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Sample records for source res pap

  1. Pap smear

    Science.gov (United States)

    ... AGUS - Pap; Atypical squamous cells - Pap; HPV - Pap; Human papilloma virus - Pap cervix - Pap; Colposcopy - Pap Images Female reproductive anatomy Pap smear Uterus Pap smear Cervical erosion References ...

  2. Some successful financing mechanisms for energy efficiency projects (EE) and projects using renewable energy sources (RES) - the experience of Bulgaria

    International Nuclear Information System (INIS)

    Uzunova, Boriana

    2004-01-01

    The paper analysis some of the most promising financial mechanisms for energy efficiency (EE) and renewable energy sources (RES) projects in Bulgaria - the TPF mechanism, the KIDS Fund, delivered by the EBRD fund the EE fund of the WB, established on the floor of the EE act, as well as a number of some of the pre accession and European energy programs used for financing this area. All data its rich intensive international and in -home work in the are of energy efficiency and renewable energy sources. (Author)

  3. Ongoing Horizontal and Vertical Transmission of Virulence Genes and papA Alleles among Escherichia coli Blood Isolates from Patients with Diverse-Source Bacteremia

    Science.gov (United States)

    Johnson, James R.; O'Bryan, Timothy T.; Kuskowski, Michael; Maslow, Joel N.

    2001-01-01

    The phylogenetic distributions of multiple putative virulence factors (VFs) and papA (P fimbrial structural subunit) alleles among 182 Escherichia coli blood isolates from patients with diverse-source bacteremia were defined. Phylogenetic correspondence among these strains, the E. coli Reference (ECOR) collection, and other collections of extraintestinal pathogenic E. coli (ExPEC) was assessed. Although among the 182 bacteremia isolates phylogenetic group B2 predominated, exhibited the greatest concentration of individual VFs, and contained the largest number of familiar virulent clones, other phylogenetic groups exhibited greater concentrations of certain VFs than did group B2 and included several additional virulent clones. Certain of the newly detected VF genes, e.g., fyuA (yersiniabactin; 76%) and focG (F1C fimbriae; 25%), were as prevalent or more prevalent than their more familiar traditional counterparts, e.g., iut (aerobactin; 57%) and sfaS (S fimbriae; 14%), thus possibly offering additional useful targets for preventive interventions. Considerable diversity of VF profiles was observed at every level within the phylogenetic tree, including even within individual lineages. This suggested that many different pathways can lead to extraintestinal virulence in E. coli and that the evolution of ExPEC, which involves extensive horizontal transmission of VFs and continuous remodeling of pathogenicity-associated islands, is a highly active, ongoing process. PMID:11500406

  4. Les jachères de légumineuses arborescentes : sources potentielles ...

    African Journals Online (AJOL)

    SARAH

    30 sept. 2014 ... sources potentielles de bois énergie et de service en. Côte d'Ivoire. GNAHOUA .... bactéries du genre Rhizobium, ce qui leur confère une relative autonomie ..... fondamentales et rôle dans l'aménagement des écosystèmes ...

  5. Renewable energy sources (RES) projects and their barriers on a regional scale: The case study of wind parks in the Dodecanese islands, Greece

    International Nuclear Information System (INIS)

    Oikonomou, Emmanouil K.; Kilias, Vassilios; Goumas, Aggelos; Rigopoulos, Alexandrous; Karakatsani, Eirini; Damasiotis, Markos; Papastefanakis, Dimitrios; Marini, Natassa

    2009-01-01

    The increasing energy challenges faced, in particular, by isolated communities, such as insular communities, call for an integrated, flexible and easy-to-apply methodology aiming at providing a list of renewable energy sources) (RES) projects capable to reduce green house gas (GHG) emissions, satisfy future energy forecasts and reach the objectives of international/national energy directives and obligations, as, for example, the ones set by the Kyoto Protocol by 2010. The EU project EMERGENCE 2010 developed such a methodology that is implemented here in the case study of wind parks in the Dodecanese islands in Greece. The results obtained consist of a final list of financially viable RES wind projects, for which various barriers have been previously identified and assessed. The additional advantages of the proposed methodology is that besides providing as an end result a comprehensive list of RES projects adopted to specific criteria and regional priorities, it also allows space for involving - from early stages - the local community and stakeholders in the decision-making process (participatory planning); in this way, the EMERGENCE 2010 methodology may assist towards the RES promotion and public acceptance, the profitability of RES investments and the regional sustainable development.

  6. Long-term Field Experiments as Important Source of Knowledge - Aims of the BonaRes Data Centre

    Science.gov (United States)

    Grosse, Meike; Hierold, Wilfried

    2017-04-01

    BonaRes is short for "soil as a sustainable resource for the bioeconomy". It is funded by the German Federal Ministry of Education and Research (BMBF) under the umbrella of the National Research Strategy BioEconomy 2030. BonaRes consists of ten interdisciplinary research project consortia and the 'BonaRes - Centre for Soil Research' (see also Wollschläger et al 2016). It is one task of the BonaRes Data Centre as part of the 'BonaRes - Centre for Soil Research', to collect data and meta-data of agricultural long-term field experiments (LTFE) in Germany. The definition of LTFE in the context of BonaRes is a minimum duration of twenty years and a static design. LTFE are essential research infrastructures for agricultural sciences and soil sciences amongst other disciplines. Some LTFE run since a very long time; the start of the oldest one in Germany was 1878. Therefore, in many cases valuable time series exist. Data sets of LTFE shall be compiled and made publicly available by the BonaRes Data Centre. The public availability together with an easy access will lead to an enhanced usability of the data. This probably makes the LTFE itself more valuable through an improved visibility and may also help to maintain the LTFE. Beyond the data compilation there is the possibility for every data owner to make a data publication, which offers an additional value for the data owner after his first right of use. A first step towards a joint database is a compilation of all existing LTFE in Germany with meta information to each trial. This information is shown in an interactive web map, what is completely new in that context. Besides the exact position of the LTFE the following metadata are shown: name of the LTFE, website (if available), institution, land use category, participation in existing networks, research theme, start (and maybe end) of the trial, and research parameters. Details on the meta information will be presented in the speech. Literature Wollschläger, U; Helming

  7. Practice Study Outpatient Psychotherapy - Switzerland (PAP-S) : Study design and feasibility (Revised edition)

    OpenAIRE

    Wyl, Agnes von; Crameri, Aureliano; Koemeda, Margit; Tschuschke, Volker; Schulthess, Peter

    2016-01-01

    Revised edition of Von Wyl, A., Crameri, A., Koemeda, M., Tschuchke, V. & Schulthess, P. (2013). The PAP-S (Practice of Ambulant Psychotherapy-Study), Switzerland: Study Design and Feasibility. Zurich University of Applied Sciences, Zurich. The original article was published in German: von Wyl, A., Crameri, A., Koemeda, M., Tschuschke, V. & Schulthess, P. (2013). Praxisstudie ambulante Psychotherapie Schweiz (PAP-S): Studiendesign und Machbarkeit. Psychotherapie-Wissenschaft, 1, 6-22; op...

  8. Cost-Efficient and Sustainable Deployment of Renewable Energy Sources towards the 20% Target by 2020, and beyond. D5.3. Key recommendations from the RES4LESS roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Dalla Longa, F. [ECN Policy Studies, Amsterdam (Netherlands); Raimundo, C. [IT Power, Bristol, Avon (United Kingdom)

    2012-12-15

    In its Directive 2009/28/EC the European Commission (EC) set an ambitious 20% target on the final consumption of energy from renewable sources (RES) in 2020 (European Commission, 2009). This EU-level target is divided into different domestic targets for each single Member State (MS). The MS-level targets do not always reflect the domestic RES potentials, creating a situation where certain MSs will have to deploy very expensive technologies in order to meet their target, while other countries are expected to reach their target at lower costs and even produce a RES surplus. In order to promote a more balanced distribution of costs, the Directive allows MSs to establish cooperation mechanisms. Three types of cooperation mechanisms are defined: a MS could buy the RES-credits associated with the surplus potential of other MSs via statistical transfers, could finance additional RES deployment in other MSs by engaging in joint projects, or could share (part of) its RES potential with other MSs by establishing joint support schemes.

  9. Rates of initial acceptance of PAP masks and outcomes of mask switching.

    Science.gov (United States)

    Bachour, Adel; Vitikainen, Pirjo; Maasilta, Paula

    2016-05-01

    Recently, we noticed a considerable development in alleviating problems related to positive airway pressure (PAP) masks. In this study, we report on the initial PAP mask acceptance rates and the effects of mask switching on mask-related symptoms. We prospectively collected all cases of mask switching in our sleep unit for a period of 14 months. At the time of the study, we used ResMed™ CPAP devices and masks. Mask switching was defined as replacing a mask used for at least 1 day with another type of mask. Changing to a different size but keeping the same type of mask did not count as mask switching. Switching outcomes were considered failed if the initial problem persisted or reappeared during the year that followed switching. Our patient pool was 2768. We recorded 343 cases of mask switching among 267 patients. Of the 566 patients who began new PAP therapy, 108 (39 women) had switched masks, yielding an initial mask acceptance rate of 81 %. The reason for switching was poor-fit/uncomfortable mask in 39 %, leak-related in 30 %, outdated model in 25 %, and nasal stuffiness in 6 % of cases; mask switching resolved these problems in 61 %. Mask switching occurred significantly (p = 0.037) more often in women and in new PAP users. The odds ratio for abandoning PAP therapy within 1 year after mask switching was 7.2 times higher (interval 4.7-11.1) than not switching masks. The initial PAP mask acceptance rate was high. Patients who switched their masks are at greater risk for abandoning PAP therapy.

  10. Pap Tests and Foreign-Born Women

    Centers for Disease Control (CDC) Podcasts

    Foreign-born women living in the U.S. are less likely to have Pap tests to detect cervical cancer than women born in this country. The problem is worse for women from certain countries or regions. Find out why this is a disturbing trend, who these women are and why they are less likely to get a Pap test, and what CDC is doing about it.

  11. papA gene of avian pathogenic Escherichia coli.

    Science.gov (United States)

    Kariyawasam, Subhashinie; Nolan, Lisa K

    2011-12-01

    P fimbrial adhesins may be associated with the virulence of avian pathogenic Escherichia coli (APEC). However, most APECs are unable to express P fimbriae even when they are grown under conditions that favor P fimbrial expression. This failure can be explained by the complete absence of the pap operon or the presence of an incomplete pap operon in Pap-negative APEC strains. In the present study, we analyzed the pap operon, specifically the papA gene that encodes the major fimbrial shaft, to better understand the pap gene cluster at the genetic level. First, by PCR, we examined a collection of 500 APEC strains for the presence of 11 genes comprising the pap operon. Except for papA, all the other genes of the operon were present in 38% to 41.2% of APEC, whereas the papA was present only in 10.4% of the APEC tested. Using multiplex PCR to probe for allelic variants of papA, we sought to determine if the low prevalence of papA among APEC was related to genetic heterogeneity of the gene itself. It was determined that the papA of APEC always belongs to the F11 allelic variant. Finally, we sequenced the 'papA region' from two papA-negative strains, both of which contain all the other genes of the pap operon. Interestingly, both strains had an 11,104-bp contig interruptingpapA at the 281-bp position. This contig harbored a streptomycin resistance gene and a classic Tn10 transposon containing the genes that confer tetracycline resistance. However, we noted that the papA gene of every papA-negative APEC strain was not interrupted by an 11,104-bp contig. It is likely that transposons bearing antibiotic resistance genes have inserted within pap gene cluster of some APEC strains, and such genetic events may have been selected for by antibiotic use.

  12. Pap Tests and Foreign-Born Women

    Centers for Disease Control (CDC) Podcasts

    2007-11-26

    Foreign-born women living in the U.S. are less likely to have Pap tests to detect cervical cancer than women born in this country. The problem is worse for women from certain countries or regions. Find out why this is a disturbing trend, who these women are and why they are less likely to get a Pap test, and what CDC is doing about it.  Created: 11/26/2007 by National Breast and Cervical Cancer Early Detection Program.   Date Released: 12/7/2007.

  13. Apports de l’archéobotanique à la compréhension de la Source des Roches, Chamalières (Puy-de-Dôme The archaeobotanic contribution to the understanding of la Source des Roches, Chamalières (Puy-de-Dôme

    Directory of Open Access Journals (Sweden)

    Béatrice Prat

    2008-04-01

    Full Text Available Au tout début de la période romaine, un taux d’arbres inhabituellement élevé a été mis en évidence par la palynologie sur le site de la Source des Roches à Chamalières (Puy-de-Dôme, gisement qui a livré plus de 3500 ex-voto en bois au début des années 70. Durant le second âge du Fer et l’époque romaine, un tel niveau de boisement n’est observé nulle part ailleurs, ni en plaine de Limagne, ni sur le plateau des Dômes. L’hypothèse d’un sanctuaire de plein air, soutenue par Anne-Marie Romeuf qui a dirigé la fouille, se trouve ainsi confortée par l’analyse pollinique, qui permet d’envisager la possibilité de la présence d’un « bois sacré » composé principalement de chênes. La combinaison des données archéobotaniques issues de la palynologie et de la carpologie contribue à renforcer la compréhension du site d’un point de vue paysager et nous renseigne également sur les types d’offrandes végétales associées au dépôt des ex-voto.Unusually high levels of tree pollen were revealed by palynology on the site of the Source des Roches in Chamalières (Puy-de-Dôme for the very beginning of the Roman period. The site had yielded more than 3500 wooden offerings in the early 70s. Such a high density of woodland can be found nowhere else for the Second Iron Age and the Roman period, neither in the plain of Limagne, nor on the plateau of Les Dômes. The hypothesis of an open air sanctuary, first advanced by Anne-Marie Romeuf, director of excavation, is therefore reinforced by the pollen analysis which leads us to consider the possibility that a “sacred grove” made up principally of oaks was present. The correlation of the archaeobotanic data from palynology and paleœthnobotany contributes to the strengthening of the site’s knowledge from the landscape’s point of view. We also have a better understanding of the vegetal offerings associated with the wooden statues.

  14. The Bolivian Source Rocks. Sub Andean Zone. Madre de Dios. Chaco Les roches mères de Bolivie. Subandin. Madre de Dios. Chaco

    Directory of Open Access Journals (Sweden)

    Diaz Martinez E.

    2006-11-01

    Full Text Available A complete study of source-rock geochemical data has been carried out for the Bolivian foothills and foreland (Sub Andean Zone, Chaco and Madre de Dios in order to quantify the petroleum potential of the area. Overall available data have been compiled in a database, and a synthesis of the results is presented here. Besides the classical mid-Devonian source rocks (Tequeje Fm in the north, Limoncito Fm in the center and Los Monos Fm in the south, others may be just as important : theTomachi Fm (late Devonian in the north of the country and the Copacabana Fm. (late Carboniferous-early Permian in the northern Sub Andean Zone. Both present an excellent potential with S2 up to 40 mg HC/g and average values larger than 10 mg HC/g on few hundred meters. The latest Cretaceous (Flora Fm in the northern Sub Andean Zone also presents locally a high potential but has almost no influence, its thickness being quite reduced. Almost all the source rocks matured during the Neogene due to the subsidence in the Andean foreland and, locally, in the piggyback basins, and are thus involved in the current petroleum system. Silurian and Lower Paleozoic units also contain thick shale beds, but these source rocks were mature before the Jurassic in most of the country, except in the Chaco, the Boomerang and the central Sub Andean Zone, where the Silurian is not nowadays overmature and may play an important role. The different zones are compared based on their Source Potential Index (SPI which indicates that the richest areas are the northern Sub Andean Zone and the Madre de Dios basin with SPI greater than 10 t/m². Since these two areas remain almost unexplored and, at least for the northern Sub Andean zone, present very large structures, these results allow to be optimistic about the possibilities for future exploration. Une base de données géochimiques a été mise en place entre 1994 et 1995 à YPFB (Yacimientos Petrolíferos Fiscales Bolivianos afin de regrouper les

  15. Pap smear receipt among Vietnamese immigrants: the importance of health care factors.

    Science.gov (United States)

    Taylor, Victoria M; Yasui, Yutaka; Nguyen, Tung T; Woodall, Erica; Do, H Hoai; Acorda, Elizabeth; Li, Lin; Choe, John; Jackson, J Carey

    2009-12-01

    Recent US data indicate that women of Vietnamese descent have higher cervical cancer incidence rates than women of any other race/ethnicity, and lower levels of Pap testing than white, black, and Latina women. Our objective was to provide information about Pap testing barriers and facilitators that could be used to develop cervical cancer control intervention programs for Vietnamese American women. We conducted a cross-sectional, community-based survey of Vietnamese immigrants. Our study was conducted in metropolitan Seattle, Washington, DC. A total of 1532 Vietnamese American women participated in the study. Demographic, health care, and knowledge/belief items associated with previous cervical cancer screening participation (ever screened and screened according to interval screening guidelines) were examined. Eighty-one percentage of the respondents had been screened for cervical cancer in the previous three years. Recent Pap testing was strongly associated (p<0.001) with having a regular doctor, having a physical in the last year, previous physician recommendation for testing, and having asked a physician for testing. Women whose regular doctor was a Vietnamese man were no more likely to have received a recent Pap smear than those with no regular doctor. Our findings indicate that cervical cancer screening disparities between Vietnamese and other racial/ethnic groups are decreasing. Efforts to further increase Pap smear receipt in Vietnamese American communities should enable women without a source of health care to find a regular provider. Additionally, intervention programs should improve patient-provider communication by encouraging health care providers (especially male Vietnamese physicians serving women living in ethnic enclaves) to recommend Pap testing, as well as by empowering Vietnamese women to specifically ask their physicians for Pap testing.

  16. Is there a language divide in pap test use?

    Science.gov (United States)

    Ponce, Ninez A; Chawla, Neetu; Babey, Susan H; Gatchell, Melissa S; Etzioni, David A; Spencer, Benjamin A; Brown, E Richard; Breen, Nancy

    2006-11-01

    We sought to determine whether primary language use, measured by language of interview, is associated with disparities in cervical cancer screening. We undertook a secondary data analysis of a pooled sample of the 2001 and 2003 California Health Interview Surveys. The surveys were conducted in English, Spanish, Cantonese, Mandarin, Korean, and Vietnamese. The study was a cross-sectional analysis of 3-year Pap test use among women ages 18 to 64, with no reported cervical cancer diagnosis or hysterectomy (n = 38,931). In addition to language of interview, other factors studied included race/ethnicity, marital status, income, educational attainment, years lived in the United States, insurance status, usual source of care, smoking status, area of residence, and self-rated health status. We fit weighted multivariate logit models predicting 3-year Pap test use as a function of language of interview, adjusting for the effects of specified covariates. Compared with the referent English interview group, women who interviewed in Spanish were 1.65 times more likely to receive a Pap test in the past 3 years. In contrast, we observed a significantly reduced risk of screening among women who interviewed in Vietnamese (odds ratio [OR] 0.67; confidence interval [CI] 0.48-0.93), Cantonese (OR 0.44; 95% CI 0.30-0.66), Mandarin (OR 0.48; 95% CI 0.33-0.72), and Korean (OR 0.62; 0.40-0.98). Improved language access could reduce cancer screening disparities, especially in the Asian immigrant community.

  17. In medias res

    DEFF Research Database (Denmark)

    Foote, Jonathan

    2017-01-01

    nor does he begin the Trojan War ab ovo (with the egg) but always he hurries to the action and snatches the listener in medias res (into the middle of things)      Horace, Ars Poetica 145–147 Good epic poets do not commence their tale from the beginning—ab ovo (with the egg)—as Horace states......, but rather descend in medias res (into the middle of things), a reference to the Illiad opening already many years into the Trojan War. Perhaps this sentiment of plunging into the middle of action was felt by researchers in 1976 when, upon the walls of the San Lorenzo New Sacristy in Florence, they uncovered...

  18. Enhancement of Chlorogenic Acid Production in Hairy Roots of Platycodon grandiflorum by Over-Expression of An Arabidopsis thaliana Transcription Factor AtPAP1

    Directory of Open Access Journals (Sweden)

    Pham Anh Tuan

    2014-08-01

    Full Text Available To improve the production of chlorogenic acid (CGA in hairy roots of Platycodon grandiflorum, we induced over-expression of Arabidopsis thaliana transcription factor production of anthocyanin pigment (AtPAP1 using an Agrobacterium rhizogenes-mediated transformation system. Twelve hairy root lines showing over-expression of AtPAP1 were generated. In order to investigate the regulation of AtPAP1 on the activities of CGA biosynthetic genes, the expression levels of seven P. grandiflorum CGA biosynthetic genes were analyzed in the hairy root line that had the greatest accumulation of AtPAP1 transcript, OxPAP1-1. The introduction of AtPAP1 increased the mRNA levels of all examined CGA biosynthetic genes and resulted in a 900% up-regulation of CGA accumulation in OxPAP1-1 hairy roots relative to controls. This suggests that P. grandiflorum hairy roots that over-express the AtPAP1 gene are a potential alternative source of roots for the production of CGA.

  19. Trends in Pap test practices and results: An 11-year review of the annual ACHA Pap Test and STI Survey.

    Science.gov (United States)

    Eastman-Mueller, Heather P; Oswalt, Sara B

    2017-10-01

    To conduct a trend analysis of Pap test practices, Pap test results and related women's services and guidelines of college health centers. College health centers who participated in the annual ACHA Pap Test and STI (sexually transmitted infection) Survey years 2004-2014 (n ranged from 127 to 181 depending on year). Descriptive analyses are presented with ANOVAs (Analysis of Variance) and chi-square tests calculated to examine trends over time. The number of Pap tests significantly decreased over time; however, the percentage of normal and HSIL (high-grade squamous intraepithelial lesion) results did not vary. Availability of conventional cytology slides and cryotherapy were significantly associated with year. Over time, college health centers' guidelines related to initiation of Pap testing evolved to consistently conform to national recommendations for cervical screening. The results indicate most college health centers are following the current national guidelines regarding Pap testing for young adult women.

  20. ResStock Analysis Tool | Buildings | NREL

    Science.gov (United States)

    Energy and Cost Savings for U.S. Homes Contact Eric Wilson to learn how ResStock can benefit your approach to large-scale residential energy analysis by combining: Large public and private data sources uncovered $49 billion in potential annual utility bill savings through cost-effective energy efficiency

  1. Decision Making for Pap Testing among Pacific Islander Women

    Science.gov (United States)

    Weiss, Jie W.; Mouttapa, Michele; Sablan-Santos, Lola; DeGuzman Lacsamana, Jasmine; Quitugua, Lourdes; Park Tanjasiri, Sora

    2016-01-01

    This study employed a Multi-Attribute Utility (MAU) model to examine the Pap test decision-making process among Pacific Islanders (PI) residing in Southern California. A total of 585 PI women were recruited through social networks from Samoan and Tongan churches, and Chamorro family clans. A questionnaire assessed Pap test knowledge, beliefs and…

  2. High prevalence of abnormal Pap smears among young women co ...

    African Journals Online (AJOL)

    Standardised questionnaires were used to collect sociodemographic and clinical presentation data from women attending family planning and other reproductive health services. Pap smears were done using standard methods. Pap smear data were linked to HIV serostatus. Results. Four hundred and sixty-six women were ...

  3. Aerobic biotransformation of polyfluoroalkyl phosphate esters (PAPs) in soil

    International Nuclear Information System (INIS)

    Liu, Chen; Liu, Jinxia

    2016-01-01

    Microbial transformation of polyfluoroalkyl phosphate esters (PAPs) into perfluorocarboxylic acids (PFCAs) has recently been confirmed to occur in activated sludge and soil. However, there lacks quantitative information about the half-lives of the PAPs and their significance as the precursors to PFCAs. In the present study, the biotransformation of 6:2 and 8:2 diPAP in aerobic soil was investigated in semi-dynamics reactors using improved sample preparation methods. To develop an efficient extraction method for PAPs, six different extraction solvents were compared, and the phenomenon of solvent-enhanced hydrolysis was investigated. It was found that adding acetic acid could enhance the recoveries of the diPAPs and inhibit undesirable hydrolysis during solvent extraction of soil. However 6:2 and 8:2 monoPAPs, which are the first breakdown products from diPAPs, were found to be unstable in the six solvents tested and quickly hydrolyzed to form fluorotelomer alcohols. Therefore reliable measurement of the monoPAPs from a live soil was not achievable. The apparent DT_5_0 values of 6:2 diPAP and 8:2 diPAP biotransformation were estimated to be 12 and > 1000 days, respectively, using a double first-order in parallel model. At the end of incubation of day 112, the major degradation products of 6:2 diPAP were 5:3 fluorotelomer carboxylic acid (5:3 acid, 9.3% by mole), perfluoropentanoic acid (PFPeA, 6.4%) and perfluorohexanoic acid (PFHxA, 6.0%). The primary product of 8:2 diPAP was perfluorooctanoic acid (PFOA, 2.1%). The approximately linear relationship between the half-lives of eleven polyfluoroalkyl and perfluoroalkyl substances (PFASs, including 6:2 and 8:2 diPAPs) that biotransform in aerobic soils and their molecular weights suggested that the molecular weight is a good indicator of the general stability of low-molecular-weight PFAS-based compounds in aerobic soils. - Highlights: • Biotransformation of 6:2 and 8:2 diPAPs in an aerobic soil was investigated.

  4. Aerobic biotransformation of polyfluoroalkyl phosphate esters (PAPs) in soil.

    Science.gov (United States)

    Liu, Chen; Liu, Jinxia

    2016-05-01

    Microbial transformation of polyfluoroalkyl phosphate esters (PAPs) into perfluorocarboxylic acids (PFCAs) has recently been confirmed to occur in activated sludge and soil. However, there lacks quantitative information about the half-lives of the PAPs and their significance as the precursors to PFCAs. In the present study, the biotransformation of 6:2 and 8:2 diPAP in aerobic soil was investigated in semi-dynamics reactors using improved sample preparation methods. To develop an efficient extraction method for PAPs, six different extraction solvents were compared, and the phenomenon of solvent-enhanced hydrolysis was investigated. It was found that adding acetic acid could enhance the recoveries of the diPAPs and inhibit undesirable hydrolysis during solvent extraction of soil. However 6:2 and 8:2 monoPAPs, which are the first breakdown products from diPAPs, were found to be unstable in the six solvents tested and quickly hydrolyzed to form fluorotelomer alcohols. Therefore reliable measurement of the monoPAPs from a live soil was not achievable. The apparent DT50 values of 6:2 diPAP and 8:2 diPAP biotransformation were estimated to be 12 and > 1000 days, respectively, using a double first-order in parallel model. At the end of incubation of day 112, the major degradation products of 6:2 diPAP were 5:3 fluorotelomer carboxylic acid (5:3 acid, 9.3% by mole), perfluoropentanoic acid (PFPeA, 6.4%) and perfluorohexanoic acid (PFHxA, 6.0%). The primary product of 8:2 diPAP was perfluorooctanoic acid (PFOA, 2.1%). The approximately linear relationship between the half-lives of eleven polyfluoroalkyl and perfluoroalkyl substances (PFASs, including 6:2 and 8:2 diPAPs) that biotransform in aerobic soils and their molecular weights suggested that the molecular weight is a good indicator of the general stability of low-molecular-weight PFAS-based compounds in aerobic soils. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Comentário sobre as Res Gestae Divi Avgvsti

    Directory of Open Access Journals (Sweden)

    Maria Luiza Corassin

    2004-12-01

    Full Text Available This article studies an epigraphic source, Augustus's Res gestae, which provides elements that elucidate the construction of the imperial power system and the relationship between ruler and ruled.

  6. Res Publica aps / Erkki Bahovski

    Index Scriptorium Estoniae

    Bahovski, Erkki, 1970-

    2003-01-01

    Autori sõnul tekitavad tänavatel ülesseatud postrid, kus peaminister Juhan Parts kutsub üles ütlema "jah" Euroopa Liidule, kummastust, sest ehkki on tegemist Res Publica kampaaniaga, on tavainimesel raske vahet teha valitsuse justkui neutraalse referendumikampaania ja Res Publica "jah"-kampaania vahel

  7. Lõhe Res Publicas / Eve Heinla

    Index Scriptorium Estoniae

    Heinla, Eve, 1966-

    2005-01-01

    Tallinna linnapea Tõnis Palts on vastu Tallinna volikogu Res Publica fraktsiooni esimehe Toomas Tautsi abikaasa Kristina Tautsi tööleasumisele Lääne-Tallinna keskhaigla haldusjuhina. T. Paltsi kirjast Res Publica Tallinna piirkonna juhatusele. Lisa: Kuidas lahvatas pealinna võimutüli. Kommenteerivad: Maret Maripuu, Tõnis Palts, Vladimir Maslov

  8. A European Res publica

    Directory of Open Access Journals (Sweden)

    Ola Zetterquist

    2011-05-01

    Full Text Available The article analyses the fundamental constitutional enigma of the European Union (EU, namely whether the EU can be considered as a (from its Member States separate and independent constitutional legal order. The EU is often referred to as a legal order sui generis, i.e. of a unique character that defies traditional definitions. More specifically, the notion of an independent and separate EU is at odds with the idea of the sovereign state. The notion of the EU as a legal order sui generis is too much influenced by the models of the sovereign state and sovereignty (in the vein of Thomas Hobbes. The key component in the Hobbesian idea of sovereignty is freedom as non-interference. A sovereign state is consequently a state that is free from, i.e. not interfered with by, external actors like, for example, the EU. Put differently, either the EU is sovereign or the Member States are sovereign. By shifting the perspective to a neo-Roman republican understanding of freedom as non-domination the constitutional picture of the EU will become more nuanced. Res publica is best understood as what citizens hold in common and above their narrow self-interest. According to a republican notion of the constitution the purpose of the law is to eliminate the possibility of arbitrary domination. For that reason, not all interference is to be considered as a restriction of freedom but only those restrictions that cannot be justified according to the res publica. Viewed through the republican prism it can be argued that the EU represents an important advancement in securing freedom as non-domination without implying that the EU must become a state. The fundamental enigma can thus be rephrased as a clash between two diverging concepts of freedom. Whereas the EU will always be at odds with the idea of sovereignty (however framed it will be much easier to reconcile with the republican ideal. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=1837332

  9. PHENOstruct: Prediction of human phenotype ontology terms using heterogeneous data sources [v1; ref status: indexed, http://f1000r.es/5j2

    Directory of Open Access Journals (Sweden)

    Indika Kahanda

    2015-07-01

    Full Text Available The human phenotype ontology (HPO was recently developed as a standardized vocabulary for describing the phenotype abnormalities associated with human diseases. At present, only a small fraction of human protein coding genes have HPO annotations. But, researchers believe that a large portion of currently unannotated genes are related to disease phenotypes. Therefore, it is important to predict gene-HPO term associations using accurate computational methods. In this work we demonstrate the performance advantage of the structured SVM approach which was shown to be highly effective for Gene Ontology term prediction in comparison to several baseline methods. Furthermore, we highlight a collection of informative data sources suitable for the problem of predicting gene-HPO associations, including large scale literature mining data.

  10. JSim, an open-source modeling system for data analysis [v2; ref status: indexed, http://f1000r.es/39h

    Directory of Open Access Journals (Sweden)

    Erik Butterworth

    2014-05-01

    open source; it and about 400 human readable open source physiological/biophysical models are available at http://www.physiome.org/jsim/.

  11. JSim, an open-source modeling system for data analysis [v1; ref status: indexed, http://f1000r.es/2fk

    Directory of Open Access Journals (Sweden)

    Erik Butterworth

    2013-12-01

    open source; it and about 400 human readable open source physiological/biophysical models are available at http://www.physiome.org/jsim/.

  12. JSim, an open-source modeling system for data analysis [v3; ref status: indexed, http://f1000r.es/3n0

    Directory of Open Access Journals (Sweden)

    Erik Butterworth

    2014-07-01

    open source; it and about 400 human readable open source physiological/biophysical models are available at http://www.physiome.org/jsim/.

  13. Res Publica objedinjajetsja s Sojuzom Otetshestva

    Index Scriptorium Estoniae

    2006-01-01

    Res Publica ja Isamaaliidu liitumisel tekib uus erakond - Eesti Eest!. Ida-Viru Isamaaliidu ja Res Publica esimeeste Hans Pindre, Vladislav Ponjatovski ning Narva Res Publica endise liidri Nikolai Golubevi arvamused

  14. Hypoglycemic depression of RES function.

    Science.gov (United States)

    Buchanan, B J; Filkins, J P

    1976-07-01

    The intravascular removal rates of colloidal carbon and of biologically active endotoxin by the reticuloendothelial system (RES) were evaluated as a function of blood-glucose levels. There was a significant negative correlation of carbon clearance half time on blood glucose in both saline-treated and insulin-treated rats. Insulin hypoglycemia depressed RES carbon clearance with the maximal effect occurring at blood glucose values below 30 mg/dl. Insulin hypoglycemia also severely impaired the intravascular removal of endotoxin as evaluated by lethality bioassay in lead-sensitized rats. It is concluded that blood glucose may modulate RES phagocytic function and that the hypoglycemia of endotoxin shock may augment the shock state due to impairment of RES host defense clearance functions.

  15. Variability Study between Pap Smear, Colposcopy and Cervical Histopathology Findings

    International Nuclear Information System (INIS)

    Akhter, S.; Bari, A.; Hayat, Z.

    2015-01-01

    Objective: To determine the agreement/variability between colposcopic findings, Pap smear cytology and histopathological diagnosis in gynaecology patients. Methods: The cross-sectional cohort study was conducted from October 2010 to September 2011 at the Fauji Foundation Hospital, Rawalpindi, and comprised women who presented to the out-patient department with various gynaecological complaints. Colposcopy was performed in all women with unhealthy cervix during gynaecological examination, abnormal Pap smear report, recurrent vaginal discharge and postcoital bleeding. Pap smear was performed before colposcopy if not done earlier. Colposcopic findings were recorded on a specially-designed proforma. Biopsies from abnormal areas were taken and sent for histopathology. Colposcopic findings were compared with histopathology and Pap smear reports The agreement between the methods was evaluated by using Kappa coefficient and chi square test at a significance level of 5 percent. Results: The mean age of the 143 women was 44 8.5 years (range: 25-72 years). Colposcopic findings were normal in 66(46 percent) women, while 77(54 percent) had abnormal findings and among the latter, 62(80.5 percent) had abnormal histopathology, indicating strong agreement (K=0.65; p<0.001). Pap smear report was abnormal in 48(33.5 percent) cases and among them histopathology was abnormal in 28(58 percent). In the remaining 95(66.4 percent) patients with normal Pap smear, histopathology was abnormal in 44((46 percent), indicating weak agreement between Pap smear and histopathological diagnosis (K=0.10; p=0.08). Conclusion: There was a strong agreement between colposcopic findings and histopathological diagnosis. However, agreement between cytological findings and colposcopic findings and cytology and histopathological diagnosis remained weak. (author)

  16. Arabidopsis AtPAP1 transcription factor induces anthocyanin production in transgenic Taraxacum brevicorniculatum.

    Science.gov (United States)

    Qiu, Jian; Sun, Shuquan; Luo, Shiqiao; Zhang, Jichuan; Xiao, Xianzhou; Zhang, Liqun; Wang, Feng; Liu, Shizhong

    2014-04-01

    This study developed a new purple coloured Taraxacum brevicorniculatum plant through genetic transformation using the Arabidopsis AtPAP1 gene, which overproduced anthocyanins in its vegetative tissues. Rubber-producing Taraxacum plants synthesise high-quality natural rubber (NR) in their roots and so are a promising alternative global source of this raw material. A major factor in its commercialization is the need for multipurpose exploitation of the whole plant. To add value to the aerial tissues, red/purple plants of the rubber-producing Taraxacum brevicorniculatum species were developed through heterologous expression of the production of anthocyanin pigment 1 (AtPAP1) transcription factor from Arabidopsis thaliana. The vegetative tissue of the transgenic plants showed an average of a 48-fold increase in total anthocyanin content over control levels, but with the exception of pigmentation, the transgenic plants were phenotypically comparable to controls and displayed similar growth vigor. Southern blot analysis confirmed that the AtPAP1 gene had been integrated into the genome of the high anthocyanin Taraxacum plants. The AtPAP1 expression levels were estimated by quantitative real-time PCR and were highly correlated with the levels of total anthocyanins in five independent transgenic lines. High levels of three cyanidin glycosides found in the purple plants were characterized by high performance liquid chromatography-mass spectrum analysis. The presence of NR was verified by NMR and infrared spectroscopy, and confirmed that NR biosynthesis had not been affected in the transgenic Taraxacum lines. In addition, other major phenylpropanoid products such as chlorogenic acid and quercetin glycosides were also enhanced in the transgenic Taraxacum. The red/purple transgenic Taraxacum lines described in this study would increase the future application of the species as a rubber-producing crop due to its additional health benefits.

  17. The progress of RES environment in the most recent member states of the EU

    Energy Technology Data Exchange (ETDEWEB)

    Patlitzianas, Konstantinos [Management and Decision Support Systems Lab (EPU-NTUA), School of Electrical and Computer Engineering, National Technical University of Athens, 9, Iroon Polytechniou str., 15773, Athens (Greece); Karagounis, Konstantinos [National and Kapodistrian University of Athens, Dental School, 2 Thivon Str., Goudi, 11527 Athens (Greece)

    2011-02-15

    The most recent EU member states seem to have important Renewable Energy Sources (RES) potential. However, they have serious structural difficulties in development and integration of RES policies. Indeed, the balanced development of RES between the member states is urgent today. The penetration of the RES in these member states is related to the existence of an appropriate environment (political, economical, social, and technological). The current paper is based on an analytical review and specific PEST analysis aiming to assess the current RES environment and the progress so far in each of these most recent EU members. (author)

  18. Cervical pap smear- A prospective study in a tertiary hospital

    Directory of Open Access Journals (Sweden)

    S Pudasaini

    2015-09-01

    Full Text Available Background: Cervical cancer is a leading cause of mortality and morbidity among women worldwide and most common gynaecological cancer in developing countries. Papanicolaou smear is a simple and cost effective screening test for cervical cancer. The aim of this study is to evaluate and interpret the cervical pap smear cytology in a tertiary hospital. The interpretation and reporting of the pap smear is based on 2001Bethesda system.Materials and methods: This is a prospective study conducted in a tertiary hospital, Nepal Medical College over a period of two and a half years (January 2013 to June 2015. All cervical pap smears received in the department of Pathology in the study period were included.Results: A total of 4160 cervical pap smears were reported in the study period. Majority of the cases were Negative for Intraepithelial lesion or malignancy (87.9%. Bacterial vaginosis, atrophy and reactive cellular changes associated with inflammation were seen in 5.3%, 2.4% and 1.5% cases respectively.   Epithelial cell abnormalities (0.5% include Atypical squamous cells of undetermined significance, Low grade squamous intraepithelial lesion and High grade intraepithelial lesion. 88% of Low grade squamous intraepithelial lesion was seen in reproductive age group (20-45 years.Conclusion: Cervical cancer is the most common gynaecological cancer in the developing countries. Pap smear is the simple and cost effective screening tool to detect pre invasive cervical epithelial lesions.

  19. Res Publica v respublike / Roman Gornev

    Index Scriptorium Estoniae

    Gornev, Roman

    2002-01-01

    Järg 29. november nr. 48 lk. 7. Res Publica - uue poliitika partei. Res Publica Ida-Virumaal, partei juhtfiguurid, Res Publica Kohtla-Järvel. Koalitsioonileping Keskerakonnaga viis konfliktini partei juhtkonnaga. Kohtla-Järve Res Publica kohaliku organisatsiooni konflikti partei juhtkonnaga kommenteerib Hants Hint

  20. Res Publica kogub uut hoogu / Andres Jalak

    Index Scriptorium Estoniae

    Jalak, Andres, 1953-

    2005-01-01

    Kommenteerides Res Publica senise esimehe ja endise peaministri Juhan Partsi ning uueks esimeheks valitud Taavi Veskimäe kõnet Res Publica üldkogul, väljendab Res Publica fraktsiooni aseesimees usku, et Res Publica juhtimisel suudetakse 2007. aasta parlamendivalimistel taastada tulevikku suunatud mõtlemisega valitsus

  1. Effect of Physician Gender on Demand for Pap Tests

    OpenAIRE

    Lin, Tsui-Fang; Chen, Jennjou

    2014-01-01

    People’s demand for preventive medical care is one type of investment in health. The aim of this paper is to examine women’s demand for secondary prevention in Taiwan, focusing on the role a physician’s gender plays in women’s inclination to undergo Pap tests. Our estimation results show that regional ratio of female doctors has a positive and significant effect on utilization of Pap tests for the full sample and for women aged below 30. In addition, doctor’s gender matters only in utilizatio...

  2. BioMagResBank.

    NARCIS (Netherlands)

    Ulrich, E.L.; Akutsu, H.; Doreleijers, J.; Harano, Y.; Ioannidis, Y.E.; Lin, J.; Livny, M.; Mading, S.; Maziuk, D.; Miller, Z.; Nakatani, E.; Schulte, C.F.; Tolmie, D.E.; Wenger, R.K.; Yao, H.; Markley, J.L.

    2008-01-01

    The BioMagResBank (BMRB: www.bmrb.wisc.edu) is a repository for experimental and derived data gathered from nuclear magnetic resonance (NMR) spectroscopic studies of biological molecules. BMRB is a partner in the Worldwide Protein Data Bank (wwPDB). The BMRB archive consists of four main data

  3. Resúmenes Conferencias Magistrales

    Directory of Open Access Journals (Sweden)

    Editor Gabriel Vargas Arana

    2015-12-01

    Full Text Available En este artículo se pueden encontrar los resúmenes de las conferencias magistrales del III Congreso Latinoamericano de Plantas Medicinales, desarrollado del 12 al 14 de agosto de 2015 en la ciudad de Iquitos, Perú.

  4. Resúmenes Presentaciones Orales

    Directory of Open Access Journals (Sweden)

    Editor Gabriel Vargas Arana

    2015-12-01

    Full Text Available En este artículo se pueden encontrar los resúmenes de las presentaciones orales del III Congreso Latinoamericano de Plantas Medicinales, desarrollado del 12 al 14 de agosto de 2015 en la ciudad de Iquitos, Perú.

  5. RES: Regularized Stochastic BFGS Algorithm

    Science.gov (United States)

    Mokhtari, Aryan; Ribeiro, Alejandro

    2014-12-01

    RES, a regularized stochastic version of the Broyden-Fletcher-Goldfarb-Shanno (BFGS) quasi-Newton method is proposed to solve convex optimization problems with stochastic objectives. The use of stochastic gradient descent algorithms is widespread, but the number of iterations required to approximate optimal arguments can be prohibitive in high dimensional problems. Application of second order methods, on the other hand, is impracticable because computation of objective function Hessian inverses incurs excessive computational cost. BFGS modifies gradient descent by introducing a Hessian approximation matrix computed from finite gradient differences. RES utilizes stochastic gradients in lieu of deterministic gradients for both, the determination of descent directions and the approximation of the objective function's curvature. Since stochastic gradients can be computed at manageable computational cost RES is realizable and retains the convergence rate advantages of its deterministic counterparts. Convergence results show that lower and upper bounds on the Hessian egeinvalues of the sample functions are sufficient to guarantee convergence to optimal arguments. Numerical experiments showcase reductions in convergence time relative to stochastic gradient descent algorithms and non-regularized stochastic versions of BFGS. An application of RES to the implementation of support vector machines is developed.

  6. Papshop: Not a 'melon'choly Pap smear workshop!

    African Journals Online (AJOL)

    of cervical cancer will take several decades to be apparent. There are more effective ways of screening, such as HPV DNA testing,[2] ... ARTICLE. Papshop: Not a 'melon'choly Pap smear workshop! C Gordon, MB ChB, Diploma in HIV ...

  7. Missed Opportunities for Health Education on Pap Smears in Peru

    Science.gov (United States)

    Bayer, Angela M.; Nussbaum, Lauren; Cabrera, Lilia; Paz-Soldan, Valerie A.

    2011-01-01

    Despite cervical cancer being one of the leading causes of cancer-related deaths among women in Peru, cervical Pap smear coverage is low. This article uses findings from 185 direct clinician observations in four cities of Peru (representing the capital and each of the three main geographic regions of the country) to assess missed opportunities for…

  8. Pap-smear Benchmark Data For Pattern Classification

    DEFF Research Database (Denmark)

    Jantzen, Jan; Norup, Jonas; Dounias, Georgios

    2005-01-01

    This case study provides data and a baseline for comparing classification methods. The data consists of 917 images of Pap-smear cells, classified carefully by cyto-technicians and doctors. Each cell is described by 20 numerical features, and the cells fall into 7 classes. A basic data analysis in...

  9. Evaluation of Antibiotic Resistance and Detection of papC and papG genes in Escherichia coli Strains Isolated from Patients with Urinary Tract Infection

    Directory of Open Access Journals (Sweden)

    Mitra Alishah

    2016-11-01

    Full Text Available Abstract Background and Objectives: Escherichia coli is the most common etiologic factor of urinary tract infection, which its most important virulence factor is P fimbriae. Uropathogenic E. coli expresses various types of adhesins, such as pili adhesins (pyelonephritis-associated pili, Pap that mediates binding to the surface of epithelial cells of the urinary tract. This study aims to identify papC and papG genes and to evaluate antibiotic resistance level in the isolated E. coli samples. Methods: In this descriptive cross-sectional study, 50 samples were collected from patients with urinary tract infection and after isolation of bacteria and DNA extraction, antibiotic susceptibility tests was performed by disc diffusion method using related antibiotics. Presence of papG and papC genes (class I, II, and III was assessed by multiplex PCR method. Statistical data were analyzed using descriptive t-test. Results: The isolated E. coli samples were susceptible to amikacin (100% and cefepime (72% and resistant to ampicillin (100% and nitrofurantoin (94%. Eighteen samples (32.7% had papG gene, of which 17 (30.9% samples had papGII gene and 1 sample (1.8% had papGIII gene; papGI gene was not detected in any of the samples. Conclusion: The results of the present study showed that papC and papGI genes are the most common Pap fimbriae adhesion-encoding genes in E. coli isolated from urinary tract infection. The difference between the results of this study with those of other studies is due to geographic diversity. Keywords: Escherichia coli; Adhesion pap, Disk diffusion antimicrobial tests; Multiplex polymerase chain reaction.

  10. Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland

    Energy Technology Data Exchange (ETDEWEB)

    Konishi, Hiroyuki, E-mail: konishi@med.osaka-cu.ac.jp [Department of Anatomy and Neurobiology, Osaka City University Graduate School of Medicine, Osaka (Japan); The 21st Century COE Program ' Base to Overcome Fatigue' , Osaka City University Graduate School of Medicine, Osaka (Japan); Department of Anatomy and Neuroscience, Nagoya University, Graduate School of Medicine, Nagoya (Japan); Ogawa, Tokiko, E-mail: togawa@med.osaka-cu.ac.jp [Department of Anatomy and Neurobiology, Osaka City University Graduate School of Medicine, Osaka (Japan); The 21st Century COE Program ' Base to Overcome Fatigue' , Osaka City University Graduate School of Medicine, Osaka (Japan); Kawahara, Shinichi, E-mail: kawahara@med.osaka-cu.ac.jp [Department of Anatomy and Neurobiology, Osaka City University Graduate School of Medicine, Osaka (Japan); Matsumoto, Sakiko, E-mail: s-matsumoto@med.osaka-cu.ac.jp [Department of Anatomy and Neurobiology, Osaka City University Graduate School of Medicine, Osaka (Japan); Department of Anatomy and Neuroscience, Nagoya University, Graduate School of Medicine, Nagoya (Japan); Kiyama, Hiroshi, E-mail: kiyama@med.osaka-cu.ac.jp [Department of Anatomy and Neurobiology, Osaka City University Graduate School of Medicine, Osaka (Japan); The 21st Century COE Program ' Base to Overcome Fatigue' , Osaka City University Graduate School of Medicine, Osaka (Japan); Department of Anatomy and Neuroscience, Nagoya University, Graduate School of Medicine, Nagoya (Japan)

    2011-04-01

    Research highlights: {yields} We focused on the rat pituitary intermediate lobe (IL) under continuous stress (CS). {yields} CS induced PAP-I and PAP-II expression in melanotrophs of the IL. {yields} This gene induction was triggered by CS-related dopamine dysregulation. {yields} PAP-I and PAP-II may sustain homeostasis of the IL under CS. -- Abstract: Under continuous stress (CS) in rats, melanotrophs, the predominant cell-type in the intermediate lobe (IL) of the pituitary, are hyperactivated to secrete {alpha}-melanocyte-stimulating hormone and thereafter degenerate. Although these phenomena are drastic, the molecular mechanisms underlying the cellular changes are mostly unknown. In this study, we focused on the pancreatitis-associated protein (PAP) family members of the secretory lectins and characterized their expression in the IL of CS model rats because we had identified two members of this family as up-regulated genes in our previous microarray analysis. RT-PCR and histological studies demonstrated that prominent PAP-I and PAP-II expression was induced in melanotrophs in the early stages of CS, while another family member, PAP-III, was not expressed. We further examined the regulatory mechanisms of PAP-I and PAP-II expression and revealed that both were induced by the decreased dopamine levels in the IL under CS. Because the PAP family members are implicated in cell survival and proliferation, PAP-I and PAP-II secreted from melanotrophs may function to sustain homeostasis of the IL under CS conditions in an autocrine or a paracrine manner.

  11. Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland

    International Nuclear Information System (INIS)

    Konishi, Hiroyuki; Ogawa, Tokiko; Kawahara, Shinichi; Matsumoto, Sakiko; Kiyama, Hiroshi

    2011-01-01

    Research highlights: → We focused on the rat pituitary intermediate lobe (IL) under continuous stress (CS). → CS induced PAP-I and PAP-II expression in melanotrophs of the IL. → This gene induction was triggered by CS-related dopamine dysregulation. → PAP-I and PAP-II may sustain homeostasis of the IL under CS. -- Abstract: Under continuous stress (CS) in rats, melanotrophs, the predominant cell-type in the intermediate lobe (IL) of the pituitary, are hyperactivated to secrete α-melanocyte-stimulating hormone and thereafter degenerate. Although these phenomena are drastic, the molecular mechanisms underlying the cellular changes are mostly unknown. In this study, we focused on the pancreatitis-associated protein (PAP) family members of the secretory lectins and characterized their expression in the IL of CS model rats because we had identified two members of this family as up-regulated genes in our previous microarray analysis. RT-PCR and histological studies demonstrated that prominent PAP-I and PAP-II expression was induced in melanotrophs in the early stages of CS, while another family member, PAP-III, was not expressed. We further examined the regulatory mechanisms of PAP-I and PAP-II expression and revealed that both were induced by the decreased dopamine levels in the IL under CS. Because the PAP family members are implicated in cell survival and proliferation, PAP-I and PAP-II secreted from melanotrophs may function to sustain homeostasis of the IL under CS conditions in an autocrine or a paracrine manner.

  12. CKI isoforms α and ε regulate Star–PAP target messages by controlling Star–PAP poly(A) polymerase activity and phosphoinositide stimulation

    Science.gov (United States)

    Laishram, Rakesh S.; Barlow, Christy A.; Anderson, Richard A.

    2011-01-01

    Star–PAP is a non-canonical, nuclear poly(A) polymerase (PAP) that is regulated by the lipid signaling molecule phosphatidylinositol 4,5 bisphosphate (PI4,5P2), and is required for the expression of a select set of mRNAs. It was previously reported that a PI4,5P2 sensitive CKI isoform, CKIα associates with and phosphorylates Star–PAP in its catalytic domain. Here, we show that the oxidative stress-induced by tBHQ treatment stimulates the CKI mediated phosphorylation of Star–PAP, which is critical for both its polyadenylation activity and stimulation by PI4,5P2. CKI activity was required for the expression and efficient 3′-end processing of its target mRNAs in vivo as well as the polyadenylation activity of Star–PAP in vitro. Specific CKI activity inhibitors (IC261 and CKI7) block in vivo Star–PAP activity, but the knockdown of CKIα did not equivalently inhibit the expression of Star–PAP targets. We show that in addition to CKIα, Star–PAP associates with another CKI isoform, CKIε in the Star–PAP complex that phosphorylates Star–PAP and complements the loss of CKIα. Knockdown of both CKI isoforms (α and ε) resulted in the loss of expression and the 3′-end processing of Star–PAP targets similar to the CKI activity inhibitors. Our results demonstrate that CKI isoforms α and ε modulate Star–PAP activity and regulates Star–PAP target messages. PMID:21729869

  13. Mida ootame Res Publica poliitikutelt? / Andreas Kaju

    Index Scriptorium Estoniae

    Kaju, Andreas

    2003-01-01

    Res Publica Juventus on piirkondadele saadetud küsitlustega otsinud vastuseid mitmetele probleemidele. Eesmärk Res Publica poliitilise käitumise raamide määramine. Tabel: Juventuse küsimused piirkondadele

  14. Rahvaliit likvideerib Res Publica veeuputust / Janno Reiljan

    Index Scriptorium Estoniae

    Reiljan, Janno, 1951-2018

    2005-01-01

    Ilmunud ka: Molodjozh Estonii 1. august lk. 5. Selgitused Res Publica esimehe Taavi Veskimägi artiklile 25. juuli Postimehes "Pärast meid tulgu või veeuputus". Res Publica ja Rahvaliidu poliitika võrdlus

  15. Miks Res Publica kaotas / Juhan Parts

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2004-01-01

    Ilmunud ka: Severnoje Poberezhje, 29. juuni 2004, lk. 2; Koit, 29. juuni 2004, lk. 6. Europarlamendi valimiste tulemused erakonnale Res Publica. Juhan Partsi kõne 26. juunil Pärnus toimunud Res Publica volikogul. Lühendatult

  16. Padenije Res Publica / Viktoria Jürmann

    Index Scriptorium Estoniae

    Jürmann, Viktoria

    2005-01-01

    Res Publica üks rajajatest, Rein Taagepera, lahkus parteist, süüdistades erakonda paremtsentristlikust maailmavaatest loobumises. Res Publica Riigikogu fraktsioon tahab avaldada umbusaldust haridus- ja teadusminister Mailis Repsile

  17. Res Publica esitas avalduse kaposse / Virkko Lepassalu

    Index Scriptorium Estoniae

    Lepassalu, Virkko, 1971-

    2003-01-01

    Kaposse jõudis Res Publica avaldus, milles palutakse uurida erakonda seadusvastaselt anonüümselt sponsoreerima kutsuva kirja tagamaid. Vt. ka Äripäev 19. veebruar lk. 6 "Kapo ei alustanud Res Publica avalduse peale kriminaalmenetlust"

  18. Rein Taagepera lahkub Res Publicast / Kristjan Roos

    Index Scriptorium Estoniae

    Roos, Kristjan, 1978-

    2005-01-01

    Res Publica asutaja Rein Taagepera, Jaan Einasto, Mare Taagepera ja Lauri Aaspõllu lahkuvad Res Publicast, kuna erakond on nende väitel muutunud paremtsentrist paremäärmuslikuks. Vt. samas: Erakonnad hoiavad uksed valla

  19. 10 teesi Res Publica valitsemisprogrammist aastani 2007

    Index Scriptorium Estoniae

    2004-01-01

    Ilmunud ka: Ottshjot narodu Estonii. Res Publica 2003, 2004, lk. 4-5, 8-9. Res Publica valitsemisprogrammi lubadustest ja täitmisest. Vt. lk. 8-9 Res Publica ministrite olulisemad tegevused 2004. aastal - lühiülevaate teevad Ken-Marti Vaher, Taavi Veskimägi, Marko Pomerants, Toivo Maimets

  20. Identification of Proteins and Peptide Biomarkers for Detecting Banned Processed Animal Proteins (PAPs) in Meat and Bone Meal by Mass Spectrometry.

    Science.gov (United States)

    Marbaix, Hélène; Budinger, Dimitri; Dieu, Marc; Fumière, Olivier; Gillard, Nathalie; Delahaut, Philippe; Mauro, Sergio; Raes, Martine

    2016-03-23

    The outbreak of bovine spongiform encephalopathy (BSE) in the United Kingdom in 1986, with processed animal proteins (PAPs) as the main vector of the disease, has led to their prohibition in feed. The progressive release of the feed ban required the development of new analytical methods to determine the exact origin of PAPs from meat and bone meal. We set up a promising MS-based method to determine the species and the source (legal or not) present in PAPs: a TCA-acetone protein extraction followed by a cleanup step, an in-solution tryptic digestion of 5 h (with a 1:20 protein/trypsin ratio), and mass spectrometry analyses, first without any a priori, with a Q-TOF, followed by a targeted triple-quadrupole analysis. Using this procedure, we were able to overcome some of the major limitations of the official methods to analyze PAPs, detecting and identifying prohibited animal products in feedstuffs by the monitoring of peptides specific for cows, pigs, and sheep in PAPs.

  1. Cytomorphology of unusual infectious entities in the Pap test

    Directory of Open Access Journals (Sweden)

    Walid E Khalbuss

    2012-01-01

    Full Text Available Rare entities in the Pap test, including neoplastic and non-neoplastic conditions, pose challenges due to their infrequent occurrence in the daily practice of cytology. Furthermore, these conditions give rise to important diagnostic pitfalls. Infections such as tuberculosis cervicitis may be erroneously diagnosed as carcinoma, whereas others, such as schistosomiasis, are associated with squamous cell carcinoma. These cases include granuloma inguinale (donovanosis, tuberculosis, coccidioidomycosis, schistosomiasis, taeniasis, and molluscum contagiosum diagnosed in Pap tests. Granuloma inguinale shows histiocytes that contain intracytoplasmic bacteria (Donovan bodies. Tuberculosis is characterized by necrotizing granulomatous inflammation with Langhans-multinucleated giant cells. Coccidioidomycosis may show large intact or ruptured fungal spherules associated with endospores. Schistosoma haematobium is diagnosed by finding characteristic ova with a terminal spine. Molluscum contagiosum is characterized by the appearance of squamous cells with molluscum bodies. This article reviews the cytomorphology of selected rare infections and focuses on their cytomorphology, differential diagnosis, and role of ancillary diagnostic studies.

  2. Papéis de imprimir e escrever

    OpenAIRE

    Mattos, René Luiz Grion; Valença, Antonio Carlos de Vasconcelos

    2001-01-01

    Este trabalho analisa o comportamento recente da produção, do consumo e da comercialização de papéis de imprimir e escrever no Brasil e no mundo. Em sua parte final mostra as perspectivas de curto prazo do mercado mundial e do Brasil, que apontam para a necessidade de implantação de duas grandes novas máquinas produtoras de papel de imprimir e escrever.

  3. Rate of Opportunistic Pap Smear Screening and Patterns of Epithelial Cell Abnormalities in Pap Smears in Ajman, United Arab Emirates

    Science.gov (United States)

    Al Eyd, Ghaith J.; Shaik, Rizwana B.

    2012-01-01

    Objectives: The aim of this study was to estimate the proportion of women undergoing Papanicolaou (Pap) smear examinations, and the frequency of epithelial cell abnormalities in a teaching hospital in one emirate of the United Arab Emirates (UAE) during a three-year period. Methods: A retrospective study of 602 patient records from July 2007 to July 2010 was done in a teaching hospital in Ajman, UAE. The variables studied were age, ethnicity, menopausal status, and abnormalities in the Pap smear. Data were analysed using the Statistical Package for the Social Sciences and presented mainly as percentages; to assess associations, the chi-square test was used. Results: The total number of outpatients who attended the Obstetrics & Gynaecology Department from July 2007 to July 2010 was 150,111 patients, of which 602 (0.4% of the total) had a Pap smear test. The sample was 50.1% Arabs and 49.9% other nationalities. While 73% of the outpatients had specific complaints, 27% came for a routine screening. Epithelial cell abnormalities were seen in 3.3% of the sample, with atypical squamous cells of undetermined significance (ASCUS) found in 1.8%, low-grade squamous intraepithelial lesions (LSILs) found in 1.2%, and high-grade squamous intraepithelial lesions (HSILs) found in 0.3%. There were no cases of squamous cell carcinoma. Conclusion: Voluntary routine Pap smear screening was remarkably low in the study group. ASCUS was the most common epithelial cell abnormality. Community health education and opportunistic screening for cervical cancer are recommended for both national and expatriate women in the region. PMID:23275844

  4. Rate of Opportunistic Pap Smear Screening and Patterns of Epithelial Cell Abnormalities in Pap Smears in Ajman, United Arab Emirates

    Directory of Open Access Journals (Sweden)

    Rizwana B. Shaik

    2012-11-01

    Full Text Available Objectives: The aim of this study was to estimate the proportion of women undergoing Papanicolaou (Pap smear examinations, and the frequency of epithelial cell abnormalities in a teaching hospital in one emirate of the United Arab Emirates (UAE during a three-year period. Methods: A retrospective study of 602 patient records from July 2007 to July 2010 was done in a teaching hospital in Ajman, UAE. The variables studied were age, ethnicity, menopausal status, and abnormalities in the Pap smear. Data were analysed using the Statistical Package for the Social Sciences and presented mainly as percentages; to assess associations, the chi-square test was used. Results: The total number of outpatients who attended the Obstetrics & Gynaecology Department from July 2007 to July 2010 was 150,111 patients, of which 602 (0.4% of the total had a Pap smear test. The sample was 50.1% Arabs and 49.9% other nationalities. While 73% of the outpatients had specific complaints, 27% came for a routine screening. Epithelial cell abnormalities were seen in 3.3% of the sample, with atypical squamous cells of undetermined significance (ASCUS found in 1.8%, low-grade squamous intraepithelial lesions (LSILs found in 1.2%, and high-grade squamous intraepithelial lesions (HSILs found in 0.3%. There were no cases of squamous cell carcinoma. Conclusion: Voluntary routine Pap smear screening was remarkably low in the study group. ASCUS was the most common epithelial cell abnormality. Community health education and opportunistic screening for cervical cancer are recommended for both national and expatriate women in the region.

  5. Suitability of peanut residue as a nitrogen source for a rye cover crop Resíduos da cultura de amendoim como fonte de nitrogênio para uma cultura de cobertura de centeio

    Directory of Open Access Journals (Sweden)

    Kipling Shane Balkcom

    2007-01-01

    Full Text Available Leguminous winter cover crops have been utilized in conservation systems to partially meet nitrogen (N requirements of succeeding summer cash crops, but the potential of summer legumes to reduce N requirements of a winter annual grass, used as a cover crop, has not been extensively examined. This study assessed the N contribution of peanut (Arachis hypogaea L. residues to a subsequent rye (Secale cereale L. cover crop grown in a conservation system on a Dothan sandy loam (fine-loamy, kaolinitic, thermic Plinthic Kandiudults at Headland, AL USA during the 2003-2005 growing seasons. Treatments were arranged in a split plot design, with main plots of peanut residue retained or removed from the soil surface, and subplots as N application rates (0, 34, 67 and 101 kg ha-1 applied in the fall. Peanut residue had minimal to no effect on rye biomass yields, N content, carbon (C /N ratio, or N, P, K, Ca and Zn uptake. Additional N increased rye biomass yield, and N, P, K, Ca, and Zn uptakes. Peanut residue does not contribute significant amounts of N to a rye cover crop grown as part of a conservation system, but retaining peanut residue on the soil surface could protect the soil from erosion early in the fall and winter before a rye cover crop grows sufficiently to protect the typically degraded southeastern USA soils.Culturas leguminosas de inverno tem sido utilizadas em sistemas conservacionistas para suprimento parcial das necessidades de nitrogênio (N de culturas subseqüentes de verão, mas o potencial destas culturas leguminosas de verão no sentido de reduzir as necessidades de N de gramíneas anuais de inverno, utilizadas como culturas de cobertura, ainda não foi extensivamente estudado. Este trabalho avaliou a contribuição dos resíduos de uma cultura de amendoim (Arachis hypogaea L. sobre as necessidades de N de uma cultura subsequente de centeio (Secale cereale L. como cobertura desenvolvida dentro de um sistema conservacionista, em um

  6. Estimation of Pap-test coverage in an area with an organised screening program: challenges for survey methods

    Directory of Open Access Journals (Sweden)

    Raggi Patrizio

    2006-03-01

    Full Text Available Abstract Background The cytological screening programme of Viterbo has completed the second round of invitations to the entire target population (age 25–64. From a public health perspective, it is important to know the Pap-test coverage rate and the use of opportunistic screening. The most commonly used study design is the survey, but the validity of self-reports and the assumptions made about non respondents are often questioned. Methods From the target population, 940 women were sampled, and responded to a telephone interview about Pap-test utilisation. The answers were compared with the screening program registry; comparing the dates of Pap-tests reported by both sources. Sensitivity analyses were performed for coverage over a 36-month period, according to various assumptions regarding non respondents. Results The response rate was 68%. The coverage over 36 months was 86.4% if we assume that non respondents had the same coverage as respondents, 66% if we assume they were not covered at all, and 74.6% if we adjust for screening compliance in the non respondents. The sensitivity and specificity of the question, "have you ever had a Pap test with the screening programme" were 84.5% and 82.2% respectively. The test dates reported in the interview tended to be more recent than those reported in the registry, but 68% were within 12 months of each other. Conclusion Surveys are useful tools to understand the effectiveness of a screening programme and women's self-report was sufficiently reliable in our setting, but the coverage estimates were strongly influenced by the assumptions we made regarding non respondents.

  7. Modifying and Pilot Testing the Pap Smear Belief Questionnaire

    Directory of Open Access Journals (Sweden)

    Kelly Ackerson

    2014-12-01

    Full Text Available This study is a report on modifications and pilot testing of a measurement tool to predict Pap testing based on the Interaction Model of Client Health Behavior. Women have been found to avoid routine cervical cancer screening (CCS due to personal influencing factors. For this study, the Pap Smear Belief Questionnaire (PSBQ was modified by adding items and evaluated through content validity index (CVI = .89 and cognitive interviews (think-aloud protocol, resulting in a 31-item instrument with four subscales (Benefits, Barriers, Vulnerability, Experiences. Pilot testing the modified PSBQ was conducted at a local agency. Fifty-three women completed and returned the PSBQ, which had good internal consistency, with a Cronbach’s alpha coefficient of .81 (Benefits α = .51; Barriers α = .85; Vulnerability α = .78; Experiences α = .87. Test–retest reliability of the 31-item PSBQ was also good (.878. Univariate logistic regression indicated that the only significant predictor of seeking/avoiding routine screening by women’s background characteristics was social influence (p = .04. Subscales found to be significant predictors in Pap testing were Barriers (p = .003 and Gynecological Exam Experiences (p = .04. The refined 31-item PSBQ has good psychometric data supporting its use in predicting CCS. However, this research should be replicated in a larger sample enabling further validity and reliability testing of the PSBQ. Understanding women’s attitudes toward CCS will help health care providers, who deal with gynecological health, develop more effective screening programs and interventions facilitating better experiences for women contributing to an increase in routine screening.

  8. Teine Res Musica ilmunud / Jaan Ross

    Index Scriptorium Estoniae

    Ross, Jaan, 1957-

    2010-01-01

    Artiklikogumikust: Res musica [2] : Eesti Muusikateaduse Seltsi ja Eesti Muusika- ja Teatriakadeemia muusikateaduse osakonna aastaraamat / peatoimetaja Urve Lippus. Tallinn : Eesti Muusika- ja Teatriakadeemia, 2010

  9. Adolescents with obstructive sleep apnea adhere poorly to positive airway pressure (PAP, but PAP users show improved attention and school performance.

    Directory of Open Access Journals (Sweden)

    Dean W Beebe

    2011-03-01

    Full Text Available Obstructive Sleep Apnea (OSA is associated with medical and neurobehavioral morbidity across the lifespan. Positive airway pressure (PAP treatment has demonstrated efficacy in treating OSA and has been shown to improve daytime functioning in adults, but treatment adherence can be problematic. There are nearly no published studies examining functional outcomes such as academic functioning in adolescents treated with PAP. This study was conducted as an initial step towards determining whether PAP treatment improves daytime functioning among adolescents with OSA.Self-reported academic grades, self- and parent-reported academic quality of life, and objectively-measured attention were assessed before and after PAP was clinically initiated in a sample of 13 obese adolescents with OSA, as well as 15 untreated obese Controls without OSA. Based on adherence data, the treated group was divided into PAP Users (n = 6 and Non-Adherent participants (n = 7.Though demographically similar, the three groups significantly differed in how their academic performance and attention scores changed from baseline to follow-up. Non-Adherent participants showed worsening functioning over time, while PAP Users showed stable or improved functioning, similar to controls.Although many adolescents prescribed PAP for OSA are non-adherent to the treatment, those who adhere to treatment can display improved attention and academic functioning.

  10. Crystal structure of the P pilus rod subunit PapA.

    Directory of Open Access Journals (Sweden)

    Denis Verger

    2007-05-01

    Full Text Available P pili are important adhesive fibres involved in kidney infection by uropathogenic Escherichia coli strains. P pili are assembled by the conserved chaperone-usher pathway, which involves the PapD chaperone and the PapC usher. During pilus assembly, subunits are incorporated into the growing fiber via the donor-strand exchange (DSE mechanism, whereby the chaperone's G1 beta-strand that complements the incomplete immunoglobulin-fold of each subunit is displaced by the N-terminal extension (Nte of an incoming subunit. P pili comprise a helical rod, a tip fibrillum, and an adhesin at the distal end. PapA is the rod subunit and is assembled into a superhelical right-handed structure. Here, we have solved the structure of a ternary complex of PapD bound to PapA through donor-strand complementation, itself bound to another PapA subunit through DSE. This structure provides insight into the structural basis of the DSE reaction involving this important pilus subunit. Using gel filtration chromatography and electron microscopy on a number of PapA Nte mutants, we establish that PapA differs in its mode of assembly compared with other Pap subunits, involving a much larger Nte that encompasses not only the DSE region of the Nte but also the region N-terminal to it.

  11. Frontières sociales, frontières culturelles, frontières techniques

    Directory of Open Access Journals (Sweden)

    2010-12-01

    Full Text Available Les sociétés démocratiques modernes ont basé leur unité sur l'égalité des chances et sur la mobilité sociale. Or, ce modèle d'intégration est fortement mis à l'épreuve aujourd'hui. Des discriminations structurelles viennent contredire le principe l'égalité de traitement. Des barrières difficilement franchissables, quel que soit le niveau, viennent contrecarrer la possibilité de promotion sociale. Un double phénomène est ainsi observable. D'une part, la société se fractionne en des espaces soc...

  12. Res Publica soolo rikkus tavasid / Kai Kalamees

    Index Scriptorium Estoniae

    Kalamees, Kai

    2005-01-01

    Riigikogu aseesimeheks valiti Res Publica liige Taavi Veskimägi, nüüd on Riigikogu juhatuses kaks ühe partei liiget. Riigikogu aseesimeheks tagasi valitud Toomas Vareki hinnangul näitab see samm nii Res Publica kogenematust kui ka Eesti poliitilise kultuuri kehva taset

  13. Res Publica otsib kandepinda / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2004-01-01

    Res Publica peasekretäri Ott Lumi sõnul on erakond teinud tõsised järeldused Euroopa Parlamendi valimiste tulemusest. Res Publica parlamendifraktsiooni väljasõidul pidas kriitilise kõne erakonna esimees Juhan Parts

  14. Isamaaliidu ühinemisjutt ajas Res Publica keema / Toomas Sildam

    Index Scriptorium Estoniae

    Sildam, Toomas, 1961-

    2005-01-01

    Ilmunud ka: Postimees : na russkom jazõke 14. nov., lk 3. Isamaaliidu esimehe Tõnis Lukase ettepanekut Isamaaliidu ja Res Publica ühinemiseks pooldavad ka Res Publica eestseisuse liikmed Juhan Parts ja Tõnis Palts, kuid Res Publica esimehe Taavi Veskimäe kinnitusel läheb Res Publica 2007. aasta parlamendivalimistele vastu iseseisvalt. Lisa: Isamaaliit ja Res Publica

  15. How Often to Get a Pap Test (A Cup of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2013-01-10

    Cervical cancer has declined in the U.S., and the decline is largely due to Pap testing and follow-up. Screening recommendations have changed. In this podcast, Meg Watson discusses Pap testing.  Created: 1/10/2013 by MMWR.   Date Released: 1/10/2013.

  16. Age distribution of abnormal pap smear in a secondary hospital in ...

    African Journals Online (AJOL)

    Age distribution of abnormal pap smear in a secondary hospital in south-west Nigeria. ... Objective: To determine the age distribution pattern of abnormal Paps smear in women in our environment in order to have a basis for the points of entry and exit for cervical cancer screening protocol. Materials and Method: In this ...

  17. [Cloning and sequencing of the papA gene from uropathogenic Escherichia coli 4030 strain].

    Science.gov (United States)

    Wu, Qinggang; Zhang, Jingping; Zhao, Chuncheng; Zhu, Jianguo

    2008-09-01

    Cloning and sequencing of the papA gene from uropathogenic Escherichia coli 4030 strain to investigate the differences of the sequences of the papA of UPEC4030 strain and the ones of related genes, in order to make whether or not it was a new genotype. Cloning and sequencing methods were used to analyze the sequence of the papA of UPEC4030 strain in comparison with related sequences. The sequence analysis of papA revealed a 722 bp gene and encode 192 amino acid polypeptide. The overall homology of the papA genes between UPEC4030 and the standard strains of ten F types were 36.11%-77.95% and 22.20%-78.34% at nucleotide and deduced amino acid levels. The homology between the sequence of the reverse primers and the corresponding sequence of UPEC4030 papA was 10%-66.67%. The results confirmed that UPEC4030 strain contained a novel papA variant. UPEC4030 strain could contain an unknown papA variant or the novel genotype. The pathogenic mechanism and epidemiology related need to be further studied.

  18. Roles of phagocytosis activating protein (PAP) in Aeromonas hydrophila infected Cyprinus carpio.

    Science.gov (United States)

    Wonglapsuwan, Monwadee; Kongmee, Pataraporn; Suanyuk, Naraid; Chotigeat, Wilaiwan

    2016-06-01

    Cyprinus carpio (koi) is one of the most popular ornamental fish. A major problem for C. carpio farming is bacterial infections especially by Aeromonas hydrophila. Previously studies had shown that the Phagocytosis Activating Protein (PAP) gene was involved in the innate immune response of animals. Therefore, we attempted to identify a role for the PAP gene in the immunology of C. carpio. The expression of the PAP was found in C. carpio whole blood and increased when the fish were stimulated by inactivated A. hydrophila. In addition, PAP-phMGFP DNA was injected as an immunostimulant. The survival rate and the phagocytic index were significantly increased in the A. hydrophila infected fish that received the PAP-phMGFP DNA immunostimulant. A chitosan-PAP-phMGFP nanoparticle was then developed and feeded into fish which infected with A. hydrophila. These fish had a significantly lower mortality rate than the control. Therefore, this research confirmed a key role for PAP in protection fish from bacterial infection and the chitosan-PAP-phMGFP nanoparticle could be a good prototype for fish immunostimulant in the future. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. The clinical value of serum PSA and PAP determinations in prostate cancer patients

    International Nuclear Information System (INIS)

    Zeng Lei; Yu Renbo; Du Guowei; Pang Baozhong

    2001-01-01

    Objective: To investigate the clinical value of serum PSA and PAP determinations in diagnosis of prostate cancer patients. Methods: The serum PSA and PAP levels of 98 prostate cancer patients, 45 prostate benign disease patients and 40 normal subjects were tested by IRMA. Results: The serum PSA and PAP levels of prostate cancer patients were significantly higher than those in prostate benign disease patients and normal controls (P < 0.01). The diagnostic sensitivity and specificity of serum PSA for prostate cancer were 93.9% and 93.3% respectively. The diagnostic sensitivity and specificity of serum PAP for prostate cancer were 71.4% and 91.1% respectively. Conclusion: The determination of serum PSA and PAP was of high clinical value for diagnosis of early prostate cancer. It could be used as an important reference parameter for the clinical staging, follow-up of treatment result and prediction of prognosis

  20. Access to Adequate Healthcare for Hmong Women: A Patient Navigation Program to Increase Pap Test Screening

    Directory of Open Access Journals (Sweden)

    Moon S. Chen, Jr

    2010-01-01

    Full Text Available This paper describes the development and implementation of a Hmong Cervical Cancer Intervention Program utilizing a patient navigation model to raise cervical cancer awareness for Hmong women through educational workshops and to assist Hmong women in obtaining a Pap test. Out of 402 women who participated in a baseline survey, the Patient Navigation Program was able to enroll 109 participants who had not had a Pap test in the past 3 years and had never had a Pap test. Through utilization of outreach, an awareness campaign and patient navigation support, at least 38 percent of 109 participants obtained a Pap test. Overall, 21 workshops and 43 outreach activities were conducted by the Hmong Women’s Heritage Association, leading to 63 percent of those enrolled in the Patient Navigation Program who could be contacted to obtain a Pap test.

  1. Species identification of processed animal proteins (PAPs) in animal feed containing feed materials from animal origin.

    Science.gov (United States)

    Axmann, Sonja; Adler, Andreas; Brandstettner, Agnes Josephine; Spadinger, Gabriela; Weiss, Roland; Strnad, Irmengard

    2015-01-01

    Since June 2013 the total feed ban of processed animal proteins (PAPs) was partially lifted. Now it is possible to mix fish feed with PAPs from non-ruminants (pig and poultry). To guarantee that fish feed, which contains non-ruminant PAPs, is free of ruminant PAPs, it has to be analysed with a ruminant PCR assay to comply with the total ban of feeding PAPs from ruminants. However, PCR analysis cannot distinguish between ruminant DNA, which originates from proteins such as muscle and bones, and ruminant DNA, which comes from feed materials of animal origin such as milk products or fat. Thus, there is the risk of obtaining positive ruminant PCR signals based on these materials. The paper describes the development of the combination of two analysis methods, micro-dissection and PCR, to eliminate the problem of 'false-positive' PCR signals. With micro-dissection, single particles can be isolated and subsequently analysed with PCR.

  2. Bone scintigraphy, plasma ALP, TAP and PAP in patients with prostatic cancer

    International Nuclear Information System (INIS)

    Imamura, Akihiko; Hoshi, Hiroaki; Jinnouchi, Seishi; Samejima, Masahiko; Watanabe, Katsushi

    1988-01-01

    This study assessed the ability of bone scintigraphy, alkaline phosphatase (ALP), total acid phosphatase (TAP), and prostatic acid phosphatase (PAP) to diagnose bone metastasis in a series of 62 patients with histologically proven prostatic cancer. Abnormal uptake was seen on the bone scan in 49 patients (79 %). A final diagnosis of bone metastasis was made in 40 patients (65 %). The sensitivity and specificity were 100 % and 59 %, respectively, for bone scintigraphy; 50 % and 96 % for ALP; 65 % and 82 % for TAP; and 73 % and 77 % for PAP. For 40 patients with bone metastasis, all of the ALP, TAP, and PAP were positive in 17 patients (43 %) and negative in 8 patients (20 %). Higher levels of ALP, TAP, and PAP tended to be associated with more extensive bone metastasis. Although serological examination showed lower sensitivity than bone scintigraphy in the diagnosis of bone metastasis, PAP may be most frequently used as a screening procedure of bone metastasis. (Namekawa, K.)

  3. First experiences with commercial RIA kits for prostatic acid phosphatase (PAP)

    Energy Technology Data Exchange (ETDEWEB)

    Boettger, I; Langhammer, H; Pabst, H W; Sintermann, R

    1980-06-01

    Five commercial PAP RIA kits were intercompared by common RIA quality control criteria. All RIAs performed basically well although some differences existed in respect to concentration range, specific and non-specific binding, 50%-intercept, sensitivity and measurements of serum PAP in male and female controls. The latter finding may have been due to differences in antigen purity, antiserum specificity and composition of the assay medium employed. Good correlation was found between PAP determination by RIA and by enzyme assay. First measurements of PAP in patients treated for prostatic carcinoma being performed for orientation purposes are demonstrated. The PAP RIA has been introduced into our routine diagnostic and follow-up of prostatic carcinoma.

  4. Pap smears for men: a vision of the future?

    LENUS (Irish Health Repository)

    Oon, S F

    2012-02-01

    BACKGROUND: Anal intraepithelial neoplasia (AIN) rarely receives as much publicity as its neighbouring orifice, the cervix. As in the cervix, intraepithelial neoplasias are precursors to cancer in the anal canal. AIN and cervical interstitial neoplasia (CIN) undergo dysplasia as a consequence of human papillomavirus (HPV) infection. Since the advent of screening with the Pap smear in CIN, cervical cancer has plummeted to a fifth of its initial incidence. Anal cancer, however, has been rising, with a predilection for human immunodeficiency virus-infected men. HPV causes a squamous epithelial dysplasia and converts healthy tissue into AINs of increasing severity until anal cancer manifests. CLINICAL CASE: This article describes a clinical case of anogenital HPV infection refractory to medical and surgical therapy. It also describes an effective surgical excision technique associated with a good cosmetic outcome. CONCLUSIONS: The paper concludes by briefly discussing the implications of a national screening programme against AIN in the future.

  5. Molecular dynamics studies of the P pilus rod subunit PapA.

    Science.gov (United States)

    Vitagliano, Luigi; Ruggiero, Alessia; Pedone, Carlo; Berisio, Rita

    2009-03-01

    Adhesion of uropathogenic Escherichia coli to host tissues is mediated by pili, which extend from the outer cell membrane of the bacterium. Here we report molecular dynamics (MD) characterizations of the major constituent of P pili from the uropathogenic E. coli, PapA, in unliganded state and in complex with the G1 strand of the chaperone PapD. To mimic the PapA response to the gradual dissociation of the PapD G1 strand and to evaluate the role of PapA chaperone recognition sites, we also carried out MD simulations of complexes of PapA with fragments of PapD G1 strand, that leave either the P4 or both P3 and P4 sites unoccupied. Data on the unbound form of PapA indicate that, upon release of the chaperone, PapA evolves toward compact states that are likely not prone to subunit-subunit association. In line with recent experimental reports, this finding implies that chaperone release and subunit-subunit association must be concerted. Our data also indicated that the gradual unbinding of the chaperone from the PapA groove has increasingly strong structural consequences. Indeed, the release of the chaperone from the site P4, which is closest to the initiation site (P5), does not have dramatic effects on the domain structure, whereas its release from both the P4 and the adjacent P3 sites induces a quick structural transition toward a collapsed state, where the subunit groove is obstructed.

  6. Paediatric ED BiPAP continuous quality improvement programme with patient analysis: 2005-2013.

    Science.gov (United States)

    Abramo, Thomas; Williams, Abby; Mushtaq, Samaiya; Meredith, Mark; Sepaule, Rawle; Crossman, Kristen; Burney Jones, Cheryl; Godbold, Suzanne; Hu, Zhuopei; Nick, Todd

    2017-01-16

    In paediatric moderate-to-severe asthmatics, there is significant bronchospasm, airway obstruction, air trapping causing severe hyperinflation with more positive intraplural pressure preventing passive air movement. These effects cause an increased respiratory rate (RR), less airflow and shortened inspiratory breath time. In certain asthmatics, aerosols are ineffective due to their inadequate ventilation. Bilevel positive airway pressure (BiPAP) in acute paediatric asthmatics can be an effective treatment. BiPAP works by unloading fatigued inspiratory muscles, a direct bronchodilation effect, offsetting intrinsic PEEP and recruiting collapsed alveoli that reduces the patient's work of breathing and achieves their total lung capacity quicker. Unfortunately, paediatric emergency department (PED) BiPAP is underused and quality analysis is non-existent. A PED BiPAP Continuous Quality Improvement Program (CQIP) from 2005 to 2013 was evaluated using descriptive analytics for the primary outcomes of usage, safety, BiPAP settings, therapeutics and patient disposition. PED BiPAP CQIP descriptive analytics. Academic PED. 1157 patients. A PED BiPAP CQIP from 2005 to 2013 for the usage, safety, BiPAP settings, therapeutic response parameters and patient disposition was evaluated using descriptive analytics. Safety, usage, compliance, therapeutic response parameters, BiPAP settings and patient disposition. 1157 patients had excellent compliance without complications. Only 6 (0.5%) BiPAP patients were intubated. BiPAP median settings: IPAP 18 (16,20) cm H 2 O range 12-28; EPAP 8 cmH 2 O (8,8) range 6-10; inspiratory-to-expiratory time (I:E) ratio 1.75 (1.5,1.75). Pediatric Asthma Severity score and RR decreased (pimproved therapeutics times, very low intubations and decreased PICU admissions. CQIP analysis demonstrated that using a higher IPAP, low EPAP with longer I:E optimises the patient's BiPAP settings and showed a significant improvement in PAS, RR and tidal volume. BiPAP

  7. Nuclear Phosphatidylinositol-Phosphate Type I Kinase α-Coupled Star-PAP Polyadenylation Regulates Cell Invasion.

    Science.gov (United States)

    A P, Sudheesh; Laishram, Rakesh S

    2018-03-01

    Star-PAP, a nuclear phosphatidylinositol (PI) signal-regulated poly(A) polymerase (PAP), couples with type I PI phosphate kinase α (PIPKIα) and controls gene expression. We show that Star-PAP and PIPKIα together regulate 3'-end processing and expression of pre-mRNAs encoding key anti-invasive factors ( KISS1R , CDH1 , NME1 , CDH13 , FEZ1 , and WIF1 ) in breast cancer. Consistently, the endogenous Star-PAP level is negatively correlated with the cellular invasiveness of breast cancer cells. While silencing Star-PAP or PIPKIα increases cellular invasiveness in low-invasiveness MCF7 cells, Star-PAP overexpression decreases invasiveness in highly invasive MDA-MB-231 cells in a cellular Star-PAP level-dependent manner. However, expression of the PIPKIα-noninteracting Star-PAP mutant or the phosphodeficient Star-PAP (S6A mutant) has no effect on cellular invasiveness. These results strongly indicate that PIPKIα interaction and Star-PAP S6 phosphorylation are required for Star-PAP-mediated regulation of cancer cell invasion and give specificity to target anti-invasive gene expression. Our study establishes Star-PAP-PIPKIα-mediated 3'-end processing as a key anti-invasive mechanism in breast cancer. Copyright © 2018 A.P. and Laishram.

  8. Interplay of the modified nucleotide phosphoadenosine 5'-phosphosulfate (PAPS) with global regulatory proteins in Escherichia coli: modulation of cyclic AMP (cAMP)-dependent gene expression and interaction with the HupA regulatory protein.

    Science.gov (United States)

    Longo, Francesca; Motta, Sara; Mauri, Pierluigi; Landini, Paolo; Rossi, Elio

    2016-11-25

    In the bacterium Escherichia coli, some intermediates of the sulfate assimilation and cysteine biosynthesis pathway can act as signal molecules and modulate gene expression. In addition to sensing and utilization of sulphur sources, these signaling mechanisms also impact more global cell processes, such as resistance to antimicrobial agents and biofilm formation. In a recent work, we have shown that inactivation of the cysH gene, encoding phosphoadenosine-phosphosulfate (PAPS) reductase, and the consequent increase in intracellular PAPS concentration, strongly affect production of several cell surface-associated structures, enhancing surface adhesion and cell aggregation. In order to identify the molecular mechanism relaying intracellular PAPS concentration to regulation of cell surface-associated structures, we looked for mutations able to suppress the effects of cysH inactivation. We found that mutations in the adenylate cyclase-encoding cyaA gene abolished the effects of PAPS accumulation; consistent with this result, cyclic AMP (cAMP)-dependent gene expression appears to be increased in the cysH mutant. Experiments aimed at the direct identification of proteins interacting with either CysC or CysH, i.e. the PAPS-related proteins APS kinase and PAPS reductase, allowed us to identify several regulators, namely, CspC, CspE, HNS and HupA. Protein-protein interaction between HupA and CysH was confirmed by a bacterial two hybrid system, and inactivation of the hupA gene enhanced the effects of the cysH mutation in terms of production of cell surface-associated factors. Our results indicate that PAPS can modulate different regulatory systems, providing evidence that this molecule acts as a global signal molecule in E. coli. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  9. Use of and attitudes and knowledge about pap smears among women in Kuwait.

    Science.gov (United States)

    El-Hammasi, Khadija; Samir, Ola; Kettaneh, Soania; Al-Fadli, Athari; Thalib, Lukman

    2009-11-01

    To estimate the lifetime prevalence of Pap smear among women in Kuwait and to assess their knowledge about and attitude toward Pap smears. This was a descriptive cross-sectional study using a multistage cluster sampling method. We interviewed 299 women attending polyclinics in Kuwait using a self-administered questionnaire. Factors related to history of having a Pap smear, knowledge level, and willingness to participate in a screening program were evaluated. The lifetime prevalence of Pap smear was found to be 37% (95% CI 33-43). Forty-four percent of women in our study had a Pap smear only once in their lives. History of having at least one Pap smear was significantly related to such factors as age, total family income, marital status, history of cervical infection, and knowledge. The level of knowledge about cervical cancer varied among the participants. Forty-six percent of women were uncertain about the symptoms of cervical cancer. About half the women recognized cervical infection, smoking, and having multiple sexual partners as risk factors for cervical cancer; however, only 10% recognized early sexual intercourse as a risk factor. Willingness to participate in a future screening program varied significantly according to educational level, employment status, and total family income. Although cervical cancer incidence and mortality are relatively low in Kuwait, they may be underreported in the absence of a screening program. Moreover, lifetime prevalence of having a Pap smear was found to be considerably lower in Kuwait compared with developed countries.

  10. Les sources littéraires des citations peintes sur les phylactères des saints de la rangée inférieure de la façade et de l’exonarthex de l’église de la Résurrection de Dieu du monastère de Suceviţa

    Directory of Open Access Journals (Sweden)

    Constantin I. Ciobanu

    2015-12-01

    Full Text Available Cette étude vise à découvrir les sources littéraires des citations peintes sur les phylactères des saints de la rangée inférieure de la façade et de l’exonarthex de l’église de la Résurrection de Dieu du monastère de Suceviţa. Elle est une suite de l’article sur les sentences des pères du désert, des confesseurs, des anachorètes et des stylites peints sur la façade méridionale de l’église de l’Annonciation de la Vierge de Moldoviţa. Son objectif est de donner un aperçu précis sur la variété des sources littéraires qui ont été choisies par les auteurs du programme iconographique du dernier ensemble de peintures murales extérieures moldaves peintes au XVIe siècle. L’auteur de l’étude montre que ces citations de Suceviţa sont en grande partie tirées de la Collection alphabétique des Sentences des Pères du Désert. Cette Collection alphabétique a le rôle joué au monastère de Moldoviţa par la sélection des sources grecques primaires de la traduction russe du XIXe siècle faite par Théophane le Reclus et appelée par celui-ci Paterikon palestinien. La paternité des ces citations est plus ou moins arbitraire à Suceviţa : nous observons une attribution correcte seulement dans les cas des images des saints Antoine, Nil, Arsène, Étienne le Nouveau, Barlaam et Isaïe. De ce point de vue, la situation est semblable à celle observée aux monastères de Humor et de Moldoviţa. Dans le programme iconographique de Suceviţa il y a plusieurs répétitions des mêmes citations : elles sont attribuées à divers ou aux mêmes saints. C’est le cas des citations de Saint Chariton et de Saint Daniel le Stylite, de Saint Cyriaque l’Anachorète et de Saint Patapios, de Saint Athanase l’Athonite et de Saint Jean le Calybite, de Saint Nil et de Saint Gérasime, de Saint Jean Damascène (qui est peint deux fois : sur la façade sud et dans l’exonarthex, de Saint Théodore le Confesseur et de Saint Th

  11. A qualitative study exploring factors associated with Pap test use among North Korean refugees.

    Science.gov (United States)

    Kim, Kyounghae; Kim, Soohyun; Chung, Yoonkyung

    2017-10-01

    Lack of medical care in North Korea and vulnerability to human trafficking during their migration increase risks of cervical cancer among North Korean refugees. To better understand factors influencing Pap test use, we conducted a qualitative study of eight North Korean refugees in South Korea. Individual barriers were limited knowledge, lack of perceived need for preventive services, and concerns about costs. Environmental facilitators included having female providers, receiving family support, and free screenings. Refugees' health outlook, including viewing cancers as fatal diseases, hindered seeking Pap tests. Multi-faceted approaches to address individual and environmental factors in promoting Pap tests are warranted.

  12. Influencing Factors of Intention to Receive Pap Tests in Vietnamese Women who Immigrated to Taiwan for Marriage.

    Science.gov (United States)

    Lee, Fang-Hsin; Wang, Hsiu-Hung; Yang, Yung-Mei; Huang, Joh-Jong; Tsai, Hsiu-Min

    2016-09-01

    This study aimed to explore the factors associated with the intention to receive a Pap test among married immigrant women of Vietnamese origin living in Taiwan. This was a cross-sectional community-based study. We enrolled 281 women aged 30 years and over in the study, from July 2013 to January 2014. The participants' characteristics, cervical cancer knowledge, Pap test knowledge, attitudes toward cervical cancer, barriers to receiving a Pap test, fatalism, and intention to receive a Pap test, were measured using self-report questionnaires. Hierarchical multiple regression analyses were performed to examine the variables associated with participants' intentions to receive a Pap test. Vietnamese women with low scores on the measures of cervical cancer knowledge and perceived barriers to receiving a Pap test were more willing to receive the test, as were those with high scores on the measures of Pap test knowledge and fatalism. Women who received a Pap test in the previous year were more willing to receive a Pap test within the next 3 years. Preventive healthcare for immigrant women should be a focus of nurses. The development of culturally appropriate health education and strategies should enhance their knowledge of Pap tests and reduce perceived barriers to Pap test participation. This study's results can be a reference for nurses who work with immigrant women. Copyright © 2016. Published by Elsevier B.V.

  13. Resíduos do beneficiamento do camarão cultivado: obtenção de pigmentos carotenóides Waste from the processing of farmed shrimp: a source of carotenoid pigments

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    Masayoshi Ogawa

    2007-06-01

    Full Text Available A extração de pigmentos carotenóides constitui uma possível alternativa, de grande agregação de valor, para o aproveitamento da cabeça do camarão Litopenaeus vannamei. O objetivo do presente trabalho foi a identificação, a extração e a quantificação dos principais pigmentos desta matéria-prima, coletados a partir de uma planta de beneficiamento de camarão no Ceará - Brasil. Após cocção dos resíduos a 100 °C, na proporção 1:2 cabeça de camarão e água durante 15 minutos, obteve-se uma pasta de pigmentos brutos extraindo-se os carotenóides com acetona resfriada e, posteriormente, com hexano, obtendo a fase pigmento-hexano. Obteve-se também a fase DMSO, após o material ser particionado com dimetilsulfóxido, e uma fração acidificada. Estas frações sofreram evaporação e secagem, sendo os carotenóides identificados em coluna aberta, utilizando-se o parâmetro de eluição das frações, o espectro de absorção visível e o valor de Rf na camada delgada de sílica gel. Os espectros de absorção de cada fração foram obtidos a 350 a 550 nm e quantificados por cromatografia de camada delgada. Para o cálculo de carotenóides totais (37,62 µg.g-1 da pasta de pigmentos, utilizou-se o somatório das frações hexano, DMSO e acidificada, e coeficientes de extinção 2592, 2100 e 1690 referentes ao beta-caroteno, astaxantina e astaceno, respectivamente. A astaxantina foi o pigmento mais abundante (45,5%, seguido do beta-caroteno-5,6-epóxido (33,5% e do astaceno (21,0%.The extraction of carotenoid pigments from shrimp heads left over from the processing of Litopenaeus vannamei has been shown to constitute an economically feasible alternative for aggregating value to shrimp processing waste. The objective of the present study was to extract, identify and quantify the main pigments found in shrimp heads collected at a shrimp processing plant in Ceará (Brazil. Samples were cooked for 15 minutes at 100 °C in water at a

  14. [Pap smear for mass screening: Results of an African experiment].

    Science.gov (United States)

    Somé, O-R; Zongo, N; Ka, S; Wardini, R; Dem, A

    2016-06-01

    To assess the impact of smear test in the fight against cervix uteri cancer in Senegal. This was a descriptive cross-sectional study of 1836 Pap smears performed in patients over 15 years during several screening campaigns in Senegal conducted between June 2010 and June 2012. We analyzed epidemiological data, pathological smears, and the proposed management. In 69% of cases, the women were less than 45 years old. They were mostly multiparous and did not use contraceptive methods before. The smears were interpreted in 91.4% (n=1661) and were pathological in 5.2% of cases. They revealed mainly atypical squamous cells of undetermined significance, squamous intraepithelial low-grade lesions, and squamous intraepithelial high-grade lesions, respectively in 2.5% (n=46), 1.7% (n=30) and 1% (n=19) of cases. Multiparity, early marriages were the main risk factors. Patients with pathological smars had colposcopy with cryotherapy (23 cases), and colposcopy and biopsy (13 cases). A hysterectomy was performed in 4 cases. The pathological smear rate found in this study confirms the interest to continue cervical cancer screening with this practice. Strengthening of its geographical and financial access through a national prevention program will effectively help to lower cases of cervical cancer. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  15. The limits of pap smear in diagnosing preinvasive cervical neoplasias

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    Dorina Neacsu

    2011-12-01

    Full Text Available The cervical-vaginal cytology can be interpreted after many classifications, starting from Babeú- Papanicolaou and ending with the Bethesda system, but no matter what the interpretation manner is it is really important to have a good quality of the smears and an experienced cytologist. If we refer to the total number of cases from the lot presented - 16732 cases, the results are satisfactory; 83% smears having normal limits, 10.14% MCB, 2.71% L-SIL, 0.82% H-SIL, 2.77% ASCUS, 0.10% AGC. In Iaúi there are significantly more patients with benign cell changes and L- SIL, while in Buzău there are significantly more patients with a normal smear, but there is also a higher frequency of theatypical squamous cells with an undetermined significance. Classically specialists say that 50-75% of the false negative results are due to the errors made when harvesting the sample. In conclusion we estimate that considering the present conditions in our country where the lack of interest and financial possibilities do not allow an action of detecting the lesions of the cervix organized nationwide, we can still make a selection of the cases with a high risk by making a free Pap smear for all the patients that come to a specialized service, either state or private, provided they respect the protocol of harvesting the cervical secretions, of preparing and reading/interpreting the smears.

  16. RES-E Support Policies In The Baltic States: Development Aspect (Part I

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    Bobinaite V.

    2015-02-01

    Full Text Available Despite quite similar conditions (natural resources for electricity production from renewable energy sources (RES-E in three Baltic States (Estonia, Latvia and Lithuania, significant differences exist in these countries as to the RES-E production volume. In Latvia this volume is the highest, while in Estonia and Lithuania it is half as high. One of the factors that determine the RES-E production volumes is support policies, which in the Baltic States are different. The main objective of this work was to analyze and compare these support policies. The results have shown that for rapid RES-E development the most effective policy is to be market-oriented (as in Estonia, whereas for more stable development such policy should be producer-oriented (as in Lithuania.

  17. PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor

    International Nuclear Information System (INIS)

    Maita, Hiroshi; Kitaura, Hirotake; Keen, T. Jeffrey; Inglehearn, Chris F.; Ariga, Hiroyoshi; Iguchi-Ariga, Sanae M.M.

    2004-01-01

    PAP-1 is an in vitro phosphorylation target of the Pim-1 oncogene. Although PAP-1 binds to Pim-1, it is not a substrate for phosphorylation by Pim-1 in vivo. PAP-1 has recently been implicated as the defective gene in RP9, one type of autosomal dominant retinitis pigmentosa (adRP). However, RP9 is a rare disease and only two missense mutations have been described, so the report of a link between PAP-1 and RP9 was tentative. The precise cellular role of PAP-1 was also unknown at that time. We now report that PAP-1 localizes in nuclear speckles containing the splicing factor SC35 and interacts directly with another splicing factor, U2AF35. Furthermore, we used in vitro and in vivo splicing assays to show that PAP-1 has an activity, which alters the pattern of pre-mRNA splicing and that this activity is dependent on the phosphorylation state of PAP-1. We used the same splicing assay to examine the activities of two mutant forms of PAP-1 found in RP9 patients. The results showed that while one of the mutations, H137L, had no effect on splicing activity compared with that of wild-type PAP-1, the other, D170G, resulted in both a defect in splicing activity and a decreased proportion of phosphorylated PAP-1. The D170G mutation may therefore cause RP by altering splicing of retinal genes through a decrease in PAP-1 phosphorylation. These results demonstrate that PAP-1 has a role in pre-mRNA splicing and, given that three other splicing factors have been implicated in adRP, this finding provides compelling further evidence that PAP-1 is indeed the RP9 gene

  18. Negative HPV screening test predicts low cervical cancer risk better than negative Pap test

    Science.gov (United States)

    Based on a study that included more than 1 million women, investigators at NCI have determined that a negative test for HPV infection compared to a negative Pap test provides greater safety, or assurance, against future risk of cervical cancer.

  19. Decision making about Pap test use among Korean immigrant women: A qualitative study.

    Science.gov (United States)

    Kim, Kyounghae; Kim, Soohyun; Gallo, Joseph J; Nolan, Marie T; Han, Hae-Ra

    2017-08-01

    Understanding how individuals make decisions about Pap tests concerning their personal values helps health-care providers offer tailored approaches to guide patients' decision making. Yet research has largely ignored decision making about Pap tests among immigrant women who experience increased risk of cervical cancer. To explore decision making about Pap tests among Korean immigrant women. We conducted a qualitative descriptive study using 32 semi-structured, in-depth interviews with Korean immigrant women residing in a north-eastern metropolitan area. Data were audio-recorded, transcribed verbatim and analysed using inductive coding. Although most women with positive decisions made their own decisions, some women deferred to their providers, and others made decisions in collaboration with their providers and significant others. While women making positive decisions tended to consider both barriers to and facilitators of having Pap tests, women making negative decisions predominantly discussed the barriers to having Pap tests, such as modesty and differences between the South Korean and US health-care systems. The women's reflections on their decisions differed regarding their Pap test decisions. Women's desired roles in the decision-making process and reflection on their decision outcome appeared to vary, although most participants with positive decisions made their own decisions and were satisfied with their decisions. Future research should conduct longitudinal, quantitative studies to test our findings regarding decision-making processes and outcomes about Pap tests. The findings should be incorporated into cervical cancer screening practices to fulfil the unmet needs of immigrant women in patient-provider communication and to facilitate women's decision making about Pap tests. © 2016 The Authors. Health Expectations published by John Wiley & Sons Ltd.

  20. Trends in Pap Testing Over Time for Women With and Without Chronic Disability.

    Science.gov (United States)

    Iezzoni, Lisa I; Kurtz, Stephen G; Rao, Sowmya R

    2016-02-01

    Data from 20 years ago--shortly after passage of the Americans with Disabilities Act--showed that women with significant mobility disability had 40% lower Pap test rates than other women. To examine whether disability disparities in Pap test rates have diminished over time, this study analyzed National Health Interview Survey responses from selected years between 1998 and 2010 from women aged 21-65 years without histories of cervical cancer or hysterectomy. Seven chronic disability types were identified using self-reported functional impairments or participation limitations. Self-reported Pap testing within the previous 3 years was studied. Bivariable analyses and multivariable logistic regression analyses controlling for sociodemographic variables were conducted in 2014. Rates of all chronic disability types increased over time. Pap test rates remained relatively constant over time for all women, holding around 84%-87%. Bivariable analyses found statistically significantly lower rates of Pap testing for women with disability compared with nondisabled women. Multivariable analyses failed to find consistent evidence of lower Pap test rates among women across disability types compared with nondisabled women. In 2010, the AOR for reporting Pap testing for women noting the most severe movement difficulty compared with nondisabled women was 0.35 (95% CI=0.15, 0.79). However, the AOR for this disability type varied over time. Little has changed over time in Pap test rates for all women. Women with certain disabilities continue to experience disparities compared with nondisabled women in receipt of this important screening test. Copyright © 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  1. Perceptions and concerns of women undergoing Pap smear examination in a tertiary care hospital of India.

    Science.gov (United States)

    Tiwari, A; Kishore, J; Tiwari, A

    2011-01-01

    Cervical cancer is one of the major causes of deaths due to cancer among women in India. Pap smear is one of the best methods to detect early changes in cervix. However, there is lack of data on awareness level of women about Pap smear and various risk factors for cervical cancer. To study the awareness about various risk factors for cervical cancer, health-seeking behavior and hygienic practices among women and to assess the distress experienced by these women before the Pap smear examination. This cross-sectional study was carried out on women coming for a Pap smear examination in a tertiary teaching hospital in New Delhi. A pretested interview schedule was used to get information after obtaining their informed consent. Fifty-seven percent stated that they did not consult a doctor when they noticed the symptoms the first time. Sixty-one percent did not know what a cervical cancer is and a same percentage of women did not know what a Pap smear examination was. Older age group, Muslim and literate women had higher number of abnormal Pap smear results. Women who reported being stressed in their lives had higher number of abnormal smears as compared to women who claimed to lead a stress free life. Poor hygienic practices among these women from urban areas were also associated with abnormal Pap smear results. The study concluded that factors such as poor awareness, shyness, poor hygiene, and old age could be responsible for abnormal Pap smears and this needs special attention in cancer prevention activities of the government.

  2. PENYULUHAN METODE PAP SMEAR TERHADAP TINGKAT PENGETAHUAN DAN SIKAP WANITA TUNA SUSILA DALAM PENDETEKSIAN KANKER SERVIKS

    Directory of Open Access Journals (Sweden)

    Ismi Wulandari AS

    2015-03-01

    Full Text Available Abstract: The Effectiveness Of Pap smear Test’s Counseling Regarding To The Level Of Knowledge And Behaviour In Prostitution Worker For Detection Of Cervical Cancer In Bintang Mas Kubu Raya 2014. The aim of this study is to evaluate the effectivity of counseling toward knowledge and behavior. in prostitution worker about pap smear and cervical cancer. This research was quasi-experimental with one group pretest-postest design. There are 38 respondents. McNemar test showed there are significant. improvement of knowledge (p<0.05, and significance behavior change (p<0.05 in all respondents before and after counseling. Keyword : knowledge, behaviour, cervical cancer, pap smear Abstrak : Penyuluhan Metode Pap smear Terhadap Tingkat Pengetahuan Dan Sikap Wanita Tuna Susila Dalam Pendeteksian Kanker Serviks. Tujuan penelitian ini yaitu untuk melihat efektivitas terhadap pengetahuan dan sikap melalui penyuluhan mengenai pap smear kepada para wanita tuna susila. Rancangan penelitian yang digunakan dalam penelitian ini adalah quasi eksperimental dengan rancangan one group pretest-postest design. Besar sampel berjumlah 38 orang. Hasil menunjukkan uji McNemar menunjukkan terdapat signifikansi yang bermakna untuk pengetahuan (p < 0,05 dan signifikansi untuk perubahan sikap (p<0.05 pada responden sebelum dan setelah penyuluhan. Kata kunci : pengetahuan, sikap, kanker serviks, pap smear

  3. Nutritional Composition of Five Varieties of Pap Commonly Consumed in Maroua (Far-North, Cameroon

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    Ponka Roger

    2015-09-01

    Full Text Available The aim of this study was to determine the nutritional composition of five varieties of pap (cereal product commonly consumed in Maroua, city of the Far-North Region of Cameroon. The proximate composition (moisture, ash, protein, lipid, and crude fibre was determined by standard AOAC methods. Minerals (calcium, magnesium, sodium, potassium, iron, zinc, copper and manganese were determined by atomic absorption spectrophotometry and phosphorus was determined colorimetrically. Amino acid composition was determined by ion-exchange chromatography. All the pap varieties had a very high carbohydrate content (79.47-85.29 g/100 g dry matter. Appreciable levels of phosphorus and potassium were recorded in all the pap varieties (137.5-231.0 mg/100 g dry matter and 198.20-322.22 mg/100 g dry matter, respectively. Consumption of each pap (100 g by children 1-2 year old would meet 9.86-17.46% and 0.08-19.51% of their daily recommended intake respectively for protein and minerals. Leucine and glutamic acid were the most abundant essential amino acids and non-essential amino acids respectively in the pap. Essential amino acids in most of the pap samples met the recommended children requirement of the FAO/WHO/UNU for 1-2 year old children except methionine+cysteine and lysine.

  4. Comparison of visual inspection of cervix and pap smear for cervical cancer screening

    International Nuclear Information System (INIS)

    Tayyeb, R.; Khawaja, N.P.; Malik, N.

    2003-01-01

    Objective: To evaluate the performance of visual inspection of cervix (VIA) after application of 3% acetic acid in cervical cancer screening in comparison with PAP smear. Results: Out of 540 subjects, 356 were negative with both screening techniques. One hundred and fifty-six subjects were positive with VIA (28.9%) while PAP smear was positive in seventy-eight subjects (14.4%). The sensitivity of VIA was 93.9% and of PAP smear was 46.9%. Corresponding specificities were 30.4% and 69.5%. There was no significant difference between the positive predictive value (PPV) of both test (p<0.05). The accuracy of VIA was 77.5% compared to 52.8% of PAP smear. The difference was highly significant (p < 0.01). Conclusion: These results indicate that VIA is more sensitive and has a higher accuracy as compared to PAP smear. It could, therefore, be valuable in detection of precancerous lesions of cervix. Low cost, easy applicability and immediate results make VIA a useful screening test in developing countries like Pakistan as compared to PAP smear. (author)

  5. Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis.

    Science.gov (United States)

    Maier, Alexander; Schrader, Andrea; Kokkelink, Leonie; Falke, Christian; Welter, Bastian; Iniesto, Elisa; Rubio, Vicente; Uhrig, Joachim F; Hülskamp, Martin; Hoecker, Ute

    2013-05-01

    Anthocyanins are natural pigments that accumulate only in light-grown and not in dark-grown Arabidopsis plants. Repression of anthocyanin accumulation in darkness requires the CONSTITUTIVELY PHOTOMORPHOGENIC1/SUPPRESSOR OF PHYA-105 (COP1/SPA) ubiquitin ligase, as cop1 and spa mutants produce anthocyanins also in the dark. Here, we show that COP1 and SPA proteins interact with the myeloblastosis (MYB) transcription factors PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP)1 and PAP2, two members of a small protein family that is required for anthocyanin accumulation and for the expression of structural genes in the anthocyanin biosynthesis pathway. The increased anthocyanin levels in cop1 mutants requires the PAP1 gene family, indicating that COP1 functions upstream of the PAP1 gene family. PAP1 and PAP2 proteins are degraded in the dark and this degradation is dependent on the proteasome and on COP1. Hence, the light requirement for anthocyanin biosynthesis results, at least in part, from the light-mediated stabilization of PAP1 and PAP2. Consistent with this conclusion, moderate overexpression of PAP1 leads to an increase in anthocyanin levels only in the light and not in darkness. Here we show that SPA genes are also required for reducing PAP1 and PAP2 transcript levels in dark-grown seedlings. Taken together, these results indicate that the COP1/SPA complex affects PAP1 and PAP2 both transcriptionally and post-translationally. Thus, our findings have identified mechanisms via which the COP1/SPA complex controls anthocyanin levels in Arabidopsis that may be useful for applications in biotechnology directed towards increasing anthocyanin content in plants. © 2013 The Authors The Plant Journal © 2013 John Wiley & Sons Ltd.

  6. Renewables portfolio, individual preferences and social values towards RES technologies

    International Nuclear Information System (INIS)

    Kontogianni, Areti; Tourkolias, Christos; Skourtos, Michalis

    2013-01-01

    The massive deployment of renewable energy sources represents a high priority for Greece in order to comply with the Directive 2009/28/EC on the promotion of the use of energy from renewable sources by 2020. In this perspective, Aegean islands especially Lesvos, are endowed with a considerable potential of a portfolio of renewables, a fact that the entrepreneurial interest has already been targeted. However, regulatory attempts for a massive penetration of renewables do not take seriously into account preferences and risk perceptions of local communities where the proposed projects are to be installed. The aim of this study is to investigate individual preferences and social values towards specific technologies of renewables in Lesvos island. We apply an open-ended contingent valuation survey in order to analyze factors shaping public attitudes towards a portfolio of renewable technologies and estimate the economic welfare (Willingness To Pay) of the preferred technologies. We argue that such information is relevant for energy policy design and the establishment of effective measures for the promotion of renewable energy sources. - Highlights: ► We investigate individual preferences and attitudes towards a portfolio of RES technologies. ► We elicit public acceptance for investing in specific RES technologies. ► We analyze factors shaping public preferences of the preferred technologies. ► We estimate the economic welfare of the preferred technologies

  7. Agroecologia: Potencializando os papéis das mulheres rurais

    Directory of Open Access Journals (Sweden)

    Fabiana da Silva Andersson

    2017-04-01

    Full Text Available O artigo analisa se e como a agroecologia potencializa os papéis das mulheres rurais, em sua maioria agricultoras, dos municípios de Arroio do Padre e São Lourenço do Sul (RS. Através da realização de entrevistas em profundidade e da observação participante, o artigo analisa as percepções dessas mulheres a respeito das realidades por elas vivenciadas tanto no âmbito produtivo (lavoura como reprodutivo (doméstico. É importante destacar que, em Arroio do Padre, há um processo incipiente de “agroecologização”, ou seja, as unidades familiares encontram-se nos níveis iniciais da transição agroecológica. Já em São Lourenço do Sul, observou-se que essas mulheres atuam na agroecologia há mais de 40 anos. Estas distintas trajetórias conferem percepções de mundo diferenciadas entre os dois contextos sociais. Enquanto para as interlocutoras de Arroio do Padre a agroecologia pouco interfere em suas escolhas dentro e fora de casa, já para as entrevistadas de São Lourenço do Sul é essencial no repensar das relações estabelecidas no lar e no seu entorno, especialmente nos assuntos que tangem aos mercados e a sua valorização enquanto “agricultora”.

  8. Region-based multifocus image fusion for the precise acquisition of Pap smear images.

    Science.gov (United States)

    Tello-Mijares, Santiago; Bescós, Jesús

    2018-05-01

    A multifocus image fusion method to obtain a single focused image from a sequence of microscopic high-magnification Papanicolau source (Pap smear) images is presented. These images, captured each in a different position of the microscope lens, frequently show partially focused cells or parts of cells, which makes them unpractical for the direct application of image analysis techniques. The proposed method obtains a focused image with a high preservation of original pixels information while achieving a negligible visibility of the fusion artifacts. The method starts by identifying the best-focused image of the sequence; then, it performs a mean-shift segmentation over this image; the focus level of the segmented regions is evaluated in all the images of the sequence, and best-focused regions are merged in a single combined image; finally, this image is processed with an adaptive artifact removal process. The combination of a region-oriented approach, instead of block-based approaches, and a minimum modification of the value of focused pixels in the original images achieve a highly contrasted image with no visible artifacts, which makes this method especially convenient for the medical imaging domain. The proposed method is compared with several state-of-the-art alternatives over a representative dataset. The experimental results show that our proposal obtains the best and more stable quality indicators. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

  9. Time-dependent effect of p-Aminophenol (PAP) toxicity in renal slices and development of oxidative stress

    International Nuclear Information System (INIS)

    Harmon, R. Christopher; Terneus, Marcus V.; Kiningham, Kinsley K.; Valentovic, Monica

    2005-01-01

    p-Aminophenol (PAP), a metabolite of acetaminophen, is nephrotoxic. This study investigated PAP-mediated changes as a function of time that occur prior to loss of membrane integrity. Experiments further evaluated the development of oxidative stress by PAP. Renal slices from male Fischer 344 (F344) rats (N = 4-6) were exposed to 0.1, 0.25, and 0.5 mM PAP for 15-120 min under oxygen and constant shaking at 37 o C. Pyruvate-stimulated gluconeogenesis, adenine nucleotide levels, and total glutathione (GSH) levels were diminished in a concentration- and time-dependent manner prior to detection of a rise in lactate dehydrogenase (LDH) leakage. Glutathione disulfide (GSSG) levels were increased by PAP suggesting the induction of oxidative stress. Western blot analysis confirmed a rise in 4-hydroxynonenal (4-HNE)-adducted proteins in tissues exposed to 0.1 and 0.25 mM PAP for 90 min. The appearance of 4-HNE-adducted proteins at the 0.1 mM concentration of PAP occurred prior to development of increased LDH leakage. Pretreatment with 1 mM glutathione (GSH) for 30 min only partially reduced PAP toxicity as LDH values were less severely depleted relative to tissues not pretreated with GSH. In contrast, pretreatment for 15 min with 2 mM ascorbic acid completely protected against PAP toxicity. Further studies showed that ascorbic acid pretreatment prevented PAP-mediated depletion of GSH. In summary, PAP rapidly depletes GSH and adenine nucleotides and inhibits gluconeogenesis prior to a rise in LDH leakage. PAP induces oxidative stress as indicated by an increase in GSSG and 4-HNE-adducted proteins. Ascorbic acid pretreatment prevents PAP toxicity by maintaining GSH status

  10. The utilization and barriers of Pap smear among women with visual impairment.

    Science.gov (United States)

    Fang, Wen-Hui; Yen, Chia-Feng; Hu, Jung; Lin, Jin-Ding; Loh, Ching-Hui

    2016-04-12

    Many evidences illustrate that the Pap smear screening successfully reduces if the cervical cancer could be detected and treated sufficiently early. People with disability were higher comorbidity prevalence, and less likely to use preventive health care and health promotion activities. There were also to demonstrate that people with visual impairment has less access to appropriate healthcare services and is less likely to receive screening examinations. In Taiwan, there was no study to explore utilization of Pap smear, associated factors and use barriers about Pap smear screening test among women with visual impairment. The purpose is to explore the utilization and barriers of using Pap smear for women with visual impairment in Taiwan. To identify the barriers of women with visual from process of receiving Pap smear screening test. The cross-sectional study was conducted and the totally 316 participators were selected by stratified proportional and random sampling from 15 to 64 year old women with visual impairment who lived in Taipei County during December 2009 to January 2010. The data was been collected by phone interview and the interviewers were well trained before interview. The mean age was 47.1 years old and the highest percentage of disabled severity was mile (40.2 %). Totally, 66.5 % of participators were ever using Pap smear and 38.9 % used it during pass 1 year. Their first time to accept Pap smear was 38.8 year old. There was near 50 % of them not to be explained by professionals before accepting the Pap smear. For non-using cases, the top two percentage of barriers were "feel still younger" (22.3 %), the second was "there's no sexual experience" (21.4 %). We found the gynecology experiences was key factor for women with visual impairment to use Pap smear, especially the experiences was during 1 year (OR = 4). Associated factors and barriers to receive Pap smear screening test for women with visual impairment can be addressed through interventions

  11. Facteurs de risque et dépistage du cancer chez les Premières Nations en Ontario

    Directory of Open Access Journals (Sweden)

    Maegan V. Mazereeuw

    2017-01-01

    égumes au moins deux fois par jour que les hommes et les femmes non autochtones (RT = 0,53 et 0,54, respectivement. La participation au test de Pap était similaire dans tous les groupes, mais les femmes des Premières Nations étaient moins susceptibles que les femmes non autochtones (RT = 0,85 d'avoir subi une mammographie au cours des cinq années précédant l'enquête. Conclusion : Comparativement aux Ontariens non autochtones, les membres des Premières Nations, en particulier ceux qui vivent dans une réserve, présentent un risque accru de cancer et d'autres maladies chroniques. Ces résultats fournissent des éléments probants à l'appui de politiques et de programmes visant à réduire le fardeau futur du cancer et d'autres maladies chroniques chez les Premières Nations en Ontario.

  12. Pap Smear Abnormalities in Women Admitted to a Tertiary Health Center in Southeast Turkey

    Directory of Open Access Journals (Sweden)

    Alev Ozer

    2014-12-01

    Full Text Available Aim: To analyze the cervical cytological abnormalities which are detected in women undergoing Pap screening in a tertiary health care center within Siirt, a southeastern province of Turkey. Material and Method: A total of 3000 women who underwent Pap screening at the study center between January 1, 2009 and December 31, 2009 were recruited for the study. The women who were diagnosed with benign epithelial changes, infectious alterations, as well as atypical squamous cells with undetermined significance (ASC-US, atypical squamous cells of high significance (ASC-H, and low-grade squamous intraepithelial lesion (LSIL were included. Results: Benign epithelial alterations, infectious changes, ASCUS, ASC-H, and LSIL were detected in 83.7%, 15.3%, 0.8%, 0.1% and 0.1% of the Pap smears respectively. A significant correlation was found between the patient age and the histopathological alterations in the Pap smears (r=0.072, p=0.001. Although no correlation could be detected between gravidity and Pap smear results (r=0.033, p=0.067, a significant correlation existed between parity and the histopathological findings within the Pap smears (r=0.051, p=0.005. Interestingly, the Pap smear results were found to be unrelated to socioeconomic status (r=0.088, p=0.168, education level (r=0.048, p=0.257, and smoking habit (r=0.086, p=0.077. Discussion: The present study has reported a value of 1.0% for the overall prevalence of cervical cytological abnormalities, which is much lower than in western countries. Thus, rather than being dependent on the data reported by clinical studies that have been conducted in western countries, Turkish health care policy should be based on the data obtained from national studies.

  13. Experience of the Canary Islands in the development of insular 100% RES systems and micro-grids

    Energy Technology Data Exchange (ETDEWEB)

    Piernavieja, Gonzalo; Suarez, Salvador; Henriquez, Daniel [Instituto Tecnologico de Canarias (Canary Islands Institute of Technology - ITC), Las Palmas, Gran Canaria (Spain). RandD Div.

    2010-07-01

    Given the mentioned circumstances, conventional energy planning in the Canary Islands is a very complex task. The Regional Energy Plan PECAN (2007-2015) tries to correct the existing critical situation setting, among others, the ambitious goal of >25% electricity from RES (mostly wind) for 2015. In parallel to this conventional energy planning, outstanding initiatives in the distributed generation field are underway. ITC vision is that the Canarian Archipelago, given its particular characteristics (insular systems of different sizes, abundant RES potential -different sources-, important natural and biodiversity heritage, etc.), are a laboratory for testing and demonstrating new energy technologies in real conditions, as well as their commercial implementation. These new technologies include energy storage (particularly for excess RES that cannot be absorbed by the grids), development of 100% energy self- sufficiency models (with exclusive use of RES) and micro-/minigrids with high RES penetration and RES forecasting, including advanced ICTs and sustainable mobility concepts (e.g. V2G technologies). Given the high conventional generation costs and the relatively low RES costs (wind electricity production cost is less than 0.03 Euro/kWh), the Canary Islands could in the short term achieve grid parity, and in this sense pioneer the change to a RES based energy system. Models tested on the islands could be exported or extrapolated to our islands, regions of developing countries and even other regions in continental Europe. (orig.)

  14. Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1-adenosine receptors to mediate antinociception.

    Directory of Open Access Journals (Sweden)

    Nathaniel A Sowa

    Full Text Available Prostatic acid phosphatase (PAP is expressed in nociceptive neurons and functions as an ectonucleotidase. When injected intraspinally, the secretory isoforms of human and bovine PAP protein have potent and long-lasting antinociceptive effects that are dependent on A(1-adenosine receptor (A(1R activation. In this study, we purified the secretory isoform of mouse (mPAP using the baculovirus expression system to determine if recombinant mPAP also had antinociceptive properties. We found that mPAP dephosphorylated AMP, and to a much lesser extent, ADP at neutral pH (pH 7.0. In contrast, mPAP dephosphorylated all purine nucleotides (AMP, ADP, ATP at an acidic pH (pH 5.6. The transmembrane isoform of mPAP had similar pH-dependent ectonucleotidase activity. A single intraspinal injection of mPAP protein had long-lasting (three day antinociceptive properties, including antihyperalgesic and antiallodynic effects in the Complete Freund's Adjuvant (CFA inflammatory pain model. These antinociceptive effects were transiently blocked by the A(1R antagonist 8-cyclopentyl-1, 3-dipropylxanthine (CPX, suggesting mPAP dephosphorylates nucleotides to adenosine to mediate antinociception just like human and bovine PAP. Our studies indicate that PAP has species-conserved antinociceptive effects and has pH-dependent ectonucleotidase activity. The ability to metabolize nucleotides in a pH-dependent manner could be relevant to conditions like inflammation where tissue acidosis and nucleotide release occur. Lastly, our studies demonstrate that recombinant PAP protein can be used to treat chronic pain in animal models.

  15. Hubungan Antara Dislipidemia Dengan Status Penyakit Arteri Perifer (Pap) Pada Pasien Diabetes Melitus Tipe 2 Terkontrol Sedang

    OpenAIRE

    Aryani, Eka; Nugroho HS, K. Heri; Margawati, Ani

    2016-01-01

    Latar Belakang: Penyakit arteri perifer adalah gangguan suplai darah ke ekstremitas atas atau bawah karena obstruksi yang disebabkan aterosklerosis. Pasien PAP memiliki risiko yang lebih besar terhadap kematian akibat stroke, infark miokard dan serangan jantung. Diabetes melitus dan dislipidemia merupakan faktor risiko PAP yang sering ditemukan. Belum terdapat penelitian mengenai hubungan dislipidemia dengan status PAP pada pasien DM tipe II terkontrol sedang.Tujuan: Membuktikan hubungan anta...

  16. "It Can Promote an Existential Crisis": Factors Influencing Pap Test Acceptability and Utilization Among Transmasculine Individuals.

    Science.gov (United States)

    Peitzmeier, Sarah M; Agénor, Madina; Bernstein, Ida M; McDowell, Michal; Alizaga, Natalie M; Reisner, Sari L; Pardee, Dana J; Potter, Jennifer

    2017-12-01

    Transmasculine (i.e., female-to-male transgender) individuals have lower rates of cervical cancer screening than nontransgender women and often report negative experiences with the Pap test. Deciding to undergo screening and the test experience itself are characterized by the following processes: negotiating identity as the patient, provider, and insurance company wrestle with the degree of (in)congruence between a patient's masculine gender identity and their conception of the Pap test as feminine; bargaining for health as a Pap test may be required to obtain medical transition services or avoid undesired health outcomes; withstanding acute challenges during the Pap test to body, identity, and privacy; or reframing challenges as affirmation. The degree of distress triggered by the Pap test varied from "routine" to traumatic. Participants affirmed that a trusted, trans-competent health care provider could significantly reduce barriers to regular and satisfactory cervical cancer screening. Data are from 32 in-depth interviews conducted in Boston, Massachusetts, with transmasculine individuals; a modified grounded theory approach informed the analysis.

  17. Relationship Between Pelvic Organ Prolapse and Non-Human Papillomavirus Pap Smear Abnormalities.

    Science.gov (United States)

    Menhaji, Kimia; Harvie, Heidi S; Cheston, Emily; Levin, Pamela J; Arya, Lily A; Andy, Uduak U

    2017-07-13

    The aim of this study was to determine the association between pelvic organ prolapse (POP) and non-human papillomavirus (HPV) Papanicolaou (Pap) smear abnormalities. This was a retrospective cohort study of women aged 40 to 70 years who presented for consultation at our institution between 2010 and 2015 and had results of a Pap smear and HPV test available within 5 years of their visit. We extracted demographic information, medical and social history, Pap smear, and HPV results from the electronic medical record. Associations between the presence of POP and non-HPV Pap smear abnormalities were estimated using univariable and multivariable analyses. We reviewed 1590 charts and excluded 980 women, leaving 610 women in the study: 183 with POP and 427 without POP. Women with POP were significantly older (58.2 ± 7.2 vs 55.6 ± 6.6, P 10 year) history of abnormal Pap smear (24.0% vs 14.8%, P women with POP.

  18. Beliefs about cervical cancer and Pap test: a new Chilean questionnaire.

    Science.gov (United States)

    Urrutia, Maria-Teresa; Hall, Rosemary

    2013-06-01

    The purpose of this study was to develop and validate a questionnaire to examine women's beliefs about cervical cancer and the Pap test in Chilean women. The questionnaire, developed following the guidelines by Robert de Vellis, is based on the Health Belief Model. The content validity index was 0.93 upon review by 10 Chilean experts. A cross-sectional design was implemented to validate the questionnaire. The sample included 333 women recruited from a women's healthcare center in Santiago, Chile. Exploratory factor analysis was used to evaluate validity and coefficient α to evaluate reliability. After six models were computed, the questionnaire was reduced from 53 to 28 items. The new questionnaire, CPC-28 (in Spanish, Creencias, Papanicolaou, Cancer -28), includes six domains: the barriers domain to take a Pap test, the cues to action domain, the severity domain, the need to have a Pap test domain, the susceptibility to cervical cancer domain, and the benefit domain. The unexpected salient factor "need to have a Pap test" was found as part of the susceptibility domain proposed in the initial questionnaire. This finding is an important topic for future research. The CPC-28 questionnaire explained 49% of the total variance, and the reliability was .735. It was concluded that the CPC-28 questionnaire will have important implications on research, education, and administration across disciplines. Nursing curricula and healthcare providers must stress the importance and reinforce the importance of prevention of cervical cancer and regular Pap test screenings. © 2013 Sigma Theta Tau International.

  19. Pap Screening Goals and Perceptions of Pain among Black, Latina, and Arab Women: Steps toward Breaking down Psychological Barriers

    Science.gov (United States)

    Gauss, Julie W.; Mabiso, Athur; Williams, Karen Patricia

    2013-01-01

    BACKGROUND Understanding women’s psychological barriers to getting Papanicolaou (Pap) screening has potential to impact cancer disparities. This study examined pain perceptions of Pap testing among Black, Latina and Arab women and goal setting to receive Pap tests. METHODS Data on 420 women, a longitudinal study, were analyzed using Chi-square tests of differences and generalized linear mixed models. RESULTS At baseline, 30.3% of Black and 35.5% of Latina women perceived Pap tests to be very painful compared to 24.2% of Arab women. Perceptions of pain influenced goal settings, such as scheduling a first ever Pap test (Odds ratio = 0.58, 95% Confidence interval: 0.14-0.94). Immediately following the intervention, women’s perception that Pap tests are very painful significantly declined (P-valuetest is very painful significantly reduces the likelihood of Black, Latina and Arab women setting the goal to schedule their first ever Pap test. Latina women are the least likely to improve their perception that the Pap test is very painful, though national statistics show they have the highest rates of morbidity and mortality from cervical cancer. These findings are instructive for designing tailored interventions to break down psychological barriers to Pap screening among underserved women. PMID:23288606

  20. Importance of a 5′ Stem-Loop for Longevity of papA mRNA in Escherichia coli

    OpenAIRE

    Bricker, Angela L.; Belasco, Joel G.

    1999-01-01

    High-level expression of the major pilus subunit (PapA) of uropathogenic strains of Escherichia coli results in part from the unusually long lifetime of the mRNA that encodes this protein. Here we report that the longevity of papA mRNA derives in large measure from the protection afforded by its 5′ untranslated region. This papA RNA segment can prolong the lifetime of an otherwise short-lived mRNA to which it is fused. In vivo alkylation studies indicate that, in its natural milieu, the papA ...

  1. Quantificação de resíduos sólidos na drenagem urbana

    OpenAIRE

    Marllus Gustavo Ferreira Passos das Neves

    2006-01-01

    O objetivo deste trabalho é quantificar os resíduos sólidos que atingem a rede de drenagem de águas pluviais, isto é, plásticos, vidros, papéis e outros que podem ter destinação mais adequada do que a mais comum nos países em desenvolvimento: cursos d’água, ruas e outros locais inadequados. A quantificação do lixo foi realizada a partir da pesagem do material que atingiu o poço da casa de bombas de número 12, situada o parque Marinha do Brasil em Porto Alegre. Logo a montante desta casa de bo...

  2. The purifying bridge of Res Publica / Rein Taagepera

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2004-01-01

    Res Publica edust Eesti poliitilisel maastikul. Autor käsitleb Res Publicat kui puhastava toimega ja silla funktsiooni täitvat parteid, mis üritab siduda tervikuks Keskerakonna ja Reformierakonna seisukohad

  3. Parts ei soovi Res Publica esimehe ametit / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2005-01-01

    Kõige tõenäolisem kandidaat Res Publica juhi kohale on Taavi Veskimägi, aseesimeesteks kandideerivad Marko Mihkelson ja Henn Pärn. Res Publica fraktsiooni koosolekul leidis Mihhail Lotman, et erakond võiks olla feminiinsem

  4. Res Publica meelitab valla- ja linnajuhte / Henrik Roonemaa

    Index Scriptorium Estoniae

    Roonemaa, Henrik

    2001-01-01

    Valitsusliidu regionaalpoliitikas pettunud 30 omavalitsusjuhti on astunud ühenduse Res Publica liikmeks, lootes selle põhjal tekkiva partei abil kohaliku ja riigivõimu taas omavahel suhtlema panna. Vt. samas Res Publica liikmetest omavalitsusjuhid

  5. Juhan Parts soovib Res Publica tagasi tippu viia / Toomas Sildam

    Index Scriptorium Estoniae

    Sildam, Toomas, 1961-

    2004-01-01

    Res Publica esimees peaminister Juhan Parts plaanib minna oma erakonnaga kohalikele valimistele ning uurib võimalusi paremerakondade ühinemiseks. Rakveres toimunud erakonna üldkogust. Lisad: Peaministri neli rasket hetke; Res Publica ministrid said parteilt toetuse. Vt. samas: Reformierakond kiitis Res Publicat hea koostöö eest; Parts: 191 vastuhäält on hea tulemus

  6. Kes tegelikult lõid Res Publica? / Valeri Kalabugin

    Index Scriptorium Estoniae

    Kalabugin, Valeri

    2005-01-01

    Enne erakonnaks kuulutamist oli Res Publica Eesti iseseisvust ja demokraatiat taotlev ühendus, kuhu on kuulunud mitmed poliitika- ning ühiskonnategelased. Vt. samas: Ühendus Res Publica avaldus. Küsimustele vastavad Res Publica avalike suhete juht Riina Vändre, Riigikogu liige Mart Nutt, ajakirjanik Toomas Kümmel

  7. Pneumocephalus with BiPAP use after transsphenoidal surgery☆,☆☆,★

    Science.gov (United States)

    Kopelovich, Jonathan C.; de la Garza, Gabriel O.; Greenlee, Jeremy D.W.; Graham, Scott M.; Udeh, Chiedozie I.; O'Brien, Erin K.

    2013-01-01

    While the benefits of continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BiPAP) for patients with obstructive sleep apnea are well described, reports in the literature of complications from its use are rare. A patient who received postoperative BiPAP after undergoing transsphenoidal craniopharyngioma resection developed severe pneumocephalus and unplanned intensive care unit admission. Although the pneumocephalus resolved with conservative management over two weeks, we propose caution in the use of CPAP postoperatively in patients undergoing procedures of the head and neck. PMID:22626688

  8. Awareness and practice of cervical cancer and Pap smear testing in a teaching hospital in Tehran

    Directory of Open Access Journals (Sweden)

    Mansoureh Ghaoomi

    2016-06-01

    Full Text Available Background: Cervical cancer is known to be preventable because of long period of pre-invasive stage, availability of screening tools, and effective treatments for early invasive cervical lesions. Screening is main measures to prevent the disease and Pap smear is a screening strategy for cervical cancer. Current paper aimed to evaluate levels of awareness and practice regarding Pap smear screening among women aged between 20 to 65 years in Tehran (Iran. Methods: This was a descriptive-analytical study conducted in Tehran City of Iran in 2015 at Firoozgar Hospital. The research population included all married, widowed and divorced women aged 20-65 years. Data analysis was performed using the Pearson correlation and Student’s t-tests in SPSS, ver. 23 (Chicago, IL, USA. Results: Among 90 individuals who have fill questionnaire completely, 66.6% subjects had Pap smear tests. 40% of the individuals aged between 30 to 39 and the education level is distributed equally between Intermediate, Diploma and graduate and only 3 percent of them, continue their education to higher level. There was a significant relationship between the awareness of Pap smear and educational level (of both wives and husbands. The people who have graduate degree, have the best awareness. Working women revealed higher level of awareness about Pap smear. Shame and fear of taking the cancer were the most common reasons which lead to avoidance in doing the test by the women, while the most encouraging factors for performing the test were the information mostly provided by physicians and after that, the information provided by friends. Conclusion: The awareness of Pap smear test which was measured by weighting different questions in the questionnaire by experts, prove that the women aged above 39, have an average level of awareness of Pap smear test. Due to high prevalence of cervical cancer and prolonged pre invasive course, role of Pap smear for early diagnosis necessitate the use

  9. Pap-smear Classification Using Efficient Second Order Neural Network Training Algorithms

    DEFF Research Database (Denmark)

    Ampazis, Nikolaos; Dounias, George; Jantzen, Jan

    2004-01-01

    In this paper we make use of two highly efficient second order neural network training algorithms, namely the LMAM (Levenberg-Marquardt with Adaptive Momentum) and OLMAM (Optimized Levenberg-Marquardt with Adaptive Momentum), for the construction of an efficient pap-smear test classifier. The alg......In this paper we make use of two highly efficient second order neural network training algorithms, namely the LMAM (Levenberg-Marquardt with Adaptive Momentum) and OLMAM (Optimized Levenberg-Marquardt with Adaptive Momentum), for the construction of an efficient pap-smear test classifier...

  10. Comparison of Pap smear screening results between Akha hill tribe and urban women in Chiang Rai province, Thailand.

    Science.gov (United States)

    Kritpetcharat, Onanong; Wutichouy, Wiwat; Sirijaichingkul, Suchat; Kritpetcharat, Panutas

    2012-01-01

    Cervical cancer is an important woman's health problems worldwide, especially in low socio-economic countries. The aim of this study was to compare the Pap smear screening results between Akha hill tribe and urban women who live in Chiang Rai province, Thailand. Screening was conducted for 1,100 Akha women and 1,100 urban women who came to have the Pap smear at Chiangrai Prachanukroh Hospital and 1 private cytology laboratory from January to June 2008. The demographic characteristics and factors related to abnormal Pap smears of these women were gathered using closed model questionnaires. Abnormal Rap smears were defined according to the Bethesda 2001 system. The results showed that the prevalence of abnormal Pap smears was 12.2% in Akha women and 4.5% in urban women. The highest prevalence of Pap abnormalities was found in the 41-50 years age group in both populations (4.5% in Akha and 1.7% in urban women). In both populations, abnormal Pap smears were found in education level. In conclusion, cervical cancer control by education and early detection by Pap smear screening is necessary for hill tribe women. More Pap smear screening service units should be set to improve the coverage for the risk group women who got married in young age, especial in ethnic groups.

  11. CNS activity of Pokeweed Anti-viral Protein (PAP in mice infected with Lymphocytic Choriomeningitis Virus (LCMV

    Directory of Open Access Journals (Sweden)

    Tibbles Heather E

    2005-02-01

    Full Text Available Abstract Background Others and we have previously described the potent in vivo and in vitro activity of the broad-spectrum antiviral agent PAP (Pokeweed antiviral protein against a wide range of viruses. The purpose of the present study was to further elucidate the anti-viral spectrum of PAP by examining its effects on the survival of mice challenged with lymphocytic choriomeningitis virus (LCMV. Methods We examined the therapeutic effect of PAP in CBA mice inoculated with intracerebral injections of the WE54 strain of LCMV at a 1000 PFU dose level that is lethal to 100% of mice within 7–9 days. Mice were treated either with vehicle or PAP administered intraperitoneally 24 hours prior to, 1 hour prior to and 24 hours, 48 hours 72 hours and 96 hours after virus inoculation. Results PAP exhibits significant in vivo anti- LCMV activity in mice challenged intracerebrally with an otherwise invariably fatal dose of LCMV. At non-toxic dose levels, PAP significantly prolonged survival in the absence of the majority of disease-associated symptoms. The median survival time of PAP-treated mice was >21 days as opposed to 7 days median survival for the control (p = 0.0069. Conclusion Our results presented herein provide unprecedented experimental evidence that PAP exhibits antiviral activity in the CNS of LCMV-infected mice.

  12. Star-PAP Control of BIK Expression and Apoptosis Is Regulated by Nuclear PIPKIα and PKCδ Signaling

    Science.gov (United States)

    Li, Weimin; Laishram, Rakesh S.; Ji, Zhe; Barlow, Christy A.; Tian, Bin; Anderson, Richard A.

    2012-01-01

    SUMMARY BIK protein is an initiator of mitochondrial apoptosis and BIK expression is induced by pro-apoptotic signals including DNA damage. Here we demonstrate that 3′-end processing and expression of BIK mRNA are controlled by the nuclear PI4,5P2-regulated poly(A) polymerase Star-PAP downstream of DNA damage. Nuclear PKCδ is a key mediator of apoptosis and DNA damage stimulates PKCδ association with the Star-PAP complex where PKCδ is required for Star-PAP-dependent BIK expression. PKCδ binds the PI4,5P2-generating enzyme PIPKIα, which is essential for PKCδ interaction with the Star-PAP complex and PKCδ activity is directly stimulated by PI4,5P2. Features in the BIK 3′-UTR uniquely define Star-PAP specificity and may block canonical PAP activity toward BIK mRNA. This reveals a nuclear phosphoinositide signaling nexus where PIPKIα, PI4,5P2 and PKCδ regulate Star-PAP control of BIK expression and induction of apoptosis. This pathway is distinct from the Star-PAP-mediated oxidative stress pathway indicating signal-specific regulation of mRNA 3′-end processing. PMID:22244330

  13. Farm Shop : Augmenter l'accès aux matières premières agricoles au ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Farm Shop est un modèle de franchise social novateur qui permet d'obtenir des matières premières d'excellente qualité à des prix abordables grâce à des économies d'échelle. Il forme également des franchisés et des agriculteurs sur la façon d'utiliser les matières premières. Au cours de ses trois premières années ...

  14. Generation of Anomalous Internal Pressures in Source Rocks and Its Role in Driving Petroleum Migration La genèse de pressions internes anormales dans les roches mères et son rôle de poussée dans la migration du pétrole

    Directory of Open Access Journals (Sweden)

    Barker C.

    2006-11-01

    Full Text Available High pressures generated within shales probably have an important role in driving the expulsion of oil and gas. The rising temperature that accompanies increasing depth of burial and drives the generation process causes thermal expansion of the water and in an isolated pore aquathermal pressuringcan lead to high overpressures. In addition, the generation process itself seems to proceed with a volume increase that can cause very high overpressures. These mechanisms have been discussed previously only for liquid-filled systems. The presence of gas leads to very different behaviour and pores in source rocks become subnormally pressured on burial unless there is sufficient generation from the organic matter to offset this. In the absence of continuing generation (e. g. for biogenic methane gas steadily dissolves and pressures fall considerably below hydrostatic. Conversely, on uplift gas-bearing systems tend to overpressure and the pressure can rise to the rock load for the depth when fracturing must occur. Thermal cracking of the bitumens that remain in a source rock as it is buried goes with a volume increase, and in an isolated pore system pressures rise to high values. Only about one percent of oil-like butimen needs to be cracked to gas for the pressure to reach the rock load with fracturing as an inevitable consequence. Les pressions élevées générées dans les argiles jouent probablement un rôle important dans l'expulsion de l'huile et du gaz. L'augmentation de température, qui accompagne l'enfouissement et contrôle les processus de genèse, est la cause d'une dilatation thermique de l'eau et, dans un pore isolé, l'aquathermal pressuring peut amener des surpressions élevées. De plus, le processus de genèse lui-même semble être accompagné d'une augmentation de volume pouvant être également la cause de surpressions élevées. Ces mécanismes ont déjà fait l'objet d'études, mais seulement pour des systèmes imbibés de liquides

  15. How Often to Get a Pap Test (A Minute of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2013-01-10

    Cervical cancer has declined in the U.S., however every year over 12,000 women are diagnosed and 4,000 die. This podcast discusses the importance of Pap testing.  Created: 1/10/2013 by MMWR.   Date Released: 1/10/2013.

  16. Pap screening as preventive tool against cervical cancer: a report of ...

    African Journals Online (AJOL)

    The incidence of cervical cancer in the developed countries has significantly reduced as a result of well-organized and coordinated Pap screening program, which is aimed at detection of pre-invasive lesions that are then promptly treated. We report a 45-year old woman whose immediate elder sister had breast carcinoma, ...

  17. Papshop: Not a 'melon'choly Pap smear workshop! | Gordon | South ...

    African Journals Online (AJOL)

    As Head of Undergraduate Education in the Department of Obstetrics and Gynaecology at the University of Cape Town, South Africa, I have a particular interest in the competencies needed to perform primary care gynaecological procedures, one of which is the Pap smear. I was approached by a group of keen volunteer ...

  18. Evaluating the Pap Smear Reports of Pathology Laboratories in Ahvaz, Iran

    Directory of Open Access Journals (Sweden)

    Shirin Zargar Shoushtari

    2016-07-01

    Full Text Available Background & aim: Pap smear is a screening procedure for cervical cancer. The incidence and mortality rate of cervical cancer has decreased up to 90% in the regular screening in women aged 20-65 years. This study aimed to investigate the Pap smear reports of pathology laboratories in Ahvaz, Iran. Methods: In this cross-sectional study, 1,006 Pap smear reports were collected from pathology laboratories via cluster sampling method. Data was analyzed by a self-structured questionnaire. In addition, variables such as age, type of infection, grade of inflammation, metaplastic changes, and epithelial cell abnormalities in cervix were studied in this study. Data analysis was performed in SPSS V.16.0 using descriptive analysis, ANOVA, Fisher’s exact, and Chi-square tests. Results: While no infection was reported in 94.43% (n=950 of cases, the highest incidence rate of infections in the remaining samples (5.56%, n=56 was related to Candida Albicans (4.77%, n=48. Various grades of inflammation were reported in 83.69% (n=842 of the samples. Moreover, the highest grade of inflammation in fungal infections was 2+, whereas the grades in Trichomonas and bacterial infections were 1+ and 3+, respectively. Cervical dysplasia and metaplasia were reported in 0.29% (n=3 and 1.19% (n=12 of the cases, respectively. Conclusion: The prevalence of cervical-vaginal infections, cervical metaplasia, and dysplasia were relatively low in Pap smear reports of laboratories in Ahvaz.

  19. .\tA Study on Cervical Pap Smear Examination in Patient Living with HIV.

    Directory of Open Access Journals (Sweden)

    Dr. Devanshi Gosai

    2016-12-01

    Full Text Available Background: Extensive screening programme of cervical Pap smear examination can detect the precancerous and cancerous lesions at an early stage and mortality & morbidity due to these lesions can be reduced. HPV infection is a known etiological agent for cervical cancer. HIV infected women are at higher risk of contracting HPV infection due to immune compromised status. Objective: Present study has been undertaken mainly to detect precancerous & cancerous lesions as well as inflammatory lesions in female patients living with HIV & to emphasize the fact that Pap smear examination should be established as a part of routine protocol for examination in HIV infected women. Methods: The study was carried out on 369 HIV infected females attending Integrated Counselling &Testing Centre of government institute. As controls, 142 females (not falling under high risk category, attending the Obstetrics& Gynaecology OPD with various gynaecological complaints were taken & results were compared. Results: Squamous cell abnormalities were found about four times high as compared to control group. High incidences of squamous cell abnormalities were noted in patients with high parity (parity three or more. Conclusion: Regular gynaecological examination including Pap smear examinations is highly recommended for HIV infected females. Pap smear examination is a simple, cheap, safe & practical diagnostic tool for early detection of cervical cancer in high risk population.

  20. Frequency and patterns of abnormal Pap smears in Sudanese women with infertility: What are the perspectives?

    Directory of Open Access Journals (Sweden)

    Ahmed O Almobarak

    2013-01-01

    Conclusions: Epithelial cell abnormalities are significantly higher in women with infertility as compared with fertile women. Importantly, inflammatory smears were reported two times more than in the controls. We recommend pap smear as a routine practice for all women assessed for infertility problems. Further studies are necessary to evaluate the incidence of human papilloma virus infections in infertile women with abnormal cervical cytology.

  1. Psychological impact, support and information needs for women with an abnormal Pap smear: comparative results of a questionnaire in three European countries

    Directory of Open Access Journals (Sweden)

    Jorge Anna

    2011-05-01

    Full Text Available Abstract Background Extensive information on cervical cancer is currently available. Its effectiveness in reducing anxiety in women receiving abnormal Pap tests is not clear. We investigated current practices of communicating abnormal Pap results to evaluate women's reactions and determine the sources of information they use subsequently. Methods A self-administered questionnaire-based study was performed in 1475 women in France, Spain and Portugal who had received an abnormal Pap smear result in the 12 months prior to completing the questionnaire. Questions covered methods of communication of the result, emotional reactions, support received (from the physician and entourage, and information sources, using pre-specified check box options and rating scales. Data were analyzed by country. Results Pap test results were mostly communicated by phone to Spanish women (76%, while physician letters were common in France (59% and Portugal (36%. Frequent reactions were anxiety, panic and stress, which were less common in Spanish women than their French and Portuguese counterparts. After discussing with their physician, half of the participants were worried, despite rating highly the psychological support received. Over 90% of women in each country discussed their results with family or friends. Partners provided a high level of support. Overall, the abnormal diagnosis and consequences had a low to medium impact on daily, professional and family life and their relationships with their partner. Impact was higher in Spanish women than the French or Portuguese. Information on the diagnosis and its treatment was rated average, and nearly 80% of participants wanted more information, notably French women. Preferred sources were the physician and the Internet. Conclusions Women expressed a strong wish for more information about cervical cancer and other HPV-related diseases, and that their physician play a major role in its provision and in support. There was a

  2. CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing

    International Nuclear Information System (INIS)

    Maita, Hiroshi; Kitaura, Hirotake; Ariga, Hiroyoshi; Iguchi-Ariga, Sanae M.M.

    2005-01-01

    We have reported that PAP-1, a product of a causative gene for autosomal retinitis pigmentosa, plays a role in splicing. In this study, CIR, a protein originally identified as a CBF1-interacting protein and reported to act as a transcriptional corepressor, was identified as a PAP-1 binding protein and its function as a splicing factor was investigated. In addition to a basic lysine and acidic serine-rich (BA) domain and a zinc knuckle-like motif, CIR has an arginine/serine dipeptide repeat (RS) domain in its C terminal region. The RS domain has been reported to be present in the superfamily of SR proteins, which are involved in splicing reactions. We generated CIR mutants with deletions of each BA and RS domain and studied their subcellular localizations and interactions with PAP-1 and other SR proteins, including SC35, SF2/ASF, and U2AF 35 . CIR was found to interact with U2AF 35 through the BA domain, with SC35 and SF2/ASF through the RS domain, and with PAP-1 outside the BA domain in vivo and in vitro. CIR was found to be colocalized with SC35 and PAP-1 in nuclear speckles. Then the effect of CIR on splicing was investigated using the E1a minigene as a reporter in HeLa cells. Ectopic expression of CIR with the E1a minigene changed the ratio of spliced isoforms of E1a that were produced by alternative selection of 5'-splice sites. These results indicate that CIR is a member of the family of SR-related proteins and that CIR plays a role in splicing regulation

  3. Temas das Brincadeiras de Papéis na Educação Infantil

    Directory of Open Access Journals (Sweden)

    Suzana Marcolino

    Full Text Available O objetivo do artigo é discutir os temas da brincadeira de papéis sociais na Educação Infantil, revelados por meio de análise conduzida com base nos estudos da Psicologia Histórico-Cultural. Para Elkonin, na idade pré-escolar a brincadeira atinge o auge de seu desenvolvimento, e se caracteriza pela criação de uma situação imaginária, pela presença de regras e de papéis sociais. Foram observadas situações de brincadeira de crianças de quatro anos e meio a cinco anos e meio em 11 escolas da rede municipal de uma cidade de médio porte do interior paulista. A partir do registro das observações, foram identificadas 27 cenas de brincadeira de papéis. A análise dos dados colhidos confirma a tese de Elkonin de que o desenvolvimento da brincadeira de papéis relaciona-se com o que a criança conhece de sua realidade, e indica a necessidade do estabelecimento de certas condições para que esse desenvolvimento ocorra na Educação Infantil. Nesse sentido, discute-se a necessidade de uma mediação do professor calcada na compreensão da riqueza de implicações que a brincadeira de papéis tem para a formação da pessoa.

  4. RES-E-NEXT: Next Generation of RES-E Policy Instruments

    Energy Technology Data Exchange (ETDEWEB)

    Miller, M.; Bird, L.; Cochran, J.; Milligan, M.; Bazilian, M. [National Renewable Energy Laboratory, Golden, CO (United States); Denny, E.; Dillon, J.; Bialek, J.; O’Malley, M. [Ecar Limited (Ireland); Neuhoff, K. [DIW Berlin (Germany)

    2013-07-04

    The RES-E-NEXT study identifies policies that are required for the next phase of renewable energy support. The study analyses policy options that secure high shares of renewable electricity generation and adequate grid infrastructure, enhance flexibility and ensure an appropriate market design. Measures have limited costs or even save money, and policies can be gradually implemented.

  5. Sources

    International Nuclear Information System (INIS)

    Duffy, L.P.

    1991-01-01

    This paper discusses the sources of radiation in the narrow perspective of radioactivity and the even narrow perspective of those sources that concern environmental management and restoration activities at DOE facilities, as well as a few related sources. Sources of irritation, Sources of inflammatory jingoism, and Sources of information. First, the sources of irritation fall into three categories: No reliable scientific ombudsman to speak without bias and prejudice for the public good, Technical jargon with unclear definitions exists within the radioactive nomenclature, and Scientific community keeps a low-profile with regard to public information. The next area of personal concern are the sources of inflammation. This include such things as: Plutonium being described as the most dangerous substance known to man, The amount of plutonium required to make a bomb, Talk of transuranic waste containing plutonium and its health affects, TMI-2 and Chernobyl being described as Siamese twins, Inadequate information on low-level disposal sites and current regulatory requirements under 10 CFR 61, Enhanced engineered waste disposal not being presented to the public accurately. Numerous sources of disinformation regarding low level radiation high-level radiation, Elusive nature of the scientific community, The Federal and State Health Agencies resources to address comparative risk, and Regulatory agencies speaking out without the support of the scientific community

  6. Revisiting support policies for RES-E adulthood: Towards market compatible schemes

    International Nuclear Information System (INIS)

    Huntington, Samuel C.; Rodilla, Pablo; Herrero, Ignacio; Batlle, Carlos

    2017-01-01

    The past two decades of growth in renewable energy sources of electricity (RES-E) have been largely driven by out-of-market support policies. These schemes were designed to drive deployment on the basis of specific subsidies sustained in time to allow for the larger costs as well as to limit investor risk. While these policies have proven to be effective, the way they have been designed to date has led to costly market distortions that are becoming more difficult to ignore as penetrations reach unpreceded levels. In the context of this growing concern, we provide a critical analysis of the design elements of RES-E support schemes, focusing on how they affect this trade-off between promoting and efficiently integrating RES-E. The emphasis is on the structure of the incentive payment, which in the end turns to be the cornerstone for an efficient integration. We conclude that, while needed, a well-designed and further developed capacity-based support mechanism complemented with ex-post compensations defined for reference benchmark plants, such as the mechanism currently implemented in Spain, is an alternative with good properties if the major goal is truly market integration. The approach is robust to future developments in technology cost, performance and market penetration of RES-E. - Highlights: • Market distortions due to RES support mechanisms are becoming difficult to ignore. • This paper provides a critical analysis of the design elements of RES support schemes. • The emphasis is on the structure of the incentive, key for an efficient integration. • We argue in favor of a further developed capacity-based support mechanism. • The incentive should be combined with the design of a set of reference plants.

  7. Knowledge and acceptability of pap smears, self-sampling and HPV vaccination among adult women in Kenya.

    Directory of Open Access Journals (Sweden)

    Anne F Rositch

    Full Text Available Our study aimed to assess adult women's knowledge of human papillomavirus (HPV and cervical cancer, and characterize their attitudes towards potential screening and prevention strategies.Women were participants of an HIV-discordant couples cohort in Nairobi, Kenya. An interviewer-administered questionnaire was used to obtain information on sociodemographic status, and sexual and medical history at baseline and on knowledge and attitudes towards Pap smears, self-sampling, and HPV vaccination at study exit.Only 14% of the 409 women (67% HIV-positive; median age 29 years had ever had a Pap smear prior to study enrollment and very few women had ever heard of HPV (18%. Although most women knew that Pap smears detect cervical cancer (69%, very few knew that routine Pap screening is the main way to prevent ICC (18%. Most women reported a high level of cultural acceptability for Pap smear screening and a low level of physical discomfort during Pap smear collection. In addition, over 80% of women reported that they would feel comfortable using a self-sampling device (82% and would prefer at-home sample collection (84%. Nearly all women (94% reported willingness to be vaccinated to prevent cervical cancer if offered at no or low cost.These findings highlight the need to educate women on routine use of Pap smears in the prevention of cervical cancer and demonstrate that vaccination and self-sampling would be acceptable modalities for cervical cancer prevention and screening.

  8. Afrique : ressources minières, environnement et gouvernance ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    25 janv. 2011 ... ils regorgent de richesses inouïes », assure Bonnie Campbell, directrice du Groupe de recherche sur les activités minières en Afrique (GRAMA) et titulaire de la Chaire C.-A. Poissant de recherche sur la gouvernance et l'aide au développement, faisant référence aux ressources minières et pétrolières dont ...

  9. Cervical screening program and the psychological impact of an abnormal Pap smear: a self-assessment questionnaire study of 590 patients.

    Science.gov (United States)

    Thangarajah, Fabinshy; Einzmann, Thomas; Bergauer, Florian; Patzke, Jan; Schmidt-Petruschkat, Silke; Theune, Monika; Engel, Katja; Puppe, Julian; Richters, Lisa; Mallmann, Peter; Kirn, Verena

    2016-02-01

    Invasive cervical cancer is today the fourth most common cancer of women in western civilization. Screening programs have led to a continuously decrease. Nevertheless, both screening and a positive test result are known to be associated with a negative psychological impact. Screening programs in European countries differ and thus psychological impact might as well. The aim of this study was to evaluate the psychological impact of women with an abnormal Pap smear in a German cohort. Between July 2013 and May 2014, a self-assessment questionnaire was distributed to 595 patients that were referred to a special clinic for cervical dysplasia for further evaluation of an abnormal Pap smear. Patients were recruited in five different centers. Most patients (45.9 %) were informed about the test result via phone call by their doctor. 68.8 % of the patients felt anxious and 26.3 % even felt panic. After having talked to their physician, 51.4 % of our cohort still felt worried and only 24.4 % felt reassured. Concerning disease management, 48.4 % underwent a control Pap smear in 6 months. The preferred information source was the physician (63.9 %). Compared to the results in other European countries, our study cohort showed differences concerning age distribution, patients living in a partnership, number of children and especially disease management. Cancer screening itself and abnormal test results have an impact on patient's feelings. To reduce the psychological impact, patients need to be better informed about the risks and benefits of cancer screening programs and in case of cervical cancer screening about the meaning of an abnormal test result. Our results underline the importance of a trustful physician-patient relationship in that matter.

  10. Resúmenes de proyectos de grado

    Directory of Open Access Journals (Sweden)

    Revista Ingeniería e Investigación

    2002-01-01

    Full Text Available Para la Facultad de Ingeniería de la Universidad Nacional de Colombia sede Bogotá los trabajos desarrollados por los estudiantes con la dirección de docentes como condición para obtener su título profesional, expresan la dinámica de las investigaciones y las áreas de conocimiento en la que están comprometidos los diferentes estamentos de la facultad, Es por esta razón que la revista Ingeniería e Investigación comenzará a publicar, a partir de la fecha los resúmenes de los trabajos de pregrado y las tesis de posgrado que permanentemente se están desarrollando en la Facultad de Ingeniería.

  11. A Study on Cervical Cancer Screening Using Pap Smear Test and Clinical Correlation

    Directory of Open Access Journals (Sweden)

    Pushp Lata Sachan

    2018-01-01

    Full Text Available Objective: The objective of the study is to evaluate the use of the Pap smear screening method for detection of precancerous lesions. Methods: All women who visited the outpatient gynecology clinic of the Department of Obstetrics and Gynaecology at King Georges Medical University, Lucknow, UP, India, over 1 year for different clinical problems were recruited for the study. A total of 1650 women who were sexually active and over 21 years of age were enrolled in the study. A clinical examination, an examination per speculum, and a vaginal examination were performed and a history taken for all women. A Pap smear was used for all women to screen for cervical cancer. The smear was obtained using an Ayre spatula and spread over a marked glass slide, which was placed in 95% ethyl alcohol and sent to the Department of Pathology for cytopathological examination. All data were recorded using a predetermined pro forma. Women who had visible malignant cervical lesions were excluded from the study. Results: Most women were in the age range of 30–50 years and multiparous. Vaginal discharge was the most common complaint, occurring in 36.96% of the women. An irregular menstrual cycle was the complaint of 12.78% and abdominal pain of 25.63% of women, while 15.15% were asymptomatic. The Pap smear test of 93.57% of the women was adequately taken, while 6.42% of the individuals had an inadequate sample. The test was negative for malignancy in 48.84%, and 42.66% had infection or inflammation. Atypical squamous cells of undetermined significance (ASCUS, low-grade squamous intraepithelial lesion (LSIL, and high-grade squamous intraepithelial lesion (HSIL were detected in 2.90%, 5.09%, and 0.48%, respectively. Women with Pap tests positive for ASCUS, LSIL, and HSIL underwent a colposcopy and guided biopsy. Conclusions: Women with an abnormal Pap test should undergo a colposcopy, and those with abnormal colposcopy findings should be advised to undergo a biopsy. A Pap

  12. Frequency and organization of papA homologous DNA sequences among uropathogenic digalactoside-binding Escherichia coli strains.

    OpenAIRE

    Denich, K; Craiu, A; Rugo, H; Muralidhar, G; O'Hanley, P

    1991-01-01

    The frequency of selected papA DNA sequences among 89 digalactoside-binding, uropathogenic Escherichia coli strains was evaluated with 12 different synthetic 15-base probes corresponding to papA genes from four digalactoside-binding piliated recombinant strains (HU849, 201B, and 200A). The papA probes encode amino acids which are common at the carboxy terminus of all strains, adjacent to the proximal portion of the intramolecular disulfide loop of strain 210B, or predicted to constitute the t...

  13. Aproveitamento do resíduo da produção de etanol a partir de farelo de mandioca, como fonte de fibras dietéticas Utilization of the residue of the ethanol production from cassava fibrous waste, as source for fibre

    Directory of Open Access Journals (Sweden)

    M. LEONEL

    1999-05-01

    Full Text Available O presente trabalho teve por objetivo analisar resíduos do farelo de mandioca resultantes de processos de hidrólise enzimática para obtenção de etanol; visando o aproveitamento destes como fonte de fibras dietéticas. Foram realizados quatro ensaios enzimáticos utilizando as enzimas amilolíticas, a-amilase e amiloglucosidase, complementadas ou não com celulase e/ou pectinase. Os resíduos foram caracterizados quanto à composição centesimal, pH, acidez, perfil de açúcares e quanto às fibras (FDA, FDN, celulose, hemicelulose, lignina, açúcares neutros. Realizou-se também a análise microscópica dos resíduos. Pelos resultados obtidos na caracterização dos resíduos calculou-se a energia metabolizável aparente (EM. Observou-se que independente do ensaio enzimático todos os resíduos podem ser usados como fonte de fibras insolúveis. Os resíduos resultantes dos ensaios com pectinase apresentaram uma proporção aproximada de 1:1:1 de amido, fibras e açúcares, sendo a glicose o açúcar majoritário, e com energia metabolizável aparente de cerca de 2,6 kcal/g. Já os resíduos, onde não se utilizou a pectinase a proporção foi de 2:1:1 aproximadamente e a energia 3,1 kcal/g. A análise microscópica dos resíduos mostrou a presença de amido não hidrolisado preso às células em todos os ensaios enzimáticos sendo que, nos resíduos dos ensaios com pectinase a quantidade observada foi bem inferior aos demais. Uma possível alternativa para diminuir o valor calórico dos resíduos seria a lavagem com água após a prensagem para extração do hidrolisado para fermentação.The research had as propose to evaluate the residues of the enzymatic hydrolysis process of the ethanol production from cassava fibrous waste by dietetic fibers. Four hydrolysis process were carried out using the amylases, a-amylase and amyloglucosidase, with or without pectinase and/or cellulase. Proximate percent composition, pH, acidity, sugars and

  14. sources

    Directory of Open Access Journals (Sweden)

    Shu-Yin Chiang

    2002-01-01

    Full Text Available In this paper, we study the simplified models of the ATM (Asynchronous Transfer Mode multiplexer network with Bernoulli random traffic sources. Based on the model, the performance measures are analyzed by the different output service schemes.

  15. Drastic anthocyanin increase in response to PAP1 overexpression in fls1 knockout mutant confers enhanced osmotic stress tolerance in Arabidopsis thaliana.

    Science.gov (United States)

    Lee, Won Je; Jeong, Chan Young; Kwon, Jaeyoung; Van Kien, Vu; Lee, Dongho; Hong, Suk-Whan; Lee, Hojoung

    2016-11-01

    KEY MESSAGE : pap1 - D/fls1ko double mutant plants that produce substantial amounts of anthocyanin show tolerance to abiotic stress. Anthocyanins are flavonoids that are abundant in various plants and have beneficial effects on both plants and humans. Many genes in flavonoid biosynthetic pathways have been identified, including those in the MYB-bHLH-WD40 (MBW) complex. The MYB gene Production of Anthocyanin Pigment 1 (PAP1) plays a particularly important role in anthocyanin accumulation. PAP1 expression in many plant systems strongly increases anthocyanin levels, resulting in a dark purple color in many plant organs. In this study, we generated double mutant plants that harbor fls1ko in the pap1-D background (i.e., pap1-D/fls1ko plants), to examine whether anthocyanins can be further enhanced by blocking flavonol biosynthesis under PAP1 overexpression. We also wanted to examine whether the increased anthocyanin levels contribute to defense against osmotic stresses. The pap1-D/fls1ko mutants accumulated higher anthocyanin levels than pap1-D plants in both control and sucrose-treated conditions. However, flavonoid biosynthesis genes were slightly down-regulated in the pap1-D/fls1ko seedlings as compared to their expression in pap1-D seedlings. We also report the performance of pap1-D/fls1ko seedlings in response to plant osmotic stresses.

  16. Pap-smear Classification Using Efficient Second Order Neural Network Training Algorithms

    DEFF Research Database (Denmark)

    Ampazis, Nikolaos; Dounias, George; Jantzen, Jan

    2004-01-01

    In this paper we make use of two highly efficient second order neural network training algorithms, namely the LMAM (Levenberg-Marquardt with Adaptive Momentum) and OLMAM (Optimized Levenberg-Marquardt with Adaptive Momentum), for the construction of an efficient pap-smear test classifier. The alg......In this paper we make use of two highly efficient second order neural network training algorithms, namely the LMAM (Levenberg-Marquardt with Adaptive Momentum) and OLMAM (Optimized Levenberg-Marquardt with Adaptive Momentum), for the construction of an efficient pap-smear test classifier....... The algorithms are methodologically similar, and are based on iterations of the form employed in the Levenberg-Marquardt (LM) method for non-linear least squares problems with the inclusion of an additional adaptive momentum term arising from the formulation of the training task as a constrained optimization...

  17. [How does type of health insurance affect receipt of Pap testing in Peru?].

    Science.gov (United States)

    Barrionuevo-Rosas, Leslie; Palència, Laia; Borrell, Carme

    2013-12-01

    Describe the association between receipt of cervical cytology and type of health insurance in Peruvian women, and determine the role of sociodemographic and sexual health variables in this relationship. A cross-sectional study using information on a sample of 12 272 women aged 30 to 49 years from the Demographic and Family Health Survey (ENDES), Peru, 2005-2008. The dependent variable was receipt of at least one Pap smear in the last five years. The primary independent variables were type of health insurance, educational level, household socioeconomic level, ethnicity, and place of residence. Prevalence ratio, obtained from Poisson regression with robust variance, was used to measure multivariate association. Among sexually active women, 62.7% had received at least one Pap test in the last five years. Percentage of women tested varied by type of health insurance. Women with public or private insurance had a greater probability of having received a Pap smear--1.27 (95% CI, 1.24-1.31) and 1.52 (95% CI, 1.46-1.58) times greater, respectively--than uninsured women. This association was primarily explained by socioeconomic status variables. In addition, women who participated the least in screening were characterized by illiteracy or only a primary education, low socioeconomic level, speaking an indigenous language, and living in a rural area. When they also lacked health insurance, the gap widened, rising to as much as one third compared to more advantaged social groups. Inequalities were found in receipt of Pap testing according to type of health insurance; women without insurance were least likely to be screened, implying existence of a barrier to cervical cancer screening in Peru.

  18. ThinPrep Pap-smear and cervical intraepithelial neoplasia in reproductive-aged Thai women.

    Science.gov (United States)

    Rugpao, S; Koonlertkit, S; Ruengkrist, T; Lamlertkittikul, S; Pinjaroen, S; Limtrakul, A; Werawatakul, Y; Sinchai, W

    2009-06-01

    To estimate the incidence of abnormal cervical cytology by ThinPrep Pap-tests and cervical intraepithelial neoplasia (CIN) in young adult reproductive-aged Thai women. A total of 1254 women distributed in all regions of Thailand were monitored from 2002 through 2004. Women were screened for abnormal cervical cytology using the ThinPrep method every 6 months. Interpretation of cervical cytology was based on the Bethesda system, version 2001. Women who had the ThinPrep Pap results as atypical squamous cells of undetermined significance or worse underwent colposcopic examination. The ThinPrep and all cervical tissue samples obtained from diagnostic or therapeutic procedures were analyzed and reviewed by Covance Central Laboratory Service, Inc., Indianapolis, USA. The cumulative incidence of abnormal ThinPrep Pap-tests was as follows: 15.3 per 100 woman years (WY) (95% confidence interval [CI] 12.3, 18.9) at 6 months; 12.3 per 100 WY (95% CI 10.3, 14.6) at 12 months; and 11.6 per 100 WY (95% CI 10.0, 13.5) at 18 months. Of 1448.6 woman years of follow up, the incidence of CIN1 was 4.1 per 100 WY (95% CI 3.2, 5.3); CIN2 0.8 per 100 WY (95% CI 0.4, 1.4); and CIN3 0.6 per 100 WY (95% CI 0.3, 1.2). The incidence of abnormal ThinPrep Pap-test and CIN in young adult Thai women had been reported. No comparable data is available.

  19. Knowledge, Attitudes and Practices of Sudanese Women Regarding the Pap Smear Test and Cervical Cancer.

    Science.gov (United States)

    Almobarak, Ahmed O; Elbadawi, Ayman A; Elmadhoun, Wadie M; Elhoweris, Mohammed H; Ahmed, Mohammed H

    2016-01-01

    Despite the established role of the Pap smear test (PST) in prevention and early detection of cervical cancer, it is still rarely practiced in Sudan. Many challenges hinder the establishment of an effective cervical cancer screening program, including socio-cultural factors. Therefore, this study aimed to investigate the knowledge, attitudes and practices (KAP) of Sudanese women with regard to the Pap smear test and cervical cancer. A total of 500 married women aged 14 to 58 years were recruited from obstetric clinics, hospitals and universities in Khartoum in 2014. Data were collected using a standardized, pretested questionnaire that inquired socio-demographic characteristics and their KAP about cervical cancer and the PST. More than 52% of participating women were above 30 years of age, and the majority (78.8%) were university degree holders. A total of 486 (97.2 %) of participants were resident in urban areas of Khartoum State. However about 48% of the respondents had never heard about PST, and only 15.8% of the participants had undergone a Pap smear test previously; 46.6% (233/500) knew that the human papilloma virus (HPV) was the causative agent, but only 39.2% (196/500) had heard about HPV vaccination, and only 11.4% (57/500) had received the vaccine. However 68% of the respondents agreed to do Pap smear if properly informed about the test and 75.4% of the respondents agreed to participate in a cervical cancer screening program. Despite a high educational level, less than half of our participants had accurate knowledge about cervical cancer, HPV, and cervical cancer screening. Health education about cervical cancer, HPV and sexually transmitted infections and the role of PST in cervical cancer prevention are crucial when designing interventions aimed at improving cervical cancer screening for Sudanese women.

  20. Production of thermostable invertases by Aspergillus caespitosus under submerged or solid state fermentation using agroindustrial residues as carbon source Produção de invertases termoestáveis por Aspergillus caespitosus em fermentação submersa e em estado sólido usando resíduos agroindustriais como fonte de carbono

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Paiva Alegre

    2009-09-01

    Full Text Available The filamentous fungus Aspergillus caespitosus was a good producer of intracellular and extracellular invertases under submerged (SbmF or solid-state fermentation (SSF, using agroindustrial residues, such as wheat bran, as carbon source. The production of extracellular enzyme under SSF at 30ºC, for 72h, was enhanced using SR salt solution (1:1, w/v to humidify the substrate. The extracellular activity under SSF using wheat bran was around 5.5-fold higher than that obtained in SbmF (Khanna medium with the same carbon source. However, the production of enzyme with wheat bran plus oat meal was 2.2-fold higher than wheat bran isolated. The enzymatic production was affected by supplementation with nitrogen and phosphate sources. The addition of glucose in SbmF and SSF promoted the decreasing of extracellular activity, but the intracellular form obtained in SbmF was enhanced 3-5-fold. The invertase produced in SSF exhibited optimum temperature at 50ºC while the extraand intracellular enzymes produced in SbmF exhibited maximal activities at 60ºC. All enzymatic forms exhibited maximal activities at pH 4.0-6.0 and were stable up to 1 hour at 50ºC.O fungo filamentoso Aspergillus caespitosus foi um bom produtor de invertases intracelular e extracelular em fermentação submersa (FSbm ou em estado sólido (FES, usando resíduos agroindustriais como fonte de carbono, sendo que para ambas as condições de cultivo, a maior produtividade foi obtida empregandose farelo de trigo. A produção da forma extracelular em FES mantido a 30ºC, por 72 horas, foi aumentada usandose solução de sais SR (1:1, m/v para umidificar o substrato, sendo aproximadamente 5,5 vezes maior se comparada a FSbm (Meio Khanna com a mesma fonte de carbono. Entretanto, a mistura de farelo de trigo e farinha de aveia em FES levou a um aumento de 2,2 vezes na produção enzimática se comparada ao uso isolado do farelo de trigo. A produção enzimática, em ambas as condições de

  1. Electronic and optoelectronic device applications based on ReS2

    Science.gov (United States)

    Liu, Erfu; Long, Mingsheng; Wang, Yaojia; Pan, Yiming; Ho, Chinghwa; Wang, Baigeng; Miao, Feng

    Rhenium disulfide (ReS2) is a unique semiconducting TMD with distorted 1T structure and weak interlayer coupling. We have previously investigated its in-plane anisotropic property and electronic applications on FET and digital inverters. In this talk, we will present high responsivity phototransistors based on few-layer ReS2. Depending on the back gate voltage, source drain bias and incident optical light intensity, the maximum attainable photoresponsivity can reach as high as 88,600 A W-1, which is one of the highest value among individual two-dimensional materials with similar device structures. Such high photoresponsivity is attributed to the increased light absorption as well as the gain enhancement due to the existence of trap states in the few-layer ReS2 flakes. The existence of trap states is proved by temperature dependent transport measurements. It further enables the detection of weak signals. Our studies underscore ReS2 as a promising material for future electronic and sensitive optoelectronic applications.

  2. Distribution of costs induced by the integration of RES-E power

    International Nuclear Information System (INIS)

    Barth, Ruediger; Weber, Christoph; Swider, Derk J.

    2008-01-01

    This article focuses on the distribution of costs induced by the integration of electricity generation from renewable energy sources (RES-E). The treatment to distribute these costs on different market actors is crucial for its development. For this purpose, individual actors of electricity markets and several cost categories are identified. According to the defined cost structure, possible treatments to distribute the individual cost categories on different relevant actors are described. Finally, an evaluation of the cost distribution treatments based on an economic analysis is given. Economic efficiency recommends that clearly attributable (shallow) grid connection as well as (deep) grid costs are charged to the corresponding RES-E producer and that the RES-E producers are also charged the regulating power costs. However, deep grid integration costs should be updated to reflect evolving scarcities. Also regulating power costs should reflect actual scarcity and thus be symmetric and based on real-time prices, taking into account the overall system imbalance. Moreover, the time span between the closure of the spot market and actual delivery should be chosen as short as possible to enable accurate RES-E production forecasts

  3. Abnormal pap tests among women living in a Hispanic migrant farmworker community: A narrative of health literacy.

    Science.gov (United States)

    Vamos, Cheryl A; Lockhart, Elizabeth; Vázquez-Otero, Coralia; Thompson, Erika L; Proctor, Sara; Wells, Kristen J; Daley, Ellen M

    2016-08-01

    This study explored narrative responses following abnormal Pap tests among Hispanic migrant farmworkers ( N = 18; ages 22-50 years) via in-depth interviews in Florida. Qualitative analyses utilized health literacy domains (obtain/process/understand/communicate) as a conceptual framework. Participants described how they (1) obtained information about getting a Pap test, (2) processed positive and negative reactions following results, (3) understood results and recommended health-promoting behaviors, and (4) communicated and received social support. Women had disparate reactions and understanding following an abnormal Pap result. Health literacy was a meaningful conceptual framework to understand assets and gaps among women receiving an abnormal Pap test result. Future interventions should incorporate health literacy domains and facilitate patient-provider communications and social support to assist women in decision-making and health-promoting behaviors, ultimately decreasing cancer disparities.

  4. Honouring Stories: Mi'kmaq Women's Experiences with Pap Screening in Eastern Canada.

    Science.gov (United States)

    MacDonald, Catherine; Martin-Misener, Ruth; Steenbeek, Audrey; Browne, Annette

    2015-03-01

    Mi'kmaq women are reported to have lower rates of Papanicolaou (Pap) screening and higher rates of cervical cancer than non-Aboriginal women. This qualitative participatory study used postcolonial feminist perspectives and Indigenous principles to explore Mi'kmaq women's experiences with Pap screening within the contexts that shaped their experiences. Community facilitators assisted with the research process. Talking circles and individual in-depth interviews were conducted with 16 Mi'kmaq women. Also, health-care providers were interviewed in 2 Mi'kmaq communities. The findings indicate that historical and social contexts are shaping Mi'kmaq women's screening experiences and that these experiences are diverse, as are their understandings about screening. Some women were accessing regular screening despite challenging personal circumstances. The results highlight the need for nurses and other health-care providers to understand the uniqueness of each woman's experiences with Pap screening. Improvements in screening rates depend on multifaceted nursing approaches developed in partnership with Mi'kmaq women. Copyright© by Ingram School of Nursing, McGill University.

  5. How group education impacts female factory workers' behavior and readiness to receive mammography and Pap smear.

    Science.gov (United States)

    Seven, Memnun; Bahar, Mine; Akyüz, Aygül; Erdoğan, Hatice

    2015-01-01

    The workplace has been deemed a suitable location for educating many women at once about cancer screening. To determine how group education about early diagnostic methods for breast and cervical cancer effects women's behavior and readiness to receive mammography and Pap smear. This semi-interventional study was conducted at a textile factory in Istanbul, Turkey. Female workers (n= 125) were included in the study. A participant identification form and knowledge evaluation form developed for this study, along with the transtheoretical model, were used to collect data. A 45-min interactive group education was given to the participants. Upon contacting participants 3 months after group education, 15.4% (n = 11) stated that they had since received a mammogram and 9.8% (n = 7) a Pap smear. As suggested by the transtheoretical model, group education increased participants' readiness to receive cancer screening, along with their knowledge of breast and cervical cancer. Group education positively impacted women's knowledge of cancer and their readiness to receive mammography and Pap smear. Group education can potentially create awareness of cancer screening tests among women and improve their readiness to receive such tests.

  6. Res Publica Euroopas / Eiki Berg, Marko Mihkelson ; interv. Lauri Lugna

    Index Scriptorium Estoniae

    Berg, Eiki, 1970-

    2003-01-01

    Res Publica välispoliitika eksperdid Eiki Berg ja Marko Mihkelson vastavad küsimustele, mis käsitlevad Res Publica saamist Euroopa Rahvapartei (ERP) liikmeks, koostööd ERP-ga, EL-i põhiseaduslikku lepet

  7. Res Publica viskab Oleg Rebase välja

    Index Scriptorium Estoniae

    2006-01-01

    Res Publica Tallinna piirkonna juhatus leidis, et Oleg Rebane läks Keskerakonna provokatsiooniga kaasa minnes vastuollu Res Publica põhimõtetega. Tallinna linnapea Jüri Ratase suhtes algatatud umbusaldushääletuse põhjustest. Sven Sester vastab küsimusele, mis seotud Oleg Rebase ja Tõnis Bittmani juhtumiga

  8. Intelligent energy buildings based on RES and nanotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Kaplanis, S., E-mail: kaplanis@teipat.gr; Kaplani, E. [R.E.S. Laboratory, Mechanical Engineering Dept., Technological Educational Institute of Western Greece M. Alexandrou 1, Koukouli 26 334, Patra (Greece)

    2015-12-31

    The paper presents the design features, the energy modelling and optical performance details of two pilot Intelligent Energy Buildings, (IEB). Both are evolution of the Zero Energy Building (ZEB) concept. RES innovations backed up by signal processing, simulation models and ICT tools were embedded into the building structures in order to implement a new predictive energy management concept. In addition, nano-coatings, produced by TiO2 and ITO nano-particles, were deposited on the IEB structural elements and especially on the window panes and the PV glass covers. They exhibited promising SSP values which lowered the cooling loads and increased the PV modules yield. Both pilot IEB units were equipped with an on-line dynamic hourly solar radiation prediction model, implemented by sensors and the related software to manage effectively the energy source, the loads and the storage or the backup system. The IEB energy sources covered the thermal loads via a south façade embedded in the wall and a solar roof which consists of a specially designed solar collector type, while a PV generator is part of the solar roof, like a compact BIPV in hybrid configuration to a small wind turbine.

  9. Power utility generation portfolio optimization as function of specific RES and decarbonisation targets – EPBiH case study

    International Nuclear Information System (INIS)

    Kazagic, Anes; Merzic, Ajla; Redzic, Elma; Music, Mustafa

    2014-01-01

    Highlights: • Guidelines for power utilities to reach specific decarbonisation targets offered. • Optimization model of RES share to be introduced into power system is proposed. • Single criteria analysis and multicriteria sustainability assessment are applied. • The optimization method has been demonstrated on a real power system. • In the considered case, HIGH RES scenario showed to be the preferable one. - Abstract: This paper provides guidelines and principles for power utilities to reach specific energy and decarbonisation targets. Method of power generation portfolio optimization, as function of sustainability and decarbonisation, along with appropriate criteria, has been proposed. Application of this optimization method has been demonstrated on a real power system – power utility JP Elektroprivreda BiH d.d. – Sarajevo (EPBiH), a typical example of South East European power system. The software tool WASP IV has been employed in the analysis, in order to define the dynamics and an optimized expansion of generation portfolio of the power system under consideration for the next period. The mid-term generation portfolio development plan for the EPBiH power system until year 2030 has been made during this research, taking into account the shutdown dynamics of existing power units and commissioning new ones, in order to provide safe supply of electric and heat energy for local consumers. Three basic scenario of renewable energy sources (RES) expansion have been analysed to reach specific RES and decarbonisation targets set for 2030, including RES share increase from the current level of 18% up to 35% (LOW RES), 45% (MID RES) and 55% (HIGH RES). Effects to the sustainability are considered through environmental, economic and social indicators. Multicriteria sustainability assessment gave an advantage to the HIGH RES, under assumption of equal weighting factors of economic and environment groups of indicators. Also, single criteria analysis has been

  10. Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine.

    Science.gov (United States)

    Volkan, Ender; Ford, Bradley A; Pinkner, Jerome S; Dodson, Karen W; Henderson, Nadine S; Thanassi, David G; Waksman, Gabriel; Hultgren, Scott J

    2012-06-12

    P pili are prototypical chaperone-usher pathway-assembled pili used by Gram-negative bacteria to adhere to host tissues. The PapC usher contains five functional domains: a transmembrane β-barrel, a β-sandwich Plug, an N-terminal (periplasmic) domain (NTD), and two C-terminal (periplasmic) domains, CTD1 and CTD2. Here, we delineated usher domain interactions between themselves and with chaperone-subunit complexes and showed that overexpression of individual usher domains inhibits pilus assembly. Prior work revealed that the Plug domain occludes the pore of the transmembrane domain of a solitary usher, but the chaperone-adhesin-bound usher has its Plug displaced from the pore, adjacent to the NTD. We demonstrate an interaction between the NTD and Plug domains that suggests a biophysical basis for usher gating. Furthermore, we found that the NTD exhibits high-affinity binding to the chaperone-adhesin (PapDG) complex and low-affinity binding to the major tip subunit PapE (PapDE). We also demonstrate that CTD2 binds with lower affinity to all tested chaperone-subunit complexes except for the chaperone-terminator subunit (PapDH) and has a catalytic role in dissociating the NTD-PapDG complex, suggesting an interplay between recruitment to the NTD and transfer to CTD2 during pilus initiation. The Plug domain and the NTD-Plug complex bound all of the chaperone-subunit complexes tested including PapDH, suggesting that the Plug actively recruits chaperone-subunit complexes to the usher and is the sole recruiter of PapDH. Overall, our studies reveal the cooperative, active roles played by periplasmic domains of the usher to initiate, grow, and terminate a prototypical chaperone-usher pathway pilus.

  11. Gestão de resíduos sólidos em restaurante escola

    Directory of Open Access Journals (Sweden)

    Bianca Peruchin

    2013-01-01

    Full Text Available Um dos maiores problemas ambientais da atualidade é a excessiva geração de resíduos e a sua destinação final ambientalmente adequada. As Instituições de Ensino Superior (IES são importantes fontes geradoras devido à diversidade de atividades de ensino, pesquisa e extensão realizadas no seu âmbito. Os Restaurantes Escola (RE atendem à comunidade acadêmica dos campi universitários, e caracterizam-se por produzir resíduos similares aos domésticos, mas em maior quantidade. Este estudo foi realizado com o objetivo de investigar a composição gravimétrica dos resíduos produzidos em um RE de uma IES localizada no sul do país, bem como conhecer a situação atual do gerenciamento dos resíduos. Os dados foram obtidos através da caracterização dos resíduos do RE durante cinco dias, de entrevista com os gestores responsáveis pelo estabelecimento e da observação direta no local. Averiguou-se a inexistência de um Plano de Gerenciamento dos Resíduos Sólidos no RE, bem como a ausência de práticas efetivas relacionadas ao manejo destes. A segregação dos resíduos é prejudicada devido à falta de lixeiras específicas e a sobrecarga dos funcionários quanto às atividades desempenhadas. Ao longo do período experimental foram caracterizados 547,068 Kg de resíduos, dos quais mais de 80% corresponderam à matéria orgânica. Conclui-se que o montante de resíduo orgânico gerado pode ser destinado à compostagem. Recomenda-se a implantação de uma infraestrutura adequada para o manejo dos resíduos, que pode ser feita através da elaboração e aplicação de um plano de gestão integrada dos resíduos sólidos no RE.Abstract Nowadays, the amount of waste generated and its proper final destination is one of the greatest environmental issues. Higher education institutions are an important source of waste due to the diversity of teaching, researching and extension activities performed in their facilities. The university

  12. Cervical cancer screening attitudes and beliefs of Malaysian women who have never had a pap smear: a qualitative study.

    Science.gov (United States)

    Wong, L P; Wong, Y L; Low, W Y; Khoo, E M; Shuib, R

    2008-01-01

    Attitudes toward cervical cancer and participation in early detection and screening services are well known to be profoundly affected by cultural beliefs and norms. This study explored the attitudes and sociocultural beliefs on cervical cancer screening among Malaysian women. In this qualitative study, in-depth interviews were conducted with 20 Malaysian women, ages 21 to 56 years, who have never had a Papanicolaou (Pap) smear. Respondents generally showed a lack of knowledge about cervical cancer screening using Pap smear, and the need for early detection for cervical cancer. Many believed the Pap smear was a diagnostic test for cervical cancer, and since they had no symptoms, they did not go for Pap screening. Other main reasons for not doing the screening included lack of awareness of Pap smear indications and benefits, perceived low susceptibility to cervical cancer, and embarrassment. Other reasons for not being screened were related to fear of pain, misconceptions about cervical cancer, fatalistic attitude, and undervaluation of own health needs versus those of the family. Women need to be educated about the benefits of cervical cancer screening. Health education, counseling, outreach programs, and community-based interventions are needed to improve the uptake of Pap smear in Malaysia.

  13. Evaluation and significance of hyperchromatic crowded groups (HCG in liquid-based paps

    Directory of Open Access Journals (Sweden)

    Chivukula Mamatha

    2007-01-01

    Full Text Available Abstract Objective Hyperchromatic crowded groups (HCG, a term first introduced into the cytology literature by DeMay in 1995, are commonly observed in Pap tests and may rarely be associated with serious but difficult to interpret lesions. In this study, we specifically defined HCG as dark crowded cell groups with more than 15 cells which can be identified at 10× screening magnification. Methods We evaluated consecutive liquid-based (Surepath Pap tests from 601 women (age 17–74 years, mean age 29.4 yrs and observed HCG in 477 cases. In all 477 HCG cases, Pap tests were found to be satisfactory and to contain an endocervical sample. HCG were easily detectible at 10× screening magnification (size up to 400 um, mean 239.5 um and ranged from 1 to 50 (mean 19.5 per Pap slide. Results HCG predominantly represented 3-Dimensional groups of endocervical cells with some nuclear overlap (379/477 – 79%, reactive endocervical cells with relatively prominent nucleoli and some nuclear crowding (29/477 – 6%, clusters of inflammatory cells (25/477 – 5.2%, parabasal cells (22/477 – 4.6%, endometrial cells (1/477 – 0.2%. Epithelial cell abnormalities (ECA were present in only 21 of 477 cases (4.6%. 18 of 21 women with HCG-associated ECA were less than 40 years old; only 3 were =/> 40 years. HCG-associated final abnormal Pap test interpretations were as follows: ASCUS (6/21 – 28%, LSIL (12/21 – 57%, ASC-H (2/21 – 9.5%, and HSIL/CIN2-3 (3/21 – 14%. The association of HCG with ECA was statistically significant (p = 0.0174. chi-square test. In patients with ECA, biopsy results were available in 10 cases, and 4 cases of biopsy-proven CIN2/3 were detected. Among these four cases, HCG in the Pap tests, in retrospect represented the lesional high grade cells in three cases (one HSIL case and two ASC-H cases. Interestingly, none of the 124 cases without HCG were found to have an epithelial cell abnormality. Conclusion We conclude: a. HCG are observed

  14. The Prevalence of Abnormal Pap Smears in females Referred to Health Centers Affiliated to Medical Sciences During the Years 2012 to 2016

    Directory of Open Access Journals (Sweden)

    Zahra Massomi

    2016-06-01

    Full Text Available Background and Objectives: Cervical cancer is one of the most important female reproductive system diseases. The aim of this study was to estimate the prevalence of abnormal Pap smears of pregnant females in public health centers and hospitals of Hamadan. Materials and Methods: In a retrospective study, 36046 Pap smears of females was extracted from the records referred to government health centers affiliated to Hamadan University of Medical Sciences and Fatemiyeh Hospital Hamadan, between 2012 and 2016. After checking the results of Pap smear, abnormal information (605 cases were collected and investigated. Data were then analyzed using the SPSS21-software and descriptive statistics and one-way Analysis of Variance (ANOVA. Results: The majority of females with abnormal Pap smear results (%30.4 were aged 45 to 36 years, and %48.6 of females with abnormal Pap smear had parity (1-3. From a total of 36046 cases, 605 cases of abnormal Pap smear were observed. The highest and lowest frequencies of abnormal Pap smear were related to ASCUS and LSIL, at a prevalence of %78 and %1, respectively. There was a positive relationship between abnormal Pap smear results and age (P = 0.037. Conclusions: The prevalence of abnormal Pap smear in Hamadan was %1.67. Malignant cervical cancer and invasive cancer risk increased with age, hence, screening and Pap smear, especially from age 35 and above, is recommended.

  15. Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A Polymerases in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Christian Kappel

    2015-08-01

    Full Text Available The poly(A tail at 3' ends of eukaryotic mRNAs promotes their nuclear export, stability and translational efficiency, and changes in its length can strongly impact gene expression. The Arabidopsis thaliana genome encodes three canonical nuclear poly(A polymerases, PAPS1, PAPS2 and PAPS4. As shown by their different mutant phenotypes, these three isoforms are functionally specialized, with PAPS1 modifying organ growth and suppressing a constitutive immune response. However, the molecular basis of this specialization is largely unknown. Here, we have estimated poly(A-tail lengths on a transcriptome-wide scale in wild-type and paps1 mutants. This identified categories of genes as particularly strongly affected in paps1 mutants, including genes encoding ribosomal proteins, cell-division factors and major carbohydrate-metabolic proteins. We experimentally verified two novel functions of PAPS1 in ribosome biogenesis and redox homoeostasis that were predicted based on the analysis of poly(A-tail length changes in paps1 mutants. When overlaying the PAPS1-dependent effects observed here with coexpression analysis based on independent microarray data, the two clusters of transcripts that are most closely coexpressed with PAPS1 show the strongest change in poly(A-tail length and transcript abundance in paps1 mutants in our analysis. This suggests that their coexpression reflects at least partly the preferential polyadenylation of these transcripts by PAPS1 versus the other two poly(A-polymerase isoforms. Thus, transcriptome-wide analysis of poly(A-tail lengths identifies novel biological functions and likely target transcripts for polyadenylation by PAPS1. Data integration with large-scale co-expression data suggests that changes in the relative activities of the isoforms are used as an endogenous mechanism to co-ordinately modulate plant gene expression.

  16. Res Publica lükkas tagasi Isamaaliidu ühinemisettepaneku / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2005-01-01

    Kuigi Res Publica juhid lükkasid tagasi idee ühineda Isamaaliiduga, on Res Publica valmis koostööks nii Isamaaliidu kui ka kõigi teiste erakondadega. Res Publica parlamendifraktsiooni esimehe Marko Pomerantsi arvamus

  17. ResStock - Targeting Energy and Cost Savings for U.S. Homes

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Eric J [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-29

    The ResStock analysis tool is helping states, municipalities, utilities, and manufacturers identify which home upgrades save the most energy and money. Across the country there's a vast diversity in the age, size, construction practices, installed equipment, appliances, and resident behavior of the housing stock, not to mention the range of climates. These variations have hindered the accuracy of predicting savings for existing homes. Researchers at the National Renewable Energy Laboratory (NREL) developed ResStock. It's a versatile tool that takes a new approach to large-scale residential energy analysis by combining: large public and private data sources, statistical sampling, detailed subhourly building simulations, high-performance computing. This combination achieves unprecedented granularity and most importantly - accuracy - in modeling the diversity of the single-family housing stock.

  18. Isamaa ja Res Publica Liidu plaan / Juhan Parts

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2008-01-01

    Ilmunud ka: Eesti Eest = Za Estoniju : Izdanije objedinenija "Sojuz Otetshestva i Res Publica" 15. mai 2008, lk. 4-5. Eesti majanduse uutest ülesannetest. Kommenteerib: Mart Laar. Vt. samas: IRL-i ettepanekud koalitsioonileppe täienduseks

  19. Bacterial vaginosis, aerobic vaginitis, vaginal inflammation and major Pap smear abnormalities.

    Science.gov (United States)

    Vieira-Baptista, P; Lima-Silva, J; Pinto, C; Saldanha, C; Beires, J; Martinez-de-Oliveira, J; Donders, G

    2016-04-01

    The purpose of this investigation was to evaluate the impact of the vaginal milieu on the presence of abnormal Pap smears and a positive human papilloma virus (HPV) test. A cross-sectional study was conducted between June 2014 and May 2015, evaluating the vaginal discharge by fresh wet mount microscopy and comparing these data with Pap smear findings. Wet mount slides were scored for bacterial vaginosis (BV), aerobic vaginitis (AV), presence of Candida and Trichomonas vaginalis. Cytologic evaluation was done on all Pap smears according to the Bethesda criteria. The cobas© HPV Test (Roche) was performed for HPV detection. A total of 622 cases were evaluated. The mean age of the patients was 41.6 ± 10.65 years (range 21-75). Eighty-three women (13.3 %) had a cytology result worse than low-grade squamous intraepithelial lesion (LSIL). When comparing this group with the one with normal or minor [atypical squamous cells of undetermined significance (ASC-US) or LSIL] Pap smear abnormalities, there were no differences in the presence of Candida (32.5 % vs. 33.2 %, p = 1.0), absence of lactobacilli (38.6 % vs. 32.5 %, p = 0.32) or BV (20.5 % vs. 13.2 %, p = 0.09). On the other hand, moderate or severe inflammation (msI) (41.0 % vs. 28.8 %, p = 0,04), moderate or severe AV (msAV) (16.9 % vs. 7.2 %, p = 0.009) and msAV/BV (37.3 % vs. 20.0 %, p = 0.001) were more common in women with such major cervical abnormalities. No significant association was found between deviations of the vaginal milieu and high-risk HPV infection. The presence of msI or msAV, but not BV, is independently associated with an increased risk of major cervical cytological abnormalities, but not with HPV infection.

  20. Interactive surface in the PapD chaperone cleft is conserved in pilus chaperone superfamily and essential in subunit recognition and assembly.

    OpenAIRE

    Slonim, L N; Pinkner, J S; Brändén, C I; Hultgren, S J

    1992-01-01

    The assembly of adhesive pili in Gram-negative bacteria is modulated by specialized periplasmic chaperone systems. PapD is the prototype member of the superfamily of periplasmic pilus chaperones. Previously, the alignment of chaperone sequences superimposed on the three dimensional structure of PapD revealed the presence of invariant, conserved and variable amino acids. Representative residues that protruded into the PapD cleft were targeted for site directed mutagenesis to investigate the pi...

  1. Oil Companies and Reserves | Compagnies et réserves pétrolières

    Directory of Open Access Journals (Sweden)

    2012-05-01

    Full Text Available Top 20 World Oil CorporationsTop 20 des compagnies pétrolières mondialesSources: OPEC, Annual Statistical Bulletin, 2009; 2009 official reports of oil companies; British Petroleum, BP Statistical Review of Word Energy, 2010.Crude Oil Exports per Area (in Million Tonnes, 2009Exportations de pétrole brut par région (en millions de tonnes, 2009Sources : www.iea.org; www.opec.org; www.gecforum.org; British Petroleum, BP Statistical Review of World Energy, 2010.China’s Crude Oil Imports from Afr...

  2. Comment rendre les villes plus sûres

    International Development Research Centre (IDRC) Digital Library (Canada)

    qui travaillent à l'initiative Villes sûres et inclusives font la lumière sur ce qui fonctionne – et ne fonctionne pas – pour rendre les villes plus sûres. Le présent compte rendu comporte certains enseignements tirés de leur travail, ainsi que les lacunes dans les connaissances et les domaines où il faut poursuivre la recherche.

  3. Identification of Biomarkers of Exposure to FTOHs and PAPs in Humans Using a Targeted and Nontargeted Analysis Approach.

    Science.gov (United States)

    Dagnino, Sonia; Strynar, Mark J; McMahen, Rebecca L; Lau, Christopher S; Ball, Carol; Garantziotis, Stavros; Webster, Thomas F; McClean, Michael D; Lindstrom, Andrew B

    2016-09-20

    Although historic perfluorinated compounds are currently under scrutiny and growing regulatory control in the world, little is known about human exposure to other polyfluorinated compounds presently in use. Fluorotelomer alcohols (FTOHs) and polyfluoroalkyl phosphate esters (PAPs) are known to degrade to terminal perfluorinated acids and toxic reactive intermediates through metabolic pathways. Therefore, it is important to characterize their human exposure by the identification of unique biomarkers. With the use of liquid chromatography-mass spectrometry-time-of-flight analysis (LC-MS-TOF), we developed a workflow for the identification of metabolites for the 8:2 FTOH and 8:2 diPAP. Analysis of serum and urine of dosed rats indicated the 8:2 FTOH-sulfate and the 8:2 diPAP as potential biomarkers. These compounds, as well as 25 other fluorinated compounds and metabolites, were analyzed in human serum and urine samples from the general population (n = 100) and office workers (n = 30). The 8:2 FTOH-sulfate was measured for the first time in human samples in 5 to 10% of the serum samples, ranging from 50 to 80 pg/mL. The 8:2 diPAP was measured in 58% of the samples, ranging from 100 to 800 pg/mL. This study indicates the FTOH-sulfate conjugate as a biomarker of exposure to FTOHs and PAPs in humans.

  4. Large-Area CVD-Grown Sub-2 V ReS2 Transistors and Logic Gates.

    Science.gov (United States)

    Dathbun, Ajjiporn; Kim, Youngchan; Kim, Seongchan; Yoo, Youngjae; Kang, Moon Sung; Lee, Changgu; Cho, Jeong Ho

    2017-05-10

    We demonstrated the fabrication of large-area ReS 2 transistors and logic gates composed of a chemical vapor deposition (CVD)-grown multilayer ReS 2 semiconductor channel and graphene electrodes. Single-layer graphene was used as the source/drain and coplanar gate electrodes. An ion gel with an ultrahigh capacitance effectively gated the ReS 2 channel at a low voltage, below 2 V, through a coplanar gate. The contact resistance of the ion gel-gated ReS 2 transistors with graphene electrodes decreased dramatically compared with the SiO 2 -devices prepared with Cr electrodes. The resulting transistors exhibited good device performances, including a maximum electron mobility of 0.9 cm 2 /(V s) and an on/off current ratio exceeding 10 4 . NMOS logic devices, such as NOT, NAND, and NOR gates, were assembled using the resulting transistors as a proof of concept demonstration of the applicability of the devices to complex logic circuits. The large-area synthesis of ReS 2 semiconductors and graphene electrodes and their applications in logic devices open up new opportunities for realizing future flexible electronics based on 2D nanomaterials.

  5. OTTO-PAP: An alternative option to the PBMR fuelling philosophy

    International Nuclear Information System (INIS)

    Mulder, E.; Teuchert, E.

    1997-01-01

    Once Through Then Out, Power Adjusted by Poison (OTTO-PAP) fuelling of a high temperature pebble-bed reactor offers a simple alternative to the MEDUL (Mehrfachdurchlauf = German for multi-pass) fuelling regime followed in pebble bed reactor designs to date. The prerequisite for a modular reactor unit of maximum power output, subject to observing passive safety characteristics is a sufficiently flat axial neutron flux profile. This is achieved by introducing B 4 C coated particles of pre-calculated size and packing density within the fuel spheres. In accordance with AVR operating practise the temperature profile is radially equalised by introducing a 2-zone core loading. Adding pure graphite spheres loosely into the centre column area of the core effectively reduced the maximum power in the middle. Increasing the reactor diameter is enabled by the introduction of noses. A 3-D geometric modeller developed in cylindrical co-ordinates enables a given flow description of the pebbles adjacent to the nose boundaries and in the vicinity of the shut down/control rods. After translation of the geometric data the neutronic behaviour of the reactor is followed in 3-D by the CITATION code. This study is aimed towards achieving an optimal core layout with a LEU (Low Enriched Uranium) fuel cycle. Physical properties of the OTTO-PAP, 150 MWt reference design is reported, while computations performed observe results obtained by the reference HTR-MODUL design. (author)

  6. Vaginal flora changes on Pap smears after insertion of levonorgestrel-releasing intrauterine device.

    Science.gov (United States)

    Donders, Gilbert G G; Berger, Judith; Heuninckx, Hélène; Bellen, Gert; Cornelis, Ann

    2011-04-01

    The levonorgestrel intrauterine system (LNG-IUS) combines a uterine foreign body and the continuous release of low-dose levonorgestrel for contraception. Its influence on the rate of vulvovaginal infections and flora disturbance is insufficiently known, but important for contraceptive advice in women, especially those who develop recurrent vaginosis or Candida vulvovaginitis. Slides of 286 women who had a Pap smear taken before and 1 to 2 years after placement of a LNG-IUS were blindly reviewed for the presence of abnormal vaginal flora (AVF), bacterial vaginosis (BV), aerobic vaginitis (AV) and Candida vaginitis (CV). Prior to insertion, there were no differences in vaginal flora abnormalities between women using different kinds of contraception. LNG-IUS users did not have different rates of AVF, BV, AV or CV, but the general risk to develop any infection was increased. Uterine bleeding after insertion did not seem to predict a different flora type. We found that Pap smears suggested more vaginal infections after 1 year of LNG-IUS use than prior to insertion of the device. Copyright © 2011 Elsevier Inc. All rights reserved.

  7. TOURISM AS A PATHWAY FOR RES UTILISATION

    OpenAIRE

    Kulisic, Biljana; Zidar, Margareta; Jelavic, Branka; Domac, Julije; Segon, Velimir

    2008-01-01

    Tourism, due its property of being an “invisible export” sector, has a strong multiplier effect over the economy. Tourists boost demand for numerous goods and services, one of them being energy. Unfortunately, energy sources are scarce for most of the countries in the region. Thus, one could think of another solution to the excess demand for energy than import. Namely, for more than a decade, renewable energy sources are in the central focus of the EU energy policy with an aim to ensure se...

  8. Increasing Pap smear rates at an urban Aboriginal Community Controlled Health Service through translational research and continuous quality improvement.

    Science.gov (United States)

    Dorrington, Melanie S; Herceg, Ana; Douglas, Kirsty; Tongs, Julie; Bookallil, Marianne

    2015-01-01

    This article describes translational research (TR) and continuous quality improvement (CQI) processes used to identify and address barriers and facilitators to Pap smear screening within an urban Aboriginal Community Controlled Health Service (ACCHS). Rapid Plan-Do-Study-Act (PDSA) cycles were conducted, informed by client surveys, a data collection tool, focus groups and internal research. There was a statistically significant increase in Pap smear numbers during PDSA cycles, continuing at 10 months follow up. The use of TR with CQI appears to be an effective and acceptable way to affect Pap smear screening. Community and service collaboration should be at the core of research in Aboriginal and Torres Strait Islander health settings. This model is transferrable to other settings and other health issues.

  9. Application of the Perceptual Factors, Enabling and Reinforcing Model on Pap Smaear Screening in Iranian Northern Woman

    Directory of Open Access Journals (Sweden)

    Abolhassan Naghibi

    2016-03-01

    Full Text Available Background and Purpose: Cervical cancer is the most prevalent cancer among women in the world. Cervical cancer is no symptoms and can be treated if diagnosed in the first stage of the disease. The aim of this study was to survey the affecting factors of the Pap smears test on perceptual factors, enabling and reinforcing (PEN-3 model constructs in women. Materials and Methods: This study was a descriptive cross-sectional study. The sample size was 416 married women with random sampling. The questionnaire had 50 questions based on PEN-3 model structures. Data were analyzed by descriptive statistics and logistic regression method in software SPSS 20. Results: The mean age of women was 32.70 ± 21.00 years. The knowledge of risk factors and screening methods for cervical cancer was 37.2. About 40% of women had a history of Pap smears. The most important of perception factors were effective, family history of the disease, encourage people to Pap smear, and fear of detecting of cervical cancer. The most important enabling factors were the presence of expert health personnel to provide training and Pap smear test (50.3%, lack of time and too busy to do Pap smear test (23.2%. The reinforcing factors were the media advice (41.3%, doctor’s advice (32.5% and neglect and forgetfulness (36.2%. Conclusion: This study has shown the Pap smear screening behavior affected by personal factors, family, cultural and economic. Application of PEN-3 can effective in planning and designing intervention programs for cervical cancer screening.

  10. HPV, Cervical Cancer and Pap Test Related Knowledge Among a Sample of Female Dental Students in India.

    Science.gov (United States)

    Doshi, Dolar; Reddy, B Srikanth; Karunakar, P; Deshpande, Kopparesh

    2015-01-01

    The present study was designed to ascertain knowledge about HPV, cervical cancer (CC) and the Pap test among female dental students of Panineeya Institute of Dental Sciences and Hospital, Hyderabad, India. A self-administered questionnaire covering demographic details, knowledge relating to human papilloma virus (HPV) (8 items), cervical cancer (4 items) and the Pap smear (6 items) was employed. Responses were coded as "True, False and Don't Know". Mean and standard deviation (SD) for correct answers and levels of knowledge were determined. Based on the year of study, significant differences in knowledge of HPV were noted for questions on symptoms (p=0.01); transmission from asymptomatic partners (p=0.002); treatment with antibiotics (p=0.002); start of sexual activity (p=0.004); and recommended age for HPV vaccination (p=0.01). For knowledge regarding CC, significance was observed for the age group being affected (p=0.008) and symptoms of the disease in early stages (p=0.001). Indications for Pap smear tests like symptoms' of vaginal discharge (p=0.002), marital status (p=0.01) and women with children (p=0.02) had significant difference based on the year of study. Based on religion, transmission of HPV via pregnancy, HPV related diseases except CC and preventive measures except condom use and oral contraceptives showed significant differences. However, significant variation with religion was observed only for two preventive measures of CC (Pap test; p=0.004) and HPV vaccination (p=0.003). Likewise, only the frequency of Pap test showed a significant difference for religion (p=0.001). This study emphasizes the lack of awareness with regard to HPV, CC and screening with pap smear even among health professionals. Hence, regular health campaigns are essential to reduce the disease burden.

  11. Innovative method of RES integration into the regional energy development scenarios

    International Nuclear Information System (INIS)

    Klevas, Valentinas; Biekša, Kestutis; Murauskaitė, Lina

    2014-01-01

    Scarcity or abundance of energy resources usually depends on physical and geographical conditions in the region. However, the energy flow in the region also depends on the efficient use of energy resources, the consumption rate of energy and the possibility to use local renewable and non-renewable energy resources. Production, distribution and the use of energy resources in the region are the challenges for central and local government, business and social service, customers and other stakeholders. Development of regional energy economy should be optimized according to the available energy flow in the region using a network system analysis method, which provides solutions for developing sustainable energy economy models. The network system analysis method enables to optimize the use of local and renewable resources at the regional level and reveals available local energy resources. An efficient use of available regional resources and the use of renewable energy sources (RES) should be the main goals for the development of regional energy system. RES can compete with traditional fossil fuel with the condition that all hidden aspects are revealed. The network system analysis method enables to indicate energy flows in the region as well as indicate pros and cons of using renewable energy technologies. - Highlights: • RES integration into the regional energy development scenarios is done. • Innovative process network system (PNS) analysis method is used. • PNS method is used to optimize the use of local and renewable resources. • Analysis of energy flow in region using PNS method is done

  12. KLASIFIKASI INTI SEL PAP SMEAR BERDASARKAN ANALISIS TEKSTUR MENGGUNAKAN CORRELATION-BASED FEATURE SELECTION BERBASIS ALGORITMA C4.5

    Directory of Open Access Journals (Sweden)

    Toni Arifin

    2014-09-01

    Full Text Available Abstract - Pap Smear is an early examination to diagnose whether there’s indication cervical cancer or not, the process of observations were done by observing pap smear cell under the microscope. There’s so many research has been done to differentiate between normal and abnormal cell. In this research presents a classification of pap smear cell based on texture analysis. This research is using the Harlev image which amounts to 280 images, 140 images are used as training data and 140 images other are used as testing. On the texture analysis used Gray level Co-occurance Matrix (GLCM method with 5 parameters that is correlation, energy, homogeneity and entropy added by counting the value of brightness. For choose which the best attribute used correlation-based feature selection method and than used C45 algorithm for produce classification rule. The result accuracy of the classification normal and abnormal used decision tree C45 is 96,43% and errors in predicting is 3,57%. Keywords : Classification, Pap Smear cell image, texture analysis, Correlation-based feature selection, C45 algorithm. Abstrak - Pap Smear merupakan pemeriksaan dini untuk mendiagnosa apakah ada indikasi kanker serviks atau tidak, proses pengamatan dilakukan dengan mengamati sel pap smear dibawah mikroskop. Banyak penelitian yang telah dilakukan untuk membedakan antara sel normal dan abnormal. Dalam penelitian ini menyajikan klasifikasi inti sel pap smear berdasarkan analisis tektur. Citra yang digunakan dalam penelitian ini adalah citra Harlev yang berjumlah 280 citra, 140 citra digunakan sebagai data training dan 140 citra lain digunakan sebagai testing. Pada analisis tekstur mengunakan metode Gray level Co-occurrence Matrix (GLCM menggunakan 5 parameter yaitu korelasi, energi, homogenitas dan entropi ditambah dengan menghitung nilai brightness. Untuk memilih mana atribut terbaik digunakan metode correlation-based feature selection lalu digunakan algoritma C45 untuk

  13. The future has come: the 100% RES driven power system is reality

    International Nuclear Information System (INIS)

    Orths, Antje; Borre Eriksen, Peter

    2016-01-01

    The Danish political energy and climate targets fixed in the RES (Renewable Energy Sources) directive require Denmark to reach a 30 % RES share of its total energy consumption in 2020. Besides, Danish national targets aim at wind power production to correspond to 50 % of domestic gross electricity consumption (status in 2015: 42 %). For 2050, the political target is to be free of fossil fuels in the whole energy sector - i.e. including transportation. The major part of variable RES in Denmark is wind energy, the remaining power consumption mainly based on biomass, gas and coal fired central power stations and local CHP plants. Some key figures: at the end of 2015, 5,076 MW wind power capacity and 783 MW of solar power capacity were installed in Denmark, with Danish peak load at ∼6.400 MW and the total electricity consumption at 33.6 TWh. Wind power is split into 3,805 MW onshore and 1.272 MW offshore installations. In 2015, wind power produced 14.1 TWh electricity (9.3 TWh onshore, 4.8 TWh offshore), which made a ∼42 % share of the Danish electricity consumption, while solar power produced 0.6 TWh. The high RES level is already today challenging the system e.g. concerning the need for flexibility on the one hand, or by pushing power plants delivering important system services out of the market on the other hand. To fulfill the political ambitions, new arrangements concerning the technical and market design incentivizing flexibility or ancillary services, such as frequency control and voltage control, are needed and currently under development. This article gives examples and illustrates the urgency by showing a real dispatch in a windy week. (authors)

  14. Electricity market models and RES integration: The Greek case

    International Nuclear Information System (INIS)

    Simoglou, Christos K.; Biskas, Pandelis N.; Vagropoulos, Stylianos I.; Bakirtzis, Anastasios G.

    2014-01-01

    This paper presents an extensive analysis of the Greek electricity market for the next 7-year period (2014–2020) based on an hour-by-hour simulation considering five different RES technologies, namely wind, PV, small hydro, biomass and CHP with emphasis on PV integration. The impact of RES penetration on the electricity market operation is evaluated under two different models regarding the organization of the Greek wholesale day-ahead electricity market: a mandatory power pool for year 2014 (current market design) and a power exchange for the period 2015–2020 (Target Model). An integrated software tool is used for the simulation of the current and the future day-ahead market clearing algorithm of the Greek wholesale electricity market. Simulation results indicate the impact of the anticipated large-scale RES integration, in conjunction with each market model, on specific indicators of the Greek electricity market in the long-term. - Highlights: • Analysis of the Greek electricity market for the next 7-year period (2014–2020) based on hour-by-hour simulation. • Five different RES technologies are considered with emphasis on PV integration. • A power pool (for 2014) and a power exchange (for 2015–2020) are considered. • Various market indicators are used for the analysis of the impact of the RES integration on the Greek electricity market. • Two alternative tariff schemes for the compensation of the new ground-mounted PV units from 2015 onwards are investigated

  15. Barriers to Pap Smear Test for the Second Time in Women Referring to Health Care Centers in the South of Tehran: A Qualitative Approach

    Directory of Open Access Journals (Sweden)

    Laleh Hassani

    2017-10-01

    Full Text Available Background: Cervical cancer is a preventable disease with a regular screening program. Many studies have reported a large number of barriers that women had for the first time, but this study decided to find other barriers for the second time pap smear. Methods: In this qualitative research, data were gathered through in-depth interviews and expressed through conventional content analysis in the form of constant comparison. The participants were 15 women with family profile at 30 health care centers who lived in the south of Tehran and had done Pap smear for one time but didn’t do it for the second time. Results: Three main themes emerged from the analysis of the interviews: negative experiences of the first Pap test were as follows: results of the first time test, readiness for performing the test, getting the test itself, and the site of the first Pap test. Personal barriers to getting the second Pap test were: inattention to time, physical barriers to the second Pap test, and inhibitory beliefs. Perceived social barriers to getting the second Pap test with two sub-themes included social supports and abstract norms. Conclusion: This study provided other barriers about Pap smear including lack of the spouse’s support, the role of health care providers and physicians in screening program for early diagnosis in women.

  16. The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.

    Science.gov (United States)

    Reding, Theresia; Palmiere, Cristian; Pazhepurackel, Clinsyjos; Schiesser, Marc; Bimmler, Daniel; Schlegel, Andrea; Süss, Ursula; Steiner, Sabrina; Mancina, Leandro; Seleznik, Gitta; Graf, Rolf

    2017-05-02

    In patients with infection and sepsis serum levels of Pancreatic Stone protein/regenerating protein I (PSP) are highly elevated. The origin of PSP during these conditions is presumably the pancreas, however, an intestinal origin cannot be excluded. Similarly, pancreatitis-associated protein (PAP) was identified in the pancreas. These proteins were also localized in intestinal organs. Here we aim to elucidate the bio-distribution of PSP and PAP in animal models of sepsis and in healthy humans. PSP and PAP responded to remote lesions in rats although the pancreatic response was much more pronounced than the intestinal. Tissue distribution of PSP demonstrated a 100-fold higher content in the pancreas compared to any other organ while PAP was most abundant in the small intestine. Both proteins responded to CLP or sham operation in the pancreas. PSP also increased in the intestine during CLP. The distribution of PSP and PAP in human tissue mirrored the distribution in the murine models. Distribution of PSP and PAP was visualized by immunohistochemistry. Rats and mice underwent midline laparotomies followed by mobilization of tissue and incision of the pancreatic duct or duodenum. Standard cecum-ligation-puncture (CLP) procedures or sham laparotomies were performed. Human tissue extracts were analyzed for PSP and PAP. The pancreas reacts to remote lesions and septic insults in mice and rats with increased PSP synthesis, while PAP is selectively responsive to septic events. Furthermore, our results suggest that serum PSP in septic patients is predominantly derived through an acute phase response of the pancreas.

  17. Who benefits from cooperation? A numerical analysis of redistribution effects resulting from cooperation in European RES-E support

    International Nuclear Information System (INIS)

    Unteutsch, Michaela

    2014-01-01

    This paper numerically analyzes redistribution effects resulting from cooperation among European countries in achieving the 2020 targets for electricity generation from renewable energy sources (RES-E). The quanti cation of redistribution effects builds on the theoretical analysis by Unteutsch (2014), who shows that cooperation in RES-E support increases overall welfare but is not beneficial for all groups. In this paper, we use a dynamic investment and dispatch optimization model of the European electricity system to investigate which groups potentially benefit from cooperation and which groups would be worse off compared to a situation in which national RES-E targets are reached solely by domestic RES-E production. In the analysis, cooperation in RES-E support is implemented as a European-wide green certificate trading scheme. Main findings of the analysis include that in the European electricity system, effects of the change in the certificate price in most countries would overcompensate for the effects of the change in the wholesale electricity price. Thus, in most countries with comparatively high (low) generation costs for renewable energies, consumer rents increase (decrease) due to cooperation and producers yield lower (higher) profits. In addition, it is found that the magnitude of redistribution effects between the individual groups is quite large: In some countries, the change in consumer rents or producer profits resulting from cooperation is nearly twice as high as the overall welfare effect of cooperation in the whole European electricity system. Moreover, we find that the sign, but not always the magnitude, of redistribution effects is quite robust to different developments of interconnector extensions, the CO 2 price and RES-E investment costs.

  18. Who benefits from cooperation? A numerical analysis of redistribution effects resulting from cooperation in European RES-E support

    Energy Technology Data Exchange (ETDEWEB)

    Unteutsch, Michaela

    2014-01-15

    This paper numerically analyzes redistribution effects resulting from cooperation among European countries in achieving the 2020 targets for electricity generation from renewable energy sources (RES-E). The quanti cation of redistribution effects builds on the theoretical analysis by Unteutsch (2014), who shows that cooperation in RES-E support increases overall welfare but is not beneficial for all groups. In this paper, we use a dynamic investment and dispatch optimization model of the European electricity system to investigate which groups potentially benefit from cooperation and which groups would be worse off compared to a situation in which national RES-E targets are reached solely by domestic RES-E production. In the analysis, cooperation in RES-E support is implemented as a European-wide green certificate trading scheme. Main findings of the analysis include that in the European electricity system, effects of the change in the certificate price in most countries would overcompensate for the effects of the change in the wholesale electricity price. Thus, in most countries with comparatively high (low) generation costs for renewable energies, consumer rents increase (decrease) due to cooperation and producers yield lower (higher) profits. In addition, it is found that the magnitude of redistribution effects between the individual groups is quite large: In some countries, the change in consumer rents or producer profits resulting from cooperation is nearly twice as high as the overall welfare effect of cooperation in the whole European electricity system. Moreover, we find that the sign, but not always the magnitude, of redistribution effects is quite robust to different developments of interconnector extensions, the CO{sub 2} price and RES-E investment costs.

  19. RES Hydrogen: efficient pressurised alkaline electrolysers

    DEFF Research Database (Denmark)

    Bowen, Jacob R.; Bentzen, Janet Jonna; Jørgensen, Peter Stanley

    The RESelyser project addresses issues associated with coupling alkaline electrolysis to renewable energy sources such as electrode stability and gas purity by implementing improved electrodes and a new separator membrane concept. The project aims to improve performance, operation pressure...... and reduce system cost. The project supports DTU Energy's activities on electrodes within the larger FCH-JU project. The overall project demonstrated: improved electrode efficiency also during cyclic operation, safe gas purity at a system pressure of 30 bar, 10 kW stack operation and estimated system costs...

  20. Intricate Resonant Raman Response in Anisotropic ReS2.

    Science.gov (United States)

    McCreary, Amber; Simpson, Jeffrey R; Wang, Yuanxi; Rhodes, Daniel; Fujisawa, Kazunori; Balicas, Luis; Dubey, Madan; Crespi, Vincent H; Terrones, Mauricio; Hight Walker, Angela R

    2017-10-11

    The strong in-plane anisotropy of rhenium disulfide (ReS 2 ) offers an additional physical parameter that can be tuned for advanced applications such as logic circuits, thin-film polarizers, and polarization-sensitive photodetectors. ReS 2 also presents advantages for optoelectronics, as it is both a direct-gap semiconductor for few-layer thicknesses (unlike MoS 2 or WS 2 ) and stable in air (unlike black phosphorus). Raman spectroscopy is one of the most powerful characterization techniques to nondestructively and sensitively probe the fundamental photophysics of a 2D material. Here, we perform a thorough study of the resonant Raman response of the 18 first-order phonons in ReS 2 at various layer thicknesses and crystal orientations. Remarkably, we discover that, as opposed to a general increase in intensity of all of the Raman modes at excitonic transitions, each of the 18 modes behave differently relative to each other as a function of laser excitation, layer thickness, and orientation in a manner that highlights the importance of electron-phonon coupling in ReS 2 . In addition, we correct an unrecognized error in the calculation of the optical interference enhancement of the Raman signal of transition metal dichalcogenides on SiO 2 /Si substrates that has propagated through various reports. For ReS 2 , this correction is critical to properly assessing the resonant Raman behavior. We also implemented a perturbation approach to calculate frequency-dependent Raman intensities based on first-principles and demonstrate that, despite the neglect of excitonic effects, useful trends in the Raman intensities of monolayer and bulk ReS 2 at different laser energies can be accurately captured. Finally, the phonon dispersion calculated from first-principles is used to address the possible origins of unexplained peaks observed in the Raman spectra, such as infrared-active modes, defects, and second-order processes.

  1. Fluorescence Spectrum and Decay Measurement for Hsil VS Normal Cytology Differentiation in Liquid Pap Smear Supernatant

    Science.gov (United States)

    Vaitkuviene, A.; Gegzna, V.; Juodkazis, S.; Jursenas, S.; Miasojedovas, S.; Kurtinaitiene, R.; Rimiene, J.; Vaitkus, J.

    2009-06-01

    Cervical smear material contains endo and exocervical cells, mucus and inflammative, immune cells in cases of pathology. Just not destroyed keratinocytes lay on the glass for microscopy. Liquid cytology supernatant apart other diagnostics could be used for photodiagnostic. The spectroscopic parameters suitable for Normal and HSIL cytology groups supernatant differentiation are demonstrated. The dried liquid PAP supernatant fractions—sediment and liquid were investigated. Excitation and emission matrices (EEM), supernatant fluorescence decay measured under 280 nm diode short pulse excitation and fluorescence spectroscopy by excitation with 355 nm laser light were analyzed. The differences between Normal and HSIL groups were statistically proven in the certain spectral regions. Fluorescence decay peculiarities show spectral regions consisting of few fluorophores. Obtained results on fluorescence differences in Normal and HSIL groups' supernatant shows the potency of photodiagnosis application in cervical screening.

  2. Pap Smear Diagnosis Using a Hybrid Intelligent Scheme Focusing on Genetic Algorithm Based Feature Selection and Nearest Neighbor Classification

    DEFF Research Database (Denmark)

    Marinakis, Yannis; Dounias, Georgios; Jantzen, Jan

    2009-01-01

    The term pap-smear refers to samples of human cells stained by the so-called Papanicolaou method. The purpose of the Papanicolaou method is to diagnose pre-cancerous cell changes before they progress to invasive carcinoma. In this paper a metaheuristic algorithm is proposed in order to classify t...... other previously applied intelligent approaches....

  3. Mammography and Pap test screening among low-income foreign-born Hispanic women in the USA

    Directory of Open Access Journals (Sweden)

    Fernandez Maria E.

    1998-01-01

    Full Text Available Little is known about the factors influencing screening among low-income Hispanic women particularly among recent immigrants. A sample of 148 low-income, low-literate, foreign-born Hispanic women residing in the Washington DC metropolitan area participated in the study. The mean age of the sample was 46.2 (SD = 11.5, 84% reported annual household incomes<=$15,000. All women were Spanish speakers and had low acculturation levels. Ninety six percent had reported having a Pap smear, but 24% were not in compliance with recommended screening (Pap test within the last 3 years. Among women 40 and older, 62% had received a mammogram, but only 33% were compliant with age appropriate recommended mammography screening guidelines. Women in this study had more misconceptions about cancer than Hispanics in other studies. Multivariate logistic models for correlates of Pap test and mammography screening behavior indicate that factors such as fear of the screening test, embarrassment, and lack of knowledge influenced screening behavior. In conclusion, women in this study had lower rates of mammography screening than non-Hispanic women and lower rates of compliance with recommended Mammography and Pap test screening guidelines.

  4. Awareness of cervical cancer and Pap smear among nursing staff at a rural tertiary care hospital in Central India.

    Science.gov (United States)

    Jain, S M; Bagde, M N; Bagde, N D

    2016-01-01

    Cancer cervix is the leading cause of cancer deaths in females in developing countries and one in five women suffering from cervical cancer lives in India. The aim of this study is to determine the awareness about cervical cancer and Pap smear among nurses working in a tertiary care institute. Study Setting and Design: Cross-sectional survey in a tertiary care institute. Nurses working at our institute excluding those who have worked or working in the Obstetrics and Gynecology department were provided with a pre-designed questionnaire testing their knowledge about cervical cancer. Approximately, 86% were aware about cancer cervix and 69% were aware of a pre-cancerous stage. 42.3% were not aware of any risk factor and 27.6% were not aware of any symptom of cancer cervix. 86.2% were aware about Pap smear, but only 58.6% were aware that facilities of Pap smear were available at our hospital. Knowledge about cervical cancer and awareness of Pap smear as screening test was inadequate in nursing staff. Awareness programs about cervical cancer and screening are needed to increase awareness for this preventable condition. There is a need to arrange reorientation programs to sensitize nurses and establish cytology clinics to offer facilities for easily accessible and affordable screening.

  5. Perception and Experience of Primary Care Physicians on Pap Smear Screening for Women with Intellectual Disabilities: A Preliminary Finding

    Science.gov (United States)

    Lin, Jin-Ding; Sung, Chang-Lin; Lin, Lan-Ping; Liu, Ta-Wen; Lin, Pei-Ying; Chen, Li-Mei; Chu, Cordia M.; Wu, Jia-Ling

    2010-01-01

    This study aims to establish evidence-based data to explore the perceptions and experience of primary care physicians in the Pap smear screening provision for women with intellectual disabilities (ID), and to analyze the associated factors in the delivery of screening services to women with ID in Taiwan. Data obtained by a cross-sectional survey…

  6. A heterodimer of human 3'-phospho-adenosine-5'-phosphosulphate (PAPS) synthases is a new sulphate activating complex

    International Nuclear Information System (INIS)

    Grum, Daniel; Boom, Johannes van den; Neumann, Daniel; Matena, Anja; Link, Nina M.; Mueller, Jonathan W.

    2010-01-01

    3'-Phospho-adenosine-5'-phosphosulphate (PAPS) synthases are fundamental to mammalian sulphate metabolism. These enzymes have recently been linked to a rising number of human diseases. Despite many studies, it is not yet understood how the mammalian PAPS synthases 1 and 2 interact with each other. We provide first evidence for heterodimerisation of these two enzymes by pull-down assays and Foerster resonance energy transfer (FRET) measurements. Kinetics of dimer dissociation/association indicates that these heterodimers form as soon as PAPSS1 and -S2 encounter each other in solution. Affinity of the homo- and heterodimers were found to be in the low nanomolar range using anisotropy measurements employing proteins labelled with the fluorescent dye IAEDANS that - in spite of its low quantum yield - is well suited for anisotropy due to its large Stokes shift. Within its kinase domain, the PAPS synthase heterodimer displays similar substrate inhibition by adenosine-5'-phosphosulphate (APS) as the homodimers. Due to divergent catalytic efficacies of PAPSS1 and -S2, the heterodimer might be a way of regulating PAPS synthase function within mammalian cells.

  7. Evaluation of a low-cost liquid-based Pap test in rural El Salvador: a split-sample study.

    Science.gov (United States)

    Guo, Jin; Cremer, Miriam; Maza, Mauricio; Alfaro, Karla; Felix, Juan C

    2014-04-01

    We sought to test the diagnostic efficacy of a low-cost, liquid-based cervical cytology that could be implemented in low-resource settings. A prospective, split-sample Pap study was performed in 595 women attending a cervical cancer screening clinic in rural El Salvador. Collected cervical samples were used to make a conventional Pap (cell sample directly to glass slide), whereas residual material was used to make the liquid-based sample using the ClearPrep method. Selected samples were tested from the residual sample of the liquid-based collection for the presence of high-risk Human papillomaviruses. Of 595 patients, 570 were interpreted with the same diagnosis between the 2 methods (95.8% agreement). There were comparable numbers of unsatisfactory cases; however, ClearPrep significantly increased detection of low-grade squamous intraepithelial lesions and decreased the diagnoses of atypical squamous cells of undetermined significance. ClearPrep identified an equivalent number of high-grade squamous intraepithelial lesion cases as the conventional Pap. High-risk human papillomavirus was identified in all cases of high-grade squamous intraepithelial lesion, adenocarcinoma in situ, and cancer as well as in 78% of low-grade squamous intraepithelial lesions out of the residual fluid of the ClearPrep vials. The low-cost ClearPrep Pap test demonstrated equivalent detection of squamous intraepithelial lesions when compared with the conventional Pap smear and demonstrated the potential for ancillary molecular testing. The test seems a viable option for implementation in low-resource settings.

  8. Reinsalu : Res Publica lisab kiirust / Urmas Reinsalu ; interv. Lauri Tankler

    Index Scriptorium Estoniae

    Reinsalu, Urmas, 1975-

    2004-01-01

    Ilmunud ka: Võta Võim : na russkom jazõke, 28. apr. 2004, lk. 4. Res Publica esikandidaat Urmas Reinsalu erakonna valimiskampaania eesmärkidest, võimalustest nende eesmärkide saavutamiseks ja erakonna valimisprogrammi ning kandidaatide eelistest konkurentide ees

  9. Resúmenes Presentaciones de Pósteres

    Directory of Open Access Journals (Sweden)

    Editor Gabriel Vargas Arana

    2015-12-01

    Full Text Available En este artículo se pueden encontrar los resúmenes de las presentaciones de pósteres del III Congreso Latinoamericano de Plantas Medicinales, desarrollado del 12 al 14 de agosto de 2015 en la ciudad de Iquitos, Perú.

  10. Medical negligence and res ipsa loquitur in South Africa | Patel ...

    African Journals Online (AJOL)

    The inter-relationship between Medicine and Law is most commonly brought to the fore by cases involving medical negligence. This relationship needs to protect all parties concerned based on the probability of reasonableness in terms of who performs the act as well as the patient affected by the act in question. The res ...

  11. Pettumus Res Publicas algas kirikus antud vandest / Margus Tsahkna

    Index Scriptorium Estoniae

    Tsahkna, Margus, 1977-

    2005-01-01

    Autori sõnul on Res Publica petnud inimeste põhiväärtustele tuginevaid ootusi, Eesti riik kaugeneb kodanikust ja tema elulistest huvidest. Isamaaliit paneb ette asuda tegelike probleemide lahendamisele ning kutsub erakondi üles kaitsma rahvuslikke huve

  12. Au Cern, premières collisions de protons hier

    CERN Multimedia

    Galeazzi, Juliette

    2009-01-01

    "Hier, les scientifiques du monde entier ont salué le redémarrage du LHC, grand collisionneur de hadrons, au Cern à Genève. Après quatorze mois d'arrêt, à la suite d'une panne, les expériences ont pris et les premières collisions ont eu lieu" (2 pages)

  13. Res Publica tähistab sünnipäeva konverentsiga / Lauri Tankler

    Index Scriptorium Estoniae

    Tankler, Lauri

    2003-01-01

    Ilmunud ka: Võta Võim : na russkom jazõke 3. dets. lk. 3. Res Publica saab 2-aastaseks, mille puhul korraldatakse konverents "Riik ja Res Publica". Vt. samas: Selle aasta veebruaris said kuldmärgid

  14. Res Publica kärbiks võimuorganite koosseise / Argo Ideon

    Index Scriptorium Estoniae

    Ideon, Argo, 1966-

    2002-01-01

    Res Publica taotleb Riigikogu kärpimist 61 liikmeni, lubab kahandada kohalike volikogude koosseise, Tallinna abilinnapeade arvu ja kaotada portfellita ministrite kohad. Vt. samas: Res Publica valimisnimekiri Tallinnas

  15. Res Publica asus Reformierakonda Tallinna võimuliidust tõrjuma / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2005-01-01

    Res Publica Tallinna piirkonna juhatuse liikme Siim Roode sõnul teeb Res Publica Keskerakonna Tallinna piirkonna juhatusele ettepaneku koalitsiooniläbirääkimiste alustamiseks. Lisa: Paltsu ettekäändeks Unicom

  16. Res Publica hakkab kaaluma Kohtla-Järve võimuliidust lahkumist / Erik Gamzejev

    Index Scriptorium Estoniae

    Gamzejev, Erik, 1967-

    2002-01-01

    Ilmunud ka: Severnoje Poberezhje 19. nov. lk. 1. Res Publica eestseisuse ettepanek Kohtla-Järve osakonnale lahkuda koalitsioonist. Osakonna juhatuse otsus esitada Hants Hint volikogu esimehe kandidaadiks. Res Publica liikmete käitumise arutelu aukohtus

  17. Res Publica presidendikandidaatide nimed selguvad neljapäevaks / Rauno Veri, Urmo Kübar

    Index Scriptorium Estoniae

    Veri, Rauno, 1978-

    2006-01-01

    Res Publica, Isamaaliit, Reformierakond, SDE ja Keskerakond otsivad ühist presidendikandidaati, ainsa parlamendierakonnana ei osale läbirääkimistel Rahvaliit. Reformierakonna, SDE presidendikandidaatidest; Res Publica naiskogu ja Väärikate Kogu ühisavaldusest

  18. Sisetülides Res Publica heitis liidu Keskerakonnaga kõrvale / Urmas Seaver

    Index Scriptorium Estoniae

    Seaver, Urmas, 1973-

    2005-01-01

    Res Publica juhatus otsustas toetada senise koalitsiooni jätkamist Tallinnas. Res Publica ja Reformierakonna täiendatud koalitsioonileppest. Reformierakonna Tallinna piirkonna juhi Keit Pentuse hinnang võimutülile. Lisa: Võimuleppe lisa

  19. Res Publica : umbusaldamine võib lõpetada senise koalitsiooni / Villy Paimets

    Index Scriptorium Estoniae

    Paimets, Villy, 1972-

    2005-01-01

    Res Publica erakorraline volikogu avaldas toetust justiitsministrile ja andis peaministrile volitused lõpetada justiitsministri umbusaldamise korral senine koalitsioon ning alustada läbirääkimisi Isamaaliiduga. Lisa: Res Publica toetab Vaherit

  20. Res Publica andis kolmele poliitikule fiktiivse elukoha / Kärt Karpa

    Index Scriptorium Estoniae

    Karpa, Kärt, 1973-

    2002-01-01

    Väidetavalt lasi Res Publica enne kohalikke valimisi ühte Pirita eramajja sisse registreerida Jaanus Rahumäe ja veel kaks Res Publica liiget, et nad saaksid kandideerida Tallinna volikogusse ja Pirita halduskogusse

  1. Riigikogu aseesimeeste valimine tekitas paksu verd : Res Publical riigikogu juhatuses kaks kohta / Katrin Pauts

    Index Scriptorium Estoniae

    Pauts, Katrin, 1977-

    2005-01-01

    Riigikogu aseesimeesteks valiti Res Publica liige Taavi Veskimägi ja Keskerakonna liige Toomas Varek. Opositsiooniparteil Res Publica on nüüd juhatuses kaks kohta. Erakondade juhtpoliitikute kommentaare

  2. RES scintigraphy in polycythemia vera and secondary or relative polycythemia

    Energy Technology Data Exchange (ETDEWEB)

    Rudberg, U. (Depts. of Diagnostic Radiology and Internal Medicine, St. Goeran' s Hospital, Stockholm (Sweden)); Skaarberg, K.O. (Depts. of Diagnostic Radiology and Internal Medicine, St. Goeran' s Hospital, Stockholm (Sweden))

    1993-03-01

    Scintigraphy of the reticuloendothelial system (RES) was performed in 19 patients with polycythemia vera (PCV) and in 18 with secondary or relative polycythemia (PS). Bone marrow extension was found in all patients with PCV and in 11 of 18 patients with PS. The patients with PCV had a higher degree of extension than those with PS. Increased pelvic bone marrow activity was found in 16 of 19 PCV patients, but in none with PS. Splenomegaly was found in 9 patients with PCV, and in none with PS. It is concluded that RES scintigraphy in the majority of patients may differentiate between PCV and PS using the parameters pelvic bone marrow activity, bone marrow extension and splenic size. (orig.).

  3. RES scintigraphy in polycythemia vera and secondary or relative polycythemia

    International Nuclear Information System (INIS)

    Rudberg, U.; Skaarberg, K.O.

    1993-01-01

    Scintigraphy of the reticuloendothelial system (RES) was performed in 19 patients with polycythemia vera (PCV) and in 18 with secondary or relative polycythemia (PS). Bone marrow extension was found in all patients with PCV and in 11 of 18 patients with PS. The patients with PCV had a higher degree of extension than those with PS. Increased pelvic bone marrow activity was found in 16 of 19 PCV patients, but in none with PS. Splenomegaly was found in 9 patients with PCV, and in none with PS. It is concluded that RES scintigraphy in the majority of patients may differentiate between PCV and PS using the parameters pelvic bone marrow activity, bone marrow extension and splenic size. (orig.)

  4. Plastic spatula with narrow long tip provides higher satisfactory smears for Pap test

    Directory of Open Access Journals (Sweden)

    Pervinder Kaur

    2013-01-01

    Full Text Available Background: Ayre spatula for cervical smear collection is being used despite the suggestion that different modified spatulas provide more satisfactory sampling. Aims: To see whether the cytological pickup improves with the use of long tipped spatula. Setting and Design: Rurally based University Hospital; crossover study. Materials and Methods: Pap smear using Ayre spatula in 500 and with plastic narrow long tip (Szalay spatula in 500 clinic attending women was taken and analyzed. Crossover smears were taken with modified spatula in 163 and using Ayre spatula in 187 women after 2 weeks of initial smears. The same pathologist made cytological reporting for all smears and was unaware of the type of spatula used. Results: Smears from Ayre spatula had significantly higher reports of inadequate smears (94 of 500 vs. 68 of 500 for Ayre and Szalay, respectively; P = 0.032 and it remained so even after crossover (94 of 187 vs. 70 of 163 for Ayre and Szalay, respectively; P = 0.2. Cellular quality appeared better with smears taken using Szalay spatula, but the overall abnormal smear detection rate remained similar with either collection tool (χ2 = 1.5; P = 0.2. Conclusions: Proportion of satisfactory smears is higher when long tip plastic spatula is used for collection of sample.

  5. Plastic spatula with narrow long tip provides higher satisfactory smears for Pap test.

    Science.gov (United States)

    Kaur, Pervinder; Kushtagi, Pralhad

    2013-07-01

    Ayre spatula for cervical smear collection is being used despite the suggestion that different modified spatulas provide more satisfactory sampling. To see whether the cytological pickup improves with the use of long tipped spatula. Rurally based University Hospital; crossover study. Pap smear using Ayre spatula in 500 and with plastic narrow long tip (Szalay) spatula in 500 clinic attending women was taken and analyzed. Crossover smears were taken with modified spatula in 163 and using Ayre spatula in 187 women after 2 weeks of initial smears. The same pathologist made cytological reporting for all smears and was unaware of the type of spatula used. Smears from Ayre spatula had significantly higher reports of inadequate smears (94 of 500 vs. 68 of 500 for Ayre and Szalay, respectively; P = 0.032) and it remained so even after crossover (94 of 187 vs. 70 of 163 for Ayre and Szalay, respectively; P = 0.2). Cellular quality appeared better with smears taken using Szalay spatula, but the overall abnormal smear detection rate remained similar with either collection tool (χ(2) = 1.5; P = 0.2). Proportion of satisfactory smears is higher when long tip plastic spatula is used for collection of sample.

  6. Non-invasive methods for estimating mPAP in COPD using cardiovascular magnetic resonance imaging

    International Nuclear Information System (INIS)

    Johns, C.S.; Capener, D.A.; Oram, C.; Wild, J.M.; Rajaram, S.; Elliot, C.; Condliffe, R.; Kiely, D.G.; Swift, A.J.

    2018-01-01

    Pulmonary hypertension (PH) is associated with a poor outcome in chronic obstructive pulmonary disease (COPD) and is diagnosed invasively. We aimed to assess the diagnostic accuracy and prognostic value of non-invasive cardiovascular magnetic resonance (CMR) models. Patients with COPD and suspected PH, who underwent CMR and right heart catheter (RHC) were identified. Three candidate models were assessed: 1, CMR-RV model, based on right ventricular (RV) mass and interventricular septal angle; 2, CMR PA/RV includes RV mass, septal angle and pulmonary artery (PA) measurements; 3, the Alpha index, based on RV ejection fraction and PA size. Of 102 COPD patients, 87 had PH. The CMR-PA/RV model had the strongest diagnostic accuracy (sensitivity 92%, specificity 80%, positive predictive value 96% and negative predictive value 63%, AUC 0.93, p<0.0001). Splitting RHC-mPAP, CMR-RV and CMR-PA/RV models by 35mmHg gave a significant difference in survival, with log-rank chi-squared 5.03, 5.47 and 7.10. RV mass and PA relative area change were the independent predictors of mortality at multivariate Cox regression (p=0.002 and 0.030). CMR provides diagnostic and prognostic information in PH-COPD. The CMR-PA/RV model is useful for diagnosis, the RV mass index and PA relative area change are useful to assess prognosis. (orig.)

  7. No increased risk for cervical cancer after a broader definition of a negative Pap smear

    DEFF Research Database (Denmark)

    Rebolj, Matejka; van Ballegooijen, Marjolein; van Kemenade, Folkert

    2008-01-01

    in 1996, the proportion of these smears dropped from 10% to less than 2%. Because this may have caused a loss in smear sensitivity, we analysed the changes in the incidence of cervical cancer after a negative Pap smear. All negative smears made at ages 30-64 in 1990-1995 (n = 1,546,252) and 1998-2006 (n...... = 3,552,716), registered in the national registry of histo- and cytopathology (PALGA), were followed for up to 9 years. During follow-up of the 1990-1995 smears, 377 women developed cervical cancer within 5,232,959 woman-years at risk, while during the follow-up of the 1998-2006 smears, 619 women...... developed cervical cancer within 11,210,675 woman-years at risk. The cumulative incidence after the definition change was not significantly higher than before: e.g. at 6 years, the cumulative incidence for smears made in 1990-1995 was 46 per 100,000 (95% CI: 41-52), and for smears in 1998-2006 was 48 per...

  8. Further developments of the RES3T sorption database

    International Nuclear Information System (INIS)

    Brendler, V.

    2002-01-01

    RES 3 T - the Rossendorf expert system for surface and sorption thermodynamics currently under development has been expanded towards the provision of comprehensive sorption data sets suitable for complex natural systems of rocks and soils. Also a statistical evaluation of the available SCM (surface complexation model) data is now implemented. Finally, a normalization of SCM parameters to a standard site density has been incorporated. (orig.)

  9. Comparison of knowledge and attitudes toward human papillomavirus, HPV vaccine, pap tests, and cervical cancer between US and Peruvian women.

    Science.gov (United States)

    Han, Chi-Son; Ferris, Daron G; Waller, Jennifer; Tharp, Philip; Walter, Jessica; Allmond, Lynn

    2012-04-01

    The purpose of this study was to determine and compare the knowledge and attitudes toward human papillomavirus (HPV), HPV vaccine, Pap tests, and cervical cancer among US and Peruvian women. A convenience sample of 275 US women in Augusta, GA, and 702 Peruvian women living in or near Cusco, Peru, completed 22- or 21-item questionnaires, respectively. These questionnaires determined their knowledge about HPV, the HPV vaccine, Pap tests, and cervical cancer. Simple logistic regression was used to determine the relationship between location and language on the correct responses. Odds ratios (ORs) and 95% confidence intervals were calculated. US Spanish- (OR = 0.02), Quechua- (OR = 0.05), and Peru Spanish-speaking women (OR = 0.03) were significantly less likely to know that HPV causes cervical cancer compared with US non-Spanish-speaking women. US Spanish- (OR = 10.61, OR = 5.74), Quechua- (OR = 11.08, OR = 9.89), and Peru Spanish-speaking women (OR = 17.25, 14.43) were significantly more likely to be embarrassed and afraid, respectively, to get a Pap test compared with US non-Spanish-speaking women. US Spanish- (OR = 0.11), Quechua- (OR = 0.14), and Peru Spanish-speaking women (OR = 0.11) women were significantly less likely to know the HPV vaccine is safe and effective compared with US non-Spanish-speaking women. Education must be implemented to address serious misconceptions and worrisome attitudes toward Pap tests and the HPV vaccine to decrease the rate of cervical cancer in Peru and US Spanish-speaking women.

  10. Res Publica pakub sponsoritele anonüümsust / Virkko Lepassalu

    Index Scriptorium Estoniae

    Lepassalu, Virkko, 1971-

    2003-01-01

    Mõnede tõenäoliselt Res Publica lähedaste ettevõtjate seas levib erakonna nimel rahapalumiskiri, mis lubab sponsorile anonüümsust. Vt. samas: Telefonikõne ettevõtja ja Res Publica aseesimehe Ken-Marti Vaheri vahel ; Teisedki on saanud rahaallikaid varjates ; Res Publica on loobunud reklaamibroneeringutest

  11. Res Publica aukohus heidab juhtidele ette eetikavääratust / Toomas Mattson

    Index Scriptorium Estoniae

    Mattson, Toomas, 1970-

    2002-01-01

    Ilmunud ka: Põhjarannik ; Severnoje Poberezhje 22. november lk. 3;4. Res Publica aukohus arvab, et Res Publica juhid on rikkunud erakonna põhikirja, sisekorda ja eetikakoodeksit Kohtla-Järve juhtumi lahendamisel. Kohtla-Järvel sai linnapeaks riisumiskahtlusega uurimise all olev Valeri Korb tänu Keskerakonna ja Res Publica koalitsioonileppele. Kommenteerib Juhan Kivirähk

  12. Res Publica toetus pole aastaga üle viie protsendi tõusnud / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2006-01-01

    Emori jaanuarikuu küsitluse põhjal on 22 protsendiga suurim toetajaskond Keskerakonnal, Res Publica reiting on aasta aega püsinud viie ja kolme toetusprotsendi vahel. Vt. samas: Taavi Veskimägi. 2 küsimust. Diagrammid: Res Publica valiks riigikogusse tagasi vaid kolm protsenti valijaist; Toetus Res Publicale

  13. Res Publica ladvikus hõõgub võimutüli / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2006-01-01

    22. aprillil kogunenud Res Publica volikogu toetas 60 poolthäälega ühe vastu Res Publica ja Isamaaliidu ühinemist. Tõnis Palts teatas volikogul esinedes, et Taavi Veskimägi ei sobi Res Publica poolseks läbirääkimiste juhiks

  14. Res Publicas käärib mäss / Hants Hint

    Index Scriptorium Estoniae

    Hint, Hants

    2002-01-01

    Res Publica eestseisuse liige ja Ida-Viru piirkonna esimees Hants Hint vastab küsimustele Res Publica ja Keskerakonna võimuliidu moodustamisega tekkinud skandaali, Res Publica esimehe Juhan Partsiga kohtumise kohta. Vt. samas: "Korbi toetajaid ootab hukkamõist"

  15. Biochemical characterization of the triticale TsPAP1, a new type of plant prolyl aminopeptidase, and its impact on proline content and flowering time in transgenic Arabidopsis plants.

    Science.gov (United States)

    Zdunek-Zastocka, Edyta; Grabowska, Agnieszka; Branicki, Tomasz; Michniewska, Beata

    2017-07-01

    Proline aminopeptidase (PAP, EC 3.4.11.5) is the only enzyme that effectively releases proline from the N-termini of peptides. The amino acid sequence of the PAP from Triticosecale, TsPAP1, comprises conserved regions, characteristic of the monomeric forms of PAP found in bacteria but not yet identified in plants. Therefore, we aimed to obtain and biochemically characterize the TsPAP1 protein. The recombinant TsPAP1 protein was received through heterologous expression of the TsPAP1 coding sequence in a bacterial expression system and purified with affinity chromatography. Gel filtration chromatography and SDS electrophoresis revealed that TsPAP1 is a monomer with a molecular mass of 37.5 kDa. TsPAP1 prefers substrates with proline at the N-terminus but is also capable of hydrolyzing β-naphthylamides of hydroxyproline and alanine. Among the peptides tested, the most preferred were di- and tripeptides, especially those with glycine in the Y position. The use of diagnostic inhibitors indicated that TsPAP1 is a serine peptidase; however, further characterization revealed that the SH residues are also important for maintaining its activity. To examine the role of TsPAP1 under physiological conditions, we developed transgenic Arabidopsis plants overexpressing TsPAP1. Compared with wild-type plants, the transgenic lines accumulated more proline, flowered an average of 3.5 days earlier, and developed more siliques than did untransformed controls. Our paper is the first to describe the biochemical properties of a novel monomeric plant PAP and contributes to the functional characterization of PAP proteins in plants. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  16. Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107, and SEM2(49-107 seminal amyloid fibrils

    Directory of Open Access Journals (Sweden)

    Laura M. Castellano

    2015-09-01

    Full Text Available Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120 and semenogelins (SEM1 and SEM2 that potently enhance HIV infectivity. Amyloid but not soluble forms of these peptides enhance HIV infection. Thus, agents that remodel these amyloid fibrils could prevent HIV transmission. Here, we confirm that the green tea polyphenol, epigallocatechin-3-gallate (EGCG, slowly remodels fibrils formed by PAP248-286 termed SEVI (semen derived enhancer of viral infection and also exerts a direct anti-viral effect. We elucidate for the first time that EGCG remodels PAP85-120, SEM1(45-107, and SEM2(49-107 fibrils more rapidly than SEVI fibrils. We establish EGCG as the first small molecule that can remodel all four classes of seminal amyloid. The combined anti-amyloid and anti-viral properties of EGCG could have utility in preventing HIV transmission.

  17. Papéis, comportamentos, atividades e relações entre membros da família baiana

    Directory of Open Access Journals (Sweden)

    Elaine Pedreira Rabinovich

    2012-04-01

    Full Text Available Este estudo objetivou comparar os dados sobre papéis, comportamentos, atividades e relações entre os membros da família obtidos por Georgas, Berry, Vijver, Kagitçibasi e Poortinga (2006, com dados da família baiana. Para tanto, 170 universitários baianos responderam questionário com questões fechadas enfocando papéis, comportamentos, atividades e relações entre os seguintes membros da família: pai, mãe, avô, avó, tio/tia, menino e menina de 10 anos, moça e rapaz de 20 anos. Os dados foram analisados utilizando o programa Statistical Package for the Social Sciences (SPSS. Em conformidade com o estudo de referência, a mãe é a figura central nas famílias baianas e o pai compartilha o poder financeiro com ela, porém, as atividades domésticas de limpar, cozinhar e lavar ficam mais a cargo dos membros femininos. As avós sucedem aos pais na importância nos papéis familiares e há mais uma interdependência emocional do que econômica/funcional com relação à criança.

  18. Factors related to failure to attend the consultation to receive the results of the Pap smear test1

    Science.gov (United States)

    Vasconcelos, Camila Teixeira Moreira; Cunha, Denise de Fátima Fernandes; Coelho, Cássia Fernandes; Pinheiro, Ana Karina Bezerra; Sawada, Namie Okino

    2014-01-01

    Objective to identify the factors related to the failure of women to attend the follow-up consultation to receive the results of the Pap smear test. Method a cross-sectional study, carried out with 775 patients who underwent the Pap smear test in the Centro de Saúde da Família of Fortaleza, between September 2010 and February 2011. Results the majority of the women studied were young (≤35 years), had low levels of education (≤7 years of study), and commenced sexual activity early (≤20 years), with 17.0% of them failing to return to receive the test results. Statistically significant results for the failure to return were related to: young women (p=0.001); early onset of sexual activity (p=0.047); and inadequate knowledge about the Pap smear test (p=0.029). Conclusion the fact that the women failed to return for the result is a problem for the control of cervical cancer and must be addressed through educational strategies that reinforce the importance of the return for the early detection of this cancer. PMID:25029050

  19. Educational intervention on knowledge of cervical cancer and uptake of Pap smear test among market women in Niger State, Nigeria.

    Science.gov (United States)

    Gana, Godwin Jiya; Oche, Mansur O; Ango, Jessica Timane; Kaoje, Aminu Umar; Awosan, Kehinde Joseph; Raji, Ismail A

    2017-12-31

    Cervical cancer is the most common female genital tract carcinoma worldwide. It is increasingly becoming the leading carcinoma seen among women in the developing world. The aim of our study was to showcase the effect of educational intervention on the knowledge of cervical cancer and subsequently the uptake of Pap smear test amongst market women in Niger state, Nigeria. The state has a rich network of markets in all the local government areas because of the fishing activities, bountiful agricultural produce yearly and its situation to the North of the national capital, Abuja. This was a quasi-experimental study conducted in two groups with pre and post intervention data collection. Sample size was determined based on a previous similar study done in Nigeria. Multi stage sampling technique was used for recruiting the study participants. SPSS statistical software was used for data entry, editing and analysis. Respondents' knowledge of cervical cancer were comparable at pre-intervention but were statistically significantly better (P<0.0001) at post-intervention in the intervention group compared to the control group for every variable measured. However, there was only a (Fisher's exact, P=0.621) compared to the control group. This study showed an increase in knowledge about cervical cancer and Pap smear test however the uptake of Pap smear test remained low even after intervention. This underscores the need for sustained intervention programs to eventually translate knowledge acquired to habitual practice.

  20. Factors related to failure to attend the consultation to receive the results of the Pap smear test

    Directory of Open Access Journals (Sweden)

    Camila Teixeira Moreira Vasconcelos

    2014-06-01

    Full Text Available OBJECTIVE: to identify the factors related to the failure of women to attend the follow-up consultation to receive the results of the Pap smear test.METHOD: a cross-sectional study, carried out with 775 patients who underwent the Pap smear test in the Centro de Saúde da Família of Fortaleza, between September 2010 and February 2011.RESULTS: the majority of the women studied were young (≤35 years, had low levels of education (≤7 years of study, and commenced sexual activity early (≤20 years, with 17.0% of them failing to return to receive the test results. Statistically significant results for the failure to return were related to: young women (p=0.001; early onset of sexual activity (p=0.047; and inadequate knowledge about the Pap smear test (p=0.029. Conclusion the fact that the women failed to return for the result is a problem for the control of cervical cancer and must be addressed through educational strategies that reinforce the importance of the return for the early detection of this cancer.

  1. The Prevalence of Human Papilloma Virus (HPV) in Women using Liquid Base Pap Smear in Rasht, Northern of Iran.

    Science.gov (United States)

    Mehran, Seyed Mohamad Mohseni; Ghanaei, Mandana Mansour; Mojtehadi, Ali

    2015-07-01

    HPV is one of the most common sexually transmitted infections. However, little is known about its prevalence in the female population in Rasht, Northern of Iran. The aim of this study was to find the incidences of HPV viruses in high-risk women in Rasht by wet Pap smear from 2010 to 2015. This cross-sectional study investigated HPV prevalence and its genotype distribution among 103 apparently healthy and non- healthy women with abnormal cells in pap exam. DNA samples were extracted by boiling and phenol - chloroform methods, then used as template for amplifying of specific fragment of HPV genome by PCR using GP5+ / GP6+ primers. PCR products were electrophoresed in 1.5% agarose gel (Roche, Germany) containing Sybrsafe. DNA ladder (Roche Co, Germany) was used to detect the molecular weights of observed bands under UV lamp. Overall, 4/98 women (4.08%) with normal cells and 1/5 women (20%) with abnormal cells were positive for at least one of the high risk HPV types in wet Pap smear. The most HPV infection was found in 26 to 39-year-old individuals. We evidenced a moderate prevalence of HPV infection but needs to be given more attention because in apparently healthy women also, HPV infection was observed. Health officials should conduct the study and wider screening of this infection occurring in this province. Screening for this infection must be recommended in this region.

  2. Impact of HPV testing, HPV vaccine development, and changing screening frequency on national Pap test volume: projections from the National Health Interview Survey (NHIS).

    Science.gov (United States)

    Eltoum, Isam A; Roberson, Janie

    2007-02-25

    The frequently cited number of 50 million annual Papanicolaou cervical screening (Pap) tests performed in the US was based on the National Health Interview Survey (NHIS) of the 1980s. Since then, monumental changes have occurred. More change will soon follow when primary human papilloma virus (HPV) testing and/or HPV vaccine delivery are fully accepted and implemented. The objectives of this study were 1) to estimate the total annual Pap tests performed in the US based on recent NHIS surveys, and 2) to estimate the potential change in the total annual Pap volume produced by changing demographics, reduced screening frequency, HPV testing, and the HPV vaccine. In the NHIS 2000 and NHIS 2005, women were asked to report the frequency of their Pap tests for the 6 years prior to the interview and to report whether they had abnormal findings. The authors analyzed the survey respondents answers to these questions by using SAS Survey Procedures (SAS Institute, NC). The results were stratified by age, and the total national volume was then extrapolated from a similarly stratified 2000 US census. The projected increase of total Pap tests for the next 25 years was determined by using the projected census data. Potential reductions of Pap tests performed secondarily to HPV testing of women >30 years old and of HPV vaccination were also determined. Based on NHIS 2000 and NHIS 2005, 66 million (95% CI, 65-68) and 65 million (95% CI, 64-67) Pap tests were performed in the US, respectively. Had HPV testing been performed in women older than 30 years who had both negative HPV and negative 3-year Pap tests, then 30% (95% CI, 29-32%) of Pap tests would not have been performed. If both HPV testing and vaccination are performed, the total number of Pap tests performed annually is predicted to be reduced by 43% (95% CI, 35-38%). Therefore, despite an expected increase in the population of women eligible for Pap tests, the total number will likely decrease substantially in the future

  3. Self-reported history of Pap-smear in HIV-positive women in Northern Italy: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Ghinelli Florio

    2010-06-01

    Full Text Available Abstract Background The incidence of invasive cervical cancer in HIV-positive women is higher than in the general population. There is evidence that HIV-positive women do not participate sufficiently in cervical cancer screening in Italy, where cervical cancer is more than 10-fold higher in women with AIDS than in the general population. The aim of the present study was to evaluate the history of Pap-smear in HIV-positive women in Italy in recent years. We also examined the sociodemographic, clinical, and organizational factors associated with adherence to cervical cancer screening. Methods A cross-sectional study was conducted between July 2006 and June 2007 in Emilia-Romagna region (Northern Italy. All HIV-positive women who received a follow-up visit in one of the 10 regional infectivology units were invited to participate. History of Pap-smear, including abnormal smears and subsequent treatment, was investigated through a self-administered anonymous questionnaire. The association between lack of Pap-smear in the year preceding the interview and selected characteristics was assessed by means of odds ratios (OR and 95% confidence intervals adjusted for study centre and age. Results A total of 1,002 HIV-positive women were interviewed. Nine percent reported no history of Pap-smear, and 39% had no Pap-smear in the year prior to the date of questionnaire (last year. The lack of Pap-smear in the last year was significantly associated with age Three hundred five (34% women reported a previous abnormal Pap-smear, and of the 178 (58% referred for treatment, 97% complied. Conclusions In recent years the self-reported history of Pap-smear in HIV-positive women, in some public clinics in Italy, is higher than previously reported, but further efforts are required to make sure cervical cancer screening is accessible to all HIV-positive women.

  4. The Effect of an Educational Program Based on Protection Motivation Theory on Pap Smear Screening Behavior among Women Referring to Health Centers in Fasa

    OpenAIRE

    Zahra Khiyali; Leila Ghahremani; Mohammad Hossein Kaveh; Sareh Keshavarzi

    2017-01-01

    Background and Objectives: Despite the importance of pap smear in reducing the incidence of cervical cancer and its death, this cancer is still one of the leading causes of death among women around the world. Accordingly, in this study, we aimed to determine the effect of an educational program based on the protection motivation theory on Pap smear screening behavior. Materials and Methods: This quasi-experimental study was conducted on 200 women referring to Fasa health centers, Fasa, Ira...

  5. Progression and regression of cervical pap test lesions in an urban AIDS clinic in the combined antiretroviral therapy era: a longitudinal, retrospective study.

    Science.gov (United States)

    Lofgren, Sarah M; Tadros, Talaat; Herring-Bailey, Gina; Birdsong, George; Mosunjac, Marina; Flowers, Lisa; Nguyen, Minh Ly

    2015-05-01

    Our objective was to evaluate the progression and regression of cervical dysplasia in human immunodeficiency virus (HIV)-positive women during the late antiretroviral era. Risk factors as well as outcomes after treatment of cancerous or precancerous lesions were examined. This is a longitudinal retrospective review of cervical Pap tests performed on HIV-infected women with an intact cervix between 2004 and 2011. Subjects needed over two Pap tests for at least 2 years of follow-up. Progression was defined as those who developed a squamous intraepithelial lesion (SIL), atypical glandular cells (AGC), had low-grade SIL (LSIL) followed by atypical squamous cells-cannot exclude high-grade SIL (ASC-H) or high-grade SIL (HSIL), or cancer. Regression was defined as an initial SIL with two or more subsequent normal Pap tests. Persistence was defined as having an SIL without progression or regression. High-risk human papillomavirus (HPV) testing started in 2006 on atypical squamous cells of undetermined significance (ASCUS) Pap tests. AGC at enrollment were excluded from progression analysis. Of 1,445 screened, 383 patients had over two Pap tests for a 2-year period. Of those, 309 had an intact cervix. The median age was 40 years and CD4+ cell count was 277 cells/mL. Four had AGC at enrollment. A quarter had persistently normal Pap tests, 64 (31%) regressed, and 50 (24%) progressed. Four developed cancer. The only risk factor associated with progression was CD4 count. In those with treated lesions, 24 (59%) had negative Pap tests at the end of follow-up. More studies are needed to evaluate follow-up strategies of LSIL patients, potentially combined with HPV testing. Guidelines for HIV-seropositive women who are in care, have improved CD4, and have persistently negative Pap tests could likely lengthen the follow-up interval.

  6. The role of compliance with PAP use on blood pressure in patients with obstructive sleep apnea: is longer use a key-factor?

    Science.gov (United States)

    Bouloukaki, I; Mermigkis, C; Tzanakis, N; Giannadaki, K; Mauroudi, E; Moniaki, V; Kallergis, E M; Schiza, S E

    2017-02-01

    Scientific data about the effects of positive airway pressure (PAP) treatment on blood pressure (BP) control are continuously increasing; however, they are controversial. We aimed to determine the long-term effects of compliance with PAP therapy on BP in both hypertensive and normotensive patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). One thousand one hundred sixty eight consecutive patients with newly diagnosed OSAHS, who had been recommended PAP therapy, were followed up for a minimum of 2 years. Patients with previous cardiovascular disease were excluded. BP was measured at baseline and after 2 years of PAP treatment. In addition, the correlation between the changes in BP with different levels of PAP compliance was assessed. At the end of the follow-up period, in the hypertensive group of patients (n=586), a significant decrease was shown in systolic (-11.2 mm Hg, P<0.001) and diastolic BP (-4.2 mm Hg, P<0.001). Furthermore, in the patients without hypertension (n=528), a significant decrease was noted both in systolic and diastolic BP (-3.6, P<0.001 and -2.4, P<0.001, respectively). A correlation between the magnitude of change in systolic and diastolic BP and hours of use of PAP (r=0.14, P=0.002 and r=0.1, P=0.025, respectively) was observed in all patients. Long-term use of PAP treatment, as well as increased hours of PAP in patients with OSAHS use showed significant reductions in BP not only in patients with hypertension, but also in normotensive patients. Therefore a significant potential reduction in cardiovascular mortality and morbidity should be expected in these patients.

  7. A survey of awareness of Pap smear and cervical cancer vaccine among women at tertiary care centre in Eastern Uttar Pradesh India

    OpenAIRE

    Anjali Rani; Kalpana Singh; Shreya Thapa

    2015-01-01

    Background: Cervical cancer is very common in developing countries. In Uttar Pradesh the literacy rate of women is low as compared to other states of India. Poverty is very high. Most women report with advance stage of cervical cancer. It can be prevented by early screening with Pap smear. Aim of our study is to know about the awareness of Pap smear and cervical cancer vaccine among women attending a tertiary hospital in Eastern part of Uttar Pradesh India. Methods: A questionnaire based ...

  8. A Peptide Derived from the HIV-1 gp120 Coreceptor-Binding Region Promotes Formation of PAP248-286 Amyloid Fibrils to Enhance HIV-1 Infection.

    Directory of Open Access Journals (Sweden)

    Jinquan Chen

    Full Text Available Semen is a major vehicle for HIV transmission. Prostatic acid phosphatase (PAP fragments, such as PAP248-286, in human semen can form amyloid fibrils to enhance HIV infection. Other endogenous or exogenous factors present during sexual intercourse have also been reported to promote the formation of seminal amyloid fibrils.Here, we demonstrated that a synthetic 15-residue peptide derived from the HIV-1 gp120 coreceptor-binding region, designated enhancing peptide 2 (EP2, can rapidly self-assemble into nanofibers. These EP2-derivated nanofibers promptly accelerated the formation of semen amyloid fibrils by PAP248-286, as shown by Thioflavin T (ThT and Congo red assays. The amyloid fibrils presented similar morphology, assessed via transmission electron microscopy (TEM, in the presence or absence of EP2. Circular dichroism (CD spectroscopy revealed that EP2 accelerates PAP248-286 amyloid fibril formation by promoting the structural transition of PAP248-286 from a random coil into a cross-β-sheet. Newly formed semen amyloid fibrils effectively enhanced HIV-1 infection in TZM-bl cells and U87 cells by promoting the binding of HIV-1 virions to target cells.Nanofibers composed of EP2 promote the formation of PAP248-286 amyloid fibrils and enhance HIV-1 infection.

  9. Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids

    Energy Technology Data Exchange (ETDEWEB)

    Touchette, Megan H.; Bommineni, Gopal R.; Delle Bovi, Richard J.; Gadbery, John; Nicora, Carrie D.; Shukla, Anil K.; Kyle, Jennifer E.; Metz, Thomas O.; Martin, Dwight W.; Sampson, Nicole S.; Miller, W. T.; Tonge, Peter J.; Seeliger, Jessica C.

    2015-09-08

    Although classified as Gram-positive bacteria, Corynebacterineae possess an asymmetric outer membrane that imparts structural and thereby physiological similarity to more distantly related Gram-negative bacteria. Like lipopolysaccharide in Gram-negative bacteria, lipids in the outer membrane of Corynebacterineae have been associated with the virulence of pathogenic species such as Mycobacterium tuberculosis (Mtb). For example, Mtb strains that lack long, branched-chain alkyl esters known as dimycocerosates (DIMs) are significantly attenuated in model infections. The resultant interest in the biosynthetic pathway of these unusual virulence factors has led to the elucidation of many of the steps leading to the final esterification of the alkyl beta-diol, phthiocerol, with branched-chain fatty acids know as mycocerosates. PapA5 is an acyltransferase implicated in these final reactions. We here show that PapA5 is indeed the terminal enzyme in DIM biosynthesis by demonstrating its dual esterification activity and chain-length preference using synthetic alkyl beta-diol substrate analogues. Applying these analogues to a series of PapA5 mutants, we also revise a model for the substrate binding within PapA5. Finally, we demonstrate that the Mtb Ser/Thr kinase PknB modifies PapA5 on three Thr residues, including two (T196, T198) located on an unresolved loop. These results clarify the DIM biosynthetic pathway and suggest possible mechanisms by which DIM biosynthesis may be regulated by the post-translational modification of PapA5.

  10. The health beliefs of mothers about preventing cervical cancer and their intention to recommend the Pap test to their daughters: a cross-sectional survey

    Directory of Open Access Journals (Sweden)

    Hae Won Kim

    2016-05-01

    Full Text Available Abstract Background Mothers have a primary role in the prevention of cervical cancer in Korea. This study aimed to determine the awareness and health beliefs of mothers about preventing cervical cancer in their daughters, their intention to recommend the Pap test to their daughters, and the factors influencing this intention. Methods A cross-sectional survey design was employed, and the study enrolled mothers (n = 1,581 of pubescent girls aged 13 to 18 years who were living nationwide in Korea. The six health-beliefs variables related to preventing cervical cancer in their daughters, awareness of the importance of cervical cancer prevention methods, and the intention to recommend the Pap test to daughters were investigated. The impacts of these health beliefs of the mothers and the sociodemographic factors influencing their intention to recommend the Pap test to their daughters were assessed using multiple logistic regression analysis. Results Almost one-quarter (23.7 % of the mothers had talked about the Pap test, 69.2 % were intending to recommend the Pap test to their daughters, and 38.5 % considered that the Pap test could be necessary if their daughters became sexually active. The significant health beliefs influencing the intention to recommend the Pap test were the perceived barriers [odds ratio (OR = 1.47, 95 % confidence interval (95 % CI = 1.03–2.11] and benefits (OR = 2.25, 95 % CI = 1.55–3.25. The significant sociodemographic factors of mothers were their education (OR = 1.52, 95 % CI = 1.08–2.13, their experience of talking about the Pap test with their daughters (OR = 2.11, 95 % CI = 1.23–3.64, their regularity of undergoing the Pap test themselves (OR = 1.98, 95 % CI = 1.30–3.03, and their age when they first underwent the Pap test (OR = 1.60, 95 % CI = 1.43–0.82. Conclusions The mothers perceived HPV vaccination as the most important of the five methods

  11. Potential application of electronic nose in processed animal proteins (PAP detection in feedstuffs

    Directory of Open Access Journals (Sweden)

    Dell'Orto V.

    2004-01-01

    Full Text Available Electronic nose and olfactometry techniques represent a modern analytical approach in food industry since they could potentially improve quality and safety of food processing. The aim of this study was to evaluate possible application of electronic nose in PA P detection and recognition in feed. For this purpose 6 reference feedstuffs (CRA-W / UE STRAT F E E D Project were used. The basis of the test samples was a compound feed for bovine fortified with processed animal proteins ( PAP consisting of meat and bone meal (MBM and/or fish meal at different concentrations. Each feed sample was tested in glass vials and the odour profile was determined by the ten MOS (metal oxide semi-conductor sensors of the electronic nose. Ten different descriptors, representing each ten sensors of electronic nose, were used to characterise the odour of each sample. In the present study, electronic nose was able to discriminate the blank sample from all other samples containing PA P ( M B M , fish meal or both. Samples containing either 0.5% of MBM or 5% of fish meal were identified, while samples containing a high fish meal content (5% associated with a low MBM content (0.5% were not discriminated from samples containing solely fish meal at that same high level (5%. This latter indicates that probably the high fish meal level, in samples containing both MBM and fish meal, tended to mask MBM odour. It was also evident that two odour descriptors were enough to explain 72.12% of total variability in odour pattern. In view of these results, it could be suggested that electronic nose and olfactometry techniques can provide an interesting approach for screening raw materials in feed industry, even though further studies using a wider set of samples are needed.

  12. [Sexual risk behaviours and PAP testing in university women vaccinated against human papillomavirus].

    Science.gov (United States)

    Fernández-Feito, Ana; Antón-Fernández, Raquel; Paz-Zulueta, María

    2018-05-01

    To estimate the association between the human papillomavirus (HPV) vaccine and sexual risk behaviour, as well as the participation in the Cervical Cancer Screening Program (CCSP). Cross-sectional study. School of Medicine and Health Sciences, School of Law, and School of Economics and Business (University of Oviedo). Female university students. Information was collected about contraceptive methods, sexual behaviours, HPV knowledge, and participation in the CCSP. Furthermore, proportions and odds ratio (OR) were estimated with their corresponding 95% confidence intervals (95%CI). Approximately two-thirds (67.7%) of the sample was vaccinated against HPV, and 216 women (65.3%) were sexually active. Barrier contraceptive methods were used by 67.6% during their current intimate relationships, being less frequent in non-vaccinated women (54.9% vs. 75.4% in vaccinated female students) (P=.002). The risk of having at least one sexual risk behaviour was higher in non-vaccinated women: OR2.29 (95%CI: 1.29-4.07). In addition, the probability of having a PAP test within the CCSP was higher in non-vaccinated women: OR2.18 (95%CI: 1.07-4.47). The prevalence of sexual risk behaviours in non-vaccinated women is elevated, and it is related to the lack of use of barrier contraceptive methods. The vaccination against HPV could affect sexual behaviours and the participation in the CCSP. Therefore, the information received by young people about contraceptive methods, sexually transmitted diseases, and cancer prevention should be reinforced. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  13. Legislation framework for Croatian renewable energy sources development

    Directory of Open Access Journals (Sweden)

    Raguzin Igor

    2007-01-01

    Full Text Available The energy sector reform in the Republic of Croatia (started 2001, which comprises restructuring, liberalization, privatization, and changes in the overall energy sector, has a significant effect on the possibilities of introducing and increasing the share of renewable energy sources (RES. The adoption of a new legislative framework within the context of reforming Croatia’s energy sector is of key importance for further development and for the future or RES utilization. The Electricity Market Act sets out the le- gal obligation to purchase electricity produced from RES in the manner that a quota or a minimum obligatory share of RES in electricity production is determined by a Government ordinance combined with Tariff system for the production of electricity from renewable energy sources and co-generation. Consequently, on the one hand, incentive funds needed to cover increased costs of production from RES will be collected from customers through the supplier and distributed to privileged producers (feed-in-tariffs, purchase is guaranteed to RES producers on known terms through the Market Opera- tor. On the other hand, RES investment projects will be encouraged by pur- pose-specific government subsidy and by the Environmental Protection and Energy Efficiency Fund (out of public budget. By applying new energy legislation and associated by-laws (coming into force in 2007, RES projects in Croatia will be provided with a complete and stable legal framework as well as support through incentive measures which will equitably value environmental, social and other benefits of RES use.

  14. Tesis doctorales 2012-2013 : Serie resúmenes

    OpenAIRE

    Di Gregori, María Cristina

    2014-01-01

    En continuidad con la publicación de Serie Resúmenes, Tesis Doctorales, la Universidad Nacional de La Plata presenta un nuevo libro que contiene información sobre las tesis defendidas y aprobadas correspondiente a los doctores titulados en el período 2012-2013. Como señalarámos en nuestro volumen inaugural, esta publicación se inscribe en el marco de la revalorización que sostiene nuestra institución respecto del valor de la comunicación y difusión del conocimiento; en este caso, la producció...

  15. Resúmenes de los trabajos sobre las Enfermedades Neuromusculares

    OpenAIRE

    Congreso Nacional de Neurología

    2010-01-01

    Las enfermedades neuromusculares constituyen un conjunto de afectaciones que afectan las neuronas motoras periférica, las vías motoras eferentes o los efectores (músculos esqueléticos). Sus manifestaciones clínicas son muy variadas y dependen de la causa y de los niveles de afectación. En este acápite se pueden encontrar los resúmenes de trabajos relacionados con el síndrome de Guillain Barre, polineuropatía diabética, Atrofia Muscular Espinal, Distrofia miotónica y otros todos presentados en...

  16. Making cities energy efficient. Urban and regional planning adopting RES

    Energy Technology Data Exchange (ETDEWEB)

    Ahonen, A.-M.; David, T.; Dorfner, J. [and others

    2013-06-01

    This report summarises the outcomes of a 30 months duration continuing education project entitled 'Urban Planners with Renewable Energy Skills' (UP-RES). The project was carried out by a multi-disciplinary international consortium with the aim of informing planners and related professionals about energy-efficient and CO{sub 2} reducing technologies, practices and systems that can be developed across urban areas to serve whole communities. This report provides an overview of the key issues: The overall project approach to devising a training program based on preceding training needs analysis The key tasks involved in creating the training materials The marketing of the training as well as evaluation results Best practise examples of RES in urban planning. The UP-RES project has focused on several major target groups. These include those groups directly involved in taking forward renewable energy projects for whom the UP-RES training was principally focused; those who wish to deliver such training programmes; and policy makers who are ultimately responsible for the decisions that govern how widely such technologies will be implemented. Each of these groups has its own perspective concerning renewable energy technologies so the report is structured accordingly: For professionals involved in implementation: Among those professions that are likely to become involved with renewable energy initiatives in urban areas are urban planners, architects, energy suppliers, developers, building owners, and consulting engineers. For these professionals chapters 3.2 (summary of training need analysis) and 4 (best practise examples) are most likely to appeal. For training experts and organisations: Training programmes that address the relevance of renewable energies in urban areas require a comprehensive set of materials. As an example of how to organise training courses and lessons learnt, chapter 3 might be interesting. For the generally interested: Renewable energies are

  17. Recherche de marqueurs lipidiques aptes à montrer l’absence de tissus nerveux dans les matières premières des gélatines d’os

    Directory of Open Access Journals (Sweden)

    Combe Nicole

    2002-09-01

    Full Text Available La gélatine est fabriquée à partir de deux catégories de matières premières, dénommées « os lourds » et « os légers », obtenues après dégraissage, séchage, broyage, puis tamisage d’os frais de bœuf, à l’exclusion de matériaux à risques vis-à-vis de l’encéphalopathie spongiforme bovine (cerveaux, yeux, amygdales et moelle épinière. L’objectif de cette étude était d’identifier un ou plusieurs constituants lipidiques spécifiques des tissus nerveux, et principalement de la moelle épinière, permettant de vérifier l’absence de tissus nerveux dans les matières premières utilisées pour la fabrication de gélatine. Pour cela, la composition lipidique de la moelle épinière a été comparée à celle des matières premières de gélatine. La pertinence d’un paramètre (p, vis-à-vis d’une source donnée, a été évaluée par la valeur du facteur : F (p = [p]moelle épinière/[p] OS, qui est le rapport entre sa concentration dans les lipides de moelle épinière et celle dans la source osseuse considérée. Plus la valeur de F est élevée, plus le paramètre est pertinent. Trois paramètres ont été ciblés sur la base de leur caractère spécifique des tissus nerveux par rapport aux graisses d’os : (1 les phospholipides (PL; (2 les acides gras à très longues chaînes (AGTLC = 20:0 + 20:1 + 22:0 + 22:1 n-9 + 23:0 + 24:0 + 24:1 n-9 ; (3 les alcools gras, analysés sous la forme de dérivés diméthyl acétals (DMA. Eu égard aux matières premières servant à la fabrication de gélatine, la valeur de FPL varie de 8 à 15, celle de FAGTLC de 25 à 41. La valeur de FDMA est égale à 26 vis-à-vis des « os légers », elle est infiniment grande vis-à-vis des « os lourds » puisque, dans cette matière première, les DMA sont indétectables. Ainsi pour cette catégorie de matière première, le paramètre DMA s’avère le plus adapté pour détecter du matériel d’origine nerveuse (moelle épinière.

  18. A Shandon PapSpin liquid-based gynecological test: A split-sample and direct-to-vial test with histology follow-up study

    Directory of Open Access Journals (Sweden)

    Rimiene J

    2010-01-01

    Full Text Available Background: Studies for liquid-based Papanicolaou (Pap tests reveal that liquid-based cytology (LBC is a safe and effective alternative to the conventional Pap smear. Although there is research on ThinPrep and SurePath systems, information is lacking to evaluate the efficiency and effectiveness of systems based on cytocentrifugation. This study is designed to determine the sensitivity and specificity of the Shandon PapSpin (ThermoShandon, Pittsburgh, Pennsylvania, USA liquid-based gynecological system. We used split-sample and direct-to-vial study design. Materials and Methods: 2,945 women referred to prophylactic check-up were enrolled in this study. Split sample design was used in 1,500 women and residual cervical cytology specimen from all these cases was placed in fluid for PapSpin preparation after performing conventional smear. The direct-to-vial study was carried out in another cohort of 1,445 women in whom the entire cervical material was investigated using only the PapSpin technique. Follow up histological diagnoses for 141 women were obtained from both study arms following 189 abnormal cytology cases. 80 LBC cases from the split sample group and 61 LBC cases in the direct-to-vial group were correlated with the histology results. The sensitivity and secificity of the conventional smear and PapSpin tests in both study arms were compared. Results: In the split sample group, conventional smears showed a higher proportion of ASC-US (atypical cells undetermined significance: 31 (2.1% vs 10 (0.7% in PapSpin (P = 0.001. A higher proportion of unsatisfactory samples was found in the conventional smear group: 25 (1.7% vs 6 (0.4% cases (P = 0.001. In the split sample group, the sensitivity of the conventional and PapSpin tests was 68.7% vs 78.1%, and the specificity 93.8% vs 91.8%, respectively. In the direct to vial group PapSpin sensitivity was 75.9% and specificity 96.5%. The differences in sensitivity and specificity were not significant. The

  19. MitoRes: a resource of nuclear-encoded mitochondrial genes and their products in Metazoa.

    Science.gov (United States)

    Catalano, Domenico; Licciulli, Flavio; Turi, Antonio; Grillo, Giorgio; Saccone, Cecilia; D'Elia, Domenica

    2006-01-24

    Mitochondria are sub-cellular organelles that have a central role in energy production and in other metabolic pathways of all eukaryotic respiring cells. In the last few years, with more and more genomes being sequenced, a huge amount of data has been generated providing an unprecedented opportunity to use the comparative analysis approach in studies of evolution and functional genomics with the aim of shedding light on molecular mechanisms regulating mitochondrial biogenesis and metabolism. In this context, the problem of the optimal extraction of representative datasets of genomic and proteomic data assumes a crucial importance. Specialised resources for nuclear-encoded mitochondria-related proteins already exist; however, no mitochondrial database is currently available with the same features of MitoRes, which is an update of the MitoNuc database extensively modified in its structure, data sources and graphical interface. It contains data on nuclear-encoded mitochondria-related products for any metazoan species for which this type of data is available and also provides comprehensive sequence datasets (gene, transcript and protein) as well as useful tools for their extraction and export. MitoRes http://www2.ba.itb.cnr.it/MitoRes/ consolidates information from publicly external sources and automatically annotates them into a relational database. Additionally, it also clusters proteins on the basis of their sequence similarity and interconnects them with genomic data. The search engine and sequence management tools allow the query/retrieval of the database content and the extraction and export of sequences (gene, transcript, protein) and related sub-sequences (intron, exon, UTR, CDS, signal peptide and gene flanking regions) ready to be used for in silico analysis. The tool we describe here has been developed to support lab scientists and bioinformaticians alike in the characterization of molecular features and evolution of mitochondrial targeting sequences. The

  20. The frequency of having pap-smear tests among women between 15-64 years old and the evaluation of the level of their knowledge

    International Nuclear Information System (INIS)

    Sevil, S.; Kevser, O.; Aleattin, U.

    2013-01-01

    Objective: To determine the frequency of Pap smear testing among women and to evaluate their level of knowledge about the test and other relevant factors. Methods: The study comprised women who presented to the Gynaecology and Obstetrics Polyclinic of Sakarya Training and Research Hospital, Turkey, between April 1 and 30, 2012. The questionnaire was developed in line with the objectives of the study. They were filled by the participants who were supervised during the process. Women who had had at least one Pap smear test in life were considered to have taken a Pap smear test , and those who had heard of the test were accepted as women who k new of the Pap smear test . Data was analysed using SPSS 15.0. Chi-square test was used for analyses, and statistical significance was set at p<0.05. Results: The age of 601 subjects ranged between 15 and 64 years, with a mean of 31.09+-10.49 years. Of the total, 115 (19.1%) had taken a Pap smear test before and 293 (48.8%) knew of the test. The proportion of the women who had had a Pap smear test was higher among those who were over 30 years of age (n=73; 63.47%), had post-high school educational degrees (n=68; 59.13%), had moderate familial income status (n=74; 64.34%), were married (n=109; 94.78%), had first sexual experience after 25 years of age(n=42; 36.52%), and were not using a contraceptive method (n=97; 84.34%) (p<0.05 for each). Besides, more women with previous knowledge of the test had taken the test (p<0.05). Conclusion: The subjects did not have sufficient information on Pap smear and the frequency of having a test was low. Raising awareness would prove beneficial. (author)

  1. Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis.

    Science.gov (United States)

    Carvalho, Rodrigo D; Breyner, Natalia; Menezes-Garcia, Zelia; Rodrigues, Nubia M; Lemos, Luisa; Maioli, Tatiane U; da Gloria Souza, Danielle; Carmona, Denise; de Faria, Ana M C; Langella, Philippe; Chatel, Jean-Marc; Bermúdez-Humarán, Luis G; Figueiredo, Henrique C P; Azevedo, Vasco; de Azevedo, Marcela S

    2017-02-13

    Mucositis is one of the most relevant gastrointestinal inflammatory conditions in humans, generated by the use of chemotherapy drugs, such as 5-fluoracil (5-FU). 5-FU-induced mucositis affects 80% of patients undergoing oncological treatment causing mucosal gut dysfunctions and great discomfort. As current therapy drugs presents limitations in alleviating mucositis symptoms, alternative strategies are being pursued. Recent studies have shown that the antimicrobial pancreatitis-associated protein (PAP) has a protective role in intestinal inflammatory processes. Indeed, it was demonstrated that a recombinant strain of Lactococcus lactis expressing human PAP (LL-PAP) could prevent and improve murine DNBS-induced colitis, an inflammatory bowel disease (IBD) that causes severe inflammation of the colon. Hence, in this study we sought to evaluate the protective effects of LL-PAP on 5-FU-induced experimental mucositis in BALB/c mice as a novel approach to treat the disease. Our results show that non-recombinant L. lactis NZ9000 have antagonistic activity, in vitro, against the enteroinvasive gastrointestinal pathogen L. monocytogenes and confirmed PAP inhibitory effect against Opportunistic E. faecalis. Moreover, L. lactis was able to prevent histological damage, reduce neutrophil and eosinophil infiltration and secretory Immunoglobulin-A in mice injected with 5-FU. Recombinant lactococci carrying antimicrobial PAP did not improve those markers of inflammation, although its expression was associated with villous architecture preservation and increased secretory granules density inside Paneth cells in response to 5-FU inflammation. We have demonstrated for the first time that L. lactis NZ9000 by itself, is able to prevent 5-FU-induced intestinal inflammation in BALB/c mice. Moreover, PAP delivered by recombinant L. lactis strain showed additional protective effects in mice epithelium, revealing to be a promising strategy to treat intestinal mucositis.

  2. OPTIMASI KLASIFIKASI SEL TUNGGAL PAP SMEAR MENGGUNAKAN CORRELATION BASED FEATURES SELECTION (CFS BERBASIS C4.5 DAN NAIVE BAYES

    Directory of Open Access Journals (Sweden)

    Asti Herliana

    2016-11-01

    Full Text Available Abstract – Cervical cancer was the most dangerous disease and generally attacks women. Early detection through Pap Smear method was one way to prevent the desease to grow in womans cervival canal. Based on the result of Pap Smear methode, the single cell of data that known as herlev data is available. This data, then used as a reference by the experts to find the best level classification from each class of cervical cancer. The decision tree C4.5 and Naïve Bayes have proven to give the best result on 280 data trial of herlev with support by Correlation based Features Selection (CFS optimization method. The issues raised in the present study was does CFS optimization methode that combined with the classification method of C4.5 and Naïve Bayes can provide increased the accuracy results when it faced the 917 data of herlev. The results of this study show that CFS method that combined either with C4.5 methods and naïve bayes classification accuracy was decrease when compared without using CFS method. In terms of showing that CFS can not provide the best result when if confronted with big data. Keywords : optimization, classification, single cell of Pap Smear, Correlation based Features Selection, C4.5, Naïve Bayes   Abstrak – Kanker serviks merupakan penyakit yang sangat berbahaya dan pada umumnya menyerang kaum wanita. Deteksi sejak dini melalui metode Pap Smear merupakan salah satu cara untuk mencegah penyakit ini berkembang didalam saluran serviks wanita. Berdasarkan hasil dari metode Pap Smear, didapatkanlah data sel tunggal yang kini dikenal dengan data herlev. Data ini, kemudian dijadikan acuan dalam penelitian oleh para ahli dewasa ini untuk menemukan tingkat klasifikasi terbaik dari masing-masing kelas kanker serviks. Metode Decision tree C4.5 dan Naïve Bayes terbukti memberikan hasil yang terbaik pada ujicoba data herlev sebanyak 280 data dengan dukungan dari metode optimasi Correlation based Features Selection(CFS. Permasalahan

  3. Écuyères and "doing gender"

    DEFF Research Database (Denmark)

    Hedenborg, Susanna; Pfister, Gertrud Ursula

    2012-01-01

    masculinity and horsemanship conveys the impression that women had nothing to do with horses. This is true for many situations. The circus arena, however, seems to have been an exception as women could perform there. At the heart of the performances was not only equestrianism, but also the notion of gender......The purpose of this article is to analyse gender relations in equestrianism from the beginning of the 19th to the first decades of the 20th century. Focus will be on the female horse riding circus artists, the écuyères. The fact that women were circus riders at this time is interesting as in many....... It is even likely that ”doing gender” was an indispensable part of the show, as the allure of the écuyères depended on the embodiment and presentation of seemingly incompatible features: beauty, grace and femininity as well as mastery of an art that was a traditionally male domain....

  4. EmployRES. The impact of renewable energy policy on economic growth and employment in the European Union. Final report

    International Nuclear Information System (INIS)

    Ragwitz, M.; Schade, W.; Breitschopf, B.; Walz, R.; Helfrich, N.; Rathmann, M.; Resch, G.; Panzer, C.; Faber, T.; Haas, R.; Nathani, C.; Holzhey, M.; Konstantinaviciute, I.; Zagame, P.; Fougeyrollas, A.; Le Hir, B.

    2009-04-01

    This study aims to meet the need for scientifically robust information on the gross effects (direct and indirect) as well as on the net effects (including both conventional replacement and budget effects) of renewable energy policies in Europe. Furthermore, the future development of RES in Europe will take place against the background of a global market for RES technology. This global market and the potential share of European industries in it will play a critical role in the potentials for growth and employment. This study aims to provide a sound scientific analysis of these issues. This report is divided into four main parts, A, B, C and D. While the first three covers the introduction, the theoretical approach, the modelling steps and structure of the report, the fourth part, part D, discusses in detail the models and results of the projects. It begins with chapter D 1 which describes past RES deployment and its costs. Then follows the past macroeconomic impacts presented by gross effects on employment and value added (D 2). Thereafter, the future potential (D 3) and future deployment (D 4) of renewable energy sources (RES) are discussed. Before the presentation of the future gross and net effects, the five scenarios used in the macro-economic models (D 5) are explained in detail. Finally we depict the future gross and net impacts on employment and GDP in D 6 and D 7, respectively. The comparison between the results of the two models and our conclusion for the study follows in chapter D 8 and 9

  5. Funding source and primary outcome changes in clinical trials registered on ClinicalTrials.gov are associated with the reporting of a statistically significant primary outcome: a cross-sectional study [v2; ref status: indexed, http://f1000r.es/5bj

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    Sreeram V Ramagopalan

    2015-04-01

    Full Text Available Background: We and others have shown a significant proportion of interventional trials registered on ClinicalTrials.gov have their primary outcomes altered after the listed study start and completion dates. The objectives of this study were to investigate whether changes made to primary outcomes are associated with the likelihood of reporting a statistically significant primary outcome on ClinicalTrials.gov. Methods: A cross-sectional analysis of all interventional clinical trials registered on ClinicalTrials.gov as of 20 November 2014 was performed. The main outcome was any change made to the initially listed primary outcome and the time of the change in relation to the trial start and end date. Findings: 13,238 completed interventional trials were registered with ClinicalTrials.gov that also had study results posted on the website. 2555 (19.3% had one or more statistically significant primary outcomes. Statistical analysis showed that registration year, funding source and primary outcome change after trial completion were associated with reporting a statistically significant primary outcome. Conclusions: Funding source and primary outcome change after trial completion are associated with a statistically significant primary outcome report on clinicaltrials.gov.

  6. One year of Seaglider dissolved oxygen concentration profiles at the PAP site

    Science.gov (United States)

    Binetti, Umberto; Kaiser, Jan; Heywood, Karen; Damerell, Gillian; Rumyantseva, Anna

    2015-04-01

    Oxygen is one of the most important variables measured in oceanography, influenced both by physical and biological factors. During the OSMOSIS project, 7 Seagliders were used in 3 subsequent missions to measure a multidisciplinary suite of parameters at high frequency in the top 1000 m of the water column for one year, from September 2012 to September 2013. The gliders were deployed at the PAP time series station (nominally at 49° N 16.5° W) and surveyed the area following a butterfly-shaped path. Oxygen concentration was measured by Aanderaa optodes and calibrated using ship CTD O2 profiles during 5 deployment and recovery cruises, which were in turn calibrated by Winkler titration of discrete samples. The oxygen-rich mixed layer deepens in fall and winter and gets richer in oxygen when the temperature decreases. The spring bloom did not happen as expected, but instead the presence of a series of small blooms was measured throughout spring and early summer. During the summer the mixed layer become very shallow and oxygen concentrations decreased. A Deep Oxygen Maximum (DOM) developed along with a deep chlorophyll maximum during the summer and was located just below the mixed layer . At this depth, phytoplankton had favourable light and nutrient conditions to grow and produce oxygen, which was not subject to immediate outgassing. The oxygen concentration in the DOM was not constant, but decreased, then increased again until the end of the mission. Intrusions of oxygen rich water are also visible throughout the mission. These are probably due to mesoscale events through the horizontal transport of oxygen and/or nutrients that can enhance productivity, particularly at the edge of the fronts. We calculate net community production (NCP) by analysing the variation in oxygen with time. Two methods have been proposed. The classical oxygen budget method assumes that changes in oxygen are due to the sum of air-sea flux, isopycnal advection, diapycnal mixing and NCP. ERA

  7. Motivaciones de la expresión metafórica venezolana. El papá de los helados

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    MAIKEL RAMÍREZ ÁLVAREZ

    2016-01-01

    Full Text Available El objetivo de esta investigación fue explicar las motivaciones de la expresión metafórica del habla cotidiana venezolana “el papá de los helados”. Teóricamente, se sustenta en Cuenca y Hilferty (1999, Johnson (2006, Díaz (2006, Lakoff y Johnson (2009 y Kövecses (2010. En cuanto a la metodología, es una investigación descriptiva e interpretativa. Los resultados son los siguientes: (a la imagen esquemática de la metáfora conceptual EL PODER ES ARRIBA se proyecta sobre la imagen esquemática de un helado en virtud de su verticalidad y acumulación hacia arriba; (b se recurre al helado, además, dado que lo dulce metaforiza a lo sublime; (c el dominio del padre se emplea, debido a que es el miembro que encabeza una familia, la autoridad simbólica; (d la imagen esquemática de el papá de los helados, a saber, el helado más grande de todos se proyecta sobre un hombre que destaque en determinado aspecto. En conclusión, la expresión metafórica “el papá de los helados” es motivada por un conjunto complejo de metáforas primarias, imágenes esquemáticas y metáforas cotidianas que surgen de las experiencias concretas y corrientes de los individuos, para designar a un hombre con poder sobre otros en algún aspecto de la vida diaria.

  8. Spatio-temporal changes in the distribution of phytopigments and phytoplanktonic groups at the Porcupine Abyssal Plain (PAP) site

    Science.gov (United States)

    Smythe-Wright, Denise; Boswell, Stephen; Kim, Young-Nam; Kemp, Alan

    2010-08-01

    We have made a comprehensive study of pigment distributions and microscopically determined phytoplankton abundances within the Porcupine Abyssal Plain (PAP) location in the North Atlantic to better understand phytoplankton variability, and make some suggestions regarding the composition of the material falling to the sea bed and its impacts on benthic organisms such as Amperima rosea. The area has been the focus of many studies of ocean fluxes and benthic communities over recent years, but little attention has been given to the spatio-temporal variability in the surface waters. Dawn casts over a 12-day period at the PAP mooring site (48.83°N 16.5°W) revealed the presence of only one species, the diatom Actinocyclus exiguus, at bloom concentrations for just 5 days. Smaller populations of other diatoms and the dinoflagellates Gymnodinium and Gyrodinium were also present at this time. Following this 5-day interval, a mixed population of small-sized dinoflagellates, prymnesiophytes, prasinophytes, chrysophytes and cyanobacteria occurred. It is clear from concomitant CTD/bottle surveys that rapid changes in phytoplankton community structure at a fixed time series position do not necessarily reflect a degradation or manifestation of one particular species but rather represent the movement of eddies and other water masses within very short timescales. These cause substantial variability in the species class and size fraction that may explain the variability in carbon export that has been seen at the PAP site. We also make some suggestions on the variable composition of the material falling to the seabed and its impact on benthic organisms such as Amperima rosea.

  9. Comparison of HFNC, bubble CPAP and SiPAP on aerosol delivery in neonates: An in-vitro study.

    Science.gov (United States)

    Sunbul, Fatemah S; Fink, James B; Harwood, Robert; Sheard, Meryl M; Zimmerman, Ralph D; Ari, Arzu

    2015-11-01

    Aerosol drug delivery via high flow nasal cannula (HFNC), bubble continuous positive airway pressure (CPAP), and synchronized inspiratory positive airway pressure (SiPAP) has not been quantified in spontaneously breathing premature infants. The purpose of this study was to compare aerosol delivery via HFNC, bubble CPAP, and SiPAP in a model of a simulated spontaneously breathing preterm infant. The types of CPAP systems and nebulizer positions used during aerosol therapy will impact aerosol deposition in simulated spontaneously breathing infants. Quantitative, comparative, in-vitro study. A breath simulator was set to preterm infant settings (VT : 9 ml, RR: 50 bpm and Ti: 0.5 sec) and connected to the trachea of an anatomical upper airway model of a preterm infant via collecting filter distal to the trachea. The HFNC (Optiflow; Fisher & Paykel), Bubble CPAP (Fisher & Paykel), and SiPAP (Carefusion) were attached to the nares of the model via each device's proprietary nasal cannula and set to deliver a baseline of 5 cm H2 O pressure. Albuterol sulfate (2.5 mg/0.5 ml) was aerosolized with a mesh nebulizer (Aeroneb Solo) positioned(1) proximal to the patient and(2) prior to the humidifier (n = 5). The drug was eluted from the filter with 0.1 N HCl and analyzed via spectrophotometry (276 nm). Data were analyzed using descriptive statistics, t-tests, and one-way analysis of variance (ANOVA), with P CPAP (1.24 ± 0.24; p = 0.008). Placement of the nebulizer prior to the humidifier increased deposition with all devices (P < 0.05). Aerosol can be delivered via all three devices used in this study. Device selection and nebulizer position impacted aerosol delivery in this simulated model of a spontaneously breathing preterm infant. © 2014 Wiley Periodicals, Inc.

  10. Prevalence of human papilloma virus in cervical smear by DNA PCR testing and its comparison with pap smear

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    Sushil Kumar

    2013-01-01

    Discussion: The study reveals HPV prevalence rate of 28.3% in women attending gynaecology OPD of a tertiary care hospital and also prevalence of HPV was found to be highest in sexually active individuals with parity of 3 or more. These results are in agreement to many published national and international studies [12,13,14]. The study results also indicate lower sensitivity and higher specificity of Pap smear in detecting HPV infection, however it still remains the most important practicably available test in early detection of cervical carcinoma.

  11. Relations entre les types de dépôts évaporitiques et la présence de couches riches en matière organique (roches-mères potentielles Relationship Between Different Types of Evaporitic Deposits and the Occurrence of Organic-Rich Layers (Potential Source Rocks

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    Busson G.

    2006-11-01

    Full Text Available La fertilité exceptionnelle des eaux salées est confirmée par des études récentes sur l'Actuel (marais salants de Méditerranée occidentale. Le benthos est représenté par des mollusques, foraminifères, ostracodes et surtout des cyanophycées et des populations bactériennes ; le plancton par le microphytoplancton (Dunaliella, diatomées, etc, par le zooplancton (flagellés, Arternia salina et par de très nombreuses bactéries hétérotrophes. Si les espèces sont d'autant plus rares que la salinité est élevée, la prolifération des formes adaptées peut atteindre des valeurs supérieures à celles réalisées dans la plupart des autres milieux. On rappelle ensuite l'efficacité des systèmes d'eaux stratifiées pour la conservation de la matière organique originellement élaborée dans l'eau photique et oxygénée. Ces systèmes peuvent s'accompagner de proliférations bactériennes photosynthétiques exposées à des mortalités en masse pouvant être responsables de véritables lamines organiques. Dans les évaporites de plates-formes où la ségrégation des salinités et des dépôts a été synchrone et latérale, la tranche d'eau a dû être faible et, de ce fait, peu favorable à l'établissement de systèmes d'eaux stratifiées et surtout à leur pérennité géologique. Ces accumulations s'avèrent donc en général pauvres en matière organique, de même qu'elles ne s'accompagnent pas d'appareils récifaux abondants. Dans les évaporites de centre de cuvette, les dépôts sont imputables à une succession de phases de salinité croissante dans le temps : calcaires sur les zones hautes, contemporains de minces couches à matière organique dans les dépressions ; sulfate de calcium sur les aires d'épaisseur moyenne pouvant être encore contemporain de couche à matière organique dans les aires déprimées ; enfin, remplissage par la halite des zones centrales profondes et déprimées. A ces phases successives, se

  12. IMPLEMENTASI HASIL PAP SMEARS PADA PENGEMBANGAN SURVEILANS TERPADU INFEKSI MENULAR SEKSUAL DI JAWA TIMUR (ANALISIS UNTUK MENGEMBANGKAN SURVEILANS-RESPONS IMS

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    Widjiartini Widjiartini

    2012-12-01

    Full Text Available Background: The implementation analysis of Pap Smears result to the integrated Surveillance development of sexual infection in order to respond the IMS and HIV/AIDS cases which increased especially among the housewife and its aim to the implementation Pap Smears result. Results: The Analysis result: 1. Based on the Pap Smears analysis result when its managed properly might be benefited the information not merely detected service cancer which is tend to increase but its also detected fungal infection and 5 types of IMS data: Haemavilus Vaginalis (HV, Gonococoes (Cocen, Trichomonas Vaginalis (TV, Herpes and Virus Papiloma Humanus (HPV which is Cocen and TV tend to increase every years. This data might be used for Surveillance Respond of Pap Smears intended to the productive housewife who is representing susceptible age group against sexual infection and HIV/AIDS. 2. The integrated Surveillance activity of HIV and sexual infection along with eight steps of respond Pap Smears, the structure is matching up with Surveillance of WHO respond and the system and mechanism base on decision of Minister of Health number 1116/2003 to instruct the formation of Surveillance technical implementation and the formation Surveillance technical implementation and the formation Surveillance networking among those units. 3. Developing the integrated Surveillance of sexual infection and HIV/AIDS through the uphold unit Pap Smears is required the determination of basis function, the Surveillance uphold unit, the Respond Surveillance uphold and function, formulation of Protap and Instruction, Training, Monitoring and Evaluation Surveillance System, Communication, Procurement of Coordination and Resources. Exceptional the above mentioned it is necessary pay attention as well as Surveillance structure and quality. Suggestion: 1. Improving the Surveillance Respond System by improving the users of culture information and data for making a decision the unit of Pap Smears

  13. Semper patrui in fratrum filios seviunt. Les oncles se déchaînent toujours contre les fils de leurs frères. Autour de Thietmar de Mersebourg et de sa Chronique. Représentations de la parenté aristocratique en Germanie vers l’an mille dans les sources narratives.

    Directory of Open Access Journals (Sweden)

    Laurence Leleu

    2010-07-01

    Full Text Available Cette étude s’attache à l’analyse du discours élaboré, dans les sources narratives germaniques du Xe et du début du XIe siècle, sur la famille et la parenté aristocratiques, pour envisager les rapports entre autoreprésentation aristocratique, représentation cléricale et réalité sociale. La famille ne se définit pas biologiquement mais est un phénomène historiquement construit. Le discours sur la parenté et la famille, délivré par des clercs, montre comment ceux-ci, et plus globalement le grou...

  14. Evaluation of diagnostic value of AgNOR and PAP in early detection of dysplastic changes in leukoplakia and lichen planus - a preliminary case-control study.

    Science.gov (United States)

    Rao, Dhanya S; Ali, I M; Annigeri, Rajeshwari G

    2017-01-01

    Early detection of oral cancer has been the most effective approach to reduce morbidity and mortality of cancer patients. If a lesion is clinically considered suspicious, an easily practicable, non-invasive, painless, safe, and accurate screening method for detection of the dysplastic changes is necessary. In an attempt to procure this, a study was conducted with the aim of determining the diagnostic accuracy of rapid Papanicolaou stain (PAP) and silver-stained nucleolar organizer regions (AgNOR) in brush biopsies of potentially malignant lesions for early detection of oral cancer. Brush biopsies taken from 25 cases of leukoplakia and lichen planus each were stained with rapid PAP and silver nitrate stains. Histopathological correlation was performed and further compared with rapid PAP and AgNOR for its diagnostic validity. Statistically significant increase in the mean AgNOR count was seen from normal epithelium to lichen planus to that of leukoplakia. When compared with rapid PAP, a linear correlation was seen in AgNOR counts and stages of dysplasia in leukoplakia which was also found to be statistically significant. Diagnostic accuracy for AgNOR in leukoplakia was found to be 84%, lichen planus 73%, whereas RAPID PAP showed 72% accuracy. AgNOR analysis may be useful as a quantitative marker of incipient cellular alterations and hence would be helpful in assessing suspicious lesions and thus can be regarded as a valuable adjunct. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Renewable energy sources in Bulgaria: Current state and trends

    Science.gov (United States)

    Kolev, K.

    The over-dependency of Bulgaria on imported fuel stressed the importance of developing a new energy strategy based on energy saving which includes also using renewable energy sources (RES). The target is the substitution of at least 2 percent of the real primary energy consumption with RES by 2010. The author gives a generalized analysis of the available RES in Bulgaria -solar, wind, geothermal, biomass and mini-hydraulic. The potentialities of each source for its usage as a suitable energy supply are pointed out, as well as the current status of research and implementation work, problems connected with legislation, financing and production of particular facilities. The governmental policy concerning RES is considered briefly. A description is given to the project 'Technical and Economical Assessment of Possibilities for Expansion of the RES-part in the Energy Balance of the Country' developed and started in 1994 in the framework of the PHARE program.

  16. Knowledge of cervical cancer, attitude and husband’s support of Pap smear among multiparous women which have Pap’s smear examination in Aviati clinic Padang Bulan Medan

    Science.gov (United States)

    Feriyawati, L.; Anggraini, D. R.; Fitrie, A. A.; Anggreini, R. N.

    2018-03-01

    Cervical cancer is a serious health problem and stated as the second cause of death of woman worldwide. Several studies have noted a higher incidence of cervical cancer with increasing parity. Early detection with Pap smear is proven to reduce mortality of patients. Knowledge, attitude and husband’s support contributed to theled womanto follow Pap smear examination. This study explores the knowledge of cervical cancer, attitude and husband’ s support of Pap smearin multiparous women that have Pap smear examination. This research is a quantitative study with cross sectional approach recruited 50 respondents as multiparous women that have Pap smear examination inAviati Clinic, Padang Bulan, Medan. The data were collected by self-reports using structured objectives by questionnaires. The result of this study showed that 66% respondents have high knowledge of cervical cancer and 76% respondents have ahigh attitude of Pap smear, but they almost have low husband’s support of Pap smear including information support (62%), emotional support (46%) and real support (50%). This study has revealed that multiparous women that had Pap smear examination generally had high knowledge about cervical cancer and positive attitude about Pap smear, even most of them had low husband’s support.

  17. In Search of the 'New Informal Legitimacy' of Médecins Sans Frontières.

    Science.gov (United States)

    Calain, Philippe

    2012-04-01

    FOR MEDICAL HUMANITARIAN ORGANIZATIONS, MAKING THEIR SOURCES OF LEGITIMACY EXPLICIT IS A USEFUL EXERCISE, IN RESPONSE TO: misperceptions, concerns over the 'humanitarian space', controversies about specific humanitarian actions, challenges about resources allocation and moral suffering among humanitarian workers. This is also a difficult exercise, where normative criteria such as international law or humanitarian principles are often misrepresented as primary sources of legitimacy. This essay first argues for a morally principled definition of humanitarian medicine, based on the selfless intention of individual humanitarian actors. Taking Médecins Sans Frontières (MSF) as a case in point, a common source of moral legitimacy for medical humanitarian organizations is their cosmopolitan appeal to distributive justice and collective responsibility. More informally, their legitimacy is grounded in the rightfulness of specific actions and choices. This implies a constant commitment to publicity and accountability. Legitimacy is also generated by tangible support from the public to individual organizations, by commitments to professional integrity, and by academic alliances to support evidence-based practice and operational research.

  18. Opportunity and prospect analysis of RES utilization for sustainable development of Ekaterinburg city in Russia

    Science.gov (United States)

    Volkov, A.; Aristova, A.

    2017-06-01

    Recently megalopolises have become centres of economy development worldwide. Gradual growth in energy consumption and thereafter - enormous power production and delivery to sustain metropolis’ needs entailed, rapid increase in emissions of hazardous substances in quantities, no longer tolerable for secure residence in majority of these cities. Ekaterinburg, is one of them. In order to abridge harmful pollution in Ekaterinburg and further centralize economic importance of the city, this paper proposes to implement the concept of urban sustainable development/ref. / by introducing alternative energy sources, which would progressively displace traditional fossil fuels. A number of actual cases, where the concept was successfully implemented, were studied and analysed to demonstrate how different shares of renewables can become effective substitutes to conventional energy sources in the cities strongly dependent on them: 1. Energy strategy of Pecs (Hungary); 2. International low carbon city (ILCC) project (Shenzhen, China); 3. Electric power system template of Tangshan city (China). Further, regional environmental and economic specifics of Ekaterinburg were studied to understand power consumption needs and energy generation possibilities, which led authors to conclude on the alternative energy sources feasibility, plot specific flow chart for RES implementation in Ekaterinburg’s power network and outline recommendations for future works.

  19. In media res: commenting on the trajectory of lives.

    Science.gov (United States)

    Bishop, Jeffery; Barina, Rachelle; Stahl, Devan

    2013-01-01

    The stories in this issue of Narrative Inquiry in Bioethics demonstrate two important things. First these stories explore the space between bodily impairment and the social structures that both enable and constrain the flourishing of those who are differently embodied. The authors of these narratives resist the dominant biomedical interpretation of their impairments, but also demonstrate their dependency upon others--social, medical, or familial others. Second, in writing these narratives, the authors are also engaged in an act of identity formation, which sometimes challenge and sometimes embrace the label of disability. By telling their stories in the middle of the action of their lives--in media res, taking up or resisting the label of disability-they also demonstrate the way in which lives can be lived open to new possibilities and interpretations.

  20. Papīra darbi ka domāšanas veicinātāji pirmsskolā

    OpenAIRE

    Jevdokimova, Jūlija

    2017-01-01

    Jūlija J. (2017.) “Papīra darbi kā domāšanas veicinātāji pirmsskolā”. Kvalifikācijas darbs. Rīga: Latvijas Universitātes Pedagoģijas, psiholoģijas un mākslas fakultāte, 90 lpp, 16 att., 4 tab., bibl. 18 nos., latviešu, angļu val. Darbs sastāv no ievada, 5 nodaļām, secinājumiem un 16 pielikumiem. Autors ir vairākus mēnešus izgājis praksi pirmsskolas pedagoga amatā. Darbā ir veikts pētījums par domāšanas attīstību rokdarbu nodarbībās, veicot papīra darbus Darba mērķis ir izzināt un atklāt bēr...

  1. Expression and Significance of the HIP/PAP and RegIIIγ Antimicrobial Peptides during Mammalian Urinary Tract Infection.

    Directory of Open Access Journals (Sweden)

    John David Spencer

    Full Text Available Recent evidence indicates that antimicrobial peptides (AMPs serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC infection. We confirmed induction of RegIIIγ mRNA during cystitis and pyelonephritis by quantitative RT-PCR. Immunoblotting demonstrates increased bladder and urinary RegIIIγ protein levels following UPEC infection. Immunostaining localizes RegIIIγ protein to urothelial cells of infected bladders and kidneys. Human patients with UTI have increased urine concentrations of the orthologous Hepatocarcinoma-Intestine-Pancreas / Pancreatitis Associated Protein (HIP/PAP compared to healthy controls. Recombinant RegIIIγ protein does not demonstrate bactericidal activity toward UPEC in vitro, but does kill Staphylococcus saprophyticus in a dose-dependent manner. Kidney and bladder tissue from RegIIIγ knockout mice and wild-type mice contain comparable bacterial burden following UPEC and Gram-positive UTI. Our results demonstrate that RegIIIγ and HIP/PAP expression is induced during human and murine UTI. However, their specific function in the urinary tract remains uncertain.

  2. A Interlocução de Narrativas: Um Estudo sobre Papéis de Gênero

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    Maria Helena Fávero

    Full Text Available RESUMO Retomamos a distinção entre sexo e gênero e entre papéis sexuais e de gênero na psicologia feminista. Referimos as contraposições à naturalização e discutimos a influência das ideologias da feminilidade e da masculinidade na socialização. Descrevemos um estudo sobre as concepções de quatro mulheres sobre os papéis de gênero, considerando a subjetividade na coleta e análise de dados. Utilizamos a narrativa e o grupo focal, tomando a proposição e os atos da fala como unidades de análise. Evidenciamos seis proposições articuladas a dois eixos principais: (a as condições de vida e o abandono e (b o significado e a prática da maternidade. Discutimos a identificação e o apego na socialização de gênero, defendendo o papel dos estudos psicológicos de gênero para as transformações sociais.

  3. HvPap-1 C1A Protease Participates Differentially in the Barley Response to a Pathogen and an Herbivore

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    Mercedes Diaz-Mendoza

    2017-09-01

    Full Text Available Co-evolutionary processes in plant–pathogen/herbivore systems indicate that protease inhibitors have a particular value in biotic interactions. However, little is known about the defensive role of their targets, the plant proteases. C1A cysteine proteases are the most abundant enzymes responsible for the proteolytic activity during different processes like germination, development and senescence in plants. To identify and characterize C1A cysteine proteases of barley with a potential role in defense, mRNA and protein expression patterns were analyzed in response to biotics stresses. A barley cysteine protease, HvPap-1, previously related to abiotic stresses and grain germination, was particularly induced by flagellin or chitosan elicitation, and biotic stresses such as the phytopathogenic fungus Magnaporthe oryzae or the phytophagous mite Tetranychus urticae. To elucidate the in vivo participation of this enzyme in defense, transformed barley plants overexpressing or silencing HvPap-1 encoding gene were subjected to M. oryzae infection or T. urticae infestation. Whereas overexpressing plants were less susceptible to the fungus than silencing plants, the opposite behavior occurred to the mite. This unexpected result highlights the complexity of the regulatory events leading to the response to a particular biotic stress.

  4. Expression and Significance of the HIP/PAP and RegIIIγ Antimicrobial Peptides during Mammalian Urinary Tract Infection

    Science.gov (United States)

    Spencer, John David; Jackson, Ashley R.; Li, Birong; Ching, Christina B.; Vonau, Martin; Easterling, Robert S.; Schwaderer, Andrew L.; McHugh, Kirk M.; Becknell, Brian

    2015-01-01

    Recent evidence indicates that antimicrobial peptides (AMPs) serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ) as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC) infection. We confirmed induction of RegIIIγ mRNA during cystitis and pyelonephritis by quantitative RT-PCR. Immunoblotting demonstrates increased bladder and urinary RegIIIγ protein levels following UPEC infection. Immunostaining localizes RegIIIγ protein to urothelial cells of infected bladders and kidneys. Human patients with UTI have increased urine concentrations of the orthologous Hepatocarcinoma-Intestine-Pancreas / Pancreatitis Associated Protein (HIP/PAP) compared to healthy controls. Recombinant RegIIIγ protein does not demonstrate bactericidal activity toward UPEC in vitro, but does kill Staphylococcus saprophyticus in a dose-dependent manner. Kidney and bladder tissue from RegIIIγ knockout mice and wild-type mice contain comparable bacterial burden following UPEC and Gram-positive UTI. Our results demonstrate that RegIIIγ and HIP/PAP expression is induced during human and murine UTI. However, their specific function in the urinary tract remains uncertain. PMID:26658437

  5. The Nordic welfare model providing energy transition? A political geography approach to the EU RES directive

    International Nuclear Information System (INIS)

    Westholm, Erik; Beland Lindahl, Karin

    2012-01-01

    The EU Renewable Energy Strategy (RES) Directive requires that each member state obtain 20% of its energy supply from renewable sources by 2020. If fully implemented, this implies major changes in institutions, infrastructure, land use, and natural resource flows. This study applies a political geography perspective to explore the transition to renewable energy use in the heating and cooling segment of the Swedish energy system, 1980–2010. The Nordic welfare model, which developed mainly after the Second World War, required relatively uniform, standardized local and regional authorities functioning as implementation agents for national politics. Since 1980, the welfare orientation has gradually been complemented by competition politics promoting technological change, innovation, and entrepreneurship. This combination of welfare state organization and competition politics provided the dynamics necessary for energy transition, which occurred in a semi-public sphere of actors at various geographical scales. However, our analysis, suggest that this was partly an unintended policy outcome, since it was based on a welfare model with no significant energy aims. Our case study suggests that state organization plays a significant role, and that the EU RES Directive implementation will be uneven across Europe, reflecting various welfare models with different institutional pre-requisites for energy transition. - Highlights: ► We explore the energy transition in the heating/cooling sector in Sweden 1980–2000. ► The role of the state is studied from a political geography perspective. ► The changing welfare model offered the necessary institutional framework. ► Institutional arrangements stand out as central to explain the relative success. ► The use of renewables in EU member states will continue to vary significantly.

  6. Integrated electrification solution for autonomous electrical networks on the basis of RES and energy storage configurations

    International Nuclear Information System (INIS)

    Kaldellis, J.K.

    2008-01-01

    Most medium and small islands of the Aegean Archipelagos face serious infrastructure problems, strongly related with the limited electrical energy available at extremely high cost. On the other hand, the area is characterized by very high wind speeds and abundant solar energy, thus the exploitation of the available renewable energy sources (RES) may significantly contribute to the fulfillment of the local societies energy demand at minimum environmental and macroeconomic cost. However, the stochastic availability of wind energy and the variable availability of solar energy, the daily and seasonal electricity demand fluctuations, as well as the limited local electrical network capacity result in serious restrictions concerning the maximum renewable power penetration. In this context, the present paper investigates the possibility of creating a combined electricity generation facility based on the exploitation of wind or/and solar potential of an area as well as on the utilization of an appropriate energy storage configuration in order to replace the existing thermal power stations with rational investment requirements. For this purpose, the major parameters of the proposed integrated configuration are firstly calculated and its financial viability is accordingly analyzed. One of the main targets of the proposed solution is to maximize the RES exploitation of the area at a minimum electricity generation cost, while special emphasis is given in order to select the most cost-efficient energy storage device available. According to the results obtained the proposed solution is not only financially attractive but also improves the quality of the electricity offered to the local communities, substituting the expensive and heavily polluting existing thermal power stations

  7. Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro

    Directory of Open Access Journals (Sweden)

    Zahraa Salim M. Al-Garawi

    2012-01-01

    Full Text Available In this study, two new Schiff base compounds derived from the condensation reaction of L-glycine and L-tryptophan with 4-methylbenzal-dehyde have been synthesized. The Schiff base compounds were characterized by FT-IR, UV and 1H NMR spectroscopy. Their effects on the activity of total (ACP, prostatic (PAP and non prostatic (NPA acid phosphatase enzymes were studied. The Schiff base derived from L-glycine (A demonstrated inhibition effect on the ACP and NPA activities and activation effect on PAP activity. The Schiff base derived from L-tryptophan (B demonstrated semi fixed inhibition effects on the ACP and NPA activities at high concentrations (5.5×10-2, 5.5×10-3 and 5.5×10-4 M and activator effect at low concentration (5.5×10-5 M while it was exhibits as activator on PAP activity.

  8. Effects of an educational intervention based on the protection motivation theory and implementation intentions on first and second pap test practice in Iran.

    Science.gov (United States)

    Dehdari, Tahereh; Hassani, Laleh; Hajizadeh, Ebrahim; Shojaeizadeh, Davoud; Nedjat, Saharnaz; Abedini, Mehrandokht

    2014-01-01

    Few Iranian women take the Papanicolaou test despite its important role in preventing cervical cancer. This study aimed to determine the effectiveness of an educational intervention based on the protection motivation theory (PMT) variables and implementation intentions in the first and second Pap test practice among Iranian women. In this quasi-randomized controlled trial, 200 women who were referred to 30 primary health care clinics in Tehran were randomly selected. PMT variables and Pap test practice were measured at baseline and again after 3 and 15 months. The 4-week educational intervention program was conducted for the intervention group. Following the intervention, the mean scores of self-efficacy, perceived vulnerability, and behavior intention variables were significantly higher in the intervention group when compared to the control group (ptheory-based framework for developing educational interventions regarding Pap test practice in Iran.

  9. DEVELOPMENT OF A PEROXIDASE-ANTIPEROXIDASE (PAP) TECHNIQUE FOR THE IDENTIFICATION OF HAEMOPHILUS-SOMNUS IN PNEUMONIC CALF LUNGS IN DENMARK

    DEFF Research Database (Denmark)

    Tegtmeier, Conny; Jensen, N.E.; Jensen, H.E.

    1995-01-01

    A peroxidase-antiperoxidase (PAP) technique was developed for the identification of Haemophilus somnus bacteria in lung tissues of calves. Antisera raised against somatic and wall antigens of a Danish and American strain of H. somnus were produced. Experimentally infected murine tissues were used...... strain of H. somnus revealed the highest sensitivity in the PAP technique and became specific following absorption. Heterologous absorption also rendered this antiserum specific in crossed immunoelectrophoresis. Subsequently, the PAP technique was applied on formalin-fixed pneumonic lung tissues of 86...... calves. An immunodiagnosis of H. somnus pneumonia was obtained in 15 of 17 lungs from which the bacterium had been isolated. Moreover, immunostained bacteria were also demonstrated in 20 lungs from which H. somnus had not been isolated. Thus, application of immunohistochemistry significantly enhanced...

  10. Human papilloma virus testing knowledge and attitudes among women attending colposcopy clinic with ASCUS/LGSIL pap smears.

    Science.gov (United States)

    Le, T; Hicks, W; Menard, C; Boyd, D; Hewson, T; Hopkins, L; Kee Fung, M Fung

    2004-09-01

    To study women's knowledge regarding the role of human papilloma virus (HPV) in cervical intraepithelial neoplasia and their attitudes toward the integration of HPV testing as part of routine follow-up of atypical squamous cell of uncertain significance/low-grade squamous intraepithelial lesion (ASCUS/LGSIL) abnormalities. Over a 12-month period, all women attending the University of Ottawa colposcopy clinic for evaluation and follow-up of ASCUS/LGSIL Pap smears were recruited. Demographic data included age, nature of the Pap smear abnormality, gravidity, parity, occupation and education level, smoking history, previous history of abnormal smears, colposcopic examination and treatment, and current method of contraception. The women were asked to rate their level of concern over their Pap smear abnormality, from 0 (not concerned) to 10 (very concerned). Women's knowledge regarding the role of HPV in cervical intraepithelial neoplasia and the rationale behind the use of HPV testing was assessed by the clinic nurse as being minimal, moderate, or good, as defined by pre-specified criteria. Upon explanation by the nurses of the results of the recent ALTS (ASCUS/LGSIL Triage Study) trial, the women were asked to state whether they preferred to continue with regular colposcopic surveillance every 6 months, or to use the results of the HPV test, if negative, to reduce the number of colposcopy examinations to one annually. Descriptive statistics and logistic regression analysis were used to identify significant demographic factors associated with the women's preference for incorporation of HPV testing in their follow-up. All P values less than.10 were considered to be statistically significant, due to the exploratory nature of the study. Of the 100 women who participated in the study, 42% presented with ASCUS. The mean age (+/- SD) of the women was 33.63 +/- 11.25 years (range, 18-75 years); 66% were office workers with at least a community college degree, 86% reported

  11. Physical Activity on Prescription (PAP), in patients with metabolic risk factors. A 6-month follow-up study in primary health care.

    Science.gov (United States)

    Lundqvist, Stefan; Börjesson, Mats; Larsson, Maria E H; Hagberg, Lars; Cider, Åsa

    2017-01-01

    There is strong evidence that inadequate physical activity (PA) leads to an increased risk of lifestyle-related diseases and premature mortality. Physical activity on prescription (PAP) is a method to increase the level of PA of patients in primary care, but needs further evaluation. The aim of this observational study was to explore the association between PAP-treatment and the PA level of patients with metabolic risk factors and the relationship between changes in the PA level and health outcomes at the 6 month follow-up. This study included 444 patients in primary care, aged 27-85 years (56% females), who were physically inactive with at least one component of metabolic syndrome. The PAP-treatment model included: individualized dialogue concerning PA, prescribed PA, and a structured follow-up. A total of 368 patients (83%) completed the 6 months of follow-up. Of these patients, 73% increased their PA level and 42% moved from an inadequate PA level to sufficient, according to public health recommendations. There were significant improvements (p≤ 0.05) in the following metabolic risk factors: body mass index, waist circumference, systolic blood pressure, fasting plasma glucose, cholesterol, and low density lipoprotein. There were also significant improvements regarding health-related quality of life, assessed by the Short Form 36, in: general health, vitality, social function, mental health, role limitation-physical/emotional, mental component summary, and physical component summary. Regression analysis showed a significant association between changes in the PA level and health outcomes. During the first 6-month period, the caregiver provided PAP support 1-2 times. This study indicates that an individual-based model of PAP-treatment has the potential to change people's PA behavior with improved metabolic risk factors and self-reported quality of life at the 6 month follow-up. Thus, PAP seems to be feasible in a clinical primary care practice, with minimum effort

  12. Physical Activity on Prescription (PAP, in patients with metabolic risk factors. A 6-month follow-up study in primary health care.

    Directory of Open Access Journals (Sweden)

    Stefan Lundqvist

    Full Text Available There is strong evidence that inadequate physical activity (PA leads to an increased risk of lifestyle-related diseases and premature mortality. Physical activity on prescription (PAP is a method to increase the level of PA of patients in primary care, but needs further evaluation. The aim of this observational study was to explore the association between PAP-treatment and the PA level of patients with metabolic risk factors and the relationship between changes in the PA level and health outcomes at the 6 month follow-up. This study included 444 patients in primary care, aged 27-85 years (56% females, who were physically inactive with at least one component of metabolic syndrome. The PAP-treatment model included: individualized dialogue concerning PA, prescribed PA, and a structured follow-up. A total of 368 patients (83% completed the 6 months of follow-up. Of these patients, 73% increased their PA level and 42% moved from an inadequate PA level to sufficient, according to public health recommendations. There were significant improvements (p≤ 0.05 in the following metabolic risk factors: body mass index, waist circumference, systolic blood pressure, fasting plasma glucose, cholesterol, and low density lipoprotein. There were also significant improvements regarding health-related quality of life, assessed by the Short Form 36, in: general health, vitality, social function, mental health, role limitation-physical/emotional, mental component summary, and physical component summary. Regression analysis showed a significant association between changes in the PA level and health outcomes. During the first 6-month period, the caregiver provided PAP support 1-2 times. This study indicates that an individual-based model of PAP-treatment has the potential to change people's PA behavior with improved metabolic risk factors and self-reported quality of life at the 6 month follow-up. Thus, PAP seems to be feasible in a clinical primary care practice, with

  13. Comparison of bloody pap smear fixation by Carnoy’s and fixator spray in samples from women with abnormal uterine bleeding

    Directory of Open Access Journals (Sweden)

    Keshavarz Najmeh

    2016-05-01

    Full Text Available Abnormal uterine bleeding is a serious problem among women of late reproductive age. Cervical cancer is one of the reasons of AUB and Pap smear is the best way to diagnose it. Blood has negative effects on Pap smear especially in AUB with great blood. One of the effective solutions for lysing RBC is Carnoy’s. This study aims to compare two methods of fixation in bloody Pap smear by Carnoy’s and normal spray in samples from women with AUB. This study was done on 204 bloody Pap smear from 102 women with AUB that referred to Zeinabieh and Faghihi hospitals of Shiraz University of Medical Sciences from2012-2013. After observing uterine bleeding in each subject, two samples were provided using usual Pap smear method; one of the slides was fixed by normal spray and the other slide fixed by Carnoy’s solution for20 minutes. After staining (Papanicolaou method, two pathologists performed a double-blind trial to analyze them. Data analysis was done using SPSS. 82 samples did not have cell adequacy. Squamous cells in Carnoy’s-fixed slides were more than spray-fixed ones (p=0.024. The decrease in the number of RBC on slides and the increase in the clarity of slides in Carnoy’s-fixed samples were more than sprayfixed slides (p=0.001, while identifying inflammatory cells(p=0.832 and microbial factors (p=1 in both methods showed no significant difference. Carnoy’s solution can be used as an effective fixative in bloody Pap smear from women with abnormal uterine bleeding.

  14. An institution-based cervical PAP smear study, correlation with clinical findings & histopathology in the Konkan region of Maharashtra state, India

    Directory of Open Access Journals (Sweden)

    Bhushan M. Warpe

    2016-08-01

    Full Text Available Background: Cervical carcinoma is a common cause of death in India. It is presented by spectrum of precancerous lesions, called cervical intraepithelial neoplasia (CIN. Cervical cytological screening is designed to detect over 90% of cytological abnormalities. It has been established that cervical cancers can be diagnosed at the pre-invasive stage with adequate, repetitive cytological screening. Keeping in view of the importance of cervical PAP abnormalities & by classifying them by Bethesda terminology; correlation with clinical findings & histopathological findings was done. Methods: All cervical Pap smears reported in Department of Pathology from 1st August 2015 to 31st July 2016, were prospectively studied and classified according to revised Bethesda terminology, 2014. Also cytoradiological and clinico-cytological, cytohistological correlation was studied. Results: Due to increasing awareness among masses inculcated by social workers, most of the patients for PAP smear cytology came for routine screening to rule out cervical lesions followed by clinical finding of per-vaginal discharge. The 350 screened patients were in the third and fourth decades of life. 99/350 cases were subjected to USG study, with maximum number of cases (34 cases showing normal study, followed by cases with ovarian cysts and fatty liver disease. Negative for intra-epithelial lesion (NILM without any denotable organism was the pre-dominant cytological finding of PAP smear study followed by cases of NILM with bacterial vaginosis (30 cases with two malignancies. Intra-epithelial lesions (IELs were noted in 16.86%. ASCUS comprised 12.29%, ASC-H comprised 1.14%, L-SIL comprised 1.71%, HSIL comprised 1.43%, Atrophic cervical smears comprised 5.14%, Squamous cell carcinoma comprised 0.29% cases. ASC/LSIL ratio was 7.8 and inadequacy rate for PAP smear study was 7.43%. Cytologyhistopathology correlation was possible in 62 cases. Conclusion: Classification of cervical PAP

  15. Overview of renewable energy sources development in France

    International Nuclear Information System (INIS)

    Lengyel, J.; Lepy, S.; Roudergues, J.M.

    2009-01-01

    Generation from Renewable Energy Sources is booming. As for any conventional generation technology, RES specific technical features can be accommodated by the electric system with no tremendous difficulty, provided the grid can be aptly adapted and developed. (authors)

  16. 78 FR 54669 - Draft Environmental Impact Statement for the Proposed RES Americas Moapa Solar Energy Center...

    Science.gov (United States)

    2013-09-05

    ... Environmental Impact Statement for the Proposed RES Americas Moapa Solar Energy Center, Clark County, Nevada... environmental impact statement (DEIS) for the proposed RES Americas Moapa Solar Energy Center on the Moapa River... Progress and on the following Web site: www.MoapaSolarEnergyCenterEIS.com . In order to be fully considered...

  17. Res Publica kõrvaldas mässaja / Kristjan Roos

    Index Scriptorium Estoniae

    Roos, Kristjan, 1978-

    2005-01-01

    Tallinna linnavolikogu Res Publica fraktsiooni juhi kohalt, Res Publica Tallinna piirkonna juhatusest ja erakonna eestseisusest end taandanud Toomas Tautsi sõnul esitati talle erakonna eestseisuses mitmeid süüdistusi, mis kokkuvõtvalt olid etteheited tema vastuseisule võimalikule koalitsioonile Keskerakonnaga. Lisa: Abilinnapeadeks saavad Promm, Reivik ja Pevkur

  18. Res Publica Ida-Viru piirkond valis uue juhatuse / Erik Gamzejev

    Index Scriptorium Estoniae

    Gamzejev, Erik, 1967-

    2002-01-01

    Ilmunud ka: Severnoje Poberezhje 4. dets. lk. 1. Res Publica Ida-Viru piirkonna üldkogul valiti uus juhatus, Vladimir Sarantsevi sõnul oli koosolek enamiku Kohtla-Järve osakonna liikmete arvates õigustühine. Res Publica peasekretäri Tõnis Konsi kommentaare

  19. Res Publica seisab vastu homse arvel elamisele / Siim Männik

    Index Scriptorium Estoniae

    Männik, Siim

    2005-01-01

    Ilmunud ka: Vabariik (venek.) 30. august lk. 1. Res Publica koostab praegu kohalikeks valimisteks nimekirju. Erakond ei plaani korraldada mitte ühte üleriigilist valimiskampaaniat, vaid 120 kohalikku kampaaniat, peale selle on kavas üleriigiline n.-ö. foonikampaania. Lisa: Miks valida Res Publica? Vt. samas: Sisevalimised 1.-3. septembrini

  20. Presidendilossis pidutses ka üks Res Publica liige / Kadri Jakobson

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2006-01-01

    SL Õhtulehele presidendilossis toimunud noortepidudest rääkinud neiu on Res Publica liige, kuid tema sõnul pole tema parteiline kuuluvus pidudega seotud. Arvamust avaldavad Res Publica juhatuse liige Andreas Kaju, erakonna esimees Taavi Veskimägi, ERL-i pressiesindaja Agu Uudelepp jt.

  1. Res Publica mängis topeltmängu / Risto Berendson

    Index Scriptorium Estoniae

    Berendson, Risto, 1975-

    2005-01-01

    Res Publica jätkab koostööd Tallinna linnavalitsuses Reformierakonnaga. Tallinna linnapea Tõnis Paltsi sõnul oli paralleelsete läbirääkimiste pidamine Keskerakonna ja Reformierakonnaga Res Publica Tallinna piirkonna juhatuse valitud taktika. Kommenteerib Jaanus Piirsalu

  2. Ühendpartei Res Publica tiib oli häältekogumisel Isamaast pisut edukam

    Index Scriptorium Estoniae

    2007-01-01

    Ühenderakonna Res Publica tiiva kandidaadid said Riigikogu valimistel umbes tuhat häält rohkem kui Isamaaliidu tiiva kandidaadid, samas oli IRL-i valimisnimekirjas Res Publica tiiva kandidaate ka mõne inimese võrra rohkem. Isamaaliidu edukaimad hääletoojad

  3. Res Publica lihtliikmed tõrjuvad Veskimäge / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2006-01-01

    Ilmunud ka: Pärnu Postimees 17. okt. lk. 6. Isamaa ja Res Publica liidu peaministrikandidaadiks sai Mart Laar, kuid pinged erakondade sees kestavad edasi. Res Publica opositsioon toetab isamaaliitlast Mart Laari ja on Taavi Veskimäe vastu. Lisa: Otsitakse peaministrit

  4. Epidemiology of Chronic Wasting Disease: PrP(res) Detection, Shedding, and Environmental Contamination

    National Research Council Canada - National Science Library

    Williams, Elizabeth S; Miller, Michael W; Lewis, Randolf V; Raisbeck, Merl F; Cook, Walter W

    2004-01-01

    .... The specific goals of these studies are to develop sensitive as says for PrP(exp res) as a marker for infectivity, and use these techniques to monitor the dynamics and modes of shedding of PrP(exp res...

  5. Res Publica nõuab veel üht abilinnapea kohta / Urmas Seaver

    Index Scriptorium Estoniae

    Seaver, Urmas, 1973-

    2005-01-01

    Tallinna linnapea Tõnis Palts on seisukohal, et Reformierakond surus koalitsiooni moodustamisel Res Publicale peale ebaõiglase vastutusvaldkondade jaotuse. Res Publica peasekretär Ott Lumi ei välista võimuliidu loomist Keskerakonnaga, kui Reformierakond järeleandmisi ei tee. ERL tegi ettepaneku kokku kutsuda erakondade ümarlaud. Vt. samas intervjuud Ott Lumiga

  6. Cobertura do exame de Papanicolaou no Brasil e seus fatores determinantes: uma revisão sistemática da literatura Coverage of the Pap smear in Brazil and its determining factors: a systematic literature review

    Directory of Open Access Journals (Sweden)

    Luís Felipe Leite Martins

    2005-08-01

    coberturas abaixo de 70,0% nos últimos três anos. Por outro lado, algumas variáveis foram mais freqüentemente observadas nas mulheres não submetidas ao exame de Papanicolaou: ter baixo nível socioeconômico, ter baixa escolaridade, ter baixa renda familiar e pertencer às faixas etárias mais jovens. CONCLUSÃO: os dados aqui apresentados apontam para desigualdades regionais na cobertura do exame de Papanicolaou na população feminina brasileira e para a necessidade de intervenção junto àqueles fatores a ela associados.PURPOSE: to present an overview of the coverage of the Pap smear in Brazil, emphasizing the determinant factors associated with failure of women to submit to the test. METHODS: the literature was reviewed using the LILACS (Latin-American and Caribbean Literature in Sciences of the Health, MEDLINE - 1966 to 2004 (International Literature in Sciences of the Health, PAHO (Collection of the Library of the Pan-American Organization of Health, and WHOLIS (System of Information of the Library of OMS databases. The review was enlarged through the search of bibliographical references of relevant studies, request for published and unpublished studies by specialists, and other sources. Articles that fulfilled the following criteria were selected: to be a cross-sectional study, carried out in Brazil, including information about periodicity of the Pap test (some time in life or in the last three years and/or containing information about factors associated with failure of women to submit to the test. Duplicates and articles without summary were excluded. A total of 13 articles fulfilling these criteria were selected. RESULTS: there are few studies on the coverage of Pap smear in Brazil. Most of them are concentrated in the big cities of the South and Southeast regions of the country. Besides the shortage, little methodological standardization exists in relation to the sampling and profile of the investigated women, which turns difficult the comparison among them

  7. Hi-Res scan mode in clinical MDCT systems: Experimental assessment of spatial resolution performance.

    Science.gov (United States)

    Cruz-Bastida, Juan P; Gomez-Cardona, Daniel; Li, Ke; Sun, Heyi; Hsieh, Jiang; Szczykutowicz, Timothy P; Chen, Guang-Hong

    2016-05-01

    The introduction of a High-Resolution (Hi-Res) scan mode and another associated option that combines Hi-Res mode with the so-called High Definition (HD) reconstruction kernels (referred to as a Hi-Res/HD mode in this paper) in some multi-detector CT (MDCT) systems offers new opportunities to increase spatial resolution for some clinical applications that demand high spatial resolution. The purpose of this work was to quantify the in-plane spatial resolution along both the radial direction and tangential direction for the Hi-Res and Hi-Res/HD scan modes at different off-center positions. A technique was introduced and validated to address the signal saturation problem encountered in the attempt to quantify spatial resolution for the Hi-Res and Hi-Res/HD scan modes. Using the proposed method, the modulation transfer functions (MTFs) of a 64-slice MDCT system (Discovery CT750 HD, GE Healthcare) equipped with both Hi-Res and Hi-Res/HD modes were measured using a metal bead at nine different off-centered positions (0-16 cm with a step size of 2 cm); at each position, both conventional scans and Hi-Res scans were performed. For each type of scan and position, 80 repeated acquisitions were performed to reduce noise induced uncertainties in the MTF measurements. A total of 15 reconstruction kernels, including eight conventional kernels and seven HD kernels, were used to reconstruct CT images of the bead. An ex vivo animal study consisting of a bone fracture model was performed to corroborate the MTF results, as the detection of this high-contrast and high frequency task is predominantly determined by spatial resolution. Images of this animal model generated by different scan modes and reconstruction kernels were qualitatively compared with the MTF results. At the centered position, the use of Hi-Res mode resulted in a slight improvement in the MTF; each HD kernel generated higher spatial resolution than its counterpart conventional kernel. However, the MTF along the

  8. Regulatory design for RES-E support mechanisms: Learning curves, market structure, and burden-sharing

    International Nuclear Information System (INIS)

    Batlle, C.; Pérez-Arriaga, I.J.; Zambrano-Barragán, P.

    2012-01-01

    Drawing from relevant experiences in power systems around the world, this paper offers a review of existing policy support mechanisms for RES-E, with a detailed analysis of their regulatory implications. While recent studies provide an account of current RES-E support systems, in this paper we focus on some of the impacts these mechanisms have on the overall energy market structure and its performance. Given the rising importance of RES-E in systems everywhere, these impacts should no longer be overlooked. - Highlights: ► This paper offers a critical review of RES-E support mechanisms and their regulatory implications. ► The discussion focuses on how the different schemes impact the performance of the energy markets. ► We propose to redesign of current RES-E mechanisms to optimize incentives and market performance. ► Our recommendation is also to gradually move from price-based mechanisms to auctions.

  9. Using poisson regression to compare rates of unsatisfactory pap smears among gynecologists and to evaluate a performance improvement plan.

    Science.gov (United States)

    Wachtel, Mitchell S; Hatley, Warren G; de Riese, Cornelia

    2009-01-01

    To evaluate impact of a performance improvement (PI) plan implemented after initial analysis, comparing 7 gynecologists working in 2 clinics. From January to October 2005, unsatisfactory rates for gynecologists and clinics were calculated. A PI plan was instituted at the end of the first quarter of 2006. Unsatisfactory rates for each quarter of 2006 and the first quarter of 2007 were calculated. Poisson regression analyzed results. A total of 100 ThinPrep Pap smears initially deemed unsatisfactory underwent reprocessing and revaluation. The study's first part evaluated 2890 smears. Clinic unsatisfactory rates, 2.7% and 2.6%, were similar (p > 0.05). Gynecologists' unsatisfactory rates were 4.8-0.6%; differences between each of the highest 2 and lowest rates were significant (p improvement. Reprocessing ThinPrep smears is an important means of reducing unsatisfactory rates but should not be a substitute for attention to quality in sampling.

  10. Comparing the effect of the order of cell Collection for Pap Smear on the results of cytologic Diagnosis

    Directory of Open Access Journals (Sweden)

    parvin Rahnama

    2005-08-01

    We observed higher proportion of atypical squamous cells of undetermined significance (ASCUS detection in the spatula- first group (33 cases, 59% compared with brush- first group (20 cases, 3.6% which is insignificant (P=0.09. This study showed that the ability of squamous intraepithelial lesion (SIL detection in spatula- first group (27 cases, 4.8%, was comparable to brush-first group (23 cases, 4.1%. Conclusions: Because reported SIL cases are higher when samples are first taken from exocervix and rate of blood contamination increases when samples are taken from endocervix (p=0.004, it is better to take samples first from exocervix for Pap Smear. This strategy increases the chance of diagnosis of cellular lesions of cervix.

  11. RES hyperphagocytosis by rats with streptozotocin-induced diabetes mellitus.

    Science.gov (United States)

    Cornell, R P

    1981-03-01

    In contrast to previous studies of neutrophils from diabetic animals and humans in vitro and of macrophages from diabetic humans in vivo, which reported phagocytic depression, reticuloendothelial system (RES) hyperphagocytosis of colloidal carbon was observed in rats at 14 and 28 days after diabetes induction with streptozotocin (STZ). Carbon clearance half times were significantly enhanced to 6.3 +/- 0.79 and 8.1 +/- 1.04 min at 14 and 28 days post-STZ, respectively, compared with the nondiabetic value (12.7 +/- 0.98 min). The severity of uncontrolled STZ-induced diabetes in rats was confirmed by significant hypoinsulinemia, hyperglucagonemia, hyperglycemia, and hyperlipidemia. Although body weights of STZ-diabetic animals declined progressively, liver weights as a percent of body weight increased above the control value at 14 and 28 days post-STZ. In fact, expression of carbon phagocytosis as the corrected phagocytic index, which accounts for changes in liver and spleen weights relative to body weight, eliminated the significant difference between STZ-diabetic and nondiabetic animals. Antibiotic treatment of diabetic rats failed to alter the hyperphagocytosis, implying that a chronic bacterial infection was not the cause of phagocytic stimulation. Daily insulin replacements, but not a single large insulin dose to 14-day post-STZ rats, reversed the enhanced phagocytosis of colloidal carbon.

  12. Les frontières de la violence au Kenya

    Directory of Open Access Journals (Sweden)

    Claire Médard

    2008-03-01

    Full Text Available Au cours des violences post électorales récentes, au Kenya, de nombreux observateurs ont été surpris par la forme prise par les protestations partisanes. Elle nous rappelle que la fabrique territoriale de l’ethnicité est toujours d’actualité dans ce pays. La réactivation de frontières internes qui portent la marque des violences du passé, certaines héritées de la colonisation et d’autres renégociées depuis l’indépendance, ont mis en péril l’Etat.During the recent post electoral crisis in Kenya, the turn of the protest took many by surprise. We were reminded that the making of ethnicity is on ongoing process in which violence plays a part. New boundaries have appeared, re-enacting old divisions and creating new rifts. Once the mark of administration, internal boundaries now threaten the existence of the State.

  13. Renewable energy sources and ecology

    International Nuclear Information System (INIS)

    Panajotova, Yu.

    1998-01-01

    The share of renewable energy sources (RES) in the world energy balance is estimated from 1-2 to 10% of the total primary energy sources consumption. In EU since 1990 until now the power energy production from these sources is growing continuously by over 3% annually. The features of the updated Environmental Strategy for Bulgaria (ESB) elaborated with the World Bank in 1994 are: increasing the energy efficiency; utilising RES; granting preference to the regional energy concept and establishing regional energy centres based on the EU experience. In ESB the basic priorities are linked with disease factors - pollutants as lead in the air and soils (from leaded petrol, resp. from metallurgical enterprises), dust particles in the air (from household heating, industry and thermo-electric power stations) and sulfur dioxide and other gases (also from energy sector and industry). There is consistent policy for harmonization of the Bulgarian standards with those of the WHO. Among the implemented projects preference is granting to ones concerning new energy saving technologies and RES. Bulgaria got an environmental protection law harmonized with the international legislation and adapted to the economic situation inflicted by the market economy transition. The development of RES needs high investment cost and has low efficiency factor compared to the classical methods of energy production. Implementation of Environmental Action Programme (EAP) in Bulgaria with an international co-operation includes: solid wastes management; water sources management; water pollution problems; soil degradation; transport and environment; nuclear safety and nuclear waste problems and full value utilization of the RES. The Ministry of Environment and local Authorities have to develop their policies and implementing them by a range of activities to identify pollution control strategies, to identify areas where the greatest environmental benefits can be achieved at least cost and to incorporate the

  14. Current experience with support schemes for RES-E in Europe. A regulatory point of view

    International Nuclear Information System (INIS)

    Lackner, Ursula

    2006-01-01

    The need to reduce the dependence of the European economy on imported primary energy and the impact of fossil fuels on the environment has encouraged countries to increase the share of renewable energy sources (RES) for electricity supply. EU Directive 2001/77/EC requires EU Member States to take appropriate steps to introduce new incentive mechanisms in order to reach the target of generating 21 % of the electricity in the EU from RES. At the same time EU Directive 2003/54/EC takes significant steps towards establishing a single market in electricity across the EU. Under this directive, European energy regulators have a number of responsibilities. These include the avoidance of discrimination and the promotion of effective competition along with an efficient functioning of the market. One of their main tasks is to ensure that European consumers pay a final electricity price that is as cost reflective as possible. The final price shall also reflect the social and the environmental costs. At the current stage it is not unlikely that the promotion of renewable energy sources will create significant barriers and distortions on the liberalized electricity market. Several issues arising from the implementation of renewable incentive schemes and policies can be identified and are analysed below; - Conflicting targets on EU-Level; - The variation in the level of incentives may be greater among Member States than is justified by the real level of technology costs, or other factors; - Unbalanced burden sharing for final consumers, due to different allocation mechanisms and designs of support schemes; -The regulation and charges for relevant items of the electricity chain, such as connection and balancing costs, vary significantly among Member States and may introduce competitive advantages. The contents of the paper is as follows: 1 Background; 2 Conflicting targets on EU-Level; 3 Different support levels; 4 Unbalanced burden sharing of final customers; 5 Allocation of

  15. Overexpression of the PAP1 transcription factor reveals a complex regulation of flavonoid and phenylpropanoid metabolism in Nicotiana tabacum plants attacked by Spodoptera litura.

    Science.gov (United States)

    Mitsunami, Tomoko; Nishihara, Masahiro; Galis, Ivan; Alamgir, Kabir Md; Hojo, Yuko; Fujita, Kohei; Sasaki, Nobuhiro; Nemoto, Keichiro; Sawasaki, Tatsuya; Arimura, Gen-ichiro

    2014-01-01

    Anthocyanin pigments and associated flavonoids have demonstrated antioxidant properties and benefits for human health. Consequently, current plant bioengineers have focused on how to modify flavonoid metabolism in plants. Most of that research, however, does not consider the role of natural biotic stresses (e.g., herbivore attack). To understand the influence of herbivore attack on the metabolic engineering of flavonoids, we examined tobacco plants overexpressing the Arabidopsis PAP1 gene (encoding an MYB transcription factor), which accumulated anthocyanin pigments and other flavonoids/phenylpropanoids. In comparison to wild-type and control plants, transgenic plants exhibited greater resistance to Spodoptera litura. Moreover, herbivory suppressed the PAP1-induced increase of transcripts of flavonoid/phenylpropanoid biosynthetic genes (e.g., F3H) and the subsequent accumulation of these genes' metabolites, despite the unaltered PAP1 mRNA levels after herbivory. The instances of down-regulation were independent of the signaling pathways mediated by defense-related jasmonates but were relevant to the levels of PAP1-induced and herbivory-suppressed transcription factors, An1a and An1b. Although initially F3H transcripts were suppressed by herbivory, after the S. litura feeding was interrupted, F3H transcripts increased. We hypothesize that in transgenic plants responding to herbivory, there is a complex mechanism regulating enriched flavonoid/phenylpropanoid compounds, via biotic stress signals.

  16. Overexpression of the PAP1 transcription factor reveals a complex regulation of flavonoid and phenylpropanoid metabolism in Nicotiana tabacum plants attacked by Spodoptera litura.

    Directory of Open Access Journals (Sweden)

    Tomoko Mitsunami

    Full Text Available Anthocyanin pigments and associated flavonoids have demonstrated antioxidant properties and benefits for human health. Consequently, current plant bioengineers have focused on how to modify flavonoid metabolism in plants. Most of that research, however, does not consider the role of natural biotic stresses (e.g., herbivore attack. To understand the influence of herbivore attack on the metabolic engineering of flavonoids, we examined tobacco plants overexpressing the Arabidopsis PAP1 gene (encoding an MYB transcription factor, which accumulated anthocyanin pigments and other flavonoids/phenylpropanoids. In comparison to wild-type and control plants, transgenic plants exhibited greater resistance to Spodoptera litura. Moreover, herbivory suppressed the PAP1-induced increase of transcripts of flavonoid/phenylpropanoid biosynthetic genes (e.g., F3H and the subsequent accumulation of these genes' metabolites, despite the unaltered PAP1 mRNA levels after herbivory. The instances of down-regulation were independent of the signaling pathways mediated by defense-related jasmonates but were relevant to the levels of PAP1-induced and herbivory-suppressed transcription factors, An1a and An1b. Although initially F3H transcripts were suppressed by herbivory, after the S. litura feeding was interrupted, F3H transcripts increased. We hypothesize that in transgenic plants responding to herbivory, there is a complex mechanism regulating enriched flavonoid/phenylpropanoid compounds, via biotic stress signals.

  17. Overexpression of the PAP1 Transcription Factor Reveals a Complex Regulation of Flavonoid and Phenylpropanoid Metabolism in Nicotiana tabacum Plants Attacked by Spodoptera litura

    Science.gov (United States)

    Mitsunami, Tomoko; Nishihara, Masahiro; Galis, Ivan; Alamgir, Kabir Md; Hojo, Yuko; Fujita, Kohei; Sasaki, Nobuhiro; Nemoto, Keichiro; Sawasaki, Tatsuya; Arimura, Gen-ichiro

    2014-01-01

    Anthocyanin pigments and associated flavonoids have demonstrated antioxidant properties and benefits for human health. Consequently, current plant bioengineers have focused on how to modify flavonoid metabolism in plants. Most of that research, however, does not consider the role of natural biotic stresses (e.g., herbivore attack). To understand the influence of herbivore attack on the metabolic engineering of flavonoids, we examined tobacco plants overexpressing the Arabidopsis PAP1 gene (encoding an MYB transcription factor), which accumulated anthocyanin pigments and other flavonoids/phenylpropanoids. In comparison to wild-type and control plants, transgenic plants exhibited greater resistance to Spodoptera litura. Moreover, herbivory suppressed the PAP1-induced increase of transcripts of flavonoid/phenylpropanoid biosynthetic genes (e.g., F3H) and the subsequent accumulation of these genes' metabolites, despite the unaltered PAP1 mRNA levels after herbivory. The instances of down-regulation were independent of the signaling pathways mediated by defense-related jasmonates but were relevant to the levels of PAP1-induced and herbivory-suppressed transcription factors, An1a and An1b. Although initially F3H transcripts were suppressed by herbivory, after the S. litura feeding was interrupted, F3H transcripts increased. We hypothesize that in transgenic plants responding to herbivory, there is a complex mechanism regulating enriched flavonoid/phenylpropanoid compounds, via biotic stress signals. PMID:25268129

  18. RNA-seq analysis of antibiotic-producing Bacillus subtilis SC-8 in response to signal peptide PapR of Bacillus cereus.

    Science.gov (United States)

    Yeo, In-Cheol; Lee, Nam Keun; Yang, Byung Wook; Hahm, Young Tae

    2014-01-01

    Bacillus subtilis SC-8 produces an antibiotic that has narrow antagonistic activity against bacteria in the Bacillus cereus group. In B. cereus group bacteria, peptide-activating PlcR (PapR) plays a significant role in regulating the transcription of virulence factors. When B. subtilis SC-8 and B. cereus are co-cultured, PapR is assumed to stimulate antibiotic production by B. subtilis SC-8. To better understand the effect of PapR on this interspecies interaction, the global transcriptome profile of B. subtilis SC-8 was analyzed in the presence of PapR. Significant changes were detected in 12.8 % of the total transcripts. Genes related to amino acid transport and metabolism (16.5 %) and transcription (15 %) were mainly upregulated, whereas genes involved in carbohydrate transport and metabolism (12.7 %) were markedly downregulated. The expression of genes related to transcription, including several transcriptional regulators and proteins involved in tRNA biosynthesis, was increased. The expression levels of genes associated with several transport systems, such as antibiotic, cobalt, and iron complex transporters, was also significantly altered. Among the downregulated genes were transcripts associated with spore formation, the subtilosin A gene cluster, and nitrogen metabolism.

  19. The frequency of herpes simplex virus changes in anal Pap smear and its association with squamous intraepithelial lesions in high-risk male patients.

    Science.gov (United States)

    Greebon, Leslie J; Avery, Diane L; Prihoda, Thomas J; Valente, Philip T; Policarpio-Nicolas, Maria Luisa C

    2014-06-01

    While there are studies postulating a model of synergism between human papillomavirus (HPV) and herpes simplex virus (HSV) in cervical carcinogenesis, the frequency of anal herpes as well as its association with anal squamous intraepithelial lesions (ASILs) has been understudied in men. This study evaluates the frequency of HSV changes in anal Pap smears and its association with ASILs in a high-risk population. A computerized search for specimens associated with anal cytology that had positive findings of HSV was performed. The electronic medical records were examined for past diagnosis of herpes, HSV serology prior to or after cytology, and if the patient received treatment after cytologic diagnosis of HSV. Of the 470 anal Pap smears (Thin-prep) examined, seven had cellular changes consistent with HSV infection. All patients were asymptomatic human immunodeficiency virus (HIV) positive males with no prior HSV serology tests. Two patients had prior diagnoses of HSV infection. Cytologic abnormalities were identified in 86% ranging from atypical squamous cells of undetermined significance to high grade squamous intraepithelial lesion. Three patients were treated after the HSV cytologic diagnosis. The frequency of HSV changes in anal Pap smear is low (1.48%), but the presence of concomitant cytologic abnormalities is high (86%). While our findings suggest the possible role of HSV as a HPV co-factor in ASILs, larger studies are needed to support this. Identification of HSV infection on anal Pap smear is important for institution of patient treatment and subsequent reduction of transmission. Copyright © 2014 Wiley Periodicals, Inc.

  20. Development of an instrument based on the protection motivation theory to measure factors influencing women's intention to first pap test practice.

    Science.gov (United States)

    Hassani, Lale; Dehdari, Tahereh; Hajizadeh, Ebrahim; Shojaeizadeh, Davoud; Abedini, Mehrandokht; Nedjat, Saharnaz

    2014-01-01

    Given that there are many Iranian women who have never had a Pap smear, this study was designed to develop and validate a measurement tool based on the Protection Motivation Theory to assess factors influencing the Iranian women's intention to perform first Pap testing. In this psychometric research, to determine the Content Validity Index (CVI) and the Content Validity Ratio (CVR), a panel of experts (n=10) reviewed scale items. Reliability was estimated through the Intraclass Correlation Coefficient (n=30) and internal consistency (n=240). Also, factor analysis (exploratory and conformity) was performed on the data of the sample women who had never had a Pap smear test (n=240). A 26-item questionnaire was developed. The CVI and CVR scores of the scale were 0.89 and 0.90, respectively. Exploratory factor analysis loaded a 26-item with seven factors questionnaire (perceived vulnerability and severity, fear, response costs, response efficacy, self-efficacy, and protection motivation (or intention)) that jointly accounted for 72.76% of the observed variance. Confirmatory factor analysis indicated a good fit for the data. Internal consistency (range 0.70-0.93) and test-retest reliability (range 0.72-0.96) of sub-scales were acceptable. This study showed that the designed instrument was a valid and reliable tool for measuring the factors influencing the women's intention to perform their first Pap testing.

  1. Inequity of healthcare utilization on mammography examination and Pap smear screening in Thailand: Analysis of a population-based household survey.

    Directory of Open Access Journals (Sweden)

    Sukanya Chongthawonsatid

    Full Text Available Healthcare in Thailand is not equally distributed, and not all people can equally access healthcare resources even if they are covered by health insurance. To examine factors associated with the utilization of mammography examination for breast cancer and Pap smear screening for cervical cancer, data from the national reproductive health survey conducted by the National Statistical Office of Thailand in 2009 was examined. The survey was carried out on 15,074,126 women aged 30-59 years. The results showed that the wealthier respondents had more mammograms than did the lower-income groups. The concentration index was 0.144. The data on Pap smears for cervical cancer also showed that the wealthier respondents were more likely to have had a Pap smear than their lower-income counterparts. The concentration index was 0.054. Determinants of mammography examination were education, followed by health welfare and wealth index, whereas the determinants of Pap smear screening were wealth index, followed by health welfare and education. The government should support greater education for women because education was associated with socioeconomic status and wealth. There should be an increase in the number of screening campaigns, mobile clinics, and low-cost mammograms and continued support for accessibility to mammograms, especially in rural areas and low-income communities.

  2. A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology.

    Science.gov (United States)

    Zappacosta, Roberta; Lattanzio, Giuseppe; Viola, Patrizia; Ianieri, Manuel Maria; Gatta, Daniela Maria Pia; Rosini, Sandra

    2014-01-01

    The introduction of organized cervical cancer (CC) screening programs has drastically reduced the prevalence of CC. However the incidence is still too high, especially among elderly women. All guidelines strongly recommend a regular Papanicolaou (Pap) testing for young and middle-aged patients. On the other hand, many international professional societies no longer advise screening in women who have undergone hysterectomy, and in women aged 65 years and above, who have a previous history of regular Pap smears. Here we report the case of poorly differentiated CC, involving the pelvic lymph nodes and urinary bladder, occurring in a 79-year-old woman who regularly underwent Pap tests, with no reported cytological abnormalities. In this very rare case, the CC cells, as well as cells from metastatic lymph nodes and cells from urinary specimens, molecularly showed human papilloma virus (HPV)-53. With the limitations of a single case, this report brings important information to prevent CC in elderly patients: the utility of molecular tests to increase sensitivity of Pap smears in postmenopausal women; the importance of HPV-53 as one of the four "emergent" genotypes having a possible role in oncogenesis; and the presence of HPV-53 in lymph node metastases from cervical carcinoma, which would support the role of this virus in the maintenance of malignant status.

  3. High throughput virtual screening and in silico ADMET analysis for rapid and efficient identification of potential PAP248-286 aggregation inhibitors as anti-HIV agents

    Science.gov (United States)

    Malik, Ruchi; Bunkar, Devendra; Choudhary, Bhanwar Singh; Srivastava, Shubham; Mehta, Pakhuri; Sharma, Manish

    2016-10-01

    Human semen is principal vehicle for transmission of HIV-1 and other enveloped viruses. Several endogenous peptides present in semen, including a 39-amino acid fragments of prostatic acid phosphatase (PAP248-286) assemble into amyloid fibrils named as semen-derived enhancer of viral infection (SEVI) that promote virion attachment to target cells which dramatically enhance HIV virus infection by up to 105-fold. Epigallocatechin-3-gallate (EGCG), a polyphenolic compound, is the major catechin found in green tea which disaggregates existing SEVI fibers, and inhibits the formation of SEVI fibers. The aim of this study was to screen a number of relevant polyphenols to develop a rational approach for designing PAP248-286 aggregation inhibitors as potential anti-HIV agents. The molecular docking based virtual screening results showed that polyphenolic compounds 2-6 possessed good docking score and interacted well with the active site residues of PAP248-286. Amino acid residues of binding site namely; Lys255, Ser256, Leu258 and Asn265 are involved in binding of these compounds. In silico ADMET prediction studies on these hits were also found to be promising. Polyphenolic compounds 2-6 identified as hits may act as novel leads for inhibiting aggregation of PAP248-286 into SEVI.

  4. Attitudes and factors affecting acceptability of self-administered cervicovaginal sampling for human papillomavirus (HPV) genotyping as an alternative to Pap testing among multiethnic Malaysian women

    Science.gov (United States)

    Ma'som, Mahirah; Bhoo-Pathy, Nirmala; Nasir, Nazrila Hairizan; Bellinson, Jerome; Subramaniam, Shridevi; Ma, Yuntong; Yap, Siew-Hwei; Goh, Pik-Pin; Gravitt, Patti; Woo, Yin Ling

    2016-01-01

    Objective The objective of this study was to determine the attitudes and acceptability of self-administered cervicovaginal sampling compared with conventional physician-acquired Papanicolaou (Pap) smear among multiethnic Malaysian women. Method A cross-sectional study was carried out via interviewer-administered surveys from August 2013 through August 2015 at five government-run, urban health clinics in the state of Selangor. Subjects were participants from an ongoing community-based human papillomavirus (HPV) prevalence study who answered a standard questionnaire before and after self-sampling. The cervicovaginal self-sampling for HPV genotyping was performed using a simple brush (‘Just for Me’; Preventive Oncology International, Hong Kong). Detailed data on sociodemographics, previous Pap smear experience, and attitudes towards self-administered cervicovaginal sampling were collected and analysed. Acceptability was inferred using a five-item Likert scale that included six different subjective descriptives: experience, difficulty, convenience, embarrassment, discomfort or pain, and confidence in collecting one's own sample. Results Of the 839 participants, 47.9% were Malays, followed by 30.8% Indians, 18.8% Chinese and 2.5% from other ethnicities. The median age of the participants was 38 years (IQR 30–48). Some 68.2% of participants indicated a preference for self-sampling over the Pap test, with 95% indicating willingness to follow-up a positive result at the hospital. Age, ethnicity and previous Pap test experience were significant independent factors associated with preference for self-sampling. The older the individual, the less likely they were to prefer self-sampling (adjusted OR 0.94, 95% CI 0.90 to 0.98). The Chinese were less likely to prefer self-sampling (72.6%) than the Malays (85.1%) (adjusted OR 0.57, 95% CI 0.33 to 0.98, p=0.004). Participants who had never undergone a Pap smear were also more likely to prefer self-sampling (88.5%) than

  5. Challenges and prospects of electricity production from renewable energy sources in Slovenia

    International Nuclear Information System (INIS)

    Al-Mansour, Fouad; Sucic, Boris; Pusnik, Matevz

    2014-01-01

    Development of the utilisation of renewable energy sources and energy efficiency represents the main policy for sustainable development. The overall target of the European Union Directive on the promotion of the use of energy from renewables (RES) is to achieve at least a 20% share of energy from renewables in the gross final energy consumption in 2020. The mandatory national target for Slovenia is a 25% share of energy from RES in the gross final consumption. The share of RES in the gross final energy consumption in Slovenia was 18.8% in 2011 and the share of electricity production from RES was 30.8% in the gross electricity consumption. Electricity production from photovoltaics (PV) and biogas plants in agriculture has been growing fast after the adoption of the new supportive decree for electricity from RES in 2009. The very fast growth of PV plants has caused a problem for financing electricity from RES. Similar effects have been also recorded in the biogas sector, which represents a threat to food production. The state of the art, targets and challenges of electricity production from RES in Slovenia are described in the paper. - Highlights: • Slovenia's RES policy, regulatory frameworks and incentives are described. • The most important development challenges of the RES-E sector are discussed. • RES-E policy priorities need to be reassessed in view of recent global trends. • Responsible policy making and implementation follow-up are necessary

  6. Cervical Cancer Screening Preferences Among Trans-Masculine Individuals: Patient-Collected Human Papillomavirus Vaginal Swabs Versus Provider-Administered Pap Tests.

    Science.gov (United States)

    McDowell, Michal; Pardee, Dana J; Peitzmeier, Sarah; Reisner, Sari L; Agénor, Madina; Alizaga, Natalie; Bernstein, Ida; Potter, Jennifer

    2017-08-01

    Trans-masculine (TM, i.e., persons who have a masculine spectrum gender identity, but were assigned female sex at birth) individuals face disparities in cervical cancer screening rates compared to cisgender women. Some unique barriers to screening in this population are specific to Pap tests. Introduction of self-collected frontal (i.e., vaginal) swabs for human papillomavirus (HPV) testing as a screening strategy may obviate these barriers. This study elucidates cervical cancer screening preferences among TM individuals. TM individuals participated in in-depth interviews (n = 31) and online surveys (n = 32) to explore perceptions and experiences regarding cervical cancer screening, including the acceptability of self-collected frontal HPV swabs for cervical cancer screening compared to provider-administered Pap tests. Provider-collected frontal HPV swab acceptability was also explored. Most TM individuals (94% in-person and 91% online participants) preferred either the self- or provider-collected frontal HPV swab to the Pap test. Participants perceived self- and provider-collected frontal HPV swabs to be less invasive, provoke less gender discordance, and promote a greater sense of agency compared to Pap tests. However, some participants expressed concern about HPV swab accuracy and, regarding the self-collected swab, discomfort about the need to engage with genitals they may not want to acknowledge. Individuals who reported positive provider relationships found Pap tests and provider-collected frontal swabs more acceptable than those who did not. Frontal HPV swabs have the potential to promote regular cervical cancer screening among TM individuals and to narrow screening disparities. Work is ongoing to establish swab accuracy and develop shared decision-making tools.

  7. Investigation of the Role of Training Health Volunteers in Promoting Pap Smear Test Use among Iranian Women Based on the Protection Motivation Theory.

    Science.gov (United States)

    Ghahremani, Leila; Harami, Zahra Khiyali; Kaveh, Mohammad Hossein; Keshavarzi, Sareh

    2016-01-01

    Cervical cancer is known as one of the most prevalent types of cancers and a major public health problem in developing countries which can be detected by Pap test, prevented, and treated. Despite the effective role of Pap test in decreasing the incidence and mortality due to cervical cancer, it is still one the most common causes of cancer-related deaths among women, especially in developing countries. Thus, this study aimed to examine the effect of educational interventions implemented by health volunteers based on protection motivation theory (PMT) on promoting Pap test use among women. This quasi-experimental study was conducted on 60 health volunteers and 420 women. The study participants were divided into an intervention and a control group. Data were collected using a valid self-reported questionnaire including demographic variables and PMT constructs which was completed by both groups before and 2 months after the intervention. Then, the data were entered into the SPSS statistical software, version 19 and were analyzed using Chi-square test, independent T-test, and descriptive statistical methods. P<0.05 was considered as statistically significant. The findings of this study showed that the mean scores of PMT constructs (i.e. perceived vulnerability, perceived severity, fear, response-costs, self-efficacy, and intention) increased in the intervention group after the intervention (P<0.001). However, no significant difference was found between the two groups regarding response efficacy after the intervention (P=0.06). The rate of Pap test use also increased by about 62.9% among the study women. This study showed a significant positive relationship between PMT-based training and Pap test use. The results also revealed the successful contribution of health volunteers to training cervical cancer screening. Thus, training interventions based on PMT are suggested to be designed and implemented and health volunteers are recommended to be employed for educational

  8. The effect of health education on the knowledge, attitude, and uptake of free Pap smear among female teachers in Birnin-Kebbi, North-Western Nigeria.

    Science.gov (United States)

    Adamu, A N; Abiola, A O; Ibrahim, Mto

    2012-01-01

    The Routine Pap smear test has successfully reduced the incidence of invasive cervical cancer in the presence of a proper structure for its implementation. This study was designed to assess the effect of health education on the knowledge, attitude, and uptake of Pap smear among female teachers. It was a quasi-experimental, controlled study with a pre-test, post-test design. A total of 100 respondents were recruited for each of the intervention and control groups, by the multistage sampling technique. The mean knowledge score of cervical cancer was low in both the interventions (25.5% ± 10.5) and control groups (18.9% ± 10.0) at baseline; a significant rise to 57.2% ± 20.7 was recorded after the intervention in the Intervention group (Pfree Pap smear was poor at the post-intervention phase in both the groups (P=0.45). Reported reasons for poor uptake included the respondents' dislike for the test (38.4%) and the belief that the test was not necessary (24.4%). About 20% of the respondents did not have any reason at all. Health education had no significant effect on the uptake of a free Pap smear among teachers. Despite the significant improvement in the attitude toward the test, many respondents did not like the test after than before the intervention. Sociocultural issues such as the gender of the sample collector, and system factors like few service delivery points, and the time required to access the service could have contributed to the poor uptake recorded in this study. A program designed to improve routine cervical cancer screening by Pap smear should therefore address not only the knowledge and cost, but also the sociocultural and systemic factors.

  9. Factors related to the practice of breast self examination (BSE and Pap smear screening among Malaysian women workers in selected electronics factories

    Directory of Open Access Journals (Sweden)

    Shamsuddin K

    2003-05-01

    Full Text Available Abstract Background The Malaysian Ministry of Health promotes breast self-examination (BSE for all women, and Pap smear screening every three years for all sexually active women ages 20 years and above. The objectives of this paper were to examine the practice of these two screening tests among women production workers in electronics factories, and to identify factors related to practice. Methods This was a cross-sectional survey of women production workers from ten electronics factories. Data was collected by a self-administered questionnaire from a total of 1,720 women. The chi-square test, odds ratio and binomial logistic regression were used in bivariate and multivariate analysis. Results Prevalence rates were 24.4% for BSE once a month, and 18.4% for Pap smear examination within the last three years. Women who were significantly more likely to perform BSE every month were 30 years and older, Malays, with upper secondary education and above, answered the BSE question correctly, and had a Pap smear within the last three years. The proportion of women who had a Pap smear within the last three years were significantly higher among those who were older, married, with young children, on the contraceptive pill or intra-uterine device, had a medical examination within the last five years, answered the Pap smear question correctly, and performed BSE monthly. Conclusion Screening practice rates in this study were low when compared to national rates. Socio-demographic and health care factors significantly associated with screening practice are indicative of barriers which should be further understood so that more effective educational and promotional strategies could be developed.

  10. Cardiovascular Small Heat Shock Protein HSPB7 Is a Kinetically Privileged Reactive Electrophilic Species (RES) Sensor.

    Science.gov (United States)

    Surya, Sanjna L; Long, Marcus J C; Urul, Daniel A; Zhao, Yi; Mercer, Emily J; EIsaid, Islam M; Evans, Todd; Aye, Yimon

    2018-02-08

    Small heat shock protein (sHSP)-B7 (HSPB7) is a muscle-specific member of the non-ATP-dependent sHSPs. The precise role of HSPB7 is enigmatic. Here, we disclose that zebrafish Hspb7 is a kinetically privileged sensor that is able to react rapidly with native reactive electrophilic species (RES), when only substoichiometric amounts of RES are available in proximity to Hspb7 expressed in living cells. Among the two Hspb7-cysteines, this RES sensing is fulfilled by a single cysteine (C117). Purification and characterizations in vitro reveal that the rate for RES adduction is among the most efficient reported for protein-cysteines with native carbonyl-based RES. Covalent-ligand binding is accompanied by structural changes (increase in β-sheet-content), based on circular dichroism analysis. Among the two cysteines, only C117 is conserved across vertebrates; we show that the human ortholog is also capable of RES sensing in cells. Furthermore, a cancer-relevant missense mutation reduces this RES-sensing property. This evolutionarily conserved cysteine-biosensor may play a redox-regulatory role in cardioprotection.

  11. Hydrogen-induced structural transition in single layer ReS2

    Science.gov (United States)

    Yagmurcukardes, M.; Bacaksiz, C.; Senger, R. T.; Sahin, H.

    2017-09-01

    By performing density functional theory-based calculations, we investigate how structural, electronic and mechanical properties of single layer ReS2 can be tuned upon hydrogenation of its surfaces. It is found that a stable, fully hydrogenated structure can be obtained by formation of strong S-H bonds. The optimized atomic structure of ReS2H2 is considerably different than that of the monolayer ReS2 which has a distorted-1T phase. By performing phonon dispersion calculations, we also predict that the Re2-dimerized 1T structure (called 1T {{}\\text{R{{\\text{e}}2}}} ) of the ReS2H2 is dynamically stable. Unlike the bare ReS2 the 1T {{}\\text{R{{\\text{e}}2}}} -ReS2H2 structure which is formed by breaking the Re4 clusters into separated Re2 dimers, is an indirect-gap semiconductor. Furthermore, mechanical properties of the 1T {{}\\text{R{{\\text{e}}2}}} phase in terms of elastic constants, in-plane stiffness (C) and Poisson ratio (ν) are investigated. It is found that full hydrogenation not only enhances the flexibility of the single layer ReS2 crystal but also increases anisotropy of the elastic constants.

  12. Res Publica jäi järjekordselt ilma mitmest nimekast liikmest / Tuuli Koch, Kärt Anvelt

    Index Scriptorium Estoniae

    Koch, Tuuli

    2005-01-01

    Oma lahkumiset Res Publicast teatasid erakonna esimene esimees Rein Taagepera, tema abikaasa Mare Taagepera, akadeemik Jaan Einasto ja 2002. aastal erakonna esimeheks kandideerinud Lauri Aaspõllu. Rein Taagepera põhjendas otsust Res Publica liikumisega paremtsentrist paremäärmusse. Lisa: Tuntud inimesi, kes seni Res Publicast lahkunud. Vt. samas lühiintervjuud Jaan Einastoga: Res Publica peab tegema koostööd

  13. Gestão integrada de resíduos : o impacto ambiental

    OpenAIRE

    Oliveira, Rosário

    2004-01-01

    Faz-se uma introducão à politica de gestão integrada de resíduos para enquadrar a valorização de resíduos como política desejável para assegurar um desenvolvimento sustentado. Referem-se de seguida metodologias para avaliação do impacto ambiental da utilização de resíduos que possam ser usados como materiais de construção civil e obras públicas, ressalvando-se alguma falta de enquadramento legal.

  14. Dynamique de fréquentation des grands mammifères dans une ...

    African Journals Online (AJOL)

    SARAH

    31 juil. 2016 ... RÉSUMÉ. Objectifs : Dans le but de connaitre les animaux fréquentant les clairières (ou Baï) forestières au Gabon, une étude sur la fréquentation du Baï de Momba par les grands mammifères a été conduite durant la petite saison des pluies pendant deux mois du 19 février au 13 mars 2012. Méthodologie ...

  15. Res Publicat on täna vaja rohkem kui kunagi varem / Taavi Veskimägi

    Index Scriptorium Estoniae

    Veskimägi, Taavi, 1974-

    2005-01-01

    Res Publica esimees seab erakonnale ülesandeks selgitada inimestele, et Res Publicat võib usaldada. Ta selgitab, et Res Publica parempoolne poliitika tähendab ka hoolimist nendest, kes ei saa endaga hakkama. Vt. samas: Viimased kampaaniapäevad

  16. Diagnóstico dos resíduos sólidos do setor agrossilvopastoril : resíduos sólidos inorgânicos

    OpenAIRE

    Rosseto, Renato

    2013-01-01

    Este trabalho buscou realizar o diagnóstico preliminar dos resíduos sólidos inorgânicos gerados no setor agrossilvopastoril, especialmente nos segmentos de agrotóxicos, fertilizantes, insumos farmacêuticos veterinários, além dos resíduos sólidos domésticos (RSDs) rurais Os assuntos foram separados em seções. De forma geral, a ausência de informações oficiais sistematizadas seguiu como a principal dificuldade em realizar o diagnóstico dos resíduos sólidos inorgânicos presentes no setor agrossi...

  17. Using the renewable energy sources in the market conditions

    International Nuclear Information System (INIS)

    Kozlov, V.B.

    2000-01-01

    Raper studies the peculiarities of financing of projects for the renewable energy sources (RES) in cooperation with the Kyoto protocol as to the regulating principles of purchase (sale) of quotas for greenhouse gas release. The records of the results obtained in the West European countries and USA as to payment of green electricity generated on the basis of RES application is analyzed. Preliminary estimation of cost ratio of quotas for releases of greenhouse gases for conventional power plants and RES based ones is presented [ru

  18. Declining prevalence of cytological squamous intraepithelial lesions of the cervix among women living with well-controlled HIV - Most women living with HIV do not need annual PAP smear screening.

    Science.gov (United States)

    Aho, Inka; Kivelä, Pia; Haukka, Jari; Sutinen, Jussi; Heikinheimo, Oskari

    2017-11-01

    Cervical screening by means of annual Papanicolaou (PAP) smears has been recommended for all women living with HIV. We analysed the results of our annual PAP smear screening program to identify low-risk subgroups for less rigorous screening. The study comprised 369 women followed at the Helsinki University Hospital 2002-2013, with a total of 2033 PAP smear results. We analyzed the temporal changes in PAP smear findings. Logistic regression analysis for binominal dependent variables was used for assessing risk factors for ever having cytological squamous intraepithelial lesions (hereafter referred as SIL) using generalized estimating equations taking into account multiple observations of each patient. Most women had well-controlled HIV, especially towards the end of the study. PAP smear results improved substantially. At the time of each individual's last PAP smear, 90.0% of the findings displayed normal results. Conversely, the rate of SIL decreased from 16.8% to 4.6% from 2002 to 2013. In multivariate analysis the risk of SIL was significantly lower in women with consecutive normal PAP smear findings during the first two years of follow up [odds ratio (OR) 0.21, 95% confidence interval (CI) 0.10-0.45, p 500 cells/μL (OR 0.11, 95% CI 0.05-0.26, p < 0.001). Widespread use of combination antiretroviral therapy (cART) and systematic cervical screening has reduced the rate of abnormal PAP smears. It seems feasible to identify low-risk women by combining HIV-related information and PAP smear results. Screening low-risk women living with HIV at three-year intervals similar to HIV-negative women appears justified. © 2017 Nordic Federation of Societies of Obstetrics and Gynecology.

  19. Res Publica ja Isamaaliit ühendavad jõud / Urmo Kübar, Rauno Veri

    Index Scriptorium Estoniae

    Kübar, Urmo, 1978-

    2006-01-01

    Res Publica esimees Taavi Veskimägi ja Isamaaliidu esimees Tõnis Lukas kirjutasid alla ühiste kavatsuste deklaratsioonile, milles nad teevad ettepaneku moodustada ühine erakond. Lisad: Erakonna Eesti Eest deklaratsioon; Lühiülevaade ajaloost

  20. Res Publica üldkogu hääletab poliitilisi resolutsioone / Lauri Tankler

    Index Scriptorium Estoniae

    Tankler, Lauri

    2004-01-01

    Res Publica üldkogul hääletusele pandavate resolutsioonide eesmärgiks on teavitada avalikkust erakonna seisukohtadest. Olulisemad resolutsioonid on ette valmistatud ideoloogia, majanduse, hariduse ja sotsiaalpoliitika valdkonnas

  1. Res Publica nõuab Leinatammelt 44 600 krooni / Kadri Jakobson

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2005-01-01

    Res Publica nõuab Reformierakonda üle läinud Tarmo Leinatammelt maksmata jäänud liikmemaksu, fraktsioon kutsub teda üles loobuma kohast Riigikogus. Erakonna pressiesindaja Riina Vändre selgitus

  2. Res Publica tahab muuta Riigikogu kuluhüvitiste süsteemi / Alari Rammo

    Index Scriptorium Estoniae

    Rammo, Alari

    2003-01-01

    Riigikogu Res Publica fraktsiooni ettepanekutest reformida Riigikogu liikmetele ette nähtud kuluhüvitiste süsteemi. Tabel: Kasutatud kuluhüvitised seisuga 15. oktoober 2003. Kommenteerib Urmo Kübar

  3. Promotion of renewable energy sources in Romania

    International Nuclear Information System (INIS)

    Turcu, Ioan

    2005-01-01

    Romania's climate and geographical conditions offer the following types of renewable energy sources: solar energy, wind energy, hydro energy, biomass and geothermal energy. These are here considered within the country's energy balance on medium and long term. Romania has a significant renewable energy potential. Unfortunately at present this potential is not used but to a small extent, except for hydraulic energy and biomass (especially as firewood), the latter being used in the great majority of cases in low performance installations. Government Decision No. 443/2003 on the promotion of electric energy generation from RES and Government Decision No. 1535/2003 regarding the Strategy of RES, establish the legal framework necessary for the promotion of RES in Romania. Consequently, an Action Plan defining actions, measures, responsibilities and financial sources has been settled. (author)

  4. The Escherichia coli P and Type 1 Pilus Assembly Chaperones PapD and FimC Are Monomeric in Solution

    Energy Technology Data Exchange (ETDEWEB)

    Sarowar, Samema; Hu, Olivia J.; Werneburg, Glenn T.; Thanassi, David G.; Li, Huilin; Christie, P. J.

    2016-06-27

    ABSTRACT

    The chaperone/usher pathway is used by Gram-negative bacteria to assemble adhesive surface structures known as pili or fimbriae. Uropathogenic strains ofEscherichia coliuse this pathway to assemble P and type 1 pili, which facilitate colonization of the kidney and bladder, respectively. Pilus assembly requires a periplasmic chaperone and outer membrane protein termed the usher. The chaperone allows folding of pilus subunits and escorts the subunits to the usher for polymerization into pili and secretion to the cell surface. Based on previous structures of mutant versions of the P pilus chaperone PapD, it was suggested that the chaperone dimerizes in the periplasm as a self-capping mechanism. Such dimerization is counterintuitive because the chaperone G1 strand, important for chaperone-subunit interaction, is buried at the dimer interface. Here, we show that the wild-type PapD chaperone also forms a dimer in the crystal lattice; however, the dimer interface is different from the previously solved structures. In contrast to the crystal structures, we found that both PapD and the type 1 pilus chaperone, FimC, are monomeric in solution. Our findings indicate that pilus chaperones do not sequester their G1 β-strand by forming a dimer. Instead, the chaperones may expose their G1 strand for facile interaction with pilus subunits. We also found that the type 1 pilus adhesin, FimH, is flexible in solution while in complex with its chaperone, whereas the P pilus adhesin, PapGII, is rigid. Our study clarifies a crucial step in pilus biogenesis and reveals pilus-specific differences that may relate to biological function.

    IMPORTANCEPili are critical virulence factors for many bacterial pathogens. UropathogenicE. colirelies on P and type 1 pili assembled by the chaperone/usher pathway to

  5. Rationales for technology-specific RES support and their relevance for German policy

    International Nuclear Information System (INIS)

    Gawel, Erik; Lehmann, Paul; Purkus, Alexandra; Söderholm, Patrik; Witte, Katherina

    2017-01-01

    In order to achieve cost-effective RES-E deployment it is often argued that technology-neutral support schemes for renewables are indispensable. Against this background, RES-E support policies making widely use of technology differentiation in remuneration settings, e.g. across the EU, are frequently criticized from a theoretical point of view. However, in this paper we provide a systematic critique of the technology neutrality concept as a foundation for designing policy support schemes in the RES-E technology field. Specifically, the main objective of the paper is to scrutinize the arguments for technology-neutrality, and discuss three conceptual arguments for why technology-specific support schemes could in fact help minimize the societal costs of reaching future RES-E targets. We also briefly address different political economy concerns, which could constrain the choice of cost-effective policy support schemes, and that have to be taken into account for economic policy advice. For empirical illustration of the key arguments we refer to the case of German RES-E policy-making. The central conclusion from this paper is that technology-specific RES-E support schemes may generate significant economic benefits, particularly if technology markets work imperfectly and in second-best policy settings with additional non-internalized market failures. - Highlights: • Three theoretical cost-effectiveness reasons for technology-specific RES-E support. • German case study to show relevance of theoretical arguments for policy-making. • Political economy constraints to technology-neutral support are demonstrated. • Technology-specific RES-E support may generate significant economic benefits.

  6. Comment rendre les villes plus sûres | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    29 oct. 2015 ... À mi-chemin d'un programme quinquennal de recherche, les experts qui travaillent à l'initiative Villes sûres et inclusives font la lumière sur ce qui fonctionne – et ne fonctionne pas – pour rendre les villes plus sûres. Le présent compte rendu présente certains enseignements tirés de leur travail, ainsi que ...

  7. Ressources minières en Afrique : Quelle réglementation pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ressources minières en Afrique : Quelle réglementation pour le développement ? Couverture du livre Ressources minières en Afrique : Quelle réglementation pour le développement ? Directeur(s):. Bonnie Campbell. Maison(s) d'édition: Presses de l'Université du Québec, CRDI. 6 juillet 2009. ISBN : 9782760525214.

  8. The performances of standard and ResMed masks during bag-valve-mask ventilation.

    Science.gov (United States)

    Lee, Hyoung Youn; Jeung, Kyung Woon; Lee, Byung Kook; Lee, Seung Joon; Jung, Yong Hun; Lee, Geo Sung; Min, Yong Il; Heo, Tag

    2013-01-01

    A tight mask seal is frequently difficult to obtain and maintain during single-rescuer bag-valve-mask (BVM) ventilation. The ResMed mask (Bella Vista, NSW, Australia) is a continuous-positive-airway-pressure mask (CM) designed for noninvasive ventilation. In this study, we compared the ventilation performances of a standard mask (SM) and a ResMed CM using a simulation manikin in an out-of-hospital single-rescuer BVM ventilation scenario. Thirty emergency medical technicians (EMTs) performed two 2-minute attempts to ventilate a simulation manikin using BVM ventilation, alternatively, with the SM or the ResMed CM in a randomized order. Ventilation parameters including tidal volume and peak airway pressure were measured using computer analysis software connected to the simulation manikin. Successful volume delivery was defined as delivery of 440-540 mL of tidal volume in accord with present cardiopulmonary resuscitation guidelines. BVM ventilation using the ResMed CM produced higher mean (± standard deviation) tidal volumes (452 ± 50 mL vs. 394 ± 113 mL, p = 0.014) and had a higher proportion of successful volume deliveries (65.3% vs. 26.7%, p < 0.001) than that using the SM. Peak airway pressure was higher in BVM ventilation using the ResMed CM (p = 0.035). Stomach insufflation did not occur during either method. Twenty-nine of the participants (96.7%) preferred BVM ventilation using the ResMed CM. BVM ventilations using ResMed CM resulted in a significantly higher proportion of successful volume deliveries meeting the currently recommended range of tidal volume. Clinical studies are needed to determine the value of the ResMed CM for BVM ventilation.

  9. Isamaa ja Res Publica liit tõotab neile kõrget kohta edetabelis / Rasmus Kagge

    Index Scriptorium Estoniae

    Kagge, Rasmus, 1977-

    2006-01-01

    Ilmunud ka: Postimees : na russkom jazõke 10. apr. lk. 7. TNS Emori märtsikuu erakondade populaarsusuuringu tulemused näitavad, et Res Publicaga liituda otsustanud Isamaaliit on tõusnud poliitedetabelis kolmandale kohale. Res Publica reiting on endiselt madal, edetabelit juhib Keskerakond. Diagrammid: Isamaaliit kogub toetajaid tõusvas tempos. Vt. samas: Ühendpartei Eesti Eest! otsib endale uut nime

  10. Error-prone bypass of O6-methylguanine by DNA polymerase of Pseudomonas aeruginosa phage PaP1.

    Science.gov (United States)

    Gu, Shiling; Xiong, Jingyuan; Shi, Ying; You, Jia; Zou, Zhenyu; Liu, Xiaoying; Zhang, Huidong

    2017-09-01

    O 6 -Methylguanine (O 6 -MeG) is highly mutagenic and is commonly found in DNA exposed to methylating agents, generally leads to G:C to A:T mutagenesis. To study DNA replication encountering O 6 -MeG by the DNA polymerase (gp90) of P. aeruginosa phage PaP1, we analyzed steady-state and pre-steady-state kinetics of nucleotide incorporation opposite O 6 -MeG by gp90 exo - . O 6 -MeG partially inhibited full-length extension by gp90 exo - . O 6 -MeG greatly reduces dNTP incorporation efficiency, resulting in 67-fold preferential error-prone incorporation of dTTP than dCTP. Gp90 exo - extends beyond T:O 6 -MeG 2-fold more efficiently than C:O 6 -MeG. Incorporation of dCTP opposite G and incorporation of dCTP or dTTP opposite O 6 -MeG show fast burst phases. The pre-steady-state incorporation efficiency (k pol /K d,dNTP ) is decreased in the order of dCTP:G>dTTP:O 6 -MeG>dCTP:O 6 -MeG. The presence of O 6 -MeG at template does not affect the binding affinity of polymerase to DNA but it weakened their binding in the presence of dCTP and Mg 2+ . Misincorporation of dTTP opposite O 6 -MeG further weakens the binding affinity of polymerase to DNA. The priority of dTTP incorporation opposite O 6 -MeG is originated from the fact that dTTP can induce a faster conformational change step and a faster chemical step than dCTP. This study reveals that gp90 bypasses O 6 -MeG in an error-prone manner and provides further understanding in DNA replication encountering mutagenic alkylation DNA damage for P. aeruginosa phage PaP1. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Biossorção de azul de metileno utilizando resíduos agroindustriais

    Directory of Open Access Journals (Sweden)

    Andressa C. Honorato

    2015-07-01

    Full Text Available O presente trabalho avaliou a capacidade de adsorção do corante azul de metileno nos resíduos da palha de milho e da bainha do palmito pupunha in natura. A caracterização dos resíduos foi determinada utilizando-se a microscopia eletrônica de varredura e espectroscopia na região do infravermelho a qual indicou a presença de grupos carboxílicos, hidroxila e carbonila. O tempo necessário para que o sistema atingisse o equilíbrio para ambos os resíduos foi de 240 min, seguindo uma cinética descrita pelo modelo de pseudo-segunda ordem. A capacidade máxima de adsorção foi de 102,8 mg g-1 para o resíduo da palha de milho, seguindo o modelo de isoterma de Langmuir e 50,9 mg g-1 para o resíduo de palmito pupunha, sendo que o modelo que melhor se ajusta foi Freundlich. Desta forma, esses resíduos são promissores para a adsorção do corante azul de metileno em efluentes.

  12. Revisiting long-run relations in power markets with high RES penetration

    International Nuclear Information System (INIS)

    Gianfreda, Angelica; Parisio, Lucia; Pelagatti, Matteo

    2016-01-01

    Electricity generation from renewable energy resources (RES) has become increasingly significant to reach EU and emissions reduction targets. At the same time, one of the main EU policy goals has been the creation of a common internal energy market for Europe. In this paper, we focus on these two issues previously studied separately, considering their possible interactions. We first analyze the long-run relationship between day-ahead electricity prices and fuel prices (natural gas and coal) looking at two samples of years characterized by low and high RES penetration, then we explore the integration of EU markets. We show that the electricity–fuel nexus found over 2006–2008 changed dramatically over 2010–2014 for the majority of countries considered. In particular, the long-run dependence of electricity from gas and coal prices is much lower in recent years. Furthermore, our results confirm that the considered EU countries are becoming less integrated as RES-E increases. Our findings suggest that nationally implemented policies to support renewables are successful in increasing RES penetration, but they have lessened the linkage among EU markets, then making integration more difficult to obtain. - Highlights: •RES lower the intra-daily electricity dependence from coal and natural gas. •RES affect the EU wholesale electricity market integration, studied at hourly level. •Overlapping national and supranational policies tackle the achievement of EU targets. •Strong policy coordination is required to avoid that the “greens” promote the “dirtiest”.

  13. Mastery of Content Representation (CoRes) Related TPACK High School Biology Teacher

    Science.gov (United States)

    Nasution, W. R.; Sriyati, S.; Riandi, R.; Safitri, M.

    2017-09-01

    The purpose of this study was to determine the mastery of Content Representation (CoRes) teachers related to the integration of technology and pedagogy in teaching Biology (TPACK). This research uses a descriptive method. The data were taken using instruments CoRes as the primary data and semi-structured interviews as supporting data. The subjects were biology teacher in class X MIA from four schools in Bandung. Teachers raised CoRes was analyzed using a scoring rubric CoRes with coding 1-3 then categorized into a group of upper, middle, or lower. The results showed that the two teachers in the lower category. This results means that the control of teachers in defining the essential concept in the CoRes has not been detailed and specific. Meanwhile, two other teachers were in the middle category. This means that the ability of teachers to determine the essential concepts in the CoRes are still inadequate so that still needs to be improved.

  14. Epitaxial growth of ReS2(001) thin film via deposited-Re sulfurization

    Science.gov (United States)

    Urakami, Noriyuki; Okuda, Tetsuya; Hashimoto, Yoshio

    2018-02-01

    In this paper, we present the formation of large-size rhenium disulfide (ReS2) films via the sulfurization of Re films deposited on sapphire substrates. The effects of sulfurization temperature and pressure on the crystal quality were investigated. A [001]-oriented single crystal of ReS2 films with 6 × 10 mm2 area was realized. By sulfurizing Re films at 1100 °C, ReS2 films with well-defined sharp interfaces to c-plane sapphire substrates could be formed. Below and above the sulfurization temperature of 1100 °C, incomplete sulfurization and film degradation were observed. The twofold symmetry of the monocrystalline in-plane structure composed of Re-Re bonds along with Re-S bonds pointed to a distorted 1T structure, indicating that this structure is the most stable atomic arrangement for ReS2. For a S/Re compositional ratio equal to or slightly lower than 2.0, characteristic Raman vibrational modes with the narrowest line widths were observed. The typical absorption peak of ReS2 can be detected at 1.5 eV.

  15. The promotion in Romania of electricity from renewable energy sources - present and future

    International Nuclear Information System (INIS)

    Stanciulescu, Georgeta; Popescu, Mihaela; Caracasian, Lusine; Anton, Bogdan

    2004-01-01

    The paper deals with the present situation and prospects of electricity generation from renewable energy sources in Romania. The following subject matters are addressed: Legal framework; - Regulatory framework; - Ministry of Economy and Commerce - competence and responsibilities; - ANRE - competence and responsibilities; - Targets by 2010; - Benefits of Electricity from RES; - Costs, by technology, for E-RES; - Renewable support mechanisms; - RES, technical and economical potential for Romania; - Sensitivity Analysis. In conclusion, one stresses that the existing legal and regulatory framework which sets up responsibilities and dead lines regarding the promotion of E-RES and it's access on the market: - ensures a transparent, nondiscriminatory and objective treatment for the E-RES producers; - gives some facilities concerning the authorization process and ensures the take over of the electricity produced from renewable sources to the national grid; -sets up state aids granting conditions for investments and operation of the renewable energy sources; - requires some improvements regarding the financial support for promoting E-RES, guarantee of origin and trade. Depending on the chosen support scheme, the institutional framework will be developed in order to comply with the legal requirements and dead-lines. The technologies for E-RES generation will be implemented depending on: - the RES potential; - the commercial maturity of the technology, i.e. the technologies implied in hydro, wind, biomass, solar, waves and tide energy generation

  16. ["Where there's a woman, there's a Pap smear": the meanings assigned to cervical cancer prevention among women in Salvador, Bahia State, Brazil].

    Science.gov (United States)

    Rico, Ana María; Iriart, Jorge Alberto Bernstein

    2013-09-01

    This study focuses on the meanings assigned to practices for cervical cancer prevention among women from low-income neighborhoods in Salvador, Bahia State, Brazil. This was a qualitative study based on content analysis of semi-structured interviews with 15 women 24 to 68 years of age. The results showed high appreciation of the Pap smear test, performed as part of routine gynecological examination (but without the patient necessarily having biomedical knowledge of its role). Besides accessibility and quality of health services, other factors influence the way the women assign meaning to cervical cancer prevention. Moral values associated with sexuality and gender influence risk perception, adoption of preventive practices, and interpretation of cervical cytology results. The ongoing practice of the Pap smear test is part of the construction of femininity, which is associated with maturity and personal responsibility for self care in a context of medicalization of the female body.

  17. COMPUTER AIDED DIAGNOSIS FOR DETECTION AND STAGE IDENTIFICATION OF CERVICAL CANCER BY USING PAP SMEAR SCREENING TEST IMAGES

    Directory of Open Access Journals (Sweden)

    S. Athinarayanan

    2016-05-01

    Full Text Available The majority of the women of the world were affected by the disease of cervical cancer. As a result of this disease, their death rate was increase as hasty level. Hence so many number of research people was focused this notion as their research interest and also they have done so many number of solutions for finding this cancer by using some image processing technique and achieved a good results only in advanced and high cost techniques of LBC, biopsy or Colposcopy test Images. Therefore the reason, the authors have chosen this problem and also did not only to find whether the patient is affected by a cancer or not. In addition to the patient was affected by this cancer means and also to identify which severity stage of this disease the patient could be live. Then this work has done in based on the images of low cost pap smear screening test by using various image processing techniques with the help of Computerized Image Processing Software Interactive Data Language (IDL-Image Processing Language. Thus the final reports would be very useful to the pathologists for further analysis.

  18. A construção social dos papéis sexuais femininos Feminine sex-roles social construction

    Directory of Open Access Journals (Sweden)

    Eros DeSouza

    2000-01-01

    Full Text Available Esta revisão é uma tentativa de produzir uma representação holística, mas não exaustiva, dos papéis sexuais femininos no Brasil. Começamos traçando o papel histórico-político das mulheres do Brasil Colonial até o movimento feminista moderno, enfocando três questões correntes: planejamento familiar, creches e violência contra a mulher. A seguir, examinamos as normas culturais do machismo e do marianismo. Finalmente, discutimos os avanços que as mulheres fizeram no Brasil na última década (desde a Constituição de 1988, chamando a atenção para uma questão que tem sido grandemente ignorada: o assédio sexual.This review is an attempt to provide a holistic, but by no means exhaustive, picture of gender roles in Brazil. We begin by tracing the historical-political role of women from colonial Brazil through the modern women’s movement, highlighting three current issues: family planning, child care, and violence against women. Next, we examine the cultural norms of machismo and marianismo. Finally, we discuss the strides women have made in Brazil in the last decade (since the Consitution of 1988, calling attention to one issue that has been largely ignored: sexual harassment.

  19. Knowledge, attitude and practice of cervical cancer screening (pap smear) among female nurses in Nnewi, South Eastern Nigeria.

    Science.gov (United States)

    Udigwe, G O

    2006-06-01

    To determine the knowledge and practice of cervical cancer screening among practicing female nurses with a view to sensitizing them as a first step towards increasing screening uptake in the community. A self administered questionnaire survey of all the female nurses working in Nnamdi Azikiwe university Teaching Hospital Nnewi center. 144 out of 166 questionnaires were correctly completed and returned. 122 (87%) were aware of the existence of screening services. Although 9.3% had lost relations to cancer of the cervix, only 5.7% had ever undergone a pap smear. While 52 (37.1%) had no reason for not screening, 21 (15%) were afraid of the possible outcome and 35 (25%) felt they were not likely candidates for cancer of the cervix. knowledge of cervical cancer screening services among female nurses in Nnewi is high while uptake rate is abysmally poor. There is need to further educate the nurses who will play a major role in enlightening the public on the availability and need for cervical screening services.

  20. Low-cost fabrication and performance testing of Polydimethylsiloxane (PDMS) micromixers using an improved print-and-Peel (PAP) method

    Science.gov (United States)

    Abagon, Ma. Victoria; Buendia, Neil Daniel; Jasper Caracas, Corine; July Yap, Kristian

    2018-03-01

    The research presents different configurations of microfluidic mixers made from polydimethylsiloxane (PDMS) fabricated using an improved, low-cost print-and-peel (PAP) method. Processes, such as mixing, operated in the micro scale allow decreased equipment size-to-production capacity ratio and decreased energy consumption per unit product. In the study, saturated solutions of blue and yellow food dyes were introduced inside the channels using a LEGO® improvised microsyringe pump. Scanning Electron Microscopy (SEM) was used to determine the average depth of the fabricated micromixers which was found to be around 14 ¼m. The flows were observed and images were taken using a light microscope. The color intensities of the images were then measured using MATLAB®. From the relationship between color intensity and concentration, the mixing indices were calculated and found to be 0.9435 to 0.9941, which falls within the standard mixing index range (0.8 - 1.0) regardless of the flow rate and the configuration of the micromixer as verified through the two-way ANOVA. From the cost analysis, the cost of the device fabricated in this study is a hundred-fold less than expenses from standard fabrication procedures. Hence, the fabricated device provides an alternative for micromixers produced from expensive and conventional lithographic methods.

  1. The Effect of an Educational Program Based on Protection Motivation Theory on Pap Smear Screening Behavior among Women Referring to Health Centers in Fasa

    Directory of Open Access Journals (Sweden)

    Zahra Khiyali

    2017-03-01

    Full Text Available Background and Objectives: Despite the importance of pap smear in reducing the incidence of cervical cancer and its death, this cancer is still one of the leading causes of death among women around the world. Accordingly, in this study, we aimed to determine the effect of an educational program based on the protection motivation theory on Pap smear screening behavior. Materials and Methods: This quasi-experimental study was conducted on 200 women referring to Fasa health centers, Fasa, Iran. The participants were randomized into experimental and control groups (n=100 per group. The data collection tool, which consisted of demographic data and protection motivation theory constructs, was completed by both groups before and 2 months after the intervention. For the experimental group, the educational program was implemented during 4 sessions using group discussions and educational pamphlets. To analyze the data, chi-square test, independent t-test, and paired t-test were run in SPSS, version 22. Results: After the intervention, the mean scores of protection motivation theory constructs significantly increased in the experimental group compared to the control group (P<0.001. However, no significant difference was noted between the two groups regarding the response efficacy construct at the post-intervention stage (P=0.552. In addition, after the intervention, the rate of conducting Pap smear test significantly incremented in the experimental group (58%. Conclusions: The study results revealed the effectiveness of the educational intervention based on protection motivation theory in promoting Pap smear screening behavior. Therefore, we recommend designing educational interventions based on this theory to promote public health, especially in women.

  2. Factors affecting compliance with clinical practice guidelines for pap smear screening among healthcare providers in africa: systematic review and meta-summary of 2045 individuals.

    Directory of Open Access Journals (Sweden)

    Etienne Asonganyi

    Full Text Available Although the importance of the Pap smear in reducing cancer incidence and mortality is known, many countries in Africa have not initiated yet widespread national cervical cancer screening programs. The World Health Organization (WHO has published Clinical Practice Guidelines (CPGs on cervical cancer screening in developing countries; however, there is a gap between expectations and clinical performance. Thus, the aim of this study was to conduct a systematic review and meta-summary to identify factors affecting compliance with CPGs for Pap screening among healthcare providers in Africa.And Findings: MEDLINE, Scirus, Opengate and EMBASE databases were searched in January 2012. Studies involving medical personnel practicing in Africa, whose outcome measured any factors that affect medical personnel from using a Pap smear to screen for cervical cancer, were included. Two reviewers independently evaluated titles and abstracts, then full-texts, extracted data and assessed quality of the included studies. A descriptive analysis of the included studies was conducted. We calculated Frequency effect sizes (FES for each finding and Intensity effect sizes (IES for each article to represent their magnitudes in the analyses. Of 1011 studies retrieved, 11 studies were included (2045 individuals. Six different themes related to the factors affecting compliance with CPGs were identified: Insufficient Knowledge/Lack of awareness (FES = 82%, Negligence/Misbeliefs (FES = 82%, Psychological Reasons (FES = 73%, Time/Cost Constraint (FES = 36%, Insufficient infrastructure/training (FES = 45% and also no reason given (FES = 36%. IES for articles ranged between 33 and 83%.These results suggest that prevention initiatives should be comprehensive to include education and resources needs assessments and improvement, Pap smear test training, strategies on costing, and practitioner time studies.

  3. Tobacco expressing pap1 increases the responses to par and uv-a by enhancing soluble sugars and flavonoids and elevating plant protections

    International Nuclear Information System (INIS)

    Sompornpailin, K.; Kanthang, S.

    2015-01-01

    Five lines of transgenic tobacco over-expressing Production of Anthocyanin Pigment 1 (PAP1) cDNA were analysis of metabolic response against the radiation and their protection of the plant under tissue culture condition. PAP1 transgenic and wild type (WT) plants were treated with the radiations of photosynthetically activate radiation (PAR) or PAR combined with UV-A. All lines of transgenic significantly increased in amounts of p-coumaric acid, naringenin apigenin more than WT under both treatments. Additional UV-A radiating to plant rose up kaempferol content in WT plant (1.5 times) and in PAP1 transgenics (1.8 times). These transgenic plants treated under both conditions had also increased anthocyanin substances (pelargonidin) with significant value after compared to WT. Content of total soluble sugar (TSS) was related to the content of total flavonoids in transgenic. PAR combined with UV-A had a lower induction of the electrolyte leakage percentage and malondialdehyde (MDA) level in the transgenic leaf tissue compared to WT tissue. The metabolic substance levels were considered on its protection of plant cells. In transgenic tissue, the enhancement of apigenin level strongly diminished the increase level of electrolyte leakage while the levels of TSS, p-coumaric acid and naringinin less affected. Moreover, the increase levels of kaempferol and pelargonidin associated with the decrease level of MDA, while the TSS level reversely responded. The PAP1 transgenic increased response of light by adaptation of their metabolites (TSS, p-coumaric acid and flavonoids) consequently enhance parameter indicating protections of the cell. (author)

  4. Short term evaluation of respiratory effort by premature infants supported with bubble nasal continuous airway pressure using Seattle-PAP and a standard bubble device

    Science.gov (United States)

    Welty, Stephen E.; Rusin, Craig G.; Stanberry, Larissa I.; Mandy, George T.; Gest, Alfred L.; Ford, Jeremy M.; Backes, Carl H.; Richardson, C. Peter; Howard, Christopher R.; Hansen, Thomas N.

    2018-01-01

    Background Almost one million prematurely born infants die annually from respiratory insufficiency, predominantly in countries with limited access to respiratory support for neonates. The primary hypothesis tested in the present study was that a modified device for bubble nasal continuous positive airway pressure (Bn-CPAP) would provide lower work of spontaneous breathing, estimated by esophageal pressure-rate products. Methods Infants born CPAP with FiO2 CPAP, then 2 h with Bn-CPAP using a modified bubble device presently termed Seattle-PAP, which produces a different pattern of pressure fluctuations and which provided greater respiratory support in preclinical studies, then 2 h on standard Bn-CPAP. Results All 40 infants enrolled completed the study and follow-up through 36 wks post menstrual age or hospital discharge, whichever came first. No infants were on supplemental oxygen at completion of follow-up. No infants developed pneumothoraces or nasal trauma, and no adverse events attributed to the study were observed. Pressure-rate products on the two devices were not different, but effort of breathing, assessed by areas under esophageal pressure-time curves, was lower with Seattle-PAP than with standard Bn-CPAP. Conclusion Use of Seattle-PAP to implement Bn-CPAP lowers the effort of breathing exerted even by relatively healthy spontaneously breathing premature neonates. Whether the lower effort of breathing observed with Seattle-PAP translates to improvements in neonatal mortality or morbidity will need to be determined by studies in appropriate patient populations. PMID:29590143

  5. A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology

    Directory of Open Access Journals (Sweden)

    Zappacosta R

    2014-04-01

    Full Text Available Roberta Zappacosta,1 Giuseppe Lattanzio,2 Patrizia Viola,2 Manuel Maria Ianieri,3 Daniela Maria Pia Gatta,1 Sandra Rosini11Cytopathology Unit, Experimental and Clinical Sciences Department, Gabriele d’Annunzio University of Chieti-Pescara, Chieti, Italy; 2Surgical Pathology Unit, 3Obstetrics and Gynecology Unit, SS Annunziata Hospital, Chieti, ItalyAbstract: The introduction of organized cervical cancer (CC screening programs has drastically reduced the prevalence of CC. However the incidence is still too high, especially among elderly women. All guidelines strongly recommend a regular Papanicolaou (Pap testing for young and middle-aged patients. On the other hand, many international professional societies no longer advise screening in women who have undergone hysterectomy, and in women aged 65 years and above, who have a previous history of regular Pap smears. Here we report the case of poorly differentiated CC, involving the pelvic lymph nodes and urinary bladder, occurring in a 79-year-old woman who regularly underwent Pap tests, with no reported cytological abnormalities. In this very rare case, the CC cells, as well as cells from metastatic lymph nodes and cells from urinary specimens, molecularly showed human papilloma virus (HPV-53. With the limitations of a single case, this report brings important information to prevent CC in elderly patients: the utility of molecular tests to increase sensitivity of Pap smears in postmenopausal women; the importance of HPV-53 as one of the four “emergent” genotypes having a possible role in oncogenesis; and the presence of HPV-53 in lymph node metastases from cervical carcinoma, which would support the role of this virus in the maintenance of malignant status.Keywords: old women, molecular tests, cervical cancer screening, HPV-DNA test, HPV genotypingA Letter to the editor has been received and published for this articleCorrigendum for this paper has been published

  6. The Theos/ComRes survey into public perception of Darwinism in the UK: a recipe for confusion.

    Science.gov (United States)

    Baker, Sylvia

    2012-04-01

    A survey of the general public in the UK, conducted in 2008, suggested that more than half of the British population are unconvinced by Darwinism. That survey, conducted by the polling company ComRes on behalf of the theological think-tank Theos, reported its full findings in March 2009 and found them to be "complex and confused." This paper argues that the confusion identified may have been partly engendered by the way in which the survey questionnaire was constructed and that the survey itself, not simply its respondents, was confused. A source of the confusion, it is argued, could be found, first, in the definitions used for the four positions of young earth creationism, theistic evolution, atheistic evolution and intelligent design. Second, a failure to define the key terms "evolution" and "science," used in some of the survey questions, resulted in responses that were difficult to interpret.

  7. Pap smear cytology and identification of Human Papillomavirus (HPV) type 16 and 18 in multiparity women at Aviati Clinic Padang Bulan Medan

    Science.gov (United States)

    Anggraini, D. R.; Feriyawati, L.; Fitrie, A. A.; Ginting, R. N. A.

    2018-03-01

    Cervical cancer is the second most frequent cancer in woman in developing countries and one of the most crucial health problems in the world. Human Papillomavirus (HPV) is an agent for sexually transmitted disease which is an act of cervical cancer, especially high-risk of HPV type 16 and 18. In this study, we investigated the Pap smear cytology features and identification of HPV types 16 and18 in multiparity women at Aviati Clinic Padang Bulan, Medan. Samples are cervical swabs of 50 multiparity women who met the inclusion criteria (childbirth ≥ three times) was included in the study. Pap smear examination was conducted using Papanicolaou staining and identification of HPV types 16 and 18 using the Polymerase Chain Reactive (PCR) methods. Pap smearcytology showed 80% Negative for intraepithelial lesion or malignancy (NILM) with inflammation and 20% NILM. The result of PCR amplification showed that there weren’t specific band DNA was found at band 414bp and 216bp. That means there weren’t cervical swabs sample had DNA of HPV type 16 and 18.

  8. Papéis sociais no ensino superior: aluno-cliente, professor-gerente-educador, instituição de ensino-mercantil

    Directory of Open Access Journals (Sweden)

    Cassia Helena Pereira Lima

    2006-07-01

    Full Text Available O objetivo deste artigo é fornecer subsídios para repensar o desafio da educação superior, especialmente o da pós-graduação na área da Administração, a partir da avaliação dos papéis dos atores sociais envolvidos no processo de ensino-aprendizagem e de suas expectativas em relação aos demais: o aluno-cliente, o professor-gerente-educador e a instituição de ensino-mercantil. Durante um ano realizou-se uma pesquisa qualitativa com alunos e professores de uma pós-graduação lato sensu em uma Instituição de Ensino Superior privada. Os dados foram tratados através de análise de conteúdo. Constatou-se que, por parte dos corpos docente e discente, há distorções e falta de clareza quanto aos papéis desempenhados por cada elemento, gerando conflitos de interesses e que os papéis socialmente estabelecidos estão profundamente influenciados pela relação comercial do negócio educação, por vezes chocando-se com objetivos pedagógicos da educação.

  9. A cathepsin F-like peptidase involved in barley grain protein mobilization, HvPap-1, is modulated by its own propeptide and by cystatins

    Science.gov (United States)

    Diaz, Isabel

    2012-01-01

    Among the C1A cysteine proteases, the plant cathepsin F-like group has been poorly studied. This paper describes the molecular and functional characterization of the HvPap-1 cathepsin F-like protein from barley. This peptidase is N-glycosylated and has to be processed to become active by its own propeptide being an important modulator of the peptidase activity. The expression pattern of its mRNA and protein suggest that it is involved in different proteolytic processes in the barley plant. HvPap-1 peptidase has been purified in Escherichia coli and the recombinant protein is able to degrade different substrates, including barley grain proteins (hordeins, albumins, and globulins) stored in the barley endosperm. It has been localized in protein bodies and vesicles of the embryo and it is induced in aleurones by gibberellin treatment. These three features support the implication of HvPap-1 in storage protein mobilization during grain germination. In addition, a complex regulation exerted by the barley cystatins, which are cysteine protease inhibitors, and by its own propeptide, is also described PMID:22791822

  10. Fanm ayisyen pap kase: respecting the right to health of Haitian women and girls.

    Science.gov (United States)

    Davis, Lisa; Bookey, Blaine

    2011-07-14

    Only in recent years has violence against women begun to receive international attention as both a public health and human rights concern. This article argues that the right to be free from sexual violence is a fundamental component of the right to health, and the need is particularly acute in post-disaster contexts. This article uses post-earthquake Haiti as a case study to illustrate conditions for women and girls who suffer daily threats of physical, emotional, economic, and social harm in ways that have no direct parallels for their male counterparts. In addition, this article discusses the reasons that the humanitarian response in Haiti has not effectively protected women and girls and has instead exacerbated structural inequalities, making women, girls, and their families even more vulnerable to human rights violations including interference in their right to health. The article argues that the failure to guarantee the right of women to be free from sexual violence - an essential component of the right to health - is due in large part to the exclusion of displaced women from meaningful participation in formal humanitarian interventions. Copyright © 2011 Davis and Bookey. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

  11. Continuous Flow Hygroscopicity-Resolved Relaxed Eddy Accumulation (Hy-Res REA) Method of Measuring Size-Resolved Sea-Salt Particle Fluxes

    Science.gov (United States)

    Meskhidze, N.; Royalty, T. M.; Phillips, B.; Dawson, K. W.; Petters, M. D.; Reed, R.; Weinstein, J.; Hook, D.; Wiener, R.

    2017-12-01

    The accurate representation of aerosols in climate models requires direct ambient measurement of the size- and composition-dependent particle production fluxes. Here we present the design, testing, and analysis of data collected through the first instrument capable of measuring hygroscopicity-based, size-resolved particle fluxes using a continuous-flow Hygroscopicity-Resolved Relaxed Eddy Accumulation (Hy-Res REA) technique. The different components of the instrument were extensively tested inside the US Environmental Protection Agency's Aerosol Test Facility for sea-salt and ammoniums sulfate particle fluxes. The new REA system design does not require particle accumulation, therefore avoids the diffusional wall losses associated with long residence times of particles inside the air collectors of the traditional REA devices. The Hy-Res REA system used in this study includes a 3-D sonic anemometer, two fast-response solenoid valves, two Condensation Particle Counters (CPCs), a Scanning Mobility Particle Sizer (SMPS), and a Hygroscopicity Tandem Differential Mobility Analyzer (HTDMA). A linear relationship was found between the sea-salt particle fluxes measured by eddy covariance and REA techniques, with comparable theoretical (0.34) and measured (0.39) proportionality constants. The sea-salt particle detection limit of the Hy-Res REA flux system is estimated to be 6x105 m-2s-1. For the conditions of ammonium sulfate and sea-salt particles of comparable source strength and location, the continuous-flow Hy-Res REA instrument was able to achieve better than 90% accuracy of measuring the sea-salt particle fluxes. In principle, the instrument can be applied to measure fluxes of particles of variable size and distinct hygroscopic properties (i.e., mineral dust, black carbon, etc.).

  12. Applying Sparse Machine Learning Methods to Twitter: Analysis of the 2012 Change in Pap Smear Guidelines. A Sequential Mixed-Methods Study.

    Science.gov (United States)

    Lyles, Courtney Rees; Godbehere, Andrew; Le, Gem; El Ghaoui, Laurent; Sarkar, Urmimala

    2016-06-10

    It is difficult to synthesize the vast amount of textual data available from social media websites. Capturing real-world discussions via social media could provide insights into individuals' opinions and the decision-making process. We conducted a sequential mixed methods study to determine the utility of sparse machine learning techniques in summarizing Twitter dialogues. We chose a narrowly defined topic for this approach: cervical cancer discussions over a 6-month time period surrounding a change in Pap smear screening guidelines. We applied statistical methodologies, known as sparse machine learning algorithms, to summarize Twitter messages about cervical cancer before and after the 2012 change in Pap smear screening guidelines by the US Preventive Services Task Force (USPSTF). All messages containing the search terms "cervical cancer," "Pap smear," and "Pap test" were analyzed during: (1) January 1-March 13, 2012, and (2) March 14-June 30, 2012. Topic modeling was used to discern the most common topics from each time period, and determine the singular value criterion for each topic. The results were then qualitatively coded from top 10 relevant topics to determine the efficiency of clustering method in grouping distinct ideas, and how the discussion differed before vs. after the change in guidelines . This machine learning method was effective in grouping the relevant discussion topics about cervical cancer during the respective time periods (~20% overall irrelevant content in both time periods). Qualitative analysis determined that a significant portion of the top discussion topics in the second time period directly reflected the USPSTF guideline change (eg, "New Screening Guidelines for Cervical Cancer"), and many topics in both time periods were addressing basic screening promotion and education (eg, "It is Cervical Cancer Awareness Month! Click the link to see where you can receive a free or low cost Pap test.") It was demonstrated that machine learning

  13. A historical review of promotion strategies for electricity from renewable energy sources in EU countries

    International Nuclear Information System (INIS)

    Haas, Reinhard; Panzer, Christian; Resch, Gustav; Ragwitz, Mario; Held, Anne; Reece, Gemma

    2011-01-01

    The core objective of this paper is to elaborate on historically implemented promotion strategies of renewable energy sources and the associated deployment within the European electricity market. Hence, at a first glance, the historic development of renewable energy sources in the electricity (RES-E) sector is addressed on Member State and on sectoral level as well as consequently discussed according to available RES-E potentials and costs. The specific focus of this paper, are promotion strategies for RES-E options as they are the key driver of an efficient and effective RES-E deployment. Therefore, the paper depicts the main types of different promotion schemes and their properties. Additionally, several cases studies of different European Member States show an in-depth analysis of the different RES-E promotion schemes. In this context, special emphasises are put on the question of effective and efficient promotion scheme designs of different RES-E technologies. Generally, conducted research led to the conclusion, that technology specific financial support measures of RES-E performed much more effective and efficient than others did. Hence, it is not all about the common question of feed-in tariffs vs. quota systems based on tradable green certificates, but more about the design criteria of implemented RES-E support schemes. (author)

  14. Unraveling the Raman Enhancement Mechanism on 1T'-Phase ReS2 Nanosheets.

    Science.gov (United States)

    Miao, Peng; Qin, Jing-Kai; Shen, Yunfeng; Su, Huimin; Dai, Junfeng; Song, Bo; Du, Yunchen; Sun, Mengtao; Zhang, Wei; Wang, Hsing-Lin; Xu, Cheng-Yan; Xu, Ping

    2018-04-01

    2D transition metal dichalcogenides materials are explored as potential surface-enhanced Raman spectroscopy substrates. Herein, a systematic study of the Raman enhancement mechanism on distorted 1T (1T') rhenium disulfide (ReS 2 ) nanosheets is demonstrated. Combined Raman and photoluminescence studies with the introduction of an Al 2 O 3 dielectric layer unambiguously reveal that Raman enhancement on ReS 2 materials is from a charge transfer process rather than from an energy transfer process, and Raman enhancement is inversely proportional while the photoluminescence quenching effect is proportional to the layer number (thickness) of ReS 2 nanosheets. On monolayer ReS 2 film, a strong resonance-enhanced Raman scattering effect dependent on the laser excitation energy is detected, and a detection limit as low as 10 -9 m can be reached from the studied dye molecules such as rhodamine 6G and methylene blue. Such a high enhancement factor achieved through enhanced charge interaction between target molecule and substrate suggests that with careful consideration of the layer-number-dependent feature and excitation-energy-related resonance effect, ReS 2 is a promising Raman enhancement platform for sensing applications. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. A study on the electronic and interfacial structures of monolayer ReS2-metal contacts.

    Science.gov (United States)

    Wang, Jin; Yang, Guofeng; Sun, Rui; Yan, Pengfei; Lu, Yanan; Xue, Junjun; Chen, Guoqing

    2017-10-11

    In this paper, we perform a systematic and rigorous study to evaluate the Ohmic nature of the top-contact formed by the monolayer ReS 2 (mReS 2 ) and metals (gold, silver, platinum, nickel, titanium, and scandium) by means of first-principles density functional theory calculations. We investigate the potential barrier, charge transfer and atomic orbital overlap at the mReS 2 -metal interface in consideration of van der Waals forces to understand how efficiently carriers could be injected from the metal contact to the mReS 2 channel. ReS 2 is physisorbed on Au and Ag, which leads to little perturbation of its electronic structures and forms a larger Schottky contact and a higher tunnel barrier at the interface. ReS 2 is chemisorbed on Ti and Sc, where the bonding strongly perturbs the electronic structures and is found to be purely Ohmic. The bonding of ReS 2 on Pt and Ni lies between these two extreme cases, demonstrating an intermediate behavior. These findings not only provide an insight into the mReS 2 -metal interfaces but may also prove to be instrumental in the future design of ReS 2 -based devices with good performance.

  16. Economic dispatch optimization for system integrating renewable energy sources

    Science.gov (United States)

    Jihane, Kartite; Mohamed, Cherkaoui

    2018-05-01

    Nowadays, the use of energy is growing especially in transportation and electricity industries. However this energy is based on conventional sources which pollute the environment. Multi-source system is seen as the best solution to sustainable development. This paper proposes the Economic Dispatch (ED) of hybrid renewable power system. The hybrid system is composed of ten thermal generators, photovoltaic (PV) generator and wind turbine generator. To show the importance of renewable energy sources (RES) in the energy mix we have ran the simulation for system integrated PV only and PV plus wind. The result shows that the system with renewable energy sources (RES) is more compromising than the system without RES in terms of fuel cost.

  17. The value of colposcopy, high risk HPV-DNA and histopathologic examination in the management of abnormal Pap smear results

    Directory of Open Access Journals (Sweden)

    Vugar Bayramov

    2011-12-01

    Full Text Available Objective: Pap smear test is a major screening test for early diagnosis and treatment of cervix cancer. The aim of our study was to assess the value of HPV-DNA, colposcopy and histopathologic examination in the management of patients with abnormal cervical cytology. Materials and methods: This prospective cohort study was conducted in Ankara University Cebeci Hospital gynecology outpatient clinic. The study compremised 86 patients with smear results of ASCUS, AGC, L-SIL and H-SIL. Age, gravity, parity, age at first coitus, smoking status, number of partners, high risk HPV-DNA status and pathologic colposcopy findings were investigated. Results: Mean age of the patients was 35 years and the most common abnormal smear result was ASCUS, with 55 patients (63%. There was no significant difference between the groups regarding demographic characteristics except age at first coitus and pathologic colposcopy findings. Among patients diagnosed as ASCUS 34.5% had been up-graded with histopathologic examination. Among patients diagnosed as L-SIL 73.6% had been down-graded with histopathologic examination. However, after the histopathologic exam of 9 H-SIL patients two (22.2% were diagnosed as CIN II, two (22.2% were diagnosed as CIN III and one (11.1% was diagnosed as cervical cancer. In the groups of ASCUS, L-SIL and H-SIL the presence of high risk HPV-DNA were 11%, 5% and 33%, respectively. Conclusion: If we are sure that the patient will attend the follow-up visits, then fort he ones with ASCUS and L-SIL a repeat smear test would be the appropriate. However, in the management of patients with H-SIL colposcopic biopsy would be the best approach.

  18. Das Ende der Literatur als sekundäres Kommunikationsmittel?

    Directory of Open Access Journals (Sweden)

    Hikmet TAN

    2013-12-01

    Full Text Available The End of Literature as an Indirect Medium – With the digital revolution incommunication technology, communication has accelerated and communication means, have becomevirtual and digital processes. As a secondary communication mean, literature in general and novel in specific, have been affected quite much and they are still being affected. In this study, taking the role of digital technology in culture process as a base, the condition of novel as a secondary culture source is taken into consideration with a critical point of view.Key words: Audiovisuality, aesthetics, novel.

  19. Room temperature synthesis of ReS2 through aqueous perrhenate sulfidation

    Science.gov (United States)

    Borowiec, Joanna; Gillin, William P.; Willis, Maureen A. C.; Boi, Filippo S.; He, Y.; Wen, J. Q.; Wang, S. L.; Schulz, Leander

    2018-02-01

    In this study, a direct sulfidation reaction of ammonium perrhenate (NH4ReO4) leading to a synthesis of rhenium disulfide (ReS2) is demonstrated. These findings reveal the first example of a simplistic bottom-up approach to the chemical synthesis of crystalline ReS2. The reaction presented here takes place at room temperature, in an ambient and solvent-free environment and without the necessity of a catalyst. The atomic composition and structure of the as-synthesized product were characterized using several analysis techniques including energy dispersive x-ray spectroscopy, x-ray photoelectron spectroscopy, x-ray diffraction, transmission electron microscopy, Raman spectroscopy, thermogravimetric analysis and differential scanning calorimetry. The results indicated the formation of a lower symmetry (1Tʹ) ReS2 with a low degree of layer stacking.

  20. Hierarchical architecture of ReS_2/rGO composites with enhanced electrochemical properties for lithium-ion batteries

    International Nuclear Information System (INIS)

    Qi, Fei; Chen, Yuanfu; Zheng, Binjie; He, Jiarui; Li, Qian; Wang, Xinqiang; Lin, Jie; Zhou, Jinhao; Yu, Bo; Li, Pingjian; Zhang, Wanli

    2017-01-01

    Highlights: • The ReS_2/rGO composites have been synthesized by a facile one-pot method. • The ReS_2/rGO composites exhibit hierarchical architecture. • The ReS_2/rGO composites deliver better electrochemical performances than ReS_2. • The enhanced performance is due to porous and conductive structure of ReS_2/rGO. - Abstract: Rhenium disulfide (ReS_2), a two-dimensional (2D) semiconductor, has attracted more and more attention due to its unique anisotropic electronic, optical, mechanical properties. However, the facile synthesis and electrochemical property of ReS_2 and its composite are still necessary to be researched. In this study, for the first time, the ReS_2/reduced graphene oxide (rGO) composites have been synthesized through a facile and one-pot hydrothermal method. The ReS_2/rGO composites exhibit a hierarchical, interconnected, and porous architecture constructed by nanosheets. As anode for lithium-ion batteries, the as-synthesized ReS_2/rGO composites deliver a large initial capacity of 918 mAh g"−"1 at 0.2 C. In addition, the ReS_2/rGO composites exhibit much better electrochemical cycling stability and rate capability than that of bare ReS_2. The significant enhancement in electrochemical property can be attributed to its unique architecture constructed by nanosheets and porous structure, which can allow for easy electrolyte infiltration, efficient electron transfer, and ionic diffusion. Furthermore, the graphene with high electronic conductivity can provide good conductive passageways. The facile synthesis approach can be extended to prepare other 2D transition metal dichalcogenides semiconductors for energy storage and catalytic application.

  1. Valorisation par voie hydrométallurgique de Matières Premières Secondaires Valorization of Secondary Raw Materials by hydrometallurgical way

    Directory of Open Access Journals (Sweden)

    Meux Eric

    2013-11-01

    Full Text Available Cet exposé s'intéressera à la récupération par voie hydrométallurgique de métaux contenus dans les Matières Premières Secondaires. Dans un premier temps seront abordées des généralités sur les Métaux Critiques, leur taux de recyclage et les gisements identifiés. Deux exemples de traitement seront ensuite développés : le traitement de catalyseurs d'hydrotraitement et le traitement de poudres métallifères issues de broyats d'accumulateurs par couplage électrolixiviation/électrodéposition. This talk will focus on the hydrometallurgical recovery of metals contained in secondary raw materials. At first, generalities about critical metals, their recycling rate and their identified supply will be addressed. Two examples of hydrometallurgical treatment will be then developed: the treatment of spent hydrotreating catalysts and the treatment of electrodes powders coming from grinding of spent batteries by coupling electroleaching/electrodeposition.

  2. Rationale and design of the iPap trial: a randomized controlled trial of home-based HPV self-sampling for improving participation in cervical screening by never- and under-screened women in Australia

    International Nuclear Information System (INIS)

    Sultana, Farhana; Gertig, Dorota M; English, Dallas R; Simpson, Julie A; Brotherton, Julia ML; Drennan, Kelly; Mullins, Robyn; Heley, Stella; Wrede, C David; Saville, Marion

    2014-01-01

    Organized screening based on Pap tests has substantially reduced deaths from cervical cancer in many countries, including Australia. However, the impact of the program depends upon the degree to which women participate. A new method of screening, testing for human papillomavirus (HPV) DNA to detect the virus that causes cervical cancer, has recently become available. Because women can collect their own samples for this test at home, it has the potential to overcome some of the barriers to Pap tests. The iPap trial will evaluate whether mailing an HPV self-sampling kit increases participation by never- and under-screened women within a cervical screening program. The iPap trial is a parallel randomized controlled, open label, trial. Participants will be Victorian women age 30–69 years, for whom there is either no record on the Victorian Cervical Cytology Registry (VCCR) of a Pap test (never-screened) or the last recorded Pap test was between five to fifteen years ago (under-screened). Enrolment information from the Victorian Electoral Commission will be linked to the VCCR to determine the never-screened women. Variables that will be used for record linkage include full name, address and date of birth. Never- and under-screened women will be randomly allocated to either receive an invitation letter with an HPV self-sampling kit or a reminder letter to attend for a Pap test, which is standard practice for women overdue for a test in Victoria. All resources have been focus group tested. The primary outcome will be the proportion of women who participate, by returning an HPV self-sampling kit for women in the self-sampling arm, and notification of a Pap test result to the Registry for women in the Pap test arm at 3 and 6 months after mailout. The most important secondary outcome is the proportion of test-positive women who undergo further investigations at 6 and 12 months after mailout of results. The iPap trial will provide strong evidence about whether HPV self

  3. In Search of the ‘New Informal Legitimacy’ of Médecins Sans Frontières

    Science.gov (United States)

    Calain, Philippe

    2012-01-01

    For medical humanitarian organizations, making their sources of legitimacy explicit is a useful exercise, in response to: misperceptions, concerns over the ‘humanitarian space’, controversies about specific humanitarian actions, challenges about resources allocation and moral suffering among humanitarian workers. This is also a difficult exercise, where normative criteria such as international law or humanitarian principles are often misrepresented as primary sources of legitimacy. This essay first argues for a morally principled definition of humanitarian medicine, based on the selfless intention of individual humanitarian actors. Taking Médecins Sans Frontières (MSF) as a case in point, a common source of moral legitimacy for medical humanitarian organizations is their cosmopolitan appeal to distributive justice and collective responsibility. More informally, their legitimacy is grounded in the rightfulness of specific actions and choices. This implies a constant commitment to publicity and accountability. Legitimacy is also generated by tangible support from the public to individual organizations, by commitments to professional integrity, and by academic alliances to support evidence-based practice and operational research. PMID:22442647

  4. Energy and climate hand-in-hand: Financing RES-E support with carbon revenues

    International Nuclear Information System (INIS)

    Verde, Stefano F.; Pazienza, Maria Grazia

    2016-01-01

    In Italy, the cost of support for renewable electricity (RES-E) is largely recovered through the “A3 surcharge”, which weighs heavily on electricity bills. Using household survey data, we show the A3 surcharge is markedly regressive. Carbon taxation in the non-ETS sector is envisaged as a means to reduce CO_2 emissions cost-effectively and generate revenue to lower the A3 surcharge. A non-ETS carbon tax would be less regressive than the A3 surcharge and its cost would be more evenly distributed across households. We calculate the revenue of a €20/tCO_2 non-ETS carbon tax would have allowed a cut in the A3 surcharge of about 68% in 2011, and 39% in 2012. The impact of the carbon tax plus the reduced A3 surcharge would have been less regressive, but the cost higher for most households. The restrictions imposed in the simulations mean the results are only appropriate to render first-round effects of the reform. Policy relevance: In the vast majority of the EU Member States, the cost of RES-E support is largely paid by electricity consumers, most often through specific surcharges. Rising electricity prices are a common concern given the implications for competitiveness and equity. The Member States facing this issue could conveniently address it through environmental tax reforms consistent with the Climate and Energy Package. Replacing RES-E surcharges with carbon taxes in the non-ETS sector would permit cost-effective reduction of CO_2 emissions while allocating the cost of RES-E support more equitably. The difference in regressivity would stem from the different consumption patterns of home fuels (including electricity) and motor fuels across income distribution. A cross-country comparison of energy household budget shares proves the structural nature of this difference between home fuels and motor fuels. Moreover, the notion that electricity consumers should pay for RES-E support is questioned on the grounds that electricity is a basic necessity good and RES

  5. Pap and HPV Testing

    Science.gov (United States)

    ... 5):368-383. [PubMed Abstract] Wheeler CM. Natural history of human papillomavirus infections, cytologic and histologic abnormalities, and cancer. Obstetrics and Gynecology Clinics of North America 2008; 35( ...

  6. [Verification of doubtful PAP smear results of women included in the screening program in the Podlaskie province].

    Science.gov (United States)

    Błońska, Ewa; Knapp, Piotr Andrzej

    2013-08-01

    Verification of uncertain PAP-smear results in a group of women covered by the cervical screening program in the Podlaski province. The main aim of the study was to identify CIN (Cervical Intraepithelial Neoplasia) lesions present, with varying degrees of severity in women with cytological diagnosis of ASCUS (atypical squamous cells of undetermined significance), LSIL (low grade squamous intraepithelial lesion), and ASC-H (atypical squamous cells - cannot exclude high grade squamous intraepithelial lesion). The study evaluated 101 cervical smears taken from the vaginal part of the cervix in a group of screened women in the Podlaski province. Cytological evaluation was performed according the Bethesda System. We analyzed abnormal smears selected from a total of 7296 cytological examinations performed during 2012 at the University Center for Pathomorphological and Genetic - Molecular Diagnosis, Medical University in Białystok. The cytological results which were of interest to us included 19 cases with ASCUS, 59 with LSIL, and 23 with ASC-H, as well as with morphological features of the presence of Human Papilloma Virus (HPV). Staining was performed using CINtecPLUS test according to the manufacturer's instructions. CINtecPLUS is a immunocytochemical test based on specially designed monoclonal antibodies (E6H4TM) that let us identify protein p16ink4a within the cervical smear Additionally the diagnostic kit was provided with antibodies for diagnosing the presence of Ki-67 protein, a known marker of cell proliferation. The result was considered positive when staining of the nucleus and the cytoplasm appeared in red and brown, respectively. All abnormal results were eventually verified by histological examination of the tissue taken from cervical lesions by diagnostic-therapeutic procedure following colposcopic evaluation of cervical lesion topography In the group of cytological smears with ASCUS, the diagnosis was positive in 5 cases (26.3%), negative in 14 (73

  7. Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP)

    Energy Technology Data Exchange (ETDEWEB)

    Dombrovski, Luidmila; Dong, Aiping; Bochkarev, Alexey; Plotnikov, Alexander N. (Toronto)

    2008-09-17

    Cytosolic sulfotransferases (SULTs), often referred as Phase II enzymes of chemical defense, are a superfamily of enzymes that catalyze the transfer of a sulfonate group from 3{prime}-phosphoadenosine 5{prime}-phosphosulfate (PAPS) to an acceptor group of substrates. This reaction modulates the activities of a large array of small endogenous and foreign chemicals including drugs, toxic compounds, steroid hormones, and neurotransmitters. In some cases, however, SULTs activate certain food and environmental compounds to mutagenenic and carcinogenic metabolites. Twelve human SULTs have been identified, which are partitioned into three families: SULT1, SULT2 and SULT4. The SULT1 family is further divided in four subfamilies, A, B, C, and E, and comprises eight members (1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 1C3, and 1E1). Despite sequence and structural similarity among the SULTs, the family and subfamily members appear to have different biological function. SULT1 family shows substrate-binding specificity for simple phenols, estradiol, and thyroid hormones, as well as environmental xenobiotics and drugs. Human SULT1B1 is expressed in liver, colon, small intestine, and blood leukocytes, and shows substrate-binding specificity to thyroid hormones and benzylic alcohols. Human SULT1C1 is expressed in the adult stomach, kidney, and thyroid, as well as in fetal kidney and liver. SULT1C1 catalyzes the sulfonation of p-nitrophenol and N-hydroxy-2-acetylaminofluorene in vitro. However, the in vivo function of the enzyme remains unknown. We intend to solve the structures for all of the SULTs for which structural information is not yet available, and compare the structural and functional features of the entire SULT superfamily. Here we report the structures of two members of SULT1 family, SULT1B1 and SULT1C1, both in complex with the product of the PAPS cofactor, adenosine-3{prime}-5{prime}-diphosphate (PAP).

  8. STUDY OF CERVICAL PAP SMEAR STUDY AND ITS UTILITY IN CANCER SCREENING- AN EXPERIENCE IN A TERTIARY CARE HOSPITAL OF TRIPURA, NORTH EASTERN STATE OF INDIA

    Directory of Open Access Journals (Sweden)

    Sutanuka Khasnabish

    2017-06-01

    Full Text Available BACKGROUND Cancer of cervix is a global health problem and is a leading cause of morbidity and mortality of women in India. It is one of the most preventable and curable of all cancers. Simple, noninvasive screening procedures like Papanicolaou smears can help in detection and quick and effective timely treatment. The objective of the study is to assess the role of Pap smear in detecting premalignant, malignant and nonneoplastic lesions of cervix in our institute. MATERIALS AND METHODS This is a one year prospective and four year retrospective study of 1,349 women in age group of 20-80 years carried over a period of 5 years from January 2012-December 2016 in the cytology wing of Department of Pathology, Tripura Medical College. Patients clinically presenting with dyspareunia, postcoital bleeding, vaginal bleeding, frothy vaginal discharge with itching and pain in hypogastrium were included in the study. Samples were collected under direct vision of Cusco’s speculum and transferred to glass slides, fixed and stained by Papanicolaou stain and were examined and reported. Reporting was done as per Bethesda system. RESULTS A total of 1,349 number of cases were screened, out of which 639 number of patients had abnormal Pap smears and 13.63% had unsatisfactory or inadequate samples. LSIL was the most common premalignant lesion with 113 (8.37% number of cases, SCC in 39 (5.2% number of cases, ASCUS in 15 (1.11% and adenocarcinoma in 2 (0.14% number of cases. CONCLUSION It was found that premalignant and malignant lesion in cervix is not uncommon in our setup and Pap smear appears to be an elementary, economical, safe and yet highly sensitive screening test for early detection of various cervical lesions.

  9. Factors Associated with Pap Smear Implementation among Women Referring to Healthcare Centers in Fasa, Iran: An Application of Theory of Planned Behavior

    Directory of Open Access Journals (Sweden)

    Zahra Moradi

    2017-06-01

    Full Text Available Background and Objective: Cervical cancer is the second most common cancer among the females. This cancer is considered as a preventable disease due to having a long period before the invasion, availability of appropriate screening program, and effective treatment of primary lesions. The aim of this study was to determine the factors related to per forming regular Pap smear test based on the Theory of Planned Behavior (TPB among the females living in Fasa, Iran. Materials and Methods: This descriptive-analytic cross-sectional study was conducted on 700 married women in Fasa city in 2016. The study population was selected from the females referring to the healthcare centers of Fasa using simple random sampling technique. The data were collected by means of a three-part questionnaire, including demographic data, knowledge, and TPB constructs. Data analysis was performed using Pearson correlation coefficient test and logistic regression in SPSS, version 22. Results: According to the results, 45.7% of the patients had a history of undergoing a Pap smear test, and 20.7% of them performed this test regularly. The results indicated that knowledge, attitude, subjective norms, and perceived behavioral control were the predictors of intention and behavior of Pap smear test among the women (P<0.05. These components accounted for 57.4% and 31.6% of the intention and behavior variance, respectively. Conclusion: As the findings of this study indicated, it is possible to increase the level of screening behaviors among the women by improving their awareness, attitude, subjective norms, and perceived behavioral control. This measure in turn plays a significant role in the prevention and control of cervical cancer.

  10. Psychometric performance and responsiveness of the functional outcomes of sleep questionnaire and sleep apnea quality of life instrument in a randomized trial: the HomePAP study.

    Science.gov (United States)

    Billings, Martha E; Rosen, Carol L; Auckley, Dennis; Benca, Ruth; Foldvary-Schaefer, Nancy; Iber, Conrad; Zee, Phyllis C; Redline, Susan; Kapur, Vishesh K

    2014-12-01

    Measures of health-related quality of life (HRQL) specific for sleep disorders have had limited psychometric evaluation in the context of randomized controlled trials (RCTs). We investigated the psychometric properties of the Functional Outcomes of Sleep Questionnaire (FOSQ) and Sleep Apnea Quality of Life Instrument (SAQLI). We evaluated the FOSQ and SAQLI construct and criterion validity, determined a minimally important difference, and assessed for associations of responsiveness to baseline subject characteristics and continuous positive airway pressure (CPAP) adherence in a RCT population. Secondary analysis of data collected in a multisite RCT of home versus laboratory-based diagnosis and treatment of obstructive sleep apnea (HomePAP trial). Individuals enrolled in the HomePAP trial (n = 335). N/A. The FOSQ and SAQLI subscores demonstrated high reliability and criterion validity, correlating with Medical Outcomes Study 36-Item Short Form Survey domains. Correlations were weaker with the Epworth Sleepiness Scale (ESS). Both the FOSQ and SAQLI scores improved after 3 mo with CPAP therapy. Averaging 4 h or more of CPAP use was associated with an increase in the FOSQ beyond the minimally important difference. Baseline depressive symptoms and sleepiness predicted FOSQ and SAQLI responsiveness; demographic, objective obstructive sleep apnea (OSA) severity and sleep habits were not predictive in linear regression. The FOSQ and SAQLI are responsive to CPAP intervention, with the FOSQ being more sensitive to differences in CPAP adherence than the SAQLI. These instruments provide unique information about health outcomes beyond that provided by changes in physiological measures of OSA severity (apnea-hypopnea index). Portable Monitoring for Diagnosis and Management of Sleep Apnea (HomePAP) URL: http://clinicaltrials.gov/show/NCT00642486. NIH clinical trials registry number: NCT00642486. © 2014 Associated Professional Sleep Societies, LLC.

  11. Modèles de gestion des ressources forestières du massif ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Expérimentation Participative et Adaptative de Modèles de Gestion des Ressources Forestières dans la Chaine Montagneuse de l'Atlas (Algérie, Maroc, Tunisie) : rapport final (17 mars 2009 au 18 septembre 2012). Download PDF. Reports. Unité de transformation de cire d'abeille (Commune de M'Sara). Download PDF ...

  12. Res, aliquid and nihil in Suárez and modern philosophy

    Directory of Open Access Journals (Sweden)

    Leopoldo Prieto López

    2013-07-01

    Full Text Available the main relevant philosophical aspect in Suárez’s interpretation of the transcendentals is his doctrine of the notions res and aliquid. therefore, after analyzing the nature and the number of the transcendentals, as well as the relationship between them and the first principles, the article goes into a detailed historical analysis of the notions res and aliquid. With precedents in Avicenna and Duns Scotus, the ens is understood according to Suarez, negatively, as it is not nothing and, in such sense, it is something (aliquid and, positively, as it has got a quidditas and, therefore, it is res. the question of nothing (nihil is thus introduced into modern metaphysics. What’s more, the said interpretation is one of the fundamental conditions of the transformation of metaphysics in modern ontology. thus, in the post- Cartesian context of Schulmetaphysik, and its aliquitas (as non-nihil and its quiditative character (as res being presumed, the ens will be understood as an intelligible. through that, a Copernican revolution commenced that anticipated Kant himself.

  13. Res Publica murrab läbi / Urmo Kübar

    Index Scriptorium Estoniae

    Kübar, Urmo, 1978-

    2004-01-01

    Ilmunud ka: Võta Võim : na russkom jazõke, 28. apr. 2004, lk. 1. 18. aprillil 2004 Tallinnas toimunud Res Publica valimiskonverentsist, kus kinnitati programm ja kandidaadid Euroopa Parlamendi valimisteks. Esinesid Urmas Reinsalu ja Juhan Parts. Vt. samas: Kust tuli 'Murrame läbi'?

  14. Res Publica alustas Tallinnas koostööd Keskerakonnaga / Siim Männik

    Index Scriptorium Estoniae

    Männik, Siim

    2005-01-01

    Ilmunud ka: Vabariik (venek.) 18. apr. lk. 2. Koalitsioonivahetusest Tallinnas. Linnavolikogu Res Publica fraktsiooni esimehe Andres Korgi, linnapea Tõnis Paltsi nõuniku Jaano Martin Otsa kommentaare. Tallinna linnapea hinnangul on sügisel koalitsiooni asudes seatud eesmärgid praeguseks peaaegu saavutatud

  15. Médecins Sans Frontières moves to protect refugee healthcare

    African Journals Online (AJOL)

    As Médecins Sans Frontières (MSF) spurned all European Union (EU) fund ing for its projects worldwide after a series of cynical EUcountry moves to choke inward refugee flow, South African. (SA) activists in Johannesburg this June protes ted the proposed stiffening of local refugee laws. The People's Coalition Against ...

  16. Dynamique de fréquentation des grands mammifères dans une ...

    African Journals Online (AJOL)

    SARAH

    31 juil. 2016 ... 2016 Dynamique de fréquentation des grands mammifères dans une clairière ... 2Ecole Régionale Post-Universitaire d'Aménagement et de gestion Intégrés des Forêts et ..... épidémiologique et contrôle des stomoxes à la.

  17. Res-Parity: Parity Violation in Inelastic scattering at Low Q2

    International Nuclear Information System (INIS)

    Paul Reimer; Peter Bosted; John Arrington; Hamlet Mkrtchyan; Xiaochao Zheng

    2006-01-01

    Parity violating electron scattering has become a well established tool which has been used, for example, to probe the Standard Model and the strange-quark contribution to the nucleon. While much of this work has focused on elastic scattering, the RES-Parity experiment, which has been proposed to take place at Jefferson Laboratory, would focus on inelastic scattering in the low-Q 2 , low-W domain. RES-Parity would search for evidence of quark-hadron duality and resonance structure with parity violation in the resonance region. In terms of parity violation, this region is essentially unexplored, but the interpretation of other high-precision electron scattering experiments will rely on a reasonable understanding of scattering at lower energy and low-W through the effects of radiative corrections. RES-Parity would also study nuclear effects with the weak current. Because of the intrinsic broad band energy spectrum of neutrino beams, neutrino experiments are necessarily dependent on an untested, implicit assumption that these effects are identical to electromagnetic nuclear effects. RES-Parity is a relatively straight forward experiment. With a large expected asymmetry (∼ 0.5 x 10 -4 ) these studies may be completed with in a relatively brief period

  18. Taani ristisõjad Läänemere ääres / Linda Kaljundi

    Index Scriptorium Estoniae

    Kaljundi, Linda

    2007-01-01

    Raamatututvustus: Taani ristisõjad - sõda ja misjon Läänemere ääres / John H. Lind, Carsten Selch Jensen, Kurt Villads Jensen, Ane L. Bysted ; tõlkijad Ivar Rüütli ja Kalle Kroon ; teaduslik toimetaja ja järelsõna: Linda Kaljundi. Tallinn : Argo, 2007

  19. Proposta de um desenho da cadeia reversa para resíduos eletroeletrônicos

    Directory of Open Access Journals (Sweden)

    Reinaldo Alves de Sá Ferreira Júnior

    2016-12-01

    Full Text Available Com o crescimento da demanda dos equipamentos eletroeletrônicos e de sua rápida obsolescência, gera-se grande volume de resíduos, os quais possuem metais pesados altamente tóxicos, como o mercúrio, cobre, chumbo, arsênio, entre outros. A implantação da Logística Reversa (LR tem sido uma forma de gestão de grande sucesso, tanto no contexto internacional como nacional, e aliada a Politica Nacional de Resíduos Sólidos (PNRS tornou-se uma forma mais eficaz para o gerenciamento desses resíduos. Este artigo teve como objetivo, a partir da revisão na literatura referente à LR, PNRS e REEE apresentar atores, atribuições e processos associados, propondo, desta forma, uma estrutura geral para a cadeia de suprimentos reversa de pós-consumo associada aos REEE. A principal contribuição do artigo é proposição de um desenho da cadeia reversa para resíduos Eletroeletrônicos.

  20. Res Publica nõuab rea võimulubaduste täitmist / Rasmus Kagge

    Index Scriptorium Estoniae

    Kagge, Rasmus, 1977-

    2005-01-01

    Res Publica lubas koalitsioonipartneritele mitte minna koalitsioonileppe kallale, kui nad toetavad toppama jäänud lubaduste täitmist - haridusreformi, presidendi otsevalimiste seadustamist, riigikontrollile ka omavalitsuste kontrollimiseks õiguse andmist ja lapsevanema tulumaksuvaba miinimumi kahekordistamist alates pere teisest lapsest. Lisa: Võimuliitlaste soovid

  1. Problematika operací s cennými papíry a finančními deriváty

    OpenAIRE

    Tejnský, Radko

    2010-01-01

    1 Resume Název: Problematika operací s cennými papíry a finančními deriváty Title: The issues of operations with securities and financial derivatives The aim of this thesis is to discuss selected issues of operations with securities (such as stocks, bonds, promissory notes, etc.) and financial derivatives. A financial derivative (or derivative security) is a financial instrument whose value depends on the values of other, more basic underlying variables. Commonly issued and frequently traded ...

  2. Psychosocial burden differences between women of reproductive age and menopausal age due to abnormal Pap smear: A pilot study of the East Coast of Malaysia

    Directory of Open Access Journals (Sweden)

    Shabbir Ahmad Sheikh

    2016-01-01

    Conclusion: Psychosocial burden due to abnormal Pap smear results in terms of mental stress, overwhelming beliefs, and feelings of guilt and worry of HPV infection and possibility of cervical cancer were noted more in reproductive age groups as compared to the menopausal age group. Health-care providers should be aware of these psychosocial effects whereby they can refer such patients to a gynecologic oncologist for proper counseling at the proper time so that the negative impact due to this psychosocial burden can be prevented.

  3. Res Publica soovib riigikogulaste kuluhüvitiste korra muutmist / Siim-Valmar Kiisler ; interv. Kalle Muuli

    Index Scriptorium Estoniae

    Kiisler, Siim, 1965-

    2003-01-01

    Res Publica saadikud teevad Riigikogu juhatusele ettepaneku muuta kuluhüvitiste korda, teatas intervjuus Res Publica saadikurühma esimees Siim-Valmar Kiisler. Kommenteerivad: Jaanus Männik, Toomas Varek. Vt. samas: Riigikogu liikmete vastuseid küsimustele tööga seotud kulude kohta: Robert Lepikson, Reet Roos, Janno Reiljan

  4. Analüütikud ennustavad Res Publicale mõõnast pääsu / Rasmus Kagge

    Index Scriptorium Estoniae

    Kagge, Rasmus, 1977-

    2005-01-01

    Poliitikavaatlejate hinnangul ületab Res Publica mõõna ja saab järgmistel parlamendivalimistel kuni 12 kohta, kui nad loobuvad "uue poliitika" stiilis loosungitest ja kõrkusest. Lisa: Mõõna põhjusi. Vt. samas: Taavi Veskimägi lubas lõpetada Res Publica peataoleku

  5. The impact of rhetoric and education on the "Res Gestae" of Ammianus Marcellinus

    Science.gov (United States)

    Alvarez, Pablo

    The aim of this thesis is to explore and underline the impact of education and rhetoric on the Res Gestae of Ammianus Marcellinus. I will examine the concept of education in two different aspects. First, I will determine the role of education in regards to Ammianus' early life by describing the cultural climate in the East in the fourth century (Introduction and chapter 1). In this analysis, I will argue that the historian's familiarity with Latin suggests an early acquaintance with the language, indicating that he should not be invariably associated with earlier Greek historians. Second, I will look at how the content of the curriculum is reflected in the RG, explaining how literary sources shaped the composition of the historian's digressions on geography (Chapter 3) and astronomy (Chapter 4). In the past, scholars have examined Ammianus' cultural digressions as an example of the tension between things seen and things read. In my argumentation, I will concentrate on explaining the reasons why Ammianus often tended to rely on literary works rather than observation. I will show that the explanation greatly lies in the content of the curriculum. Concerning the role of rhetoric, I will examine how rhetorical training is articulated in the RG. In Chapter 2, I will show that Ammianus' selection of historical material can be explained in light of the ancient theory of styles. In this context, I will study the role of a rhetorical device designed to raise the emotions of readers by bringing the scene before their eyes: enargeia. In Chapters 3 and 4, I will demonstrate that the cultural digressions in the RG are mostly the product of cultural stereotypes and literary influences. In Chapter 5, I will show the impact of rhetorical treatises on some passages of the RG, arguing that the traditional classification of oratory into deliberative, epideictic and judicial is echoed in both the speeches and the historical narrative. To conclude: the main purpose of my dissertation

  6. Identifying barriers in the diffusion of renewable energy sources

    International Nuclear Information System (INIS)

    Eleftheriadis, Iordanis M.; Anagnostopoulou, Evgenia G.

    2015-01-01

    Rapid diffusion of renewable energy sources (RES) in the electricity power sector is crucial if the EU wants to fulfill its 2050 CO 2 reduction commitments. For this reason, identifying and alleviating all barriers that hinder the development of RES is necessary to the successful deployment of these technologies. This paper discusses the main barriers in the diffusion of wind and photovoltaic (PV) solar power in the Greek electricity sector by drawing on the literature of technological innovation systems and system functions. Furthermore, we provide an explanation of the different diffusion rates between the two technologies. Inadequate financial resources, low grid capacity, delays in the issuance of building permits, opposition from local communities to the construction of wind farms and the lack of a stable institutional framework are among the most important barriers that inhibit the diffusion of the wind and PV solar power. The nature of the barriers identified in this study calls for policy intervention. - Highlights: • Firms in the Greek wind and solar power sectors assess RES barriers. • Lack of financial resources is the most important RES barrier. • Lack of a stable institutional framework negatively affects RES deployment. • The support of the public sector is crucial to the diffusion of RES. •Wind power faces strong legitimization barriers

  7. Copépodes, Cladocères et Rotifères du lac Sidi M'hamed Benali (Algérie Nord-Occidentale

    Directory of Open Access Journals (Sweden)

    Mohamed Ali Bouzidi

    2010-03-01

    Full Text Available En 2008, 33 espèces de Cladocères, Copépodes et Rotifères ont été observées dans le lac Sidi M'hamed Benali (contre 12 seulement en 1992.Les Copépodes dominent en mars, avril, juillet, août et septembre, avec respectivement des dominances (Do égales à : 56,6 %, 55,0 %, 55,0 %, 46,4 % et 90,0 %. Les Cladocères dominent en février (Do = 37,2 %, mai (Do = 47,4 % et décembre (Do = 48,6 %. Les Rotifères sont extrêmement abondants et présentent une large dominance en janvier (Do = 95,3 %. La population zooplanctonique est très faible en juillet et en août. Au cours de l'année le peuplement varie en fonction de la température, des conditions hydrologiques, de l'abondance de la nourriture et de la prédation par les poissons.In 2008, 33 species of Cladocers, Copepods and Rotifers have been observed in Sidi M’hamed Benali Lake (against only 12 species in 1992. The Copepods dominate in March, April, July, August and September, respectively with dominance (Do equal to 56.6 %, 55.0 %, 55.0 %, 46.4 % and 90.0 %. Cladocers dominated in February (Do = 37.2 %, May (Do = 47.4 % and December (Do = 48.6 %. The rotifers are extremely abundant and have a wide dominance in January (Do = 95.3%. The zooplankton population is very low in July and August. During the year, the population varies with temperature, water conditions, abundance of food and predation by fishes.

  8. Large scale integration of intermittent renewable energy sources in the Greek power sector

    International Nuclear Information System (INIS)

    Voumvoulakis, Emmanouil; Asimakopoulou, Georgia; Danchev, Svetoslav; Maniatis, George; Tsakanikas, Aggelos

    2012-01-01

    As a member of the European Union, Greece has committed to achieve ambitious targets for the penetration of renewable energy sources (RES) in gross electricity consumption by 2020. Large scale integration of RES requires a suitable mixture of compatible generation units, in order to deal with the intermittency of wind velocity and solar irradiation. The scope of this paper is to examine the impact of large scale integration of intermittent energy sources, required to meet the 2020 RES target, on the generation expansion plan, the fuel mix and the spinning reserve requirements of the Greek electricity system. We perform hourly simulation of the intermittent RES generation to estimate residual load curves on a monthly basis, which are then inputted in a WASP-IV model of the Greek power system. We find that the decarbonisation effort, with the rapid entry of RES and the abolishment of the grandfathering of CO 2 allowances, will radically transform the Greek electricity sector over the next 10 years, which has wide-reaching policy implications. - Highlights: ► Greece needs 8.8 to 9.3 GW additional RES installations by 2020. ► RES capacity credit varies between 12.2% and 15.3%, depending on interconnections. ► Without institutional changes, the reserve requirements will be more than double. ► New CCGT installed capacity will probably exceed the cost-efficient level. ► Competitive pressures should be introduced in segments other than day-ahead market.

  9. Cloning, purification, crystallization and preliminary X-ray diffraction studies of Escherichia coli PapD-like protein (EcpD)

    International Nuclear Information System (INIS)

    Pandey, Nishant Kumar; Pal, Ravi Kant; Kashyap, Maruthi; Bhavesh, Neel Sarovar

    2012-01-01

    The Escherichia coli PapD-like protein (EcpD), from uropathogenic Escherichia coli (UPEC), which is a periplasmic chaperon of Yad fimbriae was cloned, overexpressed, purified and crystallized. The crystals obtained diffracted X-rays to 1.67 Å resolution and belonged to space group C222 1 . Many Gram-negative bacteria are characterized by hair-like proteinaceous appendages on their surface known as fimbriae. In uropathogenic strains of Escherichia coli, fimbriae mediate attachment by binding to receptors on the host cell, often contributing to virulence and disease. E. coli PapD-like protein (EcpD) is a periplasmic chaperone that plays an important role in the proper folding and guiding of Yad fimbrial proteins to the outer membrane usher protein in a process known as pilus biogenesis. EcpD is essential for pilus biogenesis in uropathogenic E. coli and plays an important role in virulence. In the present study, EcpD was cloned, overexpressed, purified and crystallized by the hanging-drop vapour-diffusion method. The crystals diffracted to 1.67 Å resolution and belonged to the orthorhombic space group C222 1 , with unit-cell parameters a = 100.3, b = 127.6, c = 45.9 Å. There was a single molecule in the asymmetric unit and the corresponding Matthews coefficient was calculated to be 3.02 Å 3 Da −1 , with 59% solvent content. Initial phases were determined by molecular replacement

  10. An Evaluation Study of Enzyme-Linked Immunosorbent Assay (ELISA) Using Recombinant Protein Pap31 for Detection of Antibody against Bartonella bacilliformis Infection among the Peruvian Population

    Science.gov (United States)

    Angkasekwinai, Nasikarn; Atkins, Erin H.; Romero, Sofia; Grieco, John; Chao, Chien Chung; Ching, Wei Mei

    2014-01-01

    Reliable laboratory testing is of great importance to detect Bartonella bacilliformis infection. We evaluated the sensitivity and specificity of the enzyme-linked immunosorbent assay (ELISA) using recombinant protein Pap31 (rPap31) for the detection of antibodies against B. bacilliformis as compared with immunofluorescent assay (IFA). Of the 302 sera collected between 1997 and 2000 among an at-risk Peruvian population, 103 and 34 samples tested positive for IFA-immunoglobulin G (IgG) and IFA-IgM, respectively. By using Youden's index, the cutoff values of ELISA-IgG at 0.915 gave a sensitivity of 84.5% and specificity of 94%. The cutoff values of ELISA-IgM at 0.634 gave a sensitivity of 88.2% and specificity of 85.1%. Using latent class analysis, estimates of sensitivity and specificity of almost all the assays were slightly higher than those of a conventional method of calculation. The test is proved beneficial for discriminating between infected and non-infected individuals with the advantage of low-cost and high-throughput capability. PMID:24515944

  11. Soil as a Sustainable Resource for the Bioeconomy - BonaRes

    Science.gov (United States)

    Wollschläger, Ute; Amelung, Wulf; Brüggemann, Nicolas; Brunotte, Joachim; Gebbers, Robin; Grosch, Rita; Heinrich, Uwe; Helming, Katharina; Kiese, Ralf; Leinweber, Peter; Reinhold-Hurek, Barbara; Veldkamp, Edzo; Vogel, Hans-Jörg; Winkelmann, Traud

    2017-04-01

    Fertile soils are a fundamental resource for the production of biomass and provision of food and energy. A growing world population and latest climate targets lead to an increasing demand for bio-based products which require preserving and - ideally - improving the long-term productivity of soils as a bio-economic resource. At the same time, other soil functions and ecosystem services need to be maintained: filter for clean water, carbon sequestration, provision and recycling of nutrients, and habitat for biological activity. All these soil functions result from the interaction of a multitude of physical, chemical and biological processes which are insufficiently understood. In addition, we lack understanding about the interplay between the socio-economic system and the soil system and how soil functions benefit human wellbeing, including SDGs. However, a solid and integrated assessment of soil quality requires the consideration of the ensemble of soil functions and its relation to soil management. To make soil management sustainable, we need to establish a scientific knowledge base of complex soil system processes that allows for developing models and tools to quantitatively predict the impact of a multitude of management measures on soil functions. This will finally allow for the provision of options for a site-specific, sustainable soil management. To face this challenge, the German Federal Ministry of Education and Research (BMBF) recently launched the funding program "Soil as a Sustainable Resource for the Bioeconomy - BonaRes". In a joint effort, ten collaborative projects and the coordinating BonaRes Centre are engaged to close existing knowledge gaps for a profound and systemic assessment and understanding of soil functions and their sensitivity to soil management. In BonaRes, the complete process chain of sustainable soil use in the context of a sustainable bio-economy is being addressed: from understanding of soil processes using state-of the art and

  12. The occupational roles of women with anorexia nervosa Los papeles ocupacionales de mujeres con anorexia nervosa Os papéis ocupacionais de mulheres com anorexia nervosa

    Directory of Open Access Journals (Sweden)

    Leila Maria Quiles-Cestari

    2012-04-01

    configuram os papéis ocupacionais de pessoas com anorexia nervosa. A casuística foi composta por 11 mulheres adultas, diagnosticadas em tratamento no grupo de assistência em transtornos alimentares de um hospital de Ribeirão Preto, Brasil, e por um grupo-controle. Foram coletados dados sociodemográficos, antropométricos e aplicada a Lista de Identificação de Papéis Ocupacionais. Os resultados mostraram que houve alteração significativa nas mulheres com anorexia nervosa, com perda de papéis em relação ao padrão de desempenho do papel de trabalhador, voluntário, amigo e passatempo/amador, corroborando os prejuízos psicossociais decorrentes desse transtorno mental. A avaliação dos papéis ocupacionais no tratamento dos transtornos alimentares é estratégia importante para o planejamento de atividades de Terapia Ocupacional, fornecendo subsídios para a construção de espaços mais saudáveis, onde o fazer cria possibilidades de resgate dos papéis ocupacionais, independência e autonomia.

  13. Capacity Optimization of Renewable Energy Sources and Battery Storage in an Autonomous Telecommunication Facility

    DEFF Research Database (Denmark)

    Dragicevic, Tomislav; Pandžić, Hrvoje; Škrlec, Davor

    2014-01-01

    This paper describes a robust optimization approach to minimize the total cost of supplying a remote telecommunication station exclusively by renewable energy sources (RES). Due to the intermittent nature of RES, such as photovoltaic (PV) panels and small wind turbines, they are normally supported...... by a central energy storage system (ESS), consisting of a battery and a fuel cell. The optimization is carried out as a robust mixed-integer linear program (RMILP), and results in different optimal solutions, depending on budgets of uncertainty, each of which yields different RES and storage capacities...

  14. Congress: 50 years of the Papanicolaou test. Istituto Superiore di Sanita`. Rome, March 30, 1995; Convegno: 50 anni di Pap test. Istituto Superiore di Sanita`. Roma, 30 marzo 1995

    Energy Technology Data Exchange (ETDEWEB)

    Branca, Margherita; Cedri, Sabina; Migliore, Giovanna [Istituto Superiore di Sanita` , Rome (Italy). Lab. di Epidemiologia e Biostatistica

    1997-12-01

    The Conference was organized to celebrate the 50th anniversary of the cervical smear test, commonly referred to as the `Pap test` after its creator, George Nicholas Papanicolaou. The reports present the development of the test, its worldwide application, and its performance as the screening test for the detection of cervical cancer. Pap smear screening for precursors of carcinoma of the cervix has led to dramatic decrease in the incidence and deaths from this cancer. The test represents one of the greatest achievements in preventive medicine.

  15. Development of silica nanoparticles obtaintion process from renewable source waste and its incorporation in thermoplastic polymer for manufacturing a nanocomposite; Denvolvimento de processo de obtenção de nanopartículas de sílica a partir de resíduo de fonte renovável e incorporação em polímero termoplástico para a fabricação de nanocompósito

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz, Angel Visentim

    2016-07-01

    The nanocomposite technology is applicable to a wide range of thermoplastic and thermoset polymers. The use of sugar cane byproducts has been extensively studied as a source of reinforcement for nanocomposites. The bagasse is widely used in cogeneration and as a result of the burning of this material, millions of tons of ash are produced. For this work, silica contained in the ashes of bagasse from sugarcane was extracted by chemical method and thermal method. The thermal method is more efficient leading to a purity of more than 93% of silica, while the chemical method generated silica contaminated with chlorine and sodium from the extraction reagents. The silica particles obtained were evaluated by dynamic light scattering (DSL) and presented an average size of 12 micrometers. These particles were submitted to grinding in a ball mill and then to a sonochemical treatment. Silica particles treated by the sonochemical process ( 20 kHz, 500 W and 90 minutes) had its dimensions reduced to nanometric scale of tenths of nanometers. The nanossílica obtained was then used as reinforcement in high density polyethylene (HDPE). Mechanical and thermo-mechanical properties were assessed and gains were shown for mechanical properties , except for the impact resistance. The distortion temperature (HDT) showed that the incorporation of the reinforcement in HDPE led to a small increase in this property compared to pure HDPE. The crystallinity of the nanocomposites generated was evaluated by differential scanning calorimetry (DSC) and it was observed a decrease of crystallinity in the material when the reinforcing incorporation was 3%. The material irradiated to 250 kGy with electron beam showed important property gains, mainly due to the high level of crosslinking of irradiated HDPE. (author)

  16. Gerenciamento de resíduos odontológicos no serviço público

    Directory of Open Access Journals (Sweden)

    Lídia Regina da Costa Hidalgo

    Full Text Available OBJETIVO: Verificar o processo de gerenciamento dos resíduos odontológicos do serviço público de saúde em 11 municípios brasileiros. MATERIAL E MÉTODO: Uma única pesquisadora realizou as visitas e as observações foram anotadas em um roteiro previamente elaborado e testado. RESULTADO: Foram visitadas 50 unidades de saúde, sendo que nenhuma apresentou cópia do plano de gerenciamento de resíduos. Do total de estabelecimentos, 62% realizavam a correta segregação dos resíduos no momento da sua geração. A presença de recipientes adequados a cada tipo de resíduo gerado no consultório odontológico foi observada em 74% dos estabelecimentos e, destes, 94% apresentavam capacidade adequada ao tipo de resíduo gerado. A identificação do tipo de resíduo nas embalagens plásticas bem como anotações identificando o estabelecimento gerador dos resíduos foram encontradas em 8% e 6%, respectivamente. Somente 21% dos estabelecimentos apresentavam locais apropriados, de acordo com as normas vigentes, para o armazenamento dos resíduos até que fosse feita a coleta externa. CONCLUSÃO: Constatou-se na presente pesquisa que a rotina adotada pela rede pública de saúde bucal, no que tange ao gerenciamento de resíduos de saúde, apresentou falhas.

  17. Les Dynamiques Transfrontalières En Afrique De L'ouest

    International Development Research Centre (IDRC) Digital Library (Canada)

    Si l'approche « classique » de l'intégration régionale, qui a jusqu'à ... mettre en exergue une réalité territoriale matérialisée par l'existence d'une frontière ...... La demande alimentaire des métropoles côtières stimule ainsi la production des ...

  18. EPRI/NRC-RES fire PRA guide for nuclear power facilities. Volume 1, summary and overview

    International Nuclear Information System (INIS)

    2004-01-01

    This report documents state-of-the-art methods, tools, and data for the conduct of a fire Probabilistic Risk Assessment (PRA) for a commercial nuclear power plant (NPP) application. The methods have been developed under the Fire Risk Re-quantification Study. This study was conducted as a joint activity between EPRI and the U. S. NRC Office of Nuclear Regulatory Research (RES) under the terms of an EPRI/RES Memorandum of Understanding (RS.1) and an accompanying Fire Research Addendum (RS.2). Industry participants supported demonstration analyses and provided peer review of this methodology. The documented methods are intended to support future applications of Fire PRA, including risk-informed regulatory applications. The documented method reflects state-of-the-art fire risk analysis approaches. The primary objective of the Fire Risk Study was to consolidate recent research and development activities into a single state-of-the-art fire PRA analysis methodology. Methodological issues raised in past fire risk analyses, including the Individual Plant Examination of External Events (IPEEE) fire analyses, have been addressed to the extent allowed by the current state-of-the-art and the overall project scope. Methodological debates were resolved through a consensus process between experts representing both EPRI and RES. The consensus process included a provision whereby each major party (EPRI and RES) could maintain differing technical positions if consensus could not be reached. No cases were encountered where this provision was invoked. While the primary objective of the project was to consolidate existing state-of-the-art methods, in many areas, the newly documented methods represent a significant advancement over previously documented methods. In several areas, this project has, in fact, developed new methods and approaches. Such advances typically relate to areas of past methodological debate.

  19. Resíduos de aves e suínos: Potencialidades

    Directory of Open Access Journals (Sweden)

    Tiago Luan Hachmann

    2014-05-01

    Full Text Available O crescimento intenso da população mundial aumenta a demanda por alimentos. As carnes de frango e de suíno são as fontes mais exploradas de proteína na alimentação humana. Porém, com os métodos intensivos de produção, esses sistemas tem gerado insatisfação quanto ao aspecto ambiental e tem sido questionados quanto à sua sustentabilidade. A disposição inadequada dos resíduos gerados nos criatórios de suínos e aves afeta diretamente a qualidade do meio ambiente e a saúde pública. Assim deve-se buscar alternativas para minimizar os impactos causados ao meio, melhorando o aproveitamento e destinação desses resíduos. A aplicação desses resíduos nas áreas de produção agrícola é favorável à, tendo em vista que são uma fonte de nutrientes de grande demanda pelas culturas. Além disso é uma forma sustentável para destinação dos resíduos, já que promove seu reaproveitamento de forma a não poluir o ambiente e com alto retorno econômico. Dessa forma é possível aliar preservação ambiental com progresso econômico, promovendo uma produção sustentável.

  20. Bajenu Gox : une approche communautaire pour la santé des mères ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    initiative de Bajenu Gox à l'amélioration de la santé des mères et des enfants dans tout le Sénégal. L'ancien président Abdoulye Wade a fondé ce programme communautaire destiné aux travailleurs de la santé en vue de donner à des femmes ...

  1. Culture et exercice du pouvoir par les femmes dans les sphères de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Culture et exercice du pouvoir par les femmes dans les sphères de décisions en Afrique de l'Ouest. Cette recherche s'inscrit dans le contexte d'une superposition de deux faits : l'existence d'un arsenal juridique et de dispositions nationales et internationales favorables à une intégration des femmes dans les instances de ...

  2. Strategy for utilisation of renewable energy sources in the Republic of Macedonia by 2020

    International Nuclear Information System (INIS)

    2010-08-01

    The global commitment to environmental protection and in particular to reduction of greenhouse gas emissions, Macedonian's dependence on energy imports, as well as the need to secure greater variety and thereby reliability of energy supply undoubtedly impose increased share of renewable energy sources in the final energy consumption. however, in parallel with activities and measures targeting increased share of renewable energy sources, measures and activities to increase energy efficiency of final energy consumption should be pursued. thus, the target share of renewable energy sources in final consumption will be achieved much easily and faster, but the economy's competitiveness will also be improved due to reduced energy costs. in preparation to transpose and implement the Eu legislation (acquis communautaire) on renewable energy sources into the national legislation, the main objective of the present strategy is to provide information on the potential and possible exploitation of renewable energy sources (hereinafter: res) in the republic of macedonia. quantification of such knowledge shall be made by determining the following: - target share in total energy (res target), which is share of energy generated from res in the total energy consumption; - target share of electricity (res electricity target), which is share of electricity generated from res in the total electricity consumption; - manner and dynamics of attaining res target and res electricity target by addressing the following issues: - relevant types of res in the republic of macedonia and their availability; - primary and secondary legislation and institutional set-up ; - financial implications from the establishment of mechanisms to support use of res (feed-in tariffs); - environmental aspects, by means of analysis on possible greenhouse gas emission reduction. furthermore, in the light of secondary legislation on res, the present strategy undertakes relevant analyses aimed to determine: - installed

  3. The Response Regulator ResD Plays a Role in Metabolism of Listeria monocytogenes

    DEFF Research Database (Denmark)

    Larsen, Marianne Halberg; Sørensen, Martine; Ingmer, Hanne

    to be transmitted to food processing plants from where it can establish and survive for extended periods of time contaminating processed food products. Recently we have identified the response regulator ResD of L. monocytogenes and showed that it is important for growth in laboratory media and for sugar uptake...... in the upstream regulatory region of several genes of L. monocytogenes and the binding of the ResD protein to some of these regulatory regions upstream putative target genes is analysed by electrophoretic mobility shift assays (EMSAs). In conclusion, the response regulator ResD act is important for metabolisme...

  4. Valorização de resíduos em materiais de construção

    OpenAIRE

    Pinho, Paulo André Martins de

    2014-01-01

    O trabalho desenvolvido nesta dissertação enquadra-se no objetivo geral de valorização de resíduos provenientes de unidades de pasta Kraft de eucalipto, nomeadamente cinzas de fundo e cinzas volantes das fornalhas de biomassa. Atualmente uma das mais graves preocupações das sociedades dos países desenvolvidos passa por encontrar um destino adequado para resíduos gerados. A construção civil, aliada com a indústria da produção de pasta e papel que por ano gera milhares de toneladas de resídu...

  5. Heterozygous Mutations in TREX1 Cause Familial Chilblain Lupus and Dominant Aicardi-Goutières Syndrome

    Science.gov (United States)

    Rice, Gillian; Newman, William G.; Dean, John; Patrick, Teresa; Parmar, Rekha; Flintoff, Kim; Robins, Peter; Harvey, Scott; Hollis, Thomas; O’Hara, Ann; Herrick, Ariane L.; Bowden, Andrew P.; Perrino, Fred W.; Lindahl, Tomas; Barnes, Deborah E.; Crow, Yanick J.

    2007-01-01

    TREX1 constitutes the major 3′→5′ DNA exonuclease activity measured in mammalian cells. Recently, biallelic mutations in TREX1 have been shown to cause Aicardi-Goutières syndrome at the AGS1 locus. Interestingly, Aicardi-Goutières syndrome shows overlap with systemic lupus erythematosus at both clinical and pathological levels. Here, we report a heterozygous TREX1 mutation causing familial chilblain lupus. Additionally, we describe a de novo heterozygous mutation, affecting a critical catalytic residue in TREX1, that results in typical Aicardi-Goutières syndrome. PMID:17357087

  6. European Union's renewable energy sources and energy efficiency policy review. The Spanish perspective

    Energy Technology Data Exchange (ETDEWEB)

    De Alegria Mancisidor, Itziar Martinez; Diaz de Basurto Uraga, Pablo; Ruiz de Arbulo Lopez, Patxi [Departamento de Organizacion de Empresas, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (Spain); Martinez de Alegria Mancisidor, Inigo [Departamento de Electronica y Telecomunicaciones, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (Spain)

    2009-01-15

    The European Union's (EU) energy objectives, legislation and programmes are determinant for the current strategy for the promotion of renewable energy sources (RES) and energy efficiency (EE) in Spain, which is becoming a key element for its international competitiveness. Firstly, this article explores the evolution of the EU's energy strategy, focusing on the adopted legislations and programmes to promote RES and EE. It concludes with an analysis of the impact of those measures in Spain. (author)

  7. European Union's renewable energy sources and energy efficiency policy review. The Spanish perspective

    International Nuclear Information System (INIS)

    De Alegria Mancisidor, Itziar Martinez; Diaz de Basurto Uraga, Pablo; Ruiz de Arbulo Lopez, Patxi; Martinez de Alegria Mancisidor, Inigo

    2009-01-01

    The European Union's (EU) energy objectives, legislation and programmes are determinant for the current strategy for the promotion of renewable energy sources (RES) and energy efficiency (EE) in Spain, which is becoming a key element for its international competitiveness. Firstly, this article explores the evolution of the EU's energy strategy, focusing on the adopted legislations and programmes to promote RES and EE. It concludes with an analysis of the impact of those measures in Spain. (author)

  8. US defensive operations against Libya and the nuclear accident at Chernobyl. Markup before the Committee on Foreign Affairs, House of Representatives, Ninety-Ninth Congress, Second Session on H. Res. 424 and H. Res 440, May 1, 1986

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The House Foreign Affairs Committee met to mark up two resolutions: H. Res. 424 and H. Res. 440. H. Res. 424 thanks the United Kingdom for its assistance in the April 14, 1986 operation against Libya. Despite objections to the raid and to including the British, as well as questions about the quality of the US response and about the President's compliance with the Constitution and the War Powers Resolution, the resolution passed. H. Res. 440 expresses sympathy to the victims of the Chernobyl accident and asks the Soviet Union to relax restrictions on communications and the transfer of whatever technology and assistance will be helpful. It also criticizes the Soviet handling of information about the accident. An amendment strengthened the wording of the criticism, and the resolution passed. The report includes the committee discussion and the tests of the two resolutions

  9. Relation entre la faune de quelques rivières du nord-ouest de l'Angleterre et les activités humaines

    Directory of Open Access Journals (Sweden)

    MACAN T. T.

    1976-01-01

    Full Text Available MINSHALL et KUEHNE ont signalé que, dans la « Région des lacs » en Angleterre, alors que la faune typique d'un ruisseau à fond pierreux peut monter jusqu'aux sources dans les montagnes, il y a des zones où la faune est pauvre, hormis les Plécoptères. Dans ces dernières eaux, le pH et le taux en calcium sont faibles, comme l'ont montré SUTCLIFFE et CARRICK qui pensent qu'il s'agit d'une pollution atmosphérique. De telles communautés habitent les affluents de la Rivière Lune. La rivière elle-même traverse une gorge où, grâce aux éboulis, le fond est stable. La faune actuelle est riche en espèces et en individus, surtout en larves de Tricoptères avec filet. C'est presque la seule région où les mollusques ne risquent pas d'être écrasés par les pierres roulantes. En aval, dans une longue plaine alluviale, le substrat est instable et, en conséquence, les espèces sont peu nombreuses bien que les individus de quelques-unes soient abondants. Une augmentation de l'enrichissement actuel provenant des villes et des prairies cultivées pourrait provoquer une croissance excessive des algues filamenteuses. Celles-ci font disparaître la vraie faune lithicole et disparaissent elles-mêmes en temps de crue, en emportant vers l'aval les animaux qu'elles hébergent. Au-delà de la plaine, la rivière traverse une région à pierre meulière, sur un lit plat et lisse. Entre deux barrages, ce lit est couvert de mousses habitées par 4 espèces d'éphémères qui ne se trouvent ailleurs, que dans de petites baies où le courant est faible. On a remarqué dans une rivière voisine la disparition de telles espèces après l'amélioration du lit par les ingénieurs.

  10. Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, Belgium

    Directory of Open Access Journals (Sweden)

    Alex Vorsters

    2016-06-01

    Full Text Available Abstract Background Although female sex workers (FSWs are a well-known high-risk group for Human Papillomavirus (HPV infections, few tailored intervention programmes for HPV have been established worldwide. The lack of reliable data on the prevalence of HPV and related cervical lesions hampers the establishment of evidence-based intervention programmes. The objectives of this study were to describe the prevalence of high-risk Human Papillomavirus (hrHPV infections and abnormal pap smears in FSWs compared to a control group in Antwerp, Belgium. Methods HPV genotyping and cytology data were analysed from routine Pap smear tests that were collected from both FSWs and the general population (1334 samples for each group between June 2006 and June 2010. Within the laboratory database, all FSWs were matched 1:1 for age and testing date to determine the ORs of hrHPV genotypes, DNA and cytology outcome. Results The prevalence of hrHPV DNA in FSWs was 41.7 % compared to 19.8 % in the age-matched controls with an overall OR of 2.8 (95 % CI: 2.3–3.4. Significant differences were observed in all age groups, and the most significant differences were observed in the cohort under 21 years of age (prevalence of 64.4 % in FSWs versus 14.8 % in controls; OR 10.3 (95 % CI: 5.0–21.2. Significantly more cervical lesions were observed in FSWs, particularly in the 17- to 21-year old age group (OR for LSIL or HSIL: 10.3 (95 % CI: 3.2–33.8. In both groups, HPV 16 was the most prevalent at 12.1 and 6.6 % in the FSW and control groups, respectively. HPV 18 was the 8th and 7th most frequent genotype at 5.0 and 2.5 % in the FSW and control groups, respectively. Conclusions FSWs have a significantly higher prevalence of hrHPV and more abnormal Pap smears than does the general population in Antwerp, Belgium. The hrHPV prevalence in FSWs is similar to that reported in the literature. The need for tailored intervention programmes should be investigated further.

  11. Using probabilistic record linkage methods to identify Australian Indigenous women on the Queensland Pap Smear Register: the National Indigenous Cervical Screening Project.

    Science.gov (United States)

    Whop, Lisa J; Diaz, Abbey; Baade, Peter; Garvey, Gail; Cunningham, Joan; Brotherton, Julia M L; Canfell, Karen; Valery, Patricia C; O'Connell, Dianne L; Taylor, Catherine; Moore, Suzanne P; Condon, John R

    2016-02-12

    To evaluate the feasibility and reliability of record linkage of existing population-based data sets to determine Indigenous status among women receiving Pap smears. This method may allow for the first ever population measure of Australian Indigenous women's cervical screening participation rates. A linked data set of women aged 20-69 in the Queensland Pap Smear Register (PSR; 1999-2011) and Queensland Cancer Registry (QCR; 1997-2010) formed the Initial Study Cohort. Two extracts (1995-2011) were taken from Queensland public hospitals data (Queensland Hospital Admitted Patient Data Collection, QHAPDC) for women, aged 20-69, who had ever been identified as Indigenous (extract 1) and had a diagnosis or procedure code relating to cervical cancer (extract 2). The Initial Study Cohort was linked to extract 1, and women with cervical cancer in the initial cohort were linked to extract 2. The proportion of women in the Initial Cohort who linked with the extracts (true -pairs) is reported, as well as the proportion of potential pairs that required clerical review. After assigning Indigenous status from QHAPDC to the PSR, the proportion of women identified as Indigenous was calculated using 4 algorithms, and compared. There were 28,872 women (2.1%) from the Initial Study Cohort who matched to an ever Indigenous record in extract 1 (n=76,831). Women with cervical cancer in the Initial Study Cohort linked to 1385 (71%) records in extract 2. The proportion of Indigenous women ranged from 2.00% to 2.08% when using different algorithms to define Indigenous status. The Final Study Cohort included 1,372,823 women (PSR n=1,374,401; QCR n=1955), and 5,062,118 records. Indigenous status in Queensland cervical screening data was successfully ascertained through record linkage, allowing for the crucial assessment of the current cervical screening programme for Indigenous women. Our study highlights the need to include Indigenous status on Pap smear request and report forms in any

  12. Les sources des Citations peintes sur les phylactères des Saints de la rangée inférieure de la façade de l’Eglise de La Résurrection de Dieu du Monastère de Suceviţa / The Sources of the Quotations Painted on the Phylacteries of the Saints of the Lower Row of the Façade of the Church of the Resurrection of God of the Monastery of Suceviţa

    Directory of Open Access Journals (Sweden)

    Constantin I. Ciobanu

    2015-11-01

    Full Text Available The Sources of the Quotations Painted on the Phylacteries of the Saints of the Lower Row of the Façade of the Church of the Resurrection of God of the Monastery of Suceviţa. This study aims to discover the literary sources of the quotations painted on the phylacteries of the saints on the bottom row of the regarding the façade of the Church of the Resurrection of Christ of Suceviţa Monastery. This study is part of a series regarding the sayings of the fathers from the desert, the confessors, the anchorites and the stylites painted on the southern façade of the Church of The Annunciation of the Virgin from Moldoviţa . The author of the study shows that the quotes from Suceviţa are largely drawn from the Alphabetical Collection of the Sentences of the Fathers of the Desert.

  13. Exploration of renewable sources for isolated systems

    OpenAIRE

    Apolo, Cristhian Agustin Apolo

    2017-01-01

    Providing universal access to electricity is a priority worldwide. Renewable Energy Sources (RES) play an important role in the supply of energy to rural and remote areas, where grid electricity is not available, or the cost of the grid extension is excessively. Isolated communities in the Amazon region of Ecuador are frequently far away from each other, formed by scattered housing, exhibit very low population density, and are surrounded by dense vegetation. Supplying such communities is typi...

  14. Uso de resíduos de gesso como corretivo em solo salino-sódico

    OpenAIRE

    Santos, Paulo Medeiros dos; Rolim, Mario Monteiro; Duarte, Anamaria Sousa; Barros, Maria de Fátima Cavalcanti; Silva, Ênio Farias de França e

    2014-01-01

    Um dos grandes problemas enfrentados pelo setor da construção civil é a destinação final de resíduos, principalmente os resíduos de gesso, que têm sua aptidão para reciclagem restringida. No entanto, tais resíduos possuem altos teores de cálcio, em sua composição, podendo ser uma alternativa ao uso de gesso de jazida, na recuperação de solos salino-sódicos. Esta pesquisa objetivou avaliar a eficiência do uso de resíduos de gesso provenientes da construção civil, em relação ao gesso de jazida,...

  15. First record of the genus Spinaethorax Papáč & Palacios-Vargas, 2016 (Collembola, Neelipleona, Neelidae in Asia, with a new species from a Vietnamese cave.

    Directory of Open Access Journals (Sweden)

    Clément Schneider

    2017-10-01

    Full Text Available A new species of the genus Spinaethorax Papáč & Palacios-Vargas, 2016, recently erected for two cave species of Mexico, is described from a Vietnamese cave. It differs from the Mexican species most noticeably by the dorsal chaetotaxy of the head (number and morphology of chaetae, the shape of S-chaetae on the third antennomere, the dorsal chaetotaxy of the abdomen and the chaetotaxy of the dens. The pattern of special τ-chaetae is described for the first time in the genus. The affinities between Spinaethorax and the other genera of Neelipleona are discussed. Spinaethorax is probably closely related to Neelus Folsom, 1896. A table of the differential characters is provided for the three known species of Spinaethorax. Spinaethorax appears to be restricted to caves, but its presence in Vietnam indicates that this genus has a much larger distribution than previously recognized.

  16. Saliência de papéis e stresse profissional numa amostra de professores : comparações inter-geracionais

    OpenAIRE

    Martins, Carla Renata Alves

    2012-01-01

    Tese de mestrado, Psicologia (Secção de Psicologia dos Recursos Humanos, do Trabalho e das Organizações), Universidade de Lisboa, Faculdade de Psicologia, 2012 A presente investigação insere-se no âmbito do estudo da saliência de papéis e do stresse profissional, com o objectivo de comparar três gerações: a Geração Baby Boomer, a Geração X e a Geração Y. A amostra é constituída por 68 professores do ensino básico e secundário. Os instrumentos utilizados foram o Inventário sobre a Saliência...

  17. Innovation pour la santé des mères et des enfants d'Afrique | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'initiative Innovation pour la santé des mères et des enfants d'Afrique (ISMEA) cherche à améliorer la santé des mères, des nouveau-nés et des enfants en ... Cette initiative de 36 millions de dollars sur sept ans – financée conjointement par les Instituts de recherche en santé du Canada, Affaires mondiales Canada et le ...

  18. Mobilidade de metais pesados em solo tratado com resíduo siderúrgico ácido

    Directory of Open Access Journals (Sweden)

    N. M. B. Amaral Sobrinho

    1998-06-01

    Full Text Available Amostras do horizonte Bt de um Podzólico Vermelho-Amarelo (PV, predominante no aterro-piloto de resíduos industriais (ARSI da Companhia Siderúrgica Nacional (CSN, foram acondicionadas, em 1992, em colunas de vidro com 5,4 cm de diâmetro e 37 cm de altura. Sobre essas amostras de solo foram colocadas amostras de um resíduo ácido da CSN na proporção solo-resíduo de 4:1 (conforme a concepção básica do projeto do ARSI. Tal sistema resíduo-solo foi lixiviado com 50 volumes-poro de água deionizada, com pH 4,5, com o objetivo de avaliar a movimentação de Cr, Mn, Ni, Cu, Zn, Cd e Pb nas colunas. Depois da lixiviação, removeu-se o resíduo do topo das colunas, e seccionaram-se as amostras de solo em 4 partes iguais. Os metais pesados das amostras do resíduo e do solo foram extraídos seqüencialmente. 0 Pb, Cu e Cr mobilizados do resíduo ficaram retidos nos primeiros 5 cm da coluna de solo. 0 Zn, Mn, Ni e Cd tiveram aumento da concentração em profundidade. Nos efluentes das colunas com o resíduo, foram observadas concentrações de Mn e Ni bem superiores aos padrões permitidos pela Fundação Estadual de Engenharia do Meio Ambiente (FEEMA, 1985.

  19. 195 Evaluation de la charge polluante des rivières des eaux usées ...

    African Journals Online (AJOL)

    kapepula

    ressources financières des pouvoirs publics au niveau local et l'absence de réelles politiques environnementales sont parmi les ... sont collectés vers les quatre rivières. Généralement les aides de la gestion des déchets adéquates protègent la santé humaine et l'environnement et conserve les ressources naturelles [3].

  20. Modeling of an autonomous microgrid for renewable energy sources integration

    DEFF Research Database (Denmark)

    Serban, I.; Teodorescu, Remus; Guerrero, Josep M.

    2009-01-01

    The frequency stability analysis in an autonomous microgrid (MG) with renewable energy sources (RES) is a continuously studied issue. This paper presents an original method for modeling an autonomous MG with a battery energy storage system (BESS) and a wind power plant (WPP), with the purpose...

  1. The Pap smear screening as an occasion for smoking cessation and physical activity counselling: baseline characteristics of women involved in the SPRINT randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Chellini Elisabetta

    2011-12-01

    Full Text Available Abstract Background Gender-specific smoking cessation strategies have rarely been developed. Evidence of effectiveness of physical activity (PA promotion and intervention in adjunct to smoking cessation programs is not strong. SPRINT study is a randomized controlled trial (RCT designed to evaluate a counselling intervention on smoking cessation and PA delivered to women attending the Italian National Health System Cervical Cancer Screening Program. This paper presents study design and baseline characteristics of the study population. Methods/Design Among women undergoing the Pap examination in three study centres (Florence, Turin, Mantua, participants were randomized to the smoking cessation counselling [S], the smoking cessation + PA counselling [S + PA], or the control [C] groups. The program under evaluation is a standard brief counselling on smoking cessation combined with a brief counselling on increasing PA, and was delivered in 2010. A questionnaire, administered before, after 6 months and 1 year from the intervention, was used to track behavioural changes in tobacco use and PA, and to record cessation rates in participants. Discussion Out of the 5,657 women undergoing the Pap examination, 1,100 participants (55% of smokers were randomized in 1 of the 3 study groups (363 in the S, 366 in the S + PA and 371 in the C groups. The three arms did not differ on any demographic, PA, or tobacco-use characteristics. Recruited smokers were older, less educated than non-participant women, more motivated to quit (33% vs.9% in the Preparation stage, p p p Trial registration number ISRCTN: ISRCTN52660565

  2. Additional collection devices used in conjunction with the SurePath Liquid-Based Pap Test broom device do not enhance diagnostic utility

    Directory of Open Access Journals (Sweden)

    O'Connor Jason C

    2004-09-01

    Full Text Available Abstract Background We have previously shown that use of an EC brush device in combination with the Rovers Cervex-Brush (SurePath broom offered no significant improvement in EC recovery. Here we determine if use of additional collection devices enhance the diagnostic utility of the SurePath Pap for gynecologic cytology. Methods After informed consent, 37 women ages 18–56 receiving their routine cervical examinations were randomized into four experimental groups. Each group was first sampled with the SurePath broom then immediately re-sampled with an additional collection device or devices. Group 1: Rover endocervix brush (n = 8. Group 2: Medscand CytoBrush Plus GT (n = 7. Group 3: Rover spatula + endocervix brush (n = 11. Group 4: Medscand spatula + CytoBrush Plus GT (n = 11. Results Examination of SurePath broom-collected cytology yielded the following abnormal diagnoses: atypia (n = 2, LSIL (n = 5 and HSIL (n = 3. Comparison of these diagnoses to those obtained from paired samples using the additional collection devices showed that use of a second and or third device yielded no additional abnormal diagnoses. Importantly, use of additional devices did not improve upon the abnormal cell recovery of the SurePath broom and in 4/10 cases under-predicted or did not detect the SurePath broom-collected lesion as confirmed by cervical biopsy. Finally, in 36/37 cases, the SurePath broom successfully recovered ECs. Use of additional devices, in Group 3, augmented EC recovery to 37/37. Conclusions Use of additional collection devices in conjunction with the SurePath broom did not enhance diagnostic utility of the SurePath Pap. A potential but not significant improvement in EC recovery might be seen with the use of three devices.

  3. El príncipe destronado (Miguel Delibes, 1973/La guerra de papá (Antonio Mercero, 1977, and third way spanish cinema

    Directory of Open Access Journals (Sweden)

    Faulkner, Sally

    2011-04-01

    Full Text Available This articles examines Daddy’s War as an example of Third Way cinema, and considers the reasons for its box office success. First, it compares Delibes’s original novel with the film version. Above all, it considers the use of the child’s point of view (underlined in Delibes’s title and the treatment of the Spanish Civil War (the focus of Mercero’s title. After analysing Daddy’s War in the context of contemporary Spanish auteur and commercial cinemas, it concludes that Mercero finds a half-way house between both tendencies that was enjoyed by audiences. Thus, the film is an example of Spanish middlebrow culture. Finally, the study considers the links between Delibes’s novel, Mercero’s cinema, and Spanish television today.Este artículo examina La guerra de papá como ejemplo de la Tercera Vía, y considera las razones de su éxito de taquilla. Mediante el análisis comparado de la novela original de Delibes y la versión cinematográfica de Mercero, se detiene en el uso del punto de vista infantil (subrayado en el título de Delibes y el tratamiento de la Guerra Civil (focalizado en el título de Mercero. Tras analizar La guerra de papá en el contexto del cine de autor y cine comercial contemporáneos españoles, concluye que Mercero encuentra un punto de encuentro entre ambas tendencias que explica su éxito de público como un ejemplo de la cultura media española. Por último, el estudio considera los vínculos entre la novela de Delibes, el cine de Mercero, y la televisión española de momento.

  4. Chemical Vapor Deposition Growth of Degenerate p-Type Mo-Doped ReS2 Films and Their Homojunction.

    Science.gov (United States)

    Qin, Jing-Kai; Shao, Wen-Zhu; Xu, Cheng-Yan; Li, Yang; Ren, Dan-Dan; Song, Xiao-Guo; Zhen, Liang

    2017-05-10

    Substitutional doping of transition metal dichalcogenide two-dimensional materials has proven to be effective in tuning their intrinsic properties, such as band gap, transport characteristics, and magnetism. In this study, we realized substitutional doping of monolayer rhenium disulfide (ReS 2 ) with Mo via chemical vapor deposition. Scanning transmission electron microscopy demonstrated that Mo atoms are successfully doped into ReS 2 by substitutionally replacing Re atoms in the lattice. Electrical measurements revealed the degenerate p-type semiconductor behavior of Mo-doped ReS 2 field effect transistors, in agreement with density functional theory calculations. The p-n diode device based on a doped ReS 2 and ReS 2 homojunction exhibited gate-tunable current rectification behaviors, and the maximum rectification ratio could reach up to 150 at V d = -2/+2 V. The successful synthesis of p-type ReS 2 in this study could largely promote its application in novel electronic and optoelectronic devices.

  5. Loading Intensity Prediction by Velocity and the OMNI-RES 0-10 Scale in Bench Press.

    Science.gov (United States)

    Naclerio, Fernando; Larumbe-Zabala, Eneko

    2017-02-01

    Naclerio, F and Larumbe-Zabala, E. Loading intensity prediction by velocity and the OMNI-RES 0-10 scale in bench press. J Strength Cond Res 32(1): 323-329, 2017-This study examined the possibility of using movement velocity and the perceived exertion as indicators of relative load in the bench press (BP) exercise. A total of 308 young, healthy, resistance trained athletes (242 men and 66 women) performed a progressive strength test up to the one repetition maximum for the individual determination of the full load-velocity and load-exertion relationships. Longitudinal regression models were used to predict the relative load from the average velocity (AV) and the OMNI-Resistance Exercise Scales (OMNI-RES 0-10 scale), considering sets as the time-related variable. Load associated with the AV and the OMNI-RES 0-10 scale value expressed after performing a set of 1-3 repetitions were used to construct 2 adjusted predictive equations: Relative load = 107.75 - 62.97 × average velocity; and Relative load = 29.03 + 7.26 × OMNI-RES 0-10 scale value. The 2 models were capable of estimating the relative load with an accuracy of 84 and 93%, respectively. These findings confirm the ability of the 2 calculated regression models, using load-velocity and load-exertion from the OMNI-RES 0-10 scale, to accurately predict strength performance in BP.

  6. Polytypism and unexpected strong interlayer coupling in two-dimensional layered ReS2

    Science.gov (United States)

    Qiao, Xiao-Fen; Wu, Jiang-Bin; Zhou, Linwei; Qiao, Jingsi; Shi, Wei; Chen, Tao; Zhang, Xin; Zhang, Jun; Ji, Wei; Tan, Ping-Heng

    2016-04-01

    Anisotropic two-dimensional (2D) van der Waals (vdW) layered materials, with both scientific interest and application potential, offer one more dimension than isotropic 2D materials to tune their physical properties. Various physical properties of 2D multi-layer materials are modulated by varying their stacking orders owing to significant interlayer vdW coupling. Multilayer rhenium disulfide (ReS2), a representative anisotropic 2D material, was expected to be randomly stacked and lack interlayer coupling. Here, we demonstrate two stable stacking orders, namely isotropic-like (IS) and anisotropic-like (AI) N layer (NL, N > 1) ReS2 are revealed by ultralow- and high-frequency Raman spectroscopy, photoluminescence and first-principles density functional theory calculation. Two interlayer shear modes are observed in AI-NL-ReS2 while only one shear mode appears in IS-NL-ReS2, suggesting anisotropic- and isotropic-like stacking orders in IS- and AI-NL-ReS2, respectively. This explicit difference in the observed frequencies identifies an unexpected strong interlayer coupling in IS- and AI-NL-ReS2. Quantitatively, the force constants of them are found to be around 55-90% of those of multilayer MoS2. The revealed strong interlayer coupling and polytypism in multi-layer ReS2 may stimulate future studies on engineering physical properties of other anisotropic 2D materials by stacking orders.Anisotropic two-dimensional (2D) van der Waals (vdW) layered materials, with both scientific interest and application potential, offer one more dimension than isotropic 2D materials to tune their physical properties. Various physical properties of 2D multi-layer materials are modulated by varying their stacking orders owing to significant interlayer vdW coupling. Multilayer rhenium disulfide (ReS2), a representative anisotropic 2D material, was expected to be randomly stacked and lack interlayer coupling. Here, we demonstrate two stable stacking orders, namely isotropic-like (IS) and

  7. A method for allocating renewable energy source subsidies among final energy consumers

    International Nuclear Information System (INIS)

    Batlle, Carlos

    2011-01-01

    In a new context of growing need for renewable energy sources (RES), tariff design has become a critical component of energy system regulation. A methodology for allocating the cost of RES subsidies that ensures an optimal balance between compliance with the main regulatory principles of tariff design and each state's specific policy is of cardinal importance in the current context. This paper presents and discusses a novel methodology to allocate the RES subsidy costs, which consists of distributing them among final energy consumers, in proportion to their consumption, regardless of the type of final energy consumed (liquid fuels, gas, electricity or coal). First, the different designs of RES subsidies are categorized and a review of a good number of the RES burden sharing mechanisms implemented in the EU is presented. Then, the proposed methodology is developed on the basis of the basic regulatory principles underlying the tariff design and the current regulatory context in force in the EU. Finally, to illustrate its actual impact in a real case example, the proposed methodology is applied to the Spanish system, in which the burden of extra costs incurred for RES amounts to a very large proportion of the overall energy system costs. - Research highlights: → This paper develops a novel methodology to allocate RES subsidy costs among final energy consumers. → The methodology is built upon the basic tariff design principles and the 3rd package regulations. → It consists of distributing them in proportion to liquid fuels, gas, electricity or coal consumption. → The 20% RES target affects all energy sectors and justifies allocating the extra costs accordingly. → The methodology is applied to the Spanish energy system, where the RES burden is a very significant.

  8. Polymères en ambiance nucléaire comportement à long terme

    CERN Document Server

    Audouin, Ludmila; Fayolle, Bruno; Richaud, Emmanuel; Verdu, Jacques

    2012-01-01

    Ce livre présente des outils théoriques originaux, indispensables pour ta prédiction de la durée de vie des matériaux polymères en ambiance nucléaire. Le problème de vieillissement des polymères est avant tout un problème d'ingénieur, dont la préoccupation majeure est la prédiction de durée de vie selon des critères pertinents du point de vue de l'application. Partant de ce constat, les auteurs ont focalisé leur intérêt sur les aspects les plus souvent négligés dans les ouvrages classiques mais cruciaux : la modélisation cinétique de l'oxydation radio-amorcée à faible débit de dose et les conséquences de l'irradiation sur les propriétés thermomécaniques. Ces deux aspects font l'objet de développements qui confèrent à l'ouvrage son originalité, lui permettant d'être un complément utile aux ouvrages classiques. Présenté de manière claire et pédagogique, cet ouvrage permettra à l'étudiant de Master, au jeune chercheur comme à l'ingénieur de rejoindre un courant de reche...

  9. The evolution of the support scheme for promoting renewable energy sources in Romania

    Directory of Open Access Journals (Sweden)

    Atănăsoae Pavel

    2016-01-01

    Full Text Available The paper presents an analysis of the evolution of the support scheme for promoting renewable energy sources in Romania, following: the annual mandatory quotas of green certificate purchase and those achieved; the price of green certificates; the evolution of the RES-E installed capacity and implicitly of the investments in renewable energy sources; the structure of the installed power in RES-E (wind power plants, photovoltaic power plants, hydroelectric power plants with an installed capacity that is not larger than 10 MW, biomass power plants; the contribution of the renewable energy sources to the production of electricity in Romania.

  10. Capitalization of renewable energy sources: Romanian case studies

    International Nuclear Information System (INIS)

    Voronca, Mihai-Marius; Cruceru, Mihai

    2007-01-01

    One of the major challenges of the recent integration of Romania in the European Union is the extension of use, at national scale, of Renewable Energy Sources (RES). Targeting private operators and municipalities, authors have as objective to deliver an investigation on the interesting 'Acquis' in financing and implementing RES projects in Romania. Using as method of investigation the accurate screening of their experience as well as the extended international experience in the field, authors have reviewed in the present paper different possibilities in RES investment financing, frequent obstacles and barriers, and ways for overcoming them. Recent results are motivating authors to consider the national experience of an encouraging success and to act towards the capitalization of such investments replication potential to a national and regional scale. (authors)

  11. Rahvaliitlaste rahalaevad roostetavad kai ääres / Sten-Aleks Pihlak

    Index Scriptorium Estoniae

    Pihlak, Sten-Aleks

    2007-01-01

    Rahvaliidule lähedal seisvad ärimehed müüsid riigile maha vanu kalalaevu, et neid õppelaevadena kasutada, kuid nüüd roostetavad laevad kai ääres. Vt. samas: Lobby ekstraklass - minister tegi kõik, mis soovitud; Kalurite liit on tänaseks laiali jooksnud; Undrest jr võitles toetuse välja kohtus; Üheksast õppelaevaks muudetud alusest õpitakse päriselt vaid mõnel. Küsimustele vastab endine põllumajandusminister Ester Tuiksoo. Kommenteerivad Toivo Orgussaar ja Jüri Lember

  12. Des compagnes, des épouses, des mères

    OpenAIRE

    Robert-Guiard, Claudine

    2017-01-01

    Compagnes, épouses et mères sont pour les femmes les rôles attendus par les hommes, voire par elles-mêmes et aussi par les États. Quand il s’agit de peupler un territoire, un gouvernement a besoin, encore plus impérativement qu’en situation normale, que les femmes remplissent au mieux ces fonctions qui leur sont traditionnellement, et génétiquement pour la maternité, dévolues. Dans ces rôles les femmes sont pratiquement indissociables de leurs enfants et de leur compagnon ou mari. Étudier les...

  13. HiRes camera and LIDAR ranging system for the Clementine mission

    Energy Technology Data Exchange (ETDEWEB)

    Ledebuhr, A.G.; Kordas, J.F.; Lewis, I.T. [and others

    1995-04-01

    Lawrence Livermore National Laboratory developed a space-qualified High Resolution (HiRes) imaging LIDAR (Light Detection And Ranging) system for use on the DoD Clementine mission. The Clementine mission provided more than 1.7 million images of the moon, earth, and stars, including the first ever complete systematic surface mapping of the moon from the ultra-violet to near-infrared spectral regions. This article describes the Clementine HiRes/LIDAR system, discusses design goals and preliminary estimates of on-orbit performance, and summarizes lessons learned in building and using the sensor. The LIDAR receiver system consists of a High Resolution (HiRes) imaging channel which incorporates an intensified multi-spectral visible camera combined with a Laser ranging channel which uses an avalanche photo-diode for laser pulse detection and timing. The receiver was bore sighted to a light-weight McDonnell-Douglas diode-pumped ND:YAG laser transmitter that emmitted 1.06 {micro}m wavelength pulses of 200 mJ/pulse and 10 ns pulse-width, The LIDAR receiver uses a common F/9.5 Cassegrain telescope assembly. The optical path of the telescope is split using a color-separating beamsplitter. The imaging channel incorporates a filter wheel assembly which spectrally selects the light which is imaged onto a custom 12 mm gated image intensifier fiber-optically-coupled into a 384 x 276 pixel frame transfer CCD FPA. The image intensifier was spectrally sensitive over the 0.4 to 0.8 {micro}m wavelength region. The six-position filter wheel contained 4 narrow spectral filters, one broadband and one blocking filter. At periselene (400 km) the HiRes/LIDAR imaged a 2.8 km swath width at 20-meter resolution. The LIDAR function detected differential signal return with a 40-meter range accuracy, with a maximum range capability of 640 km, limited by the bit counter in the range return counting clock.

  14. rendre les villes urbaines sûres et inclusives au Venezuela

    International Development Research Centre (IDRC) Digital Library (Canada)

    ont étudié ces institutions et leur lien avec le taux de criminalité et la cohésion sociale dans quatre villes : Caracas, Ciudad Guayana, San Cristóbal et San Antonio del Táchira. Leur objectif était de trouver des solutions favorisant la sécurité et l'inclusivité dans ces villes. Histoire à succès | Villes sûres et inclusiVes. FLiC kr.

  15. Technical and economic analysis of the European electricity system with 60% RES

    International Nuclear Information System (INIS)

    Burtin, Alain; Silva, Vera

    2015-01-01

    This document examines the impacts of the integration of a large share of variable renewable generation into the generation mix of the European interconnected electricity system. The analysis, which is based on the results of long term studies performed by EDF R and D, aims at improving the current understanding of the technical and economic feasibility of a massive deployment of wind and PV across the European system. The document addresses several aspects of the system integration of variable generation in particular, including the characterization of variable RES generation, the need for generation and interconnection infrastructure, the impacts on short-term system operation and market profitability. (authors)

  16. Bilan des flux de matières particulaires et dissoutes du Sassandra à ...

    African Journals Online (AJOL)

    Ce travail a pour objectif l'estimation des apports du fleuve Sassandra. C'est dans ce cadre que les flux de matières particulaires et dissoutes ont été mesurés au cours de l'année 2003 sur le fleuve Sassandra, à la station hydrométrique de Gaoulou. La méthodologie adoptée a consisté à déterminer d'abord les ...

  17. SPATIOTEMPORAL MODELING FOR ASSESSING COMPLEMENTARITY OF RENEWABLE ENERGY SOURCES IN DISTRIBUTED ENERGY SYSTEMS

    Directory of Open Access Journals (Sweden)

    L. Ramirez Camargo

    2015-07-01

    Full Text Available Spatial assessments of the potential of renewable energy sources (RES have become a valuable information basis for policy and decision-making. These studies, however, do not explicitly consider the variability in time of RES such as solar energy or wind. Until now, the focus is usually given to economic profitability based on yearly balances, which do not allow a comprehensive examination of RES-technologies complementarity. Incrementing temporal resolution of energy output estimation will permit to plan the aggregation of a diverse pool of RES plants i.e., to conceive a system as a virtual power plant (VPP. This paper presents a spatiotemporal analysis methodology to estimate RES potential of municipalities. The methodology relies on a combination of open source geographic information systems (GIS processing tools and the in-memory array processing environment of Python and NumPy. Beyond the typical identification of suitable locations to build power plants, it is possible to define which of them are the best for a balanced local energy supply. A case study of a municipality, using spatial data with one square meter resolution and one hour temporal resolution, shows strong complementarity of photovoltaic and wind power. Furthermore, it is shown that a detailed deployment strategy of potential suitable locations for RES, calculated with modest computational requirements, can support municipalities to develop VPPs and improve security of supply.

  18. Promotion of electricity produced from renewable energy sources - Strategic objective of the Romania energy policy

    International Nuclear Information System (INIS)

    Sandulescu, Alexandru; Stanciulescu, Georgeta; Jisa, Mihaela; Stanciu, Nadina

    2006-01-01

    The paper presents different types of support schemes for promoting electricity produced from renewable energy sources in some countries from European Union and details concerning the primary and secondary legislation developed in Romania in the field of promotion of electricity produced from renewable energy sources, making a rehearse of the acts issued. Romania has a clear regulatory framework in the field of promoting E-RES, the green certificates market becoming operational from November 2005, when the first green certificates transaction session organised by SC OPCOM SA took place. With hydro energy being exception from the rule, the Romanian RES potential is almost unused, existing the possibility for promotion some efficient investments in units which produce E-RES, turning to good account to the best emplacements. Although the achievements in using RES are still modest, taking into consideration the attention of numerous investors and the way that the support scheme worked until now, with advantages for the existing E-RES producers, it is expected an acceleration of the rhythm of appearance of new investments. In order to actuate the investors attention, a stronger involvement of the local authorities is necessary, for identifying and promoting the most efficient RES using projects

  19. A Hybrid RES Distributed Generation System for Autonomous Islands: A DER-CAM and Storage-Based Economic and Optimal Dispatch Analysis

    DEFF Research Database (Denmark)

    Michalitsakos, Panagiotis; Mihet-Popa, Lucian; Xydis, George

    2017-01-01

    -CAM (Distributed Energy Resources Customer Adoption Model) decision support tool was used for the multi-objective analysis conducted, which proposes a set of optimal solutions defining the appropriate Distributed Generation (DG) technologies, the capacities of storage and other technologies and the optimal......The possibility of replacing the existing autonomous thermal power plants by Distributed Energy Resources (DER) based on renewable energy sources (RES), along with the appropriate energy storage technologies in order to deal with the major problems that autonomous islands usually face...... was investigated. A case study of a small Greek island, which is confronted by various energy and water shortages, was studied for assessing the feasibility of DER deployment. The main objectives investigated were cost minimization, CO2 emissions minimization and DER reliability maximization. The DER...

  20. The impacts of renewable energy policies on renewable energy sources for electricity generating capacity

    Science.gov (United States)

    Koo, Bryan Bonsuk

    Electricity generation from non-hydro renewable sources has increased rapidly in the last decade. For example, Renewable Energy Sources for Electricity (RES-E) generating capacity in the U.S. almost doubled for the last three year from 2009 to 2012. Multiple papers point out that RES-E policies implemented by state governments play a crucial role in increasing RES-E generation or capacity. This study examines the effects of state RES-E policies on state RES-E generating capacity, using a fixed effects model. The research employs panel data from the 50 states and the District of Columbia, for the period 1990 to 2011, and uses a two-stage approach to control endogeneity embedded in the policies adopted by state governments, and a Prais-Winsten estimator to fix any autocorrelation in the panel data. The analysis finds that Renewable Portfolio Standards (RPS) and Net-metering are significantly and positively associated with RES-E generating capacity, but neither Public Benefit Funds nor the Mandatory Green Power Option has a statistically significant relation to RES-E generating capacity. Results of the two-stage model are quite different from models which do not employ predicted policy variables. Analysis using non-predicted variables finds that RPS and Net-metering policy are statistically insignificant and negatively associated with RES-E generating capacity. On the other hand, Green Energy Purchasing policy is insignificant in the two-stage model, but significant in the model without predicted values.

  1. Land disposal potential of tobacco processing residues Potencial de uso agrícola de dois resíduos de agroindústria fumageira

    Directory of Open Access Journals (Sweden)

    Marino José Tedesco

    2011-02-01

    Full Text Available Brazil is one of the leaders in the production and trading of tobacco leaves in the global market, which results in a large amount of residues that would be recycled and used as soil fertilizers in agriculture. This research aimed to study the land disposal potential and agricultural use of tobacco processing residues (TPRs, their mineralization and the nutrient supply to the plants. The study was carried out in an open area using pots with 32dm³ of a sandy soil (Paleudult, provided with water drainage collectors and tilled with three corn plants each. Eighteen treatments were tested with mineral fertilization, poultry manure (PM, earthworm compost (EC and increasing rates (0, 7.5, 15, 30 e 60t ha-1 of TPR D (dust and TPR S (stem fibers.Treatments with TPRs (15t ha-1 plus mineral supplementation two by two (NP, NK and PK were also tested, with four replications each. The experiment started in 01/15/2004 and conducted until 03/16/2004, when corn plants were harvested. The response curves showed that the residues application rates between 15 and 20t ha-1 are most adequate for the studied soil. The results indicated that both TPRs may be important sources of biomass and potash and have potential to be recycled in the soil, supplying part of the macronutrients required for proper plant growth.O Brasil é um dos maiores produtores e exportadores mundiais de tabaco em folha, resultando em grandes quantidaes de resíduos que poderiam ser utilizados como fertilizantes na agricultura. O objetivo deste trabalho foi avaliar o potencial de reciclagem agrícola de dois resíduos de agroindústria fumageira (RAF's, sua mineralização no solo e liberação de nutrientes às plantas. O experimento foi conduzido a céu aberto utilizando como unidades experimentais vasos com capacidade de 32 litros de solo, adaptados com tubo coletor de lixiviado e um argissolo (PVAd, cultivado com três plantas de milho. Foram feitos 18 tratamentos com adubo mineral, cama

  2. Coherent Control of Nanoscale Ballistic Currents in Transition Metal Dichalcogenide ReS2.

    Science.gov (United States)

    Cui, Qiannan; Zhao, Hui

    2015-04-28

    Transition metal dichalcogenides are predicted to outperform traditional semiconductors in ballistic devices with nanoscale channel lengths. So far, experimental studies on charge transport in transition metal dichalcogenides are limited to the diffusive regime. Here we show, using ReS2 as an example, all-optical injection, detection, and coherent control of ballistic currents. By utilizing quantum interference between one-photon and two-photon interband transition pathways, ballistic currents are injected in ReS2 thin film samples by a pair of femtosecond laser pulses. We find that the current decays on an ultrafast time scale, resulting in an electron transport of only a fraction of one nanometer. Following the relaxation of the initially injected momentum, backward motion of the electrons for about 1 ps is observed, driven by the Coulomb force from the oppositely moved holes. We also show that the injected current can be controlled by the phase of the laser pulses. These results demonstrate a new platform to study ballistic transport of nonequilibrium carriers in transition metal dichalcogenides.

  3. Anomalous Polarized Raman Scattering and Large Circular Intensity Differential in Layered Triclinic ReS2.

    Science.gov (United States)

    Zhang, Shishu; Mao, Nannan; Zhang, Na; Wu, Juanxia; Tong, Lianming; Zhang, Jin

    2017-10-24

    The Raman tensor of a crystal is the derivative of its polarizability tensor and is dependent on the symmetries of the crystal and the Raman-active vibrational mode. The intensity of a particular mode is determined by the Raman selection rule, which involves the Raman tensor and the polarization configurations. For anisotropic two-dimensional (2D) layered crystals, polarized Raman scattering has been used to reveal the crystalline orientations. However, due to its complicated Raman tensors and optical birefringence, the polarized Raman scattering of triclinic 2D crystals has not been well studied yet. Herein, we report the anomalous polarized Raman scattering of 2D layered triclinic rhenium disulfide (ReS 2 ) and show a large circular intensity differential (CID) of Raman scattering in ReS 2 of different thicknesses. The origin of CID and the anomalous behavior in polarized Raman scattering were attributed to the appearance of nonzero off-diagonal Raman tensor elements and the phase factor owing to optical birefringence. This can provide a method to identify the vertical orientation of triclinic layered materials. These findings may help to further understand the Raman scattering process in 2D materials of low symmetry and may indicate important applications in chiral recognition by using 2D materials.

  4. Predicting Power Output of Upper Body using the OMNI-RES Scale

    Directory of Open Access Journals (Sweden)

    Bautista Iker J.

    2014-12-01

    Full Text Available The main aim of this study was to determine the optimal training zone for maximum power output. This was to be achieved through estimating mean bar velocity of the concentric phase of a bench press using a prediction equation. The values for the prediction equation would be obtained using OMNI-RES scale values of different loads of the bench press exercise. Sixty males ( voluntarily participated in the study and were tested using an incremental protocol on a Smith machine to determine one repetition maximum (1RM in the bench press exercise. A linear regression analysis produced a strong correlation (r = -0.94 between rating of perceived exertion (RPE and mean bar velocity (Velmean. The Pearson correlation analysis between real power output (PotReal and estimated power (PotEst showed a strong correlation coefficient of r = 0.77, significant at a level of p = 0.01. Therefore, the OMNI-RES scale can be used to predict Velmean in the bench press exercise to control the intensity of the exercise. The positive relationship between PotReal and PotEst allowed for the identification of a maximum power-training zone.

  5. Predicting Power Output of Upper Body using the OMNI-RES Scale.

    Science.gov (United States)

    Bautista, Iker J; Chirosa, Ignacio J; Tamayo, Ignacio Martín; González, Andrés; Robinson, Joseph E; Chirosa, Luis J; Robertson, Robert J

    2014-12-09

    The main aim of this study was to determine the optimal training zone for maximum power output. This was to be achieved through estimating mean bar velocity of the concentric phase of a bench press using a prediction equation. The values for the prediction equation would be obtained using OMNI-RES scale values of different loads of the bench press exercise. Sixty males (age 23.61 2.81 year; body height 176.29 6.73 cm; body mass 73.28 4.75 kg) voluntarily participated in the study and were tested using an incremental protocol on a Smith machine to determine one repetition maximum (1RM) in the bench press exercise. A linear regression analysis produced a strong correlation (r = -0.94) between rating of perceived exertion (RPE) and mean bar velocity (Velmean). The Pearson correlation analysis between real power output (PotReal) and estimated power (PotEst) showed a strong correlation coefficient of r = 0.77, significant at a level of p = 0.01. Therefore, the OMNI-RES scale can be used to predict Velmean in the bench press exercise to control the intensity of the exercise. The positive relationship between PotReal and PotEst allowed for the identification of a maximum power-training zone.

  6. The res judicata rule in jurisdictional decisions of the international Court of justice

    Directory of Open Access Journals (Sweden)

    Kreća Milenko

    2014-01-01

    Full Text Available The author discusses the effects of the res judicata rule as regards jurisdictional decisions of the International Court of Justice. He finds that there exists a special position of a judgment on preliminary objection in respect to both aspects of the res judicata rule - its binding force and finality. A perception of distinct relativity of a jurisdictional decision of the Court, expressing its interlocatory character pervades, in his opinion, the body of law regulating the Court's activity. Preliminary objections as such do not exhaust objections to the jurisdiction of the Court, as evidenced by non-preliminary objections to the jurisdiction of the Court giving rise to the application of the principle compétence de la compétence understood in the narrow sense. With regard to the binding force of a judgment on preliminary objections, it does not create legal obligations stricto sensu. The author finds that the relative character of jurisdictional decisions of the Court as compared with a judgment on the merits is justified on a number of grounds.

  7. Electric personnel carrier introduced : RES Equipment Sales spearheads development of electric underground vehicle

    International Nuclear Information System (INIS)

    Tollinsky, N.

    2010-01-01

    RES Equipment Sales of Dryden, Ontario is leading the development of a battery-powered personnel utility vehicle for underground mining applications. Among the advantages of the battery-powered personnel carrier are quietness of the carrier and zero emissions, which eliminates particulates from diesel engines and reduces the need for ventilation. This article discussed the design and building of the vehicle. It was designed to accommodate up to 3 battery packs, depending on the frequency of use. Swapping batteries takes between 2 or 3 minutes. Spent batteries must be plugged in for 6 hours and rest for another 6 to 8 hours before being ready for service. The vehicle accommodates 2 or 3 people and travels at speeds of 6 to 8 miles per hour. This article also provided background information on RES Equipment Sales. The company remanufactures underground mining equipment, including load-haul-dump machines, jumbos, haul trucks and utility vehicles. In addition, the company sells and services new equipment, including Oldenburg Cannon jumbos, scalers and utility vehicles, as well as Canun International pneumatic rock drills and NPK rock breakers. 1 ref., 1 fig.

  8. Resíduos da construção civil em Salvador: os caminhos para uma gestão sustentável Construction waste in Salvador: ways to a sustainable management

    Directory of Open Access Journals (Sweden)

    Gardênia Oliveira David de Azevedo

    2006-03-01

    Full Text Available O artigo discute o impacto ambiental provocado pela geração crescente de resíduos da construção civil e sua disposição inadequada, analisando a legislação sobre o tema e as possibilidades de sua minimização na cidade do Salvador. Como contribuição, são sugeridas medidas para viabilizar a prevenção da geração de resíduos e é proposto um modelo simplificado de fluxo dos resíduos da construção civil em Salvador, para estimular a redução do desperdício nas obras e, conseqüentemente, menor custo na gestão da cidade e menor impacto ambiental. A partir dessa proposta se obteria uma redução da geração dos RCC de 30%, um desvio do aterro de inertes de 37,3% e, ainda, permaneceria seguindo, diretamente, para o aterro 32,7% dos resíduos totais, não absorvidos na reciclagem ou reutilização.This paper discusses the environmental impacts caused by construction waste generation and its inadequate disposal, analyzing the regulation related to this subject and possibilities for its minimization in the city of Salvador. As a contribution measures are suggested to make viable waste construction prevention. It is proposed a draft model for construction waste streams that stimulates the reduction of losses of building materials in construction sites and, consequently, reduces costs in urban management as well as environmental impacts. This proposal suggests the possibility of a source generation reduction of 30%, a 37% diversion of materials from landfills and, still, 32.7% of construction waste generation, not absorbed in the recycling or reuse, remain following, directly, for landfill.

  9. Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia.

    Science.gov (United States)

    Arbyn, Marc; Buntinx, Frank; Van Ranst, Marc; Paraskevaidis, Evangelos; Martin-Hirsch, Pierre; Dillner, Joakim

    2004-02-18

    The appropriate management of women with minor cytologic lesions in their cervix is unclear. We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear. Data were extracted from articles published between 1992 and 2002 that contained results of virologic and cytologic testing followed by colposcopically directed biopsy in women with an index smear showing atypical cells of undetermined significance (ASCUS). Fifteen studies were identified in which HPV triage and the histologic outcome (presence or absence of a cervical intraepithelial neoplasia of grade II or worse [CIN2+]) was documented. Nine, seven, and two studies also documented the accuracy of repeat cytology when the cutoff for abnormal cytology was set at a threshold of ASCUS or worse, low-grade squamous intraepithelial lesion (LSIL) or worse, or high-grade squamous intraepithelial lesion (HSIL) or worse, respectively. Random-effects models were used for pooling of accuracy parameters in case of interstudy heterogeneity. Differences in accuracy were assessed by pooling the ratio of the sensitivity (or specificity) of HPV testing to that of repeat cytology. The sensitivity and specificity were 84.4% (95% confidence interval [CI] = 77.6% to 91.1%) and 72.9% (95% CI = 62.5% to 83.3%), respectively, for HPV testing overall and 94.8% (95% CI = 92.7% to 96.9%) and 67.3% (95% CI = 58.2% to 76.4%), respectively, for HPV testing in the eight studies that used the Hybrid Capture II assay. Sensitivity and specificity of repeat cytology at a threshold for abnormal cytology of ASCUS or worse was 81.8% (95% CI = 73.5% to 84.3%) and 57.6% (95% CI = 49.5% to 65.7%), respectively. Repeat cytology that used higher cytologic thresholds yielded substantially lower sensitivity but higher specificity than triage with the Hybrid Capture II assay. The ratio of the sensitivity of the Hybrid Capture II

  10. Avaliação do gerenciamento dos resíduos de medicamentos e demais resíduos de serviços de saúde na Região Serrana de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Juliana Aparecida Souza Amarante

    2016-10-01

    Full Text Available RESUMO A gestão de resíduos dos serviços de saúde (RSS constitui um grande desafio para o poder público, pois, apesar do avanço nos aspectos legislativos, ainda há grandes deficiências, especialmente relacionadas aos resíduos de medicamentos descartados inadequadamente. Este estudo teve como objetivo caracterizar o processo de descarte de drogas e resíduos dos serviços de saúde humana e veterinária em uma cidade de médio porte da Região Serrana de Santa Catarina. Foram realizadas visitas às unidades participantes, selecionadas por critérios de conveniência, contemplando unidades de saúde municipais, pet shops , clínicas veterinárias, hospital de atendimento humano, hospital de atendimento veterinário e empresas coletoras, totalizando 15 unidades participantes. A coleta de dados ocorreu de março a maio de 2014, com aplicação de questionários e roteiro de observação de campo. Os resultados evidenciaram deficiências no gerenciamento dos resíduos de medicamentos, assim como dos demais resíduos, nas etapas de segregação e armazenamento em instituições de atendimento humano e veterinário, com poucas exceções. As maiores dificuldades foram observadas nos estabelecimentos de atendimento veterinário, especialmente quanto à segregação e ao armazenamento dos resíduos contaminados, à falta de cuidado com material perfurocortante e às normas de biossegurança. A inexistência do Plano de Gerenciamento de Resíduos de Serviços de Saúde nas unidades de saúde e no hospital veterinário, assim como a falta de capacitações aos profissionais, a dissimilaridade no descarte de medicamentos entre os estabelecimentos e a falta de fiscalização por parte dos órgãos competentes foram os principais responsáveis pelo atual cenário de descarte inadequado dos resíduos na região.

  11. Les objectifs et les critères de sélection. Les aptitudes bouchères : croissance, efficacité alimentaire et qualité de la carcasse

    OpenAIRE

    SELLIER, Pierre; BOUIX, J.; Renand, Gilles; MOLENAT, M.

    1992-01-01

    Les programmes de sélection sur les aptitudes bouchères ont un double objectif : l’abaissement du coût de production et l’amélioration de la qualité du produit. Cet article rappelle un certain nombre de données de base sur les aptitudes bouchères : courbe de croissance, évolution de la composition chimique et tissulaire chez l’animal en croissance (notion d’allométrie), énergétique de la croissance (relation entre efficacité alimentaire et croissance musculaire), développement des tissus musc...

  12. El aprendizaje basado en problemas: De herejía artificial a res popularis Problem based learning: From artificial heresy to res popularis

    Directory of Open Access Journals (Sweden)

    L.A. Branda

    2009-03-01

    Full Text Available La extensa implementación del aprendizaje basado en problemas (ABP en el proceso enseñanza-aprendizaje ha resultado en su transformación de herejía artificial a res popularis con la consecuente proliferación de publicaciones, libros y congresos sobre el tema. A menudo, esta avalancha de información, ha creado una confusión en la comprensión de qué es el ABP como estrategia de aprendizaje. Este artículo presenta al lector una definición de lo que se consideró que era el ABP y su extensión, además de incluir la resolución de problemas. Se indica la importancia de los objetivos de aprendizaje (resultados del aprendizaje y se presentan algunos pasos que se deben seguir en la preparación de situaciones/escenarios/problemas/casos. De forma general, se describen la evaluación de los estudiantes fundamentalmente formativa, basada en las observaciones hechas en las sesiones de tutoría, y la evaluación de carácter sumativo. La descripción de las etapas más comunes en el ABP tiene el propósito de indicar lo que los estudiantes pueden hacer y no que deben hacer. Si se consideran las limitaciones de recursos que tienen la mayoría de las instituciones que desean implementar el ABP, se describe la aplicación de esta estrategia en grupos grandes. Se discute el rol del tutor facilitador y se indican las características de sus intervenciones en un continuo que va desde jerárquica a facilitadora de la autonomía del estudiante en su aprendizaje. Este artículo finaliza con una reflexión sobre el aprendizaje autodirigido y su relación con el aprendizaje autorregulado.The vast use of problem based learning (PBL in the teaching-learning process has resulted in its transformation from an artificial heresy to a res popularis with the subsequent proliferation of publications, books and congresses on the subject. This deluge of information, very often, has created confusion on the comprehension of what PBL is as learning strategy. This

  13. 100% RES communities. Steps towards 100% renewable energy at local level in Europe. Motivations, approaches, examples

    International Nuclear Information System (INIS)

    Regnier, Yannick; Pidana, Paulina; Hanisch, Angela; Priesner, Georg C.; Mc Kinney, Simon; Buschmann, Pia; Csanaky, Lilla; Praillet, Frederic; Zanchini, Edoardo; Lefevre, Christelle; ); Marincek, Gorazd; Meiffren, Isabelle; Toplice, Liliana

    2015-01-01

    Enhanced in 2014, the energy and climate goals for 2030 of the European Union require the mobilization of everyone, everywhere. In a dynamic set to intensify rural territories, as well as cities, the communities have a major role to play. As the principal trustees of renewable resource deposits, they are the vanguard of the energy transition. Their strengths? Wind and water in abundance (very often), the sun of course, biomass - agricultural, forest, woodland, domestic, food processing - geothermal energy. With the desire to make this renewable capital live, it made some decide to take or regain control of the energy issue, reduce their energy bills and those of their inhabitants. Attracted by the opportunity to revitalize local economies and rural communes (alone or in groups) they are more likely to want to become 100% RES. But how to move from intention to action when faced with the lack of knowledge, or means, or when you feel too small to act? It is to assist you in developing your energy policy that this guide was written. Pragmatic, practical, it brings together the return on experience from partners and communities involved in 100% RES Communities project. For three years, elected representatives from rural areas, some experienced and some less, together with experts from 10 countries in Europe, have sought the best organizational, technical and financial means to reduce consumption and produce renewable energy. If because of the administrative, cultural, economic differences within the Union, all the territories do not enjoy the same facilities, the 100% RES Communities project has defined pragmatic methods, practices and tools which will make your work easier. You will find in this guide the key steps in defining your strategy and building your action plan. This is a feasible action plan to be shared and implemented with the stakeholders. A final note: because it is within networks that we discover new solutions, which can replenish the practices and

  14. Effective RES blood flow changes in children with homozygous β-thalassemia in relation to blood transfusion

    International Nuclear Information System (INIS)

    Karpathios, T.; Dimitriou, P.; Giamouris, J.; Nicolaidou, P.; Antipas, S.E.; Matsaniotis, N.

    1983-01-01

    Denatured radioiodinated human serum albumin (DHA) clearance studies at a dose of 1 mg/kg body wt., were carried out in 16 thalassemic children, prior to and 7-10 days following blood transfusion, to investigate changes of the effective RES blood flow which might accompany the posttransfusion spleen size diminution. A statistically significant increase (P<0.001) of the DHA plasma clearance rate was observed 7-10 days following blood transfusion denoting an increase of the blood flow to the effective RES while at the same time the spleen diminished in size. It is suggested that changes in the effective RES blood flow in these patients are directly related to changes in the intrasplenic circulatory capacity. (orig.)

  15. CoRes utilization for building PCK in pre-service teacher education on the digestive system topic

    Science.gov (United States)

    Nugraha, Ikmanda

    2017-05-01

    Knowledge of teachers in learning activities in the classroom has a close relationship with how well and how much students learn. Recently, a promising development in teacher education has appeared that centers on the academic construct of pedagogical content knowledge (PCK). This study was an exploratory study into a science teacher education program that seeks to build the foundations on which pre-service teachers can begin to build their pedagogical content knowledge (PCK). The program involved the use of Content Representations (CoRes), which was initially applied as component of a strategy for exploring and gaining insights into the PCK of in-service science teachers. This study involved the researcher and 20 students (third year) in a pre-service teacher education course (School Science I) in science education when the students worked to make content analysis on the digestive system topic. During the course, the students make their own CoRes through a workshop for digestive system topic individually, in pairs and whole class discussion. Data were recorded from students' CoRes, student reflective journals, interviews, and field notes recorded in the researcher's reflective journal. Pre-service teachers' comments from interviews and reflective journals were coded in relation to references about: (1) the effectiveness of variety strategies in building the knowledge bases required to design a CoRes and (2) their awareness and/or development of tentative components of future PCK for a digestive system topic as a result of CoRes construction. Observational data were examined for indications of increasing independence and competency on the part of student teachers when locating appropriate information for designing their CoRes. From this study, it is hoped that the pre-service science teachers are able to build knowledge and then transform it into a form of PCK for digestive system topic for their first classroom planning and teaching to teach digestive system

  16. [HPV-Hr detection by home self sampling in women not compliant with pap test for cervical cancer screening. Results of a pilot programme in Bouches-du-Rhône].

    Science.gov (United States)

    Piana, Lucien; Leandri, François-Xavier; Le Retraite, Laurence; Heid, Patrice; Tamalet, Catherine; Sancho-Garnier, Hélène

    2011-07-01

    The non-participation to cervical screening is the major determinant in the risk of mortality due to cervical cancer. In France, around 40% of women do not participate to regular screening. The cultural or economic barriers for performing screening by Pap test are numerous; one of the most frequent is the refusal of gynaecological examination. A persistent HPV(HR) infection is a necessary factor for developing cervical cancer. The HPV(HR) testing has a high sensibility to detect high grade cervical intra-epithelial neoplasia (CIN 2-3) and a satisfactory specificity after 30-35 years old. The principal objective of this study was to compare the participation rates in women 35-69 years old who did not perform a Pap test after a first individual invitation, either when an HPV(HR) auto-test was offered to be performed at home or a second invitation to Pap test was sent. We also evaluated the quality of the two tests, the positive results obtained by age groups and the following histological type of lesions diagnosed in the women with positive results. The study included 9,334 women, 35-69 years old, who did not realized a Pap-test during the 2 previous years and who did not respond at a first individual invitation. These non-responders were randomized into two groups: one group (n=4,934) received a second individual invitation and the other (n=4,400) an offer of receiving and performing an HPV auto-test at home. In women 35-69 years the participation to the second invitation to Pap test was significantly lower (7.2%) than the participation to auto-test (26.4%) with Plaw rate is a consequence of an inversion of the ratio HPV 16 versus other types in women 60 years old and over. In this group, the follow-up of 36 women diagnosed five cases of CIN1, one of CIN2 and four of CIN3; 22 patients are lost of follow up at 6 months. Globally, in the studied population, an individual recall for pap test allowed to diagnose and treat 3 high grade lesions (7‰) and the dispatching

  17. Nasal bi-level positive airway pressure (BiPAP) versus nasal continuous positive airway pressure (CPAP) in preterm infants ≤32 weeks: A retrospective cohort study.

    Science.gov (United States)

    Rong, Zhi-Hui; Li, Wen-Bin; Liu, Wei; Cai, Bao-Huan; Wang, Jing; Yang, Min; Li, Wei; Chang, Li-Wen

    2016-05-01

    To investigate whether Bi-level positive airway pressure (BiPAP), compared with nasal continuous positive airway pressure (CPAP), is a more effective therapeutic strategy in preterm infants ≤32 weeks. All inborn infants between 26(+1) and 32(+6) weeks' gestation, admitted to the neonatal intensive care unit (NICU ) of Tongji Medical Hospital between 1 January, 2010 and 31 December, 2011 (the 2010-2011 cohort or CPAP cohort) and between 1 January, 2012 and 31 December, 2013 (the 2012-2013 cohort or BiPAP cohort), were retrospectively identified. The primary outcome was intubation in infants CPAP were subsequently intubated (P CPAP, reduced the need for intubation within the first 72 h of age. © 2016 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

  18. Studying young people’ views on deployment of renewable energy sources in Iran through the lenses of Social Cognitive Theory

    Directory of Open Access Journals (Sweden)

    Nadejda Komendantova

    2018-03-01

    Full Text Available Renewable energy sources (RES have potentials to address goals of climate change mitigation at the global level. Iran has abundant RES potentials and investment into renewable energy sources can contribute to its socio-economic development and to diversification of its energy mix. Economic and technical capacities but also human factors, such as stakeholders’ views, public and social acceptance, as well as willingness to use RES, willingness to pay for their deployment and to participate in decision-making processes on energy transition, are crucial factors for deployment of RES at scale. These human factors impact development and implementation of energy transition at the national and local governance levels. Deployment of new technology and energy transition can lead to conflicting views, believes and risks perceptions among involved stakeholders but also among people affected by deployment of new technology infrastructure deployment. To be sustainable and acceptable by all social groups, such process should be based on understanding of positions of different stakeholders and development of compromise solutions. It is crucial to understand the views of young people on deployment of RES as young people represent a significant share of population and are future decision makers. Their support and willingness to use RES will be a significant driver for RES deployment in short and medium term. Based on socio cognitive theory this paper examines the patters of behavior of young adults in relation to energy use. The results show positive influence of self-rewarding to encourage young adults to participate in energy transition. Another important driver is expectation of social outcome, which involves existing social norms in the community. Trust to the source of information is another important driver and the level of information about RES has an important influence on the willingness to use them.

  19. Influencia de preservantes químicos sobre la vida de anaquel de carne de res molida

    OpenAIRE

    Santos, R.; Beldarraín, T.; Ramos, M.; Chang, L.; Martínez, C.; Bruselas, A.

    2008-01-01

    En este trabajo se emplearon lactato de sodio, metabisulfito de sodio, acetato de sodio y sorbato de potasio para la conservación de picadillo de carne de res. Se elaboró picadillo de res que se mezcló durante 5 a 10 min con los siguientes preservantes químicos: 1000 mg/kg de sorbato de potasio (Variante 2), 2 % de lactato de sodio más 0,3 % de acetato de sodio (Variante 3) y 450 mg/kg de SO2 adicionado como metabisulfito de sodio (Variante 4) y se hizo una variante co...

  20. Regulation of Expression of Uropathogenic Escherichia coli Nonfimbrial Adhesin TosA by PapB Homolog TosR in Conjunction with H-NS and Lrp

    Science.gov (United States)

    Engstrom, Michael D.

    2016-01-01

    Urinary tract infections (UTIs) are a major burden to human health. The overwhelming majority of UTIs are caused by uropathogenic Escherichia coli (UPEC) strains. Unlike some pathogens, UPEC strains do not have a fixed core set of virulence and fitness factors but do have a variety of adhesins and regulatory pathways. One such UPEC adhesin is the nonfimbrial adhesin TosA, which mediates adherence to the epithelium of the upper urinary tract. The tos operon is AT rich, resides on pathogenicity island aspV, and is not expressed under laboratory conditions. Because of this, we hypothesized that tosA expression is silenced by H-NS. Lrp, based on its prominent function in the regulation of other adhesins, is also hypothesized to contribute to tos operon regulation. Using a variety of in vitro techniques, we mapped both the tos operon promoter and TosR binding sites. We have now identified TosR as a dual regulator of the tos operon, which could control the tos operon in association with H-NS and Lrp. H-NS is a negative regulator of the tos operon, and Lrp positively regulates the tos operon. Exogenous leucine also inhibits Lrp-mediated tos operon positive regulation. In addition, TosR binds to the pap operon, which encodes another important UPEC adhesin, P fimbria. Induction of TosR synthesis reduces production of P fimbria. These studies advance our knowledge of regulation of adhesin expression associated with uropathogen colonization of a host. PMID:26755158

  1. Compartilhar tarefas? Papéis e funções de pai e mãe na família contemporânea

    Directory of Open Access Journals (Sweden)

    Adriana Wagner

    Full Text Available Este estudo apresenta uma análise do exercício e da divisão de papéis e funções desempenhados por progenitores na criação e educação de seus filhos em idade escolar. Utilizou-se uma amostra de 100 famílias de nível sócio-econômico médio residentes na cidade de Porto Alegre. Foi utilizado um questionário elaborado pelo grupo de pesquisa Dinâmica das Relações Familiares. Os resultados obtidos demostraram que, de forma geral, existe um bom nível de concordância entre as respostas de pais e mães (40% no que se refere a divisão de tarefas na criação dos filhos. Além disso, a análise de Clusters permitiu identificar dois grupos quanto ao desempenho das principais tarefas realizadas na família em relação à educação dos filhos. O Grupo I (49% caracterizou-se por ser a mãe a principal responsável, enquanto o Grupo II (51% caracterizou-se por haver uma divisão igualitária das tarefas entre o pai e a mãe.

  2. A negociação intersubjetiva de significados em Jogos de Interpretação de Papéis

    Directory of Open Access Journals (Sweden)

    Danilo Silva Guimarães

    Full Text Available Este artigo focaliza o processo de negociação intersubjetiva de significados por meio da análise microgenética de sessões de Jogos de Interpretação de Papéis (Role-Playing Games. Partiu-se da suposição de que a análise de interações eu - outro durante o jogo poderia evidenciar aspectos relevantes para a compreensão das relações entre intersubjetividade e alteridade em contextos interpessoais. Os resultados da análise microgenética dos diálogos entre os jogadores evidenciaram a participação de processos psicológicos relevantes para o desenvolvimento humano, em que momentos de tensão e inquietação, característicos das relações de alteridade, alternavam-se com momentos de convergência e compartilhamento sobre os temas da conversa e sobre as posições relativas dos interlocutores.

  3. Resúmenes de trabajos clínicos, VI Congreso AEXMUN

    Directory of Open Access Journals (Sweden)

    Carlos E. Peña

    1993-07-01

    Full Text Available Resúmentes de los siguientes trabajos: Criterios de muerte cerebral ; Simposio sobre enfermedades del músculo estriado. Avances recientes en enfermedadesmusculares ; Selección y estudio del candidato atrasplante cardíaco ; Histopatología de la polimiositis ; Estructura molecular y mecanismo de acciónde los receptores de hormonas esteroides ; Histopatología de las distrofias musculares ; Tiroideopatías en la vejez; Función tiroidea en pacientes eutiroideos con enfermedad no tiroidea "Síndrome del paciente eutiroideo" ; Hipertensión arterial y endotelio ; Hipertensión renovascular

  4. Comparison of auctions and alternative policy options for RES-E support

    DEFF Research Database (Denmark)

    Kitzing, Lena; Islam, Marco; Fitch-Roy, Oscar

    2016-01-01

    benefits of RES, there may be valid reasons for policy makers not to employ auctions, since under particular circumstances it may be desirable not to control quantities but the price. As such, they raise the question whether pure support cost minimisation should be the only goal when implementing......This report concludes the work carried out in the course of Task 6.2 of the AURES project. It is its aim to compare auctions with alternative policy instruments and in particular, to examine under which circumstances auctions may be superior and inferior to achieve intended policy targets....... For that purpose, we identify a number of potential drivers that might affect an instrument’s effectiveness, its efficiency and further success criteria. Among this list of relevant drivers, the basis for our analysis is the factor risk, where our core focus is on risk for policy makers. Assuming a world...

  5. Développement folliculaire ovarien et ovulation chez les mammifères

    OpenAIRE

    Monniaux , Danielle; Caraty , Alain; Clement , Frederique; Dalbiès-Tran , Rozenn; Dupont , J.; Fabre , Stéphane; Gérard , N.; Mermillod , Pascal; Monget , Philippe; Uzbekova , Svetlana

    2009-01-01

    Cette revue présente l’état des connaissances sur la folliculogenèse et l’ovulation chez les mammifères. La folliculogenèse basale est une phase de croissance folliculaire lente, au cours de laquelle l’ovocyte acquiert la compétence méiotique. La folliculogenèse terminale est une phase de développement rapide, au cours de laquelle le follicule ovulatoire est sélectionné et termine sa maturation, tandis que l’ovocyte acquiert la compétence au développement. La revue décrit les différents chang...

  6. Les premières années de The Himalayan Journal (1929-1940

    Directory of Open Access Journals (Sweden)

    Michel Raspaud

    2001-05-01

    Full Text Available IntroductionLa création de The Himalayan Club, sur le territoire de l’Empire des Indes à la fin de l’année 1927, s’accompagne presque aussitôt de la publication de The Himalayan Journal, en février 1929, soit mois de dix-huit mois après la création officielle de l’institution. L’objet du présent texte concerne donc la vie de The Himalayan Club lors de ses premières années d’existence, depuis la date de sa création jusqu’au début de la seconde guerre mondiale. Cependant, l’intérêt se focaliser...

  7. An RES-Based Model for Risk Assessment and Prediction of Backbreak in Bench Blasting

    Science.gov (United States)

    Faramarzi, F.; Ebrahimi Farsangi, M. A.; Mansouri, H.

    2013-07-01

    Most blasting operations are associated with various forms of energy loss, emerging as environmental side effects of rock blasting, such as flyrock, vibration, airblast, and backbreak. Backbreak is an adverse phenomenon in rock blasting operations, which imposes risk and increases operation expenses because of safety reduction due to the instability of walls, poor fragmentation, and uneven burden in subsequent blasts. In this paper, based on the basic concepts of a rock engineering systems (RES) approach, a new model for the prediction of backbreak and the risk associated with a blast is presented. The newly suggested model involves 16 effective parameters on backbreak due to blasting, while retaining simplicity as well. The data for 30 blasts, carried out at Sungun copper mine, western Iran, were used to predict backbreak and the level of risk corresponding to each blast by the RES-based model. The results obtained were compared with the backbreak measured for each blast, which showed that the level of risk achieved is in consistence with the backbreak measured. The maximum level of risk [vulnerability index (VI) = 60] was associated with blast No. 2, for which the corresponding average backbreak was the highest achieved (9.25 m). Also, for blasts with levels of risk under 40, the minimum average backbreaks (<4 m) were observed. Furthermore, to evaluate the model performance for backbreak prediction, the coefficient of correlation ( R 2) and root mean square error (RMSE) of the model were calculated ( R 2 = 0.8; RMSE = 1.07), indicating the good performance of the model.

  8. A novel protein-protein interaction in the RES (REtention and Splicing) complex.

    Science.gov (United States)

    Tripsianes, Konstantinos; Friberg, Anders; Barrandon, Charlotte; Brooks, Mark; van Tilbeurgh, Herman; Seraphin, Bertrand; Sattler, Michael

    2014-10-10

    The retention and splicing (RES) complex is a conserved spliceosome-associated module that was shown to enhance splicing of a subset of transcripts and promote the nuclear retention of unspliced pre-mRNAs in yeast. The heterotrimeric RES complex is organized around the Snu17p protein that binds to both the Bud13p and Pml1p subunits. Snu17p exhibits an RRM domain that resembles a U2AF homology motif (UHM) and Bud13p harbors a Trp residue reminiscent of an UHM-ligand motif (ULM). It has therefore been proposed that the interaction between Snu17p and Bud13p resembles canonical UHM-ULM complexes. Here, we have used biochemical and NMR structural analysis to characterize the structure of the yeast Snu17p-Bud13p complex. Unlike known UHMs that sequester the Trp residue of the ULM ligand in a hydrophobic pocket, Snu17p and Bud13p utilize a large interaction surface formed around the two helices of the Snu17p domain. In total 18 residues of the Bud13p ligand wrap around the Snu17p helical surface in an U-turn-like arrangement. The invariant Trp(232) in Bud13p is located in the center of the turn, and contacts surface residues of Snu17p. The structural data are supported by mutational analysis and indicate that Snu17p provides an extended binding surface with Bud13p that is notably distinct from canonical UHM-ULM interactions. Our data highlight structural diversity in RRM-protein interactions, analogous to the one seen for nucleic acid interactions. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. Parâmetros psicométricos das escalas de qualidade dos papéis desempenhados pela mulher: mãe e trabalho pago Psychometric parameters of quality roles scales performed by women: mother and paid work

    Directory of Open Access Journals (Sweden)

    Izabel Cristina Possatti

    2002-01-01

    Full Text Available A necessidade de avaliar a qualidade de papéis desempenhados por mulheres no trabalho pago e no papel de mãe, levaram a construção de escalas que pudessem medi-los. Considerando a falta de medidas adequadas para avaliar estes papéis, a presente pesquisa teve como objetivo estabelecer as propriedades psicométricas em amostras brasileiras das escalas sobre a qualidade de papéis desenvolvidas nos EUA por Baruch e Barnett em 1986. Os dados vieram a partir de uma amostra de 519 mães empregadas que responderam a itens de recompensa e preocupação para cada papel. Foram realizadas análises fatoriais dos eixos principais (PAF para identificar fatores que pudessem ser usados em análises posteriores. Os resultados encontrados asseguram confiáveis parâmetros psicométricos para as escalas, permitindo que as mesmas sejam utilizadas para mensurar a qualidade destes papéis.The necessity of assessing the women's roles quality, such as paid worker and mother roles, led to the construction of scales that could measure them. Considering the lack of adequate measures to assess these roles, the present research aimed to investigate the psychometric properties in Brazilian samples of role quality scales developed in the USA by Baruch and Barnett (1986. The data consisted of 519 employed mothers who answered items about rewards and concerns relating to each role. A factor analysis using principal axis factoring was used to identify factors that could be used in further analyses. The results show reliable psychometric parameters in the assessment of role quality.

  10. An overview of the EU Member States support schemes for the promotion of renewable energy sources

    Energy Technology Data Exchange (ETDEWEB)

    Poullikkas, Andreas; Kourtis, George; Hadjipaschalis, Ioannis [Electricity Authority of Cyprus, P.O. Box 24506, 1399 Nicosia (Cyprus)

    2012-07-01

    In this work, an overview of the European Union (EU) Member States support schemes for the promotion of renewable energy sources (RES) is provided. In particular, the status of the electricity generation capacity as well as the RES mixture in the Member States is described. Moreover, the different support schemes such as, investment support, feed-in tariffs (FiTs), tradable green certificates, and fiscal and financial measures which the Member States have adopted for the promotion of RES technologies are discussed in detail. Some Member States are implementing a single support scheme for the promotion of RES for power generation (RES-E), e.g., seven Member States use FiTs, or implement a hybrid support scheme by combining all or some of the four categories of the RES-E supporting schemes. Although, these support schemes have increased the penetration of the RES-E technologies in the Member States, still there is a long way in order to achieve the 2020 target. The reason for this may be that the way these schemes have been used so far, i.e., either as single support schemes or in combination of FiTs or tradable green certificates with investment support and fiscal and financial measures, has been ineffective. A more effective combination could be a hybrid scheme consisting of FiTs with tradable green certificates measures, as in the case of Italy and United Kingdom, that will increase the RES-E penetration and eliminate the possible technical problems which will arise from this increased penetration and have an effect in the stability of the power system.

  11. Design and simulation of front end power converter for a microgrid with fuel cells and solar power sources

    Science.gov (United States)

    Jeevargi, Chetankumar; Lodhi, Anuj; Sateeshkumar, Allu; Elangovan, D.; Arunkumar, G.

    2017-11-01

    The need for Renewable Energy Sources (RES) is increasing due to increased demand for the supply of power and it is also environment friendly.In the recent few years, the cost of generation of the power from the RES has been decreased. This paper aims to design the front end power converter which is required for integrating the fuel cells and solar power sources to the micro grid. The simulation of the designed front end converter is carried out in the PSIM 9.1.1 software. The results show that the designed front end power converter is sufficient for integrating the micro grid with fuel cells and solar power sources.

  12. A micro-grid operation analysis for cost-effective battery energy storage and RES plants integration

    International Nuclear Information System (INIS)

    Barelli, L.; Bidini, G.; Bonucci, F.

    2016-01-01

    Penetration of renewable energy is strongly slowed by its characteristic intermittency and fluctuating trend and by the inadequacy of electricity networks. These issues can be addressed through the development of new or improved storage technologies with higher performance, availability, durability, safety and lower costs. In the present work, micro-grids characterized by the presence of different subsections including renewable plants coupled with batteries storage solution are investigated through the development of a suitable code. Several design conditions and features, related to RES plant, storage system and users, were considered in order to realize a sensitivity analysis aimed to examine, on a yearly base and with one minute time step, interactions among the different micro-grid subsections and to identify the best solutions from both economic and energy point of views. - Highlights: • Storage systems coupling to RES plants is investigated for micro-grids. • Interactions between RES plants, storage batteries and users are analyzed. • Self-consumption increases with storage installation. • Investment pay-back analysis is performed varying plant configurations. • Pay-back reduction up to 30–40% for new RES/Storage integrated installations.

  13. Toxoplasmosis in a bar-shouldered dove (Geopelia humeralis) from the zoo of Clères, France

    Science.gov (United States)

    Toxoplasmosis causes mortality in several avian species, especially passerine birds. Toxoplasmosis was diagnosed in a bar-shouldered dove (Geopelia humeralis) found dead at the zoo of Clères (France). The bird had necrotizing pneumonia and nephritis with intralesional tachyzoites of Toxoplasma gondi...

  14. Venelastest Res Publica toetajad Ida-Virus võivad uuele parteile selja pöörata / Erik Kalda

    Index Scriptorium Estoniae

    Kalda, Erik, 1969-

    2006-01-01

    Ilmunud ka: Severnoje Poberezhje 6. apr. lk. 3, Narvskaja Nedelja 8. apr. lk. 2. Suur osa Ida-Virumaal elavatest Res Publica liikmetest ning toetajatest ei poolda erakonna ühinemist Isamaaliiduga, sest paljude venelaste meelest on Isamaaliit nende huve eirav partei

  15. Impact of Mézières Rehabilitative Method in Patients with Parkinson’s Disease: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Teresa Paolucci

    2017-01-01

    Full Text Available The aim of this study was to assess the efficacy of Mézières method in improving trunk flexibility of the back muscles and balance in patients with Parkinson’s disease (PD. Materials and Methods. Thirty-six patients were randomized into 2 groups: the Mézières treatment group and the control group (home exercise group. The primary outcome was the improvement in balance per the Berg Balance Scale (BBS and the trunk flexibility of the back for the anterior flexion trunk test. Also, we evaluated pain, gait balance for the Functional Gait Assessment (FGA, disease-related disability for the Modified Parkinson’s Activity Scale and the Unified Parkinson’s Disease Rating Scale (UPDRS, the quality of life, and the functional exercise capacity. All the measures were evaluated at baseline (T0, at the end of the rehabilitative program (T1, and at the 12-week follow-up (T2. Results. In the Mézières group, the BBS (p<.001 and trunk flexion test (p<.001 improved significantly at T1 and remained the same at T2. Between groups, significant changes were reported in FGA (p=.027 and UPDRS Total (p=.007 at T1 and in FGA (p=.03 at T2. Conclusion. The Mézières approach is efficacious in improving the flexibility of the trunk and balance in PD patients.

  16. SANTÉ PUBLIQUE Les troubles de santé font fi des frontières – les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    SANTÉ PUBLIQUE Les troubles de santé font fi des frontières – les connaissances et les solutions devraient elles ... Dangers du tabac et des narguilés pour la santé ... ÉTUDE DE CAS : Nouvelles armes dans la guerre contre le paludisme.

  17. Emissão de metano por decomposição de resíduo florestal inundado

    Directory of Open Access Journals (Sweden)

    Maria M. V. Zanoni

    2015-02-01

    Full Text Available A construção de represas pode aumentar a emissão de gases do efeito estufa (GEE, principalmente metano (CH4 pela decomposição anaeróbica dos resíduos florestais, como galhos, ramos, folhas e miscelânea inundados. Objetivou-se, neste estudo, avaliar a emissão de CH4 após a inundação do solo coberto com resíduos florestais. Unidades experimentais foram construídas com tubos de PVC contendo solo e diferentes combinações de dose (0; 21,2; 42,3 e 64,1 Mg ha-1 e tipo de resíduos (folhas, ramos e miscelânea, galhos e composição original e água de rio. O delineamento experimental foi inteiramente casualizado com arranjo fatorial e três repetições. As taxas de emissão de CH4 foram monitoradas em 19 eventos durante um ano (Fevereiro/2012 a Março/2013. Cerca de 75 dias após a incubação do solo com resíduos florestais verificou-se aumento das emissões de CH4, ocorrendo dois picos de emissão, aos 111 e aos 249 dias. A emissão acumulada de CH4 no primeiro ano de alagamento foi de 200 g C m-2 na dose zero, passando a valores próximos a 400 g C m-2 nas doses de 21,2 Mg ha-1 e maiores, não havendo efeito do tipo de resíduo, apenas da dose, como fator isolado.

  18. Dimeric Fe (II, III) complex of quinoneoxime as functional model of PAP enzyme: Mössbauer, magneto-structural and DNA cleavage studies

    Science.gov (United States)

    Salunke-Gawali, Sunita; Ahmed, Khursheed; Varret, François; Linares, Jorge; Zaware, Santosh; Date, Sadgopal; Rane, Sandhya

    2008-07-01

    Purple acid phosphatase, ( PAP), is known to contain dinuclear Fe2 + 2, + 3 site with characteristic Fe + 3 ← Tyr ligand to metal charge transfer in coordination. Phthiocoloxime (3-methyl-2-hydroxy-1,4-naphthoquinone-1-oxime) ligand L, mimics (His/Tyr) ligation with controlled and unique charge transfers resulting in valence tautomeric coordination with mixed valent diiron site in model compound Fe-1: [μ-OH-Fe2 + 2, + 3 ( o-NQCH3ox) ( o-NSQCH3ox)2 (CAT) H2O]. Fe-2: [Fe + 3( o-NQCH3ox) ( p-NQCH3ox)2]2 a molecularly associated dimer of phthiocoloxime synthesized for comparison of charge transfer. 57Fe Mössbauer studies was used to quantitize unusual valences due to ligand in dimeric Fe-1 and Fe-2 complexes which are supported by EPR and SQUID studies. 57Fe Mössbauer spectra for Fe-1 at 300 K indicates the presence of two quadrupole split asymmetric doublets due to the differences in local coordination geometries of [Fe + 3]A and [Fe + 2]B sites. The hyperfine interaction parameters are δ A = 0.152, (Δ E Q)A = 0.598 mm/s with overlapping doublet at δ B = 0.410 and (Δ E Q)B = 0.468 mm/s. Due to molecular association tendency of ligand, dimer Fe-2 possesses 100% Fe + 3(h.s.) hexacoordinated configuration with isomer shift δ = 0.408 mm/s. Slightly distorted octahedral symmetry created by NQCH3ox ligand surrounding Fe + 3(h.s.) state generates small field gradient indicated by quadrupole split Δ E Q = 0.213 mm/s. Decrease of isomer shifts together with variation of quadrupole splits with temperature in Fe-1 dimer compared to Fe-2 is result of charge transfers in [Fe2 + 2, + 3 SQ] complexes. EPR spectrum of Fe-1 shows two strong signals at g 1 = 4.17 and g 2 = 2.01 indicative of S = 3/2 spin state with an intermediate spin of Fe + 3(h.s.) configuration. SQUID data of χ _m^{corr} .T were best fitted by using HDVV spin pair model S = 2, 3/2 resulting in antiferromagnetic exchange ( J = -13.5 cm - 1 with an agreement factor of R = 1.89 × 10 - 5). The lower J

  19. Rapid and sensitive detection of Bartonella bacilliformis in experimentally infected sand flies by loop-mediated isothermal amplification (LAMP of the Pap31 gene.

    Directory of Open Access Journals (Sweden)

    Nasikarn Angkasekwinai

    2014-12-01

    Full Text Available Carrion' disease, caused by Bartonella bacilliformis, remains truly neglected due to its focal geographical nature. A wide spectrum of clinical manifestations, including asymptomatic bacteremia, and lack of a sensitive diagnostic test can potentially lead to a spread of the disease into non-endemic regions where competent sand fly vectors may be present. A reliable test capable of detecting B. bacilliformis is urgently needed. Our objective is to develop a loop-mediated isothermal amplification (LAMP assay targeting the pap31 gene to detect B. bacilliformis.The sensitivity of the LAMP was evaluated in comparison to qPCR using plasmid DNA containing the target gene and genomic DNA in the absence and presence of human or sand fly DNA. The detection limit of LAMP was 1 to 10 copies/µL, depending on the sample metrics. No cross-reaction was observed when testing against a panel of various closely related bacteria. The utility of the LAMP was further compared to qPCR by the examination of 74 Lutzomyia longipalpis sand flies artificially fed on blood spiked with B. bacilliformis and harvested at days (D 1, 3, 5, 7 and 9 post feeding. Only 86% of sand flies at D1 and 63% of flies at D3 were positive by qPCR. LAMP was able to detect B. bacilliformis in all those flies confirmed positive by qPCR. However, none of the flies after D3 were positive by either LAMP or qPCR. In addition to demonstrating the sensitivity of the LAMP assay, these results suggest that B. bacilliformis cannot propagate in artificially fed L. longipalpis.The LAMP assay is as sensitive as qPCR for the detection of B. bacilliformis and could be useful to support diagnosis of patients in low-resource settings and also to identify B. bacilliformis in the sand fly vector.

  20. Forecast of power generation and heat production from renewable energy sources

    Directory of Open Access Journals (Sweden)

    Pydych Tadeusz

    2017-01-01

    Full Text Available The share of renewable energy sources (RES in the end use of energy in the UE will increase from the present level of about 25% to 50 % in 2030 according to the assumptions of the European Commission. In Poland the RES Act was passed in 2015. The act defines mechanisms and instruments for supporting the production of electricity and heat from renewable energy sources. Statistics (2003–2014 of electricity generation and heat production from RES in Poland were used in the research. Because of amendments to regulations connected with promoting RES and the emissions trading system (ETS as well as the uncertainty associated with further directions of the energy and environmental policy, generation of electricity and heat based on the use of RES must be modelled while taking risk into account. A number of dynamic processes incorporating random events may be modelled by stochastic equations using Ito calculus. By applying Euler’s method to solve stochastic differential equations (SDE, it is possible to simulate the development of the use of renewable energy carriers in electricity generation and heat production in the future.