths. In this paper, we take an entirely new route by taking into account the continuous improvement of a learner in the light of her own learning aim, to redefine her learning path at each level of the course. We introduce the concept of personalized examination system that systematically evaluates the dynamic learning ability of every student according to her pre-set goals. The proposed intelligent e-learning system uses Ant Colony Optimization to iteratively optimize the forward learning paths. Experimental results reveal that the system is able to tap a student’s improved learning ability to choose more difficult paths that contribute highly towards her own aims. We demonstrate that the overall learning success of weaker students doubles as compared to statically generated paths while there is considerable improvement of 50% in the learning success for average students as well. This clearly indicates that our approach gives realistic benefits to initially weak students who gradually evolve as the course progresses.

  16. Applying Athletic Identify Measurement Scale on Physical Educators: Turkish Version of AIMS

    Science.gov (United States)

    Tunçkol, H. Mehmet

    2015-01-01

    In sports research, defining athletic identity of individuals is an important study subject. The subject owes its significance to the fact that an individual's athletic identity affects his other identities throughout his life span. The aim of this study is to test the reliability and validity of the Turkish version of Athletic Identity…

  17. [Intercultural adaptation of the AIMS in German language: A scale for abnormal involuntary movements].

    Science.gov (United States)

    Buhmann, C; Rizos, A; Emmans, D; Jost, W H

    2016-04-01

    Dyskinesias are abnormal involuntary movements and occur across many movement disorders. In Parkinson's disease dyskinesias can be troublesome and are a determinant of the quality of life throughout the course of the disease. Assessment and rating of dyskinesias is thus important for clinical assessment of patients, as well as for academic studies and clinical trials. The abnormal involuntary movement scale (AIMS) is an English language standardised, reliable and validated scale to evaluate dyskinesias. In this article we present a linguistically validated German version of AIMS. The intercultural adaptation of the German translation was performed following an internationally accepted procedure. Firstly, two neurologists independently translated the original into German. Taking both versions into account, a consensus version was agreed on by both translators and was tested on 10 patients. This preliminary German version was then independently translated back into the original language by two different neurologists, and again, a consensus version was agreed on. All translators then compared this English version to the original. Subsequently, the German version was linguistically modified until it resulted in a final German version, which was agreed on by all translators, deemed linguistically acceptable, and the translation back into English was considered to be as unambiguous as possible. This final German version of AIMS was applied to 50 patients in two different hospitals for diagnostic purposes and tested for feasibility and comprehension. In this paper, we present an intercultural adaptation of a linguistically validated German version of AIMS.

  18. Where are we now? The strengthened safeguards system: Origins, aims, features, issues and prospects

    International Nuclear Information System (INIS)

    Schriefer, D.

    1998-01-01

    The present status of the strengthened safeguards system includes the origins, aims, features, issues and future prospects. The areas of emphasis concerning the strengthened safeguards system are: access to information (environmental sampling and improved information analysis), access to sites, rational use of resources (cost analysis of present safeguards, increased cooperation with state systems, cost savings in traditional safeguards activities)

  19. Interpretive Research Aiming at Theory Building: Adopting and Adapting the Case Study Design

    Science.gov (United States)

    Diaz Andrade, Antonio

    2009-01-01

    Although the advantages of case study design are widely recognised, its original positivist underlying assumptions may mislead interpretive researchers aiming at theory building. The paper discusses the limitations of the case study design for theory building and explains how grounded theory systemic process adds to the case study design. The…

  20. Process Evaluation of an Occupational Health Guideline Aimed at Preventing Weight Gain Among Employees

    NARCIS (Netherlands)

    Verweij, Lisanne M.; Proper, Karin I.; Hulshof, Carel T. J.; van Mechelen, Willem

    2011-01-01

    Objective: To evuate the process of an occupational health guideline aimed at preventing weight gain. Methods: Quantitative data on seven process items were assessed and linked to effects on employees' waist circumference and body weight at 6 months. Results: Occupational physicians (n = 7)

  1. Sustainability with an Ethical Aim: Lessons from an American Nun in Amazonia

    Science.gov (United States)

    Demaree, Stephanie

    2012-01-01

    Research Topic: An exploration into human imagination, ethical aim and action are the progenitors for reconciliation between humans and their environment. This study of two successful projects in Brazil provides an example of working toward a balance between human endeavors and sustainable environments. This inquiry is an exploration that…

  2. Empowering employees with chronic diseases : process evaluation of an intervention aimed at job retention

    NARCIS (Netherlands)

    Varekamp, Inge; Krol, Boudien; van Dijk, Frank J. H.

    Purpose Employees with a chronic disease may experience work-related problems that contribute to the risk of job loss. We developed a group-based intervention programme aimed at clarifying problems, making these a subject of discussion at work, and realizing solutions. This process evaluation

  3. Empowering employees with chronic diseases: process evaluation of an intervention aimed at job retention

    NARCIS (Netherlands)

    Varekamp, Inge; Krol, Boudien; van Dijk, Frank J. H.

    2011-01-01

    Purpose Employees with a chronic disease may experience work-related problems that contribute to the risk of job loss. We developed a group-based intervention programme aimed at clarifying problems, making these a subject of discussion at work, and realizing solutions. This process evaluation

  4. Bader's Theory of Atoms in Molecules (AIM) and its Applications to ...

    Indian Academy of Sciences (India)

    Bader's Theory of Atoms in Molecules (AIM) and its Applications to Chemical Bonding. P SHYAM VINOD KUMAR, V RAGHAVENDRA and V SUBRAMANIAN. ∗. Chemical ... QTAIM; non-covalent interaction; chemical bonding; H-bonding; electron density. 1. ... the volume element of the system under consideration. The ED ...

  5. What Should We Share? : Understanding the Aim of Intercultural Information Ethics

    NARCIS (Netherlands)

    Wong, Pak-Hang

    2009-01-01

    The aim of Intercultural Information Ethics (IIE), as Ess aptly puts, is to “(a) address both local and global issues evoked by ICTs / CMC, etc., (b) in a ways that both sustain local traditions / values / preference, etc. and (c) provide shared, (quasi-) universal responses to central ethical

  6. RE-AIM Checklist for Integrating and Sustaining Tier 2 Social-Behavioral Interventions

    Science.gov (United States)

    Cheney, Douglas A.; Yong, Minglee

    2014-01-01

    Even though evidence-based Tier 2 programs are now more commonly available, integrating and sustaining these interventions in schools remain challenging. RE-AIM, which stands for Reach, Effectiveness, Adoption, Implementation, and Maintenance, is a public health framework used to maximize the effectiveness of health promotion programs in…

  7. Yoruba Deities In Aimé Césaire\\'s Dramaturgy | Arowolo | Journal of ...

    African Journals Online (AJOL)

    The French Caribbean Literature is replete with African cultural archetypes, an important inheritance from the African origin of the predominantly black population. Most prominent of these archetypes are traceable to the Yoruba culture and faith system. This paper studies the esthetic use of Yoruba deities in Aimé Césaire\\'s ...

  8. Aiming at a far target under different viewing conditions: Visual control in basketball jump shooting

    NARCIS (Netherlands)

    Oudejans, R.R.D.; van de Langenberg, R.W.; Hutter, R.I.

    2002-01-01

    Most research on visual search in aiming at far targets assumes preprogrammed motor control implying that relevant visual information is detected prior to the final shooting or throwing movements. Eye movement data indirectly support this claim for stationary tasks. Using the basketball jump shot as

  9. High quality data: An evaluation of AIM data quality and data quality procedures

    Science.gov (United States)

    The goal of every monitoring program is to collect high-quality data which can then be used to provide information to decision makers. The Bureau of Land Management (BLM) Assessment, Inventory, and Monitoring (AIM) program is one such data set which provides rangeland status, condition, and trend in...

  10. Evaluation of methods aimed at complete removal of template from molecularly imprinted polymers

    NARCIS (Netherlands)

    Ellwanger, A; Berggren, C; Bayoudh, S; Crecenzi, C; Karlsson, L; Owens, PK; Ensing, K; Cormack, P; Sherrington, D; Sellergren, B

    2001-01-01

    Polymers imprinted with clenbuterol were used to study the influence of various post-polymerization treatments [e.g., thermal annealing, microwave assisted extraction (MAE), Soxhlet extraction and supercritical fluid template desorption] on the bleeding of residual template. The aim of the study was

  11. Alginate Immobilization of Metabolic Enzymes (AIME) for High-Throughput Screening Assays (SOT)

    Science.gov (United States)

    Alginate Immobilization of Metabolic Enzymes (AIME) for High-Throughput Screening Assays DE DeGroot, RS Thomas, and SO SimmonsNational Center for Computational Toxicology, US EPA, Research Triangle Park, NC USAThe EPA’s ToxCast program utilizes a wide variety of high-throughput s...

  12. Francis Moto The aim of this paper is to describe tonal mobility in ...

    African Journals Online (AJOL)

    Francis Moto. The aim of this paper is to describe tonal mobility in. Chichewa. We will establish that the surface positions of. Chichewa tonal contrasts do not always con-espond to their original locations in the underlying structure, but rather that their point of origin may be in preceding syllables, morphemes or even words, ...

  13. Aiming and clicking in young children's use of the computer mouse

    NARCIS (Netherlands)

    Donker, A.; Reitsma, P.

    2007-01-01

    The present study investigated the abilities of young children to aim and click with a computer mouse. Young children have not yet fully developed their motor skills and they are therefore more likely than adults to click next to targets on the computer screen. Because in educational software

  14. Factors influencing the design of aiming devices for intraoral radiography and their practical application

    NARCIS (Netherlands)

    Aken, J. van; Verhoeven, J.W.

    Intraoral roentgenograms can be made according to the long-tube paralleling technique utilizing aiming devices. These instruments consist of a bite block, an indicator rod, and a collimator plate. For the position of the film in relation to the bite block surface, the following data are decisive and

  15. Early parenting intervention aimed at maternal sensitivity and discipline: A process evaluation

    NARCIS (Netherlands)

    Stolk, M.N.; Mesman, J.; van Zeijl, J.; Alink, L.R.A.; Bakermans-Kranenburg, M.J.; van IJzendoorn, M.H.; Juffer, F.; Koot, H.M.

    2008-01-01

    This study investigated the influence of the intervention process on the effectiveness of a program aimed at promoting positive parenting. The study involved a homogeneous intervention sample (N = 120) of mothers and their 1-, 2-, or 3-year-old children screened for high levels of externalizing

  16. Evaluation of a School-Based Program Aimed at Preventing Depressive Symptoms in Adolescents

    Science.gov (United States)

    Garmy, Pernilla; Jakobsson, Ulf; Carlsson, Katarina Steen; Berg, Agneta; Clausson, Eva K.

    2015-01-01

    The aim of this pilot study was to evaluate the implementation of a universal school-based cognitive behavioral program whose target is to prevent depressive symptoms in adolescents. The study had a quasi-experimental design with pretest, posttest, and a 1-year follow-up and provides an illustrative calculation for the implementation costs of the…

  17. Advanced Industrial Materials (AIM) Program: Compilation of project summaries and significant accomplishments, FY 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    In many ways, the Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven ``Vision Industries`` that use about 80% of industrial energy and generated about 90% of industrial wastes. The mission of AIM has, therefore, changed to ``Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.`` Though AIM remains essentially a National Laboratory Program, it is essential that each project have industrial partners, including suppliers to, and customers of, the seven industries. Now, well into FY 1996, the transition is nearly complete and the AIM Program remains reasonably healthy and productive, thanks to the superb investigators and Laboratory Program Managers. This report contains the technical details of some very remarkable work by the best materials scientists and engineers in the world. Subject areas covered are: advanced metals and composites; advanced ceramics and composites; polymers and biobased materials; and new materials and processes.

  18. The multinational birth cohort of EuroPrevall: background, aims and methods

    NARCIS (Netherlands)

    Keil, T.; McBride, D.; Grimshaw, K.; Niggemann, B.; Xepapadaki, P.; Zannikos, K.; Sigurdardottir, S. T.; Clausen, M.; Reche, M.; Pascual, C.; Stanczyk, A. P.; Kowalski, M. L.; Dubakiene, R.; Drasutiene, G.; Roberts, G.; Schoemaker, A.-F. A.; Sprikkelman, A. B.; Fiocchi, A.; Martelli, A.; Dufour, S.; Hourihane, J.; Kulig, M.; Wjst, M.; Yazdanbakhsh, M.; Szépfalusi, Z.; van Ree, R.; Willich, S. N.; Wahn, U.; Mills, E. N. C.; Beyer, K.

    2010-01-01

    P>Background/aim: The true prevalence and risk factors of food allergies in children are not known because estimates were based predominantly on subjective assessments and skin or serum tests of allergic sensitization to food. The diagnostic gold standard, a double-blind placebo-controlled food

  19. Unwanted effects in aiming actions: The relationship between gaze behavior and performance in golf putting task

    NARCIS (Netherlands)

    Binsch, O.; Oudejans, R.R.D.; Bakker, F.C.; Savelsbergh, G.J.P.

    2009-01-01

    Objectives: Instructions to avoid an action may increase the tendency to engage in the action (ironic effects) or cause an undesirable increase in the opposing action (overcompensation). The aim of the study was to examine the relationship between gaze behavior and performance in a golf putting task

  20. Effects of an intervention aimed at improving nurse-patient communication in an oncology outpatient clinic

    DEFF Research Database (Denmark)

    Rask, Mette Trøllund; Jensen, Mette Lund; Andersen, Jørn

    2009-01-01

    In an ever more burdened healthcare system, there is an urgent need to investigate whether patients benefit from the resources allocated to nurses' communication skills training in terms of improved patient outcomes. This study aimed to evaluate a standardized two 2-day (33 hours) communication s...

  1. Integrated assessment of biodiesel policies aimed at family farms in Brazil

    NARCIS (Netherlands)

    Belo Leite, Dal J.G.; Nunes Vieira da Silva, J.V.; Ittersum, van M.K.

    2014-01-01

    With many of the poor people in Brazil living in rural areas, local governments have intensified their efforts to design and implement effective policies that boost rural development. In 2004, a national program for production and use of biodiesel was launched aiming at increasing income among less

  2. Process evaluation of a web-based intervention aimed at empowerment of disability benefit claimants

    NARCIS (Netherlands)

    Samoocha, D.; Snels, I.A.K.; Bruinvels, D.J.; Anema, J.R.; Kowalczyk, W.J.; van der Beek, A.J.

    2011-01-01

    Background: The objective of this process evaluation study was to gain insight into the reach, compliance, appreciation, usage barriers, and users' perceived effectiveness of a web-based intervention http://www.wiagesprek.nl. This intervention was aimed at empowerment of disability claimants, prior

  3. Process evaluation of a web-based intervention aimed at empowerment of disability benefit claimants

    NARCIS (Netherlands)

    Samoocha, David; Snels, Ingrid A. K.; Bruinvels, David J.; Anema, Johannes R.; Kowalczyk, Wojtek; van der Beek, Allard J.

    2011-01-01

    The objective of this process evaluation study was to gain insight into the reach, compliance, appreciation, usage barriers, and users' perceived effectiveness of a web-based intervention http://www.wiagesprek.nl. This intervention was aimed at empowerment of disability claimants, prior to the

  4. Listen, live and learn: A review of the application process, aiming to ...

    African Journals Online (AJOL)

    The Listen, Live and Learn (LLL) initiative at Stellenbosch University (SU) is a senior student housing model with the aim of providing an experiential opportunity for students to make contact with 'the other'. It is posited on the social contact theory assumption that if people of different genders, races, ethnicities, and/or ...

  5. Effects of an inconsistency-detection training aimed at improving comprehension monitoring in primary school children

    NARCIS (Netherlands)

    Wassenburg, S.I.; Bos, L.T.; de Koning, B.B.; van der Schoot, M.

    2015-01-01

    Grounded within the situation model framework, this study investigated the effectiveness of a reading comprehension strategy training aimed at improving children’s comprehension monitoring strategies. Sixty-four third and fourth graders received a 4-week training targeted at situation model

  6. An Index (PC) Aimed at Monitoring the (P)olar (C)ap for Magnetic Activity

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — PC is an index for magnetic activity in the (P)olar (C)ap. It is based on data from a single nearpole station, and aimed to monitor the polar cap magnetic activity...

  7. InnoDemo Survey Report: Aims and results of demonstration projects in renewable energy and transport

    OpenAIRE

    Olsen, Dorothy Sutherland

    2014-01-01

    This report summarises the findings of a survey of demonstration projects related to energy and transport. The survey was designed to develop an overview of the aims of these projects and the results they have achieved. The projects were carried out in Norway, Sweden and Denmark in the period between 2002 and 2012 and all of them received public funding.

  8. Development Principles of the Pedagogical System Aimed at Bachelor Training Based on Modern Information Technology

    Science.gov (United States)

    Kurymbayev, Sayat G.; Samashova, Gulfarida E.; Alshynbayeva, Zhuldyz E.; Mukhametzhanova, Aigul O.; Sharazdin, Adilzada M.; Kalybekova, Kalamkas S.; Kosybaeva, Umitzhan A.

    2016-01-01

    Modern education is aimed at training competent specialists, which requires modernizing the training process by implementing innovative technologies, especially information technologies. Information technologies allow quickly accessing necessary data, which speeds up the training process. This paper deals with issues related to training bachelors…

  9. SYNTHESIS OF NEURAL NETWORK MODEL REFERENCE CONTROLLER FOR AIMING AND STABILIZING SYSTEM

    Directory of Open Access Journals (Sweden)

    B.I. Kuznetsov

    2015-11-01

    Full Text Available The aim of this work is the synthesis of neural network reference model controller. The synthesis is performed in MATLAB for the problem of control of the aiming and stabilization system for the special equipment of moving objects. This paper presents the synthesis of the neural network reference model controller to meet the given performance characteristics of operation for the aiming and stabilization system for the special equipment of moving objects. Simulink tool in MATLAB is used to build the block diagram of double-loop neural network system of aiming and stabilization, where the reference model controller is put in the velocity loop and P-regulator is put in the position loop, with feedforward velocity control. Presented the method of synthesis of the neural network reference model controller that is implemented in the Neural Network Toolbox in MATLAB. System tests with the broad range of parameter values determined the key parameters defining the control quality. Optimal values of the key parameters were found to provide the highest control performance. System simulation and analysis of the obtained results is given.

  10. Extending Energy Optimization in Goal-Directed Aiming from Movement Kinematics to Joint Angles

    NARCIS (Netherlands)

    Burkitt, James J.; Bongers, Raoul M.; Elliott, Digby; Hansen, Steve; Lyons, James L.

    2017-01-01

    Energy optimization in goal-directed aiming has been demonstrated as an undershoot bias in primary movement endpoint locations, especially in conditions where corrections to target overshoots must be made against gravity. Two-component models of upper limb movement have not yet considered how joint

  11. A Policy Framework for Health Systems to Promote Triple Aim Innovation.

    Science.gov (United States)

    Verma, Amol; Bhatia, Sacha

    2016-01-01

    With the expiry of the Health Accords, provincial governments must face the challenge of improving performance in the context of ageing demographics, increasing multi-morbidity, and real concerns about financial stability. The Institute for Healthcare Improvement Triple Aim articulates fundamental goals that can guide health system transformation: improved population health, enhanced patient experience and reduced or stable per capita costs. Advancing fragmented and costly health systems in pursuit of these goals requires transformative, as opposed to iterative, change. Provincial governments are ideally suited to lead this change by acting as "integrators" who link healthcare organizations and align incentives across the spectrum of delivery. Although there is very limited evidence regarding the effectiveness of system-level reforms, we draw on initiatives from around the world to suggest policies that can promote system-level Triple Aim innovation. We categorize these policies within the classic functions ascribed to health systems: financing, stewardship and resource generation. As healthcare financers, governments should orient procurement policy towards the Triple Aim innovation and reform payment to reward value not volume. As health system stewards, governments should define a Triple Aim vision; measure and report outcomes, patient experience, and costs; integrate across sectors; and facilitate learning from failure and spread of successful innovation. As resource generators, governments should invest in health information technology to exploit "big data" and ensure that professional education equips front-line clinicians with skills necessary to improve systems. There are a number of barriers to system-level Triple Aim innovation. There is a lack of evidence for macro-level policy changes, innovation is costly and complicated, and system reform may not be politically appealing. Triple Aim innovation may also be conflated with organization-level quality

  12. The orientation, principles, priorities and aims of the state environmental policy

    International Nuclear Information System (INIS)

    1998-01-01

    This chapter contains: (A) The orientation and priorities of state environmental policy of the government of the Slovak Republic which were approved 18 November 1993 by the resolution No 339. On the basis of the Strategy, principles and priorities of state environmental policy 70 short-terminable aims up to 1996, next 59 middle-terminable of aims up to years 2000 - 2010 and 33 general and partial long-terminable aims up to 2030 and longer were formulated. The Strategy is determined by next 5 branches oriented priorities: (1) air protection before pollutants and the global environmental safety; (2) organization of sufficiency of drinking water and decreasing of pollution of other waters under permissible limits; (3) soil protection before degeneration and organization of non-defected food-stuffs and other wares; (4) minimization of formation, use and good waste liquidate; (5) preservation of bio-diversity, preservation and rational use of natural reserves and optimization of place structure and use of the country. (B) The principles and priorities of state environmental policy determinate implementation and observance of then principles of the state environmental policy. (C) Total 162 aims of the Strategy of the state environmental policy and next followed programs, projects and measures of the environmental policy of the Slovak Republic can be grouped into 4 blocks: (1) the environmental policy in the protection of air, water and before of risk factors, in the nuclear safety and waste economy (environmental safety; (2) the environmental policy in protection of the nature and the country, protection and use of mineral surroundings, soils and forest;; (3) the environmental policy in the economy; (4) the environmental policy in the guidance, education, public information, organization, control and coordination of the ministration on the environment. These aims are grouped into 10 sectors. (D) The government of the Slovak republic has first National environmental

  13. MB3a Infrasound Sensor Evaluation.

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion J.; McDowell, Kyle D.

    2014-11-01

    Sandia National Laboratories has tested and evaluated a new infrasound sensor, the MB3a, manufactured by Seismo Wave. These infrasound sensors measure pressure output by a methodology developed by researchers at the French Alternative Energies and Atomic Energy Commission (CEA) and the technology was recently licensed to Seismo Wave for production and sales. The purpose of the infrasound sensor evaluation was to determine a measured sensitivity, transfer function, power, self-noise, dynamic range, seismic sensitivity, and self- calibration ability. The MB3a infrasound sensors are being evaluated for potential use in the International Monitoring System (IMS) of the Comprehensive Nuclear Test-Ban-Treaty Organization (CTBTO).

  14. Aiming for a simpler early arthritis MRI protocol: can Gd contrast administration be eliminated?

    International Nuclear Information System (INIS)

    Stomp, Wouter; Bloem, Johan L.; Reijnierse, Monique; Krabben, Annemarie; Heijde, Desiree van der; Huizinga, Tom W.J.; Helm-van Mil, Annette H.M. van der; Oestergaard, Mikkel

    2015-01-01

    To evaluate whether intravenous gadolinium (Gd) contrast administration can be eliminated when evaluating synovitis and tenosynovitis in early arthritis patients, thereby decreasing imaging time, cost, and invasiveness. Wrist MRIs of 93 early arthritis patients were evaluated by two readers for synovitis of the radioulnar, radiocarpal, and intercarpal joints, according to the Rheumatoid Arthritis MRI Scoring method (RAMRIS), and for tenosynovitis in ten compartments. Scores of MRI images without Gd contrast enhancement were compared to scores obtained when evaluating all, including contrast-enhanced, MRI images as reference. Subsequently, a literature review and pooled analysis of data from the present and two previous studies were performed. At the individual joint/tendon level, sensitivity to detect synovitis without Gd contrast was 91 % and 72 % for the two readers, respectively, with a specificity of 51 % and 81 %. For tenosynovitis, the sensitivity was 67 % and 54 %, respectively, with a specificity of 87 % and 91 %. Pooled data analysis revealed an overall sensitivity of 81 % and specificity of 50 % for evaluation of synovitis. Variations in tenosynovitis scoring systems hindered pooled analyses. Eliminating Gd contrast administration resulted in low specificity for synovitis and low sensitivity for tenosynovitis, indicating that Gd contrast administration remains essential for an optimal assessment. (orig.)

  15. Aiming for a simpler early arthritis MRI protocol: can Gd contrast administration be eliminated?

    Energy Technology Data Exchange (ETDEWEB)

    Stomp, Wouter; Bloem, Johan L.; Reijnierse, Monique [Leiden University Medical Center, Department of Radiology, P.O. Box 9600, Leiden (Netherlands); Krabben, Annemarie; Heijde, Desiree van der; Huizinga, Tom W.J.; Helm-van Mil, Annette H.M. van der [Leiden University Medical Center, Department of Rheumatology, P.O. Box 9600, Leiden (Netherlands); Oestergaard, Mikkel [University of Copenhagen, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spinal Diseases, Glostrup Hospital, Glostrup (Denmark)

    2015-05-01

    To evaluate whether intravenous gadolinium (Gd) contrast administration can be eliminated when evaluating synovitis and tenosynovitis in early arthritis patients, thereby decreasing imaging time, cost, and invasiveness. Wrist MRIs of 93 early arthritis patients were evaluated by two readers for synovitis of the radioulnar, radiocarpal, and intercarpal joints, according to the Rheumatoid Arthritis MRI Scoring method (RAMRIS), and for tenosynovitis in ten compartments. Scores of MRI images without Gd contrast enhancement were compared to scores obtained when evaluating all, including contrast-enhanced, MRI images as reference. Subsequently, a literature review and pooled analysis of data from the present and two previous studies were performed. At the individual joint/tendon level, sensitivity to detect synovitis without Gd contrast was 91 % and 72 % for the two readers, respectively, with a specificity of 51 % and 81 %. For tenosynovitis, the sensitivity was 67 % and 54 %, respectively, with a specificity of 87 % and 91 %. Pooled data analysis revealed an overall sensitivity of 81 % and specificity of 50 % for evaluation of synovitis. Variations in tenosynovitis scoring systems hindered pooled analyses. Eliminating Gd contrast administration resulted in low specificity for synovitis and low sensitivity for tenosynovitis, indicating that Gd contrast administration remains essential for an optimal assessment. (orig.)

  16. Phosphate-methylated DNA aimed at HIV-1 RNA loops and integrated DNA inhibits viral infectivity

    NARCIS (Netherlands)

    Buck, H. M.; Koole, L. H.; van Genderen, M. H.; Smit, L.; Geelen, J. L.; Jurriaans, S.; Goudsmit, J.

    1990-01-01

    Phosphate-methylated DNA hybridizes strongly and specifically to natural DNA and RNA. Hybridization to single-stranded and double-stranded DNA leads to site-selective blocking of replication and transcription. Phosphate-methylated DNA was used to interrupt the life cycle of the human

  17. Characteristic Features of Innovation Project Management Aimed at University Human Resource Development

    Science.gov (United States)

    Kalimullin, Aydar M.; Yungblud, Valery T.; Khodyreva, Elena A.

    2016-01-01

    The relevance of the studied issue is based on the need to develop theoretical approaches to project management at a higher educational institution taking into consideration the specifics of the subject area of the projects that ensure finding the "growth points" and addressing the long-term objectives of a university in the field of…

  18. Immunotherapy regimens for combination with photodynamic therapy aimed at eradication of solid cancers

    Science.gov (United States)

    Korbelik, Mladen

    2000-06-01

    Due to inflammatory/immune responses elicited by photodynamic therapy (PDT), this modality is particularly suitable in combination with various forms of immunotherapy for an improved therapeutic gain. A wide variety of approaches that may be applicable in this context include those focusing on amplifying the activity of particular immune cell types (neutrophils, macrophages, dendritic cells, natural killer cells, helper or cytotoxic T lymphocytes). Another type of approach is to focus on a specific phase of immune response development, which comprises the activation of non-specific inflammatory immune effectors, immune recognition, immune memory, immune rejection, or blocking of immune suppression. These different strategies call for a variety of immunotherapeutic protocols to be employed in combination with PDT. These include treatments such as: (1) non-specific immunoactivators (e.g. bacterial vaccines), (2) specific immune agents (cytokines, or other activating factors), (3) adoptive immunotherapy treatments (transfer of dendritic cells, tumor-sensitized T lymphocytes or natural killer cells), or (4) their combinations. Techniques of gene therapy employed in some of these protocols offer novel opportunities for securing a potent and persistent immune activity. Using PDT and immunotherapy represents an attractive combination for cancer therapy that is capable of eradicating both localized and disseminated malignant lesions.

  19. Aiming for Outstanding: Action Research from Students of the MSc in the Teaching of Psychology

    Science.gov (United States)

    Lintern, Fiona; Davies, Jamie; McGinty, Andrew; Fisher, Jeannine

    2014-01-01

    The first cohort of a new MSc programme is due to complete the course in August 2014. During the three-year online course students conduct several pieces of action research in their classrooms. There is little research specifically related to classroom practice in the pre-tertiary psychology classroom. The following describes the rationale and…

  20. Inactivation of bacterial pathogenic load in compost against vermicompost of organic solid waste aiming to achieve sanitation goals: A review.

    Science.gov (United States)

    Soobhany, Nuhaa; Mohee, Romeela; Garg, Vinod Kumar

    2017-06-01

    Waste management strategies for organic residues, such as composting and vermicomposting, have been implemented in some developed and developing countries to solve the problem of organic solid waste (OSW). Yet, these biological treatment technologies do not always result in good quality compost or vermicompost with regards to sanitation capacity owing to the presence of bacterial pathogenic substances in objectionable concentrations. The presence of pathogens in soil conditioners poses a potential health hazard and their occurrence is of particular significance in composts and/or vermicomposts produced from organic materials. Past and present researches demonstrated a high-degree of agreement that various pathogens survive after the composting of certain OSW but whether similar changes in bacterial pathogenic loads arise during vermitechnology has not been thoroughly elucidated. This review garners information regarding the status of various pathogenic bacteria which survived or diffused after the composting process compared to the status of these pathogens after the vermicomposting of OSW with the aim of achieving sanitation goals. This work is also indispensable for the specification of compost quality guidelines concerning pathogen loads which would be specific to treatment technology. It was hypothesized that vermicomposting process for OSW can be efficacious in sustaining the existence of pathogenic organisms most specifically; human pathogens under safety levels. In summary, earthworms can be regarded as a way of obliterating pathogenic bacteria from OSW in a manner equivalent to earthworm gut transit mechanism which classifies vermicomposting as a promising sanitation technique in comparison to composting processes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Feasibility of a transition intervention aimed at adolescents with chronic illness

    DEFF Research Database (Denmark)

    Hanghøj, Signe; Boisen, Kirsten A; Schmiegelow, Kjeld

    2018-01-01

    intervention aimed at adolescents with chronic illness focusing on declines, drop-outs, no-shows and advantages and disadvantages of participating. METHODS: We invited 236 adolescents (12-20 years) with juvenile idiopathic arthritis (JIA) to participate in a randomised controlled trial (RCT) transition...... intervention. Reasons for decline and drop-outs were calculated. Adolescents' experiences of advantages and disadvantages of participating and reasons for no-shows were investigated through focus groups and telephone interviews, which were analysed using thematic analysis. RESULTS: One hundred and twenty...... and being too busy. Advantages of participating were stated as 'participating without parents', 'trust and confidentiality', 'being able to set the agenda' and 'responsiveness'. Disadvantages were 'unclear aim of the study', 'meeting others with JIA', 'too few conversations' and 'transport issues...

  2. Synchronised and complementary coordination mechanisms in an asymmetric joint aiming task

    DEFF Research Database (Denmark)

    Skewes, Joshua Charles; Skewes, Lea; Michael, John

    2015-01-01

    Many forms of social interaction require that behaviour be coordinated in the here and now. Much research has been conducted on how people coordinate their actions in real time to achieve a joint goal, showing that people use both synchronised (i.e. symmetric) and complementary (i.e. asymmetric......) strategies. These two mechanisms have been mostly studied independently, the former in the context of rhythmic tasks, and the latter in non-rhythmic tasks. However, people often balance these two strategies in real life social interactions, in order to achieve a joint goal more effectively. Here, our aim...... was to investigate how people may implicitly balance synchronisation and complementarity in a continuous joint aiming task. We asked dyads to synchronise the timing of their clicks between targets, while changing task constraints for one member of the dyad (i.e. different task difficulties) to asymmetrically perturb...

  3. Aiming of Kirkpatrick-Baez microscope based on auxiliary optical system

    International Nuclear Information System (INIS)

    Huang Shengling; Mu Baozhong; Yi Shengzhen; Wang Xin; Wang Zhanshan; Ding Yongkun; Miao Wenyong; Dong Jianjun

    2009-01-01

    An auxiliary optical system has been designed, which can provide precise positioning for aiming Kirkpatrick-Baez (KB) microscope object location. An 8 keV X-ray imaging system by KB microscope with periodic multilayer films has been designed. The field of view and depth of field in the resolution of 5 μm are got, and then the corresponding point and depth of field in diagnostic experiments are calculated. Based on the object-image relations and precision of the KB microscope, an auxiliary visible light imaging system is designed and X-ray imaging experiments are performed, which can achieve equivalent aiming between the visible imaging system and the KB microscope. The results show that ±20 μm vertical axis plane and ±300 μm axial accuracy are achieved through the auxiliary optical path, which can meet the object point positioning requirements of the KB microscope. (authors)

  4. Management Systems for Organic EggProduction - Aiming to Improve AnimalHealth and Welfare

    DEFF Research Database (Denmark)

    Hegelund, Lene

    animal health and welfare. The aim of the project is to develop management tools for the organic egg production, aimed to secure animal health and welfare in the flocks. In the first part of the project a welfare assessment system for organic egg production was developed and tested on 10 fl ocks during......Animal health and welfare is an important part of organic husbandry, both in terms of the organic principles and owing to the consumer interest. But problems in the organic egg production resulting in high mortality and feather pecking, have led to the need for management tools in order to secure...... one production period. In the second part of the project a generic HACCP system was developed, using an expert panel analysis. The two management tools have very different approaches to improving animal health and welfare, and subsequently different methods, cost and advantages. This makes them...

  5. Research and development of an aimed magnetic lead current density-magnetic field diagnostic. Final report

    International Nuclear Information System (INIS)

    1985-01-01

    A diagnostics survey was made to provide a clear definition of advanced diagnostic needs and the limitations of current approaches in addressing those needs. Special attention was given to the adequacy with which current diagnostics are interfaced to signal processing/data acquisition devices and systems. Critical evaluations of selected alternative diagnostic techniques for future R and D activities are presented. The conceptual basis of the Aimed Magnetic Lead Gradiometric system as a current density/magnetic field diagnostic is established

  6. Three-dimensional assessment of postural tremor during goal-directed aiming.

    Science.gov (United States)

    Kelleran, K J; Morrison, S; Russell, D M

    2016-12-01

    The performance of fine motor tasks which require a degree of precision can be negatively affected by physiological tremor. This study examined the effect of different aiming positions on anterior-posterior (AP), medial-lateral (ML) and vertical (VT) postural tremor. Participants were required to aim a mock handgun at a target located in front of them at eye level. Changes in AP, ML and VT tremor from the forearm and gun barrel were assessed as a function of limb (i.e., whether one or both arms were used) and upper arm position (elbow bent or extended). Tremor was recorded using triaxial accelerometers. Results showed that, across all tasks, the ML and VT tremor for any point was characterized by two frequency peaks (between 1-4 and 8-12 Hz) with amplitude increasing from proximal (forearm) to distal (gun barrel). Interestingly, irrespective of the posture adopted, ML accelerations were of greater amplitude than VT oscillations. AP oscillations were markedly smaller compared to VT and ML tremor, did not display consistent frequency peaks, and were not altered by the arm conditions. Altering the aiming posture resulted in changes in VT and ML tremor amplitude, with oscillations being greater when using a single arm as compared to when two arms were used together. Similarly, tremor amplitude was reduced when the task was performed with the elbow bent compared to the straight arm condition. Overall, these results highlight that ML oscillations make as significant a contribution to the overall tremor dynamics as those observed in the VT direction. However, the origin of ML tremor is not simply the product of voluntary adjustments to maintain aim on the target, but also exhibits features similar to the neural generated 8-12-Hz tremor seen under postural conditions.

  7. THE AIMS OF EMPLOYABILITY AND SOCIAL INCLUSION / ACTIVE CITIZENSHIP IN LIFELONG LEARNING POLICIES IN GREECE

    OpenAIRE

    Prokou, Eleni

    2011-01-01

    The argument of this article is that during the last two decades or so, in lifelong learning policies in Greece, priority was given to the confrontation of social exclusion that stems from unemployment and, thus, to the achievement of the aims of employability and social inclusion. EU funding and the relatively centralised character of the regulated part of adult/continuing education in Greece favoured the expansion of training programmes for the unemployed. As in the 1990s, so in the 2000s, ...

  8. The retention of clean air concept in Switzerland - aims and measures

    International Nuclear Information System (INIS)

    Wanner, H.U.

    1988-01-01

    An overview of the detectable effects of air pollutants in Switzerland, with a reference to the methods available now for examination of the mostly complex pollutant effects, is given. An assessment of the emission situation in Switzerland based on the criteria given in the environmental protection legislation follows. Finally the aims, measures and time table of the air-clean keeping concept are explained, with references to the energy supply. 27 refs., 3 figs., 3 tabs

  9. Midline body actions and leftward spatial Aiming in patients with spatial neglect

    Directory of Open Access Journals (Sweden)

    Amit eChaudhari

    2015-07-01

    Full Text Available Spatial motor-intentional Aiming bias is a dysfunction in initiation/execution of motor intentional behavior, resulting in hypokinetic and hypometric leftward movements. Aiming bias may contribute to posture, balance and movement problems and uniquely account for disability in post-stroke spatial neglect. Body movement may modify and even worsen Aiming errors, but therapy techniques such as visual scanning training do not take this into account. Here, we evaluated 1 whether instructing neglect patients to move midline body parts improves their ability to explore left space, and 2 whether this has a different impact on different patients. A 68-year-old woman with spatial neglect after a right basal ganglia infarct had difficulty orienting to and identifying left-sided objects. She was prompted with four instructions: look to the left, point with your nose to the left, point with your [right] hand to the left, and stick out your tongue and point it to the left. She oriented leftward dramatically better when pointing with the tongue/nose, than she did when pointing with the hand. We then tested 9 more consecutive patients with spatial neglect using the same instructions. Only four of them made any orienting errors. Only one patient made >50% errors when pointing with the hand, and she did not benefit from pointing with the tongue/nose. We observed that pointing with the tongue could facilitate left-sided orientation in a stroke survivor with spatial neglect. If midline structures are represented more bilaterally, they may be less affected by Aiming bias. Alternatively, moving the body midline may be more permissive for leftward orienting than moving right body parts. We were not able to replicate this effect in another patient; we suspect that the magnitude of this effect may depend upon the degree to which patients have directional akinesia, spatial Where deficits, or cerebellar/frontal cortical lesions. Future research could examine these

  10. Progress of MCT Detector Technology at AIM Towards Smaller Pitch and Lower Dark Current

    Science.gov (United States)

    Eich, D.; Schirmacher, W.; Hanna, S.; Mahlein, K. M.; Fries, P.; Figgemeier, H.

    2017-09-01

    We present our latest results on cooled p-on- n planar mercury cadmium telluride (MCT) photodiode technology. Along with a reduction in dark current for raising the operating temperature ( T op), AIM INFRAROT-MODULE GmbH (AIM) has devoted its development efforts to shrinking the pixel size. Both are essential requirements to meet the market demands for reduced size, weight and power and high-operating temperature applications. Detectors based on the p-on- n technology developed at AIM now span the spectrum from the mid-wavelength infrared (MWIR) to the very long wavelength infrared (VLWIR) with cut-off wavelengths from 5 μm to about 13.5 μm at 80 K. The development of the p-on- n technology for VLWIR as well as for MWIR is mainly implemented in a planar photodetector design with a 20- μm pixel pitch. For the VLWIR, dark currents significantly reduced as compared to `Tennant's Rule 07' are demonstrated for operating temperatures between 30 K and 100 K. This allows for the same dark current performance at a 20 K higher operating temperature than with previous AIM technology. For MWIR detectors with a 20- μm pitch, noise equivalent temperature differences of less than 30 mK are obtained up to 170 K. This technology has been transferred to our small pixel pitch high resolution (XGA) MWIR detector with 1024 × 768 pixels at a 10- μm pitch. Excellent performance at an operating temperature of 160 K is demonstrated.

  11. Controlled austempering of hammer forgings aimed at pseudo normalized microstructure directly after deformation

    Directory of Open Access Journals (Sweden)

    P. Skubisz

    2017-01-01

    Full Text Available The study concerns cost-effective realization of controlled thermomechanical processing (CTMP of medium-carbon and HSLA steel aimed at producing microstructure and properties equivalent to normalized condition directly after forging. The results of theoretical and physical modeling of hot forging with subsequent heat treating adopted for industrial realization in continuous manner were verified in semi-industrial conditions of a forge plant.

  12. The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection.

    Science.gov (United States)

    Marim, Fernanda M; Franco, Miriam M Costa; Gomes, Marco Tulio R; Miraglia, Maria Cruz; Giambartolomei, Guillermo H; Oliveira, Sergio C

    2017-02-01

    The innate immune system is essential for the detection and elimination of bacterial pathogens. Upon inflammasome activation, caspase-1 cleaves pro-IL-1β and pro-IL-18 to their mature forms IL-1β and IL-18, respectively, and the cell undergoes inflammatory death termed pyroptosis. Here, we reviewed recent findings demonstrating that Brucella abortus ligands activate NLRP3 and AIM2 inflammasomes which lead to control of infection. This protective effect is due to the inflammatory response caused by IL-1β and IL-18 rather than cell death. Brucella DNA is sensed by AIM2 and bacteria-induced mitochondrial reactive oxygen species is detected by NLRP3. However, deregulation of pro-inflammatory cytokine production can lead to immunopathology. Nervous system invasion by bacteria of the genus Brucella results in an inflammatory disorder termed neurobrucellosis. Herein, we discuss the mechanism of caspase-1 activation and IL-1β secretion in glial cells infected with B. abortus. Our results demonstrate that the ASC inflammasome is indispensable for inducing the activation of caspase-1 and secretion of IL-1β upon infection of astrocytes and microglia with Brucella. Moreover, our results demonstrate that secretion of IL-1β by Brucella-infected glial cells depends on NLRP3 and AIM2 and leads to neurobrucellosis. Further, the inhibition of the host cell inflammasome as an immune evasion strategy has been described for bacterial pathogens. We discuss here that the bacterial type IV secretion system VirB is required for inflammasome activation in host cells during infection. Taken together, our results indicate that Brucella is sensed by ASC inflammasomes mainly NLRP3 and AIM2 that collectively orchestrate a robust caspase-1 activation and pro-inflammatory response.

  13. RECYCLING OF PRINTED CIRCUIT BOARDS AIMING SILVER RECOVERY: A HYDROMETALLURGICAL ROUTE STUDY

    OpenAIRE

    Marcos Paulo Kohler Caldas; Viviane Tavares de Morae; Eduardo Junca; Jorge Alberto Soares Tenório; Denise Crocce Romano Espinosa

    2015-01-01

    The aim of this paper is characterize printed circuit board of computers and propose a hydrometallurgical route for silver recovery present in its composition. Initially, the printed circuit board was comminuted in both knife and hammer mills. The comminuted material was characterized by sieve analysis, chemical analysis by inductively coupled plasma optical emission spectrometry (ICP-OES) and loss on ignition. Leaching tests were conducted in sulfuric acid, sulfuric acid in an ox...

  14. Incorporating Level-2 PSA Feature of CONPAS into AIMS-PSA Software

    Energy Technology Data Exchange (ETDEWEB)

    Han, Sang Hoon; Lim, Hogon; Ahn, Kwang Il [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    CONPAS (CONtainment Performance Analysis System) utilizes a methodology to treat containment phenomena in detail like APET but in simple way. In mid 2000's, KAERI has developed very fast cut set generator FTREX and PC's OS (Operating system) has changed into Windows 95. Thus, KAERI has developed new Level-1 PSA software, called AIMS-PSA (Advanced Information Management System for PSA) to replace KIRAP. Recently, KAERI has been developing an integrated PSA platform, called OCEANS (On-line Consolidator and Evaluator of All mode risk for Nuclear System), for the risk assessment of all power modes and all hazards. CONPAS for Level-2 PSA was developed in 1990's using the Visual Basic 6.0 compiler which is not supported any more. It needs to be updated for the integrated PSA software framework. This paper describes a study to incorporate the features of CONPAS into AIMS-PSA. The basic idea is to follow the approach of CONPAS, but in the integrated way. Various approaches for Level-2 PSA have been used since WASH-1400. APET approach of NUREG-1150 study would be most comprehensive and complex methodology for containment event tree analysis. CONPAS is the Level-2 PSA software to utilize an approach to treat containment phenomena in detail like APET but in simple way. But, new Level-2 PSA software is required to develop more integrated PSA framework. A modified approach of CONPAS is developed and incorporated in AIMS-PSA software that can handle Level-1 and Level-2 PSA in the integrated way (from the viewpoint of event tree and fault tree). AIMS-PSA combines whole Level-2 PSA model to produce a One Top fault tree and to generate cut sets in the same way as Level-1 PSA. Quantification results of Level-2 PSA such as frequency for each STC can be calculated from the minimal cut sets.

  15. Evaluation of activities aimed at preventing microbiological risks in dental practice

    OpenAIRE

    Jolanta Szymańska; Jolanta Sitkowska

    2013-01-01

    Background: Microbiological contamination of water in dental unit waterlines (DUWL) creates a risk of cross-infections, and is a source of biological risk factors in the work environment of a dentist. The aim of the study was to evaluate dentists' knowledge on DUWL microbiological contamination and the scope of activities/procedures they undertake to monitor it. Material and Methods: The questionnaire survey was conducted in 2010 among 107 Polish dentists using dental units in everyday clinic...

  16. Campaign Seeks Buy-In for High School Reforms: "Stand Up" Aims to Rouse Public Support

    Science.gov (United States)

    Robelen, Erik W.

    2006-01-01

    Kicked off the week of April 10, 2006 with a big plug on "The Oprah Winfrey Show," a new campaign spearheaded by the Bill & Melinda Gates Foundation is aiming to drum up public action to address what its organizers see as a crisis in America's public high schools. The Stand Up campaign comes as high schools have emerged as a focus of public-policy…

  17. Decreased leftward 'aiming' motor-intentional spatial cuing in traumatic brain injury.

    Science.gov (United States)

    Wagner, Daymond; Eslinger, Paul J; Barrett, A M

    2016-09-01

    To characterize the mediation of attention and action in space following traumatic brain injury (TBI). Two exploratory analyses were performed to determine the influence of spatial 'Aiming' motor versus spatial 'Where' bias on line bisection in TBI participants. The first experiment compared performance according to severity and location of injury in TBI. The second experiment examined bisection performance in a larger TBI sample against a matched control group. In both experiments, participants bisected lines in near and far space using an apparatus that allowed for the fractionation of spatial Aiming versus Where error components. In the first experiment, participants with severe injuries tended to incur rightward error when starting from the right in far space, compared with participants with mild injuries. In the second experiment, when performance was examined at the individual level, more participants with TBI tended to incur rightward motor error compared to controls. TBI may cause frontal-subcortical cognitive dysfunction and asymmetric motor perseveration, affecting spatial Aiming bias on line bisection. Potential effects on real-world function need further investigation. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  18. Regional CO2 budget, countermeasures and reduction aims for the Alpine tourist region of Davos, Switzerland

    International Nuclear Information System (INIS)

    Walz, A.; Calonder, G.-P.; Hagedorn, F.; Lardelli, C.; Lundstroem, C.; Stoeckli, V.

    2008-01-01

    In its latest report, the Intergovernmental Panel on Climate Change (IPCC) concludes that global climate change can still be slowed down if greenhouse gas emissions are rapidly and strongly reduced. We present a detailed regional CO 2 budget for the Alpine tourist region of Davos, Switzerland, including emissions and potential sinks. The aim of the study was (1) to estimate the most important CO 2 sources and sinks, (2) to identify the most efficient reduction measures and (3) to assess the feasibility of different reduction targets. The results show that the emissions due to heating contribute to a proportion of 86.3% to the total budget, which is mainly due to the harsh local climate and the tourism-focused local economy. They also show that the yearly CO 2 emissions per capita in Davos exceed the Swiss average of 6 tonnes by 25%. The augmentation of the carbon pool through the natural environment compares to 10.3% of the total emissions, and further afforestation of the community forest can contribute to an improvement of the total budget by 2.6%. The reduction aim of -15% until 2015 (compared with 2004), as set by the municipality itself, could be easily reached through better building insulation and the use of renewable energy sources. More ambitious aims, such as a 2000 W-society or CO 2 neutrality, however, will not be realised without major drawbacks in living standards

  19. [Electronic parent-child health records--potentials, aims and international experience].

    Science.gov (United States)

    Piso, B; Mathis-Edenhofer, S; Schramm, F; Wild, C

    2014-04-01

    Against the background of a planned re-orientation of the Austrian maternity and child programme, which might include an electronic instead of paper-based realisation, this article aims to give an overview of international pilot projects of electronic parent-child preventive care initiatives (ePCPI) as well as their aims, potentials and constraints. A literature search in databases and hand search for international (pilot) projects was undertaken. 9 of the 30 identified ePCPI can be treated as electronic parent and/or child health records, which have been realised within a comprehensive electronic health record, as an electronic version of a paper-based document or as a centre-based IT solution. Only a few ePCPI use the additional potential of health services planning and evaluation besides core components (e. g., administration of care) and facilitate systemic learning based on feedback and evaluation -cycles. Based on experiences from international ePCPIs some core components of successful planning and implementation, like the definition of aims and their monitoring, the constitution of teams responsible for planning and conception and the early involvement of end-users and stakeholders, should be considered to minimise avoidable mistakes. Consequent technology assessments, including those of IT-based interventions, are required to allow a reflected approach. © Georg Thieme Verlag KG Stuttgart · New York.

  20. Internet Use with Learning Aim: Views of German Language Pre-Service Teachers

    Directory of Open Access Journals (Sweden)

    Mukadder Seyhan Yücel

    2011-10-01

    Full Text Available The aim of this study is to indicate the views of teacher candidates of German Language Department at Education Faculty, Trakya University about the use of internet with the aim of learning. This study has designed as phenomenology which is one of the qualitative research methods. The study data were obtained via semi-constructed interview technique and the content analysis technique was used in the data analysis. In the research, the findings gathered from the interviews with the teacher candidates are presented in themes, and then interpreted. Considering findings of the study, it has been seen that Internet should be used for learning-teaching purpose. Teacher candidates of German Language support the fact that Internet has a crucial role in education, and particularly it is useful and essential as Internet provides lots of opportunities for German Language Teaching such as authentic study samples, rich materials and exercises on skills, contemporary videos reflecting German culture or film sections. Internet is also a good material which provides accessing various information and also realizing and sharing many goals. If the information is gathered via audio and visual ways, it will be retentive. Thus, German Language teacher candidates can have opportunity to study on the foreign language and its culture through Internet. Furthermore, they have met the contemporary approaches like realizing self-directed learning individually. That’s why, the views of German Language pre-service teacher about the use of Internet with the aim of learning are very important.

  1. High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs

    Directory of Open Access Journals (Sweden)

    Angelina García

    2015-09-01

    Full Text Available The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA in the same samples. A total of 521 healthy unrelated individuals living in 13 villages of the Córdoba and San Luis provinces were tested. The individuals were genotyped for ten autosomal ancestry informative markers (AIMs. Allele frequencies were compared with those of African, European and Native American populations, chosen to represent parental contributions. The AIM estimates indicated a greater influence of the Native American ancestry as compared to previous studies in the same or other Argentinean regions, but smaller than that observed with the mtDNA tests. These differences can be explained, respectively, by different genetic contributions between rural and urban areas, and asymmetric gene flow occurred in the past. But a most unexpected finding was the marked interpopulation genetic homogeneity found in villages located in diverse geographic environments across a wide territory, suggesting considerable gene flow.

  2. COPD Multidisciplinary Team Meetings in the United Kingdom: Health Care Professionals' Perceptions of Aims and Structure.

    Science.gov (United States)

    Kruis, Annemarije L; Soljak, Michael; Chavannes, Niels H; Elkin, Sarah L

    2016-10-01

    Over the last 10 years, community and hospital-based multidisciplinary teams (MDTs) have been set up for the management of patients with chronic obstructive pulmonary disease (COPD) in the UK. Meetings of the MDTs have become a regular occurrence, mostly on healthcare professionals' own initiatives. There are no standardized methods to conduct an MDT meeting, and although cancer MDT meetings are widely implemented, the value and purpose of COPD MDT meetings are less clear. Therefore, the aim of this study was to conduct a cross-sectional descriptive online survey to explore COPD MDT members' perceptions of the purpose and usefulness of MDT meetings, and to identify suggestions or requirements to improve the meetings. In total, we received 68 responses from 10 MDTs; six teams (n = 36 members) were located in London and four (n = 32 members) outside. Analysis of the replies by two independent researchers found that MDT meetings aim to optimise management and improve pathways for respiratory patients by improving communication between providers across settings and disciplines. Education of the MDT members also occurs with the aim of safer practice. Discussed patients are characterised by (multiple) co-morbidities, frequent exacerbations and admissions, social and mental health problems, unclear diagnosis and suboptimal responses to interventions. Members reported participating in a COPD MDT as very useful (74%) or useful (20%). Meetings could be improved by ensuring attendance through requirement in job plans, by clear documentation and sharing of derived plans with a wider audience including general practitioners and patients.

  3. C3a Enhances the Formation of Intestinal Organoids through C3aR1

    Directory of Open Access Journals (Sweden)

    Naoya Matsumoto

    2017-09-01

    Full Text Available C3a is important in the regulation of the immune response as well as in the development of organ inflammation and injury. Furthermore, C3a contributes to liver regeneration but its role in intestinal stem cell function has not been studied. We hypothesized that C3a is important for intestinal repair and regeneration. Intestinal organoid formation, a measure of stem cell capacity, was significantly limited in C3-deficient and C3a receptor (C3aR 1-deficient mice while C3a promoted the growth of organoids from normal mice by supporting Wnt-signaling but not from C3aR1-deficient mice. Similarly, the presence of C3a in media enhanced the expression of the intestinal stem cell marker leucine-rich repeat G-protein-coupled receptor 5 (Lgr5 and of the cell proliferation marker Ki67 in organoids formed from C3-deficient but not from C3aR1-deficient mice. Using Lgr5.egfp mice we showed significant expression of C3 in Lgr5+ intestinal stem cells whereas C3aR1 was expressed on the surface of various intestinal cells. C3 and C3aR1 expression was induced in intestinal crypts in response to ischemia/reperfusion injury. Finally, C3aR1-deficient mice displayed ischemia/reperfusion injury comparable to control mice. These data suggest that C3a through interaction with C3aR1 enhances stem cell expansion and organoid formation and as such may have a role in intestinal regeneration.

  4. Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses

    DEFF Research Database (Denmark)

    Gottwein, Judith; Scheel, Troels; Høgh, Mette

    2007-01-01

    (immunostaining), HCV RNA titers (real-time PCR), and infectivity titers (50% tissue culture infectious dose). The role of mutations identified by sequencing of recovered S52/JFH1 viruses was analyzed by reverse genetics studies. RESULTS: S52/JFH1 and J6/JFH viruses passaged in Huh7.5 cells showed comparable......BACKGROUND & AIMS: Recently, full viral life cycle hepatitis C virus (HCV) cell culture systems were developed for strain JFH1 (genotype 2a) and an intragenotypic 2a/2a genome (J6/JFH). We aimed at exploiting the unique JFH1 replication characteristics to develop culture systems for genotype 3a......, which has a high prevalence worldwide. METHODS: Huh7.5 cells were transfected with RNA transcripts of an intergenotypic 3a/JFH1 recombinant with core, E1, E2, p7, and NS2 of the 3a reference strain S52, and released viruses were passaged. Cultures were examined for HCV core and/or NS5A expression...

  5. Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses

    DEFF Research Database (Denmark)

    Gottwein, J.M.; Scheel, Troels Kasper Høyer; Hoegh, A.M.

    2007-01-01

    BACKGROUND & AIMS: Recently, full viral life cycle hepatitis C virus (HCV) cell culture systems were developed for strain JFH1 (genotype 2a) and an intragenotypic 2a/2a genome (J6/JFH). We aimed at exploiting the unique JFH1 replication characteristics to develop culture systems for genotype 3a......, which has a high prevalence worldwide. METHODS: Huh7.5 cells were transfected with RNA transcripts of an intergenotypic 3a/JFH1 recombinant with core, E1, E2, p7, and NS2 of the 3a reference strain S52, and released viruses were passaged. Cultures were examined for HCV core and/or NS5A expression...... (immunostaining), HCV RNA titers (real-time PCR), and infectivity titers (50% tissue culture infectious dose). The role of mutations identified by sequencing of recovered S52/JFH1 viruses was analyzed by reverse genetics studies. RESULTS: S52/JFH1 and J6/JFH viruses passaged in Huh7.5 cells showed comparable...

  6. Aims and limitations in the use of antipeptide antibodies in molecular biology.

    Science.gov (United States)

    Chersi, A; Di Modugno, F; Rosano, L

    1997-07-01

    Antibodies to peptides obtained by synthesis and, to a much lesser extent, prepared by enzymatic digestion of proteins, have been widely used in the last ten years in a variety of immunochemical and biological investigations. There are however several limitations in the correct utilization of such reagents. In fact, in spite of their 'predetermined specificity', antipeptide antibodies often fail to discriminate related molecules, and their reactivity with native proteins may be scarce or even absent, even if the peptide has been selected from surface regions of the protein. Our critical point of view, concerning two main aspects of antipeptide antibody features, i.e. specificity and reactivity, will be presented here, as confronted with information from the available literature. We have selected a restricted number of references among hundreds of publications dealing with antipeptide antibodies: for sure we neglected outstanding papers on the subject, and we apologize in advance.

  7. Teleradiology requirements and aims in Germany and Europe: status at the beginning of 2000

    Energy Technology Data Exchange (ETDEWEB)

    Walz, M.; Brill, C.; Bolte, R.; Reimann, C.; Weisser, G.; Lehmann, K.J.; Georgi, M. [Department of Clinical Radiology, Klinikum Mannheim, University of Heidelberg (Germany); Cramer, U. [Management of the Profession Organization of German Radiologists, Munich (Germany); Wein, B. [Clinic for Diagnostic Radiology, Technical University of Aachen (Germany); Haimerl, M. [Institute for Algorithms and Cognitive Systems, University of Karlsruhe (Germany); Loose, R. [Department of Interventional and Diagnostic Radiology, Klinikum Nuernberg Nord, D-90340 Nuremburg (Germany)

    2000-09-01

    Specific radiological requirements have to be considered for realization of telemedicine. In this article the goals and requirements for an extensive implementation of teleradiology are defined from the radiological user's point of view. Necessary medical, legal and professional prerequisites for teleradiology are presented. Superior requirements, such as data security and privacy or standardization of communication, must be realized. Application specific requirements, e. g. quality and extent of teleradiological functions as well as technological alternatives, are discussed. Each project must be carefully planned in relation to one's own needs, extent of functions and system selection. Topics like legal acceptance of electronic documentation, reimbursement of teleradiology and liability must be clarified in the future. (orig.)

  8. Specific Language Impairment

    Science.gov (United States)

    ... Home » Health Info » Voice, Speech, and Language Specific Language Impairment On this page: What is specific language ... percent of children in kindergarten. What is specific language impairment? Specific language impairment (SLI) is a language ...

  9. H12: Examination of safety assessment aims, procedures and results from a wider perspective

    International Nuclear Information System (INIS)

    Neall, F.B; Smith, P.A.

    2004-04-01

    Safety assessment (SA) are a familiar tool for the evaluation of disposal concepts for radioactive waste. There is, however, often confusion in the wider community about the aims, methods and results used in SA. This report aims to present the H12 SA in a way that makes the assessment process clearer and the implications of the results more meaningful both to workers within the SA field and to a wider technical audience. The reasonableness of the assessment results, the quality of the models and databases and redundancy within the natural and engineered barrier system have been considered. A number of recent and somewhat older SAs that address a range of different waste types, host rocks and disposal concepts have been considered, and comparisons made to H12. A further aim is to put both doses and timescales in a more meaningful context. It has been necessary to: consider ways of demonstrating the meaningfulness of calculations that give results for many thousands of years in the future; provide a framework timescale as a context for SA results over long times; demonstrate the smallness of the risk associated with the doses by comparison with other radiological and non-radiological risks. The perception of risk, which is a critical issue for public acceptance of radioactive waste disposal and must be considered when seeking to present safety assessment results 'in perspective' to a wider audience, is also discussed. It is concluded that H12 is comparable in many ways to assessments carried out internationally. Some assumptions are somewhat arbitrary reflecting the generic stage of the Japanese programme, and are likely to become better founded in future exercises. Nevertheless, H12 provides a clear and well-founded message that it is feasible to site and construct a safe repository from HLW in Japan. (author)

  10. Development of a Minimum Data Set (MDS) for C-Section Anesthesia Information Management System (AIMS).

    Science.gov (United States)

    Sheykhotayefeh, Mostafa; Safdari, Reza; Ghazisaeedi, Marjan; Khademi, Seyed Hossein; Seyed Farajolah, Seyedeh Sedigheh; Maserat, Elham; Jebraeily, Mohamad; Torabi, Vahid

    2017-04-01

    Caesarean section, also known as C-section, is a very common procedure in the world. Minimum data set (MDS) is defined as a set of data elements holding information regarding a series of target entities to provide a basis for planning, management, and performance evaluation. MDS has found a great use in health care information systems. Also, it can be considered as a basis for medical information management and has shown a great potential for contributing to the provision of high quality care and disease control measures. The principal aim of this research was to determine MDS and required capabilities for Anesthesia information management system (AIMS) in C-section in Iran. Data items collected from several selected AIMS were studied to establish an initial set of data. The population of this study composed of 115 anesthesiologists was asked to review the proposed data elements and score them in order of importance by using a five-point Likert scale. The items scored as important or highly important by at least 75% of the experts were included in the final list of minimum data set. Overall 8 classes of data (consisted of 81 key data elements) were determined as final set. Also, the most important required capabilities were related to airway management and hypertension and hypotension management. In the development of information system (IS) based on MDS and identification, because of the broad involvement of users, IS capabilities must focus on the users' needs to form a successful system. Therefore, it is essential to assess MDS watchfully by considering the planned uses of data. Also, IS should have essential capabilities to meet the needs of its users.

  11. Specialized cockpit displays, symbology, and control mechanization for air vehicle weapons aiming and employment

    Science.gov (United States)

    Greeley, Kevin W.

    2001-09-01

    Throughout the history of aviation, air vehicles have been developed for military applications in a number of roles, especially the use of weapons to attack targets on the ground and in the air. The complex dynamics of weapons aiming and employment from air vehicles has driven the design of a wide variety of specialized software and operator interfaces. The task of weapons employment in an air vehicle is particularly challenging when the target is itself an air vehicle. This paper examines specialized implementations in cockpit display symbology for weapons employment of modern air-to-air missiles.

  12. Determining the marketing mix for a start-up travel agency aimed at the Belgian market

    OpenAIRE

    Hanák, Marek

    2014-01-01

    This thesis suggests a marketing mix consisting of 4 P's for a start-up travel agency. It created a product according to the quantitative research, n=140, and a qualitative research on the Belgian market. It includes the price of the product according to a competitor analysis, price expectation of the segment and a calculation of all costs connected with providing the service. It suggests also a promotion strategy aimed at the target audience and describes the place in terms point of sale ded...

  13. ECOLOGICAL PROBLEMS OF THE CAUCASUS AND THE AIMS OF MODELING OF SUSTAINABLE FUTURE OF THE REGION

    International Nuclear Information System (INIS)

    Chkhaidze, N.; Tsitskishvili, M.; Tsitskishvili, M.; Japaridze, L.

    2008-01-01

    The ecological crisis, the main alternative of the progress of modern civilization, has posed a number of problems, including educational ones, to the developing world community. In this work, the basic criteria of differentation of ecology from other natural sciences - the existence and the indissoluble unity of ''ecological triad'' are formulated; the basic problems of ecology of the Caucasus are revealed, and hence the basic aims of environmental protection for achievement of sustainable development of the region are formulated. (author)

  14. Law proposition aiming to organize the sustainable management of radioactive wastes

    International Nuclear Information System (INIS)

    Bataille, Ch.; Ayrault, J.M.; Hollande, F.; Dose, F.; Dumont, J.L.; Brottes, F.; Le Deaut, J.Y.

    2006-02-01

    In 1991 the France decided to intensify its researches in the high activity radioactive wastes management domain. The law of the 30 December 1991 relative to the radioactive wastes management, decided that a period of 15 years would be devoted to the research of very long dated solutions. This law proposition takes into account these researches results and aims to define a policy of radioactive wastes management in the framework of a sustainable development. The authors present and discuss the different articles of the law proposition. (A.L.B.)

  15. Willingness-to-pay for a population program aimed at reducing dietary salt in Denmark

    DEFF Research Database (Denmark)

    Kristiansen, Ivar Sønbø; Gyrd-Hansen, Dorte; Nexøe, Jørgen

    2006-01-01

    BACKGROUND: High intake of salt increases blood pressure and the risk of cardiovascular disease. Population programs aimed at reducing dietary salt may be cost-effective, but little is known about people's valuation of such programs. METHODS: A random sample (n = 924) of Danish people aged 20......-74 was interviewed in-person in year 2000. They were asked how much they would be willing to contribute in additional tax for a population program that would half the intake of salt. The respondents were randomized to presentation of effectiveness format (number-needed-to-treat (NNT), relative risk reduction (RRR...

  16. Appearance and reality. Socrates’ aims and strategies in Plato’s Cratylus

    DEFF Research Database (Denmark)

    Jørgensen, Steffen Lund

    What are Socrates ’ aims and strategies in the Cratylus? Does Socrates seek to convince his interlocutors that there is a source of linguistic correctness, which goes beyond human agreement, and which really determines whether the name of something is the correct name? Or does Socrates seek...... to achieve the opposite? What strategies does Socrates use, and why? These questions are central to my thesis, which offer s a new interpretation of Plato’s Cratylus . In the thesis I argue that Socrates really does seek to convince his interlocutors that there is a “natural correctness of names...

  17. Sugli obiettivi di una riforma tributaria in Italia. (The aims of a taxation reform in Italy

    Directory of Open Access Journals (Sweden)

    C. COSCIANI

    2014-07-01

    Full Text Available The drawbacks and deficiencies of the Italian fiscal system have become such and so many that a structural revision is urgent both concerning legislation and the organisation of the tax system. The first aim of a reform must be to make the system clear and simple. Secondly, the progressiveness of the system must be announced. Third, the fiscal system should become an instrument of economic planning. The paper puts forward a reform proposal and draws a set of priorities for the reorganisation of fiscal structures and jurisdictions in Italy.JEL: E62, H21, H30

  18. Common Aims, Values And Principles Of Intellectual Property, Right To Competence And Others Rights

    Directory of Open Access Journals (Sweden)

    Juan Carlos Riofrío Martínez-Villalba

    2013-01-01

    Full Text Available This paper aims the definition of which are the pourposes, values and common principles of intellectual property, competence law of advertising, consumer and information. It shows how the principles are anchored in values, and these in turn into rights purposes, making palpable the hierarchy such purposes, values ​​and principles have in the legal system. Thus, the outcome of the research is threefold: (i definition of the purposes, values ​​and principles common to these areas of law, (ii its interface, and (iii their ranking.

  19. Collection and valuation of numerical models with the aim to investigate the impact of aircraft emissions

    International Nuclear Information System (INIS)

    Dameris, M.

    1993-01-01

    Numerical models which are used to simulate the dynamics and chemistry of the Earth atmosphere are an important expedient to improve the knowledge of atmospheric processes. With such models it is possible to investigate single effects separately and to estimate their meaning for the whole system. It is possible to make sensitivity studies as well as calculations of different scenarios. This paper aims to describe different models which are available in the present time and which can be used for investigations dealing with the impact of aircraft emission on the Earth climate. Actual deficits of the modelling of atmospheric processes are discussed and the subsequent conclusions are presented. (orig.) 49 refs [de

  20. Analysis of different alternatives for a reactor aimed to produce Co60. Neutronic part

    International Nuclear Information System (INIS)

    Relloso, J.M.

    1990-01-01

    Different alternatives are presented for a reactor aimed to produce radioisotopes with a low enrichment fuel element geometrically equal to those of low enrichment. Different alternatives are presented which essentially differ in the core's configuration, fuel management and 'meat' fuel material: U3O8, U3Si or U3Si2 in aluminium matrix. Fluxes at different irradiation positions and power full peak factors are described for each case. The main aspects to be taken into account for cobalt irradiation and the method to be followed to measure the reactor as a function of a required production are presented. (Author) [es

  1. America: AGA [American Gas Association] initiative aims to boost gas demand

    International Nuclear Information System (INIS)

    Fraser, K.M.

    1992-01-01

    This article focuses on the aim of the American Gas Association to increase natural gas demand in the key areas of gas electric generation, natural gas vehicles, gas cooling, and conversion of oil burning facilities, electric water heaters and household appliances such as space heating, stoves, washers and lighting. The need to improve the reliability of natural gas supplies is discussed. It is anticipated that natural gas will not replace coal as the main energy source for power generation, but that it will help utilities to meet environmental regulations. (UK)

  2. Design of advanced solar homes aimed at net-zero annual energy consumption in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Athienitis, Andreas

    2010-09-15

    This paper overviews the design of three sustainable low or net-zero energy solar homes in Canada. The major features of the houses are: 1. direct gain passive solar design that emphasizes utilization of distributed thermal mass in the equatorial-facing part of the ground floor; 2. a building-integrated photovoltaic-thermal system (BIPV/T); 3. a two-stage ground-source heat pump used to heat/cool air in the house or an air source heat pump using BIPV/T air as the source to heat a storage tank; 4. a floor heating system integrated in the floor mass of the direct gain zone; 5. a multizone programmable thermostat.

  3. Quantifying creatinine and urea in human urine through Raman spectroscopy aiming at diagnosis of kidney disease

    Science.gov (United States)

    Saatkamp, Cassiano Junior; de Almeida, Maurício Liberal; Bispo, Jeyse Aliana Martins; Pinheiro, Antonio Luiz Barbosa; Fernandes, Adriana Barrinha; Silveira, Landulfo, Jr.

    2016-03-01

    Due to their importance in the regulation of metabolites, the kidneys need continuous monitoring to check for correct functioning, mainly by urea and creatinine urinalysis. This study aimed to develop a model to estimate the concentrations of urea and creatinine in urine by means of Raman spectroscopy (RS) that could be used to diagnose kidney disease. Midstream urine samples were obtained from 54 volunteers with no kidney complaints. Samples were subjected to a standard colorimetric assay of urea and creatinine and submitted to spectroscopic analysis by means of a dispersive Raman spectrometer (830 nm, 350 mW, 30 s). The Raman spectra of urine showed peaks related mainly to urea and creatinine. Partial least squares models were developed using selected Raman bands related to urea and creatinine and the biochemical concentrations in urine measured by the colorimetric method, resulting in r=0.90 and 0.91 for urea and creatinine, respectively, with root mean square error of cross-validation (RMSEcv) of 312 and 25.2 mg/dL, respectively. RS may become a technique for rapid urinalysis, with concentration errors suitable for population screening aimed at the prevention of renal diseases.

  4. Thailand's Low-Carbon Scenario 2050: The AIM/CGE analyses of CO2 mitigation measures

    International Nuclear Information System (INIS)

    Thepkhun, Panida; Limmeechokchai, Bundit; Fujimori, Shinichiro; Masui, Toshihiko; Shrestha, Ram M.

    2013-01-01

    Climate change and CO 2 mitigation have become increasingly important environmental issues. Recently Thailand has proposed policies on GHG mitigation such as Thailand’s Nationally Appropriate Mitigation Action (NAMA), which aims at GHG mitigation in the energy sector. This study used the computable general equilibrium (CGE) model, called “AIM/CGE” model, to analyse GHG mitigation measures under emission trading and carbon capture and storage (CCS) technology in Thailand. Results show that the international free emission trading policy can drive more GHG reduction by decreasing energy supply and demand, and increasing prices of emissions. The CCS technologies would balance emission reduction but they would reduce energy efficiency improvement and renewable energy utilization. In the energy security aspect, the policy options in this study would improve energy security, energy import dependency, and co-benefits of GHG mitigation in forms of improving local air quality. Results are also helpful to GHG mitigation policy in developing countries. -- Highlights: •A Computable General Equilibrium (CGE) model was used to analyze GHG mitigation policies in Thailand. •The CCS and emission trading will increase GHG mitigation in Thailand. •The 30% GHG mitigation target with 50% emission trading will give the best result in GDP. •The share of biomass resource and energy efficiency will decrease with CCS. •The emission trading will play an important role in decreasing fossil consumption and increasing renewable energy utilization

  5. Export Promotion Aims and Reality: A Comparison of the Iberian, Baltic and Central European Region

    Directory of Open Access Journals (Sweden)

    Éltető Andrea

    2017-06-01

    Full Text Available As a consequence of the international crisis in 2008-2009, the role of exports in economic growth came into focus in most countries. Exports of EU Member States gained momentum from 2010 onward but with certain changes in their structure and direction. In several countries, the turn towards non-EU areas, such as China or Latin America was part of the state export strategy. On the one hand, our article describes these foreign trade strategies and their institutional framework of the Iberian, Baltic and Central European governments, detecting possible similarities. On the other hand, we analyse recent export data. This way we can get a picture on the structure and direction of exports of periphery economies and this can be compared to the aims of the given states. Our hypothesis is that there is a gap between the reality and the intentions of the governments. The size of this gap varies and is influenced by certain factors such as the different involvement of multinational companies in foreign trade or the different economic structure of these countries. In our paper we list which countries adopted a government strategy and with what aim. We provide a short literature review on state trade promotion policies and discuss these policies and their institutions in the Baltic, Visegrád and Iberian countries.

  6. Design and validation of a GNC system for missions to asteroids: the AIM scenario

    Science.gov (United States)

    Pellacani, A.; Kicman, P.; Suatoni, M.; Casasco, M.; Gil, J.; Carnelli, I.

    2017-12-01

    Deep space missions, and in particular missions to asteroids, impose a certain level of autonomy that depends on the mission objectives. If the mission requires the spacecraft to perform close approaches to the target body (the extreme case being a landing scenario), the autonomy level must be increased to guarantee the fast and reactive response which is required in both nominal and contingency operations. The GNC system must be designed in accordance with the required level of autonomy. The GNC system designed and tested in the frame of ESA's Asteroid Impact Mission (AIM) system studies (Phase A/B1 and Consolidation Phase) is an example of an autonomous GNC system that meets the challenging objectives of AIM. The paper reports the design of such GNC system and its validation through a DDVV plan that includes Model-in-the-Loop and Hardware-in-the-Loop testing. Main focus is the translational navigation, which is able to provide online the relative state estimation with respect to the target body using exclusively cameras as relative navigation sensors. The relative navigation outputs are meant to be used for nominal spacecraft trajectory corrections as well as to estimate the collision risk with the asteroid and, if needed, to command the execution of a collision avoidance manoeuvre to guarantee spacecraft safety

  7. Whole-body vibration training as complement to programs aimed at weight loss.

    Science.gov (United States)

    Cristi-Montero, Carlos; Cuevas, María J; Collado, Pilar S

    2013-01-01

    Whole-body vibration training (WBVT) has been shown to be an extremely useful tool for increasing muscle mass, bone tissue, muscle power, flexibility, and strength, among others. However, to date, there are few studies on the effects of WBVT on energy metabolism and whether this tool could be able to enhance weight loss in addition to a nutritional plan and/or exercise. The aim of this review is to analyse the most recent studies on vibration training in order to determine whether this method constitutes a reliable complement to programs aimed at weight loss. An updated literature search was conducted using PubMed, SciELO and SPORTDiscus. In addition, a detailed search was also performed from references given in selected studies. WBVT appears to be associated with three pathways involved in weight loss: inhibition of adipogenesis and reduction of fat mass, increased energy expenditure, and increase in muscle mass. After analysing the literature, none of the results for the proposed pathways are consistent, and indeed are often contradictory. Further in-depth research is required on this subject. However, WBVT would appear to be a safe method, and may possibly yield benefits, mainly as regards muscle mass, which in turn might promote weight loss when combined with a nutritional plan and a traditional exercise program. Copyright © AULA MEDICA EDICIONES 2013. Published by AULA MEDICA. All rights reserved.

  8. ECONOMIC EVALUATION OF TAX POLICY FOR INNOVATIONS AIMED AT INCREASING OIL RECOVERY

    Directory of Open Access Journals (Sweden)

    Tokarev A. N.

    2014-03-01

    Full Text Available Resource base in the Russian oil industry determines the need for the development and application of new technologies. The results of the application of innovative technologies are characterized by considerable uncertainty. Aim of this study is to develop a methodology for estimation the tax policy to encourage innovative technologies (taking into account the uncertainty of results of their application. Experience in the application of new technologies in the Russian oil companies analyzed. The developed approach (tools based on the methods of evaluation of investment projects and the Monte Carlo method. Estimates of the effectiveness of oil projects, taking into account uncertainty in the results of application of innovative technologies, presented. Stimulation of the use of new technologies should be integrated with measures to promote competition and the establishment of mechanisms of orienting the oil companies to the rational development of mineral resources. The state should adopt policies aimed at improving oil recovery, including the tax system that encourages innovation. State should create conditions for stability and protection of the interests of companies that invest in a long process of development and application of new technologies to improve oil recovery. The developed approach can be used during formation and implementation of innovation policy in the oil companies.

  9. Informatics in radiology: automated structured reporting of imaging findings using the AIM standard and XML.

    Science.gov (United States)

    Zimmerman, Stefan L; Kim, Woojin; Boonn, William W

    2011-01-01

    Quantitative and descriptive imaging data are a vital component of the radiology report and are frequently of paramount importance to the ordering physician. Unfortunately, current methods of recording these data in the report are both inefficient and error prone. In addition, the free-text, unstructured format of a radiology report makes aggregate analysis of data from multiple reports difficult or even impossible without manual intervention. A structured reporting work flow has been developed that allows quantitative data created at an advanced imaging workstation to be seamlessly integrated into the radiology report with minimal radiologist intervention. As an intermediary step between the workstation and the reporting software, quantitative and descriptive data are converted into an extensible markup language (XML) file in a standardized format specified by the Annotation and Image Markup (AIM) project of the National Institutes of Health Cancer Biomedical Informatics Grid. The AIM standard was created to allow image annotation data to be stored in a uniform machine-readable format. These XML files containing imaging data can also be stored on a local database for data mining and analysis. This structured work flow solution has the potential to improve radiologist efficiency, reduce errors, and facilitate storage of quantitative and descriptive imaging data for research. Copyright © RSNA, 2011.

  10. You prime what you code: The fAIM model of priming of pop-out.

    Directory of Open Access Journals (Sweden)

    Wouter Kruijne

    Full Text Available Our visual brain makes use of recent experience to interact with the visual world, and efficiently select relevant information. This is exemplified by speeded search when target- and distractor features repeat across trials versus when they switch, a phenomenon referred to as intertrial priming. Here, we present fAIM, a computational model that demonstrates how priming can be explained by a simple feature-weighting mechanism integrated into an established model of bottom-up vision. In fAIM, such modulations in feature gains are widespread and not just restricted to one or a few features. Consequentially, priming effects result from the overall tuning of visual features to the task at hand. Such tuning allows the model to reproduce priming for different types of stimuli, including for typical stimulus dimensions such as 'color' and for less obvious dimensions such as 'spikiness' of shapes. Moreover, the model explains some puzzling findings from the literature: it shows how priming can be found for target-distractor stimulus relations rather than for their absolute stimulus values per se, without an explicit representation of relations. Similarly, it simulates effects that have been taken to reflect a modulation of priming by an observers' goals-without any representation of goals in the model. We conclude that priming is best considered as a consequence of a general adaptation of the brain to visual input, and not as a peculiarity of visual search.

  11. Empowering employees with chronic diseases: process evaluation of an intervention aimed at job retention.

    Science.gov (United States)

    Varekamp, Inge; Krol, Boudien; van Dijk, Frank J H

    2011-01-01

    Employees with a chronic disease may experience work-related problems that contribute to the risk of job loss. We developed a group-based intervention programme aimed at clarifying problems, making these a subject of discussion at work, and realizing solutions. This process evaluation investigates the intervention's feasibility and the satisfaction of 64 participants in eight groups. Data were collected through process evaluation forms and self-report questionnaires. The recruitment of participants was time-consuming. Highly educated women working in the service sector were overrepresented. The programme was administered as planned, although components were sometimes only discussed briefly, due to lack of time. Satisfaction with the overall programme among participants was high; it was perceived as effective and there were only three dropouts. In particular, the focus on feelings and thoughts about having a chronic disease was highly valued, as were the exchange of experiences and role-playing directed at more assertive communication. A vocational rehabilitation programme aimed at job retention is feasible and is perceived to be effective. Such a programme should address psychosocial aspects of working with a chronic disease beside practical problems. The recruitment of participants is time-consuming. Cooperation with outpatient clinics is necessary in order to reach all groups of employees with a chronic disease that might benefit from job retention programmes. ISRCTN77240155.

  12. Impact of Relational Coordination on Nurse Job Satisfaction, Work Engagement and Burnout: Achieving the Quadruple Aim.

    Science.gov (United States)

    Havens, Donna Sullivan; Gittell, Jody Hoffer; Vasey, Joseph

    2018-03-01

    To explore how relational coordination, known to enhance quality and efficiency outcomes for patients and hospitals, impacts direct care nurse outcomes such as burnout, work engagement, and job satisfaction, addressing the "Quadruple Aim," to improve the experience of providing care. Hospitals are complex organizations in which multiple providers work interdependently, under conditions of uncertainty and time constraints, to deliver safe quality care despite differences in specialization, training, and status. Relational coordination-communicating and relating for the purpose of task integration-is known to improve quality, safety, and efficiency under these conditions, but less is known about its impact on the well-being of direct care providers themselves. Surveys measuring relational coordination among nurses and other types of providers as well as job-related outcomes in 5 acute care community hospitals were completed by direct care RNs. Relational coordination was significantly related to increased job satisfaction, increased work engagement, and reduced burnout. Relational coordination contributes to the well-being of direct care nurses, addressing the Quadruple Aim by improving the experience of providing care.

  13. A review on the availability of ecological data aiming new researches in Peri Lagoon

    Directory of Open Access Journals (Sweden)

    Maurício Mello Petrucio

    2008-06-01

    Full Text Available The increase in population as well as the water resource demand has been intensifying the human influence in Peri Lagoon basin. A review on the availability of data concerning the ecology of Peri Lagoon was made, aiming at the development of new researches to understand the functioning of this ecosystem. This information can contribute to the elaboration of a conservation proposal and sustainable use of the Lagoon in the future. High cyanobacteria density (Cylindrospermopsis raciborskii was detected in the Lagoon waters, which happens to be a risky situation for the ecosystem’s health and consequently for the population. The review highlights a lack of available information about the dynamics, functioning and structure of aquatic communities, as well as their relationships with the surrounding area and the infl uence of abiotic factors. Series of continuum data with respect to time are also considered to be lacking. Educational, political and social practices in environmental conservation are necessary, aiming at the management and sustainable use of Peri Lagoon basin. These practices will guarantee water resource quality and availability for the current and future generations.

  14. Activities aimed at encouraging children to suicidal behavior: judicial-psychological examination

    Directory of Open Access Journals (Sweden)

    Safuanov F.S.

    2017-07-01

    Full Text Available Federal law of June 7, 2017 g. № 120-FZ "On amendments to the criminal code of the Russian Federation and article 151 of the Criminal procedure code of the Russian Federation in the part of establishing additional mechanisms to counter activities aimed at encouraging children to suicidal behavior" establishes criminal liability for inducement to commit suicide or assist in its Commission (article 110.1 of the criminal code, as well as for the organization of activities aimed at encouraging citizens to commit suicide (article 110.2 of the criminal code. Two additions to the criminal code include using a publicly performed work, the media or information and telecommunications networks (including network "Internet". There are new legal consequences relevant to forensic psychological assessment related to suicide. The article analyzes the legal situation (pre-investigation check of materials and incitement to suicide that define the subject of judicial-psychological or psychological and psychiatric examinations as the mental state of the subject in the period preceding the suicide (death. Legislative innovations require expertise in psychology and linguistics. One of the subjects of psychological-linguistic expertise is the focus of the information material (text, graphic, together verbal and non-verbal information or the communicative activity of the subject to encourage the addressee to co-concluding suicide. Formulate possible questions for the ex-experts and psychologists.

  15. The real aims of the USA and the EU in the Balkans

    Directory of Open Access Journals (Sweden)

    Čavoški Kosta S.

    2002-01-01

    Full Text Available The article explores the real aims of the so-called international community which is usually understood as the USA, as the only remaining super power and the European Union, particularly France. Great Britain and Germany. The author argues that the real and particularly long-term aims of these powers should be primarily inferred from their real deeds and only subsequently from public statements of their officials. By analyzing a number of examples in the Balkans and in other parts of the world the author comes to unexpected conclusions. While in words big Western powers supported multi-ethnicity and preservation of multi-ethnic states, in deeds they not only instigated nationalism and separatism but also hastened and recognized the dissolution of three European federations into 22 more or less national states. And while in words they apparently supported so-called democratization, in practice they not only supported authoritarian regimes but also identified democracy with occupation in Republika Srpska.

  16. Experiences of professionals participating in inter-organisational cooperation aimed at promoting clients' return to work.

    Science.gov (United States)

    Söderberg, Elsy; Vimarlund, Vivian; Alexanderson, Kristina

    2010-01-01

    In Sweden, the activities initiated to promote return to work (RTW) are performed in parallel by four different public organisations: the health services, the social services, the employment and the social insurance authorities. The aim was to gain deeper understanding on the experiences of professionals involved in cooperative projects aimed at promoting RTW among unemployed sickness benefit recipients. Qualitative analyses were performed of transcribed data from interviews of professionals participating in cooperative projects. First, the analysis identified that the daily collaboration on the same cases enabled development of good relationships and cooperative competence, which improved the contact with clients. Second, the cooperative projects made it possible to include only clients perceived motivated for RTW measures. Third, the closer and more frequent interaction with clients proved to be constructive in that it facilitated recognition and mobilisation of strengths and abilities. Fourth, the differences in rules and regulations between the social insurance and the unemployment insurance standards were often perceived to induce problems, for example, on how to assess the work capacity of clients. The assessments of work capacity represent important and complex tasks that professionals must perform without having access to either scientific knowledge or consensus agreement on which to base their decisions.

  17. P3a from white noise.

    Science.gov (United States)

    Frank, David W; Yee, Ryan B; Polich, John

    2012-08-01

    P3a and P3b event-related brain potentials (ERPs) were elicited with an auditory three-stimulus (target, distracter, and standard) discrimination task in which subjects responded only to the target. Distracter stimuli consisted of white noise or novel sounds with stimulus characteristics perceptually matched. Target/standard discrimination difficulty was manipulated by varying target/standard pitch differences to produce relatively easy, medium, and hard tasks. Error rate and response time increased with increases in task difficulty. P3a was larger for the white noise compared to novel sounds, maximum over the central/parietal recording sites, and did not differ in size across difficulty levels. P3b was unaffected by distracter type, decreased as task difficulty increased, and maximum over the parietal recording sites. The findings indicate that P3a from white noise is robust and should be useful for applied studies as it removes stimulus novelty variability. Theoretical perspectives are discussed. Copyright © 2012 Elsevier B.V. All rights reserved.

  18. An Economic Aspect of the AVOID Programme: Analysis Using the AIM/CGE Model

    Science.gov (United States)

    Matsumoto, Ken'ichi; Masui, Toshihiko

    2010-05-01

    This presentation purposes to show the results of the analysis that the AIM/CGE [Global] model contributed to Work Stream 1 of the AVOID programme. Three economic models participate in this WS to analyze the economic aspects of defined climate policies, and the AIM/CGE [Global] model is one of them. The reference scenario is SRES A1B and five policy scenarios (2016.R2.H, 2016.R4.L, 2016.R5.L, 2030.R2.H, and 2030.R5.L) are considered. The climate policies are expressed as emissions pathways of several gases such as greenhouse gases and aerosols. The AIM/CGE [Global] model is a recursive dynamic global CGE model with 21 industrial sectors and 24 world regions. These definitions are based on the GTAP6 database and it is used as the economic data of the base year. Some important characteristics of this model can be summarized as follows: power generation by various sources (from non-renewables to renewables) are considered; CCS technology is modeled; biomass energy (both traditional and purpose-grown) production and consumption are included; not only CO2 emissions but also other gases are considered; international markets are modeled for international trade of some fossil fuels; relationships between the costs and resource reserves of fossil fuels are modeled. The model is run with 10-year time steps until 2100. For the reference case, there are no constraints and the model is run based on the drivers (assumptions on GDP and population for A1B) and AEEI. The reference case does not have the same emissions pathways as the prescribed emissions for A1B in AVOID. For scenario cases, the model is run under emissions constraints. In particular, for each policy scenario, the constraint on each gas in each 10-year step is derived. The percentage reduction in emissions that occurs between the AVOID A1B scenario and the particular policy scenario, for each gas in each 10-year period is first calculated, and then these percentage reductions are applied to the AIM reference case

  19. Identifying vehicle descriptions in microblogging text with the aim of reducing or predicting crime

    CSIR Research Space (South Africa)

    Featherstone, Coral

    2013-11-01

    Full Text Available contain only about 12 words. While the standard smoothing techniques become essential under these circumstances[3], data mining techniques in the microblogging realm use additional techniques that are specific to this genre in order to supplement... can also refer to images or music or any other focus of the machine learning process. What is useful here is recognising that the text of one Tweet may not necessarily be the only document that we need to focus on. We can combine Tweets with other...

  20. Iodinated contrast media and patients with high-risk kidneys. Aiming at rational prevention

    International Nuclear Information System (INIS)

    Fontaine, B.; Frouge, C.; Gagey, N.

    1994-01-01

    Acute renal failure induced by iodinated contrast media (CM) accounts for about 10% of all hospital cases of renal failure, especially in azotemic patients. The specific anatomy and physiology of the inner medulla renalis render it particularly sensitive to even a moderate reduction in blood supply. Renal function will be estimated by measuring serum creatinine levels, before and within 72 hours after administration of the iodinated contrast medium. Hypovolaemia, diabetes mellitus-induced microangiopathy, nephrotoxic drugs and especially dehydratation may provoke renal accidents. Proper hydration, choosing a low osmolality medium and adequately spacing exposures to CM are elementary measures to be adopted to prevent renal failure. (authors)

  1. Genre-Specific Semantic Video Indexing

    NARCIS (Netherlands)

    Wu, J.; Worring, M.

    2010-01-01

    In many applications, we find large video collections from different genres where the user is often only interested in one or two specific video genres. So, when users are querying the system with a specific semantic concept, they are likely aiming a genre specific instantiation of this concept.

  2. Deletion of the Inflammasome Sensor Aim2 Mitigates Aβ Deposition and Microglial Activation but Increases Inflammatory Cytokine Expression in an Alzheimer Disease Mouse Model.

    Science.gov (United States)

    Wu, Pei-Jung; Hung, Yun-Fen; Liu, Hsin-Yu; Hsueh, Yi-Ping

    2017-01-01

    Inflammation is clearly associated with Alzheimer disease (AD). Knockout of Nlrp3, a gene encoding an inflammasome sensor, has been shown to ameliorate AD pathology in a mouse model. Because AIM2 is the most dominant inflammasome sensor expressed in mouse brains, here we investigate whether Aim2 deletion also influences the phenotype of a 5XFAD AD mouse model. Quantitative RT-PCR, immunostaining, immunoblotting, and behavioral analyses were applied to compare wild-type, Aim2-/-, 5XFAD, and Aim2-/-;5XFAD mice. We found that Aim2 knockout mitigates Aβ deposition in the cerebral cortex and hippocampus of 5XFAD mice. The activation of microglial cells is also reduced in Aim2-/-;5XFAD brains compared with 5XFAD brains. However, Aim2 knockout does not improve memory and anxiety phenotypes of 5XFAD mice in an open field, cued Y-maze, or Barnes maze. Compared with 5XFAD mice, Il-1 expression levels are not reduced in Aim2-/-;5XFAD mice. Unexpectedly, Il-6 and Il-18 expression levels in 5XFAD brains were further increased when Aim2 was deleted. Thus, inflammatory cytokine expression in 5XFAD brains is upregulated by Aim2 deletion through an unknown mechanism. Although Aim2 knockout mitigates Aβ deposition and microglial activation, Aim2 deletion does not have a beneficial effect on the spatial memory or cytokine expression of 5XFAD mice. Our findings suggest that Aβ aggregation and microglial activation may not always be correlated with the expression of inflammatory cytokines or cognitive function of 5XFAD mice. Our study also implies that different inflammasomes likely perform distinct roles in different physiological and/or pathological events. © 2017 S. Karger AG, Basel.

  3. Aiming at Excellence as Our Science Evolves Amidst the Bumpiness of Modern Academia

    Science.gov (United States)

    Furbish, D. J.

    2005-12-01

    The health and stature of an academic department are strongly influenced by how its vision and mission mesh with those of the college/school and university. Aiming at this alignment is a continuous process, as it typically involves engaging competing interests and disparate world views of all participants, and is punctuated by weighty, albeit academically normal, events with varying recurrence intervals. For example, the typical (35-year) career faculty member in the U.S. will, on average, see 8.8 department chair (re)appointments, experience 7.8 academic deans and 5.3 presidents/chancellors, be eligible for 5 sabbaticals, hear about if not undergo 3.5 NRC ranking processes, contribute to 1.8 curriculum revisions at the college/school level and to one major curriculum revision at the department level, participate in at least N - 1 faculty searches and at least 0.8N tenure reviews (where N is faculty size, assumed to be steady), and see about one full turnover of the department faculty. If affiliated with a program where securing external funding is expected, this typical academician will with luck participate, on average, in at least 11.7 external grants. These events are sources of both inertia and acceleration, stability and instability; they are triggers of change as well as tools of change. Moreover, geoscience departments in particular are facing the need to reexamine their missions in response to the rapidly evolving scope of our science -- within the context of institutional pressures driven by changing student interests, prioritization in allocation of resources, changes in emphasis on educational level, and changing societal expectations of education. No steady states exist. Strength comes in aiming at a vision centered on agreed-upon principles of excellence that possess long time constants, using shorter recurrence-interval events as tools for tuning to this vision. Important examples occur in curriculum development/revision, hiring and mentoring

  4. An integrated information system for the acquisition, management and sharing of environmental data aimed to decision making

    Science.gov (United States)

    La Loggia, Goffredo; Arnone, Elisa; Ciraolo, Giuseppe; Maltese, Antonino; Noto, Leonardo; Pernice, Umberto

    2012-09-01

    This paper reports the first results of the Project SESAMO - SistEma informativo integrato per l'acquisizione, geStione e condivisione di dati AMbientali per il supportO alle decisioni (Integrated Information System for the acquisition, management and sharing of environmental data aimed to decision making). The main aim of the project is to design and develop an integrated environmental information platform able to provide monitoring services for decision support, integrating data from different environmental monitoring systems (including WSN). This ICT platform, based on a service-oriented architecture (SOA), will be developed to coordinate a wide variety of data acquisition systems, based on heterogeneous technologies and communication protocols, providing different sort of environmental monitoring services. The implementation and validation of the SESAMO platform and its services will involve three specific environmental domains: 1) Urban water losses; 2) Early warning system for rainfall-induced landslides; 3) Precision irrigation planning. Services in the first domain are enabled by a low cost sensors network collecting and transmitting data, in order to allow the pipeline network managers to analyze pressure, velocity and discharge data for reducing water losses in an urban contest. This paper outlines the SESAMO functional and technological structure and then gives a concise description of the service design and development process for the second and third domain. Services in the second domain are enabled by a prototypal early warning system able to identify in near-real time high-risk zones of rainfall-induced landslides. Services in the third domain are aimed to optimize irrigation planning of vineyards depending on plant water stress.

  5. Rab3a-Bound CD63 Is Degraded and Rab3a-Free CD63 Is Incorporated into HIV-1 Particles

    Directory of Open Access Journals (Sweden)

    Yoshinao Kubo

    2017-08-01

    Full Text Available CD63, a member of the tetraspanin family, is involved in virion production by human immunodeficiency virus type 1 (HIV-1, but its mechanism is unknown. In this study, we showed that a small GTP-binding protein, Rab3a, interacts with CD63. When Rab3a was exogenously expressed, the amounts of CD63 decreased in cells. The Rab3a-mediated reduction of CD63 was suppressed by lysosomal and proteasomal inhibitors. The amount of CD63 was increased by reducing the endogenous Rab3a level using a specific shRNA. These results indicate that Rab3a binds to CD63 to induce the degradation of CD63. Rab3a is thought to be involved in exocytosis, but we found that another function of Rab3a affects the fate of CD63 in lysosomes. CD63 interacted with Rab3a and was incorporated into HIV-1 particles. However, Rab3a was not detected in HIV-1 virions, thereby indicating that Rab3a-free CD63, but not Rab3a-bound CD63, is incorporated into HIV-1 particles. Overexpression or silencing of Rab3a moderately reduced HIV-1 virion formation. Overexpression of Rab3a decreased CD63 levels, but did not affect the incorporation of CD63 into HIV-1 particles. This study showed that Rab3a binds to CD63 to induce the degradation of CD63, and only Rab3a-free CD63 is incorporated into HIV-1 particles.

  6. Preliminary analysis in a clayey mass aimed at ceramic blocks production: physical and mineralogical characteristics

    International Nuclear Information System (INIS)

    Silva, L.J.M.D. da; Apolonio, T.G.; Salviano, A.F.; Taveira, S.K.A.; Garcia, T.G.C.; Silva, J; Luna, P.A.; Macedo, R.S.

    2016-01-01

    The physical, chemical and mineralogical characterization of the clayey mass are important in determining its properties, allowing a better knowledge of the raw material used in the manufacture of ceramic products. This work aims to characterize the raw material used in the manufacture of ceramic sealing blocks in a ceramic industry. Thus, it was evaluated by laboratory tests the raw material used in the production of ceramic blocks in a ceramics industry in the region of Carnauba dos Dantas, RN. The methodology used in the tests is the same as the IPT, which consists in carrying out the plasticity testing, particle size, chemical analysis and X-ray diffraction. Results indicate that the sample studied by the physical and mineralogical characteristics, has the potential to be applied in the manufacture of red ceramic products for use in construction. (author)

  7. Survey of French research in biological and medical engineering - aims, means, results

    International Nuclear Information System (INIS)

    Teissier, J.

    1975-01-01

    A review of the aims and means available is followed by an outline of the results of French research in biological and medical engineering. Most of the work undertaken has given very positive results from the scientific view-point, followed up by industrial applications. Scintigraphic image processing research has led to CINE 200. A study of heart output quantification in real time has produced a haemodynamic investigation system, the Sysconoram, now commercialized. The study of heart signal recording methods has led to a marketable and reliable system for the detection of pathological heart conditions. Research in neurosurgery on the use of pressure transducers in integrated technology, using a piezoelectric detector associated with a field effect amplifier, has enabled two types of extradural pressure transducer and one cervical intraventricular pressure transducer to be industrialized. Finally the study of a gamma detector combined with a light-amplifier tube has led to the development of camera giving quite exceptional results [fr

  8. SALEIE: An EU project aiming to propose new EIE curricula oriented to key global technical challenges

    DEFF Research Database (Denmark)

    Poboroniuc, Marian-Silviu; Friesel, Anna; Livint, Gheorghe

    2014-01-01

    in European Higher Education Institutions) is one of its new EU projects which coagulate a global team aiming to provide higher education models in the EIE disciplines that can respond to the key global technical challenges. The SALEIE project's work package WP3 (Global Challenges) is related to: state......-of-the-art in implementation of the Bologna recommendation for Bachelor and Master, EIE connected technical, existing models in EIE higher education and their degree of response to key global technical challenges as well as some examples of curriculum models which see the day light during the SALEIE workshops......For the last two decades The European Association for Education in Electrical and Information Engineering (EAEEIE) has been dedicated and continue to support the Electrical and Information Engineering (EIE) education in Europe. SALEIE (Strategic Alignment of Electrical and Information Engineering...

  9. Geographic health information systems: a platform to support the 'triple aim'.

    Science.gov (United States)

    Miranda, Marie Lynn; Ferranti, Jeffrey; Strauss, Benjamin; Neelon, Brian; Califf, Robert M

    2013-09-01

    Despite the rapid growth of electronic health data, most data systems do not connect individual patient records to data sets from outside the health care delivery system. These isolated data systems cannot support efforts to recognize or address how the physical and environmental context of each patient influences health choices and health outcomes. In this article we describe how a geographic health information system in Durham, North Carolina, links health system and social and environmental data via shared geography to provide a multidimensional understanding of individual and community health status and vulnerabilities. Geographic health information systems can be useful in supporting the Institute for Healthcare Improvement's Triple Aim Initiative to improve the experience of care, improve the health of populations, and reduce per capita costs of health care. A geographic health information system can also provide a comprehensive information base for community health assessment and intervention for accountable care that includes the entire population of a geographic area.

  10. Teaching portfolios and a competence framework aimed to build faculty teaching competencies

    DEFF Research Database (Denmark)

    Dolin, Jens; Kobayashi, Sofie

    as a need for a common language and reference. Main barriers are scepticism towards the teaching portfolio for assessment of competencies, fear of extra work load, possible use as control measures, and fear that standards will narrow teaching development. In a research intensive university it is very......The University of Copenhagen has decided to introduce teaching portfolios and a competence framework as initiatives aimed to address the relatively low status of teaching compared to research. The two measures have been designed in a bottom-up process and are also backed by university leadership....... This paper analyses drivers and barriers in achieving successful implementation of the two initiatives through an organisational action research project. Main drivers are recognition for the need to increase the status of teaching and needs for tools and space for reflecting on one’s teaching, as well...

  11. Virtual Surgical Planning and Piezoelectric Surgery in Tumor Extirpative Surgery Aimed at Inferior Alveolar Nerve Preservation

    Directory of Open Access Journals (Sweden)

    Eric L. Chung

    2017-01-01

    Full Text Available A myriad of extirpative surgical protocols for the management of benign tumors of the jaws have been presented in the literature. Through significant advancements in computer-aided design and computer-aided manufacturing (CAD/CAM technology and surgical instrumentation, today surgeons have at their disposal robust technology-driven techniques that are aimed at improving surgical outcomes. Our goal is to investigate the benefits of implementing virtual surgical planning (VSP in conjunction with piezoelectric surgery (PES to ensure success while minimizing the risk of complications during extirpation of tumors of the mandible. This case report describes the successful extirpation of an ossifying fibroma of the mandible in an adult patient using both VSP and PES.

  12. Enabling professionals to change practices aimed at tackling social inequality through professional development

    DEFF Research Database (Denmark)

    Jensen, Bente; Brandi, Ulrik

    2018-01-01

    Research has shown the potential for early childhood education and care (ECEC) in making a difference for all children. However, research also highlights how hard overcoming the ‘gaps’ between children from differing social backgrounds still is. The overall aim of this article is to examine the i...... inequality. The study emphasises that practices are enhanced through professional development that makes sense for participants, is organised in communities of practices (CoP) and communities of innovation (CoI), and is facilitated and integrated in entire ECEC systems...... conditions and well-being of all children, and socially disadvantaged children in particular. The overall argument is that co-construction as well as openness and reflection in the ECEC field is needed when professionals are to change their pedagogical practices towards tackling the issues of social...

  13. Process evaluation of a workplace health promotion intervention aimed at improving work engagement and energy balance.

    Science.gov (United States)

    van Berkel, Jantien; Boot, Cécile R L; Proper, Karin I; Bongers, Paulien M; van der Beek, Allard J

    2013-01-01

    To evaluate the process of the implementation of an intervention aimed at improving work engagement and energy balance, and to explore associations between process measures and compliance. Process measures were assessed using a combination of quantitative and qualitative methods. The mindfulness training was attended at least once by 81.3% of subjects, and 54.5% were highly compliant. With regard to e-coaching and homework exercises, 6.3% and 8.0%, respectively, were highly compliant. The training was appreciated with a 7.5 score and e-coaching with a 6.8 score. Appreciation of training and e-coaching, satisfaction with trainer and coach, and practical facilitation were significantly associated with compliance. The intervention was implemented well on the level of the mindfulness training, but poorly on the level of e-coaching and homework time investment. To increase compliance, attention should be paid to satisfaction and trainer-participant relationship.

  14. Geophysical survey aimed at selecting the radioactive waste repository site (Czech republic

    Directory of Open Access Journals (Sweden)

    Dušan Dostál

    2007-01-01

    Full Text Available G IMPULS Praha has been executing a set of geophysical measurements for the Radioactive Waste Repository Authority of the Czech Republic from 2001 (the work continues to be carried out. The measurements are aimed at studying the behaviour of the rock massif, focusing on the Excavation Damaged or Disturbed Zone (EDZ and on selecting an appropriate area for the radioactive material repository site. The geophysical studies use a complex of methods as follows: Airborne geophysical measurement (regional studies, Seismic measurement (detailed studies, G.P.R. (detailed studies, Resistivity tomography (detailed studies, Geoelectric measurement and magnetic survey (stray earth currents. The paper informs about first results and conclusions. The airborne work was executed as a part of the complex study of „GEOBARIERA“ the group and the geophysical measurements of EDZ were executed in co-operation with the Czech Geological Survey.

  15. The Economic Discourse of the Current Reform Aimed at Business Optimization in Ukraine

    Directory of Open Access Journals (Sweden)

    Purdenko Olena A.

    2016-05-01

    Full Text Available The aim of the article is to study the strengths and weaknesses of the current reforms and provide appropriate recommendations and proposals to improve the regulatory and economic business environment. The article analyzes the introduced reforms in the aspect of the regulatory field and the active current system of taxation with the detailing of the type and content of the basic implemented measures. There have been justified the advantages and disadvantages of the introduced system of taxation with respect to the main budget forming taxes, such as the enterprise income taxes, value added tax, individual income tax considering changes in the administering of unified social tax (UST and war tax, excise duty. On the basis of the results of the study it has been found that the introduced reforms only partially improved the tax administration system and in no way reduced the announced tax burden, the time spending of business for preparing the current report was not significantly reduced.

  16. Nozzle Fuzzy Controller of Agricultural Spraying Robot Aiming Toward Crop Rows

    Science.gov (United States)

    Ren, Jianqiang

    A novel nozzle controller of spraying robot aiming toward crop-rows based on fuzzy control theory was studied in this paper to solve the shortcomings of existing nozzle control system, such as the long regulation time, the higher overshoot and so on. The new fuzzy controller mainly consists of fuzzification interface, defuzzification interface, rule-base and inference mechanism. Considering the actual application, the fuzzy controller was designed as a 2-inputs&1-output closed-loop system. The inputs are the distance from nozzle to crop row and its change rate, the output is the control signal to the execution unit. Based on the design project, we selected the FMC chip NLX230, the EMCU chip AT89S52 and the EEPROM chip AT93C57 to make the fuzzy controller. Experimental results show that the project is workable and efficient, it can solve the shortcomings of existing controller perfectly and the control efficiency can be improved greatly.

  17. School outcomes of a community-wide intervention model aimed at preventing problem behavior.

    Science.gov (United States)

    Kjøbli, John; Sørlie, Mari-Anne

    2008-08-01

    The Early Intervention for Children at Risk for Developing Behavioral Problems (EICR) is a community-wide intervention model preventing and treating problem behavior and promoting social competence in children. The aim of the study was to test whether EICR would result in fewer incidences of problem behavior and improved learning climate in elementary schools in a Norwegian municipality. The municipality was divided in two, each section having equal chance of being assigned to the intervention condition. Participants were principals and school staff. One year after the initiation of EICR, the prevalence of student problem behavior was significantly lower, and student relations were significantly better for schools located in the intervention area than for schools located in the comparison area. The findings support further development, implementation and research on the EICR model.

  18. Aims and scope of the Netherlands HDP Committee. On the threshold of the third millennium

    International Nuclear Information System (INIS)

    1999-02-01

    The Netherlands HDP Committee aims to promote and co-ordinate research on the human dimensions of global environmental change. Its main objective is to stimulate Dutch social scientists to participate in national and international global change research and to facilitate contacts between these researchers and potential funding agencies. The Committee is developing several strategic activities to bridge the gap between the Netherlands social science research community and the Science Projects that have been identified within the context of the International Human Dimensions Programme on Global Environmental Change (IHDP). The Science Projects covered include Industrial Transformation (IT), Global Environmental Change and Human Security (GECHS), Institutional Dimensions of Global Environmental Change (IDGEC) and Land Use and Land Cover (LUCC) respectively

  19. RECYCLING OF PRINTED CIRCUIT BOARDS AIMING SILVER RECOVERY: A HYDROMETALLURGICAL ROUTE STUDY

    Directory of Open Access Journals (Sweden)

    Marcos Paulo Kohler Caldas

    2015-06-01

    Full Text Available The aim of this paper is characterize printed circuit board of computers and propose a hydrometallurgical route for silver recovery present in its composition. Initially, the printed circuit board was comminuted in both knife and hammer mills. The comminuted material was characterized by sieve analysis, chemical analysis by inductively coupled plasma optical emission spectrometry (ICP-OES and loss on ignition. Leaching tests were conducted in sulfuric acid, sulfuric acid in an oxidizing medium and nitric acid. The results indicated that the printed circuit board is mainly composed of copper (19.42%. Silver content of 0.045% was found. The route for silver recovery was leaching in sulfuric acid at 75°C for 18 hours. Then, leaching in sulfuric acid at 75°C in an oxidizing medium for 6 hours and nitric acid leaching at room temperature for 2 hours. Through of this route, 96.6% of silver was recovered.

  20. Calculation of multiplication factors regarding criticality aiming at the storage of fissile material

    International Nuclear Information System (INIS)

    Lima Barros, M. de.

    1982-04-01

    The multiplication factors of several systems with low enrichment, 3,5% and 3,2% in the isotope 235 U, aiming at the storage of fuel of ANGRA-I and ANGRA II, through the method of Monte Carlo, by the computacional code KENO-IV and the library of section of cross Hansen - Roach with 16 groups of energy. The method of Monte Carlo is specially suitable to the calculation of the factor of multiplication, because it is one of the most acurate models of solution and allows the description of complex tridimensional systems. Various tests of sensibility of this method have been done in order to present the most convenient way of working with KENO-IV code. The safety on criticality of stores of fissile material of the 'Fabrica de Elementos Combustiveis ', has been analyzed through the method of Monte Carlo. (Author) [pt

  1. A reduction clamp for an aiming component in associated acetabular fractures

    Directory of Open Access Journals (Sweden)

    Zhang-Fu Wang

    2015-01-01

    Full Text Available Background: The treatment of acetabular fractures is complex and requires specialized equipment. However, all currently available instruments have some disadvantages. A new reduction clamp that can firmly enable reduction and not hinder subsequent fixation procedures for some special fracture types is needed. Materials and Methods: In this study, we introduce a new acetabular clamp and its preliminary clinical application in three T-shaped acetabular fractures. Results: This new clamp can successfully pull the posterior column back to the anterior column and firmly maintain the reduction. This clamp′s aiming plate can facilitate the insertion of long lag screws. The clamp is also easy to assemble and use. Conclusion: This reduction clamp is a useful instrument that can facilitate open reduction and internal fixation of acetabular fractures.

  2. STRATEGIC DECISION MAKING IN THE MANAGEMENT OF PROJECTS, AIMED AT THE BIM

    Directory of Open Access Journals (Sweden)

    Burneo Valarezo Servio

    2016-12-01

    Full Text Available Decision making in the management of projects aimed at Building Information Modeling, represents the main action to be developed during the development of the investment lifecycle, from inception to the development of life, decision marking is present in all phases of project management. In the Fund's shares of the production system by projects, decision making integrated from the priorities of the projects play an important role in the success of the company. The present work has as objective the development of a procedure for decision making during the life cycle of the project, the conditions for its implementation and the process for its development, with the purpose of raising their quality, to ensure decision making effective, consistent with the current development of the techniques of management.

  3. Control of nuclear energy: new aims for the reform of international institutions

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, B.

    1977-12-01

    Detailed negotiations over a possible package of measures to reform international safeguards and security managements under which nuclear technology is transferred are going on behind closed doors in the ''London Club,'' or Nuclear Suppliers' Group. The talks appear to be chiefly concentrated on bilateral agreements over national measures of control. The author examines some possible aims and functions that seem reasonable targets for negotiated reform over the coming months. These would include: jointly guaranteed supplies of low-enriched uranium for thermal reactors; a new international safeguards system; international nuclear security and safety standards; international agreement on nuclear waste disposal measures; international institutional initiative to promote alternative energy sources; functional reform of the IAEA; and reorganized regulatory review processes at national levels. (MCW)

  4. Computational study of formamide-water complexes using the SAPT and AIM methods

    International Nuclear Information System (INIS)

    Parreira, Renato L.T.; Valdes, Haydee; Galembeck, Sergio E.

    2006-01-01

    In this work, the complexes formed between formamide and water were studied by means of the SAPT and AIM methods. Complexation leads to significant alterations in the geometries and electronic structure of formamide. Intermolecular interactions in the complexes are intense, especially in the cases where the solvent interacts with the carbonyl and amide groups simultaneously. In the transition states, the interaction between the water molecule and the lone pair on the amide nitrogen is also important. In all the complexes studied herein, the electrostatic interactions between formamide and water are the main attractive force, and their contribution may be five times as large as the corresponding contribution from dispersion, and twice as large as the contribution from induction. However, an increase in the resonance of planar formamide with the successive addition of water molecules may suggest that the hydrogen bonds taking place between formamide and water have some covalent character

  5. New missions aim to make a short list of exo-Earths

    Science.gov (United States)

    Clery, Daniel

    2018-03-01

    Thanks to NASA's pioneering Kepler probe, we know our galaxy is teeming with exoplanets. Now, a new generation of exoplanet hunters is set to home in on rocky worlds closer to home. Over 9 years in space, Kepler has found more than 2600 confirmed exoplanets. The new efforts sacrifice sheer numbers and target Earth-size planets whose composition, atmosphere, and climate—factors in whether they might be hospitable to life—could be probed. Leading the charge is the Transiting Exoplanet Survey Satellite (TESS), a NASA mission due for launch on 16 April. The $337 million TESS project aims to identify at least 50 rocky exoplanets—Earth-size or bigger—close enough for their atmospheres to be scrutinized by the much larger James Webb Space Telescope, due for launch in 2020.

  6. PEDAGOGICAL TECHNOLOGY AIMED AT STUDENTS’ ADAPTATION TO DISCIPLINE-BASED EDUCATION IN SECONDARY SCHOOLS

    Directory of Open Access Journals (Sweden)

    Ekaterina M. Cheprakova

    2015-01-01

    Full Text Available The aim of the study is to describe the educational technology aimed at students adaptation to discipline-based education in basic school; results discussion of the application practice to the educational process of the 5th grade.Methods. The methods involve learning experience, school documentation analysis, pedagogical experiment, study of students’ creativity and pedagogical experience on its organizational work. Systematic approach is used while structuring of the 5th grade students’ representations on the disciplines’ content of primary and basic general education on the methodological levelResults. The pedagogical technology of breaking the students’ educational disadaptation in the basic school is presented. The program of the course «All the subjects are good» is worked out. This program may allow students to adapt to the discipline content of the general education, to understand the essence of curriculum disciplines content and links between them, and the motivation development towards disciplinebased education evidence students’ adaptation. These objectives can be achieved through generation of skills based on the algorithmic of the concepts’ definitions mastering. The pilot implementation of the proposed technology in secondary school № 65 and in the Center «Giftedness and technology» of Yekaterinburg is presented.Scientific novelty. The effective way of neutralization and elimination of students’ discipline-educational disadaptation based on purposeful development of their conceptual thinking is proposed.Practical significance. The technology developed by authors allows teachers to form and develop the universal educational actions representing itself as a result of school training in the requirements of the educational standard. Timely use of this technology at transition age of children from primary school to secondary one provides the further success of their education.

  7. Investigation of individuals going to coffeehouse with the aim of leisure time activities

    Directory of Open Access Journals (Sweden)

    Hüseyin ÖZTÜRK

    2015-08-01

    Full Text Available The main basis of this research is to investigate pe ople going to coffeehouse with the aim of leisure time activities. The research group of this study consist of individuals going to the coffeehouses with the aim of leisure time activities in the city of Gaz iantep, Turkey. A total of 421 individuals joined to the research voluntarily. The Research consists of two parts. In the first part, personal information was used. In the second part, the leisure questionnaire form developed by Binarbaşı (2006 was u sed in order to determine individuals’ leisure time habits. The statistical programme SPSS 16.0 software packed programme was used to analyze the data. While analyzing the data, descriptive statistics methods were used as frequency percentage so P <0.05 was considered statistically significant. As the result of research; it is seen that 41 years of age and older people prefer going to coffehouses more than the others, the big majority of them are elementary and junior high school graduates and mostly they are married people, mostly they have 1 - 2 children, as a profession they are mostly workers who take minimum wage and they work very little over salary as monthly income. People going to the coffeehouses in their free time preffered at a high rate that they mostly go to the coffeehouses to spend time with their friends, they are happy with this activity, in the same time they find it very relaxing and they mostly watch TV when they don’t go to coffeehouses in their spare time and they in dicated the reason for failure to participate in other activities except coffeehouses as the absence of relevant activities and programmes appealing to them and economic handicap.

  8. Universal power law of the gravity wave manifestation in the AIM CIPS polar mesospheric cloud images

    Directory of Open Access Journals (Sweden)

    P. Rong

    2018-01-01

    Full Text Available We aim to extract a universal law that governs the gravity wave manifestation in polar mesospheric clouds (PMCs. Gravity wave morphology and the clarity level of display vary throughout the wave population manifested by the PMC albedo data. Higher clarity refers to more distinct exhibition of the features, which often correspond to larger variances and a better-organized nature. A gravity wave tracking algorithm based on the continuous Morlet wavelet transform is applied to the PMC albedo data at 83 km altitude taken by the Aeronomy of Ice in the Mesosphere (AIM Cloud Imaging and Particle Size (CIPS instrument to obtain a large ensemble of the gravity wave detections. The horizontal wavelengths in the range of  ∼ 20–60 km are the focus of the study. It shows that the albedo (wave power statistically increases as the background gets brighter. We resample the wave detections to conform to a normal distribution to examine the wave morphology and display clarity beyond the cloud brightness impact. Sample cases are selected at the two tails and the peak of the normal distribution to represent the full set of wave detections. For these cases the albedo power spectra follow exponential decay toward smaller scales. The high-albedo-power category has the most rapid decay (i.e., exponent  =  −3.2 and corresponds to the most distinct wave display. The wave display becomes increasingly blurrier for the medium- and low-power categories, which hold the monotonically decreasing spectral exponents of −2.9 and −2.5, respectively. The majority of waves are straight waves whose clarity levels can collapse between the different brightness levels, but in the brighter background the wave signatures seem to exhibit mildly turbulent-like behavior.

  9. Sequencing biological acidification of waste-activated sludge aiming to optimize phosphorus dissolution and recovery.

    Science.gov (United States)

    Guilayn, Felipe; Braak, Etienne; Piveteau, Simon; Daumer, Marie-Line

    2017-06-01

    Phosphorus (P) recovery in wastewater treatment plants (WWTP) as pure crystals such as struvite (MgNH 4 PO 4 .6H 2 O), potassium struvite (KMgPO 4 .6H 2 O) and calcium phosphates (e.g. Ca 3 (PO 4 ) 2 ) is an already feasible technique that permits the production of green and marketable fertilizers and the reduction of operational costs. Commercial crystallizers can recovery more than 90% of soluble P. However, most of the P in WWTP sludge is unavailable for the processes (not dissolved). P solubilization and separation are thus the limiting steps in P-crystallization. With an innovative two-step sequencing acidification strategy, the current study has aimed to improve biological P solubilization on waste-activated sludge (WAS) from a full-scale plant. In the first step (P-release), low charges of organic waste were used as co-substrates of WAS pre-fermentation, seeking to produce volatile fatty acids to feed the P-release by Polyphosphate-accumulating organisms, while keeping its optimal metabolic pH (6-7). In this phase, milk serum, WWTP grease, urban organic waste and collective restaurant waste were individually applied as co-substrates. In the second step (P-dissolution), pH 4 was aimed at as it allows the dissolution of the most common precipitated species of P. Biological acidification was performed by white sugar addition, as a carbohydrate-rich organic waste model, which was compared to chemical acidification by HCl (12M) addition. With short retention times (48-96 h) and without inoculum application, all experiences succeeded on P solubilization (37-55% of soluble P), principally when carbohydrate-rich co-substrates were applied. Concentrations from 270 to 450 mg [Formula: see text] were achieved. [Formula: see text].

  10. Universal power law of the gravity wave manifestation in the AIM CIPS polar mesospheric cloud images

    Science.gov (United States)

    Rong, Pingping; Yue, Jia; Russell, James M., III; Siskind, David E.; Randall, Cora E.

    2018-01-01

    We aim to extract a universal law that governs the gravity wave manifestation in polar mesospheric clouds (PMCs). Gravity wave morphology and the clarity level of display vary throughout the wave population manifested by the PMC albedo data. Higher clarity refers to more distinct exhibition of the features, which often correspond to larger variances and a better-organized nature. A gravity wave tracking algorithm based on the continuous Morlet wavelet transform is applied to the PMC albedo data at 83 km altitude taken by the Aeronomy of Ice in the Mesosphere (AIM) Cloud Imaging and Particle Size (CIPS) instrument to obtain a large ensemble of the gravity wave detections. The horizontal wavelengths in the range of ˜ 20-60 km are the focus of the study. It shows that the albedo (wave) power statistically increases as the background gets brighter. We resample the wave detections to conform to a normal distribution to examine the wave morphology and display clarity beyond the cloud brightness impact. Sample cases are selected at the two tails and the peak of the normal distribution to represent the full set of wave detections. For these cases the albedo power spectra follow exponential decay toward smaller scales. The high-albedo-power category has the most rapid decay (i.e., exponent = -3.2) and corresponds to the most distinct wave display. The wave display becomes increasingly blurrier for the medium- and low-power categories, which hold the monotonically decreasing spectral exponents of -2.9 and -2.5, respectively. The majority of waves are straight waves whose clarity levels can collapse between the different brightness levels, but in the brighter background the wave signatures seem to exhibit mildly turbulent-like behavior.

  11. Cost-effectiveness of policies aimed at increasing organ donation: the case of Chile.

    Science.gov (United States)

    Domínguez, J; Harrison, R; Atal, R; Larraín, L

    2013-01-01

    In this article we present an economic evaluation of policies aimed at increasing deceased organ donation in Chile, a developing country that has low donation rates; it had 5.4 donors per million people (pmp) in 2010. Expert opinions of leading participants in donation and transplantation were analyzed, resulting in a set of local policies aimed at increasing donation rates. Using previous results of reported cost savings of increasing kidney transplantation in Chile, we estimated the net benefits of these policies, as a function of additional donors. The main problem of the Chilean system seems to be the low capability to identify potential donors and a deficit in intensive care unit (ICU) beds. Among considered policies central to increase donation are the following: increasing human and capital resources dedicated to identifying potential donors, providing ICU beds from private centers, and developing an online information system that facilitates procurement coordination and the evaluation of performance at each hospital. Our results show that there is a linear relationship between cost savings and incremental donors pmp. For example, if these policies are capable of elevating donation rates in Chile by 6 donors pmp net estimated cost savings are approximately US $1.9 million. Likewise, considering the effect on patients' quality of life, savings would amount to around $15.0 million dollars per year. Our estimates suggest that these policies have a large cost-saving potential. In fact, considering implementation costs, cost reduction is positive after 4 additional donors pmp, and increasing afterward. Copyright © 2013 Elsevier Inc. All rights reserved.

  12. Mobile Phone App Aimed at Improving Iron Intake and Bioavailability in Premenopausal Women: A Qualitative Evaluation

    Science.gov (United States)

    Riddell, Lynn; Lim, Karen; Byrne, Linda K; Nowson, Caryl; Rigo, Manuela; Szymlek-Gay, Ewa A; Booth, Alison O

    2015-01-01

    Background Low iron intake can lead to iron deficiency, which can result in impaired health and iron-deficiency anemia. A mobile phone app, combining successful dietary strategies to increase bioavailable iron with strategies for behavior change, such as goal setting, monitoring, feedback, and resources for knowledge acquisition, was developed with the aim to increase bioavailable iron intake in premenopausal women. Objective To evaluate the content, usability, and acceptability of a mobile phone app designed to improve intake of bioavailable dietary iron. Methods Women aged 18-50 years with an Android mobile phone were invited to participate. Over a 2-week period women were asked to interact with the app. Following this period, semistructured focus groups with participants were conducted. Focus groups were audio recorded and analyzed via an inductive open-coding method using the qualitative analysis software NVivo 10. Themes were identified and frequency of code occurrence was calculated. Results Four focus groups (n=26) were conducted (age range 19-36 years, mean 24.7, SD 5.2). Two themes about the app’s functionality were identified (frequency of occurrence in brackets): interface and design (134) and usability (86). Four themes about the app’s components were identified: goal tracker (121), facts (78), photo diary (40), and games (46). A number of suggestions to improve the interface and design of the app were provided and will inform the ongoing development of the app. Conclusions This research indicates that participants are interested in iron and their health and are willing to use an app utilizing behavior change strategies to increase intake of bioavailable iron. The inclusion of information about the link between diet and health, monitoring and tracking of the achievement of dietary goals, and weekly reviews of goals were also seen as valuable components of the app and should be considered in mobile health apps aimed at adult women. PMID:26416479

  13. The evaluation of a mass media campaign aimed at weight gain prevention among young Dutch adults.

    Science.gov (United States)

    Wammes, Birgitte; Oenema, Anke; Brug, Johannes

    2007-11-01

    The objective was to evaluate a 3-year nationwide mass media campaign aimed at preventing weight gain. The campaign was aimed primarily at raising awareness of the importance of weight-gain prevention and bringing these issues to the attention of the Dutch public. Eleven serial, independent, cross-sectional, population-based telephone surveys were used to assess campaign awareness and impact (N ranged between 483 and 493 for each of the 11 surveys). The surveys were conducted before and after six campaign waves. Multiple linear and logistic regression analyses were used to test for trends over time and for differences among the surveys for campaign awareness, message recall, perceived body weight status, overweight-related risk perceptions, attitudes, perceived social support, self-efficacy expectations, and motivations for preventing weight gain. Campaign awareness ranged from 61% after the 1st campaign wave to 88.4% after the final wave. The campaign's television broadcasting activities were an important source of campaign awareness, from both the campaign's television commercials and television-based free publicity. Message recall ranged from 41.9% to 68.1%. Small positive differences were found in attitudes, perceived social support, and intentions for preventing weight gain. Additionally, the results suggest mixed effects on self-efficacy expectations and a negative effect on risk perception. The campaign resulted in high campaign awareness, especially as a result of television commercials and free publicity on television. The results suggest that the campaign was able to create more positive attitudes and motivation but lower risk perceptions and efficacy for preventing weight gain.

  14. Tau, Amyloid Beta and Deep Brain Stimulation: Aiming to Restore Cognitive Deficit in Alzheimer's Disease.

    Science.gov (United States)

    Mondragón-Rodríguez, Siddhartha; Perry, George; Pena-Ortega, Fernando; Williams, Sylvain

    2017-01-01

    The last two decades have seen a great advance in the data that supports the two current hypotheses in Alzheimer`s disease field, the amyloid beta hypothesis and the tau hypothesis. Not surprisingly, Aβ and tau proteins are currently the major therapeutic research targets for AD treatment. Unfortunately, nothing but moderate success has emerged from such therapeutic approaches. With this in mind, we will discuss deep brain stimulation as a promising therapeutic strategy that aims to restore brain activity. Lastly, in the scope of cognitive deficit restoration, we will discuss the relevance of the limbic formation as a promising neuroanatomical target for deep brain stimulation. Immunohistochemistry for modified tau (phosphorylated at Ser199-202-Thr205 labelled by the antibody AT8) was performed on paraffin-embedded human brain sections providing a detailed characterization of NFT pathology. Abnormally phosphorylated tau protein is the key common marker in several brain diseases such as Alzheimer's disease, Parkinson`s disease, Pick Disease, Down syndrome and frontotemporal dementia and is capable of affecting synaptic events that are critical for memory formation. With this in mind, therapeutic strategies aiming to restore synaptic events could offer better outcomes. The humble success of current therapeutic strategies along with the lack of basic knowledge of the brain disease mechanisms calls for alternatives that benefit patients in the present moment. One of particular interest is the neurostimulation strategy that is already a well-established treatment for several movement disorders and when compared to current Alzheimer`s therapeutic strategies, deep brain stimulation does not directly interfere with the normal protein function, therefore increasing the probability of success.

  15. Mobile Phone App Aimed at Improving Iron Intake and Bioavailability in Premenopausal Women: A Qualitative Evaluation.

    Science.gov (United States)

    Mann, Davina; Riddell, Lynn; Lim, Karen; Byrne, Linda K; Nowson, Caryl; Rigo, Manuela; Szymlek-Gay, Ewa A; Booth, Alison O

    2015-09-28

    Low iron intake can lead to iron deficiency, which can result in impaired health and iron-deficiency anemia. A mobile phone app, combining successful dietary strategies to increase bioavailable iron with strategies for behavior change, such as goal setting, monitoring, feedback, and resources for knowledge acquisition, was developed with the aim to increase bioavailable iron intake in premenopausal women. To evaluate the content, usability, and acceptability of a mobile phone app designed to improve intake of bioavailable dietary iron. Women aged 18-50 years with an Android mobile phone were invited to participate. Over a 2-week period women were asked to interact with the app. Following this period, semistructured focus groups with participants were conducted. Focus groups were audio recorded and analyzed via an inductive open-coding method using the qualitative analysis software NVivo 10. Themes were identified and frequency of code occurrence was calculated. Four focus groups (n=26) were conducted (age range 19-36 years, mean 24.7, SD 5.2). Two themes about the app's functionality were identified (frequency of occurrence in brackets): interface and design (134) and usability (86). Four themes about the app's components were identified: goal tracker (121), facts (78), photo diary (40), and games (46). A number of suggestions to improve the interface and design of the app were provided and will inform the ongoing development of the app. This research indicates that participants are interested in iron and their health and are willing to use an app utilizing behavior change strategies to increase intake of bioavailable iron. The inclusion of information about the link between diet and health, monitoring and tracking of the achievement of dietary goals, and weekly reviews of goals were also seen as valuable components of the app and should be considered in mobile health apps aimed at adult women.

  16. Genetic analysis of drug metabolizing phase-I enzymes CYP3A4 in ...

    Indian Academy of Sciences (India)

    The enzymatic activity of CYP3A4 results in broad interindividual variability in response to certain pharmacotherapies. The present study aimed to screen Tibetan volunteers for CYP3A4 genetic polymorphisms. Previous research has focussed on Han Chinese patients, while little is known about the genetic variation of ...

  17. Association of CYP3A4 and CYP3A5 polymorphisms with Iranian ...

    African Journals Online (AJOL)

    Elham Badavi

    2015-04-20

    Apr 20, 2015 ... Breast cancer;. CYP3A4;. CYP3A5;. Polymorphism;. Iranian population. Abstract Background: Polymorphisms of different gene have been reported to be associated with cancer including ... liver, small intestine jejunum, colon, breast, prostate and pancreas ..... This study is a Pharm D thesis. This work was ...

  18. Draft resolution aimed at creating an inquiry commission related to the EPR sector - Nr 1251

    International Nuclear Information System (INIS)

    Baupin, Denis; Pompili, Barbara; Rugy, Francois De; Abeille, Laurence; Alauzet, Eric; Allain, Brigitte; Attard, Isabelle; Auroi, Danielle; Bonneton, Michele; Cavard, Christophe; Coronado, Sergio; Lambert, Francois-Michel; Mamere, Noel; Massonneau, Veronique; Molac, Paul; Roumegas, Jean-Louis; Sas, Eva

    2013-01-01

    This draft resolution is based on several problems and issues raised by the construction of the EPR reactor in Flamanville and dealing with the perspectives for this specific sector. The authors outline that the construction may finally take almost twice as long as initially foreseen, that the budget has been multiplied by two and a half, that the safety of this installation is still a matter of questions (notably for the control-command system, for the resistance to a plane crash, and with respect with lessons learned from the Fukushima accident), and that the involved partners (GDF Suez, ENEL, Centrica, Siemens) are becoming always more hesitant. They evoke the problems faced by other EPRs under construction in Finland and in China, and state that export perspectives seem to lead to a failure. The draft resolution proposes the creation of an inquiry commission to examine these issues

  19. Chemical characterization of agroforestry solid residues aiming its utilization as adsorbents for metals in water

    Directory of Open Access Journals (Sweden)

    Francisco H. M. Luzardo

    2015-01-01

    Full Text Available In this work, a study of the correlation between the functional groups present in the chemical structure of the fibers of coconut shells, cocoa and eucalyptus, and their adsorption capacity of Cd+2 and Cu+2 ions from water was performed. The content of soluble solids and reactive phenols in aqueous extracts were determined. The chemical functional groups present in the fibers were examined using the IR spectra. The adsorption capacity of the peels was determined using atomic absorption spectrophotometer. For Cd+2, a significant correlation between the adsorption capacity and some specific chemical functional groups present in the fiber was verified. The potential use of these peels, as adsorbent of Cd+2 ions, is based on the presence of OH functional groups such as aryl-OH, aryl-O-CH2 of phenol carboxylic acids, as well as carbonyl groups derived from carboxylic acid salts, in these fibers.

  20. Antiviral Information Management System (AIMS): a prototype for operational innovation in drug development.

    Science.gov (United States)

    Jadhav, Pravin R; Neal, Lauren; Florian, Jeff; Chen, Ying; Naeger, Lisa; Robertson, Sarah; Soon, Guoxing; Birnkrant, Debra

    2010-09-01

    This article presents a prototype for an operational innovation in knowledge management (KM). These operational innovations are geared toward managing knowledge efficiently and accessing all available information by embracing advances in bioinformatics and allied fields. The specific components of the proposed KM system are (1) a database to archive hepatitis C virus (HCV) treatment data in a structured format and retrieve information in a query-capable manner and (2) an automated analysis tool to inform trial design elements for HCV drug development. The proposed framework is intended to benefit drug development by increasing efficiency of dose selection and improving the consistency of advice from US Food and Drug Administration (FDA). It is also hoped that the framework will encourage collaboration among FDA, industry, and academic scientists to guide the HCV drug development process using model-based quantitative analysis techniques.

  1. Thermal and physiochemical properties of pellets with power aims made of sawmill residual product

    International Nuclear Information System (INIS)

    Casanova Treto, Pedro; Solis, Kattia; Carrillo, Tonny

    2017-01-01

    Sawmill residual product of Pylon (Hyeronima alchorneoides) and Eucalyptus (Eucalyptus spp) species was used to produce pellets under different conditions of densification. Experimental equipment was used to determine the thermal conductivity, thermal diffusivity and specific heat. Physicochemical properties of the pellets obtained under different conditions of densification, such as ash content and calorific value were determined. The content of nitrogen, chlorine and sulfur present in the material used to produce the pellets was estimated. Thermal conductivity values were determined between 0,253 W/m·K and 0,279 W/m·K; 1,748 m2 /s and 2,314 m2 /s for the thermal diffusivity, and in the case of specific heat were determined values between 3,019 kJ/kg·K and 2,183 kJ/kg·K. The high heat values was between 18 907 kJ/kg and 18 960 kJ/kg. An ash content of 1,31% was determined on a dry basis. Finally, the content of nitrogen, chlorine and sulfur determined in the residual biomass used, corresponds to 0,1129%, 0,0592 % and 0,0317%, respectively. A direct relationship between increasing the bulk density of the pellets and the thermal properties was determined. The calorific value and the ash content had a negligible effect due to the treatments applied. The estimated content of N, Cl and S corresponds to that expected in the selected biomass. Comparison of the properties of the pellets produced under the conditions studied -densification, against regulations-, showed acceptable results, entering these in terms of different categories of quality. (author) [es

  2. Oral Health Care Reform in Finland – aiming to reduce inequity in care provision

    Directory of Open Access Journals (Sweden)

    Widström Eeva

    2008-01-01

    Full Text Available Abstract Background In Finland, dental services are provided by a public (PDS and a private sector. In the past, children, young adults and special needs groups were entitled to care and treatment from the public dental services (PDS. A major reform in 2001 – 2002 opened the PDS and extended subsidies for private dental services to all adults. It aimed to increase equity by improving adults' access to oral health care and reducing cost barriers. The aim of this study was to assess the impacts of the reform on the utilization of publicly funded and private dental services, numbers and distribution of personnel and costs in 2000 and in 2004, before and after the oral health care reform. An evaluation was made of how the health political goals of the reform: integrating oral health care into general health care, improving adults' access to care and lowering cost barriers had been fulfilled during the study period. Methods National registers were used as data sources for the study. Use of dental services, personnel resources and costs in 2000 (before the reform and in 2004 (after the reform were compared. Results In 2000, when access to publicly subsidised dental services was restricted to those born in 1956 or later, every third adult used the PDS or subsidised private services. By 2004, when subsidies had been extended to the whole adult population, this increased to almost every second adult. The PDS reported having seen 118 076 more adult patients in 2004 than in 2000. The private sector had the same number of patients but 542 656 of them had not previously been entitled to partial reimbursement of fees. The use of both public and subsidised private services increased most in big cities and urban municipalities where access to the PDS had been poor and the number of private practitioners was high. The PDS employed more dentists (6.5% and the number of private practitioners fell by 6.9%. The total dental care expenditure (PDS plus private

  3. [Postoperative pain management. Aims and organization of a strategy for postoperative acute pain therapy].

    Science.gov (United States)

    Nolli, M; Nicosia, F

    2000-09-01

    The Health Services, not only the Italian one, is under pressure because of request for improving treatment quality and the financial need for reorganization and cost-saving. It's required a rationalization of intervention, together with a careful choice of the best and cheapest techniques and the demonstration of their efficacy. The anaesthesia service activity, in a period of cost rationalization and funds restriction should be aimed to appropriate outcome measures corrected by both patient's risk factors and surgical-anaesthesiological case-mix. The development of a complete strategy for surgical pain management might run into two phases. The first phase, internal and mono-specialistic, should develop like the creation of an Acute Pain Team. The main processes are: focusing the problem (charge of the care), training, information, teaching methodology (timing, methods, drugs, techniques, etc.) and the audit (before and after changes). The main aims are the evaluation of the level of analgesia and pain relief or patient's satisfaction which are partial endpoints useful to demonstrate the improvement and the efficacy of the new pain management strategies. The second phase, multidisciplinary, is directed toward the creation of a Postoperative Evaluation Team. The main objective is to set up a collaborative clinical group able to identify the criteria for quality, efficacy and safety. The major purpose is the evaluation of major outcome measures: surgical outcome, morbidity, mortality and length of hospitalization. The improvement in the quality of postoperative pain treatment goes through a better organization and a progressive increase of the already available therapy. The achievement of the result and the quality projects depend on the interaction among staff members with different behaviours and settings. Internal teaching and training, continuous education for doctors and nurses, and external information, marketing and improvement of attractive capability of

  4. The Drosophila melanogaster homolog of UBE3A is not imprinted in neurons.

    Science.gov (United States)

    Hope, Kevin A; LeDoux, Mark S; Reiter, Lawrence T

    2016-09-01

    In mammals, expression of UBE3A is epigenetically regulated in neurons and expression is restricted to the maternal copy of UBE3A. A recent report claimed that Drosophila melanogaster UBE3A homolog (Dube3a) is preferentially expressed from the maternal allele in fly brain, inferring an imprinting mechanism. However, complex epigenetic regulatory features of the mammalian imprinting center are not present in Drosophila, and allele specific expression of Dube3a has not been documented. We used behavioral and electrophysiological analysis of the Dube3a loss-of-function allele (Dube3a 15b ) to investigate Dube3a imprinting in fly neurons. We found that motor impairment (climbing ability) and a newly-characterized defect in synaptic transmission are independent of parental inheritance of the Dube3a 15b allele. Furthermore, expression analysis of coding single nucleotide polymorphisms (SNPs) in Dube3a did not reveal allele specific expression differences among reciprocal crosses. These data indicate that Dube3a is neither imprinted nor preferentially expressed from the maternal allele in fly neurons.

  5. Development of gas analyzer to aim for speed and high sensitivity and shaping of mass spectrum

    International Nuclear Information System (INIS)

    Hatano, Toshihisa; Hiratsuka, Hajime; Abe, Tetsuya

    2011-01-01

    The gas analysis system with EI-QMS (Electron Ionization-Quadrupole Mass Spectrometer) developed by Japan Atomic Energy Agency (JAEA) is commercially available from a private company through a technology transfer. The system has already been used to a medical field such as breath analysis, a quality control of automobile casting parts made of recycled aluminum, and a measurement of food aromatic elements emitting from vegetable and sake. A pulse gas sampling and a continuous evacuation were integrated to the system that aimed at obtaining high sensitive and stable mass spectrum and accomplishing fast measurement prepared for 100% inspection of industrial parts and various foods. As a result, the system achieved a background pressure of 10 -7 Pa and a background ion current of 10 -13 A in the normal condition. An intensity of the mass spectrum decreased linearly with decreasing the pressure by the continuous evacuation, therefore, the intensity of the mass spectrum was corrected by the pump down curve, which is a new mathematical approach equivalent to a constant pressure curve. It was confirmed that the system had the sensing performance of 100 ppb. (author)

  6. Utility of extra-oral aiming device in imaging periapical regions of posterior teeth.

    Science.gov (United States)

    S, Sudhakar; P, Ramaswamy; B, Smitha; G, Uday

    2014-10-01

    Intraoral film placement and the film holding equipments are not acceptable by many due to varied reasons. To evaluate the utility of extra-oral aiming device developed by Chia-hui chen for imaging the periapical regions of posterior teeth employing the technique suggested by saberi et al. The study subjects included 20 patients in the age group of 10-35 y. The subjects were further subdivided according to the area to be imaged into four groups, with 5 in each. Imaging was done using the device developed by chia-hui chen, with the method employed by newmann and saberi et al., The radiographs were then interpreted for complete coverage of the anatomical structure. The findings were recorded and subjected to Analysis of variance (ANOVA) statistical analysis. The visibility of imaging area was more in mandible (95%) than maxilla (86.5%). The overall accuracy was 90.75%. These findings were statistically non-significant (F- 2.152 & P-0.134). Among the reason for reduced accuracy, overlapping of the opposite arch (4%) was more common and the horizontal overlapping (0.5%) was least common. This technique is not meant to replace conventional intraoral radiography. It is a useful supplementary aid to our clinical practice.

  7. Assessing biofuels: Aiming for sustainable development or complying with the market?

    International Nuclear Information System (INIS)

    Diaz-Chavez, Rocio A.

    2011-01-01

    The growing interest in biofuels has led to increasing concern about their wider implications, particularly if grown for transport use in large scale. Such concerns include environmental, social and economic issues. To counterbalance the possible negative effects, a series of measures are being put in place to help their sustainability. Nevertheless, considering the different meanings of sustainability in different parts of the world and the need to expand productive rural activities, the differences between trying to assure a commodity and the benefits or impacts at local level raise the questions between the aims of sustainability and the need to comply with a market. The ideal situation would be to reconcile both aspects, which in practise represent a major challenge for governments and industry. This paper provides an overview on the sustainability assessment of biofuels to consider a possible way forward. - Highlights: → Multi-interactions in biomass production for bioenergy are a new paradigm to develop policies. → Certification and verification schemes are limited to assess broader sustainability issues. → Improved agricultural and forestry systems for biomass use will boost policies and investment.

  8. Establishing an Anaesthesia and Intensive Care partnership and aiming for national impact in Tanzania.

    Science.gov (United States)

    Ulisubisya, Mpoki; Jörnvall, Henrik; Irestedt, Lars; Baker, Tim

    2016-03-18

    Anaesthesia and Intensive Care is a neglected specialty in low-income countries. There is an acute shortage of health workers - several low-income countries have less than 1 anaesthesia provider per 100,000 population. Only 1.5% of hospitals in Africa have the intensive care resources needed for managing patients with sepsis. Health partnerships between institutions in high and low-income countries have been proposed as an effective way to strengthen health systems. The aim of this article is to describe the origin and conduct of a health partnership in Anaesthesia and Intensive Care between institutions in Tanzania and Sweden and how the partnership has expanded to have an impact at regional and national levels.The Muhimbili-Karolinska Anaesthesia and Intensive Care Collaboration was initiated in 2008 on the request of the Executive Director of Muhimbili National Hospital in Dar es Salaam. The partnership has conducted training courses, exchanges, research projects and introduced new equipment, routines and guidelines. The partnership has expanded to include all hospitals in Dar es Salaam. Through the newly formed Life Support Foundation, the partnership has had a national impact assisting the reanimation of the Society of Anaesthesiologists of Tanzania and has seen a marked increase of the number of young doctors choosing a residency in Anaesthesia and Intensive Care.

  9. Mathematical literacy in Plant Physiology undergraduates: results of interventions aimed at improving students' performance

    Science.gov (United States)

    Vila, Francisca; Sanz, Amparo

    2013-09-01

    The importance of mathematical literacy in any scientific career is widely recognized. However, various studies report lack of numeracy and mathematical literacy in students from various countries. In the present work, we present a detailed study of the mathematical literacy of Spanish undergraduate students of Biology enrolled in a Plant Physiology course. We have performed individual analyses of results obtained during the period 2000-2011, for questions in the examinations requiring and not requiring mathematical skills. Additionally, we present the outcome of two interventions introduced with the aim of helping students improve their prospects for success in the course. Our results confirm previous research showing students' deficiencies in mathematical skills. However, the scores obtained for mathematical questions in the examinations are good predictors of the final grades attained in Plant Physiology, as there are strong correlations at the individual level between results for questions requiring and not requiring mathematical skills. The introduction of a laboratory session devoted to strengthening the application of students' previously acquired mathematical knowledge did not change significantly the results obtained for mathematical questions. Since mathematical abilities of students entering university have declined in recent years, this intervention may have helped to maintain students' performance to a level comparable to that of previous years. The outcome of self-assessment online tests indicates that although Mathematics anxiety is lower than during examinations, the poor results obtained for questions requiring mathematical skills are, at least in part, due to a lack of self-efficacy.

  10. Evaluation of activities aimed at preventing microbiological risks in dental practice

    Directory of Open Access Journals (Sweden)

    Jolanta Szymańska

    2013-02-01

    Full Text Available Background: Microbiological contamination of water in dental unit waterlines (DUWL creates a risk of cross-infections, and is a source of biological risk factors in the work environment of a dentist. The aim of the study was to evaluate dentists' knowledge on DUWL microbiological contamination and the scope of activities/procedures they undertake to monitor it. Material and Methods: The questionnaire survey was conducted in 2010 among 107 Polish dentists using dental units in everyday clinical practice. Results: It has been found that in their daily practice, dentists do not follow procedures leading to reduction or elimination of microbiological contamination of dental unit reservoir water. They are not aware of microbiological contamination of DUWL that supply working handpieces with water. They are unaware of the principles of dealing with dental water and water supply systems or the health risk posed by microbiological contamination of unit water for a dental team and patients. Conclusions: It is necessary to provide dentists with information on microbiological contamination of water in dental units, on the correct procedures of handling water and waterlines that supply working handpieces with water. Med Pr 2013;64(1:11–17

  11. Pioneering and Interprofessional Pediatric Dentistry Programs Aimed at Reducing Oral Health Disparities

    Science.gov (United States)

    Ramos-Gomez, Francisco; Askaryar, Hamida; Garell, Cambria; Ogren, Jennifer

    2017-01-01

    Early Childhood Caries (ECC) is the most chronic childhood disease and more predominant in low-income and underserved children. Although easily transmitted, ECC is entirely preventable. Dr. Ramos-Gomez and his team at the University of California, Los Angeles put together an interprofessional curriculum where both medical and dental knowledge and practice is integrated to prepare dentists and primary care providers to more cost effectively address ECC and thereby reduce disparities in oral health. The curriculum, known as the Strategic Partnership for Interprofessional Collaborative Education in Pediatric Dentistry (SPICE-PD), consists of nine evidence-based training modules: applied statistics and research, community partners, interprofessional education/training, quality improvement, policy and advocacy, disease management/risk assessment, ethics/professionalism, cultural competency and children with special heath-care needs. SPICE aims to prepare pediatric dental residents and primary care providers to provide preventive, culturally competent, and minimally invasive oral care for underserved, low income, and special needs children. Additionally, the Infant Oral Care Program (IOCP), located at a local community health clinic, provides culturally sensitive preventive oral health care for children aged 0–5 years. The medical–dental integration model utilized at IOCP helps reduce oral health disparities by providing a systems-based and cost-effective approach to combat the burden of ECC. To track the progress of SPICE, a comprehensive evaluation framework has been designed, which aligns goals and objectives with program activities, desired outcomes, and measured indicators. PMID:28856133

  12. Research Networking Systems: The State of Adoption at Institutions Aiming to Augment Translational Research Infrastructure

    Science.gov (United States)

    Obeid, Jihad S; Johnson, Layne M; Stallings, Sarah; Eichmann, David

    2015-01-01

    Fostering collaborations across multiple disciplines within and across institutional boundaries is becoming increasingly important with the growing emphasis on translational research. As a result, Research Networking Systems that facilitate discovery of potential collaborators have received significant attention by institutions aiming to augment their research infrastructure. We have conducted a survey to assess the state of adoption of these new tools at the Clinical and Translational Science Award (CTSA) funded institutions. Survey results demonstrate that most CTSA funded institutions have either already adopted or were planning to adopt one of several available research networking systems. Moreover a good number of these institutions have exposed or plan to expose the data on research expertise using linked open data, an established approach to semantic web services. Preliminary exploration of these publically-available data shows promising utility in assessing cross-institutional collaborations. Further adoption of these technologies and analysis of the data are needed, however, before their impact on cross-institutional collaboration in research can be appreciated and measured. PMID:26491707

  13. Cultural influence on aims of inclusion of mothers in pre-school children's play

    Directory of Open Access Journals (Sweden)

    Mihić-Lisul Ivana

    2002-01-01

    Full Text Available Child is introduced with the contents of culture at first through numerous influences culture has on family life, especially on defining parenting roles. Patriarchal culture, still strong in Yugoslavia, is full of norms that clearly define roles of elders and men, and excellently demarcates differences between father's and mother's role in bringing up their children, defined by the level of responsibility attached to parents in upbringing and educating a child. Research conducted in Novi Sad, Yugoslavia in January 2002, with the primary aim of diagnosing differences in frequency and quality of parent-pre-school children play concerning many relevant correlates, most important of which is the sex of the parent. Data show high distinctive quality difference in types and approaches to play in regard of the parent in question. Differences show that patriarchal culture's influence is still very strong. The results show that mothers are burdened with the higher level of responsibility, inevitably leading to higher parenting stress. The level of parenting stress can then influence the quality of meeting the requests put to parents, as well as raising level of general anxiety in all the activities concerning the child, therefore the play itself as well.

  14. PLA and two components silicon rubber blends aiming for frozen foods packaging applications

    Directory of Open Access Journals (Sweden)

    Utai Meekum

    2018-03-01

    Full Text Available Designing of PLA and two components silicone rubber blends was studies. Frozen food packaging application is the main ultimate aim. The statistical method using 23 DOE was conducted. The standard testing methods, in particular impact testing at sub-zero temperature, were performed. The preliminary blend formula comprised 1.0 phr of silane and polyester polyols, respectively, was initially resolved. Then, the optimize the silicone portion in the blends was determined. Blending formula using 8.0 phr of silicone with respect to PLA matrix gave rise to the overall satisfactory properties. 3. TETA was used as the silicone curing agent and reactively blended onto the ingredients. TETA at 0.4 phr, with respect to the silicone, enhanced the mechanical properties, especially flexibility and toughness, of the PLA/silicone blend. Exceeding the optimal TETA loading would cause the chain scission and also the dilution effects. Hence, marginal inferior properties of the blends were be experienced. The preliminary biodegradability investigation found that the PLA/silicone blend initially triggered at the second week. Its degradation rate was likely to be faster than neat PLA. Keywords: PLA/silicone blends, Mechanical properties, Sub-zero impact strength

  15. Surface modification of an experimental silicone rubber aimed at reducing initial candidal adhesion.

    Science.gov (United States)

    Price, C; Waters, M G J; Williams, D W; Lewis, M A O; Stickler, D

    2002-01-01

    Silicone rubber, which is a widely used biomaterial, is often used to make soft liners for permanent denture. Colonization of denture soft lining materials by Candida albicans can result in clinical problems. The aim of this study was to chemically modify the surface of an experimental silicone rubber in order to produce a silicone that was less susceptible to candidal colonization. Surface modification was carried out with the use of argon-plasma bombardment followed by silane treatment, which caused the incorporation of either hydrophilic or hydrophobic functional groups onto the surface. Changes in water contact angles and chemical analysis of the materials with scanning ion mass spectroscopy confirmed surface changes. In vitro assays were carried out using C. albicans to measure levels of adherence to the surface-modified silicone after 1 h. C. albicans exhibited very low adherence to all silane-treated surfaces, whether hydrophobic or hydrophilic. This led to the conclusion that incorporated long-chain functional groups were inhibiting the adherence of the yeast, possibly by the formation of a barrier between the surface of the material and the yeast. In conclusion, silane surface treatment of an experimental silicone rubber has been successful in reducing candidal adherence. Copyright 2002 Wiley Periodicals, Inc. J Biomed Mater Res (Appl Biomater) 63: 122--128, 2002; DOI 10.1002/jbm.10094

  16. Irregular Winding of Pre-preg Fibres Aimed at the Local Improvement of Flexural Properties

    Directory of Open Access Journals (Sweden)

    Petr Kulhavy

    2017-12-01

    Full Text Available The main undisputed benefit of using long fibre composite materials, whose properties could be targeted for a particular application, lies in the efficient utilisation of material. Using a method of pre-impregnated fibre winding, a rod with a reinforced middle part was created through the local adjustment of the winding angle in order to increase the local bending stiffness. The aim of our work was to describe, experimentally and subsequently using appropriate numerical models, the behaviour of two composite rods, one with a locally variable winding angle and the other with a constant winding angle. The difference in the mechanical behaviour of both structures was clearly evident during the experiment. By using a suitable composite pre-processor and by choosing some multiple element sets, it was also possible to accurately simulate the real behaviour of such components, which actually have several regions, each with different mechanical parameters. Together with the expected different flexural strength, a traditional three-point bending test also explored the different shape of the resulting deformation in the two compared parts. Differences in the maximum strength and the mode of fi nal deformations were also identified.

  17. Performance of clonal olive tree gardens in successive cuts aiming cutting propagation

    Directory of Open Access Journals (Sweden)

    João Vieira Neto

    2011-03-01

    Full Text Available This work evaluated the performance of clonal olive tree gardens in successive cuts aiming cutting propagation. The clonal garden was installed in March 2006, in grooves 40 cm deep. Two cultivars (Ascolano 315 and Arbequina were evaluated and cut in 2007, 2008 and 2009. The test was carried out in split plot in time in a randomized block design with five replications. The plots were composed of three lines, one meter spaced between them, three plants in each line, spaced 0,5 m from each other, totaling nine plants per plot, being evaluated only the three most vigorous plants. For evaluation, three plants were pruned 20 cm height above soil, after 12 months of cultivation, it was evaluated the yield of cuttings with four knots and two pairs of leaves; plants height (m, torso diameter the 20 cm height of the soil (cm; branches length (m; and total green mass accumulated (kg. In most features evaluated, the best results were observed in the ‘Ascolano 315’. The successive cuts may be extended over a three year period. The parameter estimates indicate that plants of both cultivars y responded satisfactorily to regrowth.

  18. Geriatrics and the triple aim: defining preventable hospitalizations in the long-term care population.

    Science.gov (United States)

    Ouslander, Joseph G; Maslow, Katie

    2012-12-01

    Reducing preventable hospitalizations is fundamental to the "triple aim" of improving care, improving health, and reducing costs. New federal government initiatives that create strong pressure to reduce such hospitalizations are being or will soon be implemented. These initiatives use quality measures to define which hospitalizations are preventable. Reducing hospitalizations could greatly benefit frail and chronically ill adults and older people who receive long-term care (LTC) because they often experience negative effects of hospitalization, including hospital-acquired conditions, morbidity, and loss of functional abilities. Conversely, reducing hospitalizations could mean that some people will not receive hospital care they need, especially if the selected measures do not adequately define hospitalizations that can be prevented without jeopardizing the person's health and safety. An extensive literature search identified 250 measures of preventable hospitalizations, but the measures have not been validated in the LTC population and generally do not account for comorbidity or the capacity of various LTC settings to provide the required care without hospitalization. Additional efforts are needed to develop measures that accurately differentiate preventable from necessary hospitalizations for the LTC population, are transparent and fair to providers, and minimize the potential for gaming and unintended consequences. As the new initiatives take effect, it is critical to monitor their effect and to develop and disseminate training and resources to support the many community- and institution-based healthcare professionals and emergency department staff involved in decisions about hospitalization for this population. © 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society.

  19. Disseminating hypnosis to health care settings: Applying the RE-AIM framework

    Science.gov (United States)

    Yeh, Vivian M.; Schnur, Julie B.; Montgomery, Guy H.

    2014-01-01

    Hypnosis is a brief intervention ready for wider dissemination in medical contexts. Overall, hypnosis remains underused despite evidence supporting its beneficial clinical impact. This review will evaluate the evidence supporting hypnosis for dissemination using guidelines formulated by Glasgow and colleagues (1999). Five dissemination dimensions will be considered: Reach, Efficacy, Adoption, Implementation, and Maintenance (RE-AIM). Reach In medical settings, hypnosis is capable of helping a diverse range of individuals with a wide variety of problems. Efficacy There is evidence supporting the use of hypnosis for chronic pain, acute pain and emotional distress arising from medical procedures and conditions, cancer treatment-related side-effects and irritable bowel syndrome. Adoption Although hypnosis is currently not a part of mainstream clinical practices, evidence suggests that patients and healthcare providers are open to trying hypnosis, and may become more so when educated about what hypnosis can do. Implementation Hypnosis is a brief intervention capable of being administered effectively by healthcare providers. Maintenance Given the low resource needs of hypnosis, opportunities for reimbursement, and the ability of the intervention to potentially help medical settings reduce costs, the intervention has the qualities necessary to be integrated into routine care in a self-sustaining way in medical settings. In sum, hypnosis is a promising candidate for further dissemination. PMID:25267941

  20. Institutional policy changes aimed at addressing obesity among mental health clients.

    Science.gov (United States)

    Knol, Linda L; Pritchett, Kelly; Dunkin, Jeri

    2010-05-01

    People with mental illness often experience unique barriers to healthy eating and physical activity. For these clients, interventions should focus on changes in the immediate environment to change behaviors. The purpose of this project was to implement and evaluate policy changes that would limit calorie intake and increase calorie expenditure of clients receiving mental health services. This intervention was implemented in a rural mental health system in the southeastern United States. Clients live in small group homes, where they are served breakfast, dinner, and a snack, and attend outpatient day treatment programs, where they are served lunch and can purchase snacks from vending machines. This intervention included institutional policy changes that altered menus and vending machine options and implemented group walking programs. Primary outcome measures were changes in clients' weight at 3 and 6 months after policy implementation. At the 3-month follow-up, the median weight loss for overweight/obese clients (n = 45) was 1.4 kg. The 33 overweight/obese clients who were still in the group homes at the 6-month follow-up either maintained or continued to lose weight. Institutional policy changes aimed at improving dietary intake and physical activity levels among clients receiving mental health services can promote weight loss in overweight clients.

  1. Proposal of a weight factor for alpha radiation aiming biota radioprotection

    International Nuclear Information System (INIS)

    Pereira, Wagner de S.; Py Junior, Delcy de A.; Kelecom, Alphonse; Goncalves, Simone

    2009-01-01

    Several proposals based on the environmental radioprotection of calculating the absorbed dose in biota have been suggested. The absorbed dose expresses the deposition of energy per mass unit. The differences in biological effects of the absorbed dose can be quantified by applying a correction factor to the absorbed dose. The correction factor for radiation is easier to establish, because radiations exist in smaller number (alpha, beta, neutrons and photons) and can be set for groups of organisms. This work aims to propose a correction factor for radiation, in order to adequate the concept of absorbed dose currently used to the concept of equivalent dose. A survey of the literature on correction factors proposed for alpha radiation was carried out and, when possible, the biological endpoint was identified, as well as the radionuclide and the biological target. A variation of the weight factor for alpha radiation from 1 to 377 was observed and a number of biological endpoints, biological target and alpha emitter radionuclide were identified. Finally we propose a weight value for alpha radiation of 40, and we propose also the name of correction factor for radiation alpha as being ecological radiation weighting factor (WRE) the name 'equivalent dose for flora and fauna' (HTFF) to name of the new dose. (author)

  2. Pioneering and Interprofessional Pediatric Dentistry Programs Aimed at Reducing Oral Health Disparities.

    Science.gov (United States)

    Ramos-Gomez, Francisco; Askaryar, Hamida; Garell, Cambria; Ogren, Jennifer

    2017-01-01

    Early Childhood Caries (ECC) is the most chronic childhood disease and more predominant in low-income and underserved children. Although easily transmitted, ECC is entirely preventable. Dr. Ramos-Gomez and his team at the University of California, Los Angeles put together an interprofessional curriculum where both medical and dental knowledge and practice is integrated to prepare dentists and primary care providers to more cost effectively address ECC and thereby reduce disparities in oral health. The curriculum, known as the Strategic Partnership for Interprofessional Collaborative Education in Pediatric Dentistry (SPICE-PD), consists of nine evidence-based training modules: applied statistics and research, community partners, interprofessional education/training, quality improvement, policy and advocacy, disease management/risk assessment, ethics/professionalism, cultural competency and children with special heath-care needs. SPICE aims to prepare pediatric dental residents and primary care providers to provide preventive, culturally competent, and minimally invasive oral care for underserved, low income, and special needs children. Additionally, the Infant Oral Care Program (IOCP), located at a local community health clinic, provides culturally sensitive preventive oral health care for children aged 0-5 years. The medical-dental integration model utilized at IOCP helps reduce oral health disparities by providing a systems-based and cost-effective approach to combat the burden of ECC. To track the progress of SPICE, a comprehensive evaluation framework has been designed, which aligns goals and objectives with program activities, desired outcomes, and measured indicators.

  3. PLA and two components silicon rubber blends aiming for frozen foods packaging applications

    Science.gov (United States)

    Meekum, Utai; Khiansanoi, Apichart

    2018-03-01

    Designing of PLA and two components silicone rubber blends was studies. Frozen food packaging application is the main ultimate aim. The statistical method using 23 DOE was conducted. The standard testing methods, in particular impact testing at sub-zero temperature, were performed. The preliminary blend formula comprised 1.0 phr of silane and polyester polyols, respectively, was initially resolved. Then, the optimize the silicone portion in the blends was determined. Blending formula using 8.0 phr of silicone with respect to PLA matrix gave rise to the overall satisfactory properties. 3. TETA was used as the silicone curing agent and reactively blended onto the ingredients. TETA at 0.4 phr, with respect to the silicone, enhanced the mechanical properties, especially flexibility and toughness, of the PLA/silicone blend. Exceeding the optimal TETA loading would cause the chain scission and also the dilution effects. Hence, marginal inferior properties of the blends were be experienced. The preliminary biodegradability investigation found that the PLA/silicone blend initially triggered at the second week. Its degradation rate was likely to be faster than neat PLA.

  4. What Aims, what Motives? Determining Research Priorities in the International Indian Ocean Expedition, 1960-1965

    Science.gov (United States)

    Doel, R.

    2016-12-01

    Fundamental tensions affected planning for United States involvement in the International Indian Ocean Expedition (IIOE). At the highest levels of the US state, science advisors and State Department officials praised the proposed Indian Ocean research plan—loosely modeled on the recently completed International Geophysical Year of 1957-58—as a way of promoting scientific internationalism, seeing this undertaking as a way to help bring India more firmly within the Western sphere amid Cold War East-West conflicts. Dwight D. Eisenhower's presidential science advisor, George Kistiakowsky, had the IIOE in mind when he advised the National Security Council that a key role science could play in American foreign relations lay "in relation with the neutral and less-developed countries." At the same time, American scientists invited to take part in the Indian Ocean Expedition—while generally sympathetic with U.S. foreign policy aims—prioritized research programs in the physical branches of the environmental sciences. While policy-makers hoped to encourage biological research, with the aim of encouraging fisheries and protein production to aid Indian citizens, earth scientists—better-funded, better-organized, supported by military agencies because their studies were crucial to national security—came to dominate the IIOE. While the IIOE was later judged a success, for it extended long-running research programs in physical and chemical oceanography into a less-explored ocean, hopes to advance biological programs on an equal footing proved premature.

  5. Shared decision-making as an existential journey: Aiming for restored autonomous capacity.

    Science.gov (United States)

    Gulbrandsen, Pål; Clayman, Marla L; Beach, Mary Catherine; Han, Paul K; Boss, Emily F; Ofstad, Eirik H; Elwyn, Glyn

    2016-09-01

    We describe the different ways in which illness represents an existential problem, and its implications for shared decision-making. We explore core concepts of shared decision-making in medical encounters (uncertainty, vulnerability, dependency, autonomy, power, trust, responsibility) to interpret and explain existing results and propose a broader understanding of shared-decision making for future studies. Existential aspects of being are physical, social, psychological, and spiritual. Uncertainty and vulnerability caused by illness expose these aspects and may lead to dependency on the provider, which underscores that autonomy is not just an individual status, but also a varying capacity, relational of nature. In shared decision-making, power and trust are important factors that may increase as well as decrease the patient's dependency, particularly as information overload may increase uncertainty. The fundamental uncertainty, state of vulnerability, and lack of power of the ill patient, imbue shared decision-making with a deeper existential significance and call for greater attention to the emotional and relational dimensions of care. Hence, we propose that the aim of shared decision-making should be restoration of the patient's autonomous capacity. In doing shared decision-making, care is needed to encompass existential aspects; informing and exploring preferences is not enough. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. Impact of school-based health promotion interventions aimed at different behavioral domains: a systematic review.

    Science.gov (United States)

    Lima-Serrano, Marta; Lima-Rodríguez, Joaquín S

    2014-01-01

    Given that lifestyleshave similar determinants and that school-based interventions are usually targeted at all the risks that affect adolescents, the objective of this systematic review was to summarize the characteristics and effects of school-based interventions acting on different behavioral domains of adolescent health promotion. The review process was conducted by two independent reviewers who searched PubMed, Scopus, PsycINFO, and ERIC databases for experimental or observational studies with at least two measures of results published from 2007 to 2011, given that the research information available doubles every 5 years. Methodological quality was assessed with a standardized tool. Information was extracted from 35 studies aiming to prevent risk behaviors and promote healthy nutrition, physical activity, and mental and holistic health. Activities were based on theoretical models and were classified into interactive lessons, peer mediation, environmental changes, parents' and community activities, and tailored messages by computer-assisted training or other resources, usually including multiple components. In some cases, we identified some moderate to large, short- and long-term effects on behavioral and intermediate variable. This exhaustive review found that well-implemented interventions can promote adolescent health. These findings are consistent with recent reviews. Implications for practice, public health, and research are discussed. Copyright © 2014 SESPAS. Published by Elsevier Espana. All rights reserved.

  7. Investigating Gravity Waves in Polar Mesospheric Clouds Using Tomographic Reconstructions of AIM Satellite Imagery

    Science.gov (United States)

    Hart, V. P.; Taylor, M. J.; Doyle, T. E.; Zhao, Y.; Pautet, P.-D.; Carruth, B. L.; Rusch, D. W.; Russell, J. M.

    2018-01-01

    This research presents the first application of tomographic techniques for investigating gravity wave structures in polar mesospheric clouds (PMCs) imaged by the Cloud Imaging and Particle Size instrument on the NASA AIM satellite. Albedo data comprising consecutive PMC scenes were used to tomographically reconstruct a 3-D layer using the Partially Constrained Algebraic Reconstruction Technique algorithm and a previously developed "fanning" technique. For this pilot study, a large region (760 × 148 km) of the PMC layer (altitude 83 km) was sampled with a 2 km horizontal resolution, and an intensity weighted centroid technique was developed to create novel 2-D surface maps, characterizing the individual gravity waves as well as their altitude variability. Spectral analysis of seven selected wave events observed during the Northern Hemisphere 2007 PMC season exhibited dominant horizontal wavelengths of 60-90 km, consistent with previous studies. These tomographic analyses have enabled a broad range of new investigations. For example, a clear spatial anticorrelation was observed between the PMC albedo and wave-induced altitude changes, with higher-albedo structures aligning well with wave troughs, while low-intensity regions aligned with wave crests. This result appears to be consistent with current theories of PMC development in the mesopause region. This new tomographic imaging technique also provides valuable wave amplitude information enabling further mesospheric gravity wave investigations, including quantitative analysis of their hemispheric and interannual characteristics and variations.

  8. AIM - Agile Instrumented Monitoring for Improving User Experience of Participation in HealthIT Development.

    Science.gov (United States)

    Pitkänen, Janne; Nieminen, Marko

    2017-01-01

    Participation of healthcare professionals in information technology development has emerged as an important challenge. As end-users, the professionals are willing to participate in the development activities, but their experiences on the current methods of participation remain mostly negative. There is lack of applicable methods for meeting the needs of agile development approach and scaling up to the largest implementation projects, while maintaining the interest of the professional users to participate in development activities and keeping up their ability to continue working in a productive manner. In this paper, we describe the Agile Instrumented Monitoring as a methodology, based on the methods of instrumented usability evaluation, for improving user experience in HealthIT development. The contribution of the proposed methodology is analyzed in relation to activities of whole iteration cycle and chosen usability evaluation methods, while the user experience of participation is addressed regarding healthcare professionals. Prospective weak and strong market tests for AIM are discussed in the conclusions for future work.

  9. Pioneering and Interprofessional Pediatric Dentistry Programs Aimed at Reducing Oral Health Disparities

    Directory of Open Access Journals (Sweden)

    Francisco Ramos-Gomez

    2017-08-01

    Full Text Available Early Childhood Caries (ECC is the most chronic childhood disease and more predominant in low-income and underserved children. Although easily transmitted, ECC is entirely preventable. Dr. Ramos-Gomez and his team at the University of California, Los Angeles put together an interprofessional curriculum where both medical and dental knowledge and practice is integrated to prepare dentists and primary care providers to more cost effectively address ECC and thereby reduce disparities in oral health. The curriculum, known as the Strategic Partnership for Interprofessional Collaborative Education in Pediatric Dentistry (SPICE-PD, consists of nine evidence-based training modules: applied statistics and research, community partners, interprofessional education/training, quality improvement, policy and advocacy, disease management/risk assessment, ethics/professionalism, cultural competency and children with special heath-care needs. SPICE aims to prepare pediatric dental residents and primary care providers to provide preventive, culturally competent, and minimally invasive oral care for underserved, low income, and special needs children. Additionally, the Infant Oral Care Program (IOCP, located at a local community health clinic, provides culturally sensitive preventive oral health care for children aged 0–5 years. The medical–dental integration model utilized at IOCP helps reduce oral health disparities by providing a systems-based and cost-effective approach to combat the burden of ECC. To track the progress of SPICE, a comprehensive evaluation framework has been designed, which aligns goals and objectives with program activities, desired outcomes, and measured indicators.

  10. Preparation and characterization of two organoclays aiming its use in adsorption processes

    International Nuclear Information System (INIS)

    Vazzoler, H.; Valenzuela-Diaz, F.R.; Vazzoler, F.D.

    2014-01-01

    Were prepared two organoclays aiming at studying their adsorption properties. The clayssed were the Brazilian Bentongel and Argentina Green Lake. The clays were characterized and organoclays. Performed analyzes of X-Ray diffraction, infrared, SEM, thermogravimetry and swelling experiments Foster and adsorption ASTM. The X-ray diffraction indicated collation of lamellar organic cation used. The variations thermogravimetrics were negative and ranged from around 24% in organophilic clays. The results of infrared spectroscopy indicated the presence of bands that show this barge. The form of the particles/agglomerates of clay minerals was verified by SEM before and after organofilization. The values of the measures of swelling were up to 30 mL/g for some solvents. The adsorption test showed good ability of sorption per gram of clay, reaching respectively 10.2g/g and 9.9 g/g for gasoline and ethylbenzene. These high values indicate that the modified clay may have potential use in sectors of environmental toxicity control industrial and separation. (author)

  11. 20 years TraumaRegister DGU(®): development, aims and structure.

    Science.gov (United States)

    2014-10-01

    The TraumaRegister DGU(®) organisational and technical development has undergone an evolution process, which started 20 years ago. Currently, the management of the registry is under the management of the "AUC - Academy for Trauma Surgery" (infrastructure) and the "Sektion NIS" (scientific responsibility). The aim of the registry was to establish an inter-hospital quality assessment tool with the option to use the increasing database for scientific evaluations of acute care. Year after year and most recently with the obligatory participation of certified hospitals the number of participating hospitals has grown as well as the registered cases per annum. Recently, even hospitals from other countries joined the registry too. Starting with six German hospitals and 260 cases in 1993, 20 years later more than 600 hospitals from eleven countries deliver over 30,000 trauma cases per year resulting in over 150,000 reported cases until 2013. In this article a historical perspective is presented of the evolution and current status of the TraumaRegister DGU(®). Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Interventions aimed at improving the ability to use everyday technology in work after brain injury.

    Science.gov (United States)

    Kassberg, Ann-Charlotte; Prellwitz, Maria; Malinowsky, Camilla; Larsson-Lund, Maria

    2016-01-01

    The aim of this study was to explore and describe how client-centred occupational therapy interventions may support and improve the ability to use everyday technology (ET) in work tasks in people with acquired brain injury (ABI). A qualitative, descriptive multiple-case study was designed, and occupation-based interventions were provided to three working-age participants with ABI. Multiple sources were used to collect data throughout the three intervention processes, including assessments, field notes, and interviews. The Canadian Occupational Performance Measure and the Management of Everyday Technology Assessment were administered before the interventions, after the interventions and at a follow-up session 2-3 months subsequent to the interventions. The three intervention processes initially consisted of similar actions, but subsequently the actions took on a different focus and intensity for each case. All of the goals in each of the three case processes were achieved, and both perceived and observed abilities to use ET in work tasks improved. Client-centred occupational therapy interventions might have the potential to improve the ability to use ET in work tasks in people with ABI.

  13. Making didactics proposals aimed at improving socioeducational programs for youngters at risk of social exclusion

    Directory of Open Access Journals (Sweden)

    María Violeta Álvarez Fernández

    2013-12-01

    Full Text Available Educators at Sograndio Juvenile Detention Center in Asturias were sure that they were able to offer new alternatives to improve their socio-educational intervention. That is the reason why they got involved in an action research training process aimed at making didactic proposals which tried to optimize the development of social competence programs for youngsters with criminal behavior. In order to do this, the Short Version of the Prosocial Thinking Program for Young People (Alba et al., 2005 was applied to nine inmates, eight males between 14 and 20 years old and a female of 16 years old. Theywere the basis and reflection of ourmethodological intervention. The teamtaking part in this intervention is formed by nine inmates and three external members (two coordinators and a woman psychologist. The investigation, mainly qualitative, includes different instruments (both qualitative and quantitative, such as: observation registries, discussion groups, questionnaires and notebooks. After the implementation of the program, positive changes must be highlighted in the emotional dimension, the resolution of problems, self-control and frustration tolerance. Besides, very high levels of satisfaction have been observed among youngsters, educators and external informants. It is important to have created a climate of professional compromise towards change and this way to have abandoned a passive attitude towards training, so that we were able to start an active search for practical answers, adjusted to our necessities and professional interests. Finally, we make several observations and intervention proposals that contribute to generate didactic knowledge thought and adapted for social education.

  14. Screening of thermotolerant and thermophilic fungi aiming β-xylosidase and arabinanase production

    Science.gov (United States)

    Benassi, Vivian Machado; de Lucas, Rosymar Coutinho; Jorge, João Atílio; Polizeli, Maria de Lourdes Teixeira de Moraes

    2014-01-01

    Plant cell wall is mainly composed by cellulose, hemicellulose and lignin. The heterogeneous structure and composition of the hemicellulose are key impediments to its depolymerization and subsequent use in fermentation processes. Thus, this study aimed to perform a screening of thermophilic and thermotolerant filamentous fungi collected from different regions of the São Paulo state, and analyze the production of β-xylosidase and arabinanase at different temperatures. These enzymes are important to cell wall degradation and synthesis of end products as xylose and arabinose, respectively, which are significant sugars to fermentation and ethanol production. A total of 12 fungal species were analyzed and 9 of them grew at 45 °C, suggesting a thermophilic or thermotolerant character. Additionally Aspergillus thermomutatus anamorph of Neosartorya and A. parasiticus grew at 50 °C. Aspergillus niger and Aspergillus thermomutatus were the filamentous fungi with the most expressive production of β-xylosidase and arabinanase, respectively. In general for most of the tested microorganisms, β-xylosidase and arabinanase activities from mycelial extract (intracellular form) were higher in cultures grown at high temperatures (35–40 °C), while the correspondent extracellular activities were favorably secreted from cultures at 30 °C. This study contributes to catalogue isolated fungi of the state of São Paulo, and these findings could be promising sources for thermophilic and thermotolerant microorganisms, which are industrially important due to their enzymes. PMID:25763055

  15. Acid hydrolysis of sisal cellulose: studies aiming at nano fibers and bio ethanol preparation

    International Nuclear Information System (INIS)

    Paula, Mauricio P. de; Lacerda, Talita M.; Zambon, Marcia D.; Frollini, Elisabete

    2009-01-01

    The hydrolysis of cellulose can result in nanofibers and also is an important stage in the bioethanol production process. In order to evaluate the influence of acid (sulfuric) concentration, temperature, and native cellulose (sisal) pretreatment on cellulose hydrolysis, the acid concentration was varied between 5% and 30% (v/v) in the temperature range from 60 to 100 deg C using native and alkali-treated (mercerized) sisal cellulose. The following techniques were used to evaluate the residual (non-hydrolysed) cellulose characteristics: viscometry, average degree of polymerization (DP), X-ray diffraction, crystallinity index, and Scanning Electron Microscopy. The sugar cane liquor was analyzed in terms of sugar composition, using High Performance Liquid Chromatography (HPLC). The results showed that increasing the concentration of sulfuric acid and temperature afforded residual cellulose with lower molecular weight and, up to specific acid concentrations, higher crystallinity indexes, when compared to the original cellulose values, and increased the glucose (the bioethanol precursor ) production of the liquor, which was favored for mercerized cellulose. (author)

  16. Impact of processes of care aimed at complication reduction on the cost of complex cancer surgery.

    Science.gov (United States)

    Short, Marah N; Ho, Vivian; Aloia, Thomas A

    2015-11-01

    Health care providers add multiple processes to the care of complex cancer patients, believing they prevent and/or ameliorate complications. However, the relationship between these processes, complication remediation, and expenditures is unknown. Data for patients with cancer diagnoses undergoing colectomy, rectal resection, pulmonary lobectomy, pneumonectomy, esophagectomy, and pancreatic resection were obtained from hospital and inpatient physician Medicare claims for the years 2005-2009. Risk-adjusted regression analyses measured the association between hospitalization costs and processes presumed to prevent and/or remedy complications common to high-risk procedures. After controlling for comorbidities, analysis identified associations between increased costs and use of multiple processes, including arterial lines (4-12% higher; P costs. Consultations were associated with 24-44% (P costs, and total parenteral nutrition was associated with 13-31% higher costs (P processes and services presumed to avoid and/or ameliorate complications are associated with increased surgical oncology costs. This suggests that the patient-centered value of each process should be measured on a procedure-specific basis. Likewise, further attention should be focused on defining the efficacy of each of these costly, but frequently unproven, additions to perioperative care. © 2015 Wiley Periodicals, Inc.

  17. Produced water reuse aiming reinjection; Reuso de agua produzida visando reinjecao

    Energy Technology Data Exchange (ETDEWEB)

    Louvisse, Ana Maria Travalloni; Hora, Jairo Maynard da Fonseca; Guilherme, Claudio [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    2004-07-01

    As an oil reservoir goes aging, the BSW (water and solid content associated to the crude oil ) from the produced oil increase acutely. As this associated water is isolated from the crude oil, it presents several contaminants with concentrations above to that specified in the environmental norms for its discharge. Attending the environmental legislation, some times, is very difficult and can even enable the entire project. As the reservoir becomes old, enhance techniques are necessary to maintain the oil producing. A common recovery mechanism, called secondary recovery, is the water injection. Commonly the water for secondary recovery is not easily available. The main objective of this work is present a treatment system for produced water used in a specific field in the Northwest region. This treatment involves reinjection of this water after filtration. We will have a high environmental benefited, avoiding the discharge of produced water, highly toxic, and at the same time enhanced the oil production. In this work, we develop a method to modify the physical chemistry characteristics of the produced water and increase the treatment process efficiency. (author)

  18. Neuroenhancement and the Developing Brain: Commentary on the AIMS Neuroscience Special Issue on “Neuroenhancers”

    Directory of Open Access Journals (Sweden)

    Sarah Ly

    2015-10-01

    Full Text Available The use of pharmaceutical neuroenhancers to improve cognitive function poses unique neurobiological concerns as stimulants are being widely prescribed to adolescents and young adults with increasing prevalence. In the following commentary on the papers by Hoffman et al [1] and Cheung and Pierre [2] in the special issue on Neuroenhancers, we discuss the need to consider the effects of stimulant use in healthy adolescents. We review some of the data that has emerged on the neurobiological and behavioral effects of adolescent neuroenhancement, and conclude that special consideration should be taken to characterize the consequences of neuroenhancement use in the developing brain. Studies focused specifically on adolescent vulnerabilities to neuroenhancement are necessary because the brain undergoes dynamics changes that are unique to this period of development, which differentiates it from the healthy adult response to neuroenhancer exposure. Moving forward, scientists and physicians should take careful consideration to examine the long-term neurological consequences of neuroenhancers so that the therapeutic benefits that might be gained from neuroenhancement are not shadowed by negative consequences to public health in the future.

  19. [Unusual behaviors in sleep as "compensatory" reactions, aimed at normalizing sleep-alertness cycles].

    Science.gov (United States)

    Gol'bin, A Ts; Guzeva, V I; Shepoval'nikov, A N

    2013-01-01

    The present article is an attempt to perform a conceptual clinical and physiological analysis of a large spec- trum of sleep-related phenomena called parasomnias in children, based on data from three independent in- stitutions. Parasonmias appear in the process of falling asleep, at the time of sleep stage changes, and upon awakening. They are common for both healthy children and those with neurological and psychiatric disorders. Brief descriptions of clinical pictures of several groups of parasomnias and their polysomnographic characteristics are presented. Instances of stereotyped rhythmic movements (e.g. head rocking), paroxysmal somatic and behavioral episodes (night terrors and nightmares), "static" phenomena (sleep with open eyes, strange body positions), as well as somnambulism are specifically described. Common features of parasomnias as a group have been identified (the "Parasomnia syndrome"). It was found that sleep architecture frequently normalizes after a parasomnia episode, whereas parasomnias are self-liquidated after sleep matures (self-cure). The significance of gender differences in parasomnias have been reviewed. Possible compensatory physiological functions of parasomnias acting as "switches" or "stabilizers" of sleep stages to "off-set" deviated or immature sleep-wake mechanisms were discussed.

  20. Aims and first assessments of the French hydrogen pathways project HyFrance3

    Energy Technology Data Exchange (ETDEWEB)

    Le Duigou, Alain [CEA/DEN/DANS/I-Tese, Gif-sur-Yvette (France); Quemere, Marie-Marguerite [EDF R et D, Moret sur Loing (France). Dept. EPI; Marion, Pierre [IFP, Rueil Malmaison (FR)] (and others)

    2010-07-01

    The HyFrance Group was originally formed in France to support the European project HyWays, by providing (former projects HyFrance1 and HyFrance2) the French data and possible hydrogen pathways according to national specificities. HyFrance3 is a new project that focuses on the economic competitiveness of different steps of the hydrogen chain, from the production to end usage, at the time horizon of 2030 in France. The project is coordinated by CEA with the other partners being: ADEME (co-funding), AFH2, CNRS, IFP, Air Liquide, EdF, GdF Suez, TOTAL, ALPHEA. The project is divided into 4 sub-projects, that address present and future French hydrogen industrial markets for chemical and refinery uses, the analysis of the interplay between wind energy production and storage of hydrogen for different automotive requirements (refuelling stations, BtL plants, H2/NG mix), massive hydrogen storage to balance various offer and demand characteristics, and the supply network (pipeline option competitiveness vs. trucked in supply) to distribute hydrogen in a French region for automotive applications. Technical and economical issues, as well as GHG emissions, are addressed. (orig.)

  1. Goal-Directed Resuscitation Aiming Cardiac Index Masks Residual Hypovolemia: An Animal Experiment

    Directory of Open Access Journals (Sweden)

    Krisztián Tánczos

    2015-01-01

    Full Text Available The aim of this study was to compare stroke volume (SVI to cardiac index (CI guided resuscitation in a bleeding-resuscitation experiment. Twenty six pigs were randomized and bled in both groups till baseline SVI (Tbsl dropped by 50% (T0, followed by resuscitation with crystalloid solution until initial SVI or CI was reached (T4. Similar amount of blood was shed but animals received significantly less fluid in the CI-group as in the SVI-group: median = 900 (interquartile range: 850–1780 versus 1965 (1584–2165 mL, p=0.02, respectively. In the SVI-group all variables returned to their baseline values, but in the CI-group animals remained underresuscitated as indicated by SVI, heart rate (HR and stroke volume variation (SVV, and central venous oxygen saturation (ScvO2 at T4 as compared to Tbsl: SVI = 23.8 ± 5.9 versus 31.4 ± 4.7 mL, HR: 117 ± 35 versus 89 ± 11/min SVV: 17.4 ± 7.6 versus 11.5 ± 5.3%, and ScvO2: 64.1 ± 11.6 versus 79.2 ± 8.1%, p<0.05, respectively. Our results indicate that CI-based goal-directed resuscitation may result in residual hypovolaemia, as bleeding caused stress induced tachycardia “normalizes” CI, without restoring adequate SVI. As the SVI-guided approach normalized most hemodynamic variables, we recommend using SVI instead of CI as the primary goal of resuscitation during acute bleeding.

  2. [The tasks and aims of hospital psychiatry today and in the future].

    Science.gov (United States)

    Honig, A; Sierink, D; Verwey, B

    Care provided by consultation-liaison (CL) psychiatry and general hospital (GH) psychiatry varies widely. This means that certain services are almost unrecognisable and therefore less readily available to patients. AIM: To describe the core tasks of current CL- and GH-psychiatry care and to suggest how these tasks can best be performed and developed in the future. METHOD: We conducted a selective review of relevant CL- and GH-related literature and combined the information we obtained with the results of a consultation with CL-psychiatrists about how CL- and GL psychiatry should function in the future. RESULTS: Core tasks of CL- and GH-psychiatry are: 1. inpatient and outpatient care for complex patients with combined somatic and psychiatric problems (including addiction) and 2. acute care, diagnosis and treatment of patients referred to the Emergency Department. We gave an outline of how the quality of training can be maintained and/or improved and we suggest ways in which the funding of CL- and GH-psychiatry can be safeguarded and, if possible, increased in the future. CONCLUSION: We strongly recommend that large teaching hospitals and all university hospitals should have at their disposal a psychiatric consultation service that includes psychiatric Emergency Department facilities and specialised CL and GH inpatient and outpatient facility such as a medical-psychiatric unit. The CL- and GH-service should have a psychiatrist as gatekeeper and should be integrated into the hospital's chain of care. Partners in this chain of care are interns who have other medical specialisms, mental health specialists employed at other (mainly psychiatric) hospitals and general practitioners (GPs).

  3. Compliance with self-regulation of television food and beverage advertising aimed at children in Spain.

    Science.gov (United States)

    Romero-Fernández, Ma Mar; Royo-Bordonada, Miguel Angel; Rodríguez-Artalejo, Fernando

    2010-07-01

    To evaluate the level of compliance with the PAOS Code (Publicidad, Actividad, Obesidad y Salud), which establishes standards for the self-regulation of food marketing aimed at minors, in television advertising by food and beverage companies that have agreed to abide by the Code. The study sample consisted of food and beverage advertisements targeting children during 80 h of programming by four Spanish television networks. The level of compliance with each standard of the PAOS Code was classified into three categories: 'compliance', 'non-compliance' and 'uncertain compliance'. Overall, an advertisement was considered compliant with the PAOS Code if it met all the standards; non-compliant if it contravened one or more standards; and uncertain in all other cases. Of a total of 203 television advertisements from companies that agreed to the PAOS Code, the overall prevalence of non-compliance was 49.3% (v. 50.8% among those that did not agree to the code), with 20.7% of advertisements considered of uncertain compliance. Non-compliance was more frequent on Saturdays, in longer advertisements, in advertisements containing promotions or dairy products, and for advertisements from companies of French or US origin. Non-compliance with the PAOS Code was very high and was similar for companies that did and did not agree to the Code, casting doubt on the Code's effectiveness and oversight system. It seems the time has come to commit to statutory regulations that reduce the negative impact of advertising on children's diets, as demanded by public health experts and consumer associations.

  4. Minimal disturbance : Ensign's ADR-1000-CT rig aimed at CBM market

    International Nuclear Information System (INIS)

    Roche, P.

    2005-01-01

    Ensign Resource Services Group Inc. has recently designed a light, mobile rig aimed at Western Canada's coalbed methane (CBM) market. With a 1000 metre depth rating, the automated ADR-1000-CT rig can drill with either jointed pipe or 3 and a half-inch coil. Tractor units are used to move the rig to avoid the extra traffic generated by third-party trucks. The rig's self-levelling capability creates less environmental disturbance. Each component works on sites with as much as 2 metres difference in elevation, which reduces the need for earth-moving equipment. As drilling moves closer to farms and acreages, minimal environmental disturbance is crucial to the CBM industry. The rig won a 2005 Alberta government award for innovations in workplace health and safety as the design eliminates many of the tasks where injuries occur on conventional rigs. On conventional rigs, drill-strings are suspended from a travelling block which is suspended from the crown of a large, heavy derrick. With the ADR, hydraulic cylinders bear the weight of the drill string, and the derrick serves mainly to guide the top drive. When drilling only with jointed pipe, the coiled-tubing reel is a separate load so that drilling crews don't have to transport it around on programs requiring only jointed pipe. If coil is needed, the reel can be trucked to the site and plugged in to the rest of the rig. Tubing is expected to last 3 times as long as on a regular coiled-tubing rig, as the reel is positioned directly over the rotary table. The rigs have been used for various drilling projects and have performed satisfactorily with high penetration rates due to their large mud pumps. It was concluded that the ADR-1000-CT rig's hydraulic self-levelling capability and agility are helpful features when drilling in a minimal disturbance environment. 3 figs

  5. Preparation of transfersomes encapsulating sildenafil aimed for transdermal drug delivery: Plackett-Burman design and characterization.

    Science.gov (United States)

    Ahmed, Tarek A

    2015-03-01

    The aim of this work was to study the effect of different processing and formulation parameters on the preparation of sildenafil (SD) transfersomes utilizing the Plackett-Burman design. The drug to phospholipid molar ratio (X1), phospholipid to surfactant ratio (X2), hydrophilic-lipophilic balance of the surfactant (X3), hydration medium pH (X4), hydration time (X5) and the temperature of hydration (X6) were investigated to study their effect on the vesicle size (Y1) and entrapment efficiency (EE) of the drug (Y2). The preparation conditions were optimized to minimize the vesicle size and maximize the EE. The prepared transfersomes were also subjected to zeta potential measurements, morphological and physicochemical characterization. The combinations of factors that achieve the optimum desirability were identified. An optimized formulation was prepared and characterized once more for its vesicle size, EE, in vitro permeation and deformability index. The results revealed that both X3 and X6 had a pronounced effect on Y1, while X1 and X4 showed a significant effect on Y2. Morphological and physicochemical study confirmed the transfersomes spherical shape and compatibility of the formulation ingredients. The formulation with optimum desirability showed EE and vesicle size of 97.21% and 610 nm, respectively. In vitro permeation of the drug-loaded transfersome showed more than 5-fold higher permeation rate compared with drug suspension. Deformability index verified elasticity of the preparation. The significant variables could be optimized again to produce smaller vesicle size that could increase SD permeation from transdermal delivery systems loaded drug optimized transfersomes.

  6. Thermodynamic analysis of engineering solutions aimed at raising the efficiency of integrated gasification combined cycle

    Science.gov (United States)

    Gordeev, S. I.; Bogatova, T. F.; Ryzhkov, A. F.

    2017-11-01

    Raising the efficiency and environmental friendliness of electric power generation from coal is the aim of numerous research groups today. The traditional approach based on the steam power cycle has reached its efficiency limit, prompted by materials development and maneuverability performance. The rival approach based on the combined cycle is also drawing nearer to its efficiency limit. However, there is a reserve for efficiency increase of the integrated gasification combined cycle, which has the energy efficiency at the level of modern steam-turbine power units. The limit of increase in efficiency is the efficiency of NGCC. One of the main problems of the IGCC is higher costs of receiving and preparing fuel gas for GTU. It would be reasonable to decrease the necessary amount of fuel gas in the power unit to minimize the costs. The effect can be reached by raising of the heat value of fuel gas, its heat content and the heat content of cycle air. On the example of the process flowsheet of the IGCC with a power of 500 MW, running on Kuznetsk bituminous coal, by means of software Thermoflex, the influence of the developed technical solutions on the efficiency of the power plant is considered. It is received that rise in steam-air blast temperature to 900°C leads to an increase in conversion efficiency up to 84.2%. An increase in temperature levels of fuel gas clean-up to 900°C leads to an increase in the IGCC efficiency gross/net by 3.42%. Cycle air heating reduces the need for fuel gas by 40% and raises the IGCC efficiency gross/net by 0.85-1.22%. The offered solutions for IGCC allow to exceed net efficiency of analogous plants by 1.8-2.3%.

  7. The Australian national reactive phosphate rock project - Aims, experimental approach, and site characteristics

    International Nuclear Information System (INIS)

    McLaughlin, M.J.

    2002-01-01

    generated. The aims, rationale and methods used for the experiments across the network are presented and discussed. (author)

  8. Dental Faculty Members' Pedagogic Beliefs and Curriculum Aims in Problem-Based Learning: An Exploratory Study.

    Science.gov (United States)

    von Bergmann, HsingChi; Walker, Judith; Dalrymple, Kirsten R; Shuler, Charles F

    2017-08-01

    The aims of this exploratory study were to explore dental faculty members' views and beliefs regarding knowledge, the dental profession, and teaching and learning and to determine how these views related to their problem-based learning (PBL) instructional practices. Prior to a PBL in dental education conference held in 2011, all attendees were invited to complete a survey focused on their pedagogical beliefs and practices in PBL. Out of a possible 55 participants, 28 responded. Additionally, during the conference, a forum was held in which preliminary survey findings were shared and participants contributed to focus group data collection. The forum results served to validate and bring deeper understanding to the survey findings. The conference participants who joined the forum (N=32) likely included some or many of the anonymous respondents to the survey, along with additional participants interested in dental educators' beliefs. The findings of the survey and follow-up forum indicated a disconnect between dental educators' reported views of knowledge and their pedagogical practices in a PBL environment. The results suggested that the degree of participants' tolerance of uncertainty in knowledge and the discrepancy between their epistemological and ontological beliefs about PBL pedagogy influenced their pedagogical choices. These findings support the idea that learner-centered, inquiry-based pedagogical approaches such as PBL may create dissonance between beliefs about knowledge and pedagogical practice that require the building of a shared understanding of and commitment to curricular goals prior to implementation to ensure success. The methods used in this study can be useful tools for faculty development in PBL programs in dental education.

  9. Advanced emission control system: CO2 sequestration using algae integrated management system (AIMS)

    International Nuclear Information System (INIS)

    Syed Isa Syed Alwi; Mohd Norsham Che Yahya; Ruzanna Abdul Rahman

    2010-01-01

    One of the companies under Algae tech, Sasaran Bio fuel Sdn. Bhd. provides project management, technology transfer and technical expertise to develop a solution to minimize and mitigate Carbon Dioxide (CO 2 ) emissions through the diversion of the CO 2 to open algal ponds and enclosed photo-bioreactors as algal propagation technologies to consume CO 2 waste stream. The company is presently consulting a listed company from Indonesia to address the technology know-how and implementation of microalgae development from the flue gas of the Groups power plants. Nowadays, one of the aspects that contribute to the air pollution is the emission of flue gases from the factories. So, we provide a system that can reduce the emission of flue gas to the atmosphere and at the same time, cultivate certain strain of algae. With the technology, Algae Integrated Management System (AIMS), it will be for sure a new beginning for way to reduce air pollution. The utilization of power plant resources for growing selected microalgae at a low energy cost for valuable products and bio-fuels while providing CO 2 sequestering. In the same time, it also a low cost algae agriculture. By doing so, it provides all year algae production which can be an income. This residual energy used CO 2 produced from power stations and industrial plants to feed the process (CO 2 recycling and bio-fixation) in cultivation of algae. This will be a low cost flue gas (CO 2 ) to the developer. In a nutshell, CO 2 Sequestration by algae reactors is a potential to reduce greenhouse gas emission by using the CO 2 in the stack gases to produce algae. (author)

  10. Prevalence of rheumatic diseases in adult population in Spain (EPISER 2016 study): Aims and methodology.

    Science.gov (United States)

    Seoane-Mato, Daniel; Sánchez-Piedra, Carlos; Silva-Fernández, Lucía; Sivera, Francisca; Blanco, Francisco J; Pérez Ruiz, Fernando; Juan-Mas, Antonio; Pego-Reigosa, José M; Narváez, Javier; Quilis Martí, Neus; Cortés Verdú, Raúl; Antón-Pagés, Fred; Quevedo Vila, Víctor; Garrido Courel, Laura; Del Amo, Natividad Del Val; Paniagua Zudaire, Inmaculada; Añez Sturchio, Gustavo; Medina Varo, Fermín; Ruiz Tudela, María Del Mar; Romero Pérez, Antonio; Ballina, Javier; Brandy García, Anahy; Fábregas Canales, Dolores; Font Gayá, Teresa; Bordoy Ferrer, Carolina; González Álvarez, Beatriz; Casas Hernández, Laura; Álvarez Reyes, Fátima; Delgado Sánchez, Mónica; Martínez Dubois, Cristina; Sánchez-Fernández, Simón Ángel; Rojas Vargas, Luisa Marena; García Morales, Paula Virginia; Olivé, Alejandro; Rubio Muñoz, Paula; Larrosa, Marta; Navarro Ricos, Noemí; Graell Martín, Eduard; Chamizo, Eugenio; Chaves Chaparro, Lara; Rojas Herrera, Sara; Pons Dolset, Jordi; Polo Ostariz, Miguel Ángel; Ruiz-Alejos Garrido, Susana; Macía Villa, Cristina; Cruz Valenciano, Ana; González Gómez, María Luisa; Morcillo Valle, Mercedes; Palma Sánchez, Deseada; Moreno Martínez, María José; Mayor González, Marta; Atxotegi Sáenz de Buruaga, Joana; Urionagüena Onaindia, Irati; Blanco Cáceres, Boris Anthony; Díaz-González, Federico; Bustabad, Sagrario

    2017-07-31

    To describe the methodology of the EPISER 2016 (study of the prevalence of rheumatic diseases in adult population in Spain), as well its strengths and limitations. The aim of this study is to estimate the prevalence of rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), osteoarthritis (knee, hip, hands, and cervical and lumbar spine), fibromyalgia, gout and clinical osteoporotic fracture. Population-based, multicenter, cross-sectional study, with the participation of 45 municipalities in the 17 Spanish autonomous communities. The reference population will consist of adults aged 20 years and over residing in Spain. A computer-assisted telephone interview (CATI) system will be used for data collection. Diagnostic suspicions and diagnoses received by the participants will be studied by rheumatologists in the referral hospitals in the selected municipalities. the prevalence of the rheumatic diseases will be calculated using estimators and their 95% confidence intervals. Weights will be calculated in each of the sampling stages in accordance with the probability of selection. The distribution of the population in Spain will be obtained from the Spanish Statistics Institute. Sociodemographic and lifestyle changes over the last 16 years justify EPISER 2016. This study will provide current data about the prevalences of RA, AS, PsA, SLE, SS, osteoarthritis, fibromyalgia, gout and clinical osteoporotic fracture. The results will allow comparisons with studies from other countries and EPISER 2000. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

  11. Evaluation of a workplace intervention to promote commuter cycling: a RE-AIM analysis.

    Science.gov (United States)

    Dubuy, Veerle; De Cocker, Katrien; De Bourdeaudhuij, Ilse; Maes, Lea; Seghers, Jan; Lefevre, Johan; De Martelaer, Kristine; Cardon, Greet

    2013-06-17

    Originating from the interdisciplinary collaboration between public health and the transportation field a workplace intervention to promote commuter cycling, 'Bike to Work: cyclists are rewarded', was implemented. The intervention consisted of two cycling contests, an online loyalty program based on earning 'cycling points' and the dissemination of information through folders, newsletters, posters and a website. The study purpose was to evaluate the dissemination efforts of the program and to gain insights in whether free participation could persuade small and middle-sized companies to sign up. The RE-AIM framework was used to guide the evaluation. Two months after the start of the intervention a questionnaire was send to 4880 employees. At the end of the intervention each company contact person (n = 12) was interviewed to obtain information on adoption, implementation and maintenance.Comparison analyses between employees aware and unaware of the program were conducted using independent-samples t-tests for quantitative data and chi-square tests for qualitative data. Difference in commuter cycling frequency was assessed using an ANOVA test. Non-parametric tests were used for the comparison analyses between the adopting and non-adopting companies. In total seven of the twelve participating companies adopted the program and all adopting companies implemented all intervention components. No significant differences were found in the mean number of employees (p = 0.15) or in the type of business sector (p = 0.92) between adopting and non-adopting companies. Five out of seven companies had the intention to continue the program. At the individual level, a project awareness of 65% was found. Employees aware of the program had a significantly more positive attitude towards cycling and reported significantly more commuter cycling than those unaware of the program (both p sustainability of the intervention is needed.

  12. Reevaluation of microplastics extraction efficiency with the aim of Munich Plastic Sediment Separator.

    Science.gov (United States)

    Zobkov, Mikhail; Esiukova, Elena; Grave, Aleksei; Khatmullina, Liliya

    2017-04-01

    Invading of microplastics into marine environment is known as a global ecological threat. Specific density of microplastics can vary significantly depending on a polymer type, technological processes of its production, additives, weathering, and biofouling. Plastic particles can sink or float on the sea surface, but with time, most of drifting plastics become negatively buoyant and sink to the sea floor due to biofouling or adherence of denser particles. As a result, the seabed becomes the ultimate repository for microplastic particles and fibres. A study of microplastics content in aquatic sediments is an important source of information about ways of their migration, sink and accumulation zones. The Munich Plastic Sediment Separator (MPSS), proposed by Imhoff et al. (2012), is considered as the most effective tool for microplastic extraction. However, we observed that the numbers of marine microplastics extracted with this tool from different kinds of bottom sediments were significantly underestimated. We examined the extraction efficiency of the MPSS by adding artificial reference particles (ARPs) to marine sediment sample before the extraction procedure. Extraction was performed by two different methods: the modified NOAA method and using the MPSS. The separation solution with specific density 1.5 g/ml was used. Subsequent cleaning, drying and microscope detection procedures were identical. The microplastics content was determined in supernatant fraction, in the bulk of the extraction solution, in spoil dump fraction of MPSS and in instrument wash-out. While the extraction efficiency from natural sediments of ARPs by the MPSS was really high (100% in most cases), the extraction efficiency of marine microplastics was up to 10 times lower than that obtained with modified NOAA method for the same samples. Less than 40% of the total marine microplastics content has been successfully extracted with the MPSS. Large amounts of marine microplastics were found in the

  13. [Dermatomyositis-specific antibodies].

    Science.gov (United States)

    Bodoki, L; Nagy-Vincze, M; Griger, Z; Dankó, K

    2015-05-01

    Idiopathic inflammatory myopathies are chronic systemic autoimmune diseases characterized by symmetrical proximal muscle weakness. The clinicopathological subdivision nowadays appears to be obsolete which is why the immunoserological classification has been developed. Dermatomyositis represents one the most important subsets of idiopathic inflammatory myopathy and dermatomyositis-specific autoantibodies play a significant role in this subset. The aim of this article was to present these autoantibodies with the help of the literature. This article presents the most important information about dermatomyositis including not only the classical anti-Mi-2 autoantibody but also the recently detected anti-TIF1γ, anti-NXP2, anti-SAE and anti-MDA5 autoantibodies. The focus is on the frequency of these autoantibodies, the associated symptoms in adult and juvenile dermatomyositis cases and some special aspects from the literature. All of the studies confirmed that these autoantibodies are particularly detectable in dermatomyositis. The results from the literature have recently shown that the frequency of the autoantibodies detected in juvenile cases is higher than the frequency of traditional autoantibodies (e.g. anti-Jo-1, anti-Mi-2 and anti-SRP). It is useful to detect these autoantibodies in order to be able to make a better assessment of the clinical symptoms and prognosis during the course of the disease.

  14. Defining indicators to motorize block valves aiming to reduce potential leakage applied to OSBRA pipeline

    Energy Technology Data Exchange (ETDEWEB)

    Pires, L.F.G. [Pontificia Universidade Catolica do Rio de Janeiro (PUC-Rio), RJ (Brazil); Sousa, A.G.; Castro, N.C.; Spagnolo, R. [Petrobras Transporte S.A. (TRANSPETRO), Rio de Janeiro, RJ (Brazil)

    2009-07-01

    The discussion about motorizing block valves is a constant point being brought up when it is intended to control or reduce the amount of liquid leaking in the event of a pipe rupture. During the pipeline's project stage the installation of blocking valves along the pipeline must be taken into consideration to meet the operation and maintenance requirements as well as to reduce the potential amounts of volume being leaked. In existing pipelines, the main concern is the definition of which valves are candidates to be motorized. In both situations criteria should be established to define this choice. A math algorithm was developed to define the potential leakage due to gravity along the pipeline profile where the influence of a valve over another is verified, as well as the contribution of the check valves existing in the pipeline. The present work defines a parameter based on the extension protected by the valve and the reduction of the potential leakage. This parameter is then fed to a worksheet where the efficiency indicators are calculated to each valve eligible to be motorized. It also takes into consideration factors relative to the valve location, such as the environmental sensitivity, risk assessment, social diagnosis and device's proximity to contingency resources. Finally, after considering all the above aspects, it's possible to come up with a final classification, recommending specific valves to be prioritized on an eventual process of motorization adequacies. This methodology was applied, experimentally on a pipe segment of TRANSPETRO's Sao Paulo-Brasilia pipeline - OSBRA , where it proved to be an important technological and management tool. (author)

  15. The Economic Activity Rate of the Romanian Population. Status and Aims

    Directory of Open Access Journals (Sweden)

    MARIA SIMION

    2012-03-01

    Full Text Available The lack of balance of national budgets and, in particular, of the social security budget, makes decision makers to look increasingly to the characteristics of the labour market and to the general output of economic activity. The better a country is placed in terms of the technological performance of economic activities, which favours an increased labour productivity, the higher are the values of the gross domestic product of the state's general income, and the country's possibility to afford a social policy that is more adapted to the needs of the population. Innovation performance classifies EU member states into four groups, each of these groups having almost a specific curve of the participation rates according to age and sex. In Romania, the population's activity rates according to age groups in the more developed regions are closer to those in the countries with the best innovation performance, although, as a whole, Romania is placed in the fourth and last group according to innovation results among EU member states. In our country, the activity rates according to age group have decreased in recent years, especially with respect to groups aged 50 or more, although the retirement age for men is the highest among EU countries. The increase of labour productivity has boosted economic growth in the recent past but, because of the lack of coherent economic policies, this growth has not. In Romania, activity rates for certain age groups were higher three decades ago and even in the first years of the transition to the market economy. Several scenarios for the projection of rates of participation to economic life until 2020, according to age groups are useful - and, possibly, also realistic, even if the (optimistic scenario with the highest activity rates is taken into account. The latter could be achieved if policies are implemented which enable workforce retention in the country and a better match between the qualification level and profile and

  16. A systematic review of economic evaluations assessing interventions aimed at preventing or treating pressure ulcers.

    Science.gov (United States)

    Palfreyman, Simon J; Stone, Patricia W

    2015-03-01

    Pressure ulcers have an adverse impact on patients and can also result in additional costs and workload for healthcare providers. Interventions to prevent pressure ulcers are focused on identifying at risk patients and using systems such as mattresses and turning to relieve pressure. Treatments for pressure ulcers are directed towards promoting wound healing and symptom relief. Both prevention and treatments have associated costs for healthcare providers. The aim of this study was to systematically review the economic evidence for prevention and treatment interventions for pressure ulcers. A systematic review of comparative clinical studies that evaluate interventions to either prevent or treat pressure ulcers. Searches of the major electronic databases were conducted to identify citations that reported costs or economic analysis for interventions directed towards prevention or treatment of pressure ulcers. Only comparative clinical studies were included. Review articles, case-series, non-randomised studies, and studies in a foreign language that did not have an abstract in English were excluded from the review. Decisions regarding inclusion or exclusion were based on a consensus of the authors after review of the title or abstract. Potential citations were obtained for more detailed review and assessed against the inclusion criteria. The studies identified for inclusion were assessed against the 24 key criteria contained in the CHEERS checklist. Costs were standardised to US dollars and adjusted for inflation to 2012 rates. The searches identified 105 potential studies. After review of the citations a total of 23 studies were included: 12 examined prevention interventions and 11 treatments. Review against the CHEERS criteria showed that the majority of included trials had poor reporting and a lack of detail regarding how costs were calculated. Few studies reported more than aggregate costs of treatments with only a small number reporting unit cost outcomes

  17. Deep-Sea Mining With No Net Loss of Biodiversity—An Impossible Aim

    Directory of Open Access Journals (Sweden)

    Holly J. Niner

    2018-03-01

    Full Text Available Deep-sea mining is likely to result in biodiversity loss, and the significance of this to ecosystem function is not known. “Out of kind” biodiversity offsets substituting one ecosystem type (e.g., coral reefs for another (e.g., abyssal nodule fields have been proposed to compensate for such loss. Here we consider a goal of no net loss (NNL of biodiversity and explore the challenges of applying this aim to deep seabed mining, based on the associated mitigation hierarchy (avoid, minimize, remediate. We conclude that the industry cannot at present deliver an outcome of NNL. This results from the vulnerable nature of deep-sea environments to mining impacts, currently limited technological capacity to minimize harm, significant gaps in ecological knowledge, and uncertainties of recovery potential of deep-sea ecosystems. Avoidance and minimization of impacts are therefore the only presently viable means of reducing biodiversity losses from seabed mining. Because of these constraints, when and if deep-sea mining proceeds, it must be approached in a precautionary and step-wise manner to integrate new and developing knowledge. Each step should be subject to explicit environmental management goals, monitoring protocols, and binding standards to avoid serious environmental harm and minimize loss of biodiversity. “Out of kind” measures, an option for compensation currently proposed, cannot replicate biodiversity and ecosystem services lost through mining of the deep seabed and thus cannot be considered true offsets. The ecosystem functions provided by deep-sea biodiversity contribute to a wide range of provisioning services (e.g., the exploitation of fish, energy, pharmaceuticals, and cosmetics, play an essential role in regulatory services (e.g., carbon sequestration and are important culturally. The level of “acceptable” biodiversity loss in the deep sea requires public, transparent, and well-informed consideration, as well as wide agreement

  18. Process evaluation of a tailored mobile health intervention aiming to reduce fatigue in airline pilots

    Directory of Open Access Journals (Sweden)

    Alwin van Drongelen

    2016-08-01

    Full Text Available Abstract Background MORE Energy is a mobile health intervention which aims to reduce fatigue and improve health in airline pilots. The primary objective of this process evaluation was to assess the reach, dose delivered, compliance, fidelity, barriers and facilitators, and satisfaction of the intervention. The second objective was to investigate the associations of adherence to the intervention with compliance and with participant satisfaction. Thirdly, we investigated differences between the subgroups within the target population. Methods The intervention consisted of a smartphone application, supported by a website. It provided advice on optimal light exposure, sleep, nutrition, and physical activity, tailored to flight and personal characteristics. The reach of the intervention was determined by comparing the intervention group participants and the airline pilots who did not participate. The dose delivered was defined as the total number of participants that was sent an instruction email. Objective compliance was measured through the Control Management System of the application. To determine the fidelity, an extensive log was kept throughout the intervention period. Subjective compliance, satisfaction, barriers, facilitators, and adherence were assessed using online questionnaires. Associations between the extent to which the participants applied the advice in daily life (adherence, compliance, and satisfaction were analysed as well. Finally, outcomes of participants of different age groups and haul types were compared. Results A total of 2222 pilots were made aware of the study. From this group, 502 pilots met the inclusion criteria and did agree to participate. The reach of the study proved to be 22 % and the dose delivered was 99 %. The included pilots were randomized into the intervention group (n = 251 or the control group (n = 251. Of the intervention group participants, 81 % consulted any advice, while 17 % did this during

  19. Adsorption of lanthanides in aqueous solution aiming to study of nuclear wastes

    International Nuclear Information System (INIS)

    Belline, Jean de Brito

    2009-01-01

    The problem of radioactive wastes is a concern of world-wide scope, a time that does not still have a defined local for the construction of a repository for radioactive wastes of high level. One of the preliminary stages for the choice of the place more appropriate is the geologic study associated to the experimental studies of adsorption of the involved chemical species in the process. In this work, a sample of basaltic rock was used, of the South Region of the Formation Serra Geral, collected in Frederico Westphalen Town (RS), that it will be probably a candidate to the rock hostess for location of radioactive wastes. Two experiments have been carried out through, namely: 'Test Batch' and Percolating, both under atmospheric pressure, at the ambient temperature of 25 deg C, with the purpose to study the capacity of sorption of the rare earth elements - REE. The REE are used in this work in function of its analogy with the actinides, aiming at to investigate the chemistry behavior and the speciation of the same in natural waters, searching the possibility of geologic storage of radioactive wastes, a time that the adsorption of the REE depends on variables of the environment as pH, ionic strength, temperature and presence of ligands, as carbonates and constituent of surfaces of minerals. Experiment of percolating of the REE was carried through, 100ppb, in the basalt (with 80 mesh) in solutions with ionic strength 1= 0,025 M and 1=0,5 M of NaCl. pH was controlled in a range of 5,6 the 7,6 with HNO 3 addition. The concentrations were analyzed by ICP-MS. The 'Batch Test' is an efficient form of studying sorption/desorption isotherms, beyond values of the reason between the distributions solid/solution and estimation of the solubility. The percolating experiment, was carried through under pH controlled around 6, and allowed to verify the behaviour of heavy REE in comparison with the light REE. (author)

  20. Value of Information Analysis Applied to the Economic Evaluation of Interventions Aimed at Reducing Juvenile Delinquency: An Illustration.

    Directory of Open Access Journals (Sweden)

    Hester V Eeren

    Full Text Available To investigate whether a value of information analysis, commonly applied in health care evaluations, is feasible and meaningful in the field of crime prevention.Interventions aimed at reducing juvenile delinquency are increasingly being evaluated according to their cost-effectiveness. Results of cost-effectiveness models are subject to uncertainty in their cost and effect estimates. Further research can reduce that parameter uncertainty. The value of such further research can be estimated using a value of information analysis, as illustrated in the current study. We built upon an earlier published cost-effectiveness model that demonstrated the comparison of two interventions aimed at reducing juvenile delinquency. Outcomes were presented as costs per criminal activity free year.At a societal willingness-to-pay of €71,700 per criminal activity free year, further research to eliminate parameter uncertainty was valued at €176 million. Therefore, in this illustrative analysis, the value of information analysis determined that society should be willing to spend a maximum of €176 million in reducing decision uncertainty in the cost-effectiveness of the two interventions. Moreover, the results suggest that reducing uncertainty in some specific model parameters might be more valuable than in others.Using a value of information framework to assess the value of conducting further research in the field of crime prevention proved to be feasible. The results were meaningful and can be interpreted according to health care evaluation studies. This analysis can be helpful in justifying additional research funds to further inform the reimbursement decision in regard to interventions for juvenile delinquents.

  1. The effect of interventions aiming to optimise the prescription of antibiotics in dental care-A systematic review.

    Science.gov (United States)

    Löffler, Christin; Böhmer, Femke

    2017-01-01

    Abundant evidence in dentistry suggests that antibiotics are prescribed despite the existence of guidelines aiming to reduce the development of antibiotic resistance. This review investigated (1) which type of interventions aiming to optimise prescription of antibiotics exist in dentistry, (2) the effect of these interventions and (3) the specific strengths and limitations of the studies reporting on these interventions. Literature search was based on Medline, Embase, Global Health, Cochrane CENTRAL, ClinicalTrials.gov and Current Controlled Trials. Studies with one of the two primary outcomes were included: (1) The number of antibiotics prescribed and/or (2) the accuracy of the prescription, commonly measured as a percentage of adherence to local clinical guidelines. Nine studies met these inclusion criteria. Five studies reported on the prescription of antibiotics in primary dental care and four studies focused on outpatient dental care. Interventions used in primary dental care included a combination of audit, feedback, education, local consensus, dissemination of guidelines and/or academic detailing. Trials in the outpatient setting made use of expert panel discussions, educational feedback on previous acts of prescribing, the dissemination of guidelines and the establishment of internal guidelines. All studies successfully reduced the number of antibiotics prescribed and/or increased the accuracy of the prescription. However, most studies were confounded by a high risk of selection bias, selective outcome reporting and high variance across study groups. In particular, information relating to study design and methodology was insufficient. Only three studies related the prescriptions to the number of patients treated with antibiotics. This systematic review was able to offer conclusions which took the limitations of the investigated studies into account. Unfortunately, few studies could be included and many of these studies were confounded by a low quality of

  2. The effect of interventions aiming to optimise the prescription of antibiotics in dental care—A systematic review

    Science.gov (United States)

    Böhmer, Femke

    2017-01-01

    Background Abundant evidence in dentistry suggests that antibiotics are prescribed despite the existence of guidelines aiming to reduce the development of antibiotic resistance. This review investigated (1) which type of interventions aiming to optimise prescription of antibiotics exist in dentistry, (2) the effect of these interventions and (3) the specific strengths and limitations of the studies reporting on these interventions. Method Literature search was based on Medline, Embase, Global Health, Cochrane CENTRAL, ClinicalTrials.gov and Current Controlled Trials. Studies with one of the two primary outcomes were included: (1) The number of antibiotics prescribed and/or (2) the accuracy of the prescription, commonly measured as a percentage of adherence to local clinical guidelines. Results Nine studies met these inclusion criteria. Five studies reported on the prescription of antibiotics in primary dental care and four studies focused on outpatient dental care. Interventions used in primary dental care included a combination of audit, feedback, education, local consensus, dissemination of guidelines and/or academic detailing. Trials in the outpatient setting made use of expert panel discussions, educational feedback on previous acts of prescribing, the dissemination of guidelines and the establishment of internal guidelines. All studies successfully reduced the number of antibiotics prescribed and/or increased the accuracy of the prescription. However, most studies were confounded by a high risk of selection bias, selective outcome reporting and high variance across study groups. In particular, information relating to study design and methodology was insufficient. Only three studies related the prescriptions to the number of patients treated with antibiotics. Conclusions This systematic review was able to offer conclusions which took the limitations of the investigated studies into account. Unfortunately, few studies could be included and many of these studies

  3. The effect of interventions aiming to optimise the prescription of antibiotics in dental care-A systematic review.

    Directory of Open Access Journals (Sweden)

    Christin Löffler

    Full Text Available Abundant evidence in dentistry suggests that antibiotics are prescribed despite the existence of guidelines aiming to reduce the development of antibiotic resistance. This review investigated (1 which type of interventions aiming to optimise prescription of antibiotics exist in dentistry, (2 the effect of these interventions and (3 the specific strengths and limitations of the studies reporting on these interventions.Literature search was based on Medline, Embase, Global Health, Cochrane CENTRAL, ClinicalTrials.gov and Current Controlled Trials. Studies with one of the two primary outcomes were included: (1 The number of antibiotics prescribed and/or (2 the accuracy of the prescription, commonly measured as a percentage of adherence to local clinical guidelines.Nine studies met these inclusion criteria. Five studies reported on the prescription of antibiotics in primary dental care and four studies focused on outpatient dental care. Interventions used in primary dental care included a combination of audit, feedback, education, local consensus, dissemination of guidelines and/or academic detailing. Trials in the outpatient setting made use of expert panel discussions, educational feedback on previous acts of prescribing, the dissemination of guidelines and the establishment of internal guidelines. All studies successfully reduced the number of antibiotics prescribed and/or increased the accuracy of the prescription. However, most studies were confounded by a high risk of selection bias, selective outcome reporting and high variance across study groups. In particular, information relating to study design and methodology was insufficient. Only three studies related the prescriptions to the number of patients treated with antibiotics.This systematic review was able to offer conclusions which took the limitations of the investigated studies into account. Unfortunately, few studies could be included and many of these studies were confounded by a low

  4. European network for promoting the physical health of residents in psychiatric and social care facilities (HELPS: background, aims and methods

    Directory of Open Access Journals (Sweden)

    Marginean Roxana

    2009-08-01

    Full Text Available Abstract Background People with mental disorders have a higher prevalence of physical illnesses and reduced life expectancy as compared with the general population. However, there is a lack of knowledge across Europe concerning interventions that aim at reducing somatic morbidity and excess mortality by promoting behaviour-based and/or environment-based interventions. Methods and design HELPS is an interdisciplinary European network that aims at (i gathering relevant knowledge on physical illness in people with mental illness, (ii identifying health promotion initiatives in European countries that meet country-specific needs, and (iii at identifying best practice across Europe. Criteria for best practice will include evidence on the efficacy of physical health interventions and of their effectiveness in routine care, cost implications and feasibility for adaptation and implementation of interventions across different settings in Europe. HELPS will develop and implement a "physical health promotion toolkit". The toolkit will provide information to empower residents and staff to identify the most relevant risk factors in their specific context and to select the most appropriate action out of a range of defined health promoting interventions. The key methods are (a stakeholder analysis, (b international literature reviews, (c Delphi rounds with experts from participating centres, and (d focus groups with staff and residents of mental health care facilities. Meanwhile a multi-disciplinary network consisting of 15 European countries has been established and took up the work. As one main result of the project they expect that a widespread use of the HELPS toolkit could have a significant positive effect on the physical health status of residents of mental health and social care facilities, as well as to hold resonance for community dwelling people with mental health problems. Discussion A general strategy on health promotion for people with mental

  5. European network for promoting the physical health of residents in psychiatric and social care facilities (HELPS): background, aims and methods

    Science.gov (United States)

    Weiser, Prisca; Becker, Thomas; Losert, Carolin; Alptekin, Köksal; Berti, Loretta; Burti, Lorenzo; Burton, Alexandra; Dernovsek, Mojca; Dragomirecka, Eva; Freidl, Marion; Friedrich, Fabian; Genova, Aneta; Germanavicius, Arunas; Halis, Ulaş; Henderson, John; Hjorth, Peter; Lai, Taavi; Larsen, Jens Ivar; Lech, Katarzyna; Lucas, Ramona; Marginean, Roxana; McDaid, David; Mladenova, Maya; Munk-Jørgensen, Povl; Paziuc, Alexandru; Paziuc, Petronela; Priebe, Stefan; Prot-Klinger, Katarzyna; Wancata, Johannes; Kilian, Reinhold

    2009-01-01

    Background People with mental disorders have a higher prevalence of physical illnesses and reduced life expectancy as compared with the general population. However, there is a lack of knowledge across Europe concerning interventions that aim at reducing somatic morbidity and excess mortality by promoting behaviour-based and/or environment-based interventions. Methods and design HELPS is an interdisciplinary European network that aims at (i) gathering relevant knowledge on physical illness in people with mental illness, (ii) identifying health promotion initiatives in European countries that meet country-specific needs, and (iii) at identifying best practice across Europe. Criteria for best practice will include evidence on the efficacy of physical health interventions and of their effectiveness in routine care, cost implications and feasibility for adaptation and implementation of interventions across different settings in Europe. HELPS will develop and implement a "physical health promotion toolkit". The toolkit will provide information to empower residents and staff to identify the most relevant risk factors in their specific context and to select the most appropriate action out of a range of defined health promoting interventions. The key methods are (a) stakeholder analysis, (b) international literature reviews, (c) Delphi rounds with experts from participating centres, and (d) focus groups with staff and residents of mental health care facilities. Meanwhile a multi-disciplinary network consisting of 15 European countries has been established and took up the work. As one main result of the project they expect that a widespread use of the HELPS toolkit could have a significant positive effect on the physical health status of residents of mental health and social care facilities, as well as to hold resonance for community dwelling people with mental health problems. Discussion A general strategy on health promotion for people with mental disorders must take into

  6. FUSELAGE SHAPE OPTIMIZATION AIMED AT WING-FUSELAGE CONFIGURATION DRAG REDUCTION AT SUPERSONIC SPEEDS

    Directory of Open Access Journals (Sweden)

    2016-01-01

    specific grotto in the lower part of the fuselage - the constriction from the sides with continuing height growth. The nose part of the optimal fuselage is widened, has a triangular shape in the top view and is deflected down.

  7. National organic standards for Iran: I. Concepts, principles and aims of organic production and standards for agronomic and horticultural products

    Directory of Open Access Journals (Sweden)

    Reza Ghorbani

    2016-04-01

    Full Text Available Traditional agriculture and non-chemical crop production have a long story; however organic agriculture which relies on local and in-farm inputs, with the aim of protecting ecological balances and developing biological cycles on the one hand while regarding regulations and specific standards on the other hand, doesn’t have a very long history. There are numerous environmental reasons for the priority of organic agriculture to conventional systems such as increasing biodiversity, reducing chemical residue in plant and animal products, reducing greenhouse gases and air temperatures; and socio-economic factors like equity and sustainability. Worldwide, in 2006 about 31 million hectares were managed organically with estimated international sales of over 38 billion US dollars. There are very specific standards, regulations and criteria for organic agriculture for the security of producers and consumers, suitable competition between producers and clear regulations for international trades of organic products. Standards in organic agriculture are principles, regulations and criteria that must be considered from production up to processing and consumption. Although Iran has a very long history in agriculture and a variety of cereals and pulses have been domesticated in its regions, unfortunately, there are no organic production plans and standards for this country. During these recent years, there have been international interests especially on behalf of European countries towards exporting some organic products such as pistachio, walnut, date, fresh fruits and saffron from Iran, but the main reason for the refusal of our products could be the absence of organic standards which are to be considered during the production of those products. The present paper recommends the principles and standards, considering IFOAM standards for organic plant products in Iran.

  8. Processing and surface modification of novel natural-origin architectures aimed for biomedical applications

    Science.gov (United States)

    Silva, Simone dos Santos

    In the last decades, tissue engineering has emerged as a potential therapeutical tool aimed at developing substitutes that are able to restore proper function of the damaged organs/tissues. Nature-inspired routes involving natural origin polymer-based systems represent an attractive alternative to produce novel materials by mimicking the tissue environment required for tissue regeneration. Moreover, further modifications of these systems allow the adjustment of their properties in accordance with the requirements for successful biomedical applications. The main goal of the present thesis is to develop and modify natural origin polymer-based systems using simple methodologies such as sol-gel, surface modification by means of plasma treatment and blending of chitosan with proteins (soy protein isolate and silk fibroin). A sol-gel method was used to improve the bulk properties of chitosan by the incorporation of an inorganic component at the sub-nanometric level. Chitosan/siloxane hybrid materials were synthesised, where essentially urea bridges covalently bond the chitosan to the polysiloxane network. These bifunctional materials exhibit interesting photoluminescence features and a bioactive behaviour. In most situations in the biomedical field, the surface of a biomaterial is in direct contact with living tissues. Therefore, the surface characteristics play a fundamental role on the implant biocompatibility. In this thesis, nitrogen and argon plasma treatment was applied on chitosan membranes in order to improve their surface properties. The applied modifications promoted differences on surface chemistry, wettability and roughness, which reflected in a significant improvement of fibroblast adhesion and proliferation onto chitosan membranes. Besides the surface modification, blending of chitosan with proteins such as soy protein isolate and silk fibroin was also used to modify the bulk properties of chitosan. In situ cross-linking with glutaraldehyde solutions was

  9. Estimating community health needs against a Triple Aim background: What can we learn from current predictive risk models?

    Science.gov (United States)

    Elissen, Arianne M J; Struijs, Jeroen N; Baan, Caroline A; Ruwaard, Dirk

    2015-05-01

    To support providers and commissioners in accurately assessing their local populations' health needs, this study produces an overview of Dutch predictive risk models for health care, focusing specifically on the type, combination and relevance of included determinants for achieving the Triple Aim (improved health, better care experience, and lower costs). We conducted a mixed-methods study combining document analyses, interviews and a Delphi study. Predictive risk models were identified based on a web search and expert input. Participating in the study were Dutch experts in predictive risk modelling (interviews; n=11) and experts in healthcare delivery, insurance and/or funding methodology (Delphi panel; n=15). Ten predictive risk models were analysed, comprising 17 unique determinants. Twelve were considered relevant by experts for estimating community health needs. Although some compositional similarities were identified between models, the combination and operationalisation of determinants varied considerably. Existing predictive risk models provide a good starting point, but optimally balancing resources and targeting interventions on the community level will likely require a more holistic approach to health needs assessment. Development of additional determinants, such as measures of people's lifestyle and social network, may require policies pushing the integration of routine data from different (healthcare) sources. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  10. The influence of substrate source on the growth of Ralstonia eutropha, aiming at the production of polyhydroxyalkanoate

    Directory of Open Access Journals (Sweden)

    Marangoni C.

    2001-01-01

    Full Text Available With the aim of producing polyhydroxyalkanoates, a study of the influence of culture conditions (nitrogen and carbon sources and temperature on the growth of Ralstonia eutropha in stirred flasks was carried out and the use of some low-cost sources (hydrolyzed lactose, inverted sugar and corn steep liquor as evaluated. The best specific growth rate was obtained when inverted sugar was utilized as the substrate (mumax = 0.26 h-1. Two different phases in the assimilation of the carbon source were observed when hydrolyzed lactose was present, suggesting the assimilation first of glucose and then of galactose. To confirm the growth of Ralstonia eutropha using galactose as the only carbon source, experiments were carried out and the results showed that this bacterium is able to grow in the presence of this sugar at a growth rate of 0.13 h-1. The use of galactose by Ralstonia eutropha for its growth has not been reported in the literature until now. Corn steep liquor was found to be a viable alternative nitrogen source to ammonium sulfate. The results of experiments carried out at 30°C and 34°C were similar.

  11. Target-aimed versus wishful-thinking in designing efficient GHG reduction strategies for a metropolitan city: Taipei

    International Nuclear Information System (INIS)

    Liu, C.-M.; Liou, M.-L.; Yeh, S.-C.; Shang, N.-C.

    2009-01-01

    In recent years, many national and local governments claim for a specific GHG (greenhouse gas) reduction goal targeted for many years later. In 2005, the Taipei City government announced that Taipei's total GHG emission in 2015 will reach the same level as that in 2005 and then down to 75% of that level at year 2030. However, based on the estimated energy consumption and GHG emission and the proposed emission reduction plans from the local government, it is clear that these goals are not going to be accomplished. In Taipei, the residential and commercial sector contributes more than 78% of the total GHG emission. Thus, in a business as usual scenario, the total GHG emission in 2030 would be 79% more than that in 2005, far more than the target value proclaimed. As many key factors are uncontrollable by the local government, a target-aimed strategy designing process by looking into changes in Taipei and identifying major targets is proposed in this study. It is demonstrated that such a universally applicable approach will give more confidence to the public on working toward the expected GHG reduction goal

  12. Particle Swarm Optimization applied to combinatorial problem aiming the fuel recharge problem solution in a nuclear reactor

    International Nuclear Information System (INIS)

    Meneses, Anderson Alvarenga de Moura; Schirru, Roberto

    2005-01-01

    This work focuses on the usage the Artificial Intelligence technique Particle Swarm Optimization (PSO) to optimize the fuel recharge at a nuclear reactor. This is a combinatorial problem, in which the search of the best feasible solution is done by minimizing a specific objective function. However, in this first moment it is possible to compare the fuel recharge problem with the Traveling Salesman Problem (TSP), since both of them are combinatorial, with one advantage: the evaluation of the TSP objective function is much more simple. Thus, the proposed methods have been applied to two TSPs: Oliver 30 and Rykel 48. In 1995, KENNEDY and EBERHART presented the PSO technique to optimize non-linear continued functions. Recently some PSO models for discrete search spaces have been developed for combinatorial optimization. Although all of them having different formulation from the ones presented here. In this paper, we use the PSO theory associated with to the Random Keys (RK)model, used in some optimizations with Genetic Algorithms. The Particle Swarm Optimization with Random Keys (PSORK) results from this association, which combines PSO and RK. The adaptations and changings in the PSO aim to allow the usage of the PSO at the nuclear fuel recharge. This work shows the PSORK being applied to the proposed combinatorial problem and the obtained results. (author)

  13. Evaluating public education messages aimed at monitoring and responding to social interactive technology on smartphones among young drivers.

    Science.gov (United States)

    Gauld, Cassandra S; Lewis, Ioni; White, Katherine M; Fleiter, Judy J; Watson, Barry

    2017-07-01

    Young drivers are more likely than any other age group to access social interactive technology (e.g., Facebook, E-mail) on a smartphone while driving. The current study formed part of a larger investigation and was guided by The Step Approach to Message Design and Testing (SatMDT) to evaluate the relative effectiveness of three different public education messages aimed at reducing smartphone use among young drivers. The messages were each adapted to the specific behaviours of monitoring/reading and responding to social interactive technology on smartphones. Participants (n=288; 199F, 89M) were drivers aged 17-25 years who resided in the Australian state of Queensland. Message acceptance (i.e., intention and effectiveness) and message rejection were both assessed using a self-report survey. Multivariate analyses found that, overall, the messages targeting monitoring/reading behaviour were considered more effective than those targeting responding behaviour. The message that challenged the underlying motivation that believing you are a good driver makes it easier to monitor/read social interactive technology while driving was considered particularly effective by young male drivers. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. CONTROLAB: integration of intelligent systems for speech recognition, image processing, and trajectory control with obstacle avoidance aiming at robotics applications

    Science.gov (United States)

    Aude, Eliana P. L.; Silveira, Julio T. C.; Silva, Fabricio A. B.; Martins, Mario F.; Serdeira, Henrique; Lopes, Emerson P.

    1997-12-01

    CONTROLAB is an environment which integrates intelligent systems and control algorithms aiming at applications in the area of robotics. Within CONTROLAB, two neural network architectures based on the backpropagation and the recursive models are proposed for the implementation of a robust speaker-independent word recognition system. The robustness of the system using the backpropagation network has been largely verified through use by children and adults in totally uncontrolled environments such as large public halls for the exhibition of new technology products. Experimental results with the recursive network show that it is able to overcome the backpropagation network major drawback, the frequent generation of false alarms. In addition, within CONTROLAB, the trajectory to be followed by a robot arm under self-tuning control is determined by a system which uses either VGRAPH or PFIELD algorithms to avoid obstacles detected by the computer vision system. The performance of the second algorithm is greatly improved when it is applied under the control of a rule-based system. An application in which a SCARA robot arm is commanded by voice to pick up a specific tool placed on a table among other tools and obstacles is currently running. This application is used to evaluate the performance of each sub-system within CONTROLAB.

  15. 17 CFR 210.3A-01 - Application of § 210.3A-01 to § 210.3A-05.

    Science.gov (United States)

    2010-04-01

    ... Financial Statements § 210.3A-01 Application of § 210.3A-01 to § 210.3A-05. Sections 210.3A-01 to 210.3A-05 shall govern the presentation of consolidated and combined financial statements. [44 FR 19386, Apr. 3... COMMISSION FORM AND CONTENT OF AND REQUIREMENTS FOR FINANCIAL STATEMENTS, SECURITIES ACT OF 1933, SECURITIES...

  16. Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients.

    Science.gov (United States)

    Dihlmann, Susanne; Tao, Sha; Echterdiek, Fabian; Herpel, Esther; Jansen, Lina; Chang-Claude, Jenny; Brenner, Hermann; Hoffmeister, Michael; Kloor, Matthias

    2014-11-15

    Functional studies on colorectal cancer cells indicated a protective role of the interferon-inducible dsDNA sensor Absent in Melanoma 2 (AIM2) in cancer progression. Given that a high mutation rate and lack of AIM2 expression was previously detected in a subset of colorectal cancers, we here investigated the association of AIM2 expression in tumor cells and patient prognosis (5-year follow-up). A tissue microarray analysis of 476 matched tissue pairs (colorectal tumor and adjacent normal colon epithelium) was performed by two independent observers. Samples from 62 patients were excluded because of missing follow-up information or due to neo-adjuvant therapy before tissue sampling. Out of the remaining 414 tissue pairs, 279 (67.4%) displayed reduced AIM2 expression in cancer cells when compared to epithelial cells of their normal counterpart. Thirty-eight patients (9.18%) had completely lost AIM2 expression in tumor cells. After adjustment for sex, age, cancer stage, tumor site, tumor grade and chemotherapy, complete lack of AIM2 expression was associated with an up to 3-fold increase in overall mortality (HR=2.40; 95% CI=1.44-3.99) and disease specific mortality (HR=3.14; 95% CI=1.75-5.65) in comparison to AIM2-positive tumor samples. Our results demonstrate that lack of AIM2 expression is closely associated with poor outcome in colorectal cancer. The data thus strongly substantiate a protective role of AIM2 against progression of colorectal tumors. Further studies are required to assess whether lack of AIM2 expression may be used as a biomarker for the identification of colorectal cancer patients with poor prognosis. © 2014 UICC.

  17. The implementation of musculoskeletal injury-prevention exercise programmes in team ball sports: a systematic review employing the RE-AIM framework.

    Science.gov (United States)

    O'Brien, James; Finch, Caroline F

    2014-09-01

    Team ball sports such as soccer, basketball and volleyball have high participation levels worldwide. Musculoskeletal injuries are common in team ball sports and are associated with significant treatment costs, participation loss and long-term negative side effects. The results of recent randomized controlled trials provide support for the protective effect of injury-prevention exercise programmes (IPEPs) in team ball sports, but also highlight that achieving adequate compliance can be challenging. A key process in enhancing the ultimate impact of team ball sport IPEPs is identifying the specific implementation components that influence the adoption, execution and maintenance of these interventions. Despite this, no systematic review focussing on the specific implementation components of team ball sport IPEPs has been conducted. Our objective was to assess the reporting of specific implementation components in the published literature on team ball sport IPEPs using the Reach Efficacy Adoption Implementation Maintenance (RE-AIM) framework. Six electronic databases were systematically searched from inception to December 2012 for papers reporting team ball sport IPEP trials. All eligible papers were independently evaluated by two raters before reaching consensus on the reporting of individual RE-AIM items, using the RE-AIM Model Dimension Items Checklist (RE-AIM MDIC). A total of 60 papers, reporting 52 unique intervention trials, met eligibility criteria. Before consensus, the level of agreement across all trials between reviewers using the RE-AIM MDIC ranged from 81 to 91%. The RE-AIM MDIC dimension of 'efficacy' had the highest level of reporting, with the five individual items in this dimension reported in 19-100% of eligible trials (mean 58%). The RE-AIM MDIC dimension 'maintenance-setting level' had the lowest level of reporting, with none of the four individual items in this dimension reported. For other dimensions, the mean level of reporting and range across

  18. Urine specific gravity test

    Science.gov (United States)

    ... medlineplus.gov/ency/article/003587.htm Urine specific gravity test To use the sharing features on this page, please enable JavaScript. Urine specific gravity is a laboratory test that shows the concentration ...

  19. Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway

    Directory of Open Access Journals (Sweden)

    Celine C. Steinmetz

    2016-09-01

    Full Text Available Synaptic scaling is a form of homeostatic plasticity driven by transcription-dependent changes in AMPA-type glutamate receptor (AMPAR trafficking. To uncover the pathways involved, we performed a cell-type-specific screen for transcripts persistently altered during scaling, which identified the μ subunit (μ3A of the adaptor protein complex AP-3A. Synaptic scaling increased μ3A (but not other AP-3 subunits in pyramidal neurons and redistributed dendritic μ3A and AMPAR to recycling endosomes (REs. Knockdown of μ3A prevented synaptic scaling and this redistribution, while overexpression (OE of full-length μ3A or a truncated μ3A that cannot interact with the AP-3A complex was sufficient to drive AMPAR to REs. Finally, OE of μ3A acted synergistically with GRIP1 to recruit AMPAR to the dendritic membrane. These data suggest that excess μ3A acts independently of the AP-3A complex to reroute AMPAR to RE, generating a reservoir of receptors essential for the regulated recruitment to the synaptic membrane during scaling up.

  20. Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model.

    Science.gov (United States)

    Silva-Santos, Sara; van Woerden, Geeske M; Bruinsma, Caroline F; Mientjes, Edwin; Jolfaei, Mehrnoush Aghadavoud; Distel, Ben; Kushner, Steven A; Elgersma, Ype

    2015-05-01

    Angelman syndrome (AS) is a severe neurodevelopmental disorder that results from loss of function of the maternal ubiquitin protein ligase E3A (UBE3A) allele. Due to neuron-specific imprinting, the paternal UBE3A copy is silenced. Previous studies in murine models have demonstrated that strategies to activate the paternal Ube3a allele are feasible; however, a recent study showed that pharmacological Ube3a gene reactivation in adulthood failed to rescue the majority of neurocognitive phenotypes in a murine AS model. Here, we performed a systematic study to investigate the possibility that neurocognitive rescue can be achieved by reinstating Ube3a during earlier neurodevelopmental windows. We developed an AS model that allows for temporally controlled Cre-dependent induction of the maternal Ube3a allele and determined that there are distinct neurodevelopmental windows during which Ube3a restoration can rescue AS-relevant phenotypes. Motor deficits were rescued by Ube3a reinstatement in adolescent mice, whereas anxiety, repetitive behavior, and epilepsy were only rescued when Ube3a was reinstated during early development. In contrast, hippocampal synaptic plasticity could be restored at any age. Together, these findings suggest that Ube3a reinstatement early in development may be necessary to prevent or rescue most AS-associated phenotypes and should be considered in future clinical trial design.

  1. A Survey Aimed at General Citizens of the US and Japan about Their Attitudes toward Electronic Medical Data Handling

    Directory of Open Access Journals (Sweden)

    Michio Kimura

    2014-04-01

    Full Text Available Objectives: To clarify the views of the general population of two countries (US and Japan, concerning the handling of their medical records electronically. Methods: We contacted people nationwide in the United States at random via Random Digit Dialing (RDD to obtain 200 eligible responders. The questionnaire was for obtaining the information on their attitudes towards handling of their medical records, disclosure of the name of disease, secondary usage of information, compiling their records into a lifelong medical record, and access to their medical records on the Internet. We had also surveyed people of Shizuoka prefecture in Japan using same questionnaires sent by mail, for which we obtained 457 valid answers. Results: Even in an unidentifiable manner, US people feel profit-oriented usage of medical data without specific consent is not acceptable. There is a significant difference between usage of unidentifiable medical data for profit (about 50% feel negatively and for official/research purposes (about 30% feel negatively. About 60% of the US responders have a negative view on the proposal that unidentifiable medical information be utilized for profit by private companies to attain healthcare cost savings. As regards compiling a lifelong medical record, positive answers and negative answers are almost equally divided in the US (46% vs. 38% while more positive attitudes are seen in Japan (74% vs. 12%. However, any incentive measures aimed at changing attitudes to such a compiling including the discount of healthcare costs or insurance fees are unwelcomed by people regardless of their age or health condition in both surveys. Regarding the access to their own medical record via the Internet, 38% of the US responders feel this is unacceptable while 50.5% were willing to accept it. Conclusions: Participants from the US think that the extent of the sharing their identifiable medical records should be limited to the doctors-in-charge and specified

  2. Prevention of suicide with regulations aimed at restricting access to highly hazardous pesticides: a systematic review of the international evidence.

    Science.gov (United States)

    Gunnell, David; Knipe, Duleeka; Chang, Shu-Sen; Pearson, Melissa; Konradsen, Flemming; Lee, Won Jin; Eddleston, Michael

    2017-10-01

    Pesticide self-poisoning accounts for 14-20% of suicides worldwide. Regulation aimed at restricting access to pesticides or banning highly hazardous pesticides is one approach to reducing these deaths. We systematically reviewed the evidence of the effectiveness of pesticide regulation in reducing the incidence of pesticide suicides and overall suicides. We did a systematic review of the international evidence. We searched MEDLINE, PsycINFO, and Embase for studies published between Jan 1, 1960, and Dec 31, 2016, which investigated the effect of national or regional bans, and sales or import restrictions, on the availability of one or more pesticides and the incidence of suicide in different countries. We excluded other interventions aimed at limiting community access to pesticides. We extracted data from studies presenting pesticide suicide data and overall suicide data from before and after national sales restrictions. Two reviewers independently assessed papers for inclusion, extracted data, and assessed risk of bias. We undertook a narrative synthesis of the data in each report, and where data were available for the years before and after a ban, we pooled data for the 3 years before and the 3 years after to obtain a crude estimate of the effect of the ban. This study is registered through PROSPERO, number CRD42017053329. We identified 27 studies undertaken in 16 countries-five low-income or middle-income countries (Bangladesh, Colombia, India, Jordan and Sri Lanka), and 11 high-income countries (Denmark, Finland, Germany, Greece, Hungary, Ireland, Japan, South Korea, Taiwan, UK, and USA). Assessments largely focused on national bans of specific pesticides (12 studies of bans in six countries-Jordan, Sri Lanka, Bangladesh, Greece [Crete], South Korea, and Taiwan) or sales restrictions (eight studies of restrictions in five countries- India, Denmark, Ireland, the UK and the USA). Only five studies used optimum analytical methods. National bans on commonly ingested

  3. "Universe" event at AIMS

    Science.gov (United States)

    2008-06-01

    Report of event of 11 May 2008 held at the African Institute of Mathematical Sciences (Muizenberg, Cape), with speakers Michael Griffin (Administrator of NASA), Stephen Hawking (Cambridge), David Gross (Kavli Institute, Santa Barbara) and George Smoot (Berkeley).

  4. Aiming for the Green

    Science.gov (United States)

    Kennedy, Mike

    2007-01-01

    Times change, and pollution continues to plague cities, energy prices escalate and average temperatures creep higher, the argument that society cannot afford to squander its limited resources has been embraced by more than just environmental activists. More and more education administrators and architects are among those pushing schools and…

  5. Extravagant Aims, Distorted Practice

    Science.gov (United States)

    Porter, James

    2009-01-01

    In the decades after the Second World War, the British Government had a democratic, independent and locally administered education service that was recognised as crucial to the post-war political, moral and economic recovery of the country. However, since that time, the independence of schools and local communities has been increasingly usurped,…

  6. Study of high-definition and stereoscopic head-aimed vision for improved teleoperation of an unmanned ground vehicle

    Science.gov (United States)

    Tyczka, Dale R.; Wright, Robert; Janiszewski, Brian; Chatten, Martha Jane; Bowen, Thomas A.; Skibba, Brian

    2012-06-01

    Nearly all explosive ordnance disposal robots in use today employ monoscopic standard-definition video cameras to relay live imagery from the robot to the operator. With this approach, operators must rely on shadows and other monoscopic depth cues in order to judge distances and object depths. Alternatively, they can contact an object with the robot's manipulator to determine its position, but that approach carries with it the risk of detonation from unintentionally disturbing the target or nearby objects. We recently completed a study in which high-definition (HD) and stereoscopic video cameras were used in addition to conventional standard-definition (SD) cameras in order to determine if higher resolutions and/or stereoscopic depth cues improve operators' overall performance of various unmanned ground vehicle (UGV) tasks. We also studied the effect that the different vision modes had on operator comfort. A total of six different head-aimed vision modes were used including normal-separation HD stereo, SD stereo, "micro" (reduced separation) SD stereo, HD mono, and SD mono (two types). In general, the study results support the expectation that higher resolution and stereoscopic vision aid UGV teleoperation, but the degree of improvement was found to depend on the specific task being performed; certain tasks derived notably more benefit from improved depth perception than others. This effort was sponsored by the Joint Ground Robotics Enterprise under Robotics Technology Consortium Agreement #69-200902 T01. Technical management was provided by the U.S. Air Force Research Laboratory's Robotics Research and Development Group at Tyndall AFB, Florida.

  7. Netherlands Public Private Partnerships Aimed at Co-Innovation in the Potato Value Chain in Emerging Markets

    Directory of Open Access Journals (Sweden)

    Kempenaar C.

    2017-11-01

    Full Text Available Since 2013 the Netherlands Ministries of Economic and Foreign Affairs has been involved in private companies in research and development (R&D in developing countries. This in a policy going “from aid to trade”. Especially in upcoming markets, R&D is carried out through Public Private Partnerships. Such partnerships not only include R&D organizations in the two countries but specifically also include businesses in both countries. This was to assure a logical flow of material and knowledge by all parties involved. Half of an R&D project is funded by the ministry and the rest is covered by a consortium of companies that contribute in kind and in cash. The policy is aimed at stimulating business development in developing countries and the Netherlands through cooperation and joint R&D. The paper explains how eleven consortia around potato business opportunities were formed, their R&D need was elicited and R&D projects formulated in the Asian countries China, India, Indonesia, Vietnam, Bangladesh and Myanmar, and Ethiopia and Kenya in Africa. In common are fact finding and descriptions of cropping systems, yield gap analysis and value chains in each country. Emphases differ with China looking for an integrated system of field operations, India for optimization of storage and processing, Indonesia to reduce pesticide and nutrient inputs, Vietnam for widening the varietal base, Bangladesh for combating late blight, Myanmar for cultural practices that lead to increased yield, Ethiopia where a potato processing unit is being established and Kenya importing seed potato from the Netherlands. Some content information is given as examples to illustrate the approach and some preliminary conclusion are discussed.

  8. Porcine foetal and neonatal CYP3A liver expression

    DEFF Research Database (Denmark)

    Hermann-Bank, Marie Louise; Skaanild, Mette Tingleff

    2011-01-01

    Human cytochrome P450 3A7 (CYP3A7) and cytochrome P450 3A4 (CYP3A4) are hepatic metabolising enzymes which participates in the biotransformation of endo- and exogenous substances in foetuses and neonates respectively. These CYP3A enzymes display an inverse relationship: CYP3A7 is the dominant...... microsomes using western blotting. The expression of CYP3A29 was approximately 9- fold greater in neonates compared to foetuses, and a similar difference was reflected on the immunochemical level. It was not possible to detect a significant level of foetal CYP3A7 mRNA, but immunoblotting showed a visible...

  9. A method of teaching critical care skills to undergraduate student midwives using the Maternal-Acute Illness Management (M-AIM) training day.

    Science.gov (United States)

    McCarthy, Rose; Nuttall, Janet; Smith, Joyce; Hollins Martin, Caroline J

    2014-11-01

    The most recent Confidential Enquiry into Maternal Deaths (CMACE, 2011) identified human errors, specifically those of midwives and obstetricians/doctors as a fundamental component in contributing to maternal death in the U.K. This paper discusses these findings and outlines a project to provide training in Maternal-Acute Illness Management (M-AIM) to final year student midwives. Contents of the program are designed to educate and simulate AIM skills and increase confidence and clinical ability in early recognition, management and referral of the acutely ill woman. An outline of the Maternal-AIM program delivered at the University of Salford (Greater Manchester, UK) is presented to illustrate how this particular institution has responded to a perceived need voiced by local midwifery leaders. It is proposed that developing this area of expertise in the education system will better prepare student midwives for contemporary midwifery practice. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  10. AIM2 Co-immunization with VP1 Is Associated with Increased Memory CD8 T Cells and Mounts Long Lasting Protection against Coxsackievirus B3 Challenge.

    Science.gov (United States)

    Yin, Liang; Chai, Dafei; Yue, Yan; Dong, Chunsheng; Xiong, Sidong

    2017-01-01

    The recurrent Coxsackievirus B3 (CVB3) infection is the most important cause of intractable myocarditis which often leads to chronic myocarditis and even dilated cardiomyopathy. Therefore, enhanced DNA vaccines capable of memory CD8 T cells are essential for long-lasting immunological protection against CVB3 infection. In this study, absent in melanoma 2 (AIM2) was used as an adjuvant to enhance the induction of memory CD8 T cells elicited by VP1 (viral capsid protein 1) vaccine. Mice were intramuscularly injected with 50 μg AIM2 plasmid and equal amount of VP1 plasmid (pAIM2/pVP1) vaccine 4 times at 2 week-intervals. We observed that the protection of pAIM2/pVP1 vaccine against CVB3 challenge was evidenced by significantly improved cardiac function, reduced myocardial injuries, and increased survival rate when compared with immunization with pVP1. Co-immunization with pAIM2/pVP1 robustly augmented T lymphocytes proliferation and CVB3-specific cytotoxic T lymphocyte responses. Importantly, 16 weeks after the last immunization, pAIM2/pVP1 co-immunization significantly enhanced the expression of Bcl-6, SOCS3, and Sca-1 which are critical for memory CD8 T cells as compared with pVP1 immunization. Notably, CD8 T cells that are likely vaccine-induced memory T cells were responsible for the protective efficacy of pAIM2/pVP1 vaccine by abolition of a CD8 T cell immune response following a lethal dose of CVB3 infection. Our results indicate that AIM2-adjuvanted vaccine could be a potential and promising approach to promote a long-lasting protection against CVB3-induced myocarditis.

  11. AIM2 Co-immunization with VP1 Is Associated with Increased Memory CD8 T Cells and Mounts Long Lasting Protection against Coxsackievirus B3 Challenge

    Directory of Open Access Journals (Sweden)

    Liang Yin

    2017-06-01

    Full Text Available The recurrent Coxsackievirus B3 (CVB3 infection is the most important cause of intractable myocarditis which often leads to chronic myocarditis and even dilated cardiomyopathy. Therefore, enhanced DNA vaccines capable of memory CD8 T cells are essential for long-lasting immunological protection against CVB3 infection. In this study, absent in melanoma 2 (AIM2 was used as an adjuvant to enhance the induction of memory CD8 T cells elicited by VP1 (viral capsid protein 1 vaccine. Mice were intramuscularly injected with 50 μg AIM2 plasmid and equal amount of VP1 plasmid (pAIM2/pVP1 vaccine 4 times at 2 week-intervals. We observed that the protection of pAIM2/pVP1 vaccine against CVB3 challenge was evidenced by significantly improved cardiac function, reduced myocardial injuries, and increased survival rate when compared with immunization with pVP1. Co-immunization with pAIM2/pVP1 robustly augmented T lymphocytes proliferation and CVB3-specific cytotoxic T lymphocyte responses. Importantly, 16 weeks after the last immunization, pAIM2/pVP1 co-immunization significantly enhanced the expression of Bcl-6, SOCS3, and Sca-1 which are critical for memory CD8 T cells as compared with pVP1 immunization. Notably, CD8 T cells that are likely vaccine-induced memory T cells were responsible for the protective efficacy of pAIM2/pVP1 vaccine by abolition of a CD8 T cell immune response following a lethal dose of CVB3 infection. Our results indicate that AIM2-adjuvanted vaccine could be a potential and promising approach to promote a long-lasting protection against CVB3-induced myocarditis.

  12. Predicting the "First dose in children" of CYP3A-metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages.

    Science.gov (United States)

    Strougo, Ashley; Yassen, Ashraf; Monnereau, Claire; Danhof, Meindert; Freijer, Jan

    2014-09-01

    First-dose-in-children relies on the prediction of clearance from adults for which little information is available on the accuracy of the scaling-approaches applied. For CYP3A-metabolized compounds, scaling of clearance is further challenged by different isoforms and by the CYP3A7 to CYP3A4 switch at young ages. This investigation aimed to evaluate the accuracy of two frequently used scaling approaches and to gain insights into the ontogeny of CYP3A. Hence, a literature database was compiled containing 203 clearance values from term-neonates to adults for 18 CYP3A-metabolized compounds. The clearances in adults were scaled to children using (i) allometric scaling plus maturation function and (ii) a mechanistic approach based on the well-stirred model. Three maturation functions were separately evaluated. In children >3 months, all approaches were interchangeable heeding the maturation function applied and biases were mostly observed in children ages. The current investigation adds to the predictions of the first-dose-in-children of compounds (partially) metabolized by CYP3A. © 2014, The American College of Clinical Pharmacology.

  13. FOXP3-specific immunity

    OpenAIRE

    Andersen, Mads Hald

    2013-01-01

    Forkhead box P3 (FOXP3)-specific cytotoxic CD8+ T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3 and regulatory T cells, but also to kill FOXP3+ malignant T cells. The natural occurrence of FOXP3-specific cytotoxic T lymphocytes among human PBMCs suggests a general role for these cells in the complex network ...

  14. Graphical And Textual Notations In Formal Specification

    Energy Technology Data Exchange (ETDEWEB)

    Bove, Rocco; Dipoppa, Giovanni; Groven, Arne-Kristian; Sivertsen, Terje

    1996-07-01

    The present report describes the current status of the co-operative project between ENEA and the OECD Halden Reactor Project on graphical and formal methods for software specification. The aim of this project is to contribute to a clarification of the relationship between graphical descriptions and formal specifications, and to provide guidelines for how they can be combined in order to utilize the strengths of' each approach. The overall aim of such a combination is to improve the formal basis of graphical descriptions and make formal specifications more generally comprehensible. The research reported includes the application of the IPTES technology on the APRM case example, an approach to the translation of Petri nets into algebraic specification, and the specification of real-time distributed systems using time-extended LOTOS. (author)

  15. [Specificities in children wound healing].

    Science.gov (United States)

    Sanchez, J; Antonicelli, F; Tuton, D; Mazouz Dorval, S; François, C

    2016-10-01

    Children have specific characteristics of wound healing. The aim of this study was to describe the specific clinical characteristics of wounds healing in children and to present the current knowledge on the specific mechanisms with regard to infant age. The tissue insult or injury in fetus can heal without scar, mainly due to reduced granulation tissue associated to diminished or even no inflammatory phase, modified extracellular matrix such as the concentration of hyaluronic acid in amniotic liquid, expression and arrangement of collagen and tenascin. Thickness of children skin is a serious negative factor in case of trauma, whereas poor co-morbidities and efficient growth tissue mechanisms are beneficial to good evolution, even in cases of extensive damage and loss of tissue. The subsequent tissue mechanical forces, wound healing during childhood, spanning from the age of 2 until the end of puberty, is associated with more hypertrophic scars, both in duration and in intensity. Consequently, unnecessary surgery has to be avoided during this period when possible, and children with abnormal or pathologic wound healing should benefit from complementary treatments (hydration, massage, brace, silicone, hydrotherapy…), which represent efficient factors to minimize tissue scarring. After wound healing, the growth body rate can be responsible for specific complications, such as contractures, alopecia, and scar intussusceptions. Its evolutionary character implies the need of an attentive follow-up until adult age. Psychologic repercussions, as a consequence of pathologic scars, must be prevented and investigated by the surgeon. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  16. Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses

    DEFF Research Database (Denmark)

    Gottwein, Judith M; Jensen, Sanne B; Li, Yi-Ping

    2013-01-01

    -FL) recombinants relying only on the JFH1 NS3 helicase, NS5B, and the 3' untranslated region. With identified adaptive mutations, semi-FL recombinants of genotypes(isolates) 1a(TN) and 3a(S52) produced supernatant infectivity titers of ~4 log(10) focus-forming units/ml in Huh7.5 cells. Genotype 1a(TN) adaptive......With the development of directly acting antivirals, hepatitis C virus (HCV) therapy entered a new era. However, rapid selection of resistance mutations necessitates combination therapy. To study combination therapy in infectious culture systems, we aimed at developing HCV semi-full-length (semi....... Inhibitors showed synergism at drug concentrations reported in vivo. In summary, semi-FL HCV recombinants, including the most advanced reported genotype 3a infectious culture system, permitted genotype-specific analysis of combination treatment in the context of the complete viral life cycle. Despite...

  17. Review of technical specifications

    International Nuclear Information System (INIS)

    Bedrich, M.; Scholz, D.

    1980-01-01

    The present paper deals with position and function of technical specifications before and during the manufacturing of reactor components, their structure and reasons for specific regulations due to safety philosophy and explains the cooperation of supplier, manufacturer, utilities and supervisory organizations. (RW)

  18. Place-Specific Computing

    DEFF Research Database (Denmark)

    Messeter, Jörn

    2009-01-01

    An increased interest in the notion of place has evolved in interaction design based on the proliferation of wireless infrastructures, developments in digital media, and a ‘spatial turn’ in computing. In this article, place-specific computing is suggested as a genre of interaction design...... that addresses the shaping of interactions among people, place-specific resources and global socio-technical networks, mediated by digital technology, and influenced by the structuring conditions of place. The theoretical grounding for place-specific computing is located in the meeting between conceptions...... examples of place-specific computing are presented from a series of pilot studies, conducted in close collaboration with design students in Malmö, Berlin, Cape Town and Rome, that generated 36 design concepts in the genre. Reflecting on these examples, issues in the design of place-specific computing...

  19. Status and prospect of R and D aimed at application of nuclear reactors for seawater desalination in Russia

    Energy Technology Data Exchange (ETDEWEB)

    Zverev, K.V. [MINATOM, Moscow (Russian Federation); Baranaev, Y.D. [Thermal Reactors, SSC RF - IPPE, Obninsk, Kaluga Region (Russian Federation)]. E-mail: baranaev@ippe.obninsk.ru; Toshinsky, G.I. [Thermal Reactors, SSC RF - IPPE, Obninsk, Kaluga Region (Russian Federation); Polunichev, V.I. [OKBM, Nizhny Novgorod (Russian Federation); Romenkov, A.A. [RDIPE, Moscow (Russian Federation)]. E-mail: romenkov@entek.ru; Shamanin, V.G. [JSC Malaya Energetica, Moscow (Russian Federation); Podberezny, V.L. [JSC NPP Mashprom, Ekatrinbourg (Russian Federation)

    2004-07-01

    Desalination Projects and Case Studies'. Participation of Russian organisations based first of all on possibility to evaluate technical and economic feasibility, expediency and efficiency of use of the Russian nuclear desalination complexes on specific sites in cooperation with the potential customers. As an important aspect of activity in nuclear desalination the RF MINATOM considers the Russian-Canadian Project of a floating nuclear desalination complex based on Russian floating power unit and Canadian preheating RO desalination units. Last year, the Project advanced essentially in organisational and technical matters both in Russia and Canada. Russia possesses of a broad experience in development and construction of the conventional distillation desalination plants inside the country and abroad. Last year's progress in desalination technology has been made on horizontal tube MED unites DOU GTPA type. Application of these units designed in wide range of capacity is considered and evaluated in all studies on nuclear desalination. In general, the RF MINATOM is interested in cooperation aimed at a practical implementation of projects in the field of nuclear desalination. Both nuclear reactors and desalination units are available and offered to the partners as a starting point for joint development of a cooperation project. (author)

  20. New symbol launched to warn public about radiation dangers. Supplementary symbol aims to help reduce needless deaths and injuries

    International Nuclear Information System (INIS)

    2007-01-01

    Full text: With radiating waves, a skull and crossbones and a running person, a new ionizing radiation warning symbol is being introduced to supplement the traditional international symbol for radiation, the three cornered trefoil. The new symbol is being launched today by the IAEA and the International Organization for Standardization (ISO) to help reduce needless deaths and serious injuries from accidental exposure to large radioactive sources. It will serve as a supplementary warning to the trefoil, which has no intuitive meaning and little recognition beyond those educated in its significance. 'I believe the international recognition of the specific expertise of both organizations will ensure that the new standard will be accepted and applied by governments and industry to improve the safety of nuclear applications, protection of people and the environment', said Ms. Eliana Amaral, Director, Division of Radiation, Transport and Waste Safety, IAEA. The new symbol is aimed at alerting anyone, anywhere to the potential dangers of being close to a large source of ionizing radiation, the result of a five-year project conducted in 11 countries around the world. The symbol was tested with different population groups - mixed ages, varying educational backgrounds, male and female - to ensure that its message of 'danger- stay away' was crystal clear and understood by all. 'We can't teach the world about radiation,' said Carolyn Mac Kenzie, an IAEA radiation specialist who helped develop the symbol, 'but we can warn people about dangerous sources for the price of sticker.' The new symbol, developed by human factor experts, graphic artists, and radiation protection experts, was tested by the Gallup Institute on a total of 1 650 individuals in Brazil, Mexico, Morocco, Kenya, Saudi Arabia, China, India, Thailand, Poland, Ukraine and the United States. The symbol is intended for IAEA Category 1, 2 and 3 sources defined as dangerous sources capable of death or serious injury

  1. New symbol launched to warn public about radiation dangers. Supplementary symbol aims to help reduce needless deaths and injuries

    International Nuclear Information System (INIS)

    2007-01-01

    Full text: With radiating waves, a skull and crossbones and a running person, a new ionizing radiation warning symbol is being introduced to supplement the traditional international symbol for radiation, the three cornered trefoil. The new symbol is being launched today by the IAEA and the International Organization for Standardization (ISO) to help reduce needless deaths and serious injuries from accidental exposure to large radioactive sources. It will serve as a supplementary warning to the trefoil, which has no intuitive meaning and little recognition beyond those educated in its significance. 'I believe the international recognition of the specific expertise of both organizations will ensure that the new standard will be accepted and applied by governments and industry to improve the safety of nuclear applications, protection of people and the environment', said Ms. Eliana Amaral, Director, Division of Radiation, Transport and Waste Safety, IAEA. The new symbol is aimed at alerting anyone, anywhere to the potential dangers of being close to a large source of ionizing radiation, the result of a five-year project conducted in 11 countries around the world. The symbol was tested with different population groups - mixed ages, varying educational backgrounds, male and female - to ensure that its message of 'danger- stay away' was crystal clear and understood by all. 'We can't teach the world about radiation,' said Carolyn Mac Kenzie, an IAEA radiation specialist who helped develop the symbol, 'but we can warn people about dangerous sources for the price of sticker.' The new symbol, developed by human factor experts, graphic artists, and radiation protection experts, was tested by the Gallup Institute on a total of 1 650 individuals in Brazil, Mexico, Morocco, Kenya, Saudi Arabia, China, India, Thailand, Poland, Ukraine and the United States. The symbol is intended for IAEA Category 1, 2 and 3 sources defined as dangerous sources capable of death or serious injury

  2. New symbol launched to warn public about radiation dangers. Supplementary symbol aims to help reduce needless deaths and injuries

    International Nuclear Information System (INIS)

    2007-01-01

    Full text: With radiating waves, a skull and crossbones and a running person, a new ionizing radiation warning symbol is being introduced to supplement the traditional international symbol for radiation, the three cornered trefoil. The new symbol is being launched today by the IAEA and the International Organization for Standardization (ISO) to help reduce needless deaths and serious injuries from accidental exposure to large radioactive sources. It will serve as a supplementary warning to the trefoil, which has no intuitive meaning and little recognition beyond those educated in its significance. 'I believe the international recognition of the specific expertise of both organizations will ensure that the new standard will be accepted and applied by governments and industry to improve the safety of nuclear applications, protection of people and the environment', said Ms. Eliana Amaral, Director, Division of Radiation, Transport and Waste Safety, IAEA. The new symbol is aimed at alerting anyone, anywhere to the potential dangers of being close to a large source of ionizing radiation, the result of a five-year project conducted in 11 countries around the world. The symbol was tested with different population groups - mixed ages, varying educational backgrounds, male and female - to ensure that its message of 'danger- stay away' was crystal clear and understood by all. 'We can't teach the world about radiation,' said Carolyn Mac Kenzie, an IAEA radiation specialist who helped develop the symbol, 'but we can warn people about dangerous sources for the price of sticker.' The new symbol, developed by human factor experts, graphic artists, and radiation protection experts, was tested by the Gallup Institute on a total of 1 650 individuals in Brazil, Mexico, Morocco, Kenya, Saudi Arabia, China, India, Thailand, Poland, Ukraine and the United States. The symbol is intended for IAEA Category 1, 2 and 3 sources defined as dangerous sources capable of death or serious injury

  3. New symbol launched to warn public about radiation dangers. Supplementary symbol aims to help reduce needless deaths and injuries

    International Nuclear Information System (INIS)

    2007-01-01

    Full text: With radiating waves, a skull and crossbones and a running person, a new ionizing radiation warning symbol is being introduced to supplement the traditional international symbol for radiation, the three cornered trefoil. The new symbol is being launched today by the IAEA and the International Organization for Standardization (ISO) to help reduce needless deaths and serious injuries from accidental exposure to large radioactive sources. It will serve as a supplementary warning to the trefoil, which has no intuitive meaning and little recognition beyond those educated in its significance. 'I believe the international recognition of the specific expertise of both organizations will ensure that the new standard will be accepted and applied by governments and industry to improve the safety of nuclear applications, protection of people and the environment', said Ms. Eliana Amaral, Director, Division of Radiation, Transport and Waste Safety, IAEA. The new symbol is aimed at alerting anyone, anywhere to the potential dangers of being close to a large source of ionizing radiation, the result of a five-year project conducted in 11 countries around the world. The symbol was tested with different population groups - mixed ages, varying educational backgrounds, male and female - to ensure that its message of 'danger- stay away' was crystal clear and understood by all. 'We can't teach the world about radiation,' said Carolyn Mac Kenzie, an IAEA radiation specialist who helped develop the symbol, 'but we can warn people about dangerous sources for the price of sticker.' The new symbol, developed by human factor experts, graphic artists, and radiation protection experts, was tested by the Gallup Institute on a total of 1 650 individuals in Brazil, Mexico, Morocco, Kenya, Saudi Arabia, China, India, Thailand, Poland, Ukraine and the United States. The symbol is intended for IAEA Category 1, 2 and 3 sources defined as dangerous sources capable of death or serious injury

  4. Cheap-GSHPs, an European project aiming cost-reducing innovations for shallow geothermal installations. - Geological data reinterpretation

    Science.gov (United States)

    Bertermann, David; Müller, Johannes; Galgaro, Antonio; Cultrera, Matteo; Bernardi, Adriana; Di Sipio, Eloisa

    2016-04-01

    The success and widespread diffusion of new sustainable technologies are always strictly related to their affordability. Nowadays the energy price fluctuations and the economic crisis are jeopardizing the development and diffusion of renewable technologies and sources. With the aim of both reduce the overall costs of shallow geothermal systems and improve their installation safety, an European project has took place recently, under the Horizon 2020 EU Framework Programme for Research and Innovation. The acronym of this project is Cheap-GSHPs, meaning "cheap and efficient application of reliable ground source heat exchangers and pumps"; the CHEAP-GSHPs project involves 17 partners among 9 European countries such Belgium, France, Germany, Greece, Ireland, Italy, Romania, Spain, Switzerland. In order to achieve the planned targets, an holistic approach is adopted, where all involved elements that take part of shallow geothermal activities are here integrated. In order to reduce the drilling specific costs and for a solid planning basis the INSPIRE-conformal ESDAC data set PAR-MAT-DOM ("parent material dominant") was analysed and reinterpreted regarding the opportunities for cost reductions. Different ESDAC classification codes were analysed lithologically and sedimentologically in order to receive the most suitable drilling technique within different formations. Together with drilling companies this geological data set was translated into a geotechnical map which allows drilling companies the usage of the most efficient drilling within a certain type of underground. The scale of the created map is 1: 100,000 for all over Europe. This leads to cost reductions for the final consumers. Further there will be the definition of different heat conductivity classes based on the reinterpreted PAR-MAT-DOM data set which will provide underground information. These values will be reached by sampling data all over Europe and literature data. The samples will be measured by several

  5. Pulsed Accretion in the T Tauri Binary TWA 3A

    Energy Technology Data Exchange (ETDEWEB)

    Tofflemire, Benjamin M.; Mathieu, Robert D. [Department of Astronomy, University of Wisconsin–Madison, 475 North Charter Street, Madison, WI 53706 (United States); Herczeg, Gregory J. [The Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Akeson, Rachel L.; Ciardi, David R. [NASA Exoplanet Science Institute, IPAC/Caltech, Pasadena, CA 91125 (United States)

    2017-06-20

    TWA 3A is the most recent addition to a small group of young binary systems that both actively accrete from a circumbinary disk and have spectroscopic orbital solutions. As such, it provides a unique opportunity to test binary accretion theory in a well-constrained setting. To examine TWA 3A’s time-variable accretion behavior, we have conducted a two-year, optical photometric monitoring campaign, obtaining dense orbital phase coverage (∼20 observations per orbit) for ∼15 orbital periods. From U -band measurements we derive the time-dependent binary mass accretion rate, finding bursts of accretion near each periastron passage. On average, these enhanced accretion events evolve over orbital phases 0.85 to 1.05, reaching their peak at periastron. The specific accretion rate increases above the quiescent value by a factor of ∼4 on average but the peak can be as high as an order of magnitude in a given orbit. The phase dependence and amplitude of TWA 3A accretion is in good agreement with numerical simulations of binary accretion with similar orbital parameters. In these simulations, periastron accretion bursts are fueled by periodic streams of material from the circumbinary disk that are driven by the binary orbit. We find that TWA 3A’s average accretion behavior is remarkably similar to DQ Tau, another T Tauri binary with similar orbital parameters, but with significantly less variability from orbit to orbit. This is only the second clear case of orbital-phase-dependent accretion in a T Tauri binary.

  6. Effectiveness of an Interactive Website Aimed at Empowerment of Disability Benefit Claimants: Results of a Pragmatic Randomized Controlled Trial

    NARCIS (Netherlands)

    Samoocha, David; Snels, Ingrid A. K.; Bruinvels, David J.; Anema, Johannes R.; van der Beek, Allard J.

    2011-01-01

    Introduction The aim of this study was to investigate the effectiveness of an interactive website aimed at empowerment of disability claimants, prior to the assessment of disability by an insurance physician. Methods A randomized controlled trial was conducted. Claimants applying for a work

  7. Process evaluation of a multifaceted health program aiming to improve physical activity levels and dietary patterns among construction workers

    NARCIS (Netherlands)

    Viester, L.; Verhagen, E.A.L.M.; Bongers, P.M.; Beek, A.J. van der

    2014-01-01

    Objective: To evaluate the process of a health promotion program, aiming to improve physical activity levels and diet among construction workers. Methods: The process evaluation was conducted after the RE-AIM framework for the evaluation of the public health impact of health promotion interventions.

  8. To report or not to report: a psychosocial investigation aimed at improving early detection of avian influenza outbreaks

    NARCIS (Netherlands)

    Elbers, A.R.W.; Gorgievski, M.J.; Zarafshani, K.; Koch, G.

    2010-01-01

    The aim of this study was to identify limitations - and solutions for those limitations – with respect to reporting clinically suspect situations on poultry farms, possibly caused by Avian Influenza (AI) with the ultimate aim to facilitate early detection of AI-outbreaks. Focus group sessions were

  9. To report or not to report: a psychosocial investigation aimed at improving early detection of Avian Influenza outbreaks

    NARCIS (Netherlands)

    A.R.W. Elbers; M.J. Gorgievski-Duijvesteijn (Marjan); K. Zarafshani (Kiumars); G. Koch (Guus)

    2010-01-01

    textabstractSummary: The aim of this study was to identify difficulties and barriers to reporting clinically suspect situations, possibly caused by avian influenza (AI), and to explore possible incentives to reporting such situations, with the ultimate aim of facilitating early detection of AI

  10. Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells

    Directory of Open Access Journals (Sweden)

    Satoko Arai

    2013-04-01

    Full Text Available Natural immunoglobulin M (IgM is reactive to autoantigens and is believed to be important for autoimmunity. Blood pentameric IgM loaded with antigens forms a large immune complex (IC that contains various elements, including apoptosis inhibitor of macrophage (AIM. Here we demonstrate that this IgM-AIM association contributes to autoantibody production under obese conditions. In mice fed a high-fat diet, natural IgM increased through B cell TLR4 stimulation. AIM associated with IgM and protected AIM from renal excretion, increasing blood AIM levels along with the obesity-induced IgM augmentation. Meanwhile, the AIM association inhibited IgM binding to the Fcα/μ receptor on splenic follicular dendritic cells, thereby protecting the IgM IC from Fcα/μ receptor-mediated internalization. This supported IgM-dependent autoantigen presentation to B cells, stimulating IgG autoantibody production. Accordingly, in obese AIM-deficient (AIM−/− mice, the increase of multiple IgG autoantibodies observed in obese wild-type mice was abrogated. Thus, the AIM-IgM association plays a critical role in the obesity-associated autoimmune process.

  11. Money's (Not) On My Mind: A Qualitative Study Of How Staff And Managers Understand Health Care's Triple Aim

    DEFF Research Database (Denmark)

    Storkholm, Marie Højriis

    -structured interviews with managers and staff in a clinical department successful in achieving the Triple Aim. Results Participants identified themselves with the Triple Aim along classic professional divides. Four mental models that underlie these affinities suggest that while staff tended to see the Triple Aim......Money’s (not) on my mind: A qualitative study of how staff and managers understand health care’s Triple Aim Purpose The “Triple Aim” – provision of a better care experience and improved population health at a lower cost – seems theoretically sound but in practice it´s difficult to achieve....... This study aimed to explore staff and manager’s understandings and underlying mental models, which guide planning and change strategies to implement organizational interventions when facing efficiency requirements. Design/methodology We performed an inductive content analysis of thirty semi...

  12. FOXP3-specific immunity

    DEFF Research Database (Denmark)

    Andersen, Mads Hald

    2013-01-01

    Forkhead box P3 (FOXP3)-specific cytotoxic CD8(+) T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3...... and regulatory T cells, but also to kill FOXP3(+) malignant T cells. The natural occurrence of FOXP3-specific cytotoxic T lymphocytes among human PBMCs suggests a general role for these cells in the complex network of immune regulation....

  13. Increased Amplitude of the P3a ERP Component as a Neurocognitive Marker for Differentiating Amnestic Subtypes of Mild Cognitive Impairment

    Directory of Open Access Journals (Sweden)

    Kenia S. Correa-Jaraba

    2018-02-01

    Full Text Available The event-related potential (ERP technique has been shown to be useful for evaluating changes in brain electrical activity associated with different cognitive processes, particularly in Alzheimer’s disease (AD. Longitudinal studies have shown that a high proportion of people with amnestic mild cognitive impairment (aMCI go on to develop AD. aMCI is divided into two subtypes according to the presence of memory impairment only (single-domain aMCI: sdaMCI or impairment of memory and other cognitive domains (multi-domain aMCI: mdaMCI. The main aim of this study was to examine the effects of sdaMCI and mdaMCI on the P3a ERP component associated with the involuntary orientation of attention toward unattended infrequent novel auditory stimuli. Participants performed an auditory-visual distraction-attention task, in which they were asked to ignore the auditory stimuli (standard, deviant, and novel and to attend to the visual stimuli (responding to some of them: Go stimuli. P3a was identified in the Novel minus Standard difference waveforms, and reaction times (RTs and hits (in response to Go stimuli were also analyzed. Participants were classified into three groups: Control, 20 adults (mean age (M: 65.8 years; sdaMCI, 19 adults (M: 67 years; and mdaMCI, 11 adults (M: 71 years. In all groups, the RTs were significantly longer when Go stimuli were preceded by novel (relative to standard auditory stimuli, suggesting a distraction effect triggered by novel stimuli; mdaMCI participants made significantly fewer hits than control and sdaMCI participants. P3a comprised two consecutive phases in all groups: early-P3a (e-P3a, which may reflect the orienting response toward the irrelevant stimuli, and late-P3a (l-P3a, which may be a correlate of subsequent evaluation of these stimuli. The e-P3a amplitude was significantly larger in mdaMCI than in sdaMCI participants, and the l-P3a amplitude was significantly larger in mdaMCI than in sdaMCI and Control

  14. TWRSview system requirements specification

    International Nuclear Information System (INIS)

    Caldwell, J.A.; Lee, A.K.

    1995-12-01

    This document provides the system requirements specification for the TWRSview software system. The TWRSview software system is being developed to integrate electronic data supporting the development of the TWRS technical baseline

  15. Place-Specific Computing

    DEFF Research Database (Denmark)

    Messeter, Jörn; Johansson, Michael

    An increased interest in the notion of place has evolved in interaction design. Proliferation of wireless infrastructure, developments in digital media, and a ‘spatial turn’ in computing provides the base for place-specific computing as a suggested new genre of interaction design. In the REcult...... project place- specific computing is explored through design oriented research. This article reports six pilot studies where design students have designed concepts for place-specific computing in Berlin (Germany), Cape Town (South Africa), Rome (Italy) and Malmö (Sweden). Background and arguments...... for place-specific computing as a genre of interaction design are described. A total number of 36 design concepts designed for 16 designated zones in the four cities are presented. An analysis of the design concepts is presented indicating potentials, possibilities and problems as directions for future...

  16. Construction and material specification

    Science.gov (United States)

    2002-01-01

    These Construction and Material Specifications are written to the Bidder before award of the : Contract and to the Contractor after award of the Contract. The sentences that direct the Contractor to perform Work are written as commands. For example, ...

  17. Test Equipment Specifications Transistor

    OpenAIRE

    Didiek Andiana Ramadan; Drs. Linga Hermanto, MMSI Drs. Linga Hermanto, MMSI

    2005-01-01

    In this paper, we design a test apparatus Transistor Specification. Specification is atype of transistor is a transistor and common emitter current reinforcement value ( βDC ). The system will provide information in the form of an LED display emits greenlight when the tested types of NPN transistor and the second LED emits blue lightwhen the tested types of PNP transistors.To test the value of β, whose value is proportional to the display used by the collectorcurrent Ic.

  18. How Does Attention Relate to the Ability-Specific and Position-Specific Components of Reasoning Measured by APM?

    Science.gov (United States)

    Ren, Xuezhu; Goldhammer, Frank; Moosbrugger, Helfried; Schweizer, Karl

    2012-01-01

    The aim of the present study was to clarify the nature of the ability-specific and position-specific components of Raven's Advanced Progressive Matrices (APM) by relating them to a number of types of attention. The ability-specific component represents the constant part of cognitive performance whereas the position-specific component reflects the…

  19. Project Management in Behavioural Perspective – Cognitive Biases in the Formulation of the Aim of the Project

    Directory of Open Access Journals (Sweden)

    Kiełczewski Dariusz

    2016-09-01

    Full Text Available The article contains a behavioural analysis of the aim-formulating stage of the project. The purpose of the article is to point out that in the process of formulating the aim of the project, it comes to such decision-making situations which favour heuristic thinking. The article presents the results of the secondary research. As a result of verified theory, according to which in the process of formulating the aim of the project, the interference in decision-making processes may occur on the part of the heuristics and the resulting cognitive biases.

  20. The FOXO3A rs2802292 G-Allele Associates with Improved Peripheral and Hepatic Insulin Sensitivity and Increased Skeletal Muscle-FOXO3A mRNA Expression in Twins

    DEFF Research Database (Denmark)

    Banasik, Karina; Ribel-Madsen, Rasmus; Gjesing, Anette P

    2011-01-01

    Objective: The minor G-allele of FOXO3A rs2802292 has been associated with longevity. We aimed to investigate whether a phenotype related to healthy metabolic aging could be identified in individuals carrying the longevity-associated FOXO3A rs2802292 G-allele. Research Design and Methods: rs28022...