WorldWideScience

Sample records for space rocks kit

  1. Evaluating the Medical Kit System for the International Space Station(ISS) - A Paradigm Revisited

    Science.gov (United States)

    Hailey, Melinda J.; Urbina, Michelle C.; Hughlett, Jessica L.; Gilmore, Stevan; Locke, James; Reyna, Baraquiel; Smith, Gwyn E.

    2010-01-01

    Medical capabilities aboard the International Space Station (ISS) have been packaged to help astronaut crew medical officers (CMO) mitigate both urgent and non-urgent medical issues during their 6-month expeditions. Two ISS crewmembers are designated as CMOs for each 3-crewmember mission and are typically not physicians. In addition, the ISS may have communication gaps of up to 45 minutes during each orbit, necessitating medical equipment that can be reliably operated autonomously during flight. The retirement of the space shuttle combined with ten years of manned ISS expeditions led the Space Medicine Division at the NASA Johnson Space Center to reassess the current ISS Medical Kit System. This reassessment led to the system being streamlined to meet future logistical considerations with current Russian space vehicles and future NASA/commercial space vehicle systems. Methods The JSC Space Medicine Division coordinated the development of requirements, fabrication of prototypes, and conducted usability testing for the new ISS Medical Kit System in concert with implementing updated versions of the ISS Medical Check List and associated in-flight software applications. The teams constructed a medical kit system with the flexibility for use on the ISS, and resupply on the Russian Progress space vehicle and future NASA/commercial space vehicles. Results Prototype systems were developed, reviewed, and tested for implementation. Completion of Preliminary and Critical Design Reviews resulted in a streamlined ISS Medical Kit System that is being used for training by ISS crews starting with Expedition 27 (June 2011). Conclusions The team will present the process for designing, developing, , implementing, and training with this new ISS Medical Kit System.

  2. Training Educators to Teach the Sun and Space Weather Using a Kit of Tools

    Science.gov (United States)

    Keesee, A. M.; Ensign, T.

    2014-12-01

    NASA provides a wealth of data from Heliospheric missions to the public, but educators face several challenges to using such data in the classroom. These include the knowledge of what is available and how to use it, a full understanding of the science concepts the data demonstrate, ability to obtain and maintain products to access data, and access to technology (such as computer labs) for anything other than testing. To surmount these challenges, the Educator Resource Center at the NASA Independent Validation and Verification (IV&V) Center in Fairmont, WV has developed an operational model that focuses on housing, maintaining, and lending out kits of necessary equipment along with training educators in the science concepts and use of kit materials. Following this model, we have developed a Sun and Space Weather kit and an educator professional development course that we have presented several times. The kit includes a classroom set of iPads utilized to access data from NASA missions and other sources as well as create video reports for project based outcomes, a set of telescopes for safe solar viewing, and materials to explore magnetic fields and the electromagnetic spectrum. We will present an overview of the training course, the kit materials, and lessons learned.

  3. X-ray microtomography application in pore space reservoir rock.

    Science.gov (United States)

    Oliveira, M F S; Lima, I; Borghi, L; Lopes, R T

    2012-07-01

    Characterization of porosity in carbonate rocks is important in the oil and gas industry since a major hydrocarbons field is formed by this lithology and they have a complex media porous. In this context, this research presents a study of the pore space in limestones rocks by x-ray microtomography. Total porosity, type of porosity and pore size distribution were evaluated from 3D high resolution images. Results show that carbonate rocks has a complex pore space system with different pores types at the same facies. Copyright © 2011 Elsevier Ltd. All rights reserved.

  4. X-ray microtomography application in pore space reservoir rock

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, M.F.S.; Lima, I. [Nuclear Instrumentation Laboratory, COPPE/UFRJ, P.O. Box 68509, 21.941-972, Rio de Janeiro (Brazil); Borghi, L. [Geology Department, Geosciences Institute, Federal University of Rio de Janeiro, Brazil. (Brazil); Lopes, R.T., E-mail: ricardo@lin.ufrj.br [Nuclear Instrumentation Laboratory, COPPE/UFRJ, P.O. Box 68509, 21.941-972, Rio de Janeiro (Brazil)

    2012-07-15

    Characterization of porosity in carbonate rocks is important in the oil and gas industry since a major hydrocarbons field is formed by this lithology and they have a complex media porous. In this context, this research presents a study of the pore space in limestones rocks by x-ray microtomography. Total porosity, type of porosity and pore size distribution were evaluated from 3D high resolution images. Results show that carbonate rocks has a complex pore space system with different pores types at the same facies. - Highlights: Black-Right-Pointing-Pointer This study is about porosity parameter in carbonate rocks by 3D X-Ray Microtomography. Black-Right-Pointing-Pointer This study has become useful as data input for modeling reservoir characterization. Black-Right-Pointing-Pointer This technique was able to provide pores, grains and mineralogical differences among the samples.

  5. Create an Emergency Kit

    Science.gov (United States)

    ... models take up less space in your kit. Cell phone. Always carry a cell phone and let people know where you are going ... pump in your emergency kit. Remember that despite safety standards and careful monitoring, these devices can fail. ...

  6. ISS Expedition 08 Press Kit

    Data.gov (United States)

    National Aeronautics and Space Administration — Press kit for ISS mission Expedition 08 from 10/2003-04/2004. Press kits contain information about each mission overview, crew, mission timeline, benefits, and media...

  7. What Happens Where the Water and the Rock Touch in Small Space Bodies

    Science.gov (United States)

    Byrne, P. K.; Regensburger, P. V.; Klimczak, C.; Bohnenstiehl, D. R.; Dombard, A. J.; Hauck, S. A., II

    2017-12-01

    There are several small space bodies that go around bigger worlds that might have a layer of water under a layer of ice. Lots of study has been done to understand the outside ice layer of these small space bodies, because the ice can tells us important things about the big water layer under it. Some of these small space bodies are very interesting because the right things for life—water, hot rock, and food—might be at the bottom of the water layer, where it touches the top of the next layer down, which is made of rock. But it is very hard to understand what this rock at the bottom of the water is like, because we can't see it. So, we are imagining what this rock is like by thinking about what the rock is like under the water layer on our own world. If hot rock comes out of the rock layer through cracks under the water, the cold of the water makes the hot rock go very cold very fast, and it makes funny rolls as it does so. This might happen on some small space bodies that are hot enough on the inside to make hot rock. We know that on our own world the rock layer under the water is wet to as far down as cracks can go, so it makes sense that this is true for small space bodies, too. We did some thinking about numbers and found out that the cracks can go a few ten hundred steps into the rock layer on small space bodies, but for bigger (well, not quite so small) space bodies, the cracks can go at least tens of ten hundred steps into the rock layer. This means that water goes into the rock layer this much, too. But get this: some small bodies are not really that small—one of them is bigger than the first world from the Sun! And on a few of these big (small) bodies, the layer of water is so heavy that the bottom of that water is pushed together from all sides and turns into a type of hot ice. This means that, for these big (small) worlds, the water can't get into the rock layer through cracks (since there is a layer of hot ice in the way), and so these bodies are

  8. Alteration of Lunar Rock Surfaces through Interaction with the Space Environment

    Science.gov (United States)

    Frushour, A. M.; Noble, S. K; Christoffersen, R.; Keller, L P.

    2014-01-01

    Space weathering occurs on all ex-posed surfaces of lunar rocks, as well as on the surfaces of smaller grains in the lunar regolith. Space weather-ing alters these exposed surfaces primarily through the action of solar wind ions and micrometeorite impact processes. On lunar rocks specifically, the alteration products produced by space weathering form surface coatings known as patina. Patinas can have spectral reflectance properties different than the underlying rock. An understanding of patina composition and thickness is therefore important for interpreting re-motely sensed data from airless solar system bodies. The purpose of this study is to try to understand the physical and chemical properties of patina by expanding the number of patinas known and characterized in the lunar rock sample collection.

  9. Education Payload Operation - Kit D

    Science.gov (United States)

    Keil, Matthew

    2009-01-01

    Education Payload Operation - Kit D (EPO-Kit D) includes education items that will be used to support the live International Space Station (ISS) education downlinks and Education Payload Operation (EPO) demonstrations onboard the ISS. The main objective of EPO-Kit D supports the National Aeronautics and Space Administration (NASA) goal of attracting students to study and seek careers in science, technology, engineering, and mathematics.

  10. STUDY ON THE BLASTING SEISMIC DAMAGE CONTROL TECHNOLOGY FOR SMALL SPACING SOFT ROCK TUNNEL

    Directory of Open Access Journals (Sweden)

    Yang Chengzhong

    2017-07-01

    Full Text Available With a lot construction of transportation infrastructure in Chinese mountainous area, because of its unique advantages such as less land occupation, beautiful appearance and convenient route planning, small spacing tunnels are widely used. The shallow buried tunnel with small spacing, the blasting excavation will lead to tunnel surrounding rock especially in the middle rock wall damage and reduce the self-bearing capacity of surrounding rock. Through detecting and analyzing by the geological radar of the excavated red layer soft rock tunnel surrounding rock found that the middle rock wall loose circle thickness of the tunnel reaches to 1.8 m, the vault and sidewall loose circle thickness is about 1.2 m. Through selection of rational strengthening measures and blasting design scheme to improve drilling parameters and methods, as far as possible to protect the integrity and self-bearing capacity of the surrounding rock, the deformation and vibration of the tunnel would be controlled in reasonable limits and ensure the safety of tunnel construction.

  11. Pore Space Connectivity and the Transport Properties of Rocks

    Directory of Open Access Journals (Sweden)

    Bernabé Yves

    2016-07-01

    Full Text Available Pore connectivity is likely one of the most important factors affecting the permeability of reservoir rocks. Furthermore, connectivity effects are not restricted to materials approaching a percolation transition but can continuously and gradually occur in rocks undergoing geological processes such as mechanical and chemical diagenesis. In this study, we compiled sets of published measurements of porosity, permeability and formation factor, performed in samples of unconsolidated granular aggregates, in which connectivity does not change, and in two other materials, sintered glass beads and Fontainebleau sandstone, in which connectivity does change. We compared these data to the predictions of a Kozeny-Carman model of permeability, which does not account for variations in connectivity, and to those of Bernabé et al. (2010, 2011 model, which does [Bernabé Y., Li M., Maineult A. (2010 Permeability and pore connectivity: a new model based on network simulations, J. Geophys. Res. 115, B10203; Bernabé Y., Zamora M., Li M., Maineult A., Tang Y.B. (2011 Pore connectivity, permeability and electrical formation factor: a new model and comparison to experimental data, J. Geophys. Res. 116, B11204]. Both models agreed equally well with experimental data obtained in unconsolidated granular media. But, in the other materials, especially in the low porosity samples that had undergone the greatest amount of sintering or diagenesis, only Bernabé et al. model matched the experimental data satisfactorily. In comparison, predictions of the Kozeny-Carman model differed by orders of magnitude. The advantage of the Bernabé et al. model was its ability to account for a continuous, gradual reduction in pore connectivity during sintering or diagenesis. Although we can only speculate at this juncture about the mechanisms responsible for the connectivity reduction, we propose two possible mechanisms, likely to be active at different stages of sintering and diagenesis

  12. Collimator kit

    International Nuclear Information System (INIS)

    Jonker, R.R.

    1976-01-01

    A collimator kit having a number of parts which may be assembled in various combinations to provide focusing collimators with different performance characteristics for radioisotope imaging apparatus is described

  13. Reservoir Space Evolution of Volcanic Rocks in Deep Songliao Basin, China

    Science.gov (United States)

    Zheng, M.; Wu, X.; Zheng, M.; HU, J.; Wang, S.

    2015-12-01

    Recent years, large amount of natural gas has been discovered in volcanic rock of Lower Crataceous of Songliao basin. Volcanic reservoirs have become one of the important target reservoir types of eastern basin of China. In order to study the volcanic reservoirs, we need to know the main factors controlling the reservoir space. By careful obsercation on volcanic drilling core, casting thin sections and statistical analysis of petrophysical properties of volcanic reservoir in Songliao basin, it can be suggested that the igneous rock reservoir in Yingcheng formation of Lower Crataceous is composed of different rock types, such ad rohylite, rohylitic crystal tuff, autoclastic brecciation lava and so on. There are different reservoirs storage space in in various lithological igneous rocks, but they are mainly composed of primary stoma, secondary solution pores and fractures.The evolution of storage space can be divided into 3 stage: the pramary reservoir space,exogenic leaching process and burial diagenesis.During the evolution process, the reservoir space is effected by secondary minerals, tectonic movement and volcanic hydrothermal solution. The pore of volcanic reservoirs can be partially filled by secondary minerals, but also may be dissoluted by other chemical volcanic hydrothermal solution. Therefore, the favorable places for better-quality volcanic reservoirs are the near-crater facies of vocanic apparatus and dissolution zones on the high position of paleo-structures.

  14. Core Flight System Satellite Starter Kit

    Data.gov (United States)

    National Aeronautics and Space Administration — The Core Flight System Satellite Starter Kit (cFS Kit) will allow a small satellite or CubeSat developer to rapidly develop, deploy, test, and operate flight...

  15. Space Rocks Tell Their Secrets: Space Science Applications of Physics and Chemistry for High School and College Classes

    Science.gov (United States)

    Lindstrom, M. M.; Tobola, K. W.; Stocco, K.; Henry, M.; Allen, J. S.

    2003-01-01

    As the scientific community studies Mars remotely for signs of life and uses Martian meteorites as its only available samples, teachers, students, and the general public continue to ask, "How do we know these meteorites are from Mars?" This question sets the stage for a three-lesson instructional package Space Rocks Tell Their Secrets. Expanding on the short answer "It's the chemistry of the rock", students are introduced to the research that reveals the true identities of the rocks. Since few high school or beginning college students have the opportunity to participate in this level of research, a slide presentation introduces them to the labs, samples, and people involved with the research. As they work through the lessons and interpret real data, students realize that the research is an application of basic science concepts they should know, the electromagnetic spectrum and isotopes. They can understand the results without knowing how to do the research or operate the instruments.

  16. Space Rocks Tell Their Secrets: Space Science Applications of Physics and Chemistry for High School and College Classes. Update.

    Science.gov (United States)

    Lindstrom, M. M.; Tobola, K. W.; Allen, J. S.; Stocco, K.; Henry, M.; Allen, J. S.; McReynolds, Julie; Porter, T. Todd; Veile, Jeri

    2005-01-01

    As the scientific community studies Mars remotely for signs of life and uses Martian meteorites as its only available samples, teachers, students, and the general public continue to ask, "How do we know these meteorites are from Mars?" This question sets the stage for a six-lesson instructional package Space Rocks Tell Their Secrets. Expanding on the short answer "It's the chemistry of the rock", students are introduced to the research that reveals the true identities of the rocks. Since few high school or beginning college students have the opportunity to participate in this level of research, a slide presentation introduces them to the labs, samples, and people involved with the research. As they work through the lessons and interpret authentic data, students realize that the research is an application of two basic science concepts taught in the classroom, the electromagnetic spectrum and isotopes. Additional information is included in the original extended abstract.

  17. Space Rocks Tell Their Secrets: Space Science Applications of Physics and Chemistry for High School and College Classes: Update

    Science.gov (United States)

    Lindstrom, M. M.; Tobola, K. W.; Stocco, K.; Henry, M.; Allen, J. S.; McReynolds, Julie; Porter, T. Todd; Veile, Jeri

    2004-01-01

    As the scientific community studies Mars remotely for signs of life and uses Martian meteorites as its only available samples, teachers, students, and the general public continue to ask, How do we know these meteorites are from Mars? This question sets the stage for a six-lesson instructional package Space Rocks Tell Their Secrets. Expanding on the short answer It s the chemistry of the rock , students are introduced to the research that reveals the true identities of the rocks. Since few high school or beginning college students have the opportunity to participate in this level of research, a slide presentation introduces them to the labs, samples, and people involved with the research. As they work through the lessons and interpret authentic data, students realize that the research is an application of two basic science concepts taught in the classroom, the electromagnetic spectrum and isotopes.

  18. An Examination of the Space Weathering Patina of Lunar Rock 76015

    Science.gov (United States)

    Noble, S.; Chrisoffersen, R.; Rahman, Z.

    2011-01-01

    Space weathering discussions have generally centered around soils but exposed rocks will also incur the effects of weathering. Rocks have much longer surface lifetimes than an individual soil grain and thus record a longer history of exposure. By studying the weathering products which have built up on a rock surface, we can gain a deeper perspective on the weathering process and better assess the relative importance of various weathering components. The weathered coating, or patina, of the lunar rock 76015 has been previously studied under SEM and also by TEM using ultramicrotome sample preparation methods. However, to really understand the products involved in creating these coatings, it is helpful to examine the patina in cross section, something which is now possible though the use of Focused Ion Beam (FIB) sample prep techniques, which allows us to preserve intact the delicate stratigraphy of the patina coating and provides a unique cross-sectional view of the space weathering process. Several samples have been prepared from the rock and the coatings are found to be quite variable in thickness and composition from one sample to the next.

  19. NASA Lunar Sample Education Disk Program - Space Rocks for Classrooms, Museums, Science Centers and Libraries

    Science.gov (United States)

    Allen, J. S.

    2009-12-01

    NASA is eager for students and the public to experience lunar Apollo rocks and regolith soils first hand. Lunar samples embedded in plastic are available for educators to use in their classrooms, museums, science centers, and public libraries for education activities and display. The sample education disks are valuable tools for engaging students in the exploration of the Solar System. Scientific research conducted on the Apollo rocks has revealed the early history of our Earth-Moon system. The rocks help educators make the connections to this ancient history of our planet as well as connections to the basic lunar surface processes - impact and volcanism. With these samples educators in museums, science centers, libraries, and classrooms can help students and the public understand the key questions pursued by missions to Moon. The Office of the Curator at Johnson Space Center is in the process of reorganizing and renewing the Lunar and Meteorite Sample Education Disk Program to increase reach, security and accountability. The new program expands the reach of these exciting extraterrestrial rocks through increased access to training and educator borrowing. One of the expanded opportunities is that trained certified educators from science centers, museums, and libraries may now borrow the extraterrestrial rock samples. Previously the loan program was only open to classroom educators so the expansion will increase the public access to the samples and allow educators to make the critical connections of the rocks to the exciting exploration missions taking place in our solar system. Each Lunar Disk contains three lunar rocks and three regolith soils embedded in Lucite. The anorthosite sample is a part of the magma ocean formed on the surface of Moon in the early melting period, the basalt is part of the extensive lunar mare lava flows, and the breccias sample is an important example of the violent impact history of the Moon. The disks also include two regolith soils and

  20. Rocking Rotation of a Rigid Disk Embedded in a Transversely Isotropic Half-Space

    Directory of Open Access Journals (Sweden)

    Seyed Ahmadi

    2014-06-01

    Full Text Available The asymmetric problem of rocking rotation of a circular rigid disk embedded in a finite depth of a transversely isotropic half-space is analytically addressed. The rigid disk is assumed to be in frictionless contact with the elastic half-space. By virtue of appropriate Green's functions, the mixed boundary value problem is written as a dual integral equation. Employing further mathematical techniques, the integral equation is reduced to a well-known Fredholm integral equation of the second kind. The results related to the contact stress distribution across the disk region and the equivalent rocking stiffness of the system are expressed in terms of the solution of the obtained Fredholm  integral  equation. When the rigid disk is located on the surface or at the remote boundary, the exact closed-form solutions are presented. For verification purposes, the limiting case of an isotropic half-space is considered and the results are verified with those available in the literature. The jump behavior in the results at the edge of the rigid disk for the case of an infinitesimal embedment is highlighted analytically for the first time. Selected numerical results are depicted for the contact stress distribution across the disk region, rocking stiffness of the system, normal stress, and displacement components along the radial axis. Moreover, effects of anisotropy on the rocking stiffness factor are discussed in detail.

  1. Rock fragmentation

    Energy Technology Data Exchange (ETDEWEB)

    Brown, W.S.; Green, S.J.; Hakala, W.W.; Hustrulid, W.A.; Maurer, W.C. (eds.)

    1976-01-01

    Experts in rock mechanics, mining, excavation, drilling, tunneling and use of underground space met to discuss the relative merits of a wide variety of rock fragmentation schemes. Information is presented on novel rock fracturing techniques; tunneling using electron beams, thermocorer, electric spark drills, water jets, and diamond drills; and rock fracturing research needs for mining and underground construction. (LCL)

  2. Using the Planetary Science Institute’s Meteorite Mini-Kits to Address the Nature of Science

    Science.gov (United States)

    Lebofsky, Larry A.; Cañizo, Thea L.; Buxner, Sanlyn

    2014-11-01

    Hands-on learning allows students to understand science concepts by directly observing and experiencing the topics they are studying. The Planetary Science Institute (PSI) has created instructional rock kits that have been introduced to elementary and middle school teachers in Tucson, in our professional development workshops. PSI provides teachers with supporting material and training so that they can use the kits as tools for students’ hands-on learning. Use of these kits provides an important experience with natural materials that is essential to instruction in Earth and Space Science. With a stronger knowledge of science content and of how science is actually conducted, the workshops and kits have instilled greater confidence in teachers’ ability to teach science content. The Next Generation Science Standards (NGSS) Performance Expectations includes: “What makes up our solar system?” NGSS emphasizes the Crosscutting Concepts—Patterns Scale, Portion, and Quantity; and Systems and System Models. NGSS also states that the Nature of Science (NOS) should be an “essential part” of science education. NOS topics include understanding that scientific investigations use a variety of methods, that scientific knowledge is based on empirical evidence, that scientific explanations are open to revision in light of new evidence, and an understanding of the nature of scientific models.Addressing a need expressed by teachers for borrowing kits less expensive than our $2000 option, we created a Meteorite Mini-Kit. Each Mini-Kit contains eight rocks: an iron-bearing chondrite, a sliced chondrite (showing iron and chondrules), a tektite, a common Tucson rock, a river-polished rock, pumice, a small iron, and a rounded obsidian rock (false tektite). Also included in the Mini-Kits are magnets and a magnifier. The kits cost $40 to $50, depending on the sizes of the chondrites. A teacher can check out a classroom set of these which contains either 10 or 20 Mini-Kits. Each

  3. Analyzer for measuring gas contained in the pore space of rocks

    Science.gov (United States)

    Kudasik, Mateusz; Skoczylas, Norbert

    2017-10-01

    In the present paper, the authors discussed the functioning of their own analyzer for measuring gas contained in the pore space of high strength rocks. A sample is placed inside a hermetic measuring chamber, and then undergoes impact milling as a result of colliding with the vibrating blade of a knife which is rotationally driven by a high-speed brushless electric motor. The measuring chamber is equipped with all the necessary sensors, i.e. gas, pressure, and temperature sensors. Trial tests involving the comminution of dolomite and anhydrite samples demonstrated that the constructed device is able to break up rocks into grains so fine that they are measured in single microns, and the sensors used in the construction ensure balancing of the released gas. The tests of the analyzer showed that the metrological concept behind it, together with the way it was built, make it fit for measurements of the content and composition of selected gases from the rock pore space. On the basis of the conducted tests of balancing the gases contained in the two samples, it was stated that the gas content of Sample no. 1 was (0.055  ±  0.002) cm3 g-1, and Sample no. 2 contained gas at atmospheric pressure, composed mostly of air.

  4. Old flying ice-rock body in space allows a glance at its inner working.

    Science.gov (United States)

    Bieler, A. M.

    2015-12-01

    I am studying old, cold bodies of rock and ice flying through space, usually far, far away from the Sun. They are even behind the last of the big 8 balls we call our home worlds. (There were 9 balls a few yearsago, but then one of the balls was not considered a ball anymore by some people and he/she had to leave the group.)Because they are so far away from the Sun, they remain dark and very cold for the most part of their life.That is why even most of the very nervous stuff sticks on them ever since. With stuff I mean the little things that the Sun, the big 8 balls, we humans and everything else that is flying around the Sun ismade of. The nervous ones quickly change into something wind like andcan get lost. But the cold on the ice-rock bodies slows this down andthey stick around. This makes those ice-rock bodies interesting tostudy, they did not change too much since they were made.I study news sent back from a computer controlled box flying around oneof those rock-ice things that is now closer to the Sun. When thespace between such a body and the Sun gets smaller, it warms up andsome of the ice changes into wind like things. We find out how muchof what stuff is flying away from that body and at what time.Then I and my friends put those numbers into a big ass computer to findout more on how those rock-ice bodies work. Where does the wind comefrom? Do they all come from the same place or only some? Is it really the Sun's fault? How many cups of ice change into wind each day? Many questions.

  5. Numerical Simulation and Optimization of Hole Spacing for Cement Grouting in Rocks

    Directory of Open Access Journals (Sweden)

    Ping Fu

    2013-01-01

    Full Text Available The fine fissures of V-diabase were the main stratigraphic that affected the effectiveness of foundation grout curtain in Dagang Mountain Hydropower Station. Thus, specialized in situ grouting tests were conducted to determine reasonable hole spacing and other parameters. Considering time variation of the rheological parameters of grout, variation of grouting pressure gradient, and evolution law of the fracture opening, numerical simulations were performed on the diffusion process of cement grouting in the fissures of the rock mass. The distribution of permeability after grouting was obtained on the basis of analysis results, and the grouting hole spacing was discussed based on the reliability analysis. A probability of optimization along with a finer optimization precision as 0.1 m could be adopted when compared with the accuracy of 0.5 m that is commonly used. The results could provide a useful reference for choosing reasonable grouting hole spacing in similar projects.

  6. Electromagnetic Emissions During Rock-fracturing Experiments Inside Magnetic Field Free Space

    Science.gov (United States)

    Wang, H.; Zhou, J.; Zhu, T.; Jin, H.

    2012-12-01

    Abnormal electromagnetic emission (EME) signal is one type of the most important precursors before earthquake, which has been widely observed and recorded before large earthquake, but the physical mechanism underlying the phenomenon is unclear and under controversy. Monitoring the EME signals during rock-fracturing experiments in laboratory is an effective way to study the phenomena and their underlying mechanism. Electromagnetic noise is everywhere because industrial and civilian electrical equipments have been widely used, which make difficulties to the in-lab experiments and field monitoring. To avoid the interference from electromagnetic noise, electromagnetic experiments must be carried out inside shielded space. Magnetic Field Free Space (MFFS) was constructed by Institute of Geophysics, China Earthquake Administration in 1980s. MFFS is a near-spherical polyhedron 'space' with 26 faces and inside diameter about 2.3 m. It is enclosed by 8-layer permalloy 1J85 for shielding magnetic field and 2-layer purified aluminium for shielding electric field. MFFS mainly shields static magnetic field by a factor of 160-4000 for the magnetic signals with the frequencies ranging from 0.01 Hz to 10 Hz. The intensity of magnetic field inside the space is less than 20 nT and its fluctuation is less than 0.3 nT in 90 hours. MFFS can dramatically shield EME signals in the frequency range of EME antennas utilized in our experiments, (several to ~320) kHz, by at least 90%, based on observation. Rock specimens (granite, marble) were fractured by two ways inside MFFS. 1) Cuboid bulk specimens were drilled, filled with static cracking agent, and then dilated from inside until fracture. 2) Cylindrical rock specimens were stressed until fracture by using a non-magnetic rock testing machine with the maximum testing force 300kN. EME, acoustic emission (AE) and strain signals were collected synchronously by the same data acquisitor, Acoustic Emission Workstation made by Physical Acoustics

  7. Lunar and Meteorite Sample Education Disk Program - Space Rocks for Classrooms, Museums, Science Centers, and Libraries

    Science.gov (United States)

    Allen, Jaclyn; Luckey, M.; McInturff, B.; Huynh, P.; Tobola, K.; Loftin, L.

    2010-01-01

    NASA is eager for students and the public to experience lunar Apollo samples and meteorites first hand. Lunar rocks and soil, embedded in Lucite disks, are available for educators to use in their classrooms, museums, science centers, and public libraries for education activities and display. The sample education disks are valuable tools for engaging students in the exploration of the Solar System. Scientific research conducted on the Apollo rocks reveals the early history of our Earth-Moon system and meteorites reveal much of the history of the early solar system. The rocks help educators make the connections to this ancient history of our planet and solar system and the basic processes accretion, differentiation, impact and volcanism. With these samples, educators in museums, science centers, libraries, and classrooms can help students and the public understand the key questions pursued by many NASA planetary missions. The Office of the Curator at Johnson Space Center is in the process of reorganizing and renewing the Lunar and Meteorite Sample Education Disk Program to increase reach, security and accountability. The new program expands the reach of these exciting extraterrestrial rocks through increased access to training and educator borrowing. One of the expanded opportunities is that trained certified educators from science centers, museums, and libraries may now borrow the extraterrestrial rock samples. Previously the loan program was only open to classroom educators so the expansion will increase the public access to the samples and allow educators to make the critical connections to the exciting exploration missions taking place in our solar system. Each Lunar Disk contains three lunar rocks and three regolith soils embedded in Lucite. The anorthosite sample is a part of the magma ocean formed on the surface of Moon in the early melting period, the basalt is part of the extensive lunar mare lava flows, and the breccias sample is an important example of the

  8. Novel Rock Detection Intelligence for Space Exploration Based on Non-Symbolic Algorithms and Concepts

    Science.gov (United States)

    Yildirim, Sule; Beachell, Ronald L.; Veflingstad, Henning

    2007-01-01

    Future space exploration can utilize artificial intelligence as an integral part of next generation space rover technology to make the rovers more autonomous in performing mission objectives. The main advantage of the increased autonomy through a higher degree of intelligence is that it allows for greater utilization of rover resources by reducing the frequency of time consuming communications between rover and earth. In this paper, we propose a space exploration application of our research on a non-symbolic algorithm and concepts model. This model is based on one of the most recent approaches of cognitive science and artificial intelligence research, a parallel distributed processing approach. We use the Mars rovers. Sprit and Opportunity, as a starting point for proposing what rovers in the future could do if the presented model of non-symbolic algorithms and concepts is embedded in a future space rover. The chosen space exploration application for this paper, novel rock detection, is only one of many potential space exploration applications which can be optimized (through reduction of the frequency of rover-earth communications. collection and transmission of only data that is distinctive/novel) through the use of artificial intelligence technology compared to existing approaches.

  9. Paradise regained: older adult rock climbers turning space into place in the natural environment

    Directory of Open Access Journals (Sweden)

    Mark Hickman

    2015-12-01

    Full Text Available At the time of writing there are over 10 million people aged over 65 living in the UK, and by 2050 the number is predicted to rise to 19 million. This expansion of the ageing population is mirrored worldwide, and over the past ten years has stimulated a growth in age-related studies. However, the idea of a social gerontology of the outdoors is yet to take root. Yet, with the maturing of those born between the years 1946 and 1964, and increased participation in adventurous activities, we suggest that the time is right for scholarship in this specific direction. Accordingly, the aim of this study was to discover how older adult rock climbers perceived their relationship with the natural environment to have changed over the period of their involvement with rock climbing. The investigation used a purposive sample of rock climbers in the north-west of England (n=10 aged between 65 and 74 years (av=69.6 identifying them as ‘young-old’ adults. Oral testimony was collected over two phases, the first with interview-questionnaires, and the second with targeted semi-structured interviews. In order to give a clear voice to participants, manual data handling using was used to establish raw data that were then sorted into themes and verified against internal and external checkers. These were then organized around Peace, Wahl, Mollenkopf and Oswald’s (2014 concept of an ‘environment’ considered within three dimensions: the physical/material, including the natural landscape; the psychological, and the meaning attributed to the place, its evolution across the life course, and how it makes people feel about themselves; and the social/cultural, involving the engagement of people to places, including how the space is used and remembered.

  10. First aid kit

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/001958.htm First aid kit To use the sharing features on this ... ahead, you can create a well-stocked home first aid kit. Keep all of your supplies in one ...

  11. Two-dimensional T2 distribution mapping in rock core plugs with optimal k-space sampling.

    Science.gov (United States)

    Xiao, Dan; Balcom, Bruce J

    2012-07-01

    Spin-echo single point imaging has been employed for 1D T(2) distribution mapping, but a simple extension to 2D is challenging since the time increase is n fold, where n is the number of pixels in the second dimension. Nevertheless 2D T(2) mapping in fluid saturated rock core plugs is highly desirable because the bedding plane structure in rocks often results in different pore properties within the sample. The acquisition time can be improved by undersampling k-space. The cylindrical shape of rock core plugs yields well defined intensity distributions in k-space that may be efficiently determined by new k-space sampling patterns that are developed in this work. These patterns acquire 22.2% and 11.7% of the k-space data points. Companion density images may be employed, in a keyhole imaging sense, to improve image quality. T(2) weighted images are fit to extract T(2) distributions, pixel by pixel, employing an inverse Laplace transform. Images reconstructed with compressed sensing, with similar acceleration factors, are also presented. The results show that restricted k-space sampling, in this application, provides high quality results. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Characterising rock fracture aperture-spacing relationships using power-law relationships: some considerations

    Science.gov (United States)

    Brook, Martin; Hebblewhite, Bruce; Mitra, Rudrajit

    2016-04-01

    The size-scaling of rock fractures is a well-studied problem in geology, especially for permeability quantification. The intensity of fractures may control the economic exploitation of fractured reservoirs because fracture intensity describes the abundance of fractures potentially available for fluid flow. Moreover, in geotechnical engineering, fractures are important for parameterisation of stress models and excavation design. As fracture data is often collected from widely-spaced boreholes where core recovery is often incomplete, accurate interpretation and representation of fracture aperture-frequency relationships from sparse datasets is important. Fracture intensity is the number of fractures encountered per unit length along a sample scanline oriented perpendicular to the fractures in a set. Cumulative frequency of fractures (F) is commonly related to fracture aperture (A) in the form of a power-law (F = aA-b), with variations in the size of the a coefficient between sites interpreted to equate to fracture frequency for a given aperture (A). However, a common flaw in this approach is that even a small change in b can have a large effect on the response of the fracture frequency (F) parameter. We compare fracture data from the Late Permian Rangal Coal Measures from Australia's Bowen Basin, with fracture data from Jurassic carbonates from the Sierra Madre Oriental, northeastern Mexico. Both power-law coefficient a and exponent b control the fracture aperture-frequency relationship in conjunction with each other; that is, power-laws with relatively low a coefficients have relatively high b exponents and vice versa. Hence, any comparison of different power-laws must take both a and b into consideration. The corollary is that different sedimentary beds in the Sierra Madre carbonates do not show ˜8× the fracture frequency for a given fracture aperture, as based solely on the comparison of coefficient a. Rather, power-law "sensitivity factors" developed from both

  13. Exploit Kit traffic analysis

    OpenAIRE

    Καπίρης, Σταμάτης; Kapiris, Stamatis

    2017-01-01

    Exploit kits have become one of the most widespread and destructive threat that Internet users face on a daily basis. Since the first actor, which has been categorized as exploit kit, namely MPack, appeared in 2006, we have seen a new era on exploit kit variants compromising popular websites, infecting hosts and delivering destructive malware, following an exponentially evolvement to date. With the growing threat landscape, large enterprises to domestic networks, have starte...

  14. Modelling the diffusion-available pore space of an unaltered granitic rock matrix using a micro-DFN approach

    Science.gov (United States)

    Svensson, Urban; Löfgren, Martin; Trinchero, Paolo; Selroos, Jan-Olof

    2018-04-01

    In sparsely fractured rock, the ubiquitous heterogeneity of the matrix, which has been observed in different laboratory and in situ experiments, has been shown to have a significant influence on retardation mechanisms that are of importance for the safety of deep geological repositories for nuclear waste. Here, we propose a conceptualisation of a typical heterogeneous granitic rock matrix based on micro-Discrete Fracture Networks (micro-DFN). Different sets of fractures are used to represent grain-boundary pores as well as micro fractures that transect different mineral grains. The micro-DFN model offers a great flexibility in the way inter- and intra-granular space is represented as the different parameters that characterise each fracture set can be fine tuned to represent samples of different characteristics. Here, the parameters of the model have been calibrated against experimental observations from granitic rock samples taken at Forsmark (Sweden) and different variant cases have been used to illustrate how the model can be tied to rock samples with different attributes. Numerical through-diffusion simulations have been carried out to infer the bulk properties of the model as well as to compare the computed mass flux with the experimental data from an analogous laboratory experiment. The general good agreement between the model results and the experimental observations shows that the model presented here is a reliable tool for the understanding of retardation mechanisms occurring at the mm-scale in the matrix.

  15. Benchmarking Tool Kit.

    Science.gov (United States)

    Canadian Health Libraries Association.

    Nine Canadian health libraries participated in a pilot test of the Benchmarking Tool Kit between January and April, 1998. Although the Tool Kit was designed specifically for health libraries, the content and approach are useful to other types of libraries as well. Used to its full potential, benchmarking can provide a common measuring stick to…

  16. Automated monitoring and forecasting of rock fall danger in space and time: practical field experience

    Czech Academy of Sciences Publication Activity Database

    Zvelebil, J.; Nechyba, M.; Paluš, Milan

    2008-01-01

    Roč. 10, - (2008), A-04352 ISSN 1029-7006. [General Asembly of the European Geophysical Society. 13.04.2008-18.04.2008, Vienna] R&D Projects: GA AV ČR 1ET110190504 Institutional research plan: CEZ:AV0Z10300504 Keywords : fractal * scaling * unstable rock slope * collapse prediction * engineering geology Subject RIV: DG - Athmosphere Sciences, Meteorology

  17. The challenges of lean manufacturing implementation in kitting assembly

    Science.gov (United States)

    Fansuri, A. F. H.; Rose, A. N. M.; Nik Mohamed, N. M. Z.; Ahmad, H.

    2017-10-01

    Literature studies shows that lean manufacturing goes way back with the original founder Eli Whitney in year 1799. The main purpose of lean manufacturing is to identify and eliminate waste in production. The application of lean manufacturing can be carried out in any industrial processes with regards to the understanding of lean principles, theories and practices. Kitting is one of the important aspects in a successful production. The continuous supply of materials from store to production has to be systematic and able to achieve lean standard for it to be successful. The objective of this paper is to review the implementation of lean manufacturing in kitting assembly. Previous papers show that, the implementation of lean manufacturing in kitting assembly may be beneficial to the organization such as reduce in space occupancy, part shortages, lead time and manpower. Based on previous research, some industries may tend to change between kitting and line stocking which are due to lack of understanding when implementing kitting and causes longer lead time and materials overflow in store. With a proper understanding on what to kit, where to kit, how to kit, why to kit and who kits the material with a standardised process flow may ensure the success of kitting.

  18. Self-gated 4D multiphase, steady-state imaging with contrast enhancement (MUSIC) using rotating cartesian K-space (ROCK): Validation in children with congenital heart disease.

    Science.gov (United States)

    Han, Fei; Zhou, Ziwu; Han, Eric; Gao, Yu; Nguyen, Kim-Lien; Finn, J Paul; Hu, Peng

    2017-08-01

    To develop and validate a cardiac-respiratory self-gating strategy for the recently proposed multiphase steady-state imaging with contrast enhancement (MUSIC) technique. The proposed SG strategy uses the ROtating Cartesian K-space (ROCK) sampling, which allows for retrospective k-space binning based on motion surrogates derived from k-space center line. The k-space bins are reconstructed using a compressed sensing algorithm. Ten pediatric patients underwent cardiac MRI for clinical reasons. The original MUSIC and 2D-CINE images were acquired as a part of the clinical protocol, followed by the ROCK-MUSIC acquisition, all under steady-state intravascular distribution of ferumoxytol. Subjective scores and image sharpness were used to compare the images of ROCK-MUSIC and original MUSIC. All scans were completed successfully without complications. The ROCK-MUSIC acquisition took 5 ± 1 min, compared to 8 ± 2 min for the original MUSIC. Image scores of ROCK-MUSIC were significantly better than original MUSIC at the ventricular outflow tracts (3.9 ± 0.3 vs. 3.3 ± 0.6, P ROCK-MUSIC in the other anatomic locations. ROCK-MUSIC provided images of equal or superior image quality compared to original MUSIC, and this was achievable with 40% savings in scan time and without the need for physiologic signal. Magn Reson Med 78:472-483, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  19. Method, equipment and results of determination of element composition of the Venus rock by the Vega-2 space probe

    International Nuclear Information System (INIS)

    Surkov, Yu.A.; Moskaleva, L.P.; Shcheglov, O.P.

    1985-01-01

    Venus rock composition was determined by X-ray radiometric method in the northeast site of the Aphrodita terra. The experiment was performed on the Vega-2 spacecraft. Composition of Venus rock proved to be close to the composition of the anorthosite-norite-troctolite rocks widespread in the lunar highland crust. The descriptions of the method, instrumentation and results of determining the composition of rocks in landing site of Vega-2 spacecraft are given

  20. Shuttle Kit Freezer Refrigeration Unit Conceptual Design

    Science.gov (United States)

    Copeland, R. J.

    1975-01-01

    The refrigerated food/medical sample storage compartment as a kit to the space shuttle orbiter is examined. To maintain the -10 F in the freezer kit, an active refrigeration unit is required, and an air cooled Stirling Cycle refrigerator was selected. The freezer kit contains two subsystems, the refrigeration unit, and the storage volume. The freezer must provide two basic capabilities in one unit. One requirement is to store 215 lbs of food which is consumed in a 30-day period by 7 people. The other requirement is to store 128.3 lbs of medical samples consisting of both urine and feces. The unit can be mounted on the lower deck of the shuttle cabin, and will occupy four standard payload module compartments on the forward bulkhead. The freezer contains four storage compartments.

  1. Personalized Thematic Kits

    Science.gov (United States)

    Bontrager, Sharon

    2010-01-01

    Teaching Spanish at the K-5 level is a passion of mine, and the author would like to share some of the practical applications that she finds most rewarding and effective. She has found enthusiastic response to the creation of detailed language learning kits that are rooted in storytelling, but expanded to include home-made board games,…

  2. World Disarmament Kit.

    Science.gov (United States)

    Woito, Robert, Ed.

    This kit presents a comprehensive introduction for students to arms control and disarmament issues. Included are copies of published and unpublished articles for each topic. Section I provides a self-survey to enable students to assess their own attitudes, values, and knowledge. The survey poses questions for which students select one of several…

  3. 49 CFR 173.161 - Chemical kits and first aid kits.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Chemical kits and first aid kits. 173.161 Section... Class 7 § 173.161 Chemical kits and first aid kits. (a) Chemical kits and First aid kits must conform to... 10 kg. (b) Chemical kits and First aid kits are excepted from the specification packaging...

  4. Build an Emergency Preparedness Kit

    Science.gov (United States)

    ... In addition to the items listed above, a vehicle kit should include: -fire extinguisher. -booster cables and tow rope. -compass and road maps. -shovel. -tire repair kit and pump. -extra clothing to keep dry. - ...

  5. NanoRocks: Design and performance of an experiment studying planet formation on the International Space Station

    Science.gov (United States)

    Brisset, Julie; Colwell, Joshua; Dove, Adrienne; Maukonen, Doug

    2017-07-01

    In an effort to better understand the early stages of planet formation, we have developed a 1.5U payload that flew on the International Space Station (ISS) in the NanoRacks NanoLab facility between September 2014 and March 2016. This payload, named NanoRocks, ran a particle collision experiment under long-term microgravity conditions. The objectives of the experiment were (a) to observe collisions between mm-sized particles at relative velocities of acrylic, glass, and copper beads and 0.75 mm-sized JSC-1 lunar regolith simulant grains. The particles were placed in sample cells carved out of an aluminum tray. This tray was attached to one side of the payload casing with three springs. Every 60 s, the tray was agitated, and the resulting collisions between the particles in the sample cells were recorded by the experiment camera. During the 18 months the payload stayed on ISS, we obtained 158 videos, thus recording a great number of collisions. The average particle velocities in the sample cells after each shaking event were around 1 cm/s. After shaking stopped, the inter-particle collisions damped the particle kinetic energy in less than 20 s, reducing the average particle velocity to below 1 mm/s, and eventually slowing them to below our detection threshold. As the particle velocity decreased, we observed the transition from bouncing to sticking collisions. We recorded the formation of particle clusters at the end of each experiment run. This paper describes the design and performance of the NanoRocks ISS payload.

  6. Rocking or rolling--perception of ambiguous motion after returning from space.

    Directory of Open Access Journals (Sweden)

    Gilles Clément

    Full Text Available The central nervous system must resolve the ambiguity of inertial motion sensory cues in order to derive an accurate representation of spatial orientation. Adaptive changes during spaceflight in how the brain integrates vestibular cues with other sensory information can lead to impaired movement coordination, vertigo, spatial disorientation, and perceptual illusions after return to Earth. The purpose of this study was to compare tilt and translation motion perception in astronauts before and after returning from spaceflight. We hypothesized that these stimuli would be the most ambiguous in the low-frequency range (i.e., at about 0.3 Hz where the linear acceleration can be interpreted either as a translation or as a tilt relative to gravity. Verbal reports were obtained in eleven astronauts tested using a motion-based tilt-translation device and a variable radius centrifuge before and after flying for two weeks on board the Space Shuttle. Consistent with previous studies, roll tilt perception was overestimated shortly after spaceflight and then recovered with 1-2 days. During dynamic linear acceleration (0.15-0.6 Hz, ±1.7 m/s2 perception of translation was also overestimated immediately after flight. Recovery to baseline was observed after 2 days for lateral translation and 8 days for fore-aft translation. These results suggest that there was a shift in the frequency dynamic of tilt-translation motion perception after adaptation to weightlessness. These results have implications for manual control during landing of a space vehicle after exposure to microgravity, as it will be the case for human asteroid and Mars missions.

  7. Preliminary results of the determination of the Venus rock comsposition by ''Venera 13'' and ''Venera 14'' space probes

    International Nuclear Information System (INIS)

    Surkov, Yu.A.; Moskaleva, L.P.; Shcheglov, O.P.; Kharyukova, V.P.; Manvelyan, O.S.; Smirnov, G.G.

    1982-01-01

    Composition of the rocks on Venus was determined for the first time. The determination of rock composition was carried out at the landing sites of Venera 13 and Venera 14. The rock samples analyzed by the X-ray radiometri.c method. The study of rocks was carried out in most typical of the surface of Venus provinces: rolling upland (Venera 13) and flat lowland (Venera 14). The rock composition at the Venera 13 landing site proved to be close to potassium alkaline basalt, that at the Venera 14 landing site close to tholeitic basalt of the Earth's crust. The comparison of the typical composition of Venus rocks with the composition of rocks of the same structural-morphological provinces of the Earth sws some differences in formation of the surface and the crust of those planets

  8. Irradiation and accretion of solids in space based on observations of lunar rocks and grains

    International Nuclear Information System (INIS)

    Lal, D.

    1977-01-01

    Clues to a wide range of questions relating to the origin and evolution of the solar system and dynamic physical and electromagnetic processes occurring concurrently and in the past in our galaxy have been provided by a study of the lunar samples. This information is deduced from a variety of complementary physical and chemical evidence. In this presentation greatest emphasis is laid on information based on effects arising from interactions of low energy cosmic rays with lunar surface materials. The present discussions concern the nature of experimental data to date and implications thereof to the charged particle environment of the Moon, ancient magnetic fields and the nature of time scales involved in the irradiation and accretion of solids in space, based on lunar regolith dynamics. It becomes clear that there does not yet exist any consensus on the absolute values of charged particle or the meteorite fluxes, and also about the details of the evolution of the lunar regolith. The complex history of evolution of lunar material is slowly being understood and it is hoped that a great deal of quantitative information will soon be available which will in turn allow discussion of evolution of solid bodies in the solar system. (author)

  9. Life in a rock pool: Radiation and population genetics of myxozoan parasites in hosts inhabiting restricted spaces.

    Science.gov (United States)

    Bartošová-Sojková, Pavla; Lövy, Alena; Reed, Cecile C; Lisnerová, Martina; Tomková, Tereza; Holzer, Astrid S; Fiala, Ivan

    2018-01-01

    Intertidal rock pools where fish and invertebrates are in constant close contact due to limited space and water level fluctuations represent ideal conditions to promote life cycles in parasites using these two alternate hosts and to study speciation processes that could contribute to understanding the roles of parasitic species in such ecosystems. Gall bladder and liver samples from five clinid fish species (Blenniiformes: Clinidae) were morphologically and molecularly examined to determine the diversity, prevalence, distribution and host specificity of Ceratomyxa parasites (Cnidaria: Myxozoa) in intertidal habitats along the coast of South Africa. Phylogenetic relationships of clinid ceratomyxids based on the SSU rDNA, LSU rDNA and ITS regions were assessed additionally to the investigation of population genetic structure of Ceratomyxa cottoidii and subsequent comparison with the data known from type fish host Clinus cottoides. Seven Ceratomyxa species including previously described Ceratomyxa dehoopi and C. cottoidii were recognized in clinids. They represent a diverse group of rapidly evolving, closely related species with a remarkably high prevalence in their hosts, little host specificity and frequent concurrent infections, most probably as a result of parasite radiation after multiple speciation events triggered by limited host dispersal within restricted spaces. C. cottoidii represents the most common clinid parasite with a population structure characterized by young expanding populations in the south west and south east coast and by older populations in equilibrium on the west coast of its distribution. Parasite and fish host population structures show overlapping patterns and are very likely affected by similar oceanographic barriers possibly due to reduced host dispersal enhancing parasite community differentiation. While fish host specificity had little impact on parasite population structure, the habitat preference of the alternate invertebrate host as

  10. Windows 7 resource kit

    CERN Document Server

    Northrup, Tony; Honeycutt, Jerry; Wilson, Ed

    2009-01-01

    In-depth and comprehensive, this RESOURCE KIT delivers the information you need to administer your Windows 7 system. You get authoritative technical guidance from those who know the technology best-Microsoft Most Valuable Professionals (MVPs) and the Windows 7 product team-along with essential scripts and resources. In addition, "Direct from the Source" sidebars offer deep insights and troubleshooting tips from the Windows 7 team. Get expert guidance on how to: Use Microsoft Deployment Toolkit best practices and tools. Plan user-state migration and test application compatibility.

  11. Mobile Probing Kit

    DEFF Research Database (Denmark)

    Larsen, Jakob Eg; Sørensen, Lene Tolstrup; Sørensen, J.K.

    2007-01-01

    Mobile Probing Kit is a low tech and low cost methodology for obtaining inspiration and insights into user needs, requirements and ideas in the early phases of a system's development process. The methodology is developed to identify user needs, requirements and ideas among knowledge workers...... characterized as being highly nomadic and thus potential users of mobile and ubiquitous technologies. The methodology has been applied in the 1ST MAGNET Beyond project in order to obtain user needs and requirements in the process of developing pilot services. We report on the initial findings from applying...

  12. Microgripper construction kit

    Science.gov (United States)

    Gengenbach, Ulrich K.; Hofmann, Andreas; Engelhardt, Friedhelm; Scharnowell, Rudolf; Koehler, Bernd

    2001-10-01

    A large number of microgrippers has been developed in industry and academia. Although the importance of hybrid integration techniques and hence the demand for assembly tools grows continuously a large part of these developments has not yet been used in industrial production. The first grippers developed for microassembly were basically vacuum grippers and downscaled tweezers. Due to increasingly complex assembly tasks more and more functionality such as sensing or additional functions such as adhesive dispensing has been integrated into gripper systems over the last years. Most of these gripper systems are incompatible since there exists no standard interface to the assembly machine and no standard for the internal modules and interfaces. Thus these tools are not easily interchangeable between assembly machines and not easily adaptable to assembly tasks. In order to alleviate this situation a construction kit for modular microgrippers is being developed. It is composed of modules with well defined interfaces that can be combined to build task specific grippers. An abstract model of a microgripper is proposed as a tool to structure the development of the construction kit. The modular concept is illustrated with prototypes.

  13. Thermal dimensioning of the deep repository. Influence of canister spacing, canister power, rock thermal properties and nearfield design on the maximum canister surface temperature

    International Nuclear Information System (INIS)

    Hoekmark, Harald; Faelth, Billy

    2003-12-01

    The report addresses the problem of the minimum spacing required between neighbouring canisters in the deep repository. That spacing is calculated for a number of assumptions regarding the conditions that govern the temperature in the nearfield and at the surfaces of the canisters. The spacing criterion is that the temperature at the canister surfaces must not exceed 100 deg C .The results are given in the form of nomographic charts, such that it is in principle possible to determine the spacing as soon as site data, i.e. the initial undisturbed rock temperature and the host rock heat transport properties, are available. Results of canister spacing calculations are given for the KBS-3V concept as well as for the KBS-3H concept. A combination of numerical and analytical methods is used for the KBS-3H calculations, while the KBS-3V calculations are purely analytical. Both methods are described in detail. Open gaps are assigned equivalent heat conductivities, calculated such that the conduction across the gaps will include also the heat transferred by radiation. The equivalent heat conductivities are based on the emissivities of the different gap surfaces. For the canister copper surface, the emissivity is determined by back-calculation of temperatures measured in the Prototype experiment at Aespoe HRL. The size of the different gaps and the emissivity values are of great importance for the results and will be investigated further in the future

  14. Soil/Rock Properties Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — Soil/Rock Properties LaboratoryLocation: Spokane SiteThe Soil/Rock Properties Laboratory is contained in the soils bay, a 4,700 sq. ft. facility that provides space...

  15. Radiology seminars using teaching kits

    International Nuclear Information System (INIS)

    Munro, T.G.

    1989-01-01

    Clinco-radiological seminars are an effective method of teaching medical students. However, in busy departments it is often difficult to provide enough radiologists for small group instruction. This can be facilitated by the use of prepared teaching kits. Each kit contains a set of duplicated films and a syllabus which gives a short clinical history for each patient and a series of questions to be used to direct the discussion. Each diagnostic problem is chosen to demonstrate core material. We have been using these teaching kits for organ system teaching in the preclerkship year. Teaching kits offer several advantages. They make it easier to recruit seminar leaders through efficient use of their time. The use of duplicated films and a syllabus ensures that all students cover the same material. The syllabus can be used to generate examination questions for reinforcement of important concepts. The kits are also available to students to review alone and can be readily updated as required

  16. Nuclear interactions of cosmic rays with the Mars atmosphere and rocks according to data of the Mars-5 space vehicle

    Energy Technology Data Exchange (ETDEWEB)

    Surkov, Yu A; Moskaleva, L P; Kharyukova, V P; Borodin, A M [AN SSSR, Moscow. Inst. Geokhimii i Analiticheskoj Khimii

    1976-03-01

    Gamma-spectra of Mars have been analyzed measured by the ''Mars-5'' interplanetary station at the altitude of approximately 200 km over the planet. A model spectrum of the Mars atmosphere gamma-radiation obtained earlier has been employed for obtaining cosmo-chemical information of the Mars rocks. In the energy range of gamma radiation Esub(..gamma..)(>=)2.6 MeV, in which no contribution of gamma radiation of natural radioisotopes is present, the best agreement has been obtained for the spectrum of gamma-radiation induced by cosmic rays in rocks of the type of earthly basalts.

  17. Energy Management Curriculum Starter Kit

    Energy Technology Data Exchange (ETDEWEB)

    Turner, W.C.

    1987-02-01

    The Energy Management Curriculum Starter Kit was designed to help engineering educators develop and teach energy management courses. Montana State University and Oklahoma State University courses are embodied in the model curriculum given. The curricula offered at many other universities throughout the United States are also presented. The kit was designed specifically to train engineering students to be good energy managers. Courses at both the undergraduate and postgraduate level are presented.

  18. Rock engineering in Finland

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    Contains a large collection of short articles concerned with tunnels and underground caverns and their construction and use. The articles are grouped under the following headings: use of the subsurface space; water supply; waste water services; energy management (includes articles on power stations, district heating and oil storage and an article on coal storage); multipurpose tunnels; waste disposal; transport; shelters; sporting and recreational amenities located in rock caverns; storage facilities; industrial, laboratory, and service facilities; rock foundations; tourism and culture; utilization of rock masses; research on the disposal of nuclear waste; training and research in the field of rock engineering; site investigation techniques; design of structures in rock; construction; the environment and occupational safety; modern equipment technology; underground space in Helsinki.

  19. Contrasting cultural landscapes and spaces in Peter Weir’s film Picnic at Hanging Rock (1975, based on Joan Lindsay’s 1967 novel with the same title

    Directory of Open Access Journals (Sweden)

    Jytte Holmqvist

    2013-10-01

    Full Text Available The following essay explores the relationship between contrasting cultures and cultural spaces within a rural Australian, Victorian, context, with reference to the narrated cultural landscape in Joan Lindsay’s novel Picnic at Hanging Rock (1967 and in the film based on the novel, by Peter Weir (1975. In the analysis of the five first scenes of the film, the focus will be on the notion of scenic- and human- beauty that is at once arresting and foreboding, and the various contrasting and parallel spaces that characterise the structure of book and film. The article will draw from a number of additional secondary sources, including various cultural readings which offer alternative methodological approaches to the works analysed, and recorded 1970s interviews with the author and the filmmaker.

  20. Pore space quantification of carbonate rocks before-after supercritical CO2 interaction by optical image analysis

    Science.gov (United States)

    Berrezueta, Edgar; José Domínguez-Cuesta, María

    2017-04-01

    The aim of this research is to show an experimental application of an automated quantification process of optical porosity in thin sections. Petrographic studies using scanning electronic microscopy, optical microscopy (OpM) and optical image analysis (OIA) could provide a reproducible pore characterization of carbonate rocks in applications related to the geological storage of CO2. This research is focused on i) the quantification of optical pores in a carbonate rock before and after supercritical CO2-rich brine (P ≈ 7.5 MPa and T ≈ 35 °C) and ii) the description of the process followed to guarantee the reproducibility of the OIA method on images acquired with high-resolution scanner. Mineral images were acquired from thin sections using a high-resolution scanner (HRS). Digital images were geo-referenced by using geographic information system to ensure correct spatial correlation and superposition. The optical measures of porosity by image analysis on the carbonates thin sections showed an effective pore segmentation considering different cross-polarized light conditions (90°/0°; 120°/30°) and plane-polarized light conditions (90°/-) of the same petrographic scene. The pore characterization by OpM and OIA-HRS has allowed a preliminary approximation of pore evolution in carbonate rocks under the supercritical CO2-rich brine. This study shows a fast, effective and reproducible methodology that allowed a preliminary characterization (changes in the pore network) of the samples studied. The procedure carried out could be applied to similar experimental injection tests.

  1. Preparation of albumin radioimmunoassay kit

    International Nuclear Information System (INIS)

    Chen Suoshu; Wang Yanzhen; Wang Zhenshan

    1990-01-01

    This paper presents the preparation of Albumin (Alb) radioimmunoassay kit and its preliminary clinical application. The kit is mainly applied to the measurement of Alb concentration in human urine, adopting second antibody-PEG method. The measurement range is (1-50 μg/ml). The curve obtained with a serially diluted urine sample of high Alb concentration was a straight line. Recovery, detectability, intra- and inter-batch variation coefficients were 95.7%-103.6%, 0.1 μg/ml, 5.8% and 6.4% respectively. The kit was tried out clinically for measuring Alb in urine samples in about 1200 normal individuals and 600 various patients of related renal diseases. The preliminary clinical results show that Alb RIA is conducive to the early diagnosis of kidney function abnormalities

  2. Rock Art

    Science.gov (United States)

    Henn, Cynthia A.

    2004-01-01

    There are many interpretations for the symbols that are seen in rock art, but no decoding key has ever been discovered. This article describes one classroom's experiences with a lesson on rock art--making their rock art and developing their own personal symbols. This lesson allowed for creativity, while giving an opportunity for integration…

  3. Active Parenting Now: Program Kit.

    Science.gov (United States)

    Popkin, Michael H.

    Based largely on the theories of Alfred Adler and Rudolf Dreikurs, this parent education curriculum is a video-based interactive learning experience that teaches a comprehensive model of parenting to parents of children ages 5 to 12 years. The kit provides parents with the skills needed to help their children develop courage, responsibility, and…

  4. Natural Gas Energy Educational Kit.

    Science.gov (United States)

    American Gas Association, Arlington, VA. Educational Services.

    Prepared by energy experts and educators to introduce middle school and high school students to natural gas and its role in our society, this kit is designed to be incorporated into existing science and social studies curricula. The materials and activities focus on the origin, discovery, production, delivery, and use of natural gas. The role of…

  5. Architectural Environment: A Resource Kit.

    Science.gov (United States)

    J.B. Speed Art Museum, Louisville, KY.

    There are many ways to approach the investigation of architecture. One can look at structural form, climate and topography, the aesthetics of style and decoration, building function, historical factors, cultural meanings, or technology and techniques associated with construction. This resource kit touches upon a few of these approaches, ranging…

  6. Work and Family Resource Kit.

    Science.gov (United States)

    Women's Bureau (DOL), Washington, DC.

    This kit is designed to help employers understand the range of family needs emerging in the workplace and the numerous options for a company response. An introduction discusses the need for child care services, dependent care problems, and how employers respond and benefit. Sections address the following: selecting the right option in relation to…

  7. The Impact of Space Flight on Survival and Interaction of Cupriavidus metallidurans CH34 with Basalt, a Volcanic Moon Analog Rock

    Directory of Open Access Journals (Sweden)

    Natalie Leys

    2017-04-01

    Full Text Available Microbe-mineral interactions have become of interest for space exploration as microorganisms could be used to biomine from extra-terrestrial material and extract elements useful as micronutrients in life support systems. This research aimed to identify the impact of space flight on the long-term survival of Cupriavidus metallidurans CH34 in mineral water and the interaction with basalt, a lunar-type rock in preparation for the ESA spaceflight experiment, BIOROCK. Therefore, C. metallidurans CH34 cells were suspended in mineral water supplemented with or without crushed basalt and send for 3 months on board the Russian FOTON-M4 capsule. Long-term storage had a significant impact on cell physiology and energy status (by flow cytometry analysis, plate count and intracellular ATP measurements as 60% of cells stored on ground lost their cell membrane potential, only 17% were still active, average ATP levels per cell were significantly lower and cultivability dropped to 1%. The cells stored in the presence of basalt and exposed to space flight conditions during storage however showed less dramatic changes in physiology, with only 16% of the cells lost their cell membrane potential and 24% were still active, leading to a higher cultivability (50% and indicating a general positive effect of basalt and space flight on survival. Microbe-mineral interactions and biofilm formation was altered by spaceflight as less biofilm was formed on the basalt during flight conditions. Leaching from basalt also changed (measured with ICP-OES, showing that cells release more copper from basalt and the presence of cells also impacted iron and magnesium concentration irrespective of the presence of basalt. The flight conditions thus could counteract some of the detrimental effects observed after the 3 month storage conditions.

  8. Assessment of RFID Read Accuracy for ISS Water Kit

    Science.gov (United States)

    Chu, Andrew

    2011-01-01

    The Space Life Sciences Directorate/Medical Informatics and Health Care Systems Branch (SD4) is assessing the benefits Radio Frequency Identification (RFID) technology for tracking items flown onboard the International Space Station (ISS). As an initial study, the Avionic Systems Division Electromagnetic Systems Branch (EV4) is collaborating with SD4 to affix RFID tags to a water kit supplied by SD4 and studying the read success rate of the tagged items. The tagged water kit inside a Cargo Transfer Bag (CTB) was inventoried using three different RFID technologies, including the Johnson Space Center Building 14 Wireless Habitat Test Bed RFID portal, an RFID hand-held reader being targeted for use on board the ISS, and an RFID enclosure designed and prototyped by EV4.

  9. 'Escher' Rock

    Science.gov (United States)

    2004-01-01

    [figure removed for brevity, see original site] Chemical Changes in 'Endurance' Rocks [figure removed for brevity, see original site] Figure 1 This false-color image taken by NASA's Mars Exploration Rover Opportunity shows a rock dubbed 'Escher' on the southwestern slopes of 'Endurance Crater.' Scientists believe the rock's fractures, which divide the surface into polygons, may have been formed by one of several processes. They may have been caused by the impact that created Endurance Crater, or they might have arisen when water leftover from the rock's formation dried up. A third possibility is that much later, after the rock was formed, and after the crater was created, the rock became wet once again, then dried up and developed cracks. Opportunity has spent the last 14 sols investigating Escher, specifically the target dubbed 'Kirchner,' and other similar rocks with its scientific instruments. This image was taken on sol 208 (Aug. 24, 2004) by the rover's panoramic camera, using the 750-, 530- and 430-nanometer filters. The graph above shows that rocks located deeper into 'Endurance Crater' are chemically altered to a greater degree than rocks located higher up. This chemical alteration is believed to result from exposure to water. Specifically, the graph compares ratios of chemicals between the deep rock dubbed 'Escher,' and the more shallow rock called 'Virginia,' before (red and blue lines) and after (green line) the Mars Exploration Rover Opportunity drilled into the rocks. As the red and blue lines indicate, Escher's levels of chlorine relative to Virginia's went up, and sulfur down, before the rover dug a hole into the rocks. This implies that the surface of Escher has been chemically altered to a greater extent than the surface of Virginia. Scientists are still investigating the role water played in influencing this trend. These data were taken by the rover's alpha particle X-ray spectrometer.

  10. Respiratory motion-resolved, self-gated 4D-MRI using Rotating Cartesian K-space (ROCK): Initial clinical experience on an MRI-guided radiotherapy system.

    Science.gov (United States)

    Han, Fei; Zhou, Ziwu; Du, Dongsu; Gao, Yu; Rashid, Shams; Cao, Minsong; Shaverdian, Narek; Hegde, John V; Steinberg, Michael; Lee, Percy; Raldow, Ann; Low, Daniel A; Sheng, Ke; Yang, Yingli; Hu, Peng

    2018-06-01

    To optimize and evaluate the respiratory motion-resolved, self-gated 4D-MRI using Rotating Cartesian K-space (ROCK-4D-MRI) method in a 0.35 T MRI-guided radiotherapy (MRgRT) system. The study included seven patients with abdominal tumors treated on the MRgRT system. ROCK-4D-MRI and 2D-CINE, was performed immediately after one of the treatment fractions. Motion quantification based on 4D-MRI was compared with those based on 2D-CINE. The image quality of 4D-MRI was evaluated against 4D-CT. The gross tumor volumes (GTV) were defined based on individual respiratory phases of both 4D-MRI and 4D-CT and compared for their variability over the respiratory cycle. The motion measurements based on 4D-MRI matched well with 2D-CINE, with differences of 1.04 ± 0.52 mm in the superior-inferior and 0.54 ± 0.21 mm in the anterior-posterior directions. The image quality scores of 4D-MRI were significantly higher than 4D-CT, with better tumor contrast (3.29 ± 0.76 vs. 1.86 ± 0.90) and less motion artifacts (3.57 ± 0.53 vs. 2.29 ± 0.95). The GTVs were more consistent in 4D-MRI than in 4D-CT, with significantly smaller GTV variability (9.31 ± 4.58% vs. 34.27 ± 23.33%). Our study demonstrated the clinical feasibility of using the ROCK-4D-MRI to acquire high quality, respiratory motion-resolved 4D-MRI in a low-field MRgRT system. The 4D-MRI image could provide accurate dynamic information for radiotherapy treatment planning. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. Rock glaciers, Central Andes, Argentina, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — Primary rock glaciers are fed by avalanche chutes. At the El Salto rock glacier, surveys have been undertaken in order to determine the creep rate. Between 1981 and...

  12. CERN’s FMC Kit

    CERN Document Server

    Cattin, M; Serrano, J; van der Bij, E; Wlostowski, T

    2014-01-01

    In the context of the renovation of controls and data acquisition electronics for accelerators the BE-CO-HT section at CERN has designed a kit based on carriers and mezzanines following the VITA FPGAMezzanine Card (FMC) standard. Carriers exist in VME64x and PCIe form factors, with a PXIe carrier underway. Mezzanines include an Analog to Digital Converter, a Time to Digital Converter, a fine delay generator and a Digital Input/Output. All of the designs are licensed under the CERN Open Hardware Licence and commercialised by companies. This paper discusses the benefits of this carrier mezzanine strategy and of the Open Hardware based commercial paradigm. It also explains the design of each layer of the FMC kit, from the hardware to the gateware and the Linux device driver. In addition, several tools to help designers developing gateware for mezzanines and new concepts such as the Self-Describing Bus (SDB) and the fmcbus are presented. Lastly, some of the plans for the future of the FMC kit and Open Hardware Re...

  13. Recreating Rocks

    DEFF Research Database (Denmark)

    Posth, Nicole R

    2008-01-01

    Nicole Posth and colleagues spent a month touring South African rock formations in their quest to understand the origin of ancient iron and silicate layers.......Nicole Posth and colleagues spent a month touring South African rock formations in their quest to understand the origin of ancient iron and silicate layers....

  14. Molecular Alterations of KIT Oncogene in Gliomas

    Directory of Open Access Journals (Sweden)

    Ana L. Gomes

    2007-01-01

    Full Text Available Gliomas are the most common and devastating primary brain tumours. Despite therapeutic advances, the majority of gliomas do not respond either to chemo or radiotherapy. KIT, a class III receptor tyrosine kinase (RTK, is frequently involved in tumourigenic processes. Currently, KIT constitutes an attractive therapeutic target. In the present study we assessed the frequency of KIT overexpression in gliomas and investigated the genetic mechanisms underlying KIT overexpression. KIT (CD117 immunohistochemistry was performed in a series of 179 gliomas of various grades. KIT activating gene mutations (exons 9, 11, 13 and 17 and gene amplification analysis, as defined by chromogenic in situ hybridization (CISH and quantitative real-time PCR (qRT-PCR were performed in CD117 positive cases. Tumour cell immunopositivity was detected in 15.6% (28/179 of cases, namely in 25% (1/4 of pilocytic astrocytomas, 25% (5/20 of diffuse astrocytomas, 20% (1/5 of anaplastic astrocytomas, 19.5% (15/77 of glioblastomas and one third (3/9 of anaplastic oligoastrocytomas. Only 5.7% (2/35 of anaplastic oligodendrogliomas showed CD117 immunoreactivity. No association was found between tumour CD117 overexpression and patient survival. In addition, we also observed CD117 overexpression in endothelial cells, which varied from 0–22.2% of cases, being more frequent in high-grade lesions. No KIT activating mutations were identified. Interestingly, CISH and/or qRT-PCR analysis revealed the presence of KIT gene amplification in 6 glioblastomas and 2 anaplastic oligoastrocytomas, corresponding to 33% (8/24 of CD117 positive cases. In conclusion, our results demonstrate that KIT gene amplification rather than gene mutation is a common genetic mechanism underlying KIT expression in subset of malignant gliomas. Further studies are warranted to determine whether glioma patients exhibiting KIT overexpression and KIT gene amplification may benefit from therapy with anti-KIT RTK

  15. Art Rocks with Rock Art!

    Science.gov (United States)

    Bickett, Marianne

    2011-01-01

    This article discusses rock art which was the very first "art." Rock art, such as the images created on the stone surfaces of the caves of Lascaux and Altimira, is the true origin of the canvas, paintbrush, and painting media. For there, within caverns deep in the earth, the first artists mixed animal fat, urine, and saliva with powdered minerals…

  16. Weathering of rock 'Ginger'

    Science.gov (United States)

    1997-01-01

    One of the more unusual rocks at the site is Ginger, located southeast of the lander. Parts of it have the reddest color of any material in view, whereas its rounded lobes are gray and relatively unweathered. These color differences are brought out in the inset, enhanced at the upper right. In the false color image at the lower right, the shape of the visible-wavelength spectrum (related to the abundance of weathered ferric iron minerals) is indicated by the hue of the rocks. Blue indicates relatively unweathered rocks. Typical soils and drift, which are heavily weathered, are shown in green and flesh tones. The very red color in the creases in the rock surface correspond to a crust of ferric minerals. The origin of the rock is uncertain; the ferric crust may have grown underneath the rock, or it may cement pebbles together into a conglomerate. Ginger will be a target of future super-resolution studies to better constrain its origin.Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator. JPL is an operating division of the California Institute of Technology (Caltech).

  17. Rock Physics

    DEFF Research Database (Denmark)

    Fabricius, Ida Lykke

    2017-01-01

    Rock physics is the discipline linking petrophysical properties as derived from borehole data to surface based geophysical exploration data. It can involve interpretation of both elastic wave propagation and electrical conductivity, but in this chapter focus is on elasticity. Rock physics is based...... on continuum mechanics, and the theory of elasticity developed for statics becomes the key to petrophysical interpretation of velocity of elastic waves. In practice, rock physics involves interpretation of well logs including vertical seismic profiling (VSP) and analysis of core samples. The results...

  18. Kit with track detectors aiming at didactic

    International Nuclear Information System (INIS)

    Cesar, M.F.; Koskinas, M.F.

    1988-01-01

    The kit intends to improve the possibilities in performing experiments of Nuclear Physics in Modern Physics Laboratories of Physics Course introducing the solid state nuclear track detectors. In these materials the passage of heavily ionizing nuclear particles creates paths (tracks) that may be revealed and made visible in an optical microscope. By the help of the kit several experiments and/or demonstrations may be performed. The kit contains solid state nuclear track detectors unirradiated and irradiated, irradiated etched and uneteched sheets; an alpha source of 241 Am and an instrution text with photomicrographs. To use the kit the laboratory must have an ordinary optical microscope. (author) [pt

  19. Rock engineering applications, 1991

    International Nuclear Information System (INIS)

    Franklin, J.A.; Dusseault, M.B.

    1991-01-01

    This book demonstrates how to apply the theories and principles of rock engineering to actual engineering and construction tasks. It features insights on geology for mining and tunnelling applications. It is practical resource that focuses on the latest technological innovation and examines up-to-date procedures used by engineers for coping with complex rock conditions. The authors also discuss question related to underground space, from design approaches to underground housing and storage. And they cover the monitoring of storage caverns for liquid and gaseous products or toxic and radioactive wastes

  20. Rocking pneumonia

    OpenAIRE

    Rijkers, Ger T.; Rodriguez Gomez, Maria

    2017-01-01

    Ever since Chuck Berry coined the term “rocking pneumonia” in his 1956 song “Roll over Beethoven”, pneumonia has been mentioned frequently in modern blues and rock songs. We analyzed the lyrics of these songs to examine how various elements of pneumonia have been represented in popular music, specifically the cause of pneumonia, the risk groups, comorbidity (such as the boogie woogie flu), the clinical symptoms, and treatment and outcome. Up to this day, songwriters suggest that pneumonia is ...

  1. Preparation of kits for 99Tcm radiopharmaceuticals

    International Nuclear Information System (INIS)

    1992-05-01

    This publication details preparation under Good Manufacturing Practices (GMP) of thirteen widely used 99 Tc m radiopharmaceuticals and their quality assurance practices. The objective of this document is to present to those who intend to launch a kit preparation programme a set of preparation procedures and other relevant information gathered during kit production over a period of more than a decade, to serve as a good starting point. The manuals and monographs included in the document are based on the experience gained in two major centres. The publication of this material is intended to give a typical example, and not the only possible procedure for preparing the kits. Following the essentials of these kit preparation procedures, it is always possible to make alterations to the composition of the kits. The kits described here concern widely used 99 Tc m radiopharmaceuticals which do not require a Single Photon Emission Computed Tomography (SPECT) camera. These examples of the ''first generation'' of kits are not very intricate to prepare. Although it is advisable to have only one agent for a given intended use, a few agents for each purpose, e.g. EHDP and MDP for bone imagining, have been included in the document so that the reader can have some flexibility in selecting a particular kit. 24 refs, 2 figs

  2. A fiber-optic polarimetric demonstration kit

    International Nuclear Information System (INIS)

    Eftimov, T; Dimitrova, T L; Ivanov, G

    2012-01-01

    A simple and multifunctional fiber-optic polarimetric kit on the basis of highly birefringent single-mode fibers is presented. The fiber-optic polarimetric kit allows us to perform the following laboratory exercises: (i) fiber excitation and the measurement of numerical aperture, (ii) polarization preservation and (iii) obtain polarization-sensitive fiberized interferometers.

  3. Building Use Policies. SPEC Kit 144.

    Science.gov (United States)

    Coyle, Patrick

    This Systems and Procedures Exchange Center (SPEC) flyer/kit addresses some of the needs of Association of Research Libraries (ARL) members regarding library building use and the aesthetics and well-being of the materials and people in the building. The kit draws upon documents gathered as part of a 1986 Quick-SPEC survey that dealt with food and…

  4. Teen Ambassador Leadership Kit (TALK

    Directory of Open Access Journals (Sweden)

    Donna R. Gillespie

    2012-12-01

    Full Text Available Teen Ambassador Leadership Kit, (TALK, is an annual weekend retreat designed for teens interested in promoting and marketing 4-H in their communities. TALK organizers felt teens would benefit from an intensive weekend retreat focused on communication. TALK produces a network of educated and excited 4-H teens that are available to help with 4-H promotion and marketing. Participants arrive on Friday evening for team building activities, on Saturday they participate in one of the workshops offered and on Sunday morning each workshop group has the opportunity to share their completed projects and what they learned. At the conclusion of the retreat, teens are designated "County 4-H Ambassadors" and certificates of completion, professional business cards and polo shirts are presented. The TALK teen participants return home to share what they learned with their local county 4-H staff and help promote and market 4-H in their communities.

  5. Personal radiotoxicological (first aid) kit

    International Nuclear Information System (INIS)

    Gachalyi, Andras; Gyulai, Gabor

    2014-01-01

    In recent years, with the spread of nuclear industrial activities, and the widespread use of radioactive materials and products the possibility of radionuclide contamination of humans and animals has significantly increased. During nuclear tests or reactor accidents, a large amount of radioactive materials may enter the environment which can contaminate the living environment (air, water, vegetation, soil), for a long period. This contamination may enter living organisms by inhalation, intake and ingestion, causing severe biological damage. As an example the Chernobyl reactor accident can be mentioned, where there was no possibility for the decorporation of isotopes, as there were no products available such as the 'RADISTOP'. To achieve appropriate decorporating (and decontaminating) treatment which is effective, it is highly recommendable to use a personal Radiotoxicological First Aid Kit (PRK) within the shortest possible time after internal contamination. This unit provides effective treatment to decorporate the most common incorporated fission products. (author)

  6. Source rock

    Directory of Open Access Journals (Sweden)

    Abubakr F. Makky

    2014-03-01

    Full Text Available West Beni Suef Concession is located at the western part of Beni Suef Basin which is a relatively under-explored basin and lies about 150 km south of Cairo. The major goal of this study is to evaluate the source rock by using different techniques as Rock-Eval pyrolysis, Vitrinite reflectance (%Ro, and well log data of some Cretaceous sequences including Abu Roash (E, F and G members, Kharita and Betty formations. The BasinMod 1D program is used in this study to construct the burial history and calculate the levels of thermal maturity of the Fayoum-1X well based on calibration of measured %Ro and Tmax against calculated %Ro model. The calculated Total Organic Carbon (TOC content from well log data compared with the measured TOC from the Rock-Eval pyrolysis in Fayoum-1X well is shown to match against the shale source rock but gives high values against the limestone source rock. For that, a new model is derived from well log data to calculate accurately the TOC content against the limestone source rock in the study area. The organic matter existing in Abu Roash (F member is fair to excellent and capable of generating a significant amount of hydrocarbons (oil prone produced from (mixed type I/II kerogen. The generation potential of kerogen in Abu Roash (E and G members and Betty formations is ranging from poor to fair, and generating hydrocarbons of oil and gas prone (mixed type II/III kerogen. Eventually, kerogen (type III of Kharita Formation has poor to very good generation potential and mainly produces gas. Thermal maturation of the measured %Ro, calculated %Ro model, Tmax and Production index (PI indicates that Abu Roash (F member exciting in the onset of oil generation, whereas Abu Roash (E and G members, Kharita and Betty formations entered the peak of oil generation.

  7. KIT safety management. Annual report 2012

    International Nuclear Information System (INIS)

    Frank, Gerhard

    2013-01-01

    The KIT Safety Management Service Unit (KSM) guarantees radiological and conventional technical safety and security of Karlsruhe Institute of Technology and controls the implementation and observation of legal environmental protection requirements. KSM is responsible for - licensing procedures, - industrial safety organization, - control of environmental protection measures, - planning and implementation of emergency preparedness and response, - operation of radiological laboratories and measurement stations, - extensive radiation protection support and the - the execution of security tasks in and for all organizational units of KIT. Moreover, KSM is in charge of wastewater and environmental monitoring for all facilities and nuclear installations all over the KIT campus. KSM is headed by the Safety Commissioner of KIT, who is appointed by the Presidential Committee. Within his scope of procedure for KIT, the Safety Commissioner controls the implementation of and compliance with safety-relevant requirements. The KIT Safety Management is certified according to DIN EN ISO 9001, its industrial safety management is certified by the VBG as ''AMS-Arbeitsschutz mit System'' and, hence, fulfills the requirements of NLF / ISO-OSH 2001. KSM laboratories are accredited according to DIN EN ISO/IEC 17025. To the extent possible, KSM is committed to maintaining competence in radiation protection and to supporting research and teaching activities. The present reports lists the individual tasks of the KIT Safety Management and informs about the results achieved in 2012. Status figures in principle reflect the status at the end of the year 2012. The processes described cover the areas of competence of KSM.

  8. Intellektuaalne rock

    Index Scriptorium Estoniae

    2007-01-01

    Briti laulja-helilooja ja näitleja Toyah Willcox ning Bill Rieflin ansamblist R.E.M. ja Pat Mastelotto King Krimsonist esinevad koos ansamblitega The Humans ja Tuner 25. okt. Tallinnas Rock Cafés ja 27. okt Tartu Jaani kirikus

  9. Estradiol RIA kit in clinical practice

    International Nuclear Information System (INIS)

    Friedrich, W.; Lisse, K.; Bienert, R.; Flentje, H.; Koerner, H.; Wilken, T.; Akademie der Wissenschaften der DDR, Berlin-Buch. Zentralinstitut fuer Isotopen- und Strahlenforschung)

    1985-01-01

    First clinical experience with a estradiol RIA kit developed in the Central Institute for Isotope- and Radiation Research is reported. The kit was used for the daily control of estradiol level in patients, which were treated within the program for in vitro fertilization and embryo transfer. The time of incubation could be shortened by means of a double antibody technique and by use of a precipitation mixture to 2 h. The intraassay variation is 9.2%, the interassay variation is 15.1%, the recovery rate is 94%. The sensitivity of the test (B 0 -3SD) is about 120 pmol/l. The estradiol RIA kit satisfies clinical requirements. (author)

  10. Igneous Rocks

    Science.gov (United States)

    Doe, Bruce R.

    “Igneous Rocks was written for undergraduate geology majors who have had a year of college-level chemistry and a course in mineralogy … and for beginning graduate students. Geologists working in industry, government, or academia should find this text useful as a guide to the technical literature up to 1981 and as an overview of topics with which they have not worked but which may have unanticipated pertinence to their own projects.” So starts the preface to this textbook.As one who works part time in research on igneous rocks, especially as they relate to mineral deposits, I have been looking for such a book with this avowed purpose in a field that has a choking richness of evolving terminology and a bewildering volume of interdisciplinary literature. In addition to the standard topics of igneous petrology, the book contains a chapter on the role of igneous activity in the genesis of mineral deposits, its value to geothermal energy, and the potential of igneous rocks as an environment for nuclear waste disposal. These topics are presented rather apologetically in the preface, but the author is to be applauded for including this chapter. The apology shows just how new these interests are to petrology. Recognition is finally coming that, for example, mineral deposits are not “sports of nature,” a view held even by many economic geologists as recently as the early 1960's; instead they are perfectly ordinary geochemical features formed by perfectly ordinary geologic processes. In fact, the mineral deposits and their attendant alteration zones probably have as much to tell us about igneous rocks as the igneous rocks have to tell us about mineral deposits.

  11. Analysis of KIT expression and KIT exon 11 mutations in canine oral malignant melanomas.

    Science.gov (United States)

    Murakami, A; Mori, T; Sakai, H; Murakami, M; Yanai, T; Hoshino, Y; Maruo, K

    2011-09-01

    KIT, a transmembrane receptor tyrosine kinase, is one of the specific targets for anti-cancer therapy. In humans, its expression and mutations have been identified in malignant melanomas and therapies using molecular-targeted agents have been promising in these tumours. As human malignant melanoma, canine malignant melanoma is a fatal disease with metastases and the poor response has been observed with all standard protocols. In our study, KIT expression and exon 11 mutations in dogs with histologically confirmed malignant oral melanomas were evaluated. Although 20 of 39 cases were positive for KIT protein, there was no significant difference between KIT expression and overall survival. Moreover, polymerase chain reaction amplification and sequencing of KIT exon 11 in 17 samples did not detect any mutations and proved disappointing. For several reasons, however, KIT expression and mutations of various exons including exon 11 should be investigated in more cases. © 2011 Blackwell Publishing Ltd.

  12. Multicentre evaluation of commercial kit methods

    DEFF Research Database (Denmark)

    Gram, J; Declerck, P J; Sidelmann, Johannes Jakobsen

    1993-01-01

    In order to study the analytical performance of different commercial kits for determination of plasminogen activator inhibitor (PAI) activity we distributed eight selected split samples to 11 European laboratories experienced with haemostasis testing. Three different laboratories were involved in...... of the plasma samples, which was PAI-1 depleted. The laboratories involved in the testing reported for this sample a mean value of 6.1 IU/ml.(ABSTRACT TRUNCATED AT 250 WORDS)......In order to study the analytical performance of different commercial kits for determination of plasminogen activator inhibitor (PAI) activity we distributed eight selected split samples to 11 European laboratories experienced with haemostasis testing. Three different laboratories were involved...... in the production of data from each of the commercial kits tested. A considerable variation of PAI activity results reported from the laboratories testing the same commercial kits was observed. The range of reported results could in individual samples exceed the median value indicating an interlaboratory variation...

  13. Explanatory chapter: how plasmid preparation kits work.

    Science.gov (United States)

    Koontz, Laura

    2013-01-01

    To isolate plasmid DNA from bacteria using a commercial plasmid miniprep kit (if interested, compare this protocol with Isolation of plasmid DNA from bacteria). Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Production of sestamibi kit for nuclear imaging

    Energy Technology Data Exchange (ETDEWEB)

    Abdullah, Hakim; Zakaria, Ahmad; Yaacob, Hadzri; Ramli, Jamaluddin [Universiti Sains Malaysia, Kelantan (Malaysia). School of Medical Sciences

    1997-12-01

    One of the research projects undertaken during the implementation of the IAEA Technical Assistance Cooperation Program in our department was inhouse production of sestamibi (MIBI) kit to be labelled with Tc99m pertechnetate for myocardial studies and for malignant tumor imaging. 100 mg raw materials of sestamibi was supplied by IAEA and the kit was prepared based on Janoki recipe. Using 6 mg MIBI, 192 mg glycine, 3.6 mg stannous chloride, 62.4 mg Na sub 4 Po sub 4 and 24 mg cysteine we have prepared 24 vials of MIBI kit under sterile condition and stored in the freezer at -70 degree C. The sterility of the kit was confirmed by microbiological test using cultured method. The stability test was done by labelling the kit with Tc-99m pertechnetate at day 1, 3, 7, 30 and 60 days after kit preparation. Using two system butanone and saline with ITLC the labelling efficiency of Tc-99m (MIBI) was found to be more than 90% in each case. The labelling efficiency was found to maintain at 90% up to 24 hours post reconstitution at room temperature. Biodistribution study was carried out by administering Tc-99m (MIBI) to mice intravenously at the dosage of IOO {mu} Ci per 20 gm body weight. The mice were sacrificed at 3 hours and 24 hours after the dose administration. Blood, heart, lung, intestine, kidney and stomach samples were obtained, weighed and measured for radioactivity using gamma well counter. The data showed that after 3 hours about 60% of the injected dose accumulated in the intestine which was in agreement with IAEA standard. At 24 hours the amount in the heart still remained about 25% of the 3 hour uptake. In house production of MIBI kit is easy, fast and cost effective. The data suggested that the quality of our kit was good enough to be used for further animal research and clinical trials.

  15. White Rock

    Science.gov (United States)

    2002-01-01

    (Released 19 April 2002) The Science 'White Rock' is the unofficial name for this unusual landform which was first observed during the Mariner 9 mission in the early 1970's. As later analysis of additional data sets would show, White Rock is neither white nor dense rock. Its apparent brightness arises from the fact that the material surrounding it is so dark. Images from the Mars Global Surveyor MOC camera revealed dark sand dunes surrounding White Rock and on the floor of the troughs within it. Some of these dunes are just apparent in the THEMIS image. Although there was speculation that the material composing White Rock could be salts from an ancient dry lakebed, spectral data from the MGS TES instrument did not support this claim. Instead, the White Rock deposit may be the erosional remnant of a previously more continuous occurrence of air fall sediments, either volcanic ash or windblown dust. The THEMIS image offers new evidence for the idea that the original deposit covered a larger area. Approximately 10 kilometers to the southeast of the main deposit are some tiny knobs of similarly bright material preserved on the floor of a small crater. Given that the eolian erosion of the main White Rock deposit has produced isolated knobs at its edges, it is reasonable to suspect that the more distant outliers are the remnants of a once continuous deposit that stretched at least to this location. The fact that so little remains of the larger deposit suggests that the material is very easily eroded and simply blows away. The Story Fingers of hard, white rock seem to jut out like icy daggers across a moody Martian surface, but appearances can be deceiving. These bright, jagged features are neither white, nor icy, nor even hard and rocky! So what are they, and why are they so different from the surrounding terrain? Scientists know that you can't always trust what your eyes see alone. You have to use other kinds of science instruments to measure things that our eyes can

  16. 46 CFR 184.710 - First-aid kits.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false First-aid kits. 184.710 Section 184.710 Shipping COAST... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Miscellaneous § 184.710 First-aid kits. A vessel must carry either a first-aid kit approved under approval series 160.041 or a kit with equivalent contents...

  17. 21 CFR 868.1100 - Arterial blood sampling kit.

    Science.gov (United States)

    2010-04-01

    ...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Diagnostic Devices § 868.1100 Arterial blood sampling kit. (a) Identification. An arterial blood sampling kit is a device, in kit form, used to obtain arterial blood samples... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Arterial blood sampling kit. 868.1100 Section 868...

  18. Quality control of radioimmunoassay kits of pituitary hormones

    International Nuclear Information System (INIS)

    Caso Pena, R.; Arranz Calzado, C.

    1997-01-01

    The present work describe the quality control procedures carried out on three RIA-Kits by the Isotopes Centre of Cuba, The subject matter of study were ;: were: LH-RIA-Kit, FSH-RIA-Kit and Prolactin- RIA -Kit. The controls have included the characterization of the 125 I labelled hormones the specific antibodies, the 2 nd antibodies, the standards curves and the control serum. For the validation of these Kits were used reference standards from the WHO (World Health Organizations) and Kits from CIS company (France) based on the IRMA assays technologies . The results obtained allow us encourage the reliability of RIA-Kits

  19. Role of ELA region in auto-activation of mutant KIT receptor: a molecular dynamics simulation insight.

    Science.gov (United States)

    Purohit, Rituraj

    2014-01-01

    KIT receptor is the prime target in gastrointestinal stromal tumor (GISTs) therapy. Second generation inhibitor, Sunitinib, binds to an inactivated conformation of KIT receptor and stabilizes it in order to prevent tumor formation. Here, we investigated the dynamic behavior of wild type and mutant D816H KIT receptor, and emphasized the extended A-loop (EAL) region (805-850) by conducting molecular dynamics simulation (∼100 ns). We analyzed different properties such as root mean square cutoff or deviation, root mean square fluctuation, radius of gyration, solvent-accessible surface area, hydrogen bonding network analysis, and essential dynamics. Apart from this, clustering and cross-correlation matrix approach was used to explore the conformational space of the wild type and mutant EAL region of KIT receptor. Molecular dynamics analysis indicated that mutation (D816H) was able to alter intramolecular hydrogen bonding pattern and affected the structural flexibility of EAL region. Moreover, flexible secondary elements, specially, coil and turns were dominated in EAL region of mutant KIT receptor during simulation. This phenomenon increased the movement of EAL region which in turn helped in shifting the equilibrium towards the active kinase conformation. Our atomic investigation of mutant KIT receptor which emphasized on EAL region provided a better insight into the understanding of Sunitinib resistance mechanism of KIT receptor and would help to discover new therapeutics for KIT-based resistant tumor cells in GIST therapy.

  20. Rock stresses (Grimsel rock laboratory)

    International Nuclear Information System (INIS)

    Pahl, A.; Heusermann, S.; Braeuer, V.; Gloeggler, W.

    1989-01-01

    On the research and development project 'Rock Stress Measurements' the BGR has developed and tested several test devices and methods at GTS for use in boreholes at a depth of 200 m and has carried out rock mechanical and engineering geological investigations for the evaluation and interpretation of the stress measurements. The first time a computer for data processing was installed in the borehole together with the BGR-probe. Laboratory tests on hollow cylinders were made to study the stress-deformation behavior. To validate and to interprete the measurement results some test methods were modelled using the finite-element method. The dilatometer-tests yielded high values of Young's modulus, whereas laboratory tests showed lower values with a distinct deformation anisotropy. Stress measurements with the BGR-probe yielded horizontal stresses being higher than the theoretical overburden pressure and vertical stresses which agree well with the theoretical overburden pressure. These results are comparable to the results of the hydraulic fracturing tests, whereas stresses obtained with CSIR-triaxial cells are generally lower. The detailed geological mapping of the borehole indicated relationships between stress and geology. With regard to borehole depth different zones of rock structure joint frequency, joint orientation, and orientation of microfissures as well as stress magnitude, stress direction, and degree of deformation anisotropy could be distinguished. (orig./HP) [de

  1. Quality control of radioimmunoassay kits of pituitary hormones; Control de calidad de kits de radioinmunoanalisis de hormonas hipofisiarias

    Energy Technology Data Exchange (ETDEWEB)

    Caso Pena, R [Centro de Isotopos, La Habana (Cuba); Arranz Calzado, C [Instituto Nacional de Endocrinologia, La Habana (Cuba)

    1998-12-31

    The present work describe the quality control procedures carried out on three RIA-Kits by the Isotopes Centre of Cuba, The subject matter of study were ;: were: LH-RIA-Kit, FSH-RIA-Kit and Prolactin- RIA -Kit. The controls have included the characterization of the {sup 125}I labelled hormones the specific antibodies, the 2 nd antibodies, the standards curves and the control serum. For the validation of these Kits were used reference standards from the WHO (World Health Organizations) and Kits from CIS company (France) based on the IRMA assays technologies . The results obtained allow us encourage the reliability of RIA-Kits

  2. Thermal Inertia of Rocks and Rock Populations

    Science.gov (United States)

    Golombek, M. P.; Jakosky, B. M.; Mellon, M. T.

    2001-01-01

    The effective thermal inertia of rock populations on Mars and Earth is derived from a model of effective inertia versus rock diameter. Results allow a parameterization of the effective rock inertia versus rock abundance and bulk and fine component inertia. Additional information is contained in the original extended abstract.

  3. The Fluid Dynamics Demo Kit: Part I

    Science.gov (United States)

    Flack, Karen; Underhill, Patrick; Prestridge, Kathy

    2012-11-01

    The goal of this project is to develop a fluid dynamics demonstration/experiment kit that can be used by professors and graduate students at high school outreach events. The demonstrations in the kit will be easy to use and true crowd pleasers in order to inspire understanding and pique curiosity about the physics of flow. The kits will be inexpensive, containing readily available materials so that teachers can duplicate the demonstrations and experiments. The kits will be left with the teachers as a gift from the American Physics Society. The experiments and demonstrations cover the concepts of conservation of mass, momentum, and energy, Bernoulli's equation, frictional losses and the ideal gas law. For each experiment, the teachers will receive presentation material, access to instructional videos, plus a worksheet that can be used in a high school physics classroom. This kit has been developed through the efforts of the APS-DFD Mentoring and Outreach Committee and has received funding from the APS-DFD. Work funded by the APS-DFD.

  4. Rock glaciers on South Shetland Islands, Antarctic Peninsula, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — In the South Shetland Islands the investigators found eight active rock glaciers, no relict or fossil examples, and seven protalus ramparts. The rock glaciers are...

  5. Rock glaciers in the Pyrenees, Spain and France, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — This study and inventory of active rock glaciers was carried out by means of the usual techniques used in the study of alpine permafrost. First, the rock glaciers...

  6. Water - rock interaction in different rock environments

    International Nuclear Information System (INIS)

    Lamminen, S.

    1995-01-01

    The study assesses the groundwater geochemistry and geological environment of 44 study sites for radioactive waste disposal. Initially, the study sites were divided by rock type into 5 groups: (1) acid - intermediate rocks, (2) mafic - ultramafic rocks, (3) gabbros, amphibolites and gneisses that contain calc-silicate (skarn) rocks, (4) carbonates and (5) sandstones. Separate assessments are made of acid - intermediate plutonic rocks and of a subgroup that comprises migmatites, granite and mica gneiss. These all belong to the group of acid - intermediate rocks. Within the mafic -ultramafic rock group, a subgroup that comprises mafic - ultramafic plutonic rocks, serpentinites, mafic - ultramafic volcanic rocks and volcanic - sedimentary schists is also evaluated separately. Bedrock groundwaters are classified by their concentration of total dissolved solids as fresh, brackish, saline, strongly saline and brine-class groundwaters. (75 refs., 24 figs., 3 tabs.)

  7. Tool Kit Helps Digitize Tide Gauge Records

    Science.gov (United States)

    Ullmann, Albin; Pons, Frédéric; Moron, Vincent

    2005-09-01

    The Numérisation des Niveaux d'Eau (NUNIEAU) is an integrated and automated MATLAB computer program tool kit for digitizing, transforming, and validating paper records of sea level variations, called marigrams (Figure 1a), that can cut in half the time required to digitize paper records. This tool kit developed in 2004 by F. Pons is currently obtainable by request from the developer, but will be available online on the IMPLIT (Impact des événements extremes sur les hydro-systèmes du litoral méditerranéen français) Web site in early 2006.

  8. KIT safety management. Annual report 2012; KIT-Sicherheitsmanagement. Jahresbericht 2012

    Energy Technology Data Exchange (ETDEWEB)

    Frank, Gerhard (ed.)

    2013-07-01

    The KIT Safety Management Service Unit (KSM) guarantees radiological and conventional technical safety and security of Karlsruhe Institute of Technology and controls the implementation and observation of legal environmental protection requirements. KSM is responsible for - licensing procedures, - industrial safety organization, - control of environmental protection measures, - planning and implementation of emergency preparedness and response, - operation of radiological laboratories and measurement stations, - extensive radiation protection support and the - the execution of security tasks in and for all organizational units of KIT. Moreover, KSM is in charge of wastewater and environmental monitoring for all facilities and nuclear installations all over the KIT campus. KSM is headed by the Safety Commissioner of KIT, who is appointed by the Presidential Committee. Within his scope of procedure for KIT, the Safety Commissioner controls the implementation of and compliance with safety-relevant requirements. The KIT Safety Management is certified according to DIN EN ISO 9001, its industrial safety management is certified by the VBG as ''AMS-Arbeitsschutz mit System'' and, hence, fulfills the requirements of NLF / ISO-OSH 2001. KSM laboratories are accredited according to DIN EN ISO/IEC 17025. To the extent possible, KSM is committed to maintaining competence in radiation protection and to supporting research and teaching activities. The present reports lists the individual tasks of the KIT Safety Management and informs about the results achieved in 2012. Status figures in principle reflect the status at the end of the year 2012. The processes described cover the areas of competence of KSM.

  9. FUELS IN SOIL TEST KIT: FIELD USE OF DIESEL DOG SOIL TEST KITS

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2001-05-31

    Western Research Institute (WRI) is commercializing Diesel Dog Portable Soil Test Kits for performing analysis of fuel-contaminated soils in the field. The technology consists of a method developed by WRI (U.S. Patents 5,561,065 and 5,976,883) and hardware developed by WRI that allows the method to be performed in the field (patent pending). The method is very simple and does not require the use of highly toxic reagents. The aromatic components in a soil extract are measured by absorption at 254 nm with a field-portable photometer. WRI added significant value to the technology by taking the method through the American Society for Testing and Materials (ASTM) approval and validation processes. The method is designated ASTM Method D-5831-96, Standard Test Method for Screening Fuels in Soils. This ASTM designation allows the method to be used for federal compliance activities. In FY 99, twenty-five preproduction kits were successfully constructed in cooperation with CF Electronics, Inc., of Laramie, Wyoming. The kit components work well and the kits are fully operational. In the calendar year 2000, kits were provided to the following entities who agreed to participate as FY 99 and FY 00 JSR (Jointly Sponsored Research) cosponsors and use the kits as opportunities arose for field site work: Wyoming Department of Environmental Quality (DEQ) (3 units), F.E. Warren Air Force Base, Gradient Corporation, The Johnson Company (2 units), IT Corporation (2 units), TRC Environmental Corporation, Stone Environmental, ENSR, Action Environmental, Laco Associates, Barenco, Brown and Caldwell, Dames and Moore Lebron LLP, Phillips Petroleum, GeoSyntek, and the State of New Mexico. By early 2001, ten kits had been returned to WRI following the six-month evaluation period. On return, the components of all ten kits were fully functional. The kits were upgraded with circuit modifications, new polyethylene foam inserts, and updated instruction manuals.

  10. Megakaryocytes compensate for Kit insufficiency in murine arthritis.

    Science.gov (United States)

    Cunin, Pierre; Penke, Loka R; Thon, Jonathan N; Monach, Paul A; Jones, Tatiana; Chang, Margaret H; Chen, Mary M; Melki, Imene; Lacroix, Steve; Iwakura, Yoichiro; Ware, Jerry; Gurish, Michael F; Italiano, Joseph E; Boilard, Eric; Nigrovic, Peter A

    2017-05-01

    The growth factor receptor Kit is involved in hematopoietic and nonhematopoietic development. Mice bearing Kit defects lack mast cells; however, strains bearing different Kit alleles exhibit diverse phenotypes. Herein, we investigated factors underlying differential sensitivity to IgG-mediated arthritis in 2 mast cell-deficient murine lines: KitWsh/Wsh, which develops robust arthritis, and KitW/Wv, which does not. Reciprocal bone marrow transplantation between KitW/Wv and KitWsh/Wsh mice revealed that arthritis resistance reflects a hematopoietic defect in addition to mast cell deficiency. In KitW/Wv mice, restoration of susceptibility to IgG-mediated arthritis was neutrophil independent but required IL-1 and the platelet/megakaryocyte markers NF-E2 and glycoprotein VI. In KitW/Wv mice, platelets were present in numbers similar to those in WT animals and functionally intact, and transfer of WT platelets did not restore arthritis susceptibility. These data implicated a platelet-independent role for the megakaryocyte, a Kit-dependent lineage that is selectively deficient in KitW/Wv mice. Megakaryocytes secreted IL-1 directly and as a component of circulating microparticles, which activated synovial fibroblasts in an IL-1-dependent manner. Transfer of WT but not IL-1-deficient megakaryocytes restored arthritis susceptibility to KitW/Wv mice. These findings identify functional redundancy among Kit-dependent hematopoietic lineages and establish an unanticipated capacity of megakaryocytes to mediate IL-1-driven systemic inflammatory disease.

  11. Design, Certification, and Deployment of the Colorimetric Water Quality Monitoring Kit (CWQMK)

    Science.gov (United States)

    Gazda, Daniel B.; Nolan, Daniel J.; Rutz, Jeff A.; Schultz, John R.; Siperko, Lorraine M.; Porter, Marc D.; Lipert, Robert J.; Flint, Stephanie M.; McCoy, J. Torin

    2010-01-01

    In August 2009, an experimental water quality monitoring kit based on Colorimetric Solid Phase Extraction (CSPE) technology was delivered to the International Space Station (ISS) aboard STS-128/17A. The kit, called the Colorimetric Water Quality Monitoring Kit (CWQMK), was flown and deployed as a Station Development Test Objective (SDTO) experiment on the ISS. The goal of the SDTO experiment is to evaluate the acceptability of CSPE technology for routine water quality monitoring on the ISS. This paper provides an overview of the SDTO experiment, as well as a detailed description of the CWQMK hardware and a summary of the testing and analysis conducted to certify the CWQMK for use on the ISS. The initial results obtained from the SDTO experiment are also reported and discussed in detail

  12. Press kit kicks off new branding.

    Science.gov (United States)

    Rees, Tom

    2004-01-01

    A smartly produced press kit resulted in unprecedented news coverage when Denver's Porter Adventist Hospital recently unveiled plans for an extensive 80 million dollars redevelopment. A news conference was held to announce this plan, along with the opening of the hospital's new emergency department. The overall effort is part of the new branding strategy of the 75-year-old hospital.

  13. Teen PACK: Population Awareness Campaign Kit.

    Science.gov (United States)

    Zero Population Growth, Inc., Washington, DC.

    This packet of instructional materials is designed to teach teenagers about the effects of overpopulation on the world and on the individual. Information is presented in three related booklets. The first of the three parts of the "Teen Population Awareness Campaign Kit," illustrates overpopulation through profiles of teens living in…

  14. Development of MIBI kit for heart imaging

    International Nuclear Information System (INIS)

    Khamis, S.B.; Ab-Wahid, M.

    1998-01-01

    99m Tc-isonitriles have been shown to be a very promising substitute for Thallium-201 ( 201 TI) for myocardial perfusion imaging. In this study, the lyophilized kit of Methoxyisobutylisonitrile (MIBI) was prepared and labeled with 99m Tc. Several factors affecting the labeling yield such as the kit's stannous content, boiling time during labeling, and the volume of 99m Tc used during reconstitution were also investigated. The radiochemical purity (RCP) determination of the labeled product was analyzed by HPLC, solvent-extraction, TLC and ITLC-SG chromatographic methods in various systems. Animal biodistribution study performed in rats indicated the 99m Tc-MIBI accumulation in the myocardial is up to 3 hours with little or no redistribution. Toxicity studies performed indicate no clinical signs of abnormality in mice at injected dose equivalent in amount of 100 times the human dose in proportion to body weight. Stability studies of the labeled complex performed at room temperature showed no change in radiochemical purity (> 95%) 6 hours post-preparation. Compatibility and comparative studies were done using both MINT and commercially available MIBI kits and 99m Tc generator eluates. From the results obtained the MINT produced MIBI kits were found to be comparable in quality to that of commercials. (author)

  15. Countdown to Six Billion Teaching Kit.

    Science.gov (United States)

    Zero Population Growth, Inc., Washington, DC.

    This teaching kit features six activities focused on helping students understand the significance of the world population reaching six billion for our society and our environment. Featured activities include: (1) History of the World: Part Six Billion; (2) A Woman's Place; (3) Baby-O-Matic; (4) Earth: The Apple of Our Eye; (5) Needs vs. Wants; and…

  16. CERN Rocks

    CERN Multimedia

    2004-01-01

    The 15th CERN Hardronic Festival took place on 17 July on the terrace of Rest 3 (Prévessin). Over 1000 people, from CERN and other International Organizations, came to enjoy the warm summer night, and to watch the best of the World's High Energy music. Jazz, rock, pop, country, metal, blues, funk and punk blasted out from 9 bands from the CERN Musiclub and Jazz club, alternating on two stages in a non-stop show.  The night reached its hottest point when The Canettes Blues Band got everybody dancing to sixties R&B tunes (pictured). Meanwhile, the bars and food vans were working at full capacity, under the expert management of the CERN Softball club, who were at the same time running a Softball tournament in the adjacent "Higgs Field". The Hardronic Festival is the main yearly CERN music event, and it is organized with the support of the Staff Association and the CERN Administration.

  17. Rock glaciers, Prealps, Vaud, Switzerland, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — The investigated area forms part of the western lobe of the Prealps (Swiss Prealps). The 25 identified fossil rock glaciers are found mainly in the Prealpes medianes...

  18. Remarks on some rock neutron parameters

    International Nuclear Information System (INIS)

    Czubek, J.A.

    1983-01-01

    A method to calculate the thermal neutron parameters (absorption cross-section, diffusion coefficient and diffusion length) of rocks is given. It is based on a proper energy averaging of cross-sections for all rock matrix and rock saturating liquid constituents. Special emphasis is given to the presence of hydrogen. The diffusion lengths in different lithologies in the function of the variable rock porosity have been calculated. An influence of the thermal neutron spectrum on the shape of the porosity calibration curves for the dual spacing neutron method is shown. This influence has been estimated on two porosity units, on average. (author)

  19. KIT safety management. Annual report 2013; KIT-Sicherheitsmanagement. Jahresbericht 2013

    Energy Technology Data Exchange (ETDEWEB)

    Frank, Gerhard (ed.)

    2014-07-01

    The KIT Safety Management Service Unit (KSM) guarantees radiological and conventional technical safety and security of Karlsruhe Institute of Technology and controls the implementation and observation of legal environmental protection requirements. KSM is responsible for licensing procedures, industrial safety organization, control of environmental protection measures, planning and implementation of emergency preparedness and response, operation of radiological laboratories and measurement stations, extensive radiation protection support and the execution of security tasks in and for all organizational units of KIT. Moreover, KSM is in charge of wastewater and environmental monitoring for all facilities and nuclear installations all over the KIT campus. KSM is headed by the Safety Commissioner of KIT, who is appointed by the Presidential Committee. Within his scope of procedure for KIT, the Safety Commissioner controls the implementation of and compliance with safety-relevant requirements. The KIT Safety Management is certified according to DIN EN ISO 9001, its laboratories are accredited according to DIN EN ISO/IEC 17025. To the extent possible, KSM is committed to maintaining competence in radiation protection and to supporting research and teaching activities. The present reports lists the individual tasks of the KIT Safety Management and informs about the results achieved in 2013. Status figures in principle reflect the status at the end of the year 2013. The processes described cover the areas of competence of KSM. Due to changes in the organization of the infrastructural service units in KIT, KSM has been cancelled at the end of 2013. Its tasks will mainly be covered in 2014 by the new founded service unit Safety and Environmental (Sicherheit und Umwelt, SUM). The departments Campus Security, Fire Brigade and Information Technology have been transferred to the Service Unit General Services (Allgemeine Services, ASERV).

  20. 46 CFR 121.710 - First-aid kits.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false First-aid kits. 121.710 Section 121.710 Shipping COAST... SYSTEMS AND EQUIPMENT Miscellaneous § 121.710 First-aid kits. A vessel must carry either a first-aid kit... kits, the contents must be stowed in a suitable, watertight container that is marked “First-Aid Kit”. A...

  1. Development of Safety Kit for Industrial Radiography Application

    International Nuclear Information System (INIS)

    Mohd Noorul Ikhsan Ahmad; Amry Amin Abas

    2011-01-01

    A safety kit for industrial radiography has been developed. The safety kit that consist of a set of technical rod and various size of base that can be used in radiograph of pipe with diameter between half and one and half inch with utilization of collimator. With the kit, radiographers will not having anymore problem to use collimator in their work. The paper discuss about the technical measures of the safety kit and the importance of introducing it to the industry. (author)

  2. [Consistency study of PowerPlex 21 kit and Goldeneye 20A kit and forensic application].

    Science.gov (United States)

    Ren, He; Liu, Ying; Zhang, Qing-Xia; Jiao, Zhang-Ping

    2014-06-01

    To ensure the consistency of genotype results for PowerPlex 21 kit and Goldeneye 20A kit. The STR loci were amplified in DNA samples from 205 unrelated individuals in Beijing Han population. And consistency of 19 overlap STR loci typing were observed. The genetic polymorphism of D1S1656 locus was obtained. All 19 overlap loci typing showed consistent. The proportion of peak height of heterozygous loci in two kits showed no statistical difference (P > 0.05). The observed heterozygosis of D1S1656 was 0.878. The discrimination power was 0.949. The excluding probability of paternity of triplet was 0.751. The excluding probability of paternity of diploid was 0.506. The polymorphism information content was 0.810. PowerPlex 21 kit and Goldeneye 20A kit present a good consistency. The primer design is reasonable. The polymorphism of D1S1656 is good. The two kits can be used for human genetic analysis, paternity test, and individual identification in forensic practice.

  3. Increasing Flight Software Reuse with OpenSatKit

    Science.gov (United States)

    McComas, David C.

    2018-01-01

    In January 2015 the NASA Goddard Space Flight Center (GSFC) released the Core Flight System (cFS) as open source under the NASA Open Source Agreement (NOSA) license. The cFS is based on flight software (FSW) developed for 12 spacecraft spanning nearly two decades of effort and it can provide about a third of the FSW functionality for a low-earth orbiting scientific spacecraft. The cFS is a FSW framework that is portable, configurable, and extendable using a product line deployment model. However, the components are maintained separately so the user must configure, integrate, and deploy them as a cohesive functional system. This can be very challenging especially for organizations such as universities building cubesats that have minimal experience developing FSW. Supporting universities was one of the primary motivators for releasing the cFS under NOSA. This paper describes the OpenSatKit that was developed to address the cFS deployment challenges and to serve as a cFS training platform for new users. It provides a fully functional out-of-the box software system that includes NASA's cFS, Ball Aerospace's command and control system COSMOS, and a NASA dynamic simulator called 42. The kit is freely available since all of the components have been released as open source. The kit runs on a Linux platform, includes 8 cFS applications, several kit-specific applications, and built in demos illustrating how to use key application features. It also includes the software necessary to port the cFS to a Raspberry Pi and instructions for configuring COSMOS to communicate with the target. All of the demos and test scripts can be rerun unchanged with the cFS running on the Raspberry Pi. The cFS uses a 3-tiered layered architecture including a platform abstraction layer, a Core Flight Executive (cFE) middle layer, and an application layer. Similar to smart phones, the cFS application layer is the key architectural feature for users to extend the FSW functionality to meet their

  4. 46 CFR 169.725 - First aid kit.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter. ...

  5. 46 CFR 108.707 - First aid kit.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false First aid kit. 108.707 Section 108.707 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Miscellaneous Equipment § 108.707 First aid kit. Each unit must have a first-aid kit approved by the Mine Safety...

  6. 33 CFR 144.01-30 - First-aid kit.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false First-aid kit. 144.01-30 Section...) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-30 First-aid kit. On each manned platform a first-aid kit approved by the Commandant or the U.S. Bureau of Mines shall be...

  7. 21 CFR 868.5140 - Anesthesia conduction kit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Anesthesia conduction kit. 868.5140 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5140 Anesthesia conduction kit. (a) Identification. An anesthesia conduction kit is a device used to administer to a patient conduction, regional, or...

  8. Trükitööstuste TOP 50

    Index Scriptorium Estoniae

    2002-01-01

    Trükitööstuste TOP 50. Käibe TOP 30. Käibe kasum TOP 30. Kasvu TOP 30. Kasumi kasvu TOP 30. Rentaabluse TOP. Varade tootlikkuse TOP. Trükitööstusettevõtete üldandmed. Trükitööstusettevõtete finantsandmed

  9. 21 CFR 864.2260 - Chromosome culture kit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Chromosome culture kit. 864.2260 Section 864.2260...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Cell And Tissue Culture Products § 864.2260 Chromosome culture kit. (a) Identification. A chromosome culture kit is a device containing the necessary ingredients...

  10. 21 CFR 878.3925 - Plastic surgery kit and accessories.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Plastic surgery kit and accessories. 878.3925... (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3925 Plastic surgery kit and accessories. (a) Identification. A plastic surgery kit and accessories is a device intended to...

  11. Escherichia coli and virus isolated from ''sticky kits''

    DEFF Research Database (Denmark)

    Jørgensen, M.; Scheutz, F.; Strandbygaard, Bertel

    1996-01-01

    A total of 121 Escherichia coli strains isolated from 3-week-old mink kits were serotyped and examined for virulence factors. 56 strains were isolated from healthy kits while 65 were from ''sticky kits''. Among these, 34 different serotypes were detected. No difference in serotypes or the presenc...

  12. Cardiac c-Kit Biology Revealed by Inducible Transgenesis.

    Science.gov (United States)

    Gude, Natalie A; Firouzi, Fareheh; Broughton, Kathleen M; Ilves, Kelli; Nguyen, Kristine P; Payne, Christina R; Sacchi, Veronica; Monsanto, Megan M; Casillas, Alexandria R; Khalafalla, Farid G; Wang, Bingyan J; Ebeid, David E; Alvarez, Roberto; Dembitsky, Walter P; Bailey, Barbara A; van Berlo, Jop; Sussman, Mark A

    2018-06-22

    Biological significance of c-Kit as a cardiac stem cell marker and role(s) of c-Kit+ cells in myocardial development or response to pathological injury remain unresolved because of varied and discrepant findings. Alternative experimental models are required to contextualize and reconcile discordant published observations of cardiac c-Kit myocardial biology and provide meaningful insights regarding clinical relevance of c-Kit signaling for translational cell therapy. The main objectives of this study are as follows: demonstrating c-Kit myocardial biology through combined studies of both human and murine cardiac cells; advancing understanding of c-Kit myocardial biology through creation and characterization of a novel, inducible transgenic c-Kit reporter mouse model that overcomes limitations inherent to knock-in reporter models; and providing perspective to reconcile disparate viewpoints on c-Kit biology in the myocardium. In vitro studies confirm a critical role for c-Kit signaling in both cardiomyocytes and cardiac stem cells. Activation of c-Kit receptor promotes cell survival and proliferation in stem cells and cardiomyocytes of either human or murine origin. For creation of the mouse model, the cloned mouse c-Kit promoter drives Histone2B-EGFP (enhanced green fluorescent protein; H2BEGFP) expression in a doxycycline-inducible transgenic reporter line. The combination of c-Kit transgenesis coupled to H2BEGFP readout provides sensitive, specific, inducible, and persistent tracking of c-Kit promoter activation. Tagging efficiency for EGFP+/c-Kit+ cells is similar between our transgenic versus a c-Kit knock-in mouse line, but frequency of c-Kit+ cells in cardiac tissue from the knock-in model is 55% lower than that from our transgenic line. The c-Kit transgenic reporter model reveals intimate association of c-Kit expression with adult myocardial biology. Both cardiac stem cells and a subpopulation of cardiomyocytes express c-Kit in uninjured adult heart

  13. Advantage of using a home-made ELISA kit for detection of Helicobacter pylori infection over commercially imported kits.

    Science.gov (United States)

    Mohammadi, M; Talebkhan, Y; Khalili, G; Mahboudi, F; Massarrat, S; Zamaninia, L; Oghalaei, A

    2008-01-01

    To evaluate a home-made ELISA kit for detection of Helicobacter pylori (Hp) infection and comparison of its immunologic criteria with those of foreign commercial kits. A home-made IgG ELISA kit was developed using soluble antigenic fractions of Hp proteins. Confirmed sera were tested and serological criteria were evaluated through assessment of 199 serum samples. The accuracy, sensitivity and specificity values of home-made kit were 92, 92 and 90.4%, respectively. These immunologic criteria for Trinity kit were 95.2, 95.2 and 95% in comparison with IBL kit (91.3, 92.2 and 88.5%), BIOHIT kit (72.4, 41.6 and 94.1%) and HelicoBlot2.1 (94.2, 93.4 and 100%). Kappa agreement assessment demonstrated that two of the imported ELISA kits had fair to moderate agreement with the home-made kit while the other one had a poor agreement value. Apart from comparable values between the home-made kit and the most efficient imported kit (Trinity) there was significant cost benefit. Therefore, we recommend the home-made kit as a suitable substitution for detection of Hp infection in the Iranian population.

  14. Advantage of using a home-made elisa kit for detection of Helicobacter pylori infection over commercially imported kits

    Directory of Open Access Journals (Sweden)

    Mohammadi M

    2008-01-01

    Full Text Available Purpose: To evaluate a home-made ELISA kit for detection of Helicobacter pylori (Hp infection and comparison of its immunologic criteria with those of foreign commercial kits. Methods: A home-made IgG ELISA kit was developed using soluble antigenic fractions of Hp proteins. Confirmed sera were tested and serological criteria were evaluated through assessment of 199 serum samples. Results: The accuracy, sensitivity and specificity values of home-made kit were 92, 92 and 90.4%, respectively. These immunologic criteria for Trinity kit were 95.2, 95.2 and 95% in comparison with IBL kit (91.3, 92.2 and 88.5%, BIOHIT kit (72.4, 41.6 and 94.1% and HelicoBlot2.1 (94.2, 93.4 and 100%. Kappa agreement assessment demonstrated that two of the imported ELISA kits had fair to moderate agreement with the home-made kit while the other one had a poor agreement value. Conclusions: Apart from comparable values between the home-made kit and the most efficient imported kit (Trinity there was significant cost benefit. Therefore, we recommend the home-made kit as a suitable substitution for detection of Hp infection in the Iranian population.

  15. Rollerjaw Rock Crusher

    Science.gov (United States)

    Peters, Gregory; Brown, Kyle; Fuerstenau, Stephen

    2009-01-01

    The rollerjaw rock crusher melds the concepts of jaw crushing and roll crushing long employed in the mining and rock-crushing industries. Rollerjaw rock crushers have been proposed for inclusion in geological exploration missions on Mars, where they would be used to pulverize rock samples into powders in the tens of micrometer particle size range required for analysis by scientific instruments.

  16. Shuttle performance enhancements using an OMS payload bay kit

    Science.gov (United States)

    Templin, Kevin C.; Mallini, Charles J.

    1991-01-01

    The study focuses on the use of an orbital maneuvering system (OMS) payload bay kit (PBK) designed to utilize OMS tanks identical to those currently employed in the Orbiter OMS pods. Emphasis is placed on payload deployment capability and payload servicing/reboost capability augmentation from the point of view of payload mass, maximum deployment altitudes, and initial retrieval and final deployment altitudes. The deployment, servicing, and reboost requirements of the Hubble Space Telescope and Advanced X-ray and Astrophysics Facility are analyzed in order to show the benefits an OMS PBK can provide for these missions. It is shown that OMS PBKs can provide the required capability enhancement necessary to support deployment, reboost, and servicing of payloads requiring altitudes greater than 325 nautical miles.

  17. Preparation and quality control of ECD kit

    International Nuclear Information System (INIS)

    Yassin, T.; Dadokh, M.; Almalki, R.

    2005-05-01

    ECD Kit for brain imaging after labeling with technetium 99m was prepared according to an optimum conditions, Each vial contains 1 mg of ECD and 0.155 mg of stannous chloride anhydrous SnCl 2 , 24 mg of Mannitol and 0.5 mg of Na 2 Ca EDTA, The prepared kit showed high quality satisfying the requirements of international pharmacopoeias from the points of physical, chemical, radiochemical and biological purities, and its validity for human injection. And the labeling yield exceeded 95 % with average value of about 97.63 ± 0.89% for 2mCi /2ml radioactivity , This study also showed that each vial content can be labeled with maximum activity of 99m Tc of about 50 mCi (Authors)

  18. KIT mutation analysis in mast cell neoplasms

    DEFF Research Database (Denmark)

    Arock, M; Sotlar, K; Akin, C

    2015-01-01

    mutations in patients with mastocytosis at diagnosis and during follow-up with sufficient precision and sensitivity in daily practice. In addition, we provide recommendations for sampling and storage of diagnostic material as well as a robust diagnostic algorithm. Using highly sensitive assays, KIT D816V...... can be detected in peripheral blood leukocytes from most patients with systemic mastocytosis (SM) that is a major step forward in screening and SM diagnosis. In addition, the KIT D816V allele burden can be followed quantitatively during the natural course or during therapy. Our recommendations should...... greatly facilitate diagnostic and follow-up investigations in SM in daily practice as well as in clinical trials. In addition, the new tools and algorithms proposed should lead to a more effective screen, early diagnosis of SM and help to avoid unnecessary referrals....

  19. Unitized solid phase immunoassay kit and method

    International Nuclear Information System (INIS)

    1975-01-01

    A unitized solid phase kit for radioimmunoassay is disclosed. All of the necessary assay reagents are incorporated into a single tube wherein all phases of the assay procedure are performed, requiring only the addition of the patient's sample. Antibody is bound to the tube surface while labelled antigen is also present but unbound. Storage in the absence of air and water results in the stabilization of the reagents such that the system can be stored for long periods

  20. Automated prototyping tool-kit (APT)

    OpenAIRE

    Nada, Nader; Shing, M.; Berzins, V.; Luqi

    2002-01-01

    Automated prototyping tool-kit (APT) is an integrated set of software tools that generate source programs directly from real-time requirements. The APT system uses a fifth-generation prototyping language to model the communication structure, timing constraints, 1/0 control, and data buffering that comprise the requirements for an embedded software system. The language supports the specification of hard real-time systems with reusable components from domain specific component libraries. APT ha...

  1. Computerized portable microwave hyperthermia quality assurance kit

    International Nuclear Information System (INIS)

    Cheung, A.Y.; Neyzari, A.

    1985-01-01

    A computerized quality assurance kit to provide precise measurement and calibration of microwave power and temperature, as well as capabilities to map SAR (Specific absorption rate) distribution in phantoms; and survey of hazardous microwave leakage has been designed. The kit is also capable of performing corelation studies on the relationship between SAR and net microwave power delivered at various anatomical sites. The kit consists of a portable microcomputer, a time-multiplexed A/D converter, a 4-channel dual directional microwave power monitor, a 4-channel thin-wire thermocouple thermometry system, an electronic thermal calibrator, a microwave leakage hazard survey meter, and a dynamic phantom tank for dosimetric analysis. Comparative performance studies were made against NBS-traceable power and temperature standards, non-perturbing optical temperature sensors, and established power and temperature measurement devices. The test results indicate that this instrument is providing its user with measurement accuracy of 0.1 0 C in temperature, 10% accuracy in power. The thin-wire thermocouple, with computer assisted error compensation, performs equally well in a strong microwave field in comparison with non-perturbing optical temperature sensors

  2. c-KIT positive schistosomal urinary bladder carcinoma are frequent but lack KIT gene mutations.

    Science.gov (United States)

    Shams, Tahany M; Metawea, Mokhtar; Salim, Elsayed I

    2013-01-01

    Urinary bladder squamous cell carcinoma (SCC), one of the most common neoplasms in Egypt, is attributed to chronic urinary infection with Schistosoma haematobium (Schistosomiasis). The proto-oncogene c-KIT, encoding a tyrosine kinase receptor and implicated in the development of a number of human malignancies, has not been studied so far in schistosomal urinary bladder SCCs. We therefore determined immunohistochemical (IHC) expression of c-KIT in paraffin sections from 120 radical cystectomies of SCCs originally obtained from the Pathology Department of Suez Canal University (Ismailia, Egypt). Each slide was evaluated for staining intensity where the staining extent of >10% of cells was considered positive. c-KIT overexpression was detected in 78.3% (94/120) of the patients, the staining extents in the tumor cells were 11-50% and >50% in 40 (42.6%) and 54 (57.4%) respectively. The positive cases had 14.9%, 63.8%, 21.3% as weak, moderate and strong intensity respectively. Patients with positive bilharzial ova had significantly higher c-KIT expression than patients without (95.2% vs. 38.9%, P=0.000). Mutation analysis of exons 9-13 was negative in thirty KIT positive cases. The high rate of positivity in SBSCC was one of the striking findings; However, CD117 may be a potential target for site specific immunotherapy to improve the outcome of this tumor.

  3. Fracture characteristics in Japanese rock

    International Nuclear Information System (INIS)

    Ijiri, Yuji; Sawada, Atsushi; Akahori, Kuniaki

    1999-11-01

    It is crucial for the performance assessment of geosphere to evaluate the characteristics of fractures that can be dominant radionuclide migration pathways from a repository to biosphere. This report summarizes the characteristics of fractures obtained from broad literature surveys and the fields surveys at the Kamaishi mine in northern Japan and at outcrops and galleries throughout the country. The characteristics of fractures described in this report are fracture orientation, fracture shape, fracture frequency, fracture distribution in space, transmissivity of fracture, fracture aperture, fracture fillings, alteration halo along fracture, flow-wetted surface area in fracture, and the correlation among these characteristics. Since granitic rock is considered the archetype fractured media, a large amount of fracture data is available in literature. In addition, granitic rock has been treated as a potential host rock in many overseas programs, and has JNC performed a number of field observations and experiments in granodiorite at the Kamaishi mine. Therefore, the characteristics of fractures in granitic rock are qualitatively and quantitatively clarified to some extent in this report, while the characteristics of fractures in another rock types are not clarified. (author)

  4. Technetium-99m ceftizoxime kit preparation

    International Nuclear Information System (INIS)

    Diniz, Simone Odilia Fernandes; Siqueira, Cristiano Ferrari; Nelson, David Lee; Cardoso, Valbert Nascimento

    2005-01-01

    The aim of this work was to prepare a kit of 99 m Tc-ceftizoxime ( 99m Tc-CFT), with stability and biological activity preserved, able to identify a septic focus (E. coli) in the experimental infection model in rats. The preparation of the CFT kit involved the use of lyophilized solutions containing the antibiotic ceftizoxime and the sodium dithionite reducing agent (6.0 mg/m L). After lyophilization, the kit was reconstituted with 1.0 mL of sodium 99m Tc pertechnetate solution (Na 99m Tc O 4- ) with an activity of 370 MBq. The solution was boiled for 10 min and filtered through a cellulose ester filter. The labeling efficiency was on the order of 92%, remaining stable for six hours and the kit remained stable for two months. The biological activity of the 99m Tc-CFT was evaluated by diffusion in agar impregnated with E.coli and S. aureus. Seven Wistar rats, weighing from 200 to 250 g, were used for the development of the septic focus. After 24 hours from the induction of the infectious site (E.coli), the animals were anesthetized and 0.1 mL of 99m Tc-CFT (37 MBq) was injected into the tail veins of the animals. The images were obtained with a gamma camera one, two and six hours after injection and the regions of interest (ROIs) were calculated. The diameters of the inhibition halos for 99 m Tc-CFT were 27.16 ± 0.23 and 27.17 ± 0.20 for S.aureus and E.coli, respectively, while those for the unlabeled CFT were 30.4 ± 0.33 and 29.43 ± 0.26, respectively. The results for the biodistribution of 99m Tc-CFT in infected animals furnished a ratio of 1.97 ± 0.31, 2.10 ± 0.42 and 2.01 ± 0.42 for cpm-target/cpm-no target for the one, two and six-hour periods, respectively. The images showed a clear uptake of labeled antibiotic ( 99m Tc-CFT) by the infectious site during the experiment. The results attest to the viability of producing a kit with 99m technetium-labeled ceftizoxime for the investigation of infectious processes. (author)

  5. Technetium-99m ceftizoxime kit preparation

    Energy Technology Data Exchange (ETDEWEB)

    Diniz, Simone Odilia Fernandes; Siqueira, Cristiano Ferrari; Nelson, David Lee; Cardoso, Valbert Nascimento [Minas Gerais Univ. Federal, Belo Horizonte, MG (Brazil). Faculdade de Farmacia]. E-mail: simone@farmacia.ufmg.br; Martin-Comin, Josep [Bellvitge Univ., Barcelona (Spain)

    2005-10-15

    The aim of this work was to prepare a kit of {sup 99}m Tc-ceftizoxime ({sup 99m} Tc-CFT), with stability and biological activity preserved, able to identify a septic focus (E. coli) in the experimental infection model in rats. The preparation of the CFT kit involved the use of lyophilized solutions containing the antibiotic ceftizoxime and the sodium dithionite reducing agent (6.0 mg/m L). After lyophilization, the kit was reconstituted with 1.0 mL of sodium {sup 99m} Tc pertechnetate solution (Na {sup 99m} Tc O{sub 4-}) with an activity of 370 MBq. The solution was boiled for 10 min and filtered through a cellulose ester filter. The labeling efficiency was on the order of 92%, remaining stable for six hours and the kit remained stable for two months. The biological activity of the {sup 99m} Tc-CFT was evaluated by diffusion in agar impregnated with E.coli and S. aureus. Seven Wistar rats, weighing from 200 to 250 g, were used for the development of the septic focus. After 24 hours from the induction of the infectious site (E.coli), the animals were anesthetized and 0.1 mL of {sup 99m} Tc-CFT (37 MBq) was injected into the tail veins of the animals. The images were obtained with a gamma camera one, two and six hours after injection and the regions of interest (ROIs) were calculated. The diameters of the inhibition halos for {sup 99}m Tc-CFT were 27.16 {+-} 0.23 and 27.17 {+-} 0.20 for S.aureus and E.coli, respectively, while those for the unlabeled CFT were 30.4 {+-} 0.33 and 29.43 {+-} 0.26, respectively. The results for the biodistribution of {sup 99m} Tc-CFT in infected animals furnished a ratio of 1.97 {+-} 0.31, 2.10 {+-} 0.42 and 2.01 {+-} 0.42 for cpm-target/cpm-no target for the one, two and six-hour periods, respectively. The images showed a clear uptake of labeled antibiotic ({sup 99m} Tc-CFT) by the infectious site during the experiment. The results attest to the viability of producing a kit with {sup 99m} technetium-labeled ceftizoxime for the

  6. Electrochemistry of lunar rocks

    Science.gov (United States)

    Lindstrom, D. J.; Haskin, L. A.

    1979-01-01

    Electrolysis of silicate melts has been shown to be an effective means of producing metals from common silicate materials. No fluxing agents need be added to the melts. From solution in melts of diopside (CaMgSi2O6) composition, the elements Si, Ti, Ni, and Fe have been reduced to their metallic states. Platinum is a satisfactory anode material, but other cathode materials are needed. Electrolysis of compositional analogs of lunar rocks initially produces iron metal at the cathode and oxygen gas at the anode. Utilizing mainly heat and electricity which are readily available from sunlight, direct electrolysis is capable of producing useful metals from common feedstocks without the need for expendable chemicals. This simple process and the products obtained from it deserve further study for use in materials processing in space.

  7. Effects of confinement on rock mass modulus: A synthetic rock mass modelling (SRM study

    Directory of Open Access Journals (Sweden)

    I. Vazaios

    2018-06-01

    Full Text Available The main objective of this paper is to examine the influence of the applied confining stress on the rock mass modulus of moderately jointed rocks (well interlocked undisturbed rock mass with blocks formed by three or less intersecting joints. A synthetic rock mass modelling (SRM approach is employed to determine the mechanical properties of the rock mass. In this approach, the intact body of rock is represented by the discrete element method (DEM-Voronoi grains with the ability of simulating the initiation and propagation of microcracks within the intact part of the model. The geometry of the pre-existing joints is generated by employing discrete fracture network (DFN modelling based on field joint data collected from the Brockville Tunnel using LiDAR scanning. The geometrical characteristics of the simulated joints at a representative sample size are first validated against the field data, and then used to measure the rock quality designation (RQD, joint spacing, areal fracture intensity (P21, and block volumes. These geometrical quantities are used to quantitatively determine a representative range of the geological strength index (GSI. The results show that estimating the GSI using the RQD tends to make a closer estimate of the degree of blockiness that leads to GSI values corresponding to those obtained from direct visual observations of the rock mass conditions in the field. The use of joint spacing and block volume in order to quantify the GSI value range for the studied rock mass suggests a lower range compared to that evaluated in situ. Based on numerical modelling results and laboratory data of rock testing reported in the literature, a semi-empirical equation is proposed that relates the rock mass modulus to confinement as a function of the areal fracture intensity and joint stiffness. Keywords: Synthetic rock mass modelling (SRM, Discrete fracture network (DFN, Rock mass modulus, Geological strength index (GSI, Confinement

  8. Technetium-99m ceftizoxime kit preparation

    Directory of Open Access Journals (Sweden)

    Simone Odília Fernandes Diniz

    2005-10-01

    Full Text Available The aim of this work was to prepare a kit of 99mTc-ceftizoxime (99mTc-CFT, with stability and biological activity preserved, able to identify a septic focus (E. coli in the experimental infection model in rats. The preparation of the CFT kit involved the use of lyophilized solutions containing the antibiotic ceftizoxime and the sodium dithionite reducing agent (6.0 mg/mL. After lyophilization, the kit was reconstituted with 1.0 mL of sodium 99mTc-pertechnetate solution (Na99mTcO4- with an activity of 370 MBq. The solution was boiled for 10 min and filtered through a cellulose ester filter. The labeling efficiency was on the order of 92%, remaining stable for six hours and the kit remained stable for two months. The biological activity of the 99mTc-CFT was evaluated by diffusion in agar impregnated with E.coli and S. aureus. Seven Wistar rats, weighing from 200 to 250 g, were used for the development of the septic focus. After 24 hours from the induction of the infectious site (E.coli, the animals were anesthetized and 0.1 mL of 99mTc-CFT (37 MBq was injected into the tail veins of the animals. The images were obtained with a gamma camera one, two and six hours after injection and the regions of interest (ROIs were calculated. The diameters of the inhibition halos for 99mTc-CFT were 27.16 ± 0.23 and 27.17 ± 0.20 for S.aureus and E.coli, respectively, while those for the unlabeled CFT were 30.4 ± 0.33 and 29.43 ± 0.26, respectively. The results for the biodistribution of 99mTc-CFT in infected animals furnished a ratio of 1.97 ± 0.31, 2.10 ± 0.42 and 2.01 ± 0.42 for cpm-target/cpm-no target for the one, two and six-hour periods, respectively. The images showed a clear uptake of labeled antibiotic (99mTc-CFT by the infectious site during the experiment. The results attest to the viability of producing a kit with 99m technetium-labeled ceftizoxime for the investigation of infectious processes.O objetivo deste trabalho foi preparar um kit de Tc

  9. Rocks Can Wow? Yes, Rocks Can Wow!

    Science.gov (United States)

    Hardman, Sally; Luke, Sue

    2016-01-01

    Rocks and fossils appear in the National Curriculum of England science programmes of study for children in year 3 (ages 7-8). A frequently asked question is "How do you make the classification of rocks engaging?" In response to this request from a school, a set of interactive activities was designed and organised by tutors and students…

  10. Development of kits for total PSA monitoring

    International Nuclear Information System (INIS)

    Suprarop, P.

    1999-01-01

    The development of kits for Total PSA assay has shown promising results. All essential components of the assay were prepared with reproducibility and used to optimize the assay. By choosing two steps method, we could avoid the hook effect and obtain satisfactory Q.C. parameters of the standard curve i.e. blank = 0.8%, maximum binding = 65%. If reference material for calibration of the standard is agree upon, the validation could then be carried out with total confidence. Our final goal is to reduce the step of incubation to just one step with no interference from hook effect

  11. Euthanasia: a "kit" sold in Belgian pharmacies.

    Science.gov (United States)

    2005-10-01

    (1) In France, legislation adopted in 2005 recognises the right of dying patients to refuse further treatment, and the right of physicians to ease their suffering with treatments that, due to adverse effects, may shorten their life. Measures deliberately aimed at hastening death are forbidden. (2) In Belgium, medical euthanasia was decriminalised in 2002, and can now be carried out either in hospital or at home. Nearly 20 cases of euthanasia are reported per month in Belgium. (3) A Belgian pharmacy chain now markets a "euthanasia kit".

  12. Personal Computer-less (PC-less) Microcontroller Training Kit

    Science.gov (United States)

    Somantri, Y.; Wahyudin, D.; Fushilat, I.

    2018-02-01

    The need of microcontroller training kit is necessary for practical work of students of electrical engineering education. However, to use available training kit not only costly but also does not meet the need of laboratory requirements. An affordable and portable microcontroller kit could answer such problem. This paper explains the design and development of Personal Computer Less (PC-Less) Microcontroller Training Kit. It was developed based on Lattepanda processor and Arduino microcontroller as target. The training kit equipped with advanced input-output interfaces that adopted the concept of low cost and low power system. The preliminary usability testing proved this device can be used as a tool for microcontroller programming and industrial automation training. By adopting the concept of portability, the device could be operated in the rural area which electricity and computer infrastructure are limited. Furthermore, the training kit is suitable for student of electrical engineering student from university and vocational high school.

  13. Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.

    OpenAIRE

    Reith, A D; Ellis, C; Lyman, S D; Anderson, D M; Williams, D E; Bernstein, A; Pawson, T

    1991-01-01

    Germline mutations at the Dominant White Spotting (W) and Steel (Sl) loci have provided conclusive genetic evidence that c-kit mediated signal transduction pathways are essential for normal mouse development. We have analysed the interactions of normal and mutant W/c-kit gene products with cytoplasmic signalling proteins, using transient c-kit expression assays in COS cells. In addition to the previously identified c-kit gene product (Kit+), a second normal Kit isoform (KitA+) containing an i...

  14. Rock slope design guide.

    Science.gov (United States)

    2011-04-01

    This Manual is intended to provide guidance for the design of rock cut slopes, rockfall catchment, and : rockfall controls. Recommendations presented in this manual are based on research presented in Shakoor : and Admassu (2010) entitled Rock Slop...

  15. Rock Slope Design Criteria

    Science.gov (United States)

    2010-06-01

    Based on the stratigraphy and the type of slope stability problems, the flat lying, Paleozoic age, sedimentary : rocks of Ohio were divided into three design units: 1) competent rock design unit consisting of sandstones, limestones, : and siltstones ...

  16. The Rock Cycle

    Science.gov (United States)

    Singh, Raman J.; Bushee, Jonathan

    1977-01-01

    Presents a rock cycle diagram suitable for use at the secondary or introductory college levels which separates rocks formed on and below the surface, includes organic materials, and separates products from processes. (SL)

  17. To Kit or Not to Kit? Evaluating and Implementing Science Materials and Resources

    Science.gov (United States)

    Schiller, Ellen; Melin, Jacque; Bair, Mary

    2016-01-01

    With the release of the "Next Generation Science Standards," many schools are reexamining the science materials they are using. Textbook companies and kit developers are eager to meet the demand for "NGSS"-aligned teaching materials. Teacher may have been asked to serve on a science curriculum committee, or to evaluate current…

  18. Selling Addiction: A Workshop Kit on Tobacco and Alcohol Advertising. A Media Literacy Workshop Kit.

    Science.gov (United States)

    Barnes, Mary Ellen; And Others

    This kit consists of: (1) a leader's guide; (2) an 18-minute videotape containing three 6-minute discussion starter segments analyzing typical commercials and advertising techniques; (3) a special issue of "Media Values" magazine on the theme "Fatal Attraction: The Selling of Addiction"; (4) an 8-page booklet "Awareness to Action: Media Literacy…

  19. Disposable Collection Kit for Rapid and Reliable Collection of Saliva

    OpenAIRE

    Yamaguchi, Masaki; Tezuka, Yuki; Takeda, Kazunori; Shetty, Vivek

    2015-01-01

    Objectives To describe and evaluate disposable saliva collection kit for rapid, reliable, and reproducible collection of saliva samples. Methods The saliva collection kit comprised of a saliva absorbent swab and an extractor unit was used to retrieve whole saliva samples from 10 subjects. The accuracy and precision of the extracted volumes (3, 10, and 30 ?l) were compared to similar volumes drawn from control samples obtained by passive drool. Additionally, the impact of kit collection method...

  20. Opportunities of the energy revolution. Scientific contributions to the KIT

    International Nuclear Information System (INIS)

    Breh, Wolfgang; Schaetzler, Katharina

    2013-01-01

    ''Opportunities for energy revolution'' was the title under which the KIT Energy Center of Karlsruhe Institute of Technology (KIT) in May 2012 held its first annual meeting. The meeting covered the whole Topic of the KIT Energy Center. The present proceedings give those interested the opportunity to delve into the contributions and to provide a differentiated picture of the challenges and opportunities of the energy transition.

  1. IODOBELL in vivo kits for in situ labelling with iodine

    International Nuclear Information System (INIS)

    Koernyei, Jozsef; Lakatos, Mihaly; Kecskes, Ferenc; Mahunka, Imre; Mikecz, Pal; Ando, Laszlo

    1988-01-01

    A system of in vivo kits called IODOBELL was developed in the Institute of Isotopes, Budapest. The production of hepatodecanoic acid for cardiology, iodo-hippuranic acid for kidney diagnostics and a special pharmaceutical, IODOBELL-MIGB for the indication of feochromocitoma and neuroblastoma is reported. The heptadecanoic acid kit is under human examination, the other two are to be tested in the near future. IODOBELL kits contribute to the wider use of 123 I in Hungary. (author) 6 refs

  2. Experience with Phadebas hCS (HPL)-Test kit

    International Nuclear Information System (INIS)

    Herter, U.

    1976-01-01

    The RIA determination of human placental lactogen (HPL) is described using the Phadebas test kit by Pharmacia, Sweden. The results of the test are shown graphically. The kit was tested over a period of one year and the tests were modified to meet the requirements of clinical examinations. The calibration curve is constant and applicable for a period of 14 days. The Phadebas kit has proved to be advantageous for both scientific research work and for routine clinical examinations. (L.O.)

  3. FUELS IN SOIL TEST KIT: FIELD USE OF DIESEL DOG SOIL TEST KITS

    Energy Technology Data Exchange (ETDEWEB)

    Susan S. Sorini; John F. Schabron; Joseph F. Rovani, Jr.

    2002-09-30

    Western Research Institute (WRI) has developed a new commercial product ready for technology transfer, the Diesel Dog{reg_sign} Portable Soil Test Kit, for performing analysis of fuel-contaminated soils in the field. The technology consists of a method developed by WRI (U.S. Patents 5,561,065 and 5,976,883) and hardware developed by WRI that allows the method to be performed in the field (patent pending). The method is very simple and does not require the use of highly toxic reagents. The aromatic components in a soil extract are measured by absorption at 254 nm with a field-portable photometer. WRI added significant value to the technology by taking the method through the American Society for Testing and Materials (ASTM) approval and validation processes. The method is designated as ASTM Method D 5831-96, Standard Test Method for Screening Fuels in Soils. This ASTM designation allows the method to be used for federal compliance activities. In June 2001, the Diesel Dog technology won an American Chemical Society Regional Industrial Innovations Award. To gain field experience with the new technology, Diesel Dog kits have been used for a variety of site evaluation and cleanup activities. Information gained from these activities has led to improvements in hardware configurations and additional insight into correlating Diesel Dog results with results from laboratory methods. The Wyoming Department of Environmental Quality (DEQ) used Diesel Dog Soil Test Kits to guide cleanups at a variety of sites throughout the state. ENSR, of Acton, Massachusetts, used a Diesel Dog Portable Soil Test Kit to evaluate sites in the Virgin Islands and Georgia. ChemTrack and the U.S. Army Corps of Engineers successfully used a test kit to guide excavation at an abandoned FAA fuel-contaminated site near Fairbanks, Alaska. Barenco, Inc. is using a Diesel Dog Portable Soil Test Kit for site evaluations in Canada. A small spill of diesel fuel was cleaned up in Laramie, Wyoming using a Diesel

  4. c-Kit signaling determines neointimal hyperplasia in arteriovenous fistulae

    Science.gov (United States)

    Skartsis, Nikolaos; Martinez, Laisel; Duque, Juan Camilo; Tabbara, Marwan; Velazquez, Omaida C.; Asif, Arif; Andreopoulos, Fotios; Salman, Loay H.

    2014-01-01

    Stenosis of arteriovenous (A-V) fistulae secondary to neointimal hyperplasia (NIH) compromises dialysis delivery, which worsens patients' quality of life and increases medical costs associated with the maintenance of vascular accesses. In the present study, we evaluated the role of the receptor tyrosine kinase c-Kit in A-V fistula neointima formation. Initially, c-Kit was found in the neointima and adventitia of human brachiobasilic fistulae, whereas it was barely detectable in control veins harvested at the time of access creation. Using the rat A-V fistula model to study venous vascular remodeling, we analyzed the spatial and temporal pattern of c-Kit expression in the fistula wall. Interestingly, c-Kit immunoreactivity increased with time after anastomosis, which concurred with the accumulation of cells in the venous intima. In addition, c-Kit expression in A-V fistulae was positively altered by chronic kidney failure conditions. Both blockade of c-Kit with imatinib mesylate (Gleevec) and inhibition of stem cell factor production with a specific short hairpin RNA prevented NIH in the outflow vein of experimental fistulae. In agreement with these data, impaired c-Kit activity compromised the development of NIH in A-V fistulae created in c-KitW/Wv mutant mice. These results suggest that targeting of the c-Kit signaling pathway may be an effective approach to prevent postoperative NIH in A-V fistulae. PMID:25186298

  5. Statistical modeling of dental unit water bacterial test kit performance.

    Science.gov (United States)

    Cohen, Mark E; Harte, Jennifer A; Stone, Mark E; O'Connor, Karen H; Coen, Michael L; Cullum, Malford E

    2007-01-01

    While it is important to monitor dental water quality, it is unclear whether in-office test kits provide bacterial counts comparable to the gold standard method (R2A). Studies were conducted on specimens with known bacterial concentrations, and from dental units, to evaluate test kit accuracy across a range of bacterial types and loads. Colony forming units (CFU) were counted for samples from each source, using R2A and two types of test kits, and conformity to Poisson distribution expectations was evaluated. Poisson regression was used to test for effects of source and device, and to estimate rate ratios for kits relative to R2A. For all devices, distributions were Poisson for low CFU/mL when only beige-pigmented bacteria were considered. For higher counts, R2A remained Poisson, but kits exhibited over-dispersion. Both kits undercounted relative to R2A, but the degree of undercounting was reasonably stable. Kits did not grow pink-pigmented bacteria from dental-unit water identified as Methylobacterium rhodesianum. Only one of the test kits provided results with adequate reliability at higher bacterial concentrations. Undercount bias could be estimated for this device and used to adjust test kit results. Insensitivity to methylobacteria spp. is problematic.

  6. Chemistry of /sup 99m/Tc labeling kits

    International Nuclear Information System (INIS)

    Srivastava, S.C.; Meinken, G.; Richards, P.

    1976-01-01

    Problems have been reported with the use of kit-produced /sup 99m/Tc radiopharmaceuticals. This study was undertaken to understand the chemistry involved in various stannous kit systems. The relation between Tc, tin, and the ligands used to complex the reduced Tc was investigated. It is concluded that for reliable performance, stannous kits should be prepared so that most of the tin is kept in the usable (reducing) form; a solution would be to use minimum tin and a large excess of complexing agent. Oxidation of the Tc complex to free pertechnetate is not a major problem in most kit systems. 5 figures

  7. Underground large scale test facility for rocks

    International Nuclear Information System (INIS)

    Sundaram, P.N.

    1981-01-01

    This brief note discusses two advantages of locating the facility for testing rock specimens of large dimensions in an underground space. Such an environment can be made to contribute part of the enormous axial load and stiffness requirements needed to get complete stress-strain behavior. The high pressure vessel may also be located below the floor level since the lateral confinement afforded by the rock mass may help to reduce the thickness of the vessel

  8. The Virtual Physiological Human ToolKit.

    Science.gov (United States)

    Cooper, Jonathan; Cervenansky, Frederic; De Fabritiis, Gianni; Fenner, John; Friboulet, Denis; Giorgino, Toni; Manos, Steven; Martelli, Yves; Villà-Freixa, Jordi; Zasada, Stefan; Lloyd, Sharon; McCormack, Keith; Coveney, Peter V

    2010-08-28

    The Virtual Physiological Human (VPH) is a major European e-Science initiative intended to support the development of patient-specific computer models and their application in personalized and predictive healthcare. The VPH Network of Excellence (VPH-NoE) project is tasked with facilitating interaction between the various VPH projects and addressing issues of common concern. A key deliverable is the 'VPH ToolKit'--a collection of tools, methodologies and services to support and enable VPH research, integrating and extending existing work across Europe towards greater interoperability and sustainability. Owing to the diverse nature of the field, a single monolithic 'toolkit' is incapable of addressing the needs of the VPH. Rather, the VPH ToolKit should be considered more as a 'toolbox' of relevant technologies, interacting around a common set of standards. The latter apply to the information used by tools, including any data and the VPH models themselves, and also to the naming and categorizing of entities and concepts involved. Furthermore, the technologies and methodologies available need to be widely disseminated, and relevant tools and services easily found by researchers. The VPH-NoE has thus created an online resource for the VPH community to meet this need. It consists of a database of tools, methods and services for VPH research, with a Web front-end. This has facilities for searching the database, for adding or updating entries, and for providing user feedback on entries. Anyone is welcome to contribute.

  9. Rock History and Culture

    OpenAIRE

    Gonzalez, Éric

    2013-01-01

    Two ambitious works written by French-speaking scholars tackle rock music as a research object, from different but complementary perspectives. Both are a definite must-read for anyone interested in the contextualisation of rock music in western popular culture. In Une histoire musicale du rock (i.e. A Musical History of Rock), rock music is approached from the point of view of the people – musicians and industry – behind the music. Christophe Pirenne endeavours to examine that field from a m...

  10. A comparative study in three commercial kits of radioligand assay for GAD-Ab

    International Nuclear Information System (INIS)

    Yang Yehua; Zhou Zhiguang; Huang Gan; Yang Feike; Li Zhangwei

    2006-01-01

    Objective: To provide data for perfect selection of glutamic acid decarboxylase antibodies (GAD-Ab) assay commercial kits. Methods: The sera of 88 titer-graded samples by radioligand assay (RLA) were measured with two types of enzyme-linked immunosorbent assay (ELISA) kits and one type of immunoradiometric assay (IRMA) kit for GAD-Ab in order to test their consistency with RLA. Another 140 diabetic sera were measured with RLA and screened by a type of suitable kit to search the cutoff point for discriminating patients who needed rechecking. Results: Compared with RLA, concordance ratio of 3 kits: Medizym kit(75%) > RSR kit(73.9%) > Biomerica kit(62.5%); Kappa value: Medizym kit (0.408, common) > RSR kit (0.405, common) > Biomerica kit (0.185, failing); correlation to RLA index: RSR kit (r= 0.992) > Medizym kit(r= 0. 791 ) > Biomerica kit (r = -0. 055); area under the receiver operating characteristic (ROC) curve: Medizym kit (0.812) > RSR kit (0. 727 ) > Biomerica kit (0.666). Conclusions: The efficiencies of RSR kit and Medizym kit are good. Serum concentration between 0.25-0.99 U/ml measured by RSR kit is suggested to further recheck by RLA. (authors)

  11. Energy Education Incentives: Evaluating the Impact of Consumer Energy Kits

    Science.gov (United States)

    Kirby, Sarah D.; Guin, Autumn; Langham, Laura

    2015-01-01

    Measuring the energy and environmental impact of residential energy education efforts is difficult. The E-Conservation residential energy management program uses consumer energy kits to document the impact of energy-efficient improvements. The consumer energy kit provides an incentive for individuals attending energy education workshop, helps…

  12. Screening of antibiotics residues and development a new kit

    International Nuclear Information System (INIS)

    Elkhaoui, Faycel

    2009-01-01

    The first part of the work was to detect antibiotic residues in animal nutriment: chicken, fish, eggs and milk, by methods of screening: First Test and Delvotest. The second part covered the development of a new kit for the detection of antibiotics residues for honey and competitor kit First Test and saving time and money.

  13. Indoor Air Quality Tools for Schools Action Kit. Second Edition.

    Science.gov (United States)

    Environmental Protection Agency, Washington, DC.

    This kit contains materials to assist a school indoor air quality (IAQ) coordinator in conducting a school IAQ program. The kit contains the following: IAQ coordinator's guide; IAQ coordinator forms; IAQ backgrounder; teacher's classroom checklist; administrative staff checklist; health officer/school nurse checklist; ventilation checklist and…

  14. Development of ELISA kit for rat albumin

    International Nuclear Information System (INIS)

    Yuan Zhigang; Han Shiquan; Liu Yibing; Xu Wenge; Jia Juanjuan

    2009-01-01

    The Anti-rat albumin serum was prepared by immunized the sheep with rat albumin. A ELISA method was established for rat albumin. The measurement range of the assay was 1-50 mg/L, sensitivity of the assay was 0.42 mg/L, recovery rate was 85.0%-106.0%. Intra-and inter-assay variation coefficients were <8.9% and <12.8% respectively. The correlation coefficients between measured and expected values were 0.999 after serial dilution of the urine samples with high concentrations of rat albumin. A good correlation was observed between the ELISA and RIA methods, and the kit for rat albumin might provide a convenience in exploitation of renal drugs and experimental injury of the kidney. (authors)

  15. A decrease in ubiquitination and resulting prolonged life-span of KIT underlies the KIT overexpression-mediated imatinib resistance of KIT mutation-driven canine mast cell tumor cells.

    Science.gov (United States)

    Kobayashi, Masato; Kuroki, Shiori; Kurita, Sena; Miyamoto, Ryo; Tani, Hiroyuki; Tamura, Kyoichi; Bonkobara, Makoto

    2017-10-01

    Overexpression of KIT is one of the mechanisms that contributes to imatinib resistance in KIT mutation-driven tumors. Here, the mechanism underlying this overexpression of KIT was investigated using an imatinib-sensitive canine mast cell tumor (MCT) line CoMS, which has an activating mutation in KIT exon 11. A KIT-overexpressing imatinib-resistant subline, rCoMS1, was generated from CoMS cells by their continuous exposure to increasing concentrations of imatinib. Neither a secondary mutation nor upregulated transcription of KIT was detected in rCoMS1 cells. A decrease in KIT ubiquitination, a prolonged KIT life-span, and KIT overexpression were found in rCoMS1 cells. These events were suppressed by withdrawal of imatinib and were re-induced by re‑treatment with imatinib. These findings suggest that imatinib elicited overexpression of KIT via suppression of its ubiquitination. These results also indicated that imatinib-induced overexpression of KIT in rCoMS1 cells was not a permanently acquired feature but was a reversible response of the cells. Moreover, the pan deubiquitinating enzyme inhibitor PR619 prevented imatinib induction of KIT overexpression, suggesting that the imatinib-induced decrease in KIT ubiquitination could be mediated by upregulation and/or activation of deubiquitinating enzyme(s). It may be possible that a similar mechanism of KIT overexpression underlies the acquisition of imatinib resistance in some human tumors that are driven by KIT mutation.

  16. The Winfrith lecturers' demonstration kits for radiation and radioactivity

    International Nuclear Information System (INIS)

    Woffinden, G.B.

    1981-01-01

    During the early part of the 1970s a need arose for suitable aids to assist lecturers in giving talks on radioactivity and radiation to employees and occasionally to science students in local schools and colleges. A kit capable of demonstrating the basic properties of alpha, beta and gamma radiation was assembled for these purposes. During the latter half of the decade a demand arose for talks to non-scientific groups of the general public on nuclear power and radiation and some of the items in the original demonstration kit were found to be appropriate for these talks. The items used, now constitute the Basic Demonstration Kit. Meanwhile, a few changes or additions were made to the original kit which is now known as the Comprehensive Demonstration Kit. (author)

  17. Iodine-125--digoxin radioimmunoassay: comparison of commercial kits

    International Nuclear Information System (INIS)

    Battaglia, D.J.; Cianci, M.L.

    1976-01-01

    Iodine-125-digoxin radioimmunoassay kits available from Abbott Diagnostics (AD), Dade Division (D), Schwarz/Mann (SM), and Clinical Assays (CA) were evaluated with respect to assay quality. The kit accuracies did not differ significantly at 2.0 ng/ml and the interassay coefficients of variation ranged from 9 percent (AD) to 21.4 percent (CA). The accuracy for all kits above 4 ng/ml is questionable, and since serum-dilution values correlated well with undiluted serum values, the dilution method of dose quantitation is preferable for levels above 4 ng/ml. Although all the kits were adequate for evaluating digoxin at the 2 ng/ml level, the Abbott kit seems to be of slightly better quality

  18. A Tale of Two Space Rocks

    Science.gov (United States)

    Stephens, Robert; Megna, Ralph

    We review the results from two transient event observation projects undertaken by members of the Riverside Astronomical Society that were conducted in part from the Goat Mountain Astronomical Research Station near Landers, California. In the first instance, a meteor camera monitored the 2009 Geminid meteor shower and triangulated a bright bolide over the Los Angeles basin. In 2010 April, members participated in a campaign to observe the occultation of Zeta Ophiuchi by the asteroid 824 Anastasia.

  19. Toward a VPH/Physiome ToolKit.

    Science.gov (United States)

    Garny, Alan; Cooper, Jonathan; Hunter, Peter J

    2010-01-01

    The Physiome Project was officially launched in 1997 and has since brought together teams from around the world to work on the development of a computational framework for the modeling of the human body. At the European level, this effort is focused around patient-specific solutions and is known as the Virtual Physiological Human (VPH) Initiative.Such modeling is both multiscale (in space and time) and multiphysics. This, therefore, requires careful interaction and collaboration between the teams involved in the VPH/Physiome effort, if we are to produce computer models that are not only quantitative, but also integrative and predictive.In that context, several technologies and solutions are already available, developed both by groups involved in the VPH/Physiome effort, and by others. They address areas such as data handling/fusion, markup languages, model repositories, ontologies, tools (for simulation, imaging, data fitting, etc.), as well as grid, middleware, and workflow.Here, we provide an overview of resources that should be considered for inclusion in the VPH/Physiome ToolKit (i.e., the set of tools that addresses the needs and requirements of the Physiome Project and VPH Initiative) and discuss some of the challenges that we are still facing.

  20. Dumpster Optics: teaching and learning optics without a kit

    Science.gov (United States)

    Donnelly, Judy; Magnani, Nancy; Robinson, Kathleen

    2016-09-01

    The Next Generation Science Standards (NGSS) and renewed emphasis on STEM education in the U.S. have resulted in the development of many educational kits for teaching science in general and optics in particular. Many teachers do not have funding to purchase kits and practical experience has shown that even costly kits can have poorly written and misleading instructions and may include experiments that would not work in a classroom. Dumpster Optics lessons are designed to use inexpensive, commonly found materials. All lessons have been field-tested with students. We will describe the development of the lessons, provide examples of field testing experiences and outline possible future activities.

  1. Liquid kit for preparation of {sup 188}rhenium-etidronate

    Energy Technology Data Exchange (ETDEWEB)

    Marczewski, Barbara; Dias, Carla Roberta; Moraes, Vanessa; Osso Junior, Joao Alberto [Instituto de Pesquisas Energeticas e Nucleares (IPEN-CNEN/SP), SP (Brazil). Centro de Radiofarmacia]. E-mail: baszot@gmail.com

    2005-10-15

    The aim of this study was the preparation of a liquid kit for radiolabeling of {sup 188} Re-HEDP (hydroxyethylidene diphosphonate). {sup 188} Re was obtained from alumina based {sup 188} W/{sup 188} Re generators. This paper reports the efficacy of a cold kit stored for more than two weeks, determined by the dependence of the radiolabeling yields of {sup 188} Re-HEDP on the incubation time, reducing agent concentration, the effects of concentration of ligand, the p H of the reaction and the temperature. The cold kits showed a good stability when carrie-free rhenium-188 was added in the reaction mixture. (author)

  2. Liquid kit for preparation of 188rhenium-etidronate

    International Nuclear Information System (INIS)

    Marczewski, Barbara; Dias, Carla Roberta; Moraes, Vanessa; Osso Junior, Joao Alberto

    2005-01-01

    The aim of this study was the preparation of a liquid kit for radiolabeling of 188 Re-HEDP (hydroxyethylidene diphosphonate). 188 Re was obtained from alumina based 188 W/ 188 Re generators. This paper reports the efficacy of a cold kit stored for more than two weeks, determined by the dependence of the radiolabeling yields of 188 Re-HEDP on the incubation time, reducing agent concentration, the effects of concentration of ligand, the p H of the reaction and the temperature. The cold kits showed a good stability when carrie-free rhenium-188 was added in the reaction mixture. (author)

  3. Space space space

    CERN Document Server

    Trembach, Vera

    2014-01-01

    Space is an introduction to the mysteries of the Universe. Included are Task Cards for independent learning, Journal Word Cards for creative writing, and Hands-On Activities for reinforcing skills in Math and Language Arts. Space is a perfect introduction to further research of the Solar System.

  4. Rock Cycle Roulette.

    Science.gov (United States)

    Schmidt, Stan M.; Palmer, Courtney

    2000-01-01

    Introduces an activity on the rock cycle. Sets 11 stages representing the transitions of an earth material in the rock cycle. Builds six-sided die for each station, and students move to the stations depending on the rolling side of the die. Evaluates students by discussing several questions in the classroom. Provides instructional information for…

  5. THM-coupled modeling of selected processes in argillaceous rock relevant to rock mechanics

    International Nuclear Information System (INIS)

    Czaikowski, Oliver

    2012-01-01

    Scientific investigations in European countries other than Germany concentrate not only on granite formations (Switzerland, Sweden) but also on argillaceous rock formations (France, Switzerland, Belgium) to assess their suitability as host and barrier rock for the final storage of radioactive waste. In Germany, rock salt has been under thorough study as a host rock over the past few decades. According to a study by the German Federal Institute for Geosciences and Natural Resources, however, not only salt deposits but also argillaceous rock deposits are available at relevant depths and of extensions in space which make final storage of high-level radioactive waste basically possible in Germany. Equally qualified findings about the suitability/unsuitability of non-saline rock formations require fundamental studies to be conducted nationally because of the comparatively low level of knowledge. The article presents basic analyses of coupled mechanical and hydraulic properties of argillaceous rock formations as host rock for a repository. The interaction of various processes is explained on the basis of knowledge derived from laboratory studies, and open problems are deduced. For modeling coupled processes, a simplified analytical computation method is proposed and compared with the results of numerical simulations, and the limits to its application are outlined. (orig.)

  6. Math Description Engine Software Development Kit

    Science.gov (United States)

    Shelton, Robert O.; Smith, Stephanie L.; Dexter, Dan E.; Hodgson, Terry R.

    2010-01-01

    The Math Description Engine Software Development Kit (MDE SDK) can be used by software developers to make computer-rendered graphs more accessible to blind and visually-impaired users. The MDE SDK generates alternative graph descriptions in two forms: textual descriptions and non-verbal sound renderings, or sonification. It also enables display of an animated trace of a graph sonification on a visual graph component, with color and line-thickness options for users having low vision or color-related impairments. A set of accessible graphical user interface widgets is provided for operation by end users and for control of accessible graph displays. Version 1.0 of the MDE SDK generates text descriptions for 2D graphs commonly seen in math and science curriculum (and practice). The mathematically rich text descriptions can also serve as a virtual math and science assistant for blind and sighted users, making graphs more accessible for everyone. The MDE SDK has a simple application programming interface (API) that makes it easy for programmers and Web-site developers to make graphs accessible with just a few lines of code. The source code is written in Java for cross-platform compatibility and to take advantage of Java s built-in support for building accessible software application interfaces. Compiled-library and NASA Open Source versions are available with API documentation and Programmer s Guide at http:/ / prim e.jsc.n asa. gov.

  7. A least-squares computational ''tool kit''

    International Nuclear Information System (INIS)

    Smith, D.L.

    1993-04-01

    The information assembled in this report is intended to offer a useful computational ''tool kit'' to individuals who are interested in a variety of practical applications for the least-squares method of parameter estimation. The fundamental principles of Bayesian analysis are outlined first and these are applied to development of both the simple and the generalized least-squares conditions. Formal solutions that satisfy these conditions are given subsequently. Their application to both linear and non-linear problems is described in detail. Numerical procedures required to implement these formal solutions are discussed and two utility computer algorithms are offered for this purpose (codes LSIOD and GLSIOD written in FORTRAN). Some simple, easily understood examples are included to illustrate the use of these algorithms. Several related topics are then addressed, including the generation of covariance matrices, the role of iteration in applications of least-squares procedures, the effects of numerical precision and an approach that can be pursued in developing data analysis packages that are directed toward special applications

  8. Kit systems for granulated decontamination formulations

    Science.gov (United States)

    Tucker, Mark D.

    2010-07-06

    A decontamination formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents, and toxic industrial chemicals. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack, and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The formulation includes at least one solubilizing agent, a reactive compound, a sorbent additive, and water. A highly adsorbent sorbent additive (e.g., amorphous silica, sorbitol, mannitol, etc.) is used to "dry out" one or more liquid ingredients into a dry, free-flowing powder that has an extended shelf life, and is more convenient to handle and mix in the field. The formulation can be pre-mixed and pre-packaged as a multi-part kit system, where one or more of the parts are packaged in a powdered, granulated form for ease of handling and mixing in the field.

  9. A simple kit for rapid field diagnosis of potato virus Y by latex serological test

    Directory of Open Access Journals (Sweden)

    Aarne Kurppa

    1987-07-01

    Full Text Available A simple kit for rapid detection of potato virus Y by latex serological test was developed. The test is carried out on a white cardboard sheet and the results can be read by naked eye in two minutes. A test card of 10 x 6 cm holds latex sensitized antibodies, buffers and other necessary ingredients as dry blue colored formulate on the ringed areas of the card. A test card includes space for six tests and positive and negative controls. The kit also includes disposable plastic sticks for mixing the samples with test reagents and a hand press with disposable plastic tips. For testing, dried reagents are dissolved in drops of sample and mixed. After gentle rotation, samples containing virus appear clearly granulated while samples from healthy plants remain unagglutinated. The testing of undiluted extracts of evenly developed tuber sprouts resulted in over 91 % identity with the results obtained with ELISA that was used as a control method. Testing of diluted leaf extracts reached the same reliability but undiluted leaf extracts from glasshouse grown potatoes were not well suitable as test samples because of their dark green color. No such problems occurred with field grown material and a complete identity with the ELISA readings was true when the samples included secondarily infected potato plants. No reaction to other potato viruses than PVY was obtained by the test kit.

  10. EL PROYECTO ARKIT. LA VIVIENDA COMO KIT DE MUEBLES / Project Arkit. The home as a furniture kit

    Directory of Open Access Journals (Sweden)

    Francisco Javier Terrados Cepeda

    2012-05-01

    Full Text Available RESUMEN El artículo hace una revisión sintética sobre algunas de las bases conceptuales del llamado “proyecto Arkit” así como sobre sus resultados en forma de proyectos residenciales y construcciones reales. Una primera parte recorre ejemplos de vivienda moderna donde lo que entendemos como mueble, levemente agigantado de escala, ha definido y en algunos casos realmente construido casi con exclusividad el espacio doméstico. Son los “muebles que construyen casas”. En la segunda parte, el artículo reseña los seis proyectos de casas prefabricadas ligeras que se han concebido al amparo del concepto del “kit de muebles” como sistema de prefabricación abierta: las viviendas del CSCAE, el prototipo Campohermoso, el proyecto Arkit, la residencia de Tariquejo, el proyecto Solarkit y el proyecto Arkit 18, de los cuales han sido construidos y analizados el tercero y el quinto: Arkit y su variante con energía solar Solarkit. El proyecto Arkit es una aportación novedosa en el campo de la vivienda prefabricada ligera, adaptada a las condiciones ambientales del sur de Europa, que usa como elementos constitutivos piezas de escala intermedia que están a medio camino entre el tamaño y la versatilidad del mobiliario y la escala de la habitación convencional. El proyecto Arkit permite disposiciones a elección del usuario y, como muestran los ejemplos expuestos, adaptaciones a diferentes programas residenciales. SUMMARY The article makes a summary review of some of the conceptual bases of the “ArtKit project” and their results as housing projects and real buildings. The first part covers examples of modern homes where what we understand as furniture, now rather gigantic in scale, has defined, and in some cases almost exclusively built, the domestic space. This is the “furniture which builds houses”. In the second part, the article reviews the six light prefabricated housing projects that have been designed under the “kit

  11. Indoor Air Quality Tools for Schools Action Kit

    Science.gov (United States)

    The IAQ Tools for Schools Action Kit provides schools with information on how to carry out a practical plan to improve indoor air problems at little- or no-cost using straightforward activities and in-house staff.

  12. Autometallography: tissue metals demonstrated by a silver enhancement kit

    DEFF Research Database (Denmark)

    Danscher, G; Nørgaard, J O; Baatrup, E

    1987-01-01

    , primarily intended for the amplification of colloidal gold particles, has been used to demonstrate these catalytic tissue metals. Sections from animals exposed intravitally to aurothiomalatate, silver lactate, mercury chloride, sodium selenite or perfused with sodium sulphide were subjected to a commercial......In biological tissue, minute accumulations of gold, silver, mercury and zinc can be visualized by a technique whereby metallic silver is precipitated on tiny accumulations of the two noble metals, or on selenites or sulphides of all four metals. In the present study a silver enhancement kit...... silver enhancement kit (IntenSE, Janssen Pharmaceutica). It was found that the kit performs adequately to the silver lactate gum arabic developer and to the photographic emulsion technique. The kit can be used as a silver enhancement medium for the demonstration of zinc by the Neo-Timm and selenium...

  13. New RIA kit for determination of progesterone in cow milk

    International Nuclear Information System (INIS)

    Byszewska-Szpocinska, E.; Markiewicz, A.

    2006-01-01

    The determination of progesterone concentration in whole and fat-free milk 19-24 days after conception enables to distinguish fertile and non-fertile insemination, which is important in cattle breeding. The aim of this work was to develop a simple and quick radioimmunoassay test for the determination of progesterone in cow milk. Two types of solid-phase tubes coated with specific polyclonal anti-progesterone antibody from ORION Diagnostica and BIOSOURCE International, two different progesterone derivatives viz. progesterone-3- carboxymethyl oxime (CMO) and progesterone-11α-hemisuccinate (HS) conjugated to 125 I-histamine and the HPLC system with Lichrospher RP-18 column along with 65% acetonitrile/water as eluent to purify the tracers were used to carry out this work. Progesterone-3CMO- 125 I-histamine had a retention time of 13.2 min and progesterone-11α-hemisuccinate- 125 I-histamine had a retention time of 7.8 min. Two kinds of kits (kit I and kit II) were prepared, first with progesterone-3CMO- 125 I-histamine as the tracer and coated tubes from Progesterone Veterinary RIA kit of ORION Diagnostica and the second with progesterone-11αHS- 125 I-histamine as the tracer and coated tubes from Progesterone Veterinary RIA kit from BIOSOURCE International. Progesterone from Sigma and selected fat-free cow's milk without progesterone as zero progesterone milk matrix were used for standard preparation. The optimal assay procedure was as follows: 50μL standards, controls and fat-free milk samples were pipetted into coated tubes followed by addition of 500μL of diluted tracer. The tubes were incubated for 2h in case of kit I and 3h for kit II at RT. After the incubation, the tubes were decanted and counted. The assay range was 0 to 270 nmol/L for kit I and 0 to 300 nmol/L for kit II. The sensitivity of the kit with ORION coated tubes was better (0.8 nmol/L) than that of BIOSOURCE tubes which was 1.5 nmol/L. Validation of these assays in terms of specificity, accuracy

  14. Quality control for a group of pyrophosphate-Sn kits

    International Nuclear Information System (INIS)

    Isaac, M.; Gamboa, R.; Hernandez, I.; Leyva, R.; Turino, D.

    1994-01-01

    The quality control for a group of Pyrophosphate-Sn kits for labeling with 99 m Tc is carry out at the Isotope Center. A general discussion takes place about the instrumental techniques for the determination of the kit constituent such as ligands, Sn(II), water, etc, as well as the control table for the evaluation of the warranty time. (author). 5 refs, 4 figs

  15. Android: Call C Functions with the Native Development Kit (NDK)

    Science.gov (United States)

    2016-09-01

    from a Java application. 15. SUBJECT TERMS Android , NDK, Native Development Kit, C callable, Java Native Interface, JNI, Java, C/C++ 16. SECURITY ...ARL-TN-0782 ● SEP 2016 US Army Research Laboratory Android : Call C Functions with the Native Development Kit (NDK) by Hao Q...Do not return it to the originator. ARL-TN-0782 ● SEP 2016 US Army Research Laboratory Android : Call C Functions with the Native

  16. Manipulating the Toughness of Rocks through Electric Potentials

    Data.gov (United States)

    National Aeronautics and Space Administration — When rocks are stressed, electronic charge carriers are activated which are defect electrons in the oxygen anion sublattice, O– in a matrix of O2–, known as positive...

  17. Rock glaciers, Fletschhorn Area, Valais, Switzerland, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains a total amount of 74 rock glaciers which were investigated in the Fletschhorn Area in the southern Swiss Alps during the summer of 1995. The...

  18. The Rock that Hit New York

    Energy Technology Data Exchange (ETDEWEB)

    Meade, Roger Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Keksis, August Lawrence [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-03

    On January 12, 1975, a rock seemed to fall from the sky over New York State’s Schoharie County hitting the tractor of a local farmer, who was “preparing his fields for spring planting.” As the farmer later described the event to a reporter from the UFO INVESTIGATOR, the object glanced off the tractor, fell to the ground, and melted its way through a patch of ice that was two and one half inches thick. The farmer, Leonard Tillapaugh, called the county sheriff, Harvey Stoddard, who recovered the rock, noting that it “was still warm.” Why and how a sample of the rock came to Los Alamos is not known. However, it captivated a wide Laboratory audience, was subjected to rigorous testing and evaluation. Los Alamos used the scientific method in the manner promoted by Hynek. Did Los Alamos solve the mystery of the rock’s origin? Not definitively. Although the exact origin could not be determined, it was shown conclusively that the rock was not from outer space. With that said, the saga of Rock that hit New York came to an end. Nothing more was said or written about it. The principals involved have long since passed from the scene. The NICAP ceased operations in 1980. And, the rock, itself, has disappeared.

  19. Investigation of the porosity of rocks

    International Nuclear Information System (INIS)

    Hellmuth, K.H.; Siitari-Kauppi, M.

    1990-06-01

    Methods for characterizing the nature of rock porosity in conjunction with diffusion experiments, are amongst the primary tools used in repository-site selection investigations. At this time no experimental method, alone, is capable of giving an unambiguous picture of the narrow-aperture pore space in crystalline rock. Methods giving information on overall properties must be complemented by those having high spatial resolution; then the lateral distribution of porosity within the matrix and its association with particular mineral phases or features, such as microfissures, fissure fillings, weathered or altered mineral phases etc, and the identification of diffusion pathways in inhomogeneous rock matrices can be determined. Nonsorbing, nonelectrolytic tracers should be used when one wants to determine rock-typical properties of the internal porosity without interference of interactions with surfaces. Preliminary information on a new method fulfilling these criteria is given. Impregnating rock samples with methylmethacrylate labeled with carbon-14 which, after impregnation, was polymerized by gamma radiation, gave specimens that made preparation of sections suitable for quantification by autoradiographic methods easy. Diffusion experiments can be conducted so that labeled MMA diffuses out of rock specimens into inactive free, MMA. Additional information may be gained by leaching PMMA fractions of lower molecular weight from the matrix

  20. Evaluation of the Coca-Cola company travel health kit.

    Science.gov (United States)

    Harper, Lynne A; Bettinger, Julie; Dismukes, Roberta; Kozarsky, Phyllis E

    2002-01-01

    The Coca-Cola travel health kit has been used for about one decade for international travelers and required evaluation to see if the items contained were appropriate for the employees. Two hundred thirty-four travelers were sampled and filled out a voluntary survey including questions about demographic information, travel history, and usage and value of the contents of the travel health kit. One hundred eighty-one surveys were returned; 65% of the respondents were male, and the majority of travelers were between the ages of 36 and 45 years. The most useful items were analgesics and medications used for gastrointestinal problems. In general, the items identified as being the least useful were those requiring specialized use by a medical practitioner, such as needles and syringes. Suggestions of items to be added to the kit included vitamins, cough drops, sleep aids, and eye drops. A surprising result that Coca-Cola employees expressed the desire for brand name rather than generic items. Evaluation of the Coca-Cola Company travel health kit revealed it to be very useful to most corporate travelers. Suggestions that were made will be taken into consideration in designing a new kit, and consideration is being given to whether a basic travel health kit should be provided to which travelers can add other items depending on their personal needs.

  1. Usefulness of CA 130 kit based on IRMA

    International Nuclear Information System (INIS)

    Fujii, Takashi; Kimura, Yoshiko; Ata, Mariko; Miyagawa, Naoko; Iio, Atsushi; Hamamoto, Ken

    1988-01-01

    Immunoradiometric assay for CA 130 was fundamentally and clinically evaluated using a commercially available D-7111 kit. Incubation time was 4 hr with the present CA 133 kit as compared with 16 - 24 hr with conventional CA 125 kit. Laboratory performance of CA 130 kit was satisfactory for standard curve, reproducibility, and recovery test. There was well correlation between the present CA 130 kit and CA 125 kit (r = 0.931). The concentration of CA 130 in the serum was significantly higher in healthy women than men (17.3 +- 10.5 U/ml vs 9.6 +- 5.1 U/ml). Serum CA 130 levels tended to decrease with aging, regardless of sex. These levels were changeable with menstrual cycle ; i.e., these were significantly higher during menstrual phase (24.2 +- 9.0 U/ml) and significantly lower during ovulatory phase (10.9 +- 2.4 U/ml) and during menopause (12.1 +- 3.4 U/ml). Cut off serum CA 130 levels were defined as 20 U/ml for men and 38 U/ml for women. Positive rate for CA 130 was the highest in cases of ovarian cancer (80 %), followed by endometrial cancer (50 %), pancreatic cancer (47 %), benign ovarian tumor (44 %), and lung cancer (39 %). (Namekawa, K.)

  2. C-kit expression in canine mucosal melanomas.

    Science.gov (United States)

    Newman, S J; Jankovsky, J M; Rohrbach, B W; LeBlanc, A K

    2012-09-01

    The c-kit receptor is responsible for transmission of promigration signals to melanocytes; its downregulation may be involved in malignant progression of human melanocytic neoplasms. Expression of this receptor has not been examined in normal or neoplastic melanocytes from dogs. In this study, 14 benign dermal and 61 malignant mucosal melanocytic tumors were examined for c-kit (KIT) expression. Sites of the mucosal melanomas were gingiva (not further specified; n = 30), buccal gingiva (n = 6), soft palate (n = 4), hard palate (n = 5), tongue (n = 7), lip (n = 6), and conjunctiva (n = 3). Melan A was expressed in all 14 dermal melanocytomas and in 59 of 61 (96.7%) tumors from oral or conjunctival mucosa, confirming melanocytic origin. C-kit receptor expression was strong and diffuse throughout the cytoplasm in all 14 dermal melanocytomas and was identified in basilar mucosal melanocytes over submucosal neoplasms (27 of 61, 44.3%), junctional (neoplastic) melanocytes (17 of 61, 27.9%), and, less commonly, neoplastic melanocytes of the subepithelial tumors (6 of 61, 9.8%). KIT expression anywhere within the resected melanomas correlated with significantly longer survival. These results suggest that c-kit receptor expression may be altered in canine melanomas and may have potential as a prognostic indicator for mucosal melanomas.

  3. Direct assay for urine cortisol with cortisol kit TFB

    Energy Technology Data Exchange (ETDEWEB)

    Manaka, Yukiko; Watanabe, Michiko; Hosoya, Takaaki [Yamagata Univ. (Japan). Hospital

    2002-05-01

    We examined Cortisol Kit TFB for direct assay of urine cortisol. And the multiplication by dilution factor of urine cortisol values in this kit was examined. The coefficient of correlation of cortisol levels (46 urine samples) between Cortisol Kit TFB and Chemilumi ACS-Cortisol II, which is another kit for direct assay of urine cortisol, was r=0.858, y=1.86x+38.2 (p<0.001). There were differences between the both cortisol levels of each urine sample in spite of the good coefficient of correlation. The urine cortisol values obtained from the standard curve in addition of 50 {mu}l of zero standard were 50-80% of the values obtained from the standard curve in the package insert. These results suggest that the specificity of the antibodies of both direct assay kits for urine cortisol may be different each other, and the multiplication by 1.09, the dilution factor due to the addition of zero standard to only urine sample, is unnecessary although it is indispensable for urine samples to add zero standard. Cortisol Kit TFB was very convenient for its easy assay procedure and short incubation. (author)

  4. Direct assay for urine cortisol with cortisol kit TFB

    International Nuclear Information System (INIS)

    Manaka, Yukiko; Watanabe, Michiko; Hosoya, Takaaki

    2002-01-01

    We examined Cortisol Kit TFB for direct assay of urine cortisol. And the multiplication by dilution factor of urine cortisol values in this kit was examined. The coefficient of correlation of cortisol levels (46 urine samples) between Cortisol Kit TFB and Chemilumi ACS-Cortisol II, which is another kit for direct assay of urine cortisol, was r=0.858, y=1.86x+38.2 (p<0.001). There were differences between the both cortisol levels of each urine sample in spite of the good coefficient of correlation. The urine cortisol values obtained from the standard curve in addition of 50 μl of zero standard were 50-80% of the values obtained from the standard curve in the package insert. These results suggest that the specificity of the antibodies of both direct assay kits for urine cortisol may be different each other, and the multiplication by 1.09, the dilution factor due to the addition of zero standard to only urine sample, is unnecessary although it is indispensable for urine samples to add zero standard. Cortisol Kit TFB was very convenient for its easy assay procedure and short incubation. (author)

  5. Eos Chaos Rocks

    Science.gov (United States)

    2006-01-01

    11 January 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows light-toned, layered rock outcrops in Eos Chaos, located near the east end of the Valles Marineris trough system. The outcrops occur in the form of a distinct, circular butte (upper half of image) and a high slope (lower half of image). The rocks might be sedimentary rocks, similar to those found elsewhere exposed in the Valles Marineris system and the chaotic terrain to the east of the region. Location near: 12.9oS, 49.5oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Southern Summer

  6. Remarks on some rock neutron parameters

    International Nuclear Information System (INIS)

    Czubek, J.A.

    1984-01-01

    A method to calculate the thermal neutron parameters of rocks is given in the paper. It is based on a proper energy averaging of cross-sections for all rock matrix and rock saturating liquid constituents. The diffusion lengths in different lithologies in function of the variable rock porosity have been calculated. An influence of the thermal neutron spectrum on the shape of the porosity calibration curves for the dual spacing neutron method is shown. Magmatic rocks as a possible source of geothermal energy are now becoming a target of neutron loggings for the porosity determination. Here the knowledge of the slowing-down lengths is of great importance in the problem of the estimation of the calibration curves. A semi-analytical approach to get this parameter is given in the paper. It was found, as far as concerns the slowing-down of fast neutrons, that all magmatic rocks behave as sandstone with, however, different content of bound water in the rock matrix and different rock matrix density. Some neutron methods are based on the detection of epithermal neutrons. For theoretical considerations it is important to know the physical meaning of the registered signal. From the discussion of experimental data reported in the literature it seems that it is the slowing-down density that is the physical quantity being measured. This conclusion has a very important practical implication - the porosity calibration curves depend upon the slowing-down length alone and are independent of the slowing-down cross-section for epithermal neutrons

  7. Digital Rock Studies of Tight Porous Media

    Energy Technology Data Exchange (ETDEWEB)

    Silin, Dmitriy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-08-07

    This technical report summarizes some recently developed approaches to studies of rock properties at a pore scale. Digital rock approach is complementary to laboratory and field studies. It can be especially helpful in situations where experimental data are uncertain, or are difficult or impossible to obtain. Digitized binary images of the pore geometries of natural rocks obtained by different imaging techniques are the input data. Computer-generated models of natural rocks can be used instead of images in a case where microtomography data are unavailable, or the resolution of the tools is insufficient to adequately characterize the features of interest. Simulations of creeping viscous flow in pores produce estimates of Darcy permeability. Maximal Inscribed Spheres calculations estimate two-phase fluid distribution in capillary equilibrium. A combination of both produce relative permeability curves. Computer-generated rock models were employed to study two-phase properties of fractured rocks, or tight sands with slit-like pores, too narrow to be characterized with micro-tomography. Various scenarios can simulate different fluid displacement mechanisms, from piston-like drainage to liquid dropout at the dew point. A finite differences discretization of Stokes equation is developed to simulate flow in the pore space of natural rocks. The numerical schemes are capable to handle both no-slip and slippage flows. An upscaling procedure estimates the permeability by subsampling a large data set. Capillary equilibrium and capillary pressure curves are efficiently estimated with the method of maximal inscribed spheres both an arbitrary contact angle. The algorithms can handle gigobytes of data on a desktop workstation. Customized QuickHull algorithms model natural rocks. Capillary pressure curves evaluated from computer-generated images mimic those obtained for microtomography data.

  8. Rock Moved by Mars Lander Arm

    Science.gov (United States)

    2008-01-01

    The robotic arm on NASA's Phoenix Mars Lander slid a rock out of the way during the mission's 117th Martian day (Sept. 22, 2008) to gain access to soil that had been underneath the rock.The lander's Surface Stereo Imager took the two images for this stereo view later the same day, showing the rock, called 'Headless,' after the arm pushed it about 40 centimeters (16 inches) from its previous location. 'The rock ended up exactly where we intended it to,' said Matt Robinson of NASA's Jet Propulsion Laboratory, robotic arm flight software lead for the Phoenix team. The arm had enlarged the trench near Headless two days earlier in preparation for sliding the rock into the trench. The trench was dug to about 3 centimeters (1.2 inches) deep. The ground surface between the rock's prior position and the lip of the trench had a slope of about 3 degrees downward toward the trench. Headless is about the size and shape of a VHS videotape. The Phoenix science team sought to move the rock in order to study the soil and the depth to subsurface ice underneath where the rock had been. This image was taken at about 12:30 p.m., local solar time on Mars. The view is to the north northeast of the lander. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by JPL, Pasadena, Calif. Spacecraft development was by Lockheed Martin Space Systems, Denver.

  9. Current results of an arachnological survey of some sandstone rock sites in Bohemia (so-called "rock cities"

    Directory of Open Access Journals (Sweden)

    Růžička, Vlastimil

    1992-07-01

    Full Text Available The spider fauna of the Adrspach-Teplice rockswas investigated. Some records on spider fauna of other nine sandstone rock areas are included. The phenomenon of "rock cities" manifests itself in three aspects: (1 In the bottom parts are microclimatically cold spaces, frequently hosting northern ot mountain species of invertebrates, which here have an azonal occurence. (2 the sun exposed tops of rocks can host thermophilous species. (3 Some species are limited to the surface of rocks and boulders. These are referred to as lithophilous or lithobiont species.

  10. Supply kits for antenatal and childbirth care: a systematic review.

    Science.gov (United States)

    Aleman, Alicia; Tomasso, Giselle; Cafferata, María Luisa; Colomar, Mercedes; Betran, Ana Pilar

    2017-12-13

    It is critical to increase the uptake of interventions proven to be effective to improve maternal and perinatal outcomes. Supply kits have been suggested to be a feasible strategy designed to ensure timely availability and effective follow-up of care. We conducted a systematic review to summarize the evidence on the uptake, effectiveness and safety of supply kits for maternal care. MEDLINE, the Cochrane Pregnancy and Childbirth Group's Trials Register, Campbell Collaboration, Lilacs, Embase and unpublished studies were searched. Studies that reported the efficacy, safety and use of supply kits for maternal healthcare were eligible. Participants were pregnant women or in childbirth. Supply kits were defined as a collection of medicines, supplies or instruments packaged together with the aim of conducting a healthcare task. Two reviewers independently performed the screening, data extraction, and methodological and quality assessment. 24 studies were included: 4 of them were systematic reviews and 20 primary studies. Eighteen studies evaluated a so-called "clean delivery kit". In all but two studies, the kits were used by more than half of the participants. A meta-analysis was deemed inappropriate due to the heterogeneity in study design, in the components of the interventions implemented, in the content of the kits, and in outcomes. Nine studies assessed neonatal outcomes and found statistically significant reductions in cord infection, sepsis and tetanus-related mortality in the intervention group. Three studies showed evidence of reduced neonatal mortality (OR 0.52, 0.60 and 0.71) with statistically significant confidence intervals in all cases. Four studies reported odd ratios for maternal mortality, but only one showed evidence of a statistically significant decrease in this outcome but it was ascribed to hand washing prior to childbirth and not with the use of kits. This review suggests potential benefits in the use of supply kits to improve maternal and

  11. Rock properties data base

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, R.; Gorski, B.; Gyenge, M.

    1991-03-01

    As mining companies proceed deeper and into areas whose stability is threatened by high and complex stress fields, the science of rock mechanics becomes invaluable in designing underground mine strata control programs. CANMET's Mining Research Laboratories division has compiled a summary of pre- and post-failure mechanical properties of rock types which were tested to provide design data. The 'Rock Properties Data Base' presents the results of these tests, and includes many rock types typical of Canadian mine environments. The data base also contains 'm' and 's' values determined using Hoek and Brown's failure criteria for both pre- and post-failure conditions. 7 refs., 3 tabs., 9 figs., 1 append.

  12. Eclogite facies rocks

    National Research Council Canada - National Science Library

    Carswell, D. A

    1990-01-01

    ... of eclogite evolution and genesis. The authors present a thorough treatment of the stability relations and geochemistry of these rocks, their intimate association with continental plate collision zones and suture zones...

  13. Rock kinoekraanil / Katrin Rajasaare

    Index Scriptorium Estoniae

    Rajasaare, Katrin

    2008-01-01

    7.-11. juulini kinos Sõprus toimuval filminädalal "Rock On Screen" ekraanile jõudvatest rockmuusikuid portreteerivatest filmidest "Lou Reed's Berlin", "The Future Is Unwritten: Joe Strummer", "Control: Joy Division", "Hurriganes", "Shlaager"

  14. Eclogite facies rocks

    National Research Council Canada - National Science Library

    Carswell, D. A

    1990-01-01

    .... This is the first volume to provide a coherent and comprehensive review of the conditions necessary for the formation of eclogites and eclogite facies rocks and assemblages, and a detailed account...

  15. Solid as a rock

    International Nuclear Information System (INIS)

    Pincus, H.J.

    1984-01-01

    Recent technologic developments have required a more comprehensive approach to the behavior of rock mass or rock substance plus discontinuities than was adequate previously. This work considers the inherent problems in such operations as the storage of hot or cold fluids in caverns and aquifers, underground storage of nuclear waste, underground recovery of heat from hydrocarbon fuels, tertiary recovery of oil by thermal methods, rapid excavation of large openings at shallow to great depths and in hostile environments, and retrofitting of large structures built on or in rock. The standardization of methods for determining rock properties is essential to all of the activities described, for use not only in design and construction but also in site selection and post-construction monitoring. Development of such standards is seen as a multidisciplinary effort

  16. Rock Equity Holdings, LLC

    Science.gov (United States)

    The EPA is providing notice of an Administrative Penalty Assessment in the form of an Expedited Storm Water Settlement Agreement against Rock Equity Holdings, LLC, for alleged violations at The Cove at Kettlestone/98th Street Reconstruction located at 3015

  17. Pop & rock / Berk Vaher

    Index Scriptorium Estoniae

    Vaher, Berk, 1975-

    2001-01-01

    Uute heliplaatide Redman "Malpractice", Brian Eno & Peter Schwalm "Popstars", Clawfinger "A Whole Lot of Nothing", Dario G "In Full Color", MLTR e. Michael Learns To Rock "Blue Night" lühitutvustused

  18. Rock glaciers Gruben, Muragl and Murtel, Switzerland: Area-wide flow fields, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — Besides their thermal and mechanical properties, rock glaciers are essentially defined by their kinematics. Knowledge of the permafrost flow field provides important...

  19. Migration of radionuclides in fissured rock

    International Nuclear Information System (INIS)

    Neretnieks, I.

    1982-01-01

    Some computed results of radionuclide migration in fissured rock are presented. The computations are based on a model which describes flow as occurring in a multitude of independent fissures (stratified flow). This gives rise to strong dispersion of channeling. The radionuclide migration in the individual fissures is modelled by the advection equation on a parallel walled channel with porous walls. The nuclides may diffuse into the pores and sorb reversibly on the pore surfaces. The effluent rates of 23 important nuclides are presented as functions of distance and time for various of important parameters such as rock permeability, diffusion coefficients, release rates, time of first release, fissure spacing and fissure width distribution. (Author)

  20. Basic rocks in Finland

    International Nuclear Information System (INIS)

    Piirainen, T.; Gehoer, S.; Iljina, M.; Kaerki, A.; Paakkola, J.; Vuollo, J.

    1992-10-01

    Basic igneous rocks, containing less than 52% SiO 2 , constitute an important part of the Finnish Archaean and Proterozoic crust. In the Archaean crust exist two units which contain the majority of the basic rocks. The Arcaean basic rocks are metavolcanics and situated in the Greenstone Belts of Eastern Finland. They are divided into two units. The greenstones of the lower one are tholeiites, komatiites and basaltic komatiites. The upper consists of bimodal series of volcanics and the basic rocks of which are Fe-tholeiites, basaltic komatiites and komatiites. Proterozoic basic rocks are divided into seven groups according to their ages. The Proterozoic igneous activity started by the volominous basic magmatism 2.44 Ga ago. During this stage formed the layered intrusions and related dykes in the Northern Finland. 2.2 Ga old basic rocks are situated at the margins of Karelian formations. 2.1 Ga aged Fe-tholeiitic magmatic activity is widespread in Eastern and Northern Finland. The basic rocks of 1.97 Ga age group are met within the Karelian Schist Belts as obducted ophiolite complexes but they occur also as tholeiitic diabase dykes cutting the Karelian schists and Archean basement. The intrusions and the volcanics of the 1.9 Ga old basic igneous activity are mostly encountered around the Granitoid Complex of Central Finland. Subjotnian, 1.6 Ga aged tholeiitic diabases are situated around the Rapakivi massifs of Southern Finland, and postjotnian, 1.2 Ga diabases in Western Finland where they form dykes cutting Svecofennian rocks

  1. Iodobell in vivo kits for labelling with 123I or 131I

    International Nuclear Information System (INIS)

    Koernyei, J.; Horvath, M.; Pszota, A.; Lakatos, M.; Szirtes, L.

    1988-01-01

    Iodobell in vivo kits provide an easy and fast method for 'on the spot' radioiodination with 123 I (or 131 I). Until now three kits have been developed in the Institute of Isotopes Budapest, the heptadecanoic acid, the hippurate and the MIBG kits. From these, the heptadecanoic acid kit is being tested in humans in Hungary, the other two are under the registration procedure. The Iodobell in vivo kits may contribute to the application of 123 I radioisotope in Hungary. (orig.)

  2. Basic and clinical evaluation of thyroxine radioimmunoassay kit. I. T-4 RIA kit

    Energy Technology Data Exchange (ETDEWEB)

    Bunko, H; Hisada, K [Kanazawa Univ. (Japan). Hospital

    1976-02-01

    The T/sub 4/ RIA kit is based on single antibody radioimmunoassay and utilizes a resin-sponge to separate free T/sub 4/-/sup 125/I from the incubation mixture. The use of the sodium salt of trichloroacetic acid (TBG inhibitor) permits direct radioimmunoassay of T/sub 4/ without a tedious extraction procedure. The T/sub 4/ RIA kit needs only 0.05 ml of patient serum and one hour of incubation to measure T/sub 4/. The TBG inhibitior was equivalent to 5.1 ..mu..g% of T/sub 4/ in displacing radioactive T/sub 4/ from TBG in a CPBA(Res-O-Mat T/sub 4/) system, and the TBG inhibitor volume of 0.5 ml (ten times of serum) was needed to measure a high T/sub 4/ concentration serum. The change of incubation temperature was more affected on the standard curve than that of incubation time. Correlation of the T/sub 4/ value between radioimmunoassay and CPBA in 69 patients was good (r=0.88612, p<0.01) and showed a slightly higher T/sub 4/ value when measured with radioimmunoassay than CPBA (linear regression function: Y=1.17506 + 0.95766X). Correlation of T/sub 4/ between Compu-curve and conventional standard curve was excellent (r=0.9995), but a slight difference was found in both low and high T/sub 4/ concentrations. In euthyroid patients without thyroid diseases, T/sub 4/ concentration was 9.92 +- 2.66 (SD) ..mu..g% and the normal range was between 4.60 and 15.24 ..mu..g%. Reproducibility within assay was 9.9% (CV) and recovery rate was 70% when added 10 ..mu..g of T/sub 4/ and 86% when added 15 ..mu..g% of T/sub 4/. From these results, the authors concluded that radioimmunoassay of serum T/sub 4/ using the T/sub 4/ RIA kit would be a promising one, especially when measuring a large amount of samples per assays.

  3. Distribution and ultrastructure of interstitial cells of Cajal in the mouse colon, using antibodies to Kit and Kit(W-lacZ) mice

    DEFF Research Database (Denmark)

    Vanderwinden, J M; Rumessen, J J; Bernex, F

    2000-01-01

    kinase receptor Kit as a marker. Sections and whole mounts were studied by confocal microscopy after double immunofluorescence with specific antibodies. The ultrastructure of Kit-expressing cells was examined by electron microcopy in KitW-lacz/+ transgenic mice, which carry the lacz gene inserted...

  4. Tumor markers kits development for use in radioimmunometric assays

    International Nuclear Information System (INIS)

    Ahmed, B.

    1997-01-01

    The immunoassays such as RIA and IRMA are now widely used through the world for the quantitation of a variety of substances in the biological fluid for their high sensibility and specificity which required simple equipments. These techniques are also very used in Algeria for an effective amelioration of public heath The assays kits of RIA/IRMA of thyroid hormones are the most used, followed by peptidic hormones, steroids hormones and IRMA Tumor Markers (T.M) kits. In spite of the important demand, of tumor markers kits for the diagnosis and follow up of cancers their use are always insufficient due to the high cost. The research contract programme proposed by IAEA on the theme 'The Developments of IRMA Tumor Markers Kits' of prostate specific Antigen (PSA) and Tissue Polypeptide Specific Antigen (TPS) will allowed us to produce locally with best quality-price, the main reagents for PSA and TPS IRMA assays kits for diagnosis and follow up the prostate and breast cancers which are very spready in the country. This report include the following points: Generalities on the use of tumor markers in Algeria, programme for the Development of the PSA IRMA assay (schedule of protocols applied for each reagents; annual planning for assessing the programme activities) and conclusion

  5. Uji Stabilitas Kit Cair Tetrofosmin pada Berbagai Kondisi Penyimpanan

    Directory of Open Access Journals (Sweden)

    Yunilda Yunilda

    2016-09-01

    Full Text Available Tetrofosmin radiopharmaceutical compound that is being developed by PTRR BATAN for use as myocardial perfusion imaging agent and cancer diagnostic agent in nuclear medicine. The aim of this study is observe the stability of this liquid kits after stored in various condition to determine its expire date various condition. The stability test was done of 1 hour, 3 hours, 5 hours and 7 hours after labeling. The radiochemical was determined its radiochemical purity has to be ≥ 90 %. Analysis of radiochemical purity was carried out by separation method which using Sep-Pak C18 cartride. Storage condition of tetrofosmin kit was carried out at various temperatures as in the deep freezer (-800C, freezer (-180C, refrigerator (2-60C and cool box (2-60C. The result showed that the liquid tetrofosmin kits stored in deep freezer, freezer, refrigerator were stable up to 23 months, 8 weeks and 4 days respectively. Simulation of stability  test after stored in a cool box was done by observing the temperature of cool box, and the result showed that the temperature in the cool box was constant as in refrigerator for up to 24 hours. Tetrofosmin which has been labeled with technetium-99m can with stand up 7 hours. It is concluded that expiry date of liquid tetrofosmin kit related with storage temperature, the lower the temperature the longer the expiry date of the kits.

  6. Utilization of milk energy by suckling mink kits

    DEFF Research Database (Denmark)

    Tauson, Anne-Helene; Fink, Rikke; Hansen, Kirsten Bislev

    2004-01-01

    A total of 36 mink dams and their litters of 3, 6 or 9 kits were used for determination of milk intake of the suckling young by means of deuterium dilution technique, and chemical composition of milk and of kit bodies. Measurements were performed during lactation weeks 1-4, each week with 3 dams...... with each litter size. Milk intake was determined over a 48 h measurement period, and by the end of this milk samples were collected and 2 kits (litters of 6 and 9) or 1 kit per litter (litters of 3) were killed for body chemical composition. Based on the results, different models were applied...... for calculation of the energetic efficiency of milk. Dam milk yield increased steadily from week 1 until week 3 but only slightly from week 3 to 4. The increase declined with increasing litter size, and for dams suckling 9 kits the increment from week 3 to week 4 was only 2 g. The dry matter content of milk...

  7. Nociceptive tuning by stem cell factor/c-Kit signaling.

    Science.gov (United States)

    Milenkovic, Nevena; Frahm, Christina; Gassmann, Max; Griffel, Carola; Erdmann, Bettina; Birchmeier, Carmen; Lewin, Gary R; Garratt, Alistair N

    2007-12-06

    The molecular mechanisms regulating the sensitivity of sensory circuits to environmental stimuli are poorly understood. We demonstrate here a central role for stem cell factor (SCF) and its receptor, c-Kit, in tuning the responsiveness of sensory neurons to natural stimuli. Mice lacking SCF/c-Kit signaling displayed profound thermal hypoalgesia, attributable to a marked elevation in the thermal threshold and reduction in spiking rate of heat-sensitive nociceptors. Acute activation of c-Kit by its ligand, SCF, resulted in a reduced thermal threshold and potentiation of heat-activated currents in isolated small-diameter neurons and thermal hyperalgesia in mice. SCF-induced thermal hyperalgesia required the TRP family cation channel TRPV1. Lack of c-Kit signaling during development resulted in hypersensitivity of discrete mechanoreceptive neuronal subtypes. Thus, c-Kit can now be grouped with a small family of receptor tyrosine kinases, including c-Ret and TrkA, that control the transduction properties of sensory neurons.

  8. KiT: a MATLAB package for kinetochore tracking.

    Science.gov (United States)

    Armond, Jonathan W; Vladimirou, Elina; McAinsh, Andrew D; Burroughs, Nigel J

    2016-06-15

    During mitosis, chromosomes are attached to the mitotic spindle via large protein complexes called kinetochores. The motion of kinetochores throughout mitosis is intricate and automated quantitative tracking of their motion has already revealed many surprising facets of their behaviour. Here, we present 'KiT' (Kinetochore Tracking)-an easy-to-use, open-source software package for tracking kinetochores from live-cell fluorescent movies. KiT supports 2D, 3D and multi-colour movies, quantification of fluorescence, integrated deconvolution, parallel execution and multiple algorithms for particle localization. KiT is free, open-source software implemented in MATLAB and runs on all MATLAB supported platforms. KiT can be downloaded as a package from http://www.mechanochemistry.org/mcainsh/software.php The source repository is available at https://bitbucket.org/jarmond/kit and under continuing development. Supplementary data are available at Bioinformatics online. jonathan.armond@warwick.ac.uk. © The Author 2016. Published by Oxford University Press.

  9. Evaluation of Desensol As a Standard Patch Test Kit

    Directory of Open Access Journals (Sweden)

    K C Shah

    1987-01-01

    Full Text Available In a study undertaken to find out the usefulness of ′Desensol′ patch test kit to detect contact allergens, in 200 cases revealed 24 cases with negative patch test with all the antigens and 55 cases reacted to even the Vaseline control. -Excluding these 79 cases, the common contact allergens were potassium bichr6ma,te, (40.49%, TMTD(28.92%, PPD(24.79%, epoxy resin (23.14%, colophony (19.0%, nickel sulfate (19.0%, Framycetin (19.0% and nitrofurazone (19.0%. Desensol patch test kit is lacking in certain antigens while in our country due to varied environmental factors and social customs, a person is exposed to a large number of natural and man-made contact allergens. So usefulness of such a kit like. Desensol is limited.

  10. Nuclear track detector kit for use in teaching

    International Nuclear Information System (INIS)

    Medveczky, L.; Somogyi, G.

    1986-01-01

    By the use of solid state nuclear track detectors (SSNTDs) one may carry out several useful and impressive educational experiments and demonstrations to illustrate different phenomena when teaching of nuclear physics. Realizing this situation the authors have published, since 1970, reports on several experiments for teaching demonstrations. Based on the authors instructions, a factory in Hungary (TANFRT, National Manufacturers and Suppliers of School Equipment, Budapest) constructed a kit for the use of nuclear track detectors in teaching. The portable kit contains the following items: alpha-emitting weak sources, solid state nuclear track detectors (unirradiated, irradiated, unetched and etched sheets), simple tools for carrying out experiments (facilities for irradiation and etching, etc.), slides showing photos of typical etch-tracks of light and heavy nuclei, user manual. By the help of the kit both pupils and teachers can perform various useful experiments and/or demonstrations. (author)

  11. Development of RIA kits for tumor-markers monitoring

    International Nuclear Information System (INIS)

    Suprarop, P.

    1997-01-01

    All reagents for tumor markers assays are imported from various manufacturers mainly CIS bio international. The average cost of these reagents is ranged from 80-150 bath/test (2-4 dollars test). The screening test for cancers could not be done especially in other regions of Thailand whose budgets and resources are so limited. If the reagents are made locally, many laboratories can perform the tests and use as primary diagnosis, screening or monitor the course of the disease following treatment. In addition, these reagents could help clinicians and give complementary information on the tumor status to improve quality of life in Thailand. Research objectives include: 1. Development of IRMA reagent kits suitable for diagnosing staging and monitoring prostrate and breast cancer. 2. Transfer of technology and reagent kits to relevant laboratories in Thailand. 3. Routine distribution of the reagents kits to the end users

  12. ConKit: a python interface to contact predictions.

    Science.gov (United States)

    Simkovic, Felix; Thomas, Jens M H; Rigden, Daniel J

    2017-07-15

    Recent advances in protein residue contact prediction algorithms have led to the emergence of many new methods and a variety of file formats. We present ConKit , an open source, modular and extensible Python interface which allows facile conversion between formats and provides an interface to analyses of sequence alignments and sets of contact predictions. ConKit is available via the Python Package Index. The documentation can be found at http://www.conkit.org . ConKit is licensed under the BSD 3-Clause. hlfsimko@liverpool.ac.uk or drigden@liverpool.ac.uk. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

  13. Comparison of commercial diagnostic kits for placental lactogen radioimmunoassay

    International Nuclear Information System (INIS)

    Pirkl, S.; Kulenda, Z.

    1976-01-01

    The biochemical laboratory compared the following diagnostic kits for HPL determination: Pharmacia (Sweden), Radiochemical Center Amersham (GB), NEN (USA), Hoechst (FRG), applying the following criteria: 1. price, 2. number of analyses for which one kit may be applied, 3. expiration time, 4. speed, i.e., time elapsed from sample delivery to report (dependent on incubation time), 5. laboriousness, 6. reproducibility, 7. compatibility of values obtained by different kits. Alcohol precipitation (Pharmacia, RCC Amersham) appeared to be the most suitable while Dextran coated charcoal (NEN) and Amberlite (Hoechst) were somewhat more complicated, and the Sorin double antibody technique (ultrafiltration and washing of precipitate on filtres was used for separation) appeared to be the most laborious technique. RCC Amersham was ranked first owing to its lower cost as compared with runner-up Pharmacia. (L.O.)

  14. Determination of stannous tin in radiopharmaceutical cold kits

    International Nuclear Information System (INIS)

    Farrant, A.J.

    1979-01-01

    Two methods for determining stannous tin in 'cold kits', used for the preparation of Tc-99m labelled radiopharmaceuticals, have been developed. Both are based on the direct titration of the Sn2 in solution. In the first method titration is with N-bromosuccinimide. Of the materials commonly used as cold kits only albumin has been found to interfere with the determination. The second method is a standard iodometric titration in which starch is used as indicator. None of the materials tested interfere with this procedure. The N-bromosuccinimide method is the method of choice as the re-agent, a solid, can be used without prior standardization. Iodine solution must be standardized daily. The paper describes in detail the methods used and gives examples of kits in which the Sn2 levels have been determined using the described procedures

  15. Field Test Kit for Gun Residue Detection; TOPICAL

    International Nuclear Information System (INIS)

    WALKER, PAMELA K.; RODACY, PHILIP J.

    2002-01-01

    One of the major needs of the law enforcement field is a product that quickly, accurately, and inexpensively identifies whether a person has recently fired a gun--even if the suspect has attempted to wash the traces of gunpowder off. The Field Test Kit for Gunshot Residue Identification based on Sandia National Laboratories technology works with a wide variety of handguns and other weaponry using gunpowder. There are several organic chemicals in small arms propellants such as nitrocellulose, nitroglycerine, dinitrotoluene, and nitrites left behind after the firing of a gun that result from the incomplete combustion of the gunpowder. Sandia has developed a colorimetric shooter identification kit for in situ detection of gunshot residue (GSR) from a suspect. The test kit is the first of its kind and is small, inexpensive, and easily transported by individual law enforcement personnel requiring minimal training for effective use. It will provide immediate information identifying gunshot residue

  16. Fundamental and clinical study for PHT (parathyroid hormone) kit 'Yamasa'

    International Nuclear Information System (INIS)

    Fukunaga, Masao; Otsuka, Nobuaki; Furukawa, Takako; Morita, Rikushi

    1987-01-01

    A commercially available radioimmunoassay kit (Yamasa) for parathyroid hormone (PTH) is the midregion-specific assay system. Fundamental study of the PTH kit gave favorable results for specificity, reproducibility, dilution, and recovery. The serum PTH concentration was detectable among all 41 normal volunteers. The upper and lower limits of normal for PTH in serum were found to be 600 pg/ml and 184 pg/ml, respectively. PTH values were high for chronic renal failure (6/7) and primary hyperparathyroidism (41/41), and low for malignancy associated with hypercalcemia (5/25). It seems possible to discriminate hypercalcemic from normal subjects. The serum PTH concentration from the present assay system was significantly correlated with that from conventional carboxyl-terminal PTH, midregion PTH, amino-terminal PTH, and (1 - 84) PTH assay systems. The results indicate the potential of the Yamasa kit in evaluating calcium metabolism, as well as in detecting the presence of secondary hyperparathyroidism. (Namekawa, K.)

  17. Nuclear track detector kit for use in teaching

    Energy Technology Data Exchange (ETDEWEB)

    Medveczky, L.; Somogyi, G.; Nagy, M.

    1986-01-01

    By the use of solid state nuclear track detectors (SSNTDs) one may carry out several useful and impressive educational experiments and demonstrations to illustrate different phenomena when teaching of nuclear physics. Realizing this situation the authors have published, since 1970, reports on several experiments for teaching demonstrations. Based on the authors instructions, a factory in Hungary (TANFRT, National Manufacturers and Suppliers of School Equipment, Budapest) constructed a kit for the use of nuclear track detectors in teaching. The portable kit contains the following items: alpha-emitting weak sources, solid state nuclear track detectors (unirradiated, irradiated, unetched and etched sheets), simple tools for carrying out experiments (facilities for irradiation and etching, etc.), slides showing photos of typical etch-tracks of light and heavy nuclei, user manual. By the help of the kit both pupils and teachers can perform various useful experiments and/or demonstrations.

  18. Performance of immunoassay kits for site characterization and remediation

    International Nuclear Information System (INIS)

    Waters, L.C.; Palausky, A.; Counts, R.W.; Jenkins, R.A.

    1995-01-01

    The US Department of Energy (DOE) is supporting efforts to identify, validate and implement the use of effective, low-cost alternatives to currently used analytical methods for environmental management. As part of that program, we have evaluated the performances of a number of immunoassay (IA) kits with specificities for environmental contaminants of concern to the DOE. The studies were done in the laboratory using both spiked and field test samples. The analyte specificity and manufacturers of the kits evaluated were the following: mercury, BioNebraska; polychlorinated biphenyls (PCBs), EnSys and Millipore; petroleum fuel hydrocarbons, Millipore and Ohmicron; and polyaromatic hydrocarbons (PAHs), Ohmicron and Millipore. The kits were used in either a semiquantitative or quantitative format according to the preference of the manufacturers

  19. Transporting radioactive rock

    International Nuclear Information System (INIS)

    Pearce, G.

    1990-01-01

    The case is made for exempting geological specimens from the IAEA Regulations for Safer Transport of Radioactive Materials. It is pointed out that many mineral collectors in Devon and Cornwall may be unwittingly infringing these regulations by taking naturally radioactive rocks and specimens containing uranium ores. Even if these collectors are aware that these rocks are radioactive, and many are not, few have the necessary equipment to monitor the activity levels. If the transport regulations were to be enforced alarm could be generated and the regulations devalued in case of an accident. The danger from a spill of rock specimens is negligible compared with an accident involving industrial or medical radioactive substances yet would require similar special treatment. (UK)

  20. Disposable collection kit for rapid and reliable collection of saliva.

    Science.gov (United States)

    Yamaguchi, Masaki; Tezuka, Yuki; Takeda, Kazunori; Shetty, Vivek

    2015-01-01

    To describe and evaluate disposable saliva collection kit for rapid, reliable, and reproducible collection of saliva samples. The saliva collection kit comprised of a saliva absorbent swab and an extractor unit was used to retrieve whole saliva samples from 10 subjects. The accuracy and precision of the extracted volumes (3, 10, and 30 μl) were compared to similar volumes drawn from control samples obtained by passive drool. Additionally, the impact of kit collection method on subsequent immunoassay results was verified by assessing salivary cortisol levels in the samples and comparing them to controls. The recovered volumes for the whole saliva samples were 3.85 ± 0.28, 10.79 ± 0.95, and 31.18 ± 1.72 μl, respectively (CV = 8.76%) and 2.91 ± 0.19, 9.75 ± 0.43, and 29.64 ± 0.91 μl, respectively, (CV = 6.36%) for the controls. There was a close correspondence between the salivary cortisol levels from the saliva samples obtained by the collection kit and the controls (R(2)  > 0.96). The disposable saliva collection kit allows accurate and repeatable collection of fixed amounts of whole saliva and does not interfere with subsequent measurements of salivary cortisol. The simple collection process, lack of elaborate specimen recovery steps, and the short turnaround time (<3 min) should render the kit attractive to test subjects and researchers alike. © 2015 Wiley Periodicals, Inc.

  1. The Quality Lighting Teaching Kit: enlightening our future

    Science.gov (United States)

    Walker, Constance E.; Pompea, Stephen M.

    2016-09-01

    The U.S. National Optical Astronomy Observatory's Education and Public Outreach group has produced a Quality Lighting Teaching (QLT) Kit, as an outcome of the International Year of Light 2015. The kits are designed around problem-based learning scenarios. The kit's six activities allow students to address real lighting problems that relate to wildlife, sky glow, aging eyes, energy consumption, safety, and light trespass. The activities are optimized for 11-14 year olds but can be expanded to younger and older. Most of the activities can be done within in a few minutes with the exception of the Energy Activity. The activities can be done during class or afterschool and as stations (that the students rotate through) or as stand-alones (one at a time). All aspects of the program are as ready-for-use. Everything you need for the six activities is included in the kit. Tutorial videos (on the program's webpage) have been created on how to do the activities. They can be found on the webpage, www.noao.edu/education/qltkit.php. Fourteen Google+ Hangouts on Air have been offered, addressing questions on the activities and logistics. Assessments (in the form of pre- and post-surveys for the students and as post-surveys for the instructors) provide learning outcomes and improvements. Eighty-nine out of 100 kits have been distributed to SPIE, OSA, CIE, IDA and the IAU in 31 countries. The QLT Kit is a stepping-stone to bring awareness to the (younger) public on how quality lighting locally can redress issues like light pollution globally.

  2. Geotechnical properties of rock

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, R.; Gorski, B.; Gyenge, M.

    1995-12-31

    The manual is a compilation of the geotechnical properties of many types of rock that are typical of Canadian mining environments. Included are values for density, porosity, compressive and shear wave velocity, uniaxial compressive strength, Young`s modulus, and Poisson`s ratio. The data base contains material constants that were determined using the Hoek and Brown failure criteria for both before and after failure conditions. 76 data sheets of rock properties in Canadian mines are included. 7 refs., 85 figs., 3 tabs.

  3. Smart Rocking Armour Units

    OpenAIRE

    Hofland, B.; Arefin, Syed Shamsil; van der Lem, Cock; van gent, Marcel

    2018-01-01

    This paper describes a method to measure the rocking motion of lab-scale armour units. Sensors as found in mobile phones are used. These sensors, data-storage and battery are all embedded in the model units, such that they can be applied without wires attached to them. The technique is applied to double-layer units in order to compare the results to the existing knowledge for this type of armour layers. In contrast to previous research, the gyroscope reading is used to determine the (rocking)...

  4. Rock Hellsinki, Marketing Research

    OpenAIRE

    Todd, Roosa; Jalkanen, Katariina

    2013-01-01

    This paper is a qualitative research about rock and heavy metal music tourism in the capital city of Finland, Helsinki. As Helsinki can be considered the city of contrasts, the silent nature city mixed with urban activities, it is important to also use the potential of the loud rock and heavy metal music contrasting the silence. Finland is known abroad for bands such as HIM, Nightwish, Korpiklaani and Children of Bodom so it would make sense to utilize these in the tourism sector as well. The...

  5. GossipKit: A Framework of Gossip Protocol Family

    OpenAIRE

    Lin, Shen; Taiani, Francois; Blair, Gordon S.

    2007-01-01

    A large number of gossip protocols have been developed in the last few years to address a wide range of functionalities. So far, however, very few software frameworks have been proposed to ease the development and deployment of these gossip protocols. To address this issue, this paper presents GossipKit, an event-driven framework that provides a generic and extensible architecture for the development of (re)configurable gossip-oriented middleware. GossipKit is based on a generic interaction m...

  6. Tc99m MDP kits, production and quality control

    International Nuclear Information System (INIS)

    Othman, I.; Yassine, T.; Lababidi, Z.; Kouli, M.

    1992-11-01

    MDP kits for labelling with Tc 99m were locally produced in different conditions, and the conditions for preparation were optimized. The quality control studies showed that the prepared kits were very good quality and comparable with that imported. Radiochemical purities ranged between 95-98% while reduced technetium ranged between 2-3% and free pertechnetate did not exceed 1%. Bioscan and biodistribution studies also showed high localization of Tc 99m in the skeleton of rats and rabbits. (author). 8 refs., 14 tabs

  7. Determination of triiodothyronine using RIA-Mat T3 kit

    International Nuclear Information System (INIS)

    Hara, Masao

    1975-01-01

    A RIA-Mat T 3 kit was used for an in vitro measurement of triiodothyronine in serum. A resin strip was utilized to absorb free triiodothyronine after the serum was incubated with antibody against triiodothyronine. This test was easy to manipulate and the reproducibility test with same sera, dilution test, and recovery test were also satisfactory. The normal range of triiodothyronine determined with this test kit was 119 +- 40 ng/dl using 50 test sera. Ninety sera with various thyroid diseases were also determined. (auth.)

  8. Evaluation of the Ramco kit for serum ferritin assay

    Energy Technology Data Exchange (ETDEWEB)

    Dempster, W S; Knight, G J [Red Cross War Memorial Children' s Hospital, Cape Town (South Africa). Department of Paediatrics and Child Health; Jacobs, P [Cape Town Univ. (South Africa). Dept. of Haematology

    1979-12-22

    The determination of serum ferritin levels may be of diagnostic importance in medicine. To establish whether values obtained using a commercially available kit (Ramco) were adequate for this purpose, a comparison was undertaken using a two-site immunoradiometric assay that had been developed and standardized in our laboratories. Over the range 6..mu..g/l to greater than 2 000 ..mu..g/l there was a correlation coefficient between the two methods of 0,8284 (P smaller than 0,001). It is concluded that the Ramco kit is suitable for use in clinical practice.

  9. An evaluation of the Ramco kit for serum ferritin assay

    International Nuclear Information System (INIS)

    Dempster, W.S.; Knight, G.J.; Jacobs, P.

    1979-01-01

    The determination of serum ferritin levels may be of diagnostic importance in medicine. To establish whether values obtained using a commercially available kit (Ramco) were adequate for this purpose, a comparison was undertaken using a two-site immunoradiometric assay that had been developed and standardized in our laboratories. Over the range 6μg/l to greater than 2 000 μg/l there was a correlation coefficient between the two methods of 0,8284 (P smaller than 0,001). It is concluded that the Ramco kit is suitable for use in clinical practice

  10. RestKit for iOS standard guide

    CERN Document Server

    Kalapun, Taras

    2013-01-01

    A step-by-step, example-based guide to learning how you can link your apps and web services using RestKit.This book is for iOS developers of all levels who are interested in boosting their productivity by utilizing third party libraries and who have a willingness to learn how to build RESTful apps using the RestKit framework. A basic knowledge of Objective-C is required as well as a simple understanding of how to use CoreData.

  11. Stress Analysis and Model Test of Rock Breaking by Arc Blade Wedged Hob

    Directory of Open Access Journals (Sweden)

    Ying-chao Liu

    2016-07-01

    Full Text Available Based on rock compression-shear damage theory, the mechanical characteristics of an arc blade wedged hob were analyzed to study the rock fragmentation mechanism of hob during excavation, and rock fragmentation forecasting model of the arc blade wedged hob was improved. A spoke type cutter model which is similar to the tunnel boring machine (TBM cutter head was designed to study the rock fragmentation efficiency in different cutter spacing by adjusting the bearing sleeve size to obtain different distances between the hobs. The results show that the hob-breaking rock force mainly comes from three directions. The vertical force along the direction of the tunnel excavation, which is associated with uniaxial compressive strength of rock mass, plays a key role in the process of rock fragmentation. Field project data shows that the prediction model’s results of rock fragmentation in this paper are closer to the measured results than the results of the traditional linear cutting model. The optimal cutter spacing exists among different cutter spacings to get higher rock fragmentation rate and lower energy consumption during rock fragmentation. It is of great reference significance to design the arc blade wedged hob and enhance the efficiency of rock fragmentation in rock strata.

  12. Rock Burst Mechanics: Insight from Physical and Mathematical Modelling

    Directory of Open Access Journals (Sweden)

    J. Vacek

    2008-01-01

    Full Text Available Rock burst processes in mines are studied by many groups active in the field of geomechanics. Physical and mathematical modelling can be used to better understand the phenomena and mechanisms involved in the bursts. In the present paper we describe both physical and mathematical models of a rock burst occurring in a gallery of a coal mine.For rock bursts (also called bumps to occur, the rock has to possess certain particular rock burst properties leading to accumulation of energy and the potential to release this energy. Such materials may be brittle, or the rock burst may arise at the interfacial zones of two parts of the rock, which have principally different material properties (e.g. in the Poíbram uranium mines.The solution is based on experimental and mathematical modelling. These two methods have to allow the problem to be studied on the basis of three presumptions:· the solution must be time dependent,· the solution must allow the creation of cracks in the rock mass,· the solution must allow an extrusion of rock into an open space (bump effect. 

  13. Developing Save Your Food Kit (Sayofu Kit) to Support Inquiry, Improve Student Learning Outcomes at SMP Plus Hidayatul Mubtadiin and Public Awareness on Food Additives

    Science.gov (United States)

    Astutik, J.

    2017-02-01

    Food additives are materials that can not be separated from the lives of students and the community. Based on the preliminary questionnaire, it indicates the lack of kit supporting material additives in some schools and communities. The research objectives of this development are (1) to develop Kit experiment (SAYOFU KIT) and supplementary books to improve student learning outcomes in the classroom and public awareness on food additives (2) to describe the feasibility and potential effectiveness of SAYOFU KIT developed (3) to analyze the practice of SAYOFU KIT and benefits for students and the community. This development study uses 4-D models Thiagarajan, et al (1974). Through some stages, they are: defining, designing, developing and disseminating which involes the students and community. The developed SAYOFU KIT includes additives sample kit, borax test kit, curcumin test kit, formaldehyde test kit, modification heater to the identification of dyes and dye test paper. The study is conducted at SMP Plus Hidayatul Mubtadiin, and TKIT Al Uswah. The products are validated by experts and education practitioners. Qualitative data processing uses descriptive method, whereas quantitative data by using the N-gain. The average yield of expert validation of SAYOFU KIT with supplementary books 76.50% teacher’s book and 76.30% student’s book are eligible. The average yield of 96.81% validation of educational practitioners criteria, piloting a small group of 83.15%, and 82.89% field trials are very decent. The average yield on the student questionnaire responses SAYOFU kit and supplementary book is 87.6% with the criteria very well worth it. N-Gain 0:56 cognitive achievement with the criteria enough. The results of the public poll showed 95% feel the benefits SAYOFU kits for testing food. Based from description indicates that SAYOFU Kit developed feasible, practical, useful to support inquiry learning and improve student learning outcomes as well as public awareness of

  14. Islands and Islandness in Rock Music Lyrics

    Directory of Open Access Journals (Sweden)

    Daniele Mezzana

    2012-05-01

    Full Text Available This paper presents a first exploration, qualitative in character, based on a review of 412 songs produced in the period 1960-2009, about islands in rock music as both social products and social tools potentially contributing to shaping ideas, emotions, will, and desires. An initial taxonomy of 24 themes clustered under five meta-themes of space, lifestyle, emotions, symbolism, and social-political relations is provided, together with some proposals for further research.

  15. Stability of Pharmaceuticals in Space

    Science.gov (United States)

    Nguyen, Y-Uyen

    2009-01-01

    Stability testing is a tool used to access shelf life and effects of storage conditions for pharmaceutical formulations. Early research from the International Space Station (ISS) revealed that some medications may have degraded while in space. This potential loss of medication efficacy would be very dangerous to Crew health. The aim of this research project, Stability of Pharmacotherapeutic Compounds, is to study how the stability of pharmaceutical compounds is affected by environmental conditions in space. Four identical pharmaceutical payload kits containing medications in different dosage forms (liquid for injection, tablet, capsule, ointment and suppository) were transported to the ISS aboard a Space Shuttle. One of the four kits was stored on that Shuttle and the other three were stored on the ISS for return to Earth at various time intervals aboard a pre-designated Shuttle flight. The Pharmacotherapeutics laboratory used stability test as defined by the United States Pharmacopeia (USP), to access the degree of degradation to the Payload kit medications that may have occurred during space flight. Once these medications returned, the results of stability test performed on them were compared to those from the matching ground controls stored on Earth. Analyses of the results obtained from physical and chemical stability assessments on these payload medications will provide researchers additional tools to promote safe and efficacious medications for space exploration.

  16. Concept and set-up of an IR-gas sensor construction kit

    Science.gov (United States)

    Sieber, Ingo; Perner, Gernot; Gengenbach, Ulrich

    2015-10-01

    The paper presents an approach to a cost-efficient modularly built non-dispersive optical IR-gas sensor (NDIR) based on a construction kit. The modularity of the approach offers several advantages: First of all it allows for an adaptation of the performance of the gas sensor to individual specifications by choosing the suitable modular components. The sensitivity of the sensor e.g. can be altered by selecting a source which emits a favorable wavelength spectrum with respect to the absorption spectrum of the gas to be measured or by tuning the measuring distance (ray path inside the medium to be measured). Furthermore the developed approach is very well suited to be used in teaching. Together with students a construction kit on basis of an optical free space system was developed and partly implemented to be further used as a teaching and training aid for bachelor and master students at our institute. The components of the construction kit are interchangeable and freely fixable on a base plate. The components are classified into five groups: sources, reflectors, detectors, gas feed, and analysis cell. Source, detector, and the positions of the components are fundamental to experiment and test different configurations and beam paths. The reflectors are implemented by an aluminum coated adhesive foil, mounted onto a support structure fabricated by additive manufacturing. This approach allows derivation of the reflecting surface geometry from the optical design tool and generating the 3D-printing files by applying related design rules. The rapid fabrication process and the adjustment of the modules on the base plate allow rapid, almost LEGO®-like, experimental assessment of design ideas. Subject of this paper is modeling, design, and optimization of the reflective optical components, as well as of the optical subsystem. The realization of a sample set-up used as a teaching aid and the optical measurement of the beam path in comparison to the simulation results are

  17. A Rock Retrospective.

    Science.gov (United States)

    O'Grady, Terence J.

    1979-01-01

    The author offers an analysis of musical techniques found in the major rock trends of the 1960s. An annotated list of selected readings and a subject-indexed list of selected recordings are appended. This article is part of a theme issue on popular music. (Editor/SJL)

  18. Rock-hard coatings

    OpenAIRE

    Muller, M.

    2007-01-01

    Aircraft jet engines have to be able to withstand infernal conditions. Extreme heat and bitter cold tax coatings to the limit. Materials expert Dr Ir. Wim Sloof fits atoms together to develop rock-hard coatings. The latest invention in this field is known as ceramic matrix composites. Sloof has signed an agreement with a number of parties to investigate this material further.

  19. Fluids in metamorphic rocks

    NARCIS (Netherlands)

    Touret, J.L.R.

    2001-01-01

    Basic principles for the study of fluid inclusions in metamorphic rocks are reviewed and illustrated. A major problem relates to the number of inclusions, possibly formed on a wide range of P-T conditions, having also suffered, in most cases, extensive changes after initial trapping. The

  20. Rock-hard coatings

    NARCIS (Netherlands)

    Muller, M.

    2007-01-01

    Aircraft jet engines have to be able to withstand infernal conditions. Extreme heat and bitter cold tax coatings to the limit. Materials expert Dr Ir. Wim Sloof fits atoms together to develop rock-hard coatings. The latest invention in this field is known as ceramic matrix composites. Sloof has

  1. Northeast Church Rock Mine

    Science.gov (United States)

    Northeast Church Rock Mine, a former uranium mine 17 miles northeast of Gallup, NM in the Pinedale Chapter of the Navajo Nation. EPA is working with NNEPA to oversee cleanup work by United Nuclear Corporation, a company owned by General Electric (GE).

  2. Smart Rocking Armour Units

    NARCIS (Netherlands)

    Hofland, B.; Arefin, Syed Shamsil; van der Lem, Cock; van gent, Marcel

    2018-01-01

    This paper describes a method to measure the rocking motion of lab-scale armour units. Sensors as found in mobile phones are used. These sensors, data-storage and battery are all embedded in the model units, such that they can be applied without wires attached to them. The technique is applied to

  3. KIT competence center for decommissioning. Innovation and promotion of trainees; Kompetenzzentrum Rueckbau am KIT. Nachwuchsfoerderung und Innovationen fuer den Rueckbau

    Energy Technology Data Exchange (ETDEWEB)

    Gentes, Sascha [Karlsruher Institut fuer Technologie (KIT), Karlsruhe (Germany). Inst. fuer Technologie und Management im Baubetrieb

    2016-03-15

    The safe decommissioning of nuclear installations is technically feasible, but is also still a challenge for science, technology and industry. The expertise and know how for decommissioning must be ensured because it will be needed for further decades. Already in 2008 the Karlsruhe Institute of Technology (KIT) had identified this challenge that later emerged through the closure of nuclear power plants in Germany. The KIT opened the professorship Technology and Management of the Decommissioning of Nuclear Installations. In 2014, this section was extended through the dismantling of conventional installations.

  4. Teaching the Rock Cycle with Ease.

    Science.gov (United States)

    Bereki, Debra

    2000-01-01

    Describes a hands-on lesson for teaching high school students the concept of the rock cycle using sedimentary, metamorphic, and igneous rocks. Students use a rock cycle diagram to identify pairs of rocks. From the rock cycle, students explain on paper how their first rock became the second rock and vice versa. (PVD)

  5. Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumors

    International Nuclear Information System (INIS)

    Webster, Joshua D; Kiupel, Matti; Yuzbasiyan-Gurkan, Vilma

    2006-01-01

    Mutations in the c-KIT proto-oncogene have been implicated in the progression of several neoplastic diseases, including gastrointestinal stromal tumors and mastocytosis in humans, and cutaneous mast cell tumors (MCTs) in canines. Mutations in human mastocytosis patients primarily occur in c-KIT exon 17, which encodes a portion of its kinase domain. In contrast, deletions and internal tandem duplication (ITD) mutations are found in the juxtamembrane domain of c-KIT in approximately 15% of canine MCTs. In addition, ITD c-KIT mutations are significantly associated with aberrant KIT protein localization in canine MCTs. However, some canine MCTs have aberrant KIT localization but lack ITD c-KIT mutations, suggesting that other mutations or other factors may be responsible for aberrant KIT localization in these tumors. In order to characterize the prevalence of mutations in the phospho-transferase portion of c-KIT's kinase domain in canine MCTs exons 16–20 of 33 canine MCTs from 33 dogs were amplified and sequenced. Additionally, in order to determine if mutations in c-KIT exon 17 are responsible for aberrant KIT localization in MCTs that lack juxtamembrane domain c-KIT mutations, c-KIT exon 17 was amplified and sequenced from 18 canine MCTs that showed an aberrant KIT localization pattern but did not have ITD c-KIT mutations. No mutations or polymorphisms were identified in exons 16–20 of any of the MCTs examined. In conclusion, mutations in the phospho-transferase portion of c-KIT's kinase domain do not play an important role in the progression of canine cutaneous MCTs, or in the aberrant localization of KIT in canine MCTs

  6. For Those About to Rock : Naislaulajat rock-genressä

    OpenAIRE

    Herranen, Linda

    2015-01-01

    For those about to rock – naislaulajat rock-genressä antaa lukijalleen kokonaisvaltaisen käsityksen naisista rock-genressä: rockin historiasta, sukupuolittuneisuudesta, seksismistä, suomalaisten naislaulajien menestyksestä. Työn aineisto on koottu aihepiirin kirjallisuudesta ja alalla toimiville naislaulajille teetettyjen kyselyiden tuloksista. Lisäksi avaan omia kokemuksiani ja ajatuksiani, jotta näkökulma naisista rock-genressä tulisi esille mahdollisimman monipuolisesti. Ajatus aihees...

  7. Comparison of disposal concepts for rock salt and hard rock

    International Nuclear Information System (INIS)

    Papp, R.

    1998-01-01

    The study was carried out in the period 1994-1996. The goals were to prepare a draft on spent fuel disposal in hard rock and additionally a comparison with existing disposal concepts for rock salt. A cask for direct disposal of spent fuel and a repository for hard rock including a safeguards concept were conceptually designed. The results of the study confirm, that the early German decision to employ rock salt was reasonable. (orig.)

  8. Elastic Rock Heterogeneity Controls Brittle Rock Failure during Hydraulic Fracturing

    Science.gov (United States)

    Langenbruch, C.; Shapiro, S. A.

    2014-12-01

    For interpretation and inversion of microseismic data it is important to understand, which properties of the reservoir rock control the occurrence probability of brittle rock failure and associated seismicity during hydraulic stimulation. This is especially important, when inverting for key properties like permeability and fracture conductivity. Although it became accepted that seismic events are triggered by fluid flow and the resulting perturbation of the stress field in the reservoir rock, the magnitude of stress perturbations, capable of triggering failure in rocks, can be highly variable. The controlling physical mechanism of this variability is still under discussion. We compare the occurrence of microseismic events at the Cotton Valley gas field to elastic rock heterogeneity, obtained from measurements along the treatment wells. The heterogeneity is characterized by scale invariant fluctuations of elastic properties. We observe that the elastic heterogeneity of the rock formation controls the occurrence of brittle failure. In particular, we find that the density of events is increasing with the Brittleness Index (BI) of the rock, which is defined as a combination of Young's modulus and Poisson's ratio. We evaluate the physical meaning of the BI. By applying geomechanical investigations we characterize the influence of fluctuating elastic properties in rocks on the probability of brittle rock failure. Our analysis is based on the computation of stress fluctuations caused by elastic heterogeneity of rocks. We find that elastic rock heterogeneity causes stress fluctuations of significant magnitude. Moreover, the stress changes necessary to open and reactivate fractures in rocks are strongly related to fluctuations of elastic moduli. Our analysis gives a physical explanation to the observed relation between elastic heterogeneity of the rock formation and the occurrence of brittle failure during hydraulic reservoir stimulations. A crucial factor for understanding

  9. National High Blood Pressure 12-Month Kit. May 1988.

    Science.gov (United States)

    National Heart and Lung Inst. (DHHS/NIH), Bethesda, MD. National High Blood Pressure Education Program.

    Part I of this kit provides information for program planners and health professionals on ways to overcome barriers to health care among the medically underserved, promote high blood pressure control through the media and other community channels, and improve adherence to treatment among hypertensive patients. It lists additional resources for…

  10. Media Kit on WDM in MENA | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This kit contains information tailored primarily for the media community. It contains up-to-date knowledge about water demand management in the form of policy briefs, success stories, water briefs, a brochure and a CD in English, French and Arabic. This material explains water demand management and the contributions of ...

  11. [Effect evaluation of three ELISA kits in detection of fasciolasis].

    Science.gov (United States)

    Ai, Lin; Chen, Mu-Xin; Chen, Shao-Hong; Chu, Yan-Hong; Cai, Yu-Chun; Zhou, Xiao-Nong; Chen, Jia-Xu

    2013-04-01

    To evaluate the effect of 3 ELISA kits on detection of human fasciolasis. Twenty-six serum samples from patients with fasciolasis, 180 serum samples from patients with other parasitic diseases as well as 26 serum samples from healthy people were detected by ELISA kits which using soluble antigen of Fasciola gigantica, Fasciola hepatica (Fg-ELISA and Fh-ELISA) as well as IgG antigen ELISA detection kits made by DRG company in Germany. The effects of the 3 kits were evaluated. The sensitivities of Fg-ELISA, Fh-ELISA, and DRG-ELISA were 100.0%, 80.8% (95% CI: 65.7%-95.9%) and 100.0%, respectively; the specificities of the three were 87.9% (95% CI: 83.5%-92.4%), 85.0%(95% CI: 80.1%-89.9%) and 83.5% (95% CI: 78.4%-88.6%), respectively, and Youden indexes of them were 0.88, 0.66 and 0.84, respectively. The detection rate of Fg-ELISA (100%) was significantly higher than that of Fh-ELISA (80.8%) (P DRG-ELISA for clinical sample tests as well as massive screening in fasciolasis endemic areas in southwest China.

  12. Programming with the KIBO Robotics Kit in Preschool Classrooms

    Science.gov (United States)

    Elkin, Mollie; Sullivan, Amanda; Bers, Marina Umaschi

    2016-01-01

    KIBO is a developmentally appropriate robotics kit for young children that is programmed using interlocking wooden blocks; no screens or keyboards are required. This study describes a pilot KIBO robotics curriculum at an urban public preschool in Rhode Island and presents data collected on children's knowledge of foundational programming concepts…

  13. Documentation for MeshKit - Reactor Geometry (&mesh) Generator

    Energy Technology Data Exchange (ETDEWEB)

    Jain, Rajeev [Argonne National Lab. (ANL), Argonne, IL (United States); Mahadevan, Vijay [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-30

    This report gives documentation for using MeshKit’s Reactor Geometry (and mesh) Generator (RGG) GUI and also briefly documents other algorithms and tools available in MeshKit. RGG is a program designed to aid in modeling and meshing of complex/large hexagonal and rectilinear reactor cores. RGG uses Argonne’s SIGMA interfaces, Qt and VTK to produce an intuitive user interface. By integrating a 3D view of the reactor with the meshing tools and combining them into one user interface, RGG streamlines the task of preparing a simulation mesh and enables real-time feedback that reduces accidental scripting mistakes that could waste hours of meshing. RGG interfaces with MeshKit tools to consolidate the meshing process, meaning that going from model to mesh is as easy as a button click. This report is designed to explain RGG v 2.0 interface and provide users with the knowledge and skills to pilot RGG successfully. Brief documentation of MeshKit source code, tools and other algorithms available are also presented for developers to extend and add new algorithms to MeshKit. RGG tools work in serial and parallel and have been used to model complex reactor core models consisting of conical pins, load pads, several thousands of axially varying material properties of instrumentation pins and other interstices meshes.

  14. Safety of a disposable male circumcision kit. results from a ...

    African Journals Online (AJOL)

    ... disposable instruments, consumables and pharmaceutical products needed to perform one single male circumcision among young male adults according to the most common technique used in South Africa (the Forceps Guided technique). The objective of this study was to evaluate the safety of this new circumcision kit.

  15. Enhancing Science Kits with the Driving Question Board

    Science.gov (United States)

    Nordine, Jeff; Torres, Ruben

    2013-01-01

    This article describes the driving question board (DQB), a visual organizer that supports inquiry-based instruction through the use of guiding questions. The DQB is a teaching aid designed to increase student engagement alongside science kits. Information is provided on its application to a lesson on buoyancy, highlighting how it improved…

  16. Optimization Of Preparation And Validation Of Hepatitis C Irma Kit

    International Nuclear Information System (INIS)

    Ariyanto, Agus; Wayan, R.S.; Sukiyati, Dj.; Darwati, Siti; Yunita, Fitri; Mondrida, Gina; Sulaiman; Yulianti, Veronika; Setiowati, Sri

    2000-01-01

    Optimization of preparation and validation of hepatitis C IRMA kit have been done. Tracer was prepared by iodination of anti-hlgG with 125 I using Choramin-T and N-Bromosuksinimide as oxidizing agent. Iodinated anti-hlgG was purified using PD-10 and Sephadex G-50 column. Coated bead was prepared by immobilization of antigen HCV recombinant on polystyrene bead. To obtain a good quality of reagent some parameters were optimized i.e.: colim used for purification. To determine the validity of the kit, validation which include comparison study and determination of specificity and sensitivity have been performed. A good quality of tracer has been able to prepared with high yield (74%) and high P/N value (15). The quality of coated bead is also reasonably good (P/N 34.3), and gave a good density and dissociation index (0.335 and 0.99% respectively). Both tracer and coated bead were remain stable after 2 months storage at 4 o C. In comparison with Elisa kit, the specificity and sensitivity of the HCV IRMA kit is reasonably high, 88.6% and 92.3% respectively

  17. Lab at Home: Hardware Kits for a Digital Design Lab

    Science.gov (United States)

    Oliver, J. P.; Haim, F.

    2009-01-01

    An innovative laboratory methodology for an introductory digital design course is presented. Instead of having traditional lab experiences, where students have to come to school classrooms, a "lab at home" concept is proposed. Students perform real experiments in their own homes, using hardware kits specially developed for this purpose. They…

  18. Volatile constituents of Glechoma hirsute Waldst. & Kit. and G ...

    African Journals Online (AJOL)

    The essential oils of two Glechoma species from Serbia have been analyzed by GC and GC/MS. Eighty eight and two hundred thirty eight constituents identified accounted for 90.6 and 86.6% of the total oils of G. hirsuta Waldst. & Kit. and G. hederacea L., respectively. In both oils the dominant constituent class was the ...

  19. 21 CFR 864.1860 - Immunohistochemistry reagents and kits.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Immunohistochemistry reagents and kits. 864.1860 Section 864.1860 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Biological Stains § 864.1860...

  20. INDOOR AIR QUALITY AND INHALATION EXPOSURE - SIMULATION TOOL KIT

    Science.gov (United States)

    A Microsoft Windows-based indoor air quality (IAQ) simulation software package is presented. Named Simulation Tool Kit for Indoor Air Quality and Inhalation Exposure, or IAQX for short, this package complements and supplements existing IAQ simulation programs and is desi...

  1. Travel Policies in ARL Libraries. SPEC Kit 161.

    Science.gov (United States)

    Cramer, Michael D.

    This kit examines the methods and policies currently used to provide travel funding for academic librarians. The results of a survey of Association of Research Libraries (ARL) libraries (n=73) conducted in Fall 1989 are presented as well as examples of travel policies and guidelines submitted by the following respondents: the Universities of…

  2. Some existing Experimental Facilities for Fast Neutron Systems at KIT

    International Nuclear Information System (INIS)

    Litfin, K.

    2013-01-01

    An overview is given of: • Liquid Metal Loops at the Karlsruhe Liquid Metal Laboratory (KALLA) of KIT; • THESYS: Technologies for HEavy metal SYStems; • Thermal Hydraulic experiments in THESYS; • THEADES: THErmalhydraulics and Ads DESign; • Thermal Hydraulic experiments in THEADES; • CORRIDA: CORRosion In Dynamic lead Alloys; • Experimental stagnant facilities at KALLA; • INR Liquid metal research

  3. Studies on quality control of technetium-99m labelling kits

    International Nuclear Information System (INIS)

    Kim, Jae Rok; Park, Kyung Bae; Awh, Ok Doo

    1987-12-01

    Various experiments for the quality control of Tc-99m labelled radiopharmaceuticals such as Tc-99m-phytate, Tc-99m-MDP, Tc-99m-Tin Colloid, Tc-99m-DISIDA, Tc-99m-DTPA,Tc-99m-DMSA, Tc-99m-Gulcoheptonate, TC-99m-Pyrophosphate, Tc-99m-HSA, and Tc-99m-HAM were carried out. Labelling yield and radiochemical purity of each of the instant labelling kit of KAERI made were determined by means of radiochromatography. Biodistribution in mice and whole body or specific organ imagings of rabbits were also carried out and discussed the relationship between the data of biodistributions and radiochemical purities. Labelling yeilds were above 98% for almost all of the labelling kits. The radio-pharmaceuticals were accumulated at each target organ with moderate specifities. In case of radiochemical purity of above 98%, the biodistribution and gamma imagings were also better. The kits of MDP and DISIDA were stable at least for four moths while the other kits at least eight months. (Author)

  4. Food for Thought: A Population Simulation Kit. Revised.

    Science.gov (United States)

    Fletcher, Carol C.

    Designed to foster an understanding of some of the relationships among population growth and distribution of people, food, and land area, this simulation kit deals with the following concepts: (1) the finite nature of land and resources, (2) the size and rate of growth of population, (3) the unequal distribution of population throughout the world,…

  5. Milk intake in kits: not only the total amount matters

    Directory of Open Access Journals (Sweden)

    Alberto Arnau Bonachera

    2017-06-01

    Full Text Available The aim of this work was to identify milk intake variation patterns in kits throughout lactation, to evaluate their permanent maternal component and their relationships with the performance of kits before and after weaning. To achieve this goal, we used 73 rabbit does, controlled between the 1st and the 4th lactation, which kindled 229 litters with a total of 2225 kits. The daily milk intake records per young rabbit were analysed using a principal component analysis (PCA. We found that 72.3% of the variability was explained by the first 3 principal components (PCs. PC1 explained 46.4% of the total variability, was associated with the total amount of milk intake during lactation and presented a repeatability of 0.27 (P0.05. This component was little related to performance traits. Therefore, it seems that milk plays 2 different roles at the beginning of feed intake; the most important would affect development of the kits and thus is related with high intake. The second one, for a given total amount of milk intake during lactation, would create a kind of competition between milk and feed intake at the end of lactation. The effects of both components still persist during the growing period and seem to be moderately affected by the mother.

  6. KAPSE Interface Team (KIT) Public Report. Volume 8, Part 1

    Science.gov (United States)

    1989-10-01

    visitors were introduced. Mike Tedd of the University of Wales represented the United Kingdom on the KIT for Sue Bond , who will be the primary...CAIS subprogram callable by APSE tools.I 2.1 Scope of the CAIS. The CAIS shall provide interfaces sufficient to support the use of APSEs for wide

  7. Range sections as rock models for intensity rock scene segmentation

    CSIR Research Space (South Africa)

    Mkwelo, S

    2007-11-01

    Full Text Available This paper presents another approach to segmenting a scene of rocks on a conveyor belt for the purposes of measuring rock size. Rock size estimation instruments are used to monitor, optimize and control milling and crushing in the mining industry...

  8. Comparison of Thyroglobulin Measurements Using Three Different Immunoassay Kits: A BRAMHS Tg-Plus RIA Kit, a BRAMHS hTg Sensitive Kryptor Kit, and a Beckman Coulter ACCESS Immunoassay Kit

    Directory of Open Access Journals (Sweden)

    Mijin Kim

    2016-09-01

    Full Text Available BackgroundSecond-generation thyroglobulin immunometric assays (Tg-IMAs have been developed with improved sensitivity. Our aim was to compare the diagnostic value of Tg-IMA measurements using a Kryptor (BRAHMS AG kit (Tg-K and an ACCESS (Beckman Coulter kit (Tg-A with that of the first-generation Tg measurement using a Tg-plus (BRAHMS AG kit (Tg+.MethodsWe enrolled 82 differentiated thyroid cancer patients who underwent total thyroidectomy with radioactive iodine remnant ablation and who underwent diagnostic whole body scan using recombinant human thyroid stimulating hormone (rhTSH. The Tg+, Tg-K, and Tg-A were measured before rhTSH administration during levothyroxine treatment (suppressed Tg from the same sample. Serum Tg+ was measured after rhTSH stimulation (stimulated Tg.ResultsSuppressed Tg+ was more significantly correlated with suppressed Tg-K (R2=0.919, P<0.001 than with suppressed Tg-A (R2=0.536, P<0.001. The optimal cut-off values of suppressed Tg+, Tg-K, and Tg-A for predicting stimulated Tg+ of 1 ng/mL were 0.3, 0.2, and 0.2 ng/mL, respectively. The sensitivity, specificity, and accuracy of suppressed Tg+ were 67%, 100%, and 90%, respectively; those of suppressed Tg-K were 83%, 90%, and 88%; those of suppressed Tg-A were 96%, 82%, and 87%, respectively. The positive predictive and negative predictive values of Tg+ were 100% and 87%, respectively; those of Tg-K were 79% and 92%; and those of Tg-A were 73% and 98%.ConclusionWe could not clearly demonstrate which kit had better diagnostic performance after comparison of first-generation Tg measurements with Tg-IMA measurements. Also, there were kit-to-kit variations between Tg-IMA kits. Suppressed Tg measured by Tg-IMA was insufficient to completely substitute for a stimulated Tg measurement.

  9. Comparative studies of commercially available T4-RIA-kits. Pt. 2

    International Nuclear Information System (INIS)

    Schmidt, H.A.E.; Lipke, P.

    1978-01-01

    The investigation of the tested commercially available T 4 -RIA-Kits have shown that: The separation of hypo-, eu- and hyperthyroid values is better with kits a) and f) than with b), c), d) and e), though all kits give acceptable values under routine operating conditions, kit b) takes less time and work than the other tested kits, depending on the kit used, the time needed for 100 determinations varies between 1,5 and 4 hr. A general recommendation for one of the tested T 4 -RIA-Kits cannot be made since the choice of a kit depends not only on the criteria discussed but also on local circumstances. (orig.) [de

  10. Feasibility of fractionating Myoview cold kits for cost reduction

    International Nuclear Information System (INIS)

    Penglis, S.; Tsopelas, C.

    1999-01-01

    Full text: Myoview is a freeze-dried ethylene diphosphine ligand that upon reconstitution with 99 Tc m -pertechnetate yields a preparation containing the lipophilic cationic myocardial imaging agent 99 Tc m -tetrofosmin (Tf). The aim of this study was to determine the feasibility of fractionating Myoview kits to reduce the cost of the kit, currently A$350 per vial. Myoview vials were reconstituted with N 2 -flushed saline and split into 4 or 5 aliquots of 0.5 ml, then stored at -80 deg C in N 2 -filled vials for up to 3 months. 99 Tc m -Tf was prepared by the addition of varying volumes of 99 Tc m -pertechnetate (1.1 GBq.ml- 1 ) to give a final ligand concentration of 14.4 μg.ml- 1 , followed by a 15 min incubation at room temperature. Radiochemical purity (RCP) was examined at 0, 1, 2 and 3 months post-fractionation. At each time point, RCP was determined at 0,1, 2, 4, 6 and 24 h post-reconstitution. RCP was measured using the thin layer chromatography method according to the manufacturer's instructions. Over the 3 month evaluation period, RCP was maintained at 96.4 ± 1.7% (n = 48) over 24 h at room temperature. Animal biodistribution studies were used to validate the final product from the full cold kit to that from the fractionated kits. In conclusion, these results show that Myoview kits can be successfully fractionated and stored for up to 3 months. The subsequent 99 Tc m -Tf can be used to provide significant cost reductions, especially when only 1 patient dose is required

  11. A nuclear source: a resource kit for teachers

    International Nuclear Information System (INIS)

    Hawkins, Gay.

    1992-01-01

    The aim of this Resource Kit is to provide information, diagrams, overheads and classroom activities, set in an Australian context, to broaden and enrich the teaching of nuclear science from both technical and social science aspects. It has been written to address the the Australian secondary school syllabuses and reflects this in both its format and contents. Emphasis has been given to the applications of nuclear physics to our lives today, from new medical diagnostic techniques to efficient methods of monitoring our own environment. This Resource Kit is a valuable source of information not readily available to teachers from textbooks. It provides a unique opportunity to present the picture in Australia, making us all more aware of Australia's front line in Australia, making us all more aware of Australia's front line role in nuclear research. The kit is meant to be used in conjunction with current textbooks, to complement and enrich them. The kit begins with a review of the many applications of nuclear science in order to provide a broad concrete base to motivate students to discover more of the specific details of the basic discoveries contained in the later sections. Topics such as the Structure of the Atom, which are well documented in textbooks, have been approached in a more creative and less rigorous manner to give teachers a fresh approach to the topic. The kit is divided into 10 separate sections and presented in loose-leaf form to facilitate its use in the classroom. Diagrams are inserted into the text to clarify and enrich descriptions, as well as being provided at the back of each section as black line masters for photocopying and overhead projections. ills., tabs

  12. Critical issues in soft rocks

    OpenAIRE

    Milton Assis Kanji

    2014-01-01

    This paper discusses several efforts made to study and investigate soft rocks, as well as their physico-mechanical characteristics recognized up to now, the problems in their sampling and testing, and the possibility of its reproduction through artificially made soft rocks. The problems in utilizing current and widespread classification systems to some types of weak rocks are also discussed, as well as other problems related to them. Some examples of engineering works in soft rock or in soft ...

  13. Effect of planecta and ROSE? on the frequency characteristics of blood pressure-transducer kits

    OpenAIRE

    Fujiwara, Shigeki; Kawakubo, Yoshifumi; Mori, Satoshi; Tachihara, Keiichi; Toyoguchi, Izumi; Yokoyama, Takeshi

    2014-01-01

    Pressure-transducer kits have frequency characteristics such as natural frequency and damping coefficient, which affect the monitoring accuracy. The aim of the present study was to investigate the effect of planecta ports and a damping device (ROSE?, Argon Medical Devices, TX, USA) on the frequency characteristics of pressure-transducer kits. The FloTrac sensor kit (Edwards Lifesciences, CA, USA) and the DTXplus transducer kit (Argon Medical Devices) were prepared with planecta ports, and the...

  14. Expression of proto-oncogene KIT is up-regulated in subset of human meningiomas

    Directory of Open Access Journals (Sweden)

    Saini Masum

    2012-06-01

    Full Text Available Abstract Background KIT is a proto-oncogene involved in diverse neoplastic processes. Aberrant kinase activity of the KIT receptor has been targeted by tyrosine kinase inhibitor (TKI therapy in different neoplasias. In all the earlier studies, KIT expression was reported to be absent in meningiomas. However, we observed KIT mRNA expression in some meningioma cases. This prompted us to undertake its detailed analyses in meningioma tissues resected during 2008–2009. Methods Tumor tissues and matched peripheral blood samples collected from meningioma patients were used for detailed molecular analyses. KIT expression was ascertained immunohistochemically and validated by immunoblotting. KIT and KITLG transcript levels were discerned by reverse transcription quantitative real-time PCR (RT-qPCR. Similarly, KIT amplification and allele loss were assessed by quantitative real-time (qPCR and validated by fluorescence in situ hybridization (FISH on the neoplastic tissues. Possible alterations of the gene at the nucleotide level were analyzed by sequencing. Results Contrary to earlier reports, KIT expression, was detected immunohistochemically in 20.6% meningioma cases (n = 34. Receptor (KIT and ligand (KITLG transcripts monitored by RT-qPCR were found to co-express (p = 0.048 in most of the KIT immunopositive tumors. 1/7 KIT positive meningiomas showed allele loss corroborated by reduced FISH signal in the corresponding neoplastic tissue. Sequence analysis of KIT showed M541L substitution in exon 10, in one of the immunopositive cases. However, its biological consequence remains to be uncovered. Conclusions This study clearly demonstrates KIT over-expression in the human meningiomas. The data suggest that up-regulated KIT transcription (p  0.05, is a likely mechanism responsible for altered KIT expression. Thus, KIT is a potential candidate for detailed investigation in the context of meningioma pathogenesis.

  15. Expression of proto-oncogene KIT is up-regulated in subset of human meningiomas

    International Nuclear Information System (INIS)

    Saini, Masum; Jha, Ajaya Nand; Abrari, Andleeb; Ali, Sher

    2012-01-01

    KIT is a proto-oncogene involved in diverse neoplastic processes. Aberrant kinase activity of the KIT receptor has been targeted by tyrosine kinase inhibitor (TKI) therapy in different neoplasias. In all the earlier studies, KIT expression was reported to be absent in meningiomas. However, we observed KIT mRNA expression in some meningioma cases. This prompted us to undertake its detailed analyses in meningioma tissues resected during 2008–2009. Tumor tissues and matched peripheral blood samples collected from meningioma patients were used for detailed molecular analyses. KIT expression was ascertained immunohistochemically and validated by immunoblotting. KIT and KITLG transcript levels were discerned by reverse transcription quantitative real-time PCR (RT-qPCR). Similarly, KIT amplification and allele loss were assessed by quantitative real-time (qPCR) and validated by fluorescence in situ hybridization (FISH) on the neoplastic tissues. Possible alterations of the gene at the nucleotide level were analyzed by sequencing. Contrary to earlier reports, KIT expression, was detected immunohistochemically in 20.6% meningioma cases (n = 34). Receptor (KIT) and ligand (KITLG) transcripts monitored by RT-qPCR were found to co-express (p = 0.048) in most of the KIT immunopositive tumors. 1/7 KIT positive meningiomas showed allele loss corroborated by reduced FISH signal in the corresponding neoplastic tissue. Sequence analysis of KIT showed M541L substitution in exon 10, in one of the immunopositive cases. However, its biological consequence remains to be uncovered. This study clearly demonstrates KIT over-expression in the human meningiomas. The data suggest that up-regulated KIT transcription (p < 0.001), instead of gene amplification (p > 0.05), is a likely mechanism responsible for altered KIT expression. Thus, KIT is a potential candidate for detailed investigation in the context of meningioma pathogenesis

  16. Pathologic Stimulus Determines Lineage Commitment of Cardiac C-kit+ Cells.

    Science.gov (United States)

    Chen, Zhongming; Zhu, Wuqiang; Bender, Ingrid; Gong, Wuming; Kwak, Il-Youp; Yellamilli, Amritha; Hodges, Thomas J; Nemoto, Natsumi; Zhang, Jianyi; Garry, Daniel J; van Berlo, Jop H

    2017-12-12

    Although cardiac c-kit + cells are being tested in clinical trials, the circumstances that determine lineage differentiation of c-kit + cells in vivo are unknown. Recent findings suggest that endogenous cardiac c-kit + cells rarely contribute cardiomyocytes to the adult heart. We assessed whether various pathological stimuli differentially affect the eventual cell fates of c-kit + cells. We used single-cell sequencing and genetic lineage tracing of c-kit + cells to determine whether various pathological stimuli would result in different fates of c-kit + cells. Single-cell sequencing of cardiac CD45 - c-kit + cells showed innate heterogeneity, indicative of the existence of vascular and mesenchymal c-kit + cells in normal hearts. Cardiac pressure overload resulted in a modest increase in c-kit-derived cardiomyocytes, with significant increases in the numbers of endothelial cells and fibroblasts. Doxorubicin-induced acute cardiotoxicity did not increase c-kit-derived endothelial cell fates but instead induced cardiomyocyte differentiation. Mechanistically, doxorubicin-induced DNA damage in c-kit + cells resulted in expression of p53. Inhibition of p53 blocked cardiomyocyte differentiation in response to doxorubicin, whereas stabilization of p53 was sufficient to increase c-kit-derived cardiomyocyte differentiation. These results demonstrate that different pathological stimuli induce different cell fates of c-kit + cells in vivo. Although the overall rate of cardiomyocyte formation from c-kit + cells is still below clinically relevant levels, we show that p53 is central to the ability of c-kit + cells to adopt cardiomyocyte fates, which could lead to the development of strategies to preferentially generate cardiomyocytes from c-kit + cells. © 2017 American Heart Association, Inc.

  17. Isotope shifting capacity of rock

    International Nuclear Information System (INIS)

    Blattner, P.; Department of Scientific and Industrial Research, Lower Hutt

    1980-01-01

    Any oxygen isotope shifted rock volume exactly defines a past throughput of water. An expression is derived that relates the throughput of an open system to the isotope shift of reservoir rock and present-day output. The small isotope shift of Ngawha reservoir rock and the small, high delta oxygen-18 output are best accounted for by a magmatic water source

  18. Rock burst governance of working face under igneous rock

    Science.gov (United States)

    Chang, Zhenxing; Yu, Yue

    2017-01-01

    As a typical failure phenomenon, rock burst occurs in many mines. It can not only cause the working face to cease production, but also cause serious damage to production equipment, and even result in casualties. To explore how to govern rock burst of working face under igneous rock, the 10416 working face in some mine is taken as engineering background. The supports damaged extensively and rock burst took place when the working face advanced. This paper establishes the mechanical model and conducts theoretical analysis and calculation to predict the fracture and migration mechanism and energy release of the thick hard igneous rock above the working face, and to obtain the advancing distance of the working face when the igneous rock fractures and critical value of the energy when rock burst occurs. Based on the specific conditions of the mine, this paper put forward three kinds of governance measures, which are borehole pressure relief, coal seam water injection and blasting pressure relief.

  19. Uranium in alkaline rocks

    International Nuclear Information System (INIS)

    Murphy, M.; Wollenberg, H.; Strisower, B.; Bowman, H.; Flexser, S.; Carmichael, I.

    1978-04-01

    Geologic and geochemical criteria were developed for the occurrence of economic uranium deposits in alkaline igneous rocks. A literature search, a limited chemical analytical program, and visits to three prominent alkaline-rock localities (Ilimaussaq, Greenland; Pocos de Caldas, Brazil; and Powderhorn, Colorado) were made to establish criteria to determine if a site had some uranium resource potential. From the literature, four alkaline-intrusive occurrences of differing character were identified as type-localities for uranium mineralization, and the important aspects of these localities were described. These characteristics were used to categorize and evaluate U.S. occurrences. The literature search disclosed 69 U.S. sites, encompassing nepheline syenite, alkaline granite, and carbonatite. It was possible to compare two-thirds of these sites to the type localities. A ranking system identified ten of the sites as most likely to have uranium resource potential

  20. Rock solidification method

    International Nuclear Information System (INIS)

    Nakaya, Iwao; Murakami, Tadashi; Miyake, Takafumi; Funakoshi, Toshio; Inagaki, Yuzo; Hashimoto, Yasuhide.

    1985-01-01

    Purpose: To convert radioactive wastes into the final state for storage (artificial rocks) in a short period of time. Method: Radioactive burnable wastes such as spent papers, cloths and oils and activated carbons are burnt into ashes in a burning furnace, while radioactive liquid wastes such as liquid wastes of boric acid, exhausted cleaning water and decontaminating liquid wastes are powderized in a drying furnace or calcining furnace. These powders are joined with silicates as such as white clay, silica and glass powder and a liquid alkali such as NaOH or Ca(OH) 2 and transferred to a solidifying vessel. Then, the vessel is set to a hydrothermal reactor, heated and pressurized, then taken out about 20 min after and tightly sealed. In this way, radioactive wastes are converted through the hydrothermal reactions into aqueous rock stable for a long period of time to obtain solidification products insoluble to water and with an extremely low leaching rate. (Ikeda, J.)

  1. Uranium in alkaline rocks

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, M.; Wollenberg, H.; Strisower, B.; Bowman, H.; Flexser, S.; Carmichael, I.

    1978-04-01

    Geologic and geochemical criteria were developed for the occurrence of economic uranium deposits in alkaline igneous rocks. A literature search, a limited chemical analytical program, and visits to three prominent alkaline-rock localities (Ilimaussaq, Greenland; Pocos de Caldas, Brazil; and Powderhorn, Colorado) were made to establish criteria to determine if a site had some uranium resource potential. From the literature, four alkaline-intrusive occurrences of differing character were identified as type-localities for uranium mineralization, and the important aspects of these localities were described. These characteristics were used to categorize and evaluate U.S. occurrences. The literature search disclosed 69 U.S. sites, encompassing nepheline syenite, alkaline granite, and carbonatite. It was possible to compare two-thirds of these sites to the type localities. A ranking system identified ten of the sites as most likely to have uranium resource potential.

  2. Rock and mineral magnetism

    CERN Document Server

    O’Reilly, W

    1984-01-01

    The past two decades have witnessed a revolution in the earth sciences. The quantitative, instrument-based measurements and physical models of. geophysics, together with advances in technology, have radically transformed the way in which the Earth, and especially its crust, is described. The study of the magnetism of the rocks of the Earth's crust has played a major part in this transformation. Rocks, or more specifically their constituent magnetic minerals, can be regarded as a measuring instrument provided by nature, which can be employed in the service of the earth sciences. Thus magnetic minerals are a recording magnetometer; a goniometer or protractor, recording the directions of flows, fields and forces; a clock; a recording thermometer; a position recorder; astrain gauge; an instrument for geo­ logical surveying; a tracer in climatology and hydrology; a tool in petrology. No instrument is linear, or free from noise and systematic errors, and the performance of nature's instrument must be assessed and ...

  3. 76 FR 51037 - Determination That Halflytely and Bisacodyl Tablets Bowel Prep Kit (Containing Two Bisacodyl...

    Science.gov (United States)

    2011-08-17

    ... determined that Halflytely and Bisacodyl Tablets Bowel Prep Kit (polyethylene glycol (PEG) 3350, sodium... kits containing PEG-3350, sodium chloride, sodium bicarbonate, and potassium chloride for oral solution... that the Agency determine whether Halflytely and Bisacodyl Tablets Bowel Prep Kit (PEG- 3350, sodium...

  4. 33 CFR 149.323 - What are the requirements for first aid kits?

    Science.gov (United States)

    2010-07-01

    ... first aid kits? 149.323 Section 149.323 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Lifesaving Equipment Manned Deepwater Port Requirements § 149.323 What are the requirements for first aid kits? (a) Each manned deepwater port must have an industrial first aid kit, approved by an appropriate...

  5. [The comparison of two newborn cytomegalovirus IgG antibody screening ELISA kits].

    Science.gov (United States)

    Zhang, Shun-Xian; He, Xiao-Zhou; Wang, Shi-Wen; Wang, Xiao-Fang

    2013-10-01

    This study compared two newborn Cytomegalovirus (CMV) IgG antibody screening ELISA kits and evaluated the detection effectiveness of Abnova kit. CMV IgG antibodies were detected by both SeraQuest and Abnova kits from dried blood spot (DBS) samples of 488 newborn heel sticks. The detection abilities of these two kits were compared in different sample dilution concentrations. Relative detection effectiveness of the Abnova kit was defined by statistical method using the SeraQuest kit as a point of comparison. Compared to the SeraQuest screening test kit, the Abnova kit revealed a sensitivity of 98.9%, specificity of 78.6%, positive predictive value of 99.3%, negative predictive value of 68.8%, and the coincidence rate for these two screening test kits at 98.3%. The consistency check of both kits based on interpretation of the kappa statistic was relatively good. For the Abnova kit, the "area under the ROC curve" was 0.887, which indicates moderate accuracy. Abnova kit can be applied to newborn screening for congenital CMV infections. However, repeating the test for ambiguous results is suggested to increase the specificity and negative predictive value.

  6. 21 CFR 866.2480 - Quality control kit for culture media.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Quality control kit for culture media. 866.2480... control kit for culture media. (a) Identification. A quality control kit for culture media is a device...-dried, viable microorganism, intended for medical purposes to determine if a given culture medium is...

  7. Oncogenic activation of v-kit involves deletion of a putative tyrosine-substrate interaction site.

    Science.gov (United States)

    Herbst, R; Munemitsu, S; Ullrich, A

    1995-01-19

    The transforming gene of the Hardy-Zuckerman-4 strain of feline sarcoma virus, v-kit, arose by transduction of the cellular c-kit gene, which encodes the receptor tyrosine kinase (RTK) p145c-kit. To gain insight into the molecular basis of the v-kit transforming potential, we characterized the feline c-kit by cDNA cloning. Comparison of the feline v-kit and c-kit sequences revealed, in addition to deletions of the extracellular and transmembrane domains, three additional mutations in the v-kit oncogene product: deletion of tyrosine-569 and valine-570, the exchange of aspartate at position 761 to glycine, and replacement of the C-terminal 50 amino acids by five unrelated residues. Examinations of individual v-kit mutations in the context of chimeric receptors yielded inhibitory effects for some mutants on both autophosphorylation and substrate phosphorylation functions. In contrast, deletion of tyrosine-569 and valine-570 significantly enhanced transforming and mitogenic activities of p145c-kit, while the other mutations had no significant effects. Conservation in subclass III RTKs and the identification of the corresponding residue in beta PDGF-R, Y579, as a binding site for src family tyrosine kinases suggests an important role for Y568 in kit signal regulation and the definition of its oncogenic potential. Repositioning of Y571 by an inframe two codon deletion may be the crucial alteration resulting in enhancement of v-kit oncogenic activity.

  8. Aram Chaos Rocks

    Science.gov (United States)

    2005-01-01

    8 September 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows outcrops of light-toned, sedimentary rock among darker-toned mesas in Aram Chaos. Dark, windblown megaripples -- large ripples -- are also present at this location. Location near: 3.0oN, 21.6oW Image width: width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Autumn

  9. Deformations of fractured rock

    International Nuclear Information System (INIS)

    Stephansson, O.

    1977-09-01

    Results of the DBM and FEM analysis in this study indicate that a suitable rock mass for repository of radioactive waste should be moderately jointed (about 1 joint/m 2 ) and surrounded by shear zones of the first order. This allowes for a gentle and flexible deformation under tectonic stresses and prevent the development of large cross-cutting failures in the repository area. (author)

  10. Physical modeling of rock

    International Nuclear Information System (INIS)

    Cheney, J.A.

    1981-01-01

    The problems of statisfying similarity between a physical model and the prototype in rock wherein fissures and cracks place a role in physical behavior is explored. The need for models of large physical dimensions is explained but also testing of models of the same prototype over a wide range of scales is needed to ascertain the influence of lack of similitude of particular parameters between prototype and model. A large capacity centrifuge would be useful in that respect

  11. Rock disposal problems identified

    Energy Technology Data Exchange (ETDEWEB)

    Knox, R

    1978-06-01

    Mathematical models are the only way of examining the return of radioactivity from nuclear waste to the environment over long periods of time. Work in Britain has helped identify areas where more basic data is required, but initial results look very promising for final disposal of high level waste in hard rock repositories. A report by the National Radiological Protection Board of a recent study, is examined.

  12. An improved 99mTc-Aprotinin kit formulation: quality control analysis of cold kit shelf life and radiotracer stability

    International Nuclear Information System (INIS)

    Smyth, D.R.; Tsopelas, C.

    2005-01-01

    Aprotinin is a small protein that inhibits serine proteases and has been shown to bind to amyloid fibrils of varying chemical composition in-vitro. 99 mTc-aprotinin has demonstrated potential for imaging cardiac and pleuropulmonary AL amyloidosis and other forms of amyloidosis present as deposits in joints, the tongue or intestines and other sites excluding the kidneys and liver. Radiolabelling of aprotinin was previously achieved by addition of 99 mTc-pertech-netate to an alkaline mixture of Trasylol (aprotinin injection) and stannous chloride, followed by a necessary filtration step after 20-30 minutes. We have developed a modified cold kit formulation, utilising pharmaceutical starting materials, that provides a more convenient and efficient radiolabelling procedure where filtration is not required prior to injection. The shelf life of the cold kits was validated after storage in a freezer. The reducing agent used was stannous-pyrophosphate (PYP) and the alkaline buffer was a phosphate-glycine mixture (pH 10.5). Quality control testing of the cold kits was performed after 0, 1, 2, 3 and 6 months storage by assessing the % RCP of 99 mTc-apro-tinin by ITLC-SG. Radiotracer stability was examined in the same way 25, 85 and 265 minutes post reconstitution (pr) via a three strip system employing acetone, saline and ammonia:ethanol:water mixture (1:2:5). A rapid quality control cartridge method was also investigated. Radiolabelling of the cold kits yielded RCP > 95% at 25 mins pr and all other time points, from a formulation that avoided a filtration step. The impurities were quantified as TcO., ( 99 mTc-PYP (< 0.7%) by paper methods. The improved Tc-aprotinin kit formulation has greater convenience and efficiency in the clinical setting

  13. Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a.

    Directory of Open Access Journals (Sweden)

    Keith A Hultman

    2007-01-01

    Full Text Available The retention of particular genes after the whole genome duplication in zebrafish has given insights into how genes may evolve through partitioning of ancestral functions. We examine the partitioning of expression patterns and functions of two zebrafish kit ligands, kit ligand a (kitla and kit ligand b (kitlb, and discuss their possible coevolution with the duplicated zebrafish kit receptors (kita and kitb. In situ hybridizations show that kitla mRNA is expressed in the trunk adjacent to the notochord in the middle of each somite during stages of melanocyte migration and later expressed in the skin, when the receptor is required for melanocyte survival. kitla is also expressed in other regions complementary to kita receptor expression, including the pineal gland, tail bud, and ear. In contrast, kitlb mRNA is expressed in brain ventricles, ear, and cardinal vein plexus, in regions generally not complementary to either zebrafish kit receptor ortholog. However, like kitla, kitlb is expressed in the skin during stages consistent with melanocyte survival. Thus, it appears that kita and kitla have maintained congruent expression patterns, while kitb and kitlb have evolved divergent expression patterns. We demonstrate the interaction of kita and kitla by morpholino knockdown analysis. kitla morphants, but not kitlb morphants, phenocopy the null allele of kita, with defects for both melanocyte migration and survival. Furthermore, kitla morpholino, but not kitlb morpholino, interacts genetically with a sensitized allele of kita, confirming that kitla is the functional ligand to kita. Last, we examine kitla overexpression in embryos, which results in hyperpigmentation caused by an increase in the number and size of melanocytes. This hyperpigmentation is dependent on kita function. We conclude that following genome duplication, kita and kitla have maintained their receptor-ligand relationship, coevolved complementary expression patterns, and that

  14. Rock pushing and sampling under rocks on Mars

    Science.gov (United States)

    Moore, H.J.; Liebes, S.; Crouch, D.S.; Clark, L.V.

    1978-01-01

    Viking Lander 2 acquired samples on Mars from beneath two rocks, where living organisms and organic molecules would be protected from ultraviolet radiation. Selection of rocks to be moved was based on scientific and engineering considerations, including rock size, rock shape, burial depth, and location in a sample field. Rock locations and topography were established using the computerized interactive video-stereophotogrammetric system and plotted on vertical profiles and in plan view. Sampler commands were developed and tested on Earth using a full-size lander and surface mock-up. The use of power by the sampler motor correlates with rock movements, which were by plowing, skidding, and rolling. Provenance of the samples was determined by measurements and interpretation of pictures and positions of the sampler arm. Analytical results demonstrate that the samples were, in fact, from beneath the rocks. Results from the Gas Chromatograph-Mass Spectrometer of the Molecular Analysis experiment and the Gas Exchange instrument of the Biology experiment indicate that more adsorbed(?) water occurs in samples under rocks than in samples exposed to the sun. This is consistent with terrestrial arid environments, where more moisture occurs in near-surface soil un- der rocks than in surrounding soil because the net heat flow is toward the soil beneath the rock and the rock cap inhibits evaporation. Inorganic analyses show that samples of soil from under the rocks have significantly less iron than soil exposed to the sun. The scientific significance of analyses of samples under the rocks is only partly evaluated, but some facts are clear. Detectable quantities of martian organic molecules were not found in the sample from under a rock by the Molecular Analysis experiment. The Biology experiments did not find definitive evidence for Earth-like living organisms in their sample. Significant amounts of adsorbed water may be present in the martian regolith. The response of the soil

  15. The Rock Characterization Facility

    International Nuclear Information System (INIS)

    Holmes, J.

    1994-01-01

    In 1989, UK Nirex began a programme of surface-based characterization of the geology and hydrogeology of a site at Sellafield to evaluate its suitability to host a deep repository for radioactive waste. The next major stage in site characterization will be the construction and operation of a Rock Characterization Facility (RCF). It will be designed to provide rock characterization information and scope for model validation to permit firmer assessment of long-term safety. It will also provide information needed to decide the detailed location, design and orientation of a repository and to inform repository construction methods. A three-phase programme is planned for the RCF. During each phase, testwork will steadily improve our geological, hydrogeological and geotechnical understanding of the site. The first phase will involve sinking two shafts. That will be preceded by the establishment of a network of monitoring boreholes to ensure that the impact of shaft sinking can be measured. This will provide valuable data for model validation. In phase two, initial galleries will be excavated, probably at a depth of 650 m below Ordnance datum, which will host a comprehensive suite of experiments. These galleries will be extended in phase three to permit access to most of the rock volume that would host the repository. (Author)

  16. Scattering from Rock and Rock Outcrops

    Science.gov (United States)

    2018-01-23

    provide such an estimate of the joint probability distribution of mixture model parameters. The posterior probability distribution ( PPD ) of the model...parameters given the data is p(m,d), where m is a four component vector of model param- eters, and d is an n component vector of data points. The PPD ...distribution of the data p(d). The evidence normalizes the numerator in Eq. (10) and ensures that the PPD integrates to unity over the parameter space. The

  17. Rock in Rio: forever young

    Directory of Open Access Journals (Sweden)

    Ricardo Ferreira Freitas

    2014-12-01

    Full Text Available The purpose of this article is to discuss the role of Rock in Rio: The Musical, as herald of megafestival Rock in Rio. Driven by the success that musicals have reached in Brazil, we believe that the design of this spectacle of music, dance and staging renews the brand of the rock festival, once it adds the force of young and healthy bodies to its concept. Moreover, the musical provides Rock in Rio with some distance from the controversal trilogy of sex, drugs and rock and roll, a strong mark of past festivals around the world. Thus, the musical expands the possibilities of growth for the brand.

  18. Development of artificial soft rock

    International Nuclear Information System (INIS)

    Kishi, Kiyoshi

    1995-01-01

    When foundation base rocks are deeper than the level of installing structures or there exist weathered rocks and crushed rocks in a part of base rocks, often sound artificial base rocks are made by substituting the part with concrete. But in the construction of Kashiwazaki Kariwa Nuclear Power Station of Tokyo Electric Power Co., Inc., the foundation base rocks consist of mudstone, and the stiffness of concrete is large as compared with the surrounding base rocks. As the quality of the substituting material, the nearly same stiffness as that of the surrounding soft rocks and long term stability are suitable, and the excellent workability and economical efficiency are required, therefore, artificial soft rocks were developed. As the substituting material, the soil mortar that can obtain the physical property values in stable form, which are similar to those of Nishiyama mudstone, was selected. The mechanism of its hardening and the long term stability, and the manufacturing plant are reported. As for its application to the base rocks of Kashiwazaki Kariwa Nuclear Power Station, the verification test at the site and the application to the base rocks for No. 7 plant reactor building and other places are described. (K.I.)

  19. Hydrological characteristics of Japanese rock

    International Nuclear Information System (INIS)

    Ijiri, Yuji; Sawada, Atsushi; Akahori, Kuniaki

    1999-11-01

    It is crucial to evaluate the hydrogeological characteristics of rock in Japan in order to assess the performance of geosphere. This report summarizes the hydrogeological characteristics of various rock types obtained from broad literature surveys and the fields experiments at the Kamaishi mine in northern Japan and at the Tono mine in central Japan. It is found that the hydraulic conductivity of rock mass ranges from 10 -9 m/s to 10 -8 m/s, whereas the hydraulic conductivity of fault zone ranges from 10 -9 m/s to 10 -3 m/s. It is also found that the hydraulic conductivity tends to decrease with depth. Therefore, the hydraulic conductivity of rock mass at the depth of a repository will be smaller than above values. From the investigations at outcrops and galleries throughout the country, fractures are observed as potential pathways in all rock types. All kinds of crystalline rocks and pre-Neogene sedimentary rocks are classified as fractured media where fracture flow is dominant. Among these rocks, granitic rock is considered the archetype fractured media. On the other hand, andesite, tuff and Neogene sedimentary rocks are considered as intermediate between fractured media and porous media where flow in fractures as well as in rock matrix are significant. (author)

  20. Developing a Ballistic Software Kit to Estimate Vehicle Characteristics at the Draft Design Stage

    Directory of Open Access Journals (Sweden)

    V. I. Maiorova

    2015-01-01

    Full Text Available The article describes a ballistic software kit to calculate a moving vehicle trajectory in atmosphere and space. Such software gives an opportunity to accelerate the acquisition of flying vehicle’s ballistic parameters at the stage of draft design. It contributes to improving collaboration efficiency between adjacent departments involved in the project. The developed software kit includes three different programs: Trajectory-LAND© (motion in atmosphere with possible correction of a trajectory, Trajectory-SPACE© (motion in the non-central gravity field with possible simulation of maneuvers, Trajectory-LAUNCH© (launch-vehicle’s insertion into the orbit with possible defining the impact points of separated stages. Each of the software concedes the addition of computational modules to use the solution results of the basic task. Implemented mathematical models permit to take into account the influence of main perturbations on the flying vehicle during the flight. For illustration purposes, the article gives some examples of using each of the programs and their block-diagrams.The developed software implements some algorithms, which allow attaining the convergence of numerical simulation of differential equations of motion. This problem arises, for example, while determining an attitude in case the stages have already separated from the launch vehicle. The mathematical conversion from Rodriguez-Hamilton parameters into Euler’s angles disables us to obtain reliable values of attitude angles due to the limitations for existing area of inverse trigonometric functions being used. Incorrect values of pitch lead to raw and roll channels divergences. Moreover, the mistakes in attitude determination lead to mistakes in obtained values of attack angle, which is included into the forms for aerodynamic forces and torques. As a result, the solution of system of differential equations is a failure when a flying vehicle enters the height of 30-35 km. The

  1. Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.

    Science.gov (United States)

    Reith, A D; Ellis, C; Lyman, S D; Anderson, D M; Williams, D E; Bernstein, A; Pawson, T

    1991-09-01

    Germline mutations at the Dominant White Spotting (W) and Steel (Sl) loci have provided conclusive genetic evidence that c-kit mediated signal transduction pathways are essential for normal mouse development. We have analysed the interactions of normal and mutant W/c-kit gene products with cytoplasmic signalling proteins, using transient c-kit expression assays in COS cells. In addition to the previously identified c-kit gene product (Kit+), a second normal Kit isoform (KitA+) containing an in-frame insertion, Gly-Asn-Asn-Lys, within the extracellular domain, was detected in murine mast cell cultures and mid-gestation placenta. Both Kit+ and KitA+ isoforms showed increased autophosphorylation and enhanced association with phosphatidylinositol (PI) 3' kinase and PLC gamma 1, when stimulated with recombinant soluble Steel factor. No association or increase in phosphorylation of GAP and two GAP-associated proteins, p62 and p190, was observed. The two isoforms had distinct activities in the absence of exogenous soluble Steel factor; Kit+, but not KitA+, showed constitutive tyrosine phosphorylation that was accompanied by a low constitutive level of association with PI-3' kinase and PLC gamma 1. Introduction of the point substitutions associated with W37 (Glu582----Lys) or W41 (Val831----Met) mutant alleles into c-kit expression constructs abolished (W37) or reduced (W41) the Steel factor-induced association of the Kit receptor with signalling proteins in a manner proportional to the overall severity of the corresponding W mutant phenotype. These data suggest a diversity of normal Kit signalling pathways and indicate that W mutant phenotypes result from primary defects in the Kit receptor that affect its interaction with cytoplasmic signalling proteins.

  2. A new design concept of fully grouted rock bolts in underground construction

    Science.gov (United States)

    Phich Nguyen, Quang; Nguyen, Van Manh; Tuong Nguyen, Ke

    2018-04-01

    The main problem after excavating an underground excavation is to maintain the stability of the excavation for a certain period of time. Failure in meeting this demand is a threat to safety of men and equipment. Support and reinforcement are different instruments with different mechanisms. Among the common support systems in tunnelling and mining, rock bolts have been widely used to reinforce rock mass and also to reduce geological hazards. Furthermore rock bolts can be applied under varying different geological conditions with cost-effectiveness. Although different methods are developed for grouted rock bolts design until now, the interaction mechanism of the rock bolts and rock mass is still very complicated issue. The paper addresses an analytical model for the analysis and design of fully grouted rock bolts based on the reinforcement principle. According to this concept the jointed rock mass reinforced by grouted rock bolts is considered as composite material which includes rock mass, the grout material and the bolt shank. The mechanical properties of this composite material depend on the ratio of the components. The closed-form solution was developed based on the assumption that the rock mass arround a circular tunnel remained elastic after installing fully grouted rock bolts. The main parameters of the rock-bolt system (the diameter and length of bolt shank, the space between the bolts) are then easily estimated from the obtained solution.

  3. Grinding into Soft, Powdery Rock

    Science.gov (United States)

    2004-01-01

    This hole in a rock dubbed 'Clovis' is the deepest hole drilled so far in any rock on Mars. NASA's Mars Exploration Rover Spirit captured this view with its microscopic imager on martian sol 217 (Aug. 12, 2004) after drilling 8.9 millimeters (0.35 inch) into the rock with its rock abrasion tool. The view is a mosaic of four frames taken by the microscopic imager. The hole is 4.5 centimeters (1.8 inches) in diameter. Clovis is key to a developing story about environmental change on Mars, not only because it is among the softest rocks encountered so far in Gusev Crater, but also because it contains mineral alterations that extend relatively deep beneath its surface. In fact, as evidenced by its fairly crumbly texture, it is possibly the most highly altered volcanic rock ever studied on Mars. Scientific analysis shows that the rock contains higher levels of the elements sulfur, chlorine, and bromine than are normally encountered in basaltic rocks, such as a rock dubbed 'Humphrey' that Spirit encountered two months after arriving on Mars. Humphrey showed elevated levels of sulfur, chlorine, and bromine only in the outermost 2 millimeters (less than 0.1 inch) of its surface. Clovis shows elevated levels of the same elements along with the associated softness of the rock within a borehole that is 4 times as deep. Scientists hope to compare Clovis to other, less-altered rocks in the vicinity to assess what sort of water-based processes altered the rock. Hypotheses include transport of sulfur, chlorine, and bromine in water vapor in volcanic gases; hydrothermal circulation (flow of volcanically heated water through rock); or saturation in a briny soup containing the same elements. In this image, very fine-grained material from the rock has clumped together by electrostatic attraction and fallen into the borehole. NASA/JPL/Cornell/USGS

  4. Discovery of amido-benzisoxazoles as potent c-Kit inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Kunz, Roxanne K.; Rumfelt, Shannon; Chen, Ning; Zhang, Dawei; Tasker, Andrew S.; Bürli, Roland; Hungate, Randall; Yu, Violeta; Nguyen, Yen; Whittington, Douglas A.; Meagher, Kristin L.; Plant, Matthew; Tudor, Yanyan; Schrag, Michael; Xu, Yang; Ng, Gordon Y.; Hu, Essa (Amgen)

    2010-01-12

    Deregulation of the receptor tyrosine kinase c-Kit is associated with an increasing number of human diseases, including certain cancers and mast cell diseases. Interference of c-Kit signaling with multi-kinase inhibitors has been shown clinically to successfully treat gastrointestinal stromal tumors and mastocytosis. Targeted therapy of c-Kit activity may provide therapeutic advantages against off-target effects for non-oncology applications. A new structural class of c-Kit inhibitors is described, including in vitro c-Kit potency, kinase selectivity, and the observed binding mode.

  5. 3D vision upgrade kit for TALON robot

    Science.gov (United States)

    Edmondson, Richard; Vaden, Justin; Hyatt, Brian; Morris, James; Pezzaniti, J. Larry; Chenault, David B.; Tchon, Joe; Barnidge, Tracy; Kaufman, Seth; Pettijohn, Brad

    2010-04-01

    In this paper, we report on the development of a 3D vision field upgrade kit for TALON robot consisting of a replacement flat panel stereoscopic display, and multiple stereo camera systems. An assessment of the system's use for robotic driving, manipulation, and surveillance operations was conducted. The 3D vision system was integrated onto a TALON IV Robot and Operator Control Unit (OCU) such that stock components could be electrically disconnected and removed, and upgrade components coupled directly to the mounting and electrical connections. A replacement display, replacement mast camera with zoom, auto-focus, and variable convergence, and a replacement gripper camera with fixed focus and zoom comprise the upgrade kit. The stereo mast camera allows for improved driving and situational awareness as well as scene survey. The stereo gripper camera allows for improved manipulation in typical TALON missions.

  6. Optimization and Validation of kit of detection Antibiotics on Honey

    International Nuclear Information System (INIS)

    Hamza, Malek

    2013-01-01

    According to the Codex Alimentarius and the European Commission Directive each food has a maximum residual antibiotic (MRLs) however, for honey is still no limit set. Among the main methods that guarantee the detection of antibiotic residues include the Premi Test which is a qualitative method for the detection of antibiotics in honey, but it remains a non-specific method for this matrix and long enough (three hours of incubation). Through this work, we were able to develop and optimize a new kit called Honey test. This kit is able to detect the presence of antibiotic residues in honey by a bacterial strain radio-resistant called D.ra. The duration of treatment is only 30 minutes, requiring incubation at 37 Degree C and treatment with UV at 366 nm. This work will be the subject of a national patent.

  7. DogMATIC--A Remote Biospecimen Collection Kit for Biobanking.

    Science.gov (United States)

    Milley, Kristi M; Nimmo, Judith S; Bacci, Barbara; Ryan, Stewart D; Richardson, Samantha J; Danks, Janine A

    2015-08-01

    Canine tumors are valuable comparative oncology models. This research was designed to create a sustainable biobank of canine mammary tumors for breast cancer research. The aim was to provide a well-characterized sample cohort for specimen sharing, data mining, and long-term research aims. Canine mammary tumors are most frequently managed at a local veterinary clinic or hospital. We adopted a biobank framework based on a large number of participating veterinary hospitals and clinics acting as collection centers that were serviced by a centralized storage facility. Recruitment was targeted at rural veterinary clinics. A tailored, stable collection kit (DogMATIC) was designed that was used by veterinarians in remote or rural locations to collect both fresh and fixed tissue for submission to the biobank. To validate this methodology the kit design, collection rate, and sample quality were analyzed. The Australian Veterinary Cancer Biobank was established as a network of 47 veterinary clinics and three veterinary pathology laboratories spanning over 200,000 km(2). In the first 12 months, 30 canine mammary tumor cases were submitted via the DogMATIC kit. Pure intact RNA was isolated in over 80% of samples with an average yield of 14.49 μg. A large network biobank, utilizing off-site collection with the DogMATIC kit, was successfully coordinated. The creation of the Australian Veterinary Cancer Biobank has established a long-term, sustainable, comparative oncology research resource in Australia. There are broader implications for biobanking with this very different form of collection and banking.

  8. Physicochemical characteristics of the kanamycin-lyophilized kit

    International Nuclear Information System (INIS)

    Eva Maria Widyasari; Misyetti; Teguh Hafiz Ambar W; Witri Nuraeni

    2013-01-01

    Kanamycin is a broad-spectrum antibiotic and usually used for the treatment of infections when antibiotics like penicillin are less powerful and can not be given. This research was performed to obtain several physicochemical character of 99m Tc-kanamycin which were made in the form of lyophilized kanamycin kit to ensure the later application in humans. Kanamycin diagnostic kit were provided in lyophilized kit comprising kanamycin as ligand compound, pyrophosphate as co-ligand and SnCl 2 as reducing agent. The radiochemical purity was determined by instant thin layer chromatography (ITLC-SG) using 0.5 N NaOH as the mobile phase and ascending paper chromatography using Whatman paper 3 with acetone as the mobile phase. The plasma binding protein of 99m Tc-kanamycin was investigated in vitro by precipitation method using 5% of trichloro acetic acid (TCA) solution, whereas the lipophilicity (log P) was obtained by determination the partition coefficient in organic solvent-water system. Studies on the effect of the amount of radioactivity and the volume of Na 99m TcO 4 solution to the radiochemical purity of 99m Tc-kanamycin were also performed. From this experiment it was obtained that kanamycin lyophilized-kit was hydrophilic, 59.54% of solutions bound to plasma, radiochemical purity was more than 95%, and the final volume of 2 ml dosage was stable up to 2 hours after the addition of 99m Tc with a radioactivity of less then 3 mCi. (author)

  9. Feasibility of fractionating MIBI cold kits for cost reduction

    Energy Technology Data Exchange (ETDEWEB)

    Penglis, S.; Tsopelas, C. [Royal Adelaide Hospital. SA (Australia)

    1998-06-01

    Full text: Recently {sup 99m}Tc-MIBI become the first 99mTc-labelled myocardial perfusion imaging agent commercially available in Australia. After labelling each vial is sufficient for three to four patient doses. However, it becomes very expensive when only a single patient dose is required (up to $350 per dose). Our goal in this study was to subdivide the MIBI kit into fractions to establish the stability of these split kits. If successful, this would reduce the expense and make the product more cost-effective. After dissolving the Iyophilised ingredients of a MIBI vial with 5 mL of N2-purged normal saline, 1 mL aliquots of the resultant solution were dispensed into N2-filled vials under aseptic conditions. The vials were then stored frozen at -70 deg C. 99mTc-MIBI was prepared by the addition of 2 GBq of {sup 99m}Tc-pertechnetate in I mL of normal saline to the fractionated kit, followed by heating at 100 deg C for 10 minutes at 0, 2, 4 and 8 weeks post-fractionation. The product was allowed to cool before testing for radiochemical purity (RCP) for up to six hours post-labelling. The RCP of each vial was determined using aluminium oxide coated aluminium TLC strips (Merck) run in 100% ethanol. Over the eight-week evaluation period RCP was maintained at 94.2 + 1.3% over six hours (n = 16), which is greater than the minimum recommended RCP (90%) for patient use. These results show that fractionation of MIBI cold kits and sub-frozen storage under an N{sub 2} atmosphere provides a stable and economical multidose product. Using this method the cost of a single patient dose can be reduced considerably from $350, even allowing for the labour involved in the fractionation

  10. Feasibility of fractionating MIBI cold kits for cost reduction

    International Nuclear Information System (INIS)

    Penglis, S.; Tsopelas, C.

    1998-01-01

    Full text: Recently 99m Tc-MIBI become the first 99mTc-labelled myocardial perfusion imaging agent commercially available in Australia. After labelling each vial is sufficient for three to four patient doses. However, it becomes very expensive when only a single patient dose is required (up to $350 per dose). Our goal in this study was to subdivide the MIBI kit into fractions to establish the stability of these split kits. If successful, this would reduce the expense and make the product more cost-effective. After dissolving the Iyophilised ingredients of a MIBI vial with 5 mL of N2-purged normal saline, 1 mL aliquots of the resultant solution were dispensed into N2-filled vials under aseptic conditions. The vials were then stored frozen at -70 deg C. 99mTc-MIBI was prepared by the addition of 2 GBq of 99m Tc-pertechnetate in I mL of normal saline to the fractionated kit, followed by heating at 100 deg C for 10 minutes at 0, 2, 4 and 8 weeks post-fractionation. The product was allowed to cool before testing for radiochemical purity (RCP) for up to six hours post-labelling. The RCP of each vial was determined using aluminium oxide coated aluminium TLC strips (Merck) run in 100% ethanol. Over the eight-week evaluation period RCP was maintained at 94.2 + 1.3% over six hours (n = 16), which is greater than the minimum recommended RCP (90%) for patient use. These results show that fractionation of MIBI cold kits and sub-frozen storage under an N 2 atmosphere provides a stable and economical multidose product. Using this method the cost of a single patient dose can be reduced considerably from $350, even allowing for the labour involved in the fractionation

  11. Pharmacists' views on and experiences with bowel cancer screening kits in Auckland, New Zealand.

    Science.gov (United States)

    Martini, Nataly; Basdew, Kamlika; Kammona, Ala; Shen, Amy; Taylor, Caragh; McIntosh, Timothy R; Barnes, Joanne

    2014-08-01

    To explore the views of New Zealand pharmacists on bowel cancer screening, particularly with regards to faecal occult blood testing (FOBT) kits, self-perceived knowledge on FOBT kits and barriers, motivators and experiences with selling and counselling consumers with respect to FOBT kits. Semi-structured interviews were conducted face to face or by telephone with 20 community pharmacists in the Auckland region. Interviews were recorded and transcribed verbatim and data were coded and analysed using NVivo software to identify key themes. Participant pharmacists believed that they were well placed to provide advice on FOBT kits to consumers. Barriers to selling the kits included cost and perceived lack of test sensitivity of the kits, poor consumer demand, pharmacists' lack of training and information, and a belief that selling FOBT kits was outside the pharmacists' scope of practice. Motivators to selling the kits included customer convenience, ease of use, confidence in the kits and embracing new roles for pharmacists. Pharmacists were concerned that use of the kits may increase the burden on the public health system through customer anxiety over test results; however, they agreed that there was a need for bowel cancer screening and awareness and that people concerned about bowel cancer should make visiting their general practitioner a priority. Pharmacists' views were mixed. Pharmacists' training and competence with respect to the provision of bowel cancer kits, and how a bowel cancer screening service can be developed to optimise public health outcomes, need to be addressed. © 2013 Royal Pharmaceutical Society.

  12. Rock mechanics for hard rock nuclear waste repositories

    International Nuclear Information System (INIS)

    Heuze, F.E.

    1981-09-01

    The mined geologic burial of high level nuclear waste is now the favored option for disposal. The US National Waste Terminal Storage Program designed to achieve this disposal includes an extensive rock mechanics component related to the design of the wastes repositories. The plan currently considers five candidate rock types. This paper deals with the three hard rocks among them: basalt, granite, and tuff. Their behavior is governed by geological discontinuities. Salt and shale, which exhibit behavior closer to that of a continuum, are not considered here. This paper discusses both the generic rock mechanics R and D, which are required for repository design, as well as examples of projects related to hard rock waste storage. The examples include programs in basalt (Hanford/Washington), in granitic rocks (Climax/Nevada Test Site, Idaho Springs/Colorado, Pinawa/Canada, Oracle/Arizona, and Stripa/Sweden), and in tuff

  13. Example of fracture characterization in granitic rock

    International Nuclear Information System (INIS)

    Thorpe, R.K.

    1981-03-01

    A detailed study of geologic discontinuities for an underground heater test in highly fractured granitic rock is reported. Several prominent shear fractures were delineated within a 6 x 30 x 15 m rock mass by correlating surface mapping and borehole fracture logs. Oblique-reverse faulting is suspected on at least one of the surfaces, and its inferred borehole intercepts appear to be collinear in the direction of slickensiding observed in the field. Four distinct joint sets were identified, one of which coincides with the shear fractures. Another lies nearly horizontal, and two others are steeply inclined and orthogonal. Fracture lengths and spacings for the four joint sets are represented by lognormal probability distributions

  14. Formulation of MIBI Kit as a heart imaging agent

    International Nuclear Information System (INIS)

    Widyastuti; A, Hanafiah; Yunilda; A, Laksmi; Setyowati, Sri; Y Veronika

    1999-01-01

    9 9 m Tc labelled 2-methoxy-isobutyl-isonitrile(MIBI) has been known as an imaging agent for myocardial perfusion. This radiopharmaceutical preparation gives the same satisfactory result as Thallium- 2 10TI, and presumably could replace 2 01TI because of same advantages. MIBI kit was formulated from MIBI ligand produced by RPC-BATAN which has been characterized and tested for quality. The formula used in this research referred to the formula of imported product(Cardiolite, MIBI kit produced by Dupont), and the quality control testing was performed by comparing some parameters to the imported product. The parameters used for QC testing were radiochemical purity, biodistribution in nice and heart imaging in human volunteer using gamma camera. The result of the experiment showed that the radiochemical purity was 95 % in average, biodistribution in heart to liver gave the ratio of 0.67, 1.5, and 2.53 respectively at 10, 30 and 60 minutes after injection. The result of clinical testing in some volunteers gave contrast images as good as given by Cardiolite. The optimum condition of freeze drying has been found, and the kit can be used for more than 6 months

  15. Basic and clinical investigation of T3 immunoassay kit

    International Nuclear Information System (INIS)

    Konishi, Junji; Nakajima, Akiko; Morita, Rikushi; Endo, Keigo; Ikekubo, Katsuji

    1976-01-01

    T 3 immunoassay kit was investigated basically and clinically. A good result was obtained at the prescribed incubation temperature and for 16 hours of incubation time. Moreover, it was thought to be possible that incubation time could be shortened to 1 - 4 hours at 37 0 C. Specificity of antibody was good. Recovery of added T 3 was 100+-5 (S.D.) % on an average and parallel of dilution curve of high T 3 serum was also good. Variation coefficient of accuracy of this kit was 1.5 - 2.1 % and that of reproducibility was 1.3 - 6.6 %. Mild hemolysis did not affect measurement value. Serum T 3 level in normals, untreated patients with Basedow's disease and patients with primary hypothyroidism was 142+-21 ng/100 ml, 452+-156 ng/100 ml and 67+-17 ng/100 ml, respectively. Serum T 3 level in patients with Hashimoto's disease was distributed to a wide extent, but that of patients with goiter and simple goiter ranged within normal range. On the other side, serum T 3 level of normal pregnant woman was high and that of patients with anorexia nervosa showed low level. From the above mentioned results, it was concluded that this kit was simple in method and good in sensitivity, specificity and reproducibility and it was also useful for clinical applications. (M. Tsunoda)

  16. Fabrication of CANFLEX bundle kit for irradiation test in NRU

    International Nuclear Information System (INIS)

    Cho, Moon Sung; Kwon, Hyuk Il; Ji, Chul Goo; Chang, Ho Il; Sim, Ki Seob; Suk, Ho Chun.

    1997-10-01

    CANFLEX bundle kit was prepared at KAERI for the fabrication of complete bundle at AECL. Completed bundle will be used for irradiation test in NRU. Provisions in the 'Quality Assurance Manual for HWR Fuel Projects,' 'Manufacturing Plan' and 'Quality Verification, Inspection and Test Plan' were implemented as appropriately for the preparation of CANFLEX kit. A set of CANFLEX kit consist of 43 fuel sheath of two different sizes with spacers, bearing pads and buttons attached, 2 pieces of end plates and 86 pieces of end caps with two different sizes. All the documents utilized as references for the fabrication such as drawings, specifications, operating instructions, QC instructions and supplier's certificates are specified in this report. Especially, suppliers' certificates and inspection reports for the purchased material as well as KAERI's inspection report are integrated as attachments to this report. Attached to this report are supplier's certificates and KAERI inspection reports for the procured materials and KAERI QC inspection reports for tubes, pads, spacers, buttons, end caps, end plates and fuel sheath. (author). 37 refs

  17. 2MASS Catalog Server Kit Version 2.1

    Science.gov (United States)

    Yamauchi, C.

    2013-10-01

    The 2MASS Catalog Server Kit is open source software for use in easily constructing a high performance search server for important astronomical catalogs. This software utilizes the open source RDBMS PostgreSQL, therefore, any users can setup the database on their local computers by following step-by-step installation guide. The kit provides highly optimized stored functions for positional searchs similar to SDSS SkyServer. Together with these, the powerful SQL environment of PostgreSQL will meet various user's demands. We released 2MASS Catalog Server Kit version 2.1 in 2012 May, which supports the latest WISE All-Sky catalog (563,921,584 rows) and 9 major all-sky catalogs. Local databases are often indispensable for observatories with unstable or narrow-band networks or severe use, such as retrieving large numbers of records within a small period of time. This software is the best for such purposes, and increasing supported catalogs and improvements of version 2.1 can cover a wider range of applications including advanced calibration system, scientific studies using complicated SQL queries, etc. Official page: http://www.ir.isas.jaxa.jp/~cyamauch/2masskit/

  18. Kit development for labelling erythrocytes or leukocytes with technetium-99m in vitro

    International Nuclear Information System (INIS)

    Wang Xuebin; Han Quansheng; Wang Jingcheng; Mi Hongzhi

    1996-01-01

    This study developed a modified pre tinning method for labeling erythrocytes with technetium-99m in vitro using a kit which contains stannous chloride stabilized with geneticist acid (GA) in lyophilized form. This GA-kit a sterile closed system that does not require centrifugation,washing and separation of the RBCs. The kit is simple to use and labeling takes ∼ 30 min with a typical labeling efficiency of 97.3% ± 1.2% for 60 determinations. Imaging studies were performed in rabbit using GA-kit in vitro labeling procedure and PYP-kit in vivo labeling. It shows that the heart-to-background ratio with GA in vitro labeling were significantly higher than with in vivo labeling. Leukocytes labeling with technetium-99m using the same GA kit also was studied. The labeling efficiency was 20 ∼ 41%. Thus, the GA kit is versatile and cost-effective. (author). 21 refs., 5 figs., 2 tabs

  19. Rock stress investigations

    International Nuclear Information System (INIS)

    Pahl, A.; Heusermann, St.; Braeuer, V.; Gloeggler, W.

    1989-04-01

    On the research project 'Rock Stress Mesurements' the BGR has developed and tested several methods for use in boreholes at a depth of 200 m. Indirect stress measurements using overcoring methods with BGR-probes and CSIR-triaxial cells as well as direct stress measurements using the hydraulic-fracturing method were made. To determine in-situ rock deformation behavior borehole deformation tests, using a BGR-dilatometer, were performed. Two types of the BGR-probe were applied: a four-component-probe to determine horizontal stresses and a five-component-probe to determine a quasi three-dimensional stress field. The first time a computer for data processing was installed in the borehole together with the BGR-probe. Laboratory tests on low cylinders were made to study the stress-deformation behavior. To validate and to interprete the measurement results some test methods were modelled using the finite-element method. The dilatometer-tests yielded high values of Young's modulus, whereas laboratory tests showed lower values with a distinct deformation anisotropy. Stress measurements with the BGR-probe yielded horizontal stresses being higher than the theoretical overburden pressure. These results are comparable to the results of the hydraulic fracturing tests, whereas stresses obtained with CSIR-triaxial cells are lower. The detailed geological mapping of the borehole indicated relationships between stress and geology. With regard to borehole depth different zones of rock structure joint frequency, joint orientation, and orientation of microfissures as well as stress magnitude, stress direction, and degree of deformation anisotropy could be distinguished. (author) 4 tabs., 76 figs., 31 refs

  20. Development of positron emission tomography probe of 64Cu-labeled anti-C-kit 12A8 Fab to measure protooncogene C-kit expression

    International Nuclear Information System (INIS)

    Yoshida, Chisato; Tsuji, Atsushi B.; Sudo, Hitomi; Sugyo, Aya; Sogawa, Chizuru; Inubushi, Masayuki; Uehara, Tomoya; Fukumura, Toshimitsu; Koizumi, Mitsuru; Arano, Yasushi; Saga, Tsuneo

    2011-01-01

    Introduction: C-kit is an important diagnostic and therapeutic target molecule for several malignancies, and c-kit-targeted drugs have been used clinically. Because abundant c-kit expression in tumors is a prerequisite for successful c-kit-targeted therapy, imaging of c-kit expression is expected to play a pivotal role in the therapeutic decision for each patient. We evaluated 64 Cu-labeled Fab of anti-c-kit antibody 12A8 as a positron emission tomography (PET) imaging probe. Methods: 111 In- or 125 I-Labeled 12A8 Fab was evaluated in vitro by cell binding, competitive inhibition and cellular internalization assays, and in vivo by biodistribution in mice bearing c-kit-expressing and -non-expressing tumors. Next, Fab fragment was labeled with the positron emitter 64 Cu and evaluated by PET. Results: Radiolabeled 12A8 Fab showed specific binding to c-kit-expressing cells with high affinity and internalized into cells after binding to c-kit on cell surface. Although tumor accumulation of [ 111 In]Fab was lower than that of [ 111 In]IgG, the faster blood clearance of [ 111 In]Fab provided higher tumor-to-blood ratio at 6 h postinjection onwards. Blood clearance of 64 Cu-labeled 12A8 Fab was slower than that of [ 111 In]Fab, but PET using [ 64 Cu]Fab clearly visualized the tumor at 6 h postinjection onwards. Conclusion: The 64 Cu-labeled 12A8 Fab could be used for c-kit-specific PET imaging and might help in selecting appropriate patients for c-kit-targeted treatments.

  1. Use of an adaptable cell culture kit for performing lymphocyte and monocyte cell cultures in microgravity

    Science.gov (United States)

    Hatton, J. P.; Lewis, M. L.; Roquefeuil, S. B.; Chaput, D.; Cazenave, J. P.; Schmitt, D. A.

    1998-01-01

    The results of experiments performed in recent years on board facilities such as the Space Shuttle/Spacelab have demonstrated that many cell systems, ranging from simple bacteria to mammalian cells, are sensitive to the microgravity environment, suggesting gravity affects fundamental cellular processes. However, performing well-controlled experiments aboard spacecraft offers unique challenges to the cell biologist. Although systems such as the European 'Biorack' provide generic experiment facilities including an incubator, on-board 1-g reference centrifuge, and contained area for manipulations, the experimenter must still establish a system for performing cell culture experiments that is compatible with the constraints of spaceflight. Two different cell culture kits developed by the French Space Agency, CNES, were recently used to perform a series of experiments during four flights of the 'Biorack' facility aboard the Space Shuttle. The first unit, Generic Cell Activation Kit 1 (GCAK-1), contains six separate culture units per cassette, each consisting of a culture chamber, activator chamber, filtration system (permitting separation of cells from supernatant in-flight), injection port, and supernatant collection chamber. The second unit (GCAK-2) also contains six separate culture units, including a culture, activator, and fixation chambers. Both hardware units permit relatively complex cell culture manipulations without extensive use of spacecraft resources (crew time, volume, mass, power), or the need for excessive safety measures. Possible operations include stimulation of cultures with activators, separation of cells from supernatant, fixation/lysis, manipulation of radiolabelled reagents, and medium exchange. Investigations performed aboard the Space Shuttle in six different experiments used Jurkat, purified T-cells or U937 cells, the results of which are reported separately. We report here the behaviour of Jurkat and U937 cells in the GCAK hardware in ground

  2. A smart rock

    Science.gov (United States)

    Pressel, Phil

    2014-12-01

    This project was to design and build a protective weapon for a group of associations that believed in aliens and UFO's. They collected enough contributions from societies and individuals to be able to sponsor and totally fund the design, fabrication and testing of this equipment. The location of this facility is classified. It also eventually was redesigned by the Quartus Engineering Company for use at a major amusement park as a "shoot at targets facility." The challenge of this project was to design a "smart rock," namely an infrared bullet (the size of a gallon can of paint) that could be shot from the ground to intercept a UFO or any incoming suspicious item heading towards the earth. Some of the challenges to design this weapon were to feed cryogenic helium at 5 degrees Kelvin from an inair environment through a unique rotary coupling and air-vacuum seal while spinning the bullet at 1500 rpm and maintain its dynamic stability (wobble) about its spin axis to less than 10 micro-radians (2 arc seconds) while it operated in a vacuum. Precision optics monitored the dynamic motion of the "smart rock."

  3. Rock critics as 'Mouldy Modernists'

    Directory of Open Access Journals (Sweden)

    Becky Shepherd

    2011-08-01

    Full Text Available Contemporary rock criticism appears to be firmly tied to the past. The specialist music press valorise rock music of the 1960s and 1970s, and new emerging artists are championed for their ‘retro’ sounding music by journalists who compare the sound of these new artists with those included in the established ‘canon’ of rock music. This article examines the narrative tropes of authenticity and nostalgia that frame the retrospective focus of this contemporary rock writing, and most significantly, the maintenance of the rock canon within contemporary popular culture. The article concludes by suggesting that while contemporary rock criticism is predominately characterised by nostalgia, this nostalgia is not simply a passive romanticism of the past. Rather, this nostalgia fuels a process of active recontextualisation within contemporary popular culture.

  4. How to define the tool kit for the corrective maintenance service? : a tool kit definition model under the service performance criterion

    NARCIS (Netherlands)

    Chen, Denise

    2009-01-01

    Currently, the rule of defining tool kits is varied and more engineer's aspects oriented. However, the decision of the tool kit's definition is a trade-off problem between the cost and the service performance. This project is designed to develop a model that can integrate the engineer's preferences

  5. Prediction of Fracture Behavior in Rock and Rock-like Materials Using Discrete Element Models

    Science.gov (United States)

    Katsaga, T.; Young, P.

    2009-05-01

    The study of fracture initiation and propagation in heterogeneous materials such as rock and rock-like materials are of principal interest in the field of rock mechanics and rock engineering. It is crucial to study and investigate failure prediction and safety measures in civil and mining structures. Our work offers a practical approach to predict fracture behaviour using discrete element models. In this approach, the microstructures of materials are presented through the combination of clusters of bonded particles with different inter-cluster particle and bond properties, and intra-cluster bond properties. The geometry of clusters is transferred from information available from thin sections, computed tomography (CT) images and other visual presentation of the modeled material using customized AutoCAD built-in dialog- based Visual Basic Application. Exact microstructures of the tested sample, including fractures, faults, inclusions and void spaces can be duplicated in the discrete element models. Although the microstructural fabrics of rocks and rock-like structures may have different scale, fracture formation and propagation through these materials are alike and will follow similar mechanics. Synthetic material provides an excellent condition for validating the modelling approaches, as fracture behaviours are known with the well-defined composite's properties. Calibration of the macro-properties of matrix material and inclusions (aggregates), were followed with the overall mechanical material responses calibration by adjusting the interfacial properties. The discrete element model predicted similar fracture propagation features and path as that of the real sample material. The path of the fractures and matrix-inclusion interaction was compared using computed tomography images. Initiation and fracture formation in the model and real material were compared using Acoustic Emission data. Analysing the temporal and spatial evolution of AE events, collected during the

  6. Basic and clinical evaluation of CA 130 RIA kit (D-7111) using two newly developed monoclonal antibodies. Comparison with CA 125 kit

    Energy Technology Data Exchange (ETDEWEB)

    Saga, Tsuneo; Endo, Keigo; Nakajima, Tetsuo and others

    1988-10-01

    The CA 130 RIA kit was developed with the use of two monoclonal antibodies, 130 - 22 and 145 - 9. Laboratory performance was satisfactory for precision, reproducibility, recovery, and dilution. Measurement values with CA 130 kit were almost consistent with those with CA 125 kit. Favorable standard curves were attained with smaller concentrations and shorter incubation time of CA 130 kit than those with CA 125 kit. There was less prozone phenomenon. When defining a cut-off serum level of CA 130 as 35 U/ml, false-positive rate was 0 % for healthy men and 4 % for healthy women, suggesting the involvement of menstrual cycle. Positive rate for CA 130 was 65 % for malignant ovarian tumor, 48 % for lung cancer, and 47 % for endometriosis. (Namekawa, K.).

  7. Grafted c-kit+/SSEA1- eye-wall progenitor cells delay retinal degeneration in mice by regulating neural plasticity and forming new graft-to-host synapses.

    Science.gov (United States)

    Chen, Xi; Chen, Zehua; Li, Zhengya; Zhao, Chen; Zeng, Yuxiao; Zou, Ting; Fu, Caiyun; Liu, Xiaoli; Xu, Haiwei; Yin, Zheng Qin

    2016-12-30

    Despite diverse pathogenesis, the common pathological change observed in age-related macular degeneration and in most hereditary retinal degeneration (RD) diseases is photoreceptor loss. Photoreceptor replacement by cell transplantation may be a feasible treatment for RD. The major obstacles to clinical translation of stem cell-based cell therapy in RD remain the difficulty of obtaining sufficient quantities of appropriate and safe donor cells and the poor integration of grafted stem cell-derived photoreceptors into the remaining retinal circuitry. Eye-wall c-kit + /stage-specific embryonic antigen 1 (SSEA1) - cells were isolated via fluorescence-activated cell sorting, and their self-renewal and differentiation potential were detected by immunochemistry and flow cytometry in vitro. After labeling with quantum nanocrystal dots and transplantation into the subretinal space of rd1 RD mice, differentiation and synapse formation by daughter cells of the eye-wall c-kit + /SSEA1 - cells were evaluated by immunochemistry and western blotting. Morphological changes of the inner retina of rd1 mice after cell transplantation were demonstrated by immunochemistry. Retinal function of rd1 mice that received cell grafts was tested via flash electroretinograms and the light/dark transition test. Eye-wall c-kit + /SSEA1 - cells were self-renewing and clonogenic, and they retained their proliferative potential through more than 20 passages. Additionally, eye-wall c-kit + /SSEA1 - cells were capable of differentiating into multiple retinal cell types including photoreceptors, bipolar cells, horizontal cells, amacrine cells, Müller cells, and retinal pigment epithelium cells and of transdifferentiating into smooth muscle cells and endothelial cells in vitro. The levels of synaptophysin and postsynaptic density-95 in the retinas of eye-wall c-kit + /SSEA1 - cell-transplanted rd1 mice were significantly increased at 4 weeks post transplantation. The c-kit + /SSEA1 - cells were

  8. Can you play basketball in space?

    DEFF Research Database (Denmark)

    Jacobsen, Aase Roland; Knudsen, Ole J.

    2004-01-01

    AbstractInspired by NASA’s Activity Kit “Toys in Space” a live program was conducted during World Space Week 2003 at The Steno Museum Planetarium (in collaboration with Orion Planetarium and Tycho Brahe Planetarium).Many well known toys act familiar because of a dominating force downwards caused ...

  9. Late development of homoeothermy in mink (Mustela vison) kits - a strategy for maximum survival rate

    DEFF Research Database (Denmark)

    Tauson, A-H; Chwalibog, André; Tygesen, M P

    2006-01-01

    and after the experiments and evaporative water losses (EWL) were calculated. When exposed to L temperature, single kits responded with a very low HE until 29 days of age, and groups of kits until 14 days of age. It was not until they reached an age of approximately 6 weeks that single kits showed a clear...... thermoregulatory response to the L temperature by increased HE, whereas groups of kits showed increased HE from 29th day onwards. When kept at H temperature, HE was low initially, but all kits showed elevated HE at 8 days of age, and the metabolic rate was similar for single kits and kits huddling in groups....... Evaporative water losses was higher among single than among groups of kits and slightly lower but more variable for animals at L than at H temperature. It was concluded that mink kits develop functional homoeothermy at an age of close to 6 weeks and that the failure of very young kits to thermoregulate...

  10. Rock.XML - Towards a library of rock physics models

    Science.gov (United States)

    Jensen, Erling Hugo; Hauge, Ragnar; Ulvmoen, Marit; Johansen, Tor Arne; Drottning, Åsmund

    2016-08-01

    Rock physics modelling provides tools for correlating physical properties of rocks and their constituents to the geophysical observations we measure on a larger scale. Many different theoretical and empirical models exist, to cover the range of different types of rocks. However, upon reviewing these, we see that they are all built around a few main concepts. Based on this observation, we propose a format for digitally storing the specifications for rock physics models which we have named Rock.XML. It does not only contain data about the various constituents, but also the theories and how they are used to combine these building blocks to make a representative model for a particular rock. The format is based on the Extensible Markup Language XML, making it flexible enough to handle complex models as well as scalable towards extending it with new theories and models. This technology has great advantages as far as documenting and exchanging models in an unambiguous way between people and between software. Rock.XML can become a platform for creating a library of rock physics models; making them more accessible to everyone.

  11. String Theory Rocks!

    CERN Multimedia

    2008-01-01

    String Theory supporters argue that the universe we live in has eleven dimensions, out of which three spacial dimensions and a temporal one, which define the void and the space-time environment we experience daily.

  12. Design of Rock Slope Reinforcement: An Himalayan Case Study

    Science.gov (United States)

    Tiwari, Gaurav; Latha, Gali Madhavi

    2016-06-01

    The stability analysis of the two abutment slopes of a railway bridge proposed at about 359 m above the ground level, crossing a river and connecting two hill faces in the Himalayas, India, is presented. The bridge is located in a zone of high seismic activity. The rock slopes are composed of a heavily jointed rock mass and the spacing, dip and dip direction of joint sets are varying at different locations. Geological mapping was carried out to characterize all discontinuities present along the slopes. Laboratory and field investigations were conducted to assess the geotechnical properties of the intact rock, rock mass and joint infill. Stability analyses of these rock slopes were carried out using numerical programmes. Loads from the foundations resting on the slopes and seismic accelerations estimated from site-specific ground response analysis were considered. The proposed slope profile with several berms between successive foundations was simulated in the numerical model. An equivalent continuum approach with Hoek and Brown failure criterion was initially used in a finite element model to assess the global stability of the slope abutments. In the second stage, finite element analysis of rock slopes with all joint sets with their orientations, spacing and properties explicitly incorporated into the numerical model was taken up using continuum with joints approach. It was observed that the continuum with joints approach was able to capture the local failures in some of the slope sections, which were verified using wedge failure analysis and stereographic projections. Based on the slope deformations and failure patterns observed from the numerical analyses, rock anchors were designed to achieve the target factors of safety against failure while keeping the deformations within the permissible limits. Detailed design of rock anchors and comparison of the stability of slopes with and without reinforcement are presented.

  13. Rocks under pressure

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-05-01

    Physicists have used nuclear magnetic resonance to investigate the destructive effects of the crystallization of salt. Salt-weathering is one of the main causes of rock disintegration in nature, particularly in deserts, polar regions and along coastlines. However, it is also a very widespread cause of damage to man-made constructions. Bridges, for example, are attacked by de-icing salts, and cities such as Bahrain, Abu Dhabi and Adelaide are affected by rising damp from high ground-water levels. Indeed, many examples of cultural heritage, including the Islamic sites of Bokhara and Petra in Jordan and the Sphinx in Egypt, may ultimately be destroyed due to the effects of salt-weathering. Now Lourens Rijniers and colleagues at Eindhoven University in the Netherlands have developed a way to observe the solubility of various salts inside porous materials directly (Phys. Rev. Lett. 94 075503). (U.K.)

  14. Rock the Globe

    CERN Multimedia

    Laëtitia Pedroso

    2010-01-01

    Created in 2005, the Swiss rock band "Wind of Change" is now candidate for the Eurovision Song Contest 2011 with a new song " Night & Light " with the music video filmed at CERN.   With over 20 gigs under their belt and two albums already released, the five members of the band (Alex Büchi, vocals; Arthur Spierer, drums; David Gantner, bass; Romain Mage and Yannick Gaudy, guitar) continue to excite audiences. For their latest composition "Night & Light", the group filmed their music video in the Globe of Science and Innovation. Winning the Eurovision contest would be a springboard in their artistic career for these young musicians. The selection results will be available December 11, 2010.      

  15. Hard rock tunneling using pulsed electron beams

    International Nuclear Information System (INIS)

    Avery, R.T.; Brekke, T.L.; Finnie, I.

    1974-01-01

    Intense submicrosecond bursts of energetic electrons cause significant pulverization and surface spalling of a variety of rock types, the spall debris generally consisting of sand, dust, and small flakes. If carried out at rapid repetition rate this can lead to a promising technique for increasing the speed and reducing the cost of underground excavation of tunnels, mines, and storage spaces. The conceptual design features of a Pulsed Electron Tunnel Excavator capable of tunneling approximately ten times faster than conventional drill/blast methods were studied. (auth)

  16. Prevention and forecasting of rock burst hazards in coal mines

    Energy Technology Data Exchange (ETDEWEB)

    Lin-ming Dou; Cai-ping Lu; Zong-long Mu; Ming-shi Gao [China University of Mining & Technology, Xuzhou (China). State Key Laboratory for Coal Resource and Mine Safety

    2009-09-15

    Rock bursts signify extreme behavior in coal mine strata and severely threaten the safety of the lives of miners, as well as the effectiveness and productivity of miners. In our study, an elastic-plastic-brittle model for the deformation and failure of coal/rock was established through theoretical analyses, laboratory experiments and field testing, simulation and other means, which perfectly predict sudden and delayed rock bursts. Based on electromagnetic emission (EME), acoustic emission (AE) and microseismic (MS) effects in the process from deformation until impact rupture of coal-rock combination samples, a multi-parameter identification of premonitory technology was formed, largely depending on these three forms of emission. Thus a system of classification for forecasting rock bursts in space and time was established. We have presented the intensity weakening theory for rock bursts and a strong-soft-strong (3S) structural model for controlling the impact on rock surrounding roadways, with the objective of laying a theoretical foundation and establishing references for parameters for the weakening control of rock bursts. For the purpose of prevention, key technical parameters of directional hydraulic fracturing are revealed. Based on these results, as well as those from deep-hole controlled blasting in coal seams and rock, integrated control techniques were established and anti-impact hydraulic props, suitable for roadways subject to hazards from rockbursts have also been developed. These technologies have been widely used in most coal mines in China, subject to these hazards and have achieved remarkable economic and social benefits. 28 refs., 9 figs., 1 tab.

  17. ESR dating of the fault rocks

    International Nuclear Information System (INIS)

    Lee, Hee Kwon

    2005-01-01

    We carried out ESR dating of fault rocks collected near the nuclear reactor. The Upcheon fault zone is exposed close to the Ulzin nuclear reactor. The space-time pattern of fault activity on the Upcheon fault deduced from ESR dating of fault gouge can be summarised as follows : this fault zone was reactivated between fault breccia derived from Cretaceous sandstone and tertiary volcanic sedimentary rocks about 2 Ma, 1.5 Ma and 1 Ma ago. After those movements, the Upcheon fault was reactivated between Cretaceous sandstone and fault breccia zone about 800 ka ago. This fault zone was reactivated again between fault breccia derived form Cretaceous sandstone and Tertiary volcanic sedimentary rocks about 650 ka and after 125 ka ago. These data suggest that the long-term(200-500 k.y.) cyclic fault activity of the Upcheon fault zone continued into the Pleistocene. In the Ulzin area, ESR dates from the NW and EW trend faults range from 800 ka to 600 ka NE and EW trend faults were reactivated about between 200 ka and 300 ka ago. On the other hand, ESR date of the NS trend fault is about 400 ka and 50 ka. Results of this research suggest the fault activity near the Ulzin nuclear reactor fault activity continued into the Pleistocene. One ESR date near the Youngkwang nuclear reactor is 200 ka

  18. Current Status on Stress Diagnostic Kit and Detection Technology

    International Nuclear Information System (INIS)

    Park, Sang Hyun; Choi, Mi Hee; Ko, Kyong Cheol

    2008-06-01

    The accurate measurement of a stress level is one of the most important issues in a stress diagnosis and its measurement could be of great value in clinical medicine. Stress has a potent effect on the spirit and physical condition of an individual. There are various methods available for its measurement. Some of the commonly used techniques for the diagnosis of a stress level include analysis of the body fluids, questionnaire assessments, psychophysiological evaluations and by determining heart rate variability (HRV) of subjects. However, the existing diagnostic methods have several defects like, a low sensitivity, inaccuracy and long of operation time. In this report, we present a diagnostic technology to detect a stress level which is the origin of various diseases. This method can be of great help in providing an early diagnosis through a biosensor and might play a vital role in preventing diseases like hypochondria and hypertension. Majority of the human population is exposed to stress in one way or another and hence developing a convenient stress diagnosis kit will be of great use to all. This stress diagnostic kit and detection technology dose not involve simple a mechanical measurement or questionnaires, but is based on developing a detection kit with a high sensitivity, which will mean an easy use for common man. Individuals can undergo regular check ups and can personally diagnose their present situation of health by determining their stress levels, thus enabling them to diagnose the early onset of several stress disorders. This might help them take precautionary measures and thereby lead to a healthy life

  19. Analytical framework and tool kit for SEA follow-up

    International Nuclear Information System (INIS)

    Nilsson, Mans; Wiklund, Hans; Finnveden, Goeran; Jonsson, Daniel K.; Lundberg, Kristina; Tyskeng, Sara; Wallgren, Oskar

    2009-01-01

    Most Strategic Environmental Assessment (SEA) research and applications have so far neglected the ex post stages of the process, also called SEA follow-up. Tool kits and methodological frameworks for engaging effectively with SEA follow-up have been conspicuously missing. In particular, little has so far been learned from the much more mature evaluation literature although many aspects are similar. This paper provides an analytical framework and tool kit for SEA follow-up. It is based on insights and tools developed within programme evaluation and environmental systems analysis. It is also grounded in empirical studies into real planning and programming practices at the regional level, but should have relevance for SEA processes at all levels. The purpose of the framework is to promote a learning-oriented and integrated use of SEA follow-up in strategic decision making. It helps to identify appropriate tools and their use in the process, and to systematise the use of available data and knowledge across the planning organization and process. It distinguishes three stages in follow-up: scoping, analysis and learning, identifies the key functions and demonstrates the informational linkages to the strategic decision-making process. The associated tool kit includes specific analytical and deliberative tools. Many of these are applicable also ex ante, but are then used in a predictive mode rather than on the basis of real data. The analytical element of the framework is organized on the basis of programme theory and 'DPSIR' tools. The paper discusses three issues in the application of the framework: understanding the integration of organizations and knowledge; understanding planners' questions and analytical requirements; and understanding interests, incentives and reluctance to evaluate

  20. Current Status on Stress Diagnostic Kit and Detection Technology

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sang Hyun; Choi, Mi Hee; Ko, Kyong Cheol

    2008-06-15

    The accurate measurement of a stress level is one of the most important issues in a stress diagnosis and its measurement could be of great value in clinical medicine. Stress has a potent effect on the spirit and physical condition of an individual. There are various methods available for its measurement. Some of the commonly used techniques for the diagnosis of a stress level include analysis of the body fluids, questionnaire assessments, psychophysiological evaluations and by determining heart rate variability (HRV) of subjects. However, the existing diagnostic methods have several defects like, a low sensitivity, inaccuracy and long of operation time. In this report, we present a diagnostic technology to detect a stress level which is the origin of various diseases. This method can be of great help in providing an early diagnosis through a biosensor and might play a vital role in preventing diseases like hypochondria and hypertension. Majority of the human population is exposed to stress in one way or another and hence developing a convenient stress diagnosis kit will be of great use to all. This stress diagnostic kit and detection technology dose not involve simple a mechanical measurement or questionnaires, but is based on developing a detection kit with a high sensitivity, which will mean an easy use for common man. Individuals can undergo regular check ups and can personally diagnose their present situation of health by determining their stress levels, thus enabling them to diagnose the early onset of several stress disorders. This might help them take precautionary measures and thereby lead to a healthy life.

  1. Rock Art in Kurdistan Iran

    Directory of Open Access Journals (Sweden)

    Jamal Lahafian

    2013-12-01

    Full Text Available Kurdistan, with great potential and prehistoric resources, has numerous petroglyphs in different areas of the province. During the last 14 years of extensive field study, more than 30 sites of rock art have been identified and introduced by the author. In this article, we summarize these rock art areas in Iranian Kurdistan.

  2. Rockin' around the Rock Cycle

    Science.gov (United States)

    Frack, Susan; Blanchard, Scott Alan

    2005-01-01

    In this activity students will simulate how sedimentary rocks can be changed into metamorphic rocks by intense pressure. The materials needed are two small pieces of white bread, one piece of wheat bread, and one piece of a dark bread (such as pumpernickel or dark rye) per student, two pieces of waxed paper, scissors, a ruler, and heavy books.…

  3. 'Mister Badger' Pushing Mars Rock

    Science.gov (United States)

    1976-01-01

    Viking's soil sampler collector arm successfully pushed a rock on the surface of Mars during the afternoon of Friday, October 8. The irregular-shaped rock was pushed several inches by the Lander's collector arm, which displaced the rock to the left of its original position, leaving it cocked slightly upward. Photographs and other information verified the successful rock push. Photo at left shows the soil sampler's collector head pushing against the rock, named 'Mister Badger' by flight controllers. Photo at right shows the displaced rock and the depression whence it came. Part of the soil displacement was caused by the collector s backhoe. A soil sample will be taken from the site Monday night, October 11. It will then be delivered to Viking s organic chemistry instrument for a series of analyses during the next few weeks. The sample is being sought from beneath a rock because scientists believe that, if there are life forms on Mars, they may seek rocks as shelter from the Sun s intense ultraviolet radiation.

  4. Influence of nest box environment on kit survival

    DEFF Research Database (Denmark)

    Lund, V.H.; Malmkvist, Jens

    2012-01-01

    females divided into 4 groups, non-pregnant females (NON), pregnant females with access to one resource of nest building material (RES-1), pregnant females with access to three resources (RES-3), and pregnant females with access to one resource but which were moved into a climate-controlled facility...... died from day 1-7, and only ~5% in RES-3. The risk of dying was approx. 4 times higher for a kit live-born into the one resource environment. RES-3 females were building better nests and stayed in the nest box longer around parturition than RES-1, which could explain the higher mortality in this group...

  5. A safety-critical java technology compatibility kit

    DEFF Research Database (Denmark)

    Søndergaard, Hans; Korsholm, Stephan E.; Ravn, Anders Peter

    2014-01-01

    In order to claim conformance with a given Java Specification Request (JSR), a Java implementation has to pass all tests in an associated Technology Compatibility Kit (TCK). This paper presents development of test cases and tools for the draft Safety-Critical Java (SCJ) specification. In previous...... work we have shown how the Java Modeling Language (JML) is applied to specify conformance constraints for SCJ, and how JML-related tools may assist in generating and executing tests. Here we extend this work with a layout for concrete test cases including checking of results in a simplified version...

  6. Stannous ion determination in99mTc - radiopharmaceutical kits

    International Nuclear Information System (INIS)

    Almeida, M.A.T.M. de; Silva, C.P.G. da.

    1989-10-01

    Two simple and selective methods for determination of stannous ion in radiopharmaceutical kits are proposed. One of this permits the estimation of stannic ion. The first method used is a potentiometric tiration of Sn +2 in HCl medium using KIO 3 solution under nitrogen gas and a redox platinum electrode. The second method consist of a compleximetric tiration of tin (Sn +2 and Sn +4 ) using EDTA standart solution at pH 5.5-5.6 without use of nitrogen gas. The employed procedures indicates that both the methods can be used for routine quantitative determination of tin in most labeled radiopharmaceuticals. (author) [pt

  7. Apollo rocks, fines and soil cores

    Science.gov (United States)

    Allton, J.; Bevill, T.

    Apollo rocks and soils not only established basic lunar properties and ground truth for global remote sensing, they also provided important lessons for planetary protection (Adv. Space Res ., 1998, v. 22, no. 3 pp. 373-382). The six Apollo missions returned 2196 samples weighing 381.7 kg, comprised of rocks, fines, soil cores and 2 gas samples. By examining which samples were allocated for scientific investigations, information was obtained on usefulness of sampling strategy, sampling devices and containers, sample types and diversity, and on size of sample needed by various disciplines. Diversity was increased by using rakes to gather small rocks on the Moon and by removing fragments >1 mm from soils by sieving in the laboratory. Breccias and soil cores are diverse internally. Per unit weight these samples were more often allocated for research. Apollo investigators became adept at wringing information from very small sample sizes. By pushing the analytical limits, the main concern was adequate size for representative sampling. Typical allocations for trace element analyses were 750 mg for rocks, 300 mg for fines and 70 mg for core subsamples. Age-dating and isotope systematics allocations were typically 1 g for rocks and fines, but only 10% of that amount for core depth subsamples. Historically, allocations for organics and microbiology were 4 g (10% for cores). Modern allocations for biomarker detection are 100mg. Other disciplines supported have been cosmogenic nuclides, rock and soil petrology, sedimentary volatiles, reflectance, magnetics, and biohazard studies . Highly applicable to future sample return missions was the Apollo experience with organic contamination, estimated to be from 1 to 5 ng/g sample for Apollo 11 (Simonheit &Flory, 1970; Apollo 11, 12 &13 Organic contamination Monitoring History, U.C. Berkeley; Burlingame et al., 1970, Apollo 11 LSC , pp. 1779-1792). Eleven sources of contaminants, of which 7 are applicable to robotic missions, were

  8. Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation

    DEFF Research Database (Denmark)

    Jensen, Bettina M; Beaven, Michael A; Iwaki, Shoko

    2008-01-01

    Although primarily required for the growth, differentiation, and survival of mast cells, Kit ligand (stem cell factor) is also required for optimal antigen-mediated mast cell activation. Therefore, concurrent inhibition of Kit- and FcepsilonRI-mediated signaling would be an attractive approach...... characterized Kit inhibitor imatinib mesylate (imatinib). In contrast to imatinib, however, hypothemycin also effectively inhibited FcepsilonRI-mediated degranulation and cytokine production in addition to the potentiation of these responses via Kit. The effect of hypothemycin on Kit-mediated responses could...... be explained by its inhibition of Kit kinase activity, whereas the inhibitory effects on FcepsilonRI-dependent signaling were at the level of Btk activation. Because hypothemycin also significantly reduced the mouse passive cutaneous anaphylaxis response in vivo, these data provide proof of principle...

  9. Rock suitability classification RSC 2012

    Energy Technology Data Exchange (ETDEWEB)

    McEwen, T. (ed.) [McEwen Consulting, Leicester (United Kingdom); Kapyaho, A. [Geological Survey of Finland, Espoo (Finland); Hella, P. [Saanio and Riekkola, Helsinki (Finland); Aro, S.; Kosunen, P.; Mattila, J.; Pere, T.

    2012-12-15

    This report presents Posiva's Rock Suitability Classification (RSC) system, developed for locating suitable rock volumes for repository design and construction. The RSC system comprises both the revised rock suitability criteria and the procedure for the suitability classification during the construction of the repository. The aim of the classification is to avoid such features of the host rock that may be detrimental to the favourable conditions within the repository, either initially or in the long term. This report also discusses the implications of applying the RSC system for the fulfilment of the regulatory requirements concerning the host rock as a natural barrier and the site's overall suitability for hosting a final repository of spent nuclear fuel.

  10. Rock suitability classification RSC 2012

    International Nuclear Information System (INIS)

    McEwen, T.; Kapyaho, A.; Hella, P.; Aro, S.; Kosunen, P.; Mattila, J.; Pere, T.

    2012-12-01

    This report presents Posiva's Rock Suitability Classification (RSC) system, developed for locating suitable rock volumes for repository design and construction. The RSC system comprises both the revised rock suitability criteria and the procedure for the suitability classification during the construction of the repository. The aim of the classification is to avoid such features of the host rock that may be detrimental to the favourable conditions within the repository, either initially or in the long term. This report also discusses the implications of applying the RSC system for the fulfilment of the regulatory requirements concerning the host rock as a natural barrier and the site's overall suitability for hosting a final repository of spent nuclear fuel

  11. Rock strength under explosive loading

    International Nuclear Information System (INIS)

    Rimer, N.; Proffer, W.

    1993-01-01

    This presentation emphasizes the importance of a detailed description of the nonlinear deviatoric (strength) response of the surrounding rock in the numerical simulation of underground nuclear explosion phenomenology to the late times needed for test ban monitoring applications. We will show how numerical simulations which match ground motion measurements in volcanic tuffs and in granite use the strength values obtained from laboratory measurements on small core samples of these rocks but also require much lower strength values after the ground motion has interacted with the rock. The underlying physical mechanisms for the implied strength reduction are not yet well understood, and in fact may depend on the particular rock type. However, constitutive models for shock damage and/or effective stress have been used successfully at S-Cubed in both the Geophysics Program (primarily for DARPA) and the Containment Support Program (for DNA) to simulate late time ground motions measured at NTS in many different rock types

  12. ROCK inhibitors in ocular disease

    Directory of Open Access Journals (Sweden)

    Eva Halasz

    2016-12-01

    Full Text Available Rho kinases (ROCKs have a crucial role in actin-cytoskeletal reorganization and thus are involved in broad aspects of cell motility, from smooth muscle contraction to neurite outgrowth. The first marketed ROCK inhibitor, called fasudil, has been used safely for treatment of cerebral vasospasm since 1995 in Japan. During the succeeding decades ROCK inhibitors have been applied in many pathological conditions from central nervous system disorders to cardiovascular disease as potential therapeutic agents or experimental tools to help understand the underlying (pathomechanisms. In 2014, a fasudil derivate named ripasudil was accepted for clinical use in glaucoma and ocular hypertension. Since ROCK kinases are widely expressed in ocular tissues, they have been implicated in the pathology of many ocular conditions such as corneal dysfunction, glaucoma, cataract, diabetic retinopathy, age-related macular degeneration, and retinal detachment. This paper aims to provide an overview of the most recent status/application of ROCK inhibitors in the field of eye disease.

  13. Installation of depository for radioactive material in rocks

    International Nuclear Information System (INIS)

    Bergman, S.G.A.; Sagefors, K.I.; Aakesson, B.Aa.

    1985-01-01

    The rock outside the depository has a hollow space which is filled by elastoplastic material possible to deform. The solid body of the depository has a central vertical shaft and concentric vertical outer shafts. Between the shafts there are vertically oriented layers with tunnels for storage of waste. The tunnels slope down from the central shaft. (G.B.)

  14. Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders

    DEFF Research Database (Denmark)

    Jensen, Bettina Margrethe; Akin, C; Gilfillan, A M

    2008-01-01

    within these tissues, mast cell activation by antigen may also be amplified by SCF. Thus, KIT inhibitors may have potential application in multiple conditions linked to mast cells including systemic mastocytosis, anaphylaxis, and asthma. In this review, we discuss the role of KIT in the context of mast...... cells in these disease states and how recent advances in the development of inhibitors of KIT activity and function may offer novel therapies for the treatment of these disorders....

  15. Application of an FSH-RIA-kit in the clinical practice

    International Nuclear Information System (INIS)

    Delzer, W.; Herzmann, H.

    1982-01-01

    First clinical experiences with an FSH-RIA-kit developed in the Central Institute for Isotope- and Radiation Research are reported. Simultaneously carried out LH and FSH determination during the menstruation cycle with special regard of the middle of the cycle revealed increased hormone values in the preovulatory phase. The problem of evaluation of hormone values achieved by different kits (standards), was investigated simultaneous determination of the sera using the own and an imported kit. (author)

  16. The clinical testing of a Hungarian-made triiodothyronine radioimmunoassay kit

    International Nuclear Information System (INIS)

    Gyertyanfy, G.; Foeldes, J.

    1981-01-01

    The parameters of the calibration curve of the new Hungarian RK-11 kit for the determination of the total T3 content of the serum and the reliability of the results were studied. The data of the measurements made on a number of patients by RK-11, Biodata and Byk-Mallinckrodt kits were compared. The new kit seems to be applicable to the determination of the total T3 content in the serum. (author)

  17. C-kit-targeted imaging of gastrointestinal stromal tumor using radiolabeled anti-c-kit monoclonal antibody in a mouse tumor model

    International Nuclear Information System (INIS)

    Sogawa, Chizuru; Tsuji, Atsushi B.; Sudo, Hitomi; Sugyo, Aya; Yoshida, Chisato; Odaka, Kenichi; Uehara, Tomoya; Arano, Yasushi; Koizumi, Mitsuru; Saga, Tsuneo

    2010-01-01

    Introduction: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor arising from the gastrointestinal tract and highly expresses mutated c-kit. We aimed to develop a specific and sensitive method for detecting GISTs using radiolabeled anti-c-kit monoclonal antibody. Methods: A mutated c-kit-expressing cell clone was established by transfecting an expressing vector of mutated c-kit gene into HEK293 human embryonic kidney cells. The tumors were developed by inoculating c-kit-expressing cells into nude mice. 125 I- and 111 In-labeled anti-c-kit antibodies (12A8 and 41A11) were evaluated in vitro by cell binding, competitive inhibition and cellular internalization assays, and in vivo by biodistribution and imaging studies in tumor-bearing mice. Results: Both 125 I- and 111 In-labeled antibodies showed specific binding with c-kit-expressing cells with high affinity (dissociation constants = 2.2-7.1x10 9 M -1 ). Internalization assay showed that 125 I-labeled antibodies were rapidly internalized and dehalogenated, with the release of 125 I from the cells, resulting in reduction of cell-associated radioactivity with time. In contrast, 111 In-labeled antibody was internalized but did not result in the reduced radioactivity associated with tumor cells. Reflecting this phenomenon, the in vivo tumor uptake of 125 I-labeled antibody was low on Day 1, further decreasing with time, while tumor uptake of 111 In-labeled antibody was high on Day 1, further increasing with time. The xenografted tumor was clearly visualized by scintigraphy after injection of 111 In-labeled antibody. Conclusion: The anti-c-kit monoclonal antibody labeled with a metal radionuclide would be promising for c-kit-targeted imaging of GISTs.

  18. Performances of Four Helicobacter pylori Serological Detection Kits Using Stool Antigen Test as Gold Standard.

    Directory of Open Access Journals (Sweden)

    Susheela D Biranjia-Hurdoyal

    Full Text Available The aim was to determine the performances of four Helicobacter pylori serological detection kits in different target groups, using Amplified IDEIA™ Hp StAR™ as gold standard. Kits studied were Rapid Immunochromatoghraphic Hexagon, Helicoblot 2.1, an EIA IgG kit and EIA IgA kit.Stool and blood samples were collected from 162 apparently healthy participants (control and 60 Type 2 diabetes mellitus (T2DM patients.The performances of the four serological detection kits were found to be affected by gender, age, health status and ethnicity of the participants. In the control group, the Helicoblot 2.1 kit had the best performance (AUC = 0.85; p<0.05, accuracy = 86.4%, followed by EIA IgG (AUC = 0.75; p<0.05, accuracy = 75.2%. The Rapid Hexagon and EIA IgA kits had relatively poor performances. In the T2DM subgroup, the kits H2.1 and EIA IgG had best performances, with accuracies of 96.5% and 93.1% respectively. The performance of EIA IgG improved with adjustment of its cut-off value.The performances of the detection kits were affected by various factors which should be taken into consideration.

  19. Single vial kit formulation for preparation of PET radiopharmaceutical. 68Ga-DOTA-TOC

    International Nuclear Information System (INIS)

    Archana Mukherjee; Usha Pandey; Rubel Chakravarty; Ashutosh Dash; Haladhar Dev Sarma

    2014-01-01

    This paper describes the development of a lyophilized cold kit of DOTA-[Tyr 3 ]-Octreotide (DOTA-TOC) for instant compounding of 68 Ga-DOTA-TOC, suitable for diagnosis of neuroendocrine tumors. The work involved formulation of DOTA-TOC kits, optimization of radiolabeling, quality control of 68 Ga-DOTA-TOC and animal biodistribution studies. The prepared kits enable a reliable method for preparation of 68 Ga-DOTA-TOC of high radiochemical purity and excellent stability. Availability of such kits along with 68 Ge/ 68 Ga generators is expected to stimulate the widespread use of 68 Ga-DOTA-TOC in nuclear medicine practice in developing countries. (author)

  20. Solid state nuclear track detectors kit for the use in teaching

    International Nuclear Information System (INIS)

    Khouri, M.T.F.C.; Koskinas, M.F.

    1988-11-01

    The kit intends to improve the possibilities in performing experiments of Nuclear Physics in Modern Physics laboratories of Physics Course introducing the solid state nuclear track detectors. In these materials the passage of heavily ionizing nuclear particles creates paths (tracks) that may be revealed and made visible in an optical microscope. By the help of the kit several experiments and/or demonstrations may be performed. The kit contains solid state nuclear track detectors unirradiated and irradiated, irradiated etched and unetched sheets: an alpha source of 241 Am and an instrution text with photomicrographs. To use the kit the laboratory must have an ordinary optical microscope. (author) [pt

  1. Recommendations for adaptation and validation of commercial kits for biomarker quantification in drug development.

    Science.gov (United States)

    Khan, Masood U; Bowsher, Ronald R; Cameron, Mark; Devanarayan, Viswanath; Keller, Steve; King, Lindsay; Lee, Jean; Morimoto, Alyssa; Rhyne, Paul; Stephen, Laurie; Wu, Yuling; Wyant, Timothy; Lachno, D Richard

    2015-01-01

    Increasingly, commercial immunoassay kits are used to support drug discovery and development. Longitudinally consistent kit performance is crucial, but the degree to which kits and reagents are characterized by manufacturers is not standardized, nor are the approaches by users to adapt them and evaluate their performance through validation prior to use. These factors can negatively impact data quality. This paper offers a systematic approach to assessment, method adaptation and validation of commercial immunoassay kits for quantification of biomarkers in drug development, expanding upon previous publications and guidance. These recommendations aim to standardize and harmonize user practices, contributing to reliable biomarker data from commercial immunoassays, thus, enabling properly informed decisions during drug development.

  2. Development of an up-to-date NBC self-aid kit for emergency cases

    International Nuclear Information System (INIS)

    Mueller, Michael; Schmiechen, Katharina

    2009-01-01

    In accordance with alterations of the political and economical settings of Central Europe in the last decades, the characteristics of NBC hazards have changed. Since war appears unlikely, possible new scenarios involve pandemics, chemical transport accidents or distribution of CB warfare agents and radioactive materials by terroristic acts. Meeting this situation requires new protection and self aid equipment for the German civilian disaster relief forces. The German government has reacted to these risks by designing personal protection equipment for the civilian voluntary and professional disaster relief forces. The new NBC self aid kit will be part of this effort. The scientific approach of the project consisted of an updated risk analysis, a questionnaire for the professionals and volunteers involved in disaster management, a thorough evaluation of commercially available kits and single components, final design of the new kit including user instructions, and validation of a prototype kit in a disaster relief exercise. Results of the questionnaire stressed the need for a NBC self aid kit fulfilling the demands of easy handling, use of commercially available components, stability of materials, consumption adapted supply and portable size and weight of the complete kit. The evaluation of international NBC equipment could not identify any current NBC self aid kit which satisfies all needs of the German civilian disaster relief forces. The authors therefore compiled a new kit consisting of commercially available components. The newly developed kit was evaluated in a disaster relief exercise.

  3. Data on quantification of signaling pathways activated by KIT and PDGFRA mutants

    Directory of Open Access Journals (Sweden)

    Christelle Bahlawane

    2016-12-01

    Full Text Available The present data are related to the article entitled “Insights into ligand stimulation effects on gastro-intestinal stromal tumors signaling” (C. Bahlawane, M. Schmitz, E. Letellier, K. Arumugam, N. Nicot, P.V. Nazarov, S. Haan, 2016 [1]. Constitutive and ligand-derived signaling pathways mediated by KIT and PDGFRA mutated proteins found in gastrointestinal stromal tumors (GIST were compared. Expression of mutant proteins was induced by doxycycline in an isogenic background (Hek293 cells. Kit was identified by FACS at the cell surface and found to be quickly degraded or internalized upon SCF stimulation for both Kit Wild type and Kit mutant counterparts. Investigation of the main activated pathways in GIST unraveled a new feature specific for oncogenic KIT mutants, namely their ability to be further activated by Kit ligand, the stem cell factor (scf. We were also able to identify the MAPK pathway as the most prominent target for a common inhibition of PDGFRA and KIT oncogenic signaling. Western blotting and micro-array analysis were applied to analyze the capacities of the mutant to induce an effective STATs response. Among all Kit mutants, only Kit Ex11 deletion mutant was able to elicit an effective STATs response whereas all PDGFRA were able to do so.

  4. Determination of tin (II) in radiopharmaceutical kits by polarographic method

    International Nuclear Information System (INIS)

    Aungurarat, A.; Thuntawewadthananon, T.

    1996-01-01

    Radiopharmaceutical kit is a diagnostic compound which contains Stannous (II) as a reducing agent. The quantity of Stannous (II) is depended on the type of kits. So the quantity of Stannous (II) is determined by polarographic method with Differential Pulse Voltammetry (D P Mode) in which a saturated calomel electrode is used as anode and a dropping mercury electrode is used as cathode. Both of electrodes are immerged in the premixed solution of supporting electrolyte and analytical Stannous (II). The Stannous (II) is determined by direct method Stannous (II) is analyzed in the form of Stannous; Sn 2 + itself, and indirect method Stannous (II) is analyzed in the form of S tannic; Sn 4+ (Sn 2+ , + N H 4 + ----> Sn 4+ ). Both methods are done at polarographic half wave potential -470 and -520 mV respectively. The Limit of Detection (LOD) of the direct method is 1.9445 micro g and indirect method is 1.3018 micro g. The result received from indirect method is much more accurate than the direct method (Sn 2+ ). The accuracy of the direct method is about 97.5-102.5% recovery

  5. Behavioral study of cnc-retrofitting kits for lathe machine

    International Nuclear Information System (INIS)

    Ahmad, I.

    1999-01-01

    The aim of this project is to develop a Computerized Numerical Controlled (CNC) retrofitting kit for a lathe machine, study its behavior and compare its performance with the retrofitting kit already designed and fabricated at (Pakistan Institute of Engineering and Applied Sciences (PIEAS). Design calculations were performed assuming 100 mm work piece diameter and 800 mm length of stock using tool materials HSS, uncoated carbide, coated carbide, ceramic and cermet tools for different materials. Also cutting, thrust and radial forces on a single point cutting tool were determined. Stepper motors of torque 972 oz-in were selected to drive the carriage and cross-slide in Z and X-directions respectively. Power screws were replaced with ball screws of 0.63 inch dia. (x-direction) and 1.26 in. dia. (Z-direction) which were locally manufactured in the workshop. Deep groove and Angular contact ball bearings were used to support the ball screw shafts against axial and radial loads. Flexible and plain couplings were developed to couple encoders and motors to the ball screw shafts respectively. Panel mount optical rotary encoders are being used for feedback control. Mechanical assembly is complete but due to unavailability of wiring diagram for motors, control electronics could not be accomplished. Therefore, machine could not be evaluated in terms of accuracy, repeatability and resolution using computer software. (author)

  6. Fundamental and clinical evaluation of osteocalcin RIA kit

    Energy Technology Data Exchange (ETDEWEB)

    Kousaka, Tadako; Yamamoto, Itsuo; Kitamura, Nobuyasu; Aoki, Jun; Uneno, Susumu; Sone, Teruki; Kasai, Ryuuichi; Torizuka, Kanji

    1987-06-01

    The laboratory performance of a double antibody radioimmunoassay (RIA) kit for measuring osteocalcin (OC) was tested for incubation, the effect of anticoagulants, serum storage, dilution, recovery, and reproducibility. Serum OC concentrations increased rapidly with the addition of 5 mM or more ethylenediamine tetraacetic acid, although they were not affected by the addition of heparin. Serum OC measurements, obtained at 2 or 3 weeks after sampling, tended to be lower. The other items, except for dilution, were reliable. Using the OC RIA kit, serum OC concentrations were measured in 161 patients with various diseases and 408 volunteers. Normal upper limit for OC was defined as 11.48 ng/ml. Serum OC concentrations were extremely high up to the age of puberty, and thereafter decreased rapidly with the constant values after the age of 20. Women had increased OC values after the latter half of their fourties. Primary hyperparathyroidism, bone metastases of malignancy, and malignant hypercalcemia were occasionally associated with increased OC values, in contrast to hypoparathyroidism showing decreased OC values. Extremely high values of OC were seen in many of the dialysis patients. (Namekawa, K.).

  7. Preparation and quality control of MAA human serum albumin kit

    International Nuclear Information System (INIS)

    Yassin, T.; Dadokh, M.; Almalki, R.

    2005-05-01

    MAA Macro aggregate Kit for pulmonary perfusion after labeling with 99m Tc was prepared according to an optimum conditions, where each vial contains 0.8 mg of HSA and 0.17 mg of stannous chloride dehydrate (SnCl 2 2H 2 O),The prepared kit showed high quality satisfying the requirements of international pharmacopoeias from the points of physical, chemical, radiochemical and biological purities, and its validity for human injection. And the labeling yield exceeded 99 % with average value of about 99.74 ± 0.27 % for 2mCi/2ml radioactivity, The bio distribution study in rats showed that an average of 93.87 ± 3.97% of injected dose was located in the lungs after 10 minutes where only about 0.99 ± 0.41 % of it was located in the liver and about 0.41 ± 0.14% in the kidneys and blood clearance 1.235 ± 0.78 %. This study also showed that each vial content can be labeled with maximum activity of 99m Tc of about 50 mCi. (Authors)

  8. Low Cost DIY Lenses kit For High School Teaching

    Science.gov (United States)

    Thepnurat, Meechai; Saphet, Parinya; Tong-on, Anusorn

    2017-09-01

    A set of lenses was fabricated from a low cost materials in a DIY (Do it yourself) process. The purpose was to demonstrate to teachers and students in high schools how to construct lenses by themselves with the local available materials. The lenses could be applied in teaching Physics, about the nature of a lens such as focal length and light rays passing through lenses in either direction, employing a set of simple laser pointers. This instrumental kit was made from a transparent 2 mm thick of acrylic Perspex. It was cut into rectangular pieces with dimensions of 2x15 cm2 and bent into curved shape by a hot air blower on a cylindrical wooden rod with curvature radii of about 3-4.5 cm. Then a pair of these Perspex were formed into a hollow thick lenses with a base supporting platform, so that any appropriate liquids could be filled in. The focal length of the lens was measured from laser beam drawing on a paper. The refractive index, n (n) of a filling liquid could be calculated from the measured focal length (f). The kit was low cost and DIY but was greatly applicable for optics teaching in high school laboratory.

  9. Biogenic Cracks in Porous Rock

    Science.gov (United States)

    Hemmerle, A.; Hartung, J.; Hallatschek, O.; Goehring, L.; Herminghaus, S.

    2014-12-01

    Microorganisms growing on and inside porous rock may fracture it by various processes. Some of the mechanisms of biofouling and bioweathering are today identified and partially understood but most emphasis is on chemical weathering, while mechanical contributions have been neglected. However, as demonstrated by the perseverance of a seed germinating and cracking up a concrete block, the turgor pressure of living organisms can be very significant. Here, we present results of a systematic study of the effects of the mechanical forces of growing microbial populations on the weathering of porous media. We designed a model porous medium made of glass beads held together by polydimethylsiloxane (PDMS), a curable polymer. The rheological properties of the porous medium, whose shape and size are tunable, can be controlled by the ratio of crosslinker to base used in the PDMS (see Fig. 1). Glass and PDMS being inert to most chemicals, we are able to focus on the mechanical processes of biodeterioration, excluding any chemical weathering. Inspired by recent measurements of the high pressure (~0.5 Mpa) exerted by a growing population of yeasts trapped in a microfluidic device, we show that yeast cells can be cultured homogeneously within porous medium until saturation of the porous space. We investigate then the effects of such an inner pressure on the mechanical properties of the sample. Using the same model system, we study also the complex interplay between biofilms and porous media. We focus in particular on the effects of pore size on the penetration of the biofilm within the porous sample, and on the resulting deformations of the matrix, opening new perspectives into the understanding of life in complex geometry. Figure 1. Left : cell culture growing in a model porous medium. The white spheres represent the grains, bonds are displayed in grey, and microbes in green. Right: microscopy picture of glass beads linked by PDMS bridges, scale bar: 100 μm.

  10. They will rock you!

    CERN Multimedia

    Anaïs Schaeffer

    2013-01-01

    On 30 September, CERN will be the venue for one of the most prestigious events of the year: the concert for the Bosons&More event, the Organization’s celebration of the remarkable performance of the LHC and all its technical systems, as well as the recent fundamental discoveries. Topping the bill will be the Orchestre de la Suisse Romande, the CERN Choir, the Zürcher Sing-Akademie and the Alan Parsons Live Project rock group, who have joined forces to create an unforgettable evening’s entertainment.   The Orchestre de la Suisse Romande, directed by Maestro Neeme Järvi, artistic and musical director of the OSR. (Image: Grégory Maillot). >>> From the Orchestre de la Suisse Romande… Henk Swinnen, General Manager of the Orchestre de la Suisse Romande (OSR), answers some questions for the CERN Bulletin, just a few days before the event. How did this project come about? When CERN invited us to take part in the B...

  11. Rock salt constitutive modeling

    International Nuclear Information System (INIS)

    Nickell, R.E.

    1980-01-01

    The Serata model is the best operational model available today because it incorporates: (1) a yield function to demarcate between viscoelastic and viscoplastic behavior of rock salt; (2) a pressure and temperature dependence for yield stresses; and (3) a standard linear solid, which can be readily extended into the non-linear regime, to represent creep behavior. Its only deficiencies appear to be the lack of secondary creep behavior (a free dashpot) and some unsettling arbitrariness about the Poisson's ratio (ν → 0.5) argument for viscoplasticity. The Sandia/WIPP model will have good primary and secondary creep capability, but lacks the viscoplastic behavior. In some cases, estimated inelastic strains may be underpredicted. If a creep acceleration mechanism associated with brine inclusions is observed, this model may require extensive revision. Most of the other models available (SAI, RE-SPEC, etc.) are only useful for short-term calculations, because they employ temporal power law (t/sup n/) primary creep representations. These models are unsatisfactory because they cannot represent dual mechanisms with differing characteristic times. An approach based upon combined creep and plasticity is recommended in order to remove the remaining deficiency in the Serata model. DOE/Sandia/WIPP should be encouraged to move aggressively in this regard

  12. Research into basic rocks types

    International Nuclear Information System (INIS)

    1993-06-01

    Teollisuuden Voima Oy (TVO) has carried out research into basic rock types in Finland. The research programme has been implemented in parallel with the preliminary site investigations for radioactive waste disposal in 1991-1993. The program contained two main objectives: firstly, to study the properties of the basic rock types and compare those with the other rock types under the investigation; secondly, to carry out an inventory of rock formations consisting of basic rock types and suitable in question for final disposal. A study of environmental factors important to know regarding the final disposal was made of formations identified. In total 159 formations exceeding the size of 4 km 2 were identified in the inventory. Of these formations 97 were intrusive igneous rock types and 62 originally extrusive volcanic rock types. Deposits consisting of ore minerals, industrial minerals or building stones related to these formations were studied. Environmental factors like natural resources, protected areas or potential for restrictions in land use were also studied

  13. Retractable Robotic Anchor for Hard Rock and Granular Soils, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — ProtoInnovations proposes to research, develop, and validate an innovative retractable robotic anchoring mechanism that works both in hard rock and granular soils...

  14. Rock glacier velocities, Selwyn Mountains, Yukon and NWT, Canada, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — An average of 6 markers were surveyed on each of 15 rock glaciers, once each in 1983 and 1995 using a level (1983) and a theodolite (1995). Measurement error was on...

  15. Retractable Robotic Anchor for Hard Rock and Granular Soils, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — ProtoInnovations, LLC, is developing an innovative retractable robotic anchor that works in hard rock and granular soils permitting anchoring and subsequent...

  16. Laboratory investigations into fracture propagation characteristics of rock material

    Science.gov (United States)

    Prasad, B. N. V. Siva; Murthy, V. M. S. R.

    2018-04-01

    After Industrial Revolution, demand of materials for building up structures have increased enormously. Unfortunately, failures of such structures resulted in loss of life and property. Rock is anisotropic and discontinuous in nature with inherent flaws or so-called discontinuities in it. Rock is apparently used for construction in mining, civil, tunnelling, hydropower, geothermal and nuclear sectors [1]. Therefore, the strength of the structure built up considering rockmass as the construction material needs proper technical evaluation during designing stage itself to prevent and predict the scenarios of catastrophic failures due to these inherent fractures [2]. In this study, samples collected from nine different drilling sites have been investigated in laboratory for understanding the fracture propagation characteristics in rock. Rock material properties, ultrasonic velocities through pulse transmission technique and Mode I Fracture Toughness Testing of different variants of Dolomites and Graywackes are determined in laboratory and the resistance of the rock material to catastrophic crack extension or propagation has been determined. Based on the Fracture Toughness values and the rock properties, critical Energy Release Rates have been estimated. However further studies in this direction is to be carried out to understand the fracture propagation characteristics in three-dimensional space.

  17. Resonant Column Tests and Nonlinear Elasticity in Simulated Rocks

    Science.gov (United States)

    Sebastian, Resmi; Sitharam, T. G.

    2018-01-01

    Rocks are generally regarded as linearly elastic even though the manifestations of nonlinearity are prominent. The variations of elastic constants with varying strain levels and stress conditions, disagreement between static and dynamic moduli, etc., are some of the examples of nonlinear elasticity in rocks. The grain-to-grain contact, presence of pores and joints along with other compliant features induce the nonlinear behavior in rocks. The nonlinear elastic behavior of rocks is demonstrated through resonant column tests and numerical simulations in this paper. Resonant column tests on intact and jointed gypsum samples across varying strain levels have been performed in laboratory and using numerical simulations. The paper shows the application of resonant column apparatus to obtain the wave velocities of stiff samples at various strain levels under long wavelength condition, after performing checks and incorporating corrections to the obtained resonant frequencies. The numerical simulation and validation of the resonant column tests using distinct element method are presented. The stiffness reductions of testing samples under torsional and flexural vibrations with increasing strain levels have been analyzed. The nonlinear elastic behavior of rocks is reflected in the results, which is enhanced by the presence of joints. The significance of joint orientation and influence of joint spacing during wave propagation have also been assessed and presented using the numerical simulations. It has been found that rock joints also exhibit nonlinear behavior within the elastic limit.

  18. Modeling the Rock Glacier Cycle

    Science.gov (United States)

    Anderson, R. S.; Anderson, L. S.

    2016-12-01

    Rock glaciers are common in many mountain ranges in which the ELA lies above the peaks. They represent some of the most identifiable components of today's cryosphere in these settings. Their oversteepened snouts pose often-overlooked hazards to travel in alpine terrain. Rock glaciers are supported by avalanches and by rockfall from steep headwalls. The winter's avalanche cone must be sufficiently thick not to melt entirely in the summer. The spatial distribution of rock glaciers reflects this dependence on avalanche sources; they are most common on lee sides of ridges where wind-blown snow augments the avalanche source. In the absence of rockfall, this would support a short, cirque glacier. Depending on the relationship between rockfall and avalanche patterns, "talus-derived" and "glacier-derived" rock glaciers are possible. Talus-derived: If the spatial distribution of rock delivery is similar to the avalanche pattern, the rock-ice mixture will travel an englacial path that is downward through the short accumulation zone before turning upward in the ablation zone. Advected debris is then delivered to the base of a growing surface debris layer that reduces the ice melt rate. The physics is identical to the debris-covered glacier case. Glacier-derived: If on the other hand rockfall from the headwall rolls beyond the avalanche cone, it is added directly to the ablation zone of the glacier. The avalanche accumulation zone then supports a pure ice core to the rock glacier. We have developed numerical models designed to capture the full range of glacier to debris-covered glacier to rock glacier behavior. The hundreds of meter lengths, tens of meters thicknesses, and meter per year speeds of rock glaciers are well described by the models. The model can capture both "talus-derived" and "glacier-derived" rock glaciers. We explore the dependence of glacier behavior on climate histories. As climate warms, a pure ice debris-covered glacier can transform to a much shorter rock

  19. Multiverso: Rock'n'Astronomy

    Science.gov (United States)

    Caballero, J. A.

    2012-05-01

    In the last few years, there have been several projects involving astronomy and classical music. But have a rock band ever appeared at a science conference or an astronomer at a rock concert? We present a project, Multiverso, in which we mix rock and astronomy, together with poetry and video art (Caballero, 2010). The project started in late 2009 and has already reached tens of thousands people in Spain through the release of an album, several concert-talks, television, radio, newspapers and the internet.

  20. Fault rocks and uranium mineralization

    International Nuclear Information System (INIS)

    Tong Hangshou.

    1991-01-01

    The types of fault rocks, microstructural characteristics of fault tectonite and their relationship with uranium mineralization in the uranium-productive granite area are discussed. According to the synthetic analysis on nature of stress, extent of crack and microstructural characteristics of fault rocks, they can be classified into five groups and sixteen subgroups. The author especially emphasizes the control of cataclasite group and fault breccia group over uranium mineralization in the uranium-productive granite area. It is considered that more effective study should be made on the macrostructure and microstructure of fault rocks. It is of an important practical significance in uranium exploration

  1. Test procedures for salt rock

    International Nuclear Information System (INIS)

    Dusseault, M.B.

    1985-01-01

    Potash mining, salt mining, design of solution caverns in salt rocks, disposal of waste in salt repositories, and the use of granular halite backfill in underground salt rock mines are all mining activities which are practised or contemplated for the near future. Whatever the purpose, the need for high quality design parameters is evident. The authors have been testing salt rocks in the laboratory in a number of configurations for some time. Great care has been given to the quality of sample preparation and test methodology. This paper describes the methods, presents the elements of equipment design, and shows some typical results

  2. Platinum, palladium, and rhodium in volcanic and plutonic rocks from the Gravina-Nutzotin belt, Alaska

    Science.gov (United States)

    Page, Norman J; Berg, Henry C.; Haffty, Joseph

    1977-01-01

    The Gravina-Nutzotin belt of Middle (?) Jurassic to middle Cretaceous sedimentary and volcanic rocks in south and southeastern Alaska includes concentrically zoned ultramafic complexes known to contain platinum-group metals. Previous isotopic, petrologic, and geologic studies suggested a close relation in time and space between the volcanic rocks and the ultramafic complexes. Interpretation of 40 analyses for platinum, palladium, and rhodium in volcanic and plutonic rocks of the belt indicates a strong geochemical correlation between the two groups of rocks and is in support of their being cogenetic either from directly connected magma chambers and flows or indirectly by selective concentration processes from similar mantle material.

  3. Fluid and rock interaction in permeable volcanic rock

    International Nuclear Information System (INIS)

    Lindley, J.I.

    1985-01-01

    Four types of interrelated changes -geochemical, mineralogic, isotopic, and physical - occur in Oligocene volcanic units of the Mogollon-Datil volcanic field, New Mexico. These changes resulted from the operation of a geothermal system that, through fluid-rock interaction, affected 5 rhyolite ash-flow tuffs and an intercalated basaltic andesite lava flow causing a potassium metasomatism type of alteration. (1) Previous studies have shown enrichment of rocks in K 2 O as much as 130% of their original values at the expense of Na 2 O and CaO with an accompanying increase in Rb and decreases in MgO and Sr. (2) X-ray diffraction results of this study show that phenocrystic plagioclase and groundmass feldspar have been replaced with pure potassium feldspar and quartz in altered rock. Phenocrystic potassium feldspar, biotite, and quartz are unaffected. Pyroxene in basaltic andesite is replaced by iron oxide. (3) delta 18 O increases for rhyolitic units from values of 8-10 permil, typical of unaltered rock, to 13-15 permil, typical of altered rock. Basaltic andesite, however, shows opposite behavior with a delta 18 of 9 permil in unaltered rock and 6 permit in altered. (4) Alteration results in a density decrease. SEM revealed that replacement of plagioclase by fine-grained quartz and potassium feldspar is not a volume for volume replacement. Secondary porosity is created in the volcanics by the chaotic arrangement of secondary crystals

  4. Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11

    International Nuclear Information System (INIS)

    Gregory-Bryson, Emmalena; Bartlett, Elizabeth; Kiupel, Matti; Hayes, Schantel; Yuzbasiyan-Gurkan, Vilma

    2010-01-01

    Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms in the gastrointestinal tract of humans and dogs. Little is known about the pathogenesis of these tumors. This study evaluated the role of c-KIT in canine GISTs; specifically, we investigated activating mutations in exons 8, 9, 11, 13, and 17 of c-KIT and exons 12, 14, and 18 of platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), all of which have been implicated in human GISTs. Seventeen canine GISTs all confirmed to be positive for KIT immunostaining were studied. Exons 8, 9, 11, 13 and 17 of c-KIT and exons 12, 14, and 18 of PDGFRA, were amplified from DNA isolated from formalin-fixed paraffin-embedded samples. Of these seventeen cases, six amplicons of exon 11 of c-KIT showed aberrant bands on gel electrophoresis. Sequencing of these amplicons revealed heterozygous in-frame deletions in six cases. The mutations include two different but overlapping six base pair deletions. Exons 8, 9, 13, and 17 of c-KIT and exons 12, 14, and 18 of PDGFRA had no abnormalities detected by electrophoresis and sequencing did not reveal any mutations, other than synonymous single nucleotide polymorphisms (SNPs) found in exon 11 of c-KIT and exons 12 and 14 of PDGFRA. The deletion mutations detected in canine GISTs are similar to those previously found in the juxtamembrane domain of c-KIT in canine cutaneous mast cell tumors in our laboratory as well as to those reported in human GISTs. Interestingly, none of the other c-KIT or PDGFRA exons showed any abnormalities in our cases. This finding underlines the critical importance of c-KIT in the pathophysiology of canine GISTs. The expression of KIT and the identification of these activating mutations in c-KIT implicate KIT in the pathogenesis of these tumors. Our results indicate that mutations in c-KIT may be of prognostic significance and that targeting KIT may be a rational approach to treatment of these malignant tumors. This study further

  5. Rock Moved by Mars Lander Arm, Stereo View

    Science.gov (United States)

    2008-01-01

    The robotic arm on NASA's Phoenix Mars Lander slid a rock out of the way during the mission's 117th Martian day (Sept. 22, 2008) to gain access to soil that had been underneath the rock.The lander's Surface Stereo Imager took the two images for this stereo view later the same day, showing the rock, called 'Headless,' after the arm pushed it about 40 centimeters (16 inches) from its previous location. 'The rock ended up exactly where we intended it to,' said Matt Robinson of NASA's Jet Propulsion Laboratory, robotic arm flight software lead for the Phoenix team. The arm had enlarged the trench near Headless two days earlier in preparation for sliding the rock into the trench. The trench was dug to about 3 centimeters (1.2 inches) deep. The ground surface between the rock's prior position and the lip of the trench had a slope of about 3 degrees downward toward the trench. Headless is about the size and shape of a VHS videotape. The Phoenix science team sought to move the rock in order to study the soil and the depth to subsurface ice underneath where the rock had been. This left-eye and right-eye images for this stereo view were taken at about 12:30 p.m., local solar time on Mars. The scene appears three-dimensional when seen through blue-red glasses.The view is to the north northeast of the lander. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by JPL, Pasadena, Calif. Spacecraft development was by Lockheed Martin Space Systems, Denver.

  6. KIT polymorphisms and mutations determine responses of neoplastic mast cells to bafetinib (INNO-406).

    Science.gov (United States)

    Peter, Barbara; Hadzijusufovic, Emir; Blatt, Katharina; Gleixner, Karoline V; Pickl, Winfried F; Thaiwong, Tuddow; Yuzbasiyan-Gurkan, Vilma; Willmann, Michael; Valent, Peter

    2010-09-01

    Advanced systemic mastocytosis (SM) is characterized by uncontrolled growth of neoplastic mast cells (MC) and drug resistance. The tyrosine kinase receptor KIT is often mutated and activated and thus contributes to malignant growth of MC. Therefore, KIT-targeting drugs are currently tested for their ability to block growth of malignant MC. We determined the effects of the multikinase inhibitor INNO-406 (bafetinib) on primary neoplastic MC, the canine mastocytoma cell line C2, the human MC leukemia cell line HMC-1.1 bearing the KIT mutant V560G, and HMC-1.2 cells harboring KIT V560G and KIT D816V. INNO-406 was found to inhibit proliferation in HMC-1.1 cells (IC(50): 30-40 nM), but not in HMC-1.2 cells or primary neoplastic cells in patients with KIT D816V-positive SM. In canines, growth-inhibitory effects of INNO-406 were seen in C2 cells (IC(50): 50-100 nM) exhibiting a KIT exon 11 internal tandem-duplication and in primary neoplastic MC harboring wild-type exon 11, whereas no effects were seen in MC exhibiting a polymorphism at amino acid 581 in exon 11. INNO-406 was found to block KIT phosphorylation and expression in HMC-1.1 cells and C2 cells, but not in HMC-1.2 cells, whereas Lyn-phosphorylation was blocked by INNO-406 in all types of MC. In neoplastic MC, the major target of INNO-406 appears to be KIT. Drug responses may depend on the presence and type of KIT mutation. In human MC, the KIT D816V mutant introduces resistance, and in canine mastocytomas, an exon 11 polymorphism may be indicative of resistance against INNO-406.

  7. Effect of planecta and ROSE™ on the frequency characteristics of blood pressure-transducer kits.

    Science.gov (United States)

    Fujiwara, Shigeki; Kawakubo, Yoshifumi; Mori, Satoshi; Tachihara, Keiichi; Toyoguchi, Izumi; Yokoyama, Takeshi

    2015-12-01

    Pressure-transducer kits have frequency characteristics such as natural frequency and damping coefficient, which affect the monitoring accuracy. The aim of the present study was to investigate the effect of planecta ports and a damping device (ROSE™, Argon Medical Devices, TX, USA) on the frequency characteristics of pressure-transducer kits. The FloTrac sensor kit (Edwards Lifesciences, CA, USA) and the DTXplus transducer kit (Argon Medical Devices) were prepared with planecta ports, and their frequency characteristics were tested with or without ROSE™. The natural frequency and damping coefficient of each kit were obtained using frequency characteristics analysis software and evaluated by plotting them on the Gardner's chart. By inserting a planecta port, the natural frequency markedly decreased in both the FloTrac sensor kit (from 40 to 22 Hz) and the DTXplus transducer kit (from 35 to 22 Hz). In both kits with one planecta port, the damping coefficient markedly increased by insertion of ROSE™ from 0.2 to 0.5, optimising frequency characteristics. In both kits with two planecta ports, however, the natural frequency decreased from 22 to 12 Hz. The damping coefficient increased from 0.2 to 0.8 by insertion of ROSE™; however, optimisation was not achieved even by ROSE™ insertion. Planecta ports decrease the natural frequency of the kit. ROSE™ is useful to optimise the frequency characteristics in the kits without or with one planecta port. However, optimisation is difficult with two or more planecta ports, even with the ROSE™ device.

  8. Expression of c-kit in common benign and malignant breast lesions.

    Science.gov (United States)

    Kondi-Pafiti, Agatha; Arkadopoulos, Nikolaos; Gennatas, Constantinos; Michalaki, Vassiliki; Frangou-Plegmenou, Matrona; Chatzipantelis, Paschalis

    2010-01-01

    c-kit (CD117) is a transmembrane tyrosine kinase that acts as a type III receptor for mast cell growth factor. In recent years, the role of c-kit in the development of preinvasive and invasive breast carcinomas has been investigated. The aim of our study was to detect c-kit expression in the entire spectrum of common benign and malignant breast lesions in correlation with a well-studied myoepithelial or stem-cell like marker (p63). We evaluated 270 cases of benign and malignant breast lesions including fibrocystic disease, fibroadenoma, sclerosing adenosis, atypical ductal hyperplasia, ductal/lobular carcinoma in situ, and ductal/lobular/mixed type carcinoma. C-kit staining was evaluated in the cytoplasm/cell membrane in epithelial and myoepithelial cells and p63 in the nuclei of myoepithelial cells. c-kit was highly expressed (85.3%) in benign lesions (fibrocystic disease, sclerosing adenosis, fibroadenoma), and p63 expression was 95.5% in the aforementioned lesions. c-kit distribution in preinvasive and invasive lesions was as follows: ductal/lobular carcinoma in-situ, 43%/35%; ductal/lobular carcinoma, 36%/39%; and mixed type carcinoma, 20%. c-kit was highly expressed in myofibroblast/fibroblast cells only in grade III ductal/lobular carcinomas. c-kit was totally absent in stromal cells in benign lesions and in situ carcinomas whereas expression was weak in grade I and II carcinomas. Combined overexpression of c-kit and p63 is indicative of benign breast lesions. In contrast, there is reduced expression of c-kit in in situ and invasive breast carcinomas, with simultaneous overexpression in the stromal cells. This suggests that c-kit may play a role in breast cancer progression.

  9. Nectar and pollen production in Arabis procurrens Waldst. & Kit. and Iberis sempervirens L. (Brassicaceae

    Directory of Open Access Journals (Sweden)

    Monika Strzałkowska-Abramek

    2016-04-01

    Full Text Available Ecological environment in urban areas is specific in many aspects. There are evidences that ornamental plants cultivated in local urban gardens may help in conservation of pollinators. In this study, the flowering pattern, the abundance of flowering, nectar and pollen production as well as insect visitation in Arabis procurrens Waldst. & Kit. and Iberis sempervirens L. were investigated. The species were grown in the UMCS Botanical Garden in Lublin, southeastern Poland. Arabis procurrens bloomed from the middle of April until middle of May and I. sempervirens from the end of April until middle of June. In both species, most flowers opened in the morning hours (40–45% of total were opened by 8:00 h GMT + 2 h. The average sugar yield of A. procurrens was ca. 53% lower compared to I. sempervirens (mean = 1.08 g/m2 and 2.32 g/m2, respectively. In both species, considerable differences in the amount of produced sugars were noted between years. The mass of pollen produced in the flowers of A. procurrens was approx. 35% lower compared to that of I. sempervirens (mean = 0.06 mg and 0.09 mg per flower, respectively. Pollen produced per unit area was correlated with the number of flowers. On average, the species produced 1.46 g (A. procurrens and 2.54 g (I. sempervirens of pollen per 1 m2. The flowers of A. procurrens attracted mainly dipterans (56.3% of total visitors, while I. sempervirens lured chiefly solitary bees (47.4% of total visitors, however in both cases, honeybees, bumblebees and lepidopterans were also recorded. The A. procurrens and I. sempervirens due to flowering in early spring period may be promoted for use in small gardens (rock or pot gardens for both aesthetic value and as plants that support insect visitors in nectar and pollen rewards.

  10. Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors.

    Science.gov (United States)

    Antonescu, Cristina R; Sommer, Gunhild; Sarran, Lisa; Tschernyavsky, Sylvia J; Riedel, Elyn; Woodruff, James M; Robson, Mark; Maki, Robert; Brennan, Murray F; Ladanyi, Marc; DeMatteo, Ronald P; Besmer, Peter

    2003-08-15

    Activating mutations of the KIT juxtamembrane region are the most common genetic events in gastrointestinal stromal tumors (GISTs) and have been noted as independent prognostic factors. The impact of KIT mutation in other regions, such as the extracellular or kinase domains, is not well-defined and fewer than 30 cases have been published to date. One hundred twenty GISTs, confirmed by KIT immunoreactivity, were evaluated for the presence of KIT exon 9, 11, 13, and 17 mutations. The relation between the presence/type of KIT mutation and clinicopathological factors was analyzed using Fisher's exact test and log-rank test. Forty-four % of the tumors were located in the stomach, 47% in the small bowel, 6% in the rectum, and 3% in the retroperitoneum. Overall, KIT mutations were detected in 78% of patients as follows: 67% in exon 11, 11% in exon 9, and none in exon 13 or 17. The types of KIT exon 11 mutations were heterogeneous and clustered in the classic "hot spot" at the 5' end of exon 11. Seven % of cases showed internal tandem duplications (ITD) at the 3' end of exon 11, in a region that we designate as a second hot spot for KIT mutations. Interestingly, these cases were associated with: female predominance, stomach location, occurrence in older patients, and favorable outcome. There were significant associations between exon 9 mutations and large tumor size (P < 0.001) and extragastric location (P = 0.02). Ten of these 13 patients with more than 1-year follow-up have developed recurrent disease. Most KIT-expressing GISTs show KIT mutations that are preferentially located within the classic hot spot of exon 11. In addition, we found an association between a second hot spot at the 3'end of exon 11, characterized by ITDs, and a subgroup of clinically indolent gastric GISTs in older females. KIT exon 9 mutations seem to define a distinct subset of GISTs, located predominantly in the small bowel and associated with an unfavorable clinical course.

  11. Beach rock from Goa Coast

    Digital Repository Service at National Institute of Oceanography (India)

    Setty, M.G.A.P.; Wagle, B.G.

    constituents of beach rock found along Goa coast is dealt with in detail. While discussing the various views on its origin, it is emphasized that the process of cementation is chiefly controlled by ground water evaporation, inorganic precipitation and optimum...

  12. The Chronology of Rock Art

    Indian Academy of Sciences (India)

    Such phases are tentatively ascribed to different archaeological cultures on the basis of the contextual availability, stylistic similarities and so on. Ethnographic analogies are also attempted in the dating of rock art .

  13. Chemical methods of rock analysis

    National Research Council Canada - National Science Library

    Jeffery, P. G; Hutchison, D

    1981-01-01

    A practical guide to the methods in general use for the complete analysis of silicate rock material and for the determination of all those elements present in major, minor or trace amounts in silicate...

  14. Heat production in granitic rocks

    DEFF Research Database (Denmark)

    Artemieva, Irina; Thybo, Hans; Jakobsen, Kiki

    2017-01-01

    Granitic rocks play special role in the dynamics and evolution of the Earth and its thermal regime. First, their compositional variability, reflected in the distribution of concentrations of radiogenic elements, provides constraints on global differentiation processes and large scale planetary...... evolution, where emplacement of granites is considered a particularly important process for the formation of continental crust. Second, heat production by radioactive decay is among the main heat sources in the Earth. Therefore knowledge of heat production in granitic rocks is pivotal for thermal modelling...... of the continental lithosphere, given that most radiogenic elements are concentrated in granitic rocks of the upper continental crust whereas heat production in rocks of the lower crust and lithospheric mantle is negligible. We present and analyze a new global database GRANITE2017 (with about 500 entries...

  15. Defending dreamer’s rock

    OpenAIRE

    Beck, Günter U.

    2007-01-01

    Defending dreamer’s rock : Geschichte, Geschichtsbewusstsein und Geschichtskultur im Native drama der USA und Kanadas. - Trier : WVT Wiss. Verl. Trier, 2007. - 445 S. - (CDE - Studies ; 14). - Zugl.: Augsburg, Univ., Diss., 2006

  16. Information contained within the large scale gas injection test (Lasgit) dataset exposed using a bespoke data analysis tool-kit

    International Nuclear Information System (INIS)

    Bennett, D.P.; Thomas, H.R.; Cuss, R.J.; Harrington, J.F.; Vardon, P.J.

    2012-01-01

    Document available in extended abstract form only. The Large Scale Gas Injection Test (Lasgit) is a field scale experiment run by the British Geological Survey (BGS) and is located approximately 420 m underground at SKB's Aespoe Hard Rock Laboratory (HRL) in Sweden. It has been designed to study the impact on safety of gas build up within a KBS-3V concept high level radioactive waste repository. Lasgit has been in almost continuous operation for approximately seven years and is still underway. An analysis of the dataset arising from the Lasgit experiment with particular attention to the smaller scale features and phenomenon recorded has been undertaken in parallel to the macro scale analysis performed by the BGS. Lasgit is a highly instrumented, frequently sampled and long-lived experiment leading to a substantial dataset containing in excess of 14.7 million datum points. The data is anticipated to include a wealth of information, including information regarding overall processes as well as smaller scale or 'second order' features. Due to the size of the dataset coupled with the detailed analysis of the dataset required and the reduction in subjectivity associated with measurement compared to observation, computational analysis is essential. Moreover, due to the length of operation and complexity of experimental activity, the Lasgit dataset is not typically suited to 'out of the box' time series analysis algorithms. In particular, the features that are not suited to standard algorithms include non-uniformities due to (deliberate) changes in sample rate at various points in the experimental history and missing data due to hardware malfunction/failure causing interruption of logging cycles. To address these features a computational tool-kit capable of performing an Exploratory Data Analysis (EDA) on long-term, large-scale datasets with non-uniformities has been developed. Particular tool-kit abilities include: the parameterization of signal variation in the dataset

  17. Stability of Dosage Forms in the Pharmaceutical Payload Aboard Space Missions

    Science.gov (United States)

    Du, Brian J.; Daniels, Vernie; Boyd, Jason L.; Crady, Camille; Satterfield, Rick; Younker, Diane R.; Putcha, Lakshmi

    2009-01-01

    Efficacious pharmaceuticals with adequate shelf lives are essential for successful space medical operations. Stability of pharmaceuticals, therefore, is of paramount importance for assuring the health and wellness of astronauts on future space exploration missions. Unique physical and environmental factors of space missions may contribute to the instability of pharmaceuticals, e.g., radiation, humidity and temperature variations. Degradation of pharmaceutical formulations can result in inadequate efficacy and/or untoward toxic effects, which could compromise astronaut safety and health. Methods: Four identical pharmaceutical payload kits containing 31 medications in different dosage forms (liquid, tablet, capsule, ointment and suppository) were transported to the International Space Station aboard the Space Shuttle (STS-121). One of the 4 kits was stored on the Shuttle and the other 3 were stored on the International Space Station (ISS) for return to Earth at 6-month interval aboard a pre-designated Shuttle flight for each kit. The kit stored on the Shuttle was returned to Earth aboard STS-121 and 2 kits from ISS were returned on STS 117 and STS-122. Results: Analysis of standard physical and chemical parameters of degradation was completed for pharmaceuticals returned by STS-121 after14 days, STS - 117 after11 months and STS 122 after 19 months storage aboard ISS. Analysis of all flight samples along with ground-based matching controls was completed and results were compiled. Conclusion: Evaluation of results from the shuttle (1) and ISS increments (2) indicate that the number of formulations degraded in space increased with duration of storage in space and was higher in space compared to their ground-based counterparts. Rate of degradation for some of the formulations tested was faster in space than on Earth. Additionally, some of the formulations included in the medical kits were unstable, more so in space than on the ground. These results indicate that the

  18. Predicting rock bursts in mines

    Science.gov (United States)

    Spall, H.

    1979-01-01

    In terms of lives lost, rock bursts in underground mines can be as hazardous as earthquakes on the surface. So it is not surprising that fo the last 40 years the U.S Bureau of Mines has been using seismic methods for detecting areas in underground mines where there is a high differential stress which could lead to structural instability of the rock mass being excavated.

  19. Evaluation of the instability problems in rock slopes surrounding historical Safranbolu by kinematic analysis

    Directory of Open Access Journals (Sweden)

    İnan Keskin

    2017-10-01

    Full Text Available Safranbolu which has high probability for slope-induced disasters is a very worthwhile settlement for our country and also for the world with its historical and cultural heritage. Finding out potential hazards that may affect the wealth of this world heritage city is very crucial. The historic Safranbolu is surrounded by very steep rock slopes, and occasionally instability occurs in the rock mass that forms these slopes. The rock blocks that are relaesed in various causes and shapes can damage the historic town living spaces by creating a source for the rock fallings and moving down the slope in these very steep slopes. The rock slopes were evaluated by kinematic analysis in order to reduce the mentioned damages and to reveal potential hazards. In the study, characteristics of mass that causes rock fallings are analysed, kinematic controlled instability types are determined considering the obtained data and characteristic of slopes.

  20. Thermally induced rock stress increment and rock reinforcement response

    International Nuclear Information System (INIS)

    Hakala, M.; Stroem, J.; Nujiten, G.; Uotinen, L.; Siren, T.; Suikkanen, J.

    2014-07-01

    This report describes a detailed study of the effect of thermal heating by the spent nuclear fuel containers on the in situ rock stress, any potential rock failure, and associated rock reinforcement strategies for the Olkiluoto underground repository. The modelling approach and input data are presented together repository layout diagrams. The numerical codes used to establish the effects of heating on the in situ stress field are outlined, together with the rock mass parameters, in situ stress values, radiogenic temperatures and reinforcement structures. This is followed by a study of the temperature and stress evolution during the repository's operational period and the effect of the heating on the reinforcement structures. It is found that, during excavation, the maximum principal stress is concentrated at the transition areas where the profile changes and that, due to the heating from the deposition of spent nuclear fuel, the maximum principal stress rises significantly in the tunnel arch area of NW/SW oriented central tunnels. However, it is predicted that the rock's crack damage (CD, short term strength) value of 99 MPa will not be exceeded anywhere within the model. Loads onto the reinforcement structures will come from damaged and loosened rock which is assumed in the modelling as a free rock wedge - but this is very much a worst case scenario because there is no guarantee that rock cracking would form a free rock block. The structural capacity of the reinforcement structures is described and it is predicted that the current quantity of the rock reinforcement is strong enough to provide a stable tunnel opening during the peak of the long term stress state, with damage predicted on the sprayed concrete liner. However, the long term stability and safety can be improved through the implementation of the principles of the Observational Method. The effect of ventilation is also considered and an additional study of the radiogenic heating effect on the brittle

  1. Thermally induced rock stress increment and rock reinforcement response

    Energy Technology Data Exchange (ETDEWEB)

    Hakala, M. [KMS Hakala Oy, Nokia (Finland); Stroem, J.; Nujiten, G.; Uotinen, L. [Rockplan, Helsinki (Finland); Siren, T.; Suikkanen, J.

    2014-07-15

    This report describes a detailed study of the effect of thermal heating by the spent nuclear fuel containers on the in situ rock stress, any potential rock failure, and associated rock reinforcement strategies for the Olkiluoto underground repository. The modelling approach and input data are presented together repository layout diagrams. The numerical codes used to establish the effects of heating on the in situ stress field are outlined, together with the rock mass parameters, in situ stress values, radiogenic temperatures and reinforcement structures. This is followed by a study of the temperature and stress evolution during the repository's operational period and the effect of the heating on the reinforcement structures. It is found that, during excavation, the maximum principal stress is concentrated at the transition areas where the profile changes and that, due to the heating from the deposition of spent nuclear fuel, the maximum principal stress rises significantly in the tunnel arch area of NW/SW oriented central tunnels. However, it is predicted that the rock's crack damage (CD, short term strength) value of 99 MPa will not be exceeded anywhere within the model. Loads onto the reinforcement structures will come from damaged and loosened rock which is assumed in the modelling as a free rock wedge - but this is very much a worst case scenario because there is no guarantee that rock cracking would form a free rock block. The structural capacity of the reinforcement structures is described and it is predicted that the current quantity of the rock reinforcement is strong enough to provide a stable tunnel opening during the peak of the long term stress state, with damage predicted on the sprayed concrete liner. However, the long term stability and safety can be improved through the implementation of the principles of the Observational Method. The effect of ventilation is also considered and an additional study of the radiogenic heating effect on the

  2. 76 FR 72935 - Amended Authorization of Emergency Use of Doxycycline Hyclate Tablet Emergency Kits for Eligible...

    Science.gov (United States)

    2011-11-28

    ...] Amended Authorization of Emergency Use of Doxycycline Hyclate Tablet Emergency Kits for Eligible United... to the Emergency Use Authorization (EUA) (the Authorization) for doxycycline hyclate tablet emergency... Doxycyline Hyclate Tablet Emergency Kits, as Amended In 2004, the Secretary of the Department of Homeland...

  3. Omid Early Intervention Resource Kit for Children with Autism Spectrum Disorders and Their Families

    Science.gov (United States)

    Samadi, Sayyed Ali; Mahmoodizadeh, Ameneh

    2014-01-01

    Omid early intervention resource kit containing information booklets on autism spectrum disorders (ASD) and related issues, five packs of tangible selected playthings and communication facilitating aids was developed and evaluated with 65 Iranian parents. Beside a pretest before the resource kit deliverance, parents in the control group took part…

  4. 21 CFR 864.9650 - Quality control kit for blood banking reagents.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Quality control kit for blood banking reagents... SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9650 Quality control kit for blood banking reagents. (a...

  5. Performances of Four Helicobacter pylori Serological Detection Kits Using Stool Antigen Test as Gold Standard.

    Science.gov (United States)

    Biranjia-Hurdoyal, Susheela D; Seetulsingh-Goorah, Sharmila P

    2016-01-01

    The aim was to determine the performances of four Helicobacter pylori serological detection kits in different target groups, using Amplified IDEIA™ Hp StAR™ as gold standard. Kits studied were Rapid Immunochromatoghraphic Hexagon, Helicoblot 2.1, an EIA IgG kit and EIA IgA kit. Stool and blood samples were collected from 162 apparently healthy participants (control) and 60 Type 2 diabetes mellitus (T2DM) patients. The performances of the four serological detection kits were found to be affected by gender, age, health status and ethnicity of the participants. In the control group, the Helicoblot 2.1 kit had the best performance (AUC = 0.85; ppoor performances. In the T2DM subgroup, the kits H2.1 and EIA IgG had best performances, with accuracies of 96.5% and 93.1% respectively. The performance of EIA IgG improved with adjustment of its cut-off value. The performances of the detection kits were affected by various factors which should be taken into consideration.

  6. c-Kit expression in somatosensory nuclei of lower medulla oblongata.

    Science.gov (United States)

    Pop, Elena; Mărdărescu, Mariana; Lazăr, M; Rusu, M C; Ion, Daniela Adriana

    2013-01-01

    Protein kinase signal-transduction pathways play critical roles in regulating nociception. The c-kit receptor contributes to pain regulation in the spinal cord and is present on both peripheral and central terminals. Expression of c-kit was demonstrated in human trigeminal and spinal ganglia. However, the brainstem expression of c-kit was overlooked. We aimed to evaluate it by immunohistochemistry, on eight samples of human lower medulla oblongata. We used two clones of CD117/c-kit antibodies, from different manufacturers, and neurofilament antibodies. Positive expression of CD117/c-kit was found within the spinal trigeminal nucleus, the gracilis, cuneate, and lateral cuneate nuclei, and within the olivary complex. CD117/c-kit positive interstitial networks of these nuclei were positively labeled with neurofilaments. CD117/c-kit labeled the olivary neurons, but not the magnocellular neurons of the trigeminal, gracilis and cuneate nuclei. c-kit interstitial systems of brainstem could play so an important role for the functional status along the somatosensory neural circuits.

  7. Procedures for Separations within Batches of Values, 1. The Orderly Tool Kit and Some Heuristics

    Science.gov (United States)

    1989-03-01

    separations within batches of values, I. The orderly tool kit and some heuristics by Thu Hoang* and John W. Tukey** *Universite Rene Descartes ...separations with batches of values, . The orderly tool kit and heuristics Thu Hoang* and John W. Tukey** *Universite Rene Descartes Laboratoire de

  8. From smells to stories : The design and evaluation of the smell memory kit

    NARCIS (Netherlands)

    Leret, Susana Camara; Visch, V.T.

    2017-01-01

    The study presented is a research through design of the motivational, story sharing effects of smell, within the context of addiction care. This investigation led to the co-design of the Smell Memory Kit: a kit using eight selected smells as motivational elements to evoke and share

  9. Year 2000 Readiness Kit: A Compilation of Y2K Resources for Schools, Colleges and Universities.

    Science.gov (United States)

    Department of Education, Washington, DC.

    This kit was developed to assist the postsecondary education community's efforts to resolve the Year 2000 (Y2K) computer problem. The kit includes a description of the Y2K problem, an assessment of the readiness of colleges and universities, a checklist for institutions, a Y2K communications strategy, articles on addressing the problem in academic…

  10. Preparation of imaging kits locally using indium-113 as a suitable short-lived generator product

    International Nuclear Information System (INIS)

    Hamid, Hamid Seidna

    1999-05-01

    In this study forty patients are selected to do brain , lung , bone , liver and spleen imaging. Patients were selected carefully in the bases of the imaging history disorders. Kits prepared and kept frozen in (- 20 degree C) eluent the generator and indium 113 products were added to each kit and imaging sorted out using gamma camera and analysed statistically

  11. Research Note The reliability of a field test kit for the detection and ...

    African Journals Online (AJOL)

    Research Note The reliability of a field test kit for the detection and the persistence of ... Open Access DOWNLOAD FULL TEXT ... The objectives were to test a field kit for practicality and reliability, to assess the spread of the bacteria among ...

  12. Pongase en accion! Materiales para actividades despues de la escuela (Get into Action! Afterschool Action Kit).

    Science.gov (United States)

    Afterschool Alliance, Washington, DC.

    Noting that after-school programs are a critical link to helping children become successful adults, this Spanish-language kit explains what after-school programs can and should do for young people and how to locate or start an after-school program. The kit provides a rationale for developing after-school programs, noting the number of children…

  13. The KIT-Split in South African English: A critical review | Bekker ...

    African Journals Online (AJOL)

    While the lack of full complementation and the presence of some minimal pairs in SAfE KIT was confirmed by and continued to attract the attention of some later commentators (e.g., Lass and Wright 1985, Taylor 1991), the meaning of the term 'KIT-Split' has, in the meantime, been tacitly reformulated to refer solely to the ...

  14. C-peptide comparative radioimmunoassays: a study of three commercial kits

    International Nuclear Information System (INIS)

    Villaume, C.; Beck, B.

    1983-01-01

    Plasma C-peptide immunoreactivity (CPR) was measured in 18 fasting subjects with three different commercial kits (RIA-mat C-peptide-, Byk-Mallinckrodt; RIA-gnost-hC-peptide, Hoechst-Behring; human C-peptide radioimmunoassay kit, Novo) The subjects were chosen as to cover a wide range of CPR concentrations (five healthy subjects, six obese subjects, three insulin-dependent diabetics, four normal subjects whose plasmas had been kept at - 20 0 C for periods of 16 or 36 months). CPR was measured with the Novo kit in eight other plasmas which were kept over a period of 36 months, with or without aprotinin. Good correlations have been established among the values found with the three kits. However, absolute concentration values for each subject as well as the dispersion of all plasma C-peptide values varied as a function of the kit used because of antibody specificity differences and because of the various separation methods. The normal range proposed changes with each kit and the blood CPR of a subject can be a normal, reduced or increased one, depending on the kit used. After several months of storage, plasma CPR degradation is observed with the three kits. A protease-inhibitor is necessary in order to avoid this C-peptide degradation due to the apparent existence of a plasma proteolytic enzyme

  15. HTML5 eLearning kit for dummies

    CERN Document Server

    Boumphrey, Frank

    2012-01-01

    Helping self-directed learners of all levels learn HTML5 If you want to develop and structure pages for the web, HTML5 is one of the tools you need. This invaluable eLearning kit steps you through learning HTML5, CSS3, and JavaScript. With this dynamic combination of a full-color printed book and a Dummies interactive eLearning course on CD, you'll find a wealth of information on HTML5. Featuring both written and animated step-by-step how-tos, practice labs, helpful videos, numerous examples, and a host of Dummies hints and tips, this package makes your learning process easier. Follow the mate

  16. Preparation of one-vial reduced anti-CEA kit

    International Nuclear Information System (INIS)

    Hamada, Elena Setuko; Muramoto, Emiko; Shiraishi, Emilia Mayumi; Silva, Licia Maria Britto da; Martins, Heidi Pinto; Silva, Constanca Pagano Goncalves da

    1996-01-01

    A rapid and reliable instant reduced anti-CEA lyophilized kit for labelling with 99m Tc was developed. Each vial contains 0.5 mg of reduced anti-CEA, 40 μg of mendronate (MDP), 2.75 μg stannous fluoride (Sn F 2 ) and 15 μ g p-aminobenzoic acid (PABA). Labeling efficiency and stability were higher than 95% and were determined by instant paper chromatography. Biodistribution studies were performed in normal isogenic BALB/c mice at 4,6 and 24 hours after intravenous administration of the radiolabelled product. The maximum amount of activity was accumulated in the liver followed by intestines and kidneys. (author)

  17. Software development kit for a compact cryo-refrigerator

    Science.gov (United States)

    Gardiner, J.; Hamilton, J.; Lawton, J.; Knight, K.; Wilson, A.; Spagna, S.

    2017-12-01

    This paper introduces a Software Development Kit (SDK) that enables the creation of custom software applications that automate the control of a cryo-refrigerator (Quantum Design model GA-1) in third party instruments. A remote interface allows real time tracking and logging of critical system diagnostics such as pressures, temperatures, valve states and run modes. The helium compressor scroll capsule speed and Gifford-McMahon (G-M) cold head speed can be manually adjusted over a serial communication line via a CAN interface. This configuration optimizes cooling power, while reducing wear on moving components thus extending service life. Additionally, a proportional speed control mode allows for automated throttling of speeds based on temperature or pressure feedback from a 3rd party device. Warm up and cool down modes allow 1st and 2nd stage temperatures to be adjusted without the use of external heaters.

  18. The development of radioimmunoassay kit for rat albumin

    International Nuclear Information System (INIS)

    Yuan Zhigang; Han Shiquan; Liu Yibing; Xu Wenge

    2006-01-01

    The Anti-rat albumin serum is prepared by immunized the sheep with rat albumin. A radioimmunoassay method is established for rat albumin. The measurement range of the assay is 1-50 mg/L, sensitivity of the assay is 0.12 mg/L, recovery rate is 97.8%- 108.4%. Intra- and inter-assay variation coefficients are <4.0% and <8.2% respectively. The correlation coefficients between measured and expected values are more than 0.990 after serial dilution of the urine samples with high concentrations of rat albumin. The kit for rat albumin might provide a convenience in exploitation of renal drugs and experimental in- jury of the kidney. (authors)

  19. Assay Validation For Quantitation of Sn 2+ In Radiopharmaceutical Kits

    International Nuclear Information System (INIS)

    Muthalib, A; Ramli, Martalena; Herlina; Sarmini, Endang; Suharmadi; Besari, Canti

    1998-01-01

    An assay validation for quantitation of Sn2+ in radiopharmaceutical kits based on indirect iodometric titration is described. The method is based on the oxidation of sn2+ using a known excess of iodine and the excess unreacted iodine titrated with thiosulphate. Typical analytical parameters considered in this assay validation are precision, accuracy, selectivity or specificity, range, and linearity. The precision of the analytical method is quit good represented by coefficient of variance in range of 1.0% to 6.9 %, for 10 runs of analysis except one analysis shows the coefficient of 10.2 %. The method has an accuracy of 95.6 % - 99 % as percent recoveries at theoretical Sn2+ amounts of 463 μg to 2318μg

  20. Studies on the production of insulin radio-immunoassay kit

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J R; Kim, T H; Kim, Y S [Korea Atomic Energy Research Inst., Seoul (Republic of Korea)

    1978-01-01

    Insulin was labelled with Iodine-125 in about 35% yield by applying the chloramine-T method. The specific activity of the labelled product was about 100 ..mu..Ci/ug. To use the labelled product for the radioimmunoassay of insulin, the well labelled fractions were selected through a starch gel electrophoresis autoradiography, elution, and subsequent incubations with insulin antibodies. The results of the standardizations using the well labelled insulin fractions for radioimmunoassay indicated that the ratio of the antibody bound (B) to the free (F) insulin-/sup 125/I is 0.2 to 1.6 in the standard insulin dose of up to 50 ..mu..U/ml, the relatively steep dose gradient. Kits were prepared and the stabilities were also checked.

  1. The Pandora software development kit for pattern recognition

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, J.S.; Thomson, M.A. [University of Cambridge, Cavendish Laboratory, Cambridge (United Kingdom)

    2015-09-15

    The development of automated solutions to pattern recognition problems is important in many areas of scientific research and human endeavour. This paper describes the implementation of the Pandora software development kit, which aids the process of designing, implementing and running pattern recognition algorithms. The Pandora Application Programming Interfaces ensure simple specification of the building-blocks defining a pattern recognition problem. The logic required to solve the problem is implemented in algorithms. The algorithms request operations to create or modify data structures and the operations are performed by the Pandora framework. This design promotes an approach using many decoupled algorithms, each addressing specific topologies. Details of algorithms addressing two pattern recognition problems in High Energy Physics are presented: reconstruction of events at a high-energy e{sup +}e{sup -} linear collider and reconstruction of cosmic ray or neutrino events in a liquid argon time projection chamber. (orig.)

  2. 125I-labeled radioimmunoassay kits for progesterone evaluated for use in an in vitro fertilization program

    International Nuclear Information System (INIS)

    Blight, L.F.; White, G.H.

    1983-01-01

    We have evaluated two commercially available 125 I radioimmunoassay kits (Diagnostic Products Corp., DPC; and Radioassay Systems Laboratories, RSL) for measurement of serum or plasma progesterone, to determine their suitability for use in in vitro fertilization programs. Both kits were suitably rapid for program requirements. Results by both were linear with concentration up to 60 nmol/L, and both had acceptable lower detection limits of 0.3 nmol/L. Kit-determined progesterone concentrations (y) for 100 patients' samples correlated well with results by our existing 3H radioimmunoassay method (y . 1.11x + 0.2, r . 0.965 for the DPC kit; y . 1.01x + 1.4, r . 0.974 for the RSL kit). Mean analytical recovery for the RSL kit was 116%, that for the DPC kit, 202%. Within-batch precision, expressed as the mean CV for three concentrations of progesterone, was 6.5% for the RSL kit, and 16.4% for the DPC kit; between-day CV was 8.1% for the RSL kit, 17.7% for the DPC kit. We conclude that the RSL kit provides a rapid, precise, and accurate assay for serum progesterone, suitable for use in a fertilization program, but do not recommend the DPC kit for either this purpose or the more general purpose of tracking menstrual cycles

  3. Empirical Assessment of the Mean Block Volume of Rock Masses Intersected by Four Joint Sets

    Science.gov (United States)

    Morelli, Gian Luca

    2016-05-01

    The estimation of a representative value for the rock block volume ( V b) is of huge interest in rock engineering in regards to rock mass characterization purposes. However, while mathematical relationships to precisely estimate this parameter from the spacing of joints can be found in literature for rock masses intersected by three dominant joint sets, corresponding relationships do not actually exist when more than three sets occur. In these cases, a consistent assessment of V b can only be achieved by directly measuring the dimensions of several representative natural rock blocks in the field or by means of more sophisticated 3D numerical modeling approaches. However, Palmström's empirical relationship based on the volumetric joint count J v and on a block shape factor β is commonly used in the practice, although strictly valid only for rock masses intersected by three joint sets. Starting from these considerations, the present paper is primarily intended to investigate the reliability of a set of empirical relationships linking the block volume with the indexes most commonly used to characterize the degree of jointing in a rock mass (i.e. the J v and the mean value of the joint set spacings) specifically applicable to rock masses intersected by four sets of persistent discontinuities. Based on the analysis of artificial 3D block assemblies generated using the software AutoCAD, the most accurate best-fit regression has been found between the mean block volume (V_{{{{b}}_{{m}} }}) of tested rock mass samples and the geometric mean value of the spacings of the joint sets delimiting blocks; thus, indicating this mean value as a promising parameter for the preliminary characterization of the block size. Tests on field outcrops have demonstrated that the proposed empirical methodology has the potential of predicting the mean block volume of multiple-set jointed rock masses with an acceptable accuracy for common uses in most practical rock engineering applications.

  4. StochKit2: software for discrete stochastic simulation of biochemical systems with events.

    Science.gov (United States)

    Sanft, Kevin R; Wu, Sheng; Roh, Min; Fu, Jin; Lim, Rone Kwei; Petzold, Linda R

    2011-09-01

    StochKit2 is the first major upgrade of the popular StochKit stochastic simulation software package. StochKit2 provides highly efficient implementations of several variants of Gillespie's stochastic simulation algorithm (SSA), and tau-leaping with automatic step size selection. StochKit2 features include automatic selection of the optimal SSA method based on model properties, event handling, and automatic parallelism on multicore architectures. The underlying structure of the code has been completely updated to provide a flexible framework for extending its functionality. StochKit2 runs on Linux/Unix, Mac OS X and Windows. It is freely available under GPL version 3 and can be downloaded from http://sourceforge.net/projects/stochkit/. petzold@engineering.ucsb.edu.

  5. Behaviour of mink kits and dams (Mustela vison) in the lactation period

    DEFF Research Database (Denmark)

    Brink, Anne-Line; Jeppesen, Leif Lau

    2005-01-01

    This study describes the development of the behaviour of mink kits and dams from the fourth to the eighth respectively seventh week after delivery. The study is based on scan observations of 72 mink dams and their kits at a conventional Danish mink farm. The kits started eating when they were about...... 30 d old. Drinking started almost 2 wk later. During these 2 wk there was a peak in the licking of saliva from the dam and of the inter-litter agonistic behaviour. A causal relationship between experienced thirst and agonistic behaviour is suggested. The kits' sucking declined to only 5% of the time...... budget in the seventh week and the stereotypy frequency of the dams increased to about 4% of the time budget. It is suggested that some dams are frustrated by the forced cohabitation with their nutritionally independent kits already in the seventh week and that this should be taken into account when...

  6. Overestimation of the 25(OH)D serum concentration with the automated IDS EIA kit.

    Science.gov (United States)

    Cavalier, Etienne; Huberty, Véronique; Cormier, Catherine; Souberbielle, Jean-Claude

    2011-02-01

    We have recently observed an increasing number of patients presenting very high serum levels of 25-hydroxyvitamin D [25(OH)D] (> 150 ng/mL), which, in all cases, had been measured with the IDS EIA kit adapted on different "open" automated platforms. We performed a comparison between the IDS EIA kit adapted on two different "open"automated platforms and the DiaSorin RIA. We found a systematic bias (higher levels with the IDS EIA kit) for concentrations more than 50-60 ng/mL that was less obvious when the IDS EIA was used in its manual procedure. We thus suggest to use the IDS EIA kit in its manual procedure rather than to adapt it on an automated platform, and to interpret cautiously a 25(OH)D greater than 100 ng/mL with this kit. Copyright © 2011 American Society for Bone and Mineral Research.

  7. Evaluation of Rock Bolt Support for Polish Hard Rock Mines

    Science.gov (United States)

    Skrzypkowski, Krzysztof

    2018-03-01

    The article presents different types of rock bolt support used in Polish ore mining. Individual point resin and expansion rock bolt support were characterized. The roof classes for zinc and lead and copper ore mines were presented. Furthermore, in the article laboratory tests of point resin rock bolt support in a geometric scale of 1:1 with minimal fixing length of 0.6 m were made. Static testing of point resin rock bolt support were carried out on a laboratory test facility of Department of Underground Mining which simulate mine conditions for Polish ore and hard coal mining. Laboratory tests of point resin bolts were carried out, especially for the ZGH Bolesław, zinc and lead "Olkusz - Pomorzany" mine. The primary aim of the research was to check whether at the anchoring point length of 0.6 m by means of one and a half resin cartridge, the type bolt "Olkusz - 20A" is able to overcome the load.The second purpose of the study was to obtain load - displacement characteristic with determination of the elastic and plastic range of the bolt. For the best simulation of mine conditions the station steel cylinders with an external diameter of 0.1 m and a length of 0.6 m with a core of rock from the roof of the underground excavations were used.

  8. Seismic response of rock joints and jointed rock mass

    International Nuclear Information System (INIS)

    Ghosh, A.; Hsiung, S.M.; Chowdhury, A.H.

    1996-06-01

    Long-term stability of emplacement drifts and potential near-field fluid flow resulting from coupled effects are among the concerns for safe disposal of high-level nuclear waste (HLW). A number of factors can induce drift instability or change the near-field flow patterns. Repetitive seismic loads from earthquakes and thermal loads generated by the decay of emplaced waste are two significant factors. One of two key technical uncertainties (KTU) that can potentially pose a high risk of noncompliance with the performance objectives of 10 CFR Part 60 is the prediction of thermal-mechanical (including repetitive seismic load) effects on stability of emplacement drifts and the engineered barrier system. The second KTU of concern is the prediction of thermal-mechanical-hydrological (including repetitive seismic load) effects on the host rock surrounding the engineered barrier system. The Rock Mechanics research project being conducted at the Center for Nuclear Waste Regulatory Analyses (CNWRA) is intended to address certain specific technical issues associated with these two KTUs. This research project has two major components: (i) seismic response of rock joints and a jointed rock mass and (ii) coupled thermal-mechanical-hydrological (TMH) response of a jointed rock mass surrounding the engineered barrier system (EBS). This final report summarizes the research activities concerned with the repetitive seismic load aspect of both these KTUs

  9. Squat Biomechanical Modeling Results from Exercising on the Hybrid Ultimate Lifting Kit

    Science.gov (United States)

    Gallo, Christopher A.; Thompson, William K.; Lewandowski, Beth E.; Jagodnik, Kathleen M.

    2016-01-01

    Long duration space travel will expose astronauts to extended periods of reduced gravity. Since gravity is not present to aid loading, astronauts will use resistive and aerobic exercise regimes for the duration of the space flight to minimize loss of bone density, muscle mass and aerobic capacity that occurs during exposure to a reduced gravity environment. Unlike the International Space Station (ISS), the area available for an exercise device in the next generation of spacecraft is limited and therefore compact resistance exercise device prototypes are being developed. The Advanced Resistive Exercise Device (ARED) currently on the ISS is being used as a benchmark for the functional performance of these new devices. Biomechanical data collection and computational modeling aid the device design process by quantifying the joint torques and the musculoskeletal forces that occur during exercises performed on the prototype devices. The computational models currently under development utilize the OpenSim software, an open source code for musculoskeletal modeling, with biomechanical input data from test subjects for estimation of muscle and joint loads. The subjects are instrumented with reflective markers for motion capture data collection while exercising on the Hybrid Ultimate Lifting Kit (HULK) prototype device. Ground reaction force data is collected with force plates under the feet and device loading is recorded through load cells internal to the HULK. Test variables include applied device load, narrow or wide foot stance, slow or fast cadence and the harness or long bar interface between the test subject and the device. Data is also obtained using free weights for a comparison to the resistively loaded exercise device. This data is input into the OpenSim biomechanical model, which has been scaled to match the anthropometrics of the test subject, to calculate the body loads. The focus of this presentation is to summarize the results from the full squat exercises

  10. 30 CFR 57.3461 - Rock bursts.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Rock bursts. 57.3461 Section 57.3461 Mineral...-Underground Only § 57.3461 Rock bursts. (a) Operators of mines which have experienced a rock burst shall— (1) Within twenty four hours report to the nearest MSHA office each rock burst which: (i) Causes persons to...

  11. Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site.

    Science.gov (United States)

    Antonescu, Cristina R; Viale, Agnes; Sarran, Lisa; Tschernyavsky, Sylvia J; Gonen, Mithat; Segal, Neil H; Maki, Robert G; Socci, Nicholas D; DeMatteo, Ronald P; Besmer, Peter

    2004-05-15

    Gastrointestinal stromal tumors (GISTs) are specific KIT expressing and KIT-signaling driven mesenchymal tumors of the human digestive tract, many of which have KIT-activating mutations. Previous studies have found a relatively homogeneous gene expression profile in GIST, as compared with other histological types of sarcomas. Transcriptional heterogeneity within clinically or molecularly defined subsets of GISTs has not been previously reported. We tested the hypothesis that the gene expression profile in GISTs might be related to KIT genotype and possibly to other clinicopathological factors. An HG-U133A Affymetrix chip (22,000 genes) platform was used to determine the variability of gene expression in 28 KIT-expressing GIST samples from 24 patients. A control group of six intra-abdominal leiomyosarcomas was also included for comparison. Statistical analyses (t tests) were performed to identify discriminatory gene lists among various GIST subgroups. The levels of expression of various GIST subsets were also linked to a modified version of the growth factor/KIT signaling pathway to analyze differences at various steps in signal transduction. Genes involved in KIT signaling were differentially expressed among wild-type and mutant GISTs. High gene expression of potential drug targets, such as VEGF, MCSF, and BCL2 in the wild-type group, and Mesothelin in exon 9 GISTs were found. There was a striking difference in gene expression between stomach and small bowel GISTs. This finding was validated in four separate tumors, two gastric and two intestinal, from a patient with familial GIST with a germ-line KIT W557R substitution. GISTs have heterogeneous gene expression depending on KIT genotype and tumor location, which is seen at both the genomic level and the KIT signaling pathway in particular. These findings may explain their variable clinical behavior and response to therapy.

  12. Low-cost indigenous radiopharmaceutical kits manufacturing capability: a successful work accomplished in Ethiopia

    International Nuclear Information System (INIS)

    Jorge, Y.; Noronha, O.P.D.

    1998-01-01

    Nuclear Medicine Unit at Black Lion Hospital is the only Nuclear Medicine service giving center in the country. We have been importing Radiopharmaceutical-kits for 10 subsequent years costly, with frequent irregularities, only limited Numbers of kits mainly for Liver, Brain, Thyroid and Kidney imagings. Most of the Nuclear Medicine (NM) diagnostic procedures were not undertaken at our unit, because of unavailability of vital Radiopharmaceutical-kits (Rp-kits) in the country since they were not manufactured in the country. In order to solve this long stranding problem of the country persistent efforts were made. The success in Rp-kits manufacturing indigenously has the advantage of disseminating the NM Technology with in the country also. With the continuous efforts made 7 Aqueous-Rp-kits were manufactured successfully in our unit viza-viz: 1) 99m Tc-s-colloid-for Liver imaging. 2) 99m Tc-DTPA-for Brain + Renal imaging. 3) 99m Tc-MDP-for Bone imaging, 4) 99m Tc-Tin (11) pyrophosphate for in-vivo R,B,C, labelling: (For the study of Blood-Pool and Myocardial Infarction), 5) 99m Tc-Tin(11) Gluconate for Brain + Kidney Static imaging. 6) 99m Tc-Tin(11) Phytate for Liver imaging. 7) 99m Tc-TBI for Myocardial perfusion study. Their physico-chemical behaving patterns were studied and the chemical and biological quality control procedures were conducted upon the indigenously produced kits at the National Drug Quality Control center and they were found to be sterile, apyrogenic and non-toxic. The efficiency of the kits was tested in many patients in our unit and found to be effective and reliable. Aqueous kits produced were observed to be as effective and reliable as their lyophilized counterparts with respect to their physico-chemical properties and biospecificity (organ specificity) but possessing short shelf lives unlike lyophilized kits. (author)

  13. Analysis of Western Australian zebra rock

    International Nuclear Information System (INIS)

    Clark, M.J.; Cashion, J.D.

    2000-01-01

    Full text: Zebra rock is a striking rock from the Ord River area of Western Australia which contains regularly spaced white and red-brown bands or rods. Its ease of working has made it popular for use in ornaments and costume jewellery. However, the mechanism for its formation has been a source of controversy for 75 years and is still not settled. Possible mechanisms proposed include slow sedimentation with regular addition of hydrated iron oxides, leaching of a reddish mudstone, post-depositional mobilisation and subsequent rhythmic precipitation of iron oxides from groundwaters, and accumulation of iron-containing minerals in ripple troughs. Loughnan and Roberts suggested a more detailed explanation and from a detailed mineralogical examination, including XRD, XRF, SEM and TEM, they concluded that the only major difference between the two coloured bands was the presence of hematite, α-Fe 2 O 3 . In an attempt to throw more light on the problem, we have taken 57 Fe Moessbauer spectra of samples from the two different coloured regions. As expected, the white coloured material contained little iron, giving a weak, broad single line spectrum at room temperature. At 78 K, the spectrum has split into a magnetic sextet which has not yet been positively identified. As expected from the XRD, the spectrum of the red part principally consists of a strong sextet due to hematite, although there is also a weak component from the phase in the white material. It is hoped that further analysis will help us to eliminate at least some of the proposed mechanisms for the formation of zebra rock

  14. Current status of crushed rock and whole rock column studies

    International Nuclear Information System (INIS)

    Vine, E.N.; Daniels, W.R.; Rundberg, R.S.; Thompson, J.L.

    1980-01-01

    Measurements on a large number of crushed rock columns of tuff, granite, and argillite are discussed. The isotopes 85 Sr, 137 Cs, 133 Ba, 141 Ce, 152 Eu, /sup 95m/Tc, and 233 U were used. Flow rates were varied from approx. 30 to approx. 30000 m/y. Other parameters studied include isotope concentration and atmosphere. The sorption ratios calculated were compared with batch sorption ratios on the same samples. Methods of studying the movement of radionuclides through whole rock cores are described. The problems associated with sealing the cores to prevent leaking along the exterior surface and one possible solution are discussed. The strontium sorption ratio obtained by elution of one solid tuff core is compared with the batch and crushed rock column sorption ratios

  15. Receptor tyrosine kinase (c-Kit inhibitors: a potential therapeutic target in cancer cells

    Directory of Open Access Journals (Sweden)

    Abbaspour Babaei M

    2016-08-01

    Full Text Available Maryam Abbaspour Babaei,1 Behnam Kamalidehghan,2,3 Mohammad Saleem,4–6 Hasniza Zaman Huri,1,7 Fatemeh Ahmadipour1 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB, Shahrak-e Pajoohesh, 3Medical Genetics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Department of Urology, 5Department of Laboratory Medicine and Pathology, Masonic Cancer Center, University of Minnesota, 6Section of Molecular Therapeutics & Cancer Health Disparity, The Hormel Institute, Austin, MN, USA; 7Clinical Investigation Centre, University Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, Malaysia Abstract: c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the concept that inhibiting c-Kit kinase activity can be a target for cancer therapy. The promising results of inhibition of c-Kit for treatment of cancers have been observed in some cancers such as gastrointestinal stromal tumor, acute myeloid leukemia, melanoma, and other tumors, and these results have encouraged attempts toward improvement of using c-Kit as a capable target for cancer therapy. This paper presents the findings of previous studies regarding c-Kit as a receptor tyrosine kinase and an oncogene, as well as its gene targets and signaling pathways in normal and cancer cells. The c-Kit gene location, protein structure, and the role of c-Kit in normal cell have been discussed. Comprehending the molecular mechanism underlying c-Kit-mediated tumorogenesis is consequently essential and may lead to the identification of future novel drug targets. The potential mechanisms by which c-Kit induces cellular transformation have been described. This study aims to elucidate the function of c-Kit

  16. Comparison of DNA extraction kits for detection of Burkholderia pseudomallei in spiked human whole blood using real-time PCR.

    Directory of Open Access Journals (Sweden)

    Nicole L Podnecky

    Full Text Available Burkholderia pseudomallei, the etiologic agent of melioidosis, is endemic in northern Australia and Southeast Asia and can cause severe septicemia that may lead to death in 20% to 50% of cases. Rapid detection of B. pseudomallei infection is crucial for timely treatment of septic patients. This study evaluated seven commercially available DNA extraction kits to determine the relative recovery of B. pseudomallei DNA from spiked EDTA-containing human whole blood. The evaluation included three manual kits: the QIAamp DNA Mini kit, the QIAamp DNA Blood Mini kit, and the High Pure PCR Template Preparation kit; and four automated systems: the MagNAPure LC using the DNA Isolation Kit I, the MagNAPure Compact using the Nucleic Acid Isolation Kit I, and the QIAcube using the QIAamp DNA Mini kit and the QIAamp DNA Blood Mini kit. Detection of B. pseudomallei DNA extracted by each kit was performed using the B. pseudomallei specific type III secretion real-time PCR (TTS1 assay. Crossing threshold (C T values were used to compare the limit of detection and reproducibility of each kit. This study also compared the DNA concentrations and DNA purity yielded for each kit. The following kits consistently yielded DNA that produced a detectable signal from blood spiked with 5.5×10(4 colony forming units per mL: the High Pure PCR Template Preparation, QIAamp DNA Mini, MagNA Pure Compact, and the QIAcube running the QIAamp DNA Mini and QIAamp DNA Blood Mini kits. The High Pure PCR Template Preparation kit yielded the lowest limit of detection with spiked blood, but when this kit was used with blood from patients with confirmed cases of melioidosis, the bacteria was not reliably detected indicating blood may not be an optimal specimen.

  17. Validation of the AmpFlSTR« SEfiler Plus(TM) PCR Amplification kit for forensic STR analysis

    DEFF Research Database (Denmark)

    Fredslund, Stine Frisk; Mogensen, Helle Smidt; Morling, Niels

    2009-01-01

    Validation of the AmpFlSTR« SEfiler Plus(TM) PCR Amplification kit with 29 and 30 PCR cycles for forensic STR analysis demonstrated that the kit had fewer artefacts than the AmpFlSTR« SGM Plus(TM) kit (28 PCR cycles). The SEfiler Plus kit was more sensitive and devoid of colour artefacts, but sho......, but showed more stutters, drop-ins, drop-outs and allelic imbalances...

  18. The preparation and clinical use of a radioimmunoassay CA125 kit for the diagnosis of epithelial ovarian cancer

    International Nuclear Information System (INIS)

    Liu Wenshu

    1992-01-01

    A self-made radioimmunoassay CA125 kit (using OC125 monoclonal antibody ascites offered by Dr. Bast Laboratory which was purified, solidified and labelled with 125 I) was used for serum determination in 80 patients with epithelial ovarian cancer and in 40 standard antigen samples. The results demonstrated a statistically significant correlation between our self-made CA 125 kit and an imported CENTOCOR CA125 kit (P 125 kit is very useful in monitoring epithelial ovarian cancer

  19. Combined radioimmunoassay of HBs-antigen and anti-HBs using the Biotest combRIA-Au kit

    International Nuclear Information System (INIS)

    Kselikova, M.; Novak, J.; Urbankova, J.

    1979-01-01

    Hepatitis B antigen and antibody were determined simultaneously by radioimmunoassay using the Biotest combRIA-Au kit. The results in determining antigens and antibodies in sera with a known content of these substances by this kit nearly equal those of isolated determinations of antigen by the Abbott AUSRIA II-125 kit, and of antibody by the Abbott AUSAB kit, resp., except for a negligible number of sera with a very low content of either antigen or antibody. (author)

  20. Rock Pore Structure as Main Reason of Rock Deterioration

    Directory of Open Access Journals (Sweden)

    Ondrášik Martin

    2014-03-01

    Full Text Available Crashed or dimensional rocks have been used as natural construction material, decoration stone or as material for artistic sculptures. Especially old historical towns not only in Slovakia have had experiences with use of stones for construction purposes for centuries. The whole buildings were made from dimensional stone, like sandstone, limestone or rhyolite. Pavements were made especially from basalt, andesite, rhyolite or granite. Also the most common modern construction material - concrete includes large amounts of crashed rock, especially limestone, dolostone and andesite.

  1. Preparation of acid-base bifunctional mesoporous KIT-6 (KIT: Korea Advanced Institute of Science and Technology) and its catalytic performance in Knoevenagel reaction

    International Nuclear Information System (INIS)

    Xu, Ling; Wang, Chunhua; Guan, Jingqi

    2014-01-01

    Acid-base bifunctional mesoporous catalysts Al-KIT-6-NH 2 containing different aluminum content have been synthesized through post synthetic grafting method. The materials were characterized by X-ray diffraction (XRD), scanning electron micrographs (SEM), transmission electron micrographs (TEM), Fourier-transform infrared spectroscopy (FTIR), IR spectra of pyridine adsorption, NH 3 -TPD and TG analysis. The characterization results indicated that the pore structure of KIT-6 was well kept after the addition of aluminum and grafting of aminopropyl groups. The acid amount of Al-KIT-6 increased with enhancing aluminum content. Catalytic results showed that weak acid and weak base favor the Knoevenagel reaction, while catalysts with strong acid and weak base exhibited worse catalytic behavior. - Graphical abstract: The postulated steps of mechanism for the acid-base catalyzed process are as follows: (1) the aldehyde gets activated by the surface acidic sites which allow the amine undergoes nucleophilic to attack the carbonyl carbon of benzaldehyde. (2) Water is released in the formation of imine intermediate. (3) The ethyl cyanoacetate reacts with the intermediate. (4) The benzylidene ethyl cyanoacetate is formed and the amine is regenerated. - Highlights: • KIT-6 and Al-KIT-6-NH 2 with different Si/Al ratios has been successfully prepared. • 79.4% Yield was obtained over 46-Al-KIT-6-NH 2 within 20 min in Knoevenagel reaction. • Low Al-content Al-KIT-6-NH 2 shows better catalytic stability than high Al-content catalysts. • There is acid-base synergistic effect in Knoevenagel reaction

  2. Preparation of acid-base bifunctional mesoporous KIT-6 (KIT: Korea Advanced Institute of Science and Technology) and its catalytic performance in Knoevenagel reaction

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Ling [College of Chemistry and Chemical Engineering, Inner Mongolia University for Nationalities, Tongliao 028000 (China); Wang, Chunhua [Key Laboratory of Surface and Interface Chemistry of Jilin Province, College of Chemistry, Jilin University, Changchun 130023 (China); Guan, Jingqi, E-mail: guanjq@jlu.edu.cn [Key Laboratory of Surface and Interface Chemistry of Jilin Province, College of Chemistry, Jilin University, Changchun 130023 (China)

    2014-05-01

    Acid-base bifunctional mesoporous catalysts Al-KIT-6-NH{sub 2} containing different aluminum content have been synthesized through post synthetic grafting method. The materials were characterized by X-ray diffraction (XRD), scanning electron micrographs (SEM), transmission electron micrographs (TEM), Fourier-transform infrared spectroscopy (FTIR), IR spectra of pyridine adsorption, NH{sub 3}-TPD and TG analysis. The characterization results indicated that the pore structure of KIT-6 was well kept after the addition of aluminum and grafting of aminopropyl groups. The acid amount of Al-KIT-6 increased with enhancing aluminum content. Catalytic results showed that weak acid and weak base favor the Knoevenagel reaction, while catalysts with strong acid and weak base exhibited worse catalytic behavior. - Graphical abstract: The postulated steps of mechanism for the acid-base catalyzed process are as follows: (1) the aldehyde gets activated by the surface acidic sites which allow the amine undergoes nucleophilic to attack the carbonyl carbon of benzaldehyde. (2) Water is released in the formation of imine intermediate. (3) The ethyl cyanoacetate reacts with the intermediate. (4) The benzylidene ethyl cyanoacetate is formed and the amine is regenerated. - Highlights: • KIT-6 and Al-KIT-6-NH{sub 2} with different Si/Al ratios has been successfully prepared. • 79.4% Yield was obtained over 46-Al-KIT-6-NH{sub 2} within 20 min in Knoevenagel reaction. • Low Al-content Al-KIT-6-NH{sub 2} shows better catalytic stability than high Al-content catalysts. • There is acid-base synergistic effect in Knoevenagel reaction.

  3. Hot dry rock heat mining

    International Nuclear Information System (INIS)

    Duchane, D.V.

    1992-01-01

    Geothermal energy utilizing fluids from natural sources is currently exploited on a commercial scale at sites around the world. A much greater geothermal resource exists, however, in the form of hot rock at depth which is essentially dry. This hot dry rock (HDR) resource is found almost everywhere, but the depth at which usefully high temperatures are reached varies from place to place. The technology to mine the thermal energy from HDR has been under development for a number of years. Using techniques adapted from the petroleum industry, water is pumped at high pressure down an injection well to a region of usefully hot rock. The pressure forces open natural joints to form a reservoir consisting of a small amount of water dispensed in a large volume of hot rock. This reservoir is tapped by second well located at some distance from the first, and the heated water is brought to the surface where its thermal energy is extracted. The same water is then recirculated to mine more heat. Economic studies have indicated that it may be possible to produce electricity at competitive prices today in regions where hot rock is found relatively close to the surface

  4. 75 FR 13292 - Determination That HalfLytely and Bisacodyl Tablets Bowel Prep Kit (Containing 4 Bisacodyl...

    Science.gov (United States)

    2010-03-19

    ... determined that HALFLYTELY AND BISACODYL TABLETS BOWEL PREP KIT (polyethylene glycol (PEG) 3350, sodium... kits containing PEG-3350, sodium chloride, sodium bicarbonate, and potassium chloride for oral solution... whether HALFLYTELY AND BISACODYL TABLETS BOWEL PREP KIT (PEG-3350, sodium chloride, sodium bicarbonate...

  5. Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase

    DEFF Research Database (Denmark)

    Zadjali, Fahad; Pike, Ashley C W; Vesterlund, Mattias

    2011-01-01

    to substrate residue position pY+6 and envelopes the c-KIT phosphopeptide with a large BG loop insertion that contributes significantly to substrate interaction. We demonstrate that SOCS6 has ubiquitin ligase activity toward c-KIT and regulates c-KIT protein turnover in cells. Our data support a role of SOCS6...

  6. Industrial tests of rock consolidation for fighting floor swelling

    Energy Technology Data Exchange (ETDEWEB)

    Pirskii, A A; Stovpnik, S N [KPI (USSR)

    1990-04-01

    Reports on investigations into the mechanism of floor swelling in main roadways and into rock mass stabilization by consolidating fluid injection combined with blasting. The principal cause of deterioration in the stability of workings is considered to be the state of stress in the rock mass, rock destruction in side walls where rock blocks are being pressed into the floor while the floor rock is squeezed out into the working space. A case study of fluid injection combined with blasting applied in several mines in the Donbass is presented where holes were drilled 1.5-3 m deep and explosive charges of 0.07-0.1 kg/hole and injection of hardening solutions (0.56-0.83 m{sup 3}/m of workings) were applied. As a result floor swelling rates were reduced by up to about 5 times (e.g. from 2.5 mm/d to 0.5 mm/d.). The period of maintenence free upkeep of workings was extended to 6-8 years. The economic effect in maintenance of 1 m of workings was 11.7 rubles for floor consolidation without sidewall bolting and 51.4 rubles for floor consolidation combined with sidewall bolting. Recommendations that concern the technology of floor consolidation by fluid injection and blasting are made. 4 refs.

  7. Finite element simulations of two rock mechanics tests

    International Nuclear Information System (INIS)

    Dahlke, H.J.; Lott, S.A.

    1986-04-01

    Rock mechanics tests are performed to determine in situ stress conditions and material properties of an underground rock mass. To design stable underground facilities for the permanent storage of high-level nuclear waste, determination of these properties and conditions is a necessary first step. However, before a test and its associated equipment can be designed, the engineer needs to know the range of expected values to be measured by the instruments. Sensitivity studies by means of finite element simulations are employed in this preliminary design phase to evaluate the pertinent parameters and their effects on the proposed measurements. The simulations, of two typical rock mechanics tests, the plate bearing test and the flat-jack test, by means of the finite element analysis, are described. The plate bearing test is used to determine the rock mass deformation modulus. The flat-jack test is used to determine the in situ stress conditions of the host rock. For the plate bearing test, two finite element models are used to simulate the classic problem of a load on an elastic half space and the actual problem of a plate bearing test in an underground tunnel of circular cross section. For the flat-jack simulation, a single finite element model is used to simulate both horizontal and vertical slots. Results will be compared to closed-form solutions available in the literature

  8. ROCK MASS DAMAGED ZONE CAUSED BY BLASTING DURING TUNNEL EXCAVATION

    Directory of Open Access Journals (Sweden)

    Hrvoje Antičević

    2012-07-01

    Full Text Available Design of underground spaces, including tunnels, and repositories for radioactive waste include the application of the same or similar technologies. Tunnel excavation by blasting inevitably results in the damage in the rock mass around the excavation profile. The damage in the rock mass immediately next to the tunnel profile emerges as the expanding of the existing cracks and the appearance of new cracks, i.e. as the change of the physical and-mechanical properties of the rock mass. Concerning the design of deep geological repositories, requirements in terms of damaged rock are the same or more rigorous than for the design of tunnel. The aforementioned research is directed towards determining the depth of damage zone caused by blasting. The depth of the damage zone is determined by measuring the changes of physical and-mechanical properties of the rock mass around the tunnel excavation profile. By this research the drilling and blasting parameters were correlated with the depth and size of the damage zone (the paper is published in Croatian.

  9. Thermal expansion of granite rocks

    International Nuclear Information System (INIS)

    Stephansson, O.

    1978-04-01

    The thermal expansion of rocks is strongly controlled by the thermal expansion of the minerals. The theoretical thermal expansion of the Stripa Granite is gound to be 21 . 10 -6 [deg C] -1 at 25 deg C and 38 . 10 -6 [deg C] -1 at 400 deg C. The difference in expansion for the rock forming minerals causes micro cracking at heating. The expansion due to micro cracks is found to be of the same order as the mineral expansion. Most of the micro cracks will close at pressures of the order of 10 - 20 MPa. The thermal expansion of a rock mass including the effect of joints is determined in the pilot heater test in the Stripa Mine

  10. Epigenetic regulation of cardiac progenitor cells marker c-kit by stromal cell derived factor-1α.

    Directory of Open Access Journals (Sweden)

    Zhongpu Chen

    Full Text Available BACKGROUND: Cardiac progenitor cells (CPCs have been proven suitable for stem cell therapy after myocardial infarction, especially c-kit(+CPCs. CPCs marker c-kit and its ligand, the stem cell factor (SCF, are linked as c-kit/SCF axis, which is associated with the functions of proliferation and differentiation. In our previous study, we found that stromal cell-derived factor-1α (SDF-1α could enhance the expression of c-kit. However, the mechanism is unknown. METHODS AND RESULTS: CPCs were isolated from adult mouse hearts, c-kit(+ and c-kit(- CPCs were separated by magnetic beads. The cells were cultured with SDF-1α and CXCR4-selective antagonist AMD3100, and c-kit expression was measured by qPCR and Western blotting. Results showed that SDF-1α could enhance c-kit expression of c-kit(+CPCs, made c-kit(-CPCs expressing c-kit, and AMD3100 could inhibit the function of SDF-1α. After the intervention of SDF-1α and AMD3100, proliferation and migration of CPCs were measured by CCK-8 and transwell assay. Results showed that SDF-1α could enhance the proliferation and migration of both c-kit(+ and c-kit(- CPCs, and AMD3100 could inhibit these functions. DNA methyltransferase (DNMT mRNA were measured by qPCR, DNMT activity was measured using the DNMT activity assay kit, and DNA methylation was analyzed using Sequenom's MassARRAY platform, after the CPCs were cultured with SDF-1α. The results showed that SDF-1α stimulation inhibited the expression of DNMT1 and DNMT3β, which are critical for the maintenance of regional DNA methylation. Global DNMT activity was also inhibited by SDF-1α. Lastly, SDF-1α treatment led to significant demethylation in both c-kit(+ and c-kit(- CPCs. CONCLUSIONS: SDF-1α combined with CXCR4 could up-regulate c-kit expression of c-kit(+CPCs and make c-kit(-CPCs expressing c-kit, which result in the CPCs proliferation and migration ability improvement, through the inhibition of DNMT1 and DNMT3β expression and global DNMT

  11. [Effect comparison between two ELISA kits in IgG antibody detection of Echinococcus granulosus].

    Science.gov (United States)

    Chu, Yan-Hong; Cai, Yu-Chun; Ai, Lin; Lu, Yan; Zhang, Jia; Chen, Jia-Xu

    2013-06-01

    To compare the effects of two ELISA kits on IgG antibody detection of human Echinococcus granulosus. A Total of 134 sera of patients with echinococcosis, paragonimiasis westermani, clonorchiasis sinensis, schistosomiasis japonica, and cysticercosis cellulosae, and normal persons were detected by two IgG ELISA kits produced by different companies. Furthermore, the specificity, sensitivity and cross reactivity were counted and analyzed statistically. The sensitivity and specificity were extremely high of the two kits as 100.00%. The cross-reactivity rates were 25.00% (paragonimiasis westermani), 26.09% (clonorchiasis sinensis), 10.00% (schistosomiasis japonica), and 87.5% (cysticercosis), respectively, by using the kit produced by the Combined Company in Shenzhen; the cross-reactivity rates were 5.00% (paragonimiasis westermani), 13.04% (clonorchiasis sinensis), 20.00% (schistosomiasis japonica), and 93.75% (cysticercosis) respectively, by using the kit produced by Haitai Company in Zhuhai. In addition, there was a significant difference of Paragonimus westermani detection (P 0.05) between the two kits. Both ELISA kits on IgG antibody detection of human Echinococcus granulosus have the advantages of a high sensitivity, specificity, convenience and high-speed. However, it is also in urgent need to further solve the cross-reactivity of Echinococcus granulosus with other parasites, in order to improve the accuracy of early diagnosis.

  12. Mutational status of EGFR and KIT in thymoma and thymic carcinoma.

    Science.gov (United States)

    Yoh, Kiyotaka; Nishiwaki, Yutaka; Ishii, Genichiro; Goto, Koichi; Kubota, Kaoru; Ohmatsu, Hironobu; Niho, Seiji; Nagai, Kanji; Saijo, Nagahiro

    2008-12-01

    This study was conducted to evaluate the prevalence of EGFR and KIT mutations in thymomas and thymic carcinomas as a means of exploring the potential for molecularly targeted therapy with tyrosine kinase inhibitors. Genomic DNA was isolated from 41 paraffin-embedded tumor samples obtained from 24 thymomas and 17 thymic carcinomas. EGFR exons 18, 19, and 21, and KIT exons 9, 11, 13, and 17, were analyzed for mutations by PCR and direct sequencing. Protein expression of EGFR and KIT was evaluated immunohistochemically. EGFR mutations were detected in 2 of 20 thymomas, but not in any of the thymic carcinomas. All of the EGFR mutations detected were missense mutations (L858R and G863D) in exon 21. EGFR protein was expressed in 71% of the thymomas and 53% of the thymic carcinomas. The mutational analysis of KIT revealed only a missense mutation (L576P) in exon 11 of one thymic carcinoma. KIT protein was expressed in 88% of the thymic carcinomas and 0% of the thymomas. The results of this study indicate that EGFR and KIT mutations in thymomas and thymic carcinomas are rare, but that many of the tumors express EGFR or KIT protein.

  13. Measurement of free thyroxine and free triiodothyronine concentrations by DPC RIA kits

    International Nuclear Information System (INIS)

    Kasagi, Kanji; Kousaka, Tadako; Hatabu, Hiroto; Tokuda, Yasutaka; Iida, Yasuhiro; Konishi, Junji

    1988-01-01

    'DPC RIA' kits for measuring free triiodothyronine (T3) and free thyroxine (T4) were fundamentally and clinically studied. Standard curves for incubation temperature and time were favorable. The present kits yielded satisfactory precision and reproducibility. The upper and lower limits of the normal range for T4 were 0.88 ng/dl and 2.08 ng/dl, respectively. The serum concentration of T4 was 3.91 ng/dl or more for hyperthyroidism and 0.57 ng/dl or less for hypothyroidism, allowing discrimination between the two diseases. For T3, the upper and lower limits of the normal range were 1.45 ng/dl and 3.45 ng/dl, respectively. In pregnant women and patients with decreased or increased levels of thyroxine binding globulin (TBG), the serum T3 concentration lay within the normal range. Low free T4 and T3 levels were found in 22 % and 67 %, respectively, of patients with serious non-thyroidal illness (NTI). There was a good correlation between the present kits and the other commercially available kits. Measurements of free T3 and T4 obtained by ''Amerlex RIA'' kits tended to be lower than those by the present kits in pregnant women and NTI patients with hypoalbuminemia. In view of the simplified procedure, satisfactory precision and reproducibility, and the lack of influences of serum albumin and TBG, the present kits have a potential in routine use. (Namekawa, K.)

  14. Hematopoietic Kit Deficiency, rather than Lack of Mast Cells, Protects Mice from Obesity and Insulin Resistance.

    Science.gov (United States)

    Gutierrez, Dario A; Muralidhar, Sathya; Feyerabend, Thorsten B; Herzig, Stephan; Rodewald, Hans-Reimer

    2015-05-05

    Obesity, insulin resistance, and related pathologies are associated with immune-mediated chronic inflammation. Kit mutant mice are protected from diet-induced obesity and associated co-morbidities, and this phenotype has previously been attributed to their lack of mast cells. We performed a comprehensive metabolic analysis of Kit-dependent Kit(W/Wv) and Kit-independent Cpa3(Cre/+) mast-cell-deficient mouse strains, employing diet-induced or genetic (Lep(Ob/Ob) background) models of obesity. Our results show that mast cell deficiency, in the absence of Kit mutations, plays no role in the regulation of weight gain or insulin resistance. Moreover, we provide evidence that the metabolic phenotype observed in Kit mutant mice, while independent of mast cells, is immune regulated. Our data underscore the value of definitive mast cell deficiency models to conclusively test the involvement of this enigmatic cell in immune-mediated pathologies and identify Kit as a key hematopoietic factor in the pathogenesis of metabolic syndrome. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Direct qPCR quantification using the Quantifiler(®) Trio DNA quantification kit.

    Science.gov (United States)

    Liu, Jason Yingjie

    2014-11-01

    The effectiveness of a direct quantification assay is essential to the adoption of the combined direct quantification/direct STR workflow. In this paper, the feasibility of using the Quantifiler(®) Trio DNA quantification kit for the direct quantification of forensic casework samples was investigated. Both low-level touch DNA samples and blood samples were collected on PE swabs and quantified directly. The increased sensitivity of the Quantifiler(®) Trio kit enabled the detection of less than 10pg of DNA in unprocessed touch samples and also minimizes the stochastic effect experienced by different targets in the same sample. The DNA quantity information obtained from a direct quantification assay using the Quantifiler(®) Trio kit can also be used to accurately estimate the optimal input DNA quantity for a direct STR amplification reaction. The correlation between the direct quantification results (Quantifiler(®) Trio kit) and the direct STR results (GlobalFiler™ PCR amplification kit(*)) for low-level touch DNA samples indicates that direct quantification using the Quantifiler(®) Trio DNA quantification kit is more reliable than the Quantifiler(®) Duo DNA quantification kit for predicting the STR results of unprocessed touch DNA samples containing less than 10pg of DNA. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  16. [Development and evaluation of a rapid PCR detection kit for Ophiocordyceps sinensis].

    Science.gov (United States)

    Hou, Fei-Xia; Cao, Jing; Wang, Sha-Sha; Wang, Xi; Yuan, Yuan; Peng, Cheng; Wan, De-Guang; Guo, Jin-Lin

    2017-03-01

    Ophiocordyceps sinensis is a valuable traditional Chinese medicine. Due to resource shortage, expensive price and huge market demand, there are many adulterants of O. sinensis in markets. Therefore, it is necessary to establish a rapid and effective method for distinguishing O. sinensis. Based on the species-specific PCR of O. sinensis, this study developed a detection kit by optimizing the components and evaluated the specificity, detection limit, repeatability and shelf life of the kit. The results showed that when the quality of O. sinensis accounted for more than 1/200 of that mixture, it could be detected successfully. Moreover, only O. sinensis could be amplified and glowed bright green fluorescence under ultraviolet light. The kit was still in effect when it was placed at 37 ℃ for three days, which indicated that it was stable and effective for one year stored in 4 ℃. The kit in the same batch under different operation conditions, and in different batch under the same operation conditions gave the same result and accuracy, which showed good repeatability of the kit. It is simple, rapid and accurate to distinguish O. sinensis from its adulterants using the kit, and lays the foundation for commercialization of traditional Chinese medicine fast detection kit. Copyright© by the Chinese Pharmaceutical Association.

  17. [Application of DNA extraction kit, 'GM quicker' for detection of genetically modified soybeans].

    Science.gov (United States)

    Sato, Noriko; Sugiura, Yoshitsugu; Tanaka, Toshitsugu

    2012-01-01

    Several DNA extraction methods have been officially introduced to detect genetically modified soybeans, but the choice of DNA extraction kits depend on the nature of the samples, such as grains or processed foods. To overcome this disadvantage, we examined whether the GM quicker kit is available for both grains and processed foods. We compared GM quicker with four approved DNA extraction kits in respect of DNA purity, copy numbers of lectin gene, and working time. We found that the DNA quality of GM quicker was superior to that of the other kits for grains, and the procedure was faster. However, in the case of processed foods, GM quicker was not superior to the other kits. We therefore investigated an unapproved GM quicker 3 kit, which is available for DNA extraction from processed foods, such as tofu and boiled soybeans. The GM quicker 3 kit provided good DNA quality from both grains and processed foods, so we made a minor modification of the GM quicker-based protocol that was suitable for processed foods, using GM quicker and its reagents. The modified method enhanced the performance of GM quicker with processed foods. We believe that GM quicker with the modified protocol is an excellent tool to obtain high-quality DNA from grains and processed foods for detection of genetically modified soybeans.

  18. Determination of Sn in 99mTc Radiopharmaceutical Kits by Polarographic Methods

    International Nuclear Information System (INIS)

    Castro, M.; Cruz, J.; Sanchez, M.

    2009-01-01

    Kits of 99 m Tc radiopharmaceuticals are used in nuclear medicine for diagnosis of different diseases. Sn (II) is one of the essential components in their formulations, which is used for reduction 99 m Tc-pertechnetate in cold kits for on-site preparation 99 m Tc-pertechnetate radiopharmaceuticals. Usually, these cold kits contain different additives (complexing agents, antioxidants, buffers, etc.) and the amount of Sn (II) varies from kit to kit. The determination of Sn in these products is essential in assessing their quality. We report here the development of a new polarographic method for the determination of Sn (II) and total Sn in representative radiopharmaceuticals kits (for the content of Sn and chemical composition) produced at the Center of Isotopes of Cuba (CENTIS). These methods were validated by analysis of variance and recovery techniques. From the results of the validation, the characteristic functions of uncertainties and fits are considered for the established methods, which give the necessary evidences to demonstrate the usefulness of these methods according to the current trends in Analytical Chemistry. This work provides practical results of great importance for CENTIS. After the speciation of Sn in the MAG3 radiopharmaceuticals kit is inferred that the production process is affected by uncontrolled factors that influence in the product stability, which demonstrates the necessity for analytical tools for the characterization of products and processes. (Author) 57 refs.

  19. Investigation of block foundations resting on soil–rock and rock–rock media under coupled vibrations

    Directory of Open Access Journals (Sweden)

    Renuka Darshyamkar

    2017-04-01

    Full Text Available In the present study, the dynamic response of block foundations of different equivalent radius to mass (Ro/m ratios under coupled vibrations is investigated for various homogeneous and layered systems. The frequency-dependent stiffness and damping of foundation resting on homogeneous soils and rocks are determined using the half-space theory. The dynamic response characteristics of foundation resting on the layered system considering rock–rock combination are evaluated using finite element program with transmitting boundaries. Frequencies versus amplitude responses of block foundation are obtained for both translational and rotational motion. A new methodology is proposed for determination of dynamic response of block foundations resting on soil–rock and weathered rock–rock system in the form of equations and graphs. The variations of dimensionless natural frequency and dimensionless resonant amplitude with shear wave velocity ratio are investigated for different thicknesses of top soil/weathered rock layer. The dynamic behaviors of block foundations are also analyzed for different rock–rock systems by considering sandstone, shale and limestone underlain by basalt. The variations of stiffness, damping and amplitudes of block foundations with frequency are shown in this study for various rock–rock combinations. In the analysis, two resonant peaks are observed at two different frequencies for both translational and rotational motion. It is observed that the dimensionless resonant amplitudes decrease and natural frequencies increase with increase in shear wave velocity ratio. Finally, the parametric study is performed for block foundations with dimensions of 4 m × 3 m × 2 m and 8 m × 5 m × 2 m by using generalized graphs. The variations of natural frequency and peak displacement amplitude are also studied for different top layer thicknesses and eccentric moments.

  20. Uranium endowments in phosphate rock

    International Nuclear Information System (INIS)

    Ulrich, Andrea E.; Schnug, Ewald; Prasser, Horst-Michael; Frossard, Emmanuel

    2014-01-01

    This study seeks to identify and specify the components that make up the prospects of U recovery from phosphate rock. A systems approach is taken. The assessment includes i) reviewing past recovery experience and lessons learned; ii) identifying factors that determine recovery; and iii) establishing a contemporary evaluation of U endowments in phosphate rock reserves, as well as the available and recoverable amounts from phosphate rock and phosphoric acid production. We find that in the past, recovery did not fulfill its potential and that the breakup of the Soviet Union worsened then-favorable recovery market conditions in the 1990s. We find that an estimated 5.7 million tU may be recoverable from phosphate rock reserves. In 2010, the recoverable tU from phosphate rock and phosphoric acid production may have been 15,000 tU and 11,000 tU, respectively. This could have filled the world U supply-demand gap for nuclear energy production. The results suggest that the U.S., Morocco, Tunisia, and Russia would be particularly well-suited to recover U, taking infrastructural considerations into account. We demonstrate future research needs, as well as sustainability orientations. We conclude that in order to promote investment and production, it seems necessary to establish long-term contracts at guaranteed prices, ensuring profitability for phosphoric acid producers. - Highlights: • We identify components that underlie the recovery of uranium from phosphate rock. • We estimate that 11,000 tU may have been recoverable from phosphoric acid in 2010. • Recovery is a resource conservation and environmental pollution control strategy. • To ensure investment in recovery technology, profitability needs to be secured

  1. Uranium deposits in granitic rocks

    International Nuclear Information System (INIS)

    Nishimori, R.K.; Ragland, P.C.; Rogers, J.J.W.; Greenberg, J.K.

    1977-01-01

    This report is a review of published data bearing on the geology and origin of uranium deposits in granitic, pegmatitic and migmatitic rocks with the aim of assisting in the development of predictive criteria for the search for similar deposits in the U.S. Efforts were concentrated on the so-called ''porphyry'' uranium deposits. Two types of uranium deposits are primarily considered: deposits in pegmatites and alaskites in gneiss terrains, and disseminations of uranium in high-level granites. In Chapter 1 of this report, the general data on the distribution of uranium in igneous and metamorphic rocks are reviewed. Chapter 2 contains some comments on the classification of uranium deposits associated with igneous rocks and a summary of the main features of the geology of uranium deposits in granites. General concepts of the behavior of uranium in granites during crustal evolution are reviewed in Chapter 3. Also included is a discussion of the relationship of uranium mineralization in granites to the general evolution of mobile belts, plus the influence of magmatic and post-magmatic processes on the distribution of uranium in igneous rocks and related ore deposits. Chapter 4 relates the results of experimental studies on the crystallization of granites to some of the geologic features of uranium deposits in pegmatites and alaskites in high-grade metamorphic terrains. Potential or favorable areas for igneous uranium deposits in the U.S.A. are delineated in Chapter 5. Data on the geology of specific uranium deposits in granitic rocks are contained in Appendix 1. A compilation of igneous rock formations containing greater than 10 ppM uranium is included in Appendix 2. Appendix 3 is a report on the results of a visit to the Roessing area. Appendix 4 is a report on a field excursion to eastern Canada

  2. Uranium endowments in phosphate rock

    Energy Technology Data Exchange (ETDEWEB)

    Ulrich, Andrea E., E-mail: andrea.ulrich@env.ethz.ch [Institute for Environmental Decisions (IED), Natural and Social Science Interface, ETH Zurich Universitässtrasse 22, 8092 Zurich (Switzerland); Institute for Agricultural Sciences, Plant Nutrition, ETH Zurich, Eschikon 33, 8315 Lindau (Switzerland); Schnug, Ewald, E-mail: e.schnug@tu-braunschweig.de [Department of Life Sciences, Technical University of Braunschweig, Pockelsstraße 14, D-38106 Braunschweig (Germany); Prasser, Horst-Michael, E-mail: prasser@lke.mavt.ethz.ch [Institute of Energy Technology, Laboratory of Nuclear Energy Systems, ETH Zurich, Sonneggstrasse 3, 8092 Zurich (Switzerland); Frossard, Emmanuel, E-mail: emmanuel.frossard@usys.ethz.ch [Institute for Agricultural Sciences, Plant Nutrition, ETH Zurich, Eschikon 33, 8315 Lindau (Switzerland)

    2014-04-01

    This study seeks to identify and specify the components that make up the prospects of U recovery from phosphate rock. A systems approach is taken. The assessment includes i) reviewing past recovery experience and lessons learned; ii) identifying factors that determine recovery; and iii) establishing a contemporary evaluation of U endowments in phosphate rock reserves, as well as the available and recoverable amounts from phosphate rock and phosphoric acid production. We find that in the past, recovery did not fulfill its potential and that the breakup of the Soviet Union worsened then-favorable recovery market conditions in the 1990s. We find that an estimated 5.7 million tU may be recoverable from phosphate rock reserves. In 2010, the recoverable tU from phosphate rock and phosphoric acid production may have been 15,000 tU and 11,000 tU, respectively. This could have filled the world U supply-demand gap for nuclear energy production. The results suggest that the U.S., Morocco, Tunisia, and Russia would be particularly well-suited to recover U, taking infrastructural considerations into account. We demonstrate future research needs, as well as sustainability orientations. We conclude that in order to promote investment and production, it seems necessary to establish long-term contracts at guaranteed prices, ensuring profitability for phosphoric acid producers. - Highlights: • We identify components that underlie the recovery of uranium from phosphate rock. • We estimate that 11,000 tU may have been recoverable from phosphoric acid in 2010. • Recovery is a resource conservation and environmental pollution control strategy. • To ensure investment in recovery technology, profitability needs to be secured.

  3. THM-coupled modeling of selected processes in argillaceous rock relevant to rock mechanics; THM-Gekoppelte Modellierung ausgewaehlter gesteinsmechanisch relevanter Prozesse im Tongestein

    Energy Technology Data Exchange (ETDEWEB)

    Czaikowski, Oliver [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, Braunschweig (Germany). Repository Safety Research Div.

    2012-08-15

    Scientific investigations in European countries other than Germany concentrate not only on granite formations (Switzerland, Sweden) but also on argillaceous rock formations (France, Switzerland, Belgium) to assess their suitability as host and barrier rock for the final storage of radioactive waste. In Germany, rock salt has been under thorough study as a host rock over the past few decades. According to a study by the German Federal Institute for Geosciences and Natural Resources, however, not only salt deposits but also argillaceous rock deposits are available at relevant depths and of extensions in space which make final storage of high-level radioactive waste basically possible in Germany. Equally qualified findings about the suitability/unsuitability of non-saline rock formations require fundamental studies to be conducted nationally because of the comparatively low level of knowledge. The article presents basic analyses of coupled mechanical and hydraulic properties of argillaceous rock formations as host rock for a repository. The interaction of various processes is explained on the basis of knowledge derived from laboratory studies, and open problems are deduced. For modeling coupled processes, a simplified analytical computation method is proposed and compared with the results of numerical simulations, and the limits to its application are outlined. (orig.)

  4. A New Method to Stabilize c-kit Expression in Reparative Cardiac Mesenchymal Cells

    Directory of Open Access Journals (Sweden)

    Marcin Wysoczynski

    2016-08-01

    Full Text Available Cell therapy improves cardiac function. Few cells have been investigated more extensively or consistently shown to be more effective than c-kit sorted cells; however, c-kit expression is easily lost during passage. Here, our primary goal was to develop an improved method to isolate c-kitpos cells and maintain c-kit expression after passaging. Cardiac mesenchymal cells (CMCs from wild-type mice were selected by polystyrene adherence properties. CMCs adhering within the first hours are referred to as rapidly adherent (RA; CMCs adhering subsequently are dubbed slowly adherent (SA. Both RA and SA CMCs were c-kit sorted. SA CMCs maintained significantly higher c-kit expression than RA cells; SA CMCs also had higher expression endothelial markers. We subsequently tested the relative efficacy of SA versus RA CMCs in the setting of post-infarct adoptive transfer. Two days after coronary occlusion, vehicle, RA CMCs, or SA CMCs were delivered percutaneously with echocardiographic guidance. SA CMCs, but not RA CMCs, significantly improved cardiac function compared to vehicle treatment. Although the mechanism remains to be elucidated, the more pronounced endothelial phenotype of the SA CMCs coupled with the finding of increased vascular density suggest a potential pro-vasculogenic action. This new method of isolating CMCs better preserves c-kit expression during passage. SA CMCs, but not RA CMCs, were effective in reducing cardiac dysfunction. Although c-kit expression was maintained, it is unclear whether maintenance of c-kit expression per se was responsible for improved function, or whether the differential adherence property itself confers a reparative phenotype independently of c-kit.

  5. Evaluation of three high abundance protein depletion kits for umbilical cord serum proteomics

    Directory of Open Access Journals (Sweden)

    Nie Jing

    2011-05-01

    Full Text Available Abstract Background High abundance protein depletion is a major challenge in the study of serum/plasma proteomics. Prior to this study, most commercially available kits for depletion of highly abundant proteins had only been tested and evaluated in adult serum/plasma, while the depletion efficiency on umbilical cord serum/plasma had not been clarified. Structural differences between some adult and fetal proteins (such as albumin make it likely that depletion approaches for adult and umbilical cord serum/plasma will be variable. Therefore, the primary purposes of the present study are to investigate the efficiencies of several commonly-used commercial kits during high abundance protein depletion from umbilical cord serum and to determine which kit yields the most effective and reproducible results for further proteomics research on umbilical cord serum. Results The immunoaffinity based kits (PROTIA-Sigma and 5185-Agilent displayed higher depletion efficiency than the immobilized dye based kit (PROTBA-Sigma in umbilical cord serum samples. Both the PROTIA-Sigma and 5185-Agilent kit maintained high depletion efficiency when used three consecutive times. Depletion by the PROTIA-Sigma Kit improved 2DE gel quality by reducing smeared bands produced by the presence of high abundance proteins and increasing the intensity of other protein spots. During image analysis using the identical detection parameters, 411 ± 18 spots were detected in crude serum gels, while 757 ± 43 spots were detected in depleted serum gels. Eight spots unique to depleted serum gels were identified by MALDI- TOF/TOF MS, seven of which were low abundance proteins. Conclusions The immunoaffinity based kits exceeded the immobilized dye based kit in high abundance protein depletion of umbilical cord serum samples and dramatically improved 2DE gel quality for detection of trace biomarkers.

  6. Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

    Science.gov (United States)

    Roskoski, Robert

    2005-11-11

    Signaling by stem cell factor and Kit, its receptor, plays important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human and mouse embryonic stem cells express Kit transcripts. Stem cell factor exists as both a soluble and a membrane-bound glycoprotein while Kit is a receptor protein-tyrosine kinase. The complete absence of stem cell factor or Kit is lethal. Deficiencies of either produce defects in red and white blood cell production, hypopigmentation, and sterility. Gain-of-function mutations of Kit are associated with several human neoplasms including acute myelogenous leukemia, gastrointestinal stromal tumors, and mastocytomas. Kit consists of an extracellular domain, a transmembrane segment, a juxtamembrane segment, and a protein kinase domain that contains an insert of about 80 amino acid residues. Binding of stem cell factor to Kit results in receptor dimerization and activation of protein kinase activity. The activated receptor becomes autophosphorylated at tyrosine residues that serve as docking sites for signal transduction molecules containing SH2 domains. The adaptor protein APS, Src family kinases, and Shp2 tyrosyl phosphatase bind to phosphotyrosine 568. Shp1 tyrosyl phosphatase and the adaptor protein Shc bind to phosphotyrosine 570. C-terminal Src kinase homologous kinase and the adaptor Shc bind to both phosphotyrosines 568 and 570. These residues occur in the juxtamembrane segment of Kit. Three residues in the kinase insert domain are phosphorylated and attract the adaptor protein Grb2 (Tyr703), phosphatidylinositol 3-kinase (Tyr721), and phospholipase Cgamma (Tyr730). Phosphotyrosine 900 in the distal kinase domain binds phosphatidylinositol 3-kinase which in turn binds the adaptor protein Crk. Phosphotyrosine 936, also in the distal kinase domain, binds the adaptor proteins APS, Grb2, and Grb7. Kit has the potential to participate in multiple signal transduction pathways as a result of

  7. Investigation and hazard assessment of the 2003 and 2007 Staircase Falls rock falls, Yosemite National Park, California, USA

    Directory of Open Access Journals (Sweden)

    G. F. Wieczorek

    2008-05-01

    Full Text Available Since 1857 more than 600 rock falls, rock slides, debris slides, and debris flows have been documented in Yosemite National Park, with rock falls in Yosemite Valley representing the majority of the events. On 26 December 2003, a rock fall originating from west of Glacier Point sent approximately 200 m3 of rock debris down a series of joint-controlled ledges to the floor of Yosemite Valley. The debris impacted talus near the base of Staircase Falls, producing fragments of flying rock that struck occupied cabins in Curry Village. Several years later on 9 June 2007, and again on 26 July 2007, smaller rock falls originated from the same source area. The 26 December 2003 event coincided with a severe winter storm and was likely triggered by precipitation and/or frost wedging, but the 9 June and 26 July 2007 events lack recognizable triggering mechanisms. We investigated the geologic and hydrologic factors contributing to the Staircase Falls rock falls, including bedrock lithology, weathering, joint spacing and orientations, and hydrologic processes affecting slope stability. We improved upon previous geomorphic assessment of rock-fall hazards, based on a shadow angle approach, by using STONE, a three-dimensional rock-fall simulation computer program. STONE produced simulated rock-fall runout patterns similar to the mapped extent of the 2003 and 2007 events, allowing us to simulate potential future rock falls from the Staircase Falls detachment area. Observations of recent rock falls, mapping of rock debris, and simulations of rock fall runouts beneath the Staircase Falls detachment area suggest that rock-fall hazard zones extend farther downslope than the extent previously defined by mapped surface talus deposits.

  8. Investigation and hazard assessment of the 2003 and 2007 Staircase Falls rock falls, Yosemite National Park, California, USA

    Science.gov (United States)

    Wieczorek, G. F.; Stock, G. M.; Reichenbach, P.; Snyder, J. B.; Borchers, J. W.; Godt, J. W.

    2008-05-01

    Since 1857 more than 600 rock falls, rock slides, debris slides, and debris flows have been documented in Yosemite National Park, with rock falls in Yosemite Valley representing the majority of the events. On 26 December 2003, a rock fall originating from west of Glacier Point sent approximately 200 m3 of rock debris down a series of joint-controlled ledges to the floor of Yosemite Valley. The debris impacted talus near the base of Staircase Falls, producing fragments of flying rock that struck occupied cabins in Curry Village. Several years later on 9 June 2007, and again on 26 July 2007, smaller rock falls originated from the same source area. The 26 December 2003 event coincided with a severe winter storm and was likely triggered by precipitation and/or frost wedging, but the 9 June and 26 July 2007 events lack recognizable triggering mechanisms. We investigated the geologic and hydrologic factors contributing to the Staircase Falls rock falls, including bedrock lithology, weathering, joint spacing and orientations, and hydrologic processes affecting slope stability. We improved upon previous geomorphic assessment of rock-fall hazards, based on a shadow angle approach, by using STONE, a three-dimensional rock-fall simulation computer program. STONE produced simulated rock-fall runout patterns similar to the mapped extent of the 2003 and 2007 events, allowing us to simulate potential future rock falls from the Staircase Falls detachment area. Observations of recent rock falls, mapping of rock debris, and simulations of rock fall runouts beneath the Staircase Falls detachment area suggest that rock-fall hazard zones extend farther downslope than the extent previously defined by mapped surface talus deposits.

  9. Evaluation of Rock Joint Coefficients

    Science.gov (United States)

    Audy, Ondřej; Ficker, Tomáš

    2017-10-01

    A computer method for evaluation of rock joint coefficients is described and several applications are presented. The method is based on two absolute numerical indicators that are formed by means of the Fourier replicas of rock joint profiles. The first indicator quantifies the vertical depth of profiles and the second indicator classifies wavy character of profiles. The absolute indicators have replaced the formerly used relative indicators that showed some artificial behavior in some cases. This contribution is focused on practical computations testing the functionality of the newly introduced indicators.

  10. Ultrasonically assisted drilling of rocks

    Science.gov (United States)

    Mikhailova, N. V.; Onawumi, P. Y.; Roy, A.; Silberschmidt, V. V.

    2018-05-01

    Conventional drilling of rocks can generate significant damage in the drilled material; a material layer is often split off a back surface of a sample during drilling, negatively affecting its strength. To improve finish quality, ultrasonically assisted drilling (UAD) was employed in two rocks - sandstone and marble. Damage areas in both materials were reduced in UAD when compared to conventional drilling. Reductions in a thrust force and a torque reduction were observed only for UAD in marble; ultrasonic assistance in sandstone drilling did not result in improvements in this regard.

  11. Rock mechanics studies for SMES

    International Nuclear Information System (INIS)

    Haimson, B.C.

    1981-01-01

    Superconducting magnetic energy storage (SMES) systems capable of storing thousands of MWh develop tremendous magnetically induced forces when charged. To prevent rutpure of the magnets these forces must be confined. Bedrock offers a practical and relatively inexpensive magnet containment structure. This paper examines the need for rock mechanics research in connection with the construction and use of SMES rock caverns; the unique problems related to housing superconducting magnets in bedrock; site investigations of granite, quartzite and dolomite deposits in Wisconsin; and cavern design requirements to assure cavern stability and limited deformation under the expected mechanical leads. Recommendations are made for siting SMES caverns

  12. Source rock potential of middle cretaceous rocks in Southwestern Montana

    Science.gov (United States)

    Dyman, T.S.; Palacas, J.G.; Tysdal, R.G.; Perry, W.J.; Pawlewicz, M.J.

    1996-01-01

    The middle Cretaceous in southwestern Montana is composed of a marine and nonmarine succession of predominantly clastic rocks that were deposited along the western margin of the Western Interior Seaway. In places, middle Cretaceous rocks contain appreciable total organic carbon (TOC), such as 5.59% for the Mowry Shale and 8.11% for the Frontier Formation in the Madison Range. Most samples, however, exhibit less than 1.0% TOC. The genetic or hydrocarbon potential (S1+S2) of all the samples analyzed, except one, yield less than 1 mg HC/g rock, strongly indicating poor potential for generating commercial amounts of hydrocarbons. Out of 51 samples analyzed, only one (a Thermopolis Shale sample from the Snowcrest Range) showed a moderate petroleum potential of 3.1 mg HC/g rock. Most of the middle Cretaceous samples are thermally immature to marginally mature, with vitrinite reflectance ranging from about 0.4 to 0.6% Ro. Maturity is high in the Pioneer Mountains, where vitrinite reflectance averages 3.4% Ro, and at Big Sky Montana, where vitrinite reflectance averages 2.5% Ro. At both localities, high Ro values are due to local heat sources, such as the Pioneer batholith in the Pioneer Mountains.

  13. Sealing of rock fractures

    International Nuclear Information System (INIS)

    Pusch, R.; Erlstroem, M.; Boergesson, L.

    1985-12-01

    The major water-bearing fractures in granite usually from fairly regular sets but the extension and degree of connectivity is varying. This means that only a few fractures that are interconnected with the deposition holes and larger water-bearing structures in a HLW repository are expected and if they can be identified and cut off through sealing it would be possible to improve the isolation of waste packages very effectively. Nature's own fracture sealing mechanisms may be simulated and a survey of the involved processes actually suggests a number of possible filling methods and substances. Most of them require high temperature and pressure and correspondingly sophisticated techniques, but some are of potential interest for immediate application with rather moderate effort. Such a technique is to fill the fractures with clayey substances which stay flexible and low-permeable provided that they remain physically and chemically intact. It is demonstrated in the report that effective grouting requires a very low viscosity and shear strength of the substance and this can be achieved by mechanical agitation as demonstrated in this report. Thus, by superimposing static pressure and shear waves induced by percussion hammering at a suitable frequency, clays and fine-grained silts as well as cement can be driven into fractures with an average aperture as small as 0.1 mm. Experiments were made in the laboratory using concrete and steel plates, and a field pilot test was also conducted under realistic conditions on site in Stripa. They all demonstrated the practicality of the 'dynamic injection technique' and that the fluid condition of the grouts yielded complete filling of the injected space to a considerable distance from the injection point. The field test indicated a good sealing ability as well as a surprisingly high resistance to erosion and piping. (author)

  14. Soft Rock Yields Clues to Mars' Past

    Science.gov (United States)

    2004-01-01

    [figure removed for brevity, see original site] Figure 1 This image taken by the Mars Exploration Rover Spirit shows the rock outcrop dubbed 'Clovis.' The rock was discovered to be softer than other rocks studied so far at Gusev Crater after the rover easily ground a hole into it with its rock abrasion tool. Spirit's solar panels can be seen in the foreground. This image was taken by the rover's navigation camera on sol 205 (July 31, 2004). Elemental Trio Found in 'Clovis' Figure 1 above shows that the interior of the rock dubbed 'Clovis' contains higher concentrations of sulfur, bromine and chlorine than basaltic, or volcanic, rocks studied so far at Gusev Crater. The data were taken by the Mars Exploration Rover Spirit's alpha particle X-ray spectrometer after the rover dug into Clovis with its rock abrasion tool. The findings might indicate that this rock was chemically altered, and that fluids once flowed through the rock depositing these elements.

  15. A critical appraisal of a further three new commercial digoxin radioimmunoassay kits with reference to cross-reacting substances

    International Nuclear Information System (INIS)

    Wood, W.G.; Wachter, C.

    1979-01-01

    A further 3 digoxin radioimmunoassay (RIA) kits have been evaluated for performance and cross-reaction with digitoxin, spironolactone, canrenone and furosemide (Lasix-Hoechst). Effects of serum protein concentrations have also been tested. The kits tested were from the following manufacturers: A) Diagnostic Products Corporation Digoxin RIA Kit. B) Byk-Mallinckrodt SPAC Digoxin Kit. C) Boehringer-Mannheim Digoxin RIA Kit. All kits used a 125 I-labelled tracer. Kit A used a conventional liquid phase system using double-antibody separation for bound and free drug. Kits B and C used a solid-phase antibody coated tube method. All kits showed a lower cross-reaction to digitoxin than quoted by the manufacturer. Cross-reaction to spironolactone (Aldactone - Boehringer-Mannheim) was less than 1.50 nmol/l at a serum concentration of 125 mg/l Aldactone in all 3 kits. The cross-reaction to canrenone was somewhat higher, 5.2 nmol/l 'digoxin' being measured in one kit at a serum canrenone concentration of 125 mg/l. There was no cross-reaction with furosemide in any kit, even at a serum concentration of 5 g/l. The coated-tube assays were affected by serum albumin and globulin concentration changes, one kit showing a difference of over 50% binding in the range 1-20% albumin. The double-antibody kit did not show dependence on the concentration of these proteins. All kits measured digoxin with good reproducibility in the range 0.40-10.0 nmol/l. (orig.) [de

  16. Fundamental and clinical evaluation of vasoactive intestinal peptide (VIP) in pancreatitis by radioimmunoassay kit

    International Nuclear Information System (INIS)

    Uehara, Soichiro; Nakamura, Takayuki; Ihara, Kenichi; Isogawa, Shin; Hirayama, Akio

    1987-01-01

    Plasma vasoactive intestinal peptide (VIP) concentrations of normal individuals and patients with pancreatitis were studied using a VIP RIA kit. The inter-assay and intra-assay variation of this kit were between 2.1 and 9.4 %. The VIP levels increased in the acute phase of acute pancreatitis and patients with chronic pancreatitis. The VIP concentration increased during the first 30 min of glucose tolerance test, but this increase was much smaller than that in insulin. These results suggest that this kit is useful for physiologic and pathologic changes in the VIP level. (author)

  17. Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes

    DEFF Research Database (Denmark)

    Rajpert-De Meyts, Ewa; Jørgensen, N; Müller, Jørn

    1996-01-01

    conditions which included 45,X/46,XY mosaicism; androgen insensitivity syndrome; and 46,XY/iso(p)Y mosaicism. Individuals with such disorders of sexual differentiation and Y-chromosome material carry a very high risk of developing testicular neoplasms. Fetal testicular germ cells of the intersex subjects...... expressed Kit at a later developmental age than controls, in which no Kit protein was detectable beyond the 15th week of gestation. This finding may indicate a disturbance of the chronology of germ cell development, or it may suggest a change of the regulation of c-kit expression in subjects with disorders...

  18. iOS Game Development using SpriteKit Framework with Swift Programming Language

    OpenAIRE

    Gurung, Lal

    2016-01-01

    iOS is a mobile operating system for Apple manufactured phones and tablets. Mobile Gaming Industries are growing very fast, and compatibility with iOS is becoming very popular among game developers. The aim of this Bachelor’s thesis was to find the best available game development tools for iOS platform. The 2D game named Lapland was developed using Apple’s own native framework, SpriteKit. The game was written with the SpriteKit programming language. The combination of SpriteKit and Swift...

  19. Sup(99m)Tc(Sn)-sucralfate; development of an instant labelling kit

    International Nuclear Information System (INIS)

    Grouls, R.J.E.; Ackerman, E.W.; Weegh, G. op de

    1988-01-01

    An instant labelling kit for the preparation of 99m Tc(Sn)-sucralfate has been developed containing 500 mg sucralfate and 1 mg SnCl 2 · 2 H 2 O. The labelling yield, in vitro stability and biodistribution indicate (bio)equivalence of 99m Tc(Sn)-sucralfate and 99m Tc(HSA)-sucralfate. The percentages of labelling obtained with the kit during a period of 8 months always exceeded 95%. The preparation kit is inexpensive and the labelling procedure fast and easy. (author)

  20. Use of monoclonal immunoradiometric assays for sensitive TSH measurements: evaluation of four commercially obtainable kits

    International Nuclear Information System (INIS)

    Smitz, J.; Schiettecatte, J.; Stierteghem, A.C. van; Jonckheer, M.H.

    1987-01-01

    Four commerically available monoclonal immunoradiometric methods for the assay of TSH are tested. These four kits are: RIA-GNOST TSH code 0CPL of Behring, SUCROSEP TSH IRMA of Boots, TSH-IRMA-CT-100 of Medgenix, TSH-RIA bead II Ultrasensitive of Abbott. The accuracy, sensitivity and reproducibility of the four kits are compared. The methods are also clinically evaluated. The authors concluded that the kits of Abbott, Behring and Boots are suitable for use in the routine laboratory. 4 refs.; 4 figs.; 7 tabs