WorldWideScience

Sample records for sources previous studies

  1. Repeat immigration: A previously unobserved source of heterogeneity?

    Science.gov (United States)

    Aradhya, Siddartha; Scott, Kirk; Smith, Christopher D

    2017-07-01

    Register data allow for nuanced analyses of heterogeneities between sub-groups which are not observable in other data sources. One heterogeneity for which register data is particularly useful is in identifying unique migration histories of immigrant populations, a group of interest across disciplines. Years since migration is a commonly used measure of integration in studies seeking to understand the outcomes of immigrants. This study constructs detailed migration histories to test whether misclassified migrations may mask important heterogeneities. In doing so, we identify a previously understudied group of migrants called repeat immigrants, and show that they differ systematically from permanent immigrants. In addition, we quantify the degree to which migration information is misreported in the registers. The analysis is carried out in two steps. First, we estimate income trajectories for repeat immigrants and permanent immigrants to understand the degree to which they differ. Second, we test data validity by cross-referencing migration information with changes in income to determine whether there are inconsistencies indicating misreporting. From the first part of the analysis, the results indicate that repeat immigrants systematically differ from permanent immigrants in terms of income trajectories. Furthermore, income trajectories differ based on the way in which years since migration is calculated. The second part of the analysis suggests that misreported migration events, while present, are negligible. Repeat immigrants differ in terms of income trajectories, and may differ in terms of other outcomes as well. Furthermore, this study underlines that Swedish registers provide a reliable data source to analyze groups which are unidentifiable in other data sources.

  2. On the Tengiz petroleum deposit previous study

    International Nuclear Information System (INIS)

    Nysangaliev, A.N.; Kuspangaliev, T.K.

    1997-01-01

    Tengiz petroleum deposit previous study is described. Some consideration about structure of productive formation, specific characteristic properties of petroleum-bearing collectors are presented. Recommendation on their detail study and using of experience on exploration and development of petroleum deposit which have analogy on most important geological and industrial parameters are given. (author)

  3. Review of previous geophysical and geological studies

    Digital Repository Service at National Institute of Oceanography (India)

    Levchenko, O.V.; Neprochnov, Y.P; Rao, D.G; Subrahmanyam, C.; Murthy, K.S

    stream_size 5 stream_content_type text/plain stream_name Mem_Geol_Soc_India_39_5.pdf.txt stream_source_info Mem_Geol_Soc_India_39_5.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  4. Personality disorders in previously detained adolescent females: a prospective study

    NARCIS (Netherlands)

    Krabbendam, A.; Colins, O.F.; Doreleijers, T.A.H.; van der Molen, E.; Beekman, A.T.F.; Vermeiren, R.R.J.M.

    2015-01-01

    This longitudinal study investigated the predictive value of trauma and mental health problems for the development of antisocial personality disorder (ASPD) and borderline personality disorder (BPD) in previously detained women. The participants were 229 detained adolescent females who were assessed

  5. Using an epiphytic moss to identify previously unknown sources of atmospheric cadmium pollution

    Science.gov (United States)

    Geoffrey H. Donovan; Sarah E. Jovan; Demetrios Gatziolis; Igor Burstyn; Yvonne L. Michael; Michael C. Amacher; Vicente J. Monleon

    2016-01-01

    Urban networks of air-quality monitors are often too widely spaced to identify sources of air pollutants, especially if they do not disperse far from emission sources. The objectives of this study were to test the use of moss bio-indicators to develop a fine-scale map of atmospherically-derived cadmium and to identify the sources of cadmium in a complex urban setting....

  6. Radon anomalies prior to earthquakes (1). Review of previous studies

    International Nuclear Information System (INIS)

    Ishikawa, Tetsuo; Tokonami, Shinji; Yasuoka, Yumi; Shinogi, Masaki; Nagahama, Hiroyuki; Omori, Yasutaka; Kawada, Yusuke

    2008-01-01

    The relationship between radon anomalies and earthquakes has been studied for more than 30 years. However, most of the studies dealt with radon in soil gas or in groundwater. Before the 1995 Hyogoken-Nanbu earthquake, an anomalous increase of atmospheric radon was observed at Kobe Pharmaceutical University. The increase was well fitted with a mathematical model related to earthquake fault dynamics. This paper reports the significance of this observation, reviewing previous studies on radon anomaly before earthquakes. Groundwater/soil radon measurements for earthquake prediction began in 1970's in Japan as well as foreign countries. One of the most famous studies in Japan is groundwater radon anomaly before the 1978 Izu-Oshima-kinkai earthquake. We have recognized the significance of radon in earthquake prediction research, but recently its limitation was also pointed out. Some researchers are looking for a better indicator for precursors; simultaneous measurements of radon and other gases are new trials in recent studies. Contrary to soil/groundwater radon, we have not paid much attention to atmospheric radon before earthquakes. However, it might be possible to detect precursors in atmospheric radon before a large earthquake. In the next issues, we will discuss the details of the anomalous atmospheric radon data observed before the Hyogoken-Nanbu earthquake. (author)

  7. Using an epiphytic moss to identify previously unknown sources of atmospheric cadmium pollution.

    Science.gov (United States)

    Donovan, Geoffrey H; Jovan, Sarah E; Gatziolis, Demetrios; Burstyn, Igor; Michael, Yvonne L; Amacher, Michael C; Monleon, Vicente J

    2016-07-15

    Urban networks of air-quality monitors are often too widely spaced to identify sources of air pollutants, especially if they do not disperse far from emission sources. The objectives of this study were to test the use of moss bio-indicators to develop a fine-scale map of atmospherically-derived cadmium and to identify the sources of cadmium in a complex urban setting. We collected 346 samples of the moss Orthotrichum lyellii from deciduous trees in December, 2013 using a modified randomized grid-based sampling strategy across Portland, Oregon. We estimated a spatial linear model of moss cadmium levels and predicted cadmium on a 50m grid across the city. Cadmium levels in moss were positively correlated with proximity to two stained-glass manufacturers, proximity to the Oregon-Washington border, and percent industrial land in a 500m buffer, and negatively correlated with percent residential land in a 500m buffer. The maps showed very high concentrations of cadmium around the two stained-glass manufacturers, neither of which were known to environmental regulators as cadmium emitters. In addition, in response to our findings, the Oregon Department of Environmental Quality placed an instrumental monitor 120m from the larger stained-glass manufacturer in October, 2015. The monthly average atmospheric cadmium concentration was 29.4ng/m(3), which is 49 times higher than Oregon's benchmark of 0.6ng/m(3), and high enough to pose a health risk from even short-term exposure. Both stained-glass manufacturers voluntarily stopped using cadmium after the monitoring results were made public, and the monthly average cadmium levels precipitously dropped to 1.1ng/m(3) for stained-glass manufacturer #1 and 0.67ng/m(3) for stained-glass manufacturer #2. Published by Elsevier B.V.

  8. Using an epiphytic moss to identify previously unknown sources of atmospheric cadmium pollution

    Energy Technology Data Exchange (ETDEWEB)

    Donovan, Geoffrey H., E-mail: gdonovan@fs.fed.us [USDA Forest Service, PNW Research Station, 620 SW Main, Suite 400, Portland, OR 97205 (United States); Jovan, Sarah E., E-mail: sjovan@fs.fed.us [USDA Forest Service, PNW Research Station, 620 SW Main, Suite 400, Portland, OR 97205 (United States); Gatziolis, Demetrios, E-mail: dgatziolis@fs.fed.us [USDA Forest Service, PNW Research Station, 620 SW Main, Suite 400, Portland, OR 97205 (United States); Burstyn, Igor, E-mail: igor.burstyn@drexel.edu [Dornsife School of Public Health, Drexel University, Nesbitt Hall, 3215 Market St, Philadelphia, PA 19104 (United States); Michael, Yvonne L., E-mail: ylm23@drexel.edu [Dornsife School of Public Health, Drexel University, Nesbitt Hall, 3215 Market St, Philadelphia, PA 19104 (United States); Amacher, Michael C., E-mail: mcamacher1@outlook.com [USDA Forest Service, Logan Forest Sciences Laboratory, 860 North 1200 East, Logan, UT 84321 (United States); Monleon, Vicente J., E-mail: vjmonleon@fs.fed.us [USDA Forest Service, PNW Research Station, 3200 SW Jefferson Way, Corvallis, OR 97331 (United States)

    2016-07-15

    Urban networks of air-quality monitors are often too widely spaced to identify sources of air pollutants, especially if they do not disperse far from emission sources. The objectives of this study were to test the use of moss bio-indicators to develop a fine-scale map of atmospherically-derived cadmium and to identify the sources of cadmium in a complex urban setting. We collected 346 samples of the moss Orthotrichum lyellii from deciduous trees in December, 2013 using a modified randomized grid-based sampling strategy across Portland, Oregon. We estimated a spatial linear model of moss cadmium levels and predicted cadmium on a 50 m grid across the city. Cadmium levels in moss were positively correlated with proximity to two stained-glass manufacturers, proximity to the Oregon–Washington border, and percent industrial land in a 500 m buffer, and negatively correlated with percent residential land in a 500 m buffer. The maps showed very high concentrations of cadmium around the two stained-glass manufacturers, neither of which were known to environmental regulators as cadmium emitters. In addition, in response to our findings, the Oregon Department of Environmental Quality placed an instrumental monitor 120 m from the larger stained-glass manufacturer in October, 2015. The monthly average atmospheric cadmium concentration was 29.4 ng/m{sup 3}, which is 49 times higher than Oregon's benchmark of 0.6 ng/m{sup 3}, and high enough to pose a health risk from even short-term exposure. Both stained-glass manufacturers voluntarily stopped using cadmium after the monitoring results were made public, and the monthly average cadmium levels precipitously dropped to 1.1 ng/m{sup 3} for stained-glass manufacturer #1 and 0.67 ng/m{sup 3} for stained-glass manufacturer #2. - Highlights: • Bio-indicators are a valid method for measuring atmospheric pollutants • We used moss to map atmospheric cadmium in Portland, Oregon • Using a spatial linear model, we identified two

  9. Using an epiphytic moss to identify previously unknown sources of atmospheric cadmium pollution

    International Nuclear Information System (INIS)

    Donovan, Geoffrey H.; Jovan, Sarah E.; Gatziolis, Demetrios; Burstyn, Igor; Michael, Yvonne L.; Amacher, Michael C.; Monleon, Vicente J.

    2016-01-01

    Urban networks of air-quality monitors are often too widely spaced to identify sources of air pollutants, especially if they do not disperse far from emission sources. The objectives of this study were to test the use of moss bio-indicators to develop a fine-scale map of atmospherically-derived cadmium and to identify the sources of cadmium in a complex urban setting. We collected 346 samples of the moss Orthotrichum lyellii from deciduous trees in December, 2013 using a modified randomized grid-based sampling strategy across Portland, Oregon. We estimated a spatial linear model of moss cadmium levels and predicted cadmium on a 50 m grid across the city. Cadmium levels in moss were positively correlated with proximity to two stained-glass manufacturers, proximity to the Oregon–Washington border, and percent industrial land in a 500 m buffer, and negatively correlated with percent residential land in a 500 m buffer. The maps showed very high concentrations of cadmium around the two stained-glass manufacturers, neither of which were known to environmental regulators as cadmium emitters. In addition, in response to our findings, the Oregon Department of Environmental Quality placed an instrumental monitor 120 m from the larger stained-glass manufacturer in October, 2015. The monthly average atmospheric cadmium concentration was 29.4 ng/m"3, which is 49 times higher than Oregon's benchmark of 0.6 ng/m"3, and high enough to pose a health risk from even short-term exposure. Both stained-glass manufacturers voluntarily stopped using cadmium after the monitoring results were made public, and the monthly average cadmium levels precipitously dropped to 1.1 ng/m"3 for stained-glass manufacturer #1 and 0.67 ng/m"3 for stained-glass manufacturer #2. - Highlights: • Bio-indicators are a valid method for measuring atmospheric pollutants • We used moss to map atmospheric cadmium in Portland, Oregon • Using a spatial linear model, we identified two stained

  10. Study of some physical aspects previous to design of an exponential experiment

    International Nuclear Information System (INIS)

    Caro, R.; Francisco, J. L. de

    1961-01-01

    This report presents the theoretical study of some physical aspects previous to the design of an exponential facility. The are: Fast and slow flux distribution in the multiplicative medium and in the thermal column, slowing down in the thermal column, geometrical distribution and minimum needed intensity of sources access channels and perturbations produced by possible variations in its position and intensity. (Author) 4 refs

  11. Thermal neutron source study

    International Nuclear Information System (INIS)

    Holden, T.M.

    1983-05-01

    The value of intense neutron beams for condensed matter research is discussed with emphasis on the complementary nature of steady state and pulsed neutron sources. A large body of information on neutron sources, both existing and planned, is then summarized under four major headings: fission reactors, electron accelerators with heavy metal targets, pulsed spallation sources and 'steady state' spallation sources. Although the cost of a spallation source is expected to exceed that of a fission reactor of the same flux by a factor of two, there are significant advantages for a spallation device such as the proposed Electronuclear Materials Test Facility (EMTF)

  12. 40 CFR 152.93 - Citation of a previously submitted valid study.

    Science.gov (United States)

    2010-07-01

    ... Data Submitters' Rights § 152.93 Citation of a previously submitted valid study. An applicant may demonstrate compliance for a data requirement by citing a valid study previously submitted to the Agency. The... the original data submitter, the applicant may cite the study only in accordance with paragraphs (b...

  13. Cold source economic study

    International Nuclear Information System (INIS)

    Fuster, Serge.

    1975-01-01

    This computer code is intended for the statement of the general economic balance resulting from using a given cold source. The balance includes the investments needed for constructing the various materials, and also production balances resulting from their utilization. The case of either using an open circuit condenser on sea or river, or using air cooling systems with closed circuits or as auxiliaries can be dealt with. The program can be used to optimize the characteristics of the various parts of the cold source. The performance of the various materials can be evaluated for a given situation from using very full, precise economic balances, these materials can also be classified according to their possible uses, the outer constraints being taken into account (limits for heat disposal into rivers or seas, water temperature, air temperature). Technical choices whose economic consequences are important have been such clarified [fr

  14. Summary of Previous Chamber or Controlled Anthrax Studies and Recommendations for Possible Additional Studies

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F.; Amidan, Brett G.; Morrow, Jayne B.

    2010-12-29

    This report and an associated Excel file(a) summarizes the investigations and results of previous chamber and controlled studies(b) to characterize the performance of methods for collecting, storing and/or transporting, extracting, and analyzing samples from surfaces contaminated by Bacillus anthracis (BA) or related simulants. This report and the Excel are the joint work of the Pacific Northwest National Laboratory (PNNL) and the National Institute of Standards and Technology (NIST) for the Department of Homeland Security, Science and Technology Directorate. The report was originally released as PNNL-SA-69338, Rev. 0 in November 2009 with limited distribution, but was subsequently cleared for release with unlimited distribution in this Rev. 1. Only minor changes were made to Rev. 0 to yield Rev. 1. A more substantial update (including summarizing data from other studies and more condensed summary tables of data) is underway

  15. Duopigatron ion source studies

    International Nuclear Information System (INIS)

    Bacon, F.M.; Bickes, R.W. Jr.; O'Hagan, J.B.

    1978-07-01

    Ion source performance characteristics consisting of total ion current, ion energy distribution, mass distribution, and ion current density distribution were measured for several models of a duopigatron. Variations on the duopigatron design involved plasma expansion cup material and dimensions, secondary cathode material, and interelectrode spacings. Of the designs tested, the one with a copper and molybdenum secondary cathode and a mild steel plasma expansion cup proved to give the best results. The ion current density distribution was peaked at the center of the plasma expansion cup and fell off to 80 percent of the peak value at the cup wall for a cup 15.2 mm deep. A total ion current of 180 mA consisting of 60 to 70 percent atomic ions was produced with an arc current of 20 A and source pressure of 9.3 Pa. More shallow cups produced a larger beam current and a more sharply peaked ion current density distribution. Typical ion energy distributions were bell-shaped curves with a peak 10 to 20 V below anode potential and with ion energies extending 30 to 40 V on either side of the peak

  16. Matched cohort study of external cephalic version in women with previous cesarean delivery.

    Science.gov (United States)

    Keepanasseril, Anish; Anand, Keerthana; Soundara Raghavan, Subrahmanian

    2017-07-01

    To evaluate the efficacy and safety of external cephalic version (ECV) among women with previous cesarean delivery. A retrospective study was conducted using data for women with previous cesarean delivery and breech presentation who underwent ECV at or after 36 weeks of pregnancy during 2011-2016. For every case, two multiparous women without previous cesarean delivery who underwent ECV and were matched for age and pregnancy duration were included. Characteristics and outcomes were compared between groups. ECV was successful for 32 (84.2%) of 38 women with previous cesarean delivery and 62 (81.6%) in the control group (P=0.728). Multivariate regression analysis confirmed that previous cesarean was not associated with ECV success (odds ratio 1.89, 95% confidence interval 0.19-18.47; P=0.244). Successful vaginal delivery after successful ECV was reported for 19 (59.4%) women in the previous cesarean delivery group and 52 (83.9%) in the control group (P<0.001). No ECV-associated complications occurred in women with previous cesarean delivery. To avoid a repeat cesarean delivery, ECV can be offered to women with breech presentation and previous cesarean delivery who are otherwise eligible for a trial of labor. © 2017 International Federation of Gynecology and Obstetrics.

  17. Sourcing of internal auditing : An empirical study

    NARCIS (Netherlands)

    Speklé, R.F.; Elten, van H.J.; Kruis, A.

    2007-01-01

    This paper studies the factors associated with organizations’ internal audit sourcing decisions, building from a previous study by Widener and Selto (henceforth W&S) [Widener, S.K., Selto, F.H., 1999. Management control systems and boundaries of the firm: why do firms outsource internal audit

  18. Tire tread wear particles in ambient air--a previously unknown source of human exposure to the biocide 2-mercaptobenzothiazole.

    Science.gov (United States)

    Avagyan, Rozanna; Sadiktsis, Ioannis; Bergvall, Christoffer; Westerholm, Roger

    2014-10-01

    Urban particulate matter (PM), asphalt, and tire samples were investigated for their content of benzothiazole and benzothiazole derivates. The purpose of this study was to examine whether wear particles, i.e., tire tread wear or road surface wear, could contribute to atmospheric concentrations of benzothiazole derivatives. Airborne particulate matter (PM10) sampled at a busy street in Stockholm, Sweden, contained on average 17 pg/m(3) benzothiazole and 64 pg/m(3) 2-mercaptobenzothiazole, and the total suspended particulate-associated benzothiazole and 2-mercaptobenzothiazole concentrations were 199 and 591 pg/m(3), respectively. This indicates that tire tread wear may be a major source of these benzothiazoles to urban air PM in Stockholm. Furthermore, 2-mercaptobenzothiazole was determined in urban air particulates for the first time in this study, and its presence in inhalable PM10 implies that the human exposure to this biocide is underestimated. This calls for a revision of the risk assessments of 2-mercaptobenzothiazole exposure to humans which currently is limited to occupational exposure.

  19. Study of functional-performance deficits in athletes with previous ankle sprains

    Directory of Open Access Journals (Sweden)

    hamid Babaee

    2008-04-01

    Full Text Available Abstract Background: Despite the importance of functional-performance deficits in athletes with history of ankle sprain few, studies have been carried out in this area. The aim of this research was to study relationship between previous ankle sprains and functional-performance deficits in athletes. Materials and methods: The subjects were 40 professional athletes selected through random sampling among volunteer participants in soccer, basketball, volleyball and handball teams of Lorestan province. The subjects were divided into 2 groups: Injured group (athletes with previous ankle sprains and healthy group (athletes without previous ankle sprains. In this descriptive study we used Functional-performance tests (figure 8 hop test and side hop test to determine ankle deficits and limitations. They participated in figure 8 hop test including hopping in 8 shape course with the length of 5 meters and side hop test including 10 side hop repetitions in course with the length of 30 centimeters. Time were recorded via stopwatch. Results: After data gathering and assessing information distributions, Pearson correlation was used to assess relationships, and independent T test to assess differences between variables. Finally the results showed that there is a significant relationship between previous ankle sprains and functional-performance deficits in the athletes. Conclusion: The athletes who had previous ankle sprains indicated functional-performance deficits more than healthy athletes in completion of mentioned functional-performance tests. The functional-performance tests (figure 8 hop test and side hop test are sensitive and suitable to assess and detect functional-performance deficits in athletes. Therefore we can use the figure 8 hop and side hop tests for goals such as prevention, assessment and rehabilitation of ankle sprains without spending too much money and time.

  20. Source and LINAC3 studies

    CERN Document Server

    Bellodi, G

    2017-01-01

    In the framework of the LHC Ion Injector Upgrade pro-gramme (LIU), several activities have been carried out in2016 to improve the ion source and Linac3 performance,with the goal to increase the beam current routinely deliv-ered to LEIR. The extraction region of the GTS-LHC ionsource was upgraded with enlarged vacuum chamber aper-tures and the addition of an einzel lens, yielding highertransmission through the rest of the machine. Also, a seriesof experiments have been performed to study the effects ofdouble frequency mixing on the afterglow performance ofthe source after installation of a Travelling Wave Tube Am-plifier (TWTA) as secondary microwave source at variablefrequency. Measurements have been carried out at a dedi-cated oven test stand for better understanding of the ionsource performance. Finally, several MD sessions werededicated to the study and characterization of the strippingfoils, after evidence of degradation in time was discoveredin the 2015 run.

  1. Data from studies of previous radioactive waste disposal in Massachusetts Bay

    International Nuclear Information System (INIS)

    Curtis, W.R.; Mardis, H.M.

    1984-12-01

    This report presents the results of studies conducted in Massachusetts Bay during 1981 and 1982. Included are data from: (1) a side scan sonar survey of disposal areas in the Bay that was carried out by the National Oceanic and Atmospheric Administration (NOAA) for EPA; (2) Collections of sediment and biota by NOAA for radiochemical analysis by EPA; (3) collections of marketplace seafood samples by the Food and Drug Administration (FDA) for radioanalysis by both FDA and EPA; and (4) a radiological monitoring survey of LLW disposal areas by EPA to determine whether there should be any concern for public health resulting from previous LLW disposals in the Bay

  2. A longitudinal study of plasma insulin and glucagon in women with previous gestational diabetes

    DEFF Research Database (Denmark)

    Damm, P; Kühl, C; Hornnes, P

    1995-01-01

    OBJECTIVE: To investigate whether plasma insulin or glucagon predicts later development of diabetes in women with gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: The subjects studied were 91 women with diet-treated GDM and 33 healthy women. Plasma insulin and glucagon during a 50...... at follow-up (2 had insulin-dependent diabetes mellitus, 13 had non-insulin-dependent diabetes mellitus, and 12 had impaired glucose tolerance). Compared with the control subjects, women with previous GDM had relatively impaired insulin secretion (decreased insulinogenic index and delayed peak insulin...... for subsequent development of overt diabetes (logistic regression analysis). CONCLUSIONS: Women who develop GDM have a relative insulin secretion deficiency, the severity of which is predictive for later development of diabetes. Furthermore, our data indicate that their relatively reduced beta-cell function may...

  3. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

    Directory of Open Access Journals (Sweden)

    Moreno Victor

    2011-08-01

    Full Text Available Abstract Background Colorectal cancer (CRC is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium. Methods CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and 18 selected variants in the mucin gene family. Results None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a P-value ADH1C (OR = 1.63, 95% CI = 1.06-2.50, P-value = 0.02, recessive, rs1800795 in IL6 (OR = 1.62, 95% CI = 1.10-2.37, P-value = 0.01, recessive, rs3803185 in ARL11 (OR = 1.58, 95% CI = 1.17-2.15, P-value = 0.007, codominant, and rs2102302 in GALNTL2 (OR = 1.20, 95% CI = 1.00-1.44, P-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, P-value = 0.01, recessive. In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1

  4. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

    International Nuclear Information System (INIS)

    Abulí, Anna; Morillas, Juan D; Rigau, Joaquim; Latorre, Mercedes; Fernández-Bañares, Fernando; Peña, Elena; Riestra, Sabino; Payá, Artemio; Jover, Rodrigo; Xicola, Rosa M; Llor, Xavier; Fernández-Rozadilla, Ceres; Carvajal-Carmona, Luis; Villanueva, Cristina M; Moreno, Victor; Piqué, Josep M; Carracedo, Angel; Castells, Antoni; Andreu, Montserrat; Ruiz-Ponte, Clara; Castellví-Bel, Sergi; Alonso-Espinaco, Virginia; Muñoz, Jenifer; Gonzalo, Victoria; Bessa, Xavier; González, Dolors; Clofent, Joan; Cubiella, Joaquin

    2011-01-01

    Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase) are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category) and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium. CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and 18 selected variants in the mucin gene family. None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a P-value < 0.05 in EPICOLON stage 1 [rs698 in ADH1C (OR = 1.63, 95% CI = 1.06-2.50, P-value = 0.02, recessive), rs1800795 in IL6 (OR = 1.62, 95% CI = 1.10-2.37, P-value = 0.01, recessive), rs3803185 in ARL11 (OR = 1.58, 95% CI = 1.17-2.15, P-value = 0.007, codominant), and rs2102302 in GALNTL2 (OR = 1.20, 95% CI = 1.00-1.44, P-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, P-value = 0.01, recessive). In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1.12, 95% CI = 1

  5. A study about the interest and previous contact of high school students with Astronomy

    Science.gov (United States)

    Carvalho, C. L.; Zanitti, M. H. R.; Felicidade, B. L.; Gomes, A. D. T.; Dias, E. W.; Coelho, F. O.

    2016-04-01

    The currently problems in Astronomy teaching in Brazilian Basic Education contrast with the space, and the popularity that astronomical themes have in various media in the country. In this work, we present the results of a study about the interest, and previous contact of high school students from a public school in the city of "São João del-Rei"/MG with topics related to Astronomy. The study and the pedagogical intervention were carried out by students of the PIBID/CAPES/UFSJ. The intervention was performed through an oral exposition with the students' participation, followed by the use of the Stellarium program. The results suggest the majority of students surveyed are interested in Astronomy, and have had some contact with the area. However, some inconsistencies in their responses were identified and examined. The implications for research and for Astronomy Education are discussed. We also make some considerations about relationship between the lack of specific knowledge and the misinformation as one possible reason for the little interest of students in various areas of Science.

  6. Fire Risk Scoping Study: Investigation of nuclear power plant fire risk, including previously unaddressed issues

    International Nuclear Information System (INIS)

    Lambright, J.A.; Nowlen, S.P.; Nicolette, V.F.; Bohn, M.P.

    1989-01-01

    An investigation of nuclear power plant fire risk issues raised as a result of the USNRC sponsored Fire Protection Research Program at Sandia National Laboratories has been performed. The specific objectives of this study were (1) to review and requantify fire risk scenarios from four fire probabilistic risk assessments (PRAs) in light of updated data bases made available as a result of USNRC sponsored Fire Protection Research Program and updated computer fire modeling capabilities, (2) to identify potentially significant fire risk issues that have not been previously addressed in a fire risk context and to quantify the potential impact of those identified fire risk issues where possible, and (3) to review current fire regulations and plant implementation practices for relevance to the identified unaddressed fire risk issues. In performance of the fire risk scenario requantifications several important insights were gained. It was found that utilization of a more extensive operational experience base resulted in both fire occurrence frequencies and fire duration times (i.e., time required for fire suppression) increasing significantly over those assumed in the original works. Additionally, some thermal damage threshold limits assumed in the original works were identified as being nonconservative based on more recent experimental data. Finally, application of the COMPBRN III fire growth model resulted in calculation of considerably longer fire damage times than those calculated in the original works using COMPBRN I. 14 refs., 2 figs., 16 tabs

  7. The suitability of XRF analysis for compositional classification of archaeological ceramic fabric: A comparison with a previous NAA study

    International Nuclear Information System (INIS)

    Padilla, R.; Espen, P. van; Torres, P.P. Godo

    2006-01-01

    The main drawbacks of EDXRF techniques, restricting its more frequent use for the specific purpose of compositional analysis of archaeological ceramic fabric, have been the insufficient sensitivity to determine some important elements (like Cr, REE, among others), a somewhat worse precision and the inability to perform standard-less quantitative procedures in the absence of suitable certified reference materials (CRM) for ceramic fabric. This paper presents the advantages of combining two energy dispersive X-ray fluorescence methods for fast and non-destructive analysis of ceramic fabric with increased sensitivity. Selective polarized excitation using secondary targets (EDPXRF) and radioisotope excitation (R-XRF) using a 241 Am source. The analytical performance of the methods was evaluated by analyzing several CRM of sediment type, and the fitness for the purpose of compositional classification was compared with that obtained by using Instrumental Neutron Activation Analysis in a previous study of Cuban aborigine pottery

  8. The suitability of XRF analysis for compositional classification of archaeological ceramic fabric: A comparison with a previous NAA study

    Energy Technology Data Exchange (ETDEWEB)

    Padilla, R. [Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear (CEADEN), Laboratorio de Analisis Quimico, Calle 30 no. 502, Playa, Ciudad Habana (Cuba)]. E-mail: roman.padilla@infomed.sld.cu; Espen, P. van [University of Antwerp (Belgium); Torres, P.P. Godo [Centro de Antropologia, Havana (Cuba)

    2006-02-03

    The main drawbacks of EDXRF techniques, restricting its more frequent use for the specific purpose of compositional analysis of archaeological ceramic fabric, have been the insufficient sensitivity to determine some important elements (like Cr, REE, among others), a somewhat worse precision and the inability to perform standard-less quantitative procedures in the absence of suitable certified reference materials (CRM) for ceramic fabric. This paper presents the advantages of combining two energy dispersive X-ray fluorescence methods for fast and non-destructive analysis of ceramic fabric with increased sensitivity. Selective polarized excitation using secondary targets (EDPXRF) and radioisotope excitation (R-XRF) using a {sup 241}Am source. The analytical performance of the methods was evaluated by analyzing several CRM of sediment type, and the fitness for the purpose of compositional classification was compared with that obtained by using Instrumental Neutron Activation Analysis in a previous study of Cuban aborigine pottery.

  9. Advanced Neutron Source enrichment study

    International Nuclear Information System (INIS)

    Bari, R.A.; Ludewig, H.; Weeks, J.R.

    1996-01-01

    A study has been performed of the impact on performance of using low-enriched uranium (20% 235 U) or medium-enriched uranium (35% 235 U) as an alternative fuel for the Advanced Neutron Source, which was initially designed to use uranium enriched to 93% 235 U. Higher fuel densities and larger volume cores were evaluated at the lower enrichments in terms of impact on neutron flux, safety, safeguards, technical feasibility, and cost. The feasibility of fabricating uranium silicide fuel at increasing material density was specifically addressed by a panel of international experts on research reactor fuels. The most viable alternative designs for the reactor at lower enrichments were identified and discussed. Several sensitivity analyses were performed to gain an understanding of the performance of the reactor at parametric values of power, fuel density, core volume, and enrichment that were interpolations between the boundary values imposed on the study or extrapolations from known technology

  10. The biomechanics of running in athletes with previous hamstring injury: A case-control study.

    Science.gov (United States)

    Daly, C; Persson, U McCarthy; Twycross-Lewis, R; Woledge, R C; Morrissey, D

    2016-04-01

    Hamstring injury is prevalent with persistently high reinjury rates. We aim to inform hamstring rehabilitation by exploring the electromyographic and kinematic characteristics of running in athletes with previous hamstring injury. Nine elite male Gaelic games athletes who had returned to sport after hamstring injury and eight closely matched controls sprinted while lower limb kinematics and muscle activity of the previously injured biceps femoris, bilateral gluteus maximus, lumbar erector spinae, rectus femoris, and external oblique were recorded. Intergroup comparisons of muscle activation ratios and kinematics were performed. Previously injured athletes demonstrated significantly reduced biceps femoris muscle activation ratios with respect to ipsilateral gluteus maximus (maximum difference -12.5%, P = 0.03), ipsilateral erector spinae (maximum difference -12.5%, P = 0.01), ipsilateral external oblique (maximum difference -23%, P = 0.01), and contralateral rectus femoris (maximum difference -22%, P = 0.02) in the late swing phase. We also detected sagittal asymmetry in hip flexion (maximum 8°, P = 0.01), pelvic tilt (maximum 4°, P = 0.02), and medial rotation of the knee (maximum 6°, P = 0.03) effectively putting the hamstrings in a lengthened position just before heel strike. Previous hamstring injury is associated with altered biceps femoris associated muscle activity and potentially injurious kinematics. These deficits should be considered and addressed during rehabilitation. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Rancidity inhibition study in frozen whole mackerel (scomber scombrus by a previous plant extract treatment.

    Directory of Open Access Journals (Sweden)

    Aubourg, Santiago P.

    2005-09-01

    Full Text Available The effect of flaxseeds (Linum usitatissimum on rancidity development in frozen whole mackerel (Scomber scombrus was studied. For it, fresh mackerel were dipped in flaxseeds aqueous extract during 60 min, frozen at –80 ºC during 24 hours and kept frozen (–20 ºC up to 12 months. Sampling was carried out on the initial material and at months 1, 3, 5, 7, 9 and 12 of frozen storage at –20 ºC. A parallel experiment with non treated fish was carried out in the same conditions. Rancidity development was measured by several biochemical indices (free fatty acids, peroxides, conjugated dienes and trienes, secondary oxidation products and lipoxygenase activity and complemented by the sensory analysis (skin, flesh odour, consistency and flesh appearance. As a result of the previous antioxidant treatment, peroxides showed to breakdown faster (pSe ha estudiado el efecto del lino (Linum usitatissimum en el desarrollo de rancidez en caballa entera congelada (Scomber scombrus. Para ello, caballas frescas fueron sumergidas en extractos acuosos de semillas de lino durante 60 min, congeladas a -80 ºC durante 24 h y mantenidas congeladas ( -20 ºC durante 12 meses. Se tomaron muestras del material inicial y tras 1, 3, 5, 7, 9 y 12 meses de congelación a -20 ºC . Un experimento paralelo con pescado no tratado fue llevado acabo en las mismas condiciones. El desarrollo de la rancidez fue medido por varios índices bioquímicos (ácidos grasos libres, peróxidos, dienos y trienos conjugados, productos secundarios de oxidación y actividad lipoxigenasa y completado con análisis sensorial (piel, olor de la carne, consistencia y apariencia de la carne. Como resultado del tratamiento antioxidante, los peróxidos se degradaron más rápidos (p < 0.05 después del mes 7, y por tanto, contenidos mayores (p < 0.05 de dienos y trienos conjugados pudieron ser detectados en el pescado tratado. El tratamiento antioxidante también condujo a un

  12. Study of some physical aspects previous to design of an exponential experiment; Estudio de algunos aspectos fisicos previos al diseno de una experiencia exponencial

    Energy Technology Data Exchange (ETDEWEB)

    Caro, R; Francisco, J L. de

    1961-07-01

    This report presents the theoretical study of some physical aspects previous to the design of an exponential facility. The are: Fast and slow flux distribution in the multiplicative medium and in the thermal column, slowing down in the thermal column, geometrical distribution and minimum needed intensity of sources access channels and perturbations produced by possible variations in its position and intensity. (Author) 4 refs.

  13. Effect of Previous Irradiation on Vascular Thrombosis of Microsurgical Anastomosis: A Preclinical Study in Rats

    Science.gov (United States)

    Gallardo-Calero, Irene; López-Fernández, Alba; Romagosa, Cleofe; Vergés, Ramona; Aguirre-Canyadell, Marius; Soldado, Francisco; Velez, Roberto

    2016-01-01

    Background: The objective of the present investigation was to compare the effect of neoadjuvant irradiation on the microvascular anastomosis in cervical bundle using an experimental model in rats. Methods: One hundred forty male Sprague–Dawley rats were allocated into 4 groups: group I, control, arterial microanastomosis; group II, control, venous microanastomosis; group III, arterial microanastomosis with previous irradiation (20 Gy); and group IV, venous microanastomosis with previous irradiation (20 Gy). Clinical parameters, technical values of anastomosis, patency, and histopathological parameters were evaluated. Results: Irradiated groups (III and IV) and vein anastomosis groups (II and IV) showed significantly increased technical difficulties. Group IV showed significantly reduced patency rates (7/35) when compared with the control group (0/35). Radiotherapy significantly decreased the patency rates of the vein (7/35) when compared with the artery (1/35). Groups III and IV showed significantly reduced number of endothelial cells and also showed the presence of intimal thickening and adventitial fibrosis as compared with the control group. Conclusion: Neoadjuvant radiotherapy reduces the viability of the venous anastomosis in a preclinical rat model with a significant increase in the incidence of vein thrombosis. PMID:27975009

  14. Late preterm birth and previous cesarean section: a population-based cohort study.

    Science.gov (United States)

    Yasseen Iii, Abdool S; Bassil, Kate; Sprague, Ann; Urquia, Marcelo; Maguire, Jonathon L

    2018-02-21

    Late preterm birth (LPB) is increasingly common and associated with higher morbidity and mortality than term birth. Yet, little is known about the influence of previous cesarean section (PCS) and the occurrence of LPB in subsequent pregnancies. We aim to evaluate this association along with the potential mediation by cesarean sections in the current pregnancy. We use population-based birth registry data (2005-2012) to establish a cohort of live born singleton infants born between 34 and 41 gestational weeks to multiparous mothers. PCS was the primary exposure, LPB (34-36 weeks) was the primary outcome, and an unplanned or emergency cesarean section in the current pregnancy was the potential mediator. Associations were quantified using propensity weighted multivariable Poisson regression, and mediating associations were explored using the Baron-Kenny approach. The cohort included 481,531 births, 21,893 (4.5%) were LPB, and 119,983 (24.9%) were predated by at least one PCS. Among mothers with at least one PCS, 6307 (5.26%) were LPB. There was increased risk of LPB among women with at least one PCS (adjusted Relative Risk (aRR): 1.20 (95%CI [1.16, 1.23]). Unplanned or emergency cesarean section in the current pregnancy was identified as a strong mediator to this relationship (mediation ratio = 97%). PCS was associated with higher risk of LPB in subsequent pregnancies. This may be due to an increased risk of subsequent unplanned or emergency preterm cesarean sections. Efforts to minimize index cesarean sections may reduce the risk of LPB in subsequent pregnancies.

  15. Phase III Study of Cabozantinib in Previously Treated Metastatic Castration-Resistant Prostate Cancer: COMET-1.

    Science.gov (United States)

    Smith, Matthew; De Bono, Johann; Sternberg, Cora; Le Moulec, Sylvestre; Oudard, Stéphane; De Giorgi, Ugo; Krainer, Michael; Bergman, Andries; Hoelzer, Wolfgang; De Wit, Ronald; Bögemann, Martin; Saad, Fred; Cruciani, Giorgio; Thiery-Vuillemin, Antoine; Feyerabend, Susan; Miller, Kurt; Houédé, Nadine; Hussain, Syed; Lam, Elaine; Polikoff, Jonathan; Stenzl, Arnulf; Mainwaring, Paul; Ramies, David; Hessel, Colin; Weitzman, Aaron; Fizazi, Karim

    2016-09-01

    Cabozantinib is an inhibitor of kinases, including MET and vascular endothelial growth factor receptors, and has shown activity in men with previously treated metastatic castration-resistant prostate cancer (mCRPC). This blinded phase III trial compared cabozantinib with prednisone in patients with mCRPC. Men with progressive mCRPC after docetaxel and abiraterone and/or enzalutamide were randomly assigned at a two-to-one ratio to cabozantinib 60 mg once per day or prednisone 5 mg twice per day. The primary end point was overall survival (OS). Bone scan response (BSR) at week 12 as assessed by independent review committee was the secondary end point; radiographic progression-free survival (rPFS) and effects on circulating tumor cells (CTCs), bone biomarkers, serum prostate-specific antigen (PSA), and symptomatic skeletal events (SSEs) were exploratory assessments. A total of 1,028 patients were randomly assigned to cabozantinib (n = 682) or prednisone (n = 346). Median OS was 11.0 months with cabozantinib and 9.8 months with prednisone (hazard ratio, 0.90; 95% CI, 0.76 to 1.06; stratified log-rank P = .213). BSR at week 12 favored cabozantinib (42% v 3%; stratified Cochran-Mantel-Haenszel P < .001). rPFS was improved in the cabozantinib group (median, 5.6 v 2.8 months; hazard ratio, 0.48; 95% CI, 0.40 to 0.57; stratified log-rank P < .001). Cabozantinib was associated with improvements in CTC conversion, bone biomarkers, and post-random assignment incidence of SSEs but not PSA outcomes. Grade 3 to 4 adverse events and discontinuations because of adverse events were higher with cabozantinib than with prednisone (71% v 56% and 33% v 12%, respectively). Cabozantinib did not significantly improve OS compared with prednisone in heavily treated patients with mCRPC and progressive disease after docetaxel and abiraterone and/or enzalutamide. Cabozantinib had some activity in improving BSR, rPFS, SSEs, CTC conversions, and bone biomarkers but not PSA outcomes. © 2016 by

  16. Radon diffusion coefficients for soils. Previous studies and their application to uranium-bearing wastes

    International Nuclear Information System (INIS)

    Sasaki, Tomozo; Gunji, Yasuyoshi; Iida, Takao

    2008-01-01

    Radon diffusion in soils has been studied over the years by many researchers. The application of such studies to the evaluation of radiation exposure caused by radon from uranium-bearing wastes disposed in a shallow land site is very important. The present paper surveyed closely relevant studies and elucidated the inherent nature of radon diffusion in terms of the definition of radon diffusion coefficients. Then, basic features of measurement methods for determining radon diffusion coefficients in soils were explained. Furthermore, theoretical aspects of radon diffusion in soils were discussed in terms of microscopic radon diffusion in soils and large-scale radon diffusion through cover soil defects for uranium mill tailings. Finally, in order to apply the radon diffusion studies to uranium-bearing waste disposal in shallow land sites, new challenges were presented: elucidation of radon diffusion in uranium-bearing wastes and cover-soil cracks, and demonstration of the validity of applying only radon diffusion in the evaluation of radiation exposure caused by radon, which would come through Japanese cover soils for uranium-bearing waste disposal. (author)

  17. Interbirth interval and history of previous preeclampsia: a case–control study among multiparous women

    OpenAIRE

    Harutyunyan, Arusyak; Armenian, Haroutune; Petrosyan, Varduhi

    2013-01-01

    Abstract Background Preeclampsia is a disorder with a reported incidence of 2%-8% among all pregnancies, accounting for more than 50,000 deaths worldwide each year. In low- and middle- income countries maternal/perinatal morbidity and mortality associated with preeclampsia are high due to the lack of proper prenatal and hospital care and limited access to neonatal intensive care. The objectives of our study were to determine the association of long in...

  18. A Review of Previous Studies on Information Processing in Career Decision Making among University Students

    OpenAIRE

    池田, 智子; Satoko, Ikeda

    2018-01-01

    This review of the researches of career choice of Japanese university students focused the studies on decision-making theory conducted in Japan. The present review suggested the necessity of examination of the effect of self-efficacy about career information search on the process of career choice. It is also needed to examine the relationship between specific self-efficacy about career information search and career decision-making self-efficacy, moreover, general self-efficacy.

  19. A Comment Upon Previous Studies on 3-D Boundary Layer Transition

    OpenAIRE

    ÇARPINLIOĞLU, Melda Özdinç

    2014-01-01

    The common feature of the experimental studies upon 3-D boundary layer development on swept flat plates cited in the available literature is the application of streamwise and/or spanwise pressure gradients. In fact; presence of the pressure gradients was suggested to be vital for having crossflow effective in 3-D boundary layer transition. In the presented paper here, this idea is questioned evaluating the results of an experimental investigation conducted on swept flat plates under the ab...

  20. Neuropsychiatric and cardiometabolic comorbidities in patients with previously diagnosed Cushing's disease: a longitudinal observational study

    OpenAIRE

    Dimopoulou, C; Geraedts, V; Stalla, G K; Sievers, C

    2015-01-01

    INTRODUCTION: Only few studies have systematically investigated neuropsychiatric aspects in patients with Cushing's disease (CD). Pain syndromes have been described in patients with pituitary adenomas, but so far no systematical investigation has been conducted in patients with CD. Additionally, CD has an association with cardiometabolic comorbidities which ultimately leads to increased morbidity and mortality. Long-term treatment of the hypercortisolic state cannot prevent the persistence of...

  1. A New Zealand based cohort study of anaesthetic trainees' career outcomes compared with previously expressed intentions.

    Science.gov (United States)

    Moran, E M L; French, R A; Kennedy, R R

    2011-09-01

    Predicting workforce requirements is a difficult but necessary part of health resource planning. A 'snapshot' workforce survey undertaken in 2002 examined issues that New Zealand anaesthesia trainees expected would influence their choice of future workplace. We have restudied the same cohort to see if that workforce survey was a good predictor of outcome. Seventy (51%) of 138 surveys were completed in 2009 compared with 100 (80%) of 138 in the 2002 survey. Eighty percent of the 2002 respondents planned consultant positions in New Zealand. We found 64% of respondents were working in New Zealand (P New Zealand based respondents but only 40% of those living outside New Zealand agreed or strongly agreed with this statement (P New Zealand but was important for only 2% of those resident in New Zealand (P New Zealand were predominantly between NZ$150,000 and $200,000 while those overseas received between NZ$300,000 and $400,000. Of those that are resident in New Zealand, 84% had studied in a New Zealand medical school compared with 52% of those currently working overseas (P < 0.01). Our study shows that stated career intentions in a group do not predict the actual group outcomes. We suggest that 'snapshot' studies examining workforce intentions are of little value for workforce planning. However we believe an ongoing program matching career aspirations against career outcomes would be a useful tool in workforce planning.

  2. Life cycle impact assessment of ammonia production in Algeria: A comparison with previous studies

    Energy Technology Data Exchange (ETDEWEB)

    Makhlouf, Ali, E-mail: almakhsme@gmail.com; Serradj, Tayeb; Cheniti, Hamza

    2015-01-15

    In this paper, a Life Cycle Analysis (LCA) from “cradle to gate” of one anhydrous ton of ammonia with a purity of 99% was achieved. Particularly, the energy and environmental performance of the product (ammonia) were evaluated. The eco-profile of the product and the share of each stage of the Life Cycle on the whole environmental impacts have been evaluated. The flows of material and energy for each phase of the life cycle were counted and the associated environmental problems were identified. Evaluation of the impact was achieved using GEMIS 4.7 software. The primary data collection was executed at the production installations located in Algeria (Annaba locality). The analysis was conducted according to the LCA standards ISO 14040 series. The results show that Cumulative Energy Requirement (CER) is of 51.945 × 10{sup 3} MJ/t of ammonia, which is higher than the global average. Global Warming Potential (GWP) is of 1.44 t CO{sub 2} eq/t of ammonia; this value is lower than the world average. Tropospheric ozone precursor and Acidification are also studied in this article, their values are: 549.3 × 10{sup −6} t NMVOC eq and 259.3 × 10{sup −6} t SO{sub 2} eq respectively.

  3. Life cycle impact assessment of ammonia production in Algeria: A comparison with previous studies

    International Nuclear Information System (INIS)

    Makhlouf, Ali; Serradj, Tayeb; Cheniti, Hamza

    2015-01-01

    In this paper, a Life Cycle Analysis (LCA) from “cradle to gate” of one anhydrous ton of ammonia with a purity of 99% was achieved. Particularly, the energy and environmental performance of the product (ammonia) were evaluated. The eco-profile of the product and the share of each stage of the Life Cycle on the whole environmental impacts have been evaluated. The flows of material and energy for each phase of the life cycle were counted and the associated environmental problems were identified. Evaluation of the impact was achieved using GEMIS 4.7 software. The primary data collection was executed at the production installations located in Algeria (Annaba locality). The analysis was conducted according to the LCA standards ISO 14040 series. The results show that Cumulative Energy Requirement (CER) is of 51.945 × 10 3 MJ/t of ammonia, which is higher than the global average. Global Warming Potential (GWP) is of 1.44 t CO 2 eq/t of ammonia; this value is lower than the world average. Tropospheric ozone precursor and Acidification are also studied in this article, their values are: 549.3 × 10 −6 t NMVOC eq and 259.3 × 10 −6 t SO 2 eq respectively

  4. Radiation studies in the antiproton source

    International Nuclear Information System (INIS)

    Church, M.

    1990-01-01

    Experiment E760 has a lead glass (Pb-G) calorimeter situated in the antiproton source tunnel in the accumulator ring at location A50. This location is exposed to radiation from several sources during antiproton stacking operations. A series of radiation studies has been performed over the last two years to determine the sources of this radiation and as a result, some shielding has been installed in the antiproton source in order to protect the lead glass from radiation damage

  5. Ifosfamide in previously untreated disseminated neuroblastoma. Results of Study 3A of the European Neuroblastoma Study Group.

    Science.gov (United States)

    Kellie, S J; De Kraker, J; Lilleyman, J S; Bowman, A; Pritchard, J

    1988-05-01

    A prospective study of the effectiveness of ifosfamide as a single agent in the management of previously untreated patients with Evans stage IV neuroblastoma was undertaken. Eighteen children aged more than 1 year were treated with ifosfamide (IFX) 3 g/m2 daily for 2 days immediately after diagnosis and 3 weeks later. Treatment was continued with combination chemotherapy using vincristine, cyclophosphamide, cisplatinum and etoposide (OPEC) or a variant. Mesna (2-mercaptoethane sulphonate) was given to all patients during IFX treatment to prevent urotoxicity. Eight of the 18 patients (44%) responded to IFX. Nine had greater than 66% reduction in baseline tumor volume. Of 15 evaluable patients with raised pre-treatment urinary catecholamine excretion, six (40%) achieved greater than 50% reduction in pretreatment levels. Two of 10 patients evaluable for bone marrow response had complete clearance. Toxicity was mild in all patients. Upon completing 'first line' therapy, only four patients (22%) achieved a good partial remission (GPR) or complete response (CR). Median survival was 11 months. There was a lower rate of attaining GPR and shortened median survival in patients receiving phase II IFX before OPEC or variant, compared to patients with similar pre-treatment characteristics treated with OPEC from diagnosis in an earlier study.

  6. Study of the 137Cs Stabilizer Source

    Directory of Open Access Journals (Sweden)

    GAO Yan;WANG Yan-ling;XU Zhi-jian;XU Liang;REN Chun-xia;TAN Xiao-ming;CUI Hong-qi

    2014-02-01

    Full Text Available The attenuation laws of the Cesium -137 γ-ray penetrating the ceramic core、stainless steel and tungsten steel were studied. The radioactivity of the 137Cs stabilizer source was determined through the surface dose rate of 137Cs stabilizer sources. In addition, the adsorption properties of the ceramic core were studied to improve the stability of the output rate, and established a production line. The application results showed that the output rate of ray source was accurate and was of a good consistency. At present, the source had been used in logging lithology, and achieved the realization of domestic product.

  7. Estimating the effect of current, previous and never use of drugs in studies based on prescription registries

    DEFF Research Database (Denmark)

    Nielsen, Lars Hougaard; Løkkegaard, Ellen; Andreasen, Anne Helms

    2009-01-01

    of this misclassification for analysing the risk of breast cancer. MATERIALS AND METHODS: Prescription data were obtained from Danish Registry of Medicinal Products Statistics and we applied various methods to approximate treatment episodes. We analysed the duration of HT episodes to study the ability to identify......PURPOSE: Many studies which investigate the effect of drugs categorize the exposure variable into never, current, and previous use of the study drug. When prescription registries are used to make this categorization, the exposure variable possibly gets misclassified since the registries do...... not carry any information on the time of discontinuation of treatment.In this study, we investigated the amount of misclassification of exposure (never, current, previous use) to hormone therapy (HT) when the exposure variable was based on prescription data. Furthermore, we evaluated the significance...

  8. An fMRI study of neuronal activation in schizophrenia patients with and without previous cannabis use

    Directory of Open Access Journals (Sweden)

    Else-Marie eLøberg

    2012-10-01

    Full Text Available Previous studies have mostly shown positive effects of cannabis use on cognition in patients with schizophrenia, which could reflect lower neurocognitive vulnerability. There are however no studies comparing whether such cognitive differences have neuronal correlates. Thus, the aim of the present study was to compare whether patients with previous cannabis use differ in brain activation from patients who has never used cannabis. The patients groups were compared on the ability to up-regulate an effort mode network during a cognitive task and down-regulate activation in the same network during a task-absent condition. Task-present and task-absent brain activation was measured by functional magnetic resonance neuroimaging (fMRI. Twenty-six patients with a DSM-IV and ICD-10 diagnosis of schizophrenia were grouped into a previous cannabis user group and a no-cannabis group. An auditory dichotic listening task with instructions of attention focus on either the right or left ear stimulus was used to tap verbal processing, attention and cognitive control, calculated as an aggregate score. When comparing the two groups, there were remaining activations in the task-present condition for the cannabis group, not seen in the no-cannabis group, while there was remaining activation in the task-absent condition for the no-cannabis group, not seen in the cannabis group. Thus, the patients with previous cannabis use showed increased activation in an effort mode network and decreased activation in the default mode network as compared to the no-cannabis group. It is concluded that the present study show some differences in brain activation to a cognitively challenging task between previous cannabis and no-cannabis schizophrenia patients.

  9. Lattice Study for the Taiwan Photon Source

    CERN Document Server

    Kuo, Chin-Cheng; Chen Chien Te; Luo, Gwo-Huei; Tsai, Hung-Jen; Wang, Min-Huey

    2005-01-01

    The feasibility study for the new 3.0~3.3 GeV Taiwan synchrotron light source, dubbed Taiwan Photon Source, was initiated in July, 2004. The goal is to construct a high performance light source with extremely bright X-ray in complementary to the existing 1.5 GeV light source in Taiwan. The ring circumference is 518.4 m and a 24-cell DBA lattice structure is chosen. The natural emittance with distributed dispersion is less than 2 nm-rad. A large booster ring of 499.2 m sharing the storage ring tunnel will be adopted.

  10. Statistical studies of powerful extragalactic radio sources

    Energy Technology Data Exchange (ETDEWEB)

    Macklin, J T

    1981-01-01

    This dissertation is mainly about the use of efficient statistical tests to study the properties of powerful extragalactic radio sources. Most of the analysis is based on subsets of a sample of 166 bright (3CR) sources selected at 178 MHz. The first chapter is introductory and it is followed by three on the misalignment and symmetry of double radio sources. The properties of nuclear components in extragalactic sources are discussed in the next chapter, using statistical tests which make efficient use of upper limits, often the only available information on the flux density from the nuclear component. Multifrequency observations of four 3CR sources are presented in the next chapter. The penultimate chapter is about the analysis of correlations involving more than two variables. The Spearman partial rank correlation coefficient is shown to be the most powerful test available which is based on non-parametric statistics. It is therefore used to study the dependences of the properties of sources on their size at constant redshift, and the results are interpreted in terms of source evolution. Correlations of source properties with luminosity and redshift are then examined.

  11. Dexamethasone intravitreal implant in previously treated patients with diabetic macular edema : Subgroup analysis of the MEAD study

    OpenAIRE

    Augustin, A.J.; Kuppermann, B.D.; Lanzetta, P.; Loewenstein, A.; Li, X.; Cui, H.; Hashad, Y.; Whitcup, S.M.; Abujamra, S.; Acton, J.; Ali, F.; Antoszyk, A.; Awh, C.C.; Barak, A.; Bartz-Schmidt, K.U.

    2015-01-01

    Background Dexamethasone intravitreal implant 0.7?mg (DEX 0.7) was approved for treatment of diabetic macular edema (DME) after demonstration of its efficacy and safety in the MEAD registration trials. We performed subgroup analysis of MEAD study results to evaluate the efficacy and safety of DEX 0.7 treatment in patients with previously treated DME. Methods Three-year, randomized, sham-controlled phase 3 study in patients with DME, best-corrected visual acuity (BCVA) of 34?68 Early Treatment...

  12. Youth suicide: an insight into previous hospitalisation for injury and sociodemographic conditions from a nationwide cohort study.

    Science.gov (United States)

    Zambon, Francesco; Laflamme, Lucie; Spolaore, Paolo; Visentin, Cristiana; Hasselberg, Marie

    2011-06-01

    This study investigates the degree to which a previous hospitalisation for injury of any intent is a risk of subsequent youth suicide and whether this association is influenced by family socioeconomic status or economic stress. A nationwide register-based cohort study was conducted covering all Swedish subjects born between January 1977 and December 1991 (N=1,616,342, male/female ratio=1.05). The cohort subjects were followed-up from January 1998 to December 2003, when aged 7-26 years. Poisson regression and the likelihood ratio test (95% CI) were used to assess the age-adjusted effect of hospitalisation for injuries of various intent on youth suicide and its effect once adjusted for family sociodemographic and social circumstances. Each set of exposures was associated independently and significantly with suicide mortality. Being hospitalised for self-inflicted injuries or injuries of undetermined intent was associated with a risk of suicide 36 to 47 times, respectively, that of subjects never hospitalised in the period under study (95% CI 28.36 to 45.58 and 26.67 to 83.87 for self-inflicted injuries and for events of undetermined intent, respectively; overall psuicide (RR 3.08; 95% CI 2.26 to 4.19). These effects were solid and not substantially altered after adjustment for family demographic and socioeconomic circumstances. A strong association exists between previous hospitalisation for injury of any intent and youth suicide. The association is robust and unaltered by family socioeconomic circumstances.

  13. Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women

    Science.gov (United States)

    Gehlbach, Stephen; Saag, Kenneth G.; Adachi, Jonathan D.; Hooven, Fred H.; Flahive, Julie; Boonen, Steven; Chapurlat, Roland D.; Compston, Juliet E.; Cooper, Cyrus; Díez-Perez, Adolfo; Greenspan, Susan L.; LaCroix, Andrea Z.; Netelenbos, J. Coen; Pfeilschifter, Johannes; Rossini, Maurizio; Roux, Christian; Sambrook, Philip N.; Silverman, Stuart; Siris, Ethel S.; Watts, Nelson B.; Lindsay, Robert

    2016-01-01

    Previous fractures of the hip, spine, or wrist are well-recognized predictors of future fracture, but the role of other fracture sites is less clear. We sought to assess the relationship between prior fracture at 10 skeletal locations and incident fracture. The Global Longitudinal Study of Osteoporosis in Women (GLOW) is an observational cohort study being conducted in 17 physician practices in 10 countries. Women ≥ 55 years answered questionnaires at baseline and at 1 and/or 2 years (fractures in previous year). Of 60,393 women enrolled, follow-up data were available for 51,762. Of these, 17.6%, 4.0%, and 1.6% had suffered 1, 2, or ≥3 fractures since age 45. During the first 2 years of follow-up, 3149 women suffered 3683 incident fractures. Compared with women with no prior fractures, women with 1, 2, or ≥ 3 prior fractures were 1.8-, 3.0-, and 4.8-fold more likely to have any incident fracture; those with ≥3 prior fractures were 9.1-fold more likely to sustain a new vertebral fracture. Nine of 10 prior fracture locations were associated with an incident fracture. The strongest predictors of incident spine and hip fractures were prior spine fracture (hazard ratio 7.3) and hip (hazard ratio 3.5). Prior rib fractures were associated with a 2.3-fold risk of subsequent vertebral fracture, previous upper leg fracture predicted a 2.2-fold increased risk of hip fracture; women with a history of ankle fracture were at 1.8-fold risk of future fracture of a weight-bearing bone. Our findings suggest that a broad range of prior fracture sites are associated with an increased risk of incident fractures, with important implications for clinical assessments and risk model development. PMID:22113888

  14. Previous experiences and emotional baggage as barriers to lifestyle change - a qualitative study of Norwegian Healthy Life Centre participants.

    Science.gov (United States)

    Følling, Ingrid S; Solbjør, Marit; Helvik, Anne-S

    2015-06-23

    Changing lifestyle is challenging and difficult. The Norwegian Directorate of Health recommends that all municipalities establish Healthy Life Centres targeted to people with lifestyle issues. Little is known about the background, experiences and reflections of participants. More information is needed about participants to shape effective lifestyle interventions with lasting effect. This study explores how participants in a lifestyle intervention programme describe previous life experiences in relation to changing lifestyle. Semi-structured qualitative in-depth interviews were performed with 23 participants (16 women and 7 men) aged 18 - 70 years. The data were analysed using systematic text condensation searching for issues describing participants' responses, and looking for the essence, aiming to share the basis of life-world experiences as valid knowledge. Participants identified two main themes: being stuck in old habits, and being burdened with emotional baggage from their previous negative experiences. Participants expressed a wish to change their lifestyles, but were unable to act in accordance with the health knowledge they possessed. Previous experiences with lifestyle change kept them from initiating attempts without professional assistance. Participants also described being burdened by an emotional baggage with problems from childhood and/or with family, work and social life issues. Respondents said that they felt that emotional baggage was an important explanation for why they were stuck in old habits and that conversely, being stuck in old habits added load to their already emotional baggage and made it heavier. Behavioural change can be hard to perform as psychological distress from life baggage can influence the ability to change. The study participants' experience of being stuck in old habits and having substantial emotional baggage raises questions as to whether or not Healthy Life Centres are able to help participants who need to make a lifestyle

  15. Everolimus for Previously Treated Advanced Gastric Cancer: Results of the Randomized, Double-Blind, Phase III GRANITE-1 Study

    Science.gov (United States)

    Ohtsu, Atsushi; Ajani, Jaffer A.; Bai, Yu-Xian; Bang, Yung-Jue; Chung, Hyun-Cheol; Pan, Hong-Ming; Sahmoud, Tarek; Shen, Lin; Yeh, Kun-Huei; Chin, Keisho; Muro, Kei; Kim, Yeul Hong; Ferry, David; Tebbutt, Niall C.; Al-Batran, Salah-Eddin; Smith, Heind; Costantini, Chiara; Rizvi, Syed; Lebwohl, David; Van Cutsem, Eric

    2013-01-01

    Purpose The oral mammalian target of rapamycin inhibitor everolimus demonstrated promising efficacy in a phase II study of pretreated advanced gastric cancer. This international, double-blind, phase III study compared everolimus efficacy and safety with that of best supportive care (BSC) in previously treated advanced gastric cancer. Patients and Methods Patients with advanced gastric cancer that progressed after one or two lines of systemic chemotherapy were randomly assigned to everolimus 10 mg/d (assignment schedule: 2:1) or matching placebo, both given with BSC. Randomization was stratified by previous chemotherapy lines (one v two) and region (Asia v rest of the world [ROW]). Treatment continued until disease progression or intolerable toxicity. Primary end point was overall survival (OS). Secondary end points included progression-free survival (PFS), overall response rate, and safety. Results Six hundred fifty-six patients (median age, 62.0 years; 73.6% male) were enrolled. Median OS was 5.4 months with everolimus and 4.3 months with placebo (hazard ratio, 0.90; 95% CI, 0.75 to 1.08; P = .124). Median PFS was 1.7 months and 1.4 months in the everolimus and placebo arms, respectively (hazard ratio, 0.66; 95% CI, 0.56 to 0.78). Common grade 3/4 adverse events included anemia, decreased appetite, and fatigue. The safety profile was similar in patients enrolled in Asia versus ROW. Conclusion Compared with BSC, everolimus did not significantly improve overall survival for advanced gastric cancer that progressed after one or two lines of previous systemic chemotherapy. The safety profile observed for everolimus was consistent with that observed for everolimus in other cancers. PMID:24043745

  16. Study of extragalactic sources with H.E.S.S

    International Nuclear Information System (INIS)

    Giebels, Berrie

    2007-01-01

    The field of Very High Energy (VHE) γ-ray emitting extragalactic sources has considerably evolved since the new generation of atmospheric Cerenkov telescopes (ACT) of improved sensitivity, such as H.E.S.S. array and the MAGIC ACT, have started operating. This has led to a wealth of new clues about emission mechanisms at high energy through the discovery of new sources, more accurate spectra and temporal studies of sources known previously, and simultaneous multi-wavelength (MWL) campaigns since broad band variability is a key phenomenon to the underlying physical mechanisms at play. The fact that some of these new sources are located at redshifts close to z ∼ 0.2 makes them powerful probes of the Extragalactic Background Light (EBL) through the attenuation of γ-rays above 100 GeV

  17. Doxorubicin and ifosfamide combination chemotherapy in previously treated acute leukemia in adults: a Southwest Oncology Group pilot study.

    Science.gov (United States)

    Ryan, D H; Bickers, J N; Vial, R H; Hussein, K; Bottomley, R; Hewlett, J S; Wilson, H E; Stuckey, W J

    1980-01-01

    The Southwest Oncology Group did a limited institutional pilot study of the combination of doxorubicin and ifosfamide in the treatment of previously treated adult patients with acute leukemia. Thirty-four patients received one or two courses of the combination. All patients had received prior chemotherapy and 32 had received prior anthracycline chemotherapy. Three patients died before their responses could be fully evaluated. Fourteen patients achieved complete remission (41%) and one patient achieved partial remission. The complete remission rate was 27% for patients with acute myeloblastic leukemia (myelomonoblastic leukemia, monoblastic leukemia, and erythroleukemia) and 89% for patients with acute lymphocytic and undifferentiated leukemia (ALL). Toxic effects included severe hematologic reactions in 33 of 34 patients, hematuria in six patients, altered sensorium in one patient, and congestive heart failure in one patient. The safety of the combination was established and toxic side effects of this therapy were tolerable. The 89% complete remission rate for previously treated patients with ALL suggests that the combination of doxorubicin and ifosfamide may be particularly effective in ALL.

  18. Treatment satisfaction with paliperidone extended-release tablets: open-label study in schizophrenia patients dissatisfied with previous antipsychotic medication

    Directory of Open Access Journals (Sweden)

    Yang FD

    2017-04-01

    Full Text Available Fu De Yang,1 Juan Li,1 Yun Long Tan,1 Wei Ye Liang,1 Rongzhen Zhang,1 Ning Wang,1 Wei Feng,1 Shangli Cai,2 Jian Min Zhuo,2 Li Li Zhang2 1Beijing Hui-Long-Guan Hospital, 2Department of Medical Affairs, Xian Janssen Pharmaceutical Ltd, Beijing, People’s Republic of China Objective: The aim of this study was to evaluate the changes in treatment satisfaction after switching to paliperidone extended-release (ER in Chinese schizophrenia patients dissatisfied with their previous antipsychotic treatment.Methods: In this 8-week, open-label, single-arm, multicenter, prospective study, 1,693 patients dissatisfied with previous antipsychotic medication were enrolled and switched to paliperidone ER tablets (3–12 mg/d based on clinical judgment. The primary efficacy end point was change in Medication Satisfaction Questionnaire (MSQ score from baseline to week 8. The secondary end points included percentage of patients with MSQ score ≥4, as well as changes in Clinical Global Improvement-Severity (CGI-S and Personal and Social Performance (PSP scores.Results: MSQ scores increased significantly from baseline (mean [standard deviation {SD}]: 2.48 [0.55] to week 8 (5.47 [0.89], P<0.0001; primary end point, full analysis set. The percentage of patients with MSQ score ≥4 was 95.9% at week 8, indicating that most of the patients were satisfied with their treatment. Significant (P<0.0001 improvements from baseline to week 8 were noted in CGI-S score (2.37 [1.20] and PSP score (25.5 [15.0]. A total of 174 (10.28% patients experienced adverse events (AEs. The most common (>10 patients events were extrapyramidal disorder (n=84, 4.96%, poor quality sleep (n=18, 1.06% and akathisia (n=13, 0.77%. The majority of AEs were mild to moderate in severity. No deaths occurred.Conclusion: Treatment satisfaction improved after switching to paliperidone ER from the previous antipsychotic in Chinese patients with schizophrenia. Keywords: atypical antipsychotics, open label

  19. Studies and modeling of cold neutron sources

    International Nuclear Information System (INIS)

    Campioni, G.

    2004-11-01

    With the purpose of updating knowledge in the fields of cold neutron sources, the work of this thesis has been run according to the 3 following axes. First, the gathering of specific information forming the materials of this work. This set of knowledge covers the following fields: cold neutron, cross-sections for the different cold moderators, flux slowing down, different measurements of the cold flux and finally, issues in the thermal analysis of the problem. Secondly, the study and development of suitable computation tools. After an analysis of the problem, several tools have been planed, implemented and tested in the 3-dimensional radiation transport code Tripoli-4. In particular, a module of uncoupling, integrated in the official version of Tripoli-4, can perform Monte-Carlo parametric studies with a spare factor of Cpu time fetching 50 times. A module of coupling, simulating neutron guides, has also been developed and implemented in the Monte-Carlo code McStas. Thirdly, achieving a complete study for the validation of the installed calculation chain. These studies focus on 3 cold sources currently functioning: SP1 from Orphee reactor and 2 other sources (SFH and SFV) from the HFR at the Laue Langevin Institute. These studies give examples of problems and methods for the design of future cold sources

  20. Overview of receptor-based source apportionment studies for speciated atmospheric mercury

    OpenAIRE

    Cheng, I.; Xu, X.; Zhang, L.

    2015-01-01

    Receptor-based source apportionment studies of speciated atmospheric mercury are not only concerned with source contributions but also with the influence of transport, transformation, and deposition processes on speciated atmospheric mercury concentrations at receptor locations. Previous studies applied multivariate receptor models including principal components analysis and positive matrix factorization, and back trajectory receptor models including potential source contri...

  1. Value and reliability of findings from previous epidemiologic studies in the assessment of radiation-related cancer risks. Pt. 3

    International Nuclear Information System (INIS)

    Frasch, G.; Martignoni, K.

    1990-01-01

    The theories put forward here are predominantly based on pooled data from previous studies in a number of cohorts made up by mostly non-average individuals. These studies were carried out by various researchers and differed in procedures and aims. Factors of major importance to the validity and reliability of the conclusions drawn from this study are pointed out. In one chapter some light is thrown on factors known to bear a relation to the incidence of radiation-induced cancer of the breast, even though at present this can only very vaguely be described on a quantitative basis. These factors include fractionated dose regimens, pregnancies and parturitions, menarche, menopause, synergisms as well as secondary cancer of the breast. The available body of evidence suggests that exposure of each of 1 million women to a dose of 10 mGy (rad) can be linked with approx. 3 additional cases of mammary cancer reported on an average per year after the latency period. The fact that there is some statistical scatter around this value is chiefly attributable to age-related causes at the beginning of exposure. Differences in ethnic and cultural characteristics between the populations investigated appeared to be less important here. (orig./MG) [de

  2. Barriers to postpartum screening for type 2 diabetes: a qualitative study of women with previous gestational diabetes.

    Science.gov (United States)

    Rafii, Forough; Rahimparvar, Seyedeh Fatemeh Vasegh; Mehrdad, Neda; Keramat, Afsaneh

    2017-01-01

    Risk of developing type 2 diabetes is increased in women with previous gestational diabetes mellitus (GDM). Postpartum glycemic screening is recommended in women with recent GDM. But this screening rate is low and the reasons are unclear. The aim of this study was to explore the experiences of Iranian women with recent GDM on barriers of postpartum screening for diabetes. This qualitative study was conducted in Tehran, Iran in 2016. Semi-structured interview was used for data collection. 22 women with recent GDM were interviewed. These women gave birth in Tehran hospitals at a minimum of 6 months before interview. The missed screening defined as not attending to laboratory for Fasting Blood Sugar and/or Oral Glucose Tolerance Test, 6 week to 6 month after their child birthing. The data was analyzed by content analysis method. Themes and sub-themes that illustrated the barriers to postpartum diabetes screening were: inadequate education (about developing diabetes in the future, implementation of the screening, and glucometer validity in diagnosis of diabetes), perceiving the screening as difficult (feeling comfortable with the glucometer, poor laboratory conditions, issues related to the baby/babies, and financial problems), improper attitudes toward the screening (unwilling to get diagnosed, not giving priority to oneself, having false beliefs) and procrastination (gap to intention and action, self-deception and self-regulation failure). Women with recent GDM reported several barriers for postpartum diabetes screening. This study help to develop the evidence-based interventions for improving this screening rate.

  3. GLOBAL SOURCING: A THEORETICAL STUDY ON TURKEY

    Directory of Open Access Journals (Sweden)

    Aytac GOKMEN

    2010-07-01

    Full Text Available Global sourcing is to source from the global market for goods and services across national boundaries in order to take advantage of the global efficiencies in the delivery of a product or service. Such efficiencies are consists of low cost skilled labor, low cost raw materials and other economic factors like tax breaks and deductions as well as low trade tariffs. When we assess the case regarding to Turkey, global sourcing is an effective device for some firms. The domestic firms in Turkey at various industries are inclined to global source finished or intermediate goods from the world markets, finish the production process in Turkey and export. Eventually, on the one hand the export volume of Turkey increases, but on the other hand the import of a considerable volume of finished or intermediate goods bring about a negative trade balance and loss of jobs in Turkey. Therefore, the objective of this study is to assess the concept of global sourcing transactions on Turkey resting on comprehensive publications.

  4. A Flexible-Dose Study of Paliperidone ER in Patients With Nonacute Schizophrenia Previously Treated Unsuccessfully With Oral Olanzapine.

    Science.gov (United States)

    Kotler, Moshe; Dilbaz, Nesrin; Rosa, Fernanda; Paterakis, Periklis; Milanova, Vihra; Smulevich, Anatoly B; Lahaye, Marjolein; Schreiner, Andreas

    2016-01-01

    The goal of this study was to explore the tolerability, safety, and treatment response of switching from oral olanzapine to paliperidone extended release (ER). Adult patients with nonacute schizophrenia who had been treated unsuccessfully with oral olanzapine were switched to flexible doses of paliperidone ER (3 to 12 mg/d). The primary efficacy outcome was a ≥ 20% improvement in Positive and Negative Syndrome Scale (PANSS) total scores from baseline to endpoint for patients who switched medications because of lack of efficacy with olanzapine and noninferiority versus previous olanzapine treatment (mean endpoint change in PANSS total scores vs. baseline of ≤ 5 points) for patients who switched for reasons other than lack of efficacy. Safety and tolerability were assessed by monitoring adverse events, extrapyramidal symptoms, and weight change. Of 396 patients, 65.2% were men, mean age was 40.0 ± 12.0 years, and 75.5% had paranoid schizophrenia. Among the patients whose main reason for switching was lack of efficacy, an improvement in the PANSS total score of ≥ 20% occurred in 57.4% of patients. Noninferiority was confirmed for each subgroup of patients whose main reason for switching was something other than lack of efficacy. Paliperidone ER was generally well tolerated. Extrapyramidal symptoms as measured by total Extrapyramidal Symptom Rating Scale scores showed statistically significant and clinically relevant improvements at endpoint, the average weight decreased by 0.8 ± 5.2 kg at endpoint, and a clinically relevant weight gain of ≥ 7% occurred in 8.0% of patients. Paliperidone ER flexibly-dosed over 6 months was well tolerated and associated with a meaningful clinical response in patients with nonacute schizophrenia who had previously been unsuccessfully treated with oral olanzapine.

  5. Pilot Study of an Individualised Early Postpartum Intervention to Increase Physical Activity in Women with Previous Gestational Diabetes

    Directory of Open Access Journals (Sweden)

    Harold David McIntyre

    2012-01-01

    Full Text Available Optimal strategies to prevent progression towards overt diabetes in women with recent gestational diabetes remain ill defined. We report a pilot study of a convenient, home based exercise program with telephone support, suited to the early post-partum period. Twenty eight women with recent gestational diabetes were enrolled at six weeks post-partum into a 12 week randomised controlled trial of Usual Care (n=13 versus Supported Care (individualised exercise program with regular telephone support; n=15. Baseline characteristics (Mean ± SD were: Age  33±4  years; Weight 80 ± 20 kg and Body Mass Index (BMI 30.0±9.7 kg/m2. The primary outcome, planned physical activity {Median (Range}, increased by 60 (0–540 mins/week in the SC group versus 0 (0–580 mins/week in the UC group (P=0.234. Walking was the predominant physical activity. Body weight, BMI, waist circumference, % body fat, fasting glucose and insulin did not change significantly over time in either group. This intervention designed to increase physical activity in post-partum women with previous gestational diabetes proved feasible. However, no measurable improvement in metabolic or biometric parameters was observed over a three month period.

  6. Patterns and Determinants of Treatment Seeking among Previously Untreated Psychotic Patients in Aceh Province, Indonesia: A Qualitative Study

    Directory of Open Access Journals (Sweden)

    Marthoenis Marthoenis

    2016-01-01

    Full Text Available Immediate treatment of first-episode psychosis is essential in order to achieve a positive outcome. However, Indonesian psychiatric patients often delay accessing health services, the reason for which is not yet fully understood. The current study aimed to understand patterns of treatment seeking and to reveal determinants of the delay in accessing psychiatric care among first-time user psychotic patients. Qualitative interviews were conducted with sixteen family members who accompanied the patients to a psychiatric hospital. Many families expressed beliefs that mental illness appertains to village sickness and not hospital sickness; therefore, they usually take the patients to traditional or religious healers before taking them to a health professional. They also identified various factors that potentially delay accessing psychiatric treatment: low literacy and beliefs about the cause of the illness, stigmatisation, the role of extended family, financial problems, and long distance to the psychiatric hospital. On the other hand, the family mentioned various factors related to timely help seeking, including being a well-educated family, living closer to health facilities, previous experience of successful psychotic therapy, and having more positive symptoms of psychosis. The findings call for mental health awareness campaigns in the community.

  7. A Questionnaire Study on the Attitudes and Previous Experience of Croatian Family Physicians toward their Preparedness for Disaster Management.

    Science.gov (United States)

    Pekez-Pavliško, Tanja; Račić, Maja; Jurišić, Dinka

    2018-04-01

    To explore family physicians' attitudes, previous experience and self-assessed preparedness to respond or to assist in mass casualty incidents in Croatia. The cross-sectional survey was carried out during January 2017. Study participants were recruited through a Facebook group that brings together family physicians from Croatia. They were asked to complete the questionnaire, which was distributed via google.docs. Knowledge and attitudes toward disaster preparedness were evaluated by 18 questions. Analysis of variance, Student t test and Kruskal-Wallis test t were used for statistical analysis. Risk awareness of disasters was high among respondents (M = 4.89, SD=0.450). Only 16.4 of respondents have participated in the management of disaster at the scene. The majority (73.8%) of physicians have not been participating in any educational activity dealing with disaster over the past two years. Family physicians believed they are not well prepared to participate in national (M = 3.02, SD=0.856) and local community emergency response system for disaster (M = 3.16, SD=1.119). Male physicians scored higher preparedness to participate in national emergency response system for disaster ( p =0.012), to carry out accepted triage principles used in the disaster situation ( p =0.003) and recognize differences in health assessments indicating potential exposure to specific agents ( p =0,001) compared to their female colleagues. Croatian primary healthcare system attracts many young physicians, who can be an important part of disaster and emergency management. However, the lack of experience despite a high motivation indicates a need for inclusion of disaster medicine training during undergraduate studies and annual educational activities.

  8. Previous injuries and some training characteristics predict running-related injuries in recreational runners: a prospective cohort study.

    Science.gov (United States)

    Hespanhol Junior, Luiz Carlos; Pena Costa, Leonardo Oliveira; Lopes, Alexandre Dias

    2013-12-01

    What is the incidence of running-related injuries (RRIs) in recreational runners? Which personal and training characteristics predict RRIs in recreational runners? Prospective cohort study. A total of 200 recreational runners answered a fortnightly online survey containing questions about their running routine, races, and presence of RRI. These runners were followed-up for a period of 12 weeks. The primary outcome of this study was running-related injury. The incidence of injuries was calculated taking into account the exposure to running and was expressed by RRI/1000 hours. The association between potential predictive factors and RRIs was estimated using generalised estimating equation models. A total of 84 RRIs were registered in 60 (31%) of the 191 recreational runners who completed all follow-up surveys. Of the injured runners 30% (n=18/60) developed two or more RRIs, with 5/18 (28%) being recurrences. The incidence of RRI was 10 RRI/1000 hours of running exposure. The main type of RRI observed was muscle injuries (30%, n=25/84). The knee was the most commonly affected anatomical region (19%, n=16/84). The variables associated with RRI were: previous RRI (OR 1.88, 95% CI 1.01 to 3.51), duration of training although the effect was very small (OR 1.01, 95% CI 1.00 to 1.02), speed training (OR 1.46, 95% CI 1.02 to 2.10), and interval training (OR 0.61, 95% CI 0.43 to 0.88). Physiotherapists should be aware and advise runners that past RRI and speed training are associated with increased risk of further RRI, while interval training is associated with lower risk, although these associations may not be causative. Copyright © 2013 Australian Physiotherapy Association. Published by Elsevier B.V. All rights reserved.

  9. Blood donations from previously transfused or pregnant donors: a multicenter study to determine the frequency of alloexposure.

    Science.gov (United States)

    Rios, Jorge A; Schlumpf, Karen S; Kakaiya, Ram M; Triulzi, Darrell J; Roback, John D; Kleinman, Steve H; Murphy, Edward L; Gottschall, Jerome L; Carey, Patricia M

    2011-06-01

    Transfusion-related acute lung injury (TRALI) mitigation strategies include the deferral of female donors from apheresis platelet (PLT) donations and the distribution of plasma for transfusion from male donors only. We studied the implications of these policies in terms of component loss at six blood centers in the United States. We collected data from allogeneic blood donors making whole blood and blood component donations during calendar years 2006 through 2008. We analyzed the distribution of donations in terms of the sex, transfusion and pregnancy histories, and blood type. A TRALI mitigation policy that would not allow plasma from female whole blood donors to be prepared into transfusable plasma components would result in nearly a 50% reduction in the units of whole blood available for plasma manufacturing and would decrease the number of type AB plasma units that could be made from whole blood donations by the same amount. Deferral of all female apheresis PLT donors, all female apheresis PLT donors with histories of prior pregnancies, or all female apheresis PLT donors with histories of prior pregnancies and positive screening test results for antibodies to human leukocyte antigens (HLAs) will result in a loss of 37.1, 22.5, and 5.4% of all apheresis PLT donations, respectively. A TRALI mitigation policy that only defers female apheresis PLT donors with previous pregnancies and HLAs would result in an approximately 5% decrease in the inventory of apheresis PLTs, but would eliminate a large proportion of components that are associated with TRALI. © 2010 American Association of Blood Banks.

  10. PCNL - a comparative study in nonoperated and in previously operated (open nephrolithotomy/pyelolithotomy patients - a single-surgeon experience

    Directory of Open Access Journals (Sweden)

    Rahul Gupta

    2011-12-01

    Full Text Available PURPOSE: Re-procedure in patients with history of open stone surgery is usually challenging due to the alteration in the retroperitoneal anatomy. The aim of this study was to determine the possible impact of open renal surgery on the efficacy and morbidity of subsequent percutaneous nephrolithotomy (PCNL. MATERIALS AND METHODS: From March 2009 until September 2010, 120 patients underwent PCNL. Of these, 20 patients were excluded (tubeless or bilateral simultaneous PCNL. Of the remaining 100, 55 primary patients were categorized as Group 1 and the remaining (previous open nephrolithotomy as Group 2. Standard preoperative evaluation was carried out prior to intervention, Statistical analysis was performed using SPSS v. 11 with the chi-square test, independent samples t-test, and Mann-Whitney U test. A p-value < 0.05 was taken as statistically significant. RESULTS: Both groups were similar in demographic profile and stone burden. Attempts to access the PCS was less in Group 1 compared to Group 2 (1.2 + 1 2 vs 3 + 1.3 respectively and this was statistically significant (p < 0.04. However, the mean operative time between the two groups was not statistically significant (p = 0.44. Blood transfusion rate was comparable in the two groups (p = 0.24. One patient in Group 2 developed hemothorax following a supra-11th puncture. Remaining complications were comparable in both groups. CONCLUSION: Patients with past history of renal stone surgery may need more attempts to access the pelvicaliceal system and have difficulty in tract dilation secondary to retroperitoneal scarring. But overall morbidity and efficacy is same in both groups.

  11. Sunburn and sun-protective behaviors among adults with and without previous nonmelanoma skin cancer: a population-based study

    Science.gov (United States)

    Fischer, Alexander H.; Wang, Timothy S.; Yenokyan, Gayane; Kang, Sewon; Chien, Anna L.

    2016-01-01

    Background Individuals with previous nonmelanoma skin cancer (NMSC) are at increased risk for subsequent skin cancer, and should therefore limit UV exposure. Objective To determine whether individuals with previous NMSC engage in better sun protection than those with no skin cancer history. Methods We pooled self-reported data (2005 and 2010 National Health Interview Surveys) from US non-Hispanic white adults (758 with and 34,161 without previous NMSC). We calculated adjusted prevalence odds ratios (aPOR) and 95% confidence intervals (95% CI), taking into account the complex survey design. Results Individuals with previous NMSC versus no history of NMSC had higher rates of frequent use of shade (44.3% versus 27.0%; aPOR=1.41; 1.16–1.71), long sleeves (20.5% versus 7.7%; aPOR=1.55; 1.21–1.98), a wide-brimmed hat (26.1% versus 10.5%; aPOR=1.52; 1.24–1.87), and sunscreen (53.7% versus 33.1%; aPOR=2.11; 95% CI=1.73–2.59), but did not have significantly lower odds of recent sunburn (29.7% versus 40.7%; aPOR=0.95; 0.77–1.17). Among subjects with previous NMSC, recent sunburn was inversely associated with age, sun avoidance, and shade but not sunscreen. Limitations Self-reported cross-sectional data and unavailable information quantifying regular sun exposure. Conclusion Physicians should emphasize sunburn prevention when counseling patients with previous NMSC, especially younger adults, focusing on shade and sun avoidance over sunscreen. PMID:27198078

  12. BNL feasibility studies of spallation neutron sources

    International Nuclear Information System (INIS)

    Lee, Y.Y.; Ruggiero, A.G.; Van Steenbergen, A.; Weng, W.T.

    1995-01-01

    This paper is the summary of conceptual design studies of a 5 MW Pulsed Spallation Neutron Source (PSNS) conducted by an interdepartmental study group at Brookhaven National Laboratory. The study was made of two periods. First, a scenario based on the use of a 600 MeV Linac followed by two fast-cycling 3.6 GeV Synchrotrons was investigated. Then, in a subsequent period, the attention of the study was directed toward an Accumulator scenario with two options: (1) a 1.25 GeV normal conducting Linac followed by two Accumulator Rings, and (2) a 2.4 GeV superconducting Linac followed by a single Accumulator Ring. The study did not make any reference to a specific site

  13. Laparoscopy After Previous Laparotomy

    Directory of Open Access Journals (Sweden)

    Zulfo Godinjak

    2006-11-01

    Full Text Available Following the abdominal surgery, extensive adhesions often occur and they can cause difficulties during laparoscopic operations. However, previous laparotomy is not considered to be a contraindication for laparoscopy. The aim of this study is to present that an insertion of Veres needle in the region of umbilicus is a safe method for creating a pneumoperitoneum for laparoscopic operations after previous laparotomy. In the last three years, we have performed 144 laparoscopic operations in patients that previously underwent one or two laparotomies. Pathology of digestive system, genital organs, Cesarean Section or abdominal war injuries were the most common causes of previouslaparotomy. During those operations or during entering into abdominal cavity we have not experienced any complications, while in 7 patients we performed conversion to laparotomy following the diagnostic laparoscopy. In all patients an insertion of Veres needle and trocar insertion in the umbilical region was performed, namely a technique of closed laparoscopy. Not even in one patient adhesions in the region of umbilicus were found, and no abdominal organs were injured.

  14. Radioimmunotherapy with Y-90-epratuzumab in patients with previously treated B-cell lymphoma. A fractionated dose-escalation study

    International Nuclear Information System (INIS)

    Linden, O.; Cavallin-Stahl, E.; Tennvall, J.; Hindorf, C.; Olsson, T.; Strand, S.E.; Stenberg, L.; Wingardh, K.

    2002-01-01

    Aim: Fractionated RIT may improve outcome by decreasing heterogeneity in absorbed dose and by increasing therapeutic window. The humanised anti-CD22 antibody, Epratuzumab, (Immunomedics, Inc., Morris Plains, NJ) can be given repeatedly with minimal risk of neutralising Ab (HAHA), making fractionated treatment with 90 Y-labelled epratuzumab possible. Materials and Methods: Patients with previously treated B-cell lymphoma received increasing number (2-4) of weekly infusions of 90 Y-epratuzumab. Patients received either 185 MBq/m 2 per infusion (group A), or, if they had a history of high-dose chemotherapy with stem-cell rescue, 92.5 MBq/m 2 per infusion (group B). The first infusion included 150 MBq of 111 Indium for scintigraphic verification of tumour targeting and dosimetry. 1.5 mg/kg epratuzumab was administered with each infusion. The treatment could be repeated once after 3 m. Results: Of 23 patients, 16 in group A and 6 in group B were evaluable for response. The RR in group A was 62% objective response (OR) and 25% CR/CRu. One patient in group B showed OR. OR was seen in aggressive and indolent lymphoma. Response was also long-lasting and event-free survival of patients showing CR/CRu was 14 to 25+ months. In group A all seven patient, receiving three infusions, showed less than grade 3 platelet and neutrophil toxicity, except for two patients suffering grade 3 neutropenia. Of five patients with 4 weekly infusions there were two patients with dose-limiting haematological toxicity (DLT), both recently treated with high dose cytosar before RIT. With criteria used the maximal tolerated dose was three infusions 185 MBq/m 2 . In group B no patient suffered DLT and one patient exhibited OR. Seven patients were retreated after 3 months with minor toxicity, but improvement in OR in two cases. No patient has developed HAHA. CD22 expression on tumour cells, as assessed by flow cytometry, is available in 18 of 22 patients. In group A, seven of eight patients with

  15. sources

    Directory of Open Access Journals (Sweden)

    Shu-Yin Chiang

    2002-01-01

    Full Text Available In this paper, we study the simplified models of the ATM (Asynchronous Transfer Mode multiplexer network with Bernoulli random traffic sources. Based on the model, the performance measures are analyzed by the different output service schemes.

  16. Population studies of the unidentified EGRET sources

    Energy Technology Data Exchange (ETDEWEB)

    Siegal-Gaskins, J M [University of Chicago, Chicago, IL 60637 (United States); Pavlidou, V [University of Chicago, Chicago, IL 60637 (United States); Olinto, A V [University of Chicago, Chicago, IL 60637 (United States); Brown, C [University of Chicago, Chicago, IL 60637 (United States); Fields, B D [University of Illinois at Urbana-Champaign, Urbana, IL 61801 (United States)

    2007-03-15

    The third EGRET catalog contains a large number of unidentified sources. Current data allows the intriguing possibility that some of these objects may represent a new class of yet undiscovered gamma-ray sources. By assuming that galaxies similar to the Milky Way host comparable populations of objects, we constrain the allowed Galactic abundance and distribution of various classes of gamma-ray sources using the EGRET data set. Furthermore, regardless of the nature of the unidentified sources, faint unresolved objects of the same class contribute to the observed diffuse gamma-ray background. We investigate the potential contribution of these unresolved sources to the extragalactic gamma-ray background.

  17. Population studies of the unidentified EGRET sources

    International Nuclear Information System (INIS)

    Siegal-Gaskins, J M; Pavlidou, V; Olinto, A V; Brown, C; Fields, B D

    2007-01-01

    The third EGRET catalog contains a large number of unidentified sources. Current data allows the intriguing possibility that some of these objects may represent a new class of yet undiscovered gamma-ray sources. By assuming that galaxies similar to the Milky Way host comparable populations of objects, we constrain the allowed Galactic abundance and distribution of various classes of gamma-ray sources using the EGRET data set. Furthermore, regardless of the nature of the unidentified sources, faint unresolved objects of the same class contribute to the observed diffuse gamma-ray background. We investigate the potential contribution of these unresolved sources to the extragalactic gamma-ray background

  18. A case study of IMRT planning (Plan B) subsequent to a previously treated IMRT plan (Plan A)

    International Nuclear Information System (INIS)

    2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Cao, F; 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Leong, C; 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Schroeder, J; 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Lee, B

    2014-01-01

    Background and purpose: Treatment of the contralateral neck after previous ipsilateral intensity modulated radiation therapy (IMRT) for head and neck cancer is a challenging problem. We have developed a technique that limits the cumulative dose to the spinal cord and brainstem while maximizing coverage of a planning target volume (PTV) in the contralateral neck. Our case involves a patient with right tonsil carcinoma who was given ipsilateral IMRT with 70Gy in 35 fractions (Plan A). A left neck recurrence was detected 14 months later. The patient underwent a neck dissection followed by postoperative left neck radiation to a dose of 66 Gy in 33 fractions (Plan B). Materials and Methods: The spinal cord-brainstem margin (SCBM) was defined as the spinal cord and brainstem with a 1.0 cm margin. Plan A was recalculated on the postoperative CT scan but the fluence outside of SCBM was deleted. A further modification of Plan A resulted in a base plan that was summed with Plan B to evaluate the cumulative dose received by the spinal cord and brainstem. Plan B alone was used to evaluate for coverage of the contralateral neck PTV. Results: The maximum cumulative doses to the spinal cord with 0.5cm margin and brainstem with 0.5cm margin were 51.96 Gy and 45.60 Gy respectively. For Plan B, 100% of the prescribed dose covered 95% of PTVb1. Conclusion: The use of a modified ipsilateral IMRT plan as a base plan is an effective way to limit the cumulative dose to the spinal cord and brainstem while enabling coverage of a PTV in the contralateral neck.

  19. Evaluation of a rapid dipstick (Crystal VC for the diagnosis of cholera in Zanzibar and a comparison with previous studies.

    Directory of Open Access Journals (Sweden)

    Benedikt Ley

    Full Text Available The gold standard for the diagnosis of cholera is stool culture, but this requires laboratory facilities and takes at least 24 hours. A rapid diagnostic test (RDT that can be used by minimally trained staff at treatment centers could potentially improve the reporting and management of cholera outbreaks.We evaluated the Crystal VC™ RDT under field conditions in Zanzibar in 2009. Patients presenting to treatment centers with watery diarrhea provided a stool sample for rapid diagnostic testing. Results were compared to stool culture performed in a reference laboratory. We assessed the overall performance of the RDT and evaluated whether previous intake of antibiotics, intravenous fluids, location of testing, and skill level of the technician affected the RDT results.We included stool samples from 624 patients. Compared to culture, the overall sensitivity of the RDT was 93.1% (95%CI: 88.7 to 96.2%, specificity was 49.2% (95%CI: 44.3 to 54.1%, the positive predictive value was 47.0% (95%CI: 42.1 to 52.0% and the negative predictive value was 93.6% (95%CI: 89.6 to 96.5%. The overall false positivity rate was 50.8% (213/419; fieldworkers frequently misread very faint test lines as positive.The observed sensitivity of the Crystal VC RDT evaluated was similar compared to earlier versions, while specificity was poorer. The current version of the RDT could potentially be used as a screening tool in the field. Because of the high proportion of false positive results when field workers test stool specimens, positive results will need to be confirmed with stool culture.

  20. Studies in iodine metabolism: 33 year summary, 1948-1979 (as previously submitted) with appendix, 1979-1982

    International Nuclear Information System (INIS)

    Middlesworth, L.V.

    1982-01-01

    The results of research into iodine metabolism from 1948 to 1982 are summarized. Study areas included the monitoring of iodine 131 from fallout in the thyroid glands of cattle and humans, the biological functions and metabolism of thyroid hormones, and methods to reduce the retention of radioiodine in the thyroid

  1. Neutral beam source commercialization study. Final report

    International Nuclear Information System (INIS)

    King, H.J.

    1980-06-01

    The basic tasks of this Phase II project were to: generate a set of design drawings suitable for quantity production of sources of this design; fabricate a functional neutral beam source incorporating as many of the proposed design changes as proved feasible; and document the procedures and findings developed during the contract. These tasks have been accomplished and represent a demonstrated milestone in the industrialization of this complete device

  2. Studies of the infrared source CRL 2688

    International Nuclear Information System (INIS)

    Ney, E.P.; Merrill, K.M.; Becklin, E.E.; Neugebauer, G.; Wynn-Williams, C.G.

    1975-01-01

    Infrared, optical, and radio observations are descirbed of a newly discovered galactic infrared source. Most of the radiation comes from 1/sup double-prime/./sub /5 diameter infrared source at a temperature of about 150 K, but some visible emission in the form of a symmetrical highly polarized reflection nebulosity is also seen. The object could represent either a very early or a very late stage in stellar evolution

  3. CHRONOVAC VOYAGEUR: A study of the immune response to yellow fever vaccine among infants previously immunized against measles.

    Science.gov (United States)

    Goujon, Catherine; Gougeon, Marie-Lise; Tondeur, Laura; Poirier, Béatrice; Seffer, Valérie; Desprès, Philippe; Consigny, Paul-Henri; Vray, Muriel

    2017-10-27

    For administration of multiple live attenuated vaccines, the Advisory Committee on Immunization Practices recommends either simultaneous immunization or period of at least 28days between vaccines, due to a possible reduction in the immune response to either vaccine. The main objective of this study was to compare the immune response to measles (alone or combined with mumps and rubella) and yellow fever vaccines among infants aged 6-24months living in a yellow fever non-endemic country who had receivedmeasles and yellow fever vaccines before travelling to a yellow fever endemic area. A retrospective, multicenter case-control study was carried out in 7 travel clinics in the Paris area from February 1st 2011 to march 31, 2015. Cases were defined as infants immunized with the yellow fever vaccine and with the measles vaccine, either alone or in combination with mumps and rubella vaccine, with a period of 1-27days between each immunization. For each case, two controls were matched based on sex and age: a first control group (control 1) was defined as infants having received the measles vaccine and the yellow fever vaccine simultaneously; a second control group (control 2) was defined as infants who had a period of more than 27days between receiving the measles vaccine and yellow fever vaccine. The primary endpoint of the study was the percentage of infants with protective immunity against yellow fever, measured by the titer of neutralizing antibodies in a venous blood sample. One hundred and thirty-one infants were included in the study (62 cases, 50 infants in control 1 and 19 infants in control 2). Of these, 127 (96%) were shown to have a protective titer of yellow fever antibodies. All 4 infants without a protective titer of yellow fever antibodies were part of control group 1. The measles vaccine, alone or combined with mumps and rubella vaccines, appears to have no influence on humoral immune response to the yellow fever vaccine when administered between 1 and 27

  4. Structural Study and Evaluation of Previous Restoration Work of Mohammad 'Ali Pasha Mosque at the Citadel in Cairo

    Directory of Open Access Journals (Sweden)

    dr.Yaser Yehya Amin Abdel-Aty

    2011-01-01

    Full Text Available Mohammad 'Ali Pasha Mosque at the Citadel in Cairo is considered one of the main landmarks in Egypt. It majestically stands at a northwestern bend of the Citadel and it is visible from numerous locations in Cairo. It has become the symbol of the Citadel, to the point that its name is given to the whole complex in the colloquial Egyptian parlance. This paper studies analytically the static and dynamic structural behavior of this great mosque using computer numerical modeling techniques, to reach the main reasons for past cracking and failures in its domed-roof and other structural elements, which occurred by the end of 19th Century. A number of 3D-models are analyzed to study the mosque, in both original and after restoration conditions, under static (i.e. dead and live loads and dynamic (i.e. Eigenvector modal analysis, response-spectrum and time-history cases of loading. Besides, structural evaluation of major restoration project, in 1930s, is conducted to determine the current structural safety status of the mosque

  5. Comparative study of a novel application of automated HR HPV assay and stability in a previously untested Preservative media.

    Science.gov (United States)

    Morel, Mike E; McBride, Simon E; Gomez, Maria P

    2017-12-01

    The suitability and stability of cervical cells in Novaprep media (NHQ) for certain HPV assays is unknown. We evaluated the accuracy of an automated HPV assay (Abbott RealTime HR HPV) for cervical cells prepared in NHQ and NHQ with a pre-treatment to mimic a worst case clinical use, compared to the assay manufacturers media; repeatability and reproducibility of HPV results and the stability of detectable HPV in NHQ over time compared to CE marked liquid based cytology preservatives. Cell lines were used to simulate patient samples. Cells stored in NHQ produced accurate, repeatable and reproducible results. Stability in NHQ was comparable to the best performing LBC, with at least 7 months' stability at 18-25°C, 2-8°C, -20°C and -80°C; and at least 3 months' stability at 40°C. Similar results were obtained for pre-treated NHQ except only 3.5 months' stability at 18-25°C. Cell line samples in all media and concentrations tested were detected appropriately by the assay. Based on this first stage validation analytical study, cervical cells stored in NHQ are suitable for the Realtime HPV assay. There should be no reservations for inclusion of NHQ in any further validation and clinical performance evaluation of this assay. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  6. Comparative study of a novel application of automated HR HPV assay and stability in a previously untested Preservative media

    Directory of Open Access Journals (Sweden)

    Mike E. Morel

    2017-12-01

    Full Text Available Background: The suitability and stability of cervical cells in Novaprep media (NHQ for certain HPV assays is unknown. Methods: We evaluated the accuracy of an automated HPV assay (Abbott RealTime HR HPV for cervical cells prepared in NHQ and NHQ with a pre-treatment to mimic a worst case clinical use, compared to the assay manufacturers media; repeatability and reproducibility of HPV results and the stability of detectable HPV in NHQ over time compared to CE marked liquid based cytology preservatives. Cell lines were used to simulate patient samples. Results: Cells stored in NHQ produced accurate, repeatable and reproducible results. Stability in NHQ was comparable to the best performing LBC, with at least 7 months’ stability at 18–25 °C, 2–8 °C, −20 °C and −80 °C; and at least 3 months’ stability at 40 °C. Similar results were obtained for pre-treated NHQ except only 3.5 months’ stability at 18–25 °C. Cell line samples in all media and concentrations tested were detected appropriately by the assay. Conclusions: Based on this first stage validation analytical study, cervical cells stored in NHQ are suitable for the Realtime HPV assay. There should be no reservations for inclusion of NHQ in any further validation and clinical performance evaluation of this assay. Keywords: HPV, Preservative, Sample stability, Automated HR HPV assay

  7. Earthquake source studies and seismic imaging in Alaska

    Science.gov (United States)

    Tape, C.; Silwal, V.

    2015-12-01

    Alaska is one of the world's most seismically and tectonically active regions. Its enhanced seismicity, including slab seismicity down to 180 km, provides opportunities (1) to characterize pervasive crustal faulting and slab deformation through the estimation of moment tensors and (2) to image subsurface structures to help understand the tectonic evolution of Alaska. Most previous studies of earthquakes and seismic imaging in Alaska have emphasized earthquake locations and body-wave travel-time tomography. In the past decade, catalogs of seismic moment tensors have been established, while seismic surface waves, active-source data, and potential field data have been used to improve models of seismic structure. We have developed moment tensor catalogs in the regions of two of the largest sedimentary basins in Alaska: Cook Inlet forearc basin, west of Anchorage, and Nenana basin, west of Fairbanks. Our moment tensor solutions near Nenana basin suggest a transtensional tectonic setting, with the basin developing in a stepover of a left-lateral strike-slip fault system. We explore the effects of seismic wave propagation from point-source and finite-source earthquake models by performing three-dimensional wavefield simulations using seismic velocity models that include major sedimentary basins. We will use our catalog of moment tensors within an adjoint-based, iterative inversion to improve the three-dimensional tomographic model of Alaska.

  8. Reactivity studies on the advanced neutron source

    International Nuclear Information System (INIS)

    Ryskamp, J.M.; Redmond, E.L. II; Fletcher, C.D.

    1990-01-01

    An Advanced Neutron Source (ANS) with a peak thermal neutron flux of about 8.5 x 10 19 m -2 s -1 is being designed for condensed matter physics, materials science, isotope production, and fundamental physics research. The ANS is a new reactor-based research facility being planned by Oak Ridge National Laboratory (ORNL) to meet the need for an intense steady-state source of neutrons. The design effort is currently in the conceptual phase. A reference reactor design has been selected in order to examine the safety, performance, and costs associated with this one design. The ANS Project has an established, documented safety philosophy, and safety-related design criteria are currently being established. The purpose of this paper is to present analyses of safety aspects of the reference reactor design that are related to core reactivity events. These analyses include control rod worth, shutdown rod worth, heavy water voiding, neutron beam tube flooding, light water ingress, and single fuel element criticality. Understanding these safety aspects will allow us to make design modifications that improve the reactor safety and achieve the safety related design criteria. 8 refs., 3 tabs

  9. Studies on the method of producing radiographic 170Tm source

    International Nuclear Information System (INIS)

    Maeda, Sho

    1976-08-01

    A method of producing radiographic 170 Tm source has been studied, including target preparation, neutron irradiation, handling of the irradiated target in the hot cell and source capsules. On the basis of the results, practical 170 Tm radiographic sources (29 -- 49Ci, with pellets 3mm in diameter and 3mm long) were produced in trial by neutron irradiation with the JMTR. (auth.)

  10. Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant.

    Science.gov (United States)

    Persky, Victoria; Piorkowski, Julie; Turyk, Mary; Freels, Sally; Chatterton, Robert; Dimos, John; Bradlow, H Leon; Chary, Lin Kaatz; Burse, Virlyn; Unterman, Terry; Sepkovic, Daniel W; McCann, Kenneth

    2012-08-29

    Studies have shown associations of diabetes and endogenous hormones with exposure to a wide variety of organochlorines. We have previously reported positive associations of polychlorinated biphenyls (PCBs) and inverse associations of selected steroid hormones with diabetes in postmenopausal women previously employed in a capacitor manufacturing plant. This paper examines associations of PCBs with diabetes and endogenous hormones in 63 men previously employed at the same plant who in 1996 underwent surveys of their exposure and medical history and collection of bloods and urine for measurements of PCBs, lipids, liver function, hematologic markers and endogenous hormones. PCB exposure was positively associated with diabetes and age and inversely associated with thyroid stimulating hormone and triiodothyronine-uptake. History of diabetes was significantly related to total PCBs and all PCB functional groupings, but not to quarters worked and job score, after control for potential confounders. None of the exposures were related to insulin resistance (HOMA-IR) in non-diabetic men. Associations of PCBs with specific endogenous hormones differ in some respects from previous findings in postmenopausal women employed at the capacitor plant. Results from this study, however, do confirm previous reports relating PCB exposure to diabetes and suggest that these associations are not mediated by measured endogenous hormones.

  11. Quantifying the influence of previously burned areas on suppression effectiveness and avoided exposure: A case study of the Las Conchas Fire

    Science.gov (United States)

    Matthew P. Thompson; Patrick Freeborn; Jon D. Rieck; Dave Calkin; Julie W. Gilbertson-Day; Mark A. Cochrane; Michael S. Hand

    2016-01-01

    We present a case study of the Las Conchas Fire (2011) to explore the role of previously burned areas (wildfires and prescribed fires) on suppression effectiveness and avoided exposure. Methodological innovations include characterisation of the joint dynamics of fire growth and suppression activities, development of a fire line effectiveness framework, and...

  12. Dosimetric characterization of two radium sources for retrospective dosimetry studies

    Energy Technology Data Exchange (ETDEWEB)

    Candela-Juan, C., E-mail: ccanjuan@gmail.com [Radiation Oncology Department, La Fe University and Polytechnic Hospital, Valencia 46026, Spain and Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100 (Spain); Karlsson, M. [Division of Radiological Sciences, Department of Medical and Health Sciences, Linköping University, Linköping SE 581 85 (Sweden); Lundell, M. [Department of Medical Physics and Oncology, Karolinska University Hospital and Karolinska Institute, Stockholm SE 171 76 (Sweden); Ballester, F. [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100 (Spain); Tedgren, Å. Carlsson [Division of Radiological Sciences, Department of Medical and Health Sciences, Linköping University, Linköping SE 581 85, Sweden and Swedish Radiation Safety Authority, Stockholm SE 171 16 (Sweden)

    2015-05-15

    Purpose: During the first part of the 20th century, {sup 226}Ra was the most used radionuclide for brachytherapy. Retrospective accurate dosimetry, coupled with patient follow up, is important for advancing knowledge on long-term radiation effects. The purpose of this work was to dosimetrically characterize two {sup 226}Ra sources, commonly used in Sweden during the first half of the 20th century, for retrospective dose–effect studies. Methods: An 8 mg {sup 226}Ra tube and a 10 mg {sup 226}Ra needle, used at Radiumhemmet (Karolinska University Hospital, Stockholm, Sweden), from 1925 to the 1960s, were modeled in two independent Monte Carlo (MC) radiation transport codes: GEANT4 and MCNP5. Absorbed dose and collision kerma around the two sources were obtained, from which the TG-43 parameters were derived for the secular equilibrium state. Furthermore, results from this dosimetric formalism were compared with results from a MC simulation with a superficial mould constituted by five needles inside a glass casing, placed over a water phantom, trying to mimic a typical clinical setup. Calculated absorbed doses using the TG-43 formalism were also compared with previously reported measurements and calculations based on the Sievert integral. Finally, the dose rate at large distances from a {sup 226}Ra point-like-source placed in the center of 1 m radius water sphere was calculated with GEANT4. Results: TG-43 parameters [including g{sub L}(r), F(r, θ), Λ, and s{sub K}] have been uploaded in spreadsheets as additional material, and the fitting parameters of a mathematical curve that provides the dose rate between 10 and 60 cm from the source have been provided. Results from TG-43 formalism are consistent within the treatment volume with those of a MC simulation of a typical clinical scenario. Comparisons with reported measurements made with thermoluminescent dosimeters show differences up to 13% along the transverse axis of the radium needle. It has been estimated that

  13. Photoemission studies using laboratory and synchrotron sources

    International Nuclear Information System (INIS)

    Phase, D.M.

    2012-01-01

    Synchrotron radiation sources, providing intense, polarized and stable beams of ultra violet soft and hard X-ray photons, are having great impact on physics, chemistry, biology materials science and other areas research. In particular synchrotron radiation has revolutionized photoelectron spectroscopy by enhancing its capabilities for investigating the electronic properties of solids. The first Indian synchrotron storage ring, Indus- 1 is in operation at RRCAT, Indore. The UGC-DAE CSR with the help of university scientist had designed and developed an angle integrated photoelectron spectroscopy (PES) beamline on this 450 MeV storage ring. A storage ring of this kind is most suitable for investigation in the energy range from few electron volts to around five hundred electron volts. In this lecture we will describe the details of PES beamline and its experimental station. Till date the different university users carried out photoemission measurements on variety of samples. Some of the spectra recorded by users will be presented in order to show the capability of this beamline. In the later part we will report a review of our recent research work carried out on dilute magnetic thin films using this beamline. (author)

  14. PUREX source Aggregate Area management study report

    International Nuclear Information System (INIS)

    1993-03-01

    This report presents the results of an aggregate area management study (AAMS) for the PUREX Plant Aggregate Area in the 200 Areas of the US Department of Energy (DOE)Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past-practice investigations

  15. 42 CFR 456.244 - Data sources for studies.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Data sources for studies. 456.244 Section 456.244 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...: Medical Care Evaluation Studies § 456.244 Data sources for studies. Data that the committee uses to...

  16. 42 CFR 456.144 - Data sources for studies.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Data sources for studies. 456.144 Section 456.144 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Care Evaluation Studies § 456.144 Data sources for studies. Data that the committee uses to perform...

  17. Uncertainty sources in radiopharmaceuticals clinical studies

    International Nuclear Information System (INIS)

    Degenhardt, Aemilie Louize; Oliveira, Silvia Maria Velasques de

    2014-01-01

    The radiopharmaceuticals should be approved for consumption by evaluating their quality, safety and efficacy. Clinical studies are designed to verify the pharmacodynamics, pharmacological and clinical effects in humans and are required for assuring safety and efficacy. The Bayesian analysis has been used for clinical studies effectiveness evaluation. This work aims to identify uncertainties associated with the process of production of the radionuclide and radiopharmaceutical labelling as well as the radiopharmaceutical administration and scintigraphy images acquisition and processing. For the development of clinical studies in the country, the metrological chain shall assure the traceability of the surveys performed in all phases. (author)

  18. A cross-sectional study of tuberculosis drug resistance among previously treated patients in a tertiary hospital in Accra, Ghana: public health implications of standardized regimens.

    Science.gov (United States)

    Forson, Audrey; Kwara, Awewura; Kudzawu, Samuel; Omari, Michael; Otu, Jacob; Gehre, Florian; de Jong, Bouke; Antonio, Martin

    2018-04-02

    Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequency and pattern of drug resistance among previously treated patients with smear-positive pulmonary tuberculosis at the Korle-Bu Teaching Hospital Chest Clinic, Accra. This was a cross-sectional survey of mycobacterial isolates from previously treated patients referred to the Chest Clinic Laboratory between October 2010 and October 2013. The Bactec MGIT 960 system for mycobactrerial culture and drug sensitivity testing (DST) was used for sputum culture of AFB smear-positive patients with relapse, treatment failure, failure of smear conversion, or default. Descriptive statistics were used to summarize patient characteristics, and frequency and patterns of drug resistance. A total of 112 isolates were studied out of 155 from previously treated patients. Twenty contaminated (12.9%) and 23 non-viable isolates (14.8%) were excluded. Of the 112 studied isolates, 53 (47.3%) were pan-sensitive to all first-line drugs tested Any resistance (mono and poly resistance) to isoniazid was found in 44 isolates (39.3%) and any resistance to streptomycin in 43 (38.4%). Thirty-one (27.7%) were MDR-TB. Eleven (35.5%) out of 31 MDR-TB isolates were pre-XDR. MDR-TB isolates were more likely than non-MDR isolates to have streptomycin and ethambutol resistance. The main findings of this study were the high prevalence of MDR-TB and streptomycin resistance among previously treated TB patients, as well as a high prevalence of pre-XDR-TB among the MDR-TB patients, which suggest that first-line and second-line DST is essential to aid the design of effective regimens for these groups of patients in Ghana.

  19. Semiworks source aggregate area management study report

    International Nuclear Information System (INIS)

    1993-05-01

    This report presents the results of an aggregate area management study (AAMS) for the Semi-Works Aggregate Area in the 200 Areas of the US Department of Energy (DOE) . Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations WD and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment storage, or disposal (TSD) closure activities with CERCLA and RCRA past-practice investigations. This approach is described and justified in The Hanford Federal Facility Agreement and Consent Order Change Package. This strategy provides new concepts for: accelerating decision-malting by maximizing the use of existing data consistent with data quality objectives (DQOs); and undertaking expedited response actions (ERAS) and/or interim remedial measures (IRMs), as appropriate, to either remove threats to human health and welfare and the environment, or to reduce risk by reducing toxicity, mobility, or volume of contaminants

  20. Open-Source Data and the Study of Homicide.

    Science.gov (United States)

    Parkin, William S; Gruenewald, Jeff

    2015-07-20

    To date, no discussion has taken place in the social sciences as to the appropriateness of using open-source data to augment, or replace, official data sources in homicide research. The purpose of this article is to examine whether open-source data have the potential to be used as a valid and reliable data source in testing theory and studying homicide. Official and open-source homicide data were collected as a case study in a single jurisdiction over a 1-year period. The data sets were compared to determine whether open-sources could recreate the population of homicides and variable responses collected in official data. Open-source data were able to replicate the population of homicides identified in the official data. Also, for every variable measured, the open-sources captured as much, or more, of the information presented in the official data. Also, variables not available in official data, but potentially useful for testing theory, were identified in open-sources. The results of the case study show that open-source data are potentially as effective as official data in identifying individual- and situational-level characteristics, provide access to variables not found in official homicide data, and offer geographic data that can be used to link macro-level characteristics to homicide events. © The Author(s) 2015.

  1. The Source Inversion Validation (SIV) Initiative: A Collaborative Study on Uncertainty Quantification in Earthquake Source Inversions

    Science.gov (United States)

    Mai, P. M.; Schorlemmer, D.; Page, M.

    2012-04-01

    Earthquake source inversions image the spatio-temporal rupture evolution on one or more fault planes using seismic and/or geodetic data. Such studies are critically important for earthquake seismology in general, and for advancing seismic hazard analysis in particular, as they reveal earthquake source complexity and help (i) to investigate earthquake mechanics; (ii) to develop spontaneous dynamic rupture models; (iii) to build models for generating rupture realizations for ground-motion simulations. In applications (i - iii), the underlying finite-fault source models are regarded as "data" (input information), but their uncertainties are essentially unknown. After all, source models are obtained from solving an inherently ill-posed inverse problem to which many a priori assumptions and uncertain observations are applied. The Source Inversion Validation (SIV) project is a collaborative effort to better understand the variability between rupture models for a single earthquake (as manifested in the finite-source rupture model database) and to develop robust uncertainty quantification for earthquake source inversions. The SIV project highlights the need to develop a long-standing and rigorous testing platform to examine the current state-of-the-art in earthquake source inversion, and to develop and test novel source inversion approaches. We will review the current status of the SIV project, and report the findings and conclusions of the recent workshops. We will briefly discuss several source-inversion methods, how they treat uncertainties in data, and assess the posterior model uncertainty. Case studies include initial forward-modeling tests on Green's function calculations, and inversion results for synthetic data from spontaneous dynamic crack-like strike-slip earthquake on steeply dipping fault, embedded in a layered crustal velocity-density structure.

  2. Is email a reliable means of contacting authors of previously published papers? A study of the Emergency Medicine Journal for 2001.

    Science.gov (United States)

    O'Leary, F

    2003-07-01

    To determine whether it is possible to contact authors of previously published papers via email. A cross sectional study of the Emergency Medicine Journal for 2001. 118 articles were included in the study. The response rate from those with valid email addresses was 73%. There was no statistical difference between the type of email address used and the address being invalid (p=0.392) or between the type of article and the likelihood of a reply (p=0.197). More responses were obtained from work addresses when compared with Hotmail addresses (86% v 57%, p=0.02). Email is a valid means of contacting authors of previously published articles, particularly within the emergency medicine specialty. A work based email address may be a more valid means of contact than a Hotmail address.

  3. Previous dropout from diabetic care as a predictor of patients' willingness to use mobile applications for self-management: A cross-sectional study.

    Science.gov (United States)

    Yamaguchi, Satoko; Waki, Kayo; Tomizawa, Nobuko; Waki, Hironori; Nannya, Yasuhito; Nangaku, Masaomi; Kadowaki, Takashi; Ohe, Kazuhiko

    2017-07-01

    Preventing dropout is crucial in managing diabetes. Accordingly, we investigated whether patients who had dropped out of diabetic care are suitable candidates for the use of mobile technologies - such as smartphone applications - to support self-management (mHealth), which might help prevent dropout. We carried out a cross-sectional study in Tokyo, Japan. Patients aged 20 years or older who were clinically diagnosed as diabetic and who regularly visited the outpatient unit at the University of Tokyo Hospital were recruited between August 2014 and March 2015. Data were collected through face-to-face structured interviews, physical measurements and medical records. Participants were asked whether they were willing to use mHealth after being shown DialBetics - an mHealth application for diabetics - as an example, and about their history of dropout and previous mHealth experience. Data were analyzed by multivariate logistic regression models. Of 307 patients with type 1 and type 2 diabetes, 34 (11.1%) had previously dropped out from diabetic care. Multivariate analysis identified previous mHealth experience as a negative predictor of dropout (odds ratio 0.211, P = 0.023). Of those 34 patients, 27 (79.4%) expressed willingness to use mHealth, a significantly higher percentage than for those who had never dropped out (51.5%, P = 0.002). After adjusting for confounders, history of dropout remained a strong predictor of willingness (odds ratio 3.870, P = 0.004). Patients who previously dropped out of diabetic care are suitable candidates for mHealth. Future studies must evaluate whether mHealth is effective for preventing repeated dropout and improving glycemic control among this population. © 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

  4. Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study

    DEFF Research Database (Denmark)

    Schramm, Tina Ken; Gislason, Gunnar Hilmar; Vaag, Allan

    2011-01-01

    Aims The impact of insulin secretagogues (ISs) on long-term major clinical outcomes in type 2 diabetes remains unclear. We examined mortality and cardiovascular risk associated with all available ISs compared with metformin in a nationwide study. Methods and results All Danish residents >20 years......, initiating single-agent ISs or metformin between 1997 and 2006 were followed for up to 9 years (median 3.3 years) by individual-level linkage of nationwide registers. All-cause mortality, cardiovascular mortality, and the composite of myocardial infarction (MI), stroke, and cardiovascular mortality...... associated with individual ISs were investigated in patients with or without previous MI by multivariable Cox proportional-hazard analyses including propensity analyses. A total of 107 806 subjects were included, of whom 9607 had previous MI. Compared with metformin, glimepiride (hazard ratios and 95...

  5. Sources

    International Nuclear Information System (INIS)

    Duffy, L.P.

    1991-01-01

    This paper discusses the sources of radiation in the narrow perspective of radioactivity and the even narrow perspective of those sources that concern environmental management and restoration activities at DOE facilities, as well as a few related sources. Sources of irritation, Sources of inflammatory jingoism, and Sources of information. First, the sources of irritation fall into three categories: No reliable scientific ombudsman to speak without bias and prejudice for the public good, Technical jargon with unclear definitions exists within the radioactive nomenclature, and Scientific community keeps a low-profile with regard to public information. The next area of personal concern are the sources of inflammation. This include such things as: Plutonium being described as the most dangerous substance known to man, The amount of plutonium required to make a bomb, Talk of transuranic waste containing plutonium and its health affects, TMI-2 and Chernobyl being described as Siamese twins, Inadequate information on low-level disposal sites and current regulatory requirements under 10 CFR 61, Enhanced engineered waste disposal not being presented to the public accurately. Numerous sources of disinformation regarding low level radiation high-level radiation, Elusive nature of the scientific community, The Federal and State Health Agencies resources to address comparative risk, and Regulatory agencies speaking out without the support of the scientific community

  6. NATO Advanced Study Institute on Physics of New Laser Sources

    CERN Document Server

    Arecchi, F; Mooradian, Aram; Sona, Alberto

    1985-01-01

    This volume contains the lectures and seminars presented at the NATO Advanced Study Institute on "Physics of New Laser Sources", the twelfth course of the Europhysics School of Quantum Electronics, held under the supervision of the Quantum Electronics Division of the European Physical Society. The Institute was held at Centro "I Cappuccini" San Miniato, Tuscany, July 11-21, 1984. The Europhysics School of Quantum Electronics was started in 1970 with the aim of providing instruction for young researchers and advanced students already engaged in the area of quantum electronics or for those wishing to switch into this area after working previously in other areas. From the outset, the School has been under the direction of Prof. F. T. Arecchi, then at the University of Pavia, now at the University of Florence, and Dr. D. Roess of Heraeus, Hanau. In 1981, Prof. H. Walther, University of Munich and Max-Planck Institut fur Quantenoptik joined as co-director. Each year the Directors choose a subj~ct of particular int...

  7. Acceleration and Orientation Jumping Performance Differences Among Elite Professional Male Handball Players With or Without Previous ACL Reconstruction: An Inertial Sensor Unit-Based Study.

    Science.gov (United States)

    Setuain, Igor; González-Izal, Miriam; Alfaro, Jesús; Gorostiaga, Esteban; Izquierdo, Mikel

    2015-12-01

    Handball is one of the most challenging sports for the knee joint. Persistent biomechanical and jumping capacity alterations can be observed in athletes with an anterior cruciate ligament (ACL) injury. Commonly identified jumping biomechanical alterations have been described by the use of laboratory technologies. However, portable and easy-to-handle technologies that enable an evaluation of jumping biomechanics at the training field are lacking. To analyze unilateral/bilateral acceleration and orientation jumping performance differences among elite male handball athletes with or without previous ACL reconstruction via a single inertial sensor unit device. Case control descriptive study. At the athletes' usual training court. Twenty-two elite male (6 ACL-reconstructed and 16 uninjured control players) handball players were evaluated. The participants performed a vertical jump test battery that included a 50-cm vertical bilateral drop jump, a 20-cm vertical unilateral drop jump, and vertical unilateral countermovement jump maneuvers. Peak 3-dimensional (X, Y, Z) acceleration (m·s(-2)), jump phase duration and 3-dimensional orientation values (°) were obtained from the inertial sensor unit device. Two-tailed t-tests and a one-way analysis of variance were performed to compare means. The P value cut-off for significance was set at P handball athletes with previous ACL reconstruction demonstrated a jumping biomechanical profile similar to control players, including similar jumping performance values in both bilateral and unilateral jumping maneuvers, several years after ACL reconstruction. These findings are in agreement with previous research showing full functional restoration of abilities in top-level male athletes after ACL reconstruction, rehabilitation and subsequent return to sports at the previous level. Copyright © 2015 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

  8. De novo adamantinomatous craniopharyngioma presenting anew in an elderly patient with previous normal CT and MRI studies: A case report and implications on pathogenesis

    Directory of Open Access Journals (Sweden)

    Amy Walker, B.S.

    2015-09-01

    Full Text Available Adamantinomatous craniopharyngiomas are histologically benign epithelial tumors which arise from embryonic remnants of the craniopharyngeal duct and Rathke’s pouch. They are thought to have a congenital origin and are histologically unique from papillary craniopharyngioma. We describe the case of an elderly male who presented with symptoms related to a large craniopharyngioma with previously normal brain magnetic resonance and computed tomography imaging studies. These findings dispute the embryogenic theory that craniopharyngiomas observed in adults develop from the persistent slow growth of embryonic remnants.

  9. Aging affects the interaction between attentional control and source memory: an fMRI study.

    Science.gov (United States)

    Dulas, Michael R; Duarte, Audrey

    2014-12-01

    Age-related source memory impairments may be due, at least in part, to deficits in executive processes mediated by the PFC at both study and test. Behavioral work suggests that providing environmental support at encoding, such as directing attention toward item-source associations, may improve source memory and reduce age-related deficits in the recruitment of these executive processes. The present fMRI study investigated the effects of directed attention and aging on source memory encoding and retrieval. At study, participants were shown pictures of objects. They were either asked to attend to the objects and their color (source) or to their size. At test, participants determined if objects were seen before, and if so, whether they were the same color as previously. Behavioral results showed that direction of attention improved source memory for both groups; however, age-related deficits persisted. fMRI results revealed that, across groups, direction of attention facilitated medial temporal lobe-mediated contextual binding processes during study and attenuated right PFC postretrieval monitoring effects at test. However, persistent age-related source memory deficits may be related to increased recruitment of medial anterior PFC during encoding, indicative of self-referential processing, as well as underrecruitment of lateral anterior PFC-mediated relational processes. Taken together, this study suggests that, even when supported, older adults may fail to selectively encode goal-relevant contextual details supporting source memory performance.

  10. Emotion impairs extrinsic source memory--An ERP study.

    Science.gov (United States)

    Mao, Xinrui; You, Yuqi; Li, Wen; Guo, Chunyan

    2015-09-01

    Substantial advancements in understanding emotional modulation of item memory notwithstanding, controversies remain as to how emotion influences source memory. Using an emotional extrinsic source memory paradigm combined with remember/know judgments and two key event-related potentials (ERPs)-the FN400 (a frontal potential at 300-500 ms related to familiarity) and the LPC (a later parietal potential at 500-700 ms related to recollection), our research investigated the impact of emotion on extrinsic source memory and the underlying processes. We varied a semantic prompt (either "people" or "scene") preceding a study item to manipulate the extrinsic source. Behavioral data indicated a significant effect of emotion on "remember" responses to extrinsic source details, suggesting impaired recollection-based source memory in emotional (both positive and negative) relative to neutral conditions. In parallel, differential FN400 and LPC amplitudes (correctly remembered - incorrectly remembered sources) revealed emotion-related interference, suggesting impaired familiarity and recollection memory of extrinsic sources associated with positive or negative items. These findings thus lend support to the notion of emotion-induced memory trade off: while enhancing memory of central items and intrinsic/integral source details, emotion nevertheless disrupts memory of peripheral contextual details, potentially impairing both familiarity and recollection. Importantly, that positive and negative items result in comparable memory impairment suggests that arousal (vs. affective valence) plays a critical role in modulating dynamic interactions among automatic and elaborate processes involved in memory. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Impact of Availability and Use of ART/PMTCT Services on Fertility Desires of Previously Pregnant Women in Rakai, Uganda: A Retrospective Cohort Study.

    Science.gov (United States)

    Litwin, Lindsay E; Makumbi, Frederick E; Gray, Ronald; Wawer, Maria; Kigozi, Godfrey; Kagaayi, Joseph; Nakigozi, Gertrude; Lutalo, Tom; Serwada, David; Brahmbhatt, Heena

    2015-07-01

    To assess fertility desires by availability and use of antiretroviral therapy and prevention of mother-to-child transmission (ART/PMTCT) services in Rakai, Uganda. Retrospective analyses of longitudinal data from the Rakai Community Cohort Study. Study participants were retrospectively identified and categorized by HIV status. Availability of ART/PMTCT services in Rakai was defined in three periods: (1) pre-ART/PMTCT (ART/PMTCT rollout (2005-2006), and (3) universal ART/PMTCT (>2006); and use of ART/PMTCT was coded as yes if the woman received services. Trends in fertility desires were assessed by χ. "Modified" Poisson regression was performed using generalized linear models with a log link and Poisson family to estimate prevalence rate ratios (PRRs) and 95% confidence intervals (CIs) of desire for another child among previously and currently pregnant women; PRRs were adjusted for demographic and behavioral factors. A total of 4227 sexually active women in Rakai, including 436 HIV+ women, contributed 13,970 observations over 5 survey rounds. Fertility desires increased in the population in the ART/PMTCT rollout [adjusted (adj.) PRR: 1.08, 95% CI: 1.04 to 1.13] and the universal availability periods (adj. PRR: 1.11, 95% CI: 1.08 to 1.14) compared with pre-ART/PMTCT period. A total of 862 woman observations used ART/PMTCT services. Fertility desires were similar among ART/PMTCT service users and nonusers in cross-sectional analysis (adj. PRR: 0.84, 95% CI: 0.62 to 1.14) and 1 year after ART/PMTCT use (adj. PRR: 1.27, 95% CI: 0.83 to 1.94). Availability of ART/PMTCT may increase fertility desires of previously pregnant women in Rakai, Uganda. Use of ART/PMTCT services was not correlated with fertility desires of previously or current pregnant women.

  12. Engagement as a source of positive consumer behaviour: a study ...

    African Journals Online (AJOL)

    Engagement as a source of positive consumer behaviour: a study amongst South African football fans. ... Remember me ... Further, the potential of fan engagement as a predictor of positive consumer behaviours (match attendance and ...

  13. Emittance studies of the 2.45 GHz permanent magnet ECR ion source

    Science.gov (United States)

    Zelenak, A.; Bogomolov, S. L.; Yazvitsky, N. Yu.

    2004-05-01

    During the past several years different types of permanent magnet 2.45 GHz (electron cyclotron resonance) ion sources were developed for production of singly charged ions. Ion sources of this type are used in the first stage of DRIBs project, and are planned to be used in the MASHA mass separator. The emittance of the beam provided by the source is one of the important parameters for these applications. An emittance scanner composed from a set of parallel slits and rotary wire beam profile monitor was used for the studying of the beam emittance characteristics. The emittance of helium and argon ion beams was measured with different shapes of the plasma electrode for several ion source parameters: microwave power, source potential, plasma aperture-puller aperture gap distance, gas pressure. The results of measurements are compared with previous simulations of ion optics.

  14. Emittance studies of the 2.45 GHz permanent magnet ECR ion source

    International Nuclear Information System (INIS)

    Zelenak, A.; Bogomolov, S.L.; Yazvitsky, N.Yu.

    2004-01-01

    During the past several years different types of permanent magnet 2.45 GHz (electron cyclotron resonance) ion sources were developed for production of singly charged ions. Ion sources of this type are used in the first stage of DRIBs project, and are planned to be used in the MASHA mass separator. The emittance of the beam provided by the source is one of the important parameters for these applications. An emittance scanner composed from a set of parallel slits and rotary wire beam profile monitor was used for the studying of the beam emittance characteristics. The emittance of helium and argon ion beams was measured with different shapes of the plasma electrode for several ion source parameters: microwave power, source potential, plasma aperture-puller aperture gap distance, gas pressure. The results of measurements are compared with previous simulations of ion optics

  15. Outcome of secondary high-grade glioma in children previously treated for a malignant condition: A study of the Canadian Pediatric Brain Tumour Consortium

    International Nuclear Information System (INIS)

    Carret, Anne-Sophie; Tabori, Uri; Crooks, Bruce; Hukin, Juliette; Odame, Isaac; Johnston, Donna L.; Keene, Daniel L.; Freeman, Carolyn; Bouffet, Eric

    2006-01-01

    Background and purpose: Reports of secondary high-grade glioma (HGG) in survivors of childhood cancer are scarce. The aim of this study was to review the pattern of diagnosis, the treatment, and outcome of secondary pediatric HGG. Patients and methods: We performed a multi-center retrospective study among the 17 paediatric institutions participating in the Canadian Pediatric Brain Tumour Consortium (CPBTC). Results: We report on 18 patients (14 males, 4 females) treated in childhood for a primary cancer, who subsequently developed a HGG as a second malignancy. All patients had previously received radiation therapy +/- chemotherapy for either acute lymphoblastic leukaemia (n = 9) or solid tumour (n = 9). All HGG occurred within the previous radiation fields. At the last follow-up, 17 patients have died and the median survival time is 9.75 months. Conclusion: Although aggressive treatment seems to provide sustained remissions in some patients, the optimal management is still to be defined. Further documentation of such cases is necessary in order to better understand the pathogenesis, the natural history and the prevention of these tumours

  16. Thermal-hydraulic studies of the Advanced Neutron Source cold source

    International Nuclear Information System (INIS)

    Williams, P.T.; Lucas, A.T.

    1995-08-01

    The Advanced Neutron Source (ANS), in its conceptual design phase at Oak Ridge National Laboratory, was to be a user-oriented neutron research facility producing the most intense steady-state flux of thermal and cold neutrons in the world. Among its many scientific applications, the production of cold neutrons was a significant research mission for the ANS. The cold neutrons come from two independent cold sources positioned near the reactor core. Contained by an aluminum alloy vessel, each cold source is a 410-mm-diam sphere of liquid deuterium that functions both as a neutron moderator and a cryogenic coolant. With nuclear heating of the containment vessel and internal baffling, steady-state operation requires close control of the liquid deuterium flow near the vessel's inner surface. Preliminary thermal-hydraulic analyses supporting the cold source design were performed with heat conduction simulations of the vessel walls and multidimensional computational fluid dynamics simulations of the liquid deuterium flow and heat transfer. This report presents the starting phase of a challenging program and describes the cold source conceptual design, the thermal-hydraulic feasibility studies of the containment vessel, and the future computational and experimental studies that were planned to verify the final design

  17. Studies and modeling of cold neutron sources; Etude et modelisation des sources froides de neutron

    Energy Technology Data Exchange (ETDEWEB)

    Campioni, G

    2004-11-15

    With the purpose of updating knowledge in the fields of cold neutron sources, the work of this thesis has been run according to the 3 following axes. First, the gathering of specific information forming the materials of this work. This set of knowledge covers the following fields: cold neutron, cross-sections for the different cold moderators, flux slowing down, different measurements of the cold flux and finally, issues in the thermal analysis of the problem. Secondly, the study and development of suitable computation tools. After an analysis of the problem, several tools have been planed, implemented and tested in the 3-dimensional radiation transport code Tripoli-4. In particular, a module of uncoupling, integrated in the official version of Tripoli-4, can perform Monte-Carlo parametric studies with a spare factor of Cpu time fetching 50 times. A module of coupling, simulating neutron guides, has also been developed and implemented in the Monte-Carlo code McStas. Thirdly, achieving a complete study for the validation of the installed calculation chain. These studies focus on 3 cold sources currently functioning: SP1 from Orphee reactor and 2 other sources (SFH and SFV) from the HFR at the Laue Langevin Institute. These studies give examples of problems and methods for the design of future cold sources.

  18. Materials compatibility studies for the Spallation Neutron Source

    International Nuclear Information System (INIS)

    DiStefano, J.R.; Pawel, S.J.; Manneschmidt, E.T.

    1998-01-01

    The Spallation Neutron Source (SNS) is a high power facility for producing neutrons that utilizes flowing liquid mercury inside an austenitic stainless steel container as the target for a 1.0 GeV proton beam. Type 316 SS has been selected as the container material for the mercury and consequences of exposure of 316 SS to radiation, thermal shock, thermal stress, cavitation and hot, flowing mercury are all being addressed by R and D programs. In addition, corrosion studies also include evaluation of Inconel 718 because it has been successfully used in previous spallation neutron systems as a window material. Two types of compatibility issues relative to 316 SS/mercury and Inconel 718/mercury are being examined: (1) liquid metal embrittlement (LME) and (2) temperature gradient mass transfer. Studies have shown that mercury does not easily wet type 316 SS below 275 C. In the LME experiments, attempts were made to promote wetting of the steel by mercury either by adding gallium to the mercury or coating the specimen with a tin-silver solder that the mercury easily wets. The latter proved more reliable in establishing wetting, but there was no evidence of LME in any of the constant extension rate tensile tests either at 23 or 100 C. Inconel 718 also showed no change in room temperature properties when tested in mercury or mercury-gallium. However, there was evidence that the fracture was less ductile. Preliminary evaluation of mass transfer of either type 316 SS or Inconel 718 in mercury or mercury-gallium at 350 C (maximum temperature) did not reveal significant effects. Two 5,000 h thermal convection loop tests of type 316 SS are in progress, with specimens in both hot and cold test regions, at 300 and 240 C, respectively

  19. Experimental study of adsorption chiller driven by variable heat source

    Energy Technology Data Exchange (ETDEWEB)

    Wang, D.C.; Wang, Y.J.; Zhang, J.P.; Tian, X.L. [College of Electromechanical Engineering, Qingdao University, Qingdao 266071 (China); Wu, J.Y. [Institute of Refrigeration and Cryogenics, Shanghai Jiao Tong University, Shanghai 200030 (China)

    2008-05-15

    A silica gel-water adsorption chiller has been developed in recent years and has been applied in an air conditioning system driven by solar energy. The heat source used to drive the adsorption chiller is variable at any moment because the solar radiation intensity or the waste heat from engines varies frequently. An adsorption cooling system may be badly impacted by a variable heat source with temperature variations in a large range. In this work, a silica gel-water adsorption chiller driven by a variable heat source is experimentally studied. The influences of the variable heat source on the performance of the chiller are analyzed, especially for a continuous temperature increase process and a continuous temperature decrease process of the heat source. As an example, the dynamic characteristics of the heat source are also analyzed when solar energy is taken as the heat source of the adsorption chiller. According to the experimental results for the adsorption chiller and the characteristics of the heat source from solar energy, control strategies of the adsorption chiller driven by solar energy are proposed. (author)

  20. Experimental study of adsorption chiller driven by variable heat source

    International Nuclear Information System (INIS)

    Wang, D.C.; Wang, Y.J.; Zhang, J.P.; Tian, X.L.; Wu, J.Y.

    2008-01-01

    A silica gel-water adsorption chiller has been developed in recent years and has been applied in an air conditioning system driven by solar energy. The heat source used to drive the adsorption chiller is variable at any moment because the solar radiation intensity or the waste heat from engines varies frequently. An adsorption cooling system may be badly impacted by a variable heat source with temperature variations in a large range. In this work, a silica gel-water adsorption chiller driven by a variable heat source is experimentally studied. The influences of the variable heat source on the performance of the chiller are analyzed, especially for a continuous temperature increase process and a continuous temperature decrease process of the heat source. As an example, the dynamic characteristics of the heat source are also analyzed when solar energy is taken as the heat source of the adsorption chiller. According to the experimental results for the adsorption chiller and the characteristics of the heat source from solar energy, control strategies of the adsorption chiller driven by solar energy are proposed

  1. Vitamin D deficiency in medical patients at a central hospital in Malawi: a comparison with TB patients from a previous study.

    Directory of Open Access Journals (Sweden)

    Yamikani Mastala

    Full Text Available OBJECTIVES: To determine the prevalence of vitamin D deficiency (VDD in adult medical, non-tuberculous (non-TB patients. To investigate associations with VDD. To compare the results with a similar study in TB patients at the same hospital. DESIGN: Cross-sectional sample. SETTING: Central hospital in Malawi. PARTICIPANTS: Adult non-TB patients (n = 157, inpatients and outpatients. OUTCOME MEASURES: The primary outcome was the prevalence of VDD. Potentially causal associations sought included nutritional status, in/outpatient status, HIV status, anti-retroviral therapy (ART and, by comparison with a previous study, a diagnosis of tuberculosis (TB. RESULTS: Hypovitaminosis D (≤75 nmol/L occurred in 47.8% (75/157 of patients, 16.6% (26/157 of whom had VDD (≤50 nmol/L. None had severe VDD (≤25 nmol/L. VDD was found in 22.8% (23/101 of in-patients and 5.4% (3/56 of out-patients. In univariable analysis in-patient status, ART use and low dietary vitamin D were significant predictors of VDD. VDD was less prevalent than in previously studied TB patients in the same hospital (68/161 = 42%. In multivariate analysis of the combined data set from both studies, having TB (OR 3.61, 95%CI 2.02-6.43 and being an in-patient (OR 2.70, 95%CI 1.46-5.01 were significant independent predictors of VDD. CONCLUSIONS: About half of adult medical patients without TB have suboptimal vitamin D status, which is more common in in-patients. VDD is much more common in TB patients than non-TB patients, even when other variables are controlled for, suggesting that vitamin D deficiency is associated with TB.

  2. Plantar pressure in diabetic peripheral neuropathy patients with active foot ulceration, previous ulceration and no history of ulceration: a meta-analysis of observational studies.

    Science.gov (United States)

    Fernando, Malindu Eranga; Crowther, Robert George; Pappas, Elise; Lazzarini, Peter Anthony; Cunningham, Margaret; Sangla, Kunwarjit Singh; Buttner, Petra; Golledge, Jonathan

    2014-01-01

    Elevated dynamic plantar pressures are a consistent finding in diabetes patients with peripheral neuropathy with implications for plantar foot ulceration. This meta-analysis aimed to compare the plantar pressures of diabetes patients that had peripheral neuropathy and those with neuropathy with active or previous foot ulcers. Published articles were identified from Medline via OVID, CINAHL, SCOPUS, INFORMIT, Cochrane Central EMBASE via OVID and Web of Science via ISI Web of Knowledge bibliographic databases. Observational studies reporting barefoot dynamic plantar pressure in adults with diabetic peripheral neuropathy, where at least one group had a history of plantar foot ulcers were included. Interventional studies, shod plantar pressure studies and studies not published in English were excluded. Overall mean peak plantar pressure (MPP) and pressure time integral (PTI) were primary outcomes. The six secondary outcomes were MPP and PTI at the rear foot, mid foot and fore foot. The protocol of the meta-analysis was published with PROPSERO, (registration number CRD42013004310). Eight observational studies were included. Overall MPP and PTI were greater in diabetic peripheral neuropathy patients with foot ulceration compared to those without ulceration (standardised mean difference 0.551, 95% CI 0.290-0.811, pdiabetic peripheral neuropathy with a history of foot ulceration compared to those with diabetic neuropathy without a history of ulceration. More homogenous data is needed to confirm these findings.

  3. Comparative studies of energy sources in gynecologic laparoscopy.

    Science.gov (United States)

    Law, Kenneth S K; Lyons, Stephen D

    2013-01-01

    Energy sources incorporating "vessel sealing" capabilities are being increasingly used in gynecologic laparoscopic surgery although conventional monopolar and bipolar electrosurgery remain popular. The preference for one device over another is based on a combination of factors, including the surgeon's subjective experience, availability, and cost. Although comparative clinical studies and meta-analyses of laparoscopic energy sources have reported small but statistically significant differences in volumes of blood loss, the clinical significance of such small volumes is questionable. The overall usefulness of the various energy sources available will depend on a number of factors including vessel burst pressure and seal time, lateral thermal spread, and smoke production. Animal studies and laboratory-based trials are useful in providing a controlled environment to investigate such parameters. At present, there is insufficient evidence to support the use of one energy source over another. Copyright © 2013 AAGL. All rights reserved.

  4. Phase II study of a 3-day schedule with topotecan and cisplatin in patients with previously untreated small cell lung cancer and extensive disease

    DEFF Research Database (Denmark)

    Sorensen, M.; Lassen, Ulrik Niels; Jensen, Peter Buhl

    2008-01-01

    INTRODUCTION: Treatment with a topoisomerase I inhibitor in combination with a platinum results in superior or equal survival compared with etoposide-based treatment in extensive disease small cell lung cancer (SCLC). Five-day topotecan is inconvenient and therefore shorter schedules of topotecan...... and cisplatin are needed. The aim of this phase II study was to establish the response rate and response duration in chemo-naive patients with SCLC receiving a 3-day topotecan and cisplatin schedule. METHODS: Simons optimal two-stage design was used. Patients with previously untreated extensive disease SCLC...... age was 59 (range 44-74), 79% had performance status 0 or 1. Thirty-one patients completed all six cycles. Grade 3/4 anemia, neutrocytopenia, and thrombocytopenia were recorded in 9.5%, 66.7%, and 21.4% of patients, respectively. Fourteen percent of patients experienced neutropenic fever. No episodes...

  5. Earthquake Source Spectral Study beyond the Omega-Square Model

    Science.gov (United States)

    Uchide, T.; Imanishi, K.

    2017-12-01

    Earthquake source spectra have been used for characterizing earthquake source processes quantitatively and, at the same time, simply, so that we can analyze the source spectra for many earthquakes, especially for small earthquakes, at once and compare them each other. A standard model for the source spectra is the omega-square model, which has the flat spectrum and the falloff inversely proportional to the square of frequencies at low and high frequencies, respectively, which are bordered by a corner frequency. The corner frequency has often been converted to the stress drop under the assumption of circular crack models. However, recent studies claimed the existence of another corner frequency [Denolle and Shearer, 2016; Uchide and Imanishi, 2016] thanks to the recent development of seismic networks. We have found that many earthquakes in areas other than the area studied by Uchide and Imanishi [2016] also have source spectra deviating from the omega-square model. Another part of the earthquake spectra we now focus on is the falloff rate at high frequencies, which will affect the seismic energy estimation [e.g., Hirano and Yagi, 2017]. In June, 2016, we deployed seven velocity seismometers in the northern Ibaraki prefecture, where the shallow crustal seismicity mainly with normal-faulting events was activated by the 2011 Tohoku-oki earthquake. We have recorded seismograms at 1000 samples per second and at a short distance from the source, so that we can investigate the high-frequency components of the earthquake source spectra. Although we are still in the stage of discovery and confirmation of the deviation from the standard omega-square model, the update of the earthquake source spectrum model will help us systematically extract more information on the earthquake source process.

  6. EXPERIMENTAL CHALLENGE STUDY OF FV3-LIKE RANAVIRUS INFECTION IN PREVIOUSLY FV3-LIKE RANAVIRUS INFECTED EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA) TO ASSESS INFECTION AND SURVIVAL.

    Science.gov (United States)

    Hausmann, Jennifer C; Wack, Allison N; Allender, Matthew C; Cranfield, Mike R; Murphy, Kevin J; Barrett, Kevin; Romero, Jennell L; Wellehan, James F X; Blum, Stella A; Zink, M Christine; Bronson, Ellen

    2015-12-01

    The Maryland Zoo in Baltimore experienced an outbreak of Frog virus-3 (FV3)-like ranavirus during the summer of 2011, during which 14 of 27 (52%) of its captive eastern box turtles (Terrapene carolina carolina) survived. To assess survival, immunity, and viral shedding, an experimental challenge study was performed in which the surviving, previously infected turtles were reinfected with the outbreak strain of FV3-like ranavirus. Seven turtles were inoculated with virus intramuscularly and four control turtles received saline intramuscularly. The turtles were monitored for 8 wk with blood and oral swabs collected for quantitative polymerase chain reaction (qPCR). During that time, one of seven (14%) inoculated turtles and none of the controls (0%) died; there was no significant difference in survival. Clinical signs of the inoculated turtles, except for the turtle that died, were mild compared to the original outbreak. Quantitative PCR for FV3-like ranavirus on blood and oral swabs was positive for all inoculated turtles and negative for all controls. The turtle that died had intracytoplasmic inclusion bodies in multiple organs. Three inoculated and two control turtles were euthanized at the end of the study. No inclusion bodies were present in any of the organs. Quantitative PCR detected FV3-like ranavirus in the spleen of a control turtle, which suggested persistence of the virus. The surviving five turtles were qPCR-negative for FV3-like ranavirus from blood and oral swabs after brumation. Quantitative PCR for Terrapene herpesvirus 1 found no association between ranavirus infection and herpesvirus loads. In conclusion, previously infected eastern box turtles can be reinfected with the same strain of FV3-like ranavirus and show mild to no clinical signs but can shed the virus from the oral cavity.

  7. Trial of labour and vaginal birth after previous caesarean section: A population based study of Eastern African immigrants in Victoria, Australia.

    Science.gov (United States)

    Belihu, Fetene B; Small, Rhonda; Davey, Mary-Ann

    2017-03-01

    Variations in caesarean section (CS) between some immigrant groups and receiving country populations have been widely reported. Often, African immigrant women are at higher risk of CS than the receiving population in developed countries. However, evidence about subsequent mode of birth following CS for African women post-migration is lacking. The objective of this study was to examine differences in attempted and successful vaginal birth after previous caesarean (VBAC) for Eastern African immigrants (Eritrea, Ethiopia, Somalia and Sudan) compared with Australian-born women. A population-based observational study was conducted using the Victorian Perinatal Data Collection. Pearson's chi-square test and logistic regression analysis were performed to generate adjusted odds ratios for attempted and successful VBAC. Victoria, Australia. 554 Eastern African immigrants and 24,587 Australian-born eligible women with previous CS having singleton births in public care. 41.5% of Eastern African immigrant women and 26.1% Australian-born women attempted a VBAC with 50.9% of Eastern African immigrants and 60.5% of Australian-born women being successful. After adjusting for maternal demographic characteristics and available clinical confounding factors, Eastern African immigrants were more likely to attempt (OR adj 1.94, 95% CI 1.57-2.47) but less likely to succeed (OR adj 0.54 95% CI 0.41-0.71) in having a VBAC. There are disparities in attempted and successful VBAC between Eastern African origin and Australian-born women. Unsuccessful VBAC attempt is more common among Eastern African immigrants, suggesting the need for improved strategies to select and support potential candidates for vaginal birth among these immigrants to enhance success and reduce potential complications associated with failed VBAC attempt. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  8. Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer

    International Nuclear Information System (INIS)

    Arcaroli, John; Quackenbush, Kevin; Dasari, Arvind; Powell, Rebecca; McManus, Martine; Tan, Aik-Choon; Foster, Nathan R; Picus, Joel; Wright, John; Nallapareddy, Sujatha; Erlichman, Charles; Hidalgo, Manuel; Messersmith, Wells A

    2012-01-01

    Src tyrosine kinases are overexpressed in pancreatic cancers, and the oral Src inhibitor saracatinib has shown antitumor activity in preclinical models of pancreas cancer. We performed a CTEP-sponsored Phase II clinical trial of saracatinib in previously treated pancreas cancer patients, with a primary endpoint of 6-month survival. A Simon MinMax two-stage phase II design was used. Saracatinib (175 mg/day) was administered orally continuously in 28-day cycles. In the unselected portion of the study, 18 patients were evaluable. Only two (11%) patients survived for at least 6 months, and three 6-month survivors were required to move to second stage of study as originally designed. The study was amended as a biomarker-driven trial (leucine rich repeat containing protein 19 [LRRC19] > insulin-like growth factor-binding protein 2 [IGFBP2] “top scoring pairs” polymerase chain reaction [PCR] assay, and PIK3CA mutant) based on preclinical data in a human pancreas tumor explant model. In the biomarker study, archival tumor tissue or fresh tumor biopsies were tested. Biomarker-positive patients were eligible for the study. Only one patient was PIK3CA mutant in a 3′ untranslated region (UTR) portion of the gene. This patient was enrolled in the study and failed to meet the 6-month survival endpoint. As the frequency of biomarker-positive patients was very low (<3%), the study was closed. Although we were unable to conclude whether enriching for a subset of second/third line pancreatic cancer patients treated with a Src inhibitor based on a biomarker would improve 6-month survival, we demonstrate that testing pancreatic tumor samples for a biomarker-driven, multicenter study in metastatic pancreas cancer is feasible

  9. PM10 source apportionment study in Pleasant Valley, Nevada

    International Nuclear Information System (INIS)

    Egami, R.T.; Chow, J.C.; Watson, J.G.; DeLong, T.

    1990-01-01

    A source apportionment study was conducted between March 18 and April 4, 1988, at Pleasant Valley, Nevada, to evaluate air pollutant concentrations to which community residents were exposed and the source contributions to those pollutants. Daily PM 10 samples were taken for chemical speciation of 40 trace elements, ions, and organic and elemental carbon. This paper reports that the objectives of this case study are: to determine the emissions source composition of the potential upwind source, a geothermal plant; to measure the ambient particulate concentration and its chemical characteristics in Pleasant Valley; and to estimate the contributions of different emissions sources to PM 10 . The study found that: particulate emissions from the geothermal cooling-tower plume consisted primarily of sulfate, ammonia, chloride, and trace elements; no significant quantities of toxic inorganic species were found in the ambient air; ambient PM 10 concentrations in Pleasant Valley were within Federal standards; and source contribution to PM 10 were approximately 60% geological material; 20% motor vehicle exhaust; and 10% cooling-tower plume

  10. Women's decision-making processes and the influences on their mode of birth following a previous caesarean section in Taiwan: a qualitative study.

    Science.gov (United States)

    Chen, Shu-Wen; Hutchinson, Alison M; Nagle, Cate; Bucknall, Tracey K

    2018-01-17

    Vaginal birth after caesarean (VBAC) is an alternative option for women who have had a previous caesarean section (CS); however, uptake is limited because of concern about the risks of uterine rupture. The aim of this study was to explore women's decision-making processes and the influences on their mode of birth following a previous CS. A qualitative approach was used. The research comprised three stages. Stage I consisted of naturalistic observation at 33-34 weeks' gestation. Stage II involved interviews with pregnant women at 35-37 weeks' gestation. Stage III consisted of interviews with the same women who were interviewed postnatally, 1 month after birth. The research was conducted in a private medical centre in northern Taiwan. Using a purposive sampling, 21 women and 9 obstetricians were recruited. Data collection involved in-depth interviews, observation and field notes. Constant comparative analysis was employed for data analysis. Ensuring the safety of mother and baby was the focus of women's decisions. Women's decisions-making influences included previous birth experience, concern about the risks of vaginal birth, evaluation of mode of birth, current pregnancy situation, information resources and health insurance. In communicating with obstetricians, some women complied with obstetricians' recommendations for repeat caesarean section (RCS) without being informed of alternatives. Others used four step decision-making processes that included searching for information, listening to obstetricians' professional judgement, evaluating alternatives, and making a decision regarding mode of birth. After birth, women reflected on their decisions in three aspects: reflection on birth choices; reflection on factors influencing decisions; and reflection on outcomes of decisions. The health and wellbeing of mother and baby were the major concerns for women. In response to the decision-making influences, women's interactions with obstetricians regarding birth choices

  11. Simulation study on ion extraction from ECR ion sources

    International Nuclear Information System (INIS)

    Fu, S.; Kitagawa, A.; Yamada, S.

    1993-07-01

    In order to study beam optics of NIRS-ECR ion source used in HIMAC, EGUN code has been modified to make it capable of modeling ion extraction from a plasma. Two versions of the modified code are worked out with two different methods in which 1-D and 2-D sheath theories are used respectively. Convergence problem of the strong nonlinear self-consistent equations is investigated. Simulations on NIRS-ECR ion source and HYPER-ECR ion source (in INS, Univ. of Tokyo) are presented in this paper, exhibiting an agreement with the experimental results. Some preliminary suggestions on the upgrading the extraction systems of these sources are also proposed. (author)

  12. Simulation study on ion extraction from ECR ion sources

    Energy Technology Data Exchange (ETDEWEB)

    Fu, S.; Kitagawa, A.; Yamada, S.

    1993-07-01

    In order to study beam optics of NIRS-ECR ion source used in HIMAC, EGUN code has been modified to make it capable of modeling ion extraction from a plasma. Two versions of the modified code are worked out with two different methods in which 1-D and 2-D sheath theories are used respectively. Convergence problem of the strong nonlinear self-consistent equations is investigated. Simulations on NIRS-ECR ion source and HYPER-ECR ion source (in INS, Univ. of Tokyo) are presented in this paper, exhibiting an agreement with the experimental results. Some preliminary suggestions on the upgrading the extraction systems of these sources are also proposed. (author).

  13. Photon activation therapy: a Monte Carlo study on dose enhancement by various sources and activation media

    International Nuclear Information System (INIS)

    Bakhshabadi, Mahdi; Ghorbani, Mahdi; Meigooni, Ali Soleimani

    2013-01-01

    In the present study, a number of brachytherapy sources and activation media were simulated using MCNPX code and the results were analyzed based on the dose enhancement factor values. Furthermore, two new brachytherapy sources ( 131 Cs and a hypothetical 170 Tm) were evaluated for their application in photon activation therapy (PAT). 125 I, 103 Pd, 131 Cs and hypothetical 170 Tm brachytherapy sources were simulated in water and their dose rate constant and the radial dose functions were compared with previously published data. The sources were then simulated in a soft tissue phantom which was composed of Ag, I, Pt or Au as activation media uniformly distributed in the tumour volume. These simulations were performed using the MCNPX code, and dose enhancement factor (DEF) was obtained for 7, 18 and 30 mg/ml concentrations of the activation media. Each source, activation medium and concentration was evaluated separately in a separate simulation. The calculated dose rate constant and radial dose functions were in agreement with the published data for the aforementioned sources. The maximum DEF was found to be 5.58 for a combination of the 170 Tm source with 30 mg/ml concentration of I. The DEFs for 131 Cs and 170 Tm sources for all the four activation media were higher than those for other sources and activation media. From this point of view, these two sources can be more useful in photon activation therapy with photon emitter sources. Furthermore, 131 Cs and 170 Tm brachytherapy sources can be proposed as new options for use in the field of PAT.

  14. Four Forensic Entomology Case Studies: Records and Behavioral Observations on Seldom Reported Cadaver Fauna With Notes on Relevant Previous Occurrences and Ecology.

    Science.gov (United States)

    Lindgren, Natalie K; Sisson, Melissa S; Archambeault, Alan D; Rahlwes, Brent C; Willett, James R; Bucheli, Sibyl R

    2015-03-01

    A yearlong survey of insect taxa associated with human decomposition was conducted at the Southeast Texas Applied Forensic Science (STAFS) facility located in the Center for Biological Field Studies of Sam Houston State University in Huntsville, TX. During this study, four insect-cadaver interactions were observed that represent previously poorly documented yet forensically significant interactions: Syrphidae maggots colonized a corpse in an aquatic situation; Psychodidae adults mated and oviposited on an algal film that was present on a corpse that had been recently removed from water; several Panorpidae were the first insects to feed upon a freshly placed corpse in the autumn; and a noctuid caterpillar was found chewing and ingesting dried human skin. Baseline knowledge of insect-cadaver interactions is the foundation of forensic entomology, and unique observations have the potential to expand our understanding of decomposition ecology. © The Author 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  15. Sealed source and device removal and consolidation feasibility study

    International Nuclear Information System (INIS)

    Ward, J.E.; Carter, J.G.; Meyers, R.L.

    1993-02-01

    The purpose of this study is to assess the feasibility of removing Greater-Than-Class C (GTCC) sealed sources from their containment device and consolidating them for transport to a storage or disposal facility. A sealed source is a sealed capsule containing a radioactive material that is placed in a device providing radioactive containment. It is used in the medical, industrial, research, and food-processing communities for calibrating, measuring, gauging, controlling processes, and testing. This feasibility study addresses the key operational, safety, regulatory, and financial requirements of the removal/consolidation process. This report discusses the process to receive, handle, repackage, and ship these sources to an interim or dedicated storage facility until a final disposal repository can be built and become operational (∼ c. 2010). The study identifies operational and facility requirements to perform this work. Hanford, other DOE facilities, and private hot-cell facilities were evaluated to determine which facilities could perform this work. The personnel needed, design and engineering, facility preparation, process waste disposal requirements, and regulatory compliance were evaluated to determine the cost to perform this work. Cost requirements for items that will have to meet future changing regulatory requirements for transportation, transportation container design and engineering, and disposal were not included in this study. The cost associated with in-process consolidation of the sealed sources reported in this study may have not been modified for inflation and were based on 1992 dollars. This study shows that sealed source consolidation is possible with minimal personnel exposure, and would reduce the risk of radioactive releases to the environment. An initial pilot-scale operation could evaluate the possible methods to reduce the cost and consolidate sources

  16. Langmuir probe studies on a RF ion source for NBI

    International Nuclear Information System (INIS)

    McNeely, P.; Heineman, B.; Kraus, W.; Riedl, R.; Speth, E.; Vollmer, O.

    2001-01-01

    IPP Garching has been developing a RF ion source for H - production. In order to improve the data quality a new scanning probe system with passive RF compensation has been installed on the Type VI ion source on the BATMAN test stand. Using this probe, measurements have been carried out to study changes to the plasma parameters (electron density, electron temperature, and plasma potential) due to variation in the source operating conditions. The data were collected at a source pressure of 0.5 Pa and with 60±5 kW applied RF power. Presented are some of the results of these measurements, focusing on the effect of: argon seeding, addition of Cs to the source, and the newly added Faraday screen. The electron density behaves in a fashion that agrees with the theory of ambipolar diffusion. Typically there is little change to the average electron energy observed regardless of which effect is considered. The plasma potential shows the most significant changes with external source conditions, both in value for all cases and shape when the Faraday screen was added

  17. Late tamoxifen in patients previously operated for breast cancer without postoperative tamoxifen: 5-year results of a single institution randomised study

    International Nuclear Information System (INIS)

    Veronesi, Andrea; Miolo, GianMaria; Magri, Maria D; Crivellari, Diana; Scalone, Simona; Bidoli, Ettore; Lombardi, Davide

    2010-01-01

    A population of breast cancer patients exists who, for various reasons, never received adjuvant post-operative tamoxifen (TAM). This study was aimed to evaluate the role of late TAM in these patients. From 1997 to 2003, patients aged 35 to 75 years, operated more than 2 years previously for monolateral breast cancer without adjuvant TAM, with no signs of metastases and no contraindication to TAM were randomized to TAM 20 mg/day orally for 2 years or follow-up alone. Events were categorized as locoregional relapse, distant metastases, metachronous breast cancer, tumours other than breast cancer and death from any causes, whichever occurred first. The sample size (197 patients per arm, plus 10% allowance) was based on the assumption of a 30% decrease in the number of events occurring at a rate of 5% annually in the 10 years following randomization. Four hundred and thirty-three patients were randomized in the study (TAM 217, follow-up 216). Patients characteristics (TAM/follow-up) included: median age 55/55 years, median time from surgery 25/25 months (range, 25-288/25-294), in situ carcinoma 18/24, oestrogen receptor (ER) positive in 75/68, negative in 70/57, unknown in 72/91 patients. Previous adjuvant treatment included chemotherapy in 131/120 and an LHRH analogue in 11/13 patients. Thirty-six patients prematurely discontinued TAM after a median of 1 month, mostly because of subjective intolerance. Eighty-three events (TAM 39, follow-up 44) occurred: locoregional relapse in 10/8, distant metastases in 14/16, metachronous breast cancer in 4/10, other tumours in 11/10 patients. Less ER-positive secondary breast cancers occurred in the TAM treated patients than in follow-up patients (1 vs 10, p = 0.005). Event-free survival was similar in both groups of patients. This 5-year analysis revealed significantly less metachronous ER-positive breast cancers in the TAM treated patients. No other statistically significant differences have emerged thus far

  18. Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Prevented Weight Regain in Obese Women with Polycystic Ovary Syndrome Previously Treated with Liraglutide: A Pilot Randomized Study.

    Science.gov (United States)

    Ferjan, Simona; Janez, Andrej; Jensterle, Mojca

    2017-12-01

    Weight loss is often nonsustainable after liraglutide cessation. The present study is the first insight into the potential prevention of weight regain in obese subjects who have been withdrawn from liraglutide. We evaluated whether dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin in adjunct to metformin prevents body weight regain more effectively than metformin alone in obese polycystic ovary syndrome (PCOS) previously treated with liraglutide. A 12-week prospective randomized open-label study was conducted with 24 obese women with PCOS who had been pretreated with liraglutide 3.0 mg due to antiobesity management (aged 34.3 ± 6.8 years, body mass index [BMI] 36.3 ± 5.2 kg/m 2 , mean ± standard deviation). They were randomized to combined treatment (COMBO) with sitagliptin 100 mg per day (QD) and metformin (MET) 1000 mg twice daily (BID) (n = 12) or MET 1000 mg BID (n = 12). Lifestyle intervention was promoted in both groups. The primary outcome was change in anthropometric measures of obesity. Women treated with MET regain 4.7 ± 2.7 kg (P = 0.002) compared with a 0.9 ± 2.5 kg in COMBO (P = 0.147). BMI increased for 1.7 ± 0.9 kg/m 2 in MET (P = 0.002) compared with 0.3 ± 0.8 kg/m 2 increase in COMBO (P = 0.136). MET group regain 4.5% ± 2.5% of body weight as opposed to 0.8% ± 2.6% in COMBO. The between-treatment differences were significant for weight change (P weight change (P weight regain in obese women with PCOS previously treated with liraglutide.

  19. Review of SFR In-Vessel Radiological Source Term Studies

    International Nuclear Information System (INIS)

    Suk, Soo Dong; Lee, Yong Bum

    2008-10-01

    An effort has been made in this study to search for and review the literatures in public domain on the studies of the phenomena related to the release of radionuclides and aerosols to the reactor containment of the sodium fast reactor (SFR) plants (i.e., in-vessel source term), made in Japan and Europe including France, Germany and UK over the last few decades. Review work is focused on the experimental programs to investigate the phenomena related to determining the source terms, with a brief review on supporting analytical models and computer programs. In this report, the research programs conducted to investigate the CDA (core disruptive accident) bubble behavior in the sodium pool for determining 'primary' or 'instantaneous' source term are first introduced. The studies performed to determine 'delayed source term' are then described, including the various stages of phenomena and processes: fission product (FP) release from fuel , evaporation release from the surface of the pool, iodine mass transfer from fission gas bubble, FP deposition , and aerosol release from core-concrete interaction. The research programs to investigate the release and transport of FPs and aerosols in the reactor containment (i.e., in-containment source term) are not described in this report

  20. Study of two different radioactive sources for prostate brachytherapy treatment

    International Nuclear Information System (INIS)

    Pereira Neves, Lucio; Perini, Ana Paula; Souza Santos, William de; Caldas, Linda V.E.; Belinato, Walmir

    2015-01-01

    In this study we evaluated two radioactive sources for brachytherapy treatments. Our main goal was to quantify the absorbed doses on organs and tissues of an adult male patient, submitted to a brachytherapy treatment with two radioactive sources. We evaluated a 192 Ir and a 125 I radioactive sources. The 192 Ir radioactive source is a cylinder with 0.09 cm in diameter and 0.415 cm long. The 125 I radioactive source is also a cylinder, with 0.08 cm in diameter and 0.45 cm long. To evaluate the absorbed dose distribution on the prostate, and other organs and tissues of an adult man, a male virtual anthropomorphic phantom MASH, coupled in the radiation transport code MCNPX 2.7.0, was employed.We simulated 75, 90 and 102 radioactive sources of 125 I and one of 192 Ir, inside the prostate, as normally used in these treatments, and each treatment was simulated separately. As this phantom was developed in a supine position, the displacement of the internal organs of the chest, compression of the lungs and reduction of the sagittal diameter were all taken into account. For the 192 Ir, the higher doses values were obtained for the prostate and surrounding organs, as the colon, gonads and bladder. Considering the 125 I sources, with photons with lower energies, the doses to organs that are far from the prostate were lower. All values for the dose rates are in agreement with those recommended for brachytherapy treatments. Besides that, the new seeds evaluated in this work present usefulness as a new tool in prostate brachytherapy treatments, and the methodology employed in this work may be applied for other radiation sources, or treatments. (authors)

  1. Study of two different radioactive sources for prostate brachytherapy treatment

    Energy Technology Data Exchange (ETDEWEB)

    Pereira Neves, Lucio; Perini, Ana Paula [Instituto de Fisica, Universidade Federal de Uberlandia, Caixa Postal 593, 38400-902, Uberlandia, MG (Brazil); Souza Santos, William de; Caldas, Linda V.E. [Instituto de Pesquisas Energeticas e Nucleares, Comissao Nacional de Energia Nuclear, IPENCNEN/SP, Av. Prof. Lineu Prestes, 2242, Cidade Universitaria, 05508-000 Sao Paulo, SP (Brazil); Belinato, Walmir [Departamento de Ensino, Instituto Federal de Educacao, Ciencia e Tecnologia da Bahia, Campus Vitoria da Conquista, Zabele, Av. Amazonas 3150, 45030-220 Vitoria da Conquista, BA (Brazil)

    2015-07-01

    In this study we evaluated two radioactive sources for brachytherapy treatments. Our main goal was to quantify the absorbed doses on organs and tissues of an adult male patient, submitted to a brachytherapy treatment with two radioactive sources. We evaluated a {sup 192}Ir and a {sup 125}I radioactive sources. The {sup 192}Ir radioactive source is a cylinder with 0.09 cm in diameter and 0.415 cm long. The {sup 125}I radioactive source is also a cylinder, with 0.08 cm in diameter and 0.45 cm long. To evaluate the absorbed dose distribution on the prostate, and other organs and tissues of an adult man, a male virtual anthropomorphic phantom MASH, coupled in the radiation transport code MCNPX 2.7.0, was employed.We simulated 75, 90 and 102 radioactive sources of {sup 125}I and one of {sup 192}Ir, inside the prostate, as normally used in these treatments, and each treatment was simulated separately. As this phantom was developed in a supine position, the displacement of the internal organs of the chest, compression of the lungs and reduction of the sagittal diameter were all taken into account. For the {sup 192}Ir, the higher doses values were obtained for the prostate and surrounding organs, as the colon, gonads and bladder. Considering the {sup 125}I sources, with photons with lower energies, the doses to organs that are far from the prostate were lower. All values for the dose rates are in agreement with those recommended for brachytherapy treatments. Besides that, the new seeds evaluated in this work present usefulness as a new tool in prostate brachytherapy treatments, and the methodology employed in this work may be applied for other radiation sources, or treatments. (authors)

  2. Study of an hybrid positron source using channeling for CLIC

    CERN Document Server

    Dadoun, O; Chehab, R; Poirier, F; Rinolfi, L; Strakhovenko, V; Variola, A; Vivoli, A

    2009-01-01

    The CLIC study considers the hybrid source using channeling as the baseline for positron production. The hybrid source uses a few GeV electron beam impinging on a crystal tungsten radiator. With the tungsten crystal oriented on its axis it results an intense, relatively low energy photon beam due mainly to channeling radiation. Those photons are then impinging on an amorphous tungsten target producing positrons by e+e− pair creation. In this note the optimization of the positron yield and the peak energy deposition density in the amorphous target are studied according to the distance between the crystal and the amorphous targets, the primary electron energy and the amorphous target thickness.

  3. In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case–control study

    International Nuclear Information System (INIS)

    Rivero, Javier; Luzardo, Octavio P.; Henríquez-Hernández, Luis A.; Machín, Rubén P.; Pestano, José; Zumbado, Manuel; Boada, Luis D.; Camacho, María; Valerón, Pilar F.

    2015-01-01

    Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action. - Highlights: • E-screen and A-screen of two mixtures of organochlorine pesticides (OCP) • Assay concentrations based on a previous breast cancer case–control study • Only non-cytotoxic concentrations assayed • Both OCP mixtures induce proliferation mediated by oestrogen receptor. • OCP mixture of breast cancer patients exhibits additional androgenic activity.

  4. In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case–control study

    Energy Technology Data Exchange (ETDEWEB)

    Rivero, Javier; Luzardo, Octavio P., E-mail: octavio.perez@ulpgc.es; Henríquez-Hernández, Luis A.; Machín, Rubén P.; Pestano, José; Zumbado, Manuel; Boada, Luis D.; Camacho, María; Valerón, Pilar F.

    2015-12-15

    Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action. - Highlights: • E-screen and A-screen of two mixtures of organochlorine pesticides (OCP) • Assay concentrations based on a previous breast cancer case–control study • Only non-cytotoxic concentrations assayed • Both OCP mixtures induce proliferation mediated by oestrogen receptor. • OCP mixture of breast cancer patients exhibits additional androgenic activity.

  5. A californium-252 source for radiobiological studies at Hiroshima University

    International Nuclear Information System (INIS)

    Kato, Kazuo; Takeoka, Seiji; Kuroda, Tokue; Tsujimura, Tomotaka; Kawami, Masaharu; Hoshi, Masaharu; Sawada, Shozo

    1987-01-01

    A 1.93 Ci (3.6 mg) californium-252 source was installed in the radiation facility of the Research Institute for Nuclear Medicine and Biology, Hiroshima University. This source produces fission neutrons (8.7 x 10 9 n/s at the time of its installation), which are similar to neutron spectrum of the atomic bombs. It is useful for studying biological effects of fission neutrons and neutron dosimetry. An apparatus was dosigned to accomodate this source and to apply it to such studies. It has resulted in profitable fission neutron exposures, while suppressing scattered neutrons and secondary gamma rays. This apparatus incorporates many safety systems, including one which interlocks with all of doors and an elevator serving the exposure room, so as to prevent accidents involving users. (author)

  6. Evaluation of the Widal tube agglutination test for the diagnosis of typhoid fever among children admitted to a rural hdospital in Tanzania and a comparison with previous studies

    Directory of Open Access Journals (Sweden)

    Malahiyo Rajabu

    2010-06-01

    Full Text Available Abstract Background The diagnosis of typhoid fever is confirmed by culture of Salmonella enterica serotype Typhi (S. typhi. However, a more rapid, simpler, and cheaper diagnostic method would be very useful especially in developing countries. The Widal test is widely used in Africa but little information exists about its reliability. Methods We assessed the performance of the Widal tube agglutination test among febrile hospitalized Tanzanian children. We calculated the sensitivity, specificity, positive predictive value (PPV, and negative predictive value (NPV of various anti-TH and -TO titers using culture-confirmed typhoid fever cases as the "true positives" and all other febrile children with blood culture negative for S. typhi as the "true negatives." Results We found that 16 (1% of 1,680 children had culture-proven typhoid fever. A single anti-TH titer of 1:80 and higher was the optimal indicator of typhoid fever. This had a sensitivity of 75%, specificity of 98%, NPV of 100%, but PPV was only 26%. We compared our main findings with those from previous studies. Conclusion Among febrile hospitalized Tanzanian children with a low prevalence of typhoid fever, a Widal titer of ≥ 1:80 performed well in terms of sensitivity, specificity, and NPV. However a test with improved PPV that is similarly easy to apply and cost-efficient is desirable.

  7. Caring for women wanting a vaginal birth after previous caesarean section: A qualitative study of the experiences of midwives and obstetricians.

    Science.gov (United States)

    Foureur, Maralyn; Turkmani, Sabera; Clack, Danielle C; Davis, Deborah L; Mollart, Lyndall; Leiser, Bernadette; Homer, Caroline S E

    2017-02-01

    One of the greatest contributors to the overall caesarean section rate is elective repeat caesarean section. Decisions around mode of birth are often complex for women and influenced by the views of the doctors and midwives who care for and counsel women. Women may be more likely to choose a repeat elective caesarean section (CS) if their health care providers lack skills and confidence in supporting vaginal birth after caesarean section (VBAC). To explore the views and experiences of providers in caring for women considering VBAC, in particular the decision-making processes and the communication of risk and safety to women. A descriptive interpretive method was utilised. Four focus groups with doctors and midwives were conducted. The central themes were: 'developing trust', 'navigating the system' and 'optimising support'. The impact of past professional experiences; the critical importance of continuity of carer and positive relationships; the ability to weigh up risks versus benefits; and the language used were all important elements. The role of policy and guidelines on providing standardised care for women who had a previous CS was also highlighted. Midwives and doctors in this study were positively oriented towards assisting and supporting women to attempt a VBAC. Care providers considered that women who have experienced a prior CS need access to midwifery continuity of care with a focus on support, information-sharing and effective communication. Copyright © 2016 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  8. Gefitinib plus cisplatin and radiotherapy in previously untreated head and neck squamous cell carcinoma: A phase II, randomized, double-blind, placebo-controlled study

    International Nuclear Information System (INIS)

    Gregoire, Vincent; Hamoir, Marc; Chen Changhu; Kane, Madeleine; Kawecki, Andrzej; Julka, Pramod K.; Wang, Hung-Ming; Prasad, Srihari; D'Cruz, Anil K.; Radosevic-Jelic, Ljiljana; Kumar, Rejnish R.; Korzeniowski, Stanislaw; Fijuth, Jacek; Machiels, Jean-Pascal; Sellers, Mark V.; Tchakov, Ilian; Raben, David

    2011-01-01

    Background and purpose: To assess the efficacy and safety of gefitinib given concomitantly and/or as maintenance therapy to standard cisplatin/radiotherapy for previously untreated, unresected, stage III/IV non-metastatic SCCHN. Materials and methods: In this phase II, double-blind, study, 226 patients were randomized to gefitinib 250 mg/day, 500 mg/day or placebo in two phases: a concomitant phase (gefitinib or placebo with chemoradiotherapy), followed by a maintenance phase (gefitinib or placebo alone). Primary endpoint was local disease control rate (LDCR) at 2 years; secondary endpoints were LDCR at 1 year, objective response rate, progression-free survival, overall survival, and safety and tolerability. Results: Gefitinib (250 and 500 mg/day) did not improve 2-year LDCR compared with placebo either when given concomitantly with chemoradiotherapy (32.7% vs. 33.6%, respectively; OR 0.921, 95% CI 0.508, 1.670 [1-sided p = 0.607]) or as maintenance therapy (28.8% vs. 37.4%, respectively; OR 0.684, 95% CI 0.377, 1.241 [1-sided p = 0.894]). Secondary efficacy outcomes were broadly consistent with the 2-year LDCR results. In both doses, gefitinib was well-tolerated and did not adversely affect the safety and tolerability of concomitant chemoradiotherapy. Conclusion: Gefitinib was well-tolerated, but did not improve efficacy compared with placebo when given concomitantly with chemoradiotherapy, or as maintenance therapy alone.

  9. Study of non-metallic inclusion sources in steel

    International Nuclear Information System (INIS)

    Khons, Ya.; Mrazek, L.

    1976-01-01

    A study of potential inclusion sources was carried out at the Tvinec steel plant using an unified labelling procedure for different sources. A lanthanum oxide labelling method has been used for refractories with the subsequent La determination in steel by the neutron activation analysis. Samarium and cerium oxides and the 141 Ce radionuclide have been used in conjunction with the testing. The following sources of exogenous inclusions have been studied: 1)Refractory material comprising fireclay and corundum for steel-teeming trough in open-heart furnaces; 2) Fireclay bottom-pouring refractories; 3) Steel-teeming laddle lining; 4) Heat-insulating and exothermic compounds for steel ingots; 5) Vacuum treatment plant lining; 6) Open-hearth and electric arc furnace slag. The major oxide inclusion source in steel was found to be represented by the furnace slag, since it forms about 40 p.c. of all oxide inclusions. The contributions of the remaining sources did not exceede 5 p.c. each

  10. Study of liquid hydrogen and liquid deuterium cold neutron sources

    International Nuclear Information System (INIS)

    Harig, H.D.

    1969-01-01

    In view of the plant of the cold neutron source for a high flux reactor (maximal thermal flux of about 10 15 n/cm 2 s) an experimental study of several cold sources of liquid hydrogen and liquid deuterium has been made in a low power reactor (100 kW, about 10 12 n/cm 2 s). We have investigated: -cold neutron sources of liquid hydrogen shaped as annular layers of different thickness. Normal liquid hydrogen was used as well as hydrogen with a high para-percentage. -Cold neutron sources of liquid deuterium in cylinders of 18 and 38 cm diameter. In this case the sources could be placed into different positions to the reactor core within the heavy water reflector. This report gives a general description of the experimental device and deals more detailed with the design of the cryogenic systems. Then, the measured results are communicated, interpreted and finally compared with those of a theoretical study about the same cold moderators which have been the matter of the experimental investigation. (authors) [fr

  11. LIGHT SOURCE: A simulation study of Tsinghua Thomson scattering X-ray source

    Science.gov (United States)

    Tang, Chuan-Xiang; Li, Ren-Kai; Huang, Wen-Hui; Chen, Huai-Bi; Du, Ying-Chao; Du, Qiang; Du, Tai-Bin; He, Xiao-Zhong; Hua, Jian-Fei; Lin, Yu-Zhen; Qian, Hou-Jun; Shi, Jia-Ru; Xiang, Dao; Yan, Li-Xin; Yu, Pei-Cheng

    2009-06-01

    Thomson scattering X-ray sources are compact and affordable facilities that produce short duration, high brightness X-ray pulses enabling new experimental capacities in ultra-fast science studies, and also medical and industrial applications. Such a facility has been built at the Accelerator Laboratory of Tsinghua University, and upgrade is in progress. In this paper, we present a proposed layout of the upgrade with design parameters by simulation, aiming at high X-ray pulses flux and brightness, and also enabling advanced dynamics studies and applications of the electron beam. Design and construction status of main subsystems are also presented.

  12. Recommendation of ruthenium source for sludge batch flowsheet studies

    Energy Technology Data Exchange (ETDEWEB)

    Woodham, W. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-09-13

    Included herein is a preliminary analysis of previously-generated data from sludge batches 7a, 7b, 8, and 9 sludge simulant and real-waste testing, performed to recommend a form of ruthenium for future sludge batch simulant testing under the nitric-formic flowsheet. Focus is given to reactions present in the Sludge Receipt and Adjustment Tank cycle, given that this cycle historically produces the most changes in chemical composition during Chemical Process Cell processing. Data is presented and analyzed for several runs performed under the nitric-formic flowsheet, with consideration given to effects on the production of hydrogen gas, nitrous oxide gas, consumption of formate, conversion of nitrite to nitrate, and the removal and recovery of mercury during processing. Additionally, a brief discussion is given to the effect of ruthenium source selection under the nitric-glycolic flowsheet. An analysis of data generated from scaled demonstration testing, sludge batch 9 qualification testing, and antifoam degradation testing under the nitric-glycolic flowsheet is presented. Experimental parameters of interest under the nitric-glycolic flowsheet include N2O production, glycolate destruction, conversion of glycolate to formate and oxalate, and the conversion of nitrite to nitrate. To date, the number of real-waste experiments that have been performed under the nitric-glycolic flowsheet is insufficient to provide a complete understanding of the effects of ruthenium source selection in simulant experiments with regard to fidelity to real-waste testing. Therefore, a determination of comparability between the two ruthenium sources as employed under the nitric-glycolic flowsheet is made based on available data in order to inform ruthenium source selection for future testing under the nitric-glycolic flowsheet.

  13. Prevalence of pain in the head, back and feet in refugees previously exposed to torture: a ten-year follow-up study

    DEFF Research Database (Denmark)

    Olsen, Dorthe Reff; Montgomery, Edith; Bøjholm, Søren

    2007-01-01

    AIM: To estimate change over 10 years concerning the prevalence of pain in the head, back and feet, among previously tortured refugees settled in Denmark, and to compare associations between methods of torture and prevalent pain at baseline and at 10-year follow-up. METHODS: 139 refugees previous...... associated with the type and bodily focus of the torture. This presents a considerable challenge to future evidence-based development of effective treatment programs....

  14. Immunogenicity and safety of tetravalent dengue vaccine in 2-11 year-olds previously vaccinated against yellow fever: randomized, controlled, phase II study in Piura, Peru.

    Science.gov (United States)

    Lanata, Claudio F; Andrade, Teresa; Gil, Ana I; Terrones, Cynthia; Valladolid, Omar; Zambrano, Betzana; Saville, Melanie; Crevat, Denis

    2012-09-07

    In a randomized, placebo-controlled, monocenter, observer blinded study conducted in an area where dengue is endemic, we assessed the safety and immunogenicity of a recombinant, live, attenuated, tetravalent dengue vaccine candidate (CYD-TDV) in 2-11 year-olds with varying levels of pre-existing yellow-fever immunity due to vaccination 1-7 years previously. 199 children received 3 injections of CYD-TDV (months 0, 6 and 12) and 99 received placebo (months 0 and 6) or pneumococcal polysaccharide vaccine (month 12). One month after the third dengue vaccination, serotype specific neutralizing antibody GMTs were in the range of 178-190 (1/dil) (versus 16.7-38.1 in the control group), a 10-20 fold-increase from baseline, and 94% of vaccines were seropositive to all four serotypes (versus 39% in the control group). There were no vaccine-related SAEs. The observed reactogenicity profile was consistent with phase I studies, with severity grade 1-2 injection site pain, headache, malaise and fever most frequently reported and no increase after subsequent vaccinations. Virologically confirmed dengue cases were seen after completion of the 3 doses: 1 in the CYD-TDV group (N=199), and 3 in the control group (N=99). A 3-dose regimen of CYD-TDV had a good safety profile in 2-11 year olds with a history of YF vaccination and elicited robust antibody responses that were balanced against the four serotypes. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. A phase II study of VP-16-ifosfamide-cisplatin combination chemotherapy plus early concurrent thoracic irradiation for previously untreated limited small cell lung cancer

    International Nuclear Information System (INIS)

    Woo, In Sook; Park, Young Suk; Kwon, Sung Hee

    2000-01-01

    At present the addition of thoracic irradiation to combination chemotherapy is a standard treatment for limited staged small cell ling cancer. However, there is still controversy about the optimum timing of chest irradiation. We conducted a phase II study of etoposide (VP-16)-ifosfamide-cisplatin (VIP) combination chemotherapy plus early concurrent thoracic irradiation for the patients with previously untreated limited small cell lung cancer in order to assess if the treatment modality could improve the response rate and the toxicity. Forty-four patients with limited small cell lung cancer were treated with etoposide-ifosfamide-cisplatin and concurrent thoracic irradiation. Combination chemotherapy consisted of etoposide 100 mg/m 2 (on day 1-3), ifosfamide 1000 mg/m 2 (on days 1 and 2) and cisplatin 100 mg/m 2 (on day 1). Concurrent thoracic irradiation consisted of a total of 4000 cGy over 4 weeks starting on the first day of the first chemotherapy. All patients who showed a complete response were given prophylactic cranial irradiation for 2.5 weeks. Forty-four of the 49 patients who entered the study from May 1994 to August 1998 were evaluable. The median age was 59 years and 40 patients had a performance status of 0 or 1. The median survival time was 22.5 months. Twenty-eight patients (62%) showed a complete response and 16 (38%) a partial response. Twenty-four patients (54%) developed grade 3 or 4 neutropenia; there was a 9% RTOG score 3 or 4 esophagitis. VIP combination chemotherapy and early concurrent thoracic irradiation for patients with limited stage small cell lung cancer revealed excellent antitumor response with tolerable toxicity. (author)

  16. A Comparative Study Of Source Location And Depth Estimates From ...

    African Journals Online (AJOL)

    ... the analytic signal amplitude (ASA) and the local wave number (LWN) of the total intensity magnetic field. In this study, a synthetic magnetic field due to four buried dipoles was analysed to show that estimates of source location and depth can be improved significantly by reducing the data to the pole prior to the application ...

  17. A study investigating sound sources and noise levels in neonatal ...

    African Journals Online (AJOL)

    Background. Exposure to noise in the neonatal intensive care unit (NICU) has the potential to affect neonatal auditory development, sleep patterns and physiological stability, thus impacting on developmental progress. Objectives. This study aimed to identify noise sources in three NICUs in Johannesburg, South Africa, and ...

  18. Study of localized photon source in space of measures

    International Nuclear Information System (INIS)

    Lisi, M.

    2010-01-01

    In this paper we study a three-dimensional photon transport problem in an interstellar cloud, with a localized photon source inside. The problem is solved indirectly, by defining the adjoint of an operator acting on an appropriate space of continuous functions. By means of sun-adjoint semi groups theory of operators in a Banach space of regular Borel measures, we prove existence and uniqueness of the solution of the problem. A possible approach to identify the localization of the photon source is finally proposed.

  19. Open-Source RTOS Space Qualification: An RTEMS Case Study

    Science.gov (United States)

    Zemerick, Scott

    2017-01-01

    NASA space-qualification of reusable off-the-shelf real-time operating systems (RTOSs) remains elusive due to several factors notably (1) The diverse nature of RTOSs utilized across NASA, (2) No single NASA space-qualification criteria, lack of verification and validation (V&V) analysis, or test beds, and (3) different RTOS heritages, specifically open-source RTOSs and closed vendor-provided RTOSs. As a leader in simulation test beds, the NASA IV&V Program is poised to help jump-start and lead the space-qualification effort of the open source Real-Time Executive for Multiprocessor Systems (RTEMS) RTOS. RTEMS, as a case-study, can be utilized as an example of how to qualify all RTOSs, particularly the reusable non-commercial (open-source) ones that are gaining usage and popularity across NASA. Qualification will improve the overall safety and mission assurance of RTOSs for NASA-agency wide usage. NASA's involvement in space-qualification of an open-source RTOS such as RTEMS will drive the RTOS industry toward a more qualified and mature open-source RTOS product.

  20. A Study on Water Pollution Source Localization in Sensor Networks

    Directory of Open Access Journals (Sweden)

    Jun Yang

    2016-01-01

    Full Text Available The water pollution source localization is of great significance to water environment protection. In this paper, a study on water pollution source localization is presented. Firstly, the source detection is discussed. Then, the coarse localization methods and the localization methods based on diffusion models are introduced and analyzed, respectively. In addition, the localization method based on the contour is proposed. The detection and localization methods are compared in experiments finally. The results show that the detection method using hypotheses testing is more stable. The performance of the coarse localization algorithm depends on the nodes density. The localization based on the diffusion model can yield precise localization results; however, the results are not stable. The localization method based on the contour is better than the other two localization methods when the concentration contours are axisymmetric. Thus, in the water pollution source localization, the detection using hypotheses testing is more preferable in the source detection step. If concentration contours are axisymmetric, the localization method based on the contour is the first option. And, in case the nodes are dense and there is no explicit diffusion model, the coarse localization algorithm can be used, or else the localization based on diffusion models is a good choice.

  1. Systematic study of source mask optimization and verification flows

    Science.gov (United States)

    Ben, Yu; Latypov, Azat; Chua, Gek Soon; Zou, Yi

    2012-06-01

    Source mask optimization (SMO) emerged as powerful resolution enhancement technique (RET) for advanced technology nodes. However, there is a plethora of flow and verification metrics in the field, confounding the end user of the technique. Systemic study of different flows and the possible unification thereof is missing. This contribution is intended to reveal the pros and cons of different SMO approaches and verification metrics, understand the commonality and difference, and provide a generic guideline for RET selection via SMO. The paper discusses 3 different type of variations commonly arise in SMO, namely pattern preparation & selection, availability of relevant OPC recipe for freeform source and finally the metrics used in source verification. Several pattern selection algorithms are compared and advantages of systematic pattern selection algorithms are discussed. In the absence of a full resist model for SMO, alternative SMO flow without full resist model is reviewed. Preferred verification flow with quality metrics of DOF and MEEF is examined.

  2. A Study on Improvement of Algorithm for Source Term Evaluation

    International Nuclear Information System (INIS)

    Park, Jeong Ho; Park, Do Hyung; Lee, Jae Hee

    2010-03-01

    The program developed by KAERI for source term assessment of radwastes from the advanced nuclear fuel cycle consists of spent fuel database analysis module, spent fuel arising projection module, and automatic characterization module for radwastes from pyroprocess. To improve the algorithm adopted the developed program, following items were carried out: - development of an algorithm to decrease analysis time for spent fuel database - development of setup routine for a analysis procedure - improvement of interface for spent fuel arising projection module - optimization of data management algorithm needed for massive calculation to estimate source terms of radwastes from advanced fuel cycle The program developed through this study has a capability to perform source term estimation although several spent fuel assemblies with different fuel design, initial enrichment, irradiation history, discharge burnup, and cooling time are processed at the same time in the pyroprocess. It is expected that this program will be very useful for the design of unit process of pyroprocess and disposal system

  3. Study of the Release Process of Open Source Software: Case Study

    OpenAIRE

    Eide, Tor Erik

    2007-01-01

    This report presents the results of a case study focusing on the release process of open source projects initiated with commercial motives. The purpose of the study is to gain an increased understanding of the release process, how a community can be attracted to the project, and how the interaction with the community evolves in commercial open source initiatives. Data has been gathered from four distinct sources to form the basis of this thesis. A thorough review of the open source literatu...

  4. Food and Drug Administration criteria for the diagnosis of drug-induced valvular heart disease in patients previously exposed to benfluorex: a prospective multicentre study.

    Science.gov (United States)

    Maréchaux, Sylvestre; Rusinaru, Dan; Jobic, Yannick; Ederhy, Stéphane; Donal, Erwan; Réant, Patricia; Arnalsteen, Elise; Boulanger, Jacques; Garban, Thierry; Ennezat, Pierre-Vladimir; Jeu, Antoine; Szymanski, Catherine; Tribouilloy, Christophe

    2015-02-01

    The Food and Drug Administration (FDA) criteria for diagnosis of drug-induced valvular heart disease (DIVHD) are only based on the observation of aortic regurgitation ≥ mild and/or mitral regurgitation ≥ moderate. We sought to evaluate the diagnostic value of FDA criteria in a cohort of control patients and in a cohort of patients exposed to a drug (benfluorex) known to induce VHD. This prospective, multicentre study included 376 diabetic control patients not exposed to valvulopathic drugs and 1000 subjects previously exposed to benfluorex. Diagnosis of mitral or aortic DIVHD was based on a combined functional and morphological echocardiographic analysis of cardiac valves. Patients were classified according to the FDA criteria [mitral or aortic-FDA(+) and mitral or aortic-FDA(-)]. Among the 376 control patients, 2 were wrongly classified as mitral-FDA(+) and 17 as aortic-FDA(+) (0.53 and 4.5% of false positives, respectively). Of those exposed to benfluorex, 48 of 58 with a diagnosis of mitral DIVHD (83%) were classified as mitral-FDA(-), and 901 of the 910 patients (99%) without a diagnosis of the mitral DIVHD group were classified as mitral-FDA(-). All 40 patients with a diagnosis of aortic DIVHD were classified as aortic-FDA(+), and 105 of the 910 patients without a diagnosis of aortic DIVHD (12%) were classified aortic-FDA(+). Older age and lower BMI were independent predictors of disagreement between FDA criteria and the diagnosis of DIVHD in patients exposed to benfluorex (both P ≤ 0.001). FDA criteria solely based on the Doppler detection of cardiac valve regurgitation underestimate for the mitral valve and overestimate for the aortic valve the frequency of DIVHD. Therefore, the diagnosis of DIVHD must be based on a combined echocardiographic and Doppler morphological and functional analysis of cardiac valves. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

  5. SAFETY AND ACTIVITY OF TEMSIROLIMUS AND BEVACIZUMAB IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA PREVIOUSLY TREATED WITH TYROSINE KINASE INHIBITORS: A PHASE 2 CONSORTIUM STUDY

    Science.gov (United States)

    Merchan, Jaime R.; Qin, Rui; Pitot, Henry; Picus, Joel; Liu, Glenn; Fitch, Tom; Maples, William J.; Flynn, Patrick J.; Fruth, Briant F.; Erlichman, Charles

    2015-01-01

    Purpose Bevacizumab or Temsirolimus regimens have clinical activity in the first line treatment of advanced renal cell carcinoma (RCC). This phase I/II trial was conducted to determine the safety of combining both agents and its efficacy in RCC patients who progressed on at least one prior anti-VEGF receptor tyrosine kinase inhibitor (RTKI) agent. Methods In the phase I portion, eligible patients were treated with Temsirolimus (25 mg IV weekly) and escalating doses of IV Bevacizumab (level 1=5mg/kg; level 2=10 mg/kg) every other week. The primary endpoint for the phase II portion (RTKI resistant patients) was the 6-month progression free rate. Secondary endpoints were response rate, toxicity evaluation, PFS and OS. Results MTD was not reached at the maximum dose administered in 12 phase I patients. Forty evaluable patients were treated with the phase II recommended dose (Temsirolimus 25 mg IV weekly and Bevacizumab 10 mg/kg IV every two weeks). The 6-month progression free rate was 40% (16/40 pts). Median PFS was 5.9 (4-7.8) months, and median OS was 20.6 (11.5-23.7) months. Partial response/stable/progressive disease were seen in 23%/63%/14% of patients. Most common grade 3-4 AEs included fatigue (17.8%), hypertriglyceridemia (11.1%), stomatitis (8.9%), proteinuria (8.9%), abdominal pain (6.7%), and anemia (6.7%). Baseline levels of serum sFLT-1 and VEGF-A were inversely correlated with PFS and OS, respectively. Conclusions Temsirolimus and Bevacizumab is a feasible combination in patients with advanced RCC previously exposed to oral anti-VEGF agents. The safety and efficacy results warrant further confirmatory studies in this patient population. PMID:25556030

  6. Low-calorie energy drink improves physiological response to exercise in previously sedentary men: a placebo-controlled efficacy and safety study.

    Science.gov (United States)

    Lockwood, Christopher M; Moon, Jordan R; Smith, Abbie E; Tobkin, Sarah E; Kendall, Kristina L; Graef, Jennifer L; Cramer, Joel T; Stout, Jeffrey R

    2010-08-01

    Energy drink use has grown despite limited research to support efficacy or safety and amid concerns when combined with exercise. The purpose of this study was to assess the effects of 10 weeks of once-daily energy drink consumption or energy drink consumption with exercise on measures of body composition, cardiorespiratory fitness, strength, mood, and safety in previously sedentary males. Thirty-eight males were randomly assigned to energy drink + exercise (EX-A), energy drink (NEX-A), placebo + exercise (EX-B), or placebo (NEX-B). All participants consumed 1 drink per day for 10 weeks; EX-A and EX-B participated in 10 weeks of resistance and endurance exercise. Testing was performed before (PRE) and after (POST) the 10-week intervention. No significant (p > 0.05) changes were observed for body composition, fitness, or strength in NEX-A; however, significantly greater decreases in fat mass and percentage body fat and increases in VO2peak were observed in EX-A versus EX-B. Ventilatory threshold (VT), minute ventilation, VO2 at VT, and power output at VT improved significantly PRE to POST in EX-A but not in EX-B or nonexercising groups. Clinical markers for hepatic, renal, cardiovascular, and immune function, as determined by PRE and POST blood work revealed no adverse effects in response to the energy drink. Mood was not affected by energy drink use. Absent energy restriction or other dietary controls, chronic ingestion of a once-daily low-calorie energy drink appears ineffective at improving body composition, cardiorespiratory fitness, or strength in sedentary males. However, when combined with exercise, preworkout energy drink consumption may significantly improve some physiological adaptations to combined aerobic and resistance training.

  7. Phase I/II study of gefitinib (Iressa(®)) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer.

    Science.gov (United States)

    Han, Ji-Youn; Lee, Soo Hyun; Lee, Geon Kook; Yun, Tak; Lee, Young Joo; Hwang, Kum Hui; Kim, Jin Young; Kim, Heung Tae

    2015-03-01

    Vorinostat has been shown to overcome resistance to gefitinib. We performed a phase I/II study combining gefitinib with vorinostat in previously treated non-small cell lung cancer (NSCLC). A 3 + 3 dose-escalation design was used to determine maximum tolerated dose (MTD) and recommended phase II dose (RP2D). Three dose levels were tested: 250 mg/day gefitinib on days 1-28 and 200, 300 or 400 mg/day vorinostat on days 1-7, and 15-21 out of every 28 days. The primary endpoint was median progression-free survival (PFS). Fifty-two patients were enrolled and treated (43 in phase II). The median age was 59 years, 28 patients were male, 44 had adenocarcinoma, 29 had never smoked, and 36 had undergone one prior treatment. Twenty-two patients exhibited sensitive EGFR mutations. Planned dose escalation was completed without reaching the MTD. The RP2D was 250 mg gefitinib and 400 mg vorinostat. In 43 assessable patients in phase II, the median PFS was 3.2 months; the overall survival (OS) was 19.0 months. There were 16 partial responses and six cases of stable disease. In EGFR-mutant NSCLC, response rate was 77 %, median PFS was 9.1 months, and median OS was 24.1 months. The most common adverse events were anorexia and diarrhea. Treatment with 250 mg gefitinib daily with biweekly 400 mg/day vorinostat was feasible and well tolerated. In an unselected patient population, this combination dose did not improve PFS. However, this combination showed a potential for improving efficacy of gefitinib in EGFR-mutant NSCLC (NCT01027676).

  8. Effect of donepezil in patients with Alzheimer's disease previously untreated or treated with memantine or nootropic agents in Germany: an observational study.

    Science.gov (United States)

    Klinger, Tatjana; Ibach, Bernd; Schoenknecht, Peter; Kamleiter, Martin; Silver, Gabrielle; Schroeder, Johannes; Mielke, Ruediger

    2005-05-01

    This open-label, prospective, observational, Post-Marketing Surveillance (PMS) study assessed the efficacy and safety of donepezil in patients who had been switched from therapies currently used in Germany to treat Alzheimer's disease (AD), such as memantine and nootropics, due to insufficient efficacy or poor tolerability. A treatment-naive population was included as a comparator. Patients with AD were treated with donepezil and observed for a period of approximately 3 months. A cognitive assessment was made using the Mini-Mental State Examination (MMSE). Quality of life (QoL) was assessed by the investigators who answered the question 'How did therapy with donepezil influence the QoL of the patient and/or his family over the observation period?' and was graded using three ratings: improved/unchanged/worsened. Adverse events (AEs) were also monitored. A total of 913 patients entered the study (mean +/- SD MMSE score 18.03 +/- 5.34). Efficacy assessments were analyzed for three groups: an overall group of patients who had received any form of prior AD drug therapy (N+ group; n = 709); a subgroup of patients from the N+ group who had received prior memantine therapy only (M+ group; n = 111) and patients who were drug treatment naive (N- group; n = 204). In the evaluable population donepezil improved MMSE scores by 2.21 +/- 3.47 points on average, with similar improvements observed in all three groups. QoL was judged to be improved in at least 70% of patients, again with similar results obtained for all three groups. Donepezil was well tolerated, with 85 of 913 (9.3%) patients reporting AEs. The most common AEs were those typically seen with cholinergic therapies (i.e., diarrhoea, vomiting and nausea). In this observational PMS study, donepezil was shown to be efficacious and well tolerated in patients who were being insufficiently treated with memantine or nootropic therapy. The magnitude of response was similar to that observed in patients who were previously

  9. Sunburn and sun-protective behaviors among adults with and without previous nonmelanoma skin cancer (NMSC): A population-based study.

    Science.gov (United States)

    Fischer, Alexander H; Wang, Timothy S; Yenokyan, Gayane; Kang, Sewon; Chien, Anna L

    2016-08-01

    Individuals with previous nonmelanoma skin cancer (NMSC) are at increased risk for subsequent skin cancer, and should therefore limit ultraviolet exposure. We sought to determine whether individuals with previous NMSC engage in better sun protection than those with no skin cancer history. We pooled self-reported data (2005 and 2010 National Health Interview Surveys) from US non-Hispanic white adults (758 with and 34,161 without previous NMSC). We calculated adjusted prevalence odds ratios (aPOR) and 95% confidence intervals (CI), taking into account the complex survey design. Individuals with previous NMSC versus no history of NMSC had higher rates of frequent use of shade (44.3% vs 27.0%; aPOR 1.41; 95% CI 1.16-1.71), long sleeves (20.5% vs 7.7%; aPOR 1.55; 95% CI 1.21-1.98), a wide-brimmed hat (26.1% vs 10.5%; aPOR 1.52; 95% CI 1.24-1.87), and sunscreen (53.7% vs 33.1%; aPOR 2.11; 95% CI 1.73-2.59), but did not have significantly lower odds of recent sunburn (29.7% vs 40.7%; aPOR 0.95; 95% CI 0.77-1.17). Among those with previous NMSC, recent sunburn was inversely associated with age, sun avoidance, and shade but not sunscreen. Self-reported cross-sectional data and unavailable information quantifying regular sun exposure are limitations. Physicians should emphasize sunburn prevention when counseling patients with previous NMSC, especially younger adults, focusing on shade and sun avoidance over sunscreen. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  10. Monte Carlo Simulations Validation Study: Vascular Brachytherapy Beta Sources

    International Nuclear Information System (INIS)

    Orion, I.; Koren, K.

    2004-01-01

    During the last decade many versions of angioplasty irradiation treatments have been proposed. The purpose of this unique brachytherapy is to administer a sufficient radiation dose into the vein walls in order to prevent restonosis, a clinical sequel to balloon angioplasty. The most suitable sources for this vascular brachytherapy are the β - emitters such as Re-188, P-32, and Sr-90/Y-90, with a maximum energy range of up to 2.1 MeV [1,2,3]. The radioactive catheters configurations offered for these treatments can be a simple wire [4], a fluid filled balloon or a coated stent. Each source is differently positioned inside the blood vessel, and the emitted electrons ranges therefore vary. Many types of sources and configurations were studied either experimentally or with the use of the Monte Carlo calculation technique, while most of the Monte Carlo simulations were carried out using EGS4 [5] or MCNP [6]. In this study we compared the beta-source absorbed-dose versus radial-distance of two treatment configurations using MCNP and EGS4 simulations. This comparison was aimed to discover the differences between the MCNP and the EGS4 simulation code systems in intermediate energies electron transport

  11. Open source drug discovery in practice: a case study.

    Science.gov (United States)

    Årdal, Christine; Røttingen, John-Arne

    2012-01-01

    Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD) and The Synaptic Leap's Schistosomiasis project (TSLS). Data were gathered from four sources: interviews of participating members (n = 14), a survey of potential members (n = 61), an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline) before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high quality research at low cost. The critical success factors appear to be clearly

  12. Open Source Drug Discovery in Practice: A Case Study

    Science.gov (United States)

    Årdal, Christine; Røttingen, John-Arne

    2012-01-01

    Background Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. Methodology/Principal Findings A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD) and The Synaptic Leap's Schistosomiasis project (TSLS). Data were gathered from four sources: interviews of participating members (n = 14), a survey of potential members (n = 61), an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline) before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. Conclusions/Significance Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high quality

  13. Experimental study on source efficiencies for estimating surface contamination level

    International Nuclear Information System (INIS)

    Ichiji, Takeshi; Ogino, Haruyuki

    2008-01-01

    Source efficiency was measured experimentally for various materials, such as metals, nonmetals, flooring materials, sheet materials and other materials, contaminated by alpha and beta emitter radioactive nuclides. Five nuclides, 147 Pm, 60 Co, 137 Cs, 204 Tl and 90 Sr- 90 Y, were used as the beta emitters, and one nuclide 241 Am was used as the alpha emitter. The test samples were prepared by placing drops of the radioactive standardized solutions uniformly on the various materials using an automatic quantitative dispenser system from Musashi Engineering, Inc. After placing drops of the radioactive standardized solutions, the test materials were allowed to dry for more than 12 hours in a draft chamber with a hood. The radioactivity of each test material was about 30 Bq. Beta rays or alpha rays from the test materials were measured with a 2-pi gas flow proportional counter from Aloka Co., Ltd. The source efficiencies of the metals, nonmetals and sheet materials were higher than 0.5 in the case of contamination by the 137 Cs, 204 Tl and 90 Sr- 90 Y radioactive standardized solutions, higher than 0.4 in the case of contamination by the 60 Co radioactive standardized solution, and higher than 0.25 in the case of contamination by the alpha emitter the 241 Am radioactive standardized solution. These values were higher than those given in Japanese Industrial Standards (JIS) documents. In contrast, the source efficiencies of some permeable materials were lower than those given in JIS documents, because source efficiency varies depending on whether the materials or radioactive sources are wet or dry. This study provides basic data on source efficiency, which is useful for estimating the surface contamination level of materials. (author)

  14. Studies of electron cyclotron resonance ion source plasma physics

    International Nuclear Information System (INIS)

    Tarvainen, O.

    2005-01-01

    This thesis consists of an introduction to the plasma physics of electron cyclotron resonance ion sources (ECRIS) and a review of the results obtained by the author and co-workers including discussion of related work by others. The thesis begins with a theoretical discussion dealing with plasma physics relevant for the production of highly charged ions in ECR ion source plasmas. This is followed by an overview of different techniques, such as gas mixing and double frequency heating, that can be used to improve the performance of this type of ion source. The experimental part of the work consists of studies related to ECRIS plasma physics. The effect of the gas mixing technique on the production efficiency of different ion beams was studied with both gaseous and solid materials. It was observed that gas mixing improves the confinement of the heavier element while the confinement of the lighter element is reduced. When the effect of gas mixing on MIVOC-plasmas was studied with several mixing gases it was observed that applying this technique can reduce the inevitable carbon contamination by a significant factor. In order to understand the different plasma processes taking place in ECRIS plasmas, a series of plasma potential and emittance measurements was carried out. An instrument, which can be used to measure the plasma potential in a single measurement without disturbing the plasma, was developed for this work. Studying the plasma potential of ECR ion sources is important not only because it helps to understand different plasma processes, but also because the information can be used as an input parameter for beam transport simulations and ion source extraction design. The experiments performed have revealed clear dependencies of the plasma potential on certain source parameters such as the amount of carbon contamination accumulated on the walls of the plasma chamber during a MIVOC-run. It was also observed that gas mixing affects not only the production efficiency

  15. Sources for comparative studies of placentation I. Embryological collections

    DEFF Research Database (Denmark)

    Carter, Anthony Michael

    2008-01-01

    A rich source of material for comparative studies of the placenta is the collections made by pioneers in the field such as H.W. Mossman, A.A.W. Hubrecht and J.P. Hill. This overview gives a brief description of collections known to be available and information on how each can be accessed. Include...... are some of the major series of human and animal embryos, such as the Boyd and Carnegie collections, as these also house placental material....

  16. French studies for improvement of the data for radioactive sources

    International Nuclear Information System (INIS)

    Duchemin, B.; Nimal, B.; Nimal, J.C.; Blachot, J.; Chouha, M.

    1988-01-01

    The 1987 version of the CEA radioactivity data bank is just distributed. This data bank is used to compute concentrations, activities, β and γ spectra, which give sources for shielding purposes. To improve this data bank at short cooling time (t < 200 sec) a methodology based on the statistical model is used to take account of the upper unknown levels. To give an example of the results we get, a brief summary of the studies we made for the TCHERNOBYL case is given

  17. A cross-sectional study of 'yaws' in districts of Ghana which have previously undertaken azithromycin mass drug administration for trachoma control.

    Directory of Open Access Journals (Sweden)

    Rosanna Ghinai

    2015-01-01

    Full Text Available Yaws, caused by Treponema pallidum ssp. pertenue, is reportedly endemic in Ghana. Mass distribution of azithromycin is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of azithromycin at a lower target dose was previously undertaken in two regions of Ghana for the control of trachoma. Ongoing reporting of yaws raises the possibility that resistance may have emerged in T. pallidum pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for trachoma had previously been conducted. Children aged 5-17 years with ulcerative lesions compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all children. 90 children with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for T. pallidum ssp pertenue was negative in all children, but Haemophilus ducreyi DNA was detected in 9 lesions. In these communities, previously treated for trachoma, we found no evidence of ongoing transmission of yaws. H. ducreyi was associated with a proportion of skin lesions, but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post-MDA surveillance systems is required to better inform yaws control programmes.

  18. Source study of the Jan Mayen transform fault strike-slip earthquakes

    Science.gov (United States)

    Rodríguez-Pérez, Q.; Ottemöller, L.

    2014-07-01

    Seismic source parameters of oceanic transform zone earthquakes have been relatively poorly studied. Previous studies showed that this type of earthquakes has unique characteristics such as not only the relatively common occurrence of slow events with weak seismic radiation at high frequencies but also the occurrence of some events that have high apparent stress indicating strong high frequency radiation. We studied 5 strike-slip earthquakes in the Jan Mayen fracture zone with magnitudes in the range of 5.9 centroid time delay compared to other oceanic transform fault earthquakes.

  19. High flux isotope reactor cold source preconceptual design study report

    International Nuclear Information System (INIS)

    Selby, D.L.; Bucholz, J.A.; Burnette, S.E.

    1995-12-01

    In February 1995, the deputy director of Oak Ridge National Laboratory (ORNL) formed a group to examine the need for upgrades to the High Flux Isotope Reactor (HFIR) system in light of the cancellation of the Advanced Neutron Source Project. One of the major findings of this study was that there was an immediate need for the installation of a cold neutron source facility in the HFIR complex. The anticipated cold source will consist of a cryogenic LH 2 moderator plug, a cryogenic pump system, a refrigerator that uses helium gas as a refrigerant, a heat exchanger to interface the refrigerant with the hydrogen loop, liquid hydrogen transfer lines, a gas handling system that includes vacuum lines, and an instrumentation and control system to provide constant system status monitoring and to maintain system stability. The scope of this project includes the development, design, safety analysis, procurement/fabrication, testing, and installation of all of the components necessary to produce a working cold source within an existing HFIR beam tube. This project will also include those activities necessary to transport the cold neutron beam to the front face of the present HFIR beam room. The cold source project has been divided into four phases: (1) preconceptual, (2) conceptual design and research and development (R and D), (3) detailed design and procurement, and (4) installation and operation. This report marks the conclusion of the preconceptual phase and establishes the concept feasibility. The information presented includes the project scope, the preliminary design requirements, the preliminary cost and schedule, the preliminary performance data, and an outline of the various plans for completing the project

  20. Polarization Study for NLC Positron Source Using EGS4

    Energy Technology Data Exchange (ETDEWEB)

    Liu, James C

    2000-09-20

    SLAC is exploring a polarized positron source to study new physics for the NLC project. The positron source envisioned in this paper consists of a polarized electron source, a 50-MeV electron accelerator, a thin target less-than-or-equal-to 0.2 radiation length for positron production, and a capture system for high-energy, small angular divergence positrons. The EGS4 code was used to study the yield, energy spectra, emission-angle distribution, and the mean polarization of the positrons emanating from W-Re and Ti targets hit by longitudinally polarized electron and photon beams. To account for polarization within the EGS4 code a method devised by Flottmann was used, which takes into account polarization transfer for pair production, bremsstrahlung, and Compton interactions. A mean polarization of 0.85 for positrons with energies greater than 25 MeV was obtained. Most of the high-energy positrons were emitted within a forward angle of 20 degrees. The yield of positrons above 25 MeV per incident photon was 0.034, which was about 70 times higher than that obtained with an electron beam.

  1. Study of spear as a dedicated source of synchrotron radiation

    International Nuclear Information System (INIS)

    Cerino, J.; Golde, A.; Hastings, J.; Lindau, I.; Salsburg, B.; Winick, H.; Lee, M.; Morton, P.; Garren, A.

    1977-11-01

    A study was made of the potential of SPEAR as a dedicated source of synchrotron radiation, based on the expectation that SPEAR will become increasingly available for this purpose as PEP, the 18-GeV colliding-beam storage ring now under construction by LBL and SLAC, becomes operational. A synchrotron radiation research program has been underway since May, 1974. Two beam ports capable of serving 9 simultaneous users are now operational. In single-beam multi-bunch operation high currents are possible (225 mA has been achieved and > approximately 300 mA is expected) and the electron beam emittance can be made smaller, resulting in higher source point brightness. Descriptions are given of SPEAR capabilities and of plans to expand the research capability by adding beam runs and by inserting wiggler magnets in SPEAR straight sections

  2. Beam Collimation Studies for the ILC Positron Source

    Energy Technology Data Exchange (ETDEWEB)

    Drozhdin, A.; /Fermilab; Nosochkov, Y.; Zhou, F.; /SLAC

    2008-06-26

    Results of the collimation studies for the ILC positron source beam line are presented. The calculations of primary positron beam loss are done using the ELEGANT code. The secondary positron and electron beam loss, the synchrotron radiation along the beam line and the bremsstrahlung radiation in the collimators are simulated using the STRUCT code. The first part of the collimation system, located right after the positron source target (0.125 GeV), is used for protection of the RF Linac sections from heating and radiation. The second part of the system is used for final collimation before the beam injection into the Damping Ring at 5 GeV. The calculated power loss in the collimation region is within 100 W/m, with the loss in the collimators of 0.2-5 kW. The beam transfer efficiency from the target to the Damping Ring is 13.5%.

  3. The advanced neutron source facility: Safety philosophy and studies

    International Nuclear Information System (INIS)

    Greene, S.R.; Harrington, R.M.

    1988-01-01

    The Advanced Neutron Source (ANS) is currently the only new civilian nuclear reactor facility proposed for construction in the United States. Even though the thermal power of this research-oriented reactor is a relatively low 300 MW, the design will undoubtedly receive intense scrutiny before construction is allowed to proceed. Safety studies are already under way to ensure that the maximum degree of safety in incorporated into the design and that the design is acceptable to the Department of Energy (DOE) and can meet the Nuclear Regulatory Commission regulations. This document discusses these safety studies

  4. A radio and optical study of Molonglo radio sources

    Science.gov (United States)

    Ishwara-Chandra, C. H.; Saikia, D. J.; McCarthy, P. J.; van Breugel, W. J. M.

    2001-05-01

    We present multi-wavelength radio observations with the Very Large Array, and narrow- and broad-band optical observations with the 2.5-m telescope at the Las Campanas Observatory, of a well-defined sample of high-luminosity Fanaroff-Riley class II radio galaxies and quasars, selected from the Molonglo Reference Catalogue 1-Jy sample. These observations were carried out as part of a programme to investigate the effects of orientation and environment on some of the observed properties of these sources. We examine the dependence of the Liu-Pooley relationship, which shows that radio lobes with flatter radio spectra are less depolarized, on size, identification and redshift, and show that it is significantly stronger for smaller sources, with the strength of the relationship being similar for both radio galaxies and quasars. In addition to Doppler effects, there appear to be intrinsic differences between the lobes on opposite sides. We discuss the asymmetry in brightness and location of the hotspots, and present estimates of the ages and velocities from matched-resolution observations in the L and C bands. Narrow- and broad-band optical images of some of these sources were made to study their environments and correlate with the symmetry parameters. An extended emission-line region is seen in a quasar, and in four of the objects possible companion galaxies are seen close to the radio axis.

  5. Isotope studies of UK tufa deposits and associated source waters

    International Nuclear Information System (INIS)

    Thorpe, P.M.

    1981-12-01

    Tufa is a secondary deposit of calcium carbonate precipitated from springs and streams. Previous attempts to date tufa deposits directly with 14 C have had limited success. The major problem is to quantify the amount of carbon incorporated in tufa, derived from the dissolution of carbonate bedrock, essentially free of 14 C. The isotopic composition of tufa-depositing streamwaters is similar to that of water recharging aquifers. The 14 C levels of recent tufa layers, at three sites, were similar to those of the source waters. 14 C dates from tufa at these sites suggested a Postglacial origin when corrected for bedrock carbon dilution of 16 to 24%. This dilution was overestimated by consideration of carbon mass balance using characteristic stable carbon isotope compositions (delta 13 C) for the biogenic and bedrock components. This method of correction is often applied to 14 C dates from groundwaters. The carbon isotope composition of spring waters supplying the tufa-depositing streams was realistically explained by a two stage process of carbonate dissolution under open and then closed conditions with respect to gaseous carbon dioxide. Seasonal variations in the 14 C and delta 13 C composition of stream and spring waters, downstream increases in 14 C and delta 13 C and seasonal variations in the oxygen and hydrogen isotopic composition of rainfall are explained. (author)

  6. Linac Coherent Light Source (LCLS) Design Study Report

    Energy Technology Data Exchange (ETDEWEB)

    Cornacchia, Massimo

    1998-12-04

    The Stanford Linear Accelerator Center, in collaboration with Los Alamos National Laboratory, Lawrence Livermore National Laboratory, and the University of California at Los Angeles, is proposing to build a Free-Electron-Laser (FEL) R and D facility operating in the wavelength range 1.5-15 {angstrom}. This FEL, called the ''Linac Coherent Light Source'' (LCLS), utilizes the SLAC linac and produces sub-picosecond pulses of short wavelength x-rays with very high peak brightness and full transverse coherence. Starting in FY 1998, the first two-thirds of the SLAC linac will be used for injection into the B factory. This leaves the last one-third free for acceleration to 15 GeV. The LCLS takes advantage of this opportunity, opening the way for the next generation of synchrotron light sources with largely proven technology and cost effective methods. This proposal is consistent with the recommendations of the Report of the Basic Energy Sciences Advisory Committee (Synchrotron Radiation Light Source Working Group, October 18-19, 1997). The report recognizes that ''fourth-generation x-ray sources...will in all likelihood be based on the free electron laser concepts. If successful, this technology could yield improvements in brightness by many orders of magnitude.'' This Design Study, the authors believe, confirms the feasibility of constructing an x-ray FEL based on the SLAC linac. Although this design is based on a consistent and feasible set of parameters, some components require more research and development to guarantee the performance. Given appropriate funding, this R and D phase can be completed in 2 years.

  7. Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study

    Directory of Open Access Journals (Sweden)

    Lopez-Saura Pedro

    2009-07-01

    Full Text Available Abstract Background Aggressive non-melanoma skin cancer (deeply infiltrating, recurrent, and morphea form lesions are therapeutically challenging because they require considerable tissue loss and may demand radical disfiguring surgery. Interferons (IFN may provide a non-surgical approach to the management of these tumors. The aim of this work was to evaluate the effect of a formulation containing IFNs-α and -γ in synergistic proportions on patients with recurrent, advanced basal cell (BCC or squamous cell skin carcinomas (SCSC. Methods Patients with extensive, recurrent, resistant to other procedures BCC or SCSC received the IFN formulation peri- and intralesionally, three times per week for 3 weeks. They had been previously treated with surgery and/or radiotherapy or chemotherapy. Thirteen weeks after the end of treatment, the original lesion sites were examined for histological evidence of remaining tumor. Results Sixteen elder (median 70 years-old patients were included. They beared 12 BCC and 4 SCSC ranging from 1.5 to 12.5 cm in the longest dimension. At the end of treatment 47% CR (complete tumor elimination, 40% PR (>30% tumor reduction, and 13% stable disease were obtained. None of the patients relapsed during the treatment period. The median duration of the response was 38 months. Only one patient with complete response had relapsed until today. Principal adverse reactions were influenza-like symptoms well known to occur with interferon therapy, which were well tolerated. Conclusion The peri- and intralesional combination of IFNs-α and -γ was safe and showed effect for the treatment of advanced, recurrent and resistant to previous treatments of BCC and SCSC in elder patients. This is the first report of such treatment in patients with advance non-melanoma skin cancer. The encouraging result justifies further confirmatory trials. Trial registration Current Controlled Trials RPCEC00000052.

  8. Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study

    International Nuclear Information System (INIS)

    Anasagasti-Angulo, Lorenzo; Garcia-Vega, Yanelda; Barcelona-Perez, Silvia; Lopez-Saura, Pedro; Bello-Rivero, Iraldo

    2009-01-01

    Aggressive non-melanoma skin cancer (deeply infiltrating, recurrent, and morphea form lesions) are therapeutically challenging because they require considerable tissue loss and may demand radical disfiguring surgery. Interferons (IFN) may provide a non-surgical approach to the management of these tumors. The aim of this work was to evaluate the effect of a formulation containing IFNs-α and -γ in synergistic proportions on patients with recurrent, advanced basal cell (BCC) or squamous cell skin carcinomas (SCSC). Patients with extensive, recurrent, resistant to other procedures BCC or SCSC received the IFN formulation peri- and intralesionally, three times per week for 3 weeks. They had been previously treated with surgery and/or radiotherapy or chemotherapy. Thirteen weeks after the end of treatment, the original lesion sites were examined for histological evidence of remaining tumor. Sixteen elder (median 70 years-old) patients were included. They beared 12 BCC and 4 SCSC ranging from 1.5 to 12.5 cm in the longest dimension. At the end of treatment 47% CR (complete tumor elimination), 40% PR (>30% tumor reduction), and 13% stable disease were obtained. None of the patients relapsed during the treatment period. The median duration of the response was 38 months. Only one patient with complete response had relapsed until today. Principal adverse reactions were influenza-like symptoms well known to occur with interferon therapy, which were well tolerated. The peri- and intralesional combination of IFNs-α and -γ was safe and showed effect for the treatment of advanced, recurrent and resistant to previous treatments of BCC and SCSC in elder patients. This is the first report of such treatment in patients with advance non-melanoma skin cancer. The encouraging result justifies further confirmatory trials. Current Controlled Trials RPCEC00000052

  9. Linac design study for an intense neutron-source driver

    International Nuclear Information System (INIS)

    Lynch, M.T.; Browman, A.; DeHaven, R.; Jameson, R.; Jason, A.; Neuschaefer, G.; Tallerico, P.; Regan, A.

    1993-01-01

    The 1-MW spallation-neutron source under design study at Los Alamos is driven by a linac-compressor-ring scheme that utilizes a large portion of the existing Los Alamos Meson Physics Facility (LAMPF) linac, as well as the facility infrastructure. The project is referred to as the National Center for Neutron Research (NCNR). A second phase of the proposal will upgrade the driver power to 5 MW. A description of the 1-MW scheme is given in this paper. In addition, the upgrade path to the substantial increase of beam power required for the 5 MW scenario is discussed

  10. Study of phenol extraction from coke-chemical sources

    Energy Technology Data Exchange (ETDEWEB)

    Catana, E.; Mateescu, I.; Giurcaneanu, V.; Bota, T.

    1990-09-01

    The paper presents an experimental study of the phase equilibrium in the coke-chemical tarphenols-solvent system (NaOH) solution and (phenolate solution) implied in the extraction of the phenols from coke-chemical sources. The possibility of using the phenolate solution as an extraction agent, thus making possible the improvement of the specific consumption and also simplifying the problem of the corrosion and of the waste water at the same time is presented. The influence of the solvent tar mass ratio on the selectivity of the process is discussed, this criterion being considered for establishing the conditions of the extraction. 2 figs., 7 tabs., 13 refs.

  11. Ground-source heat pump case studies and utility programs

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, P.J.; Boyd, T.L.; Rogers, R.L.

    1995-04-01

    Ground-source heat pump systems are one of the promising new energy technologies that has shown rapid increase in usage over the past ten years in the United States. These systems offer substantial benefits to consumers and utilities in energy (kWh) and demand (kW) savings. The purpose of this study was to determine what existing monitored data was available mainly from electric utilities on heat pump performance, energy savings and demand reduction for residential, school and commercial building applications. In order to verify the performance, information was collected for 253 case studies from mainly utilities throughout the United States. The case studies were compiled into a database. The database was organized into general information, system information, ground system information, system performance, and additional information. Information was developed on the status of demand-side management of ground-source heat pump programs for about 60 electric utility and rural electric cooperatives on marketing, incentive programs, barriers to market penetration, number units installed in service area, and benefits.

  12. Prognostic factors in multiple myeloma: definition of risk groups in 410 previously untreated patients: a Grupo Argentino de Tratamiento de la Leucemia Aguda study.

    Science.gov (United States)

    Corrado, C; Santarelli, M T; Pavlovsky, S; Pizzolato, M

    1989-12-01

    Four hundred ten previously untreated multiple myeloma patients entered onto two consecutive Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA) protocols were analyzed to identify significant prognostic factors influencing survival. The univariate analysis selected the following variables: performance status, renal function, percentage of bone marrow plasma cells at diagnosis, hemoglobin, and age. A multivariate analysis showed that performance status, renal function, percentage of bone marrow plasma cells, hemoglobin, and age were the best predictive variables for survival. A score was assigned to each patient according to these variables, which led to their classification in three groups: good, intermediate, and poor risk, with a probability of survival of 26% and 10% at 96 months, and 5% at 56 months, and median survival of 60, 37, and 14 months, respectively (P = .0000). In our patient population, this model proved to be superior to the Durie-Salmon staging system in defining prognostic risk groups, and separating patients with significantly different risks within each Durie-Salmon stage.

  13. Implementation of an electronic medical record system in previously computer-naïve primary care centres: a pilot study from Cyprus.

    Science.gov (United States)

    Samoutis, George; Soteriades, Elpidoforos S; Kounalakis, Dimitris K; Zachariadou, Theodora; Philalithis, Anastasios; Lionis, Christos

    2007-01-01

    The computer-based electronic medical record (EMR) is an essential new technology in health care, contributing to high-quality patient care and efficient patient management. The majority of southern European countries, however, have not yet implemented universal EMR systems and many efforts are still ongoing. We describe the development of an EMR system and its pilot implementation and evaluation in two previously computer-naïve public primary care centres in Cyprus. One urban and one rural primary care centre along with their personnel (physicians and nurses) were selected to participate. Both qualitative and quantitative evaluation tools were used during the implementation phase. Qualitative data analysis was based on the framework approach, whereas quantitative assessment was based on a nine-item questionnaire and EMR usage parameters. Two public primary care centres participated, and a total often health professionals served as EMR system evaluators. Physicians and nurses rated EMR relatively highly, while patients were the most enthusiastic supporters for the new information system. Major implementation impediments were the physicians' perceptions that EMR usage negatively affected their workflow, physicians' legal concerns, lack of incentives, system breakdowns, software design problems, transition difficulties and lack of familiarity with electronic equipment. The importance of combining qualitative and quantitative evaluation tools is highlighted. More efforts are needed for the universal adoption and routine use of EMR in the primary care system of Cyprus as several barriers to adoption exist; however, none is insurmountable. Computerised systems could improve efficiency and quality of care in Cyprus, benefiting the entire population.

  14. Feasibility study of a 1-MW pulsed spallation source

    International Nuclear Information System (INIS)

    Cho, Y.; Chae, Y.C.; Crosbie, E.

    1995-01-01

    A feasibility study of a 1-MW pulsed spallation source based on a rapidly cycling proton synchrotron (RCS) has been completed. The facility consists of a 400-MeV HP - linac, a 30-Hz RCS that accelerates the 400-MeV beam to 2 GeV, and two neutron-generating target stations. The design time-averaged current of the accelerator system is 0.5 mA, or 1.04x1014 protons per pulse. The linac system consists of an H - ion source, a 2-MeV RFQ, a 70-MeV DTL and a 330-MeV CCL. Transverse phase space painting to achieve a Kapchinskij-Vladimirskij (K-V) distribution of the injected particles in the RCS is accomplished by charge exchange injection and programming of the closed orbit during injection. The synchrotron lattice uses FODO cells of ∼90 degrees phase advance. Dispersion-free straight sections are obtained by using a missing magnet scheme. Synchrotron magnets are powered by a dual-frequency resonant circuit that excites the magnets at a 20-Hz rate and de-excites them at a 60-Hz rate, resulting in an effective rate of 30 Hz, and reducing the required peak rf voltage by 1/3. A key feature, of the design of this accelerator system is that beam losses are from injection to extraction, reducing activation to levels consistent with hands-on maintenance. Details of the study are presented

  15. Preliminary studies of Brazilian wood using different radioisotopic sources

    International Nuclear Information System (INIS)

    Carvalho, Gilberto; Silva, Leonardo Gondim de Andrade e

    2013-01-01

    Due to availability and particular features, wood was one of the first materials used by mankind with a wide variety of applications. It can be used as raw material for paper and cellulose manufacturing; in industries such as chemical, naval, furniture, sports goods, toys, and musical instrument; in building construction and in the distribution of electric energy. Wood has been widely researched; therefore, wood researchers know that several aspects such as temperature, latitude, longitude, altitude, sunlight, soil, and rainfall index interfere with the growth of trees. This behavior explains why average physical-chemical properties are important when wood is studied. The majority of researchers consider density to be the most important wood property because of its straight relationship with the physical and mechanical properties of wood. There are three types of wood density: basic, apparent and green. The apparent density was used here at 12% of moisture content. In this study, four different types of wood were used: 'freijo', 'jequetiba', 'muiracatiara' and 'ipe'. For wood density determination by non-conventional method, Am-241, Ba-133 and Cs-137 radioisotopic sources; a NaI scintillation detector and a counter were used. The results demonstrated this technique to be quick and accurate. By considering the nuclear parameters obtained as half value layers and linear absorption coefficients, Cs-137 radioisotopic source demonstrated to be the best option to be used for inspection of the physical integrity of electric wooden poles and live trees for future works. (author)

  16. Prospective monitoring and self-report of previous falls among older women at high risk of falls and fractures: a study of comparison and agreement.

    Science.gov (United States)

    Garcia, Patrícia A; Dias, João M D; Silva, Silvia L A; Dias, Rosângela C

    2015-01-01

    The identification of the occurrence of falls is an important step for screening and for rehabilitation processes for the elderly. The methods of monitoring these events are susceptible to recording biases, and the choice of the most accurate method remains challenging. (i) To investigate the agreement between retrospective self-reporting and prospective monitoring of methods of recording falls, and (ii) to compare the retrospective self-reporting of falls and the prospective monitoring of falls and recurrent falls over a 12-month period among older women at high risk of falls and fractures. A total of 118 community-dwelling older women with low bone density were recruited. The incidence of falls was monitored prospectively in 116 older women (2 losses) via monthly phone calls over the course of a year. At the end of this monitoring period, the older women were asked about their recall of falls in the same 12-month period. The agreement between the two methods was analyzed, and the sensitivity and specificity of self-reported previous falls in relation to the prospective monitoring were calculated. There was moderate agreement between the prospective monitoring and the retrospective self-reporting of falls in classifying fallers (Kappa = 0.595) and recurrent fallers (Kappa = 0.589). The limits of agreement were 0.35 ± 1.66 falls. The self-reporting of prior falls had a 67.2% sensitivity and a 94.2% specificity in classifying fallers among older women and a 50% sensitivity and a 98.9% specificity in classifying recurrent fallers. Self-reporting of falls over a 12-month period underestimated 32.8% of falls and 50% of recurrent falls. The findings recommend caution if one is considering replacing monthly monitoring with annual retrospective questioning.

  17. The importance of continued exercise participation in quality of life and psychological well-being in previously inactive postmenopausal women: a pilot study.

    Science.gov (United States)

    Asbury, Elizabeth A; Chandrruangphen, Pornpat; Collins, Peter

    2006-01-01

    Exercise and physical activity provide a wide range of health benefits for postmenopausal women, although the impact of maintained exercise participation on psychological well-being is unclear. An exploration of continued exercise participation in psychological well-being after a moderate-intensity exercise program in previously inactive postmenopausal women was therefore undertaken. : Twenty-three healthy sedentary postmenopausal women (age 56 +/- 4 years) were randomly assigned to two groups. All participants completed the Short Form-36, Hospital Anxiety and Depression Scale (HADS), and Health Anxiety Questionnaire (HAQ) and then began a 6-week walking program at 50% heart rate reserve defined by (.-)V(O(2)) treadmill testing. Post-intervention, all participants underwent (.-)V(O(2)) treadmill testing and questionnaires. Group 1 was then instructed to continue exercising, whereas group 2 was instructed to desist for an additional 6-week period. On completion of the 6-week follow-up, participants completed a final set of questionnaires. Participants performed 97% of the prescribed 15-hour (900 minute) exercise program (875.1 +/- 177.4 minutes) in an average of 26 +/- 5 sessions. Total HAQ (P = 0.001), health worry (P = 0.001), fear of illness (P = 0.037), reassurance seeking behavior (P = 0.037), SF-36 well-being (P = 0.037), total HADS (P = 0.019), and HADS depression (P = 0.015) improved significantly following the exercise program. At follow-up, group 1 had lower HADS anxiety (P = 0.013), total HADS (P = 0.02), total HAQ (P = 0.03), and HAQ interference with life (P = 0.03) and significantly higher SF-36 energy (P = 0.01) than group 2. Healthy postmenopausal women gain significant psychological benefit from moderate-intensity exercise. However, exercise participation must continue to maintain improvements in psychological well-being and quality of life.

  18. FEASIBILITY STUDY II OF A MUON BASED NEUTRINO SOURCE.

    Energy Technology Data Exchange (ETDEWEB)

    GALLARDO,J.C.; OZAKI,S.; PALMER,R.B.; ZISMAN,M.

    2001-06-30

    The concept of using a muon storage ring to provide a well characterized beam of muon and electron neutrinos (a Neutrino Factory) has been under study for a number of years now at various laboratories throughout the world. The physics program of a Neutrino Factoryis focused on the relatively unexplored neutrino sector. In conjunction with a detector located a suitable distance from the neutrino source, the facility would make valuable contributions to the study of neutrino masses and lepton mixing. A Neutrino Factory is expected to improve the measurement accuracy of sin{sup 2}(2{theta}{sub 23}) and {Delta}m{sup 2}{sub 32} and provide measurements of sin{sup 2}(2{theta}{sub 13}) and the sign of {Delta}m{sup 2}{sub 32}. It may also be able to measure CP violation in the lepton sector.

  19. Open-Source Software in Computational Research: A Case Study

    Directory of Open Access Journals (Sweden)

    Sreekanth Pannala

    2008-04-01

    Full Text Available A case study of open-source (OS development of the computational research software MFIX, used for multiphase computational fluid dynamics simulations, is presented here. The verification and validation steps required for constructing modern computational software and the advantages of OS development in those steps are discussed. The infrastructure used for enabling the OS development of MFIX is described. The impact of OS development on computational research and education in gas-solids flow, as well as the dissemination of information to other areas such as geophysical and volcanology research, is demonstrated. This study shows that the advantages of OS development were realized in the case of MFIX: verification by many users, which enhances software quality; the use of software as a means for accumulating and exchanging information; the facilitation of peer review of the results of computational research.

  20. Sources of International Courts' Legitimacy: A comparative study

    DEFF Research Database (Denmark)

    Godzimirska, Zuzanna; Creamer, Cosette

    Despite ample scholarship on the legitimacy of international legal institutions, existing studies on international courts (ICs) tend to adopt normative or deductive approaches to specify their legitimacy and assess its effects. Very few adopt empirical or inductive approaches and examine the reas......Despite ample scholarship on the legitimacy of international legal institutions, existing studies on international courts (ICs) tend to adopt normative or deductive approaches to specify their legitimacy and assess its effects. Very few adopt empirical or inductive approaches and examine...... the reasons why an IC is considered more or less legitimate in the eyes of a court’s constituents. This paper addresses this scholarly gap by identifying the sources of ICs’ legitimacy within the expressed views of one category of constituents: a court’s member states. Although we emphasize the importance...

  1. Feasibility study for the spallation neutron source (SNQ). Pt. 1

    International Nuclear Information System (INIS)

    Bauer, G.S.; Sebening, H.; Vetter, J.E.; Willax, H.

    1981-06-01

    A concept for a new neutron source for fundamental research has been developed and is described in this report. The spallation neutron source SNQ is characterized in its first stage by a time average thermal neutron flux of 7 x 10 14 cm -2 s -1 and a peak flux of 1.3 x 10 16 cm -2 s -1 at 100 Hz repetition rate. The scientific case is presented with particular emphasis on solid state and nuclear physics. In these research domains, unique conditions are given for experimental use. The proposed machine consists in its basic stage of a 1.1 GeV, 5 mA time average, 100 mA peak current proton linear accelerator, a rotating lead target, and H 2 O and D 2 O moderators. Additional beam channels are provided for experiments with protons at 350 MeV and at the final energy. Construction of the SNQ is considered feasible within eight years at a cost of 680 million DM. As future options, use of uranium as a target material, increase of the accelerator beam power by a factor of 2, addition of a pulse compressor and a second target station for pulsed neutron and neutrino research are described. As a back-up solution to the rotating target, a liquid metal target was studied. (orig.) [de

  2. FEL polarization control studies on Dalian coherent light source

    International Nuclear Information System (INIS)

    Zhang Tong; Deng Haixiao; Wang Dong; Zhao Zhentang; Zhang Weiqing; Wu Guorong; Dai Dongxu; Yang Xueming

    2013-01-01

    The polarization switch of a free-electron laser (FEL) is of great importance to the user scientific community. In this paper, we investigate the generation of controllable polarization FEL from two well-known approaches for Dalian coherent light source, i.e., crossed planar undulator and elliptical permanent undulator. In order to perform a fair comparative study, a one-dimensional time-dependent FEL code has been developed, in which the imperfection effects of an elliptical permanent undulator are taken into account. Comprehensive simulation results indicate that the residual beam energy chirp and the intrinsic FEL gain may contribute to the degradation of the polarization performance for the crossed planar undulator. The elliptical permanent undulator is not very sensitive to the undulator errors and beam imperfections. Meanwhile, with proper configurations of the main planar undulators and additional elliptical permanent undulator section, circular polarized FEL with pulse energy exceeding 100 μJ could be achieved at Dalian coherent light source. (authors)

  3. A New ECR Ion Source for Nuclear Astrophysics Studies

    Science.gov (United States)

    Cesaratto, John M.

    2008-10-01

    The Laboratory for Experimental Nuclear Astrophysics (LENA) is a low energy facility designed to study nuclear reactions of astrophysical interest at energies which are important for nucleosysthesis. In general, these reactions have extremely small cross sections, requiring intense beams and efficient detection systems. Recently, a new, high intensity electron-cyclotron-resonance (ECR) ion source has been constructed (based on a design by Wills et al.[1]), which represents a substantial improvement in the capabilities of LENA. Beam is extracted from an ECR plasma excited at 2.45 GHz and confined by an array of permanent magnets. It has produced H^+ beams in excess of 1 mA on target over the energy range 100 - 200 keV, which greatly increases our ability to measure small cross sections. Initial measurements will focus on the ^23Na(p,γ)^24Mg reaction, which is of interest in a variety of astrophysical scenarios. The present uncertainty in the rate of this reaction is the result of an unobserved resonance expected at Elab =144 keV, which should be detectable using beams from the new ECR source. In collaboration with Arthur E. Champagne and Thomas B. Clegg, University of North Carolina, Chapel Hill and TUNL. [3pt] [1] J. S. C. Wills et al., Rev. Sci. Instrum. 69, 65 (1999).

  4. Integrated source-risk model for radon: A definition study

    International Nuclear Information System (INIS)

    Laheij, G.M.H.; Aldenkamp, F.J.; Stoop, P.

    1993-10-01

    The purpose of a source-risk model is to support policy making on radon mitigation by comparing effects of various policy options and to enable optimization of counter measures applied to different parts of the source-risk chain. There are several advantages developing and using a source-risk model: risk calculations are standardized; the effects of measures applied to different parts of the source-risk chain can be better compared because interactions are included; and sensitivity analyses can be used to determine the most important parameters within the total source-risk chain. After an inventory of processes and sources to be included in the source-risk chain, the models presently available in the Netherlands are investigated. The models were screened for completeness, validation and operational status. The investigation made clear that, by choosing for each part of the source-risk chain the most convenient model, a source-risk chain model for radon may be realized. However, the calculation of dose out of the radon concentrations and the status of the validation of most models should be improved. Calculations with the proposed source-risk model will give estimations with a large uncertainty at the moment. For further development of the source-risk model an interaction between the source-risk model and experimental research is recommended. Organisational forms of the source-risk model are discussed. A source-risk model in which only simple models are included is also recommended. The other models are operated and administrated by the model owners. The model owners execute their models for a combination of input parameters. The output of the models is stored in a database which will be used for calculations with the source-risk model. 5 figs., 15 tabs., 7 appendices, 14 refs

  5. Sustainability in Open Source Software Commons: Lessons Learned from an Empirical Study of SourceForge Projects

    OpenAIRE

    Charles M. Schweik

    2013-01-01

    In this article, we summarize a five-year US National Science Foundation funded study designed to investigate the factors that lead some open source projects to ongoing collaborative success while many others become abandoned. Our primary interest was to conduct a study that was closely representative of the population of open source software projects in the world, rather than focus on the more-often studied, high-profile successful cases. After building a large database of projects (n=174,33...

  6. Obsidian sourcing studies in Papua New Guinea using PIXE-PIGME analysis

    International Nuclear Information System (INIS)

    Summerhayes, G.R.; Gosden, C.; Bird, R.; Hotchkis, M.; Specht, J.; Torrence, R.; Fullaga, R.

    1993-01-01

    Over 100 obsidian samples were analysed using PIXE-PIGME in 1990. These samples were collected during intensive surveys of the source areas around Talasea, Garua Island, and the Mopir area in 1988, 1989 and 1990. A ratio combination of 9 elements were used to separate out groups as per previous studies: F/Na, Al/Na, K/Fe, Ca/Fe, Mn/Fe, Rb/Fe, Y/Zr, Sr/Fe and Zr/Fe. In spite of variations in major elements, the close agreement between results for minor and trace elements concentrations in artefacts and known source material indicates that the provenance of each artefact can be reliably determined. This conclusion provides important validation of the use of ion beam analysis in artefact characterisation. ills

  7. Obsidian sourcing studies in Papua New Guinea using PIXE-PIGME analysis

    Energy Technology Data Exchange (ETDEWEB)

    Summerhayes, G R; Gosden, C [La Trobe Univ., Bundoora, VIC (Australia); Bird, R; Hotchkis, M [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia); Specht, J; Torrence, R; Fullaga, R [Australian Museum, Sydney, NSW (Australia). Div. of Anthropology

    1994-12-31

    Over 100 obsidian samples were analysed using PIXE-PIGME in 1990. These samples were collected during intensive surveys of the source areas around Talasea, Garua Island, and the Mopir area in 1988, 1989 and 1990. A ratio combination of 9 elements were used to separate out groups as per previous studies: F/Na, Al/Na, K/Fe, Ca/Fe, Mn/Fe, Rb/Fe, Y/Zr, Sr/Fe and Zr/Fe. In spite of variations in major elements, the close agreement between results for minor and trace elements concentrations in artefacts and known source material indicates that the provenance of each artefact can be reliably determined. This conclusion provides important validation of the use of ion beam analysis in artefact characterisation. ills.

  8. Obsidian sourcing studies in Papua New Guinea using PIXE-PIGME analysis

    Energy Technology Data Exchange (ETDEWEB)

    Summerhayes, G.R.; Gosden, C. [La Trobe Univ., Bundoora, VIC (Australia); Bird, R.; Hotchkis, M. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia); Specht, J.; Torrence, R.; Fullaga, R. [Australian Museum, Sydney, NSW (Australia). Div. of Anthropology

    1993-12-31

    Over 100 obsidian samples were analysed using PIXE-PIGME in 1990. These samples were collected during intensive surveys of the source areas around Talasea, Garua Island, and the Mopir area in 1988, 1989 and 1990. A ratio combination of 9 elements were used to separate out groups as per previous studies: F/Na, Al/Na, K/Fe, Ca/Fe, Mn/Fe, Rb/Fe, Y/Zr, Sr/Fe and Zr/Fe. In spite of variations in major elements, the close agreement between results for minor and trace elements concentrations in artefacts and known source material indicates that the provenance of each artefact can be reliably determined. This conclusion provides important validation of the use of ion beam analysis in artefact characterisation. ills.

  9. A study of the physico-chemical characteristics of a solid radon 222 source

    International Nuclear Information System (INIS)

    Chuiton, G.

    1990-01-01

    A solid radon 222 source is described; it is made of a manganese oxide impregnated acrylic felt disc on which radium 226 is fixed. The disc is incorporated into a scanning device allowing the passage through the felt of a radon 222 free gas (air or nitrogen) previously led to a relative humidity of air near to saturation. At the device outlet, a stable activity of radon 222 is obtained. The preparation, characteristics and radiochemical stability conditions of the 226 radium source are presented. Following a description of the scanning device, the radon 222 emanation coefficient is studied as a function of the relative humidity of air. The reliability of the device is assessed by an uncertainty calculation for the utilisation conditions recommended. Finally, an approach to the physico-chemical processes governing radon 222 emanation rate in the device is set forth [fr

  10. Positron annihilation lifetime spectroscopy source correction determination: A simulation study

    Energy Technology Data Exchange (ETDEWEB)

    Kanda, Gurmeet S.; Keeble, David J., E-mail: d.j.keeble@dundee.ac.uk

    2016-02-01

    Positron annihilation lifetime spectroscopy (PALS) can provide sensitive detection and identification of vacancy-related point defects in materials. These measurements are normally performed using a positron source supported, and enclosed by, a thin foil. Annihilation events from this source arrangement must be quantified and are normally subtracted from the spectrum before analysis of the material lifetime components proceeds. Here simulated PALS spectra reproducing source correction evaluation experiments have been systematically fitted and analysed using the packages PALSfit and MELT. Simulations were performed assuming a single lifetime material, and for a material with two lifetime components. Source correction terms representing a directly deposited source and various foil supported sources were added. It is shown that in principle these source terms can be extracted from suitably designed experiments, but that fitting a number of independent, nominally identical, spectra is recommended.

  11. The possibility of previous epidemiological data to serve as baseline for future national oral health surveys--a study in Vietnam.

    NARCIS (Netherlands)

    Palenstein Helderman, W.H. van; Truin, G.J.; Can, N.; Khanh, N.D.

    2001-01-01

    AIM: The purpose of this paper is to review the most recent epidemiological data (1985-2000) on dental caries and periodontal diseases in Vietnam in an attempt to obtain a 'baseline' for future national oral health surveys. METHODS: Studies on periodontal diseases and caries were included when CPITN

  12. Alfalfa (Medicago sativa L.) is tolerant to higher levels of salinity than previous guidelines indicated: Implications of field and greenhouse studies

    Science.gov (United States)

    Putnam, Daniel H.; Benes, Sharon; Galdi, Giuliano; Hutmacher, Bob; Grattan, Steve

    2017-04-01

    Alfalfa (Medicago sativa L.) is the most widely grown leguminous forage crop in North America and is valued for high productivity, quality, economic value, and for dairy productivity. Alfalfa has historically been classified as moderately sensitive to saline conditions, with yield declines predicted at >2 dS/m in the saturated soil paste extract. However, greenhouse, sand tank, and field studies over the past five years have confirmed that alfalfa can be grown with limited negative effects at much higher salinity levels. A broad collection of alfalfa varieties has exhibited a range of resistance at irrigation water salinities >5 dS/m ECw in greenhouse trials, with significant variation due to variety. USDA-ARS sand tank studies indicated similar or greater tolerances closer to 8 dS/m in the soil water, in addition to confirmation of significant varietal differences. A three-year field study on clay loam soil with applications of 5-7 dS/m ECw irrigation water indicated normal yields and excellent stand survivability. A second field study in the same soil type with levels from 8-10 dS/m ECw showed yield reductions of 10-15% but economic yields were still achieved at those levels. Field and greenhouse studies were conducted with mixed salt saline sodic waters typical of the San Joaquin Valley of California. Field evaluation of variety performance was subject to greater variation due to secondary salinity-soil interactions including water infiltration and crusting problems, not only salinity per-se. Thus, adequate irrigation water availability to the crop may be as important as salinity in impacting yields under field conditions. Once established, the deep-rooted characteristics of alfalfa enable utilization of deeper subsurface moisture, even at moderate to high salinity levels, as documented by USDA lysimeter studies. Significant advantages to salinity-tolerant varieties have been observed. It will be important to consider specific management factors which may enable

  13. Effect of benzalkonium chloride?free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study

    OpenAIRE

    Lopes, Joao F.; Hubatsch, Douglas A.; Amaris, Patricia

    2015-01-01

    Background Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK). Methods This was an open-label, single-arm study conducted in Latin America from February 2012 to May 2013. Patients with open-angle glaucoma or ocular hypertension who were intolerant of latanoprost 0.005?% were transitioned to recei...

  14. Preliminary studies of Brazilian wood using different radioisotopic sources

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Gilberto; Silva, Leonardo Gondim de Andrade e, E-mail: gcarval@ipen.br, E-mail: ftgasilva@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Due to availability and particular features, wood was one of the first materials used by mankind with a wide variety of applications. It can be used as raw material for paper and cellulose manufacturing; in industries such as chemical, naval, furniture, sports goods, toys, and musical instrument; in building construction and in the distribution of electric energy. Wood has been widely researched; therefore, wood researchers know that several aspects such as temperature, latitude, longitude, altitude, sunlight, soil, and rainfall index interfere with the growth of trees. This behavior explains why average physical-chemical properties are important when wood is studied. The majority of researchers consider density to be the most important wood property because of its straight relationship with the physical and mechanical properties of wood. There are three types of wood density: basic, apparent and green. The apparent density was used here at 12% of moisture content. In this study, four different types of wood were used: 'freijo', 'jequetiba', 'muiracatiara' and 'ipe'. For wood density determination by non-conventional method, Am-241, Ba-133 and Cs-137 radioisotopic sources; a NaI scintillation detector and a counter were used. The results demonstrated this technique to be quick and accurate. By considering the nuclear parameters obtained as half value layers and linear absorption coefficients, Cs-137 radioisotopic source demonstrated to be the best option to be used for inspection of the physical integrity of electric wooden poles and live trees for future works. (author)

  15. Comparative Analysis Study of Open Source GIS in Malaysia

    International Nuclear Information System (INIS)

    Rasid, Muhammad Zamir Abdul; Kamis, Naddia; Halim, Mohd Khuizham Abd

    2014-01-01

    Open source origin might appear like a major prospective change which is qualified to deliver in various industries and also competing means in developing countries. The leading purpose of this research study is to basically discover the degree of adopting Open Source Software (OSS) that is connected with Geographic Information System (GIS) application within Malaysia. It was derived based on inadequate awareness with regards to the origin ideas or even on account of techie deficiencies in the open origin instruments. This particular research has been carried out based on two significant stages; the first stage involved a survey questionnaire: to evaluate the awareness and acceptance level based on the comparison feedback regarding OSS and commercial GIS. This particular survey was conducted among three groups of candidates: government servant, university students and lecturers, as well as individual. The approaches of measuring awareness in this research were based on a comprehending signal plus a notion signal for each survey questions. These kinds of signs had been designed throughout the analysis in order to supply a measurable and also a descriptive signal to produce the final result. The second stage involved an interview session with a major organization that carries out available origin internet GIS; the Federal Department of Town and Country Planning Peninsular Malaysia (JPBD). The impact of this preliminary study was to understand the particular viewpoint of different groups of people on the available origin, and also their insufficient awareness with regards to origin ideas as well as likelihood may be significant root of adopting level connected with available origin options

  16. Effect of benzalkonium chloride-free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study.

    Science.gov (United States)

    Lopes, Joao F; Hubatsch, Douglas A; Amaris, Patricia

    2015-11-12

    Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK). This was an open-label, single-arm study conducted in Latin America from February 2012 to May 2013. Patients with open-angle glaucoma or ocular hypertension who were intolerant of latanoprost 0.005 % were transitioned to receive once-daily BAK-free travoprost 0.004 % containing polyquaternium-1 (Travatan® preserved with POLYQUAD® [PQ], Alcon Laboratories, Inc; Fort Worth, TX) for 12 weeks. Mean change in IOP from baseline (primary efficacy endpoint) and the percentage of patients who achieved a target IOP of ≤18 mmHg were evaluated at all on-therapy visits. Ocular hyperemia, patient preference, and self-projected adherence were assessed at week 12. Adverse events (AEs) were monitored throughout the study. All enrolled patients were included in the analysis (n = 191); the majority of patients (90.6 %, n = 173/191) completed the study. Mean (SD) patient age was 67.5 (11.3) years, and mean baseline IOP was 14.8 mmHg. Mean IOP was reduced by 0.94 mmHg at week 6 and by 1.09 mmHg at week 12 (P glaucoma or ocular hypertension who were intolerant of latanoprost. BAK-free travoprost 0.004 % is a viable alternative for patients who require switching their IOP-lowering medications because of tolerability issues. ClinicalTrials.gov identifier, NCT01510145.

  17. Does hyperbaric oxygen treatment have the potential to increase salivary flow rate and reduce xerostomia in previously irradiated head and neck cancer patients? A pilot study

    DEFF Research Database (Denmark)

    Forner, Lone; Hansen, Ole Hyldegaard; von Brockdorff, Annet Schack

    2011-01-01

    in irradiated head and neck cancer patients. Eighty patients eligible for HBO treatment on the indication of prevention/treatment of osteoradionecrosis or soft tissue radiation injury were consecutively sampled, of whom 45 had hyposalivation (i.e. unstimulated whole saliva (UWS) flow rate......Irradiated head and neck cancer survivors treated in the Hyperbaric Oxygen (HBO) Unit, Copenhagen University Hospital, spontaneously reported improvement of radiation-induced dry mouth feeling. The aim of this pilot study was to evaluate salivary flow rate and xerostomia before and after HBO...

  18. Previous study for the setting up and optimization of detection of ZnS(Ag) scintillation applied to the measure of alpha radioactivity index

    International Nuclear Information System (INIS)

    Pujol, L.; Suarez-Navarro, J.A.; Montero, M.

    1998-01-01

    The determination of radiological water quality is useful for a wide range of environmental studies. In these cases, the gross alpha activity is one of the parameters to determine. This parameter permits to decide if further radiological analyses are necessary in order to identify and quantify the presence of alpha emitters in water. The usual method for monitoring the gross alpha activity includes sample evaporation to dryness on a disk and counting using ZnS(Ag) scintillation detector. Detector electronics is provided with two components which are adjustable by the user the high-voltage applied to the photomultiplier tubes and the low level discriminator that is used to eliminate the electronic noise. The high-voltage and low level discriminator optimization are convenient in order to reach the best counting conditions. This paper is a preliminary study of the procedure followed for the setting up and optimization of the detector electronics in the laboratories of CEDEX for the measurement of gross alpha activity. (Author)

  19. [Mutations of resistance of HIV-1 in previously untreated patients at penitentiary centers of the Autonomous Community of Valencia, Spain. REPRICOVA study].

    Science.gov (United States)

    García-Guerrero, Julio; Herrero, Agustín; Vera, Enrique; Almenara, José M; Araújo, Rosa; Saurí, Vicente V; Castellano, Juan C; Fernández-Clemente, Luis; Bedia, Miguel; Llorente, María I; González-Morán, Francisco

    2002-03-02

    Our purpose was to determine the prevalence of mutations of resistance to nucleoside inhibitors of reverse transcriptase (NIRT) and protease inhibitors (PI) in the HIV-1 genotype of naïve infected subjects in the prisons of the Autonomous Community of Valencia, Spain. Multicentric, descriptive, cross-sectional study of prevalence including a systematic stratified and randomised sampling by centres. Demographic, clinical, virological and immunological data were collected. The HIV gene of protease and transcriptase was studied in peripheral blood plasma samples by means of double PCR amplification and subsequent automatic sequence. Reference: wild strain HXB2. Plasma was obtained from 133 individuals (119 men and 14 women). 117 samples were selected and the rest did not have enough copies for transcription. With regard to NIRT, 7 samples (5.2% of total) showed some mutation of resistance: M41L, D67N, L210W and K219Q, all them secondary to and associated with resistance to zidovudine, abacavir as well as group B multinucleoside-resistance. With regard to PI, only one sample showed a primary mutation, M46I, which was associated with resistance to indinavir. Moreover, a further 41 samples were found to express some secondary mutation. In our series, there was a low number of primary mutations of resistance. These results allow us to exclude the systematic use of resistance tests before an initiation antiretroviral therapy.

  20. In Vitro Fertilization Outcomes After Placement of Essure Microinserts in Patients With Hydrosalpinges Who Previously Failed In Vitro Fertilization Treatment: A Multicenter Study.

    Science.gov (United States)

    Cohen, Shlomo B; Bouaziz, Jerome; Schiff, Eyal; Simon, Alexander; Nadjary, Michel; Goldenberg, Mordechai; Orvieto, Raoul; Revel, Ariel

    2016-01-01

    To investigate whether hysteroscopic proximal tubal occlusion with Essure microinserts (Conceptus Inc.; Bayer, AG, North Rhine-Westphalia, Germany) can improve pregnancy rates in patients with hydrosalpinges who had failed in vitro fertilization (IVF) treatment. A prospective cohort study. University-affiliated tertiary centers. Twenty-four consecutive women with hydrosalpinges who had failed IVF treatment were included. Hysteroscopic placement of Essure microinserts for hydrosalpinx blockage followed by IVF treatment. Ongoing pregnancy and live birth rates were recorded. Of the 24 patients undergoing a total of 42 IVF cycles after Essure insertion, 18 (75% of patients and 42.8% of IVF cycle attempts) conceived and 16 delivered live births (66.6% of patients and 38.1% of IVF cycle attempts). Hysteroscopic proximal occlusion of hydrosalpinges with Essure microinserts is a valuable alternative to laparoscopic salpingectomy, resulting in reasonable pregnancy rates. Copyright © 2016 AAGL. Published by Elsevier Inc. All rights reserved.

  1. Kansas City Cardiomyopathy Questionnaire Score Is Associated With Incident Heart Failure Hospitalization in Patients With Chronic Kidney Disease Without Previously Diagnosed Heart Failure: Chronic Renal Insufficiency Cohort Study.

    Science.gov (United States)

    Mishra, Rakesh K; Yang, Wei; Roy, Jason; Anderson, Amanda H; Bansal, Nisha; Chen, Jing; DeFilippi, Christopher; Delafontaine, Patrice; Feldman, Harold I; Kallem, Radhakrishna; Kusek, John W; Lora, Claudia M; Rosas, Sylvia E; Go, Alan S; Shlipak, Michael G

    2015-07-01

    Chronic kidney disease is a risk factor for heart failure (HF). Patients with chronic kidney disease without diagnosed HF have an increased burden of symptoms characteristic of HF. It is not known whether these symptoms are associated with occurrence of new onset HF. We studied the association of a modified Kansas City Cardiomyopathy Questionnaire with newly identified cases of hospitalized HF among 3093 participants enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study who did not report HF at baseline. The annually updated Kansas City Cardiomyopathy Questionnaire score was categorized into quartiles (Q1-4) with the lower scores representing the worse symptoms. Multivariable-adjusted repeated measure logistic regression models were adjusted for demographic characteristics, clinical risk factors for HF, N-terminal probrain natriuretic peptide level and left ventricular hypertrophy, left ventricular systolic and diastolic dysfunction. Over a mean (±SD) follow-up period of 4.3±1.6 years, there were 211 new cases of HF hospitalizations. The risk of HF hospitalization increased with increasing symptom quartiles; 2.62, 1.85, 1.14, and 0.74 events per 100 person-years, respectively. The median number of annual Kansas City Cardiomyopathy Questionnaire assessments per participant was 5 (interquartile range, 3-6). The annually updated Kansas City Cardiomyopathy Questionnaire score was independently associated with higher risk of incident HF hospitalization in multivariable-adjusted models (odds ratio, 3.30 [1.66-6.52]; P=0.001 for Q1 compared with Q4). Symptoms characteristic of HF are common in patients with chronic kidney disease and are associated with higher short-term risk for new hospitalization for HF, independent of level of kidney function, and other known HF risk factors. © 2015 American Heart Association, Inc.

  2. Study of characteristic X-ray source and its applications

    International Nuclear Information System (INIS)

    Li Fuquan

    1994-11-01

    The law of characteristic X-rays emitted by target element under the radiation of isotope source in a range of low energy is discussed. Both the way of improving the rate of γ-X conversion and the method to eliminate the influence of scatter rays are introduced. The influence of the variation of isotopes source, targets and the relative position of source-target to the output of X-rays is also discussed and then the conditions of improving signal-to-noise radio is presented. The X-ray source based on these results can produce different energy X-rays, and so can be broadly used on nuclear instruments and other fields as a low energy source. The thickness gauge, as one of the applications, has succeeded in thickness measuring of the different materials in large range, and it presents a new application field for characteristic X-ray source. (11 figs., 10 tabs.)

  3. Molecular line study of massive star-forming regions from the Red MSX Source survey

    Science.gov (United States)

    Yu, Naiping; Wang, Jun-Jie

    2014-05-01

    In this paper, we have selected a sample of massive star-forming regions from the Red MSX Source survey, in order to study star formation activities (mainly outflow and inflow signatures). We have focused on three molecular lines from the Millimeter Astronomy Legacy Team Survey at 90 GHz: HCO+(1-0), H13CO+(1-0) and SiO(2-1). According to previous observations, our sources can be divided into two groups: nine massive young stellar object candidates (radio-quiet) and 10 H II regions (which have spherical or unresolved radio emissions). Outflow activities have been found in 11 sources, while only three show inflow signatures in all. The high outflow detection rate means that outflows are common in massive star-forming regions. The inflow detection rate was relatively low. We suggest that this was because of the beam dilution of the telescope. All three inflow candidates have outflow(s). The outward radiation and thermal pressure from the central massive star(s) do not seem to be strong enough to halt accretion in G345.0034-00.2240. Our simple model of G318.9480-00.1969 shows that it has an infall velocity of about 1.8 km s-1. The spectral energy distribution analysis agrees our sources are massive and intermediate-massive star formation regions.

  4. A Business Case Study of Open Source Software

    Science.gov (United States)

    2001-07-01

    include cost or price, availability or multiple distribution sources, and popularity or brand /reputation. While both the commercial and government...availability, quality, security, management, scalability, brand /reputation, and service and support. 1 2 3 4 5 Pr ice Re lia bil ity Pe rfo rm an ce Av ail...source community. Open source, and Linux in particular, is often regarded as the heroic underdog . Linux has been touted as a “Windows killer.”44 Over

  5. Evaluation of an Information Source Illustrated by a Case Study

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2011-01-01

    It is argued that to evaluate an information source (e.g., a Wikipedia article), it is necessary to relate the content of that source to an interpretation of the state of knowledge at the research front (which is typically developing dynamically). In the research literature, there is a controversy...... about the effect of screening programs for breast cancer. This controversy is used to compare the value of Wikipedia with Encyclopedia Britannica and two Danish encyclopedias as information sources. It is argued that this method of examining information sources is preferable to other methods which have...

  6. Barrow Black Carbon Source and Impact Study Final Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Barrett, Tate

    2014-07-01

    The goal of the Barrow Black Carbon Source and Impact campaign was to characterize the concentration and isotopic composition of carbonaceous atmospheric particulate matter (PM) at the Atmospheric Radiation Measurement (ARM) Climate Research Facility site in Barrow, Alaska. The carbonaceous component was characterized by measuring the organic and black carbon (OC and BC) components of the total PM. To facilitate complete characterization of the PM, filter-based collections were used, including a medium volume PM2.5 sampler and a high volume PM10 sampler. Thirty-eight fine PM fractions (PM2.5) and 49 coarse (PM10) PM fractions were collected at weekly and bi-monthly intervals. The PM2.5 sampler operated with minimal maintenance during the 12 month campaign. The PM10 sampler used for the Barrow Black Carbon Source and Impact (BBCSI) study used standard Tisch “hi-vol” motors that have a known lifetime of approximately 1 month under constant use; this necessitated monthly maintenance, and it is suggested that, for future deployment in the Arctic, the motors be upgraded to industrial blowers. The BBCSI sampling campaign successfully collected and archived 87 ambient atmospheric PM samples from Barrow, Alaska, from July 2012 to June 2013. Preliminary analysis of the OC and BC concentrations has been completed. This campaign confirmed known trends of high BC lasting from the winter through to spring haze periods and low BC concentrations in the summer. However, the annual OC concentrations had a very different seasonal pattern with the highest concentrations during the summer, lowest concentrations during the fall, and increased concentrations during the winter and spring (Figure 1).

  7. Light ion source studies with a magnetically insulated extraction diode

    International Nuclear Information System (INIS)

    Struckman, C.K.

    1992-01-01

    Light ion sources are currently being studied to assess their ability to drive an inertial confinement fusion reactor. The author has produced a high purity, 1MV, 300A/cm 2 lithium beam using a 200cm 2 extraction geometry, magnetically insulated ion diode. The lithium source was an AC glow discharge cleaned, LiF/Al film active anode. The active anode plasma was formed after 50KA of current was shunted through the anode film for 20ns. The stoichiometry of the resulting ion beam was 65% Li + , 20% Al +2 , and 15% H + . Without the glow discharge cleaning, the ion beam was over 55% hydrogen and only 20% Li + . At the time of the diode's design, extraction diodes were producing poor ion beams: their current efficiency was only 60-70%, and their extracted ion current was radially nonuniform. This diode was the first high efficiency extraction diode, and produced over 200KA of ions with 80-90% ion current efficiency. In addition, by varying the tilt of the applied magnetic field, it was possible to show that the ion current density could be made independent of radius. Since the author was unable to make a Li + beam with a passive anode, he installed an active anode that used an external current to vaporize a thin metal film on the anode surface. Poor beam purity was the most serious problem with active anodes. In order to remove impurities, especially the hydrogen contamination, the author cleaned the anodes with a glow discharge. Al film anodes were cleaned with a 110mA, 33W DC glow discharge, and the LiF/Al film anodes were cleaned with an equivalent AC discharge. The results obtained and a model for the mechanism behind the cleaning process are throughly discussed

  8. 5 MW pulsed spallation neutron source, Preconceptual design study

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    This report describes a self-consistent base line design for a 5 MW Pulsed Spallation Neutron Source (PSNS). It is intended to establish feasibility of design and as a basis for further expanded and detailed studies. It may also serve as a basis for establishing project cost (30% accuracy) in order to intercompare competing designs for a PSNS not only on the basis of technical feasibility and technical merit but also on the basis of projected total cost. The accelerator design considered here is based on the objective of a pulsed neutron source obtained by means of a pulsed proton beam with average beam power of 5 MW, in {approx} 1 {mu}sec pulses, operating at a repetition rate of 60 Hz. Two target stations are incorporated in the basic facility: one for operation at 10 Hz for long-wavelength instruments, and one operating at 50 Hz for instruments utilizing thermal neutrons. The design approach for the proton accelerator is to use a low energy linear accelerator (at 0.6 GeV), operating at 60 Hz, in tandem with two fast cycling booster synchrotrons (at 3.6 GeV), operating at 30 Hz. It is assumed here that considerations of cost and overall system reliability may favor the present design approach over the alternative approach pursued elsewhere, whereby use is made of a high energy linear accelerator in conjunction with a dc accumulation ring. With the knowledge that this alternative design is under active development, it was deliberately decided to favor here the low energy linac-fast cycling booster approach. Clearly, the present design, as developed here, must be carried to the full conceptual design stage in order to facilitate a meaningful technology and cost comparison with alternative designs.

  9. 5 MW pulsed spallation neutron source, Preconceptual design study

    International Nuclear Information System (INIS)

    1994-06-01

    This report describes a self-consistent base line design for a 5 MW Pulsed Spallation Neutron Source (PSNS). It is intended to establish feasibility of design and as a basis for further expanded and detailed studies. It may also serve as a basis for establishing project cost (30% accuracy) in order to intercompare competing designs for a PSNS not only on the basis of technical feasibility and technical merit but also on the basis of projected total cost. The accelerator design considered here is based on the objective of a pulsed neutron source obtained by means of a pulsed proton beam with average beam power of 5 MW, in ∼ 1 μsec pulses, operating at a repetition rate of 60 Hz. Two target stations are incorporated in the basic facility: one for operation at 10 Hz for long-wavelength instruments, and one operating at 50 Hz for instruments utilizing thermal neutrons. The design approach for the proton accelerator is to use a low energy linear accelerator (at 0.6 GeV), operating at 60 Hz, in tandem with two fast cycling booster synchrotrons (at 3.6 GeV), operating at 30 Hz. It is assumed here that considerations of cost and overall system reliability may favor the present design approach over the alternative approach pursued elsewhere, whereby use is made of a high energy linear accelerator in conjunction with a dc accumulation ring. With the knowledge that this alternative design is under active development, it was deliberately decided to favor here the low energy linac-fast cycling booster approach. Clearly, the present design, as developed here, must be carried to the full conceptual design stage in order to facilitate a meaningful technology and cost comparison with alternative designs

  10. RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study

    International Nuclear Information System (INIS)

    Weber, Damien C; Miralbell, Raymond; Wang, Hui; Cozzi, Luca; Dipasquale, Giovanna; Khan, Haleem G; Ratib, Osman; Rouzaud, Michel; Vees, Hansjoerg; Zaidi, Habib

    2009-01-01

    A study was performed comparing volumetric modulated arcs (RA) and intensity modulation (with photons, IMRT, or protons, IMPT) radiation therapy (RT) for patients with recurrent prostate cancer after RT. Plans for RA, IMRT and IMPT were optimized for 7 patients. Prescribed dose was 56 Gy in 14 fractions. The recurrent gross tumor volume (GTV) was defined on 18 F-fluorocholine PET/CT scans. Plans aimed to cover at least 95% of the planning target volume with a dose > 50.4 Gy. A maximum dose (D Max ) of 61.6 Gy was allowed to 5% of the GTV. For the urethra, D Max was constrained to 37 Gy. Rectal D Median was < 17 Gy. Results were analyzed using Dose-Volume Histogram and conformity index (CI 90 ) parameters. Tumor coverage (GTV and PTV) was improved with RA (V 95% 92.6 ± 7.9 and 83.7 ± 3.3%), when compared to IMRT (V 95% 88.6 ± 10.8 and 77.2 ± 2.2%). The corresponding values for IMPT were intermediate for the GTV (V 95% 88.9 ± 10.5%) and better for the PTV (V 95% 85.6 ± 5.0%). The percentages of rectal and urethral volumes receiving intermediate doses (35 Gy) were significantly decreased with RA (5.1 ± 3.0 and 38.0 ± 25.3%) and IMPT (3.9 ± 2.7 and 25.1 ± 21.1%), when compared to IMRT (9.8 ± 5.3 and 60.7 ± 41.7%). CI 90 was 1.3 ± 0.1 for photons and 1.6 ± 0.2 for protons. Integral Dose was 1.1 ± 0.5 Gy*cm 3 *10 5 for IMPT and about a factor three higher for all photon's techniques. RA and IMPT showed improvements in conformal avoidance relative to fixed beam IMRT for 7 patients with recurrent prostate cancer. IMPT showed further sparing of organs at risk

  11. Phase 2 study of tabalumab, a human anti-B-cell activating factor antibody, with bortezomib and dexamethasone in patients with previously treated multiple myeloma.

    Science.gov (United States)

    Raje, Noopur S; Moreau, Philippe; Terpos, Evangelos; Benboubker, Lotfi; Grząśko, Norbert; Holstein, Sarah A; Oriol, Albert; Huang, Shang-Yi; Beksac, Meral; Kuliczkowski, Kazimierz; Tai, Datchen F; Wooldridge, James E; Conti, Ilaria; Kaiser, Christopher J; Nguyen, Tuan S; Cronier, Damien M; Palumbo, Antonio

    2017-03-01

    In this double-blind, Phase 2 study, 220 patients with relapsed/refractory multiple myeloma were randomly assigned 1:1:1 to receive placebo (N = 72), tabalumab 100 mg (N = 74), or tabalumab 300 mg (N = 74), each in combination with dexamethasone 20 mg and subcutaneous bortezomib 1·3 mg/m 2 on a 21-day cycle. No significant intergroup differences were observed among primary (median progression-free survival [mPFS]) or secondary efficacy outcomes. The mPFS was 6·6, 7·5 and 7·6 months for the tabalumab 100, 300 mg and placebo groups, respectively (tabalumab 100 mg vs. placebo Hazard ratio (HR) [95% confidence interval (CI)] = 1·13 [0·80-1·59], P = 0·480; tabalumab 300 mg vs. placebo HR [95% CI] = 1·03 [0·72-1·45], P = 0·884). The most commonly-reported treatment-emergent adverse events were thrombocytopenia (37%), fatigue (37%), diarrhoea (35%) and constipation (32%). Across treatments, patients with low baseline BAFF (also termed TNFSF13B) expression (n = 162) had significantly longer mPFS than those with high BAFF expression (n = 55), using the 75th percentile cut-off point (mPFS [95% CI] = 8·3 [7·0-9·3] months vs. 5·8 [3·7-6·6] months; HR [95% CI] = 1·59 [1·11-2·29], P = 0·015). Although generally well tolerated, PFS was not improved during treatment with tabalumab compared to placebo. A higher dose of 300 mg tabalumab did not improve efficacy compared to the 100 mg dose. Nonetheless, BAFF appears to have some prognostic value in patients with multiple myeloma. © 2016 John Wiley & Sons Ltd.

  12. Previously unknown species of Aspergillus.

    Science.gov (United States)

    Gautier, M; Normand, A-C; Ranque, S

    2016-08-01

    The use of multi-locus DNA sequence analysis has led to the description of previously unknown 'cryptic' Aspergillus species, whereas classical morphology-based identification of Aspergillus remains limited to the section or species-complex level. The current literature highlights two main features concerning these 'cryptic' Aspergillus species. First, the prevalence of such species in clinical samples is relatively high compared with emergent filamentous fungal taxa such as Mucorales, Scedosporium or Fusarium. Second, it is clearly important to identify these species in the clinical laboratory because of the high frequency of antifungal drug-resistant isolates of such Aspergillus species. Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) has recently been shown to enable the identification of filamentous fungi with an accuracy similar to that of DNA sequence-based methods. As MALDI-TOF MS is well suited to the routine clinical laboratory workflow, it facilitates the identification of these 'cryptic' Aspergillus species at the routine mycology bench. The rapid establishment of enhanced filamentous fungi identification facilities will lead to a better understanding of the epidemiology and clinical importance of these emerging Aspergillus species. Based on routine MALDI-TOF MS-based identification results, we provide original insights into the key interpretation issues of a positive Aspergillus culture from a clinical sample. Which ubiquitous species that are frequently isolated from air samples are rarely involved in human invasive disease? Can both the species and the type of biological sample indicate Aspergillus carriage, colonization or infection in a patient? Highly accurate routine filamentous fungi identification is central to enhance the understanding of these previously unknown Aspergillus species, with a vital impact on further improved patient care. Copyright © 2016 European Society of Clinical Microbiology and

  13. Study theorizes use of geothermal sources for energy in refineries

    NARCIS (Netherlands)

    Golombok, M.; Beintema, K.

    2008-01-01

    Geothermal sources for direct heating can theoretically serve as an alternative source of high-temperature heat in processing plants. Cutting CO2 emissions from a refinery requires reducing the amount of fuel burned. Heat obtained from geothermal energy is more efficiently used for directly powering

  14. A Study of Porphyrins in Petroleum Source Rocks

    Energy Technology Data Exchange (ETDEWEB)

    Huseby, Berit

    1997-12-31

    This thesis discusses several aspects of porphyrin geochemistry. Degradation experiments have been performed on the Messel oil shale (Eocene, Germany) to obtain information on porphyrins bound or incorporated into macromolecular structures. Thermal heating of the preextracted kerogen by hydrous pyrolysis was used to study the release of porphyrins and their temperature dependent changes during simulated diagenesis and catagenesis. Selective chemical degradation experiments were performed on the preextracted sediment to get more detailed information about porphyrins that are specifically bound to the macromolecular structures via ester bonds. From the heating experiments, in a separate study, the porphyrin nitrogen content in the generated bitumens was compared to the bulk of organic nitrogen compounds in the fraction. The bulk nitrogen contents in the generated bitumens, the water phase and the residual organic matter was recorded to establish the distribution of nitrogen between the kerogen and product phases. Porphyrins as biomarkers were examined in naturally matured Kimmeridge clay source rocks (Upper Jurassic, Norway), and the use of porphyrins as general indicators of maturity was evaluated. Underlying maturity trends in the biomarker data was investigated by Partial Least Squares analysis. Porphyrin as indicators of depositional conditions was also addressed, where the correlations between the (amounts) abundance of nickel and vanadyl porphyrins were mapped together with other descriptors that are assumed to be indicative of redox depositional conditions. 252 refs., 28 figs., 4 tabs.

  15. Radiotracer and Sealed Source Applications in Sediment Transport Studies

    International Nuclear Information System (INIS)

    2014-01-01

    The investigation of sediment transport in seas and rivers is crucial for civil engineering and littoral protection and management. Coastlines and seabeds are dynamic regions, with sediments undergoing periods of erosion, transport, sedimentation and consolidation. The main causes for erosion in beaches include storms and human actions such as the construction of seawalls, jetties and the dredging of stream mouths. Each of these human actions disrupts the natural flow of sand. Current policies and practices are accelerating the beach erosion process. However, there are viable options available to mitigate this damage and to provide for sustainable coastlines. Radioactive methods can help in investigating sediment dynamics, providing important parameters for better designing, maintaining and optimizing civil engineering structures. Radioisotopes as tracers and sealed sources have been useful and often irreplaceable tools for sediment transport studies. The training course material is based on lecture notes and practical works delivered by many experts in IAEA supported activities. Lectures and case studies were reviewed by a number of specialists in this field

  16. Sources of International Courts' Legitimacy: A comparative study

    DEFF Research Database (Denmark)

    Godzimirska, Zuzanna; Creamer, Cosette

    Despite ample scholarship on the legitimacy of international legal institutions, existing studies on international courts (ICs) tend to adopt normative or deductive approaches to specify their legitimacy and assess its effects. Very few adopt empirical or inductive approaches and examine the reas......Despite ample scholarship on the legitimacy of international legal institutions, existing studies on international courts (ICs) tend to adopt normative or deductive approaches to specify their legitimacy and assess its effects. Very few adopt empirical or inductive approaches and examine...... of supply-side factors— the features, roles and practices of a court—in assessing its legitimacy, we argue that demand-side factors—namely the characteristics of the evaluating state—also largely determine the sources of an IC’s legitimacy. To support and illustrate this argument, we examine statements...... of members on the operation of three ICs with different institutional designs and roles: the International Court of Justice, the International Criminal Court, and the Appellate Body of the World Trade Organization. We employ supervised learning methods of text classification to identify statements...

  17. A Study of Porphyrins in Petroleum Source Rocks

    Energy Technology Data Exchange (ETDEWEB)

    Huseby, Berit

    1996-12-31

    This thesis discusses several aspects of porphyrin geochemistry. Degradation experiments have been performed on the Messel oil shale (Eocene, Germany) to obtain information on porphyrins bound or incorporated into macromolecular structures. Thermal heating of the preextracted kerogen by hydrous pyrolysis was used to study the release of porphyrins and their temperature dependent changes during simulated diagenesis and catagenesis. Selective chemical degradation experiments were performed on the preextracted sediment to get more detailed information about porphyrins that are specifically bound to the macromolecular structures via ester bonds. From the heating experiments, in a separate study, the porphyrin nitrogen content in the generated bitumens was compared to the bulk of organic nitrogen compounds in the fraction. The bulk nitrogen contents in the generated bitumens, the water phase and the residual organic matter was recorded to establish the distribution of nitrogen between the kerogen and product phases. Porphyrins as biomarkers were examined in naturally matured Kimmeridge clay source rocks (Upper Jurassic, Norway), and the use of porphyrins as general indicators of maturity was evaluated. Underlying maturity trends in the biomarker data was investigated by Partial Least Squares analysis. Porphyrin as indicators of depositional conditions was also addressed, where the correlations between the (amounts) abundance of nickel and vanadyl porphyrins were mapped together with other descriptors that are assumed to be indicative of redox depositional conditions. 252 refs., 28 figs., 4 tabs.

  18. Intrabeam scattering studies at the Swiss light source

    CERN Document Server

    Antoniou, F; Aiba, M; Boege, M; Milas, N; Streun, A; Demma, T

    2012-01-01

    The target parameters of modern ultra-low emittance rings are entering into a regime where Intra-beam Scattering (IBS) becomes important and, in the case of linear collider damping rings, even a limitation for the delivered emittances. The Swiss Light Source (SLS) storage ring, as it has achieved a vertical geometrical emittance of around 1 pm at 2.4 GeV [1], and it has the ability to run at even lower energies, and the availability of emittance monitoring diagnostics, is an ideal testbed for IBS studies. Simulations using the classical IBS theories and tracking codes are undertaken in order to explore the possibilities and limitations for IBS measurements at the SLS. In this respect, comparison between the theories and codes is first discussed. The dependence of the output emittances, taking into account the effect of IBS, with respect to energy, bunch charge and zero current vertical and longitudinal emittance is also studied, in order to define the regimes where the IBS effect can be significant. First mea...

  19. Study and characterization of a phosphorous ion source and development of a emittancemeter suited to multi-beam ion sources

    International Nuclear Information System (INIS)

    Hoang Gia Tuong.

    1982-12-01

    The ionization process which is used is the electronic bombardment. Phosphorus choice for the source experimentation is motivated by its principal destination: ionic implantation. Heavy ion applications are also quoted. Operating conditions allowing good results to be obtained are determined after a study of different parameters such as the electron current, the neutron pressure and the extraction voltage: the ion current obtained is of the order of mA. The source emittance, representing the quality of the ionic beam, is measured by a method suited to multibeam sources [fr

  20. Study of hot electrons in a ECR ion source

    International Nuclear Information System (INIS)

    Barue, C.

    1992-12-01

    The perfecting of diagnosis connected with hot electrons of plasma, and then the behaviour of measured parameters of plasma according to parameters of source working are the purpose of this thesis. The experimental results obtained give new information on hot electrons of an ECR ion source. This thesis is divided in 4 parts: the first part presents an ECR source and the experimental configuration (ECRIS physics, minimafios GHz, diagnosis used); the second part, the diagnosis (computer code of cyclotron emission and calibration); the third part gives experimental results in continuous regime (emission cyclotron diagnosis, bremsstrahlung); the fourth part, experimental results in pulsed regime (emission cyclotron diagnosis, diamagnetism) calibration)

  1. Study on road surface source pollution controlled by permeable pavement

    Science.gov (United States)

    Zheng, Chaocheng

    2018-06-01

    The increase of impermeable pavement in urban construction not only increases the runoff of the pavement, but also produces a large number of Non-Point Source Pollution. In the process of controlling road surface runoff by permeable pavement, a large number of particulate matter will be withheld when rainwater is being infiltrated, so as to control the source pollution at the source. In this experiment, we determined the effect of permeable road surface to remove heavy pollutants in the laboratory and discussed the related factors that affect the non-point pollution of permeable pavement, so as to provide a theoretical basis for the application of permeable pavement.

  2. Barrow Black Carbon Source and Impact Study Final Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Barrett, Tate [Baylor Univ., Waco, TX (United States)

    2014-07-01

    The goal of the Barrow Black Carbon Source and Impact (BBCSI) Study was to characterize the concentration and isotopic composition of carbonaceous atmospheric particulate matter (PM) at the Atmospheric Radiation Measurement site in Barrow, AK. The carbonaceous component was characterized via measurement of the organic and black carbon (OC and BC) components of the total PM. To facilitate complete characterization of the particulate matter, filter-based collections were used, including a medium volume PM2.5 sampler and a high volume PM10 sampler. Thirty-eight fine (PM2.5) and 49 coarse (PM10) particulate matter fractions were collected at weekly and bi-monthly intervals. The PM2.5 sampler operated with minimal maintenance during the 12 month campaign. The PM10 sampler used for the BBCSI used standard Tisch hi-vol motors which have a known lifetime of ~1 month under constant use; this necessitated monthly maintenance and it is suggested that the motors be upgraded to industrial blowers for future deployment in the Arctic. The BBCSI sampling campaign successfully collected and archived 87 ambient atmospheric particulate matter samples from Barrow, AK from July 2012 to June 2013. Preliminary analysis of the organic and black carbon concentrations has been completed. This campaign confirmed known trends of high BC lasting from the winter through to spring haze periods and low BC concentrations in the summer.

  3. Studies of IRAS sources at high galactic latitudes

    International Nuclear Information System (INIS)

    Rowan-Robinson, M.; Helou, G.; Walker, D.

    1987-01-01

    A detailed study has been carried out of a complete sample of IRAS 25-, 60- and 100-μm sources identified with galaxies brighter than 14.5 mag at b > 60 0 . Redshifts are available for virtually all these galaxies. The 60- and 100-μm luminosities are well correlated with the corrected absolute magnitude Msub(B), the 25-μm luminosity less well so. There is a clear correlation of the ratio of far-infrared luminosity to optical luminosity, Lsub(FIR)/Lsub(B), with 100 μm/60 μm colour, in the sense that the more luminous infrared galaxies are warmer. This behaviour can be modelled as a mixture of a normal 'disc' component and a starburst component. There is no significant difference in the distribution of Lsub(FIR)/Lsub(B) versus 100 μm/60 μm colour for edge-on and face-on spirals, showing that the adopted internal extinction correction is a good approximation. (author)

  4. A 12 GHz RF Power Source for the CLIC Study

    Energy Technology Data Exchange (ETDEWEB)

    Schirm, Karl; /CERN; Curt, Stephane; /CERN; Dobert, Steffen; /CERN; McMonagle, Gerard; /CERN; Rossat, Ghislain; /CERN; Syratchev, Igor; /CERN; Timeo, Luca; /CERN; Haase, Andrew /SLAC; Jensen, Aaron; /SLAC; Jongewaard, Erik; /SLAC; Nantista, Christopher; /SLAC; Sprehn, Daryl; /SLAC; Vlieks, Arnold; /SLAC; Hamdi, Abdallah; /Saclay; Peauger, Franck; /Saclay; Kuzikov, Sergey; /Nizhnii Novgorod, IAP; Vikharev, Alexandr; /Nizhnii Novgorod, IAP

    2012-07-03

    The CLIC RF frequency has been changed in 2008 from the initial 30 GHz to the European X-band 11.9942 GHz permitting beam independent power production using klystrons for CLIC accelerating structure testing. A design and fabrication contract for five klystrons at that frequency has been signed by different parties with SLAC. France (IRFU, CEA Saclay) is contributing a solid state modulator purchased in industry and specific 12 GHz RF network components to the CLIC study. RF pulses over 120 MW peak at 230 ns length will be obtained by using a novel SLED-I type pulse compression scheme designed and fabricated by IAP, Nizhny Novgorod, Russia. The X-band power test stand is being installed in the CLIC Test Facility CTF3 for independent structure and component testing in a bunker, but allowing, in a later stage, for powering RF components in the CTF3 beam lines. The design of the facility, results from commissioning of the RF power source and the expected performance of the Test Facility are reported.

  5. A 12 GHZ RF Power source for the CLIC study

    CERN Document Server

    Peauger, F; Curt, S; Doebert, S; McMonagle, G; Rossat, G; Schirm, KM; Syratchev, I; Timeo, L; Kuzikhov, S; Vikharev, AA; Haase, A; Sprehn, D; Jensen, A; Jongewaard, EN; Nantista, CD; Vlieks, A

    2010-01-01

    The CLIC RF frequency has been changed in 2008 from the initial 30 GHz to the European X-band 11.9942 GHz permitting beam independent power production using klystrons for CLIC accelerating structure testing. A design and fabrication contract for five klystrons at that frequency has been signed by different parties with SLAC. France (IRFU, CEA Saclay) is contributing a solid state modulator purchased in industry and specific 12 GHz RF network components to the CLIC study. RF pulses over 120 MW peak at 230 ns length will be obtained by using a novel SLED-I type pulse compression scheme designed and fabricated by IAP, Nizhny Novgorod, Russia. The X-band power test stand is being installed in the CLIC Test Facility CTF3 for independent structure and component testing in a bunker, but allowing, in a later stage, for powering RF components in the CTF3 beam lines. The design of the facility, results from commissioning of the RF power source and the expected performance of the Test Facility are reported.

  6. Source separation of household waste: A case study in China

    International Nuclear Information System (INIS)

    Zhuang Ying; Wu Songwei; Wang Yunlong; Wu Weixiang; Chen Yingxu

    2008-01-01

    A pilot program concerning source separation of household waste was launched in Hangzhou, capital city of Zhejiang province, China. Detailed investigations on the composition and properties of household waste in the experimental communities revealed that high water content and high percentage of food waste are the main limiting factors in the recovery of recyclables, especially paper from household waste, and the main contributors to the high cost and low efficiency of waste disposal. On the basis of the investigation, a novel source separation method, according to which household waste was classified as food waste, dry waste and harmful waste, was proposed and performed in four selected communities. In addition, a corresponding household waste management system that involves all stakeholders, a recovery system and a mechanical dehydration system for food waste were constituted to promote source separation activity. Performances and the questionnaire survey results showed that the active support and investment of a real estate company and a community residential committee play important roles in enhancing public participation and awareness of the importance of waste source separation. In comparison with the conventional mixed collection and transportation system of household waste, the established source separation and management system is cost-effective. It could be extended to the entire city and used by other cities in China as a source of reference

  7. Comparative study of wild edible mushrooms as sources of antioxidants.

    Science.gov (United States)

    Witkowska, Anna M; Zujko, Małgorzata E; Mirończuk-Chodakowska, Iwona

    2011-01-01

    The purpose of the study was to explore sixteen of the most popular edible species of wild-growing mushrooms as potential sources of antioxidants. Among the mushrooms tested, the highest total polyphenol contents, exceeding 100 mg/100 g fresh mass, were found in five mushrooms: Boletus chrysenteron, B. edulis, Leccinum scabrum, L. aurantiacum, and Macrolepiota procera. Antioxidant activity was measured with the FRAP, TEAC, DPPH scavenging ability and ferrous ions chelating ability assays. Results of the study show that wild mushrooms vary according to their antioxidant properties. The highest FRAP potentials, exceeding 1 mmol/100 g, were found in five species ofBoletales: Boletus edulis, B. chrysenteron, Leccinum scabrum, L. aurantiacum, and Suillus grevillei. TEAC values were from 1.07 to 4.01 mmol/100 g fresh mass. High TEAC values (>2.3 mmol/100 g) were found in Leccinum scabrum, L. aurantiacum, Macrolepiota procera, Boletus chrysenteron, and B. edulis. The DPPH radical scavenging effectiveness of mushroom extracts, expressed as EC50 values, was in range 2.91-13.86 mg/mL. Scavenging ability was the highest for B. edulis and B. chrysenteron. The metal chelating ability of mushroom extracts expressed as ECso values of chelating ability on ferrous ions were from 8.02 mg/mL in Cantharellus cibarius to 12.10 mg/mL in Suillus luteus. Among the mushrooms tested, Boletus chrysenteron and B. edulis were characterized by high scores of polyphenol contents and antioxidant activity in the FRAP, TEAC, and DPPH assays. These results place these culinary species of wild-growing mushrooms among products with considerable antioxidant potential.

  8. Dietary sources of sugars in adolescents' diet: the HELENA study.

    Science.gov (United States)

    Mesana, M I; Hilbig, A; Androutsos, O; Cuenca-García, M; Dallongeville, J; Huybrechts, I; De Henauw, S; Widhalm, K; Kafatos, A; Nova, E; Marcos, A; González-Gross, M; Molnar, D; Gottrand, F; Moreno, L A

    2018-03-01

    To report dietary sugars consumption and their different types and food sources, in European adolescents. Food consumption data of selected groups were obtained from 1630 adolescents (45.6% males, 12.5-17.5 years) from the HELENA study using two nonconsecutive 24-h recalls. Energy intake, total sugars and free sugars were assessed using the HELENA-DIAT software. Multiple regression analyses were performed adjusting for relevant confounders. Total sugars intake (137.5 g/day) represented 23.6% and free sugars (110.1 g/day), 19% of energy intake. Girls had significantly lower intakes of energy, carbohydrates, total sugars and free sugars. 94% of adolescents had a consumption of free sugars above 10% of total energy intake. The main food contributor to free sugars was 'carbonated, soft and isotonic drinks,' followed by 'non-chocolate confectionary' and 'sugar, honey, jam and syrup.' Older boys and girls had significantly higher intakes of free sugars from 'cakes, pies and biscuits.' Free sugars intake was negatively associated with low socioeconomic status for 'non-chocolate confectionary' and 'sugar, honey and jam' groups; with low maternal educational level for carbonated and 'soft drinks,' 'sugar, honey and jam,' 'cakes and pies' and 'breakfast cereals' groups; and with high paternal educational level for 'carbonated and soft drinks' and 'chocolates' group. The majority (94%) of studied adolescents consumed free sugars above 10% of daily energy intake. Our data indicate a broad variety in foods providing free sugars. Continued efforts are required at different levels to reduce the intake of free sugars, especially in families with a low educational level.

  9. Preoperative screening: value of previous tests.

    Science.gov (United States)

    Macpherson, D S; Snow, R; Lofgren, R P

    1990-12-15

    To determine the frequency of tests done in the year before elective surgery that might substitute for preoperative screening tests and to determine the frequency of test results that change from a normal value to a value likely to alter perioperative management. Retrospective cohort analysis of computerized laboratory data (complete blood count, sodium, potassium, and creatinine levels, prothrombin time, and partial thromboplastin time). Urban tertiary care Veterans Affairs Hospital. Consecutive sample of 1109 patients who had elective surgery in 1988. At admission, 7549 preoperative tests were done, 47% of which duplicated tests performed in the previous year. Of 3096 previous results that were normal as defined by hospital reference range and done closest to the time of but before admission (median interval, 2 months), 13 (0.4%; 95% CI, 0.2% to 0.7%), repeat values were outside a range considered acceptable for surgery. Most of the abnormalities were predictable from the patient's history, and most were not noted in the medical record. Of 461 previous tests that were abnormal, 78 (17%; CI, 13% to 20%) repeat values at admission were outside a range considered acceptable for surgery (P less than 0.001, frequency of clinically important abnormalities of patients with normal previous results with those with abnormal previous results). Physicians evaluating patients preoperatively could safely substitute the previous test results analyzed in this study for preoperative screening tests if the previous tests are normal and no obvious indication for retesting is present.

  10. CURRENT STUDY ON THE FUNDING SOURCES COVERAGE OF CURRENT ASSETS TO COMPANIES LISTED ON THE BUCHAREST STOCK EXCHANGE

    Directory of Open Access Journals (Sweden)

    Teodor HADA

    2014-06-01

    Full Text Available This paper presents issues about the coverage with financing sources of current assets for 64 companies listed on the Bucharest Stock Exchange. The aim of the study is to see how to calculate indicators specific to current assets and the general framework offered as whole analysis of the financing sources of current assets. The introduction of the paper presents the objective, the research methodology and the novelties brought by this study. Further on, this study shows the various views of the authors about the concept of "current assets", financing sources of current assets, the calculation of net working capital, setting the limits of the normal working capital and determining the speed of rotation. After that was done, based on the theory, a case study was performed, for companies covered in this study. Conclusions focused on determining the final data about what was detailed in the previous paragraphs.

  11. 2007 California Aerosol Study: Evaluation of δ15N as a Tracer Of NOx Sources and Chemsitry

    Science.gov (United States)

    Katzman, T. L.

    2017-12-01

    Although stable isotopes of N are commonly used as a source tracer, how this tracer is applied is a point of contention. The "source" hypothesis argues that the δ15N value of NO3- reflects the δ15N value of NOx source inputs into the environment, and any observed variation is solely the result of differences in source contributions. Conversely, the "chemistry" hypothesis argues that N isotopes are influenced by chemical reactions, atmospheric or biologic processing, and post-depositional effects. Previous studies often apply the source hypothesis, writing off the chemistry hypothesis as "minor," but others have noted the impact chemistry should has on δ15N values. Given the known complications, this work seeks to assess the use of stable isotopes as tracers, specifically, the assumption that the δ15N value is a tracer of source alone without significant influence from chemical reactions. If the "source" hypothesis is correct, source emission data, known source δ15N values, and isotope mass balance should be able to approximate measured δ15NNO3 values and determine the δ15N value associated with wildfire derived NOx, which is currently unknown. Significant deviations from observed values would support the significance of equilibrium and kinetic isotope effects associated with chemical reactions and processing in the atmosphere. Aerosols collected in during 2007, emission data, and isotopic analysis were utilized to determine the utility of δ15N as tracer of NOx sources. San Diego, California is a coastal urban area influenced by sea salt aerosols, anthropogenic combustion emissions, and seasonal wildfires. Wildfires also have a significant influence on local atmospheric chemistry and 2007 was notable for being one of the worst fire seasons in the San Diego region on record. Isotopic analysis of collected NO3- has suggested that source δ15N values are likely not conserved as NOx is oxidized into NO3-. Given known source contributions and known δ15N values

  12. Nest materials as a source of genetic data for avian ecological studies

    Science.gov (United States)

    Pearce, J.M.; Fields, R.L.; Scribner, K.T.

    1997-01-01

    We examined the utility of feathers and egg shell membranes, deposited in the nests of Spectacled Eiders (Somateria fischeri), as a source of DNA for genetic studies at both the population and individual level. The potential for feather DNA contamination as a result of female behavioral interactions (e.g. nest parasitism), reuse of nest sites from previous years, or other unknown occurrences was acknowledged and specifically tested. DNA was successfully extracted from both feathers and egg shell membranes and waterfowl microsatellite loci were used to construct individual genotypes. We found no difference in the genotypes obtained from nest feathers or blood of the incubating female. Detection of nest feather contamination was possible with as little as one feather when samples from multiple females were intentionally mixed. Triplicate DNA extractions from 33 nests provided a means of detecting contamination in 3 nests. Egg membranes proved a viable source of offspring DNA and can contribute valuable data to investigations of parentage when assayed jointly with maternal feather DNA. Nest materials provide an efficient, non-invasive method of genetic sampling that can be readily incorporated into field research. However, the natural history traits and mating strategies of a species must be considered during sample collection to identify the possible sources of nest materials (e.g., paternal, maternal, parasite, etc.). Specific experiments should also be designed to test sampling assumptions.

  13. Pinon Pine Tree Study, Los Alamos National Laboratory: Source document

    International Nuclear Information System (INIS)

    Gonzales, G.J.; Fresquez, P.R.; Mullen, M.A.; Naranjo, L. Jr.

    2000-01-01

    One of the dominant tree species growing within and around Los Alamos National Laboratory (LANL), Los Alamos, NM, lands is the pinon pine (Pinus edulis) tree. Pinon pine is used for firewood, fence posts, and building materials and is a source of nuts for food--the seeds are consumed by a wide variety of animals and are also gathered by people in the area and eaten raw or roasted. This study investigated the (1) concentration of 3 H, 137 Cs, 90 Sr, tot U, 238 Pu, 239,240 Pu, and 241 Am in soils (0- to 12-in. [31 cm] depth underneath the tree), pinon pine shoots (PPS), and pinon pine nuts (PPN) collected from LANL lands and regional background (BG) locations, (2) concentrations of radionuclides in PPN collected in 1977 to present data, (3) committed effective dose equivalent (CEDE) from the ingestion of nuts, and (4) soil to PPS to PPN concentration ratios (CRs). Most radionuclides, with the exception of 3 H in soils, were not significantly higher (p < 0.10) in soils, PPS, and PPN collected from LANL as compared to BG locations, and concentrations of most radionuclides in PPN from LANL have decreased over time. The maximum net CEDE (the CEDE plus two sigma minus BG) at the most conservative ingestion rate (10 lb [4.5 kg]) was 0.0018 mrem (0.018 microSv). Soil-to-nut CRs for most radionuclides were within the range of default values in the literature for common fruits and vegetables

  14. A study of γ-ray source for the transmutation

    International Nuclear Information System (INIS)

    Nomura, Masahiro; Takahashi, Hiroshi.

    1996-07-01

    PNC is developing high power CW electron linac for various applications, those are the transmutation of the fission products, Free Electron Laser (FEL), the positron source and so on. Especially, the transmutation by the electron linac has been studied for several years. As the results, high flux and high energy γ-ray (∼15 MeV) is required, one of the big problems is that plenty of transmutation energy is needed and the narrow γ-ray energy spectrum can reduce the transmutation energy. The γ-rays can be produced by synchrotron radiation, FEL and laser compton scattering. Those methods were described briefly and compared. As a result, the laser compton scattering is one of the good methods to produce high energy γ-ray. However the cross section between electron and photon is small and the scattered photon energy spectrum is not so narrow that the transmutation energy is reduced drastically. To enhance the interaction between electron and photon, the super cavity is proposed. And some experiments are in progress. To reduce the transmutation energy, scattered electron must be reused by the storage ring. If the scattered electrons are not used for producing γ-ray, the efficiency is less than 1%. In our system, the efficiency can be increased to 20% by reusing scattered electrons. But this efficiency is still low. To increase the efficiency, the RF bucket must be enlarged. If the momentans compaction factor α can be reduced, the RF bucket can be enlarged. And the storage ring must be designed to have small value of the α. The electron energy dependency of efficiency is investigated, too. In short word, it is difficult to increase the efficiency drastically by changing electron energy. This work was conducted as a part of the collaboration work between PNC and BNL. (author)

  15. Golimumab in patients with active rheumatoid arthritis who have previous experience with tumour necrosis factor inhibitors: results of a long-term extension of the randomised, double-blind, placebo-controlled GO-AFTER study through week 160

    NARCIS (Netherlands)

    Smolen, Josef S.; Kay, Jonathan; Landewé, Robert B. M.; Matteson, Eric L.; Gaylis, Norman; Wollenhaupt, Jurgen; Murphy, Frederick T.; Zhou, Yiying; Hsia, Elizabeth C.; Doyle, Mittie K.

    2012-01-01

    The aim of this study was to assess long-term golimumab therapy in patients with rheumatoid arthritis (RA) who discontinued previous tumour necrosis factor alpha (TNFα) inhibitor(s) for any reason. Results through week 24 of this multicentre, randomised, double-blind, placebo-controlled study of

  16. Time-Reversal Study of the Hemet (CA) Tremor Source

    Science.gov (United States)

    Larmat, C. S.; Johnson, P. A.; Guyer, R. A.

    2010-12-01

    Since its first observation by Nadeau & Dolenc (2005) and Gomberg et al. (2008), tremor along the San Andreas fault system is thought to be a probe into the frictional state of the deep part of the fault (e.g. Shelly et al., 2007). Tremor is associated with slow, otherwise deep, aseismic slip events that may be triggered by faint signals such as passing waves from remote earthquakes or solid Earth tides.Well resolved tremor source location is key to constrain frictional models of the fault. However, tremor source location is challenging because of the high-frequency and highly-scattered nature of tremor signal characterized by the lack of isolated phase arrivals. Time Reversal (TR) methods are emerging as a useful tool for location. The unique requirement is a good velocity model for the different time-reversed phases to arrive coherently onto the source point. We present results of location for a tremor source near the town of Hemet, CA, which was triggered by the 2002 M 7.9 Denali Fault earthquake (Gomberg et al., 2008) and by the 2009 M 6.9 Gulf of California earthquake. We performed TR in a volume model of 88 (N-S) x 70 (W-E) x 60 km (Z) using the full-wave 3D wave-propagation package SPECFEM3D (Komatitsch et al., 2002). The results for the 2009 episode indicate a deep source (at about 22km) which is about 4km SW the fault surface scarp. We perform STA/SLA and correlation analysis in order to have independent confirmation of the Hemet tremor source. We gratefully acknowledge the support of the U. S. Department of Energy through the LANL/LDRD Program for this work.

  17. A study of potential sources of linguistic ambiguity in written work instructions.

    Energy Technology Data Exchange (ETDEWEB)

    Matzen, Laura E.

    2009-11-01

    This report describes the results of a small experimental study that investigated potential sources of ambiguity in written work instructions (WIs). The English language can be highly ambiguous because words with different meanings can share the same spelling. Previous studies in the nuclear weapons complex have shown that ambiguous WIs can lead to human error, which is a major cause for concern. To study possible sources of ambiguity in WIs, we determined which of the recommended action verbs in the DOE and BWXT writer's manuals have numerous meanings to their intended audience, making them potentially ambiguous. We used cognitive psychology techniques to conduct a survey in which technicians who use WIs in their jobs indicated the first meaning that came to mind for each of the words. Although the findings of this study are limited by the small number of respondents, we identified words that had many different meanings even within this limited sample. WI writers should pay particular attention to these words and to their most frequent meanings so that they can avoid ambiguity in their writing.

  18. Sustainability in Open Source Software Commons: Lessons Learned from an Empirical Study of SourceForge Projects

    Directory of Open Access Journals (Sweden)

    Charles M. Schweik

    2013-01-01

    Full Text Available In this article, we summarize a five-year US National Science Foundation funded study designed to investigate the factors that lead some open source projects to ongoing collaborative success while many others become abandoned. Our primary interest was to conduct a study that was closely representative of the population of open source software projects in the world, rather than focus on the more-often studied, high-profile successful cases. After building a large database of projects (n=174,333 and implementing a major survey of open source developers (n=1403, we were able to conduct statistical analyses to investigate over forty theoretically-based testable hypotheses. Our data firmly support what we call the conventional theory of open source software, showing that projects start small, and, in successful cases, grow slightly larger in terms of team size. We describe the “virtuous circle” supporting conventional wisdom of open source collaboration that comes out of this analysis, and we discuss two other interesting findings related to developer motivations and how team members find each other. Each of these findings is related to the sustainability of these projects.

  19. Feasibility study of broadband efficient ''water window'' source

    International Nuclear Information System (INIS)

    Higashiguchi, Takeshi; Yugami, Noboru; Otsuka, Takamitsu; Jiang Weihua; Endo, Akira; Li Bowen; Dunne, Padraig; O'Sullivan, Gerry

    2012-01-01

    We demonstrate a table-top broadband emission water window source based on laser-produced high-Z plasmas. Resonance emission from multiply charged ions merges to produce intense unresolved transition arrays (UTAs) in the 2-4 nm region, extending below the carbon K edge (4.37 nm). Arrays resulting from n=4-n=4 transitions are overlaid with n=4-n=5 emission and shift to shorter wavelength with increasing atomic number. An outline of a microscope design for single-shot live cell imaging is proposed based on a bismuth plasma UTA source, coupled to multilayer mirror optics.

  20. Tax evasion and income source: A comparative experimental study

    NARCIS (Netherlands)

    Gërxhani, K.; Schram, A.J.H.C.

    2006-01-01

    We compare tax evasive behavior in a country in transition from communism to that in a developed economy by running an experiment across distinct social groups in Albania and the Netherlands. Aside from the tax compliance decision, subjects choose a source of income, where one type enables

  1. Principal and experimental study of source of polarized electrons

    International Nuclear Information System (INIS)

    Shang Rencheng; Gao Junfang; Xiao Yuan; Pang Wenning; Deng Jingkang

    1999-01-01

    The getting of polarized electrons was briefly introduced, that is the source of polarized electrons. The measurement of polarization in future, the application of polarized electrons in atomic and molecular physics, condensed physics, biological physics, nuclear and particle physics were discussed

  2. Literature study of source term research for PWRs

    Energy Technology Data Exchange (ETDEWEB)

    Sponton, L.L.; NiIsson, Lars

    2001-04-01

    A literature survey has been carried out in support of ongoing source term calculations with the MELCOR code of some severe accident scenarios for the Swedish Ringhals 2 pressurised water reactor (PWR). The research in the field of severe accidents in power reactors and the source term for subsequent release of radioisotopes was intensified after the Harrisburg accident and has produced a large amount of reports and papers. This survey was therefore limited to research concerning PWR type of reactors and with emphasis on papers related to MELCOR code development. A background is given, relating to some historic documents, and then more recent research after 1990 is reviewed. Of special interest is the ongoing PMbus-programme which is creating new and important results of benefit to the code development and validation of, among others, the MELCOR code. It is concluded that source term calculations involve simulation of many interacting complex physical phenomena, which result in large uncertainties The research has, however, over the years led to considerable improvements Thus has the uncertainty in source term predictions been reduced one to two orders of magnitude from the simpler codes in the early 1980-s to the more realistic codes of today, like MELCOR.

  3. 61 SOURCE-CRITICAL STUDIES IN LUKE-ACTS: IMPLICATIONS ...

    African Journals Online (AJOL)

    HP

    its picture in the human mind.10 Social memory, especially in its wider concept of ... his sources, with special attention to their function and how they influenced Luke‟s narrative discourse. ..... But he also explicitly states his engagement in another dialogue ... some literary dependence without a clear dividing line. To have a ...

  4. Open Source Projects in Software Engineering Education: A Mapping Study

    Science.gov (United States)

    Nascimento, Debora M. C.; Almeida Bittencourt, Roberto; Chavez, Christina

    2015-01-01

    Context: It is common practice in academia to have students work with "toy" projects in software engineering (SE) courses. One way to make such courses more realistic and reduce the gap between academic courses and industry needs is getting students involved in open source projects (OSP) with faculty supervision. Objective: This study…

  5. Literature study of source term research for PWRs

    International Nuclear Information System (INIS)

    Sponton, L.L.; NiIsson, Lars

    2001-04-01

    A literature survey has been carried out in support of ongoing source term calculations with the MELCOR code of some severe accident scenarios for the Swedish Ringhals 2 pressurised water reactor (PWR). The research in the field of severe accidents in power reactors and the source term for subsequent release of radioisotopes was intensified after the Harrisburg accident and has produced a large amount of reports and papers. This survey was therefore limited to research concerning PWR type of reactors and with emphasis on papers related to MELCOR code development. A background is given, relating to some historic documents, and then more recent research after 1990 is reviewed. Of special interest is the ongoing PMbus-programme which is creating new and important results of benefit to the code development and validation of, among others, the MELCOR code. It is concluded that source term calculations involve simulation of many interacting complex physical phenomena, which result in large uncertainties The research has, however, over the years led to considerable improvements Thus has the uncertainty in source term predictions been reduced one to two orders of magnitude from the simpler codes in the early 1980-s to the more realistic codes of today, like MELCOR

  6. Study on a volume-production H- ion source

    International Nuclear Information System (INIS)

    Takama, S.

    1988-01-01

    H - ions formed by volume-production are extracted from a multicuspion source. By applying a large positive bias to the plasma electrode, the ratio I - /I e becomes 1/20. H - ion current of 0.4mA is extracted from a 0.3cm 2 circular aperture at an arc current of 10A. (author)

  7. Quasiballistic heat removal from small sources studied from first principles

    Science.gov (United States)

    Vermeersch, Bjorn; Mingo, Natalio

    2018-01-01

    Heat sources whose characteristic dimension R is comparable to phonon mean free paths display thermal resistances that exceed conventional diffusive predictions. This has direct implications to (opto)electronics thermal management and phonon spectroscopy. Theoretical analyses have so far limited themselves to particular experimental configurations. Here, we build upon the multidimensional Boltzmann transport equation (BTE) to derive universal expressions for the apparent conductivity suppression S (R ) =κeff(R ) /κbulk experienced by radially symmetric 2D and 3D sources. In striking analogy to cross-plane heat conduction in thin films, a distinct quasiballistic regime emerges between ballistic (κeff˜R ) and diffusive (κeff≃κbulk ) asymptotes that displays a logarithmic dependence κeff˜ln(R ) in single crystals and fractional power dependence κeff˜R2 -α in alloys (with α the Lévy superdiffusion exponent). Analytical solutions and Monte Carlo simulations for spherical and circular heat sources in Si, GaAs, Si0.99Ge0.01 , and Si0.82Ge0.18 , all carried out from first principles, confirm the predicted generic tendencies. Contrary to the thin film case, common approximations like kinetic theory estimates κeff≃∑Sωgreyκω and modified Fourier temperature curves perform relatively poorly. Up to threefold deviations from the BTE solutions for sub-100 nm sources underline the need for rigorous treatment of multidimensional nondiffusive transport.

  8. Study on recriticality of fuel debris during hypothetical severe accidents in the Advanced Neutron Source reactor

    International Nuclear Information System (INIS)

    Kim, S.H.; Taleyarkhan, R.P.; Georgevich, V.; Navarro-Valenti, S.; Shin, S.T.

    1995-09-01

    A study has been performed to measure the potential of recriticality during hypothetical severe accident in Advanced Neutron Source (ANS). For the lumped debris configuration in the Reactor Coolant System (RCS), as found in the previous study, recriticality potential may be very low. However, if fuel debris is dispersed and mixed with heavy water in RCS, recriticality potential has been predicted to be substantial depending on thermal-hydraulic conditions surrounding fuel debris mixture. The recriticality potential in RCS is substantially reduced for the three element core design with 50% enrichment. Also, as observed in the previous study, strong dependencies of k eff on key thermal hydraulic parameters are shown. Light water contamination is shown to provide a positive reactivity, and void formation due to boiling of mixed water provides enough negative reactivity and to bring the system down to subcritical. For criticality potential in the subpile room, the lumped debris configuration does not pose a concern. Dispersed configuration in light water pool of the subpile room is also unlikely to result in criticality. However, if the debris is dispersed in the pool that is mixed with heavy water, the results indicate that a substantial potential exists for the debris to reach the criticality. However, if prompt recriticality disperses the debris completely in the subpile room pool, subsequent recriticality may be prevented since neutron leakage effects become large enough

  9. A characterization and optimization study of Gamble II as an X-ray bremsstrahlung source

    International Nuclear Information System (INIS)

    Oliphant, W.F.; Boller, J.R.; Brown, D.G.; Cooperstein, G.; Dozier, C.M.; Stephanakis, S.J.

    1982-01-01

    The adverse effects of radiation on solid state devices are strongly spectrum dependent. It is thus essential that the radiation spectrum from flash x-ray sources be available when they are used as facilities for testing electronic components. This paper describes a preliminary study in which previously developed computer codes were used to calculate the radiation spectrum produced by NRL's Gamble II pulsed power generator. To determine how well the calculated spectrum matched the experimental one, doses in CaF 2 -Mn TLD's were computed for the dosimeters placed behind various thicknesses of Cu and Pb filters and compared with the experimentally measured doses. Using a diode model that was consistent with presently understood electron beam behavior, a spectrum was generated which predicted TLD doses to within about 15% of the experimentally measured values

  10. Photoionization mass spectrometer for studies of flame chemistry with a synchrotron light source

    International Nuclear Information System (INIS)

    Cool, Terrill A.; McIlroy, Andrew; Qi, Fei; Westmoreland, Phillip R.; Poisson, Lionel; Peterka, Darcy S.; Ahmed, Musahid

    2005-01-01

    A flame-sampling molecular-beam photoionization mass spectrometer, recently designed and constructed for use with a synchrotron-radiation light source, provides significant improvements over previous molecular-beam mass spectrometers that have employed either electron-impact ionization or vacuum ultraviolet laser photoionization. These include superior signal-to-noise ratio, soft ionization, and photon energies easily and precisely tunable [E/ΔE(FWHM)≅250-400] over the 7.8-17-eV range required for quantitative measurements of the concentrations and isomeric compositions of flame species. Mass resolution of the time-of-flight mass spectrometer is m/Δm=400 and sensitivity reaches ppm levels. The design of the instrument and its advantages for studies of flame chemistry are discussed

  11. Study on induced radioactivity of China Spallation Neutron Source

    International Nuclear Information System (INIS)

    Wu Qingbiao; Wang Qingbin; Wu Jingmin; Ma Zhongjian

    2011-01-01

    China Spallation Neutron Source (CSNS) is the first High Energy Intense Proton Accelerator planned to be constructed in China during the State Eleventh Five-Year Plan period, whose induced radioactivity is very important for occupational disease hazard assessment and environmental impact assessment. Adopting the FLUKA code, the authors have constructed a cylinder-tunnel geometric model and a line-source sampling physical model, deduced proper formulas to calculate air activation, and analyzed various issues with regard to the activation of different tunnel parts. The results show that the environmental impact resulting from induced activation is negligible, whereas the residual radiation in the tunnels has a great influence on maintenance personnel, so strict measures should be adopted.(authors)

  12. Subsequent pregnancy outcome after previous foetal death

    NARCIS (Netherlands)

    Nijkamp, J. W.; Korteweg, F. J.; Holm, J. P.; Timmer, A.; Erwich, J. J. H. M.; van Pampus, M. G.

    Objective: A history of foetal death is a risk factor for complications and foetal death in subsequent pregnancies as most previous risk factors remain present and an underlying cause of death may recur. The purpose of this study was to evaluate subsequent pregnancy outcome after foetal death and to

  13. Source apportionment studies on particulate matter in Beijing/China

    Science.gov (United States)

    Suppan, P.; Shen, R.; Shao, L.; Schrader, S.; Schäfer, K.; Norra, S.; Vogel, B.; Cen, K.; Wang, Y.

    2013-05-01

    More than 15 million people in the greater area of Beijing are still suffering from severe air pollution levels caused by sources within the city itself but also from external impacts like severe dust storms and long range advection from the southern and central part of China. Within this context particulate matter (PM) is the major air pollutant in the greater area of Beijing (Garland et al., 2009). PM did not serve only as lead substance for air quality levels and therefore for adverse health impact effects but also for a strong influence on the climate system by changing e.g. the radiative balance. Investigations on emission reductions during the Olympic Summer Games in 2008 have caused a strong reduction on coarser particles (PM10) but not on smaller particles (PM2.5). In order to discriminate the composition of the particulate matter levels, the different behavior of coarser and smaller particles investigations on source attribution, particle characteristics and external impacts on the PM levels of the city of Beijing by measurements and modeling are performed: a) Examples of long term measurements of PM2.5 filter sampling in 2010/2011 with the objectives of detailed chemical (source attribution, carbon fraction, organic speciation and inorganic composition) and isotopic analyses as well as toxicological assessment in cooperation with several institutions (Karlsruhe Institute of Technology (IfGG/IMG), Helmholtz Zentrum München (HMGU), University Rostock (UR), Chinese University of Mining and Technology Beijing, CUMTB) will be discussed. b) The impact of dust storm events on the overall pollution level of particulate matter in the greater area of Beijing is being assessed by the online coupled comprehensive model system COSMO-ART. First results of the dust storm modeling in northern China (2011, April 30th) demonstrates very well the general behavior of the meteorological parameters temperature and humidity as well as a good agreement between modeled and

  14. Antenatal surveillance through estimates of the sources underlying the abdominal phonogram: a preliminary study

    International Nuclear Information System (INIS)

    Jiménez-González, A; James, C J

    2013-01-01

    Today, it is generally accepted that current methods for biophysical antenatal surveillance do not facilitate a comprehensive and reliable assessment of foetal well-being and that continuing research into alternative methods is necessary to improve antenatal monitoring procedures. In our research, attention has been paid to the abdominal phonogram, a signal that is recorded by positioning an acoustic sensor on the maternal womb and contains valuable information about foetal status, but which is hidden by maternal and environmental sources. To recover such information, previous work has used single-channel independent component analysis (SCICA) on the abdominal phonogram and successfully retrieved estimates of the foetal phonocardiogram, the maternal phonocardiogram, the maternal respirogram and noise. The availability of these estimates made it possible for the current study to focus on their evaluation as sources for antenatal surveillance purposes. To this end, the foetal heart rate (FHR), the foetal heart sounds morphology, the maternal heart rate (MHR) and the maternal breathing rate (MBR) were collected from the estimates retrieved from a dataset of 25 abdominal phonograms. Next, these parameters were compared with reference values to quantify the significance of the physiological information extracted from the estimates. As a result, it has been seen that the instantaneous FHR, the instantaneous MHR and the MBR collected from the estimates consistently followed the trends given by the reference signals, which is a promising outcome for this preliminary study. Thus, as far as this study has gone, it can be said that the independent traces retrieved by SCICA from the abdominal phonogram are likely to become valuable sources of information for well-being surveillance, both foetal and maternal. (paper)

  15. Overview of the Lombardy Region (I) Source Apportionment Study

    Science.gov (United States)

    Larsen, B. R.

    2009-04-01

    The Lombardia Region (RL) is situated in the central part of the Po Plain (I) where the mesoscale climatological conditions are determined to a high degree by the orographical characteristics of this area. Encirclement from three sides (North, West and South) by the mountain chains contributes greatly to the climatological peculiarities that are related from the physical point of view to the dynamic of the air mass in this region. The adverse anemological regime and the persistence of atmospheric stability result in low wind speeds, inversion of the temperature, and shallow inversion layers. Due to these particular geographical and the meteorological conditions associated with a high population density (9 million inhabitants) and the connected anthropogenic activities, RL is one of Europe's most polluted regions with regard to PM and photochemical smog. The 24 hours EU air quality limit for PM10 of 50 ug/m3 is exceeded up to 180 days per year and the yearly limit of 40 ug/m3 is in breach for most urban/urban background areas. In order to efficiently plan abatement strategies, quantitative information is required on the pollution sources and available emission inventories need to be compared with source apportionment results derived by receptor modeling of the chemical composition of PM10 in ambient air and in source emissions. The European Commission Joint Research Centre (JRC) has embarked on a major integrated project in RL (2006-2010) in collaboration with the air quality authorities (ARPA) to support the design of appropriate air quality and emission reduction strategies in this area. The present paper presents the first results of this project, carried out during typical winter episodes in 2007 at ten measurement stations distributed over the entire RL. The source contributions to PM10 and the associated air toxics (benzo[a]pyrene, Pb, Ni, Cd and As) have been quantified by Chemical Mass Balance and Positive Matrix Factorization based upon the chemical

  16. Global Source Parameters from Regional Spectral Ratios for Yield Transportability Studies

    Science.gov (United States)

    Phillips, W. S.; Fisk, M. D.; Stead, R. J.; Begnaud, M. L.; Rowe, C. A.

    2016-12-01

    We use source parameters such as moment, corner frequency and high frequency rolloff as constraints in amplitude tomography, ensuring that spectra of well-studied earthquakes are recovered using the ensuing attenuation and site term model. We correct explosion data for path and site effects using such models, which allows us to test transportability of yield estimation techniques based on our best source spectral estimates. To develop a background set of source parameters, we applied spectral ratio techniques to envelopes of a global set of regional distance recordings from over 180,000 crustal events. Corner frequencies and moment ratios were determined via inversion using all event pairs within predetermined clusters, shifting to absolute levels using independently determined regional and teleseismic moments. The moment and corner frequency results can be expressed as stress drop, which has considerable scatter, yet shows dramatic regional patterns. We observe high stress in subduction zones along S. America, S. Mexico, the Banda Sea, and associated with the Yakutat Block in Alaska. We also observe high stress at the Himalayan syntaxes, the Pamirs, eastern Iran, the Caspian, the Altai-Sayan, and the central African rift. Low stress is observed along mid ocean spreading centers, the Afar rift, patches of convergence zones such as Nicaragua, the Zagros, Tibet, and the Tien Shan, among others. Mine blasts appear as low stress events due to their low corners and steep rolloffs. Many of these anomalies have been noted by previous studies, and we plan to compare results directly. As mentioned, these results will be used to constrain tomographic imaging, but can also be used in model validation procedures similar to the use of ground truth in location problems, and, perhaps most importantly, figure heavily in quality control of local and regional distance amplitude measurements.

  17. STUDIES OF SHADING LEVELS AND NUTRITION SOURCES ON GROWTH, YIELD

    Directory of Open Access Journals (Sweden)

    Edi Purwanto

    2011-10-01

    Full Text Available Growth and biochemical content of medicinal crops are influenced by agroecosystems characteristics . The objective of this research was to determine the optimum shading level and type of fertilizer as sources of nutrition on the growth, yield, and andrographolide content of sambiloto. The experiment used Split Plot Design with basic design of Randomized Complete Block Design arranged with two treatment factors, with three replications. The first factor as the main plot was shading levels, namely without shading, 25% shading, 50% shading, and 75% shading. The second factor as the sub plot was sources of nutrition reprented by type of fertilizer, namely NPK fertilizer, cow stable fertilizer, and compost fertilizer. The result of research indicated that shading level and the kind of nutrition influenced some growth and yield variables such as number of leaves, number of branches, plant height, plant dry weight and simplisia weight, and andrographolide content. Interaction of shading level at 25% and straw compost fertilizer performed best in growth characteristics, while the highest andrographolide content resulted from the treatment combination of 50% shading level and straw compost fertilizer.

  18. Study of Coal Burst Source Locations in the Velenje Colliery

    Directory of Open Access Journals (Sweden)

    Goran Vižintin

    2016-06-01

    Full Text Available The Velenje coal mine (VCM is situated on the largest Slovenian coal deposit and in one of the thickest layers of coal known in the world. The thickness of the coal layer causes problems for the efficiency of extraction, since the majority of mining operations is within the coal layer. The selected longwall coal mining method with specific geometry, increasing depth of excavations, changes in stress state and naturally given geomechanical properties of rocks induce seismic events. Induced seismic events can be caused by caving processes, blasting or bursts of coal or the surrounding rock. For 2.5D visualization, data of excavations, ash content and calorific value of coal samples, hanging wall and footwall occurrence, subsidence of the surface and coal burst source locations were collected. Data and interpolation methods available in software package Surfer®12 were statistically analyzed and a Kriging (KRG interpolation method was chosen. As a result 2.5D visualizations of coal bursts source locations with geomechanical properties of coal samples taken at different depth in the coal seam in the VCM were made with data-visualization packages Surfer®12 and Voxler®3.

  19. A study about ions sources for solids and gases

    International Nuclear Information System (INIS)

    Perez Z, E.

    1975-01-01

    Description of the different ways of obtaining ions and the causes which limits their production is covered among the various possible combinations of parameters involved in any source in order to obtain the maximum current of ions, the following were selected: filament current against: focusing voltage and accelerating voltage, establishing also a ions current relationship between detectors. In the first pair of parameters, the increase of the accelerating voltage produced the increase of the ionization current and similarly in the second and third pair of parameters the increase of the filament current and pression respectively produced the same effect. During the separation between the discharge camera and lens it was observed that to each variation in the extraction voltage corresponded an equal variation in the focusing voltage. Finally a relationship was established in the ions current between grating and detector in order to determine the more appropriate distance between the camera and the focusing lens. The increase of the ionization current when the accelerating voltage, the magnetic field and the gas pressure are increased is interpreted as a physical fact; the efficiency of a source is considered. (author)

  20. Optimisation studies for a moderator on a pulsed neutron source

    International Nuclear Information System (INIS)

    Picton, D.J.; Ross, D.K.; Taylor, A.D.

    1982-01-01

    Having reviewed general aspects of moderator design for pulsed neutron sources, calculations are presented on a number of aspects of moderator optimization. Results of time-independent calculations on metal hydride moderators and a detailed method of evaluating moderated pulse intensities and time distributions, are given. Using computer codes, neutron cross-sections have been calculated from vibrational frequency distributions and time-dependent moderator calculations performed by Monte Carlo methods. The choice of an ambient moderator material and the optimum configuration of heterogeneous poisoning are examined and evaluations of liquid-nitrogen-cooled moderators are presented. Conclusions are drawn concerning the relative merits of cooled and poisoned moderators and an evaluation presented of solid methane at 20 K as a moderator for the production of cold neutrons. (U.K.)

  1. Capitalization of renewable energy sources: Romanian case studies

    International Nuclear Information System (INIS)

    Voronca, Mihai-Marius; Cruceru, Mihai

    2007-01-01

    One of the major challenges of the recent integration of Romania in the European Union is the extension of use, at national scale, of Renewable Energy Sources (RES). Targeting private operators and municipalities, authors have as objective to deliver an investigation on the interesting 'Acquis' in financing and implementing RES projects in Romania. Using as method of investigation the accurate screening of their experience as well as the extended international experience in the field, authors have reviewed in the present paper different possibilities in RES investment financing, frequent obstacles and barriers, and ways for overcoming them. Recent results are motivating authors to consider the national experience of an encouraging success and to act towards the capitalization of such investments replication potential to a national and regional scale. (authors)

  2. Study on analysis from sources of error for Airborne LIDAR

    Science.gov (United States)

    Ren, H. C.; Yan, Q.; Liu, Z. J.; Zuo, Z. Q.; Xu, Q. Q.; Li, F. F.; Song, C.

    2016-11-01

    With the advancement of Aerial Photogrammetry, it appears that to obtain geo-spatial information of high spatial and temporal resolution provides a new technical means for Airborne LIDAR measurement techniques, with unique advantages and broad application prospects. Airborne LIDAR is increasingly becoming a new kind of space for earth observation technology, which is mounted by launching platform for aviation, accepting laser pulses to get high-precision, high-density three-dimensional coordinate point cloud data and intensity information. In this paper, we briefly demonstrates Airborne laser radar systems, and that some errors about Airborne LIDAR data sources are analyzed in detail, so the corresponding methods is put forwarded to avoid or eliminate it. Taking into account the practical application of engineering, some recommendations were developed for these designs, which has crucial theoretical and practical significance in Airborne LIDAR data processing fields.

  3. Experimental Study of a Positron\\\\ Source Using Channeling

    CERN Multimedia

    Gavrykov, V; Kulibaba, V; Baier, V; Beloborodov, K; Bojenok, A; Bukin, A; Burdin, S; Dimova, T; Druzhinin, V; Dubrovin, M; Seredniakov, S; Shary, V; Strakhovenko, V; Keppler, P; Major, J; Bogdanov, A V; Potylitsin, A; Vnoukov, I; Artru, X; Lautesse, P; Poizat, J-C; Remillieux, J

    2002-01-01

    Many simulations have predicted that the yield of positrons, resulting from the interaction of fast electrons in a solid target, increases if the target is a crystal oriented with a major axis parallel to the electron beam. Tests made at Orsay and Tokyo confirmed these expectations. The experiment WA 103 concerns the determination of the main characteristics (emittance, energy spread) of a crystal positron source which could replace advantageously the conventional positron converters foreseen in some linear collider projects. The main element of the set-up is a magnetic spectrometer, using a drift chamber, where the positron trajectories are reconstructed (see Figure 1) A first run has been operated in july 2000 and the first results showed, as expected, a significant enhancement in photon and positron generation along the $$ axis of the tungsten crystal. Indications about a significant increase in the number of soft photons and positrons were also gathered : this point is of importance for the positron colle...

  4. Multiwavelength study of Chandra X-ray sources in the Antennae

    Science.gov (United States)

    Clark, D. M.; Eikenberry, S. S.; Brandl, B. R.; Wilson, J. C.; Carson, J. C.; Henderson, C. P.; Hayward, T. L.; Barry, D. J.; Ptak, A. F.; Colbert, E. J. M.

    2011-01-01

    We use Wide-field InfraRed Camera (WIRC) infrared (IR) images of the Antennae (NGC 4038/4039) together with the extensive catalogue of 120 X-ray point sources to search for counterpart candidates. Using our proven frame-tie technique, we find 38 X-ray sources with IR counterparts, almost doubling the number of IR counterparts to X-ray sources that we first identified. In our photometric analysis, we consider the 35 IR counterparts that are confirmed star clusters. We show that the clusters with X-ray sources tend to be brighter, Ks≈ 16 mag, with (J-Ks) = 1.1 mag. We then use archival Hubble Space Telescope (HST) images of the Antennae to search for optical counterparts to the X-ray point sources. We employ our previous IR-to-X-ray frame-tie as an intermediary to establish a precise optical-to-X-ray frame-tie with <0.6 arcsec rms positional uncertainty. Due to the high optical source density near the X-ray sources, we determine that we cannot reliably identify counterparts. Comparing the HST positions to the 35 identified IR star cluster counterparts, we find optical matches for 27 of these sources. Using Bruzual-Charlot spectral evolutionary models, we find that most clusters associated with an X-ray source are massive, and young, ˜ 106 yr.

  5. Study of the Dissociative Processes in O_2 Discharges. Development of an Atomic Oxygen Beam Source

    International Nuclear Information System (INIS)

    Pagnon, Daniel

    1992-01-01

    The first part of this work is devoted to the study of dissociative processes in an oxygen glow discharge at low pressure (0,1-5 Torr, 1-80 mA). The kinetics of oxygen atoms has been determined supported by the measurements of atomic concentrations by VUV absorption spectroscopy and actinometry. The reaction coefficients for dissociative excitation and direct excitation of oxygen atoms have been calculated using the cross sections of the literature and a previously calculated EEDF. It has been demonstrated that dissociative excitation is negligible in respect with direct excitation for dissociation rates smaller than 2,5 %. An upper limit of 20 % for dissociative rates is observed. This limit has been explained by the increase of the atomic recombination at the discharge wall with increasing wall temperature. Using all these results, we have designed and optimized a source of oxygen atoms which has then been adapted on a MBE device. The spatial distribution of the atomic density has been measured in molecular jet by laser induced fluorescence (LIF) and Resonant Multi-Photon Ionization (RMPI). A stimulated emission has been evidenced and the coefficient for this process evaluated. A model for the effusion of atoms has been developed from which the flow of atoms on the sample can be predicted. This source has already been used in industrial MBE devices for in-situ oxidation of copper films, superconductors, and substrates for VLSI high speed applications. The methodology of this work and the diagnostics developed can be applied to other kinds of discharges, of other molecular gases, to design sources of atoms for the treatment of large area samples. (author) [fr

  6. A comparison study on various low energy sources in interstitial prostate brachytherapy

    Directory of Open Access Journals (Sweden)

    Mahdi Bakhshabadi

    2016-02-01

    Full Text Available Purpose: Low energy sources are routinely used in prostate brachytherapy. 125 I is one of the most commonly used sources. Low energy 131 Cs source was introduced recently as a brachytherapy source. The aim of this study is to compare dose distributions of 125 I, 103 Pd, and 131 Cs sources in interstitial brachytherapy of prostate. Material and methods: ProstaSeed 125 I brachytherapy source was simulated using MCNPX Monte Carlo code. Additionally, two hypothetical sources of 103 Pd and 131 Cs were simulated with the same geometry as the ProstaSeed 125 I source, while having their specific emitted gamma spectra. These brachytherapy sources were simulated with distribution of forty-eight seeds in a phantom including prostate. The prostate was considered as a sphere with radius of 1.5 cm. Absolute and relative dose rates were obtained in various distances from the source along the transverse and longitudinal axes inside and outside the tumor. Furthermore, isodose curves were plotted around the sources. Results : Analyzing the initial dose profiles for various sources indicated that with the same time duration and air kerma strength, 131 Cs delivers higher dose to tumor. However, relative dose rate inside the tumor is higher and outside the tumor is lower for the 103 Pd source. Conclusions : The higher initial absolute dose in cGy/(h.U of 131 Cs brachytherapy source is an advantage of this source over the others. The higher relative dose inside the tumor and lower relative dose outside the tumor for the 103 Pd source are advantages of this later brachytherapy source. Based on the total dose the 125 I source has advantage over the others due to its longer half-life.

  7. A comparison study on various low energy sources in interstitial prostate brachytherapy.

    Science.gov (United States)

    Bakhshabadi, Mahdi; Ghorbani, Mahdi; Khosroabadi, Mohsen; Knaup, Courtney; Meigooni, Ali S

    2016-02-01

    Low energy sources are routinely used in prostate brachytherapy. (125)I is one of the most commonly used sources. Low energy (131)Cs source was introduced recently as a brachytherapy source. The aim of this study is to compare dose distributions of (125)I, (103)Pd, and (131)Cs sources in interstitial brachytherapy of prostate. ProstaSeed (125)I brachytherapy source was simulated using MCNPX Monte Carlo code. Additionally, two hypothetical sources of (103)Pd and (131)Cs were simulated with the same geometry as the ProstaSeed (125)I source, while having their specific emitted gamma spectra. These brachytherapy sources were simulated with distribution of forty-eight seeds in a phantom including prostate. The prostate was considered as a sphere with radius of 1.5 cm. Absolute and relative dose rates were obtained in various distances from the source along the transverse and longitudinal axes inside and outside the tumor. Furthermore, isodose curves were plotted around the sources. Analyzing the initial dose profiles for various sources indicated that with the same time duration and air kerma strength, (131)Cs delivers higher dose to tumor. However, relative dose rate inside the tumor is higher and outside the tumor is lower for the (103)Pd source. The higher initial absolute dose in cGy/(h.U) of (131)Cs brachytherapy source is an advantage of this source over the others. The higher relative dose inside the tumor and lower relative dose outside the tumor for the (103)Pd source are advantages of this later brachytherapy source. Based on the total dose the (125)I source has advantage over the others due to its longer half-life.

  8. Nutrient patterns and their food sources in an International Study Setting: report from the EPIC study.

    Science.gov (United States)

    Moskal, Aurelie; Pisa, Pedro T; Ferrari, Pietro; Byrnes, Graham; Freisling, Heinz; Boutron-Ruault, Marie-Christine; Cadeau, Claire; Nailler, Laura; Wendt, Andrea; Kühn, Tilman; Boeing, Heiner; Buijsse, Brian; Tjønneland, Anne; Halkjær, Jytte; Dahm, Christina C; Chiuve, Stephanie E; Quirós, Jose R; Buckland, Genevieve; Molina-Montes, Esther; Amiano, Pilar; Huerta Castaño, José M; Gurrea, Aurelio Barricarte; Khaw, Kay-Tee; Lentjes, Marleen A; Key, Timothy J; Romaguera, Dora; Vergnaud, Anne-Claire; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Sacerdote, Carlotta; de Magistris, Maria Santucci; Bueno-de-Mesquita, H Bas; Ocké, Marga C; Beulens, Joline W J; Ericson, Ulrika; Drake, Isabel; Nilsson, Lena M; Winkvist, Anna; Weiderpass, Elisabete; Hjartåker, Anette; Riboli, Elio; Slimani, Nadia

    2014-01-01

    Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses. We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study and used 24-hour dietary recall (24-HDR) data to validate and describe the nutrient patterns and their related food sources. Associations between lifestyle factors and the nutrient patterns were also examined. Principal component analysis (PCA) was applied on 23 nutrients derived from country-specific FFQ combining data from all EPIC centers (N = 477,312). Harmonized 24-HDRs available for a representative sample of the EPIC populations (N = 34,436) provided accurate mean group estimates of nutrients and foods by quintiles of pattern scores, presented graphically. An overall PCA combining all data captured a good proportion of the variance explained in each EPIC center. Four nutrient patterns were identified explaining 67% of the total variance: Principle component (PC) 1 was characterized by a high contribution of nutrients from plant food sources and a low contribution of nutrients from animal food sources; PC2 by a high contribution of micro-nutrients and proteins; PC3 was characterized by polyunsaturated fatty acids and vitamin D; PC4 was characterized by calcium, proteins, riboflavin, and phosphorus. The nutrients with high loadings on a particular pattern as derived from country-specific FFQ also showed high deviations in their mean EPIC intakes by quintiles of pattern scores when estimated from 24-HDR. Center and energy intake explained most of the variability in pattern scores. The use of 24-HDR enabled internal validation and facilitated the interpretation of the nutrient patterns derived from FFQs in term of food sources. These outcomes open research opportunities and

  9. Nutrient patterns and their food sources in an International Study Setting: report from the EPIC study.

    Directory of Open Access Journals (Sweden)

    Aurelie Moskal

    Full Text Available Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses.We identified nutrient patterns from food frequency questionnaires (FFQ in the European Prospective Investigation into Cancer and Nutrition (EPIC Study and used 24-hour dietary recall (24-HDR data to validate and describe the nutrient patterns and their related food sources. Associations between lifestyle factors and the nutrient patterns were also examined. Principal component analysis (PCA was applied on 23 nutrients derived from country-specific FFQ combining data from all EPIC centers (N = 477,312. Harmonized 24-HDRs available for a representative sample of the EPIC populations (N = 34,436 provided accurate mean group estimates of nutrients and foods by quintiles of pattern scores, presented graphically. An overall PCA combining all data captured a good proportion of the variance explained in each EPIC center. Four nutrient patterns were identified explaining 67% of the total variance: Principle component (PC 1 was characterized by a high contribution of nutrients from plant food sources and a low contribution of nutrients from animal food sources; PC2 by a high contribution of micro-nutrients and proteins; PC3 was characterized by polyunsaturated fatty acids and vitamin D; PC4 was characterized by calcium, proteins, riboflavin, and phosphorus. The nutrients with high loadings on a particular pattern as derived from country-specific FFQ also showed high deviations in their mean EPIC intakes by quintiles of pattern scores when estimated from 24-HDR. Center and energy intake explained most of the variability in pattern scores.The use of 24-HDR enabled internal validation and facilitated the interpretation of the nutrient patterns derived from FFQs in term of food sources. These outcomes open research

  10. Columnar modelling of nucleation burst evolution in the convective boundary layer – first results from a feasibility study Part IV: A compilation of previous observations for valuation of simulation results from a columnar modelling study

    Directory of Open Access Journals (Sweden)

    O. Hellmuth

    2006-01-01

    according to the parameterisation of the collision-controlled binary nucleation rate proposed by Weber et al. (1996, H2O vapour does not explicitly affect the particle formation. Since the H2SO4 concentration is overpredicted in the simulations presented in Paper III, the nucleation rates are too high compared to previous estimations. Therefore, the results are not directly comparable to measurements. Especially NPF events, where organics are suspected to play a key role, such as those observed at the boreal forest station in Hyytiälä (Southern Finland or at Hohenpeissenberg (mountain site in Southern Germany, can not be explained by employing simple sulphur/ammonia chemistry. However, some valuable hints regarding the role of CBL turbulence in NPF can be obtained. In the literature a number of observations on the link between turbulence and NPF can be found, whose burst patterns support a strong contribution of CBL turbulence to the NPF burst evolution simulated here. Observations, that do not correspond to the scenarios are discussed with respect to possible reasons for the differences between model and observation. The model simulations support some state-of-the-art hypotheses on the contribution of CBL turbulence to NPF. Considering the application of box models, the present study shows, that CBL turbulence, not explicitly considered in such models, can strongly affect the spatio-temporal NPF burst evolution. The columnar high-order model presented here is a helpful tool to elucidate gas-aerosol-turbulence interactions, especially the genesis of NPF bursts in the CBL. An advanced description of the cluster formation and condensation growth is required as well as a comprehensive verification/validation study using observed high-order moments. Further scenario simulations remain to be performed.

  11. COMPARATIVE STUDY OF LUNAR ROUGHNESS FROM MULTI - SOURCE DATA

    Directory of Open Access Journals (Sweden)

    Y. Lou

    2017-07-01

    Full Text Available The lunar terrain can show its collision and volcanic history. The lunar surface roughness can give a deep indication of the effects of lunar surface magma, sedimentation and uplift. This paper aims to get different information from the roughness through different data sources. Besides introducing the classical Root-mean-square height method and Morphological Surface Roughness (MSR algorithm, this paper takes the area of the Jurassic mountain uplift in the Sinus Iridum and the Plato Crater area as experimental areas. And then make the comparison and contrast of the lunar roughness derived from LRO's DEM and CE-2 DOM. The experimental results show that the roughness obtained by the traditional roughness calculation method reflect the ups and downs of the topography, while the results obtained by morphological surface roughness algorithm show the smoothness of the lunar surface. So, we can first use the surface fluctuation situation derived from RMSH to select the landing area range which ensures the lands are gentle. Then the morphological results determine whether the landing area is suitable for the detector walking and observing. The results obtained at two different scales provide a more complete evaluation system for selecting the landing site of the lunar probe.

  12. Linac Coherent Light Source (LCLS) design study report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The Stanford Linear Accelerator Center (SLAC), in collaboration with Los Alamos National Laboratory, Lawrence Livermore National Laboratory, and the University of California at Los Angeles, is proposing to build a Free-Electron-Laser (FEL) R and D facility operating in the self-amplified spontaneous emission (SASE) mode in the wavelength range 1.5--15 {angstrom}. This FEL, called Linac Coherent Light Source (LCLS), utilizes the SLAC linac and produces sub-picosecond pulses of short wavelength x-rays with very high peak brightness and full transverse coherence. In this report, the Design Team has established performance parameters for all the major components of the LCLS and developed a layout of the entire system. Chapter 1 is the Executive Summary. Chapter 2 (Overview) provides a brief description of each of the major sections of the LCLS, from the rf photocathode gun, through the experimental stations and electron beam dump. Chapter 3 describes the scientific case for the LCLS. Chapter 4 provides a review of the principles of the FEL physics that the LCLS is based on, and Chapter 5 discusses the choice of the system's physical parameters. Chapters 6 through 10 describe in detail each major element of the system. Chapters 11 through 13 respectively cover undulator controls, mechanical alignment, and radiation issues.

  13. Dynamic sheath studies in plasma source ion implantation

    International Nuclear Information System (INIS)

    Schever, J.T.; Shamim, M.; Conrad, J.R.

    1990-01-01

    Plasma Source Ion Implantation (PSII) is a non-line-of-sight method for materials processing in which a target is immersed in a plasma and pulse biased to a high negative voltage (∼ 50 kV). A model of the dynamic sheath which forms under these conditions has been developed and applied to planar, cylindrical and spherical geometries. This model assumes that the transient sheath obeys the Child-Langmuir law for space charge limited emission at each instant during the propagation. Ions uncovered by the propagating sheath edge supply the space charge limited current. This yields an equation relating sheath edge velocity to position, which can be integrated to obtain the sheath edge position as a function of time. The same procedure used in cylindrical and spherical geometry results in a similar equation which must be integrated numerically. Comparison of results of experimental measurements, our model and simulation will be presented for the dynamic sheath edge position and target current waveform. Measurements of implanted dose uniformity of wedge shaped targets are also presented

  14. Microjet burners for molecular-beam sources and combustion studies

    Science.gov (United States)

    Groeger, Wolfgang; Fenn, John B.

    1988-09-01

    A novel microjet burner is described in which combustion is stabilized by a hot wall. The scale is so small that the entire burner flow can be passed through a nozzle only 0.2 mm or less in diameter into an evacuated chamber to form a supersonic free jet with expansion so rapid that all collisional processes in the jet gas are frozen in a microsecond or less. This burner can be used to provide high-temperature source gas for free jet expansion to produce intense beams of internally hot molecules. A more immediate use would seem to be in the analysis of combustion products and perhaps intermediates by various kinds of spectroscopies without some of the perturbation effects encountered in probe sampling of flames and other types of combustion devices. As an example of the latter application of this new tool, we present infrared emission spectra for jet gas obtained from the combustion of oxygen-hydrocarbon mixtures both fuel-rich and fuel-lean operation. In addition, we show results obtained by mass spectrometric analysis of the combustion products.

  15. Linac Coherent Light Source (LCLS) design study report

    International Nuclear Information System (INIS)

    1998-04-01

    The Stanford Linear Accelerator Center (SLAC), in collaboration with Los Alamos National Laboratory, Lawrence Livermore National Laboratory, and the University of California at Los Angeles, is proposing to build a Free-Electron-Laser (FEL) R and D facility operating in the self-amplified spontaneous emission (SASE) mode in the wavelength range 1.5--15 angstrom. This FEL, called Linac Coherent Light Source (LCLS), utilizes the SLAC linac and produces sub-picosecond pulses of short wavelength x-rays with very high peak brightness and full transverse coherence. In this report, the Design Team has established performance parameters for all the major components of the LCLS and developed a layout of the entire system. Chapter 1 is the Executive Summary. Chapter 2 (Overview) provides a brief description of each of the major sections of the LCLS, from the rf photocathode gun, through the experimental stations and electron beam dump. Chapter 3 describes the scientific case for the LCLS. Chapter 4 provides a review of the principles of the FEL physics that the LCLS is based on, and Chapter 5 discusses the choice of the system's physical parameters. Chapters 6 through 10 describe in detail each major element of the system. Chapters 11 through 13 respectively cover undulator controls, mechanical alignment, and radiation issues

  16. A pulsed source neutron reflectometer for surface studies

    International Nuclear Information System (INIS)

    Penfold, J.; Williams, W.G.

    1985-05-01

    A design for a neutron reflectometer for surface studies to be constructed at the SNS is presented. Examples of its use to study problems in surface chemistry, surface magnetism and low dimensional structures are highlighted. (author)

  17. Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy With Bi-Weekly Docetaxel and Carboplatin for Stage III Unresectable, Non-Small-Cell Lung Cancer: Clinical Application of a Protocol Used in a Previous Phase II Study

    Energy Technology Data Exchange (ETDEWEB)

    Saitoh, Jun-Ichi, E-mail: junsaito@sannet.ne.jp [Division of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Saito, Yoshihiro; Kazumoto, Tomoko; Kudo, Shigehiro; Yoshida, Daisaku; Ichikawa, Akihiro [Division of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Sakai, Hiroshi; Kurimoto, Futoshi [Division of Respiratory Disease, Saitama Cancer Center, Saitama (Japan); Kato, Shingo [Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Shibuya, Kei [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma (Japan)

    2012-04-01

    Purpose: To assess the clinical applicability of a protocol evaluated in a previously reported phase II study of concurrent chemoradiotherapy followed by consolidation chemotherapy with bi-weekly docetaxel and carboplatin in patients with stage III, unresectable, non-small-cell lung cancer (NSCLC). Methods and Materials: Between January 2000 and March 2006, 116 previously untreated patients with histologically proven, stage III NSCLC were treated with concurrent chemoradiotherapy. Radiation therapy was administered in 2-Gy daily fractions to a total dose of 60 Gy in combination with docetaxel, 30 mg/m{sup 2}, and carboplatin at an area under the curve value of 3 every 2 weeks during and after radiation therapy. Results: The median survival time for the entire group was 25.5 months. The actuarial 2-year and 5-year overall survival rates were 53% and 31%, respectively. The 3-year cause-specific survival rate was 60% in patients with stage IIIA disease, whereas it was 35% in patients with stage IIIB disease (p = 0.007). The actuarial 2-year and 5-year local control rates were 62% and 55%, respectively. Acute hematologic toxicities of Grade {>=}3 severity were observed in 20.7% of patients, while radiation pneumonitis and esophagitis of Grade {>=}3 severity were observed in 2.6% and 1.7% of patients, respectively. Conclusions: The feasibility of the protocol used in the previous phase II study was reconfirmed in this series, and excellent treatment results were achieved.

  18. Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy With Bi-Weekly Docetaxel and Carboplatin for Stage III Unresectable, Non-Small-Cell Lung Cancer: Clinical Application of a Protocol Used in a Previous Phase II Study

    International Nuclear Information System (INIS)

    Saitoh, Jun-Ichi; Saito, Yoshihiro; Kazumoto, Tomoko; Kudo, Shigehiro; Yoshida, Daisaku; Ichikawa, Akihiro; Sakai, Hiroshi; Kurimoto, Futoshi; Kato, Shingo; Shibuya, Kei

    2012-01-01

    Purpose: To assess the clinical applicability of a protocol evaluated in a previously reported phase II study of concurrent chemoradiotherapy followed by consolidation chemotherapy with bi-weekly docetaxel and carboplatin in patients with stage III, unresectable, non-small-cell lung cancer (NSCLC). Methods and Materials: Between January 2000 and March 2006, 116 previously untreated patients with histologically proven, stage III NSCLC were treated with concurrent chemoradiotherapy. Radiation therapy was administered in 2-Gy daily fractions to a total dose of 60 Gy in combination with docetaxel, 30 mg/m 2 , and carboplatin at an area under the curve value of 3 every 2 weeks during and after radiation therapy. Results: The median survival time for the entire group was 25.5 months. The actuarial 2-year and 5-year overall survival rates were 53% and 31%, respectively. The 3-year cause-specific survival rate was 60% in patients with stage IIIA disease, whereas it was 35% in patients with stage IIIB disease (p = 0.007). The actuarial 2-year and 5-year local control rates were 62% and 55%, respectively. Acute hematologic toxicities of Grade ≥3 severity were observed in 20.7% of patients, while radiation pneumonitis and esophagitis of Grade ≥3 severity were observed in 2.6% and 1.7% of patients, respectively. Conclusions: The feasibility of the protocol used in the previous phase II study was reconfirmed in this series, and excellent treatment results were achieved.

  19. Subsequent childbirth after a previous traumatic birth.

    Science.gov (United States)

    Beck, Cheryl Tatano; Watson, Sue

    2010-01-01

    Nine percent of new mothers in the United States who participated in the Listening to Mothers II Postpartum Survey screened positive for meeting the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for posttraumatic stress disorder after childbirth. Women who have had a traumatic birth experience report fewer subsequent children and a longer length of time before their second baby. Childbirth-related posttraumatic stress disorder impacts couples' physical relationship, communication, conflict, emotions, and bonding with their children. The purpose of this study was to describe the meaning of women's experiences of a subsequent childbirth after a previous traumatic birth. Phenomenology was the research design used. An international sample of 35 women participated in this Internet study. Women were asked, "Please describe in as much detail as you can remember your subsequent pregnancy, labor, and delivery following your previous traumatic birth." Colaizzi's phenomenological data analysis approach was used to analyze the stories of the 35 women. Data analysis yielded four themes: (a) riding the turbulent wave of panic during pregnancy; (b) strategizing: attempts to reclaim their body and complete the journey to motherhood; (c) bringing reverence to the birthing process and empowering women; and (d) still elusive: the longed-for healing birth experience. Subsequent childbirth after a previous birth trauma has the potential to either heal or retraumatize women. During pregnancy, women need permission and encouragement to grieve their prior traumatic births to help remove the burden of their invisible pain.

  20. Research Sources and Microforms in Black Studies: An Annotated Bibliography.

    Science.gov (United States)

    Ridinger, Robert B. Marks

    1985-01-01

    Analyzes 93 reference works and 23 microform collections concerning the Black American experience in 13 subject areas of the social sciences (anthropology, biography, race relations and civil rights, the Black church, communication studies, economics, education, dance, genealogy, Black history, sports, women's studies, and literature and language)…

  1. A compact hard X-ray source for medical imaging and biomolecular studies

    International Nuclear Information System (INIS)

    Cline, D.B.; Green, M.A.; Kolonko, J.

    1995-01-01

    There are a large number of synchrotron light sources in the world. However, these sources are designed for physics, chemistry, and engineering studies. To our knowledge, none have been optimized for either medical imaging or biomolecular studies. There are special needs for these applications. We present here a preliminary design of a very compact source, small enough for a hospital or a biomolecular laboratory, that is suitable for these applications. (orig.)

  2. Fusing Open Source Intelligence and Handheld Situational Awareness - Benghazi Case Study

    Science.gov (United States)

    2014-10-01

    1 DM-0001694 Fusing Open Source Intelligence and Handheld Situational Awareness Benghazi Case Study Jeff Boleng, PhD Marc Novakouski Gene...command and control element at the CIA compound that would have been monitoring OSINT and other sources of intelligence before the attack and... Source Intelligence and Handheld Situational Awareness - Benghazi Case Study 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  3. Integrated source and channel encoded digital communication system design study

    Science.gov (United States)

    Alem, W. K.; Huth, G. K.; Simon, M. K.

    1978-01-01

    The particular Ku-band carrier, PN despreading, and symbol synchronization strategies, which were selected for implementation in the Ku-band transponder aboard the orbiter, were assessed and evaluated from a systems performance viewpoint, verifying that system specifications were met. A study was performed of the design and implementation of tracking techniques which are suitable for incorporation into the Orbiter Ku-band communication system. Emphasis was placed on maximizing tracking accuracy and communication system flexibility while minimizing cost, weight, and system complexity of Orbiter and ground systems hardware. The payload communication study assessed the design and performance of the forward link and return link bent-pipe relay modes for attached and detached payloads. As part of this study, a design for a forward link bent-pipe was proposed which employs a residual carrier but which is tracked by the existing Costas loop.

  4. Studies on characteristics of water sources around Kaiga project area

    International Nuclear Information System (INIS)

    Prakash, T.R.; Krishna Bhat, D.; Thimme Gowda, B.; Sherigara, B.S.; Abdul Khadar, A.M.

    1995-01-01

    A systematic and detailed study of characteristics of ground water, Kali river water and rain water samples around Kaiga project area has been undertaken. The analysis of a large number of parameters revealed that the ground waters and Kali river water are of calcium-bicarbonate type as indicated by Romani's modified Hill Piper diagram. The ionic impurities in ground waters and Kali river water are well within the Indian Drinking Water Specifications. The results obtained would serve as base line data for future impact studies. (author). 6 refs., 1 tab

  5. T Plant source aggregate area management study report

    International Nuclear Information System (INIS)

    1992-11-01

    The US Department of Energy (DOE) Hanford Site in Washington State is organized into numerically designated operational areas including the 100, 200, 300, 400, 600, and 1100 Areas. The US Environmental Protection Agency (EPA), in November 1989, included the 200 Areas of the Hanford Site on the National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) of 1980. Inclusion on the NPL initiates the Remedial Investigation (RI) and Feasibility Study (FS) process for characterizing the nature and extent of contamination, assessing risks to human health and the environment, and selection of remedial actions. This report presents the results of an aggregate area management study (AAMS) for the T Plant Aggregate Area located in the 200 Areas. The study provides the basis for initiating RI/FS under CERCLA or under the Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS). This report also integrates RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past-practice investigations

  6. Z Plant source aggregate area management study report

    International Nuclear Information System (INIS)

    1992-10-01

    The US Department of Energy (DOE) Hanford Site in Washington State is or into numerically designated operational areas including the 100, 200, 300, 400, 600, and 1100 Areas. The US Environmental Protection Agency (EPA), in November 1989, included the 200 Areas of the Hanford Site on the National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) of 1980. Inclusion on the NPL initiates the Remedial Investigation (RI) and Feasibility Study (FS) process for characterizing the nature and extent of contamination, assessing risks to human health and the environment, and selection of remedial actions. This report presents the insults of an aggregate area management study (AAMS) for the Z Plant Aggregate Area located m the 200 Areas. The study provides the basis for initiating RIIFS under CERCLA or under the Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS). This report also integrates RCRA treatment, storage, or disposed (TSD) closure activities with CERCLA and RCRA past-practice investigations

  7. U Plant source aggregate area management study report

    International Nuclear Information System (INIS)

    1992-09-01

    The US Department of Energy (DOE) Hanford Site in Washington State is organized into numerically designated operational areas including the 100, 200, 300, 400, 600, and 1100 Areas. The US Environmental Protection Agency (EPA), in November 1989, included the 200 Areas of the Hanford Site on the National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) of 1980. Inclusion on the NPL initiates the Remedial Investigation (RI) and Feasibility Study (FS) process for characterizing the nature and extent of contamination, assessing risks to human health and the environment, and selection of remedial actions. This report presents the results of an aggregate area management study (AAMS) for the U Plant Aggregate Area located in the 200 Areas. The study provides the basis for initiating RI/FS under CERCLA or under the Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS). This report also integrates RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past-practice investigations

  8. B Plant source aggregate area management study report

    International Nuclear Information System (INIS)

    1993-03-01

    The US Department of Energy (DOE) Hanford Site in Washington state is organized into numerically designated operational areas including the 100, 200, 300, 400, 600, and 100 Areas (Figure 1--1). The US Environmental Protection Agency (EPA), in November 1989, included the 200 Areas of the Hanford KLSite on the National Priorities List (NPL), included the 200 Areas of the Hanford Site on the National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation and Liability Act of Feasibility Study (FS) process for characterizing the nature and extent of contamination, assessing risks to human health and the environment, and selection of remedial actions. This report presents the results of an aggregate area management study (AIMS) for the B Plant Aggregate Area located in the 200 Areas. The study provides the basis for initiating RI/FS under CERCLA or under the Resource which contain reactor fuel processing and waste management Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS). This report also integrates RCRA treatment, storage or disposal (TSD) closure activities with CERCLA and RCRA past-practice investigations

  9. SOURCES OF PROFESSIONALISM, A STUDY OF HIGH SCHOOL TEACHERS.

    Science.gov (United States)

    COLOMBOTOS, JOHN L.

    AN INVESTIGATION WAS CONDUCTED OF THE DISTINCTIVE CHARACTERISTICS OF HIGH SCHOOL TEACHERS AS CONTRASTED WITH THEIR PEERS IN A BUSINESS ORGANIZATION. THE EFFECT OF THIS DISTINCTIVENESS ON THE PERSONAL NATURE OF TENSIONS AND CONFLICTS ASSOCIATED WITH JOB PERFORMANCE, CAREER GOALS, AND CAREER PATTERNS WAS ALSO STUDIED. ITS GENERAL OBJECTIVE WAS TO…

  10. Childhood vesicoureteral reflux studies: registries and repositories sources and nosology.

    Science.gov (United States)

    Chesney, Russell W; Patters, Andrea B

    2013-12-01

    Despite several recent studies, the advisability of antimicrobial prophylaxis and certain imaging studies for urinary tract infections (UTIs) remains controversial. The role of vesicoureteral reflux (VUR) on the severity and re-infection rates for UTIs is also difficult to assess. Registries and repositories of data and biomaterials from clinical studies in children with VUR are valuable. Disease registries are collections of secondary data related to patients with a specific diagnosis, condition or procedure. Registries differ from indices in that they contain more extensive data. A research repository is an entity that receives, stores, processes and/or disseminates specimens (or other materials) as needed. It encompasses the physical location as well as the full range of activities associated with its operation. It may also be referred to as a biorepository. This report provides information about some current registries and repositories that include data and samples from children with VUR. It also describes the heterogeneous nature of the subjects, as some registries and repositories include only data or samples from patients with primary reflux while others also include those from patients with syndromic or secondary reflux. Copyright © 2012 Journal of Pediatric Urology Company. All rights reserved.

  11. Experimental study on a cold neutron source of solid methylbenzene

    Energy Technology Data Exchange (ETDEWEB)

    Utsuro, M; Sugimoto, M; Fujita, Y [Kyoto Univ., Kumatori, Osaka (Japan). Research Reactor Inst.

    1975-10-01

    An experimental study to produce cold neutrons with low temperature solid mesitylene as cold moderator in liquid helium and liquid nitrogen cryostats is reported. Measured cold neutron spectra by using an electron linac and time-of-flight method shows that this material is a better cold moderator than light water ice, giving the cold neutron output not so much inferior to that of solid methane in the temperature range above about 20 K and in the neutron energy region above about 1 MeV.

  12. A Study on Mono-energetic Beam Source Using Characteristic X-ray for Substance Identification System

    International Nuclear Information System (INIS)

    Lee, Hwan Soo

    2009-02-01

    A new mono-energetic beam source was developed by using characteristic X-ray for improving performance of the substance identification system. Most of inspection systems use X-ray tubes for their source modules. However, the broad energy spectrum of X-ray tube causes an increase of uncertainty. In this study, it was found that mono-energetic beam sources can be generated by using X-ray tube and the designed target filter assembly. In order to investigate the monoenergetic beam source, the sensitivity study was conducted with a series of different X-ray tube potentials, radiator and filter materials using Monte Carlo simulation. The developed beam sources have a mono-energy peak at 69 keV, 78 keV and 99 keV, and they are named as characteristic X-ray beam BEAM69, BEAM78 and BEAM99, respectively. The characteristic X-ray beam intensity was over thirty three times more than that of hardening beam used previous work at Hanyang University. And BEAM69 and BEAM99 were applied to the substance identification system as a source. The relative error between results of characteristic X-ray beams and 69 keV and 99 keV photons was about 2% on the average for five unknown materials. In comparison with experiment results by using hardening beam, characteristic X-ray beam achieves better accuracy which is about 6.46 % on the average. Hence, it is expected that the developed characteristic X-ray beam source helps lower uncertainty of the inspection system, and the inspection time will be reduced considerably due to its high beam intensity

  13. Monochromator on a synchrotron undulator source for liquid surface studies

    DEFF Research Database (Denmark)

    Als-Nielsen, Jens Aage; Freund, A.K.

    1992-01-01

    For liquid surface studies a monochromatic beam of relative bandwidth between 0.1% and 1% at a variable angle in the vertical plane between 0-degrees and 10-degrees is needed. The beam should be like a sheet some tens of mu-m thick and some mm wide, and as intense as possible. We discuss a monoch......For liquid surface studies a monochromatic beam of relative bandwidth between 0.1% and 1% at a variable angle in the vertical plane between 0-degrees and 10-degrees is needed. The beam should be like a sheet some tens of mu-m thick and some mm wide, and as intense as possible. We discuss......% of the useful x rays, in full agreement with diffraction theory including secondary extinction. Heat load experiments reported elsewhere in this conference prove that Be crystals can withstand high beam power density and that the thermal deformation is small compared to the mosaic spread. The results...... of the flux calculations are most encouraging: a gain of order 10(3) to 10(4) can be expected as compared to existing liquid surface spectrometers....

  14. To study the municipal solid waste as an energy source

    International Nuclear Information System (INIS)

    Ahmed, Z.; Khan, M.M.

    2005-01-01

    The solid waste management is a very complicated specially when it must be environmental friendly. In the present life, power energy is being more expensive than ever before and human off spring is struggling td acquire cheap ways of getting energy. At the same time, he is facing another problem of waste disposal pollution in the environment, which is a by-product of his industries and population, and when it would be hazardous to life, it will be a more serious problem. In this study, an idea is made to use garbage as an alternate fuel and the analysis of ingredients is done to compare it with the usual fuel i.e. coal. On the other hand, municipal waste (garbage) disposal will be automatically solved. (author)

  15. Interplanetary sources of magnetic storms: A statistical study

    DEFF Research Database (Denmark)

    Vennerstrøm, Susanne

    2001-01-01

    Magnetic storms are mainly caused by the occurrence of intense southward magnetic fields in the interplanetary medium. These fields can be formed directly either by ejection of magnetic structures from the Sun or by stream interaction processes during solar wind propagation. In the present study we...... examine 30 years of satellite measurement of the solar wind during magnetic storms, with the aim of estimating the relative importance of these two processes. We use the solar wind proton temperature relative to the temperature expected from the empirical relation to the solar wind speed T......-p/T-exp, together with the speed gradient, and the interplanetary magnetic field azimuth in the ecliptic, in order to distinguish between the two processes statistically. We find that compression due to stream interaction is at least as important as the direct effect of ejection of intense fields, and probably more...

  16. Interplanetary sources to magnetic storms - A statistical study

    DEFF Research Database (Denmark)

    Vennerstrøm, Susanne

    2001-01-01

    Magnetic storms are mainly caused by the occurrence of intense southward magnetic fields in the interplanetary medium. These fields can be formed directly either by ejection of magnetic structures from the Sun or by stream interaction processes during solar wind propagation. In the present study we...... examine 30 years of satellite measurement of the solar wind during magnetic storms, with the aim of estimating the relative importance of these two processes. We use the solar wind proton temperature relative to the temperature expected from the empirical relation to the solar wind speed Tp/Texp, together...... with the speed gradient, and the interplanetary magnetic field azimuth in the ecliptic, in order to distinguish between the two processes statistically. We find that compression due to stream interaction is at least as important as the direct effect of ejection of intense fields, and probably more so. Only...

  17. Does local endometrial injury in the nontransfer cycle improve the IVF-ET outcome in the subsequent cycle in patients with previous unsuccessful IVF? A randomized controlled pilot study

    Directory of Open Access Journals (Sweden)

    Sachin A Narvekar

    2010-01-01

    Full Text Available Background: Management of repeated implantation failure despite transfer of good-quality embryos still remains a dilemma for ART specialists. Scrapping of endometrium in the nontransfer cycle has been shown to improve the pregnancy rate in the subsequent IVF/ET cycle in recent studies. Aim: The objective of this randomized controlled trial (RCT was to determine whether endometrial injury caused by Pipelle sampling in the nontransfer cycle could improve the probability of pregnancy in the subsequent IVF cycle in patients who had previous failed IVF outcome. Setting: Tertiary assisted conception center. Design: Randomized controlled study. Materials and Methods: 100 eligible patients with previous failed IVF despite transfer of good-quality embryos were randomly allocated to the intervention group and control groups. In the intervention group, Pipelle endometrial sampling was done twice: One in the follicular phase and again in the luteal phase in the cycle preceding the embryo transfer cycle. Outcome Measure: The primary outcome measure was live birth rate. The secondary outcome measures were implantation and clinical pregnancy rates. Results: The live birth rate was significantly higher in the intervention group compared to control group (22.4% and 9.8% P = 0.04. The clinical pregnancy rate in the intervention group was 32.7%, while that in the control group was 13.7%, which was also statistically significant ( P = 0.01. The implantation rate was significantly higher in the intervention group as compared to controls (13.07% vs 7.1% P = 0.04. Conclusions: Endometrial injury in nontransfer cycle improves the live birth rate,clinical pregnancy and implantation rates in the subsequent IVF-ET cycle in patients with previous unsuccessful IVF cycles.

  18. The Efficacy and Safety of Icotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Chemotherapy: A Single-Arm, Multi-Center, Prospective Study.

    Directory of Open Access Journals (Sweden)

    Xingsheng Hu

    Full Text Available Icotinib is a small molecule targeting epidermal growth factor receptor tyrosine kinase, which shows non-inferior efficacy and better safety comparing to gefitinib in previous phase III trial. The present study was designed to further evaluate the efficacy and safety of icotinib in patients with advanced non-small-cell lung cancer (NSCLC previously treated with platinum-based chemotherapy.Patients with NSCLC progressing after one or two lines of chemotherapy were enrolled to receive oral icotinib (125 mg tablet, three times per day. The primary endpoint was progression-free survival. The secondary endpoints included overall survival, objective response rate, time to progression, quality of life and safety.From March 16, 2010 to October 9, 2011, 128 patients from 15 centers nationwide were enrolled, in which 124 patients were available for efficacy evaluation and 127 patients were evaluable for safety. The median progression-free survival and time to progression were 5.0 months (95%CI 2.9-6.6 m and 5.4 months (95%CI 3.1-7.9 m, respectively. The objective response rate and disease control rate were 25.8% and 67.7% respectively. Median overall survival exceeded 17.6 months (95%CI 14.2 m-NA according to censored data. Further follow-up of overall survival is ongoing. The most frequent treatment-related adverse events were rash (26%, 33/127, diarrhea (12.6%, 16/127 and elevation of transaminase (15.7%, 20/127.In general, this study showed similar efficacy and numerically better safety when compared with that in ICOGEN trial, further confirming the efficacy and safety of icotinib in treating patients with advanced NSCLC previously treated with chemotherapy.ClinicalTrials.gov NCT02486354.

  19. The Efficacy and Safety of Icotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Chemotherapy: A Single-Arm, Multi-Center, Prospective Study.

    Science.gov (United States)

    Hu, Xingsheng; Zhang, Li; Shi, Yuankai; Zhou, Caicun; Liu, Xiaoqing; Wang, Dong; Song, Yong; Li, Qiang; Feng, Jifeng; Qin, Shukui; Xv, Nong; Zhou, Jianying; Zhang, Li; Hu, Chunhong; Zhang, Shucai; Luo, Rongcheng; Wang, Jie; Tan, Fenlai; Wang, Yinxiang; Ding, Lieming; Sun, Yan

    2015-01-01

    Icotinib is a small molecule targeting epidermal growth factor receptor tyrosine kinase, which shows non-inferior efficacy and better safety comparing to gefitinib in previous phase III trial. The present study was designed to further evaluate the efficacy and safety of icotinib in patients with advanced non-small-cell lung cancer (NSCLC) previously treated with platinum-based chemotherapy. Patients with NSCLC progressing after one or two lines of chemotherapy were enrolled to receive oral icotinib (125 mg tablet, three times per day). The primary endpoint was progression-free survival. The secondary endpoints included overall survival, objective response rate, time to progression, quality of life and safety. From March 16, 2010 to October 9, 2011, 128 patients from 15 centers nationwide were enrolled, in which 124 patients were available for efficacy evaluation and 127 patients were evaluable for safety. The median progression-free survival and time to progression were 5.0 months (95%CI 2.9-6.6 m) and 5.4 months (95%CI 3.1-7.9 m), respectively. The objective response rate and disease control rate were 25.8% and 67.7% respectively. Median overall survival exceeded 17.6 months (95%CI 14.2 m-NA) according to censored data. Further follow-up of overall survival is ongoing. The most frequent treatment-related adverse events were rash (26%, 33/127), diarrhea (12.6%, 16/127) and elevation of transaminase (15.7%, 20/127). In general, this study showed similar efficacy and numerically better safety when compared with that in ICOGEN trial, further confirming the efficacy and safety of icotinib in treating patients with advanced NSCLC previously treated with chemotherapy. ClinicalTrials.gov NCT02486354.

  20. Conceptual source design and dosimetric feasibility study for intravascular treatment: a proposal for intensity modulated brachytherapy

    International Nuclear Information System (INIS)

    Kim, Si Yong; Han, Eun Young; Palta, Jatinder R.; Ha, Sung W.

    2003-01-01

    To propose a conceptual design of a novel source for intensity modulated brachytherapy. The source design incorporates both radioactive and shielding materials (stainless steel or tungsten), to provide an asymmetric dose intensity in the azimuthal direction. The intensity modulated intravascular brachytherapy was performed by combining a series of dwell positions and times, distributed along the azimuthal coordinates. Two simple designs for the beta-emitting sources, with similar physical dimensions to a 90 Sr/Y Novoste Beat-Cath source, were considered in the dosimetric feasibility study. In the first design, the radioactive and materials each occupy half of the cylinder and in the second, the radioactive material occupies only a quarter of the cylinder. The radial and azimuthal dose distributions around each source were calculated using the MCNP Monte Carlo code. The preliminary hypothetical simulation and optimization results demonstrated the 87% difference between the maximum and minimum doses to the lumen wall, due to off-centering of the radiation source, could be reduced to less than 7% by optimizing the azimuthal dwell positions and times of the partially shielded intravascular brachytherapy sources. The novel brachytherapy source design, and conceptual source delivery system, proposed in this study show promising dosimetric characteristics for the realization of intensity modulated brachytherapy in intravascular treatment. Further development of this concept will center on building a delivery system that can precisely control the angular motion of a radiation source in a small-diameter catheter

  1. Conceptual source design and dosimetric feasibility study for intravascular treatment: a proposal for intensity modulated brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Si Yong; Han, Eun Young; Palta, Jatinder R. [College of Medicine, Florida Univ., Florida (United States); Ha, Sung W. [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    2003-06-01

    To propose a conceptual design of a novel source for intensity modulated brachytherapy. The source design incorporates both radioactive and shielding materials (stainless steel or tungsten), to provide an asymmetric dose intensity in the azimuthal direction. The intensity modulated intravascular brachytherapy was performed by combining a series of dwell positions and times, distributed along the azimuthal coordinates. Two simple designs for the beta-emitting sources, with similar physical dimensions to a {sub 90}Sr/Y Novoste Beat-Cath source, were considered in the dosimetric feasibility study. In the first design, the radioactive and materials each occupy half of the cylinder and in the second, the radioactive material occupies only a quarter of the cylinder. The radial and azimuthal dose distributions around each source were calculated using the MCNP Monte Carlo code. The preliminary hypothetical simulation and optimization results demonstrated the 87% difference between the maximum and minimum doses to the lumen wall, due to off-centering of the radiation source, could be reduced to less than 7% by optimizing the azimuthal dwell positions and times of the partially shielded intravascular brachytherapy sources. The novel brachytherapy source design, and conceptual source delivery system, proposed in this study show promising dosimetric characteristics for the realization of intensity modulated brachytherapy in intravascular treatment. Further development of this concept will center on building a delivery system that can precisely control the angular motion of a radiation source in a small-diameter catheter.

  2. Preliminary study of airborne electromagnetic survey using grounded source; Chihyo source gata kuchu denji tansa no kisoteki kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Mogi, T [Kyushu University, Fukuoka (Japan). Faculty of Engineering; Shimoizumi, M [Kitakyushu Polytechnic College, Kitakyushu (Japan); Kusunoki, K [Central Research Institute of Electric Power Industry, Tokyo (Japan); Morikawa, T [Dowa Engineering Co. Ltd., Okayama (Japan); Jomori, N [Chiba Electronics Research Institute, Chiba (Japan)

    1996-05-01

    For the development of an airborne electromagnetic prospecting method capable of deeper exploration, a basic study was made about a system wherein a transmitter (source) is positioned on the ground and the receiving is done in the sky. Even in case of this airborne electromagnetic method, the TDEM method is supposedly advantageous over others as in case of groundborne exploration. In the study, the transient response of an airborne vertical magnetic field to a horizontal layered structure was calculated. The current source was 2000m long with a capacity of 30A. The one-layer structure was a 10 Ohm m semi-infinite ground, and the two-layer structure had a 100 Ohm m structure just under the one-layer structure. The result of the calculation suggests that, in the absence of a layer of extremely low resistivity, observation of an approximately 1 second long transient response aboard a helicopter flying at approximately 50km/h will enable an approximately 1000m deep exploration. Problems to affect airborne observation, such as swinging, natural magnetic field fluctuation, and artificially produced noises were investigated by use of a magnetometer suspended from a helicopter in flight. 2 refs., 6 figs.

  3. RIO EPICS device support application case study on an ion source control system (ISHP)

    Energy Technology Data Exchange (ETDEWEB)

    Sanz, Diego [UPM – Universidad Politécnica de Madrid, Madrid (Spain); Ruiz, Mariano, E-mail: mariano.ruiz@upm.es [UPM – Universidad Politécnica de Madrid, Madrid (Spain); Eguiraun, Mikel [Department of Electricity and Electronic, Faculty of Science and Technology, University of Basque Country, Bilbao (Spain); Arredondo, Iñigo [ESS Bilbao Consortium, Zamudio (Spain); Badillo, Inari; Jugo, Josu [Department of Electricity and Electronic, Faculty of Science and Technology, University of Basque Country, Bilbao (Spain); Vega, Jesús; Castro, Rodrigo [Asociación EURATOM/CIEMAT, Madrid (Spain)

    2015-10-15

    Highlights: • A use case example of RIO/FlexRIO design methodology is described. • Ion source device is controlled and monitored by means EPICS IOCs. • NIRIO EPICS device support demonstrates that is able to manage RIO devices. • Easy and fast deployment is possible using RIO/FlexRIO design methodology using NIRIO-EDS. • RIO/FlexRIO technology and EPICS are a good combination for support large scale experiments in fusion environments. - Abstract: Experimental Physics and Industrial Control System (EPICS) is a software tool that during last years has become relevant as a main framework to deploy distributed control systems in large scientific environments. At the moment, ESS Bilbao uses this middleware to perform the control of their Ion Source Hydrogen Positive (ISHP) project. The implementation of the control system was based on: PXI Real Time controllers using the LabVIEW-RT and LabVIEW-EPICS tools; and RIO devices based on Field-Programmable Gate Array (FPGA) technology. Intended to provide a full compliant EPICS IOCs for RIO devices and to avoid additional efforts on the system maintainability, a migration of the current system to a derivative Red Hat Linux (CentOS) environment has been conducted. This paper presents a real application case study for using the NIRIO EPICS device support (NIRIO-EDS) to give support to the ISHP. Although RIO FPGA configurations are particular solutions for ISHP performance, the NIRIO-EDS has permitted the control and monitoring of devices by applying a well-defined design methodology into the previous FPGA configuration for RIO/FlexRIO devices. This methodology has permitted a fast and easy deployment for the new robust, scalable and maintainable software to support RIO devices into the ISHP control architecture.

  4. Optimization study of normal conductor tokamak for commercial neutron source

    Science.gov (United States)

    Fujita, T.; Sakai, R.; Okamoto, A.

    2017-05-01

    The optimum conceptual design of tokamak with normal conductor coils was studied for minimizing the cost for producing a given neutron flux by using a system code, PEC. It is assumed that the fusion neutrons are used for burning transuranics from the fission reactor spent fuel in the blanket and a fraction of the generated electric power is circulated to opearate the tokamak with moderate plasma fusion gain. The plasma performance was assumed to be moderate ones; {β\\text{N}}~∼ ~3{--}4 in the aspect ratio A~=~2{--}3 and {{H}98y2}~=~1 . The circulating power is an important factor affecting the cost. Though decreasing the aspect ratio is useful to raise the plasma beta and decrease the toroidal field, the maximum field in the coil starts to rise in the very low aspect ratio range and then the circulating power increases with decrease in the plasma aspect ratio A below A~∼ ~2 , while the construction cost increases with A . As a result, the cost per neutron has its minimum around A~∼ ~2.2 , namely, between ST and the conventional tokamak. The average circulating power fraction is expected to be ~51%.

  5. Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.

    Science.gov (United States)

    Unfer, Vittorio; Raffone, Emanuela; Rizzo, Piero; Buffo, Silvia

    2011-11-01

    Several factors can affect oocyte quality and therefore pregnancy outcome in assisted reproductive technology (ART) cycles. Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin). In the present study, we aim to evaluate the pregnancy outcomes after the administration of myo-inositol combined with melatonin in women who failed to conceive in previous in vitro fertilization (IVF) cycles due to poor oocyte quality. Forty-six women were treated with 4 g/day myo-inositol and 3 mg/day melatonin (inofolic® and inofolic® Plus, Lo.Lipharma, Rome) for 3 months and then underwent a new IVF cycle. After treatment, the number of mature oocytes, the fertilization rate, the number of both, total and top-quality embryos transferred were statistically higher compared to the previous IVF cycle, while there was no difference in the number of retrieved oocyte. After treatment, a total of 13 pregnancies occurred, 9 of them were confirmed echographically; four evolved in spontaneous abortion. The treatment with myo-inositol and melatonin improves ovarian stimulation protocols and pregnancy outcomes in infertile women with poor oocyte quality.

  6. Studies of the contributions of nonpoint terrestrial sources to mineral water quality

    International Nuclear Information System (INIS)

    Huff, D.D.

    1977-05-01

    The contributions of nonpoint sources of water quality constituents represent a background loading rate that will not be reduced easily. Consequently, those contributions may have a dominant effect on aquatic ecosystems once point sources have been controlled. Modeling studies conducted at the Tennessee Valley Authority and Oak Ridge National Laboratory represent contrasting approaches that highlight some of the possibilities for predicting nonpoint source inputs to aquatic systems

  7. New complete sample of identified radio sources. Part 2. Statistical study

    International Nuclear Information System (INIS)

    Soltan, A.

    1978-01-01

    Complete sample of radio sources with known redshifts selected in Paper I is studied. Source counts in the sample and the luminosity - volume test show that both quasars and galaxies are subject to the evolution. Luminosity functions for different ranges of redshifts are obtained. Due to many uncertainties only simplified models of the evolution are tested. Exponential decline of the liminosity with time of all the bright sources is in a good agreement both with the luminosity- volume test and N(S) realtion in the entire range of observed flux densities. It is shown that sources in the sample are randomly distributed in scales greater than about 17 Mpc. (author)

  8. Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study.

    Science.gov (United States)

    Chanan-Khan, Asher; Cramer, Paula; Demirkan, Fatih; Fraser, Graeme; Silva, Rodrigo Santucci; Grosicki, Sebastian; Pristupa, Aleksander; Janssens, Ann; Mayer, Jiri; Bartlett, Nancy L; Dilhuydy, Marie-Sarah; Pylypenko, Halyna; Loscertales, Javier; Avigdor, Abraham; Rule, Simon; Villa, Diego; Samoilova, Olga; Panagiotidis, Panagiots; Goy, Andre; Mato, Anthony; Pavlovsky, Miguel A; Karlsson, Claes; Mahler, Michelle; Salman, Mariya; Sun, Steven; Phelps, Charles; Balasubramanian, Sriram; Howes, Angela; Hallek, Michael

    2016-02-01

    Most patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma relapse after initial therapy. Bendamustine plus rituximab is often used in the relapsed or refractory setting. We assessed the efficacy and safety of adding ibrutinib, an oral covalent inhibitor of Bruton's tyrosine kinase (BTK), to bendamustine plus rituximab in patients with previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma. The HELIOS trial was an international, double-blind, placebo-controlled, phase 3 study in adult patients (≥18 years of age) who had active chronic lymphocytic leukaemia or small lymphocytic lymphoma with measurable lymph node disease (>1·5 cm) by CT scan, and had relapsed or refractory disease following one or more previous lines of systemic therapy consisting of at least two cycles of a chemotherapy-containing regimen, an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, and adequate bone marrow, liver, and kidney function. Patients with del(17p) were excluded because of known poor response to bendamustine plus rituximab. Patients who had received previous treatment with ibrutinib or other BTK inhibitors, refractory disease or relapse within 24 months with a previous bendamustine-containing regimen, or haemopoietic stem-cell transplant were also excluded. Patients were randomly assigned (1:1) by a web-based system to receive bendamustine plus rituximab given in cycles of 4 weeks' duration (bendamustine: 70 mg/m(2) intravenously on days 2-3 in cycle 1, and days 1-2 in cycles 2-6; rituximab: 375 mg/m(2) on day 1 of cycle 1, and 500 mg/m(2) on day 1 of cycles 2-6 for a maximum of six cycles) with either ibrutinib (420 mg daily orally) or placebo until disease progression or unacceptable toxicity. Patients were stratified according to whether they were refractory to purine analogues and by number of previous lines of therapy. The primary endpoint was independent review committee (IRC)-assessed progression

  9. The effect of location of a convective heat source on displacement ventilation: CFD study

    Energy Technology Data Exchange (ETDEWEB)

    Park, H.J.; Holland, D. [Dunham Associates, Inc., Minneapolis, MN (United States). Advanced Technologies Group

    2001-08-01

    Two-dimensional computational simulations are performed to examine the effect of vertical location of a convective heat source on thermal displacement ventilation systems. In this study, a heat source is modeled with seven different heights from the floor (0.5, 0.75, 1.0, 1.25, 1.5, 1.75, 2.0 m) in a displacement ventilation environment. The flow and temperature fields in thermal displacement ventilation systems vary depending on the location of the heat source. As the heat source rises, the convective heat gain from the heat source to an occupied zone becomes less significant. This effect changes the temperature field and results in the reduction of the cooling load in the occupied zone. The stratification level is also affected by the heat source location at a given flow rate. (author)

  10. Characteristics of rotating target neutron source and its use in radiation effects studies

    International Nuclear Information System (INIS)

    Van Konynenburg, R.A.; Barschall, H.H.; Booth, R.; Wong, C.

    1975-07-01

    The Rotating Target Neutron Source (RTNS) at Lawrence Livermore Laboratory is currently the most intense source of DT fusion neutrons available for the study of radiation effects in materials. This paper will present a brief description of the machine, outline the history of its development and discuss its performance characteristics and its application to CTR materials research. (U.S.)

  11. Manufacturing cost study on the ion sources for the Mirror Fusion Test Facility

    International Nuclear Information System (INIS)

    A study of the cost of manufacturing 48 ion sources for the Mirror Fusion Test Facility is described. The estimate is built up from individual part costs and assembly operation times for the 80 kV prototype source constructed by LLL and described by LLL drawings furnished during December 1978. Recommendations for cost reduction are made

  12. Mixed Waste Management Facility (MWMF) Old Burial Ground (OBG) source control technology and inventory study

    Energy Technology Data Exchange (ETDEWEB)

    Flach, G.P.; Rehder, T.E.; Kanzleiter, J.P.

    1996-10-02

    This report has been developed to support information needs for wastes buried in the Burial Ground Complex. Information discussed is presented in a total of four individual attachments. The general focus of this report is to collect information on estimated source inventories, leaching studies, source control technologies, and to provide information on modeling parameters and associated data deficiencies.

  13. Mixed Waste Management Facility (MWMF) Old Burial Ground (OBG) source control technology and inventory study

    International Nuclear Information System (INIS)

    Flach, G.P.; Rehder, T.E.; Kanzleiter, J.P.

    1996-01-01

    This report has been developed to support information needs for wastes buried in the Burial Ground Complex. Information discussed is presented in a total of four individual attachments. The general focus of this report is to collect information on estimated source inventories, leaching studies, source control technologies, and to provide information on modeling parameters and associated data deficiencies

  14. Using the genome aggregation database, computational pathogenicity prediction tools, and patch clamp heterologous expression studies to demote previously published long QT syndrome type 1 mutations from pathogenic to benign.

    Science.gov (United States)

    Clemens, Daniel J; Lentino, Anne R; Kapplinger, Jamie D; Ye, Dan; Zhou, Wei; Tester, David J; Ackerman, Michael J

    2018-04-01

    Mutations in the KCNQ1-encoded Kv7.1 potassium channel cause long QT syndrome (LQTS) type 1 (LQT1). It has been suggested that ∼10%-20% of rare LQTS case-derived variants in the literature may have been published erroneously as LQT1-causative mutations and may be "false positives." The purpose of this study was to determine which previously published KCNQ1 case variants are likely false positives. A list of all published, case-derived KCNQ1 missense variants (MVs) was compiled. The occurrence of each MV within the Genome Aggregation Database (gnomAD) was assessed. Eight in silico tools were used to predict each variant's pathogenicity. Case-derived variants that were either (1) too frequently found in gnomAD or (2) absent in gnomAD but predicted to be pathogenic by ≤2 tools were considered potential false positives. Three of these variants were characterized functionally using whole-cell patch clamp technique. Overall, there were 244 KCNQ1 case-derived MVs. Of these, 29 (12%) were seen in ≥10 individuals in gnomAD and are demotable. However, 157 of 244 MVs (64%) were absent in gnomAD. Of these, 7 (4%) were predicted to be pathogenic by ≤2 tools, 3 of which we characterized functionally. There was no significant difference in current density between heterozygous KCNQ1-F127L, -P477L, or -L619M variant-containing channels compared to KCNQ1-WT. This study offers preliminary evidence for the demotion of 32 (13%) previously published LQT1 MVs. Of these, 29 were demoted because of their frequent sighting in gnomAD. Additionally, in silico analysis and in vitro functional studies have facilitated the demotion of 3 ultra-rare MVs (F127L, P477L, L619M). Copyright © 2017 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  15. Source localization of rhythmic ictal EEG activity: a study of diagnostic accuracy following STARD criteria.

    Science.gov (United States)

    Beniczky, Sándor; Lantz, Göran; Rosenzweig, Ivana; Åkeson, Per; Pedersen, Birthe; Pinborg, Lars H; Ziebell, Morten; Jespersen, Bo; Fuglsang-Frederiksen, Anders

    2013-10-01

    Although precise identification of the seizure-onset zone is an essential element of presurgical evaluation, source localization of ictal electroencephalography (EEG) signals has received little attention. The aim of our study was to estimate the accuracy of source localization of rhythmic ictal EEG activity using a distributed source model. Source localization of rhythmic ictal scalp EEG activity was performed in 42 consecutive cases fulfilling inclusion criteria. The study was designed according to recommendations for studies on diagnostic accuracy (STARD). The initial ictal EEG signals were selected using a standardized method, based on frequency analysis and voltage distribution of the ictal activity. A distributed source model-local autoregressive average (LAURA)-was used for the source localization. Sensitivity, specificity, and measurement of agreement (kappa) were determined based on the reference standard-the consensus conclusion of the multidisciplinary epilepsy surgery team. Predictive values were calculated from the surgical outcome of the operated patients. To estimate the clinical value of the ictal source analysis, we compared the likelihood ratios of concordant and discordant results. Source localization was performed blinded to the clinical data, and before the surgical decision. Reference standard was available for 33 patients. The ictal source localization had a sensitivity of 70% and a specificity of 76%. The mean measurement of agreement (kappa) was 0.61, corresponding to substantial agreement (95% confidence interval (CI) 0.38-0.84). Twenty patients underwent resective surgery. The positive predictive value (PPV) for seizure freedom was 92% and the negative predictive value (NPV) was 43%. The likelihood ratio was nine times higher for the concordant results, as compared with the discordant ones. Source localization of rhythmic ictal activity using a distributed source model (LAURA) for the ictal EEG signals selected with a standardized method

  16. Study and realisation of an ion source obtained by electronic bombardment - experimentation with phosphorus

    International Nuclear Information System (INIS)

    Schneider, Philippe

    1979-01-01

    This research thesis reports the study and development of an ion source by electronic bombardment. In order to solve some practical difficulties (cathode destruction, source instability, and so on), the design of each component has been very careful, notably for the electron gun. The author first briefly discusses the exiting ionisation processes, gives a list of ion which can be produced, with a focus on phosphorus for which the ionisation cross section is defined and assessed. After an assessment of different ionisation processes, and an indication of performance of the best existing sources, the author explains the choice for a totally different process. In the second part, he describes the experimental device, and particularly the electron gun as its design has been an important part of this research work. The source operation is described and its characteristics and performance are studied. Finally, the author outlines that some improvements are still possible to obtain a totally exploitable source [fr

  17. Residents’ Household Solid Waste (HSW Source Separation Activity: A Case Study of Suzhou, China

    Directory of Open Access Journals (Sweden)

    Hua Zhang

    2014-09-01

    Full Text Available Though the Suzhou government has provided household solid waste (HSW source separation since 2000, the program remains largely ineffective. Between January and March 2014, the authors conducted an intercept survey in five different community groups in Suzhou, and 505 valid surveys were completed. Based on the survey, the authors used an ordered probit regression to study residents’ HSW source separation activities for both Suzhou and for the five community groups. Results showed that 43% of the respondents in Suzhou thought they knew how to source separate HSW, and 29% of them have source separated HSW accurately. The results also found that the current HSW source separation pilot program in Suzhou is valid, as HSW source separation facilities and residents’ separation behavior both became better and better along with the program implementation. The main determinants of residents’ HSW source separation behavior are residents’ age, HSW source separation facilities and government preferential policies. The accessibility to waste management service is particularly important. Attitudes and willingness do not have significant impacts on residents’ HSW source separation behavior.

  18. Receptor modeling studies for the characterization of PM10 pollution sources in Belgrade

    Directory of Open Access Journals (Sweden)

    Mijić Zoran

    2012-01-01

    Full Text Available The objective of this study is to determine the major sources and potential source regions of PM10 over Belgrade, Serbia. The PM10 samples were collected from July 2003 to December 2006 in very urban area of Belgrade and concentrations of Al, V, Cr, Mn, Fe, Ni, Cu, Zn, Cd and Pb were analyzed by atomic absorption spectrometry. The analysis of seasonal variations of PM10 mass and some element concentrations reported relatively higher concentrations in winter, what underlined the importance of local emission sources. The Unmix model was used for source apportionment purpose and the four main source profiles (fossil fuel combustion; traffic exhaust/regional transport from industrial centers; traffic related particles/site specific sources and mineral/crustal matter were identified. Among the resolved factors the fossil fuel combustion was the highest contributor (34% followed by traffic/regional industry (26%. Conditional probability function (CPF results identified possible directions of local sources. The potential source contribution function (PSCF and concentration weighted trajectory (CWT receptor models were used to identify spatial source distribution and contribution of regional-scale transported aerosols. [Projekat Ministarstva nauke Republike Srbije, br. III43007 i br. III41011

  19. Post-processing of Monte Carlo simulations for rapid BNCT source optimization studies

    International Nuclear Information System (INIS)

    Bleuel, D.L.; Chu, W.T.; Donahue, R.J.; Ludewigt, B.A.; Vujic, J.

    2000-01-01

    A great advantage of some neutron sources, such as accelerator-produced sources, is that they can be tuned to produce different spectra. Unfortunately, optimization studies are often time-consuming and difficult, as they require a lengthy Monte Carlo simulation for each source. When multiple characteristics, such as energy, angle, and spatial distribution of a neutron beam are allowed to vary, an overwhelming number of simulations may be required. Many optimization studies, therefore, suffer from a small number of datapoints, restrictive treatment conditions, or poor statistics. By scoring pertinent information from every particle tally in a Monte Carlo simulation, then applying appropriate source variable weight factors in a post-processing algorithm, a single simulation can be used to model any number of multiple sources. Through this method, the response to a new source can be modeled in minutes or seconds, rather than hours or days, allowing for the analysis of truly variable source conditions of much greater resolution than is normally possible when a new simulation must be run for each datapoint in a study. This method has been benchmarked and used to recreate optimization studies in a small fraction of the time spent in the original studies

  20. Post-processing of Monte Carlo simulations for rapid BNCT source optimization studies

    International Nuclear Information System (INIS)

    Bleuel, D.L.; Chu, W.T.; Donahue, R.J.; Ludewigt, B.A.; Vujic, J.

    2000-01-01

    A great advantage of some neutron sources, such as accelerator-produced sources, is that they can be tuned to produce different spectra. Unfortunately, optimization studies are often time-consuming and difficult, as they require a lengthy Monte Carlo simulation for each source. When multiple characteristics, such as energy, angle, and spatial distribution of a neutron beam are allowed to vary, an overwhelming number of simulations may be required. Many optimization studies, therefore, suffer from a small number of data points, restrictive treatment conditions, or poor statistics. By scoring pertinent information from every particle tally in a Monte Carlo simulation, then applying appropriate source variable weight factors in a post-processing algorithm; a single simulation can be used to model any number of multiple sources. Through this method, the response to a new source can be modeled in minutes or seconds, rather than hours or days, allowing for the analysis of truly variable source conditions of much greater resolution than is normally possible when a new simulation must be run for each data point in a study. This method has been benchmarked and used to recreate optimization studies in a small fraction of the time spent in the original studies. (author)

  1. Experimental study of self magnetic pinch diode as flash radiography source at 4 megavolt

    International Nuclear Information System (INIS)

    Etchessahar, Bertrand; Bicrel, Béatrice; Cassany, Bruno; Desanlis, Thierry; Voisin, Luc; Maisonny, Rémi; Toury, Martial; Hourdin, Laurent; Cartier, Frédéric; Cartier, Stéphanie; D'Almeida, Thierry; Delbos, Christophe; Garrigues, Alain; Plouhinec, Damien; Ritter, Sandra; Sol, David; Zucchini, Frédéric; Caron, Michel

    2013-01-01

    The Self Magnetic Pinch (SMP) diode is a potential high-brightness X-ray source for high voltage generators (2–10 MV) that has shown good reliability for flash radiography applications [D. D. Hinchelwood et al., “High power self-pinch diode experiments for radiographic applications” IEEE Trans. Plasma Sci. 35(3), 565–572 (2007)]. We have studied this diode at about 4 MV, driven by the ASTERIX generator operated at the CEA/GRAMAT [G. Raboisson et al., “ASTERIX, a high intensity X-ray generator,” in Proceedings of the 7th IEEE Pulsed Power Conference (1989), pp. 567–570]. This generator, made up of a capacitor bank and a Blumlein line, was initially designed to test the behavior of electronic devices under irradiation. In our experiments, the vacuum diode is modified in order to set up flash radiographic diodes. A previous set of radiographic experiments was carried out on ASTERIX with a Negative Polarity Rod Pinch (NPRP) diode [B. Etchessahar et al., “Study and optimization of negative polarity rod pinch diode as flash radiography source at 4.5 MV,” Phys. Plasmas 19(9), 093104 (2012)]. The SMP diode which is examined in the present study provides an alternative operating point on the same generator and a different radiographic performance: 142 ± 11 rad at 1 m dose (Al) for a 3.46 ± 0.42 mm spot size (1.4× FWHM of the LSF). This performance is obtained in a reproducible and robust nominal configuration. However, several parametric variations were also tested, such as cathode diameter and anode/cathode gap. They showed that an even better performance is accessible after optimization, in particular, a smaller spot size (<3 mm). Numbers of electrical, optical, and X-ray diagnostics have been implemented in order to gain more insight in the diode physics and to optimize it further. For the first time in France, visible and laser imaging of the SMP diode has been realized, from a radial point of view, thus, providing key information on the electrode

  2. A study of faint radio sources near the North Galactic Pole

    International Nuclear Information System (INIS)

    Benn, C.R.

    1981-09-01

    A large amount of observational data has been obtained on faint radio sources in a small area of sky near the North Galactic Pole (the 5C 12 area). This provides a new perspective (3 decades in flux density from the 3CR catalogue) on the physical properties and cosmological evolution of extragalactic radio sources. Chapter 1 introduces the problem and concludes that faint-object cosmology is best served by intensive investigation of sources in a small area of sky. An optimum area is chosen, at right ascension 12sup(h) 58sup(m) 43sup(s) and declination 35 0 14' 00'' (1950.0). Chapter 2 describes the 5C12 radio survey (complete to 9mJy apparent flux density at 408MHz) conducted with the One Mile Telescope at Cambridge. Chapter 4 describes a 4.85GHz survey to 20mJy of the area, conducted at Effelsberg. In chapter 5, a program of optical identification for the sources is described, using deep (msub(g) = 22.5, msub(y) = 20.7) Schmidt plates taken at Hale Observatories. A statistical algorithm is developed to cope with the problems of optical confusion due to radio positional errors. Chapter 6 draws on data from the previous 4, and presents results concerning radio source counts, spectral index distributions, optical identifications and clustering. (author)

  3. Design of intense neutron source for fusion material study and the role of universities

    International Nuclear Information System (INIS)

    Ishino, Shiori

    1993-01-01

    Need and requirement for the intense neutron source for fusion materials study have been discussed for many years. Recently, international climate has been becoming gradually maturing to consider this problem more seriously because of the recognition of crucial importance of solving materials problems for fusion energy development. The present symposium was designed to discuss the problems associated with the intense neutron source for material irradiation studies which will have a potential for the National Institute for Fusion Science to become one of the important future research areas. The symposium comprises five sessions; first, the role of materials research in fusion development strategies was discussed followed by a brief summary of current IFMIF (International Fusion Materials Irradiation Facility) activity. Despite the pressing need for intense fusion neutron source, currently available neutron sources are reactor or accelerator based sources of which FFTF and LASREF were discussed. Then, various concepts of intense neutron source candidates were presented including ESNIT, which are currently under design by JAERI. In the fourth session, discussions were made on the study of materials with the intense neutron source from the viewpoint of materials scientists and engineers as the user of the facility. This is followed by discussions on the role of universities from the two stand points, namely, fusion irradiation studies and fusion materials development. Finally summary discussions were made by the participants, indicating important role fundamental studies in universities for the full utilization of irradiation data and the need of pure 14 MeV neutron source for fundamental studies together with the intense surrogate neutron sources. (author)

  4. Sources of Strategic Information in Farm Management in Poland. Study Results

    Directory of Open Access Journals (Sweden)

    Jacek Jaworski

    2017-03-01

    Full Text Available Purposes: The main goal of the paper is to determine the signifcance of selected sources of strategic information, used by Polish farmers in decision making. In addition, an attempt was made to determine the factors impacting the evaluation of those sources among the traits of the farmer and his farm. Methodology: Data was gathered using the questionnaire method and analysed with standard tools of descriptive statistics. Findings: The farmers deemed personalised sources of strategic information the most important, especially agricultural advisers, input suppliers and buyers of agricultural products. From among institutional (non-personalised sources, local government and the chamber of agriculture were signifcant. Business information agencies and survey companies are the least important sources for farmers. The characteristics of the surroundings of the farm – specifcally, its geographic location and the size of settlement where it is located proved to have the widest impact on the evaluation of the sources included in the study. From among the organisational factors, only farm size has a signifcant impact. Research limitations/implications: The study was confned to a representative group of farmers in Poland. A closed list of sources of strategic information was used. Originality/value: The study results contribute to the knowledge on the functioning of Polish agriculture and may also be used in comparative studies, characterising this sector’s diversity within Europe. They can in turn contribute to properly focusing on supporting the policy of balanced agriculture development in the EU.

  5. Light source for synchrotron radiation x-ray topography study at Beijing Synchrotron Radiation Laboratory (BSRL)

    International Nuclear Information System (INIS)

    Zhao Jiyong; Jiang Jianhua; Tian Yulian

    1992-01-01

    Characteristics of the synchrotron radiation source for X-ray topography study at Beijing Synchrotron Radiation Laboratory (BSRL) is described, local geometrical resolution of topographies is discussed, and the diffracting intensities of white beam topography is given

  6. Functional magnetic resonance imaging study of external source memory and its relation to cognitive insight in non-clinical subjects.

    Science.gov (United States)

    Buchy, Lisa; Hawco, Colin; Bodnar, Michael; Izadi, Sarah; Dell'Elce, Jennifer; Messina, Katrina; Lepage, Martin

    2014-09-01

    Previous research has linked cognitive insight (a measure of self-reflectiveness and self-certainty) in psychosis with neurocognitive and neuroanatomical disturbances in the fronto-hippocampal neural network. The authors' goal was to use functional magnetic resonance imaging (fMRI) to investigate the neural correlates of cognitive insight during an external source memory paradigm in non-clinical subjects. At encoding, 24 non-clinical subjects travelled through a virtual city where they came across 20 separate people, each paired with a unique object in a distinct location. fMRI data were then acquired while participants viewed images of the city, and completed source recognition memory judgments of where and with whom objects were seen, which is known to involve prefrontal cortex. Cognitive insight was assessed with the Beck Cognitive Insight Scale. External source memory was associated with neural activity in a widespread network consisting of frontal cortex, including ventrolateral prefrontal cortex (VLPFC), temporal and occipital cortices. Activation in VLPFC correlated with higher self-reflectiveness and activation in midbrain correlated with lower self-certainty during source memory attributions. Neither self-reflectiveness nor self-certainty significantly correlated with source memory accuracy. By means of virtual reality and in the context of an external source memory paradigm, the study identified a preliminary functional neural basis for cognitive insight in the VLPFC in healthy people that accords with our fronto-hippocampal theoretical model as well as recent neuroimaging data in people with psychosis. The results may facilitate the understanding of the role of neural mechanisms in psychotic disorders associated with cognitive insight distortions. © 2014 The Authors. Psychiatry and Clinical Neurosciences © 2014 Japanese Society of Psychiatry and Neurology.

  7. Development of a source-exposure matrix for occupational exposure assessment of electromagnetic fields in the INTEROCC study.

    Science.gov (United States)

    Vila, Javier; Bowman, Joseph D; Figuerola, Jordi; Moriña, David; Kincl, Laurel; Richardson, Lesley; Cardis, Elisabeth

    2017-07-01

    To estimate occupational exposures to electromagnetic fields (EMF) for the INTEROCC study, a database of source-based measurements extracted from published and unpublished literature resources had been previously constructed. The aim of the current work was to summarize these measurements into a source-exposure matrix (SEM), accounting for their quality and relevance. A novel methodology for combining available measurements was developed, based on order statistics and log-normal distribution characteristics. Arithmetic and geometric means, and estimates of variability and maximum exposure were calculated by EMF source, frequency band and dosimetry type. The mean estimates were weighted by our confidence in the pooled measurements. The SEM contains confidence-weighted mean and maximum estimates for 312 EMF exposure sources (from 0 Hz to 300 GHz). Operator position geometric mean electric field levels for radiofrequency (RF) sources ranged between 0.8 V/m (plasma etcher) and 320 V/m (RF sealer), while magnetic fields ranged from 0.02 A/m (speed radar) to 0.6 A/m (microwave heating). For extremely low frequency sources, electric fields ranged between 0.2 V/m (electric forklift) and 11,700 V/m (high-voltage transmission line-hotsticks), whereas magnetic fields ranged between 0.14 μT (visual display terminals) and 17 μT (tungsten inert gas welding). The methodology developed allowed the construction of the first EMF-SEM and may be used to summarize similar exposure data for other physical or chemical agents.

  8. Which surgery should be offered for carpal tunnel syndrome in a patient who was previously treated for recurrence on the contralateral side? Preliminary study of 13 patients with the Canaletto® implant.

    Science.gov (United States)

    Illuminati, I; Seigle-Murandi, F; Gouzou, S; Fabacher, T; Facca, S; Hidalgo Diaz, J J; Liverneaux, P

    2017-12-01

    There are no published studies on the management of carpal tunnel syndrome (CTS) patients who have already been operated for recurrent CTS on the contralateral side. The aim of this study was to evaluate 13 patients with CTS who underwent primary release using a Canaletto ® implant. The 13 patients had all been operated for recurrent CTS previously. On the contralateral side, they all had subjective signs, and two of them already had complications. All were operated with the Canaletto ® implant according to Duché's technique, in a mean of 20minutes. After a mean 19.3-month follow-up, paresthesia, pain, and QuickDASH scores were significantly improved, even in one patient who underwent revision at another facility. This preliminary study suggests that use of a Canaletto ® implant as first-line treatment for CTS in patients who already underwent revision surgery on the other side is a simple and safe technique, without worsening of symptoms. These findings should be assessed with a prospective randomized controlled trial. Copyright © 2017 SFCM. Published by Elsevier Masson SAS. All rights reserved.

  9. Determination of Key Risk Supervision Areas around River-Type Water Sources Affected by Multiple Risk Sources: A Case Study of Water Sources along the Yangtze’s Nanjing Section

    Directory of Open Access Journals (Sweden)

    Qi Zhou

    2017-02-01

    Full Text Available To provide a reference for risk management of water sources, this study screens the key risk supervision areas around river-type water sources (hereinafter referred to as the water sources threatened by multiple fixed risk sources (the risk sources, and establishes a comprehensive methodological system. Specifically, it comprises: (1 method of partitioning risk source concentrated sub-regions for screening water source perimeter key risk supervision areas; (2 approach of determining sub-regional risk indexes (SrRI, which characterizes the scale of sub-regional risks considering factors like risk distribution intensity within sub-regions, risk indexes of risk sources (RIRS, characterizing the risk scale of risk sources and the number of risk sources; and (3 method of calculating sub-region’s risk threats to the water sources (SrTWS which considers the positional relationship between water sources and sub-regions as well as SrRI, and the criteria for determining key supervision sub-regions. Favorable effects are achieved by applying this methodological system in determining water source perimeter sub-regions distributed along the Yangtze’s Nanjing section. Results revealed that for water sources, the key sub-regions needing supervision were SD16, SD06, SD21, SD26, SD15, SD03, SD02, SD32, SD10, SD11, SD14, SD05, SD27, etc., in the order of criticality. The sub-region with the greatest risk threats on the water sources was SD16, which was located in the middle reaches of Yangtze River. In general, sub-regions along the upper Yangtze reaches had greater threats to water sources than the lower reach sub-regions other than SD26 and SD21. Upstream water sources were less subject to the threats of sub-regions than the downstream sources other than NJ09B and NJ03.

  10. Apportionment of sources affecting water quality: Case study of Kandla Creek, Gulf of Katchchh

    Digital Repository Service at National Institute of Oceanography (India)

    Dalal, S.G.; Shirodkar, P.V.; Verlekar, X.N.; Jagtap, T.G.; Rao, G.S.

    status of the environment. Several multivariate models are used for source apportionment studies, as they pinpoint the possible factors or sources that influence the water quality (Morales et al., 1999; Wunderlin et al., 2001; Petersen et al., 2001... and statistical approaches. Ecology 74: 2201– 2214. Morales, M. M., Martih, P., Llopis, A., Campos, L., and Sagrado, J. 1999. An environmental study by factor analysis of surface seawater in the Gulf of Valencia (western Mediterranean). Analytica Chimica Acta 394...

  11. Overview of recent studies and design changes for the FNAL magnetron ion source

    Science.gov (United States)

    Bollinger, D. S.; Sosa, A.

    2017-08-01

    This paper presents several studies and design changes that will eventually be implemented to the Fermi National Accelerator Laboratory (FNAL) magnetron ion source. The topics include tungsten cathode insert, solenoid gas valves, current controlled arc pulser, cesium boiler redesign, gas mixtures of hydrogen and nitrogen, and duty factor reduction. The studies were performed on the FNAL test stand described in [1], with the aim to improve source lifetime, stability, and reducing the amount of tuning needed.

  12. Overview of Recent Studies and Design Changes for the FNAL Magnetron Ion Source

    Energy Technology Data Exchange (ETDEWEB)

    Bollinger, D. S. [Fermilab; Sosa, A. [Fermilab

    2016-09-06

    This paper will cover several studies and design changes that will eventually be implemented to the Fermi National Accelerator Laboratory (FNAL) magnetron ion source. The topics include tungsten cathode insert, solenoid gas valves, current controlled arc pulser, cesium boiler redesign, gas mixtures of hydrogen and nitrogen, and duty factor reduction. The studies were performed on the FNAL test stand described in [1], with the aim to improve source lifetime, stability, and reducing the amount of tuning needed.

  13. 11-year field study of Pu migration from Pu III, IV, and VI sources

    International Nuclear Information System (INIS)

    Kaplan, D.I.; Serkiz, S.M.; Demirkanli, D.I.; Gumapas, L.; Fjeld, R.A.; Molz, F.J.; Powell, B.A.

    2005-01-01

    Full text of publication follows: Understanding the processes controlling Pu mobility in the subsurface environment is important for estimating the amount of Pu waste that can be safely disposed in vadose zone burial sites. To study long-term Pu mobility, four 52-L lysimeters filled with sediment collected from the Savannah River Site near Aiken South Carolina were amended with well characterized solid Pu sources (Pu III Cl 3 , Pu IV (NO 3 ) 4 , Pu IV (C 2 O 4 ) 2 , and Pu VI O 2 (NO 3 ) 2 ) and left exposed to natural precipitation for 2 to 11 years. Pu oxidation state distribution in the Pu(III) and Pu(IV) lysimeters sediments (a red clayey sediment, pH = 6.3) were similar, consisting of 0% Pu(III), >92% Pu(IV), 1% Pu(V), 1% Pu(VI), and the remainder was a Pu polymer. These three lysimeters also had near identical sediment Pu concentration profiles, where >95% of the Pu remained within 1.25 cm of the source after 11 years; moving at an overall rate of 0.9 cm yr -1 . As expected, Pu moved more rapidly through the Pu(VI) lysimeter, at an overall rate of 12.5 cm yr -1 . Solute transport modeling of the sediment Pu concentration profile data in the Pu(VI) lysimeter indicated that some transformation of Pu into a much less mobile form, presumably Pu(IV), had occurred during the course of the two year study. This modeling also supported previous laboratory measurements showing that Pu(V) or Pu(VI) reduction was five orders of magnitude faster than corresponding Pu(III) or Pu(IV) oxidation. The slow oxidation rate (1 x 10-8 hr -1 ; t 1/2 = 8,000 yr) was not discernable from the Pu(VI) lysimeter data that reflected only two years of transport but was readily discernable from the Pu(III) and Pu(IV) lysimeter data that reflected 11 yr of transport. (authors)

  14. Usefulness of indirect alcohol biomarkers for predicting recidivism of drunk-driving among previously convicted drunk-driving offenders: results from the recidivism of alcohol-impaired driving (ROAD) study.

    Science.gov (United States)

    Maenhout, Thomas M; Poll, Anneleen; Vermassen, Tijl; De Buyzere, Marc L; Delanghe, Joris R

    2014-01-01

    In several European countries, drivers under the influence (DUI), suspected of chronic alcohol abuse are referred for medical and psychological examination. This study (the ROAD study, or Recidivism Of Alcohol-impaired Driving) investigated the usefulness of indirect alcohol biomarkers for predicting drunk-driving recidivism in previously convicted drunk-driving offenders. The ROAD study is a prospective study (2009-13) that was performed on 517 randomly selected drivers in Belgium. They were convicted for drunk-driving for which their licence was confiscated. The initial post-arrest blood samples were collected and analysed for percentage carbohydrate-deficient transferrin (%CDT), transaminsase activities [alanine amino transferase (ALT), aspartate amino transferase (AST)], gamma-glutamyltransferase (γGT) and red cell mean corpuscular volume (MCV). The observation time for each driver was 3 years and dynamic. A logistic regression analysis revealed that ln(%CDT) (P drunk-driving. The ROAD index (which includes ln(%CDT), ln(γGT), -ln(ALT) and the sex of the driver) was calculated and had a significantly higher area under the receiver operator characteristic curve (0.71) than the individual biomarkers for drunk-driving recidivism. Drivers with a high risk of recidivating (ROAD index ≥ 25%; third tertile) could be distinguished from drivers with an intermediate risk (16% ≤ ROAD index drunk-driving. The association with gamma-glutamyltransferase, alanine amino transferase and the sex of the driver could have additional value for identifying drunk-drivers at intermediate risk of recidivism. Non-specific indirect alcohol markers, such as alanine amino transferase, gamma-glutamyltransferase, aspartate amino transferase and red cell mean corpuscular volume have minimal added value to % carbohydrate-deficient transferrin for distinguishing drunk drivers with a low or high risk of recidivism. © 2013 Society for the Study of Addiction.

  15. Preliminary feasibility study on production of cobalt-60 source for industrial irradiation

    International Nuclear Information System (INIS)

    Joo, Po Kook; Park, Kyung Bae; Ahn, Yun Soo; Lee, Jong Tai; Kim, Hark Rho

    1999-05-01

    As there is a high possible demand of industrial Co-60 source in the world market, feasibility study of a project was performed to produce and to export Co-60 sources, utilizing KEPCO's Wolsung NPP for irradiation of cobalt and KAERI's hot-cells for fabrication of cobalt sources. Main concerns of the study were to understand irradiation and fabrication (encapsulation) processes and to examine related technologies, required facilities and equipment. In particular, it was examined intensively if it would be possible to modify facilities around the reactor vessel of Wolsung NPP tp substantiate the related licensing in order to irradiate cobalt in the reactor. It is expected that once, if cooperation scheme with MDS Nordion of Canada is established, main issues such as modification of facilities, related licensing, raw material procurement and technology transfer for high quality product will be solved. In order to review overall feasibility of the project, present status and prospect of the world market was surveyed and various usages of cobalt sources were reviewed with emphasis on possible demand increase per usage. Food poisoning accidents are prevailing worldwide and food irradiation with cobalt sources is considered as a promising measure to prevent them and may bring forth high increase of cobalt sources demand in the world market. Preliminary economic feasibility was studied in conservation, evaluating roughly the investment and the operating cost based on materials from various information sources. (author)

  16. Study on the cathode of ion source for neutral beam injector

    International Nuclear Information System (INIS)

    Tanaka, Shigeru

    1983-08-01

    Durability of the cathode is an important problem in developing a high power long pulse ion source for neutral beam injector. The Purpose of this study is to develope a long life cathode and investigate the applicability of it to the source. Directly heated filaments which are commonly used as the cathode of injector source do not live very long in general. In the present work, an indirectly heated hollow cathode made of impregnated porous tungsten tube is proposed as the alternative of the directly heated cathode. At first, we fabricated a small hollow cathode to study the discharge characteristcs in a bell-jar configuration and to apply it to a duoPIGatron hydrogen ion source. The experiment showed that the gas flow rate for sustaining the stable arc discharge in the discharge chamber becomes higher than that when the filament cathode is used. To solve this problem, an experiment for gas reduction was made using a newly fabricated larger hollow cathode and a magnetic multi-pole ion source. The influence of the orifice diameter, the effect of a button and of magnetic field on the gas flow rate were experimentally studied and a method for gas reduction was found. In addition, effect of the magnetic field on the characteristics of the hollow cathode ion source was examined in detail and an optimum field configuration around the cathode was found. Finally, beam extraction from an intensively cooled hollow cathode ion source for up to 10 sec was successfully carried out. (author)

  17. Source-specific pollution exposure and associations with pulmonary response in the Atlanta Commuters Exposure Studies.

    Science.gov (United States)

    Krall, Jenna R; Ladva, Chandresh N; Russell, Armistead G; Golan, Rachel; Peng, Xing; Shi, Guoliang; Greenwald, Roby; Raysoni, Amit U; Waller, Lance A; Sarnat, Jeremy A

    2018-01-03

    Concentrations of traffic-related air pollutants are frequently higher within commuting vehicles than in ambient air. Pollutants found within vehicles may include those generated by tailpipe exhaust, brake wear, and road dust sources, as well as pollutants from in-cabin sources. Source-specific pollution, compared to total pollution, may represent regulation targets that can better protect human health. We estimated source-specific pollution exposures and corresponding pulmonary response in a panel study of commuters. We used constrained positive matrix factorization to estimate source-specific pollution factors and, subsequently, mixed effects models to estimate associations between source-specific pollution and pulmonary response. We identified four pollution factors that we named: crustal, primary tailpipe traffic, non-tailpipe traffic, and secondary. Among asthmatic subjects (N = 48), interquartile range increases in crustal and secondary pollution were associated with changes in lung function of -1.33% (95% confidence interval (CI): -2.45, -0.22) and -2.19% (95% CI: -3.46, -0.92) relative to baseline, respectively. Among non-asthmatic subjects (N = 51), non-tailpipe pollution was associated with pulmonary response only at 2.5 h post-commute. We found no significant associations between pulmonary response and primary tailpipe pollution. Health effects associated with traffic-related pollution may vary by source, and therefore some traffic pollution sources may require targeted interventions to protect health.

  18. Underestimation of Severity of Previous Whiplash Injuries

    Science.gov (United States)

    Naqui, SZH; Lovell, SJ; Lovell, ME

    2008-01-01

    INTRODUCTION We noted a report that more significant symptoms may be expressed after second whiplash injuries by a suggested cumulative effect, including degeneration. We wondered if patients were underestimating the severity of their earlier injury. PATIENTS AND METHODS We studied recent medicolegal reports, to assess subjects with a second whiplash injury. They had been asked whether their earlier injury was worse, the same or lesser in severity. RESULTS From the study cohort, 101 patients (87%) felt that they had fully recovered from their first injury and 15 (13%) had not. Seventy-six subjects considered their first injury of lesser severity, 24 worse and 16 the same. Of the 24 that felt the violence of their first accident was worse, only 8 had worse symptoms, and 16 felt their symptoms were mainly the same or less than their symptoms from their second injury. Statistical analysis of the data revealed that the proportion of those claiming a difference who said the previous injury was lesser was 76% (95% CI 66–84%). The observed proportion with a lesser injury was considerably higher than the 50% anticipated. CONCLUSIONS We feel that subjects may underestimate the severity of an earlier injury and associated symptoms. Reasons for this may include secondary gain rather than any proposed cumulative effect. PMID:18201501

  19. Previous exposure in a high-risk area for travellers' diarrhoea within the past year is associated with a significant protective effect for travellers' diarrhoea: a prospective observational cohort study in travellers to South Asia.

    Science.gov (United States)

    Kuenzli, Esther; Juergensen, David; Kling, Kerstin; Jaeger, Veronika K; DeCrom, Susan; Steffen, Robert; Widmer, Andreas F; Battegay, Manuel; Hatz, Christoph; Neumayr, Andreas

    2017-09-01

    Travellers' diarrhoea is the most common health problem in travellers. Depending on the region visited, up to 40% of travellers develop diarrhoea during a 2-week trip. The aim of this study was to assess risk factors for TD among travellers to the Indian subcontinent. An observational prospective multicentre cohort study investigated travellers to the Indian subcontinent. Participants completed questionnaires assessing the incidence of travellers' diarrhoea and identifying potential risk factors. Covariates were assessed univariately, followed by a multivariate regression. Two-hundred and twenty-six travellers were enrolled into the study, 178 filled in both pre- and post-travel questionnaires. Overall, the attack rate of travellers' diarrhoea was 38.2%. Travel destination is a key risk factor for the occurrence of TD. Travelling to India or Nepal vs Bhutan is associated with an increased risk for TD (OR 6.68 and 6.62, respectively). A length of stay of more than 3 weeks compared to less than 2 weeks is also associated with a significantly increased risk (OR 5.45). Having stayed in a high-risk area for travellers' diarrhoea within the past year before the current trip is associated with a significantly decreased risk (OR 0.19). No association was found between consumption of high risk food (i.e. tap water, ice cream, raw meat and hamburgers) and travellers' diarrhoea. Travellers' diarrhoea is a frequent problem in travellers to the Indian subcontinent. Previous exposure in a high-risk area for travellers' diarrhoea within the past year appears to have a significant protective effect. Furthermore, an association between the occurrence of travellers' diarrhoea and travel destination and length of stay, respectively, was observed. Consumption of risk food did not confer a TD risk in our study. © International Society of Travel Medicine, 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  20. Myocardial adaption to HI(R)T in previously untrained men with a randomized, longitudinal cardiac MR imaging study (Physical adaptions in Untrained on Strength and Heart trial, PUSH-trial).

    Science.gov (United States)

    Scharf, Michael; Oezdemir, Derya; Schmid, Axel; Kemmler, Wolfgang; von Stengel, Simon; May, Matthias S; Uder, Michael; Lell, Michael M

    2017-01-01

    Although musculoskeletal effects in resistance training are well described, little is known about structural and functional cardiac adaption in formerly untrained subjects. We prospectively evaluated whether short term high intensity (resistance) training (HI(R)T) induces detectable morphologic cardiac changes in previously untrained men in a randomized controlled magnetic resonance imaging (MRI) study. 80 untrained middle-aged men were randomly assigned to a HI(R)T-group (n = 40; 43.5±5.9 years) or an inactive control group (n = 40; 42.0±6.3 years). HI(R)T comprised 22 weeks of training focusing on a single-set to failure protocol in 2-3 sessions/week, each with 10-13 exercises addressing main muscle groups. Repetitions were decreased from 8-10 to 3-5 during study period. Before and after HI(R)T all subjects underwent physiologic examination and cardiac MRI (cine imaging, tagging). Indexed left (LV) and right ventricular (RV) volume (LV: 76.8±15.6 to 78.7±14.8 ml/m2; RV: 77.0±15.5 to 78.7±15.1 ml/m2) and mass (LV: 55.5±9.7 to 57.0±8.8 g/m2; RV: 14.6±3.0 to 15.0±2.9 g/m2) significantly increased with HI(R)T (all pHI(R)T-group did not alter with training (0.73g/mL and 0.19g/mL, respectively [p = 0.96 and p = 0.87]), indicating balanced cardiac adaption. Indexed LV (48.4±11.1 to 50.8±11.0 ml/m2) and RV (48.5±11.0 to 50.6±10.7 ml/m2) stroke volume significantly increased with HI(R)T (pHI(R)T (36.2±7.9 to 37.0±8.4 ml/m2, p = 0.411), the ratio to end-diastolic LV volume at baseline and post-training was unchanged (0.47 vs. 0.47, p = 0.79). 22 weeks of HI(R)T lead to measurable, physiological changes in cardiac atrial and ventricular morphologic characteristics and function in previously untrained men. The PUSH-trial is registered at the US National Institutes of Health (ClinicalTrials.gov), NCT01766791.

  1. The Denver Aerosol Sources and Health (DASH) study: Overview and early findings

    Science.gov (United States)

    Vedal, S.; Hannigan, M. P.; Dutton, S. J.; Miller, S. L.; Milford, J. B.; Rabinovitch, N.; Kim, S.-Y.; Sheppard, L.

    Improved understanding of the sources of air pollution that are most harmful could aid in developing more effective measures for protecting human health. The Denver Aerosol Sources and Health (DASH) study was designed to identify the sources of ambient fine particulate matter (PM 2.5) that are most responsible for the adverse health effects of short-term exposure to PM 2.5. Daily 24-h PM 2.5 sampling began in July 2002 at a residential monitoring site in Denver, Colorado, using both Teflon and quartz filter samplers. Sampling is planned to continue through 2008. Chemical speciation is being carried out for mass, inorganic ionic compounds (sulfate, nitrate and ammonium), and carbonaceous components, including elemental carbon, organic carbon, temperature-resolved organic carbon fractions and a large array of organic compounds. In addition, water-soluble metals were measured daily for 12 months in 2003. A receptor-based source apportionment approach utilizing positive matrix factorization (PMF) will be used to identify PM 2.5 source contributions for each 24-h period. Based on a preliminary assessment using synthetic data, the proposed source apportionment should be able to identify many important sources on a daily basis, including secondary ammonium nitrate and ammonium sulfate, diesel vehicle exhaust, road dust, wood combustion and vegetative debris. Meat cooking, gasoline vehicle exhaust and natural gas combustion were more challenging for PMF to accurately identify due to high detection limits for certain organic molecular marker compounds. Measurements of these compounds are being improved and supplemented with additional organic molecular marker compounds. The health study will investigate associations between daily source contributions and an array of health endpoints, including daily mortality and hospitalizations and measures of asthma control in asthmatic children. Findings from the DASH study, in addition to being of interest to policymakers, by

  2. Use of Z pinch radiation sources for high pressure shock wave studies

    International Nuclear Information System (INIS)

    Asay, J.R.; Konrad, C.H.; Hall, C.A.; Trott, W.M.; Chandler, G.A.; Holland, K.G.; Fleming, K.J.; Trucano, T.G.

    1998-01-01

    Recent developments in pulsed power technology demonstrate use of intense radiation sources (Z pinches) for driving planar shock waves in samples with spatial dimensions larger than possible with other radiation sources. Initial indications are that the use of Z pinch sources can be used to produce planar shock waves in samples with diameters of a few millimeters and thicknesses approaching one half millimeter. These dimensions allow increased accuracy of both shock velocity and particle velocity measurements. The Z pinch radiation source uses imploding metal plasma induced by self-magnetic fields applied to wire arrays to produce high temperature x-ray environments in vacuum hohlraum enclosures. Previous experiments have demonstrated that planar shock waves can be produced with this approach. A photograph of a wire array located inside the vacuum hohlraum is shown here. Typically, a few hundred individual wires are used to produce the Z pinch source. For the shock wave experiments being designed, arrays of 120 to 240 tungsten wires with a diameter of 40 mm and with individual diameters of about 10 microm are used. Preliminary experiments have been performed on the Z pulsed radiation source to demonstrate the ability to obtain VISAR measurements in the Z accelerator environment. Analysis of these results indicate that another effect, not initially anticipated, is an apparent change in refractive index that occurs in the various optical components used in the system. This effect results in an apparent shift in the frequency of reflected laser light, and causes an error in the measured particle velocity. Experiments are in progress to understand and minimize this effect

  3. A study on virtual source position for electron beams from a Mevatron MD linear accelerator

    International Nuclear Information System (INIS)

    Ravindran, B.P.

    1999-01-01

    The virtual source position (VSP) for electron beams of energies 5, 7, 9 10, 12 and 14 MeV and for the applicators (cones) available in the department have been measured for a Mevatron MD class linear accelerator. Different methods of obtaining the virtual source position for electron beams have been investigated in the present study. The results obtained have been compared with those of other workers. It is observed that the VSP is very much machine dependent and needs to be measured for each linear accelerator. The effect of shielding on virtual source position for the type of applicators available in the department has also been investigated. (author)

  4. Simulation study on ion extraction from electron cyclotron resonance ion sources

    Science.gov (United States)

    Fu, S.; Kitagawa, A.; Yamada, S.

    1994-04-01

    In order to study beam optics of NIRS-ECR ion source used in the HIMAC project, the EGUN code has been modified to make it capable of modeling ion extraction from a plasma. Two versions of the modified code are worked out with two different methods in which 1D and 2D sheath theories are used, respectively. Convergence problem of the strong nonlinear self-consistent equations is investigated. Simulations on NIRS-ECR ion source and HYPER-ECR ion source are presented in this paper, exhibiting an agreement with the experiment results.

  5. Study of the spectral characteristics of unidentified galactic EGRET sources. Are they pulsar-like?

    Science.gov (United States)

    Merck, M.; Bertsch, D. L.; Dingus, B. L.; Esposito, J. A.; Fichtel, C. E.; Fierro, J. M.; Hartman, R. C.; Hunter, S. D.; Kanbach, G.; Kniffen, D. A.; Lin, Y. C.; Mayer-Hasselwander, H. A.; Michelson, P. F.; von Montigny, C.; Muecke, A.; Mukherjee, R.; Nolan, P. L.; Pohl, M.; Schneid, E.; Sreekumar, P.; Thompson, D. J.; Willis, T. D.

    1996-12-01

    A spectral study of unidentified galactic EGRET sources was performed. The derived spectra are compared to the spectra of pulsars to test the hypothesis, that a significant fraction of these sources are Geminga like radio-quiet pulsars (Yadigaroglu & Romani 1995ApJ...449..211Y). Most of the sources show significantly different spectra than expected under this hypothesis. Of those with spectra consistent with typical pulsar spectra, four are positionally consistent with young spin-powered radio pulsars leaving only very few Geminga type candidates in the sample.

  6. A Detailed Study of Debris Flow Source Areas in the Northern Colorado Front Range.

    Science.gov (United States)

    Arana-Morales, A.; Baum, R. L.; Godt, J.

    2014-12-01

    Nearly continuous, heavy rainfall occurred during 9-13 September 2013 causing flooding and widespread landslides and debris flows in the northern Colorado Front Range. Whereas many recent studies have identified erosion as the most common process leading to debris flows in the mountains of Colorado, nearly all of the debris flows mapped in this event began as small, shallow landslides. We mapped the boundaries of 415 September 2013 debris flows in the Eldorado Springs and Boulder 7.5-minute quadrangles using 0.5-m-resolution satellite imagery. We characterized the landslide source areas of six debris flows in the field as part of an effort to identify what factors controlled their locations. Four were on a dip slope in sedimentary rocks in the Pinebrook Hills area, near Boulder, and the other two were in granitic rocks near Gross Reservoir. Although we observed no obvious geomorphic differences between the source areas and surrounding non-landslide areas, we noted several characteristics that the source areas all had in common. Slopes of the source areas ranged from 28° to 35° and most occurred on planar or slightly concave slopes that were vegetated with grass, small shrubs, and sparse trees. The source areas were shallow, irregularly shaped, and elongated downslope: widths ranged from 4 to 9 m, lengths from 6 to 40 m and depths ranged from 0.7 to 1.2 m. Colluvium was the source material for all of the debris flows and bedrock was exposed in the basal surface of all of the source areas. We observed no evidence for concentrated surface runoff upslope from the sources. Local curvature and roughness of bedrock and surface topography, and depth distribution and heterogeneity of the colluvium appear to have controlled the specific locations of these shallow debris-flow source areas. The observed distribution and characteristics of the source areas help guide ongoing efforts to model initiation of the debris flows.

  7. Feasibility study on X-ray source with pinhole imaging method

    International Nuclear Information System (INIS)

    Qiu Rui; Li Junli

    2007-01-01

    In order to verify the feasibility of study on X-ray source with pinhole imaging method, and optimize the design of X-ray pinhole imaging system, an X-ray pinhole imaging equipment was set up. The change of image due to the change of the position and intensity of X-ray source was estimated with mathematical method and validated with experiment. The results show that the change of the spot position and gray of the spot is linearly related with the change of the position and intensity of X-ray source, so it is feasible to study X-ray source with pinhole imaging method in this application. The results provide some references for the design of X-ray pinhole imaging system. (authors)

  8. Time-resolved X-ray studies using third generation synchrotron radiation sources

    International Nuclear Information System (INIS)

    Mills, D.M.

    1991-10-01

    The third generation, high-brilliance, hard x-ray, synchrotron radiation (SR) sources currently under construction (ESRF at Grenoble, France; APS at Argonne, Illinois; and SPring-8 at Harima, Japan) will usher in a new era of x-ray experimentation for both physical and biological sciences. One of the most exciting areas of experimentation will be the extension of x-ray scattering and diffraction techniques to the study of transient or time-evolving systems. The high repetition rate, short-pulse duration, high brilliance, and variable spectral bandwidth of these sources make them ideal for x-ray time-resolved studies. The temporal properties (bunch length, interpulse period, etc.) of these new sources will be summarized. Finally, the scientific potential and the technological challenges of time-resolved x-ray scattering from these new sources will be described. 13 refs., 4 figs

  9. Neutron activation analysis: Modelling studies to improve the neutron flux of Americium-Beryllium source

    Energy Technology Data Exchange (ETDEWEB)

    Didi, Abdessamad; Dadouch, Ahmed; Tajmouati, Jaouad; Bekkouri, Hassane [Advanced Technology and Integration System, Dept. of Physics, Faculty of Science Dhar Mehraz, University Sidi Mohamed Ben Abdellah, Fez (Morocco); Jai, Otman [Laboratory of Radiation and Nuclear Systems, Dept. of Physics, Faculty of Sciences, Tetouan (Morocco)

    2017-06-15

    Americium–beryllium (Am-Be; n, γ) is a neutron emitting source used in various research fields such as chemistry, physics, geology, archaeology, medicine, and environmental monitoring, as well as in the forensic sciences. It is a mobile source of neutron activity (20 Ci), yielding a small thermal neutron flux that is water moderated. The aim of this study is to develop a model to increase the neutron thermal flux of a source such as Am-Be. This study achieved multiple advantageous results: primarily, it will help us perform neutron activation analysis. Next, it will give us the opportunity to produce radio-elements with short half-lives. Am-Be single and multisource (5 sources) experiments were performed within an irradiation facility with a paraffin moderator. The resulting models mainly increase the thermal neutron flux compared to the traditional method with water moderator.

  10. Eggshell powder, a comparable or better source of calcium than purified calcium carbonate: Piglet studies

    NARCIS (Netherlands)

    Schaafsma, A.; Beelen, G.M.

    1999-01-01

    Powdered chicken eggshells might be an interesting and widely available source of calcium. In two studies using piglets we determined the digestibility of calcium from different diets. The first study compared casein-based diets with CaCO3 (CasCC) or eggshell powder (CasES). The second study

  11. Leveraging Literacies through Collaborative, Source-Based Planning and Teaching in Social Studies and Language Arts

    Science.gov (United States)

    Patterson, Nancy; Weaver, Joanna; Fletcher, Jamie; Connor, Bryce; Thomas, Angela; Ross, Cindy

    2018-01-01

    The value of preparing students for college, careers, and civic life is a shared outcome of social studies and language arts teachers. This study explores how developing content and civic literacy to these ends can be fortified through language arts and social studies teacher collaboration in source-based planning and teaching. Although numerous…

  12. Source study of local coalfield events using the modal synthesis of shear and surface waves

    Energy Technology Data Exchange (ETDEWEB)

    MacBeth, C.D.; Redmayne, D.W.

    1989-10-01

    Results from the BGS LOWNET array from the Midlothian coalfield in Scotland have been studied. Vertical component seismograms have been analysed using a waveform matching technique based on the modal summation method for constructing synthetic seismograms. Results of the analysis are applied to S and surface wave portions of the seismogram. Effects of different earth structures, source depths, source orientation, and type of event, rockburst or triggered earthquake 2-3 km from the mine workings, can be evaluated.

  13. Automated Source Code Analysis to Identify and Remove Software Security Vulnerabilities: Case Studies on Java Programs

    OpenAIRE

    Natarajan Meghanathan

    2013-01-01

    The high-level contribution of this paper is to illustrate the development of generic solution strategies to remove software security vulnerabilities that could be identified using automated tools for source code analysis on software programs (developed in Java). We use the Source Code Analyzer and Audit Workbench automated tools, developed by HP Fortify Inc., for our testing purposes. We present case studies involving a file writer program embedded with features for password validation, and ...

  14. THE LIS STUDY (LYUBERTSY STUDY ON MORTALITY RATE IN PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION. EVALUATION OF DRUG THERAPY. PART 2. INFLUENCE OF PREVIOUS DRUG TREATMENT ON LONG-TERM LIFE PROGNOSIS

    Directory of Open Access Journals (Sweden)

    S. Yu. Martsevich

    2015-12-01

    Full Text Available Aim. To evaluate drug therapy received by patients who had survived acute myocardial infarction (AMI in the framework of the AMI register (the “LIS” study and estimate this therapy influence on long-term outcomes of the disease. Material and methods. The total of 961 patients of 1133 enrolled in the “LIS” study , were discharged from hospital. 191 patients had died during follow-up. 632 patients (who had survived and consented to visit out-patient clinic underwent repeated examination (median of follow-up 1.6 [1.0; 2.4] years. Data about treatment before and during AMI were received from patient’s charts; data about treatment after AMI were obtained from out-patient medical records. Results. Before reference AMI only a small number of the patients received the main drug groups (antiplatelet agents, β-blockers, ACE inhibitors, statins, at that ACE inhibitors were prescribed more often than the others. Use of β-blockers and ACE inhibitors before reference AMI significantly improved long-term life prognosis [relative risk (RR 0.70 and 0.66, respectively]. Rate of the main drug groups prescribed in hospital was rather high with the exception of thrombolytics (less than 10%. Thrombolytics, β-blockers and antiplatelet agents prescribed in hospital significantly improved long-term life prognosis of patients (RR 0.42, 0.65 and 0.58 respectively. At the second visit (according to data of out-patient medical records rate of antiplatelet agents, ACE inhibitors, β-blockers and statins prescription exceeded 60%. Conclusion. Very low prevalence of adequate drug therapy preceding AMI determines high mortality rate among survived acute stage of myocardial infarction patients in long-term period.

  15. Automatic electromagnetic valve for previous vacuum

    International Nuclear Information System (INIS)

    Granados, C. E.; Martin, F.

    1959-01-01

    A valve which permits the maintenance of an installation vacuum when electric current fails is described. It also lets the air in the previous vacuum bomb to prevent the oil ascending in the vacuum tubes. (Author)

  16. Study of classification and disposed method for disused sealed radioactive source in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Suk Hoon; Kim, Ju Youl; Lee, Seung Hee [FNC Technology Co., Ltd.,Yongin (Korea, Republic of)

    2016-09-15

    In accordance with the classification system of radioactive waste in Korea, all the disused sealed radioactive sources (DSRSs) fall under the category of EW, VLLW or LILW, and should be managed in compliance with the restrictions for the disposal method. In this study, the management and disposal method are drawn in consideration of half-life of radionuclides contained in the source and A/D value (i.e. the activity A of the source dividing by the D value for the relevant radionuclide, which is used to provide an initial ranking of relative risk for sources) in addition to the domestic classification scheme and disposal method, based on the characteristic analysis and review results of the management practices in IAEA and foreign countries. For all the DSRSs that are being stored (as of March 2015) in the centralized temporary disposal facility for radioisotope wastes, applicability of the derivation result is confirmed through performing the characteristic analysis and case studies for assessing quantity and volume of DSRSs to be managed by each method. However, the methodology derived from this study is not applicable to the following sources; i) DSRSs without information on the radioactivity, ii) DSRSs that are not possible to calculate the specific activity and/or the source-specific A/D value. Accordingly, it is essential to identify the inherent characteristics for each of DSRSs prior to implementation of this management and disposal method.

  17. Predictive Big Data Analytics: A Study of Parkinson?s Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations

    OpenAIRE

    Dinov, Ivo D.; Heavner, Ben; Tang, Ming; Glusman, Gustavo; Chard, Kyle; Darcy, Mike; Madduri, Ravi; Pa, Judy; Spino, Cathie; Kesselman, Carl; Foster, Ian; Deutsch, Eric W.; Price, Nathan D.; Van Horn, John D.; Ames, Joseph

    2016-01-01

    Background A unique archive of Big Data on Parkinson?s Disease is collected, managed and disseminated by the Parkinson?s Progression Markers Initiative (PPMI). The integration of such complex and heterogeneous Big Data from multiple sources offers unparalleled opportunities to study the early stages of prevalent neurodegenerative processes, track their progression and quickly identify the efficacies of alternative treatments. Many previous human and animal studies have examined the relationsh...

  18. The COLOFOL trial: study design and comparison of the study population with the source cancer population

    Directory of Open Access Journals (Sweden)

    Hansdotter Andersson P

    2016-01-01

    eligible patients. However, a difference was noted in tumor location and stage distribution, with 5.6% more patients in the randomized group having colon cancer and 6.7% more patients having stage II disease. Conclusion: Patients in the two study arms were not only demographically similar, but also similar to nonincluded eligible patients, apart from stage and localization. The analyses will be stratified by these variables. Taken together, we conclude that our trial results will be robust and possible to extrapolate to the target population. Keywords: trial design, source population, colorectal cancer, follow-up

  19. A Study on Conjugate Heat Transfer Analysis of Reactor Vessel including Irradiated Structural Heat Source

    Energy Technology Data Exchange (ETDEWEB)

    Yi, Kunwoo; Cho, Hyuksu; Im, Inyoung; Kim, Eunkee [KEPCO EnC, Daejeon (Korea, Republic of)

    2015-10-15

    Though Material reliability programs (MRPs) have a purpose to provide the evaluation or management methodologies for the operating RVI, the similar evaluation methodologies can be applied to the APR1400 fleet in the design stage for the evaluation of neutron irradiation effects. The purposes of this study are: to predict the thermal behavior whether or not irradiated structure heat source; to evaluate effective thermal conductivity (ETC) in relation to isotropic and anisotropic conductivity of porous media for APR1400 Reactor Vessel. The CFD simulations are performed so as to evaluate thermal behavior whether or not irradiated structure heat source and effective thermal conductivity for APR1400 Reactor Vessel. In respective of using irradiated structure heat source, the maximum temperature of fluid and core shroud for isotropic ETC are 325.8 .deg. C, 341.5 .deg. C. The total amount of irradiated structure heat source is about 5.41 MWth and not effect to fluid temperature.

  20. Dosimetry studies with 32P source and correlation of skin and eye lens doses

    International Nuclear Information System (INIS)

    Kumar, Munish; Gaonkar, U.P.; Koul, D.K.; Datta, D.; Saxena, S.K.; Kumar, Yogendra; Dash, A.

    2018-01-01

    Beta particles are one of the major contributors toward skin and eye lens doses at facilities handling beta sources. These sources find applications in industry, pharmaceuticals as well as in brachytherapy applications. The beta particles having maximum (E max ) energy > 0.07 MeV are capable of delivering skin dose whereas beta particles having maximum (E max ) energy > 0.7 MeV may also contribute towards dose to eye lens. Studies are performed using 32 P beta source as its maximum beta energy (E max ) is such that for sources having (E max ) of 1.71 MeV or beyond, there can be substantial contribution towards dose to eye lens even the dose limit recommended for skin is followed

  1. Study and development of a new ECR source creating an intense light ions beam

    International Nuclear Information System (INIS)

    Nyckees, S.

    2012-01-01

    This thesis is in the context of study and design of a new ECR light ion source on LEDA (Laboratory of Research and Development of Accelerators - CEA Saclay), named ALISES (Advanced Light Ions Source Extraction System). As a first step, the magnetic, electrical and mechanical design of the new source is described. Then, simulations were performed to determine the reduction of emittance growth taking into account the reduction of the length of the LBE (Low Energy Beam Line) provided by the source ALISES. With this source, it's also possible to realize a study on the dimensions of the cylindrical plasma chamber. Simulations were performed to better understand the interaction between radiofrequency wave and plasma. Subsequently, experiments on the source ALISES helped highlight, understand and solve problems in the Penning discharges inside the accelerator column. Measurements performed on the plasma have yielded the assumption that the electrons are heated at the entrance of the plasma chamber and thermalized along its entire length to achieve an energy corresponding to the maximum of the ionization cross section for hydrogen. (author) [fr

  2. Sexual knowledge, attitude, behaviors and sources of influences in Urban college youth: A study from India

    Directory of Open Access Journals (Sweden)

    Siddharth Dutt

    2017-01-01

    Full Text Available Background: The study was undertaken as there is very less literature related to sources of influence for sexual knowledge and attitude toward sex and sexual behaviors of youth in India. Aim: The objectives of the study were to explore sexual knowledge, attitudes, behaviors and the sources of influence and also to examine the relationship between sexual knowledge, attitude and behaviors in the youth. Method: The sample was selected from colleges using purposive sampling method and from the community using snowball method (n = 300. The tools used were sociodemographic data sheet, Sexual Knowledge and Attitude Questionnaire (SKAQ-II and Sexual Behavior and Sources of Influence (SBSI scale. Results: Descriptive statistics and correlation was done to analyze the data. The youth had poor sexual knowledge; there was positive relationship between sexual knowledge and attitudes. Sexual behaviors through media and with self or others were found to be low. Internet was found to be the major source for gathering information and was considered the most reliable source. Conclusion: Indian college youth continue to have poor sexual knowledge. Internet is a major source of information and is considered as the most reliable one among youth. More knowledge about sex is associated with liberal attitude toward sex.

  3. A technique to consider mismatches between fMRI and EEG/MEG sources for fMRI-constrained EEG/MEG source imaging: a preliminary simulation study

    International Nuclear Information System (INIS)

    Im, Chang-Hwan; Lee, Soo Yeol

    2006-01-01

    fMRI-constrained EEG/MEG source imaging can be a powerful tool in studying human brain functions with enhanced spatial and temporal resolutions. Recent studies on the combination of fMRI and EEG/MEG have suggested that fMRI prior information could be readily implemented by simply imposing different weighting factors to cortical sources overlapping with the fMRI activations. It has been also reported, however, that such a hard constraint may cause severe distortions or elimination of meaningful EEG/MEG sources when there are distinct mismatches between the fMRI activations and the EEG/MEG sources. If one wants to obtain the actual EEG/MEG source locations and uses the fMRI prior information as just an auxiliary tool to enhance focality of the distributed EEG/MEG sources, it is reasonable to weaken the strength of fMRI constraint when severe mismatches between fMRI and EEG/MEG sources are observed. The present study suggests an efficient technique to automatically adjust the strength of fMRI constraint according to the mismatch level. The use of the proposed technique rarely affects the results of conventional fMRI-constrained EEG/MEG source imaging if no major mismatch between the two modalities is detected; while the new results become similar to those of typical EEG/MEG source imaging without fMRI constraint if the mismatch level is significant. A preliminary simulation study using realistic EEG signals demonstrated that the proposed technique can be a promising tool to selectively apply fMRI prior information to EEG/MEG source imaging

  4. The training of Olympic wrestling coaches: study of the sources of knowledge and essential training contents

    Directory of Open Access Journals (Sweden)

    Paulo Martins

    2017-08-01

    Full Text Available The aim of this study was to analyze the representation of wrestling coaches regarding the sources of knowledge and the training contents to be adopted during the training process of young wrestlers’ coaches. The study was based on Grossman’s (1990 model of professional knowledge for teaching and followed a qualitative, multiple case study methodology. Following a semi-structured script, six Olympic wrestling experts were interviewed in-depth, trying to identify the sources of knowledge that the coaches used for their training and what didactic-methodological contents they considered essential to play their role as coach. The analysis revealed that the coaches’ sources of professional knowledge were diverse, including academic training and professional experience as the main sources of access to professional knowledge. The coaches also pointed out that their first sources of knowledge were their experiences as competitive athletes. Finally, this study concludes that expert coaches must acquire a profound knowledge of the competition environment, seeking to optimize their influence on athletes, which should extend not only to the sport practice of the youngster – as an athlete – but also at the level of the athlete as a person.

  5. Dynamic energy converters using an outer heat source for ground uses. Bibliographic study

    International Nuclear Information System (INIS)

    Bousquet, Jean-Louis du

    1969-01-01

    This short bibliographical review presents the main dynamical conversion systems operating with an outer heat source, used for power ranges of a few hundreds Watts to a few hundreds kilowatts and dedicated to ground uses. The study has three parts: recollection of thermodynamic cycles; review of some present or projected realizations; a critical study for selecting converter components (turbine, reciprocating engine, thermodynamical fluid) [fr

  6. Environmental evaluation of high-value agricultural produce with diverse water sources: case study from Southern California

    Science.gov (United States)

    Bell, Eric M.; Stokes-Draut, Jennifer R.; Horvath, Arpad

    2018-02-01

    Meeting agricultural demand in the face of a changing climate will be one of the major challenges of the 21st century. California is the single largest agricultural producer in the United States but is prone to extreme hydrologic events, including multi-year droughts. Ventura County is one of California’s most productive growing regions but faces water shortages and deteriorating water quality. The future of California’s agriculture is dependent on our ability to identify and implement alternative irrigation water sources and technologies. Two such alternative water sources are recycled and desalinated water. The proximity of high-value crops in Ventura County to both dense population centers and the Pacific Ocean makes it a prime candidate for alternative water sources. This study uses highly localized spatial and temporal data to assess life-cycle energy use, life-cycle greenhouse gas emissions, operational costs, applied water demand, and on-farm labor requirements for four high-value crops. A complete switch from conventional irrigation with groundwater and surface water to recycled water would increase the life-cycle greenhouse gas emissions associated with strawberry, lemon, celery, and avocado production by approximately 14%, 7%, 59%, and 9%, respectively. Switching from groundwater and surface water to desalinated water would increase life-cycle greenhouse gas emissions by 33%, 210%, 140%, and 270%, respectively. The use of recycled or desalinated water for irrigation is most financially tenable for strawberries due to their relatively high value and close proximity to water treatment facilities. However, changing strawberry packaging has a greater potential impact on life-cycle energy use and greenhouse gas emissions than switching the water source. While this analysis does not consider the impact of water quality on crop yields, previous studies suggest that switching to recycled water could result in significant yield increases due to its lower

  7. Noise disturbance in open-plan study environments : a field study on noise sources, student tasks and room acoustic parameters

    NARCIS (Netherlands)

    Braat-Eggen, P.E.; van Heijst, A.W.M.; Hornikx, M.C.J.; Kohlrausch, A.G.

    2017-01-01

    The aim of this study is to gain more insight in the assessment of noise in open-plan study environments and to reveal correlations between noise disturbance experienced by students and the noise sources they perceive, the tasks they perform and the acoustic parameters of the open-plan study

  8. Revealing transboundary and local air pollutant sources affecting Metro Manila through receptor modeling studies

    International Nuclear Information System (INIS)

    Pabroa, Preciosa Corazon B.; Bautista VII, Angel T.; Santos, Flora L.; Racho, Joseph Michael D.

    2011-01-01

    Ambient fine particulate matter (PM 2 .5) levels at the Metro Manila air sampling stations of the Philippine Nuclear Research Research Institute were found to be above the WHO guideline value of 10 μg m 3 indicating, in general, very poor air quality in the area. The elemental components of the fine particulate matter were obtained using the energy-dispersive x-ray fluorescence spectrometry. Positive matrix factorization, a receptor modelling tool, was used to identify and apportion air pollution sources. Location of probable transboundary air pollutants were evaluated using HYSPLIT (Hybrid Single Particle Lagrangian Integrated Trajectory Model) while location of probable local air pollutant sources were determined using the conditional probability function (CPF). Air pollutant sources can either be natural or anthropogenic. This study has shown natural air pollutant sources such as volcanic eruptions from Bulusan volcano in 2006 and from Anatahan volcano in 2005 to have impacted on the region. Fine soils was shown to have originated from China's Mu US Desert some time in 2004. Smoke in the fine fraction in 2006 show indications of coming from forest fires in Sumatra and Borneo. Fine particulate Pb in Valenzuela was shown to be coming from the surrounding area. Many more significant air pollution impacts can be evaluated with the identification of probable air pollutant sources with the use of elemental fingerprints and locating these sources with the use of HYSPLIT and CPF. (author)

  9. Source rock contributions to the Lower Cretaceous heavy oil accumulations in Alberta: a basin modeling study

    Science.gov (United States)

    Berbesi, Luiyin Alejandro; di Primio, Rolando; Anka, Zahie; Horsfield, Brian; Higley, Debra K.

    2012-01-01

    The origin of the immense oil sand deposits in Lower Cretaceous reservoirs of the Western Canada sedimentary basin is still a matter of debate, specifically with respect to the original in-place volumes and contributing source rocks. In this study, the contributions from the main source rocks were addressed using a three-dimensional petroleum system model calibrated to well data. A sensitivity analysis of source rock definition was performed in the case of the two main contributors, which are the Lower Jurassic Gordondale Member of the Fernie Group and the Upper Devonian–Lower Mississippian Exshaw Formation. This sensitivity analysis included variations of assigned total organic carbon and hydrogen index for both source intervals, and in the case of the Exshaw Formation, variations of thickness in areas beneath the Rocky Mountains were also considered. All of the modeled source rocks reached the early or main oil generation stages by 60 Ma, before the onset of the Laramide orogeny. Reconstructed oil accumulations were initially modest because of limited trapping efficiency. This was improved by defining lateral stratigraphic seals within the carrier system. An additional sealing effect by biodegraded oil may have hindered the migration of petroleum in the northern areas, but not to the east of Athabasca. In the latter case, the main trapping controls are dominantly stratigraphic and structural. Our model, based on available data, identifies the Gordondale source rock as the contributor of more than 54% of the oil in the Athabasca and Peace River accumulations, followed by minor amounts from Exshaw (15%) and other Devonian to Lower Jurassic source rocks. The proposed strong contribution of petroleum from the Exshaw Formation source rock to the Athabasca oil sands is only reproduced by assuming 25 m (82 ft) of mature Exshaw in the kitchen areas, with original total organic carbon of 9% or more.

  10. The vibrational source strength descriptor using power input from equivalent forces: a simulation study

    DEFF Research Database (Denmark)

    Laugesen, Søren; Ohlrich, Mogens

    1994-01-01

    Simple, yet reliable methods for the approximate determination of the vibratory power supplied by the internal excitation forces of a given vibrational source are of great interest. One such method that relies on the application of a number of “equivalent forces” and measurements of the mean...... squared velocity on either the source or the receiving structure is studied in this paper by means of computer simulations. The study considers a simple system of two flexural beams coupled via a pair of springs. The investigation shows that a relatively small number of equivalent forces suffice...

  11. Experimental Melting Study of Basalt-Peridotite Hybrid Source: Melting model of Hawaiian plume

    Science.gov (United States)

    Takahashi, E.; Gao, S.

    2015-12-01

    Eclogite component entrained in ascending plume is considered to be essentially important in producing flood basalts (e.g., Columbia River basalt, Takahashi et al., 1998 EPSL), alkalic OIBs (e.g., Kogiso et al.,2003), ferro-picrites (Tuff et al.,2005) and Hawaiian shield lavas (e.g., Hauri, 1996; Takahashi & Nakajima, 2002, Sobolev et al.,2005). Size of the entrained eclogite, which controls the reaction rates with ambient peridotite, however, is very difficult to constrain using geophysical observation. Among Hawaiian shield volcanoes, Koolau is the most enriched end-member in eclogite component (Frey et al, 1994). Reconstruction of Koolau volcano based on submarine study on Nuuanu landslide (AGU Monograph vol.128, 2002, Takahashi Garcia Lipman eds.) revealed that silica-rich tholeiite appeared only at the last stage (Makapuu stage) of Koolau volcano. Chemical compositions of lavas as well as isotopes change abruptly and coherently across a horizon (Shinozaki et al. and Tanaka et al. ibid.). Based on these observation, Takahashi & Nakajima (2002 ibid) proposed that the Makapuu stage lava in Koolau volcano was supplied from a single large eclogite block. In order to study melting process in Hawaiian plume, high-pressure melting experiments were carried out under dry and hydrous conditions with layered eclogite/peridotite starting materials. Detail of our experiments will be given by Gao et al (2015 AGU). Combined previous field observation with new set of experiments, we propose that variation in SiO2 among Hawaiian tholeiites represent varying degree of wall-rock interaction between eclogite and ambient peridotite. Makapuu stage lavas in Koolau volcano represents eclogite partial melts formed at ~3 GPa with various amount of xenocrystic olivines derived from Pacific plate. In other words, we propose that "primary magma" in the melting column of Hawaiian plume ranges from basaltic andesite to ferro-picrite depending on the lithology of the source. Solidus of

  12. 77 FR 70176 - Previous Participation Certification

    Science.gov (United States)

    2012-11-23

    ... participants' previous participation in government programs and ensure that the past record is acceptable prior... information is designed to be 100 percent automated and digital submission of all data and certifications is... government programs and ensure that the past record is acceptable prior to granting approval to participate...

  13. Previous experiences shape adaptive mate preferences

    NARCIS (Netherlands)

    Fawcett, Tim W.; Bleay, Colin

    2009-01-01

    Existing models of mate choice assume that individuals have perfect knowledge of their own ability to attract a mate and can adjust their preferences accordingly. However, real animals will typically be uncertain of their own attractiveness. A potentially useful source of information on this is the

  14. Randomized Phase II Study of R-CHOP With or Without Bortezomib in Previously Untreated Patients With Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.

    Science.gov (United States)

    Leonard, John P; Kolibaba, Kathryn S; Reeves, James A; Tulpule, Anil; Flinn, Ian W; Kolevska, Tatjana; Robles, Robert; Flowers, Christopher R; Collins, Robert; DiBella, Nicholas J; Papish, Steven W; Venugopal, Parameswaran; Horodner, Andrew; Tabatabai, Amir; Hajdenberg, Julio; Park, Jaehong; Neuwirth, Rachel; Mulligan, George; Suryanarayan, Kaveri; Esseltine, Dixie-Lee; de Vos, Sven

    2017-11-01

    Purpose To evaluate the impact of the addition of bortezomib to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) on outcomes in previously untreated patients with non-germinal center B-cell-like (non-GCB) diffuse large B-cell lymphoma (DLBCL). Patients and Methods After real-time determination of non-GCB DLBCL using the Hans immunohistochemistry algorithm, 206 patients were randomly assigned (1:1; stratified by International Prognostic Index [IPI] score) to six 21-day cycles of standard R-CHOP alone or R-CHOP plus bortezomib 1.3 mg/m 2 intravenously on days 1 and 4 (VR-CHOP). The primary end point, progression-free survival (PFS), was evaluated in 183 patients with centrally confirmed non-GCB DLBCL who received one or more doses of study drug (91 R-CHOP, 92 VR-CHOP). Results After a median follow-up of 34 months, with 25% (R-CHOP) and 18% (VR-CHOP) of patients having had PFS events, the hazard ratio (HR) for PFS was 0.73 (90% CI, 0.43 to 1.24) with VR-CHOP ( P = .611). Two-year PFS rates were 77.6% with R-CHOP and 82.0% with VR-CHOP; they were 65.1% versus 72.4% in patients with high-intermediate/high IPI (HR, 0.67; 90% CI, 0.34 to 1.29), and 90.0% versus 88.9% (HR, 0.85; 90% CI, 0.35 to 2.10) in patients with low/low-intermediate IPI. Overall response rate with R-CHOP and VR-CHOP was 98% and 96%, respectively. The overall survival HR was 0.75 (90% CI, 0.38 to 1.45); 2-year survival rates were 88.4% and 93.0%, respectively. In the safety population (100 R-CHOP and 101 VR-CHOP patients), grade ≥ 3 adverse events included neutropenia (53% v 49%), thrombocytopenia (13% v 29%), anemia (7% v 15%), leukopenia (26% v 25%), and neuropathy (1% v 5%). Conclusion Outcomes for newly diagnosed, prospectively enrolled patients with non-GCB DLBCL were more favorable than expected with R-CHOP and were not significantly improved by adding bortezomib.

  15. Experimental study on the temperature conditions for rod and plane irradiators with 60Co source

    International Nuclear Information System (INIS)

    Stepanov, G.D.; Osipov, V.B.; Sarapkin, I.I.; Chizhikov, V.A.

    1977-01-01

    The formation of a temperature field of rod and flat 60 Co irradiators has been studied. The experiments are carried out on a gamma installation. It has been shown that for a stationary operating mode the maximum cassette temperature (when the cassette contains a 60 Co source) is 148 deg C at maximum permissible temperature of 250 deg C. When ampoules containing the sources with maximum activity (640 Ci) are loaded into cassettes they have the temperature of 184 deg C. The reciprocal screening influence of rod irradiators gives the temperature rise of 8-10 deg in each element. The irradiators under study reach a stationary thermal operating mode in 150 min after the sources are elevated to the operating position

  16. Preliminary studies of adaptation of Self- efficacy Scale for Sources of Mathematics

    Directory of Open Access Journals (Sweden)

    Ramírez Flores, Celia María

    2011-07-01

    Full Text Available In the field of educational psychologically the construct of self-efficacy has received special attention. It has been shown that those students who trust in their own abilities get better academic performance. However, few studies analyze the sources of self-efficacy. Self-efficacy believes are developed according to how people interpret information coming from four different sources: experience skills, vicarious learning, social persuasion, and physiological states. Recently, Usher & Pajares (2009 developed an instrument to assess sources of self-efficacy in Math. The goal of the present work was to evaluate psychometric properties of this scale in a local sample of adolescents from 13 to 15 years old. Preliminary results supported the use of this measure as an adequate alternative to assess self-efficacy in Math. However, more studies are needed in order to obtain a measure more contextualized to the educational system of local students.

  17. Newly graduated nurses use of knowledge sources in clinical decison-making - a qualitative study

    DEFF Research Database (Denmark)

    Voldbjerg, Siri

    of clinical decisions, based on transparent, articulate and reflective use of knowledge sources. Furthermore, it is implied that nurses are able to retrieve, asses, implement and evaluate research evidence. To meet these requirements, nursing educations around the world have organised curricula to educate...... graduated nurses do not work within a framework of evidence-based practice. The overall aim of this thesis was to explore which knowledge sources newly graduated nurses’ use in their clinical decision-making and why they use them in order to understand why newly graduated nurses use research and components...... within evidence-based practice to a limited extent. The thesis is based on a synthesis of findings from two studies. The aim of the first study was to explore which knowledge sources newly graduated nurses use in clinical decision making as reported within international qualitative research. The purpose...

  18. Dietary sources of polyphenols in the Mediterranean healthy Eating, Aging and Lifestyle (MEAL) study cohort.

    Science.gov (United States)

    Godos, Justyna; Marventano, Stefano; Mistretta, Antonio; Galvano, Fabio; Grosso, Giuseppe

    2017-09-01

    The aim of this study was to estimate the dietary intake and major food sources of polyphenols in the Mediterranean healthy Eating, Aging and Lifestyles (MEAL) study cohort. A total of 1937 individuals (18 + y) of urban population of Catania, Italy, completed a validated 110-item food frequency questionnaire; Phenol-Explorer database was used to estimate polyphenol intake. Mean intake of polyphenols was 663.7 mg/d; the most abundant classes were phenolic acids (362.7 mg/d) and flavonoids (258.7 mg/d). The main dietary sources of total polyphenols were nuts, followed by tea and coffee as source of flavanols and hydroxycinnamic acids, respectively, fruits (i.e. cherries were sources of anthocyanins and citrus fruits of flavanones) and vegetables (i.e. artichokes and olives were sources of flavones and spinach and beans of flavonols); chocolate, red wine and pasta contributed to flavanols and tyrosols, respectively. These findings will be useful to assess the potential benefits of foods with high polyphenol content.

  19. Development and validation of an open source quantification tool for DSC-MRI studies.

    Science.gov (United States)

    Gordaliza, P M; Mateos-Pérez, J M; Montesinos, P; Guzmán-de-Villoria, J A; Desco, M; Vaquero, J J

    2015-03-01

    This work presents the development of an open source tool for the quantification of dynamic susceptibility-weighted contrast-enhanced (DSC) perfusion studies. The development of this tool is motivated by the lack of open source tools implemented on open platforms to allow external developers to implement their own quantification methods easily and without the need of paying for a development license. This quantification tool was developed as a plugin for the ImageJ image analysis platform using the Java programming language. A modular approach was used in the implementation of the components, in such a way that the addition of new methods can be done without breaking any of the existing functionalities. For the validation process, images from seven patients with brain tumors were acquired and quantified with the presented tool and with a widely used clinical software package. The resulting perfusion parameters were then compared. Perfusion parameters and the corresponding parametric images were obtained. When no gamma-fitting is used, an excellent agreement with the tool used as a gold-standard was obtained (R(2)>0.8 and values are within 95% CI limits in Bland-Altman plots). An open source tool that performs quantification of perfusion studies using magnetic resonance imaging has been developed and validated using a clinical software package. It works as an ImageJ plugin and the source code has been published with an open source license. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Stationary chest tomosynthesis using a carbon nanotube x-ray source array: a feasibility study

    International Nuclear Information System (INIS)

    Shan, Jing; Lee, Yueh Z; Lu, Jianping; Zhou, Otto; Tucker, Andrew W; Heath, Michael D; Wang, Xiaohui; Foos, David H

    2015-01-01

    Chest tomosynthesis is a low-dose, quasi-3D imaging modality that has been demonstrated to improve the detection sensitivity for small lung nodules, compared to 2D chest radiography. The purpose of this study is to investigate the feasibility and system requirements of stationary chest tomosynthesis (s-DCT) using a spatially distributed carbon nanotube (CNT) x-ray source array, where the projection images are collected by electronically activating individual x-ray focal spots in the source array without mechanical motion of the x-ray source, detector, or the patient. A bench-top system was constructed using an existing CNT field emission source array and a flat panel detector. The tube output, beam quality, focal spot size, system in-plane and in-depth resolution were characterized. Tomosynthesis slices of an anthropomorphic chest phantom were reconstructed for image quality assessment. All 75 CNT sources in the source array were shown to operate reliably at 80 kVp and 5 mA tube current. Source-to-source consistency in the tube current and focal spot size was observed. The incident air kerma reading per mAs was measured as 74.47 uGy mAs −1 at 100 cm. The first half value layer of the beam was 3 mm aluminum. An average focal spot size of 2.5  ×  0.5 mm was measured. The system MTF was measured to be 1.7 cycles mm −1 along the scanning direction, and 3.4 cycles mm −1 perpendicular to the scanning direction. As the angular coverage of 11.6°–34°, the full width at half maximum of the artifact spread function improved greatly from 9.5 to 5.2 mm. The reconstructed tomosynthesis slices clearly show airways and pulmonary vascular structures in the anthropomorphic lung phantom. The results show the CNT source array is capable of generating sufficient dose for chest tomosynthesis imaging. The results obtained so far suggest an s-DCT using a distributed CNT x-ray source array is feasible. (paper)

  1. Ion beam production and study of radioactive isotopes with the laser ion source at ISOLDE

    Science.gov (United States)

    Fedosseev, Valentin; Chrysalidis, Katerina; Day Goodacre, Thomas; Marsh, Bruce; Rothe, Sebastian; Seiffert, Christoph; Wendt, Klaus

    2017-08-01

    At ISOLDE the majority of radioactive ion beams are produced using the resonance ionization laser ion source (RILIS). This ion source is based on resonant excitation of atomic transitions by wavelength tunable laser radiation. Since its installation at the ISOLDE facility in 1994, the RILIS laser setup has been developed into a versatile remotely operated laser system comprising state-of-the-art solid state and dye lasers capable of generating multiple high quality laser beams at any wavelength in the range of 210-950 nm. A continuous programme of atomic ionization scheme development at CERN and at other laboratories has gradually increased the number of RILIS-ionized elements. At present, isotopes of 40 different elements have been selectively laser-ionized by the ISOLDE RILIS. Studies related to the optimization of the laser-atom interaction environment have yielded new laser ion source types: the laser ion source and trap and the versatile arc discharge and laser ion source. Depending on the specific experimental requirements for beam purity or versatility to switch between different ionization mechanisms, these may offer a favourable alternative to the standard hot metal cavity configuration. In addition to its main purpose of ion beam production, the RILIS is used for laser spectroscopy of radioisotopes. In an ongoing experimental campaign the isotope shifts and hyperfine structure of long isotopic chains have been measured by the extremely sensitive in-source laser spectroscopy method. The studies performed in the lead region were focused on nuclear deformation and shape coexistence effects around the closed proton shell Z = 82. The paper describes the functional principles of the RILIS, the current status of the laser system and demonstrated capabilities for the production of different ion beams including the high-resolution studies of short-lived isotopes and other applications of RILIS lasers for ISOLDE experiments. This article belongs to the Focus on

  2. The Internet as a Source of Academic Research Information: Findings of Two Pilot Studies.

    Science.gov (United States)

    Kibirige, Harry M.; DePalo, Lisa

    2000-01-01

    Discussion of information available on the Internet focuses on two pilot studies that investigated how academic users perceive search engines and subject-oriented databases as sources of topical information. Highlights include information seeking behavior of academic users; undergraduate users; graduate users; faculty; and implications for…

  3. Do knowledge, knowledge sources and reasoning skills affect the accuracy of nursing diagnoses? a randomised study

    NARCIS (Netherlands)

    Paans, W.; Sermeus, W.; Nieweg, R.M.; Krijnen, W.P.; van der Schans, C.P.

    2012-01-01

    ABSTRACT: BACKGROUND: This paper reports a study about the effect of knowledge sources, such as handbooks, an assessment format and a predefined record structure for diagnostic documentation, as well as the influence of knowledge, disposition toward critical thinking and reasoning skills, on the

  4. Do knowledge, knowledge sources and reasoning skills affect the accuracy of nursing diagnoses? : a randomised study

    NARCIS (Netherlands)

    Paans, Wolter; Sermeus, Walter; Nieweg, Roos; Krijnen, Wim P.; van der Schans, Cees P.

    2012-01-01

    BACKGROUND: This paper reports a study about the effect of knowledge sources, such as handbooks, an assessment format and a predefined record structure for diagnostic documentation, as well as the influence of knowledge, disposition toward critical thinking and reasoning skills, on the accuracy of

  5. Study of the shielding for spontaneous fission sources of Californium-252

    International Nuclear Information System (INIS)

    Davila R, I.

    1991-06-01

    A shielding study is made to attenuate, until maximum permissible levels, the neutrons radiation and photons emitted by spontaneous fission coming from a source of Californium-252. The compound package by a database (Library DLC-23) and the ANISNW code is used, in it version for personal computer. (Author)

  6. Study for a 6 GeV undulator based synchrotron radiation source

    International Nuclear Information System (INIS)

    Vignola, G.; Barton, M.; Blumberg, R.; Galayda, J.; Krinsky, S.; Luccio, A.; Pellegrini, C.; van Steenbergen, A.; Wang, J.

    1985-01-01

    A partial study for a 6 GeV undulator based synchrotron radiation source for production of high brightness undulator radiation, in the A region, is presented. The basic lattice adopted for the storage ring is a hybrid FODO Chasman-Green lattice, making use of gradient in the dipoles. We discuss also the e beam current limits and the injection parameters

  7. Modelling of an experiment for the study of neutron spallation source at JINR

    International Nuclear Information System (INIS)

    Kumawat, Harphool; Goyal, Uttam; Kumar, V.; Barashenkov, V.S.

    2002-01-01

    Intense neutron spallation source (INSS) is a necessary requirement of accelerator driven sub-critical systems. INSS are proposed to be generated using the high current proton beams. Some studies are conducted for the neutron flux, transmutation rates and energy gains and a larger number of related experiments are being planned

  8. Inter-comparison of receptor models for PM source apportionment: Case study in an industrial area

    Science.gov (United States)

    Viana, M.; Pandolfi, M.; Minguillón, M. C.; Querol, X.; Alastuey, A.; Monfort, E.; Celades, I.

    2008-05-01

    Receptor modelling techniques are used to identify and quantify the contributions from emission sources to the levels and major and trace components of ambient particulate matter (PM). A wide variety of receptor models are currently available, and consequently the comparability between models should be evaluated if source apportionment data are to be used as input in health effects studies or mitigation plans. Three of the most widespread receptor models (principal component analysis, PCA; positive matrix factorization, PMF; chemical mass balance, CMB) were applied to a single PM10 data set (n=328 samples, 2002-2005) obtained from an industrial area in NE Spain, dedicated to ceramic production. Sensitivity and temporal trend analyses (using the Mann-Kendall test) were applied. Results evidenced the good overall performance of the three models (r2>0.83 and α>0.91×between modelled and measured PM10 mass), with a good agreement regarding source identification and high correlations between input (CMB) and output (PCA, PMF) source profiles. Larger differences were obtained regarding the quantification of source contributions (up to a factor of 4 in some cases). The combined application of different types of receptor models would solve the limitations of each of the models, by constructing a more robust solution based on their strengths. The authors suggest the combined use of factor analysis techniques (PCA, PMF) to identify and interpret emission sources, and to obtain a first quantification of their contributions to the PM mass, and the subsequent application of CMB. Further research is needed to ensure that source apportionment methods are robust enough for application to PM health effects assessments.

  9. Studies in High Current Density Ion Sources for Heavy Ion Fusion Applications

    International Nuclear Information System (INIS)

    Chacon-Golcher, E.

    2002-01-01

    This dissertation develops diverse research on small (diameter ∼ few mm), high current density (J ∼ several tens of mA/cm 2 ) heavy ion sources. The research has been developed in the context of a programmatic interest within the Heavy Ion Fusion (HIF) Program to explore alternative architectures in the beam injection systems that use the merging of small, bright beams. An ion gun was designed and built for these experiments. Results of average current density yield ( ) at different operating conditions are presented for K + and Cs + contact ionization sources and potassium aluminum silicate sources. Maximum values for a K + beam of ∼90 mA/cm 2 were observed in 2.3 (micro)s pulses. Measurements of beam intensity profiles and emittances are included. Measurements of neutral particle desorption are presented at different operating conditions which lead to a better understanding of the underlying atomic diffusion processes that determine the lifetime of the emitter. Estimates of diffusion times consistent with measurements are presented, as well as estimates of maximum repetition rates achievable. Diverse studies performed on the composition and preparation of alkali aluminosilicate ion sources are also presented. In addition, this work includes preliminary work carried out exploring the viability of an argon plasma ion source and a bismuth metal vapor vacuum arc (MEVVA) ion source. For the former ion source, fast rise-times (∼ 1 (micro)s), high current densities (∼ 100 mA/cm 2 ) and low operating pressures ( e psilon) n (le) 0.006 π mm · mrad) although measured currents differed from the desired ones (I ∼ 5mA) by about a factor of 10

  10. Studies in High Current Density Ion Sources for Heavy Ion Fusion Applications

    Energy Technology Data Exchange (ETDEWEB)

    Chacon-Golcher, Edwin [Univ. of California, Berkeley, CA (United States)

    2002-06-01

    This dissertation develops diverse research on small (diameter ~ few mm), high current density (J ~ several tens of mA/cm2) heavy ion sources. The research has been developed in the context of a programmatic interest within the Heavy Ion Fusion (HIF) Program to explore alternative architectures in the beam injection systems that use the merging of small, bright beams. An ion gun was designed and built for these experiments. Results of average current density yield () at different operating conditions are presented for K+ and Cs+ contact ionization sources and potassium aluminum silicate sources. Maximum values for a K+ beam of ~90 mA/cm2 were observed in 2.3 μs pulses. Measurements of beam intensity profiles and emittances are included. Measurements of neutral particle desorption are presented at different operating conditions which lead to a better understanding of the underlying atomic diffusion processes that determine the lifetime of the emitter. Estimates of diffusion times consistent with measurements are presented, as well as estimates of maximum repetition rates achievable. Diverse studies performed on the composition and preparation of alkali aluminosilicate ion sources are also presented. In addition, this work includes preliminary work carried out exploring the viability of an argon plasma ion source and a bismuth metal vapor vacuum arc (MEVVA) ion source. For the former ion source, fast rise-times (~ 1 μs), high current densities (~ 100 mA/cm+) and low operating pressures (< 2 mtorr) were verified. For the latter, high but acceptable levels of beam emittance were measured (εn ≤ 0.006 π· mm · mrad) although measured currents differed from the desired ones (I ~ 5mA) by about a factor of 10.

  11. Source identification of ambient PM2.5 during summer inhalation exposure studies in Detroit, MI

    Energy Technology Data Exchange (ETDEWEB)

    Morishita, M.; Keeler, G.J.; Wagner, J.G.; Harkema, J.R. [University of Michigan, Ann Arbor, MI (United States). Air Quality Laboratory

    2006-07-15

    Particulate air pollution is associated with cardiopulmonary morbidity and mortality in heavily populated urban centers of the United States. Because ambient fine particulate matter (aerodynamic diameter {<=} 2.5 {mu}m; PM2.5) is a complex mixture resulting from multiple sources and variable atmospheric conditions, it is difficult to identify specific components of PM2.5 that are responsible for adverse health effects. During four consecutive summers from 2000 to 2003 we characterized the ambient gaseous and PM2.5 air quality in an urban southwest Detroit community where childhood asthma hospitalization rates are more than twice the statewide average. Both integrated and continuous PM measurements together with gaseous air pollution measurements were performed using a mobile air research facility, AirCARE1, in which concurrent toxicological studies were being conducted. Chemical and physical characterizations of PM2.5 as well as receptor modeling using positive matrix factorization (PMF) were completed. Results from PMF indicated that six major sources contributed to the observed ambient PM2.5 mass during the summer months. Primary sources included (1) coal combustion/secondary sulfate aerosol, (2) motor vehicle/urban road dust, (3) municipal waste incinerators, (4) oil combustion/refineries, (5) sewage sludge incinerators, and (6) iron/steel manufacturing. Although the contribution of the coal/secondary sulfate aerosol source was greater than other factors, increased levels of urban PM2.5 from local combustion sources were also observed. In addition to characterization of ambient PM2.5 and their sources in southwest Detroit, this paper discusses possible associations of ambient PM2.5 from local combustion sources, specifically incinerator and refinery emissions and the observed adverse health effects during the inhalation exposure campaigns.

  12. Implant breast reconstruction after salvage mastectomy in previously irradiated patients.

    Science.gov (United States)

    Persichetti, Paolo; Cagli, Barbara; Simone, Pierfranco; Cogliandro, Annalisa; Fortunato, Lucio; Altomare, Vittorio; Trodella, Lucio

    2009-04-01

    The most common surgical approach in case of local tumor recurrence after quadrantectomy and radiotherapy is salvage mastectomy. Breast reconstruction is the subsequent phase of the treatment and the plastic surgeon has to operate on previously irradiated and manipulated tissues. The medical literature highlights that breast reconstruction with tissue expanders is not a pursuable option, considering previous radiotherapy a contraindication. The purpose of this retrospective study is to evaluate the influence of previous radiotherapy on 2-stage breast reconstruction (tissue expander/implant). Only patients with analogous timing of radiation therapy and the same demolitive and reconstructive procedures were recruited. The results of this study prove that, after salvage mastectomy in previously irradiated patients, implant reconstruction is still possible. Further comparative studies are, of course, advisable to draw any conclusion on the possibility to perform implant reconstruction in previously irradiated patients.

  13. Study and Analysis of an Intelligent Microgrid Energy Management Solution with Distributed Energy Sources

    Directory of Open Access Journals (Sweden)

    Swaminathan Ganesan

    2017-09-01

    Full Text Available In this paper, a robust energy management solution which will facilitate the optimum and economic control of energy flows throughout a microgrid network is proposed. The increased penetration of renewable energy sources is highly intermittent in nature; the proposed solution demonstrates highly efficient energy management. This study enables precise management of power flows by forecasting of renewable energy generation, estimating the availability of energy at storage batteries, and invoking the appropriate mode of operation, based on the load demand to achieve efficient and economic operation. The predefined mode of operation is derived out of an expert rule set and schedules the load and distributed energy sources along with utility grid.

  14. Study on a negative hydrogen ion source with hot cathode arc discharge.

    Science.gov (United States)

    Lin, S H; Fang, X; Zhang, H J; Qian, C; Ma, B H; Wang, H; Li, X X; Zhang, X Z; Sun, L T; Zhang, Z M; Yuan, P; Zhao, H W

    2014-02-01

    A negative hydrogen (H(-)) ion source with hot cathode arc discharge was designed and fabricated as a primary injector for a 10 MeV PET cyclotron at IMP. 1 mA dc H(-) beam with ɛ N, RMS = 0.08 π mm mrad was extracted at 25 kV. Halbach hexapole was adopted to confine the plasma. The state of arc discharge, the parameters including filament current, arc current, gas pressure, plasma electrode bias, and the ratio of I(e(-))/I(H(-)) were experimentally studied. The discussion on the result, and opinions to improve the source were given.

  15. Prospects of Source-Separation-Based Sanitation Concepts: A Model-Based Study

    Directory of Open Access Journals (Sweden)

    Cees Buisman

    2013-07-01

    Full Text Available Separation of different domestic wastewater streams and targeted on-site treatment for resource recovery has been recognized as one of the most promising sanitation concepts to re-establish the balance in carbon, nutrient and water cycles. In this study a model was developed based on literature data to compare energy and water balance, nutrient recovery, chemical use, effluent quality and land area requirement in four different sanitation concepts: (1 centralized; (2 centralized with source-separation of urine; (3 source-separation of black water, kitchen refuse and grey water; and (4 source-separation of urine, feces, kitchen refuse and grey water. The highest primary energy consumption of 914 MJ/capita(cap/year was attained within the centralized sanitation concept, and the lowest primary energy consumption of 437 MJ/cap/year was attained within source-separation of urine, feces, kitchen refuse and grey water. Grey water bio-flocculation and subsequent grey water sludge co-digestion decreased the primary energy consumption, but was not energetically favorable to couple with grey water effluent reuse. Source-separation of urine improved the energy balance, nutrient recovery and effluent quality, but required larger land area and higher chemical use in the centralized concept.

  16. Exploiting heterogeneous publicly available data sources for drug safety surveillance: computational framework and case studies.

    Science.gov (United States)

    Koutkias, Vassilis G; Lillo-Le Louët, Agnès; Jaulent, Marie-Christine

    2017-02-01

    Driven by the need of pharmacovigilance centres and companies to routinely collect and review all available data about adverse drug reactions (ADRs) and adverse events of interest, we introduce and validate a computational framework exploiting dominant as well as emerging publicly available data sources for drug safety surveillance. Our approach relies on appropriate query formulation for data acquisition and subsequent filtering, transformation and joint visualization of the obtained data. We acquired data from the FDA Adverse Event Reporting System (FAERS), PubMed and Twitter. In order to assess the validity and the robustness of the approach, we elaborated on two important case studies, namely, clozapine-induced cardiomyopathy/myocarditis versus haloperidol-induced cardiomyopathy/myocarditis, and apixaban-induced cerebral hemorrhage. The analysis of the obtained data provided interesting insights (identification of potential patient and health-care professional experiences regarding ADRs in Twitter, information/arguments against an ADR existence across all sources), while illustrating the benefits (complementing data from multiple sources to strengthen/confirm evidence) and the underlying challenges (selecting search terms, data presentation) of exploiting heterogeneous information sources, thereby advocating the need for the proposed framework. This work contributes in establishing a continuous learning system for drug safety surveillance by exploiting heterogeneous publicly available data sources via appropriate support tools.

  17. Market Orientation and Sources of Knowledge to Innovate in SMEs: A Firm Level Study

    Directory of Open Access Journals (Sweden)

    Simone Regina Didonet

    2016-10-01

    Full Text Available This work examines the relationship between the three market orientation (MO components, i.e. customer orientation, competitor orientation and inter-functional coordination, and the extension to which small and medium-sized enterprises (SMEs use different sources of knowledge to innovate. Based on a sample of 181 Chilean SMEs, a confirmatory factorial analysis (CFA was performed to analyze the relationship among constructs. The results show that the extension to which SMEs use different sources of knowledge to innovate depends on the interactions between MO components. This study addresses a gap in the literature, by linking and interrelating market orientation components to the innovation perspective in SMEs. Therefore, we provide insights into the role of each MO component in influencing the extension to which firms seek for and use different sources of knowledge to innovate and attempt to explain some literature inconsistencies on the theme.

  18. Preliminary design study of an alternate heat source assembly for a Brayton isotope power system

    Science.gov (United States)

    Strumpf, H. J.

    1978-01-01

    Results are presented for a study of the preliminary design of an alternate heat source assembly (HSA) intended for use in the Brayton isotope power system (BIPS). The BIPS converts thermal energy emitted by a radioactive heat source into electrical energy by means of a closed Brayton cycle. A heat source heat exchanger configuration was selected and optimized. The design consists of a 10 turn helically wound Hastelloy X tube. Thermal analyses were performed for various operating conditions to ensure that post impact containment shell (PICS) temperatures remain within specified limits. These limits are essentially satisfied for all modes of operation except for the emergency cooling system for which the PICS temperatures are too high. Neon was found to be the best choice for a fill gas for auxiliary cooling system operation. Low cycle fatigue life, natural frequency, and dynamic loading requirements can be met with minor modifications to the existing HSA.

  19. Case studies using the United States Coast Guard's Oil Identification System for petroleum spill source identification

    International Nuclear Information System (INIS)

    Grosser, P.W.; Castellano, F.P.

    1993-01-01

    The Oil Identification System (OIS) was developed in the 1970's at the Coast Guard Research and Development Center, to determine the unique, intrinsic properties which would allow the matching of a spilled oil with its correct source. The Central Oil Identification Laboratory (COIL) was established in 1978 as the operating facility to implement the OIS. The OIS encompasses four analytical methods; thin layer chromatography, fluorescence spectroscopy, infrared spectroscopy and gas chromatography. A sample can be studied according to each individual method or multi-methods approach can be chosen if no single technique gives unequivocal results. Combined these methods are greater than 99% effective. The authors recently utilized the OIS and the COIL for three petroleum spill investigations in New York. As part of the investigation to determine the source(s) of several different petroleum product spills, OIS was conducted along with a review of groundwater sample chromatograms

  20. Studies on the preparation of 103Pd inner core of seed sources for brachytherapy applications

    International Nuclear Information System (INIS)

    Saha, Sujata; Manolkar, R.B.; Vimalnath, K.V.; Dash, A.; Venkatesh, Meera

    2007-01-01

    103 Pd seed sources are used widely world over for brachytherapy applications. 103 Pd available in-house was used to study its deposition on silver wire using electro-deposition and electroless deposition techniques with an aim to developing the inner core preparation of sealed radiation sources for treatment of prostate and ocular melanoma. Various parameters such as radioactive concentration of the feed solution, current density, time, temperature and pH of the solution were optimized to achieve maximum 103 Pd deposition on Ag wire. In electroless technique, the deposited amount of Pd was found to be nearly triple compared to electro-deposition in two hours time period. Both the methods gave nonleachable and well adherent sources. (author)

  1. Rate-capability study for a four-gap phenolic RPC with a Cs-137 source

    CERN Document Server

    Lee, Kyong Sei

    2014-01-01

    We report test results of a prototype four-gap phenolic resistive plate chamber (RPC) with high-rate gamma rays irradiated from a 200-mCi 137Cs source. The detector signals of the prototype four-gap RPC were digitized at charge thresholds of 80, 130, and 170 fC by using a 32-channel front-end-electronics board, previously developed for the current double-gap RPCs in CMS. We confirmed from the test that the cosmic muons were reliably measured with efficiencies higher than 95pct up to a gamma-background rate of 5.3 kHz cm-2. We concluded from the present R and D that use of the current four-gap phenolic RPCs is advantageous to the high-η triggers in CMS in virtue of the high rate capability.

  2. Studies of an inductively coupled negative hydrogen ion radio frequency source through simulations and experiments

    International Nuclear Information System (INIS)

    Bandyopadhyay, M.

    2004-01-01

    In the frame work of a development project for ITER neutral beam injection system a radio frequency (RF) driven negative hydrogen (H-/D-) ion source, (BATMAN ion source) is developed which is designed to produce several 10s of ampere of H-/D- beam current. This PhD work has been carried out to understand and optimize BATMAN ion source. The study has been done with the help of computer simulations, modeling and experiments. The complete three dimensional Monte-Carlo computer simulation codes have been developed under the scope of this PhD work. A comprehensive description about the volume production and the surface production of H- ions is presented in the thesis along with the study results obtained from the simulations, modeling and the experiments. One of the simulations is based on the volume production of H- ions, where it calculates the density profile of the vibrationally excited H2 molecules, the density profile of H- ions and the transport probability of those H- ions along the source axis towards the grid. The other simulation studies the transport of those H- ions which are produced on the surface of the plasma grid. It is expected that if there is a plasma flow in the source, the transport of plasma components (molecules and ions) would be influenced. Experimentally it is observed that there is a convective plasma flow exists in the ion source. A transverse magnetic filter field which is present near the grid inside the ion source reduces the flow velocity. Negative ions and electrons have the same sign of charge; therefore the electrons are co-extracted with the negative ions through the grid system, which is not desirable. It is observed that a magnetic field near the grid, magnetized the electrons and therefore reduce the co-extracted electron current. It is also observed experimentally that if the plasma grid is biased positively with respect to the source body, the electron density near the plasma grid is reduced and therefore the co

  3. Comparative study of microcontroller controlled four-wire voltage and current source shunt active power filters

    Energy Technology Data Exchange (ETDEWEB)

    Pettersson, S.

    2009-07-01

    During the past two decades, active power filters have increasingly grown their popularity as a viable method for improving electric power quality. The main reasons for this have been the advent of fast self-commutating solid-state devices, the progression of digital technology and the improved sensor technology. Four-wire active power filters provide an efficient solution for improving the quality of supply in grounded three-phase systems or three-phase systems with neutral conductors, which are commonly used for powering residential, office and public buildings. Four-wire active power filters are applicable in compensating current harmonics, reactive power, neutral current and load phase imbalance.This thesis presents a comparative study of microcontroller controlled four-wire voltage and current source shunt active power filters. The study includes two voltage source topologies and a current source topology with two different dc-link energy storage structures, which are compared on the basis of their filtering properties, filtering performance and efficiency. The obtained results are used for determining the suitability of current source technology for four-wire active power filtering and finding the most viable four-wire shunt active power filter topology. One commonly recognized disadvantage of the current source active power filter has always been the bulky dc-link inductor. To reduce the size of the dc-link inductor, an alternative dc-link structure for current source active power filters was introduced in the late 80's. The hybrid energy storage consists of both inductive and capacitive energy storage elements, two diodes and two controllable semiconductor switching devices. Since the capacitive element is used as a main storage unit, the inductance of the dc-link inductor can be considerably reduced. However, the original dc current control method proposed is not able to utilize the full potential of the hybrid energy storage and the inductance

  4. Influence of the physico-chemical process as previous treatment to the electrocoagulation. Study with leachate of a landfill; Influencia del proceso fisicoquimico como tratamiento previo a la electrocoagulacion. Estudio con lixiviados de un relleno

    Energy Technology Data Exchange (ETDEWEB)

    Mercado Martinez, I. D.; Reyes Avila, D.

    2007-07-01

    This article has as purpose to show the influence of the method physico-chemical as previous process to the novel technique of electrocoagulation, presenting as a new alternative to depurate wastewaters. to obtain it, was done tests measuring the very parameters to leachates so much affluent as effluent from treatment plant of the Sanitary Landfill La Esmeralda, situated near to the Manizales city(Colombia), and so much before as later to apply this electrochemical technology, looking for this way to compare the obtained removals. (Author)

  5. Previous experience in manned space flight: A survey of human factors lessons learned

    Science.gov (United States)

    Chandlee, George O.; Woolford, Barbara

    1993-01-01

    Previous experience in manned space flight programs can be used to compile a data base of human factors lessons learned for the purpose of developing aids in the future design of inhabited spacecraft. The objectives are to gather information available from relevant sources, to develop a taxonomy of human factors data, and to produce a data base that can be used in the future for those people involved in the design of manned spacecraft operations. A study is currently underway at the Johnson Space Center with the objective of compiling, classifying, and summarizing relevant human factors data bearing on the lessons learned from previous manned space flights. The research reported defines sources of data, methods for collection, and proposes a classification for human factors data that may be a model for other human factors disciplines.

  6. Studies on the Extraction Region of the Type VI RF Driven H- Ion Source

    Science.gov (United States)

    McNeely, P.; Bandyopadhyay, M.; Franzen, P.; Heinemann, B.; Hu, C.; Kraus, W.; Riedl, R.; Speth, E.; Wilhelm, R.

    2002-11-01

    IPP Garching has spent several years developing a RF driven H- ion source intended to be an alternative to the current ITER (International Thermonuclear Experimental Reactor) reference design ion source. A RF driven source offers a number of advantages to ITER in terms of reduced costs and maintenance requirements. Although the RF driven ion source has shown itself to be competitive with a standard arc filament ion source for positive ions many questions still remain on the physics behind the production of the H- ion beam extracted from the source. With the improvements that have been implemented to the BATMAN (Bavarian Test Machine for Negative Ions) facility over the last two years it is now possible to study both the extracted ion beam and the plasma in the vicinity of the extraction grid in greater detail. This paper will show the effect of changing the extraction and acceleration voltage on both the current and shape of the beam as measured on the calorimeter some 1.5 m downstream from the source. The extraction voltage required to operate in the plasma limit is 3 kV. The perveance optimum for the extraction system was determined to be 2.2 x 10-6 A/V3/2 and occurs at 2.7 kV extraction voltage. The horizontal and vertical beam half widths vary as a function of the extracted ion current and the horizontal half width is generally smaller than the vertical. The effect of reducing the co-extracted electron current via plasma grid biasing on the H- current extractable and the beam profile from the source is shown. It is possible in the case of a silver contaminated plasma to reduce the co-extracted electron current to 20% of the initial value by applying a bias of 12 V. In the case where argon is present in the plasma, biasing is observed to have minimal effect on the beam half width but in a pure hydrogen plasma the beam half width increases as the bias voltage increases. New Langmuir probe studies that have been carried out parallel to the plasma grid (in the

  7. A novel low cost pulse excitation source to study trap spectroscopy of persistent luminescent materials

    Science.gov (United States)

    Chandrasekhar, Ngangbam; Singh, Nungleppam Monorajan; Gartia, R. K.

    2018-04-01

    Luminescent techniques require one or the other source of excitations which may vary from high cost X-rays, γ-rays, β-rays etc. to low cost LED. Persistent luminescent materials or Glow-in-the-Dark phosphors are the optical harvesters which store the optical energy from day light illuminating a whole night. They are so sensitive that they can be excited even with the low light of firefly. Therefore, instead of using a high cost excitation source authors have developed a low cost functioning of excitation source controlling short pulses of LED to excite persistent phosphors with the aid of ExpEYES Junior (Hardware/software framework developed by IUAC, New Delhi). Using this, the authors have excited the sample under investigation upto 10 ms. Trap spectroscopy of the pre-excited sample with LED is studied using Thermoluminescence (TL) technique. In this communication, development of the excitation source is discussed and demonstrate the its usefulness in the study of trap spectroscopy of commercially available CaS:Eu2+, Sm3+. Trapping parameters are also evaluated using Computerized Glow Curve Deconvolution (CGCD) technique.

  8. Multiband Study of Radio Sources of the RCR Catalogue with Virtual Observatory Tools

    Directory of Open Access Journals (Sweden)

    Zhelenkova O. P.

    2012-09-01

    Full Text Available We present early results of our multiband study of the RATAN Cold Revised (RCR catalogue obtained from seven cycles of the “Cold” survey carried with the RATAN-600 radio telescope at 7.6 cm in 1980-1999, at the declination of the SS 433 source. We used the 2MASS and LAS UKIDSS infrared surveys, the DSS-II and SDSS DR7 optical surveys, as well as the USNO-B1 and GSC-II catalogues, the VLSS, TXS, NVSS, FIRST and GB6 radio surveys to accumulate information about the sources. For radio sources that have no detectable optical candidate in optical or infrared catalogues, we additionally looked through images in several bands from the SDSS, LAS UKIDSS, DPOSS, 2MASS surveys and also used co-added frames in different bands. We reliably identified 76% of radio sources of the RCR catalogue. We used the ALADIN and SAOImage DS9 scripting capabilities, interoperability services of ALADIN and TOPCAT, and also other Virtual Observatory (VO tools and resources, such as CASJobs, NED, Vizier, and WSA, for effective data access, visualization and analysis. Without VO tools it would have been problematic to perform our study.

  9. Text mining and visualization case studies using open-source tools

    CERN Document Server

    Chisholm, Andrew

    2016-01-01

    Text Mining and Visualization: Case Studies Using Open-Source Tools provides an introduction to text mining using some of the most popular and powerful open-source tools: KNIME, RapidMiner, Weka, R, and Python. The contributors-all highly experienced with text mining and open-source software-explain how text data are gathered and processed from a wide variety of sources, including books, server access logs, websites, social media sites, and message boards. Each chapter presents a case study that you can follow as part of a step-by-step, reproducible example. You can also easily apply and extend the techniques to other problems. All the examples are available on a supplementary website. The book shows you how to exploit your text data, offering successful application examples and blueprints for you to tackle your text mining tasks and benefit from open and freely available tools. It gets you up to date on the latest and most powerful tools, the data mining process, and specific text mining activities.

  10. Study of principle error sources in gamma spectrometry. Application to cross sections measurement

    International Nuclear Information System (INIS)

    Majah, M. Ibn.

    1985-01-01

    The principle error sources in gamma spectrometry have been studied in purpose to measure cross sections with great precision. Three error sources have been studied: dead time and pile up which depend on counting rate, and coincidence effect that depends on the disintegration scheme of the radionuclide in question. A constant frequency pulse generator has been used to correct the counting loss due to dead time and pile up in cases of long and short disintegration periods. The loss due to coincidence effect can reach 25% and over, depending on the disintegration scheme and on the distance source-detector. After establishing the correction formula and verifying its validity for four examples: iron 56, scandium 48, antimony 120 and gold 196 m, an application has been done by measuring cross sections of nuclear reactions that lead to long disintegration periods which need short distance source-detector counting and thus correcting the loss due to dead time effect, pile up and coincidence effect. 16 refs., 45 figs., 25 tabs. (author)

  11. Use of multiple data sources to estimate hepatitis C seroprevalence among prisoners: A retrospective cohort study.

    Directory of Open Access Journals (Sweden)

    Kathryn J Snow

    Full Text Available Hepatitis C is a major cause of preventable morbidity and mortality. Prisoners are a key population for hepatitis C control programs, and with the advent of highly effective therapies, prisons are increasingly important sites for hepatitis C diagnosis and treatment. Accurate estimates of hepatitis C prevalence among prisoners are needed in order to plan and resource service provision, however many prevalence estimates are based on surveys compromised by limited and potentially biased participation. We aimed to compare estimates derived from three different data sources, and to assess whether the use of self-report as a supplementary data source may help researchers assess the risk of selection bias. We used three data sources to estimate the prevalence of hepatitis C antibodies in a large cohort of Australian prisoners-prison medical records, self-reported status during a face-to-face interview prior to release from prison, and data from a statewide notifiable conditions surveillance system. Of 1,315 participants, 33.8% had at least one indicator of hepatitis C seropositivity, however less than one third of these (9.5% of the entire cohort were identified by all three data sources. Among participants of known status, self-report had a sensitivity of 80.1% and a positive predictive value of 97.8%. Any one data source used in isolation would have under-estimated the prevalence of hepatitis C in this cohort. Using multiple data sources in studies of hepatitis C seroprevalence among prisoners may improve case detection and help researchers assess the risk of selection bias due to non-participation in serological testing.

  12. Hydrocarbon source apportionment for the 1996 Paso del Norte Ozone Study.

    Science.gov (United States)

    Fujita, E M

    2001-08-10

    The 1996 Paso del Norte (PdN) ozone study was conducted to improve current understanding of the significant meteorological and air quality processes that lead to high concentrations of ozone in El Paso, Texas (USA) and Ciudad Juárez, Chihuahua (Mexico). Two-hour canister samples were collected five times daily at 05.00-07.00 h, 07.00-09.00 h, 09.00-11.00 h, 11.00-13.00 h, and 15.00-17.00 h MST during intensive study periods at one urban and one rural site on each side of the border. An automated gas chromatograph was operated at one site in central El Paso. Source profiles (the fractional chemical composition of emissions) from motor vehicles, gasoline, liquefied petroleum gas, and commercial natural gas were combined with source profiles from other studies for input to the Chemical Mass Balance (CMB) receptor model to apportion the measured non-methane hydrocarbons (NMHC) to sources. On-road vehicle emissions accounted for one-half to two-thirds of the NMHC in Ciudad Juárez and El Paso with the highest contributions occurring during the morning and afternoon commute periods. Emissions from diesel exhaust contributed approximately 2-3% of NMHC in Ciudad Juárez and less than 2% in El Paso. The average sum of liquid gasoline and gasoline vapor increased during the day in Ciudad Juárez from 2% at 06.00 h to approximately 12% at 16.00 h. Diurnal and day-of-the-week patterns in the liquid gasoline contributions are essentially identical to the corresponding patterns for motor vehicle exhaust, which suggest that a large fraction of the liquid gasoline contribution may be associated with tailpipe emissions rather than evaporative emissions from motor vehicles or industrial sources. Including the sum of the two sources put the upper limit for tailpipe contributions at 60-70% of NMHC.

  13. Hydrocarbon source apportionment for the 1996 Paso del Norte Ozone Study

    Energy Technology Data Exchange (ETDEWEB)

    Fujita, E.M. [Desert Research Institute, 2215 Raggio Parkway, Reno, NV 89506-0220 (United States)

    2001-08-10

    The 1996 Paso del Norte (PdN) ozone study was conducted to improve current understanding of the significant meteorological and air quality processes that lead to high concentrations of ozone in El Paso, Texas (USA) and Ciudad Juarez, Chihuahua (Mexico). Two-hour canister samples were collected five times daily at 05.00-07.00 h, 07.00-09.00 h, 09.00-11.00 h, 11.00-13.00 h, and 15.00-17.00 h MST during intensive study periods at one urban and one rural site on each side of the border. An automated gas chromatograph was operated at one site in central El Paso. Source profiles (the fractional chemical composition of emissions) from motor vehicles, gasoline, liquefied petroleum gas, and commercial natural gas were combined with source profiles from other studies for input to the Chemical Mass Balance (CMB) receptor model to apportion the measured non-methane hydrocarbons (NMHC) to sources. On-road vehicle emissions accounted for one-half to two-thirds of the NMHC in Ciudad Juarez and El Paso with the highest contributions occurring during the morning and afternoon commute periods. Emissions from diesel exhaust contributed approximately 2-3% of NMHC in Ciudad Juarez and less than 2% in El Paso. The average sum of liquid gasoline and gasoline vapor increased during the day in Ciudad Juarez from 2% at 06.00 h to approximately 12% at 16.00 h. Diurnal and day-of-the-week patterns in the liquid gasoline contributions are essentially identical to the corresponding patterns for motor vehicle exhaust, which suggest that a large fraction of the liquid gasoline contribution may be associated with tailpipe emissions rather than evaporative emissions from motor vehicles or industrial sources. Including the sum of the two sources put the upper limit for tailpipe contributions at 60-70% of NMHC.

  14. Effect of conductor geometry on source localization: Implications for epilepsy studies

    International Nuclear Information System (INIS)

    Schlitt, H.; Heller, L.; Best, E.; Ranken, D.; Aaron, R.

    1994-01-01

    We shall discuss the effects of conductor geometry on source localization for applications in epilepsy studies. The most popular conductor model for clinical MEG studies is a homogeneous sphere. However, several studies have indicated that a sphere is a poor model for the head when the sources are deep, as is the case for epileptic foci in the mesial temporal lobe. We believe that replacing the spherical model with a more realistic one in the inverse fitting procedure will improve the accuracy of localizing epileptic sources. In order to include a realistic head model in the inverse problem, we must first solve the forward problem for the realistic conductor geometry. We create a conductor geometry model from MR images, and then solve the forward problem via a boundary integral equation for the electric potential due to a specified primary source. One the electric potential is known, the magnetic field can be calculated directly. The most time-intensive part of the problem is generating the conductor model; fortunately, this needs to be done only once for each patient. It takes little time to change the primary current and calculate a new magnetic field for use in the inverse fitting procedure. We present the results of a series of computer simulations in which we investigate the localization accuracy due to replacing the spherical model with the realistic head model in the inverse fitting procedure. The data to be fit consist of a computer generated magnetic field due to a known current dipole in a realistic head model, with added noise. We compare the localization errors when this field is fit using a spherical model to the fit using a realistic head model. Using a spherical model is comparable to what is usually done when localizing epileptic sources in humans, where the conductor model used in the inverse fitting procedure does not correspond to the actual head

  15. Studies on {sup 63}Ni based check-light sources for TL readers

    Energy Technology Data Exchange (ETDEWEB)

    Nagpal, J.S.; Venkataraman, G. [Bhabha Atomic Research Centre, Bombay (India). Radiation Protection Services Div.; Udhayakyumar, J. [Bhabha Atomic Research Centre, Bombay (India). Board of Radiation and Isotope Technology; Page, A.G. [Bhabha Atomic Research Centre, Bombay (India). Radiochemistry Div.

    1995-12-31

    The performance of indigenously produced, electrodeposited {sup 63}Ni sources having 10 mm x 10 mm active area and individually coupled to a plastic scintillator has been studied. TL phosphors such as CaF{sub 2}, CaF{sub 2}:Dy, CaF{sub 2}:Tm, CaF{sub 2}:Eu, TLD-100 and CaSO{sub 4}:Dy with {sup 63}Ni have been studied for their possible use as check-light sources for testing TL readers. Stability at ambient temperatures (298-323 K), build-up and decrease of light output with time have been examined. A preliminary study of the fluorescent species in the gamma irradiated plastic scintillator has been made. (author).

  16. Noise disturbance in open-plan study environments: a field study on noise sources, student tasks and room acoustic parameters.

    Science.gov (United States)

    Braat-Eggen, P Ella; van Heijst, Anne; Hornikx, Maarten; Kohlrausch, Armin

    2017-09-01

    The aim of this study is to gain more insight in the assessment of noise in open-plan study environments and to reveal correlations between noise disturbance experienced by students and the noise sources they perceive, the tasks they perform and the acoustic parameters of the open-plan study environment they work in. Data were collected in five open-plan study environments at universities in the Netherlands. A questionnaire was used to investigate student tasks, perceived sound sources and their perceived disturbance, and sound measurements were performed to determine the room acoustic parameters. This study shows that 38% of the surveyed students are disturbed by background noise in an open-plan study environment. Students are mostly disturbed by speech when performing complex cognitive tasks like studying for an exam, reading and writing. Significant but weak correlations were found between the room acoustic parameters and noise disturbance of students. Practitioner Summary: A field study was conducted to gain more insight in the assessment of noise in open-plan study environments at universities in the Netherlands. More than one third of the students was disturbed by noise. An interaction effect was found for task type, source type and room acoustic parameters.

  17. Global sourcing risk management approaches: A study of small clothing and textile retailers in Gauteng

    Directory of Open Access Journals (Sweden)

    Wesley Niemann

    2018-02-01

    Full Text Available Background: Global sourcing has increased as buyers searched for new markets that offered better pricing, quality, variety and delivery lead times than their local markets. However, the increase in global sourcing has also exposed businesses to many supply risks. Purpose: The purpose of this descriptive qualitative study was to explore the global sourcing supply risks encountered by small clothing and textile retailers in Gauteng and to determine what supply risk identification and management approaches they utilise. Method: This study utilised semi-structured interviews conducted with 12 small clothing and textile retail owners. Results: The study found that the three major supply risks encountered by these retailers were fluctuating exchange rates, communication barriers and costly and complicated logistics, which included high customs costs. Furthermore, although aware of the supply risks, none of the small clothing and textile retailers had formal identification and management approaches in place. Instead, risks are dealt with at the sole discretion of the owner as and when they occur. The study also found that informal identification and management approaches were being applied by some of the retailers. These included factoring exchange rate fluctuations into the profit margins and using translators to combat communication barriers. Contribution: The study is one of the first empirical studies conducted on global supply risks and the associated identification and management approaches in the South African small business context, specifically focused on clothing and textile retailers. Conclusion: Small clothing and textile retailers need to proactively identify and manage global sourcing risk using the identified approaches in order to reduce and mitigate potential supply disruptions.

  18. Previous utilization of service does not improve timely booking in ...

    African Journals Online (AJOL)

    Previous utilization of service does not improve timely booking in antenatal care: Cross sectional study ... Journal Home > Vol 24, No 3 (2010) > ... Results: Past experience on antenatal care service utilization did not come out as a predictor for ...

  19. Books average previous decade of economic misery.

    Science.gov (United States)

    Bentley, R Alexander; Acerbi, Alberto; Ormerod, Paul; Lampos, Vasileios

    2014-01-01

    For the 20(th) century since the Depression, we find a strong correlation between a 'literary misery index' derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade.

  20. Books Average Previous Decade of Economic Misery

    Science.gov (United States)

    Bentley, R. Alexander; Acerbi, Alberto; Ormerod, Paul; Lampos, Vasileios

    2014-01-01

    For the 20th century since the Depression, we find a strong correlation between a ‘literary misery index’ derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade. PMID:24416159

  1. Study of cold and hot sources in a research reactor. (Physics, specifications, operation, utilization)

    International Nuclear Information System (INIS)

    Safieh, J.

    1982-10-01

    A brief description of the reactor, sources and experimental channels (ORPHEE being taken as example) is first given. The first part deals with the hot neutron source, mainly made of a graphite block to be carried at a temperature of 1500 0 K by nuclear heating. The present study focused on the determination, with the code MERCURE IV, of heat sources generated in the graphite block. From these results the spatial distribution of temperatures have been calculated with two different methods. Mechanical and thermal stresses have been calculated for the hot points. Then, the outlet neutron spectra is determined by means of the code APOLLO. Finally, the operation of the device is presented and the risks and the safety measures are given. The second part deals with cold neutron sources comprising mainly a cold moderator (liquid hydrogen 20.4 0 K). The helium coolant circuit liquefies the hydrogen by means of heat exchange in a condenser. Cold neutron yields calculations are developed by means of the code THERMOS in the plane and cyclindrical geometries. Heat sources generated by nuclear radiations are calculated. A detailed description of the device and its coolant circuit is given, and a risk analysis is finally presented. The third part deals with the part of thermal cold and hot neutrons in the study of matter and its dynamics. Technical means needed to obtain a monochromatic beam, for diffraction experiments, are recalled emphasizing on the interest of these neutrons with regard to X radiation. Then, one deals with cold neutron guides. Finally, the efficiency of two neutron guides is calculated. 78 refs [fr

  2. No discrimination against previous mates in a sexually cannibalistic spider

    Science.gov (United States)

    Fromhage, Lutz; Schneider, Jutta M.

    2005-09-01

    In several animal species, females discriminate against previous mates in subsequent mating decisions, increasing the potential for multiple paternity. In spiders, female choice may take the form of selective sexual cannibalism, which has been shown to bias paternity in favor of particular males. If cannibalistic attacks function to restrict a male's paternity, females may have little interest to remate with males having survived such an attack. We therefore studied the possibility of female discrimination against previous mates in sexually cannibalistic Argiope bruennichi, where females almost always attack their mate at the onset of copulation. We compared mating latency and copulation duration of males having experienced a previous copulation either with the same or with a different female, but found no evidence for discrimination against previous mates. However, males copulated significantly shorter when inserting into a used, compared to a previously unused, genital pore of the female.

  3. Water displacement leg volumetry in clinical studies - A discussion of error sources

    Science.gov (United States)

    2010-01-01

    Background Water displacement leg volumetry is a highly reproducible method, allowing the confirmation of efficacy of vasoactive substances. Nevertheless errors of its execution and the selection of unsuitable patients are likely to negatively affect the outcome of clinical studies in chronic venous insufficiency (CVI). Discussion Placebo controlled double-blind drug studies in CVI were searched (Cochrane Review 2005, MedLine Search until December 2007) and assessed with regard to efficacy (volume reduction of the leg), patient characteristics, and potential methodological error sources. Almost every second study reported only small drug effects (≤ 30 mL volume reduction). As the most relevant error source the conduct of volumetry was identified. Because the practical use of available equipment varies, volume differences of more than 300 mL - which is a multifold of a potential treatment effect - have been reported between consecutive measurements. Other potential error sources were insufficient patient guidance or difficulties with the transition from the Widmer CVI classification to the CEAP (Clinical Etiological Anatomical Pathophysiological) grading. Summary Patients should be properly diagnosed with CVI and selected for stable oedema and further clinical symptoms relevant for the specific study. Centres require a thorough training on the use of the volumeter and on patient guidance. Volumetry should be performed under constant conditions. The reproducibility of short term repeat measurements has to be ensured. PMID:20070899

  4. Strategic planning as a competitive differential: A case study of the Sealed Sources Production Laboratory

    International Nuclear Information System (INIS)

    Vieira, Imário; Nascimento, Fernando C.; Calvo, Wilson A. Parejo

    2017-01-01

    Strategic planning has always been and continues to be one of the most important management tools for decision making. Amidst the uncertainties of the 21"s"t century, public, private and third sector organizations are steadily struggling to improve their strategic plans by using more effective results management tools such as BSC-Balanced Scorecard. Nuclear research institutes and research centers around the world have been using more and more these types of tools in their strategic planning and management. The objective of this article was to recommend the use the BSC as a strategic tool for decision making for the Sealed Sources Production Laboratory located in the Radiation Technology Center, at Nuclear and Energy Research Institute (IPEN/CNEN-SP), in Sao Paulo, Brazil. The methodology used in this academic article was a case study, which considered the object of the study, the Sealed Sources Production Laboratory, from January 2014 to August 2016. Among the main results obtained with this study can be cited: the improvement of the information flow, the visualization and proposition to change the periodicity of analysis of the results, among others. In view of the expected results, it was possible to conclude that this study may be of value to the Sealed Sources Production Laboratory for Industrial Radiography and Industrial Process Control and also to other research centers, as it will allow and contribute with an additional management support tool. (author)

  5. Strategic planning as a competitive differential: A case study of the Sealed Sources Production Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Vieira, Imário; Nascimento, Fernando C.; Calvo, Wilson A. Parejo, E-mail: imariovieira@yahoo.com, E-mail: wapcalvo@ipen.br, E-mail: fcodelo@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Faculdade SENAI de Tecnologia Ambiental, Sao Bernardo do Campo, SP (Brazil)

    2017-11-01

    Strategic planning has always been and continues to be one of the most important management tools for decision making. Amidst the uncertainties of the 21{sup st} century, public, private and third sector organizations are steadily struggling to improve their strategic plans by using more effective results management tools such as BSC-Balanced Scorecard. Nuclear research institutes and research centers around the world have been using more and more these types of tools in their strategic planning and management. The objective of this article was to recommend the use the BSC as a strategic tool for decision making for the Sealed Sources Production Laboratory located in the Radiation Technology Center, at Nuclear and Energy Research Institute (IPEN/CNEN-SP), in Sao Paulo, Brazil. The methodology used in this academic article was a case study, which considered the object of the study, the Sealed Sources Production Laboratory, from January 2014 to August 2016. Among the main results obtained with this study can be cited: the improvement of the information flow, the visualization and proposition to change the periodicity of analysis of the results, among others. In view of the expected results, it was possible to conclude that this study may be of value to the Sealed Sources Production Laboratory for Industrial Radiography and Industrial Process Control and also to other research centers, as it will allow and contribute with an additional management support tool. (author)

  6. Sacrococcygeal pilonidal disease: analysis of previously proposed risk factors

    Directory of Open Access Journals (Sweden)

    Ali Harlak

    2010-01-01

    Full Text Available PURPOSE: Sacrococcygeal pilonidal disease is a source of one of the most common surgical problems among young adults. While male gender, obesity, occupations requiring sitting, deep natal clefts, excessive body hair, poor body hygiene and excessive sweating are described as the main risk factors for this disease, most of these need to be verified with a clinical trial. The present study aimed to evaluate the value and effect of these factors on pilonidal disease. METHOD: Previously proposed main risk factors were evaluated in a prospective case control study that included 587 patients with pilonidal disease and 2,780 healthy control patients. RESULTS: Stiffness of body hair, number of baths and time spent seated per day were the three most predictive risk factors. Adjusted odds ratios were 9.23, 6.33 and 4.03, respectively (p<0.001. With an adjusted odds ratio of 1.3 (p<.001, body mass index was another risk factor. Family history was not statistically different between the groups and there was no specific occupation associated with the disease. CONCLUSIONS: Hairy people who sit down for more than six hours a day and those who take a bath two or less times per week are at a 219-fold increased risk for sacrococcygeal pilonidal disease than those without these risk factors. For people with a great deal of hair, there is a greater need for them to clean their intergluteal sulcus. People who engage in work that requires sitting in a seat for long periods of time should choose more comfortable seats and should also try to stand whenever possible.

  7. A feasibility study of a neutrino source based on a muon storage ring

    CERN Document Server

    Finley, D

    2001-01-01

    We present the results of a study commissioned by the Fermilab Director on the feasibility of an intense neutrino source, based on a muon storage ring. Muon colliders have been discussed as an alternate route to very high-energy lepton colliders. As a by-product, such a collider would produce very intense neutrino beams because of the decaying muons circulating in the storage ring. In a dedicated storage ring, these neutrino beams could be produced in long straight sections which would point towards long, medium or short baseline detectors, opening up a whole new class of neutrino physics experiments because of the enormous neutrino flux that, in principle, could be achieved in such a facility as compared to more standard fixed target sources. Intense pion sources in combination with powerful emittance cooling strategies for the comparatively large muon emittance are necessary to make this type of neutrino source as well as a muon collider, feasible for a possible future high energy physics facility. The Neut...

  8. Hot-cavity studies for the Resonance Ionization Laser Ion Source

    International Nuclear Information System (INIS)

    Henares, J.L.; Lecesne, N.; Hijazi, L.; Bastin, B.; Kron, T.; Lassen, J.; Le Blanc, F.; Leroy, R.; Osmond, B.; Raeder, S.; Schneider, F.; Wendt, K.

    2016-01-01

    The Resonance Ionization Laser Ion Source (RILIS) has emerged as an important technique in many Radioactive Ion Beam (RIB) facilities for its reliability, and ability to ionize target elements efficiently and element selectively. GISELE is an off-line RILIS test bench to study the implementation of an on-line laser ion source at the GANIL separator facility. The aim of this project is to determine the best technical solution which combines high selectivity and ionization efficiency with small ion beam emittance and stable long term operation. The ion source geometry was tested in several configurations in order to find a solution with optimal ionization efficiency and beam emittance. Furthermore, a low work function material was tested to reduce the contaminants and molecular sidebands generated inside the ion source. First results with ZrC ionizer tubes will be presented. Furthermore, a method to measure the energy distribution of the ion beam as a function of the time of flight will be discussed.

  9. Low-emittance uniform density Cs+ sources for heavy ion fusion accelerators studies

    International Nuclear Information System (INIS)

    Eylon, S.; Henestroza, E.; Garvey, T.; Johnson, R.; Chupp, W.

    1991-04-01

    Low-emittance (high-brightness) Cs + thermionic sources were developed for the heavy ion induction linac experiment MBE-4 at LBL. The MBE-4 linac accelerates four 10 mA beams from 200 ke V to 900 ke V while amplifying the current up to a factor of nine. Recent studies of the transverse beam dynamics suggested that characteristics of the injector geometry were contributing to the normalized transverse emissions growth. Phase-space and current density distribution measurements of the beam extracted from the injector revealed overfocusing of the outermost rays causing a hollow density profile. We shall report on the performance of a 5 mA scraped beam source (which eliminates the outermost beam rays in the diode) and on the design of an improved 10 mA source. The new source is based on EGUN calculations which indicated that a beam with good emissions and uniform current density could be obtained by modifying the cathode Pierce electrodes and using a spherical emitting surface. The measurements of the beam current density profile on a test stand were found to be in agreement with the numerical simulations. 3 refs., 6 figs

  10. A Comparison Study of Sinusoidal PWM and Space Vector PWM Techniques for Voltage Source Inverter

    Directory of Open Access Journals (Sweden)

    Ömer Türksoy

    2017-06-01

    Full Text Available In this paper, the methods used to control voltage source inverters which have been intensively investigated in recent years are compared. Although the most efficient result is obtained with the least number of switching elements in the inverter topologies, the method used in the switching is at least as effective as the topology. Besides, the selected switching method to control the inverter will play an effective role in suppressing harmonic components while producing the ideal output voltage. There are many derivatives of pulse width modulation techniques that are commonly used to control voltage source inverters. Some of widespread methods are sinusoidal pulse width modulation and space vector pulse width modulation techniques. These modulation techniques used for generating variable frequency and amplitude output voltage in voltage source inverters, have been simulated by using MATLAB/SIMULINK. And, the total harmonic distortions of the output voltages are compared. As a result of simulation studies, sinusoidal pulse width modulation has been found to have more total harmonic distortion in output voltages of voltage source inverters in the simulation. Space vector pulse width modulation has been shown to produce a more efficient output voltage with less total harmonic distortion.

  11. A preliminary study of synchrotron light sources for x-ray lithography

    International Nuclear Information System (INIS)

    Hoffmann, C.R.; Bigham, C.B.; Ebrahim, N.A.; Sawicki, J.A.; Taylor, T.

    1989-02-01

    A preliminary study of synchrotron light sources has been made, primarily oriented toward x-ray lithography. X-ray lithography is being pursued vigorously in several countries, with a goal of manufacturing high-density computer chips (0.25 μm feature sizes), and may attain commercial success in the next decade. Many other applications of soft x-rays appear worthy of investigation as well. The study group visited synchrotron radiation facilities and had discussions with members of the synchrotron radiation community, particularly Canadians. It concluded that accelerator technology for a conventional synchrotron light source appropriate for x-ray lithography is well established and is consistent with skills and experience at Chalk River Nuclear Laboratories. Compact superconducting systems are being developed also. Their technical requirements overlap with capabilities at Chalk River. (32 refs)

  12. An oxygen isotope study on hydrothermal sources of granite-type uranium deposits in South China

    International Nuclear Information System (INIS)

    Yongfei, Z.

    1987-01-01

    The usefulness of oxygen isotope measurements in solving problems of hydrothermal sources has been demonstrated in a number of detailed studies of the granite type uranium deposits in this paper. Remarkly the granite-type uranium deposits in Southr China have been shown to have formed from magmatic water, meteoric water, of mixtures of both the above, and origin of waters in the ore-forming fluid may be different for differing uranium deposits ore differing stages of the mineralization. Consequences obtained in this study for typical uranium deposits of different age and geologic sitting agree well with that obtained by other geologic-geochemical investigation. Furthermore, not only meteoric water is of importance to origin and evolution of the ore-forming fluid, but also mixing of waters from different sources is considered to be one of the most characteristic features of many hydrothermal uranium deposits related to granitoids or volcanics. (C.D.G.) [pt

  13. Development of a 170Tm source for mercury monitoring studies in humans using XRF

    International Nuclear Information System (INIS)

    Timmaraju, K. Phanisree; Fajurally, Bibi Najah; Armstrong, Andrea F.; Chettle, David R.

    2016-01-01

    The goals of the present study were to develop a 170 Tm radioisotope and generate a K XRF spectrum of mercury. Thulium foil and thulium oxide powder were both tested for impurities and the latter was found to be a better prospect for further studies. The 170 Tm radioisotope was developed from thulium oxide powder following the method of disolution and absorption. A suitable source holder and collimator were also designed based on Monte Carlo simulations. Using the radioisotope thus developed, a mercury XRF spectrum was successfully generated. - Highlights: • We tested the purity of thulium samples by XRF and NAA techniques. • Developed a procedure to generate Tm-170 isotope out of thulium oxide powder. • Designed a collimator and source holder • Generated XRF spectrum of mercury using the Tm-170 isotope. • Compared the highlights in mercury spectra from Tm-170 and Cd-109 isotopes.

  14. Correction of head movements in positron emission tomography using point source tracking system: a simulation study.

    Science.gov (United States)

    Nazarparvar, Babak; Shamsaei, Mojtaba; Rajabi, Hossein

    2012-01-01

    The motion of the head during brain positron emission tomography (PET) acquisitions has been identified as a source of artifact in the reconstructed image. In this study, a method is described to develop an image-based motion correction technique for correcting the post-acquisition data without using external optical motion-tracking system such as POLARIS. In this technique, GATE has been used to simulate PET brain scan using point sources mounted around the head to accurately monitor the position of the head during the time frames. The measurement of head motion in each frame showed a transformation in the image frame matrix, resulting in a fully corrected data set. Using different kinds of phantoms and motions, the accuracy of the correction method is tested and its applicability to experimental studies is demonstrated as well.

  15. Reactor-building-basement radionuclide and source distribution studies. Volume 3

    International Nuclear Information System (INIS)

    Cox, T.E.; Horan, J.T.; Worku, G.

    1983-06-01

    The Three Mile Island Unit 2 (TMI-2) Reactor Building basement has been sampled several times since August 1979. This report compiles the analytical results and sample history for the liquid and solid samples obtained to date. In addition, basement radiation levels were also obtained using thermoluminescent dosimeters (TLDs). The data obtained will provide information to support ongoing mass balance and source term studies and will aid in characterizing the 282-ft elevation for decontamination planning and dose reduction

  16. A Systematic Approach for Evaluating BPM Systems: Case Studies on Open Source and Proprietary Tools

    OpenAIRE

    Delgado , Andrea; Calegari , Daniel; Milanese , Pablo; Falcon , Renatta; García , Esteban

    2015-01-01

    Part 3: Examples and Case Studies; International audience; Business Process Management Systems (BPMS) provide support for modeling, developing, deploying, executing and evaluating business processes in an organization. Selecting a BPMS is not a trivial task, not only due to the many existing alternatives, both in the open source and proprietary realms, but also because it requires a thorough evaluation of its capabilities, contextualizing them in the organizational environment in which they w...

  17. High power laser source for space applications. Phase 1 study: Executive summary

    Science.gov (United States)

    1986-07-01

    A study to design a high power laser diode, to manufacture samples, to test them, and to identify the problems raised by the manufacture of such power sources in order to evaluate the effort required to overcome the difficulties in view of a component qualification was initiated. Theoretical modeling, manufacturing and test of samples, and environmental evaluation were completed. To obtain 200 mW monomode, a reversed CSP structure manufactured by chemical vapor deposition is recommended.

  18. A beamline for high-pressure studies at the Advanced Light Source with a superconducting bending magnet as the source.

    Science.gov (United States)

    Kunz, Martin; MacDowell, Alastair A; Caldwell, Wendel A; Cambie, Daniella; Celestre, Richard S; Domning, Edward E; Duarte, Robert M; Gleason, Arianna E; Glossinger, James M; Kelez, Nicholas; Plate, David W; Yu, Tony; Zaug, Joeseph M; Padmore, Howard A; Jeanloz, Raymond; Alivisatos, A Paul; Clark, Simon M

    2005-09-01

    A new facility for high-pressure diffraction and spectroscopy using diamond anvil high-pressure cells has been built at the Advanced Light Source on beamline 12.2.2. This beamline benefits from the hard X-radiation generated by a 6 T superconducting bending magnet (superbend). Useful X-ray flux is available between 5 keV and 35 keV. The radiation is transferred from the superbend to the experimental enclosure by the brightness-preserving optics of the beamline. These optics are comprised of a plane parabola collimating mirror, followed by a Kohzu monochromator vessel with Si(111) crystals (E/DeltaE approximately equal 7000) and W/B4C multilayers (E/DeltaE approximately equal 100), and then a toroidal focusing mirror with variable focusing distance. The experimental enclosure contains an automated beam-positioning system, a set of slits, ion chambers, the sample positioning goniometry and area detector (CCD or image-plate detector). Future developments aim at the installation of a second endstation dedicated to in situ laser heating and a dedicated high-pressure single-crystal station, applying both monochromatic and polychromatic techniques.

  19. Fundamental study on airborne electromagnetic survey using grounded source; Chihyo source gata kuchu denji tansa no kisoteki kenkyu. 2

    Energy Technology Data Exchange (ETDEWEB)

    Mogi, T; Fujimitsu, Y [Kyushu University, Fukuoka (Japan). Faculty of Engineering; Tanaka, Y [Kyoto University, Kyoto (Japan). Faculty of Science; Jomori, N [Chiba Electronics Research Institute, Chiba (Japan); Morikawa, T [Dowa Engineering Co. Ltd., Okayama (Japan); Kusunoki, K [Central Research Institute of Electric Power Industry, Tokyo (Japan)

    1997-05-27

    With an objective to develop an airborne electromagnetic survey method for greater depths achievable of exploration, a discussion was given on an exploration method of a type in which a transmitting device is placed on the ground to receive signals in an atmosphere. A prototype exploration apparatus is mounted with a fluxgate magnetometer, an attitude meter, a GPS, and a battery. This exploration apparatus is suspended on a 30 meter long rope from a helicopter to perform the exploration. Two flight tests on this apparatus were carried out in the Unzen area, Nagasaki Prefecture and the Motomiya area, Wakayama Prefecture. The ground source was extended to a distance of 1.5 km, and a current of about 20 A was flown with a quiescent wave having four-second cycles. The helicopter flew nearly horizontally at a ground speed of about 50 km, a flight altitude of 450 m above sea level, and a terrain clearances of 100 to 400 m. The obtained data had variations in correspondence with changes in roll and pitch angles, whereas the variation of about 5000 nT was reduced to about 1000 nT as a result of correction. It was not possible, however, to correct completely the variation with short cycles, requiring further discussions on frequency characteristics of the magnetometer. 6 figs., 1 tab.

  20. Source tagging modeling study of heavy haze episodes under complex regional transport processes over Wuhan megacity, Central China

    International Nuclear Information System (INIS)

    Lu, Miaomiao; Tang, Xiao; Wang, Zifa; Gbaguidi, Alex; Liang, Shengwen; Hu, Ke; Wu, Lin; Wu, Huangjian; Huang, Zhen; Shen, Longjiao

    2017-01-01

    Wuhan as a megacity of Central China was suffering from severe particulate matter pollution according to previous observation studies, however, the mechanism behind the pollution formation especially the impact of regional chemical transport is still unclear. This study, carried out on the Nested Air Quality Prediction Modeling System (NAQPMS) coupled with an on-line source-tagging module, explores different roles regional transport had in two strong haze episodes over Wuhan in October 2014 and quantitatively assesses the contributions from local and regional sources to PM 2.5 concentration. Validation of predictions based on observations shows modeling system good skills in reproducing key meteorological and chemical features. The first short-time haze episode occurred on 12 October under strong northerly winds, with a hourly PM 2.5 peak of 180 μg m −3 , and was found to be caused primarily by the long-range transport from the northern regions, which contributed 60.6% of the episode's PM 2.5 concentration (versus a total of 32.7% from sources in and near Wuhan). The second episode lasted from the 15–20 October under stable regional large-scale synoptic conditions and weak winds, and had an hourly PM 2.5 peak of 231.0 μg m −3 . In this episode, both the long-distance transport from far regions and short-range transport from the Wuhan-cluster were the primary causes of the haze episode and account for 24.8% and 29.2% of the PM 2.5 concentration respectively. Therefore, regional transport acts as a crucial driver of haze pollution over Wuhan through not only long-range transfer of pollutants, but also short-range aerosol movement under specific meteorological conditions. The present findings highlight the important role of regional transport in urban haze formation and indicate that the joint control of multi city-clusters are needed to reduce the particulate pollution level in Wuhan. - Highlights: • Regional transport impacts studied on two haze

  1. The State of Open Source Electronic Health Record Projects: A Software Anthropology Study.

    Science.gov (United States)

    Alsaffar, Mona; Yellowlees, Peter; Odor, Alberto; Hogarth, Michael

    2017-02-24

    Electronic health records (EHR) are a key tool in managing and storing patients' information. Currently, there are over 50 open source EHR systems available. Functionality and usability are important factors for determining the success of any system. These factors are often a direct reflection of the domain knowledge and developers' motivations. However, few published studies have focused on the characteristics of free and open source software (F/OSS) EHR systems and none to date have discussed the motivation, knowledge background, and demographic characteristics of the developers involved in open source EHR projects. This study analyzed the characteristics of prevailing F/OSS EHR systems and aimed to provide an understanding of the motivation, knowledge background, and characteristics of the developers. This study identified F/OSS EHR projects on SourceForge and other websites from May to July 2014. Projects were classified and characterized by license type, downloads, programming languages, spoken languages, project age, development status, supporting materials, top downloads by country, and whether they were "certified" EHRs. Health care F/OSS developers were also surveyed using an online survey. At the time of the assessment, we uncovered 54 open source EHR projects, but only four of them had been successfully certified under the Office of the National Coordinator for Health Information Technology (ONC Health IT) Certification Program. In the majority of cases, the open source EHR software was downloaded by users in the United States (64.07%, 148,666/232,034), underscoring that there is a significant interest in EHR open source applications in the United States. A survey of EHR open source developers was conducted and a total of 103 developers responded to the online questionnaire. The majority of EHR F/OSS developers (65.3%, 66/101) are participating in F/OSS projects as part of a paid activity and only 25.7% (26/101) of EHR F/OSS developers are, or have been

  2. Studying Regional Wave Source Time Functions Using the Empirical Green's Function Method: Application to Central Asia

    Science.gov (United States)

    Xie, J.; Schaff, D. P.; Chen, Y.; Schult, F.

    2013-12-01

    Reliably estimated source time functions (STFs) from high-frequency regional waveforms, such as Lg, Pn and Pg, provide important input for seismic source studies, explosion detection and discrimination, and minimization of parameter trade-off in attenuation studies. We have searched for candidate pairs of larger and small earthquakes in and around China that share the same focal mechanism but significantly differ in magnitudes, so that the empirical Green's function (EGF) method can be applied to study the STFs of the larger events. We conducted about a million deconvolutions using waveforms from 925 earthquakes, and screened the deconvolved traces to exclude those that are from event pairs that involved different mechanisms. Only 2,700 traces passed this screening and could be further analyzed using the EGF method. We have developed a series of codes for speeding up the final EGF analysis by implementing automations and user-graphic interface procedures. The codes have been fully tested with a subset of screened data and we are currently applying them to all the screened data. We will present a large number of deconvolved STFs retrieved using various phases (Lg, Pn, Sn and Pg and coda) with information on any directivities, any possible dependence of pulse durations on the wave types, on scaling relations for the pulse durations and event sizes, and on the estimated source static stress drops.

  3. Mass Transfer Limited Enhanced Bioremediation at Dnapl Source Zones: a Numerical Study

    Science.gov (United States)

    Kokkinaki, A.; Sleep, B. E.

    2011-12-01

    The success of enhanced bioremediation of dense non-aqueous phase liquids (DNAPLs) relies on accelerating contaminant mass transfer from the organic to the aqueous phase, thus enhancing the depletion of DNAPL source zones compared to natural dissolution. This is achieved by promoting biological activity that reduces the contaminant's aqueous phase concentration. Although laboratory studies have demonstrated that high reaction rates are attainable by specialized microbial cultures in DNAPL source zones, field applications of the technology report lower reaction rates and prolonged remediation times. One possible explanation for this phenomenon is that the reaction rates are limited by the rate at which the contaminant partitions from the DNAPL to the aqueous phase. In such cases, slow mass transfer to the aqueous phase reduces the bioavailability of the contaminant and consequently decreases the potential source zone depletion enhancement. In this work, the effect of rate limited mass transfer on bio-enhanced dissolution of DNAPL chlorinated ethenes is investigated through a numerical study. A multi-phase, multi-component groundwater transport model is employed to simulate DNAPL mass depletion for a range of source zone scenarios. Rate limited mass transfer is modeled by a linear driving force model, employing a thermodynamic approach for the calculation of the DNAPL - water interfacial area. Metabolic reductive dechlorination is modeled by Monod kinetics, considering microbial growth and self-inhibition. The model was utilized to identify conditions in which mass transfer, rather than reaction, is the limiting process, as indicated by the bioavailability number. In such cases, reaction is slower than expected, and further increase in the reaction rate does not enhance mass depletion. Mass transfer rate limitations were shown to affect both dechlorination and microbial growth kinetics. The complex dynamics between mass transfer, DNAPL transport and distribution, and

  4. Apixaban for treatment of embolic stroke of undetermined source (ATTICUS randomized trial): Rationale and study design.

    Science.gov (United States)

    Geisler, Tobias; Poli, Sven; Meisner, Christoph; Schreieck, Juergen; Zuern, Christine S; Nägele, Thomas; Brachmann, Johannes; Jung, Werner; Gahn, Georg; Schmid, Elisabeth; Bäezner, Hansjörg; Keller, Timea; Petzold, Gabor C; Schrickel, Jan-Wilko; Liman, Jan; Wachter, Rolf; Schön, Frauke; Schabet, Martin; Lindner, Alfred; Ludolph, Albert C; Kimmig, Hubert; Jander, Sebastian; Schlegel, Uwe; Gawaz, Meinrad; Ziemann, Ulf

    2017-12-01

    Rationale Optimal secondary prevention of embolic stroke of undetermined source is not established. The current standard in these patients is acetylsalicylic acid, despite high prevalence of yet undetected paroxysmal atrial fibrillation. Aim The ATTICUS randomized trial is designed to determine whether the factor Xa inhibitor apixaban administered within 7 days after embolic stroke of undetermined source, is superior to acetylsalicylic acid for prevention of new ischemic lesions documented by brain magnetic resonance imaging within 12 months after index stroke. Design Prospective, randomized, blinded, parallel-group, open-label, German multicenter phase III trial in approximately 500 patients with embolic stroke of undetermined source. A key inclusion criterion is the presence or the planned implantation of an insertable cardiac monitor. Patients are 1:1 randomized to apixaban or acetylsalicylic acid and treated for a 12-month period. It is an event-driven trial aiming for core-lab adjudicated primary outcome events. Study outcomes The primary outcome is the occurrence of at least one new ischemic lesion identified by axial T2-weighted FLAIR magnetic resonance imaging and/or axial DWI magnetic resonance imaging at 12 months when compared with the baseline magnetic resonance imaging. Key secondary outcomes are the combination of recurrent ischemic strokes, hemorrhagic strokes, systemic embolism; combination of MACE including recurrent stroke, myocardial infarction, and cardiovascular death and combination of major and clinically relevant non-major bleeding defined according to ISTH, and change of cognitive function and quality of life (EQ-5D, Stroke Impact Scale). Discussion Embolic stroke of undetermined source is caused by embolic disease and associated with a high risk of recurrent ischemic strokes and clinically silent cerebral ischemic lesions. ATTICUS will investigate the impact of atrial fibrillation detected by insertable cardiac monitor and the effects of

  5. A study of the consistent and the lumped source approximations in finite element neutron diffusion calculations

    International Nuclear Information System (INIS)

    Ozgener, B.; Azgener, H.A.

    1991-01-01

    In finite element formulations for the solution of the within-group neutron diffusion equation, two different treatments are possible for the group source term: the consistent source approximation (CSA) and the lumped source approximation (LSA). CSA results in intra-group scattering and fission matrices which have the same nondiagonal structure as the global coefficient matrix. This situation might be regarded as a disadvantage, compared to the conventional (i.e. finite difference) methods where the intra-group scattering and fission matrices are diagonal. To overcome this disadvantage, LSA could be used to diagonalize these matrices. LSA is akin to the lumped mass approximation of continuum mechanics. We concentrate on two different aspects of the source approximations. Although it has been reported that LSA does not modify the asymptotic h 2 convergence behaviour for linear elements, the effect of LSA on convergence of higher degree elements has not been investigated. Thus, we would be interested in determining, p, the asymptotic order of convergence, in: Δk |k eff (analytical) -k eff (finite element)| = Ch p (1) for finite element approximations of varying degree (N) with both of the source approximations. Since (1) is valid in the asymptotic limit, we must use ultra-fine meshes and quadruple precision arithmetic. For our order of convergence study, we used infinite cylindrical geometry with azimuthal symmetry. Hence, the effects of singularities remain uninvestigated. The second aspect we dwell on is the performance of LSA in bilinear 3-D finite element calculations, compared to CSA. LSA has been used quite extensively in 1- and 2-D even-parity transport and diffusion calculations. In this work, we will try to assess the relative merits of LSA and CSA in 3-D problems. (author)

  6. [Disclosure of sources of funding in biomedical journals. Descriptive study of four Spanish publications].

    Science.gov (United States)

    Roig, F; Borrego, A

    2015-01-01

    The source of research funding can result in bias, and its disclosure is essential in the publication of results. The aim of the study is to identify the frequency and type of sources of funding in the articles published by four Spanish biomedical journals published in Spanish. The frequency and type of financial disclosures in the articles published during 2012 in the ordinary numbers of Atención Primaria, Medicina Clínica, Revista Clínica Española and Revista Española de Cardiología were analyzed. Articles described as "Editorial", "Original article", "Consensus Document", "Review" and "Special Article" were considered. It was decided in each case whether or not the article included any funding disclosure and the type of the declared funding (public or private). Four hundred and twelve publications were analyzed. In 32.5% there was disclosure of funding: 38% in Atención Primaria, 27% in Medicina Clínica, 15% in Revista Clínica Española and 45% in Revista Española de Cardiología. By type of articles, 47% of original articles, 44% of consensus documents, 21% of reviews, 14% of special articles and 8% of editorials had a funding source. In 51.5% of the cases, funding was exclusively public, in 36.5% exclusively private and in 10% mixed. There is considerable variability in the disclosure of funding sources in articles appearing in these four Spanish biomedical journals. It would be necessary to improve the disclosure requirements of sources of funding, making them uniform, clear and transparent.

  7. Noise study of all-normal dispersion supercontinuum sources for potential application in optical coherence tomography

    Science.gov (United States)

    Gonzalo, I. B.; Engelsholm, R. D.; Bang, O.

    2018-03-01

    Commercially available silica-fiber-based and ultra-broadband supercontinuum (SC) sources are typically generated by pumping close to the zero-dispersion wavelength (ZDW) of a photonic crystal fiber (PCF), using high-power picosecond or nanosecond laser pulses. Despite the extremely broad bandwidths, such sources are characterized by large intensity fluctuations, limiting their performance for applications in imaging such as optical coherence tomography (OCT). An approach to eliminate the influence of noise sensitive effects is to use a so-called all-normal dispersion (ANDi) fiber, in which the dispersion is normal for all the wavelengths of interest. Pumping these types of fibers with short enough femtosecond pulses allows to suppress stimulated Raman scattering (SRS), which is known to be as noisy process as modulation instability (MI), and coherent SC is generated through self-phase modulation (SPM) and optical wave breaking (OWB). In this study, we show the importance of the pump laser and fiber parameters in the design of low-noise ANDi based SC sources, for application in OCT. We numerically investigate the pulse-to-pulse fluctuations of the SC, calculating the relative intensity noise (RIN) as a function of the pump pulse duration and fiber length. Furthermore, we experimentally demonstrate the role of the fiber length on the RIN of the ANDi SC, validating the results calculated numerically. In the end, we compare the RIN of a commercial SC source based on MI and the ANDi SC source developed here, which shows better noise performance when it is carefully designed.

  8. [Electronic cigarettes - effects on health. Previous reports].

    Science.gov (United States)

    Napierała, Marta; Kulza, Maksymilian; Wachowiak, Anna; Jabłecka, Katarzyna; Florek, Ewa

    2014-01-01

    Currently very popular in the market of tobacco products have gained electronic cigarettes (ang. E-cigarettes). These products are considered to be potentially less harmful in compared to traditional tobacco products. However, current reports indicate that the statements of the producers regarding to the composition of the e- liquids not always are sufficient, and consumers often do not have reliable information on the quality of the product used by them. This paper contain a review of previous reports on the composition of e-cigarettes and their impact on health. Most of the observed health effects was related to symptoms of the respiratory tract, mouth, throat, neurological complications and sensory organs. Particularly hazardous effects of the e-cigarettes were: pneumonia, congestive heart failure, confusion, convulsions, hypotension, aspiration pneumonia, face second-degree burns, blindness, chest pain and rapid heartbeat. In the literature there is no information relating to passive exposure by the aerosols released during e-cigarette smoking. Furthermore, the information regarding to the use of these products in the long term are not also available.

  9. On Road Study of Colorado Front Range Greenhouse Gases Distribution and Sources

    Science.gov (United States)

    Petron, G.; Hirsch, A.; Trainer, M. K.; Karion, A.; Kofler, J.; Sweeney, C.; Andrews, A.; Kolodzey, W.; Miller, B. R.; Miller, L.; Montzka, S. A.; Kitzis, D. R.; Patrick, L.; Frost, G. J.; Ryerson, T. B.; Robers, J. M.; Tans, P.

    2008-12-01

    The Global Monitoring Division and Chemical Sciences Division of the NOAA Earth System Research Laboratory have teamed up over the summer 2008 to experiment with a new measurement strategy to characterize greenhouse gases distribution and sources in the Colorado Front Range. Combining expertise in greenhouse gases measurements and in local to regional scales air quality study intensive campaigns, we have built the 'Hybrid Lab'. A continuous CO2 and CH4 cavity ring down spectroscopic analyzer (Picarro, Inc.), a CO gas-filter correlation instrument (Thermo Environmental, Inc.) and a continuous UV absorption ozone monitor (2B Technologies, Inc., model 202SC) have been installed securely onboard a 2006 Toyota Prius Hybrid vehicle with an inlet bringing in outside air from a few meters above the ground. To better characterize point and distributed sources, air samples were taken with a Portable Flask Package (PFP) for later multiple species analysis in the lab. A GPS unit hooked up to the ozone analyzer and another one installed on the PFP kept track of our location allowing us to map measured concentrations on the driving route using Google Earth. The Hybrid Lab went out for several drives in the vicinity of the NOAA Boulder Atmospheric Observatory (BAO) tall tower located in Erie, CO and covering areas from Boulder, Denver, Longmont, Fort Collins and Greeley. Enhancements in CO2, CO and destruction of ozone mainly reflect emissions from traffic. Methane enhancements however are clearly correlated with nearby point sources (landfill, feedlot, natural gas compressor ...) or with larger scale air masses advected from the NE Colorado, where oil and gas drilling operations are widespread. The multiple species analysis (hydrocarbons, CFCs, HFCs) of the air samples collected along the way bring insightful information about the methane sources at play. We will present results of the analysis and interpretation of the Hybrid Lab Front Range Study and conclude with perspectives

  10. Dietary intakes and food sources of fatty acids in Guatemalan schoolchildren: A cross-sectional study

    LENUS (Irish Health Repository)

    Bermudez, Odilia I.

    2010-04-23

    Abstract Background Consumption of healthy diets that contribute with adequate amounts of fat and fatty acids is needed for children. Among Guatemalan children, there is little information about fat intakes. Therefore, the present study sought to assess intakes of dietary fats and examine food sources of those fats in Guatemalan children. Methods The study subjects consisted of a convenience sample of 449 third- and fourth-grade schoolchildren (8-10 y), attending public or private schools in Quetzaltenango City, Guatemala. Dietary data was obtained by means of a single pictorial 24-h record. Results The percentages of total energy (%E) from total fat, saturated fat (SFA) and monounsaturated fat (MUFA) reached 29%E for total fat and 10%E for each SFA and MUFA, without gender differences. %E from fats in high vs. low-socio economic status (SES) children were significantly higher for boys, but not for girls, for total fat (p = 0.002) and SFA (p < 0.001). Large proportions of the children had low levels of intakes of some fatty acids (FA), particularly for n-3 FA, with >97% of all groups consuming less than 1%E from this fats. Fried eggs, sweet rolls, whole milk and cheese were main sources of total fat and, SFA. Whole milk and sweet bread were important sources of n-3 FA for high- and low-SES boys and girls, respectively. Fried plantain was the main source of n-3 FA for girls in the high-SES group. Fried fish, seafood soup, and shrimp, consumed only by boys in low amounts, were sources of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, which may explain the low intakes of these nutrients. Conclusions α-linolenic acid, EPA and DHA were the most limiting fatty acids in diets of Guatemalan schoolchildren, which could be partially explained by the low consumption of sources of these nutrients, particularly fish and seafood (for EPA and DHA). This population will benefit from a higher consumption of culturally acceptable foods that are rich in these limiting

  11. Raw data from orientation studies in crystalline rock areas of the southeastern United States. [Maps, tables of field data and analytical data for sections of North and South Carolina and Georgia, previously reported sites of uranium mineralization

    Energy Technology Data Exchange (ETDEWEB)

    Price, V.

    1976-03-01

    Raw data are presented on orientation studies conducted in crystalline rock areas of the Southeast which were chosen because of published references to uranium mineralization. Preliminary data for four orientation study areas are included. These areas are Lamar County, Georgia; Oconee County, South Carolina; Brush Creek, North Carolina; and North Harper, North Carolina. Sample locality maps, tables of field data, and tables of analytical data are included for each study area. (JGB)

  12. Verification of strontium isotopes and its possible source in Indian basmati rice for geographical authentication study

    International Nuclear Information System (INIS)

    Lagad, Rupali A.; Rai, Vinai K.; Singh, Sunil K.

    2015-01-01

    Due to globalization of food and agriculture product's market, there is increasing awareness of safety and authenticity of the food products. Consumers continuously demand the reassurance of origin and content of their foods. Hence safety and authenticity of food has been a growing analytical challenge. Basmati rice, the unique aromatic quality rice and a nature's gift to Indian sub-continent is produced and consumed on a large scale. Due to its profitable market as well as great demand overseas true Basmati rice market is facing unfair competition by unscrupulous producers for profit. Very few researches for geographical authentication are available for Indian basmati rice. Sr isotope composition of rice could be used as a geographical source indicator; however, little information is available on the possible source (lithogenic, biogenic, silicate, carbonate) of Sr in Rice or any other food stuff for tracing the geographical origin using Strontium isotopes as tracer. Hence in order to determine suitability of strontium isotopes as tracer and its possible source in rice for geographical authentication study, strontium isotope signature study of authentic Indian Basmati rice along with in situ soil and water of that region have been carried out

  13. Study of a new source for positive and negative ions. Final report

    International Nuclear Information System (INIS)

    Freedman, A.; Davidovits, P.

    1985-05-01

    This study has focused on the feasibility of a novel ion source based on the technique of photodissociation, which could provide both positive and negative ions at considerably higher intensities (potentially 10 15 cm -3 ) than are currently available. Ions are produced by irradiating a sample of a gaseous thallium halide salt with an argon fluoride excimer laser operating at 193 nm. At this wavelength, both thallium bromide and iodide will produce atomic ion pairs in a single photon process and molecular positive ions and an electron in a two-photon induced process. The potential traits of such an excimer-laser pumped thallium salt ion source include the following: high intensity and pulse rate, good spatial and temporal resolution, low temperature, good focusing properties, and production of heavy ions. This report describes a Phase I effort investigating the efficacy of this approach. A review of the relevant photophysics pertaining to laser excitation of thallium halide salts is presented, followed by a description of both experimental and theoretical efforts involving thallium bromide in particular. The last section will summarize the basic conclusions derived from these studies, as well as discuss potential advantages of an ion source derived from photolyzing thallium halide salts

  14. Managing previously disposed waste to today's standards

    International Nuclear Information System (INIS)

    1990-01-01

    A Radioactive Waste Management Complex (RWMC) was established at the Idaho National Engineering Laboratory (INEL) in 1952 for controlled disposal of radioactive waste generated at the INEL. Between 1954 and 1970 waste characterized by long lived, alpha emitting radionuclides from the Rocky Flats Plant was also buried at this site. Migration of radionuclides and other hazardous substances from the buried Migration of radionuclides and other hazardous substances from the buried waste has recently been detected. A Buried Waste Program (BWP) was established to manage cleanup of the buried waste. This program has four objectives: (1) determine contaminant sources, (2) determine extent of contamination, (3) mitigate migration, and (4) recommend an alternative for long term management of the waste. Activities designed to meet these objectives have been under way since the inception of the program. The regulatory environment governing these activities is evolving. Pursuant to permitting activities under the Resource Conservation and Recovery Act (RCRA), the Department of Energy (DOE) and the Environmental Protection Agency (EPA) entered into a Consent Order Compliance Agreement (COCA) for cleanup of past practice disposal units at the INEL. Subsequent to identification of the RWMC as a release site, cleanup activities proceeded under dual regulatory coverage of RCRA and the Atomic Energy Act. DOE, EPA, and the State of Idaho are negotiating a RCRA/Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Interagency Agreement (IAG) for management of waste disposal sites at the INEL as a result of the November 1989 listing of the INEL on the National Priority List (NPL). Decision making for selection of cleanup technology will be conducted under the CERCLA process supplemented as required to meet the requirements of the National Environmental Policy Act (NEPA). 7 figs

  15. Noise study of all-normal dispersion supercontinuum sources for potential application in optical coherence tomography

    DEFF Research Database (Denmark)

    Bravo Gonzalo, Ivan; Engelsholm, Rasmus Dybbro; Bang, Ole

    2017-01-01

    bandwidths, such sources are characterized by large intensity fluctuations, limiting their performance for applications in imaging such as optical coherence tomography (OCT). An approach to eliminate the influence of noise sensitive effects is to use a so-called all-normal dispersion (ANDi) fiber, in which...... the dispersion is normal for all the wavelengths of interest. Pumping these types of fibers with short enough femtosecond pulses allows to suppress stimulated Raman scattering (SRS), which is known to be as noisy process as modulation instability (MI), and coherent SC is generated through self-phase modulation...... (SPM) and optical wave breaking (OWB). In this study, we show the importance of the pump laser and fiber parameters in the design of low-noise ANDi based SC sources, for application in OCT. We numerically investigate the pulse-to-pulse fluctuations of the SC, calculating the relative intensity noise...

  16. Study on hybrid heat source overlap welding of magnesium alloy AZ31B

    International Nuclear Information System (INIS)

    Liang, G.L.; Zhou, G.; Yuan, S.Q.

    2009-01-01

    The magnesium alloy AZ31B was overlap welded by hybrid welding (laser-tungsten inert gas arc). According to the hybrid welding interaction principle, a new heat source model, hybrid welding heat source model, was developed with finite element analysis. At the same time, using a high-temperature metallographical microscope, the macro-appearance and microstructure characteristics of the joint after hybrid overlap welding were studied. The results indicate that the hybrid welding was superior to the single tungsten inert gas welding or laser welding on the aspects of improving the utilized efficiency of the arc and enhancing the absorptivity of materials to laser energy. Due to the energy characteristics of hybrid overlap welding the macro-appearance of the joint was cup-shaped, the top weld showed the hybrid welding microstructure, while, the lower weld showed the typical laser welding microstructure

  17. Study on hybrid heat source overlap welding of magnesium alloy AZ31B

    Energy Technology Data Exchange (ETDEWEB)

    Liang, G.L. [Department of Electromechanical Engineering, Tangshan College, Tangshan 063000 (China)], E-mail: guoliliang@sohu.com; Zhou, G. [School of Material Science and Engineering, Harbin Institute of Technology, Harbin 150001 (China); Yuan, S.Q. [Department of Electromechanical Engineering, Tangshan College, Tangshan 063000 (China)

    2009-01-15

    The magnesium alloy AZ31B was overlap welded by hybrid welding (laser-tungsten inert gas arc). According to the hybrid welding interaction principle, a new heat source model, hybrid welding heat source model, was developed with finite element analysis. At the same time, using a high-temperature metallographical microscope, the macro-appearance and microstructure characteristics of the joint after hybrid overlap welding were studied. The results indicate that the hybrid welding was superior to the single tungsten inert gas welding or laser welding on the aspects of improving the utilized efficiency of the arc and enhancing the absorptivity of materials to laser energy. Due to the energy characteristics of hybrid overlap welding the macro-appearance of the joint was cup-shaped, the top weld showed the hybrid welding microstructure, while, the lower weld showed the typical laser welding microstructure.

  18. A study of the response of a gas ionization chamber to different sources of ionizing radiation

    International Nuclear Information System (INIS)

    Zamble-Dieguez, F.E.

    1988-05-01

    The response of the TAMU Forward Hadron Calorimeter Chambers to neutrons from a 2 39Pu-Be source was investigated in hope of developing a strategy to reduce the effects of the background events called /open quotes/Texas towers/close quotes/ in the CDF trigger for the next run. The response to a standard ( 5 5Fe γ-ray) energy source was also studied and found to be similar to that of the chambers installed at CDF. In addition, the effects of different sampling gases and intermediate absorbers on the rate of large energy pulses were investigated. The neutron data were compared with the energy spectrum measured in CDF and that simulated using Monte Carlo techniques. It was found that the large energy pulse frequency can be reduced by as much as 50% if a non-hydrogenous sampling gas is used in conjunction with a neutron moderator

  19. A Feasibility Study on the Inspection System Development of Underground Cavities Using Neutron Source

    International Nuclear Information System (INIS)

    Yim, Che Wook; Kim, Song Hyun; Kim, Do Hyun; Shin, Chang Ho

    2015-01-01

    The detection efficiency using the gravimetry method is significantly low; therefore, it requires large surveying time. The magnetometry method detects the cavities by the magnitude of the magnetic field. However, the magnetometry method is problematical in urban areas due to pipes and electrical installations. GPR is the method that uses high frequency electromagnetic wave. This method is widely used for the inspection; however, the detection accuracy of sinkholes can be low in specific soil types. In this study, to verify the feasibility of the neutron source-based inspection system to detect the cavity detection, the Monte Carlo simulation was performed using neutron source. The analysis shows that the detection of the cavity with the given condition is possible when the diameter of cavity is over 100 cm. However, the detection efficiency can be enough increased if some optimization strategies for the inspection are developed. Also, it is expected that the proposed inspection method can detect the expected locations of the cavities

  20. Studies on a Q/A selector for the SECRAL electron cyclotron resonance ion source.

    Science.gov (United States)

    Yang, Y; Sun, L T; Feng, Y C; Fang, X; Lu, W; Zhang, W H; Cao, Y; Zhang, X Z; Zhao, H W

    2014-08-01

    Electron cyclotron resonance ion sources are widely used in heavy ion accelerators in the world because they are capable of producing high current beams of highly charged ions. However, the design of the Q/A selector system for these devices is challenging, because it must have a sufficient ion resolution while controlling the beam emittance growth. Moreover, this system has to be matched for a wide range of ion beam species with different intensities. In this paper, research on the Q/A selector system at the SECRAL (Superconducting Electron Cyclotron Resonance ion source with Advanced design in Lanzhou) platform both in experiment and simulation is presented. Based on this study, a new Q/A selector system has been designed for SECRAL II. The features of the new design including beam simulations are also presented.

  1. MIT modular x-ray source systems for the study of plasma diagnostics

    Science.gov (United States)

    Coleman, J. W.; Wenzel, K. W.; Petrasso, R. D.; Lo, D. H.; Li, C. K.; Lierzer, J. R.; Wei, T.

    1992-10-01

    Two new x-ray source systems are now on line at our facility. Each provides an e-beam to 25 kV. Targets are interchangeable between machines, and four x-ray detectors may be used simultaneously with a target. The gridded e-gun of the RACEHORSE system gives a 0.5-1.0-cm pulsable spot on target. The nongridded e-gun of the SCORPION system provides a 0.3-mm or smaller dc microspot on target. RACEHORSE is being used to study and characterize type-II diamond photoconductors for use in diagnosing plasmas, while SCORPION is being used to develop a slitless spectrograph using photographic film. Source design details and some RACEHORSE results are presented.

  2. Study on a groundwater source heat pump cooling system in solar greenhouse

    Energy Technology Data Exchange (ETDEWEB)

    Chai, Lilong; Ma, Chengwei [China Agricultural Univ., Beijing (China). Coll. of Water Conservancy and Civil Engineering. Dept. of Agricultural Structure and Bio-environmental Engineering], E-mail: macwbs@cau.edu.cn

    2008-07-01

    This study aims at exploiting the potential of ground source heat pump (GSHP) technology in cooling agricultural greenhouse, and advocating the use of renewable and clean energy in agriculture. GSHP has the multi-function of heating, cooling and dehumidifying, which is one of the fastest growing technologies of renewable energy air conditioning in recent years. The authors carried out experiment on the ground source heat pump system in cooling greenhouse in Beijing region during the summertime of 2007, and conducted analysis on the energy efficiency of the system by using coefficient of performance (COP). According to the data collected during Aug.13-18th, 2007, the coefficient of performance of GSHP system (COP{sub sys}) has reached 3.15 on average during the test. (author)

  3. Sun, wind, and waste have a role to play. Renewable energy sources merit continuing study

    Energy Technology Data Exchange (ETDEWEB)

    Higgin, R M.R.

    1976-09-23

    Renewable energy sources in Canada are not viewed as alternatives to coal, oil, gas or electricity, but may have a place in the energy future dependent on the economics as a supplement to conventional energy sources, particularly for local point-of-use applications. It appears that renewable energy systems will be expensive, have high front-end costs, and require supplemental systems and conservation (in view of the cost). Solar-heated houses built in southern Ontario with government assistance are described. Such houses are not economic yet, even with life-cycle costing. Windmills, including Darrieus rotors, are being studied and experimented with. Possibilities of converting wastes (sawdust, etc.) to a low-Btu gas by pyrolysis are being investigated to produce energy, reduce disposal costs, and lessen environmental impact. (LTN)

  4. Feasibility study on utilization of vitrified radioactive waste as radiation sources

    International Nuclear Information System (INIS)

    Makuuchi, Keizo; Yoshii, Fumio; Hyakutake, Kenichiro

    1995-01-01

    A feasibility study on utilization of vitrified high level radioactive waste (VW) as radiation source has been carried out. Natural rubber latex was radiation vulcanized with VW to demonstrate the feasibility. The dose rate was 0.1 kGy/hr. As a sensitizer, n-butyl acrylate was added. Negligible small activation of natural rubber (NR) latex by neutron from the VW was observed. The residual sensitizer in the irradiated latex and physical properties of film molded from the irradiated latex were the same level with the conventional radiation vulcanization of NR latex with γ-rays from Co-60. Surgical gloves and protective rubber gloves for radioactive contamination were produced from 20 litters of NR latex vulcanized with 2 VWs. The physical properties of both gloves were acceptable. These results suggested that vitrified high level waste can be used as an industrial radiation source. (author)

  5. [The use of personal sources for the study of emigration from Galicia: present state and perspectives].

    Science.gov (United States)

    Vazquez Gonzalez, A

    1996-08-01

    "Spanish sources for the study of emigration are sparse and fragmentary.... Mortgage documents for the payment of ocean transportation enable us to appreciate the spreading action of shipping agents; official listings of draft dodgers reveal that in general the River Plate was a favorite destination, rather than Cuba or Brazil. People from Galicia emigrated from rural origins to urban destinations in America; the analysis of place of birth of emigrants residing in A Coruna at the time of emigration show that there was also, in some cases, a first stage of rural-urban migration within Galicia. The general picture of emigration from Galicia is built [up] through the combination of the existing sources in Spain." (EXCERPT)

  6. Multi-year microbial source tracking study characterizing fecal contamination in an urban watershed

    Science.gov (United States)

    Bushon, Rebecca N.; Brady, Amie M. G.; Christensen, Eric D.; Stelzer, Erin A.

    2017-01-01

    Microbiological and hydrological data were used to rank tributary stream contributions of bacteria to the Little Blue River in Independence, Missouri. Concentrations, loadings and yields of E. coli and microbial source tracking (MST) markers, were characterized during base flow and storm events in five subbasins within Independence, as well as sources entering and leaving the city through the river. The E. coli water quality threshold was exceeded in 29% of base-flow and 89% of storm-event samples. The total contribution of E. coli and MST markers from tributaries within Independence to the Little Blue River, regardless of streamflow, did not significantly increase the median concentrations leaving the city. Daily loads and yields of E. coli and MST markers were used to rank the subbasins according to their contribution of each constituent to the river. The ranking methodology used in this study may prove useful in prioritizing remediation in the different subbasins.

  7. Studies Performed in Preparation for the Spallation Neutron Source Accumulator Ring Commissioning

    CERN Document Server

    Cousineau, Sarah M; Henderson, Stuart; Holmes, Jeffrey Alan; Plum, Michael

    2005-01-01

    The Spallation Neutron Source accumulator ring will compress 1.5?1014, 1 GeV protons from a 1 ms bun