Local control unit for ITER-India gyrotron test facility (IIGTF)

Energy Technology Data Exchange (ETDEWEB)

Rathod, Vipal, E-mail: vipal.rathod@iter-india.org; Shah, Ronak; Mandge, Deepak; Parmar, Rajvi; Rao, S.L.

2016-11-15

Highlights: • A dedicated full scale ITER prototype Local Control Unit for ITER-India Gyrotron test facility. • National Instruments® make PXIe system for real time control & data acquisition and Siemens® PLC for sequence control function. • Hardwired FPGA based fast protection interlock system. • High speed analog fiber optical transmission link using V/F and F/V technique. • Software framework based on LabVIEW™ platform and ITER CODAC Core System. - Abstract: Electron Cyclotron system on ITER, is one of the important RF ancillary systems based on high power Gyrotron RF sources, that is used for plasma heating and current drive applications. To operate a Gyrotron source, various auxiliary systems and services such as Super Conducting Magnet set, High Voltage Power Supplies, Auxiliary Power Supplies, Waveguide components, Cooling water system and a Local Control Unit (LCU) are required. The LCU plays a very crucial role for the safe and reliable operation of Gyrotron system. A dedicated full scale ITER prototype LCU is being developed for testing and commissioning of an ITER like Test Gyrotron at ITER-India Gyrotron Test facility (IIGTF). The main functions of LCU include Sequence Control, Local Interlock Protection and Real Time Data Acquisition. PLC based slow controller is used for implementing the Sequence Control & Slow Interlock functions. Critical Protection Interlocks are required to have a response time of <10 μs and are implemented using custom built hardware and PXIe based fast controller. Also PXIe system is used for implementing Real Time Data Acquisition function that is required to have slow and fast acquisition with online visualization and off line analysis facility. A Signal Conditioning Unit (SCU) is used to interface and faithfully transmit the field signals to the remote control systems. Necessary controller hardware is procured and several pre-prototype developments have been taken up to establish the critical subsystems such as

Local control unit for ITER-India gyrotron test facility (IIGTF)

International Nuclear Information System (INIS)

Rathod, Vipal; Shah, Ronak; Mandge, Deepak; Parmar, Rajvi; Rao, S.L.

2016-01-01

Highlights: • A dedicated full scale ITER prototype Local Control Unit for ITER-India Gyrotron test facility. • National Instruments® make PXIe system for real time control & data acquisition and Siemens® PLC for sequence control function. • Hardwired FPGA based fast protection interlock system. • High speed analog fiber optical transmission link using V/F and F/V technique. • Software framework based on LabVIEW™ platform and ITER CODAC Core System. - Abstract: Electron Cyclotron system on ITER, is one of the important RF ancillary systems based on high power Gyrotron RF sources, that is used for plasma heating and current drive applications. To operate a Gyrotron source, various auxiliary systems and services such as Super Conducting Magnet set, High Voltage Power Supplies, Auxiliary Power Supplies, Waveguide components, Cooling water system and a Local Control Unit (LCU) are required. The LCU plays a very crucial role for the safe and reliable operation of Gyrotron system. A dedicated full scale ITER prototype LCU is being developed for testing and commissioning of an ITER like Test Gyrotron at ITER-India Gyrotron Test facility (IIGTF). The main functions of LCU include Sequence Control, Local Interlock Protection and Real Time Data Acquisition. PLC based slow controller is used for implementing the Sequence Control & Slow Interlock functions. Critical Protection Interlocks are required to have a response time of <10 μs and are implemented using custom built hardware and PXIe based fast controller. Also PXIe system is used for implementing Real Time Data Acquisition function that is required to have slow and fast acquisition with online visualization and off line analysis facility. A Signal Conditioning Unit (SCU) is used to interface and faithfully transmit the field signals to the remote control systems. Necessary controller hardware is procured and several pre-prototype developments have been taken up to establish the critical subsystems such as

Research on megawatt gyrotrons, January 1983-December 1984

International Nuclear Information System (INIS)

Read, M.E.

1984-01-01

During the last several years, NRL has performed research on concepts for high power gyrotrons. The work funded by the Department of Energy has been in support of industrial development of high frequency (60 to 140 GHz) CW gyrotrons, with NRL research being on the origination, development, and testing of advanced concepts. The research performed under this agreement has included experimental work on quasi-optical and complex cavity gyrotrons and theoretical efforts on these concepts as well as whispering gallery gyrotrons

New results in development of MW output power gyrotrons for fusion systems

International Nuclear Information System (INIS)

Litvak, A.G.; Denisov, G.G.; Ilin, V.I.; Kurbatov, V.I.; Myasnikov, V.E.; Soluyanova, E.A.; Tai, E.M.; Usachev, S.V.; Zapevalov, V.E.

2005-01-01

The paper presents the latest achievements of the Russian gyrotron team in development of MW power gyrotrons for fusion installations. During two last years four new gyrotrons were designed and tested: a new version of 170 GHz gyrotron for ITER; multi-frequency (105-140 GHz) gyrotron for Asdex-Up, 84GHz gyrotron for LHD and 82.7 GHz gyrotron for SST-1. All these gyrotrons are equipped with diamond CVD windows and depressed collectors

Efficient Low-Voltage Operation of a CW Gyrotron Oscillator at 233 GHz.

Science.gov (United States)

Hornstein, Melissa K; Bajaj, Vikram S; Griffin, Robert G; Temkin, Richard J

2007-02-01

The gyrotron oscillator is a source of high average power millimeter-wave through terahertz radiation. In this paper, we report low beam power and high-efficiency operation of a tunable gyrotron oscillator at 233 GHz. The low-voltage operating mode provides a path to further miniaturization of the gyrotron through reduction in the size of the electron gun, power supply, collector, and cooling system, which will benefit industrial and scientific applications requiring portability. Detailed studies of low-voltage operation in the TE(2) (,) (3) (,) (1) mode reveal that the mode can be excited with less than 7 W of beam power at 3.5 kV. During CW operation with 3.5-kV beam voltage and 50-mA beam current, the gyrotron generates 12 W of RF power at 233.2 GHz. The EGUN electron optics code describes the low-voltage operation of the electron gun. Using gun-operating parameters derived from EGUN simulations, we show that a linear theory adequately predicts the low experimental starting currents.

The MTX computer control system for the 400 kilowatt 140 Ghz gyrotron

International Nuclear Information System (INIS)

Jackson, M.C.; Ferguson, S.W.; Petersen, D.E.

1992-01-01

This paper reports on a 400 kilowatt, 140 Ghz gyrotron employed on MTX as a source of direct plasma heating and, additionally, as a driver for a free electron laser, which is used for plasma heating. The control system that operates this gyrotron uses a new graphics oriented software system called TACL (Thaumaturgic Automated Control Logic) developed by the Continuous Electron Beam Accelerator Facility (CEBAF) and owned by DOE. This control language does not require a software specialist, but is easily handled by the engineer or technician working on the system. All control logic and custom displays are entered via graphics oriented editors and no actual lines of code need to be written. The graphics displays make the gyrotron operation quite simple and allow individual users to define displays to meet their own needs or develop one for a specific set of tests to be run. The system, additionally, can be used for data logging functions, which have been found quite useful in tracking long term trends in vacion current and calorimetry of gyrotron cooling circuits

An integrated gyrotron controller

Energy Technology Data Exchange (ETDEWEB)

Michel, Georg, E-mail: michel@ipp.mpg.de; Sachtleben, Juergen

2011-10-15

The ECRH system of W7-X is composed of 10 independent gyrotron modules. Each module consists of one gyrotron and its peripherals such as power supplies, cooling plants and distributed PLC systems. The fast real-time control functions such as the timing of the two high voltage supplies, trigger pulses, protection, modulation and communication with the central control of W7-X, is implemented in an integrated controller which is described in this paper. As long-term maintainability and sustainability are important for nuclear fusion experiments, the choice fell on an FPGA-based design which is exclusively based on free (as in 'freedom') software and configuration code. The core of the controller consists of a real-time Java virtual machine (JVM) that provides the TCP-IP connectivity as well as more complicated control functions, and which interacts with the gyrotron-specific hardware. Both the gyrotron-specific hardware and the JVM are implemented on the same FPGA, which is the main component of the controller. All 10 controllers are currently completed and operational. All parameters and functions are accessible via Ethernet. Due to the open, FPGA-based design, most hardware modifications can be made via the network as well. This paper discusses the capabilities of the controllers and their integration into the central W7-X control.

The MTX computer control system for the 400 kilowatt 140 GHz gyrotron

International Nuclear Information System (INIS)

Jackson, M.C.; Ferguson, S.W.; Petersen, D.E.

1991-09-01

A 400 kilowatt, 140 Ghz gyrotron is employed on MTX as a source of direct plasma heating and, additionally, as a driver for a free electron laser, which is used for plasma heating. The control system that operates this gyrotron uses a new graphics oriented software system called TACL (Thaumaturgic Automated Control Logic) developed by the Continuous Electron Beam Accelerator Facility (CEBAF) and owned by DOE. This control language does not require a software specialist, but is easily handled by the engineer or technician working on the system. All control logic and custom displays are entered via graphics oriented editors and no actual lines of code need to be written. The graphics displays make the gyrotron operation quite simple and allow individual users to define displays to meet their own needs or develop one for a specific set of tests to be run. The system, additionally, can be used for logging functions, which have been found quite useful in tracking long term trends in vacion current and calorimetry of gyrotron cooling circuits. The system is composed of one computer (HP 9000 series 300) controlling multiple CAMAC crates located at the various components used in the system. A second series 300 computer is used as a supervisor and is located in the main tokamak control room. This supervisory computer provides remote operation of the gyrotron, and also provides a link to the microwave transport vacuum control (also TACL). The supervisory computer, additionally, is used as a subsystem status summary point for permissives to the gyrotron control system

Chaos in high-power high-frequency gyrotrons

International Nuclear Information System (INIS)

Airila, M.

2004-01-01

Gyrotron interaction is a complex nonlinear dynamical process, which may turn chaotic in certain circumstances. The emergence of chaos renders dynamical systems unpredictable and causes bandwidth broadening of signals. Such effects would jeopardize the prospect of advanced gyrotrons in fusion. Therefore, it is important to be aware of the possibility of chaos in gyrotrons. There are three different chaos scenarios closely related to the development of high-power gyrotrons: First, the onset of chaos in electron trajectories would lead to difficulties in the design and efficient operation of depressed potential collectors, which are used for efficiency enhancement. Second, the radio-frequency signal could turn chaotic, decreasing the output power and the spectral purity of the output signal. As a result, mode conversion, transmission, and absorption efficiencies would be reduced. Third, spatio-temporal chaos in the resonator field structure can set a limit for the use of large-diameter interaction cavities and high-order TE modes (large azimuthal index) allowing higher generated power. In this thesis, the issues above are addressed with numerical modeling. It is found that chaos in electron residual energies is practically absent in the parameter region corresponding to high efficiency. Accordingly, depressed collectors are a feasible solution also in advanced high-power gyrotrons. A new method is presented for straightforward numerical solution of the one-dimensional self-consistent time-dependent gyrotron equations, and the method is generalized to two dimensions. In 1D, a chart of gyrotron oscillations is calculated. It is shown that the regions of stationary oscillations, automodulation, and chaos have a complicated topology in the plane of generalized gyrotron variables. The threshold current for chaotic oscillations exceeds typical operating currents by a factor of ten. However, reflection of the output signal may significantly lower the threshold. 2D

Depressed collectors for millimeter wave gyrotrons

International Nuclear Information System (INIS)

Singh, A.; Granatstein, V.L.

1992-01-01

The main issues relating to design of depressed collectors for millimeter wave gyrotrons are discussed. A flow diagram is presented and the interlinking steps are outlined. Design studies are given for two kinds of gyrotrons on which severe constraints on the maximum radii of the collectors had been imposed; namely, for a cavity type and a quasi-optical gyrotron. A collector efficiency of the order of 70 percent is shown to be feasible for either case using careful tailoring of magnetic field profiles. A code has been developed to assist in doing this. A general approach toward initial placement of collectors has been indicated

Active heater control and regulation for the Varian VGT-8011 gyrotron

International Nuclear Information System (INIS)

Harris, T.E.

1991-10-01

The Varian VGT-8011 gyrotron is currently being used in the new 110 GHz 2 MW ECH system installed on D3-D. This new ECH system augments the 60 GHz system which uses Varian VA-8060 gyrotrons. The new 110 GHz system will be used for ECH experiments on D3-D with a pulse width capability of 10 sec. In order to maintain a constant RF outpower level during long pulse operation, active filament-heater control and regulation is required to maintain a constant cathode current. On past D3-D experiments involving the use of Varian VA-8060 gyrotrons for ECH power, significant gyrotron heater-emission depletion was experienced for pulse widths > 300 msec. This decline in heater-emission directly results in gyrotron-cathode current droop. Since RF power from gyrotrons decreases as cathode current decreases, it is necessary to maintain a constant cathode current level during gyrotron pulses for efficient gyrotron operation. Therefore, it was determined that a filament-heater control system should be developed for the Varian VGT-8011 gyrotron which will include cathode-current feed-back. This paper discusses the mechanisms used to regulate gyrotron filament-heater voltage by using cathode-current feed-back. 1 fig

Application of Fusion Gyrotrons to Enhanced Geothermal Systems (EGS)

Science.gov (United States)

Woskov, P.; Einstein, H.; Oglesby, K.

2013-10-01

The potential size of geothermal energy resources is second only to fusion energy. Advances are needed in drilling technology and heat reservoir formation to realize this potential. Millimeter-wave (MMW) gyrotrons and related technologies developed for fusion energy research could contribute to enabling EGS. Directed MMW energy can be used to advance rock penetration capabilities, borehole casing, and fracking. MMWs are ideally suited because they can penetrate through small particulate extraction plumes, can be efficiently guided long distances in borehole dimensions, and continuous megawatt sources are commercially available. Laboratory experiments with a 10 kW, 28 GHz CPI gyrotron have shown that granite rock can be fractured and melted with power intensities of about 1 kW/cm2 and minute exposure times. Observed melted rock MMW emissivity and estimated thermodynamics suggest that penetrating hot, hard crystalline rock formations may be economic with fusion research developed MMW sources. Supported by USDOE, Office of Energy Efficiency and Renewable Energy and Impact Technologies, LLC.

Analytic theory of the gyrotron

International Nuclear Information System (INIS)

Lentini, P.J.

1989-06-01

An analytic theory is derived for a gyrotron operating in the linear gain regime. The gyrotron is a coherent source of microwave and millimeter wave radiation based on an electron beam emitting at cyclotron resonance Ω in a strong, uniform magnetic field. Relativistic equations of motion and first order perturbation theory are used. Results are obtained in both laboratory and normalized variables. An expression for cavity threshold gain is derived in the linear regime. An analytic expression for the electron phase angle in momentum space shows that the effect of the RF field is to form bunches that are equal to the unperturbed transit phase plus a correction term which varies as the sine of the input phase angle. The expression for the phase angle is plotted and bunching effects in and out of phase (0 and -π) with respect to the RF field are evident for detunings leading to gain and absorption, respectively. For exact resonance, field frequency ω = Ω, a bunch also forms at a phase of -π/2. This beam yields the same energy exchange with the RF field as an unbunched, (nonrelativistic) beam. 6 refs., 10 figs

Quasi-optical gyrotron development at the CRPP

International Nuclear Information System (INIS)

Tran, M.Q.

1990-09-01

The operation of the 100GHz quasi-optical (Q.O.) gyrotron of the Centre de Recherches en Physique des Plasmas in Lausanne is described. Power up to 90kW and efficiency up to 12% have been achieved. Other features of the Q.O. gyrotron include single longitudinal mode operation, frequency tunability. Second harmonic emission (200GHz) has been observed with a resonator designed for operation at the fundamental. The issues pertinent to the Q.O. gyrotron concept are also discussed. (author) 26 refs., 13 figs., 2 tabs

Nonstationary oscillations in gyrotrons revisited

International Nuclear Information System (INIS)

Dumbrajs, O.; Kalis, H.

2015-01-01

Development of gyrotrons requires careful understanding of different regimes of gyrotron oscillations. It is known that in the planes of the generalized gyrotron variables: cyclotron resonance mismatch and dimensionless current or cyclotron resonance mismatch and dimensionless interaction length complicated alternating sequences of regions of stationary, periodic, automodulation, and chaotic oscillations exist. In the past, these regions were investigated on the supposition that the transit time of electrons through the interaction space is much shorter than the cavity decay time. This assumption is valid for short and/or high diffraction quality resonators. However, in the case of long and/or low diffraction quality resonators, which are often utilized, this assumption is no longer valid. In such a case, a different mathematical formalism has to be used for studying nonstationary oscillations. One example of such a formalism is described in the present paper

Operations Studies of the Gyrotrons on DIII-D

Science.gov (United States)

Storment, Stephen; Lohr, John; Cengher, Mirela; Gorelov, Yuri; Ponce, Dan; Torrezan, Antonio

2017-10-01

The gyrotrons are high power vacuum tubes used in fusion research to provide high power density heating and current drive in precisely localized areas of the plasma. Despite the increasing experience with both the manufacture and operation of these devices, individual gyrotrons with similar design and manufacturing processes can exhibit important operational differences in terms of generated rf power, efficiency and lifetime. This report discusses differences in the performance of several gyrotrons in operation at DIII-D and presents the results of a series of measurements that could lead to improved the performance of single units based on a better understanding of the causes of these differences. The rf power generation efficiency can be different from gyrotron to gyrotron. In addition, the power loading of the collector can feature localized hot spots, where the collector can locally be close to the power deposition limits. Measurements of collector power loading provide maps of the power deposition and can provide understanding of the effect of modulation of the output rf beam on the total loading, leading to improved operational rules increasing the safety margins for the gyrotrons under different operational scenarios. Work supported by US DOE under DE-FC02-04ER54698.

MAGY: An innovative high voltage-low current power supply for gyrotron

International Nuclear Information System (INIS)

Siravo, Ugo; Alex, Juergen; Bader, Michael; Carpita, Mauro; Fasel, Damien; Gavin, Serge; Perez, Albert

2011-01-01

From the electrical point of view, the body and the anode of high power gyrotrons behave as capacitive loads. A highly dynamic power supply is, therefore, hard to achieve. The MAGY concept (Modulator for the Anode of a triode type GYrotron) embodies an innovative solution to manage the capacitive current ensuring a very low ripple on the output voltage. It consists of a series of independent, bi-directional and regulated DC sources. Compared to existing topologies, this solution requires a smaller number of power modules. It avoids internal high frequency modulation and simultaneously offers high resolution of the output voltage and a wide range of operating scenarios.

Recent result of gyrotron operation in NIFS

Directory of Open Access Journals (Sweden)

Ito Satoshi

2015-01-01

Full Text Available In the last Large Helical Device (LHD experimental campaign, a 154GHz gyrotron which had been conditioned to generate 1 MW/2 s, 0.5 MW/CW was installed for LHD experiments. Four high power gyrotrons (three-77 GHz/1~1.5 MW and one-154 GHz/1 MW and a CW gyrotron (84 GHz/0.2 MW are ready. Our experiment requires high energy and various injection patterns for Electron Cyclotron Resonance Heating (ECRH. Higher individual injection power and various injection patterns, we developed a power enhancement method by stepped anode acceleration voltage control and operated the gyrotron in the hard excitation region. These operations were realized by a remote controlled waveform generator. However the oscillation map of high power or long pulse operation in the hard excitation region were limited because in order to achieve the hard excitation region by the anode voltage control one must pass through the high anode current phase within a time short enough that the anode or the anode power supply is not overloaded. This limitation becomes more critical when the gyrotron beam current is increased in order to increase the output power. In the long pulse operation it was impossible to reach the hard excitation region in a low beam current (<10A.

Operation and control of high power Gyrotrons for ECRH systems in SST-1 and Aditya

Energy Technology Data Exchange (ETDEWEB)

Shukla, B.K., E-mail: shukla@ipr.res.in; Bora, D.; Jha, R.; Patel, Jatin; Patel, Harshida; Babu, Rajan; Dhorajiya, Pragnesh; Dalakoti, Shefali; Purohit, Dharmesh

2016-11-15

Highlights: • Operation and control of high power Gyrotrons. • Data acquisition and control (DAQ) for Gyrotron system. • Ignitron based crowbar protection. • VME and PXI based systems. - Abstract: The Electron Cyclotron Resonance Heating (ECRH) system is an important heating system for the reliable start-up of tokamak. The 42 GHz and 82.6 GHz ECRH systems are used in tokamaks SST-1 and Aditya to carry out ECRH related experiments. The Gyrotrons are high power microwave tubes used as a source for ECRH systems. The Gyrotron is a delicate microwave tube, which deliver megawatt level power at very high voltage ∼40–50 kV with the current requirement ∼10 A–50 A. The Gyrotrons are associated with the subsystems like: High voltage power supplies (Beam voltage and anode voltage), dedicated crowbar system, magnet, filament and ion pump power supplies, cooling, interlocks and a dedicated data acquisition & control (DAC) system. There are two levels of interlocks used for the protection of Gyrotron: fast interlocks (arcing, beam over current, dI/dt, anode voltage and anode over current etc.) operate within 10 μs and slow interlocks (cooling, filament, silence of Gyrotron, ion pump and magnet currents) operate within 100 ms. Two Gyrotrons (42 GHz/500 kW/500 ms and 82.6 GHz/200 kW/1000 s) have been commissioned on dummy load for full parameters. The 42 GHz ECRH system has been integrated with SST-1 & Aditya tokamak and various experiments have been carried out related to ECRH assisted breakdown and start-up of tokamak at fundamental and second harmonic. These Gyrotrons are operated with VME based data acquisition and control (DAC) system. The DAC system is capable to acquire 64 digital and 32 analog signals. The system is used to monitor & acquire the data and also used for slow interlocks for the protection of Gyrotron. The data acquired from the system are stored online on VME system and after the shot stored in a file in binary format. The MDSPlus, a set of

Electron beam instabilities in gyrotron beam tunnels

International Nuclear Information System (INIS)

Pedrozzi, M.; Alberti, S.; Hogge, J.P.; Tran, M.Q.; Tran, T.M.

1997-10-01

Electron beam instabilities occurring in a gyrotron electron beam can induce an energy spread which might significantly deteriorate the gyrotron efficiency. Three types of instabilities are considered to explain the important discrepancy found between the theoretical and experimental efficiency in the case of quasi-optical gyrotrons (QOG): the electron cyclotron maser instability, the Bernstein instability and the Langmuir instability. The low magnetic field gradient in drift tubes of QOG makes that the electron cyclotron maser instability can develop in the drift tube at very low electron beam currents. Experimental measurements show that with a proper choice of absorbing structures in the beam tunnel, this instability can be suppressed. At high beam currents, the electrostatic Bernstein instability can induce a significant energy spread at the entrance of the interaction region. The induced energy spread scales approximately linearly with the electron beam density and for QOG one observes that the beam density is significantly higher than the beam density of an equivalent cylindrical cavity gyrotron. (author) figs., tabs., refs

Development of ITER CODAC compatible gyrotron local control system and its operation

International Nuclear Information System (INIS)

Ohshima, Katsumi; Oda, Yasuhisa; Takahashi, Koji; Terakado, Masayuki; Ikeda, Ryosuke; Moriyama, Shinichi; Kajiwara, Ken; Sakamoto, Keishi; Hayashi, Kazuo

2016-03-01

In Japan Atomic Energy Agency, an ITER relevant control system for ITER gyrotron was developed according to Plant Control Design Handbook. This control system was developed based on ITER CODAC Core System and implemented state machine control of gyrotron operation system, sequential timing control of gyrotron oscillation startup, and data acquisition. The operation of ITER 170 GHz gyrotron was demonstrated with ITER relevant power supply configuration. This system is utilized for gyrotron operation test for ITER procurement. This report describes the architecture of gyrotron local control system, its basic and detailed design, and recent operation results. (author)

100 GHz, 1 MW, CW gyrotron study program. Final report

International Nuclear Information System (INIS)

Felch, K.; Bier, R.; Caplan, M.; Jory, H.

1983-09-01

The results of a study program to investigate the feasibility of various approaches in designing a 100 GHz, 1 MW CW gyrotron are presented. A summary is given of the possible configurations for a high average power, high frequency gyrotron, including an historical survey of experimental results which are relevant to the various approaches. A set of basic scaling considerations which enable qualitative comparisons between particular gyrotron interaction circuits is presented. These calculations are important in understanding the role of various electron beam and circuit parameters in achieving a viable gyrotron design. Following these scaling exercises, a series of design calculations is presented for a possible approach in achieving 100 GHz, 1 MW CW. These calculations include analyses of the electron gun and interaction circuit parts of the gyrotron, and a general analysis of other aspects of a high average power, high frequency gyrotron. Scalability of important aspects of the design to other frequencies is also discussed, as well as key technology issues

Analysis of a prototype of a novel 1.5 MW, 170 GHz coaxial cavity gyrotron

International Nuclear Information System (INIS)

Rzesnicki, T.

2007-06-01

A 170 GHz, 2 MW coaxial cavity gyrotron is under development at the Institut fuer Hochleistungsimpuls- und Mikrowellentechnik (IHM) at Forschungszentrum Karlsruhe (FZK) which will be used as a high power microwave source for heating, current drive and stability control of plasmas in the International Thermonuclear Experimental Reactor (ITER). At frequencies above about 100 GHz the output power of conventional gyrotrons with cylindrical hollow waveguide cavities is limited to 1 MW in CW operation mainly due to the high Ohmic losses and the space charge voltage depression of the electron beam. The coaxial geometry enables a reduction of the mode competition in the gyrotron resonator and decreases also the influence of the beam voltage depression. As result a very high order operating mode (for example TE34,19 at 170 GHz) can be chosen which ultimately allows to increase the output power of the gyrotron in CW operation to a value as high as 2 MW. A first prototype of the 170 GHz, 2 MW coaxial cavity gyrotron has been designed, built and experimentally tested in short pulse operation at FZK. The main goal of this work was to investigate experimentally the design of the critical gyrotron components such as electron gun, resonator and a quasi-optical RF system. Those components are same as used in the first industrial coaxial prototype gyrotron for ITER. During the experiments a strong instability was observed inside the gyrotron tube due to the excitation of parasitic low frequency oscillations. The mechanism of the oscillations has been studied and possibilities for their suppression of these oscillations are proposed and experimentally verified. The RF output system is one of the most critical components. It is responsible for the coupling of the gyrotron power out of the gyrotron by converting the microwave power generated in the TE 34,19 -mode into a fundamental free space TEM 0,0 ''Gaussian'' mode. The performance of the RF output system has been tested in low

Cusp-Gun Sixth-Harmonic Slotted Gyrotron

Science.gov (United States)

Stutzman, R. C.; McDermott, D. B.; Hirata Luhmann, Y., Jr.; Gallagher, D. A.; Spencer, T. A.

2000-10-01

A high-harmonic slotted gyrotron has been constructed at UC Davis to be driven by a 70 kV, 3.5 A, axis-encircling electron beam from a Northrop Grumman Cusp gun. The 94 GHz, slotted sixth-harmonic gyrotron is predicted to generate 50 kW with an efficiency of 20%. Using the profile of the adiabatic field reversal from the UC Davis superconducting test-magnet, EGUN simulations predict that an axis-encircling electron beam will be generated with an axial velocity spread of Δ v_z/v_z=10% for the desired velocity ratio of α =v_z/v_z=1.5. The design will also be presented for an 8th-harmonic W-band gyrotron whose magnetic field can be supplied by a lightweight permanent magnet.

5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs

Directory of Open Access Journals (Sweden)

Iwao Sasaki

2010-09-01

Full Text Available 5-Fluorouracil (5-FU is a key anticancer drug that for its broad antitumor activity, as well as for its synergism with other anticancer drugs, has been used to treat various types of malignancies. In chemotherapeutic regimens, 5-FU has been combined with oxaliplatin, irinotecan and other drugs as a continuous intravenous infusion. Recent clinical chemotherapy studies have shown that several of the regimens with oral 5-FU drugs are not inferior compared to those involving continuous 5-FU infusion chemotherapy, and it is probable that in some regimens continuous 5-FU infusion can be replaced by oral 5-FU drugs. Historically, both the pharmaceutical industry and academia in Japan have been involved in the development of oral 5-FU drugs, and this review will focus on the current knowledge of 5-FU anabolism and catabolism, and the available information about the various orally-administrable 5-FU drugs, including UFT, S-1 and capecitabine. Clinical studies comparing the efficacy and adverse events of S-1 and capecitabine have been reported, and the accumulated results should be utilized to optimize the treatment of cancer patients. On the other hand, it is essential to elucidate the pharmacokinetic mechanism of each of the newly-developed drugs, to correctly select the drugs for each patient in the clinical setting, and to further develop optimized drug derivatives.

Development of new generation software tools for simulation of electron beam formation in novel high power gyrotrons

Science.gov (United States)

Sabchevski, S.; Zhelyazkov, I.; Benova, E.; Atanassov, V.; Dankov, P.; Thumm, M.; Dammertz, G.; Piosczyk, B.; Illy, S.; Tran, M. Q.; Alberti, S.; Hogge, J.-Ph

2006-07-01

Computer aided design (CAD) based on numerical experiments performed by using adequate physical models and efficient simulation codes is an indispensable tool for development, investigation, and optimization of gyrotrons used as radiation sources for electron cyclotron resonance heating (ECRH) of fusion plasmas. In this paper, we review briefly the state-of-the-art in the field of modelling and simulation of intense, relativistic, helical electron beams formed in the electron-optical systems (EOS) of powerful gyrotrons. We discuss both the limitations of the known computer codes and the requirements for increasing their capabilities for solution of various design problems that are being envisaged in the development of the next generation gyrotrons for ECRH. Moreover, we present the concept followed by us in an attempt to unite the advantages of the modern programming techniques with self-consistent, first-principles 3D physical models in the creation of a new highly efficient and versatile software package for simulation of powerful gyrotrons.

Recent progress in fusion gyrotron development

International Nuclear Information System (INIS)

Shively, J.F.; Stone, D.S.

1981-01-01

The gyrotron, a microwave tube capable of producing high power output at millimeter wavelengths, has recently found applications for electron cyclotron resonance heating of plasmas in controlled thermonuclear fusion reactor experiments. This paper describes work in progress to develop a gyrotron oscillator to deliver 200 kW CW at 60 GHz (/lambda/sub //. 5 mm). A pulsed oscillator is described which produced over 200 kw peak power. A CW oscillator is under construction. The latest experimental results are presented

Development of gyrotrons for plasma diagnostics (invited)

International Nuclear Information System (INIS)

Woskoboinikow, P.

1986-01-01

Recent advances in high-frequency (>100 GHz) gyrotron technology are reviewed and application to millimeter/submillimeter wave plasma diagnostics is discussed. Gyrotrons have useful capabilities of high-power (>1 kW), long pulse/cw operation, narrow linewidth (<100 kHz), and good spatial mode quality with efficient (--90%) mode converters. These capabilities could be used to significantly improve collective Thomson scattering diagnostics for the study of instabilities, plasma waves, turbulence, and thermal ion fluctuations. Imaging applications with many detector arrays of plasma density, field direction, and microinstabilities may be possible with gyrotons. In a high-field compact ignition tokamak experiment a possible millimeter wave diagnostics window could be exploited by a gyrotron to measure a number of parameters, including alpha particle density and velocity distribution

A 2 MW, CW, 170 GHz gyrotron for ITER

International Nuclear Information System (INIS)

Piosczyk, B.; Arnold, A.; Alberti, S.

2003-01-01

A 140 GHz gyrotron for CW operation is under development for the stellarator W7-X. With a prototype tube a microwave output power of about 0.9 MW has been obtained in pulses up to 180 s, limited by the capability of the high voltage power supply. The development work on coaxial cavity gyrotrons has demonstrated the feasibility of manufacturing of a 2 MW, CW 170 GHz tube that could be used for ITER. The problems specific to the coaxial arrangement have been investigated and all relevant information needed for an industrial realization of a coaxial gyrotron have been obtained in short pulse experiments (up to 17 ms). The suitability of critical components for a 2 MW, CW coaxial gyrotron has been studied and a first integrated design has been done. (author)

Velocity diagnostics of electron beams within a 140 GHz gyrotron

International Nuclear Information System (INIS)

Polevoy, J.T.

1989-06-01

Experimental measurements of the average axial velocity v parallel of the electron beam within the M.I.T. 140 GHz MW gyrotron have been performed. The method involves the simultaneous measurement of the radial electrostatic potential of the electron beam V p and the beam current I b . V p is measured through the use of a capacitive probe installed near or within the gyrotron cavity, while I b is measured with a previously installed Rogowski coil. Three capacitive probes have been designed and built, and two have operated within the gyrotron. The probe results are repeatable and consistent with theory. The measurements of v parallel and calculations of the corresponding transverse to longitudinal beam velocity ratio α = v perpendicular /v parallel at the cavity have been made at various gyrotron operation parameters. These measurements will provide insight into the causes of discrepancies between theoretical rf interaction efficiencies and experimental efficiencies obtained in experiments with the M.I.T. 140 GHz MW gyrotron. The expected values of v parallel and α are determined through the use of a computer code entitled EGUN. EGUN is used to model the cathode and anode regions of the gyrotron and it computes the trajectories and velocities of the electrons within the gyrotron. There is good correlation between the expected and measured values of α at low α, with the expected values from EGUN often falling within the standard errors of the measured values. 10 refs., 29 figs., 2 tabs

Velocity diagnostics of electron beams within a 140 GHz gyrotron

Science.gov (United States)

Polevoy, Jeffrey Todd

1989-06-01

Experimental measurements of the average axial velocity v(sub parallel) of the electron beam within the M.I.T. 140 GHz MW gyrotron have been performed. The method involves the simultaneous measurement of the radial electrostatic potential of the electron beam V(sub p) and the beam current I(sub b). The V(sub p) is measured through the use of a capacitive probe installed near or within the gyrotron cavity, while I(sub b) is measured with a previously installed Rogowski coil. Three capacitive probes have been designed and built, and two have operated within the gyrotron. The probe results are repeatable and consistent with theory. The measurements of v(sub parallel) and calculations of the corresponding transverse to longitudinal beam velocity ratio (alpha) = v(sub perpendicular)/v(sub parallel) at the cavity have been made at various gyrotron operation parameters. These measurements will provide insight into the causes of discrepancies between theoretical RF interaction efficiencies and experimental efficiencies obtained in experiments with the M.I.T. 140 GHz MW gyrotron. The expected values of v(sub parallel) and (alpha) are determined through the use of a computer code (EGUN) which is used to model the cathode and anode regions of the gyrotron. It also computes the trajectories and velocities of the electrons within the gyrotron. There is good correlation between the expected and measured values of (alpha) at low (alpha), with the expected values from EGUN often falling within the standard errors of the measured values.

Time-dependent spectrum analysis of high power gyrotrons

Energy Technology Data Exchange (ETDEWEB)

Schlaich, Andreas

2015-07-01

In this work, an investigation of vacuum electronic oscillators capable of generating multi-megawatt continuous wave output power in the millimeter-wave range (so-called gyrotrons) through spectral measurements is presented. The centerpiece is the development of a measurement system with a high dynamic range (50-60 dB) for time-dependent spectrum analysis, covering the frequency range 100-170 GHz with instantaneous bandwidths of 6-12 GHz. Despite relying on heterodyne reception through harmonic mixers, the Pulse Spectrum Analysis (PSA) system maintains RF unambiguity in the spectrogram output through the application of a novel RF reconstruction technique. Using the new possibilities, a wide range of spectral phenomena in gyrotrons has been investigated, such as cavity mode jumps, lowfrequency modulation, frequency tuning in long pulses and the spectral behavior during the presence of an RF window arc. A dedicated investigation on parasitic RF oscillations in W7-X gyrotrons combining several analysis techniques led to the conclusion that after-cavity oscillations can be physical reality in high power gyrotrons, and are the probable cause for the undesired signals observed. Apart from systematic parameter sweeps using the PSA system, an analytical dispersion analysis in the Brillouin diagram was applied, and numerical gyrotron interaction simulations of unprecedented extent were conducted. Furthermore, the improved frequency measurement capabilities were employed to analyze the frequency tuning through thermal expansion and electrostatic neutralization caused by ionization inside the tube in long-pulse operation. By macroscopically modeling the gas dynamics and ionization processes in combination with a fitting process, the time dependences of the two processes could be investigated. In doing so, indication was found that the neutralization in W7-X gyrotrons amounts to only 60% of the electrostatic depression voltage, instead of 100% as widely believed for

Time-dependent spectrum analysis of high power gyrotrons

International Nuclear Information System (INIS)

Schlaich, Andreas

2015-01-01

In this work, an investigation of vacuum electronic oscillators capable of generating multi-megawatt continuous wave output power in the millimeter-wave range (so-called gyrotrons) through spectral measurements is presented. The centerpiece is the development of a measurement system with a high dynamic range (50-60 dB) for time-dependent spectrum analysis, covering the frequency range 100-170 GHz with instantaneous bandwidths of 6-12 GHz. Despite relying on heterodyne reception through harmonic mixers, the Pulse Spectrum Analysis (PSA) system maintains RF unambiguity in the spectrogram output through the application of a novel RF reconstruction technique. Using the new possibilities, a wide range of spectral phenomena in gyrotrons has been investigated, such as cavity mode jumps, lowfrequency modulation, frequency tuning in long pulses and the spectral behavior during the presence of an RF window arc. A dedicated investigation on parasitic RF oscillations in W7-X gyrotrons combining several analysis techniques led to the conclusion that after-cavity oscillations can be physical reality in high power gyrotrons, and are the probable cause for the undesired signals observed. Apart from systematic parameter sweeps using the PSA system, an analytical dispersion analysis in the Brillouin diagram was applied, and numerical gyrotron interaction simulations of unprecedented extent were conducted. Furthermore, the improved frequency measurement capabilities were employed to analyze the frequency tuning through thermal expansion and electrostatic neutralization caused by ionization inside the tube in long-pulse operation. By macroscopically modeling the gas dynamics and ionization processes in combination with a fitting process, the time dependences of the two processes could be investigated. In doing so, indication was found that the neutralization in W7-X gyrotrons amounts to only 60% of the electrostatic depression voltage, instead of 100% as widely believed for

Perspective gyrotron with mode converter for co- and counter-rotation operating modes

Energy Technology Data Exchange (ETDEWEB)

Chirkov, A. V.; Kuftin, A. N. [Institute of Applied Physics, Russian Academy of Sciences, 46 Ul' yanov Street, 603950 Nizhny Novgorod (Russian Federation); Denisov, G. G. [Institute of Applied Physics, Russian Academy of Sciences, 46 Ul' yanov Street, 603950 Nizhny Novgorod (Russian Federation); University of Nizhny Novgorod, 23 Prospekt Gagarina, 603950 Nizhny Novgorod (Russian Federation)

2015-06-29

A gyrotron oscillator operating efficiently at modes of both rotations was developed and tested. The gyrotron operation can be switched between two modes: co- and counter rotating ones with respect to electron rotation in a resonance magnetic field. A synthesized mode converter provides output of both waves in the form of two different paraxial wave beams corresponding to direction of the mode rotation. Measured gyrotron power (up to 2 MW), interaction efficiency (34%), and diffraction losses in the mode converter (≈2%) agree well with the design values. The proposed gyrotron scheme alloys principal enhancement in the device parameters—possibility of electronic switching of output wave beam direction and possibility to arrange an effective scheme to provide frequency/phase locking of a gyrotron-oscillator.

Perspective gyrotron with mode converter for co- and counter-rotation operating modes

International Nuclear Information System (INIS)

Chirkov, A. V.; Kuftin, A. N.; Denisov, G. G.

2015-01-01

A gyrotron oscillator operating efficiently at modes of both rotations was developed and tested. The gyrotron operation can be switched between two modes: co- and counter rotating ones with respect to electron rotation in a resonance magnetic field. A synthesized mode converter provides output of both waves in the form of two different paraxial wave beams corresponding to direction of the mode rotation. Measured gyrotron power (up to 2 MW), interaction efficiency (34%), and diffraction losses in the mode converter (≈2%) agree well with the design values. The proposed gyrotron scheme alloys principal enhancement in the device parameters—possibility of electronic switching of output wave beam direction and possibility to arrange an effective scheme to provide frequency/phase locking of a gyrotron-oscillator

The 140 GHZ, 1 MW Gyrotron - Status and Recent Results

Science.gov (United States)

Gantenbein, G.; Dammertz, G.; Illy, S.; Kern, S.; Leonhardt, W.; Piosczyk, B.; Schmid, M.; Thumm, M.; Braune, H.; Erckmann, V.; Laqua, H. P.; Michel, G.; Kasparek, W.; Lechte, C.; Legrand, F.; Lievin, C.; Prinz, O.

2009-04-01

A 10 MW ECRH system is currently under construction for the stellarator W7-X which will be built up and operated by IPP in Greifswald, Germany. The present status of the complete system is reported in [1]. The RF power will be provided by 10 gyrotrons. A European collaboration has been established to develop and build the 10 gyrotrons each with an output power of 1 MW for continuous wave (CW) operation [2]. Nine gyrotrons are being manufactured by Thales Electron Devices (TED), Vélizy, France, one gyrotron was produced by CPI, Palo Alto, CA and passed the acceptance tests at IPP. The acceptance tests of the TED gyrotrons are performed at the test stand at FZK and on site at IPP. The first series tube yielded a total output power of 0.98 MW, with an efficiency of 31 % (without a single stage depressed collector) in short pulse operation and of 0.92 MW in pulses of 1800 s (efficiency of almost 45 % at a depression voltage of 29 kV) [3], The Gaussian mode output power was 0.91 MW. The RF power, measured in a calorimetric load at the end of a 25 m long quasi-optical transmission line with seven mirrors, was 0.87 MW. In this contribution typical results of the next series gyrotrons will be reported.

Stability and nonlinear dynamics of gyrotrons at cyclotron harmonics

International Nuclear Information System (INIS)

Saraph, G.P.; Nusinovich, G.S.; Antonsen, T.M. Jr.; Levush, B.

1992-01-01

Gyrotrons operating at higher harmonics of the cyclotron frequency can overcome the frequency limitations caused by achievable strength of the magnetic field. However, the excitation of modes at the fundamental frequency exhibit a major problem for stable operation of harmonic gyrotron at high power with high efficiency. Therefore the issues of stability of gyrotron operation at the cyclotron harmonics and nonlinear dynamics of mode interaction are of great importance. The results of the authors stability analysis and multimode simulation are presented here. A detailed nonlinear theory of steady state single mode operation at cyclotron harmonics has been presented previously, taking into account beam-wave coupling and nonlinear gain function at cyclotron harmonics. A set of equations describing low gain regime interaction of modes resonant at different cyclotron harmonics was studied before. The multifrequency time-dependent nonlinear analysis presented here is based on previous gyrotron studies and beam-wave interaction at cyclotron harmonics. The authors have determined the parameter space for stable single mode operation at the second harmonic. The nonlinear dynamics of mode evolution and mode interaction for a harmonic gyrotron is presented. A new nonlinear effect in which the parasite at the fundamental harmonic helps excite the operating mode at the second harmonic has been demonstrated

Problem-Oriented Simulation Packages and Computational Infrastructure for Numerical Studies of Powerful Gyrotrons

International Nuclear Information System (INIS)

Damyanova, M; Sabchevski, S; Vasileva, E; Balabanova, E; Zhelyazkov, I; Dankov, P; Malinov, P

2016-01-01

Powerful gyrotrons are necessary as sources of strong microwaves for electron cyclotron resonance heating (ECRH) and electron cyclotron current drive (ECCD) of magnetically confined plasmas in various reactors (most notably ITER) for controlled thermonuclear fusion. Adequate physical models and efficient problem-oriented software packages are essential tools for numerical studies, analysis, optimization and computer-aided design (CAD) of such high-performance gyrotrons operating in a CW mode and delivering output power of the order of 1-2 MW. In this report we present the current status of our simulation tools (physical models, numerical codes, pre- and post-processing programs, etc.) as well as the computational infrastructure on which they are being developed, maintained and executed. (paper)

Improved Collectors for High Power Gyrotrons

International Nuclear Information System (INIS)

Ives, R. Lawrence; Singh, Amarjit; Read, Michael; Borchard, Philipp; Neilson, Jeff

2009-01-01

High power gyrotrons are used for electron cyclotron heating, current drive and parasitic mode suppression in tokamaks for fusion energy research. These devices are crucial for successful operation of many research programs around the world, including the ITER program currently being constructed in France. Recent gyrotron failures resulted from cyclic fatigue of the copper material used to fabricated the collectors. The techniques used to collect the spent beam power is common in many gyrotrons produced around the world. There is serious concern that these tubes may also be at risk from cyclic fatigue. This program addresses the cause of the collector failure. The Phase I program successfully demonstrated feasibility of a mode of operation that eliminates the cyclic operation that caused the failure. It also demonstrated that new material can provide increased lifetime under cyclic operation that could increase the lifetime by more than on order of magnitude. The Phase II program will complete that research and develop a collector that eliminates the fatigue failures. Such a design would find application around the world.

Thermal analysis of gyrotron traveling-wave tube collector

International Nuclear Information System (INIS)

Zheng Zhiqing; Luo Yong; Jiang Wei; Tang Yong

2013-01-01

In order to solve cooling problem of the gyrotron traveling-wave tube(TWT) collector and guarantee the gyrotron TWT's reliability and stability, the electron trajectories in the gyrotron TWT are simulated using CST electron simulation software. Thermal analysis of the collector with finite element software ANSYS is performed. The ways of applying boundary that affects the distribution of collector temperature are compared. The influence of the water temperature and flow rate on collector temperature distribution under actual heat fluxes (boundary condition) is researched. The size and number of collector fins are optimized, and a relatively perfect structure is obtained finally. The result estimated by simulation is consistent with the experiment and proves that the model and method employed in this work are suitable. (authors)

ITER ECFR Coaxial gyrotron and window development (EU-T360). Pt. 1: Coaxial gyrotron development. Final report

International Nuclear Information System (INIS)

Piosczyk, B.; Braz, O.; Dammertz, G.; Kuntze, G.; Michel, G.; Moebius, A.; Thumm, M.

1999-02-01

Based on the experience gained with the inverse magnetron injection gun (IMIG) for coaxial cavity gyrotrons, a new 4.5 MW electron gun for operation at a cathode voltage of 90 kV and a beam current of 50 A has been designed and is currently under fabrication at Thomson Tubes Electroniques (TTE). The gun is of the diode type. Different from the LaB 6 IMIG currently used, the emission of the electrons will not be directed towards the coaxial insert but towards the anode similar like in conventional MIG gyrotron electron guns. The inner conductor is supported from the gun inner conductor side and can be aligned in a reproducible way in the fully assembled tube. The insert is cooled as required for operation at long pulses up to cw. The cathode will be equipped with an impregnated tungsten matrix emitter as used in industrial tubes. A 160/170 GHz, 1.5 MW, 100 ms pulse length coaxial gyrotron employing the new electron gun and a single-stage depressed collector has been designed. The advanced quasi-optical converter for transforming the TE -31,17 cavity mode at 165 GHz into a single RF-output wave beam (only one output window) consists of a simple launcher and two mirrors. The first mirror is quasi-elliptical and the second mirror has a non-quadratic phase-correcting surface to generate an approximately homogeneous RF-field distribution with a high fundamental Gaussian content in the window plane. First test experiments with the new gyrotron have been performed employing the available LaB 6 -IMIG. (orig.)

Review of gyrotron development at the Centre de Recherche en Physique des Plasmas

International Nuclear Information System (INIS)

Tran, M.Q.

1990-01-01

Gyrotron development activities at the Centre de Recherche en Physique des Plasmas in Lausanne are directed along two directions, quasi optical gyrotrons and, with less emphasis, cylindrical cavity gyrotrons. This paper will review the recent work performed in these two fields. (author) 9 refs., 5 figs

Experimental investigation of plasma-neutralized operation of a gyrotron

International Nuclear Information System (INIS)

Kirkpatrick, D.A.; Sullivan, C.; Gold, S.H.; Manheimer, W.M.; Levush, B.; Antonsen, T.M.

1989-01-01

The authors present plans and preliminary results of an experiment to investigate the effects of a neutralizing background plasma on the operation of a gyrotron oscillator. Previous experiments operating without a neutralizing background plasma achieved output powers P = 100 - 250MW at a frequency f = 35 GHz, with beam voltages in the range V = 0.60 - 1.35MV, and beam currents I = 1 -3kA. A completely ionized plasma is injected into a gyrotron interaction region from an upstream array of plasma guns. The peak plasma density available from the plasma guns exceeds n p > 10 13 cm -3 . The plasma density is measured by 70 GHz microwave interferometry and Langmuir probes. A high current electron beam from a field emission electron gun enters the plasma-filled gyrotron cavity from the upstream side. The density of the neutralizing plasma is varied by changing the delay between the firing of plasma guns and the VEBA accelerator. The authors present measurements of the transmitted electron beam current. Subsequent design of a gyrotron oscillator which utilizes the enhanced capabilities are presented

Experimental measurements on a 100 GHz frequency tunable quasioptical gyrotron

International Nuclear Information System (INIS)

Alberti, S.; Tran, M.Q.; Hogge, J.P.; Tran, T.M.; Bondeson, A.; Muggli, P.; Perrenoud, A.; Joedicke, B.; Mathews, H.G.

1990-01-01

Experiments on a 100 GHz quasioptical (QO) gyrotron operating at the fundamental (ω=Ω ce ) are described. Powers larger than 90 kW at an efficiency of about 12% were achieved. Depending on the electron beam parameters, the frequency spectrum of the output can be either single moded or multimoded. One of the main advantages of the QO gyrotron over the conventional gyrotron is its continuous frequency tunability. Various techniques to tune the output frequency have been tested, such as changing the mirror separation, the beam voltage, or the main magnetic field. Within the limitations of the present setup, 5% tunability was achieved. The QO gyrotron designed for operation at the fundamental frequency exhibits simultaneous emission at 100 GHz (fundamental) and 200 GHz (second harmonic). For a beam current of 4 A, 20% of the total rf power is emitted at the second harmonic

Frequency-agile gyrotron for electron decoupling and pulsed dynamic nuclear polarization

Science.gov (United States)

Scott, Faith J.; Saliba, Edward P.; Albert, Brice J.; Alaniva, Nicholas; Sesti, Erika L.; Gao, Chukun; Golota, Natalie C.; Choi, Eric J.; Jagtap, Anil P.; Wittmann, Johannes J.; Eckardt, Michael; Harneit, Wolfgang; Corzilius, Björn; Th. Sigurdsson, Snorri; Barnes, Alexander B.

2018-04-01

We describe a frequency-agile gyrotron which can generate frequency-chirped microwave pulses. An arbitrary waveform generator (AWG) within the NMR spectrometer controls the microwave frequency, enabling synchronized pulsed control of both electron and nuclear spins. We demonstrate that the acceleration of emitted electrons, and thus the microwave frequency, can be quickly changed by varying the anode voltage. This strategy results in much faster frequency response than can be achieved by changing the potential of the electron emitter, and does not require a custom triode electron gun. The gyrotron frequency can be swept with a rate of 20 MHz/μs over a 670 MHz bandwidth in a static magnetic field. We have already implemented time-domain electron decoupling with dynamic nuclear polarization (DNP) magic angle spinning (MAS) with this device. In this contribution, we show frequency-swept DNP enhancement profiles recorded without changing the NMR magnet or probe. The profile of endofullerenes exhibits a DNP profile with a <10 MHz linewidth, indicating that the device also has sufficient frequency stability, and therefore phase stability, to implement pulsed DNP mechanisms such as the frequency-swept solid effect. We describe schematics of the mechanical and vacuum construction of the device which includes a novel flanged sapphire window assembly. Finally, we discuss how commercially available continuous-wave gyrotrons can potentially be converted into similar frequency-agile high-power microwave sources.

Electron gun simulation for 95 GHz gyrotron

Energy Technology Data Exchange (ETDEWEB)

Singh, Udaybir; Kumar, Nitin; Sinha, A.K., E-mail: uday.ceeri@gmail.com, E-mail: aksinha@ceeri.ernet.in [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute, Pilani (India); Purohit, L.P. [Department of Physics, Gurukul Kangri Vishwavidyalaya, Haridwar (India)

2011-07-01

A triode type Magnetron Injection Gun (MIG) for a 2 MW, 95 GHz Gyrotron has been designed by using commercially available code EGUN and another in-house developed code MIGANS. The operating mode of the gyrotron is TE{sub 24.8} and it is operated in the fundamental harmonic. The operating voltages of the modulating anode and the accelerating anode are 61 kV and 85 kV respectively. The parametric dependences of modulating anode voltage and cathode magnetic field on the beam quality have also been studied. (author)

Electron gun simulation for 95 GHz gyrotron

International Nuclear Information System (INIS)

Singh, Udaybir; Kumar, Nitin; Sinha, A.K.; Purohit, L.P.

2011-01-01

A triode type Magnetron Injection Gun (MIG) for a 2 MW, 95 GHz Gyrotron has been designed by using commercially available code EGUN and another in-house developed code MIGANS. The operating mode of the gyrotron is TE 24.8 and it is operated in the fundamental harmonic. The operating voltages of the modulating anode and the accelerating anode are 61 kV and 85 kV respectively. The parametric dependences of modulating anode voltage and cathode magnetic field on the beam quality have also been studied. (author)

Asymmetric modes in gyrotron tubes and their experimental study

International Nuclear Information System (INIS)

Garin, P.; Jedar, E.; Jendrzejczak, G.; mourier, G.; Payen, F.; Teyssier, L.

1989-01-01

High power gyrotron tubes suffer from the competition between oscillations on different modes of the resonant cavity. Different techniques for mode selection are outlined and the advantages of non symmetric modes are indicated. Their experimental study is described on a 100 GHz-200 kW - 100 ms - TE34 gyrotron. Some possible extrapolations are briefly presented. (author). 6 refs.; 4 figs

Accurate frequency measurements on gyrotrons using a ''gyro-radiometer''

International Nuclear Information System (INIS)

Rebuffi, L.

1986-08-01

Using an heterodyne system, called ''Gyro-radiometer'', accurated frequency measurements have been carried out on VARIAN 60 GHz gyrotrons. Changing the principal tuning parameters of a gyrotron, we have detected frequency variations up to 100 MHz, ∼ 40 MHz frequency jumps and smaller jumps (∼ 10 MHz) when mismatches in the transmission line were present. FWHM bandwidth of 300 KHz, parasitic frequencies and frequency drift during 100 msec pulses have also been observed. An efficient method to find a stable-, high power-, long pulse-working point of a gyrotron loaded by a transmission line, has been derived. In general, for any power value it is possible to find stable working conditions tuning the principal parameters of the tube in correspondance of a maximum of the emitted frequency

Circuit design and simulation of a HV-supply controlling the power of 140 GHz 1 MW gyrotrons for ECRH on W7-X

International Nuclear Information System (INIS)

Brand, P.; Mueller, G.A.

2003-01-01

For plasma heating by ECR in the Stellarator W7-X under construction, 140 GHz gyrotrons with 1 MW cw output power are under development. These tubes have a voltage depressed collector for electron energy recovery. Each gyrotron is fed by two high-voltage sources: a high-power supply for driving the electron beam and a precision low-power supply for beam acceleration. In addition, a protection system with a thyratron crowbar for fast power removal in case of gyrotron arcing is installed. The low-power high-voltage source for beam acceleration is realized by a high-voltage servo-amplifier driving the depression voltage such that the influence of the voltage noise of the main high-power supply on the acceleration voltage is suppressed by feed-back control of the amplifier. Design and simulation of the servo-amplifier by PSpice is presented

Development of MW gyrotrons for fusion devices by University of Tsukuba

International Nuclear Information System (INIS)

Minami, R.; Kariya, T.; Imai, T.; Numakura, T.; Endo, Y.; Nakabayashi, H.; Eguchi, T.; Shimozuma, T.; Kubo, S.; Yoshimura, Y.; Igami, H.; Takahashi, H.; Mutoh, T.; Ito, S.; Idei, H.; Zushi, H.; Yamaguchi, Y.; Sakamoto, Keishi; Mitsunaka, Y.

2012-11-01

Over-1 MW power gyrotrons for electron cyclotron heating (ECH) have been developed in the joint program of NIFS and University of Tsukuba. The obtained maximum outputs are 1.9 MW for 0.1 s on the 77 GHz Large Helical Device (LHD) tube and 1.0 MW for 1 ms on the 28 GHz GAMMA 10 one, which are new records in these frequency ranges. In long pulse operation, 300 kW for 40 min at 77 GHz and 540 kW for 2 s at 28 GHz were achieved. A new program of 154 GHz 1 MW development has started for high density plasma heating in LHD and the first tube has been fabricated. These lower frequency tubes like 77 GHz or 28 GHz one are also important for advanced magnetic fusion devices, which use Electron Bernstein Wave (EBW) heating / current drive. As a next activity of 28 GHz gyrotron, we have already started the development of over-1.5 MW gyrotron and a new design study of 28 GHz / 35 GHz dual frequency gyrotron, which indicates the practicability of the multi-purpose gyrotron. (author)

Fast power measurement on a 30 GHz/15 kW gyrotron

International Nuclear Information System (INIS)

Saala, G.

2004-09-01

This work has been developed in the scope of a study-thesis at the Universitaet Karlsruhe (TH). The realization took place at the Institut fuer Hochleistungsimpuls- und Mikrowellentechnik (IHM) at the Forschungszentrum Karlsruhe (FZK). The aim was to investigate the possibilities of a fast power measurement at a compact, industrial gyrotron-system. To measure the output-power a small fraction of the gyrotron microwave radiation is coupled out and analyzed using a diode-detector. At the beginning of the work a mirror of the quasi-optical transmission line with a built in λ/4-coupler was available. This built-in coupler and other coupling structures which have been set up during this work have been characterized. To be able to perform reproduceable measurements several computer programs have been developed. Using these programs the gyrotron-system can be remote-controlled from a PC. The diode-detector signal has been analyzed under different conditions of gyrotron operation with respect to its short-term- and long-term-stability. After that the dependency of the calorimetrically measured output-power of the gyrotron has been used to calibrate the diode-voltage. (orig.)

Diamond window and its application to ITER gyrotron

International Nuclear Information System (INIS)

Sakamoto, K.

1999-01-01

On the background of having to reduce the overall cost for ITER to 50% it is proposed to replace conventional glass windows on gyrotrons by diamonds. The successful production and testing of such diamond windows is reported. A diamond window can transmit 5 times more power than usual double disk transmission windows while only costing 3 times as much. As a tradeoff, the gyrotrons could be replaced by more powerful ones and one would need fewer of them

First 200 kW CW operation of a 60 GHz gyrotron

International Nuclear Information System (INIS)

Jory, H.; Bier, R.; Evans, S.; Felch, K.; Fox, L.; Huey, H.; Shively, J.; Spang, S.

1983-01-01

The gyrotron is a microwave tube which employs the electron cyclotron maser interaction to produce high power output at millimeter wavelengths. It has important and growing applications for heating of plasmas in controlled thermonuclear fusion experiments. The Varian 60 GHz gyrotron has recently generated microwave power in excess of 200 kW during CW operation, wth excellent dynamic range and operating stability. This is the highest average power ever produced by a microwave tube in the millimeter wave region. A description of the gyrotron design and test results are presented

Neutron generator for BNCT based on high current ECR ion source with gyrotron plasma heating.

Science.gov (United States)

Skalyga, V; Izotov, I; Golubev, S; Razin, S; Sidorov, A; Maslennikova, A; Volovecky, A; Kalvas, T; Koivisto, H; Tarvainen, O

2015-12-01

BNCT development nowadays is constrained by a progress in neutron sources design. Creation of a cheap and compact intense neutron source would significantly simplify trial treatments avoiding use of expensive and complicated nuclear reactors and accelerators. D-D or D-T neutron generator is one of alternative types of such sources for. A so-called high current quasi-gasdynamic ECR ion source with plasma heating by millimeter wave gyrotron radiation is suggested to be used in a scheme of D-D neutron generator in the present work. Ion source of that type was developed in the Institute of Applied Physics of Russian Academy of Sciences (Nizhny Novgorod, Russia). It can produce deuteron ion beams with current density up to 700-800 mA/cm(2). Generation of the neutron flux with density at the level of 7-8·10(10) s(-1) cm(-2) at the target surface could be obtained in case of TiD2 target bombardment with deuteron beam accelerated to 100 keV. Estimations show that it is enough for formation of epithermal neutron flux with density higher than 10(9) s(-1) cm(-2) suitable for BNCT. Important advantage of described approach is absence of Tritium in the scheme. First experiments performed in pulsed regime with 300 mA, 45 kV deuteron beam directed to D2O target demonstrated 10(9) s(-1) neutron flux. This value corresponds to theoretical estimations and proofs prospects of neutron generator development based on high current quasi-gasdynamic ECR ion source. Copyright © 2015 Elsevier Ltd. All rights reserved.

Quasi-optical internal mode converters for 110 GHz gyrotrons

International Nuclear Information System (INIS)

Harper, B.M.; Lorbeck, J.A.; Vernon, R.J.

1995-01-01

Many early gyrotrons had a microwave output in the same mode that was produced in the microwave cavity, e.g. the TE 02 mode. These modes were often converted outside of the tube to a more desirable mode for plasma heating using a system of perturbed-wall waveguide mode converters. The current generation of gyrotrons commonly have cavity modes with a high azimuthal index, such as the rotating TE 22,6 mode. Mode conversion by means of waveguide mode converters is not usually practical for such cases. However, an output of a Gaussian beam or other desirable field pattern can be obtained by using a Vlasov-type launcher feeding a series of two or more reflectors. This system may be placed outside or inside of the gyrotron but there are advantages to placing it within the tube, e.g. allowing for a larger collector and smaller reflectors. When such a converter system is placed inside the gyrotron, it is usually preferable to use a modification to the simple Vlasov launcher such as the Denisov-type launcher, which incorporates a series of perturbations within it. The authors have designed both internal and external versions of such quasi-optical converters. They discuss an internal converter which was designed for use inside of a Varian 110 GHz gyrotron producing the TE 22,6 cavity mode. This design consists of four reflectors which are fed by a Denisov-type launcher. Design techniques for the reflector system are discussed and experimental results are presented

Modeling of mode purity in high power gyrotrons

International Nuclear Information System (INIS)

Cai, S.Y.; Antonsen, T.M. Jr.; Saraph, G.P.

1993-01-01

Spurious mode generation at the same frequency of the operational mode in a high power gyrotron can significantly reduce the power handling capability and the stability of a gyrotron oscillator because these modes are usually not matched at the output window and thus have high absorption and reflection rates. To study the generation of this kind of mode, the authors developed a numerical model based on an existing multimode self-consistent time-dependent computer code. This model includes both TE and TM modes and accounts for mode transformations due to the waveguide inhomogeneity. With this new tool, they study the mode transformation in the gyrotron and the possibility of excitation of parasitic TE and TM modes in the up taper section due to the gyroklystron mechanism. Their preliminary results show moderate excitation of both TE and TM modes at the same frequency as the main operating mode at locations near their cutoff. Details of the model and further simulation results will be presented

Continuous-Wave Operation of a Frequency-Tunable 460-GHz Second-Harmonic Gyrotron for Enhanced Nuclear Magnetic Resonance

Science.gov (United States)

Torrezan, Antonio C.; Han, Seong-Tae; Mastovsky, Ivan; Shapiro, Michael A.; Sirigiri, Jagadishwar R.; Temkin, Richard J.; Griffin, Robert G.; Barnes, Alexander B.

2012-01-01

The design, operation, and characterization of a continuous-wave (CW) tunable second-harmonic 460-GHz gyrotron are reported. The gyrotron is intended to be used as a submillimeter-wave source for 700-MHz nuclear magnetic resonance experiments with sensitivity enhanced by dynamic nuclear polarization. The gyrotron operates in the whispering-gallery mode TE11,2 and has generated 16 W of output power with a 13-kV 100-mA electron beam. The start oscillation current measured over a range of magnetic field values is in good agreement with theoretical start currents obtained from linear theory for successive high-order axial modes TE11,2,q. The minimum start current is 27 mA. Power and frequency tuning measurements as a function of the electron cyclotron frequency have also been carried out. A smooth frequency tuning range of 1 GHz was obtained for the operating second-harmonic mode either by magnetic field tuning or beam voltage tuning. Long-term CW operation was evaluated during an uninterrupted period of 48 h, where the gyrotron output power and frequency were kept stable to within ±0.7% and ±6 ppm, respectively, by a computerized control system. Proper operation of an internal quasi-optical mode converter implemented to transform the operating whispering-gallery mode to a Gaussian-like beam was also verified. Based on the images of the gyrotron output beam taken with a pyroelectric camera, the Gaussian-like mode content of the output beam was computed to be 92% with an ellipticity of 12%. PMID:23761938

Megawatt Power Level 120 GHz Gyrotrons for ITER Start-Up

Energy Technology Data Exchange (ETDEWEB)

Choi, E M; Marchewka, C; Mastovsky, I; Shapiro, M A; Sirigiri, J R; Temkin, R J [MIT - Plasma Science and Fusion Center, NW16-186, 167 Albany Street, Cambridge, MA 02139 (United States)

2005-01-01

We report operation of a 110 GHz gyrotron with 1.67 MW of output power measured in short pulses (3{mu}s) at an efficiency of 42% in the TE{sub 22,6} mode. We also present a preliminary design of a 1 MW, 120 GHz gyrotron for ITER start-up with an efficiency greater than 50%.

Megawatt Power Level 120 GHz Gyrotrons for ITER Start-Up

International Nuclear Information System (INIS)

Choi, E M; Marchewka, C; Mastovsky, I; Shapiro, M A; Sirigiri, J R; Temkin, R J

2005-01-01

We report operation of a 110 GHz gyrotron with 1.67 MW of output power measured in short pulses (3μs) at an efficiency of 42% in the TE 22,6 mode. We also present a preliminary design of a 1 MW, 120 GHz gyrotron for ITER start-up with an efficiency greater than 50%

Research on a 170 GHz, 2 MW coaxial cavity gyrotron with inner-outer corrugation

Energy Technology Data Exchange (ETDEWEB)

Hou, Shenyong, E-mail: houshenyong@sohu.com [Yangtze Normal University, Chongqing, 408001 (China); Yu, Sheng; Li, Hongfu [University of Electronics Science and Technology of China, Chengdu 610054 (China)

2015-03-15

In this paper, a coaxial cavity gyrotron with inner-outer corrugation is researched. The electron kineto-equations and the first order transmission line equations of the gyrotron are derived from Lorentz force equation and the transmission line theory, respectively. And then, a 2 MW, 170 GHz coaxial cavity gyrotron with inner-outer corrugation is designed. By means of numerical calculation, the beam-wave interaction of the coaxial cavity gyrotron with inner-outer corrugation is investigated. Results show that the efficient and the outpower of the gyrotron are 42.3% and 2.38 MW, respectively.

Electron beam emission and interaction of double-beam gyrotron

International Nuclear Information System (INIS)

Singh, Udaybir; Kumar, Anil; Kumar, Nitin; Kumar, Narendra; Pratap, Bhanu; Purohit, L.P.; Sinha, A.K.

2012-01-01

Highlights: ► The complete electrical design of electron gun and interaction structure of double-beam gyrotron. ► EGUN code is used for the simulation of electron gun of double-beam gyrotron. ► MAGIC code is used for the simulation of interaction structure of double-beam gyrotron. ► Design validations with other codes. - Abstract: This paper presents the numerical simulation of a double-beam magnetron injection gun (DB-MIG) and beam-wave interaction for 60 GHz, 500 kW gyrotron. The beam-wave interaction calculations, power and frequency growth estimation are performed by using PIC code MAGIC. The maximum output power of 510 kW at 41.5% efficiency, beam currents of 6 A and 12 A, electron beam velocity ratios of 1.41 and 1.25 and beam voltage of 69 kV are estimated. To obtain the design parameters, the DB-MIG with maximum transverse velocity spread less than 5% is designed. The computer simulations are performed by using the commercially available code EGUN and the in-house developed code MIGANS. The simulated results of DB-MIG design obtained by using the EGUN code are also validated with another trajectory code TRAK, which are in good agreement.

Electron beam emission and interaction of double-beam gyrotron

Energy Technology Data Exchange (ETDEWEB)

Singh, Udaybir, E-mail: uday.ceeri@gmail.com [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute (CEERI), Council of Scientific and Industrial Research (CSIR), Pilani, Rajasthan 333031 (India); Department of Physics, Gurukul Kangri University, Haridwar 249404 (India); Kumar, Anil [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute (CEERI), Council of Scientific and Industrial Research (CSIR), Pilani, Rajasthan 333031 (India); Kumar, Nitin, E-mail: nitin_physika@rediffmail.com [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute (CEERI), Council of Scientific and Industrial Research (CSIR), Pilani, Rajasthan 333031 (India); Kumar, Narendra; Pratap, Bhanu [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute (CEERI), Council of Scientific and Industrial Research (CSIR), Pilani, Rajasthan 333031 (India); Purohit, L.P. [Department of Physics, Gurukul Kangri University, Haridwar 249404 (India); Sinha, A.K., E-mail: aksinha@ceeri.ernet.in [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute (CEERI), Council of Scientific and Industrial Research (CSIR), Pilani, Rajasthan 333031 (India)

2012-09-15

Highlights: Black-Right-Pointing-Pointer The complete electrical design of electron gun and interaction structure of double-beam gyrotron. Black-Right-Pointing-Pointer EGUN code is used for the simulation of electron gun of double-beam gyrotron. Black-Right-Pointing-Pointer MAGIC code is used for the simulation of interaction structure of double-beam gyrotron. Black-Right-Pointing-Pointer Design validations with other codes. - Abstract: This paper presents the numerical simulation of a double-beam magnetron injection gun (DB-MIG) and beam-wave interaction for 60 GHz, 500 kW gyrotron. The beam-wave interaction calculations, power and frequency growth estimation are performed by using PIC code MAGIC. The maximum output power of 510 kW at 41.5% efficiency, beam currents of 6 A and 12 A, electron beam velocity ratios of 1.41 and 1.25 and beam voltage of 69 kV are estimated. To obtain the design parameters, the DB-MIG with maximum transverse velocity spread less than 5% is designed. The computer simulations are performed by using the commercially available code EGUN and the in-house developed code MIGANS. The simulated results of DB-MIG design obtained by using the EGUN code are also validated with another trajectory code TRAK, which are in good agreement.

Control of the Superconducting Magnets current Power Supplies of the TJ-II Gyrotrons; Control de las Fuentes de Corriente de las Bobinas Superconductoras de los Girotrones del TJ-II

Energy Technology Data Exchange (ETDEWEB)

Ros, A; Fernandez, A; Tolkachev, A; Catalan, G

2006-07-01

The TJ-II ECRH heating system consists of two gyrotrons, which can deliver a maximum power of 300 kW at a frequency of 53.2 GHz. Another 28 GHz gyrotron is going to be used in the Bernstein waves heating system. In order to get the required frequency, the gyrotrons need and homogeneous magnetic field of several tesla, which is generated by a superconducting coil field by a current source. This document describes the current source control as well as the high precision ammeters control. These ammeters measure the current in the superconducting coils. The user interface and the programming of the control system are described. The communication between devices is also explained. (author) 9 Refs.

Study of a cylindrical cavity gyrotron, influence of power reflection and of the oscillation of a travelling mode

International Nuclear Information System (INIS)

Muggli, P.

1991-11-01

The quality factor and oscillating mode of a gyrotron cavity are essential parameters to consider when trying to obtain a high power (>500 kW), high efficiency (∼50%) microwave source, which oscillates in a stable manner in the principal mode of the cavity. The study and development of an 8 GHz gyrotron whose resonant cavity is formed by a cylindrical waveguide of slowly varying radius, is undertaken. The study is principally concerned with the phenomena associated with the low quality factor of the TE o 011 mode of the cavity. (author) figs., tabs., 102 refs

AN ANALYSIS OF THE ENVIRONMENTS OF FU ORIONIS OBJECTS WITH HERSCHEL

Energy Technology Data Exchange (ETDEWEB)

Green, Joel D.; Evans, Neal J. II; Merello, Manuel [Department of Astronomy, The University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, TX 78712-1205 (United States); Kospal, Agnes [European Space Agency (ESA/ESTEC), Keplerlaan 1, 2200-AG Noordwijk (Netherlands); Herczeg, Gregory [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Quanz, Sascha P. [Institute for Astronomy, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); Henning, Thomas; Bouwman, Jeroen [Max Planck Institute for Astronomy, Koenigstuhl 17, D-69117 Heidelberg (Germany); Van Kempen, Tim A. [Leiden Observatory, Leiden University, P.O. Box 9513, 2300-RA Leiden (Netherlands); Lee, Jeong-Eun [Department of Astronomy and Space Science, Kyung Hee University, Gyeonggi 446-701 (Korea, Republic of); Dunham, Michael M. [Department of Astronomy, Yale University, New Haven, CT (United States); Meeus, Gwendolyn [Departamento de Fisica Teorica, Universidad Autonoma de Madrid, Campus Cantoblanco (Spain); Chen, Jo-hsin [Jet Propulsion Laboratory, Pasadena, CA (United States); Guedel, Manuel; Liebhart, Armin [Department of Astrophysics, University of Vienna (Austria); Skinner, Stephen L., E-mail: joel@astro.as.utexas.edu [Center for Astrophysics and Space Astronomy (CASA), University of Colorado, Boulder, CO 80309-0389 (United States)

2013-08-01

We present Herschel-HIFI, SPIRE, and PACS 50-670 {mu}m imaging and spectroscopy of six FU Orionis-type objects and candidates (FU Orionis, V1735 Cyg, V1515 Cyg, V1057 Cyg, V1331 Cyg, and HBC 722), ranging in outburst date from 1936 to 2010, from the 'FOOSH' (FU Orionis Objects Surveyed with Herschel) program, as well as ancillary results from Spitzer Infrared Spectrograph and the Caltech Submillimeter Observatory. In their system properties (L{sub bol}, T{sub bol}, and line emission), we find that FUors are in a variety of evolutionary states. Additionally, some FUors have features of both Class I and II sources: warm continuum consistent with Class II sources, but rotational line emission typical of Class I, far higher than Class II sources of similar mass/luminosity. Combining several classification techniques, we find an evolutionary sequence consistent with previous mid-IR indicators. We detect [O I] in every source at luminosities consistent with Class 0/I protostars, much greater than in Class II disks. We detect transitions of {sup 13}CO (J{sub up} of 5-8) around two sources (V1735 Cyg and HBC 722) but attribute them to nearby protostars. Of the remaining sources, three (FU Ori, V1515 Cyg, and V1331 Cyg) exhibit only low-lying CO, but one (V1057 Cyg) shows CO up to J = 23 {yields} 22 and evidence for H{sub 2}O and OH emission, at strengths typical of protostars rather than T Tauri stars. Rotational temperatures for 'cool' CO components range from 20 to 81 K, for {approx} 10{sup 50} total CO molecules. We detect [C I] and [N II] primarily as diffuse emission.

Photonic-band-gap gyrotron amplifier with picosecond pulses

Science.gov (United States)

Nanni, Emilio A.; Jawla, Sudheer; Lewis, Samantha M.; Shapiro, Michael A.; Temkin, Richard J.

2017-12-01

We report the amplification of 250 GHz pulses as short as 260 ps without observation of pulse broadening using a photonic-band-gap circuit gyrotron traveling-wave-amplifier. The gyrotron amplifier operates with a device gain of 38 dB and an instantaneous bandwidth of 8 GHz. The operational bandwidth of the amplifier can be tuned over 16 GHz by adjusting the operating voltage of the electron beam and the magnetic field. The amplifier uses a 30 cm long photonic-band-gap interaction circuit to confine the desired TE03-like operating mode while suppressing lower order modes which can result in undesired oscillations. The circuit gain is >55 dB for a beam voltage of 23 kV and a current of 700 mA. These results demonstrate the wide bandwidths and a high gain achievable with gyrotron amplifiers. The amplification of picosecond pulses of variable lengths, 260-800 ps, shows good agreement with the theory using the coupled dispersion relation and the gain-spectrum of the amplifier as measured with quasi-CW input pulses.

Final Report for 'Gyrotron Design and Evaluation using New Particle-in-Cell Capability'

International Nuclear Information System (INIS)

Smithe, David N.

2008-01-01

ITER will depend on high power CW gyrotrons to deliver power to the plasma at ECR frequencies. However, gyrotrons can suffer from undesirable low frequency oscillations (LFO's) which are known to interfere with the gun-region diagnostics and data collection, and are also expected to produce undesirable energy and velocity spread in the beam. The origins and processes leading to these oscillations are poorly understood, and existing gyrotron R and D tools, such as static gun solvers and interaction region models, are not designed to look at time-dependant oscillatory behavior. We have applied a time-domain particle-in-cell method to investigate the LFO phenomenon. Our company is at the forefront of smooth-curved-boundary treatment of the electromagnetic fields and particle emission surfaces, and such methods are necessary to simulate the adiabatically trapped and reflected electrons thought to be driving the oscillations. This approach provides the means for understanding, in microscopic detail, the underlying physical processes driving the low-frequency oscillations. In the Phase I project, an electron gun region from an existing gyrotron, known to observe LFO's, was selected as a proof-of-principle geometry, and was modeled with the curved-geometry time-domain simulation tool, in order to establish the feasibility of simulating LFO physics with this tool on office-scale, and larger, parallel cluster computers. Generally, it was found to be feasible to model the simulation geometry, emission, and magnetic features of the electron gun. Ultimately, the tool will be used to investigate the origins and life cycle within the trapped particle population. This tool also provides the foundations and validation for potential application of the software to numerous other time-dependant beam and rf source problems in the commercial arena.

Development of steady-state 2 MW, 170 GHz gyrotrons for ITER

International Nuclear Information System (INIS)

Piosczyk, B.; Arnold, A.; Thumm, M.; Dammertz, G.; Heidinger, R.; Illy, S.; Jin, J.; Koppenburg, K.; Leonhardt, W.; Neffe, G.; Rzesnicki, T.; Schmid, M.; Yang, X.; Alberti, S.; Chavan, R.; Fasel, D.; Goodman, T.; Henderson, M.; Hogge, J.P.; Tran, M.Q.; Yovchev, I.; Erckmann, V.; Laqua, H.P.; Michel, G.; Gantenbein, G.; Kasparek, W.; Mueller, G.; Schwoerer, K.; Bariou, D.; Beunas, A.; Giguet, E.; LeCloarec, G.; Legrand, F.; Lievin, C.; Dumbrajs, O.

2005-01-01

A prototype of a 1 MW, CW, 140 GHz conventional gyrotron for the W7-X stellarator in Greifswald/Germany has been tested successfully and the fabrication of series tubes started. In extended studies the feasibility for manufacturing a continuously operated high power coaxial cavity gyrotron has been demonstrated and all needed data for an industrial design has been obtained. Based on this results the fabrication of a first prototype of a 2 MW, CW, 170 GHz coaxial cavity gyrotron started recently in cooperation between European research institutions and European tube industry. The prototype tube is foreseen to be tested in 2006 at CRPP Lausanne where a suitable test facility is under construction. (author)

Performance, diagnostics, controls and plans for the gyrotron system on the DIII-D tokamak

Directory of Open Access Journals (Sweden)

Ponce D.M.

2012-09-01

Full Text Available The DIII-D ECH complex is being upgraded with three new depressed collector gyrotrons. The performance of the existing system has been very good. As more gyrotrons having higher power are added to the system, diagnostics of gyrotron operation, optimization of the performance and qualification of components for higher power become more important. A new FPGA-based gyrotron control system is being installed, additional capabilities for rapid real time variation of the rf injection angles by the DIII-D Plasma Control System are being tested and infrastructure enhancements are being completed. Longer term plans continue to include ECH as a major component in the DIII-D heating and current drive capabilities.

Integrated Design of Undepressed Collector for Low Power Gyrotron

Science.gov (United States)

Kumar, Anil; Goswami, Uttam K.; Poonia, Sunita; Singh, Udaybir; Kumar, Nitin; Alaria, M. K.; Bera, A.; Khatun, Hasina; Sinha, A. K.

2011-06-01

A 42 GHz, 200 kW continuous wave (CW) gyrotron, operating at TE03 mode is under development for the electron cyclotron resonance plasma heating of the Indian TOKAMAK system. The gyrotron is made up of an undepressed collector. The undepressed collector is simple to design and cost effective. In this paper, a detailed design study of the undepressed collector for the 42 GHz gyrotron is presented. The EGUN code is used to analyze the spent electron beam trajectory for the maximum spread to reduce the power loading on the collector surface. To achieve wall loading ≤1 kW/cm2, a collector with a length of 800 mm and a radius of 42.5 mm is designed. The design also includes the three magnet systems around the collector for maximum and uniform beam spread. The thermal and the structural analyses are done using the ANSYS code to optimize the collector structure and dimensions with tolerance.

CONSTRAINING MASS RATIO AND EXTINCTION IN THE FU ORIONIS BINARY SYSTEM WITH INFRARED INTEGRAL FIELD SPECTROSCOPY

International Nuclear Information System (INIS)

Pueyo, Laurent; Hillenbrand, Lynne; Hinkley, Sasha; Dekany, Richard; Roberts, Jenny; Vasisht, Gautam; Roberts, Lewis C. Jr.; Shao, Mike; Burruss, Rick; Cady, Eric; Oppenheimer, Ben R.; Brenner, Douglas; Zimmerman, Neil; Monnier, John D.; Crepp, Justin; Parry, Ian; Beichman, Charles; Soummer, Rémi

2012-01-01

We report low-resolution near-infrared spectroscopic observations of the eruptive star FU Orionis using the Integral Field Spectrograph (IFS) Project 1640 installed at the Palomar Hale telescope. This work focuses on elucidating the nature of the faint source, located 0.''5 south of FU Ori, and identified in 2003 as FU Ori S. We first use our observations in conjunction with published data to demonstrate that the two stars are indeed physically associated and form a true binary pair. We then proceed to extract J- and H-band spectro-photometry using the damped LOCI algorithm, a reduction method tailored for high contrast science with IFS. This is the first communication reporting the high accuracy of this technique, pioneered by the Project 1640 team, on a faint astronomical source. We use our low-resolution near-infrared spectrum in conjunction with 10.2 μm interferometric data to constrain the infrared excess of FU Ori S. We then focus on estimating the bulk physical properties of FU Ori S. Our models lead to estimates of an object heavily reddened, A V = 8-12, with an effective temperature of ∼4000-6500 K. Finally, we put these results in the context of the FU Ori N-S system and argue that our analysis provides evidence that FU Ori S might be the more massive component of this binary system.

CONSTRAINING MASS RATIO AND EXTINCTION IN THE FU ORIONIS BINARY SYSTEM WITH INFRARED INTEGRAL FIELD SPECTROSCOPY

Energy Technology Data Exchange (ETDEWEB)

Pueyo, Laurent [Johns Hopkins University, Department of Physics and Astronomy, 366 Bloomberg Center 3400 N. Charles Street, Baltimore, MD 21218 (United States); Hillenbrand, Lynne; Hinkley, Sasha; Dekany, Richard; Roberts, Jenny [Department of Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Vasisht, Gautam; Roberts, Lewis C. Jr.; Shao, Mike; Burruss, Rick; Cady, Eric [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Oppenheimer, Ben R.; Brenner, Douglas; Zimmerman, Neil [American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024 (United States); Monnier, John D. [Department of Astronomy, University of Michigan, 941 Dennison Building, 500 Church Street, Ann Arbor, MI 48109-1090 (United States); Crepp, Justin [Department of Physics, 225 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556 (United States); Parry, Ian [University of Cambridge, Institute of Astronomy, Madingley Road, Cambridge, CB3, OHA (United Kingdom); Beichman, Charles [NASA Exoplanet Science Institute, 770 South Wilson Avenue, Pasadena, CA 91225 (United States); Soummer, Remi [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

2012-09-20

We report low-resolution near-infrared spectroscopic observations of the eruptive star FU Orionis using the Integral Field Spectrograph (IFS) Project 1640 installed at the Palomar Hale telescope. This work focuses on elucidating the nature of the faint source, located 0.''5 south of FU Ori, and identified in 2003 as FU Ori S. We first use our observations in conjunction with published data to demonstrate that the two stars are indeed physically associated and form a true binary pair. We then proceed to extract J- and H-band spectro-photometry using the damped LOCI algorithm, a reduction method tailored for high contrast science with IFS. This is the first communication reporting the high accuracy of this technique, pioneered by the Project 1640 team, on a faint astronomical source. We use our low-resolution near-infrared spectrum in conjunction with 10.2 {mu}m interferometric data to constrain the infrared excess of FU Ori S. We then focus on estimating the bulk physical properties of FU Ori S. Our models lead to estimates of an object heavily reddened, A{sub V} = 8-12, with an effective temperature of {approx}4000-6500 K. Finally, we put these results in the context of the FU Ori N-S system and argue that our analysis provides evidence that FU Ori S might be the more massive component of this binary system.

Weekly infusional high-dose fluorouracil (HD-FU), HD-FU plus folinic acid (HD-FU/FA), or HD-FU/FA plus biweekly cisplatin in advanced gastric cancer: randomized phase II trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie.

Science.gov (United States)

Lutz, Manfred P; Wilke, Hansjochen; Wagener, D J Theo; Vanhoefer, Udo; Jeziorski, Krzysztof; Hegewisch-Becker, Susanna; Balleisen, Leopold; Joossens, Eric; Jansen, Rob L; Debois, Muriel; Bethe, Ullrich; Praet, Michel; Wils, Jacques; Van Cutsem, Eric

2007-06-20

This multicentric, randomized, two-stage phase II trial evaluated three simplified weekly infusional regimens of fluorouracil (FU) or FU plus folinic acid (FA) and cisplatin (Cis) with the aim to select a regimen for future phase III trials. A total of 145 patients with advanced gastric cancer where randomly assigned to weekly FU 3,000 mg/m2/24 hours (HD-FU), FU 2,600 mg/m2/24 hours plus dl-FA 500 mg/m2 or l-FA 250 mg/m2 (HD-FU/FA), or FU 2000 mg/m2/24 hours plus FA plus biweekly Cis 50 mg/m2, each administered for 6 weeks with a 1-week rest. The primary end point was the response rate. Confirmed responses were observed in 6.1% (two of 33) of the eligible patients treated with HD-FU, in 25% (12 of 48, including one complete remission [CR]) with HD-FU/FA, and in 45.7% (21 of 46, including four CRs) with HD-FU/FA/Cis. The HD-FU arm was closed after stage 1 because the required minimum number of responses was not met. The median progression-free survival of all patients in the HD-FU, HD-FU/FA, and HD-FU/FA/Cis arm was 1.9, 4.0, and 6.1 months, respectively. The median overall survival was 7.1, 8.9, and 9.7 months, and the survival rate at 1 year was 24.3%, 30.3%, and 45.3%, respectively. Grade 4 toxicities were rare. The most relevant grade 3/4 toxicities were neutropenia in 1.9%, 5.4%, and 19.6%, and diarrhea in 2.7%, 1.9%, and 3.9% of the cycles in the HD-FU, HD-FU/FA, and HD-/FU/Cis arms, respectively. Weekly infusional FU/FA plus biweekly Cis is effective and safe in patients with gastric cancer.

Experimental results and recent developments on the EU 2 MW 170 GHz coaxial cavity gyrotron for ITER

Directory of Open Access Journals (Sweden)

Thumm M. K.

2012-09-01

Full Text Available The European Gyrotron Consortium (EGYC is responsible for developing one set of 170 GHz mm-wave sources, in support of Europe’s contribution to ITER. The original plan of targeting a 2 MW coaxial gyrotron is currently under discussion, in view of essential delays and damages. This paper reports on the latest results and plans with regard to the two 2 MW gyrotron prototypes, the industrial prototype at CRPP’s CW test stand and a modular pre-prototype at KIT. The industrial prototype was delivered to CRPP end of September 2011 and reached an output power of 2 MW at an efficiency of 45 % and with good RF beam pattern, in only four days of short pulse RF test. These results validated all design changes made in reaction to the results of the experiments in 2008. On the fifth experimental day, an internal absorber broke, terminating any further experiment with this tube. In parallel, design and experimental activities at KIT went on, in particular featuring reduced stray radiation down to 4% of the RF power. Next years’ plans for the 2 MW modular pre-prototype foresee a stepwise increase of pulse length.

High voltage K/sub a/-band gyrotron oscillator experiment

International Nuclear Information System (INIS)

Gold, S.H.; Fliflet, A.W.; Manheimer, W.M.; Black, W.M.; Granatstein, V.L.; Kinkead, A.K.; Hardesty, D.L.; Sucy, M.

1986-01-01

Future applications of millimeter-waves may require significantly higher powers (>100 MW) than are available from the long-pulse thermionic gyrotrons that are presently available or under development. Scaling studies suggest that these power levels should be accessible to gyrotrons employing relativistic (0.5-1 MeV), multi-kA electron beams, such as can be generated for short pulse lengths (≤100 nsec) using pulseline accelerators with plasma-induced field-emission cathodes. To explore this potential, the authors have assembled a new gyrotron experiment based on a compact Febetron pulser. Initial experiments using a 350keV, 700A electron beam with a ratio of transverse to longitudinal velocity of ≅0.75 have produced ≅20MW at 35GHz at 8.5% efficiency in a TE/sub 62/ mode, in good agreement with the predictions of theory for the experimental parameters. Substantially higher powers and efficiencies are predicted for a new experimental configuration, which will operate at a higher voltage with improved beam parameters. In this new experiment, a 600 keV, multi-kA electron beam will be produced with low initial transverse energy. Transverse kinetic energy will then be added to the beam either by resonant pumping, via a magnetic wiggler, or by transit through a nonadiabatic magnetic ''bump.'' Finally, the beam will be adiabatically compressed to the desired radius in the gyrotron cavity with a final α≅1. The authors plan to report on the latest results from this new experimental configuration

Soviet Development of Gyrotrons

Science.gov (United States)

1986-05-01

Relationship Type of Device Remarks V, - Vc, anomalous Doppler Capable of 100 percent efficiency, CRM but more cumbersome than Cheren- kov devices V...authors; and discusses inlividual Soviet reseaLc- groups, the basic organizational units responAiLle for the CRM and gyrotron research and development. The...maintained a cCnEistEnt iecord of significant achievements; it has managed to overcome the systenic yeaxness of the Soviet R&C systeg in teimg atle to

Gyrotron: an application of the relativistic bunching of electrons to the generation of intense millimeter microwave radiation

International Nuclear Information System (INIS)

Caplan, M.

1986-01-01

The cyclotron maser or gyrotron is capable of generating high power microwaves at millimeter wave frequencies for applications in fusion heating, radar astronomy and communications. Analytic and numerical simulation models are developed that describe the behavior of these devices under realistic laboratory conditions including the effects of circuit geometry, beam thermal spread, and mode competition. In Chapter 2, a generalized linear theory for the gyrotron is presented in the form of an integro-differential equation that can be solved within various circuit geometries thus describing gyro-amplifiers, gyro-oscillatory and gyroklystrons. In Chapter 3 a complete description of a finite size electromagnetic particle simulation model is presented that describes gyrotrons operating in a TE/sub mn/ waveguide mode. In Chapter 4 simulations and theoretical analysis are made of gyrotron amplifiers operating in the TE/sub 01/ mode. In Chapter 5 the linear eigenmodes and eigenfrequencies of gyrotron oscillators are examined. In Chapter 6 the experimental development of a GHz gyrotron is presented. Theoretical and numerical predictions of oscillation thresholds and efficiencies compare favorably with experimental data

Design of an electronically tunable millimeter wave Gyrotron Backward Wave Oscillator

International Nuclear Information System (INIS)

Caplan, M.

1987-01-01

A non-linear self-consistent computer simulation code is used to analyze the saturated output of the Gyrotron Backward Wave Oscillator (Gyro BWO) which can be used as a tunable driver for a 250 GHz FEL amplifier. Simulations show that the Gyrotron BWO using a Pierce/Wiggler gun configuration can produce at least 10 kW of microwave power over the range 249 GHz to 265 GHz by varying beam voltage alone

Development of collective Thomson scattering system using the gyrotrons of sub-tera Hz region

International Nuclear Information System (INIS)

Tatematsu, Y.; Kubo, S.; Nishiura, M.

2010-11-01

Collective Thomson scattering (CTS) system is being developed for fusion plasma and CTS measurement on the large helical device (LHD) plasma is discussed. Sub-terahertz frequencies are suitable to the probe beam for CTS on LHD. According to the feasibility study, frequency around 0.4 THz is best for the CTS measurement on LHD high density plasma, and power of 100 kW is required. Thus, only gyrotrons in the sub-terahertz range can meet these parameters. At the first stage of development, second harmonic gyrotrons have been developed. A sealed-off type of gyrotrons has been manufactured to improve a demountable one. Measured output power has increased to about 60 kW. In parallel with the development of gyrotrons, an actual CTS system using a 77 GHz gyrotron originally installed for heating is being developed as a benchmark of LHD CTS. A heterodyne receiver system of a fundamental mixer with a fixed frequency local oscillator was installed on the upstream of the transmission line. The probe beam is 100% power modulated at 50 Hz to separate the scattering component from background ECE. Signals that can be attributed to the CTS were obtained and the analysis method of these data is developed. (author)

Development of over 1 MW and multi-frequency gyrotrons for fusion

International Nuclear Information System (INIS)

Imai, T.; Kariya, T.; Minami, R.; Numakura, T.; Kato, T.; Endo, Y.; Ichimura, M.; Eguchi, T.; Mitsunaka, Y.; Shimozuma, T.; Kubo, S.; Takahashi, H.; Yoshimura, Y.; Igami, H.; Ito, S.; Mutoh, T.; Sakamoto, Keishi; Idei, H.; Zushi, H.; Nagasaki, K.; Sano, F.; Ono, M.

2014-10-01

The development of wide frequency range from 14 to 300 GHz of high power mega-watt gyrotron for fusion is in progress in University of Tsukuba. The strong development activity was carried out in collaboration with JAEA, NIFS, TETD and universities. Over-1 MW dual frequency gyrotron of new frequency range (14 – 35 GHz), where the reduction of diffraction loss and cathode optimization are quite important, has been developed for EC/EBW H and CD for GAMMA 10/PDX, QUEST, Heliotron J and NSTX-U. Output power of 1.25 MW at 28 GHz and estimated oscillation power of 1.2 MW at 35.45 GHz from the same tube have been achieved with the cathode angle improvement and two frequency window. This is the first demonstration of the over 1 MW dual-frequency operations in lower frequency, which contributes to the technology of wide band multi-frequency/multi-MW tube. The output power of 600 kW for 2 s at 28 GHz is also demonstrated. It is applied to the QUEST and has resulted higher EC-driven current than ever. As for higher frequency range, in the joint program of NIFS and Tsukuba for LHD ECH gyrotrons, a new frequency of 154 GHz has been successfully developed with a TE 28,8 cavity, which delivered 1.16 MW for 1 s and the total power of 4.4 MW to LHD plasma with other three 77 GHz tubes, which extended the LHD plasma to high T e region. All these gyrotron performances are new records in each frequency range. The sub-THz gyrotron development is also just begun in collaboration with JAEA for Demo-Reactor ECH system. (author)

Design of the all solid high-voltage power supply for a gyrotron body

Energy Technology Data Exchange (ETDEWEB)

Rao, Yihua [School of Mathematics and Physics, University of South China, Hengyang, 421001 (China); Chen, Wenguang, E-mail: 430000485393@usc.edu.cn [School of Electrical Engineering, University of South China, Hengyang, 421001 (China); Hu, Bo [School of Electrical Engineering, University of South China, Hengyang, 421001 (China); Rao, Jun; Huang, Mei; Kang, Zihua; Feng, Kun [Southwestern Institute of Physics, Chengdu, 610041 (China); Huang, Jiaqi [School of Electrical Engineering, University of South China, Hengyang, 421001 (China)

2017-04-15

Highlights: • Completed design of all solid-state high-voltage power supply for gyrotron body on HL-2M ECRH. • Consist of 58 PSM modules and one BUCK module, controlled by DSP system. • Fabricated full voltage 35 kV, 200 mA BPS and tested in dummy load. • The BPS can operate in three modes: single pulse mode, multi-pulse modulation mode and the six-level preset mode. - Abstract: Gyrotron plays an important role in the research of electron cyclotron resonance heating (ECRH) on Tokomak. The high-frequency switched power supply technology and pulse step modulation (PSM) technology are used in the development of the all solid high-voltage body power supply (BPS) for 1 MW/105 GHz Gyrotron on ECRH system. Firstly, the basic structure of the BPS and its control system are introduced. Secondly, the software control algorithm of voltage stabilization and modulate method are developed. Finally, the design is verified by the experiments. The experimental results of the single pulse mode, the multi-pulse modulation mode and the six-level preset mode, are shown. The output voltage of the power supply can reach 35 kV and the current at about 200 mA, which are adjustable in the full range. The maximum modulation frequency can reach 1 kHz and the front edge of the pulse can be adjust from 0 to 3 ms and the accuracy of the output voltage is less than 100 V. The results show that the control method is feasible and can be applied to other high power microwave sources.

A study of parametric instability in a harmonic gyrotron: Designs of third harmonic gyrotrons at 94 GHz and 210 GHz

International Nuclear Information System (INIS)

Saraph, G.P.; Antonsen, T.M. Jr.; Nusinovich, G.S.; Levush, B.

1995-01-01

Mode competition can present a major hurdle in achieving stable, efficient operation of a gyrotron at the cyclotron harmonics. A type of mode interaction in which three modes at different cyclotron harmonics are parametrically coupled together is analyzed here. This coupling can lead to parametric excitation or suppression of a mode; cyclic mode hopping; or the coexistence of three modes. Simulation results are presented for the parametric instability involving modes at the fundamental, second harmonic, and third harmonic of the cyclotron frequency. It is shown that the parametric excitation can lead to stable, efficient operation of a high-power gyrotron at the third harmonic. Based on this phenomenon, two practical designs are presented here for the third harmonic operation at 94 and 210 GHz. copyright 1995 American Institute of Physics

Cellular response to 5-fluorouracil (5-FU in 5-FU-resistant colon cancer cell lines during treatment and recovery

Directory of Open Access Journals (Sweden)

Kravik Katherine L

2006-05-01

Full Text Available Abstract Background Treatment of cells with the anti-cancer drug 5-fluorouracil (5-FU causes DNA damage, which in turn affects cell proliferation and survival. Two stable wild-type TP53 5-FU-resistant cell lines, ContinB and ContinD, generated from the HCT116 colon cancer cell line, demonstrate moderate and strong resistance to 5-FU, respectively, markedly-reduced levels of 5-FU-induced apoptosis, and alterations in expression levels of a number of key cell cycle- and apoptosis-regulatory genes as a result of resistance development. The aim of the present study was to determine potential differential responses to 8 and 24-hour 5-FU treatment in these resistant cell lines. We assessed levels of 5-FU uptake into DNA, cell cycle effects and apoptosis induction throughout treatment and recovery periods for each cell line, and alterations in expression levels of DNA damage response-, cell cycle- and apoptosis-regulatory genes in response to short-term drug exposure. Results 5-FU treatment for 24 hours resulted in S phase arrests, p53 accumulation, up-regulation of p53-target genes on DNA damage response (ATF3, GADD34, GADD45A, PCNA, cell cycle-regulatory (CDKN1A, and apoptosis-regulatory pathways (FAS, and apoptosis induction in the parental and resistant cell lines. Levels of 5-FU incorporation into DNA were similar for the cell lines. The pattern of cell cycle progression during recovery demonstrated consistently that the 5-FU-resistant cell lines had the smallest S phase fractions and the largest G2(/M fractions. The strongly 5-FU-resistant ContinD cell line had the smallest S phase arrests, the lowest CDKN1A levels, and the lowest levels of 5-FU-induced apoptosis throughout the treatment and recovery periods, and the fastest recovery of exponential growth (10 days compared to the other two cell lines. The moderately 5-FU-resistant ContinB cell line had comparatively lower apoptotic levels than the parental cells during treatment and recovery

Development of FuGO: An Ontology for Functional Genomics Investigations

Science.gov (United States)

Whetzel, Patricia L.; Brinkman, Ryan R.; Causton, Helen C.; Fan, Liju; Field, Dawn; Fostel, Jennifer; Fragoso, Gilberto; Gray, Tanya; Heiskanen, Mervi; Hernandez-Boussard, Tina; Morrison, Norman; Parkinson, Helen; Rocca-Serra, Philippe; Sansone, Susanna-Assunta; Schober, Daniel; Smith, Barry; Stevens, Robert; Stoeckert, Christian J.; Taylor, Chris; White, Joe; Wood, Andrew

2009-01-01

The development of the Functional Genomics Investigation Ontology (FuGO) is a collaborative, international effort that will provide a resource for annotating functional genomics investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. FuGO will contain both terms that are universal to all functional genomics investigations and those that are domain specific. In this way, the ontology will serve as the “semantic glue” to provide a common understanding of data from across these disparate data sources. In addition, FuGO will reference out to existing mature ontologies to avoid the need to duplicate these resources, and will do so in such a way as to enable their ease of use in annotation. This project is in the early stages of development; the paper will describe efforts to initiate the project, the scope and organization of the project, the work accomplished to date, and the challenges encountered, as well as future plans. PMID:16901226

High Power Microwave Emission of Large and Small Orbit Gyrotron Devices in Rectangular Interaction Structures

Science.gov (United States)

Hochman, J. M.; Gilgenbach, R. M.; Jaynes, R. L.; Rintamaki, J. I.; Luginsland, J. W.; Lau, Y. Y.; Spencer, T. A.

1996-11-01

Experiments utilize large and small orbit e-beam gyrotron devices in a rectangular-cross-section (RCS) gyrotron. This device is being explored to examine polarization control. Other research issues include pulse shortening, and mode competition. MELBA generates electron beams with parameters of: -800kV, 1-10kA diode current, and 0.5-1.0 μ sec pulselengths. The small orbit gyrotron device is converted to a large orbit experiment by running MELBA's annular electron beam through a magnetic cusp. Initial experiments showed an increase in beam alpha (V_perp/V_par) of a factor of ~ 4 between small and large orbit devices. Experimental results from the RCS gyrotron will be compared for large-orbit and small-orbit electron beams. Beam transport data and frequency measurements will be presented. Computer modeling utilizing the MAGIC and E-gun codes will be shown.

Numerical Simulation of MIG for 42 GHz, 200 kW Gyrotron

Science.gov (United States)

Singh, Udaybir; Bera, Anirban; Kumar, Narendra; Purohit, L. P.; Sinha, Ashok K.

2010-06-01

A triode type magnetron injection gun (MIG) of a 42 GHz, 200 kW gyrotron for an Indian TOKAMAK system is designed by using the commercially available code EGUN. The operating voltages of the modulating anode and the accelerating anode are 29 kV and 65 kV respectively. The operating mode of the gyrotron is TE03 and it is operated in fundamental harmonic. The simulated results of MIG obtained with the EGUN code are validated with another trajectory code TRAK.

Startup methods for single-mode gyrotron operation

International Nuclear Information System (INIS)

Whaley, D.R.; Tran, M.Q.; Alberti, S.; Tran, T.M.; Antonsen, T.M. Jr.; Dubrovin, A.; Tran, C.

1995-01-01

Experimental results of startup studies on a 118 GHz TE 22,6 gyrotron are presented and compared with theory. The startup paths through the energy-velocity-pitch-angle plane are determined by the time evolution of the beam parameters during the startup phase. These startup paths are modified by changing the anode and cathode voltage rise from zero to their nominal values and are seen to determine the cavity oscillating mode. Experimental results show specifically that competition between the TE 22,6 and TE -19,7 mode can be completely eliminated by use of the proper startup method in a case where a typical triode startup results in oscillation in the competing TE -19,7 mode. These new results are shown to be in excellent agreement with the theory whose approach is general and therefore applicable to gyrotrons operating in any arbitrary cavity mode. (author) 3 figs., 4 refs

Modelling, simulation and computer-aided design (CAD) of gyrotrons for novel applications in the high-power terahertz science and technologies

Science.gov (United States)

Sabchevski, S.; Idehara, T.; Damyanova, M.; Zhelyazkov, I.; Balabanova, E.; Vasileva, E.

2018-03-01

Gyrotrons are the most powerful sources of CW coherent radiation in the sub-THz and THz frequency bands. In recent years, they have demonstrated a remarkable potential for bridging the so-called THz-gap in the electromagnetic spectrum and opened the road to many novel applications of the terahertz waves. Among them are various advanced spectroscopic techniques (e.g., ESR and DNP-NMR), plasma physics and fusion research, materials processing and characterization, imaging and inspection, new medical technologies and biological studies. In this paper, we review briefly the current status of the research in this broad field and present our problem-oriented software packages developed recently for numerical analysis, computer-aided design (CAD) and optimization of gyrotrons.

Single-stage depressed collectors for gyrotrons

International Nuclear Information System (INIS)

Piosczyk, B.; Iatrou, C.T.; Dammertz, G.; Thumm, M.; Univ. Karlsruhe

1996-01-01

Two 140 GHz gyrotrons with a single-step depressed collector have been operated. The different position of the isolating collector gap in the stray magnetic field causes the electron motion in the retarding region to be in one case adiabatic and in the other case nonadiabatic. The kind of motion within the retarding field influences strongly the behavior of the gyrotron with a depressed collector. In the case of nonadiabatic motion a significant amount of transverse momentum is given to the electrons reflected at the collector potential. This causes the reflected electrons to be trapped between the magnetic mirror and the collector. The electrons escape from the trap by diffusion across the magnetic field to the body of the tube thus contributing to the body current. Despite the high body current there is no observable influence of the collector voltage on the RF output power. In the case of adiabatic motion the reflected electrons do not gain a sufficient amount of transverse momentum to be trapped by the magnetic mirror. They pass the cavity toward the gun and they are trapped between the negative gun potential and the collector. The interaction with the RF field by electrons traveling through the cavity enhances the diffusion in the velocity space thus enabling the trapped electrons to overcome the potential barrier and escape toward the collector. Therefore the body current stays at low values since in this case the reflected electrons do not contribute to it. However, at higher collector voltages a reduction of RF power occurred and some noise in the electron beam was observed. The main motivation for the development of gyrotrons in the frequency range above 100 GHz with power levels in excess of several hundreds kW per tube, is the application in magnetic fusion devices for plasma heating and for electron current drive

Quasi-optical gyrotron: present status and future prospect

International Nuclear Information System (INIS)

Tran, M.Q.

1989-01-01

A review of the main experiments on quasi-optical gyrotron is presented. Methods to improve the efficiency (pencil beam electron gun and depressed collector) will be discussed. (author) 5 figs., 1 tab., 10 refs

Upgrade of a 30 kV/10 mA anode power supply for triode type gyrotron

Energy Technology Data Exchange (ETDEWEB)

Siravo, Ugo, E-mail: ugo.siravo@epfl.ch; Alberti, Stefano; Dubray, Jérémie; Fasel, Damien; Hogge, Jean-Philippe; Marlétaz, Blaise; Marmillod, Philippe; Perez, Albert; Silva, Miguel

2015-10-15

Highlights: • Triode type gyrotron is fed by 3 power supplies: the main, an anode PS(APS) and a heater. • This paper presents the upgrade of 3APS, supplied in 1999, that never fulfilled the specs. • The new working principle is very efficient, easy to implement, for a minimal cost. • Upgraded APS provides extended modulation capabilities, no overshoot and lowerripple. • This upgrade will allow exploring new operation regimes for the 3 TCV X3 gyrotrons. - The RF power of a gyrotron with a triode type magnetron-injection-gun (MIG) can be directly controlled via the voltage applied between its anode and its cathode. Hence, the performance of this type of gyrotron relies directly on the possibilities offered by the power supply controlling the anode to cathode voltage. For a system of gyrotrons connected to the same main high-voltage power supply, with a triode MIG one has the additional advantage of independently controlling each individual gyrotron. This paper presents the modifications brought to the three existing 30 kV/10 mA anode power supplies connected to the 500 kW/118 GHz/2s X3 gyrotrons operated on the TCV Tokamak. The new working principle based on phase-shift modulation (PSM) is described in detail. Experimental results obtained on dummy load are compared to simulations performed during the design phase. With respect to the initial working principle, the modulation frequency capability has been increased by a factor 10 reaching more than 5 kHz, whereas the output voltage ripple as well as the overshoot/undershoot have been significantly reduced.

A 2 MW, 170 GHz coaxial cavity gyrotron - experimental verification of the design of main components

Energy Technology Data Exchange (ETDEWEB)

Piosczyk, B [Forschungszentrum Karlsruhe, Association EURATOM-FZK, Institut fuer Hochleistungsimpuls- und Mikrowellentechnik (IHM), Postfach 3640, D-76021 Karlsruhe (Germany); Dammertz, G [Forschungszentrum Karlsruhe, Association EURATOM-FZK, Institut fuer Hochleistungsimpuls- und Mikrowellentechnik (IHM), Postfach 3640, D-76021 Karlsruhe (Germany); Dumbrajs, O [Department of Engineering Physics and Mathematics, Helsinki University of Technology, Association EURATOM-TEKES, FIN-02150 Espoo (Finland)] (and others)

2005-01-01

A 2 MW, CW, 170 GHz coaxial cavity gyrotron is under development in cooperation between European Research Institutions (FZK Karlsruhe, CRPP Lausanne, HUT Helsinki) and the European tube industry (TED, Velizy, France). The design of critical components has recently been examined experimentally at FZK Karlsruhe with a short pulse ({approx} few ms) coaxial cavity gyrotron. This gyrotron uses the same cavity and the same quasioptical (q.o.) RF-output system as designed for the industrial prototype and a very similar electron gun.

Startup methods for single-mode gyrotron operation

International Nuclear Information System (INIS)

Whaley, D.R.; Tran, M.Q.; Alberti, S.; Tran, T.M.; Antonsen, T.M.; Tran, C.

1995-03-01

Experimental results of startup studies on a 118 GHz TE 22,6 gyrotron are presented and compared with theory. The theoretical excitation regimes of competing modes are computed in the energy-velocity-pitch-angle plane near the operation point. The startup paths through the plane are determined by the time evolution of the beam parameters during the startup phase. These startup paths are modified by changing the anode and cathode voltage rise from zero to their nominal values and are seen to determine the cavity oscillating mode. Experimental results show specifically that competition between the TE 22,6 and TE -19,7 mode can be completely eliminated by using the proper startup method in a case where a typical triode startup results in oscillation in the competing TE -19,7 mode. These new results are shown to be in excellent agreement with theory whose approach is general and therefore applicable to gyrotrons operating in any arbitrary cavity mode. (author) 5 figs., 1 tab., 13 refs

Simulation of Non-Uniform Electron Beams in the Gyrotron Electron-Optical System

Science.gov (United States)

Louksha, O. I.; Trofimov, P. A.

2018-04-01

New calculated data on the effect of emission inhomogeneities on the quality of the electron beam, which is formed in an electron-optical system of a gyrotron, have been obtained. The calculations were based on emission current density distributions, which were measured for the different cathodes in the gyrotron of Peter the Great St. Petersburg Polytechnic University. A satisfactory agreement between the experimental and calculated data on the influence of emission nonuniformities on the velocity spread of electrons has been shown. The necessity of considering the real distribution of the emission current density over the cathode surface to determine the main parameters of the electron beam—the velocity and energy spreads of the electrons, spatial structure of the beam, and coefficient of reflection of electrons from the magnetic mirror—has been demonstrated. The maximum level of emission inhomogeneities, which are permissible for effective work of gyrotrons, has been discussed.

Suppression and nonlinear excitation of parasitic modes in second harmonic gyrotrons operating in a very high order mode

International Nuclear Information System (INIS)

Nusinovich, Gregory S.; Pu, Ruifeng; Granatstein, Victor L.

2015-01-01

In recent years, there was an active development of high-power, sub-terahertz (sub-THz) gyrotrons for numerous applications. For example, a 0.67 THz gyrotron delivering more than 200 kW with about 20% efficiency was developed. This record high efficiency was achieved because the gyrotron operated in a high-order TE 31,8 -mode with the power of ohmic losses less than 10% of the power of outgoing radiation. That gyrotron operated at the fundamental cyclotron resonance, and a high magnetic field of about 27 T was created by a pulse solenoid. For numerous applications, it is beneficial to use gyrotrons at cyclotron harmonics which can operate in available cryomagnets with fields not exceeding 15 T. However, typically, the gyrotron operation at harmonics faces severe competition from parasitic modes at the fundamental resonance. In the present paper, we consider a similar 0.67 THz gyrotron designed for operation in the same TE 31,8 -mode, but at the second harmonic. We focus on two nonlinear effects typical for interaction between the fundamental and second harmonic modes, viz., the mode suppression and the nonlinear excitation of the mode at the fundamental harmonic by the second harmonic oscillations. Our study includes both the analytical theory and numerical simulations performed with the self-consistent code MAGY. The simulations show that stable second harmonic operation in the TE 31,8 mode is possible with only modest sacrifice of efficiency and power

Subterahertz gyrotron developments for collective Thomson scattering in LHDa)

Science.gov (United States)

Notake, T.; Saito, T.; Tatematsu, Y.; Kubo, S.; Shimozuma, T.; Tanaka, K.; Nishiura, M.; Fujii, A.; Agusu, La; Ogawa, I.; Idehara, T.

2008-10-01

Collective Thomson scattering (CTS) is expected to provide the spatially resolved velocity distribution functions of not only thermal and tail ions but also alpha particles resulting from fusion reactions. CTS using gyrotrons with frequency higher than the conventional ones used for plasma heating would have advantages to alleviate refraction, cutoff effects, and background electron cyclotron emission noise. Therefore, a high-power pulse gyrotron operating at approximately 400 GHz is being developed for CTS in Large Helical Device (LHD). A single-mode oscillation with a frequency greater than 400 GHz, applying the second-harmonic resonance, was successfully demonstrated in the first stage. At the same time, concrete feasibility study based on ray tracing, scattering spectra, and electron cyclotron emission calculations has been conducted.

110GHz-500kW long-pulse gyrotron with built-in quasi-optical mode converter

International Nuclear Information System (INIS)

Sakamoto, Keishi; Kariya, Tsuyoshi; Hayashi, Ken-ichi.

1994-01-01

We have designed, fabricated, and tested a 110 GHz-500 kW long-pulse gyrotron. The gyrotron incorporates a quasi-optical mode converter which transforms the oscillation mode, TE 22,2 , into a Gaussian radiation beam. The adoption of a built-in mode converter enabled us to design the electron beam collector so as to be capable of tolerating a 2 MW heat load. Attention was also paid to designing the gyrotron cavity and output window so as to permit long-pulse operations. In an experiment, we observed a maximum output power of 550 kW and achieved 1.3 s operation at a power level of 410 kW. (author)

FuNNy

DEFF Research Database (Denmark)

Madsen, Per Printz

2005-01-01

language, called FuNNy language) to C. The C learning library contains the learning algorithm. The generated C code is simple standard C and therefore it can be applied to all computers with a C-compiler. The learning algorithm is either a gradient descend method based on a numerical calculation...... of the gradient or a random search method. The input fuzzyfication can be described by four different kinds of membership functions. The output fuzzyfication is based on singletons. The rule base can be written in a natural language. The result of the learning is a new version of the fuzzy system described......The purpose of this paper is to describe a tool that is easy to use for implementing self learning fuzzy systems. This tool which is called FuNNy generates fuzzy systems. The tool consists of a compiler and a C learning library. The compiler translates a fuzzy system (written in a dedicated...

High-frequency gyrotrons and their application to tokamak plasma heating

International Nuclear Information System (INIS)

Kreischer, K.E.

1981-01-01

A comprehensive analysis of high frequency (100 to 200 GHz) and high power (> 100 kW) gyrotrons has been conducted. It is shown that high frequencies will be required in order for electron cyclotron radiation to propagate to the center of a compact tokamak power reactor. High power levels will be needed in order to ignite the plasma with a reasonable number of gyrotron units. In the first part of this research, a set of analytic expressions, valid for all TE cavity modes and all harmonics, is derived for the starting current and frequency detuning using the Vlasov-Maxwell equations in the weakly relativistic limit. The use of an optical cavity is also investigated

FuSuMaTech workshop

CERN Multimedia

Olofsson, Simon

2018-01-01

The goal of the FuSuMaTecH IP workshop, organised at CERN Ideaquare 19-20 April, was to educate superconductivity and magnet experts about intellectual property. About 30 participants from multiple institutes and companies worked together in this two day interactive program which was facilitated by CERN Knowledge Transfer. Great progress was made in shaping the FuSuMaTech industrial demonstrator projects as well as the R&D&I subjects.

FuGEFlow: data model and markup language for flow cytometry

Directory of Open Access Journals (Sweden)

Manion Frank J

2009-06-01

Full Text Available Abstract Background Flow cytometry technology is widely used in both health care and research. The rapid expansion of flow cytometry applications has outpaced the development of data storage and analysis tools. Collaborative efforts being taken to eliminate this gap include building common vocabularies and ontologies, designing generic data models, and defining data exchange formats. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt standard was recently adopted by the International Society for Advancement of Cytometry. This standard guides researchers on the information that should be included in peer reviewed publications, but it is insufficient for data exchange and integration between computational systems. The Functional Genomics Experiment (FuGE formalizes common aspects of comprehensive and high throughput experiments across different biological technologies. We have extended FuGE object model to accommodate flow cytometry data and metadata. Methods We used the MagicDraw modelling tool to design a UML model (Flow-OM according to the FuGE extension guidelines and the AndroMDA toolkit to transform the model to a markup language (Flow-ML. We mapped each MIFlowCyt term to either an existing FuGE class or to a new FuGEFlow class. The development environment was validated by comparing the official FuGE XSD to the schema we generated from the FuGE object model using our configuration. After the Flow-OM model was completed, the final version of the Flow-ML was generated and validated against an example MIFlowCyt compliant experiment description. Results The extension of FuGE for flow cytometry has resulted in a generic FuGE-compliant data model (FuGEFlow, which accommodates and links together all information required by MIFlowCyt. The FuGEFlow model can be used to build software and databases using FuGE software toolkits to facilitate automated exchange and manipulation of potentially large flow cytometry experimental data sets

FuGEFlow: data model and markup language for flow cytometry.

Science.gov (United States)

Qian, Yu; Tchuvatkina, Olga; Spidlen, Josef; Wilkinson, Peter; Gasparetto, Maura; Jones, Andrew R; Manion, Frank J; Scheuermann, Richard H; Sekaly, Rafick-Pierre; Brinkman, Ryan R

2009-06-16

Flow cytometry technology is widely used in both health care and research. The rapid expansion of flow cytometry applications has outpaced the development of data storage and analysis tools. Collaborative efforts being taken to eliminate this gap include building common vocabularies and ontologies, designing generic data models, and defining data exchange formats. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) standard was recently adopted by the International Society for Advancement of Cytometry. This standard guides researchers on the information that should be included in peer reviewed publications, but it is insufficient for data exchange and integration between computational systems. The Functional Genomics Experiment (FuGE) formalizes common aspects of comprehensive and high throughput experiments across different biological technologies. We have extended FuGE object model to accommodate flow cytometry data and metadata. We used the MagicDraw modelling tool to design a UML model (Flow-OM) according to the FuGE extension guidelines and the AndroMDA toolkit to transform the model to a markup language (Flow-ML). We mapped each MIFlowCyt term to either an existing FuGE class or to a new FuGEFlow class. The development environment was validated by comparing the official FuGE XSD to the schema we generated from the FuGE object model using our configuration. After the Flow-OM model was completed, the final version of the Flow-ML was generated and validated against an example MIFlowCyt compliant experiment description. The extension of FuGE for flow cytometry has resulted in a generic FuGE-compliant data model (FuGEFlow), which accommodates and links together all information required by MIFlowCyt. The FuGEFlow model can be used to build software and databases using FuGE software toolkits to facilitate automated exchange and manipulation of potentially large flow cytometry experimental data sets. Additional project documentation, including

Quasi-optical converters for high-power gyrotrons: a brief review of physical models, numerical methods and computer codes

International Nuclear Information System (INIS)

Sabchevski, S; Zhelyazkov, I; Benova, E; Atanassov, V; Dankov, P; Thumm, M; Arnold, A; Jin, J; Rzesnicki, T

2006-01-01

Quasi-optical (QO) mode converters are used to transform electromagnetic waves of complex structure and polarization generated in gyrotron cavities into a linearly polarized, Gaussian-like beam suitable for transmission. The efficiency of this conversion as well as the maintenance of low level of diffraction losses are crucial for the implementation of powerful gyrotrons as radiation sources for electron-cyclotron-resonance heating of fusion plasmas. The use of adequate physical models, efficient numerical schemes and up-to-date computer codes may provide the high accuracy necessary for the design and analysis of these devices. In this review, we briefly sketch the most commonly used QO converters, the mathematical base they have been treated on and the basic features of the numerical schemes used. Further on, we discuss the applicability of several commercially available and free software packages, their advantages and drawbacks, for solving QO related problems

Development of frequency step tunable 1 MW gyrotron at 131 to 146.5 GHz

Energy Technology Data Exchange (ETDEWEB)

Samartsev, A.; Gantenbein, G.; Dammertz, G.; Illy, S.; Kern, S.; Leonhardt, W.; Schlaich, A.; Schmid, M.; Thumm, M., E-mail: andrey.samartsev@kit.edu [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany)

2011-07-01

Effective control of power absorption in tokamaks and stellarators could be achieved by the frequency tuning of ECH and CD power delivered by high-power gyrotrons. In this report some results of the development of a frequency tunable gyrotron with fused-silica Brewster window are presented. Excitation of several modes at 1 MW power level in the range of frequencies from 131 to 146.5 GHz is achieved. (author)

The FU Orionis mechanism

International Nuclear Information System (INIS)

Larson, R.B.

1980-01-01

The large but temporary increase in radius accompanying the recurrent flare-ups of the FU Ori stars can be produced only by strong transient heating of a thin outer layer of the star. Simple composite polytropic models show that the observed changes in radius and luminosity can be accounted for if the outer 0.5 per cent of the mass gains a thermal energy comparable to the kinetic energy it would have in rapid rotation. The models also imply that the masses of the FU Ori stars are near 1 solar mass. The most plausible heating mechanism is an instability due to rapid rotation, and it is suggested that the secular instability of a convective rotating star to bar-like deformations is responsible; this will produce strong shocks, turbulence, and heating of the outermost layers of the star. Matter will also be ejected, and this could account for much of the mass and angular momentum lost from young stars. The most luminous T Tauri stars may have experienced recent FU Ori flare-ups and may still be a magnitude or more brighter than normal. (author)

High-harmonic relativistic gyrotron as an alternative to FEL

Energy Technology Data Exchange (ETDEWEB)

Bratman, V L; Kalynov, Yu K; Kolganov, N G; Manuilov, V N; Ofitserov, M M; Samsonov, S V; Volkov, A B [Russian Academy of Sciences, Nizhny Novgorod (Russian Federation). Inst. of Applid Physics

1997-12-31

A submillimeter wave gyrotron operating at moderately relativistic electron energies of 200-300 keV is proposed as a simple alternative to FEL. It is shown that high pulsed magnetic fields of 20-30 T and selective excitation of separate modes for resonances up to the 5-7 th harmonics will make it possible to obtain in a single device the coherent radiation with broadband frequency step tuning within the whole submillimeter wavelength range. At large pitch angles the coupling of the electron beam with cavity modes at higher harmonics should be as strong as at the fundamental one. In order to check the theoretical predictions, two gyrotrons were designed: LOG-1 (250 kV, 10 A, 10 ms) with a thermionic emission cathode and LOG-2 (350 kV, 35 A, 20 ns) with an explosive emission cathode. (J.U.). 7 refs.

Installation and operation of the 400 kW 140 GHz gyrotron on the MTX experiment

International Nuclear Information System (INIS)

Ferguson, S.W.; Felker, B.; Jackson, M.C.; Petersen, D.E.; Sewall, N.R.; Stever, R.D.

1991-09-01

This paper describes the installation and operation of the 400 kW 140 GHz gyrotron used for plasma heating on the Microwave Tokamak Experiment (MTX) at Lawrence Livermore National Laboratory (LLNL). The Varian VGT-8140 gyrotron has operated at a power level of 400 kW for 100 ms in conjunction with MTX plasma shots. The gyrotron system is comprised of a high voltage (-80 kV) modulated power supply, a multistation CAMAC computer control, a 5-tesla superconducting magnet, a series of conventional copper magnets, a circulating fluorinert (FC75) window cooling system, a circulating oil cooling system, a water cooling system, and microwave frequency and power diagnostics. Additionally, a Vlasov launcher is used to convert the gyrotron TE 15,2 mode to a Gaussian beam. Two versions of the Vlasov launcher have been used on the gyrotron, one version designed by LLNL and one version designed by the Japan Atomic Energy Research Institute (JAERI). The Gaussian beam from the Vlasov launcher is transported to the MTX tokamak by a series of 5 mirrors in a 35-meter-long, high-efficiency, quasioptical beam transport system. A twist polarizer is built into one of the mirrors to adjust for horizontal polarization in the tokamak. No windows are used between the Vlasov reflector and the MTX tokamak. A laser alignment system is used to perform the initial system alignment. A summary of the design and operating characteristics of each of these systems is included. Also included is a summary of the system operation and performance

The AKARI FU-HYU galaxy evolution program: first results from the GOODS-N field

Science.gov (United States)

Pearson, C. P.; Serjeant, S.; Negrello, M.; Takagi, T.; Jeong, W.-S.; Matsuhara, H.; Wada, T.; Oyabu, S.; Lee, H. M.; Im, M. S.

2010-05-01

The AKARI FU-HYU mission program carried out mid-infrared imaging of several well studied Spitzer fields preferentially selecting fields already rich in multi-wavelength data from radio to X-ray wavelengths filling in the wavelength desert between the Spitzer IRAC and MIPS bands. We present the initial results for the FU-HYU survey in the GOODS-N field. We utilize the supreme multiwavelength coverage in the GOODS-N field to produce a multiwavelength catalogue from infrared to ultraviolet wavelengths, containing more than 4393 sources, including photometric redshifts. Using the FU-HYU catalogue we present colour-colour diagrams that map the passage of PAH features through our observation bands. We find that the longer mid-infrared bands from AKARI (IRC-L18W 18 micron band) and Spitzer (MIPS24 24 micron band) provide an accurate measure of the total MIR emission of the sources and therefore their probable total mid-infrared luminosity. We also find that colours incorporating the AKARI IRC-S11 11 micron band produce a bimodal distribution where an excess at 11 microns preferentially selects moderate redshift star-forming galaxies. These powerful colour-colour diagnostics are further used as tools to extract anomalous colour populations, in particular a population of Silicate Break galaxies from the GOODS-N field showing that dusty starbursts can be selected of specific redshift ranges (z = 1.2-1.6) by mid-infrared drop-out techniques. The FU-HYU catalogue will be made publically available to the astronomical community.

Suppression criteria of parasitic mode oscillations in a gyrotron beam tunnel

Science.gov (United States)

Kumar, Nitin; Singh, Udaybir; Singh, T. P.; Sinha, A. K.

2011-02-01

This paper presents the design criteria of the parasitic mode oscillations suppression for a periodic, ceramic, and copper loaded gyrotron beam tunnel. In such a type of beam tunnel, the suppression of parasitic mode oscillations is an important design problem. A method of beam-wave coupling coefficient and its mathematical formulation are presented. The developed design criteria are used in the beam tunnel design of a 42 GHz gyrotron to be developed for the Indian TOKAMAK system. The role of the thickness and the radius of the beam tunnel copper rings to obtain the developed design criteria are also discussed. The commercially available electromagnetic code CST and the electron trajectory code EGUN are used for the simulations.

Suppression criteria of parasitic mode oscillations in a gyrotron beam tunnel

International Nuclear Information System (INIS)

Kumar, Nitin; Singh, Udaybir; Sinha, A. K.; Singh, T. P.

2011-01-01

This paper presents the design criteria of the parasitic mode oscillations suppression for a periodic, ceramic, and copper loaded gyrotron beam tunnel. In such a type of beam tunnel, the suppression of parasitic mode oscillations is an important design problem. A method of beam-wave coupling coefficient and its mathematical formulation are presented. The developed design criteria are used in the beam tunnel design of a 42 GHz gyrotron to be developed for the Indian TOKAMAK system. The role of the thickness and the radius of the beam tunnel copper rings to obtain the developed design criteria are also discussed. The commercially available electromagnetic code CST and the electron trajectory code EGUN are used for the simulations.

The first preliminary experiments on an 84 GHz gyrotron with a single-stage depressed collector

International Nuclear Information System (INIS)

Shimozuma, T.; Sato, M.; Takita, Y.

1997-10-01

We fabricated and tested an 84GHz gyrotron with a single-stage depressed collector. The gyrotron has a high-voltage insulating section made of a low loss silicon nitride composite. In this preliminary experiment in the depressed collector configuration, we obtained 591kW, 41% operation with a depression voltage of 22.5kV. Access to the higher efficiency region was inhibited by an increase in anode current. (author)

Health benefits of Kung Fu: a systematic review.

Science.gov (United States)

Tsang, Tracey Wai Man; Kohn, Michael; Chow, Chin Moi; Singh, Maria Fiatarone

2008-10-01

The Chinese martial arts (Kung Fu) have existed for centuries and are generally accepted as being beneficial for health without much empirical data. The aim of this systematic review was to assess the health effects of "hard" Kung Fu styles by performing electronic and manual searches of the literature. The aspects of health and the Kung Fu style examined varied between most studies; in some cases, the martial art group consisted of practitioners of other martial art styles also. Of 2103 references identified, only nine papers were eligible and reviewed. All were observational studies, observing a range of health aspects possibly related to Kung Fu training or performance. Our findings suggest that there is no evidence that Kung Fu practice is associated with the prevention or treatment of any health condition. However, as a moderate- to high-intensity form of aerobic exercise, it may confer benefits similar to those attributed to other aerobic training modalities. However, this hypothesis remains to be tested in clinical trials. Physiological benefits (e.g., aerobic capacity and bone density) may be associated with long-term Kung Fu practice. Future research in this area should adopt experimental designs, clearly identifying eligibility criteria, testing and training protocols, and include health-related outcomes and documentation of adverse events, to advance knowledge in this field.

Effects of electron beam parameters and velocity spread on radio frequency output of a photonic band gap cavity gyrotron oscillator

Energy Technology Data Exchange (ETDEWEB)

Singh, Ashutosh, E-mail: asingh.rs.ece@iitbhu.ac.in [Faculty of Physical Sciences, Institute of Natural Sciences and Humanities, Shri Ramswaroop Memorial University, Lucknow-Deva Road, Uttar Pradesh 225003 (India); Center of Research in Microwave Tubes, Department of Electronics Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005 (India); Jain, P. K. [Center of Research in Microwave Tubes, Department of Electronics Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005 (India)

2015-09-15

In this paper, the effects of electron beam parameters and velocity spread on the RF behavior of a metallic photonic band gap (PBG) cavity gyrotron operating at 35 GHz with TE{sub 041}–like mode have been theoretically demonstrated. PBG cavity is used here to achieve a single mode operation of the overmoded cavity. The nonlinear time-dependent multimode analysis has been used to observe the beam-wave interaction behavior of the PBG cavity gyrotron, and a commercially available PIC code “CST Particle Studio” has been reconfigured to obtain 3D simulation results in order to validate the analytical values. The output power for this typical PBG gyrotron has been obtained ∼108 kW with ∼15.5% efficiency in a well confined TE{sub 041}–like mode, while all other competing modes have significantly low values of power output. The output power and efficiency of a gyrotron depend highly on the electron beam parameters and velocity spread. The influence of several electron beam parameters, e.g., beam voltage, beam current, beam velocity pitch factor, and DC magnetic field, on the PBG gyrotron operations has been investigated. This study would be helpful in optimising the electron beam parameters and estimating accurate RF output power of the high frequency PBG cavity based gyrotron oscillators.

X-shooter spectroscopy of FU Tauri A

Science.gov (United States)

Stelzer, B.; Alcalá, J. M.; Scholz, A.; Natta, A.; Randich, S.; Covino, E.

2013-03-01

We have analyzed a broad-band optical and near-infrared spectrum of FU Tau A, which is a presumed young brown dwarf in the Taurus star forming region that has intrigued both theorists and observers by its overluminosity in the Hertzsprung-Russell (HR) diagram with respect to standard pre-main sequence evolutionary models. FU Tau A is brighter than any other Taurus member of the same or similar spectral type, and various phenomena (accretion, activity, binarity) have been put forth as possible explanations. The new data, obtained with the X-shooter spectrograph at the Very Large Telescope, include an unprecedented wealth of information on stellar parameters and simultaneously observed accretion and outflow indicators for FU Tau A. We present the first measurements of gravity (log g = 3.5 ± 0.5), radial velocity (RV = 22.5 ± 2.9 km s-1), rotational velocity (vsini = 20 ± 5 km s-1), and lithium equivalent width (EWLi = 430 ± 20 mÅ) for FU Tau A. From the rotational velocity and the published period we infer a disk inclination of i ≳ 50°. The lithium content is much lower than theoretically expected for such a young very low-mass object, adding another puzzling feature to this object's properties. We determine the mass accretion rate of FU Tau A from comparison of the luminosities of 20 emission lines to empirical calibrations from the literature and find a mean of log Ṁacc [M⊙/yr] = -9.9 with standard deviation σ = 0.2. The accretion rate determined independently from modeling of the excess emission in the Balmer and Paschen continua is consistent with this value. The corresponding accretion luminosity is too low to make a significant contribution to the bolometric luminosity. Strong magnetic activity affecting the stellar parameters or binarity of FU Tau A, both combined with extreme youth, may be responsible for its position in the HR diagram. The existence of an outflow in FU Tau A is demonstrated through the first detection of forbidden emission lines

Towards a 1 MW, 170 GHz gyrotron design for fusion application

Science.gov (United States)

Kumar, Anil; Kumar, Nitin; Singh, Udaybir; Bhattacharya, Ranajoy; Yadav, Vivek; Sinha, A. K.

2013-03-01

The electrical design of different components of 1 MW, 170 GHz gyrotron such as, magnetron injection gun, cylindrical interaction cavity and collector and RF window is presented in this article. Recently, a new project related to the development of 170 GHz, 1 MW gyrotron has been started for the Indian Tokamak. TE34,10 mode is selected as the operating mode after studied the problem of mode competition. The triode type geometry is selected for the design of magnetron injection gun (MIG) to achieve the required beam parameters. The maximum transverse velocity spread of 3.28% at the velocity ratio of 1.34 is obtained in simulations for a 40 A, 80 kV electron beam. The RF output power of more than 1 MW with 36.5% interaction efficiency without depressed collector is predicted by simulation in single-mode operation at 170 GHz frequency. The simulated single-stage depressed collector of the gyrotron predicted the overall device efficiencies >55%. Due to the very good thermal conductivity and very weak dependency of the dielectric parameters on temperature, PACVD diamond is selected for window design for the transmission of RF power. The in-house developed code MIGSYN and GCOMS are used for initial geometry design of MIG and mode selection respectively. Commercially available simulation tools MAGIC and ANSYS are used for beam-wave interaction and mechanical analysis respectively.

Numerical design and analysis of parasitic mode oscillations for 95 GHz gyrotron beam tunnel

Science.gov (United States)

Kumar, Nitin; Singh, Udaybir; Yadav, Vivek; Kumar, Anil; Sinha, A. K.

2013-05-01

The beam tunnel, equipped with the high lossy ceramics, is designed for 95 GHz gyrotron. The geometry of the beam tunnel is optimized considering the maximum RF absorption (ideally 100%) and the suppression of parasitic oscillations. The excitation of parasitic modes is a concerning problem for high frequency, high power gyrotrons. Considering the problem of parasitic mode excitation in beam tunnel, a detail analysis is performed for the suppression of these kinds of modes. Trajectory code EGUN and CST Microwave Studio are used for the simulations of electron beam trajectory and electromagnetic analysis, respectively.

- In vivo monitoring of 5-FU

OpenAIRE

Lucas, Susanne

2010-01-01

The aim of the present study was to establish the in vivo-monitoring of the enrichment of 5-FU liposomes in liver and liver metastases by MRI methods. Relative signal intensities of liver and tumor tissue were determined. After sacrifying animals concentrations of 5-FU and it´s active intracellular metabolite M3 were measured by HPLC techniques. We used CC531 adenocarcinoma in the liver of WAG/Rij rats as a standardized liver tumor model in our investigatio...

Feasibility of a dual regime gyrotron

International Nuclear Information System (INIS)

Sawant, Ashwini; Jain, Prerit; Kartikeyan, M.V.

2012-01-01

The design concept of a 42/84 GHz, 500 kW, CW, dual-regime gyrotron for ECRH of plasma in an experimental Tokamak will be presented in this paper. Operation at 42 GHz is fundamental where as that in 84 GHz will be second harmonic so that a similar guidance system will be retained for dual regime operation. In this paper, the mode competition and mode selection procedures are presented for such a dual regime operation. Cold cavity design and self-consistent calculations will be carried out for power and efficiencies. (author)

Design and experimental investigation of a second harmonic 20 kW class 28 GHz gyrotron for evaluation of new emitter technologies

Energy Technology Data Exchange (ETDEWEB)

Malygin, Anton

2016-07-01

Gyrotrons are high-power mm-wave tubes. Here, the design, construction and experimental investigation of a 20 kW, 28 GHz gyrotron (2nd harmonic) are reported. This tube was designed to evaluate new emitters for future highly efficient and reliable fusion gyrotrons and for material processing applications. Following experimental results have been achieved in CW operation: 22.5 kW output power at 23.4 kV electron beam voltage and 2.23 A beam current with the world record efficiency of 43 %.

Intense high-frequency gyrotron-based microwave beams for material processing

Energy Technology Data Exchange (ETDEWEB)

Hardek, T.W.; Cooke, W.D.; Katz, J.D.; Perry, W.L.; Rees, D.E.

1997-03-01

Microwave processing of materials has traditionally utilized frequencies in the 0.915 and 2.45 GHz regions. Microwave power sources are readily available at these frequencies but the relatively long wavelengths can present challenges in uniformly heating materials. An additional difficulty is the poor coupling of ceramic based materials to the microwave energy. Los Alamos National Laboratory scientists, working in conjunction with the National Center for Manufacturing Sciences (NCMS), have assembled a high-frequency demonstration processing facility utilizing gyrotron based RF sources. The facility is primarily intended to demonstrate the unique features available at frequencies as high as 84 GHz. The authors can readily provide quasi-optical, 37 GHz beams at continuous wave (CW) power levels in the 10 kW range. They have also provided beams at 84 GHz at 10 kW CW power levels. They are presently preparing a facility to demonstrate the sintering of ceramics at 30 GHz. This paper presents an overview of the present demonstration processing facility and describes some of the features they have available now and will have available in the near future.

THE NATURE AND EVOLUTIONARY STATE OF THE FU ORIONIS BINARY SYSTEM

Energy Technology Data Exchange (ETDEWEB)

Beck, Tracy L. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Aspin, C., E-mail: tbeck@stsci.edu, E-mail: caa@ifa.hawaii.edu [Institute for Astronomy, University of Hawaii, 640 North Aohoku Place, Hilo, HI 96720 (United States)

2012-03-15

In this paper, we present the results of our adaptive optics fed three-dimensional imaging spectroscopy study of the FU Orionis binary system. Although the 0.''5 separation companion to FU Ori is {approx}4 mag fainter, we have easily spatially resolved it in the J, H, and K infrared bands and extract high signal-to-noise spectra of the two stellar components from 1.15 to 2.4 {mu}m. We derive a spectral type of K5{sup +2}{sub -1} for FU Ori S based on the stellar photospheric absorption features and find that it is an actively accreting young star (M-dot{sub acc}{approx} (2-3) Multiplication-Sign 10{sup -8} M{sub Sun} yr{sup -1}) that is likely gravitationally bound to FU Ori. We have found that the continuum shape of FU Ori S is not well fit by our spectral modeling process, and this results in a large uncertainty in the line-of-sight extinction to the star. Yet, by placing FU Ori S on the Hertzsprung-Russell diagram and comparing its estimated location with evolutionary models, we find that it is best fit as a {approx}1.2 M{sub Sun} star with a likely age of less than {approx}2 Myr. If we assume coevality of the stellar components, we have thus placed an estimated age on the FU Ori system. Moreover, assuming the canonical model for the nature of FU Ori in that its optical and infrared absorption features arise primarily from the inner circumstellar disk around a {approx}0.3 M{sub Sun} star, we find that the fainter FU Ori S component is actually the more massive star in the system. Future monitoring of FU Ori S to investigate flux variability and orbital motion should further clarify the nature of this curious young binary.

New design for the anode power supply of a gyrotron

International Nuclear Information System (INIS)

Fasel, D.; Alberti, S.; Favre, A.; Perez, A.; Acero, J.; Ganuza, D.; Garcia, I.; Lucia, C.

1998-01-01

The introduction will remind the main supply structure installed in the CRPP, related to the ECRH (Electron Cyclotron Resonance Heating) project on the TCV (Tokamak Configuration Variable) tokamak. Then this paper concentrates on the description of the power source designed to supply the anode of the triode type gyrotron. First the requirements asked for this power supply will be presented, taking into account the possible feeding structures in relation with the existing HV DC cathode power supply. The following section will focus on the selected design, describing in details the power structure based on MOSFET, referred to the cathode potential. Afterwards the control electronics is presented, including the feedback control implemented, the HV measurements, the internal reference generator and the interface to the TCV control. Finally, the last section will give information on the project status. (author)

Design of test JIG for centralized interlock and protection module of ITER-India Gyrotron Test Facility

International Nuclear Information System (INIS)

Rathod, Vipal; Rao, S.L.; Edappala, Praveenlal; Rajpal, Rachana

2017-01-01

Fast Interlock and protection system plays very crucial role in ensuring the safe and reliable operation of high power RF sources such as a Gyrotron system. Critical Protection Interlocks are generally implemented using hardwired components and are required to have a response time as fast as < 10 μs. In this context, an Industrial grade prototype Centralized Interlock and Protection Module (CIM) based on ITER-India design has been developed successfully with the help of local industry. This paper presents the complete requirements, approach, detailed design concept and current status of Test JIG in detail

Interpretation of the nonlinear mode excitation in the ITER gyrotron

International Nuclear Information System (INIS)

Nusinovich, G. S.; Sinitsyn, O. V.

2007-01-01

This study was motivated by an interesting physical effect observed in experiments with a 1 MW, 170 GHz, continuous-wave gyrotron developed at the Japan Atomic Energy Agency for plasma heating and current drive in ITER [see, e.g., Fusion Eng. Des. 55, issues 2-3 (2001)]. In these experiments, the gyrotron switching from a parasitic mode to the operating one was observed with the increase in external magnetic field in the region of hard self-excitation of the operating mode where it cannot be excited from the noise level in the absence of other modes. Below, the theory describing this effect is developed. The switching mechanism caused by merging and disappearance of two (one stable and another unstable) equilibrium states with nonzero amplitudes of both modes is proposed. It is found that the present theory can correctly interpret experimental results qualitatively, but the lack of experimental data does not let the authors carry out some simulations more adequate to experimental conditions

Stability analysis of a coaxial-waveguide gyrotron traveling-wave amplifier

International Nuclear Information System (INIS)

Hung, C.L.; Yeh, Y.S.

2005-01-01

The gyrotron traveling-wave tube (gyro-TWT) amplifier is known to be highly susceptible to spurious oscillations. This study develops a simulation approach to analyze the stability of a coaxial-waveguide gyro-TWT with distributed wall losses. The interplay among the absolute instabilities, the gyrotron backward-wave oscillations, and the circuit parameters is analyzed. Simulation results reveal that the distributed wall losses effectively stabilize spurious oscillations in the coaxial gyro-TWT. Furthermore, the wall resistivity of the center conductor is shown to be an additional effective mechanism for suppressing oscillations. Under stable operation conditions, the coaxial gyro-TWT with distributed losses is predicted to generate 435 kW in the Ka band with 31% efficiency, a saturated gain of 45 dB, and a bandwidth of 1.86 GHz (≅5.8%) for a 70 kV, 20 A electron beam with an α(=ν perpendicular )/ν z )=1.0 and an axial velocity spread of Δν z /ν z =5%

Weekly infusional high-dose fluorouracil (HD-FU), HD-FU plus folinic acid (HD-FU/FA), or HD-FU/FA plus biweekly cisplatin in advanced gastric cancer: randomized phase II trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie.

NARCIS (Netherlands)

Lutz, M.P.; Wilke, H.; Wagener, D.J.T.; Vanhoefer, U.; Jeziorski, K.; Hegewisch-Becker, S.; Balleisen, L.; Joossens, E.; Jansen, R.L.; Debois, M.; Bethe, U.; Praet, M.; Wils, J.; Cutsem, E. van

2007-01-01

PURPOSE: This multicentric, randomized, two-stage phase II trial evaluated three simplified weekly infusional regimens of fluorouracil (FU) or FU plus folinic acid (FA) and cisplatin (Cis) with the aim to select a regimen for future phase III trials. PATIENTS AND METHODS: A total of 145 patients

High-power and long-pulse operation of TE{sub 31,11} mode gyrotron

Energy Technology Data Exchange (ETDEWEB)

Ikeda, Ryosuke, E-mail: ikeda.ryosuke@jaea.go.jp; Kajiwara, Ken; Oda, Yasuhisa; Takahashi, Koji; Sakamoto, Keishi

2015-10-15

Highlights: • We are under development of TE{sub 31,11} mode gyrotron to aim ITER specification. • HE{sub 11} mode purity reached 96% of ITER specification. • Mode competition was suppressed in initial phase of oscillation by anode voltage control. • Maximum output power of 1.2 MW was achieved. • Steady state operation of 500 MJ was achieved. - Abstract: The ITER electron cyclotron system is designed to inject a 20 MW RF beam by using twenty-four 170 GHz/1 MW gyrotrons. JAEA is currently developing a gyrotron having a high-order mode (TE{sub 31,11}) to reduce the heat load in the cavity resonator and achieve an output power greater than 1 MW. The measured radiation profile at the front of the diamond window agreed with the results of the calculation. In order to suppress RF loss in the equatorial and upper port launchers, a high-quality HE{sub 11} mode is required at the exit of the matching optics unit (MOU). An HE{sub 11} mode purity of 96% was achieved by finely adjusting the two mirrors in the MOU. During the oscillation start-up phase, mode competition with counter-rotating TE{sub 29,12} mode was observed on the higher magnetic field side which caused arcing and pressure increase in the gyrotron. To avoid the counter-rotating TE{sub 29,12} mode from being excited, a start-up scenario that controls the voltage between the anode and cathode electrodes at the initial phase of operation was introduced, which was able to achieve a stable start-up of TE{sub 31,11} mode. A 1.2 MW output power having a total electric efficiency of 43% was obtained in high-power experiments. In steady-state operation, a 1000 s oscillation length and output power of 0.51 MW was achieved.

Design, Development & Functional Validation of Magnets system in support of 42 GHz Gyrotron in India

Directory of Open Access Journals (Sweden)

Pradhan S.

2017-01-01

Full Text Available A multi institutional initiative is underway towards the development of 42 GHz, 200 kW gyrotron system in India under the frame work of Department of Science and Technology, Government of India. Indigenous realization comprising of design, fabrication, prototypes and functional validations of an appropriate Magnet System is one of the primary technological objective of these initiatives. The 42 GHz gyrotron magnet system comprises of a warm gun magnet, a NbTi/Cu based high homogenous superconducting cavity magnet and three warm collector magnets. The superconducting cavity magnet has been housed inside a low loss cryostat. The magnet system has been designed in accordance with gyrotron physics and engineering considerations respecting highly homogenous spatial field profile as well as maintaining steep gradient as per the compression and velocity ratios between the emission and resonator regions. The designed magnet system further ensures the co-linearity of the magnetic axis with that of the beam axis with custom winding techniques apart from a smooth collection of beam with the collector magnet profiles. The designed magnets have been wound after several R & D validations. The superconducting magnet has been housed inside a low loss designed cryostat with in-built radial and axial alignment flexibilities to certain extent. The cryostat further houses liquid helium port, liquid nitrogen ports, current communication ports, ports for monitoring helium level and other instrumentations apart from over-pressure safety intensive burst disks etc. The entire magnet system comprising of warm and superconducting magnets has been installed and integrated in the Gyrotron test set-up. The magnet system has been aligned in both warm and when the superconducting cavity magnet is cold. The integrated geometric axes have been experimentally ensured as well as the field profiles have been measured with the magnets being charged. Under experimental conditions

A high-order particle-in-cell method for low density plasma flow and the simulation of gyrotron resonator devices

International Nuclear Information System (INIS)

Stock, Andreas

2013-01-01

Within this thesis a parallelized, transient, three-dimensional, high-order discontinuous Galerkin Particle-in-Cell solver is developed and used to simulate the resonant cavity of a gyrotron. The high-order discontinuous Galerkin approach - a Finite-Element type method - provides a fast and efficient algorithm to numerically solve Maxwell's equations used within this thesis. Besides its outstanding dissipation and dispersion properties, the discontinuous Galerkin approach easily allows for using unstructured grids, as required to simulate complex-shaped engineering devices. The discontinuous Galerkin approach approximates a wavelength with significantly less degrees of freedom compared to other methods, e.g. Finite Difference methods. Furthermore, the parallelization capabilities of the discontinuous Galerkin framework are excellent due to the very local dependencies between the elements. These properties are essential for the efficient numerical treatment of the Vlasov-Maxwell system with the Particle-in-Cell method. This system describes the self-consistent interaction of charged particles and the electromagnetic field. As central application within this thesis gyrotron resonators are simulated with the discontinuous Galerkin Particle-in-Cell method on high-performance-computers. The gyrotron is a high-power millimeter wave source, used for the electron cyclotron resonance heating of magnetically confined fusion plasma, e.g. in the Wendelstein 7-X experimental fusion-reactor. Compared to state-of-the-art simulation tools used for the design of gyrotron resonators the Particle-in-Cell method does not use any significant physically simplifications w.r.t. the modelling of the particle-field-interaction, the geometry and the wave-spectrum. Hence, it is the method of choice for validation of current simulation tools being restricted by these simplifications. So far, the Particle-in-Cell method was restricted to be used for demonstration calculations only, because

A high-order particle-in-cell method for low density plasma flow and the simulation of gyrotron resonator devices

Energy Technology Data Exchange (ETDEWEB)

Stock, Andreas

2013-04-26

Within this thesis a parallelized, transient, three-dimensional, high-order discontinuous Galerkin Particle-in-Cell solver is developed and used to simulate the resonant cavity of a gyrotron. The high-order discontinuous Galerkin approach - a Finite-Element type method - provides a fast and efficient algorithm to numerically solve Maxwell's equations used within this thesis. Besides its outstanding dissipation and dispersion properties, the discontinuous Galerkin approach easily allows for using unstructured grids, as required to simulate complex-shaped engineering devices. The discontinuous Galerkin approach approximates a wavelength with significantly less degrees of freedom compared to other methods, e.g. Finite Difference methods. Furthermore, the parallelization capabilities of the discontinuous Galerkin framework are excellent due to the very local dependencies between the elements. These properties are essential for the efficient numerical treatment of the Vlasov-Maxwell system with the Particle-in-Cell method. This system describes the self-consistent interaction of charged particles and the electromagnetic field. As central application within this thesis gyrotron resonators are simulated with the discontinuous Galerkin Particle-in-Cell method on high-performance-computers. The gyrotron is a high-power millimeter wave source, used for the electron cyclotron resonance heating of magnetically confined fusion plasma, e.g. in the Wendelstein 7-X experimental fusion-reactor. Compared to state-of-the-art simulation tools used for the design of gyrotron resonators the Particle-in-Cell method does not use any significant physically simplifications w.r.t. the modelling of the particle-field-interaction, the geometry and the wave-spectrum. Hence, it is the method of choice for validation of current simulation tools being restricted by these simplifications. So far, the Particle-in-Cell method was restricted to be used for demonstration calculations only, because

Update on the DIII-D ECH system: experiments, gyrotrons, advanced diagnostics, and controls

Directory of Open Access Journals (Sweden)

Lohr John

2017-01-01

Full Text Available The ECH system on DIII-D is continuing to be upgraded, while simultaneously being operated nearly daily for plasma experiments. The latest major hardware addition is a new 117.5 GHz gyrotron, which generated 1.7 MW for short pulses during factory testing. A new gyrotron control system based on Field Programmable Gate Array (FPGA technology with very high speed system data acquisition has significantly increased the flexibility and reliability of individual gyrotron operation. We have improved the performance of the fast mirror scanning, both by increasing the scan speeds and by adding new algorithms for controlling the aiming using commands generated by the Plasma Control System (PCS. The system is used for transport studies, ELM control, current profile control, non-inductive current generation, suppression of MHD modes, startup assist, plasma density control, and other applications. A program of protective measures, which has been in place for more than two years, has eliminated damage to hardware and diagnostics caused by overdense operation. Other activities not directly related to fusion research have used the ECH system to test components, study methods for improving production of semiconductor junctions and materials, and test the feasibility of using ground based microwave systems to power satellites into orbit.

Update on the DIII-D ECH system: experiments, gyrotrons, advanced diagnostics, and controls

Science.gov (United States)

Lohr, John; Brambila, Rigoberto; Cengher, Mirela; Gorelov, Yuri; Grosnickle, William; Moeller, Charles; Ponce, Dan; Torrezan, Antonio; Ives, Lawrence; Reed, Michael; Blank, Monica; Felch, Kevin; Parisuaña, Claudia; LeViness, Alexandra

2017-08-01

The ECH system on DIII-D is continuing to be upgraded, while simultaneously being operated nearly daily for plasma experiments. The latest major hardware addition is a new 117.5 GHz gyrotron, which generated 1.7 MW for short pulses during factory testing. A new gyrotron control system based on Field Programmable Gate Array (FPGA) technology with very high speed system data acquisition has significantly increased the flexibility and reliability of individual gyrotron operation. We have improved the performance of the fast mirror scanning, both by increasing the scan speeds and by adding new algorithms for controlling the aiming using commands generated by the Plasma Control System (PCS). The system is used for transport studies, ELM control, current profile control, non-inductive current generation, suppression of MHD modes, startup assist, plasma density control, and other applications. A program of protective measures, which has been in place for more than two years, has eliminated damage to hardware and diagnostics caused by overdense operation. Other activities not directly related to fusion research have used the ECH system to test components, study methods for improving production of semiconductor junctions and materials, and test the feasibility of using ground based microwave systems to power satellites into orbit.

Development and simulation of RF components for high power millimeter wave gyrotrons

Energy Technology Data Exchange (ETDEWEB)

Pereyaslavets, M.; Sato, M.; Shimozuma, T.; Takita, Y.; Idei, H.; Kubo, S.; Ohkubo, K.; Hayashi, K.

1996-11-01

To test gyrotron RF components, efficient low-power generators for rotating high-order modes of high purity are necessary. Designs of generators for the TE{sub 15,3} mode at 84 GHz and for the TE{sub 31,8} mode at 168 GHz are presented and some preliminary test results are discussed. In addition, Toshiba gyrotron cavities at 168 GHz were analyzed for leakage of RF power in the beam tunnel. To decrease RF power leakage, the declination angle of the cut-off cavity cross section has to be decreased. A TE{sub 15,3} waveguide nonlinear uptaper is analyzed at 84 GHz as well as 168 GHz uptapers. Since the calculated conversion losses are slightly higher than designed value, an optimization of those uptapers may be required. (author)

Feasibility study of the EU home team on a 170 GHz 1 MW CW gyrotron for ECH on ITER

International Nuclear Information System (INIS)

Iatrou, C.T.; Kern, S.; Thumm, M.; Moebius, A.; Nickel, H.U.; Horajitra, P.; Wien, A.; Tran, T.M.; Bon Mardion, G.; Pain, M.; Tonon, G.

1995-03-01

The gyrotron system for ECH and burn control on ITER requires at least 50 MW of RF power at frequencies near 170 GHz operating in CW. To meet these requirements, high efficiency gyrotron tubes with ≥1 MW power output capability are necessary, as well as simple coupling to either a quasi-optical or waveguide transmission line. The paper reports the feasibility study on the design of an ITER-relevant gyrotron oscillator at 170 GHz, 1 MW CW employing a diode electron gun, an advanced internal quasi-optical converter, a cryogenically cooled single disk sapphire window, and a depressed potential collector. The operating mode selection and the cavity design is a compromise between many design constraints. (author) 18 figs., 6 tabs., 21 refs

Control of generation spectrum of gyrotron with external reflection in mode of several longitudinal modes

International Nuclear Information System (INIS)

Rozental', R.M.; Ginzburg, N.S.; Zajtsev, N.I.; Ilyakov, E.V.; Kulagin, I.S.

2006-01-01

One studies possibility to control the spectrum of multiparticle generation in a gyrotron due to application of external reflections. It is shown that in self-modulation regimes of generation the radiation spectrum lines may be close to the resonance frequencies throughout electrodynamic system covering a part of output waveguide restricted by a reflector. Under the mentioned conditions variation of distance between mode frequencies and, respectively, period of self-modulation may be reached due to varying of position of the reflector. The theory deductions are supported by the results of experimental investigation into 30 GHz region relativistic gyrotron with external reflections [ru

Identification of ALV-J associated acutely transforming virus Fu-J carrying complete v-fps oncogene.

Science.gov (United States)

Wang, Yixin; Li, Jianliang; Li, Yang; Fang, Lichun; Sun, Xiaolong; Chang, Shuang; Zhao, Peng; Cui, Zhizhong

2016-06-01

Transduction of oncogenes by ALVs and generation of acute transforming viruses is common in natural viral infections. In order to understand the molecular basis for the rapid oncogenicity of Fu-J, an acutely transforming avian leukosis virus isolated from fibrosarcomas in crossbreed broilers infected with subgroup J avian leukosis virus (ALV-J) in China, complete genomic structure of Fu-J virus was determined by PCR amplification and compared with those of Fu-J1, Fu-J2, Fu-J3, Fu-J4, and Fu-J5 reported previously. The results showed that the genome of Fu-J was defective, with parts of gag gene replaced by the complete v-fps oncogene and encoded a 137 kDa Gag-fps fusion protein. Sequence analysis revealed that Fu-J and Fu-J1 to Fu-J5 were related quasi-species variants carrying different lengths of v-fps oncogenes generated from recombination between helper virus and c-fps gene. Comparison of virus carrying v-fps oncogene also gave us a glimpse of the molecular characterization and evolution process of the acutely transforming ALV.

Design and operation of 140 GHz gyrotron oscillators for power levels up to 1 MW CW

Energy Technology Data Exchange (ETDEWEB)

Jory, H.; Bier, R.; Craig, L.J.; Felch, K.; Ives, L.; Lopez, N.; Spang, S.

1986-12-01

Varian has designed and tested 140 GHz gyrotron oscillators that have generated output powers of 100 kW CW and 200 kW for 1 ms pulses. Upcoming tubes will be designed to operate at power levels of 200 kW CW and ultimately up to 1 MW CW. The important design considerations which are addressed in the higher power tubes include the design of the electron gun, interaction circuit, and output window. These issues will be discussed and the results of the earlier 140 GHz gyrotron work at Varian will be summarized.

Design and operation of 140 GHz gyrotron oscillators for power levels up to 1 MW CW

International Nuclear Information System (INIS)

Jory, H.; Bier, R.; Craig, L.J.; Felch, K.; Ives, L.; Lopez, N.; Spang, S.

1986-12-01

Varian has designed and tested 140 GHz gyrotron oscillators that have generated output powers of 100 kW CW and 200 kW for 1 ms pulses. Upcoming tubes will be designed to operate at power levels of 200 kW CW and ultimately up to 1 MW CW. The important design considerations which are addressed in the higher power tubes include the design of the electron gun, interaction circuit, and output window. These issues will be discussed and the results of the earlier 140 GHz gyrotron work at Varian will be summarized

Fučík spectra for vector equations

Directory of Open Access Journals (Sweden)

Christian Fabry

2000-01-01

Full Text Available Let $L:\\hbox{dom} L\\subset L^2(\\Omega;R^N\\rightarrow L^2(\\Omega;R^N$ be a linear operator, $\\Omega$ being open and bounded in $R^M$. The aim of this paper is to study the Fu\\v c\\'\\i k spectrum for vector problems of the form $Lu=\\alpha Au^+ -\\beta Au^-$, where $A$ is an $N\\times N$ matrix, $\\alpha, \\beta$ are real numbers, $u^+$ a vector defined componentwise by $(u^+_i=\\max\\{u_i,0\\}$, $u^-$ being defined similarly. With $\\lambda^*$ an eigenvalue for the problem $Lu=\\lambda Au$, we describe (locally curves in the Fučík spectrum passing through the point $(\\lambda^*,\\lambda^*$, distinguishing different cases illustrated by examples, for which Fučík curves have been computed numerically.

Parasitic oscillation in and suppression of a gyro BW mode in a low-Q 8 GHz gyrotron

International Nuclear Information System (INIS)

Muggli, P.; Tran, M.Q.; Tran, T.M.

1991-12-01

The parasitic oscillation of the TE o 21 gyrotron Backward Wave (gyro BW) mode is observed in a low-Q, 8 GHz TE o 011 gyrotron. Although at low power (P BW o 011 mode efficiency of less than 0.25. The parasitic oscillation is suppressed by operating the gyrotron with a negative magnetic field gradient along the electron beam, which allows the maximum efficiency to reach 0.40 and the output power to be multiplied by a factor varying from 1.4 to 1.7. The optimum efficiency curve of the TE o 011 mode indicates that the low-Q cavity behaves as a much higher Q diff cavity. Too large magnetic field gradient and α values favour the TE o 012 longitudinal mode, which oscillates in place of the TE o 011 mode and limits its maximum output power. This competitive process is responsible for the high-Q like output power. (author) 14 figs., 14 refs

Microwave generation for magnetic fusion energy applications: Task A -- Experimental and numerical study of microwave sources for ECRH incorporating depressed collectors and with ITER-relevant parameters, and Task B -- Theory and modeling of high frequency, high power gyrotron operation. Final report, July 15, 1994--July 14, 1995

International Nuclear Information System (INIS)

1995-01-01

A proof-of-principle short pulse (∼ 100 ns) experiment has successfully demonstrated operation of a sheet-beam FEL amplifier with output power of 250 kW at 86 Ghz and with 24 dB saturated gain and ∼ 3% efficiency. Gain in the linear region was 30 dB. Measured performance parameters were in good agreement with predictions of a multi-mode, time dependence code. Also, a code has been developed to design depressed collectors which will enhance efficiency of ECRH sources (both FELs and gyrotrons). Extensive analytical and theoretical work in support of high power gyrotron development at Varian and MIT, and in support of ITER has been carried out. Specific studies are described. The effect of beam quality on the operation of the 145 GHz gyrotrons at MIT has been characterized using experimentally measured beam velocity distribution functions. The observed performance of these devices is consistent with a 10% RMS perpendicular velocity spread. An extensive study of mode competition in the 110 GHZ experiments at Varian and MIT has been carried out. Design criteria for the suppression of parasitic modes have been given for these experiments. The issues of mode competition and beam quality in the proposed 170 GHz megawatt gyrotrons for ITER have been investigated. Designs of cavities which eliminate unwanted modes have been made, and their sensitivity to beam quality studied. The constraints of lower power density and absence of mode competition coupled with the anticipated beam quality restrict efficiency. Efficiency can be improved by increasing the power density in the wall, improving beam quality, or perhaps by using a more advanced cavity. Studies of the causes of velocity spread in MIG guns have been initiated. Further, the effect of beam cavity misalignment on mode competition has been addressed

γ-Tocotrienol prevents 5-FU-induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5-FU-induced activation of Nrf2.

Science.gov (United States)

Takano, Hideyuki; Momota, Yukihiro; Kani, Kouichi; Aota, Keiko; Yamamura, Yoshiko; Yamanoi, Tomoko; Azuma, Masayuki

2015-04-01

Chemotherapy-induced oral mucositis is a common adverse event in patients with oral squamous cell carcinoma, and is initiated through a variety of mechanisms, including the generation of reactive oxygen species (ROS). In this study, we examined the preventive effect of γ-tocotrienol on the 5-FU-induced ROS production in human oral keratinocytes (RT7). We treated RT7 cells with 5-FU and γ-tocotrienol at concentrations of 10 µg/ml and 10 nM, respectively. When cells were treated with 5-FU alone, significant growth inhibition was observed as compared to untreated cells. This inhibition was, in part, due to the ROS gene-rated by 5-FU treatment, because N-acetyl cysteine (NAC), a ROS scavenger, significantly ameliorated the growth of RT7 cells. γ-tocotrienol showed no cytotoxic effect on the growth of RT7 cells. Simultaneous treatment of cells with these agents resulted in the significant recovery of cell growth, owing to the suppression of ROS generation by γ-tocotrienol. Whereas 5-FU stimulated the expression of NF-E2-related factor 2 (Nrf2) protein in the nucleus up to 12 h after treatment of RT7 cells, γ-tocotrienol had no obvious effect on the expression of nuclear Nrf2 protein. Of note, the combined treatment with both agents stabilized the 5-FU-induced nuclear Nrf2 protein expression until 24 h after treatment. In addition, expression of Nrf2-dependent antioxidant genes, such as heme oxygenase-1 (HO-1) and quinone oxidoreductase-1 (NQO-1), was significantly augmented by treatment of cells with both agents. These findings suggest that γ-tocotrienol could prevent 5-FU-induced ROS generation by stabilizing Nrf2 activation, thereby leading to ROS detoxification and cell survival in human oral keratinocytes.

Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression.

Science.gov (United States)

Wang, Weicheng; Guo, Wenjie; Li, Lele; Fu, Zan; Liu, Wen; Gao, Jian; Shu, Yongqian; Xu, Qiang; Sun, Yang; Gu, Yanhong

2016-12-01

5-FU is the first line therapy for colorectal cancer, however, treatment effect is often hampered by the development of drug resistance or toxicity at high doses. Andrographolide is a natural diterpenoid from Andrographis paniculata which has anti-bacterial, anti-antiviral and anti-inflammation activities. In the current study, we test the hypothesis that Andrographolide reverses 5-FU resistance in colorectal cancer and examine the underlying mechanism. In vitro and vivo studies indicated that Andrographolide treatment significantly re-sensitizes HCT116/5-FUR cells (HCT116 cells which are 5-FU resistant) to cytotoxicity of 5-FU. Mechanism analysis showed that Andrographolide/5-FU co-treatment elevated apoptosis level of HCT116/5-FUR cells with highly increased level of BAX. By using biotin-Andrographolide pull down and cellular thermal shift assay, we found out that Andrographolide can directly target to BAX. Andrographolide-BAX interaction prevented BAX degradation, enhancing mitochondria-mediated apoptosis thus reversed 5-FU resistance while BAX silence diminished this effect. Further, by analyzing patient samples who received 5-FU involved chemotherapy, we found that expression level of BAX is correlated with PFS. Our results here provide a novel combination treatment strategy, especially for patients with 5-FU-resistant tumors expressing low level of BAX. Meanwhile, we also proposed that BAX expression may be a predicted and prognosis marker of 5-FU involved chemotherapy. Copyright © 2016 Elsevier Inc. All rights reserved.

Synthesis of mig-type electron guns for gyrotrons

International Nuclear Information System (INIS)

Castro, J.J.B. de; Montes, A.; Silva, C.A.B.

1984-01-01

A synthesis method is used in the design of axially symmetrical guns in the moderate to high space charge regime. Self-consistent equations for the temperature limited emission case are used to represent the beam and solve the internal problem, under the requirement of laminar flow. The external problem is solved by integrating the equations with boundary conditions defined by the analytically extended solutions of the internal problem. This technique will be used in the development of INPE's gyrotron. (Author) [pt

5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice

International Nuclear Information System (INIS)

Wang, Yongsheng; Gong, Changyang; Yang, Li; Wu, Qinjie; Shi, Shuai; Shi, Huashan; Qian, Zhiyong; Wei, Yuquan

2010-01-01

Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy. A biodegradable PEG-PCL-PEG (PECE) triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model. The hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity. Our data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers

New window materials for high power gyrotron

International Nuclear Information System (INIS)

Afsar, M.N.; Hua Chi

1993-01-01

A single free standing synthetic diamond window seems to have higher absorption coefficient value at millimeter wavelength region at this time although it is claimed that it possesses good mechanical strength and higher thermal conductivity characteristics. It certainly does not rule out the use of diamond film on single crystal high resistivity silicon to improve its mechanical strength and thermal conductivity. One may have to use an appropriate film thickness for a particular wavelength in gyrotron window application. It is also necessary to use an appropriate thickness for the silicon perhaps equivalent to a quaterwavelength in order to avoid the reflection mismatch

Startup and mode competition in a 420 GHz gyrotron

Science.gov (United States)

Qixiang Zhao, A.; Sheng Yu, B.; Tianzhong Zhang, C.

2017-09-01

In the experiments of a 420 GHz second-harmonic gyrotron, it is found that the electron beam voltage and current ranges for single mode operation of TE17.4 are slightly narrower than those in the simulation. To explain this phenomenon, the startup scenario has been investigated with special emphasis on mode competition. The calculations indicate that the decreases of the operating ranges are caused by the voltage overshoot in the startup scenario.

The Use of a 28 GHz Gyrotron for EBW Startup Experiments on MAST

Science.gov (United States)

Caughman, J. B.; Bigelow, T. S.; Diem, S. J.; Peng, Y. K. M.; Rasmussen, D. A.; Shevchenko, V.; Hawes, J.; Lloyd, B.

2009-11-01

The use of electron Bernstein waves for non-inductive plasma current startup in MAST has recently been demonstrated [1]. The injection of 100 kW at 28 GHz generated plasma currents of up to 33 kA without the use of solenoid flux, and limited solenoid assist resulted in up to 55 kA of plasma current. A higher power 28 GHz gyrotron, with power levels of up to 300 kW for 0.5 seconds, is currently being commissioned. It is being used to investigate the scaling of startup current with microwave power and power profile as a function of time. Power modulation experiments are also being explored. Gyrotron performance and experimental results will be presented. [4pt] [1] V. Shevchenko, et al., Proceedings of the 15^th Joint Workshop on ECE and ECRH, Yosimite, USA, p. 68 (2009)

Experimental considerations concerning the velocity measurement of the relativistic electron beam in a gyrotron by means of Thomson scattering

International Nuclear Information System (INIS)

Siegrist, M.R.; Soumagne, G.; Tran, M.Q.

1992-11-01

The feasibility of Thomson scattering to determine the beam velocity in a gyrotron has been analyzed and preliminary experiments to implement such a system on our 100 GHz quasi-optical gyrotron are reported. Although the project had to be abandoned due to technical problems, the conclusions are that for the 90 o scattering arrangement discussed it should be possible to determine at least one velocity component with an acceptable signal-to-noise ratio. (author) 11 figs., 10 refs

Upgrade Of The TH1506B 118 GHz Gyrotron Using Modeing Tools

International Nuclear Information System (INIS)

Darbos, C.; Bouquey, F.; Lambert, R.; Magne, R.; Traisnel, E.; Arnold, A.; Prinz, H. O.; Thumm, M.; Hogge, J. P.; Lievin, C.

2007-01-01

The first TH1506B prototype showing problems of overheating and spurious oscillations, a new modified gyrotron was built. During the tests, the extwo peaks, which was never predicted by simulations. Various low evel tests were performed on the mode converter with different shapes for the launcher but without real improvement. Besides measurements, the use of a new software Surf3D[l] showed that the problem mainly comes from the 3rd mirror whose curvature is too high and not well taken nto account by the calculation. This analysis software is based on ntegral equations and the complete 3D modelling alowed to determine a new profile for the 3rd mirror. An aluminium model of a new mirror was manufactured and thorough low level tests made at FZK showed that there was no double peak.The next step would consist in building a gyrotron based on this new design, to confirm the simulation and to valdate it for long pulses

Transmission Line for 258 GHz Gyrotron DNP Spectrometry

Science.gov (United States)

Bogdashov, Alexandr A.; Belousov, Vladimir I.; Chirkov, Alexey V.; Denisov, Gregory G.; Korchagin, Vyacheslav V.; Kornishin, Sergey Yu.; Tai, Evgeny M.

2011-06-01

We describe the design and test results of the transmission line for liquid-state (LS) and solid-state (SS) DNP spectrometers with the second-harmonic 258.6 GHz gyrotron at the Institute of the Biophysical Chemistry Center of Goethe University (Frankfurt). The 13-meter line includes a mode converter, HE11 waveguides, 4 mitre bends, a variable polarizer-attenuator, directional couplers, a water-flow calorimeter and a mechanical switch. A microwave power of about 15 W was obtained in the pure HE11 mode at the spectrometer inputs.

Development of Gyrotron and JT-60U EC heating system for fusion reactor

International Nuclear Information System (INIS)

Sakamoto, K.; Kasugai, A.; Ikeda, Yo.

2003-01-01

The progress of ECH technology, for ITER and JT-60U tokamak, are presented. In the development of gyrotron, 0.9MW/9.2sec, 0.5MW/30sec, 0.3MW/60sec, etc. have been demonstrated at 170GHz. At 110GHz, 1.3MW/1.2sec, 1.2MW/4.1sec, 1MW/5sec were obtained. It is found that the reduction of the stray radiation and the enhancement of cooling capability are keys for CW operation. Four 110GHz gyrotrons are under operation in the ECH system of JT-60U. The power up to approximately 3MW/2.7sec was injected into the plasma through the poloidally movable mirrors, and contributed to the electron heating up to 26keV(n e ∼0.5x10 13 cm -3 ), and the suppression of the neo-classical tearing mode. (author)

Development of gyrotron and JT-60U EC heating system for fusion reactor

International Nuclear Information System (INIS)

Sakamoto, K.; Kasugai, A.; Ikeda, Yo.

2003-01-01

The progress of ECH technology, for ITER and JT-60U tokamak, are presented. In the development of gyrotron, 0.9MW/9.2sec, 0.5MW/30sec, 0.3MW/60sec, etc. have been demonstrated at 170GHz. At 110GHz, 1.3MW/1.2sec, 1.2MW/4. 1sec. 1MW/5sec were obtained. It is found that the reduction of the stray radiation and the enhancement of cooling capability are keys for CW operation. Four 110GHz gyrotrons are under operation in the ECH system of JT-60U. The power up to approximately 3MW/2.7sec was injected into the plasma through the poloidally movable mirrors, and contributed to the electron heating up to 26keV(n e ∼0.5x10 13 cm -3 ), and the suppression of the neo-classical tearing mode. (author)

Particle-in-cell analysis of beam-wave interaction in gyrotron cavity with tapered magnetic field

Energy Technology Data Exchange (ETDEWEB)

Kumar, A., E-mail: anil.gyrotron@gmail.com [Gyrotron Lab., Microwave Tube Area, Central Electronics Engineering Research Inst. (CEERI, CSIR), Pilani, Rajasthan (India); Banasthali Univ., Dept. of Physics, Banasthali, Rajasthan (India); Khatun, H.; Kumar, N.; Singh, U.; Sinha, A.K. [Gyrotron Lab., Microwave Tube Area, Central Electronics Engineering Research Inst. (CEERI, CSIR), Pilani, Rajasthan (India); Vyas, V. [Banasthali Univ., Dept. of Physics, Banasthali, Rajasthan (India)

2010-11-15

A commercially available electromagnetic simulator -- MAGIC, a particle-in-cell (PIC) code -- has been used to carry out a comparative study of the beam-wave interaction under uniform and tapered magnetic field profiles of a 42 GHz, 200kW gyrotron. The magnetic field profile across the resonant cavity varies by ±6.5% with a peak value of 1.615 T. The MAGIC simulation shows the desire performance of the gyrotron under both magnetic field conditions with an operating mode TE{sub 03} and a pitch factor of 1.26. The analysis of the simulated results show that stability in the power growth was reached more quickly and achieved higher output power in the case of a tapered magnetic field. (author)

A high-voltage equipment (high voltage supply, high voltage pulse generators, resonant charging inductance, synchro-instruments for gyrotron frequency measurements) for plasma applications

International Nuclear Information System (INIS)

Spassov, Velin

1996-01-01

This document reports my activities as visitor-professor at the Gyrotron Project - INPE Plasma Laboratory. The main objective of my activities was designing, construction and testing a suitable high-voltage pulse generator for plasma applications, and efforts were concentrated on the following points: Design of high-voltage resonant power supply with tunable output (0 - 50 kV) for line-type high voltage pulse generator; design of line-type pulse generator (4 microseconds pulse duration, 0 - 25 kV tunable voltage) for non linear loads such as a gyrotron and P III reactor; design of resonant charging inductance for resonant line-type pulse generator, and design of high resolution synchro instrument for gyrotron frequency measurement. (author)

Quasi-optical mode converter for a coaxial cavity gyrotron

International Nuclear Information System (INIS)

Jin, J.

2007-03-01

This work concentrates on the synthesis of the quasioptical mode converter for the 170 GHz, TE 34,19 -mode, 2MW, CW coaxial-cavity gyrotron at Forschungszentrum Karlsruhe (FZK). The improvement of the general method for the design of so-call dimpled-wall launcher to provide a good Gaussian mode content is described. This method is verified through the design of a launcher operating in the TE 22,6 mode at 118 GHz. A phase rule is proposed as a quality criterion for monitoring the optimization and the choices of parameters of the quasi-optical mode converter. High-order harmonics introduced to the launcher wall deformations are proposed for this gyrotron. The launcher is numerically optimized, the fields on the cut edges are suppressed. The fields in the launcher are well approximated by the waveguide modes, the radiated fields are calculated using the scalar diffraction integral. The procedure for the numerical optimization of the mirror system is improved, the tolerance conditions of the phase correcting mirrors are investigated. A conversion efficiency of 95.8% to the circular fundamental Gaussian distribution with 20mm beam waist and power transmission of 90% are achieved in the window plane using the optimized quasi-optical mode converter. The methods to ameliorate the initial conditions of the phase correcting mirrors are explored. (orig.)

Zuordnungsprozesse bei Fußballzuschauern - Zur Salienz teambezogener Kategorien

OpenAIRE

Roschmann, Regina

2013-01-01

Sport im Allgemeinen und Fußball im Besonderen erfreuen sich nicht nur unter aktiven Sportlern, sondern auch unter Zuschauern aktuell hoher Beliebtheit. Angesichts teils enormer Einschaltquoten scheint es wahrscheinlich, dass Fußballspiele nicht nur von Fans der beteiligten Mannschaften verfolgt werden. Dies kann sowohl gänzlich neutrale Zuschauer als auch Anhänger anderer Teams betreffen. Während Fans allerdings durch die Literatur bereits ausführliche Aufmerksamkeit erfahren haben und durch...

Design and simulation of a ~390 GHz seventh harmonic gyrotron using a large orbit electron beam

Science.gov (United States)

Li, Fengping; He, Wenlong; Cross, Adrian W.; Donaldson, Craig R.; Zhang, Liang; Phelps, Alan D. R.; Ronald, Kevin

2010-04-01

A ~390 GHz harmonic gyrotron based on a cusp electron gun has been designed and numerically modelled. The gyrotron operates at the seventh harmonic of the electron cyclotron frequency with the beam interacting with a TE71 waveguide mode. Theoretical as well as numerical simulation results using the 3D particle-in-cell code MAGIC are presented. The cusp gun generated an axis-encircling, annular shaped electron beam of energy 40 keV, current 1.5 A with a velocity ratio α of 3. Smooth cylindrical waveguides have been studied as the interaction cavities and their cavity Q optimized for 390 GHz operation. In the simulations ~600 W of output power at the design frequency has been demonstrated.

Inhibition effects of a negative electret 5-FU patch on the growth of a hypertrophic scar

Science.gov (United States)

Wang, YUAN; Lili, XU; Ping, HUANG; Xiaoqiang, AN; Lili, CUI; Jian, JIANG

2018-05-01

In this study, the hypertrophic scar (HS) model in rats was established. 5-fluorouracil (5-FU) patch, ‑1000 V and ‑2000 V polypropylene (PP) electret 5-FU patches were prepared and applied onto the wound. The in vitro permeation experiment was performed using the Franz diffusion cell system to determine the permeation cumulative amount and retention amount of 5-FU through/in scar skin. The inhibition effect of negative electret on growth of HS was studied by hematoxylin-eosin (HE) staining, Masson staining and the immunohistologicall methods. The permeation study indicated that a negative electret could enhance the permeation and retention of 5-FU through and in scar skin respectively. HE staining and Masson staining indicated a better effect for ‑1000 V and ‑2000 V electret 5-FU patches on HS inhibition after 28 d post-wounding compared with 5-FU patch. The immunohistological study showed much more reduced expressions of collegan type I, collegan type III, TGF-β1 and HSP47 in scar tissue after application of negative electret 5-FU patches than those of 5-FU patch. A negative electret 5-FU patch may be advantageous for HS treatment.

Overview of the Fusion Z-Pinch Experiment FuZE

Science.gov (United States)

Weber, T. R.; Shumlak, U.; Nelson, B. A.; Golingo, R. P.; Claveau, E. L.; McLean, H. S.; Tummel, K. K.; Higginson, D. P.; Schmidt, A. E.; UW/LLNL Team

2016-10-01

Previously, the ZaP device, at the University of Washington, demonstrated sheared flow stabilized (SFS) Z-pinch plasmas. Instabilities that have historically plagued Z-pinch plasma confinement were mitigated using sheared flows generated from a coaxial plasma gun of the Marshall type. Based on these results, a new SFS Z-pinch experiment, the Fusion Z-pinch Experiment (FuZE), has been constructed. FuZE is designed to investigate the scaling of SFS Z-pinch plasmas towards fusion conditions. The experiment will be supported by high fidelity physics modeling using kinetic and fluid simulations. Initial plans are in place for a pulsed fusion reactor following the results of FuZE. Notably, the design relies on proven commercial technologies, including a modest discharge current (1.5 MA) and voltage (40 kV), and liquid metal electrodes. Supported by DoE FES, NNSA, and ARPA-E ALPHA.

The Effect of 5-FU and Radiation on A549 Cells In Vitro

Energy Technology Data Exchange (ETDEWEB)

Lee, Myung Za [Hanyang University College of Medicine, Seoul (Korea, Republic of); Chun, Ha Chong [Medical College of Virgina, Richmond (United States); Lee, Won Young [Yonsei University College of Medicine, Seoul (Korea, Republic of)

1989-06-15

Effects of ionizing radiation alone and combined with chemotherapy on tumor growth and it clonal specificity Monitored by changes in distribution of chromosome number were studies in A549 cell line originated from human adenocarcinoma of the lung. Radiation (300 rad, 600 rad and 900 rad) were delivered with or without 5-FU. Forty eight hours later, 57.5% of growth inhibition of cell was Seen in cells treated with 5-FU concentration of 0.47g/ml for 24 hr exposure. Cell survival carves after radiation with and without 5-FU were made. Chromosomal analysis of cells in metaphase in control, and in cells treated with 300 rad of radiation, or 0.47g/ml of 5-FU treatment, and combined treatment of cloth were 77ne to examine the changes in ploidy and number of chromosome. Radiation combined with 5-FU enhanced growth inhibition of A549 cells. However, no evidence of synergetic effects in growth inhibition was observed in the cells treated with the combination therapy. Pattern of chromosomal distribution of survived cells were shifted from hyperploidy to hypoploidy by single dose of radiation(300 rad). As radiation dose increased a large number of hypoploidy cells were observed. Following treatment of cells with 5-FU, chomosomal distribution of survived cells were also shifted to hypodiploidy, which were seen in cells treated with radiation. The cell treated with 5-FU and followed by radiation within 24 hrs had cell with increased number of hypodiploidy cells. Almost same type of chromosomal changes were reproduced in cells treated with combined treatment with radiation and 5-FU. Minor differences were that cells with fewer number of chromosome were more frequent in cells treated with combined therapy. Further increase in cells of hypoploidy(93%) having 1-10 chromosome were induced by additional radiation. Therefore, the enhanced therapeutic effect of 5-FU combined with radiation of A549 cells appeared to be additive rather than synergistic.

Status of the development of the EU 170 GHz/1 MW/CW gyrotron

Energy Technology Data Exchange (ETDEWEB)

Pagonakis, Ioannis Gr., E-mail: ioannis.pagonakis@kit.edu [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Albajar, Ferran [The European Joint Undertaking for ITER and The Development of Fusion Energy, Barcelona (Spain); Alberti, Stefano [École Polytechnique Fédérale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), Lausanne (Switzerland); Avramidis, Konstantinos [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Bonicelli, Tullio [The European Joint Undertaking for ITER and The Development of Fusion Energy, Barcelona (Spain); Braunmueller, Falk [École Polytechnique Fédérale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), Lausanne (Switzerland); Bruschi, Alex [Plasma Physics Institute, National Research Council of Italy, Milano (Italy); Chelis, Ioannis [School of Electrical and Computer Engineering, National Technical University of Athens (Greece); Cismondi, Fabio [The European Joint Undertaking for ITER and The Development of Fusion Energy, Barcelona (Spain); Gantenbein, Gerd [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Hermann, Virgile [Thales Electron Devices (TED), Vélizy-Villacoublay (France); Hesch, Klaus [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Hogge, Jean-Philippe [École Polytechnique Fédérale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), Lausanne (Switzerland); Jelonnek, John; Jin, Jianbo; Illy, Stefan [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Ioannidis, Zisis C. [Faculty of Physics, National and Kapodistrian University of Athens (Greece); Kobarg, Thorsten [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); and others

2015-10-15

The progress in the development of the European 170 GHz, 1 MW/CW gyrotron for electron cyclotron heating & current drive (ECH&CD) on ITER is reported. A continuous wave (CW) prototype is being manufactured by Thales Electron Devices (TED), France, while a short-pulse (SP) prototype gyrotron is in parallel under manufacture at Karlsruhe Institute of Technology (KIT), with the purpose of validating the design of the CW industrial prototype components. The fabrication of most of the sub-assemblies of the SP prototype has been completed. In a first step, an existing magnetron injection gun (MIG) available at KIT was used. Despite this non-ideal configuration, the experiments provided a validation of the design, substantiated by an excellent agreement with numerical simulations. The tube, operated without a depressed collector, is able to produce more than 1 MW of output power with efficiency in excess of 30%, as expected, and compatible with the ITER requirements.

Novel dielectric photonic-band-gap resonant cavity loaded in a gyrotron

International Nuclear Information System (INIS)

Chen Xiaoan; Liu Gaofeng; Tang Changjian

2010-01-01

A novel resonant cavity composed of a periodic, multilayer, dielectric photonic crystal is proposed. Using the transfer matrix method and the Bloch theorem for periodic systems, an analysis on the band-gap property of such a structure is made, and the basic electromagnetic property of the photonic-band-gap resonant cavity (PBGC) is preliminarily exhibited. The theoretical studies and the cold cavity simulation results obtained from a high-frequency structure simulator are presented. On the basis of the present research, such a PBGC is quite similar to the two-dimensional PBGC made of triangular lattices of metal rods with a defect at its centre, in which a frequency selectivity is similarly demonstrated. Because of its unique electromagnetic property, the cavity has many promising applications in active and passive devices operating in the millimetre, sub-millimetre, and even THz wave range. As a specific application, the feasibility of substituting the traditional cylindrical resonant cavity loaded in a gyrotron for a dielectric PBGC to achieve a transverse high-order operation is discussed under the consideration of the electromagnetic features of the cavity. The study shows the great potential value of such a cavity for gyrotron devices.

Kritik Atas Modernitas Dalam Novel Bilangan Fu Karya Ayu Utami

Directory of Open Access Journals (Sweden)

Bramantio Bramantio

2015-06-01

Full Text Available Artikel ini bertujuan untuk mengungkap kritik atas modernitas dalam novel Bilangan Fu karya Ayu Utami. Dengan memanfaatkan naratologi Tzvetan Todorov, dapat dipahami aspek verbal Bilangan Fu, yaitu sudut pandang, pencerita, dan tuturannya. Berdasarkan penceritaannya, novel ini merupakan novel polifonik, karnivalistik, sekaligus metafiksi. Berdasarkan kontennya, novel ini menghadirkan sejumlah kritik atas modernitas, khususnya berkaitan dengan semangat modernitas yang cenderung melihat segala sesuatu secara monodimensional, hanya ada satu kebenaran, dan liyan diabaikan. Bilangan Fu merupakan novel yang merefleksikan zamannya. Novel ini berhasil menyegarkan cara pandang masyarakat Indonesia, atau setidaknya menghadirkan sesuatu untuk dipikirkan dan dipertimbangkan kembali, berkaitan dengan diri, lingkungan, dan semesta raya. Novel ini mengembalikan manusia ke hakikatnya, yaitu kemanusiaan. Abstract: This article aims to reveal criticism on modernity in Ayu Utami’s novel Bilangan Fu. Tzvetan Todorov’s theory of narrative provided a framework to understand the novel’s verbal aspects, which are point of view, narrator, dan its voice. Based on its narrative, this novel is polyphonic, carnivalistic, and metafictional. Based on its content, it presents criticism on modernity, particularly on spirit of modernity that tends to see everything in monodimensional; there is only one truth, and the other is ignored. Bilangan Fu is a novel that reflects its time. It successfully refreshes the perspective of Indonesian society, or at least brings something to think about, related to the self, environment, and the universe. In the end, it brings back human being to their core, their humanity. Key Words: novel; point of view; narrator; criticism; modernity

Ring-shaped nebulae around FU Orionis stars

International Nuclear Information System (INIS)

Goodrich, R.W.

1987-01-01

Observational data on the morphology and spectra of the nebulae surrounding V1057 Cyg, V1515 Cyg, and V1735 Cyg stars are presented and studied. The data reveal that V1735 Cyg is more highly reddened than the nebula and the spectra of all three nebulae are from reflection. A simple model for the dust shell is proposed and it is argued that the shells may indicate a relatively advanced evolutionary state for the FU Orionis star. The relation between the shells and the evolution of the stars is examined. The models of Herbig (1977), Mould et al. (1978), Larson (1980), and Hartmann and Kenyon (1985), which are utilized to analyze the FU Orionis outburst phenomenon, are tested. 23 references

Near fatal 5-FU gut toxicity post surgery--remarkable effect of high-dose sucralfate.

Science.gov (United States)

Toh, James Wei Tatt; Morris, David; Chen, Zhuoran; Chen, Cindy

2015-06-01

The objective of this review article and case report was to investigate the effectiveness of high-dose sucralfate on severe life-threatening 5-fluorouracil (5-FU) gut toxicity, with reference to, but not limited to dihydropyrimidine dehydrogenase (DPD) deficiency. A search was conducted on PubMed from 1950 to July 2013 for original studies on 5-FU gut toxicity and sucralfate. Studies were limited to human trials and English language and all articles included in this study were assessed with the application of predetermined selection criteria. Each article was then reviewed independently by two reviewers. A case report from our own centre was included in this review. From 33 results, 6 manuscripts were identified including 4 randomized controlled trial. One trial evaluated the use of sucralfate to alleviate stomatitis in patients with 5-FU-based chemotherapy. The other three trials evaluated the role of sucralfate in radiation toxicity. There was one case report which showed gastroscopy confirmed normalization of severe dysplastic erosive gastroduodenitis attributed to hepatic arterial infusion of 5-FU following a 2-month course of sucralfate and cimetidine and one case series showing clinical and sigmoidoscopically demonstrated improvement in ulcerative colitis in majority of patients receiving sucralfate enemas. There was no current literature specifically focussed on the role of sucralfate in 5-FU gut toxicity. Our case report describes the clinical course and successful treatment with sucralfate of a patient with Pseudomyxoma peritonei (PMP) who experienced 5-FU gut toxicity resulting in life-threatening bleeding due to presumed DPD deficiency post intraperitoneal 5-FU administration. This review article showed a lack of literature concerning the use of sucralfate in 5-FU gut toxicity. In our patient's case, sucralfate had a crucial role in the management of near fatal 5-FU gut toxicity, and further evaluation is required.

Improved Design of Beam Tunnel for 42 GHz Gyrotron

Science.gov (United States)

Singh, Udaybir; Kumar, Nitin; Purohit, L. P.; Sinha, A. K.

2011-04-01

In gyrotron, there is the chance of generation and excitation of unwanted RF modes (parasite oscillations). These modes may interact with electron beam and consequently degrade the beam quality. This paper presents the improved design of the beam tunnel to reduce the parasite oscillations and the effect of beam tunnel geometry on the electron beam parameters. The design optimization of the beam tunnel has been done with the help of 3-D simulation software CST-Microwave Studio and the effect of beam tunnel geometry on the electron beam parameters has been analyzed by EGUN code.

Nonlinearly driven oscillations in the gyrotron traveling-wave amplifier

International Nuclear Information System (INIS)

Chiu, C. C.; Pao, K. F.; Yan, Y. C.; Chu, K. R.; Barnett, L. R.; Luhmann, N. C. Jr.

2008-01-01

By delivering unprecedented power and gain, the gyrotron traveling-wave amplifier (gyro-TWT) offers great promise for advanced millimeter wave radars. However, the underlying physics of this complex nonlinear system is yet to be fully elucidated. Here, we report a new phenomenon in the form of nonlinearly driven oscillations. A zero-drive stable gyro-TWT is shown to be susceptible to a considerably reduced dynamic range at the band edge, followed by a sudden transition into driven oscillations and then a hysteresis effect. An analysis of this unexpected behavior and its physical interpretation are presented.

Adoption, Cynical Detachment, and New Age Beliefs in Juno and Kung Fu Panda

OpenAIRE

Chen, Fu-jen

2017-01-01

In his article "Adoption, Cynical Detachment, and New Age Beliefs in Juno and Kung Fu Panda" Fu-Jen Chen situates his study within today's prevailing climate of global consumption to argue that the 2007 film Juno—featuring an unconventional portrayal of the adoption triad and a cynical detachment from public values—not only trivializes and depoliticizes the practice of adoption but also serves as an ideological supplement to today's global capitalism. Furthermore, Kung Fu Panda 1 & 2 (2008; 2...

[Anti-tumor effect of 5-FU-PLLA-CNTs on human gastric carcinoma cell lines in vitro].

Science.gov (United States)

Gu, Jun; Li, Maolan; Wu, Xiangsong; Wu, Wenguang; Zhang, Lin; Ding, Qichen; Yang, Jiahua; Weng, Hao; Ding, Qian; Bao, Runfa; Shu, Yijun; Liu, Yingbin

2014-04-01

To prepare cisPLLAtin-loaded polylactic acid/cnts, and to study the anti-tumor effect of 5-FU-PLLA-CNTs on human gastric carcinoma cell lines(MGC803 and MNK45). 5-FU-PLLA-CNTs were prepared with ultrasound emulsification. The morphology of 5-FU-PLLA-CNTs was determined by scanning electron microscope(SEM), and its drug loading and drug release curve in vitro were detected by UV-Vis-NIR spectrophotometer. Cells were divided into experiment, positive control and negative control groups. CCK8 method was used to test the cytotoxic effect of 5-FU-PLLA-CNTs in different concentrations on MGC803 and MNK45 cell proliferation. Flow cytometry was employed to measure the apoptotic rate of MGC803 and MNK45 cells before and after the intervention of 5-FU-PLLA-CNTs. Deep layer film of 5-FU-PLLA-CNTs was successfully established, whose drug-load rate was(4.54±0.43)%, entrapment rate was(21.56±2.36)%. In vitro release test showed release rate within 24 h of 5-FU-PLLA-CNTs was 23.9% in a as lowly increasing manner, and accumulating release rate was 85.3% at day 31. CCk8 experiment revealed, as compared to control group, 5-FU-PLLA-CNTs significantly inhibited the proliferation of two cell lines in dose-dependent and time-dependent manner. The best 5-FU-PLLA-CNTs concentration of inhibition for human gastric cancer cell lines was 1 mg/well. Flow cytometry indicated the apoptotic rate of MGC803 and MNK45 cells in experiment group treated by 1 mg/well 5-FU-PLLA-CNTs significantly increased as compared to negative control group (P0.05). The 5-FU-PLLA-CNTs has good drug sustained-release capacity, and can significantly kill and inhibit the proliferation of MGC803 and MNK45 cell lines.

Kung-fu versus swimming training and the effects on balance abilities in young adolescents.

Science.gov (United States)

Baccouch, Rym; Rebai, Haithem; Sahli, Sonia

2015-11-01

Our purpose is to investigate the static balance control of young adolescents practicing kung-fu and swimming in order to find out which of these physical activities is the most effective in developing specific balance abilities in young adolescents. Comparative experimental study. University laboratory research. Three groups of 11-13-year-old boys (12 practicing Kung-Fu, 12 practicing swimming and 12 controls). Center of pressure (CoP) excursions were registered in upright bipedal and unipedal stances on a stabilometric force platform in eyes open (EO) and eyes closed (EC) conditions. Kung-fu practitioners control their balance (P Kung-fu training improved (P kung-fu practitioners. Both of these physical activities could be recommended for young adolescents as recreational or rehabilitation programs as they develop specific balance abilities that could be important for improving and maintaining optimal health. Copyright © 2015 Elsevier Ltd. All rights reserved.

5FU and oxaliplatin-containing chemotherapy in two dihydropyrimidine dehydrogenase-deficient patients

NARCIS (Netherlands)

Reerink, O; Mulder, NH; Szabo, BG; Hospers, GAP

2004-01-01

Patients with a germline mutation leading to a deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme are at risk from developing severe toxicity on the administration of 5FU-containing chemotherapy. We report on the implications of this inborn genetic error in two patients who received 5FU

Anti-virus effect of traditional Chinese medicine Yi-Fu-Qing granule on acute respiratory tract infections.

Science.gov (United States)

Li, Anyuan; Xie, Yanying; Qi, Fanghua; Li, Jie; Wang, Peng; Xu, Shulan; Zhao, Lin

2009-08-01

Yi-Fu-Qing granule is a traditional Chinese medicine for the treatment of acute respiratory tract infections. The present study sought to investigate the anti-virus effects of Yi-Fu-Qing granule on acute respiratory infections with respiratory syncytial virus (RSV) and human adenoviruses type 3 (Ad3). The cytotoxicity of Yi-Fu-Qing granule was evaluated by the neutral red assay on HeLa cells. The antiviral effect of Yi-Fu-Qing granule was tested by observing the cytopathogenic effect (CPE) with a compound mixture of Isatis leaf as the positive control drug. The results indicated that the highest non-toxicity concentration of Yi-Fu-Qing granule on Hela cells was 1:100. The CPE reduction assay showed that Yi-Fu-Qing granule inhibited RSV and Ad3 replication at a concentration of 1:100. Thus, Yi-Fu-Qing granule may have a significant antivirus effect on acute respiratory tract infections with RSV and Ad3 infections and this could prove useful for further antivirus research on acute respiratory tract infections.

Velocity-space tomography of fusion plasmas by collective Thomson scattering of gyrotron radiation

DEFF Research Database (Denmark)

Salewski, Mirko; Jacobsen, A.S.; Jensen, Thomas

2016-01-01

-tonoise ratio becomes fairly low for MeV-range ions. Ions at any energy can be detected well by collective Thomson scattering of mm-wave radiation from a high-power gyrotron. We demonstrate how collective Thomson scattering can be used to measure 푓2퐷푣 in the MeV-range in reactor relevant plasmas...

Effect of ion compensation of the beam space charge on gyrotron operation

Energy Technology Data Exchange (ETDEWEB)

Fokin, A. P.; Glyavin, M. Yu. [Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod 603950 (Russian Federation); Nusinovich, G. S. [Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20742-3511 (United States)

2015-04-15

In gyrotrons, the coherent radiation of electromagnetic waves takes place when the cyclotron resonance condition between the wave frequency and the electron cyclotron frequency or its harmonic holds. The voltage depression caused by the beam space charge field changes the relativistic cyclotron frequency and, hence, can play an important role in the beam-wave interaction process. In long pulse and continuous-wave regimes, the beam space charge field can be partially compensated by the ions, which appear due to the beam impact ionization of neutral molecules of residual gases in the interaction space. In the present paper, the role of this ion compensation of the beam space charge on the interaction efficiency is analyzed. We also analyze the effect of the electron velocity spread on the limiting currents and discuss some effects restricting the ion-to-beam electron density ratio in the saturation stage. It is shown that the effect of the ion compensation on the voltage depression caused by the beam space charge field can cause significant changes in the efficiency of gyrotron operation and, in some cases, even result in the break of oscillations.

Design and simulation of a {approx}390 GHz seventh harmonic gyrotron using a large orbit electron beam

Energy Technology Data Exchange (ETDEWEB)

Li Fengping; He Wenlong; Cross, Adrian W; Donaldson, Craig R; Zhang Liang; Phelps, Alan D R; Ronald, Kevin, E-mail: Fengping.li@strath.ac.u [SUPA, Department of Physics, University of Strathclyde, Glasgow, G4 0NG (United Kingdom)

2010-04-21

A {approx}390 GHz harmonic gyrotron based on a cusp electron gun has been designed and numerically modelled. The gyrotron operates at the seventh harmonic of the electron cyclotron frequency with the beam interacting with a TE{sub 71} waveguide mode. Theoretical as well as numerical simulation results using the 3D particle-in-cell code MAGIC are presented. The cusp gun generated an axis-encircling, annular shaped electron beam of energy 40 keV, current 1.5 A with a velocity ratio {alpha} of 3. Smooth cylindrical waveguides have been studied as the interaction cavities and their cavity Q optimized for 390 GHz operation. In the simulations {approx}600 W of output power at the design frequency has been demonstrated.

RF Behavior of Cylindrical Cavity Based 240 GHz, 1 MW Gyrotron for Future Tokamak System

Science.gov (United States)

Kumar, Nitin; Singh, Udaybir; Bera, Anirban; Sinha, A. K.

2017-11-01

In this paper, we present the RF behavior of conventional cylindrical interaction cavity for 240 GHz, 1 MW gyrotron for futuristic plasma fusion reactors. Very high-order TE mode is searched for this gyrotron to minimize the Ohmic wall loading at the interaction cavity. The mode selection process is carried out rigorously to analyze the mode competition and design feasibility. The cold cavity analysis and beam-wave interaction computation are carried out to finalize the cavity design. The detail parametric analyses for interaction cavity are performed in terms of mode stability, interaction efficiency and frequency. In addition, the design of triode type magnetron injection gun is also discussed. The electron beam parameters such as velocity ratio and velocity spread are optimized as per the requirement at interaction cavity. The design studies presented here confirm the realization of CW, 1 MW power at 240 GHz frequency at TE46,17 mode.

Experimental results for a 1.5 MW, 110 GHz gyrotron oscillator with reduced mode competition

Science.gov (United States)

Choi, E. M.; Marchewka, C. D.; Mastovsky, I.; Sirigiri, J. R.; Shapiro, M. A.; Temkin, R. J.

2006-02-01

A new result from a 110GHz gyrotron at MIT is reported with an output power of 1.67MW and an efficiency of 42% when operated at 97kV and 41A for 3μs pulses in the TE22,6 mode. These results are a major improvement over results obtained with an earlier cavity design, which produced 1.43MW of power at 37% efficiency. These new results were obtained using a cavity with a reduced output taper angle and a lower ohmic loss when compared with the earlier cavity. The improved operation is shown experimentally to be the result of reduced mode competition from the nearby TE19,7 mode. The reduced mode competition agrees well with an analysis of the startup scenario based on starting current simulations. The present results should prove useful in planning long pulse and CW versions of the 110GHz gyrotron.

Experimental results for a 1.5 MW, 110 GHz gyrotron oscillator with reduced mode competition

International Nuclear Information System (INIS)

Choi, E.M.; Marchewka, C.D.; Mastovsky, I.; Sirigiri, J.R.; Shapiro, M.A.; Temkin, R.J.

2006-01-01

A new result from a 110 GHz gyrotron at MIT is reported with an output power of 1.67 MW and an efficiency of 42% when operated at 97 kV and 41 A for 3 μs pulses in the TE 22,6 mode. These results are a major improvement over results obtained with an earlier cavity design, which produced 1.43 MW of power at 37% efficiency. These new results were obtained using a cavity with a reduced output taper angle and a lower ohmic loss when compared with the earlier cavity. The improved operation is shown experimentally to be the result of reduced mode competition from the nearby TE 19,7 mode. The reduced mode competition agrees well with an analysis of the startup scenario based on starting current simulations. The present results should prove useful in planning long pulse and CW versions of the 110 GHz gyrotron

30 kV/10 mA solid state anode modulator for gyrotron plasma heating: design issues and results

International Nuclear Information System (INIS)

Fasel, D.; Lucia, C.; Ganuza, D.; Doyharzabal, I.

2001-01-01

Three 30 kV/10 mA solid state pulsed modulators have been delivered to the CRPP in Lausanne, by the company JEMA. Each modulator supplies the anode grid of a triode type gyrotron, used for heating purpose at the third harmonic in the TCV Tokamak. The main parameters of the final design are: the use of solid state technology, a floating output referred to the -80 kV of the gyrotron cathode potential, an output voltage range of -5 to 30 kV, 1 kHz square and sinusoidal modulation, fast switching off to -5 kV (10 μs) and pulsed operation (duty cycle of 1%). After studying and testing a solution based on regulated Mosfet transistors in series, a more stable alternative has been adopted. The final topology consists of a rectifier fed from an insulated 230 V input, a chopper, two inverter steps (for +30 and -5 kV) supplying two diode rectifiers bridges through HV transformers with two switches which commute the load to the positive or negative voltage, connected in series. This article presents the most significant aspects of the design, with special emphasis on the control principle. The final results will be presented in the context of normal operation, supplying a triode gyrotron

Development of 1 MW gyrotron and progress of ECH system for the GAMMA 10 tandem mirror in Tsukuba

International Nuclear Information System (INIS)

Imai, T.; Kariya, T.; Minami, R.; Shidara, H.; Endo, Y.; Harigae, M.; Nakamura, M.; Sakagoshi, Y.; Murofushi, N.; Ichimura, M.; Nakashima, Y.; Yoshikawa, M.; Yamaguchi, Y.; Sakamoto, Keishi; Kubo, S.; Shimozuma, T.; Mutoh, T.; Takahashi, H.; Mitsunaka, Y.

2008-10-01

High power gyrotrons with TE 4,2 cavity at 28 GHz and with TE 18,6 cavity and a diamond window at 77 GHz have been developed for GAMMA 10 and LHD in the joint program of NIFS and University of Tsukuba. The maximum outputs of 570 kW at 28 GHz and 1.1 MW at 77 GHz were obtained corresponding to each design. The operations of more than 750 kW for 5 sec. and 810 kW for 3.5 sec. were achieved in the developing tubes at 77 GHz, which is the first high power-long pulse result of the 77 GHz tube. The experimental simulation of the effect of the stray RF in the 28 GHz tube indicates the stray RF is the one of the major causes limiting gyrotron performance. The output of more than 1 MW with 40% oscillation efficiency is expected from the design of the next 28 GHz gyrotron for GAMMA 10. Installation of the polarizer in the transmission line enhanced the performance of the ECH system in GAMMA 10, that is the first result which clearly showed ∼100% X mode excitation is a key to design the efficient fundamental ECH system of strong field side injection in mirror devices. (author)

DISENTANGLING THE ENVIRONMENT OF THE FU ORIONIS CANDIDATE HBC 722 WITH HERSCHEL

International Nuclear Information System (INIS)

Green, Joel D.; Evans, Neal J. II; Merello, Manuel; Pooley, David; Kospal, Agnes; Van Kempen, Tim A.; Van Dishoeck, Ewine; Herczeg, Gregory; Quanz, Sascha P.; Henning, Thomas; Bouwman, Jeroen; Lee, Jeong-Eun; Dunham, Michael M.; Meeus, Gwendolyn; Chen, Jo-Hsin; Guedel, Manuel; Skinner, Stephen L.; Rebull, Luisa M.; Guieu, Sylvain

2011-01-01

We analyze the submillimeter emission surrounding the new FU Orionis-type object, HBC 722. We present the first epoch of observations of the active environs of HBC 722, with imaging and spectroscopy from PACS, SPIRE, and HIFI on board the Herschel Space Observatory, as well as CO J = 2-1 and 350 μm imaging (SHARC-II) with the Caltech Submillimeter Observatory. The primary source of submillimeter continuum emission in the region-2MASS 20581767+4353310-is located 16'' south-southeast of the optical flaring source while the optical and near-infrared emission is dominated by HBC 722. A bipolar outflow extends over HBC 722; the most likely driver is the submillimeter source. We detect warm (100 K) and hot (246 K) CO emission in the surrounding region, evidence of outflow-driven heating in the vicinity. The region around HBC 722 itself shows little evidence of heating driven by the new outbursting source itself.

Advances in High Power Calorimetric Matched Loads for Short Pulses and CW Gyrotrons

International Nuclear Information System (INIS)

Bin, W.M.; Bruschi, A.; Cirant, S.; Gandini, F.; Granucci, G.; Mellera, V.; Muzzini, V.; Nardone, A.; Sozzi, C.; Spinicchia, N.

2006-01-01

The development of high power gyrotrons for plasma physics research needs proper matched and calorimetric loads able to absorb and measure the power, which nowadays is foreseen to be as high as 2 MW during CW operations. To this end IFP/CNR has developed a family of matched loads useful in the mm-wave frequency band for applications ranging from a few ms to CW in pulse length. The different loads in the family, made of an integrating sphere with a partially reflecting coating on the inner wall, are characterized by having the same absorbing geometry for the incoming beam and a different heat removal system for the specific application. Some important advances have been recently achieved from the point of view of the uniformity of power distribution on the absorbing wall and of the load construction. With high precision achieved in the coating thickness a better control of the heating power distribution is possible by proper shaping of the local reflectivity, in addition to the shaping of the mirror dispersing the input beam. A more sophisticated model describing the power distribution has been developed, taking into account a variable thickness of the absorbing coating, the proper shape of the spreading mirror, the frequency of the incoming radiation and the shape of the input beam. Lower coating thickness is shown to be preferable, at equal local reflectivity, from the point of view of a lower peak temperature and thermal stress. The paper describes a load with variable coating thickness along the meridian of the sphere, showing a uniform power deposition on the inner walls. The cooling pipe is completely electroformed on the spherical copper shell, ensuring the maintenance of the correct curvature of the inner surface and a fast heat conduction from the absorbing coating to the water through the thin copper body. For CW use all heated parts of the load must be cooled and this is achieved by 16 electroformed spiral channels. Both short pulse loads (0.1-1 s) and

Everybody was Kung-Fu fighting-The beneficial effects of Tai Chi Qigong and self-defense Kung-Fu training on psychological and endocrine health in middle aged and older men.

Science.gov (United States)

Walther, A; Lacker, T J; Ehlert, U

2018-02-01

Higher age is associated to a variety of physical and mental disorders. Age-related changes in steroid secretion have been suggested to be an underlying mechanism leading to frailty, depression, and sexual dysfunction. However, Tai chi qigong and similar forms of exercise have been shown to improve a great variety of health-related parameters in older individuals. We examined 56 self-reporting healthy men actively practicing Tai chi qigong and/or self-defense Kung-fu and 55 age-matched self-reporting healthy controls. Saliva samples were obtained in a standardized procedure for subsequent quantification of circulating testosterone and cortisol levels. In addition, depressive symptoms, life satisfaction, and sexual health were assessesd via self-report questionnaires. Age was negatively associated with testosterone, while no association emerged for cortisol. Tai chi qigong and/or self-defense Kung-fu training was neither associated with testosterone nor cortisol. More weekly Tai chi qigong and/or self-defense Kung-fu training (4 or more times per week) was instead associated with a lower CT-ratio, less depressive symptoms, and higher life satisfaction compared to individuals, who trained only one to three times per week. More years of Tai chi qigong and/or self-defense Kung-fu training were associated with less depressive symptoms and higher life satisfaction but not with the CT-ratio. No significant associations emerged for Tai chi qigong and/or self-defense Kung-fu training and sexual health. When compared to the age-matched controls, there is a significant effect of Tai chi, qigong and/or self-defense Kung-fu on the CT-ratio. Contrast analyses revealed a significantly lower CT-ratio for the high training load group in contrast to the low training load group. Further, in contrast to the control group, the low training load group exhibits a significantly higher CT-ratio. For depression, contrast analyses revealed a significantly lower level of depression in the

Development program for a 200 kW, cw gyrotron. Quarterly report No. 11, January-March 1982

International Nuclear Information System (INIS)

Tancredi, J.J.; Caplan, M.; Sandoval, J.J.; Matranga, V.A.

1982-01-01

The objective of this program is the design and development of a millimeter wave device to produce 200 kW of continuous-wave power at 60 GHz. The device, a gyrotron oscillator, will be compatible with power delivery to an electron-cyclotron plasma. Smooth control of RF power output over a 17 dB range is required, and the device should be capable of operation into a severe time-varying load mismatch. During this report period, the beam instability problem which plagued S/N 1 testing was evaluated in more detail. Separate tests were conducted on the gun tester and the lossy drift section, as well as both of these combined, and the results were compared to gyrotron tests on S/N 1. The instability problem now appears to be associated with RF leakage from the cavity

Experimental study of a 1 MW, 170 GHz gyrotron oscillator

Science.gov (United States)

Kimura, Takuji

A detailed experimental study is presented of a 1 MW, 170 GHz gyrotron oscillator whose design is consistent with the ECH requirements of the International Thermonuclear Experimental Reactor (ITER) for bulk heating and current drive. This work is the first to demonstrate that megawatt power level at 170 GHz can be achieved in a gyrotron with high efficiency for plasma heating applications. Maximum output power of 1.5 MW is obtained at 170.1 GHz in 85 kV, 50A operation for an efficiency of 35%. Although the experiment at MIT is conducted with short pulses (3 μs), the gyrotron is designed to be suitable for development by industry for continuous wave operation. The peak ohmic loss on the cavity wall for 1 MW of output power is calculated to be 2.3 kW/cm2, which can be handled using present cooling technology. Mode competition problems in a highly over-moded cavity are studied to maximize the efficiency. Various aspects of electron gun design are examined to obtain high quality electron beams with very low velocity spread. A triode magnetron injection gun is designed using the EGUN simulation code. A total perpendicular velocity spread of less than 8% is realized by designing a low- sensitivity, non-adiabatic gun. The RF power is generated in a short tapered cavity with an iris step. The operating mode is the TE28,8,1 mode. A mode converter is designed to convert the RF output to a Gaussian beam. Power and efficiency are measured in the design TE28,8,1 mode at 170.1 GHz as well as the TE27,8,1 mode at 166.6 GHz and TE29,8,1 mode at 173.5 GHz. Efficiencies between 34%-36% are consistently obtained over a wide range of operating parameters. These efficiencies agree with the highest values predicted by the multimode simulations. The startup scenario is investigated and observed to agree with the linear theory. The measured beam velocity ratio is consistent with EGUN simulation. Interception of reflected beam by the mod-anode is measured as a function of velocity ratio

Operation of a quasi-optical gyrotron with a gaussian output coupler

Energy Technology Data Exchange (ETDEWEB)

Hogge, J.P.; Tran, T.M.; Paris, P.J.; Tran, M.Q. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP)

1996-03-01

The operation of a 92 GHz quasi-optical gyrotron (QOG) having a resonator formed by a spherical mirror and a diffraction grating placed in -1 order Littrow mount is presented. A power of 150 kW with a gaussian output pattern was measured. The gaussian content in the output was 98% with less than 1% of depolarization. By optimizing the magnetic field at fixed frequency, a maximum efficiency of 15% was reached. (author) 12 figs., 2 tabs., 22 refs.

Characteristic patients with oral mucositis receiving 5-FU chemotherapy at Hasan Sadikin Hospital Bandung

Directory of Open Access Journals (Sweden)

Syarifah Fatimah

2016-11-01

Full Text Available Introduction: Oral mucositis is an inflammatory reaction of oral mucous membrane that often appears in cancer patients due to the chemotherapeutic agents, such as 5-fluorouracil (5-FU. The aim of this study was to describe the characteristic patients who receive 5-FU and had oral mucositis. Methods: This study was conducted on 41 patients with cancer receiving 5-FU chemotherapy at Dr Hasan Sadikin Hospital Bandung. The data was retrieved through interviews to find out patient’s characteristic; nutritional status examination by using body mass index measurement; and oral examination. Severity level was determined by using National Cancer Institute’s Common Toxicity Criteria scale, and the level of pain was measured by Numeric Pain Intensity Rating scale. Results: This research have shown 60,98% patient with cancer had received 5-FU chemotherapy treatment, and 44% with poor nutritional status (underweight. Oral mucositis was only found at non-keratinised mucous. The finding of this study was patients that receiving 5-FU chemotherapy treatment diagnosed with oral mucositis was on the 1st stadium (52% and the 2nd stadium (44% with the level of pain was on the mild level (48% and moderate level (32%.Conclusion: Oral mucositis was found on patients with cancer that received 5-FU chemotherapy with a variety of characteristics, nutritional statuses, locations, levels of severity and pain.

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.

Science.gov (United States)

Tukachinsky, Hanna; Lopez, Lyle V; Salic, Adrian

2010-10-18

In vertebrates, Hedgehog (Hh) signaling initiated in primary cilia activates the membrane protein Smoothened (Smo) and leads to activation of Gli proteins, the transcriptional effectors of the pathway. In the absence of signaling, Gli proteins are inhibited by the cytoplasmic protein Suppressor of Fused (SuFu). It is unclear how Hh activates Gli and whether it directly regulates SuFu. We find that Hh stimulation quickly recruits endogenous SuFu-Gli complexes to cilia, suggesting a model in which Smo activates Gli by relieving inhibition by SuFu. In support of this model, we find that Hh causes rapid dissociation of the SuFu-Gli complex, thus allowing Gli to enter the nucleus and activate transcription. Activation of protein kinase A (PKA), an inhibitor of Hh signaling, blocks ciliary localization of SuFu-Gli complexes, which in turn prevents their dissociation by signaling. Our results support a simple mechanism in which Hh signals at vertebrate cilia cause dissociation of inactive SuFu-Gli complexes, a process inhibited by PKA.

Galactosylated nanostructured lipid carriers for delivery of 5-FU to hepatocellular carcinoma.

Science.gov (United States)

Varshosaz, Jaleh; Hassanzadeh, Farshid; Sadeghi, Hojjat; Khadem, Mostafa

2012-09-01

The aim of the present study was to design a targeted delivery system of 5-fluorouracil (5-FU) for hepatocellular carcinoma (HCC). Lactobionic acid (LB) was conjugated to stearyl amine (SA) by a chemical reaction. The nanostructured lipid carriers (NLCs), containing LB conjugate, lecithin, glyceryl monostearate, oil [oleic acid (OA) or Labrafac 5 or 10%], and 5-FU, were dissolved in alcohol/acetone, the oil phase was added to the aqueous phase containing Tween 80 or Solutol(®) HS15 (0.25 or 0.5%), and NLCs were prepared by an emulsification-solvent diffusion method. Physical properties and drug release were studied in NLCs. The thiazolyl blue tetrazolium bromide assay was used to study the cytotoxicity of NLCs on HepG(2) cells, and the cellular uptake of NLCs was determined by flow cytometry. Fourier transform infrared spectroscopy and (1)H-NMR spectra confirmed the successful conjugation of LB and SA. The optimized NLCs consisted of 0.5% Solutol HS15 and 10% OA oil. The particle size of these nanoparticles was 139.2 nm, with a zeta potential of -18 mV, loading efficiency of 34.2%, release efficiency after 2 hours of the release test was 72.6%, and crystallinity was 0.63%. The galactosylated NLCs of 5-FU were cytotoxic on the HepG(2) cell line in a half concentration of 5-FU and seems promising in reducing 5-FU dose in HCC.

Numerical Simulation of a Double-anode Magnetron Injection Gun for 110 GHz, 1 MW Gyrotron

Science.gov (United States)

Singh, Udaybir; Kumar, Nitin; Purohit, L. P.; Sinha, Ashok K.

2010-07-01

A 40 A double-anode magnetron injection gun for a 1 MW, 110 GHz gyrotron has been designed. The preliminary design has been obtained by using some trade-off equations. The electron beam analysis has been performed by using the commercially available code EGUN and the in-house developed code MIGANS. The operating mode of the gyrotron is TE22,6 and it is operated in the fundamental harmonic. The electron beam with a low transverse velocity spread ( δ {β_{ bot max }} = 2.26% ) and the transverse-to-axial velocity ratio of the electron beam (α) = 1.37 is obtained. The simulated results of the MIG obtained with the EGUN code have been validated with another trajectory code TRAK. The results on the design output parameters obtained by both the codes are in good agreement. The sensitivity analysis has been carried out by changing the different gun parameters to decide the fabrication tolerance.

First experimental results of the LAP/INPE (Plasma Associated Lab) gyrotron

International Nuclear Information System (INIS)

Barroso, J.J.; Rossi, J.O.; Castro, P.J.; Correa, R.A.; Montes, A.; Ludwig, G.O.; Idehara, T.; Ogawa, I.

1994-01-01

The design and operation of a high power pulsed gyrotron are reported. A magnetron injection gun generates a 5 A, 50 keV helical laminar electron beam with a pitch ratio of 1.5. The electron beam is then placed on the second radial maximum of the T E 02 nominal mode in the resonant cavity. The magnet system comprises three independent water-cooled solenoids located in the gun, cavity and collector regions, consisting of split pair magnets with the field direction vertical. The resonator is a weakly tapered waveguide with a straight section of 0.5 cm in length, a down taper angle of 0.8 0 and an up taper angle of 5 0 The gyrotron runs in pulsed regime with a 20μs pulse length at a frequency repetition rate of 10 Hz and during operation the pressure in the tube is ordinarily less than 4.0 X 10 -7 Torr. Several TE modes were detected over the magnetic field range 9.5 to 12.5 kG and the measured resonant frequencies (29.0 to 32.0 GHz) showed to be in close agreement with the self-consistent calculated values. Experiments are currently under way to measure the absolute output power and to identify the modes through field pattern measurement techniques. (author). 3 refs, 3 figs

Pre-operative combined 5-FU, low dose leucovorin, and sequential radiation therapy for unresectable rectal cancer

International Nuclear Information System (INIS)

Minsky, B.D.; Cohen, A.M.; Kemeny, N.; Enker, W.E.; Kelsen, D.P.; Schwartz, G.; Saltz, L.; Dougherty, J.; Frankel, J.; Wiseberg, J.

1993-01-01

The authors performed a Phase 1 trial to determine the maximum tolerated dose of combined pre-operative radiation (5040 cGy) and 2 cycles (bolus daily x 5) of 5-FU and low dose LV (20 mg/m2), followed by surgery and 10 cycles of post-operative LV/5-FU in patients with unresectable primary or recurrent rectal cancer. Twelve patients were entered. The initial dose of 5-FU was 325 mg/m2. 5-FU was to be escalated while the LV remained constant at 20 mg/m2. Chemotherapy began on day 1 and radiation on day 8. The post-operative chemotherapy was not dose escalated; 5-FU: 425 mg/m2 and LV: 20 mg/m2. The median follow-up was 14 months (7--16 months). Following pre-operative therapy, the resectability rate with negative margins was 91% and the pathologic complete response rate was 9%. For the combined modality segment (preoperative) the incidence of any grade 3+ toxicity was diarrhea: 17%, dysuria: 8%, mucositis: 8%, and erythema: 8%. The median nadir counts were WBC: 3.1, HGB: 8.8, and PLT: 153000. The maximum tolerated dose of 5-FU for pre-operative combined LV/5-FU/RT was 325 mg/m2 with no escalation possible. Therefore, the recommended dose was less than 325 mg/m2. Since adequate doses of 5-FU to treat systemic disease could not be delivered until at least 3 months (cycle 3) following the start of therapy, the authors do not recommend that this 5-FU, low dose LV, and sequential radiation therapy regimen be used as presently designed. However, given the 91% resectability rate they remain encouraged with this approach. 31 refs., 1 fig., 2 tabs

Development of over-1 MW gyrotrons for the LHD and the GAMMA 10 ECH systems

International Nuclear Information System (INIS)

Imai, T.; Kariya, T.; Minami, R.

2010-11-01

For the ECH upgrade program of LHD and GAMMA10, over-1 MW power gyrotrons have been developed in the joint program of NIFS and University of Tsukuba. The gyrotrons for LHD and GAMMA 10 have TE 18,6 cavity and a diamond window at 77 GHz, and with TE 8,3 cavity at 28 GHz, respectively. The maximum outputs obtained are 1.9 MW for 0.1 s on the 77 GHz LHD tube and ∼ 1 MW on the 28 GHz one, which are the new records in these frequency ranges. The results of 1.8 MW for 1 s, 1.6 MW for 1.8s, 1 MW for 5 s, 300 kW for 40 min and 200 kW for 75 min were achieved at 77 GHz. In the long pulse operation, it is found that the stray RF is the major cause limiting the pulse length. Design improvements of the diffraction loss, the cavity and pitch factor α (=v sub(perpendicular)/v sub(parallel)) dispersion of the MIG have made the 77 GHz tube performance better, which have enabled to demonstrate 1.9 MW output and long pulse operation for more than 1 hour with 200 kW. The three 77 GHz gyrotrons have already been installed in the LHD ECH system and more than 3 MW has been injected into LHD plasma. In the 28 GHz long pulse operation, 400 kW for 1 sec has been obtained and it is found the higher and longer pulse operation would be possible with the operation optimization and conditioning. (author)

[Professor Xu Fu-song's traditional Chinese medicine protocols for male diseases: A descriptive analysis].

Science.gov (United States)

Liu, Cheng-yong; Xu, Fu-song

2015-04-01

To analyze the efficacy and medication principles of Professor Xu Fu-songs traditional Chinese medicine (TCM) protocols for male diseases. We reviewed and descriptively analyzed the unpublished complete medical records of 100 male cases treated by Professor Xu Fu-song with his TCM protocols from 1978 to 1992. The 100 cases involved 32 male diseases, most of which were difficult and complicated cases. The drug compliance was 95%. Each prescription was made up of 14 traditional Chinese drugs on average. The cure rate was 32% , and the effective rate was 85%. Professor Xu Fu-song advanced and proved some new theories and therapeutic methods. Professor Xu Fu-song's TCM protocols can be applied to a wide range of male diseases, mostly complicated, and are characterized by accurate differentiation of symptoms and signs, high drug compliance, and excellent therapeutic efficacy.

Chemoradiotherapy using platinum analogs/5-FU for advanced esophageal cancer

International Nuclear Information System (INIS)

Shibata, Shigeru; Kawasaki, Hitoshi; Nakai, Makoto; Morohashi, Hajime; Matsuya, Hideki; Yamada, Kyougo; Morita, Takayuki; Sasaki, Mutsuo

2002-01-01

We evaluated the efficacy of concurrent chemoradiotherapy (CRT) using cisplatin/nedaplatin and 5-fluorouracil (5-FU) for advanced esophageal cancer. Thirteen patients with locally advanced esophageal cancer (T4 cases) and 3 with recurrence of esophageal cancer were treated with radiotherapy (40-70 Gy) and 5-FU combined and cisplatin/nedaplatin concurrently. T4 patients who obtained down-staging by CRT also underwent esophagectomy. A complete response was obtained in one case, partial response in 8 cases, and no change in 7 cases. The overall response rate was 56.3%. A pathological complete response was obtained in one case in which curative resection was performed after CRT. Bone marrow suppression was observed in 68.8% and grade 3 and 4 bone marrow suppression was observed in 43.8%. Concurrent CRT using cisplatin/nedaplatin and 5-FU for advanced esophageal cancer has a high response rate and patients obtaining down-staging by CRT as a neoadjuvant therapy have a chance for long survival after curative resection in locally advanced cases. (author)

Gyrotron development at the Instituto de Pesquisas Espaciais

International Nuclear Information System (INIS)

Barroso, J.J.; Castro, P.J. de; Correa, R.A.; Galvao, G.P.; Ludwig, G.O.; Montes, A.; Nono, M.C.A.

1987-07-01

The conceptual design of a 35GHz gyrotron operating in the TE 01 mode, intended for plasma heating experiments, is presented. The electrooptical system is sinthesized from electron beam parameters in the cavity region and the electrodynamical system includes a conventional resonator consisting of truncated cones. The starting and operating characteristics are calculated by integrating the exact equation of electron motion under de action of an RF field with fixed spatial distribution. The experimental activities are concentrated on the construction of a system of magnetic coils, able to generate a 15 KG magnetic induction with a fluctuation of 0.1% over an extension of 13 cm; the manufacture of caerties by using electroforming techniques; and the development of techiques for the construction of electron guns. (author) [pt

High-Resolution Near-Infrared Spectroscopy of FU Orionis Objects

Science.gov (United States)

Hartmann, Lee; Hinkle, Kenneth; Calvet, Nuria

2004-07-01

We present an analysis of recent near-infrared, high-resolution spectra of the variable FU Ori objects. During a phase of rapid fading in optical brightness during 1997, V1057 Cyg exhibited shell absorption in first-overtone (v''-v'=2-0) CO lines, blueshifted by about 50 km s-1 from the system velocity. This shell component had not been seen previously, nor was it present in 1999, although some blueshifted absorption asymmetry is seen at the latter epoch. The appearance of this CO absorption shell is connected with the roughly contemporaneous appearance of blueshifted, low-excitation optical absorption lines with comparable low velocities; we suggest that this shell was also responsible for some of the peculiar emission features seen in red-optical spectra of V1057 Cyg. FU Ori continues to exhibit broad CO lines, with some evidence for the double-peaked profiles characteristic of an accretion disk; the line profiles are consistent with previous observations. Both FU Ori and V1057 Cyg continue to exhibit lower rotational broadening at 2.3 μm than at optical wavelengths, in agreement with the prediction of differentially rotating disk models; we have a marginal detection of the same effect in V1515 Cyg. The relative population of the first-overtone CO rotational levels in the FU Ori objects suggests low excitation temperatures. We compare disk models to the observations and find agreement with overall line strengths and rotational broadening, but the observed line profiles are generally less double-peaked than predicted. We suggest that the discrepancy in line profiles is due to turbulent motions in FU Ori disks, an effect qualitatively predicted by recent simulations of the magnetorotational instability in vertically stratified accretion disks. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy (AURA), Inc., under a cooperative agreement with the NSF, on behalf of the Gemini

Teaching Tu Fu on the Night Shift.

Science.gov (United States)

Brady, Philip

1995-01-01

Describes a teacher's unsuccessful attempt to introduce the poetry of Tu Fu, a wayward bureaucrat of the T'ang dynasty, to a class of part-time students. Uses his students' resistance to this poetry as an occasion to discuss the importance of personal responses to poetry, as opposed to "correct" academic responses. (TB)

Study of a high-order-mode gyrotron traveling-wave amplifier

International Nuclear Information System (INIS)

Chiu, C. C.; Tsai, C. Y.; Kao, S. H.; Chu, K. R.; Barnett, L. R.; Luhmann, N. C. Jr.

2010-01-01

Physics and performance issues of a TE 01 -mode gyrotron traveling-wave amplifier are studied in theory. For a high order mode, absolute instabilities on neighboring modes at the fundamental and higher cyclotron harmonic frequencies impose severe constraints to the device capability. Methods for their stabilization are outlined, on the basis of which the performance characteristics are examined in a multidimensional parameter space under the marginal stability criterion. The results demonstrate the viability of a high-order-mode traveling-wave amplifier and provide a roadmap for design tradeoffs among power, bandwidth, and efficiency. General trends are observed and illustrated with specific examples.

Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

Science.gov (United States)

Chen, Lijue; She, Xiaodong; Wang, Tao; He, Li; Shigdar, Sarah; Duan, Wei; Kong, Lingxue

2015-08-01

Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The effect and mechanism of 5-FU loaded EGF grafted HMSNs (EGF-HMSNs-5-FU) in overcoming acquired drug resistance in SW480/ADR cells were studied. The EGF-HMSNs were demonstrated to be specifically internalized in EGFR overexpressed SW480/ADR cells via a receptor-mediated endocytosis and can escape from endo-lysosomes. The EGF-HMSNs-5-FU exhibited much higher cytotoxicity on SW480/ADR cells than HMSNs-5-FU and free 5-FU while the plain HMSNs did not show significant cytotoxicity. The mechanism of EGF-HMSNs-5-FU in overcoming drug resistance in SW480/ADR cells could be attributed to the specific internalization of EGF-HMSNs-5-FU in EGFR overexpressed cells which can lead to high intracellular drug accumulation and cause cell death through S phase arrest.Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The

Wheat germ agglutinin-functionalised crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU

DEFF Research Database (Denmark)

Glavas-Dodov,, Marija; Steffansen, Bente; Srcarevska, Maja

2013-01-01

We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential of these......We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential......-Ca-ALG MPs and WGA conjugates. The concentration of 5-FU associated with Caco-2 cells was significantly greater when delivered from MPs. By incorporation of 5-FU into MPs and further decoration with WGA, an increased [methyl-³H]thymidine uptake was observed few hours after continuous drug treatment followed...... by significantly reduced uptake after 6 h. Gastrointestinal distribution was in favour of increased localisation and concentration of the particles in colon region....

Design of 28 GHz, 200 kW Gyrotron for ECRH Applications

Science.gov (United States)

Yadav, Vivek; Singh, Udaybir; Kumar, Nitin; Kumar, Anil; Deorani, S. C.; Sinha, A. K.

2013-01-01

This paper presents the design of 28 GHz, 200 kW gyrotron for Indian TOKAMAK system. The paper reports the designs of interaction cavity, magnetron injection gun and RF window. EGUN code is used for the optimization of electron gun parameters. TE03 mode is selected as the operating mode by using the in-house developed code GCOMS. The simulation and optimization of the cavity parameters are carried out by using the Particle-in-cell, three dimensional (3-D)-electromagnetic simulation code MAGIC. The output power more than 250 kW is achieved.

Recent operating experience with Varian 70 GHz and 140 GHz gyrotrons

International Nuclear Information System (INIS)

Felch, K.; Bier, R.; Fox, L.; Huey, H.; Ives, L.; Jory, H.; Lopez, N.; Shively, J.; Spang, S.

1985-01-01

The design features and initial test results of Varian 70 GHz and 140 GHz CW gyrotrons are presented. The first experimental 140 GHz tube has achieved an output power of 102 kW at 24% efficiency under pulsed conditions in the desired TE 031 0 cavity mode. Further tests aimed at achieving the design goal of 100 kW CW are currently underway. The 70 GHz tube has achieved an output power of 200 kW under pulsed conditions and possesses a wide dynamic range for output power variations. 6 refs., 8 figs

Advantages of using gyrotron scattering for alpha particle diagnostics

International Nuclear Information System (INIS)

Woskoboinikow, P.P.; Cohn, D.R.; Machuzak, J.S.; Myer, R.C.; Rhee, R.Y.

1987-07-01

Millimeter-wave gyrotron collective Thomson scattering can be an effective diagnostic technique for the study of alpha particle behavior in ignited plasmas. The measurement of alpha particle density, velocity distribution, and alpha particle induced plasma instabilities can be accomplished with both spatial and temporal resolution. Advantages include long pulse operation which can make possible very high signal to noise ratios and use of millimeter waves which maximizes the Doppler shifted scattered signal in WHz -1 and makes possible scattering angles up to 180 0 . Extraordinary mode scattering at approximately 60 and 200 GHz would be used in TFTR and CIT respectively, and 140 GHz ordinary mode scattering in JET. 8 refs., 1 fig

Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm.

Directory of Open Access Journals (Sweden)

Mei Peng

Full Text Available Although 5-fluorouracil (5-Fu combination chemotherapy provides a satisfactory therapeutic response in patients with gestational trophoblastic neoplasms (GTNs, it has severe side effects. The current study analyzed the therapeutic effects and side effects of tegafur plus actinomycin D (Act-D vs. 5-Fu plus Act-D for the treatment of GTNs based on controlled historical records. A total of 427 GTN cases that received tegafur and Act-D combination chemotherapy at the Second Xiangya Hospital of XiangYa Medical School between August 2003 and July 2013 were analyzed based on historical data. A total of 393 GTN cases that received 5-Fu plus Act-D between August 1993 and July 2003 at the same hospital were also analyzed, which constituted the control group. The therapeutic effects, toxicity and side effects after chemotherapy were compared between the groups. The overall response rate was 90.63% in the tegafur+Act-D group (tegafur group and 92.37% in the 5-Fu+Act-D group (5-Fu group; these rates were not significantly different (P > 0.05. However, the incidence rates of myelosuppression (white blood cell decline, gastrointestinal reactions (nausea, vomiting, dental ulcer, and diarrhea, skin lesions and phlebitis were lower in the tegafur group than in the 5-Fu group (P < 0.05. The results of this study may provide useful data for the clinical application of tegafur in GTN treatment.

Advanced Output Coupling for High Power Gyrotrons

Energy Technology Data Exchange (ETDEWEB)

Read, Michael [Calabazas Creek Research, Inc., San Mateo, CA (United States); Ives, Robert Lawrence [Calabazas Creek Research, Inc., San Mateo, CA (United States); Marsden, David [Calabazas Creek Research, Inc., San Mateo, CA (United States); Collins, George [Calabazas Creek Research, Inc., San Mateo, CA (United States); Temkin, Richard [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Guss, William [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Lohr, John [General Atomics, La Jolla, CA (United States); Neilson, Jeffrey [Lexam Research, Redwood City, CA (United States); Bui, Thuc [Calabazas Creek Research, Inc., San Mateo, CA (United States)

2016-11-28

The Phase II program developed an internal RF coupler that transforms the whispering gallery RF mode produced in gyrotron cavities to an HE11 waveguide mode propagating in corrugated waveguide. This power is extracted from the vacuum using a broadband, chemical vapor deposited (CVD) diamond, Brewster angle window capable of transmitting more than 1.5 MW CW of RF power over a broad range of frequencies. This coupling system eliminates the Mirror Optical Units now required to externally couple Gaussian output power into corrugated waveguide, significantly reducing system cost and increasing efficiency. The program simulated the performance using a broad range of advanced computer codes to optimize the design. Both a direct coupler and Brewster angle window were built and tested at low and high power. Test results confirmed the performance of both devices and demonstrated they are capable of achieving the required performance for scientific, defense, industrial, and medical applications.

THE MID-INFRARED EVOLUTION OF THE FU ORIONIS DISK

Energy Technology Data Exchange (ETDEWEB)

Green, Joel D.; Jones, Olivia C.; Poteet, Charles A.; Sargent, Benjamin A. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Keller, Luke D. [Department of Physics and Astronomy, Ithaca College, Ithaca, NY (United States); Yang, Yao-Lun; Evans II, Neal J. [Department of Astronomy, The University of Texas at Austin, Austin, TX 78712 (United States); Fischer, William J. [Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Rebull, Luisa M. [IPAC, Pasadena, CA 91125 (United States)

2016-11-20

We present new SOFIA-FORCAST observations obtained in 2016 February of the archetypal outbursting low-mass young stellar object FU Orionis, and we compare the continuum, solid-state, and gas properties with mid-infrared data obtained at the same wavelengths in 2004 with Spitzer -IRS. In this study, we conduct the first mid-infrared spectroscopic comparison of an FUor over a long time period. Over a 12-year period, UBVR monitoring indicates that FU Orionis has continued its steady decrease in overall brightness by ∼14%. We find that this decrease in luminosity occurs only at wavelengths ≲20 μ m. In particular, the continuum shortward of the silicate emission complex at 10 μ m exhibits a ∼12% (∼3 σ ) drop in flux density but no apparent change in slope; both the Spitzer and SOFIA spectra are consistent with a 7200 K blackbody. Additionally, the detection of water absorption is consistent with the Spitzer spectrum. The silicate emission feature at 10 μ m continues to be consistent with unprocessed grains, unchanged over 12 years. We conclude that either the accretion rate in FU Orionis has decreased by ∼12–14% over this time baseline or the inner disk has cooled, but the accretion disk remains in a superheated state outside the innermost region.

MULTIWAVELENGTH OBSERVATIONS OF V2775 Ori, AN OUTBURSTING PROTOSTAR IN L 1641: EXPLORING THE EDGE OF THE FU ORIONIS REGIME

Energy Technology Data Exchange (ETDEWEB)

Fischer, William J.; Megeath, S. Thomas; Kounkel, Marina [Department of Physics and Astronomy, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606 (United States); Tobin, John J. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Stutz, Amelia M.; Henning, Thomas [Max-Planck-Institut fuer Astronomie, Koenigstuhl 17, D-69117 Heidelberg (Germany); Ali, Babar [NHSC/IPAC/Caltech, 770 South Wilson Avenue, Pasadena, CA 91125 (United States); Remming, Ian; Manoj, P. [Department of Physics and Astronomy, 500 Wilson Boulevard, University of Rochester, Rochester, NY 14627 (United States); Stanke, Thomas [ESO, Karl-Schwarzschild-Strasse 2, D-85748 Garching bei Muenchen (Germany); Osorio, Mayra [Instituto de Astrofisica de Andalucia, CSIC, Camino Bajo de Huetor 50, E-18008, Granada (Spain); Wilson, T. L., E-mail: wfische@utnet.utoledo.edu [Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375 (United States)

2012-09-01

Individual outbursting young stars are important laboratories for studying the physics of episodic accretion and the extent to which this phenomenon can explain the luminosity distribution of protostars. We present new and archival data for V2775 Ori (HOPS 223), a protostar in the L 1641 region of the Orion molecular clouds that was discovered by Caratti o Garatti et al. to have recently undergone an order-of-magnitude increase in luminosity. Our near-infrared spectra of the source have strong blueshifted He I {lambda}10830 absorption, strong H{sub 2}O and CO absorption, and no H I emission, all typical of FU Orionis sources. With data from the Infrared Telescope Facility, the Two Micron All Sky Survey, the Hubble Space Telescope, Spitzer, the Wide-field Infrared Survey Explorer, Herschel, and the Atacama Pathfinder Experiment that span from 1 to 70 {mu}m pre-outburst and from 1 to 870 {mu}m post-outburst, we estimate that the outburst began between 2005 April and 2007 March. We also model the pre- and post-outburst spectral energy distributions of the source, finding it to be in the late stages of accreting its envelope with a disk-to-star accretion rate that increased from {approx}2 Multiplication-Sign 10{sup -6} M{sub Sun} yr{sup -1} to {approx}10{sup -5} M{sub Sun} yr{sup -1} during the outburst. The post-outburst luminosity at the epoch of the FU Orionis-like near-IR spectra is 28 L{sub Sun }, making V2775 Ori the least luminous documented FU Orionis outburster with a protostellar envelope. The existence of low-luminosity outbursts supports the notion that a range of episiodic accretion phenomena can partially explain the observed spread in protostellar luminosities.

Infection witb'l\\:fued GastrointestinafNematOde Parasites ',' .:

African Journals Online (AJOL)

Resistance of Three Strains 'of Sinall EasL~friCan 'Goats to Artificial. Infection witb'l\\:fued ... TWC and mortality among the SEA gOat strains, Gogo goats had significantly lower FEC (606 ejJg). ]WC (529) and .... Chi-square test. This involved ...

FuGeF: A Resource Bound Secure Forwarding Protocol for Wireless Sensor Networks.

Science.gov (United States)

Umar, Idris Abubakar; Mohd Hanapi, Zurina; Sali, A; Zulkarnain, Zuriati A

2016-06-22

Resource bound security solutions have facilitated the mitigation of spatio-temporal attacks by altering protocol semantics to provide minimal security while maintaining an acceptable level of performance. The Dynamic Window Secured Implicit Geographic Forwarding (DWSIGF) routing protocol for Wireless Sensor Network (WSN) has been proposed to achieve a minimal selection of malicious nodes by introducing a dynamic collection window period to the protocol's semantics. However, its selection scheme suffers substantial packet losses due to the utilization of a single distance based parameter for node selection. In this paper, we propose a Fuzzy-based Geographic Forwarding protocol (FuGeF) to minimize packet loss, while maintaining performance. The FuGeF utilizes a new form of dynamism and introduces three selection parameters: remaining energy, connectivity cost, and progressive distance, as well as a Fuzzy Logic System (FLS) for node selection. These introduced mechanisms ensure the appropriate selection of a non-malicious node. Extensive simulation experiments have been conducted to evaluate the performance of the proposed FuGeF protocol as compared to DWSIGF variants. The simulation results show that the proposed FuGeF outperforms the two DWSIGF variants (DWSIGF-P and DWSIGF-R) in terms of packet delivery.

Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters.

Science.gov (United States)

Ribeiro, Susana Barbosa; de Araújo, Aurigena Antunes; Araújo Júnior, Raimundo Fernandes de; Brito, Gerly Anne de Castro; Leitão, Renata Carvalho; Barbosa, Maisie Mitchele; Garcia, Vinicius Barreto; Medeiros, Aldo Cunha; Medeiros, Caroline Addison Carvalho Xavier de

2017-01-01

Oral mucositis (OM) is an important side effect of cancer treatment, characterized by ulcerative lesions in the mucosa of patients undergoing radiotherapy or chemotherapy, which has marked effects on patient quality of life and cancer therapy continuity. Considering that few protocols have demonstrated efficacy in preventing this side effect, the aim of this study was to examine the effect of dexamethasone (DEX) on OM induced by 5-fluorouracil (5-FU) in hamsters by studying signaling pathways. OM was induced in hamsters by 5-FU followed by mechanical trauma (MT) on day 4. On day 10, the animals were euthanized. The experimental groups included saline, MT, 5-FU, and DEX (0.25, 0.5, or 1 mg/kg). Macroscopic, histopathological, and immunohistochemical analyses as well as immunofluorescence experiments were performed on the oral mucosa of the animals. The oral mucosal samples were analyzed by enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction (qPCR). DEX (0.5 or 1 mg/kg) reduced inflammation and ulceration of the oral mucosa of hamsters. In addition, DEX (1 mg/kg) reduced the cytokine levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and macrophage migration inhibitory factor (MIF). DEX (1 mg/kg) also reduced the immunoexpression of cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-2, transforming growth factor (TGF)-β, MIF, Smad 2/3, Smad 2/3 phosphorylated and NFκB p65 in the jugal mucosa. Finally, DEX (1 mg/kg) increased interleukin-1 receptor-associated kinase 3 (IRAK-M), glucocorticoid-induced leucine zipper (GILZ), and mitogen-activated protein kinase (MKP1) gene expression and reduced NFκB p65 and serine threonine kinase (AKt) gene expression, relative to the 5-FU group. Thus, DEX improved OM induced by 5-FU in hamsters.

Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters.

Directory of Open Access Journals (Sweden)

Susana Barbosa Ribeiro

Full Text Available Oral mucositis (OM is an important side effect of cancer treatment, characterized by ulcerative lesions in the mucosa of patients undergoing radiotherapy or chemotherapy, which has marked effects on patient quality of life and cancer therapy continuity. Considering that few protocols have demonstrated efficacy in preventing this side effect, the aim of this study was to examine the effect of dexamethasone (DEX on OM induced by 5-fluorouracil (5-FU in hamsters by studying signaling pathways. OM was induced in hamsters by 5-FU followed by mechanical trauma (MT on day 4. On day 10, the animals were euthanized. The experimental groups included saline, MT, 5-FU, and DEX (0.25, 0.5, or 1 mg/kg. Macroscopic, histopathological, and immunohistochemical analyses as well as immunofluorescence experiments were performed on the oral mucosa of the animals. The oral mucosal samples were analyzed by enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction (qPCR. DEX (0.5 or 1 mg/kg reduced inflammation and ulceration of the oral mucosa of hamsters. In addition, DEX (1 mg/kg reduced the cytokine levels of tumor necrosis factor (TNF-α, interleukin (IL-1β, and macrophage migration inhibitory factor (MIF. DEX (1 mg/kg also reduced the immunoexpression of cyclooxygenase (COX-2, matrix metalloproteinase (MMP-2, transforming growth factor (TGF-β, MIF, Smad 2/3, Smad 2/3 phosphorylated and NFκB p65 in the jugal mucosa. Finally, DEX (1 mg/kg increased interleukin-1 receptor-associated kinase 3 (IRAK-M, glucocorticoid-induced leucine zipper (GILZ, and mitogen-activated protein kinase (MKP1 gene expression and reduced NFκB p65 and serine threonine kinase (AKt gene expression, relative to the 5-FU group. Thus, DEX improved OM induced by 5-FU in hamsters.

Development program for a 200-kW, c-w gyrotron. Quarterly report No. 7, January-March 1981

International Nuclear Information System (INIS)

Tancredi, J.J.; Caplan, M.; Sandoval, J.J.; Jordan, E.; Matranga, V.A.

1981-01-01

The objective of this program is the design and development of a millimeter-wave device to produce 200 kW of continuous-wave power at 60 GHz. The device, which will be a gyrotron oscillator, will be compatible with power delivery to an electron-cyclotron plasma. Smooth control of rf power output over a 17 dB range is required, and the device should be capable of operation into a severe time-varying rf load mismatch. An interim program goal is to demonstrate operation at 100 ms pulse widths by 31 December 1981. During this quarter, progress was made in the areas of tube, solenoid, and facility construction. Two magnetron injection gun assemblies were completed, and one was partially evaluated as a gun tester. The superconducting solenoid was assembled, but a vacuum leak prevented early delivery in March. Construction began on the gyrotron test facility by enclosing the area and providing bake-out and vacuum processing utilities

Demonstration of a High-Order Mode Input Coupler for a 220-GHz Confocal Gyrotron Traveling Wave Tube

Science.gov (United States)

Guan, Xiaotong; Fu, Wenjie; Yan, Yang

2018-02-01

A design of high-order mode input coupler for 220-GHz confocal gyrotron travelling wave tube is proposed, simulated, and demonstrated by experimental tests. This input coupler is designed to excite confocal TE 06 mode from rectangle waveguide TE 10 mode over a broadband frequency range. Simulation results predict that the optimized conversion loss is about 2.72 dB with a mode purity excess of 99%. Considering of the gyrotron interaction theory, an effective bandwidth of 5 GHz is obtained, in which the beam-wave coupling efficiency is higher than half of maximum. The field pattern under low power demonstrates that TE 06 mode is successfully excited in confocal waveguide at 220 GHz. Cold test results from the vector network analyzer perform good agreements with simulation results. Both simulation and experimental results illustrate that the reflection at input port S11 is sensitive to the perpendicular separation of two mirrors. It provides an engineering possibility for estimating the assembly precision.

High response rates following paclitaxel/5-FU and simultaneous radiotherapy in advanced head and neck carcinoma; Hohe Remissionsraten unter simultaner Radio- und Chemotherapie mit Paclitaxel/5-FU in der Behandlung fortgeschrittener Kopf-Hals-Tumoren

Energy Technology Data Exchange (ETDEWEB)

Schroeder, M.; Westerhausen, M. [St.-Johannes-Hospital, Duisburg (Germany). Medizinische Klinik II; Makoski, H.B. [Staedtische Kliniken, Duisburg (Germany). Radioonkologie; Sesterhenn, K. [St. Anna-Krankenhaus, Duisburg (Germany). HNO-Klinik; Schroeder, R. [Bristol Myers Squibb, Muenchen (Germany). Dept. of Oncology

1997-11-01

The main stay of treatment for head and neck cancer patients with advanced disease has been chemotherapy with Cisplatin/5-FU and simultaneous applied radiotherapy. With this multimodality treatment including radical surgery after two cycles of neoadjuvant chemotherapy and 40 Gy radiotherapy we reported 60% complete remission after 5 years for patients with stage III/IV of head and neck cancer. Paclitaxel, a new plant product, has demonstrated significant antineoplastic activity in head and neck tumors (ECOG-Study: 40% RR). Therefore we performed a trial with Taxol/5-FU and simultaneous radiation in a neoadjuvant and postoperative adjuvant setting of stage III/IV squamous cell carcinoma of the head and neck with pre-existent contraindication against Cisplatin. Patients and Methods: 30 patients with a primarily inoperable stage III/IV of SCC of the head and neck were enrolled to receive day 1 and 29 Taxol 175 mg/m{sup 2} as a 3-hour-infusion, followed by 120-hour-cvi of 1000 mg/m{sup 2}/d 5-FU. Locally irradiation was given ad 40 Gy (2 Gy/d/day 1-26). Radical surgery followed about day 56. Postoperatively patients received again 2 cycles of Taxol/5-FU and simultaneous irradiation with 30 Gy. Results: So far 30 patients were treated and all patients reached a CR after complete treatment, ongoing for 23/30 patients for 6 till 34 months: 4 patients developed a second neoplasia, and 3 patients gloved a local relapse. The principal toxicity was moderate (neutropenia, peripheral neuropathy, arthralgia/myalgia) and sensible with supportive care (e.g. PEG). Conclusions: The results suggest that the treatment of SCC of the head and neck with Taxol/5-FU and simultaneous radiation and radical surgery is a highly effective schedule and comparable with the treatment with Cisplatin/5-FU. (orig.) [Deutsch] Der Standard in der Behandlung weit forgeschrittener, primaer inoperabler Kopf-Hals-Tumoren stellte die Cisplatinhaltige Chemotherapiekombination mit 5-FU dar mit simultan

First Results from the AKARI FU-HYU Mission Program

Science.gov (United States)

Pearson, C.; Serjeant, S.; Takagi, T.; Jeong, W.-S.; Negrello, M.; Matsuhara, H.; Wada, T.; Oyabu, S.; Lee, H. M.; Im, M.

2009-12-01

The AKARI FU-HYU mission program has carried out mid-infrared imaging of several well studied Spitzer fields. This imaging fills in the wavelength coverage lacking from the Spitzer surveys and gives an extremely high scientific return for minimal input for AKARI. We select fields already rich in multi-wavelength data from radio to X-ray wavelengths and present the results from our initial analysis in the GOODS-N field. We utilize the comprehansive multiwavelength coverage in the GOODS-N field to produce a multiwavelength catalogue from infrared to ultraviolet wavelengths including photometric redshifts. Using the FU-HYU catalogue we present colour-colour diagrams that map the passage of PAH features through our observation bands. These colour-colours diagrams are used as tools to extract anomalous colour populations, in particular a population of Silicate Break galaxies from the GOODS-N field.

Design of 84 Ghz, 500 kW gyrotron for ECRH application

International Nuclear Information System (INIS)

Singh, Udaybir; Nitin Kumar; Anil Kumar; Rao, R.R.; Sinha, A.K.

2013-01-01

The design and numerical simulation of the 84 GHz gyrotron, are performed for first harmonic operation. TE 10,4 is selected as the operating mode after the rigorous analysis of several TE modes. Then the interaction cavity geometrical parameters are optimized on the basis of cold cavity simulations and Q factor calculation. The electron beam parameters are optimized in the beam-wave interaction simulations using Particle-in-Cell (PIC) code MAGIC. The triode-type magnetron injection gun with the accelerating voltage 70 kV, the beam current 10 A and the maximum transverse velocity spread less than 5% is designed. (author)

DC space-charge induced frequency up-shift in a quasi-optical gyrotron

International Nuclear Information System (INIS)

Alberti, S.; Tran, M.Q.; Tran, T.M.

1990-10-01

Recent experiments on a 100GHz quasi-optical gyrotron have shown that for a large resonator set-up the observed frequency up-shift between the starting current and a current of 10A corresponds to a shift of 4-5 longitudinal modes. In this Letter it is shown that the interpretation of this frequency up-shift should involve the current dependent electron beam voltage depression in the beam tunnel and the interaction region for both the single-mode and multi-mode time evolution codes. (author) 7 refs., 5 figs., 1 tab

Visuospatial attention and motor skills in kung fu athletes.

Science.gov (United States)

Muiños, Mónica; Ballesteros, Soledad

2013-01-01

The present study compared the performance of a group of sixteen kung fu athletes with that of a control group of fourteen nonathletes on a speeded visuospatial task and a hand-tapping motor task. In the visuospatial task the results showed that athletes were faster than the control participants when stimuli were presented at the periphery of the visual field at a middle and high presentation speed with short interstimulus intervals. Athletes were also significantly faster than nonathlete participants when performing motor actions such as hand-tapping with their dominant hand but groups did not differ with the nondominant hand. These results support the view that athletes perform some speeded visuospatial and motor tasks faster than nonathletes under certain conditions. The findings suggest that, after several years of practice, kung fu athletes develop certain skills that allow them to perform motor speed maneuvers under time pressure conditions.

Wavelet transform analysis of electromyography kung fu strikes data.

Science.gov (United States)

Neto, Osmar Pinto; Marzullo, Ana Carolina de Miranda

2009-11-01

In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG) analysis of such movements is non-trivial. This paper has three main goals: firstly, to investigate the differences in the EMG activity of muscles during strikes performed with and without impacts; secondly, to assess the advantages of using Sum of Significant Power (SSP) values instead of root mean square (rms) values when analyzing EMG data; and lastly to introduce a new method of calculating median frequency values using wavelet transforms (WMDF). EMG data of the deltoid anterior (DA), triceps brachii (TB) and brachioradialis (BR) muscles were collected from eight Kung Fu practitioners during strikes performed with and without impacts. SSP results indicated significant higher muscle activity (p = 0.023) for the strikes with impact. WMDF results, on the other hand, indicated significant lower values (p = 0. 007) for the strikes with impact. SSP results presented higher sensitivity than rms to quantify important signal differences and, at the same time, presented lower inter-subject coefficient of variations. The result of increase in SSP values and decrease in WMDF may suggest better synchronization of motor units for the strikes with impact performed by the experienced Kung Fu practitioners. Key PointsThe results show higher muscle activity and lower electromyography median frequencies for strikes with impact compared to strikes without.SSP results presented higher sensitivity and lower inter-subject coefficient of variations than rms results.Kung Fu palm strikes with impact may present better motor units' synchronization than strikes without.

Cell Line Derived 5-FU and Irinotecan Drug-Sensitivity Profiles Evaluated in Adjuvant Colon Cancer Trial Data

DEFF Research Database (Denmark)

Buhl, Ida Kappel; Gerster, Sarah; Delorenzi, Mauro

2016-01-01

patients who benefitted from the addition of irinotecan to 5-FU, we used gene expression profiles based on cell lines and clinical tumor material. These profiles were applied to expression data obtained from pretreatment formalin fixed paraffin embedded (FFPE) tumor tissue from 636 stage III colon cancer...... patients enrolled in the PETACC-3 prospective randomized clinical trial. A 5-FU profile developed similarly was assessed by comparing the PETACC-3 cohort with a cohort of 359 stage II colon cancer patients who underwent surgery but received no adjuvant therapy. RESULTS: There was no statistically...... to identify colon cancer patients who may benefit from 5-FU, however, any biomarker predicting benefit for adjuvant 5-FU must be rigorously evaluated in independent cohorts. Given differences between the two study cohorts, the present results should be further validated....

Pulsed RF Sources for Linear Colliders

International Nuclear Information System (INIS)

Fernow, R.C.

1995-01-01

These proceedings represent papers presented at the workshop on pulsed RF sources for linear colliders. The workshop examined the performance of RF sources for possible future linear colliders. Important sources were presented on new type of klystrons, gyrotrons and gyroklystrons. A number of auxiliary topics were covered, including modulators, pulse compression, power extraction, windows, electron guns and gun codes. The workshop was sponsored by the International Committee for Future Accelerators(ICFA), the U.S. Department of Energy and the Center for Accelerator Physics at Brookhaven National Laboratory. There were forty one papers presented at the workshop and all forty one have been abstracted for the Energy Science and Technology database

En procesorienteret miljøvurdering af F&U

DEFF Research Database (Denmark)

Lyhne, Ivar

Miljøperformance af fremtidens energiteknologier defineres i høj grad i de tidlige F&U aktiviteter. Energinet.dk har i flere år miljøvurderet ForskEL-programmet og i dette projekt forbedres systemets nytte ved at muliggøre øgede krav til programmets samlede performance og følge op på projekternes...

Gyrotron development at the Instituto de Pesquisas Espaciais

International Nuclear Information System (INIS)

Barroso, J.J.; Castro, P.J. de; Correa, R.A.; Galvao, G.P.

1987-01-01

The conceptual design of a 35GHz gyrotron operating in the TE 021 mode, intended for plasma heating experiments, is presented. The electrooptical system is synthesized from the electron beam parameters in the cavity region and the electrodynamical system includes a conventional resonator consisting of truncated cones. The starting and operating characteristics are calculated by integrating the exact equation of electron motion under the action of an RF fiel with fixed spatial distribution. For the moment, the experimental activities, in addition to providing all the infrastructure for the laboratory, are concentrated on the construction of a system of magnetic coils, able to generated a 15kG magnetic induction with a fluctuation of 0.1% over an extension of 13cm, on the manufacture of cavities by using electroforming techniques and on the development of techniques for the construction of electron guns. (author) [pt

Electrochemical degradation of 5-FU using a flow reactor with BDD electrode: Comparison of two electrochemical systems.

Science.gov (United States)

Ochoa-Chavez, A S; Pieczyńska, A; Fiszka Borzyszkowska, A; Espinoza-Montero, P J; Siedlecka, E M

2018-06-01

In this study, the electrochemical degradation process of 5-fluorouracil (5-FU) in aqueous media was performed using a continuous flow reactor in an undivided cell (system I), and in a divided cell with a cationic membrane (Nafion ® 424) (system II). In system I, 75% of 5-FU degradation was achieved (50 mg L -1 ) with a applied current density j app  = 150 A m -2 , volumetric flow rate qv = 13 L h -1 , after 6 h of electrolysis (k app  = 0.004 min -1 ). The removal efficiency of 5-FU was higher (95%) when the concentration was 5 mg L -1 under the same conditions. Nitrates (22% of initial amount of N), fluorides (27%) and ammonium (10%) were quantified after 6 h of electrolysis. System II, 77% of 5-FU degradation was achieved (50 mg L -1 ) after 6 h of electrolysis (k app  = 0.004 min -1 ). The degradation rate of 5-FU was complete when the concentration was 5 mg L -1 under the same conditions. Nitrates (29% of initial amount of N), fluorides (25%) and ammonium (5%) were quantified after 6 h of electrolysis. In addition, the main organic byproducts identified by mass spectroscopy were aliphatic compound with carbonyl and carboxyl functionalities. Due to, the mineralization of 5-FU with acceptable efficiency of 88% found in system II (j app of 200 A m -2 ), this system seems to be more promising in the cytostatic drug removal. Moreover the efficiency of 5-FU removal in diluted solutions is better in system II than in system I. Copyright © 2018 Elsevier Ltd. All rights reserved.

On the errors in measurements of Ohio 5 radio sources in the light of the GB survey

International Nuclear Information System (INIS)

Machalski, J.

1975-01-01

Positions and flux densities of 405 OSU 5 radio sources surveyed at 1415 MHz down to 0.18 f.u. (Brundage et al. 1971) have been examined in the light of data from the GB survey made at 1400 MHz (Maslowski 1972). An identification analysis has shown that about 56% of OSU sources reveal themselves as single, 18% - as confused, 20% - as unresolved and 6% - having no counterparts in the GB survey down to 0.09 f.u. - seem to be spurious. The single OSU sources are strongly affected by the underestimation of their flux densities due to base-line procedure in their vicinity. The average value of about 0.03 f.u. has been found for the systematic underestimation. The second systematic error is due to the presence of a significant number of confused sources with strong overestimation of their flux densities. The confusion effect gives a characteristic non-Gaussian tail in the difference distribution between observed and real flux densities. The confusion effect has a strong influence on source counts from the OSU 5 survey. Differential number-counts relatively to that from the GB survey shows that the counts agree between themselves within the statistical uncertainty up to about 0.40 f.u., which is approximately 4 delta (delta - average rms flux density error in the OSU 5 survey). Below 0.40 f.u. the number of sources missing due to the confusion effect is significantly greater than the number-overestimation due to the noise error. Thus, this part of the OSU 5 source counts cannot be treated seriously, even in the statistical sense. An analysis of the approximate reliability and completeness of the OSU 5 survey shows that, although the total reliability estimated by the authors of the survey is good, the completeness is significantly lower due to the underestimation of the confusion effect magnitude. In fact, the OSU 5 completeness is 67% at 0.18 f.u. and 79% at 0.25 f.u. (author)

NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.

Science.gov (United States)

Narayan, Satya; Jaiswal, Aruna S; Sharma, Ritika; Nawab, Akbar; Duckworth, Lizette Vila; Law, Brian K; Zajac-Kaye, Maria; George, Thomas J; Sharma, Jay; Sharma, Arun K; Hromas, Robert A

2017-08-22

The 5-fluorouracil (5-FU) treatment induces DNA damage and stalling of DNA replication forks. These stalled replication forks then collapse to form one sided double-strand breaks, leading to apoptosis. However, colorectal cancer (CRC) stem cells rapidly repair the stalled/collapsed replication forks and overcome treatment effects. Recent evidence suggests a critical role of checkpoint kinase 1 (Chk1) in preventing the replicative stress. Therefore, Chk1 kinase has been a target for developing mono or combination therapeutic agents. In the present study, we have identified a novel orphan molecule NSC30049 (NSC49L) that is effective alone, and in combination potentiates 5-FU-mediated growth inhibition of CRC heterogeneous bulk and FOLFOX-resistant cell lines in culture with minimal effect on normal colonic epithelial cells. It also inhibits the sphere forming activity of CRC stem cells, and decreases the expression levels of mRNAs of CRC stem cell marker genes. Results showed that NSC49L induces 5-FU-mediated S-phase cell cycle arrest due to increased load of DNA damage and increased γ-H2AX staining as a mechanism of cytotoxicity. The pharmacokinetic analysis showed a higher bioavailability of this compound, however, with a short plasma half-life. The drug is highly tolerated by animals with no pathological aberrations. Furthermore, NSC49L showed very potent activity in a HDTX model of CRC stem cell tumors either alone or in combination with 5-FU. Thus, NSC49L as a single agent or combined with 5-FU can be developed as a therapeutic agent by targeting the Chk1 pathway in 5-FU-resistant CRC heterogeneous bulk and CRC stem cell populations.

Multimegawatt relativistic harmonic gyrotron traveling-wave tube amplifier experiments

International Nuclear Information System (INIS)

Menninger, W.L.; Danly, B.G.; Temkin, R.J.

1996-01-01

The first multimegawatt harmonic relativistic gyrotron traveling-wave tube (gyro-twt) amplifier experiment has been designed, built, and tested. Results from this experimental setup, including the first ever reported third-harmonic gyro-twt results, are presented. Operation frequency is 17.1 GHz. Detailed phase measurements are also presented. The electron beam source is SNOMAD-II, a solid-state nonlinear magnetic accelerator driver with nominal parameters of 400 kV and 350 A. The flat-top pulsewidth is 30 ns. The electron beam is focused using a Pierce geometry and then imparted with transverse momentum using a bifilar helical wiggler magnet. Experimental operation involving both a second-harmonic interaction with the TE 21 mode and a third-harmonic interaction with the TE 31 mode, both at 17 GHz, has been characterized. The third-harmonic interaction resulted in 4-MW output power and 50-dB single-pass gain, with an efficiency of up to ∼8%. The best measured phase stability of the TE 31 amplified pulse was ±10 degree over a 9-ns period. The phase stability was limited because the maximum RF power was attained when operating far from wiggler resonance. The second harmonic, TE 21 had a peak amplified power of 2 MW corresponding to 40-dB single-pass gain and 4% efficiency. The second-harmonic interaction showed stronger superradiant emission than the third-harmonic interaction. Characterizations of the second- and third-harmonic gyro-twt experiments presented here include measurement of far-field radiation patterns, gain and phase versus interaction length, phase stability, and output power versus input power

Development program for a 200-kW, cw gyrotron. Quarterly report No. 9, July-September 1981

International Nuclear Information System (INIS)

Tancredi, J.J.; Caplan, M.; Matranga, V.A.; Sandoval, J.J.

1981-01-01

The objective of this program is the design and development of a millimeter-wave device to produce 200 kW of continuous-wave power at 60 GHz. The device, which will be a gyrotron oscillator, will be compatible with power delivery to an electron-cyclotron plasma. Smooth control of rf power output over a 17 dB range is required, and the device should be capable of operation into a severe time-varying rf load mismatch. The superconducting solenoid which had been sent back to the manufacturer because of an open coil, was repaired and returned to Hughes. The gyrotron S/N 1 was successfully operated at a frequency of 59.7 GHz with a power level of 160 kW peak. Diagnostic x-ray measurements of the collector area revealed a reasonable beam power density of 600 W/cm 2 , under worst case conditions of no rf output, and with no auxilary means of spreading the beam. The latter portion of this report period was spent characterizing S/N 1's rf and dc performance and evaluating an anomolous oscillation emitted from the electron gun

The cardiovascular responses of male subjects to kung fu techniques. Expert/novice paradigm.

Science.gov (United States)

Jones, M A; Unnithan, V B

1998-12-01

The primary aim was to assess cardiovascular responses of expert and novice subjects to kung fu techniques. It was hypothesised that experienced subjects would demonstrate improved economy of movement during the techniques, evidenced by reduced exercise intensity. a comparative design was established utilising two groups; experienced (group E), and novice (group N). the experimentation took place under laboratory conditions, but was designed to maximise external validity. the only preselection variables were regular attendance at training and experience. Nine experienced males (group E, exp 9.5 +/- 5.2 yrs) and nine novice males (group N, exp 1.2 +/- 0.1 yrs) participated. The only exclusion guidelines were contraindications to participate within a maximal test, no subjects were excluded upon this basis. N/A. each subject participated in three kung fu protocols (forms, kicking and punching). Each protocol, randomly allocated, consisted of ten work (30 sec) and ten rest periods (30 sec). MEASURES taken during the protocols were heart rate (HR) and oxygen consumption (VO2). These were expressed as a percentage of maximal values to reflect exercise intensity. During both the form protocol and punching protocol group E were found to be working at a significantly (p kung fu techniques differ depending upon experience level. It is difficult to directly relate this to improved economy since work output could not be accurately quantified. It was also found that kung fu protocols elicited exercise intensity into the cardiovascular training zone.

Characteristics of a superconducting magnet using a persistent current for a 110 GHz gyrotron

International Nuclear Information System (INIS)

Maebara, Sunao; Kasugai, Atsushi; Sakamoto, Keishi; Tsuneoka, Masaki; Imai, Tsuyoshi

1996-03-01

A superconducting magnet (SCM) using a persistent current for a 110 GHz gyrotron was developed to reduce liquid-helium loss, the boiled-off rate of 0.13 liter/hour was attained in a persistent current operation. It shows that the continuous operation for 50 days is capable without additional liquid-helium supply. Moreover, the 3040 liter in a year is used for a gyrotron test during five months and for the maintenance during seven months and liquid-helium savings of 65% was successfully demonstrated. The SCM is capable to excite the maximum magnetic field of 5.0 T in the persistent current mode. A mirror ratio between resonant cavity and magnetron injection gun (MIG) is 20 for operating the main coils in the persistent mode, since cavity coils and gun coils are connected in series. Auxiliary coils are equipped independently to control the mirror ratio, the mirror ratio of 13.6 - 37.0 at the 110 GHz is available. A two-stage refrigerator using helium gas was also installed and made liquid-nitrogen for cooling thermal shield of 80 K free. By developing this new type SCM, the number of routine works was drastically decreased in one time per 22-50 days, while routine works of a few times per week was needed up to now. (author)

Analysis of parasitic oscillations in 42 GHz gyrotron beam tunnel

Science.gov (United States)

Kumar, N.; Singh, U.; Singh, T. P.; Sinha, A. K.

2011-02-01

Parasitic oscillation excitation analysis has been carried out for the 42 GHz gyrotron beam tunnel. This article presents a systematic approach for the analysis of parasitic oscillation excitation. The electron trajectory code EGUN has been used for the estimation of the electron beam parameters in the beam tunnel. The electromagnetic simulation code CST-MS has been used for the eigenmode and Q value analysis. The analysis of the parasitic oscillations has been performed for the symmetric TE modes and the first three cavity side copper rings. Four different approaches- the Q value study, the mode maxima-electron beam radius mismatching, the electron cyclotron frequency-mode excitation frequency mismatching and the backward wave interaction analysis- have been used for the parasitic oscillation analysis.

[Mining analysis on composition and medication of menstruation prescriptions in Fu Qingzhu's Obstetrics and Gynecology].

Science.gov (United States)

Zhu, Jia-qing; Che, Yu-xia

2015-04-01

In this paper, menstruation prescriptions were selected from "Fu Qingzhu's Obstetrics and Gynecology" and analyzed by using GRI algorithm, correlation analysis, hierarchical clustering method through SPSS, Clementine and traditional Chinese medicine (TCM) inheritance auxiliary systems, in order to screen out 15 menopathy prescriptions, which involve 45 traditional Chinese medicine herbs. In the study, blood-tonifying and qi-tonifying herbs were found to be frequent in the prescriptions. The most frequent single herb was white paeony root, accounting for 9.6% in the total number of prescriptions; The most frequent herb pairs were white paeony root-radix rehmanniae preparata and paeony root-angelica sinensis. Among Fu Shan's menopathy prescriptions, 61 herbal pairs showed a correlation coefficient exceeding 0.05, which evolved into 16 pairs of core combinations. The analysis showed that menopathy prescriptions in volume 1 of "Fu Qingzhu's Obstetrics and Gynecology" focused on tonic traditional Chinese medicines involving liver, spleen and kidney and were adjusted according to changes in qi, blood, cold, hot and wet, which could provide a specific reference for further studies on Fu Shan's academic thoughts and traditional Chinese medicine clinical treatment of menopathy.

The FU Orionis outburst as a thermal accretion event: Observational constraints for protostellar disk models

Science.gov (United States)

Bell, K. R.; Lin, D. N. C.; Hartmann, L. W.; Kenyon, S. J.

1995-01-01

The results of the time-dependent disk models developed in Bell & Lin are compared with observed properties of FU Orionis variables. Specific models are fit to the light curves of Fu Ori, V1515 Cyg, and V1057 Cyg. The slow risetime of V1515 Cyg can be matched by a self-regulated outburst model. The rapid risetimes of FU Ori and V1057 Cyg can be fitted with the application of modest perturbations to the disk surface density. Model disks display spectral features characteristic of observed objects. The color evolution of V1057 Cyg is naturally explained if mass flux drops in the inner disk (r less than 1/4 AU) while remaining steady in the outer disk. The decrease in optical line width (rotational velocity) observed during the decay of V1057 Cyg may be accounted for by an outward-propagating ionization front. We predict that before final decay to the quiescent phase, short-wavelength line widths (lambda less than 1.5 microns) will again increase. It is suggested that FU Orionis outbursts primarily occur to systems during the embedded phase with ages less than several times 10(exp 5) yr.

The upgrade of the DIII-D EC system using 120 GHz ITER gyrotrons

International Nuclear Information System (INIS)

Callis, R.W.; Lohr, J.; Gorelov, I.A.; Ponce, D.; Kajiwara, K.; Tooker, J.F.

2005-01-01

The planned growth in the EC system on DIII-D over the next few years requires the installation of two depressed collector gyrotrons, a high voltage power supply, two low loss transmission lines, and the required support equipment. This new DIII-D EC equipment could be made identical to the ITER EC system requirements. By building the DIII-D hardware to the ITER specifications, it will allow ITER to gain beneficial prototyping experience on a working tokamak, prior to committing to building the hardware for delivery to ITER

EVIDENCE FOR AN FU ORIONIS-LIKE OUTBURST FROM A CLASSICAL T TAURI STAR

International Nuclear Information System (INIS)

Miller, Adam A.; Poznanski, Dovi; Silverman, Jeffrey M.; Kleiser, Io K. W.; Cenko, S. Bradley; Bloom, Joshua S.; Filippenko, Alexei V.; Hillenbrand, Lynne A.; Kasliwal, Mansi M.; Ofek, Eran O.; Quimby, Robert M.; Covey, Kevin R.; Rojas-Ayala, Barbara; Muirhead, Philip S.; Law, Nicholas M.; Dekany, Richard G.; Rahmer, Gustavo; Hale, David; Smith, Roger; Nugent, Peter

2011-01-01

We present pre- and post-outburst observations of the new FU Orionis-like young stellar object PTF 10qpf (also known as LkHα 188-G4 and HBC 722). Prior to this outburst, LkHα 188-G4 was classified as a classical T Tauri star (CTTS) on the basis of its optical emission-line spectrum superposed on a K8-type photosphere and its photometric variability. The mid-infrared spectral index of LkHα 188-G4 indicates a Class II-type object. LkHα 188-G4 exhibited a steady rise by ∼1 mag over ∼11 months starting in August 2009, before a subsequent more abrupt rise of >3 mag on a timescale of ∼2 months. Observations taken during the eruption exhibit the defining characteristics of FU Orionis variables: (1) an increase in brightness by ∼>4 mag, (2) a bright optical/near-infrared reflection nebula appeared, (3) optical spectra are consistent with a G supergiant and dominated by absorption lines, the only exception being Hα which is characterized by a P Cygni profile, (4) near-infrared spectra resemble those of late K-M giants/supergiants with enhanced absorption seen in the molecular bands of CO and H 2 O, and (5) outflow signatures in H and He are seen in the form of blueshifted absorption profiles. LkHα 188-G4 is the first member of the FU Orionis-like class with a well-sampled optical to mid-infrared spectral energy distribution in the pre-outburst phase. The association of the PTF 10qpf outburst with the previously identified CTTS LkHα 188-G4 (HBC 722) provides strong evidence that FU Orionis-like eruptions represent periods of enhanced disk accretion and outflow, likely triggered by instabilities in the disk. The early identification of PTF 10qpf as an FU Orionis-like variable will enable detailed photometric and spectroscopic observations during its post-outburst evolution for comparison with other known outbursting objects.

Evolutionism through Chinese Eyes: Yan Fu, Ma Junwu and Their translations of Darwinian Evolutionism

Directory of Open Access Journals (Sweden)

Tsing-song Vincent Shen

2015-04-01

Full Text Available The huge impact that Darwinian Evolutionism has effected over Chinese intellectuals through Yan Fu's translation of Huxley's "Evolution and Ethics" into the Tianyanlun, is in fact based on Chinese traditional worldview on the one hand and the novel ideas it brings to the Chinese mind facing the challenge of transition. However, Yan Fu's translation is not as scientific as it should be when dealing with Huxley's discourse. Ma Junwu's translation of Darwin's "On the Origin of Species" attempts to be more scientific, in an effort to supply exact scientific terms and discourse in Chinese. However, at the end it is social Darwinism that has won the mind of the Chinese people. This paper analyses the ideas in Chinese past that leads to Chinese perception of Darwimism evolutionism and examines the ways it has been translated by Yan Fu and Ma Junwu.  

High response rates following paclitaxel/5-FU and simultaneous radiotherapy in advanced head and neck carcinoma

International Nuclear Information System (INIS)

Schroeder, M.; Westerhausen, M.; Makoski, H.B.; Sesterhenn, K.; Schroeder, R.

1997-01-01

The main stay of treatment for head and neck cancer patients with advanced disease has been chemotherapy with Cisplatin/5-FU and simultaneous applied radiotherapy. With this multimodality treatment including radical surgery after two cycles of neoadjuvant chemotherapy and 40 Gy radiotherapy we reported 60% complete remission after 5 years for patients with stage III/IV of head and neck cancer. Paclitaxel, a new plant product, has demonstrated significant antineoplastic activity in head and neck tumors (ECOG-Study: 40% RR). Therefore we performed a trial with Taxol/5-FU and simultaneous radiation in a neoadjuvant and postoperative adjuvant setting of stage III/IV squamous cell carcinoma of the head and neck with pre-existent contraindication against Cisplatin. Patients and Methods: 30 patients with a primarily inoperable stage III/IV of SCC of the head and neck were enrolled to receive day 1 and 29 Taxol 175 mg/m 2 as a 3-hour-infusion, followed by 120-hour-cvi of 1000 mg/m 2 /d 5-FU. Locally irradiation was given ad 40 Gy (2 Gy/d/day 1-26). Radical surgery followed about day 56. Postoperatively patients received again 2 cycles of Taxol/5-FU and simultaneous irradiation with 30 Gy. Results: So far 30 patients were treated and all patients reached a CR after complete treatment, ongoing for 23/30 patients for 6 till 34 months: 4 patients developed a second neoplasia, and 3 patients gloved a local relapse. The principal toxicity was moderate (neutropenia, peripheral neuropathy, arthralgia/myalgia) and sensible with supportive care (e.g. PEG). Conclusions: The results suggest that the treatment of SCC of the head and neck with Taxol/5-FU and simultaneous radiation and radical surgery is a highly effective schedule and comparable with the treatment with Cisplatin/5-FU. (orig.) [de

Post-operative chemosensitized radiation with modulated 5-fluorouracil (5-FU) following resection of adenocarcinoma of the esophagus and esophagogastric (EG) junction

International Nuclear Information System (INIS)

Kurtzman, S.M.; Whittington, R.; Vaughn, D.; Rosato, E.F.; Haller, D.G.

1995-01-01

Purpose: To evaluate the survival and toxicity of post-operative chemosensitized radiation with modulated 5-FU chemotherapy in patients with resected adenocarcinomas of the esophagus and EG junction. Materials and Methods: One hundred and ninety-two patients with localized adenocarcinomas of the esophagus and EG junction were treated with single or combined modality therapy. The results in the first 165 patients treated between 1972 and 1989 demonstrated that survival was improved with chemosensitized radiation therapy following surgical resection. In the final group of patients treated between 1985 and 1989 a 96 hour inpatient 5-FU infusion was used to provide chemosensitization in those patients. Twenty-seven patients have been treated between January 1990 and December 1994 using a new outpatient regimen with modulated 5-FU chemotherapy for chemosensitization. Radiation and chemotherapy commenced within 6 weeks of surgery. The dose of radiation was 54 Gy in patients with no residual tumor, and 59.4 to 63.0 Gy in patients with positive margins or residual tumor. Modulated 5-FU using bolus 5-FU with Leukovorin +/-α-interferon (α-IFN) was given during the first and fifth week of radiation. Results: Median follow-up of surviving patients treated with modulated 5-FU is 15 months (max - 46 mos). Survival is 71% at 1 year, 45% at 2 years and 39% at 3 years. This compares favorably with the survival with 5-FU infusion, 75% - 1 year, 35% - 2 year, and 10% - 3 year. The toxicity of modulated 5-FU was no different from that observed in patients treated with 5-FU infusion. Three patients treated with modulated 5-FU leukovorin and α-IFN required intravenous hydration, and two patients experienced grade 3 leukopenia. There were two radiation related events in these patients, one case of radiation pneumonitis and one patient with pericarditis. Conclusions: Based on this experience, aggressive therapy of adenocarcinomas of the esophagus and EG junction with surgery and

Evaluation of 5-FU pharmacokinetics in cancer patients with DPD deficiency using a Bayesian limited sampling strategy

NARCIS (Netherlands)

Van Kuilenburg, A.; Hausler, P.; Schalhorn, A.; Tanck, M.; Proost, J.H.; Terborg, C.; Behnke, D.; Schwabe, W.; Jabschinsky, K.; Maring, J.G.

Aims: Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme in the catabolism of 5-fluorouracil (5FU) and DPD deficiency is an important pharmacogenetic syndrome. The main purpose of this study was to develop a limited sampling strategy to evaluate the pharmacokinetics of 5FU and to detect

Synthesis, characterization and in vitro evaluation of magnetic nanoparticles modified with PCL-PEG-PCL for controlled delivery of 5FU.

Science.gov (United States)

Asadi, Nahideh; Annabi, Nasim; Mostafavi, Ebrahim; Anzabi, Maryam; Khalilov, Rovshan; Saghfi, Siamak; Mehrizadeh, Masoud; Akbarzadeh, Abolfazl

2018-02-22

Magnetic nanoparticles have properties that cause to apply them in cancer therapy and vehicles for the delivery of drugs such as 5FU, especially when they are modified with biocompatible copolymers. The aim of this study is to modify superparamagnetic iron oxide nanoparticles (SPIONPs) with PCL-PEG-PCL copolymers and then utilization of these nanoparticles for encapsulation of anticancer drug 5FU. The ring-opening polymerization (ROP) was used for the synthesis of PCL-PEG-PCL copolymer by ε-caprolactone (PCL) and polyethylene glycol (PEG2000). We used the double emulsion method (water/oil/water) to prepare 5FU-encapsulated Fe 3 O 4 magnetic nanoparticles modified with PCL-PEG-PCL copolymer. Chemical structure and magnetic properties of 5FU-loaded magnetic-polymer nanoparticles were investigated systematically by employing FT-IR, XRD, VSM and SEM techniques. In vitro release profile of 5FU-loaded NPs was also determined. The results showed that the encapsulation efficiency value for nanoparticles were 90%. Moreover, the release of 5FU is significantly higher at pH 5.8 compared to pH 7.4. Therefore, these nanoparticles have sustained release and can apply for cancer therapy.

CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer

Directory of Open Access Journals (Sweden)

Yang K

2016-11-01

Full Text Available Kai Yang, Kai Gao, Gui Hu, Yanguang Wen, Changwei Lin, Xiaorong Li Department of General Surgery, The Third Affiliated Hospital of Central South University, Central South University, Changsha, Hunan, People’s Republic of China Abstract: Colorectal cancer (CRC is one of the most commonly diagnosed cancers among both males and females; the chemotherapy drug 5-fluorouracil (5-FU is one of a doctors’ first lines of defense against CRC. However, therapeutic failures are common because of the emergence of drug resistance. Connective tissue growth factor (CTGF is a secreted protein that binds to integrins, and regulates the invasiveness and metastasis of certain carcinoma cells. Here, we found that CTGF was upregulated in drug-resistant phenotype of human CRC cells. Overexpression of CTGF enhanced the resistance to 5-FU-induced cell apoptosis. Moreover, downregulating the expression of CTGF promoted the curative effect of chemotherapy and blocked the cell cycle in the G1 phase. We also found that CTGF facilitated resistance to 5-FU-induced apoptosis by increasing the expression of B-cell lymphoma-extra large (Bcl-xL and survivin. Then we pharmacologically blocked MEK/ERK signal pathway and assessed 5-FU response by MTT assays. Our current results indicate that the expression of phosphorylated forms of MEK/ERK increased in high CTGF expression cells and MEK inhibited increases in 5-FU-mediated apoptosis of resistant CRC cells. Therefore, our data suggest that MEK/ERK signaling contributes to 5-FU resistance through upstream of CTGF, and supports CRC cell growth. Comprehending the molecular mechanism underlying 5-FU resistance may ultimately aid the fight against CRC. Keywords: connective tissue growth factor, 5-fluorouracil, mitogen-activated protein kinase/extracellular regulated protein kinases, phosphatidyl inositol 3-kinase/serine/threonine kinase Akt, colorectal cancer

Potentially functional SNPs (pfSNPs as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.

Directory of Open Access Journals (Sweden)

Jingbo Wang

Full Text Available 5-Fluorouracil (5-FU and its pro-drug Capecitabine have been widely used in treating colorectal cancer. However, not all patients will respond to the drug, hence there is a need to develop reliable early predictive biomarkers for 5-FU response. Here, we report a novel potentially functional Single Nucleotide Polymorphism (pfSNP approach to identify SNPs that may serve as predictive biomarkers of response to 5-FU in Chinese metastatic colorectal cancer (CRC patients. 1547 pfSNPs and one variable number tandem repeat (VNTR in 139 genes in 5-FU drug (both PK and PD pathway and colorectal cancer disease pathways were examined in 2 groups of CRC patients. Shrinkage of liver metastasis measured by RECIST criteria was used as the clinical end point. Four non-responder-specific pfSNPs were found to account for 37.5% of all non-responders (P<0.0003. Five additional pfSNPs were identified from a multivariate model (AUC under ROC = 0.875 that was applied for all other pfSNPs, excluding the non-responder-specific pfSNPs. These pfSNPs, which can differentiate the other non-responders from responders, mainly reside in tumor suppressor genes or genes implicated in colorectal cancer risk. Hence, a total of 9 novel SNPs with potential functional significance may be able to distinguish non-responders from responders to 5-FU. These pfSNPs may be useful biomarkers for predicting response to 5-FU.

Analysis of Mig-type electron guns for a 35GHz gyrotron

International Nuclear Information System (INIS)

Barroso, J.J.; Galvao, G.P.

1988-05-01

A 35GHz gyrotron is currently under construction at the Associated Plasma Laboratory of the Institute for Space Research to be used in plasma heating and noninductive current drive experiments. A critical component of the device is the electrooptical system, which must generate a beam with low velocity spread and high transverse energy. One way to decrease the velocity spread is to use laminar beams. For laminar flow, where the trajectories do not cross, the axial component of the space-charge forces changes sign each half cycle models of magnetron injection guns that produce laminar beams are analyzed and procedures for controlling the pitch angle parameter, which defines the transverse-to-axial electron velocity ratio are investigated. (author)

Chemoresistance to 5-FU inhibited by 635 nm LED irradiation in CD133+ KB cell line.

Science.gov (United States)

Kim, Donghwi; Park, Mineon; Jang, Hyunwoong; Hyun, Hoon; Lim, Wonbong

2018-01-01

Consistent with cancer stem cell theory, a small fraction of cancer cells, described as cancer stem cells (CSCs), may promote tumor recurrence and anti-cancer drug resistance. Therefore, much effort has been devoted to the development of CSC targeted therapy to vanquish drug resistance. In this study, we have investigated the effect of multiple light-emitting diode (LED) irradiation treatments with conventional anti-cancer drugs on CSC-like oral cancer cells that acquired stemness by ectopic over expression of CD133. To evaluate combined LED irradiation anti-cancer drug effects, we investigated the chemosensitizing effect of 635 nm irradiation on 5-fluorouracil (5FU)-treated KB CD133+ and KB Vec cells, interrogating the underlying molecular mechanisms associated with stemness and apoptosis that are responsible for chemopreventive activity. In addition, combination therapy with LED irradiation and 5-FU treatment was carried out in KB CD133+ and KB Vec cell-inoculated mouse models. LED irradiation of 635 nm inhibited CSC-like properties consistent with a decrease in OCT4 and NANOG protein expression, reducing colony-forming ability. In addition, LED irradiation enhanced 5-FU-induced cytotoxicity and improved 5-FU chemosensitivity in KB CD133+ via enhancement of apoptosis. These findings were validated in vivo, wherein LED irradiation combined with 5-FU treatment inhibited tumor growth in KB CD133+ -inoculated mice. Collectively, our results provide novel evidence for 635 nm irradiation-induced 5-FU chemosensitization of CSC in oral cancer. In addition, this research highlights that 635 nm LED irradiation may serve as an adjunct treatment to conventional chemotherapeutic drugs in patients with oral cancer.

Force, reaction time, and precision of Kung Fu strikes.

Science.gov (United States)

Neto, Osmar Pinto; Bolander, Richard; Pacheco, Marcos Tadeu Tavares; Bir, Cynthia

2009-08-01

The goal was to compare values of force, precision, and reaction time of several martial arts punches and palm strikes performed by advanced and intermediate Kung Fu practitioners, both men and women. 13 Kung Fu practitioners, 10 men and three women, participated. Only the men, three advanced and seven intermediate, were considered for comparisons between levels. Reaction time values were obtained using two high speed cameras that recorded each strike at 2500 Hz. Force of impact was measured by a load cell. For comparisons of groups, force data were normalized by participant's body mass and height. Precision of the strikes was determined by a high speed pressure sensor. The results show that palm strikes were stronger than punches. Women in the study presented, on average, lower values of reaction time and force but higher values of precision than men. Advanced participants presented higher forces than intermediate participants. Significant negative correlations between the values of force and precision and the values of force and reaction time were also found.

Magnetron injection gun for a broadband gyrotron backward-wave oscillator

International Nuclear Information System (INIS)

Yuan, C. P.; Chang, T. H.; Chen, N. C.; Yeh, Y. S.

2009-01-01

The magnetron injection gun is capable of generating relativistic electron beam with high velocity ratio and low velocity spread for a gyrotron backward-wave oscillator (gyro-BWO). However, the velocity ratio (α) varies drastically against both the magnetic field and the beam voltage, which significantly limits the tuning bandwidth of a gyro-BWO. This study remedies this drawback by adding a variable trim field to adjust the magnetic compression ratio when changing the operating conditions. Theoretical results obtained by employing a two-dimensional electron gun code (EGUN) demonstrate a constant velocity ratio of 1.5 with a low axial velocity spread of 6% from 3.4-4.8 Tesla. These results are compared with a three-dimensional particle-tracing code (computer simulation technology, CST). The underlying physics for constant α will be discussed in depth.

Magnetron injection gun for a broadband gyrotron backward-wave oscillator

Science.gov (United States)

Yuan, C. P.; Chang, T. H.; Chen, N. C.; Yeh, Y. S.

2009-07-01

The magnetron injection gun is capable of generating relativistic electron beam with high velocity ratio and low velocity spread for a gyrotron backward-wave oscillator (gyro-BWO). However, the velocity ratio (α) varies drastically against both the magnetic field and the beam voltage, which significantly limits the tuning bandwidth of a gyro-BWO. This study remedies this drawback by adding a variable trim field to adjust the magnetic compression ratio when changing the operating conditions. Theoretical results obtained by employing a two-dimensional electron gun code (EGUN) demonstrate a constant velocity ratio of 1.5 with a low axial velocity spread of 6% from 3.4-4.8 Tesla. These results are compared with a three-dimensional particle-tracing code (computer simulation technology, CST). The underlying physics for constant α will be discussed in depth.

[Study of the immunological mechanism of anti-tumor effects of 5-FU by establishing EL4 tumor-bearing mouse models].

Science.gov (United States)

Li, Mo-Lin; Li, Chuan-Gang; Shu, Xiao-Hong; Li, Ming-Xia; Jia, Yu-Jie; Qin, Zhi-Hai

2007-11-01

To investigate the immunological mechanism of anti-tumor effect of 5-FU by establishing lymphoma EL4 tumor-bearing mouse models in wild type C57BL/6 mice and nude C57BL/6 mice, respectively. The mouse lymphoma EL4 cells were inoculated subcutaneously into wild type C57BL/6 mice (immune-competent mice). Twelve days later, 5-FU of different doses was administered intraperitoneally to treat these wild type C57BL/6 tumor-bearing mice. The size of tumors in the wild type C57BL/6 mice was observed and recorded to explore the minimal dose of 5-FU that could cure the tumor-bearing mice. Then the same amount of EL4 tumor cells was inoculated subcutaneously into wild type C57BL/6 mice and nude C57BL/6 mice (T cell-deficient mice) simultaneously, which had the same genetic background of C57BL/6. Twelve days later, 5-FU of the minimal dose was given intraperitoneally to treat both the wild type and nude C57BL/6 tumor-bearing mice. The size of tumors in the two different types of mice was observed and recorded. A single dose of 5-FU (75 mg/kg) cured both the EL4 tumor-bearing wild type C57BL/6 mice and the EL4 tumor-bearing nude C57BL/6 mice in the first week. Two weeks after 5-FU treatment, all of the nude mice died of tumor relapse while most of the wild type C57BL/6 mice were fully recovered. A single dose of 5-FU has marked anti-tumor effects on lymphoma EL4 tumor-bearing C57BL/6 mice with or without T lymphocytes. The relapse of tumors after 5-FU treatment might be related to the function of T lymphocytes.

Generation of electron beams in cyclotron motion and its interaction with electromagnetic fields in weakly irregular cavities: a study applied to conceptual elaboration of a 35 GHz gyrotron

International Nuclear Information System (INIS)

Castro, J.J.B. de.

1988-12-01

It is presented an investigation of different phenomena that occur in the gyrotron: 1) generation and transport of helical electron beams, 2) interaction of electrons in cyclotron motion with a transverse electric mode in resonant cavities operating near cutoff and 3) electron deposition over the collector active region. An exact ballistic model, which points out the nonlinear attributes of the relativistic equation of electron cyclotron motion and that includes a complex formulation for the longitudinal electric field distribution in weakly irregular waveguides, is used. Physically realizable RF field profiles are studied with the objective of maximizing gyrotron efficiency. For this purpose, an investigation is made of the resonant properties of truncated cones cavities and a new resonator type, with a profile described in terms of a continuous function, is developed. High perpendicular efficiencies (η perpendicular MAX =0.86) have been calculated for interaction at the fundamental 1 cyclotron harmonic and for uniform external magnetic field. A maximum efficiency scaling parameter S has been introduced, by which scaling relations η perpendicular MAX = η perpendicular MAX (S) are applicable to a variety of field profiles. The conceptual design of a 35 GHz gyrotron gives emphasis to selection criteria of operating parameters in compliance with technical constraints and with the requirement of soft self-excited oscillations. The proposed gyrotron operates in the azimuthally symetrical mode TE 021 and is able to produce, with an electronic efficiency of 40%, an output power of 100 kW, in pulses of 20 ms, with a duty factor of 0.04%. (author) [pt

Relationship between pharmacokinetics of 5-FU in plasma and in saliva, and toxicity of 5-fluorouracil/folinic acid

NARCIS (Netherlands)

Jansman, FGA; Coenen, JLLM; De Graaf, JC; Tobi, H; Sleijfer, DT; Brouwers, JRBJ

2002-01-01

Background: Dose adaptation based on pharmacokinetic parameters has been shown to decrease toxicity of some 5-fluorouracil(5-FU)-based continuous infusion regimens. Patients and Methods: In the present study the relationship between 5-FU pharmacokinetics in plasma and in saliva, and toxicity was

Entwicklung einer Methode zur monetären Bewertung des Wassers für ein Unternehmen unter Einbeziehung des Wasser-Fußabdrucks

OpenAIRE

Hentschel, Nora

2011-01-01

Wassernutzung und Abbau der Frischwasser-Ressourcen sind heutzutage ein Thema, das als so wichtig wahrgenommen wird wie der Klimawandel. Wasser wird somit zunehmend Auswirkungen auf den ökonomischen Wert von Unternehmen haben. Ziel der vorliegenden Arbeit ist es, den monetären Wert des Wassers mithilfe des Wasser-Fußabdrucks zu bestimmen. Hierfür werden nach einer kurzen Einführung in Kapitel 2 der ökologische Fußabdruck, der CO2-Fußabdruck und der Wasser-Fußabdruck kurz vorgestellt und in...

Herbal medicine Guan Chang Fu Fang enhances 5-fluorouracil cytotoxicity and affects drug-associated genes in human colorectal carcinoma cells.

Science.gov (United States)

Yu, Chen; Liu, Shen-Lin; Qi, Ming-Hao; Zou, Xi; Wu, Jian; Zhang, Jing

2015-02-01

Guan Chang Fu Fang (GCFF) is a natural compound, which is extracted from three medicinal plants, Agrimonia pilosa Ledeb ., Patrinia scabiosaefolia and Solanum nigrum L . GCFF has demonstrated clinical efficacy in the treatment of colon cancer. At present, 5-fluorouracil (5-FU) is the primary active chemotherapeutic agent used for treating colon cancer. Using median-effect and apoptosis analyses, fluorescence microscopy and western blotting, the present study analyzed the association between GCFF and 5-FU in the human colon adenocarcinoma LoVo cell line. The effect of GCFF on the expression of chemotherapeutic agent-associated genes was also investigated. The results of the synergistic analysis revealed that GCFF exhibited a significant effect upon 5-FU-associated cytotoxicity within the LoVo cell line. This effect was observed over a broad dose-inhibition range (5-95%), but was particularly significant in the lower concentrations. The flow cytometry results revealed that low doses of GCFF or 5-FU induced S-phase arrest, as did a low-dose combination of the two drugs. After 48 h, GCFF significantly suppressed the expression levels of the chemotherapeutic agent resistance-associated genes within the colon cancer cells. The western blot analysis revealed that the combined effects of 5-FU and GCFF were due to a regulation of the B-cell lymphoma-2 family of proteins. The findings of the present study suggested that GCFF, when combined with 5-FU, has the potential to be a novel, chemotherapeutic compound for the treatment of colon cancer.

Development program for a 200 kW, CW gyrotron. Quarterly report No. 4, April-June 1980

International Nuclear Information System (INIS)

Tancredi, J.J.; Caplan, M.; Sandoval, J.J.; Weiss, W.

1980-01-01

The objective of this program is the design and development of a millimeter-wave device to produce 200 kW of continuous-wave power at 60 GHz. The device, which will be a gyrotron oscillator, will be compatible with power delivery to an electron-cyclotron plasma. Smooth control of rf power output over a 17 db range is required, and the device should be capable of operation into a severe time-varyinng rf load mismatch

Preoperative Capecitabine and Pelvic Radiation in Locally Advanced Rectal Cancer-Is it Equivalent to 5-FU Infusion Plus Leucovorin and Radiotherapy?

International Nuclear Information System (INIS)

Chan, Alexander K.; Wong, Alfred O.; Jenken, Daryl A.

2010-01-01

Purpose: The aim of this retrospective case-matching study was to compare the treatment outcomes and acute toxicity of preoperative radiotherapy (RT) with capecitabine vs. preoperative RT with intermittent 5-fluorouracil (5-FU) infusion, leucovorin, and mitomycin C in rectal cancer. Methods and Materials: We matched 34 patients who were treated with preoperative concurrent capecitabine and 50 Gy of RT by their clinical T stage (T3 or T4) and the tumor location (≤7 cm or >7 cm from the anal verge) with another 68 patients who were treated with preoperative intermittent 5-FU infusion, leucovorin, mitomycin C, and 50 Gy of RT for a comparison of the pathologic tumor response, local control, distant failure, and survival rates. Results: The pathologic complete response rate was 21% with capecitabine and 18% with 5-FU and leucovorin (p = 0.72). The rate of T downstaging after chemoradiation was 59% for both groups. The rate of sphincter-sparing resection was 38% after capecitabine plus RT and 43% after 5-FU plus RT (p = 0.67). At 3 years, there was no significant difference in the local control rate (93% for capecitabine and 92% for 5-FU and leucovorin), relapse-free rate (74% for capecitabine and 73% for 5-FU and leucovorin), or disease-specific survival rate (86% for capecitabine and 77% for 5-FU and leucovorin). The acute toxicity profile was comparable, with little Grade 3 and 4 toxicity. Conclusions: When administered with concurrent preoperative RT, both capecitabine and intermittent 5-FU infusion with leucovorin modulation provided comparable pathologic tumor response, local control, relapse-free survival, and disease-specific survival rates in rectal cancer.

Treating malfunction filtering bleb with repeated needling combined with adjunctive 5-FU after glaucoma filtration surgery

Directory of Open Access Journals (Sweden)

Yi Liu

2013-07-01

Full Text Available AIM: To evaluate the therapeutic efficacy of a repeated bleb needling technique combined with subconjunctival injection of 5-FU in eyes with previous glaucoma surgery that had malfunctional filtering blebs. METHODS: A retrospective review of 34 consecutive patients(34 eyesof repeated bleb needling combined with subconjunctival injection of 5-FU in eyes, which had malfunctional filtering blebs after previous glaucoma surgery in our hospital from March 2009 to February 2013 was performed. The intraocular pressures(IOP, shapes of filtering blebs and complications after surgery were analyzed. RESULTS: There was significant reduction of mean IOP from 35.51mmHg to 14.43mmHg(PCONCLUSION: Repeated needling with adjunctive 5-FU proved a highly effective, safe alternative to treat malfunctional filtering blebs after previous glaucoma surgery.

Studies of self-consistent field structure in a quasi-optical gyrotron

International Nuclear Information System (INIS)

Antonsen, T.M. Jr.

1993-04-01

The presence of an electron beam in a quasi-optical gyrotron cavity alters the structure of the fields from that of the empty cavity. A computer code has been written which calculates this alteration for either an electron beam or a thin dielectric tube placed in the cavity. Experiments measuring the quality factor of such a cavity performed for the case of a dielectric tube and the results agree with the predictions of the code. Simulations of the case of an electron beam indicate that self-consistent effects can be made small in that almost all the power leaves the cavity in a symmetric gaussian-like mode provided the resonator parameters are chosen carefully. (author) 6 figs., 1 tab., 13 refs

The process of dissemination of kung fu in west – between sense of loss and inevitability loss of sense

Directory of Open Access Journals (Sweden)

Fernando Dandoro Castilho Ferreira

2017-07-01

Full Text Available In this paper, we discuss aspects of the development process of Kung Fu in China and its subsequent spread to the West in the light of sociological theory of Norbert Elias. To meet this goal, we have structured the text into three parts. In the first, we present some elements of theory of Elias that are useful to study Kung Fu. In the second part of the article, in turn, bring some evidence about the Kung Fu diffusion process to the West, taking as a reading aid work “Shaolin Monastery” of Meir Shahar. The third and final part of the text, we suggest that the reception of Kung Fu in the West engenders a social process that combines elements of Chinese tradition and capitalist modernity, giving the practice a hybrid and ambiguous character.

Tai Chi and Kung-Fu practice maintains physical performance but not vascular health in young versus old participants.

Science.gov (United States)

McAnulty, Steven; McAnulty, Lisa; Collier, Scott; Souza-Junior, Tacito P; McBride, Jeffrey

2016-01-01

Kung-Fu and Tai Chi along with other martial arts are gaining popularity but studies examining the benefits of martial arts on physical fitness, vascular health, nutrition, and psychological wellness are limited. Aging is associated with declines in these health components. The objectives of this study were to examine whether Tai Chi and Kung-Fu training would maintain physical fitness, vascular health, and psychological wellness components on older versus younger practitioners. Seventeen subjects were recruited and divided into Young (age Kung-Fu maintains physical fitness in older compared to younger practitioners. However, age associated changes in cardiovascular stiffness, systolic blood pressure, and pain were not prevented.

Estudo do centro de massa e estabilidade de quatro posturas básicas do Kung-fu Pak Hok

OpenAIRE

Miranda,Pedro Jeferson; Brinatti,André Maurício; Silva,Silvio Luiz Rutz da; Godoy,Marino Luiz Michelin

2016-01-01

Este trabalho trata da análise dos centros de massa e do cálculo da estabilidade das quatro posturas básicas do Kung Fu Pak Hok. Embora a biomecânica tenha surgido em 1960, a sua aplicação em artes marciais, como no Kung Fu ainda é pouco frequente. Apesar de haver estudos de movimentos do Kung Fu, não há trabalhos sobre o centro de massa e a estabilidade para as posturas mais básicas. Este trabalho como objetivo descrever o centro de massa e a estabilidade das quatro posturas mais básicas do ...

Initial operation of a high-power quasi-optical gyrotron

International Nuclear Information System (INIS)

Fliflet, A.W.; Hargreaves, T.A.; Manheimer, W.M.; Fischer, R.P.; Barsanti, M.L.

1990-01-01

Results from the initial operating of a high-power quasi-optical gyrotron based on the 90-kV 50-A Varian VUW-8144 electron gun are reported. The output power and efficiency have been measured for a resonator mirror separation of 19.4 cm with a magnetic field of 4.95 T, corresponding to resonator output coupling of 1.9%, and for a resonator mirror separation of 21.4 cm with a magnetic field of 4.7 T, corresponding to a resonator output coupling of 3.1%. Operation was multimoded with 3--6 modes excited in the range of 125--130 GHz for the 4.95-T magnetic field. A peak efficiency of 15% at an output power of 161 kW was obtained for a gun voltage of 93 kV and a current of 12 A. A peak-output power of 364 kW at an efficiency of 10% was obtained at a voltage of 95.6 kV and 37.5 A

Drucken Images und mediale Diskurse über afrikanischen Fußball: Paternalismus, Rassismus und neoliberale Bewunderung

Directory of Open Access Journals (Sweden)

Kurt Wachter

2010-03-01

Full Text Available Die Wahrnehmung des afrikanischen Fußballs und seiner Spieler war und ist sowohl in den Stadien wie in den medialen Darstellungen von rassistischen Images aus der Zeit Kolonialismus geprägt. Der speziell in Europa konstatierbare Aufstieg des afrikanischen Fußballs im Zuge der Ökonomisierung und Globalisierung des Spiels brachte zwar neue Superstars hervor, alte Stereotype leben aber vor Ort wie im medialen Diskurs in transformierter Weise fort.

Towards the optimization of the thermal–hydraulic performance of gyrotron collectors

Energy Technology Data Exchange (ETDEWEB)

Savoldi, Laura; Bertani, Cristina [Dipartimento Energia, Politecnico di Torino, 10129 Torino (Italy); Cau, Francesca; Cismondi, Fabio [F4E, Barcelona (Spain); Gantenbein, Gerd; Illy, Stefan [Karlsruhe Institute of Technology (KIT), Institute for Pulsed Power and Microwave Technology (IHM), Kaiserstr. 12, 76131 Karlsruhe (Germany); Monni, Grazia [Dipartimento Energia, Politecnico di Torino, 10129 Torino (Italy); Rozier, Yoann [Thales Electron Devices, 78141 Vélizy-Villacoublay (France); Zanino, Roberto, E-mail: roberto.zanino@polito.it [Dipartimento Energia, Politecnico di Torino, 10129 Torino (Italy)

2015-11-15

Different configurations of water-cooled Cu collector for gyrotrons are investigated using the StarCCM + CFD code, aimed at optimizing its thermal–hydraulic (TH) performance. Although the current collectors show a good performance, the collector can be subjected to transient heat loads, due to the spent electron beam, of up to several tens of MW/m{sup 2}, and there is an interest to increase the gyrotron output power in the future. Furthermore, an optimized cooling will lead to improved reliability and lifetime of the collector. Starting from a hypervapotron (HV)-like collector, characterized by 100+ deep rectangular cavities with aspect ratio (AR) = 3, we present in the first part of the paper a single-cavity steady-state parametric analysis of the effect of AR on the heat exhaust capabilities. The investigation is then extended to other collector designs, including circumferential ribs and dimples, in order to assess the options for further improvements of the TH performance. The peak Cu temperature is computed by the code and its minimization is the target of the present optimization exercise. A self-consistent estimate of the heat transfer coefficient between collector and coolant is also obtained, which could be useful for fatigue and lifetime assessments. In the second part of the paper the most promising collector geometries identified in the first part are analyzed in the case of a transient heat load (vertical sweeping), first at the level of a single spatial period of the collector structure, then at the full-collector level. The results of the TH transient analysis are compared with both the results of the first part and with the transient purely thermal analysis of the full collector, showing for all geometries considered in this study a room for cooling efficiency improvement with respect to the HV-like design with AR = 3, at least in the operating conditions considered for this study (V ∼ 4 m/s, almost 100 °C sub-cooling).

Loss of ABCB4 attenuates the caspase-dependent apoptosis regulating resistance to 5-Fu in colorectal cancer.

Science.gov (United States)

Hu, Hanqing; Wang, Meng; Guan, Xu; Yuan, Ziming; Liu, Zheng; Zou, Chaoxia; Wang, Guiyu; Gao, Xu; Wang, Xishan

2018-02-28

The adenosine triphosphate-binding cassette (ABC) is a large group of proteins involved in material transportation, cellular homeostasis, and closely associated with chemoresistance. ATP-binding cassette protein B4 (ABCB4) is a member of ABCs which has a similar structure to ABCB1, but fewer researches were performed. The present study is aimed to investigate the putative mechanism of ABCB4 in 5-fluorouracil (5-Fu) resistance. Then, we found that ABCB4 was significantly down-regulated in the 5-Fu resistant HCT8 cell lines by polymerase chain reaction (PCR) and Western blot. The knockdown of ABCB4 by small interfering RNA decreased the apoptosis by 5-Fu in resistant HCT8R cell lines without influencing the proliferation. Also, we found a lower expression of cleaved caspase and PARP by Western blot after the knockdown of ABCB4. However, the knockdown of ABCB4 did not influence the proliferation and apoptosis. Furthermore, the histological detection of ABCB4 mRNA level in human colorectal cancer tissues and even in the recurrent tissues after 5-Fu single-agent chemotherapy was employed to provide more concrete evidence that ABCB4 may be a tumor suppressor gene to regulate chemoresistance in colorectal cancer. Moreover, a 109-patient cohort revealed that ABCB4 predicted a poor recurrence-free survival and overall survival. In summary, ABCB4 was down-regulated in the 5-Fu resistant cells and knockdown of ABCB4 alleviated the cell apoptosis and predicts a shorter recurrence-free survival and overall survival. © 2018 The Author(s).

MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer

DEFF Research Database (Denmark)

Afzal, Shoaib; Jensen, S; Vainer, B

2009-01-01

Methylenetetrahydrofolate reductase is a pivotal enzyme in folate metabolism and 5-fluorouracil (5-FU) cytotoxicity. Two common single-nucleotide polymorphisms (SNPs), MTHFR 677C>T (rs1801133) and 1298A>C (rs1801131), reduce enzyme activity. Initially, these SNPs were claimed to predict clinical...

Treatment results of chemoradiotherapy with 5-FU/CDGP for head and neck cancer

International Nuclear Information System (INIS)

Himei, Kengo; Katayama, Norihisa; Takemoto, Mitsuhiro; Kuroda, Masahiro; Nomiya, Shigenobu; Onoda, Tomoo; Tominaga, Susumu; Kanazawa, Susumu

2006-01-01

We investigated the safety and efficacy of alternative and concurrent chemoradiotherapy with 5-fluorouracil (FU)/nedaplatin (CDGP) for head and neck cancer. From January 2003 to August 2005, 19 patients with head and neck squamous cell carcinoma were treated in our institution. Alternative chemoradiotherapy (ACRT) was performed for 8 cases of nasopharyngeal cancer. Concurrent chemoradiotherapy (CCRT) was performed for 11 cases of other head and neck cancer. Median total dose of radiotherapy was 63 Gy. ACRT consisted of 5-FU at a dose of 500 mg/m 2 on days 1-5 and 28-32 and CDGP at a dose of 60 mg/m 2 on days 6 and 33. CCRT consisted of 5-FU at a dose of 500 mg/m 2 on days 1-4 and 28-31 and CDGP at a dose of 60 mg/m 2 on days 5 and 32. Median follow-up period was 13 months. CR+PR was admitted in five cases (63%) with ACRT, and in 9 cases (82%) with CCRT. Non-hematological adverse effects of grade 3 were admitted in eight cases (100%) of ACRT, and in 9 cases (82%) of CCRT. Chemoradiotherapy attained good results and non-hematological adverse effects were able to be managed by preserved treatment. (author)

Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms

Energy Technology Data Exchange (ETDEWEB)

Gaballah, Hanaa H., E-mail: hanaahibishy@hotmail.com [Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Tanta University, Tanta, 3111 (Egypt); Gaber, Rasha A. [Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Tanta University, Tanta, 3111 (Egypt); Mohamed, Darin A. [Histopathology Department, Faculty of Medicine, Tanta University, Tanta, 3111 (Egypt)

2017-02-01

Background: Although 5- Fluorouracil (5-FU) has exhibited effectiveness against cancer, novel therapeutic strategies are needed to enhance its antitumor efficiency and modulate its cytotoxity. Apigenin, a flavonoid present in fruits and vegetables, is a potent dietary phytochemical effective in cancer chemoprevention. Aim: This study was undertaken to investigate the potential synergistic antitumor activity of apigenin and 5-FU on Solid Ehrlich carcinoma (SEC). Methods: Eighty Swiss albino male mice were divided into four equal groups: vehicle treated control SEC, SEC + 5-FU, SEC + apigenin, SEC + 5-FU + apigenin. Beclin-1 and caspases 3, 9 and JNK activities were estimated by ELISA; mRNA expression levels of the antiapoptotic gene Mcl-1 were estimated using quantitative real-time RT-PCR, while tissue malondialdehyde (MDA), glutathione peroxidase and total antioxidant capacity were evaluated spectrophotometrically. A part of the tumor was examined for histopathological and Ki-67 immunohistochemistry analysis. Results: 5-FU and/or apigenin caused significant increase in tissue levels of Beclin-1, caspases 3, 9 and JNK activities, MDA with significant decrease in tumor volume, Mcl-1expression, tissue glutathione peroxidase and total antioxidant capacity and alleviated the histopathological changes with significant decrease of Ki-67 proliferation index compared to vehicle treated SEC control group. In conclusion: The combination of 5-FU and apigenin had a greater effect than each of 5-FU or apigenin alone against solid Ehrlich carcinoma in mice. - Highlights: • Apigenin potentiated 5-FU cytotoxicity in EAC solid tumor models in vivo. • It acted via autophagy stimulation, downregulating MCL-1 and Ki-67 expression. • It caused JNK activation and ROS accumulation; resulted in tumor growth inhibition. • Apigenin can be used as a co-adjuvant agent in cancer therapy.

Cold CO Gas in the Envelopes of FU Orionis-type Young Eruptive Stars

Energy Technology Data Exchange (ETDEWEB)

Kóspál, Á.; Ábrahám, P.; Moór, A. [Konkoly Observatory, Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences, Konkoly-Thege Miklós út 15-17, 1121 Budapest (Hungary); Csengeri, T.; Güsten, R. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Henning, Th. [Max-Planck-Institut für Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany)

2017-02-20

FU Orionis-type objects (FUors) are young stellar objects experiencing large optical outbursts due to highly enhanced accretion from the circumstellar disk onto the star. FUors are often surrounded by massive envelopes, which play a significant role in the outburst mechanism. Conversely, the subsequent eruptions might gradually clear up the obscuring envelope material and drive the protostar on its way to become a disk-only T Tauri star. Here we present an APEX {sup 12}CO and {sup 13}CO survey of eight southern and equatorial FUors. We measure the mass of the gaseous material surrounding our targets, locate the source of the CO emission, and derive physical parameters for the envelopes and outflows, where detected. Our results support the evolutionary scenario where FUors represent a transition phase from envelope-surrounded protostars to classical T Tauri stars.

System using a megawatt class millimeter wave source and a high-power rectenna to beam power to a suspended platform

Science.gov (United States)

Caplan, Malcolm; Friedman, Herbert W.

2005-07-19

A system for beaming power to a high altitude platform is based upon a high power millimeter gyrotron source, optical transmission components, and a high-power receiving antenna (i.e., a rectenna) capable of rectifying received millimeter energy and converting such energy into useable electrical power.

Precision Characterization of Gyrotron Window Materials

Energy Technology Data Exchange (ETDEWEB)

Jones, Charles R. [North Carolina Central Univ., Durham, NC (United States)

2012-12-31

The response of dielectric material to electromagnetic waves in the millimeter wavelength range (30 to 300 GHz) has received relatively little study and the processes that give rise to absorption in this region are often poorly understood. Understanding the origin of absorption at these wavelengths has basic significance for solid state physics as well as importance for development of technology in this region of the RF spectrum. This project has provided high-quality data on the temperature dependence of the dielectric loss in high-purity, semi-insulating silicon carbide (HPSI SiC), a material that holds much promise for application, especially in devices that must operate in the high power and high frequency regime. Comparison of this experimental data with theoretical predictions for various loss processes provides convincing evidence that the loss in HPSI SiC arises almost entirely from intrinsic lattice loss (ILL) as described by Garin. Fitting the data to this model yields an accurate value for the Debye temperature that characterizes crystalline SiC. In addition, our results refute a previous study(2) which reported much higher loss, attributed to the presence of free charge. The quality of the data acquired in this project is clear evidence for the value of the experimental technique that was employed here. This technique combines the excitation of a high-quality open resonator by a phase-locked backward wave oscillator (BWO) with use of a spectrum analyzer to measure the change in the resonator response curve when the sample is inserted. This system has demonstrated consistent results for very challenging measurements and does not suffer from the artifacts that often arise when using other techniques that rely on thermal sources. The low absorption loss found in HPSI SiC, when combined with its other outstanding material properties, e.g. high thermal conductivity, high tensile strength, and high carrier mobility, should provide incentive for designers to

WAVELET TRANSFORM ANALYSIS OF ELECTROMYOGRAPHY KUNG FU STRIKES DATA

Directory of Open Access Journals (Sweden)

Ana Carolina de Miranda Marzullo

2009-11-01

Full Text Available In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG analysis of such movements is non-trivial. This paper has three main goals: firstly, to investigate the differences in the EMG activity of muscles during strikes performed with and without impacts; secondly, to assess the advantages of using Sum of Significant Power (SSP values instead of root mean square (rms values when analyzing EMG data; and lastly to introduce a new method of calculating median frequency values using wavelet transforms (WMDF. EMG data of the deltoid anterior (DA, triceps brachii (TB and brachioradialis (BR muscles were collected from eight Kung Fu practitioners during strikes performed with and without impacts. SSP results indicated significant higher muscle activity (p = 0.023 for the strikes with impact. WMDF results, on the other hand, indicated significant lower values (p = 0. 007 for the strikes with impact. SSP results presented higher sensitivity than rms to quantify important signal differences and, at the same time, presented lower inter-subject coefficient of variations. The result of increase in SSP values and decrease in WMDF may suggest better synchronization of motor units for the strikes with impact performed by the experienced Kung Fu practitioners

[Knockdown of DNA-PKcs inhibits cell cycle and its mechanism of drug-resistant Bel7402/5-Fu hepatocellular carcinoma cells].

Science.gov (United States)

Li, Dayu; Liu, Yun; Yu, Chunbo; Liu, Xiping; Fan, Fang

2017-12-01

Objective To study the effect of the knock-down of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on the cell cycle of the multidrug-resistant (MDR) Bel7402/5-Fu hepatocellular carcinoma cells and its MDR mechanism. Methods After cationic liposome-mediated siDNA-PKcs oligonucleotide transfection, the drug sensitivity of Bel7402/5-Fu cells to 5-fluorouracil (5-Fu) and adriamycin (ADM) was determined by MTT assay; the cell cycle were detected by flow cytometry; meanwhile, the protein expressions of cell cycle-related proteins P21, cell cycle protein B1 (cyclin B1), cell cycle division protein 2 (CDC2) were tested by Western blotting; the expressions of ataxia telangiectasia mutated (ATM) and p53 at both mRNA and protein levels were detected by real-time PCR and Western blot analysis. Results The MTT results showed siDNA-PKcs increased the chemotherapeutic sensitivity of Bel7402/5-Fu cells to 5-Fu and ADM. The flow cytometric analysis showed siDNA-PKcs decreased the percentage of S-phase cells but increased the percentage of G2/M phase cells. Western blotting showed siDNA-PKcs increased the protein expression of P21 but decreased cyclinB1 and CDC2 proteins. In addition, siDNA-PKcs also increased the expressions of ATM and p53. Conclusion DNA-PKcs silencing increases P21 while decreases cyclin B1 and CDC2 expressions, and finally induces G2/M phase arrest in Bel7402/5-Fu cells, which may be related to ATM-p53 signaling pathway.

Asynchronous Sensor fuSion for Improved Safety of air Traffic (ASSIST), Phase I

Data.gov (United States)

National Aeronautics and Space Administration — SSCI proposes to develop, implement and test a collision detection system for unmanned aerial vehicles (UAV), referred to as the Asynchronous Sensor fuSion for...

Development of a dummy load and waveguide components for 1 MW CW gyrotron

Energy Technology Data Exchange (ETDEWEB)

Ioki, Kimihiro, E-mail: ioki@toyama-jp.com [Toyama Company Limited, 3816-1 Kishi, Ymakita-machi, Ashigarakami-gun, Kanagawa 258-0112 (Japan); Hiranai, Shinichi; Moriyama, Shinichi [Naka Fusion Institute, JAEA, 801-1, Mukoyama, Naka-shi, Ibaraki 311-0193 (Japan); Tanaka, Suguru [Toyama Company Limited, 3816-1 Kishi, Ymakita-machi, Ashigarakami-gun, Kanagawa 258-0112 (Japan)

2016-11-01

Highlights: • A dummy load is a required component for the electron cyclotron heating system to test and adjust a gyrotron or a transmission line in ITER and JT60SA. • A new design concept was developed considering reliable durability and long lifetime. • Linear movement is used as a main mechanism for the reflector to mitigate the heat deposition concentration instead of rotating reflector, and the vacuum boundary for the linear movement is simply made with bellows. • The distribution of the ceramic coating thickness is carefully optimized considering the heat deposition rate. • A prototypical dummy load will be manufactured and tested, following the design phase. - Abstract: A dummy load dissipates the radiofrequency power and is required for the electron cyclotron heating system to test and adjust a gyrotron or a transmission line in ITER and JT60SA. The dummy load is comprised of a water-cooled vacuum chamber and a reflector. The vacuum chamber has intensive cooling and the inside surface has a ceramic coating layer. It is important that the dummy load has reliable durability and long lifetime. Linear movement is used as a main mechanism for the reflector to mitigate the heat deposition concentration instead of rotating reflector. The vacuum boundary for the linear movement is simply made with bellows and the bellows is accessible from the outside. The distribution of the ceramic coating thickness is carefully optimized considering the heat deposition rate. Another critical issue is to minimize the back reflection of the RF power from the dummy load. However, it is desired to design the dummy load without the pre-dummy-load. A prototypical dummy load will be manufactured and tested, following the design phase.

"Welch Schauspiel! Aber ach! ein Schauspiel : Fußball und Theater

OpenAIRE

Thiergen, Peter

2009-01-01

Der Essay zeigt, wie eng Fußball und Schauspiel/Theater/Drama zusammenhängen. Dabei wird nicht nur einer Vielzahl von sprachlichen und insbesondere metaphorischen Entsprechungen nachgespürt, in denen sich die beiden Publikumsereignisse wechselseitig interpretieren, sondern auch gezeigt, auf welchen medialen Grundlagen, Erfahrungen und Rezeptionsdispositionen diese Entsprechungen beruhen.

5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin

OpenAIRE

Lund, Kaja; Olsen, Cathrine Elisabeth; Wong, Judith Jing Wen; Olsen, Petter Angell; Solberg, Nina Therese; Høgset, Anders; Krauss, Stefan; Selbo, Pål Kristian

2017-01-01

Background Development of resistance to 5-fluorouracil (5-FU) is a major problem in treatment of various cancers including pancreatic cancer. In this study, we reveal important resistance mechanisms and photochemical strategies to overcome 5-FU resistance in pancreatic adenocarcinoma. Methods 5-FU resistant (5-FUR), epithelial-to-mesenchymal-like sub-clones of the wild type pancreatic cancer cell line Panc03.27 were previously generated in our lab. We investigated the cytotoxic effect of the ...

Producing High-Performance, Stable, Sheared-Flow Z-Pinches in the FuZE project

Science.gov (United States)

Golingo, R. P.; Shumlak, U.,; Nelson, B. A.; Claveau, E. L.; Forbes, E. G.; Stepanov, A. D.; Weber, T. R.; Zhang, Y.; McLean, H. S.; Tummel, K. K.; Higginson, D. P.; Schmidt, A. E.; University of Washington (UW) Collaboration; Lawrence Livermore National Laboratory (LLNL) Collaboration

2017-10-01

The Fusion Z-Pinch Experiment (FuZE) has made significant strides towards generating high-performance, stable Z-pinch plasmas with goals of ne = 1018 cm-3 and T =1 keV. The Z-pinch plasmas are stabilized with a sheared axial flow that is driven by a coaxial accelerator. The new FuZE device has been constructed and reproduces the major scientific achievements the ZaP project at the University of Washington; ne = 1016 cm-3,T = 100 eV, r20 μs. These parameters are measured with an array of magnetic field probes, spectroscopy, and fast framing cameras. The plasma parameters are achieved using a small fraction of the maximum energy storage and gas injection capability of the FuZE device. Higher density, ne = 5×1017 cm-3, and temperature, T = 500 eV, Z-pinch plasmas are formed by increasing the pinch current. At the higher voltages and currents, the ionization rates in the accelerator increase. By modifying the neutral gas profile in the accelerator, the plasma flow from the accelerator is maintained, driving the flow shear. Formation and sustainment of the sheared-flow Z-pinch plasma will be discussed. Experimental data demonstrating high performance plasmas in a stable Z-pinches will be shown. This work is supported by an award from US ARPA-E.

1 megawatt, 100 GHz gyrotron study. Final report, March 21-September 1, 1983

International Nuclear Information System (INIS)

Dionne, N.J.; Mallavarpu, R.; Palevsky, A.

1983-01-01

This report provides the results of a design study on a gyrotron device employing a new type of hollow gyrobeam formation system and having a capability for delivering megawatt CW power at 100 GHz to an ECRH-heated, magnetically-confined plasma. The conceptual basis for the beam formation system is the tilt-angle gun (TAG) in which a conically-shaped electron beam is formed in a magnetically-shielded region and is then injected into the stray-field region of the main magnetic focusing system. Because fluid coolants can be accessed through the central pole of the TAG-type gun, rf interaction can be contemplated with cavity configurations not practical with the conventional MIG-type gyrobeam formation systems

Three-Dimensional Numerical Simulation of a 30-GHz Gyrotron Resonator With an Explicit High-Order Discontinuous-Galerkin-Based Parallel Particle-In-Cell Method

DEFF Research Database (Denmark)

Stock, Andreas; Neudorfer, Jonathan; Riedlinger, Marc

2012-01-01

Fast design codes for the simulation of the particle–field interaction in the interior of gyrotron resonators are available. They procure their rapidity by making strong physical simplifications and approximations, which are not known to be valid for many variations of the geometry and the operat...

Design considerations in achieving 1 MW CW operation with a whispering-gallery-mode gyrotron

International Nuclear Information System (INIS)

Felch, K.; Feinstein, J.; Hess, C.; Huey, H.; Jongewaard, E.; Jory, H.; Neilson, J.; Pendleton, R.; Pirkle, D.; Zitelli, L.

1989-09-01

Varian is developing high-power, CW gyrotrons at frequencies in the range 100 GHz to 150 GHz, for use in electron cyclotron heating applications. Early test vehicles have utilized a TE 15,2,1 interaction cavity, have achieved short-pulse power levels of 820 kW and average power levels of 80 kW at 140 GHz. Present tests are aimed at reaching 400 kW under CW operating conditions and up to 1 MW for short pulse durations. Work is also underway on modifications to the present design that will enable power levels of up to 1 MW CW to be achieved. 7 refs., 2 figs

Experimental measurements of competition between fundamental and second harmonic emission in a quasi-optical gyrotron

International Nuclear Information System (INIS)

Alberti, S.; Pedrozzi, M.; Tran, M.Q.; Hogge, J.P.; Tran, T.M.; Muggli, P.; Joedicke, B.; Mathews, H.G.

1990-04-01

A quasi-optical gyrotron (QOG) designed for operation at the fundamental (Ω ce ≅100 GHz) exhibits simultaneous emission at Ω ce and 2Ω ce (second harmonic). For a beam current of 4 A, 20% of the total RF power is emitted at the second harmonic. The experimental measurements show that the excitation of the second harmonic is only possible when the fundamental is present. The frequency of the second harmonic is locked by the frequency of the fundamental. Experimental evidence shows that when the second harmonic is not excited, total efficiency is enhanced. (author) 6 refs., 5 figs., 1 tab

Numerical optimization of quasi-optical mode converter for frequency step-tunable gyrotron

International Nuclear Information System (INIS)

Drumm, O.

2002-08-01

This work concentrates on the design of a quasi-optical mode converter for a frequency step-tunable gyrotron. Special attention is paid to the optimization of the conversion and forming of the exited wave of different frequencies inside the resonator. The investigations were part of the HGF-strategy-fonds-project ''Optimization of Tokamak Operation with controlled ECRH-Deposition''. In the resonator of the gyrotron modes can be exited at frequencies between 105 and 140 GHz. With the designed converter the desired field distribution at the output window for all frequencies will be approximately obtained. The newly gained knowledge and invented synthesis methods are applied to this practical example and verified. In this work, the waveguide antenna and the mirror system of the quasi-optical mode converter are presented separately from each other. At the beginning the synthesis of the aperture antenna for a frequency step-tunable design of the Vlasov-type as well as the Denisov-type is considered. As a conclusion of the investigation, the important parameters for the design of all antennas are summarized and the frequency behavior is compared. In the second part of this work new broadband design methods for the synthesis of the mirror surface are presented. These mirrors make an optimal wave forming for all frequencies equally possible. Therefore new quality criteria are introduced for the broadband evaluation of the mirror. Afterwards the surface is varied until the criteria reach an optimum. For the numerical optimization, in this work the gradient method and the extended Katsenelenbaum-Semenov algorithm are invented and applied. The efficient realization of the described algorithms on a computer is the significant point. The theoretical background of the presented methods for the synthesis of a mirror system is based on the general solution of the Helmholtz equation. Due to this, these methods can be utilized in other fields outside the microwave applications in

Fluorescence and computational studies of thymidine phosphorylase affinity toward lipidated 5-FU derivatives

Science.gov (United States)

Lettieri, R.; D'Abramo, M.; Stella, L.; La Bella, A.; Leonelli, F.; Giansanti, L.; Venanzi, M.; Gatto, E.

2018-04-01

Thymidine phosphorylase (TP) is an enzyme that is up-regulated in a wide variety of solid tumors, including breast and colorectal cancers. It is involved in tumor growth and metastasis, for this reason it is one of the key enzyme to be inhibited, in an attempt to prevent tumor proliferation. However, it also plays an active role in cancer treatment, through its contribution in the conversion of the anti-cancer drug 5-fluorouracil (5-FU) to an irreversible inhibitor of thymidylate synthase (TS), responsible of the inhibition of the DNA synthesis. In this work, the intrinsic TP fluorescence has been investigated for the first time and exploited to study TP binding affinity for the unsubstituted 5-FU and for two 5-FU derivatives, designed to expose this molecule on liposomal membranes. These molecules were obtained by functionalizing the nitrogen atom with a chain consisting of six (1) or seven (2) units of glycol, linked to an alkyl moiety of 12 carbon atoms. Derivatives (1) and (2) exhibited an affinity for TP in the micromolar range, 10 times higher than the parent compound, irrespective of the length of the polyoxyethylenic spacer. This high affinity was maintained also when the compounds were anchored in liposomal membranes. Experimental results were supported by molecular dynamics simulations and docking calculations, supporting a feasible application of the designed supramolecular lipid structure in selective targeting of TP, to be potentially used as a drug delivery system or sensor device.

Translasi Pencak Silat Kedalam Film Animasi (Studi Kasus Film Kung Fu Panda

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Riyo Ramadhan

2017-09-01

Full Text Available Sebagai tradisi yang telah membudaya dari sejak zaman dahulu kala, pencak silat lahir sebagai benteng kekuatan pertahanan diri sekaligus menjadi seni yang memperkaya khazanah kebudayaan bangsa Indonesia. Namun, kuatnya terpaan kebudayaan seni bela diri impor yang masuk (karate, kung fu, tae kwon do, muay thai, capoeira, dll, yang selalu didukung dengan berbagai kemasan media entertainment modern, membuat silat menjadi kalah populer bahkan di mata dan persepsi masyarakat Indonesia sendiri. Hal ini mengakibatkan para generasi muda memandang seni bela diri impor menjadi lebih superior ketimbang pencak silat. Jika hal ini terus berlangsung tanpa ada usaha untuk mengembangkan pencak silat melalui media modern, maka akan sangat sulit untuk mempertahankan dan mengembangkan tradisi ini di masa depan. Tujuan dari makalah ini ialah untuk membuktikan dan menggali potensi animasi sebagai media alternatif yang efektif untuk memvisualisasikan adegan dan cerita bertemakan pencak silat. Adapun studi kasus yang menjadi acuan dalam penelitian ialah film animasi “Kung Fu Panda”. Penelitian ini mengkaji studi kasus dengan menggunakan metode kualitatif deskriptif, lalu dianalisis dengan pendekatan analisis deskriptif untuk mengkaji dan mengidentifikasi pemasalahan dan solusi. Pembahasan dari makalah lebih ditekankan pada kekuatan penyampaikan cerita melalui gambar (visual storytelling yang efektif terkait dengan pencak silat. Hasil dari penelitian ialah cara penyampaian pesan yang efektif mengenai elemen dan esensi pencak silat sebagai bentuk translasinya kedalam film animasi. Pesan tersebut dapat disampaikan dengan menggunakan aspek narasi, gesture, dan simbol yang diakomodasi dengan aspek visual storytelling. Translating Pencak Silat Into An Animation Film (Case Study The Film Kung Fu Panda Abstract. A tradition that has been part of Indonesian culture since ancient times, pencak silat was born as a form of self-defense and at the same time has grown into an

Preoperative 5-FU, low-dose leucovorin, and radiation therapy for locally advanced and unresectable rectal cancer

International Nuclear Information System (INIS)

Minsky, Bruce D.; Cohen, Alfred M.; Enker, Warren E.; Saltz, Leonard; Guillem, Jose G.; Paty, Philip B.; Kelsen, David P.; Kemeny, Nancy; Ilson, David; Bass, Joanne; Conti, John

1997-01-01

Purpose: We report the local control and survival of two Phase I dose escalation trials of combined preoperative 5-fluorouracil (5-FU), low-dose leucovorin (LV), and radiation therapy followed by postoperative LV/5-FU for the treatment of patients with locally advanced and unresectable rectal cancer. Methods and Materials: A total of 36 patients (30 primary and 6 recurrent) received two monthly cycles of LV/5-FU (bolus daily x 5). Radiation therapy (50.40 Gy) began on day 1 in the 25 patients who received concurrent treatment and on day 8 in the 11 patients who received sequential treatment. Postoperatively, patients received a median of four monthly cycles of LV/5-FU. Results: The resectability rate with negative margins was 97%. The complete response rate was 11% pathologic and 14% clinical for a total of 25%. The 4-year actuarial disease-free survival was 67% and the overall survival was 76%. The crude local failure rate was 14% and the 4-year actuarial local failure rate was 30%. Crude local failure was lower in the four patients who had a pathologic complete response (0%) compared with those who either did not have a pathologic complete response (16%) or who had a clinical complete response (20%). Conclusion: Our preliminary data with the low-dose LV regimen reveal encouraging downstaging, local control, and survival rates. Additional follow-up is needed to determine the 5-year results. The benefit of downstaging on local control is greatest in patients who achieve a pathologic complete response

Nonstationary oscillation of gyrotron backward wave oscillators with cylindrical interaction structure

International Nuclear Information System (INIS)

Chen, Shih-Hung; Chen, Liu

2013-01-01

The nonstationary oscillation of the gyrotron backward wave oscillator (gyro-BWO) with cylindrical interaction structure was studied utilizing both steady-state analyses and time-dependent simulations. Comparisons of the numerical results reveal that the gyro-BWO becomes nonstationary when the trailing field structure completely forms due to the dephasing energetic electrons. The backward propagation of radiated waves with a lower resonant frequency from the trailing field structure interferes with the main internal feedback loop, thereby inducing the nonstationary oscillation of the gyro-BWO. The nonstationary gyro-BWO exhibits the same spectral pattern of modulated oscillations with a constant frequency separation between the central frequency and sidebands throughout the whole system. The frequency separation is found to be scaled with the square root of the maximum field amplitude, thus further demonstrating that the nonstationary oscillation of the gyro-BWO is associated with the beam-wave resonance detuning

The effect on the small bowel of 5-FU and oxaliplatin in combination with radiation using a microcolony survival assay

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Kjellén Elisabeth

2009-12-01

Full Text Available Abstract Background In locally advanced rectal cancer, 5-Fluorouracil (5-FU-based chemoradiation is the standard treatment. The main acute toxicity of this treatment is enteritis. Due to its potential radiosensitizing properties, oxaliplatin has recently been incorporated in many clinical chemoradiation protocols. The aim of this study was to investigate to what extent 5-FU and oxaliplatin influence the radiation (RT induced small bowel mucosal damage when given in conjunction with single or split dose RT. Methods Immune competent balb-c mice were treated with varying doses of 5-FU, oxaliplatin (given intraperitoneally and total body RT, alone or in different combinations in a series of experiments. The small bowel damage was studied by a microcolony survival assay. The treatment effect was evaluated using the inverse of the slope (D0 of the exponential part of the dose-response curve. Results In two separate experiments the dose-response relations were determined for single doses of RT alone, yielding D0 values of 2.79 Gy (95% CI: 2.65 - 2.95 and 2.98 Gy (2.66 - 3.39, for doses in the intervals of 5-17 Gy and 5-10 Gy, respectively. Equitoxic low doses (IC5 of the two drugs in combination with RT caused a decrease in jejunal crypt count with significantly lower D0: 2.30 Gy (2.10 - 2.56 for RT+5-FU and 2.27 Gy (2.08 - 2.49 for RT+oxaliplatin. Adding both drugs to RT did not further decrease D0: 2.28 Gy (1.97 - 2.71 for RT+5-FU+oxaliplatin. A clearly higher crypt survival was noted for split course radiation (3 × 2.5 Gy compared to a single fraction of 7.5 Gy. The same difference was seen when 5-FU and/or oxaliplatin were added. Conclusion Combining 5-FU or oxaliplatin with RT lead to an increase in mucosal damage as compared to RT alone in our experimental setting. No additional reduction of jejunal crypt counts was noted when both drugs were combined with single dose RT. The higher crypt survival with split dose radiation indicates a

Rezension von: Ulf Gebken, Söhnke Vosgerau (Hg.: Fußball ohne Abseits. Ergebnisse und Perspektiven des Projekts ‚Soziale Integration von Mädchen durch Fußball‘. Wiesbaden: Springer VS 2014.

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Robert Claus

2014-12-01

Full Text Available Seit 2006 wurden im Rahmen des vom Deutschen Fußball-Bund durchgeführten Modellprojektes „Soziale Integration von Mädchen durch Fußball“ an über 200 Standorten Schul-AGs in sogenannten Brennpunktbezirken aufgebaut. Im vorliegenden Sammelband beleuchten die Autor/-innen ausführlich die Funktion von Sport für die pädagogische Kompetenzvermittlung. Zudem erbringen sie einen umfassenden Projektbericht und leisten ein Plädoyer für die Modernisierung des Verhältnisses zwischen Schule und Vereinen, Lehrplan und Ehrenamt. Somit stellt das Buch, wie auch das Projekt, einen enorm wichtigen Beitrag zur Geschlechtergerechtigkeit im Sport dar. Gleichzeitig jedoch liest sich eine Reihe an Texten etwas zu sperrig für den Bericht einer Praxisforschung, und Begriffe im Feld der ‚Integration’ bleiben schwammig.

Clinical research on disciplinarian and character of treatment of zang-fu in syndrome differentiation on insomnia

Institute of Scientific and Technical Information of China (English)

凌丽; 薛金伟; 东贵荣

2005-01-01

Objective To investigate the therapeutic effect of insomnia with zang-fu in syndrome differentiation. Methods Seventy patients with insomnia according to the diagnostic sequence were randomly divided into two groups, the treatment group and the control group. Two groups received the therapeutic methods of acupuncture in syndrome differentiation and general acupuncture separately. After two courses of treatment and one month's follow-up, therapeutic effect was evaluated through statistical analysis. Resulds The therapeutic effects of the treatment group and the control group have significant differences which have statistical significance. Conclusion Zang-fu in syndrome differentiation may enhance the clinical therapeutic effect of insomnia.

The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer.

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Joshua E Allen

Full Text Available Phenylbutyl isoselenocyanate (ISC-4 is an Akt inhibitor with demonstrated preclinical efficacy against melanoma and colon cancer. In this study, we sought to improve the clinical utility of ISC-4 by identifying a synergistic combination with FDA-approved anti-cancer therapies, a relevant and appropriate disease setting for testing, and biomarkers of response. We tested the activity of ISC-4 and 19 FDA-approved anticancer agents, alone or in combination, against the SW480 and RKO human colon cancer cell lines. A synergistic interaction with cetuximab was identified and validated in a panel of additional colon cancer cell lines, as well as the kinetics of synergy. ISC-4 in combination with cetuximab synergistically reduced the viability of human colon cancer cells with wild-type but not mutant KRAS genes. Further analysis revealed that the combination therapy cooperatively decreased cell cycle progression, increased caspase-dependent apoptosis, and decreased phospho-Akt in responsive tumor cells. The synergism between ISC-4 and cetuximab was retained independently of acquired resistance to 5-FU in human colon cancer cells. The combination demonstrated synergistic anti-tumor effects in vivo without toxicity and in the face of resistance to 5-FU. These results suggest that combining ISC-4 and cetuximab should be explored in patients with 5-FU-resistant colon cancer harboring wild-type KRAS.

In vivo 19F-MRS observation of 5-FU metabolism in fatty liver induced by choline-deficient diet

International Nuclear Information System (INIS)

Otsuka, Hideki; Harada, Masafumi; Nishitani, Hiromu; Koga, Keiko.

1996-01-01

Using 19 F-MRS, 5-FU metabolism was investigated in rat fatty liver. Fatty liver was induced by choline-deficient diet (CD diet). This study showed differences in 5-FU metabolism between normal and fatty liver. After laparotomy, a surface coil was placed directly on the liver surface. Spectra were continuously obtained after injection of 5-FU 100 mg/kg body weight via a catheter inserted into femoral vein. We made MRI and 1 H-MRS study to examine the lipid accumulation. Histological study was also performed using HE (hematoxylin-eosin) and oil red stain. The livers of rats fed a CD diet showed very high intensity on T 1 -WI. 1 H-MRS was very useful in deteminating the fat content because the fat ratio demonstrated by 1 H-MRS is well correlated to histological findings. In 19 F-MRS, we recognized the following four peaks: 5-FU, FBAL, Fnct (fluoronucleotide) and FUPA. The decrease of 5-FU was not very apparent, but compared to the normal liver, the formation of Fnct increased and the formation of FBAL was suppressed in fatty liver. The rats fed a CD diet for four weeks showed a higher Fnct peak and lower FBAL peak compared with the results of rats fed a CD diet for two weeks. In a CD diet group, liver cell degeneration and necrotic changes were observed histologically. It is reported that cell degeneration is followed by cell proliferation in fatty liver induced by a choline deficient diet, and the high Fnct peak found in our study may reflect this phenomenon. The high Fnct peak on 19 F-MRS may correspond to recovering reaction from liver injury like fatty liver. (author)

The role of effective mass and hand speed in the performance of kung fu athletes compared with nonpractitioners.

Science.gov (United States)

Neto, Osmar Pinto; Magini, Marcio; Saba, Marcelo M F

2007-05-01

The main goal of this article is to quantify the contribution of effective mass (me) and handspeed (shi) on the palm strike performance of kung fu athletes (kung fu group) compared with nonpractitioners (control group). All subjects were asked to strike a basketball. Hand and ball speed (sbf) were determined by high-speed video analysis. The value for me was determined by an equation that does not depend upon postimpact measurement of the hand speed. The results show that kung fu athletes had greater shi (6.67 [SD 1.42] m/s), p = 0.042), higher me (2.62 [SD 0.33] kg, p = 0.004), and greater sbf (9.00 [SD 1.89] m/s), p = 0.004) than the nonpractitioners (5.04 [SD 0.57] m/s, 1.33 [SD 0.19] kg, and 5.72 [SD 0.44] m/s, respectively). Comparing the average values obtained for me and hand and forearm mass (m), it was found that for the control group me is statistically equal to m (p = 0.917), whereas for the kung fu group me is significant greater than m (p = 0.003). It is suggested that for impacts against heavier objects, the effective mass would be the main factor to distinguish a martial arts-trained from an untrained subject.

High power rf amplifiers for accelerator applications: The large orbit gyrotron and the high current, space charge enhanced relativistic klystron

International Nuclear Information System (INIS)

Stringfield, R.M.; Fazio, M.V.; Rickel, D.G.; Kwan, T.J.T.; Peratt, A.L.; Kinross-Wright, J.; Van Haaften, F.W.; Hoeberling, R.F.; Faehl, R.; Carlsten, B.; Destler, W.W.; Warner, L.B.

1991-01-01

Los Alamos is investigating a number of high power microwave (HPM) sources for their potential to power advanced accelerators. Included in this investigation are the large orbit gyrotron amplifier and oscillator (LOG) and the relativistic klystron amplifier (RKA). LOG amplifier development is newly underway. Electron beam power levels of 3 GW, 70 ns duration, are planned, with anticipated conversion efficiencies into RF on the order of 20 percent. Ongoing investigations on this device include experimental improvement of the electron beam optics (to allow injection of a suitable fraction of the electron beam born in the gun into the amplifier structure), and computational studies of resonator design and RF extraction. Recent RKA studies have operated at electron beam powers into the device of 1.35 GW in microsecond duration pulses. The device has yielded modulated electron beam power approaching 300 MW using 3-5 kW of RF input drive. RF powers extracted into waveguide have been up to 70 MW, suggesting that more power is available from the device than has been converted to-date in the extractor

The Effect of 5 FU on the Expression of Transforming Growth Factor Beta-1 (Tgf-1 in Cultured Tendon Cells

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Zeynep Karacor Altuntas

2014-10-01

Full Text Available This study investigated the effect of the treatment with 1 min exposures to 5-fluorouracil (5-FU  on the expression of TGF-beta 1 in cultured tendon cells. Fibroblasts cultured from the flexor tendons of dog paws were treated with 3 different doses of 5-FU ( control, 5-15-25 mgr /ml for 1 minute.  After 5-FU exposure  the expression of TGF –beta 1 were tested by real time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR at 3rd and 7th days. There were no statistically significant differences in the expression levels of the TGF-b1 gene between the control group and all other groups on day 3 and 7 (p>0.05.However, when the percentage changes in the TGF-BETA1 gene expression on days 3–7 were compared, there were statistically significant differences and this was maximally observed with 89% +12 (p<0.05 in the group treated with 25-mg/ml 5-FU.  We conclude that 1min. 5-FU application may be  sufficient to prevent adhesions in tendon healing by limiting the expression of TGF-BETA1. 

Dielectric properties during electron irradiation of alternative materials for gyrotron windows

International Nuclear Information System (INIS)

Vila, R.; Ibarra, A.; Hodgson, E.R.

1996-01-01

Recent work on high power gyrotron windows has focused interest on some homopolar insulators as alternatives to sapphire due to their combined low dielectric loss and high thermal conductivity. The two main candidates at this moment, CVD diamond and high resistivity silicon, have been studied. As an indicator of their radiation behaviour, loss tangent and permittivity at about 15 GHz have been measured under 1.8 MeV electron irradiation at RT. In the case of silicon the previously observed radiation-induced decrease of loss tangent has been confirmed reaching a lower saturation level of 3.5 x 10 -5 at higher doses, and falling with increasing frequency. An even more important observation is that the sensitivity to ionizing radiation dropped by 4 orders of magnitude due to the radiation dose. First results for diamond are also promising, only a small degradation at relatively short times being seen with no further changes up to the maximum dose used. (orig.)

Fuels planning: science synthesis and integration; environmental consequences fact sheet 12: Water Erosion Prediction Project (WEPP) Fuel Management (FuMe) tool

Science.gov (United States)

William Elliot; David Hall

2005-01-01

The Water Erosion Prediction Project (WEPP) Fuel Management (FuMe) tool was developed to estimate sediment generated by fuel management activities. WEPP FuMe estimates sediment generated for 12 fuel-related conditions from a single input. This fact sheet identifies the intended users and uses, required inputs, what the model does, and tells the user how to obtain the...

Design of a double-anode magnetron-injection gun for the W-band gyrotron

Science.gov (United States)

Jang, Kwang Ho; Choi, Jin Joo; So, Joon Ho

2015-07-01

A double-anode magnetron-injection gun (MIG) was designed. The MIG is for a W-band 10-kW gyrotron. Analytic equations based on adiabatic theory and angular momentum conservation were used to examine the initial design parameters such as the cathode angle, and the radius of the beam emitting surface. The MIG's performances were predicted by using an electron trajectory code, the EGUN code. The beam spread of the axial velocity, Δvz/vz, obtained from the EGUN code was observed to be 1.34% at α = 1.3. The cathode edge emission and the thermal effect were modeled. The cathode edge emission was found to have a major effect on the velocity spread. The electron beam's quality was significantly improved by affixing non-emissive cylinders to the cathode.

Optical spectroscopy of Z Canis Majoris, V1057 Cygni, and FU Orionis - Accretion disks and signatures of disk winds

Science.gov (United States)

Welty, Alan D.; Strom, Stephen E.; Edwards, Suzan; Kenyon, Scott J.; Hartmann, Lee W.

1992-01-01

High resolution, high SNR optical spectra have been used to investigate the hypothesis that in outburst, FU Ori objects are self-luminous accretion disks whose light dominates at optical and near-IR wavelengths. Strong evidence has been found for linewidth versus wavelength correlation in good agreement with model predictions for Z CMa and V1057 Cyg, but not for FU Ori itself. Linewidth varies continuously with wavelength at optical wavelengths in the former two objects, In the case of FU Ori, it is argued that a combination of strong wind components to spectral lines, and surface gravity possibly being lower than that of supergiants, conceals the underlying linewidth versus wavelength relationship. A marginal correlation is found between linewidth and lower excitation potential in all three objects. Synthetic disk spectra are subtracted from observed spectral, and remarkably good fits are found for all three objects for wavelengths longer than about 5000 A.

Low Impact Development Intensive Rural Construction Planning in Xu Fu Village Ningbo, China: Planning Review through Rural Resilience Perspective

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Roosmayri Lovina Hermaputi

2017-08-01

Full Text Available Xu Fu Village Ningbo LID Intensive Rural Construction Planning is a cooperation project between Zhejiang University and Ningbo Institute of Technology which named "12th Five-Year National Science and Technology support program-the comprehensive demonstration of the key technology of the beautiful rural construction in the rapid urbanization area of the Yangtze River Delta". This plan focuses on intensive rural construction as part of rural development and construction project that applies the principles of low impact development. Xu Fu Village located in the Yangtze River Delta Region. Currently, the rural growth brings the high impact of development, as a result of rapid urbanization growth arising several issues, such as low land use efficiency, dispersed rural residence, homestead occupies more, rural roads covering over, etc. Meanwhile, Xu Fu village wishes to develop its tourism potential. Thus, the intensive rural construction should be done to avoid the severe effect. The project result hopefully can improve the quality and level of rural residential planning, design, and construction; improve their living environment; save construction land and water use; and improve energy efficiency. The aim of this study is to review the Low Impact Development (LID Intensive Rural Construction in Xu Fu Village, Ningbo City through the rural resilience perspective. This paper will describe the project plan first, then review it through rural resilience perspective. This paper will elaborate the rural resilience theory and then review the rural resiliency through two parts; the first part is identifying rural resilience in rural infrastructure development based on the criteria created by Ayyob S. and Yoshiki Y. (2014, about urban resiliency criteria, and then the second part is reviewing Xu Fu Village resilience through Arup Resilience Qualities (2012, considering three rural resilience domain (economy, ecology, and cultural.

Expression and Role of Oct3/4 in Injury-Repair Process of Rat Alveolar Epithelium after 5-Fu Treatment

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Wen-ya Li

2017-01-01

Full Text Available Objective. We aimed to investigate how the embryonic stem cell-related gene Oct3/4 changes during the injury-repair process of distal pulmonary epithelium induced by 5-fluorouracil (5-Fu. Methods. We have developed the lung injury model induced by 5-Fu and observed the dynamic changes of Oct3/4 by indirect immunofluorescence, Western blot, and quantitative real-time PCR. Immunofluorescence double staining was used to compare the positions of Oct3/4(+ cells and other reported alveolar epithelial stem cells. Results. Oct3/4(+ cells were not found in normal rat lung epithelial cells. However, after treatment with 5-Fu, Oct3/4(+ cells appeared at 12 h, reached the peak at 24 h, then decreased at 48 h, and eventually disappeared at 72 h. Oct3/4 was localized in the nucleus. We found that the sites of Clara cell secretory protein and surfactant protein-C dual positive cells were apparently different from Oct3/4(+ cells. Conclusions. Our results revealed that, in rat alveolar epithelium, expression of Oct3/4 could be induced after treatment with 5-Fu, then decreased gradually, and was silenced following the alveolar epithelial differentiation. We hold that Oct3/4(+ cells are lung stem cells, which can provide new evidence for identification and isolation of lung epithelial stem cells.

Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy.

Science.gov (United States)

Marks, Eric I; Tan, Carlyn; Zhang, Jun; Zhou, Lanlan; Yang, Zhaohai; Scicchitano, Angelique; El-Deiry, Wafik S

2015-01-01

We present 2 patients with metastatic colorectal cancer who had progressed despite treatment with first-line FOLFOX and second-line FOLFIRI combination chemotherapy regimens. After failing these fluoropyrimidine-based regimens, both patients received additional cytotoxic and targeted therapies with eventual disease progression. These therapies included capecitabine plus dabrafenib and trametinib, regorafenib monotherapy, and regorafenib with panitumumab. After exhausting available options, both patients were offered regorafenib with either 5-fluorouracil (5-FU) or capecitabine. These therapies are individually approved for the treatment of colorectal cancer but have not yet been studied in combination. This regimen produced stable disease in both patients with acceptable toxicity. One patient continued therapy for 17 months. Although these patients previously progressed during treatment with regorafenib, capecitabine or 5-FU, the combination had some activity in both cases of refractory metastatic colorectal cancer and may be considered in the palliative setting. In bedside-to-bench cell culture experiments performed after the clinical observations, we observed sensitivity of human colorectal cancer cell lines (N = 4) to single agent regorafenib or 5-FU and evidence of synergy with the combination therapy. Synergistic effects were noted in colorectal cancer cells with KRAS mutation, BRAF mutation, and p53 mutation, as well as mismatch repair deficient cells. Regorafenib suppressed Mcl-1 and Bcl-XL in treated cancer cells that may have contributed to the anticancer efficacy including in combination with 5-FU. The safety and efficacy of regorafenib with 5-FU or capecitabine in combination should be further investigated as a therapy for patients with refractory metastatic colorectal cancer, including individuals who had progressed on regorafenib monotherapy.

The three-dimensional particle-in-cell simulation analysis of cavity of high power subterahertz pulsed gyrotron

International Nuclear Information System (INIS)

Ito, Koyu; Jiang, Weihua

2013-01-01

High power sub-terahertz pulsed gyrotrons for Collective Thomson Scattering (CTS) diagnostics of fusion plasmas are being developed. The typical target parameters are: output power of 100-200 kW, operation frequency of 300 GHz, and pulsed length > 10 us. In order to support experimental development, numerical simulations were carried out by using Particle-In-Cell (PIC) code MAGIC. The oscillation mode of the electromagnetic radiation was selected as TE_1_5_,_2, for which the beam parameters and cavity dimensions were determined accordingly. The simulation results have showed maximum power of 144 kW at oscillation frequency of 292.80 GHz, with oscillation efficiency of 22.15%. (author)

Dynamic nuclear polarization by frequency modulation of a tunable gyrotron of 260GHz.

Science.gov (United States)

Yoon, Dongyoung; Soundararajan, Murari; Cuanillon, Philippe; Braunmueller, Falk; Alberti, Stefano; Ansermet, Jean-Philippe

2016-01-01

An increase in Dynamic Nuclear Polarization (DNP) signal intensity is obtained with a tunable gyrotron producing frequency modulation around 260GHz at power levels less than 1W. The sweep rate of frequency modulation can reach 14kHz, and its amplitude is fixed at 50MHz. In water/glycerol glassy ice doped with 40mM TEMPOL, the relative increase in the DNP enhancement was obtained as a function of frequency-sweep rate for several temperatures. A 68 % increase was obtained at 15K, thus giving a DNP enhancement of about 80. By employing λ/4 and λ/8 polarizer mirrors, we transformed the polarization of the microwave beam from linear to circular, and achieved an increase in the enhancement by a factor of about 66% for a given power. Copyright © 2015 Elsevier Inc. All rights reserved.

Radio-chemo-therapy with 5FU and cisplatin for bladder cancer after TUR-bladder

International Nuclear Information System (INIS)

Schuchardt, U.; Birkenhake, S.; Leykam, S.; Martus, P.; Sauer, R.

1996-01-01

Purpose/Objective: To determine toxicity and efficacy of radio-chemo-therapy (RCT) with 5FU and cisplatin in patients with bladder cancer. Endpoints are initial response, cystectomy-rates and overall-survival. Materials and Methods: From 11/93 to 1/95 13 patients suffering from bladder cancer were first treated with TUR-bladder (TURB). Patient characteristics were as follows: Within 6 weeks after operation the pelvis was irradiated with 54.0 Gy (median) in conventional fractionation (10 MV photons 4-field-box). The bladder was boosted up to 59.4 Gy (median) in isocentric rotation technique. 7 patients were treated with 45 Gy paraaortal. During the first and 5th treatment week chemotherapy (CT) was simultaneously given: 800 mg/m 2* d CISPLATIN as bolus-infusion 30 min prior to RT. 2 months later a further TURB was performed for restaging. Cystectomy was recommended, if invasive cancer was found at this time. Acute hematological and gastrointestinal toxicity was recorded according to the WHO-criteria. Results: At least 81% (e.g. 75% of 2nd course) of CT was applied in 10/13 patients. Median doses were 3500 mg/m 2 5FU and 200 mg/m 2 CISPLATIN. Acute toxicity to bladder and bowel reached grade 2 WHO only. Hematotoxicity (median values) and results ar shown in the following table. Conclusion: Concomitant RCT with 5FU and CISPLATIN seems to be a promising modality for organ-preserving therapy of bladder cancer. Preliminary results show sufficient effect and acceptable toxicity. Since patient number is still low, further investigation is recommended

Cold test measurements on components of the 1 MW, 140 GHz, CW gyrotron for the stellarator Wendelstein 7-X

International Nuclear Information System (INIS)

Dammertz, G.; Alberti, S.; Arnold, A.; Giguet, E.; LeGoff, Y.; Thumm, M.

2001-01-01

For the development of a 1 MW, 140 GHz gyrotron for CW operation which will be installed at the stellarator facility Wendelstein 7-X at IPP Greifswald, a collaboration between different European research institutes and an industrial company has been established. In order to prove the proper functioning of the millimeter wave components installed in the gyrotron -- such as the cavity, the waveguide taper and the quasioptical mode converter -- these components should be cold tested, preferably before installation. However, due to lack of time as well as long delivery times, this was not possible. Therefore, two units of the quasioptical mode converter and the cavity were fabricated with identical geometry, one of those being used for measurements on the low power test device. To perform these cold tests for tapers and mode converters, the gyrotron cavity output mode has to be simulated. This means that a high order rotating mode (TE 28,8 mode) must be generated at low power. This can be achieved by means of a mode generator consisting of two mirrors and a coaxial cavity with a perforated outer wall. Before applying the mode generator to the components, its proper behavior and the accurate alignment of the system must be verified either by radiation pattern measurements or k-spectrometer measurements. As the coupling through the holes of the k-spectrometer is extremely low, a special vector network analyzer with a dynamic range of at least 100 dB had to be developed. This has been achieved by integration of a phase locked backward-wave oscillator with a line width of 100 Hz and an output power of 10 mW. A non-destructive measurement of the resonance frequency and the quality factor of the cavity does not seem possible. The second cavity will be prepared for the cold measurement by drilling a small radial hole into its wall in the plane of the field maximum. This hole is then used for the input coupling. The accuracy required for this hole is rather critical. The

Comparative analysis of gyrotron backward-wave oscillators operating at different cyclotron harmonics

International Nuclear Information System (INIS)

Yeh, Y.S.; Chang, T.H.; Wu, T.S.

2004-01-01

A comparative analysis between the fundamental and second cyclotron harmonics of gyrotron backward-wave oscillators (gyro-BWOs) is presented. The simulation results reveal that nonlinear field contraction is a common feature for both harmonic interactions. Besides, the electron transit angle, used to characterize the axial modes of the fundamental harmonic TE 11 mode at the start-oscillation conditions, is found to be applicable even for the second harmonic TE 21 mode. Each axial mode of either the fundamental harmonic TE 11 or the second harmonic TE 21 modes is maintained at a constant value of the electron transit angle while changing the operating parameters, such as magnetic field and beam voltage. Extensive numerical calculations are conducted for the start-oscillation currents and tuning properties. Moreover, single-mode operating regimes are suggested where the second harmonic TE 21 gyro-BWO could generate a considerable output power, comparing with the fundamental harmonic TE 11 gyro-BWO

Non-viral genetic transfection of rat Schwann cells with FuGENE HD© lipofection and AMAXA© nucleofection is feasible but impairs cell viability.

Science.gov (United States)

Kraus, Armin; Täger, Joachim; Kohler, Konrad; Haerle, Max; Werdin, Frank; Schaller, Hans-Eberhard; Sinis, Nektarios

2010-11-01

To determine transfection efficiency of FuGENE HD© lipofection and AMAXA© nucleofection on rat Schwann cells (SC). The ischiadic and median nerves of 6-8 week old Lewis rats were cultured in modified melanocyte-growth medium. SCs were genetically transfected with green fluorescent protein (GFP) as reporter gene using FuGENE HD© lipofection and AMAXA© nucleofection. Transfection rates were determined by visualization of GFP fluorescence under fluorescence microscopy and cell counting. Transfected cell to non-transfected cell relation was determined. Purity of Schwann cell culture was 88% as determined by immunohistologic staining. Transfection rate of FuGENE HD© lipofection was 2%, transfection rate of AMAXA© nucleofection was 10%. With both methods, Schwann cells showed pronounced aggregation behavior which made them unfeasible for further cultivation. Settling of Schwann cells on laminin and poly-L-ornithine coated plates was compromised by either method. Non-viral transfection of rat SC with FuGENE HD© lipofection and AMAXA© nucleofection is basically possible with a higher transfection rate for nucleofection than for lipofection. As cell viability is compromised by either method however, viral transfection is to be considered if higher efficiency is required.

Numerical Simulation of Single-anode and Double-anode Magnetron Injection Guns for 127.5 GHz 1 MW Gyrotron

Science.gov (United States)

Singh, Udaybir; Kumar, Nitin; Kumar, Anil; Purohit, Laxmi Prasad; Sinha, Ashok Kumar

2011-07-01

This paper presents the design of two types of magnetron injection guns (MIG's) for 1 MW, 127.5 GHz gyrotron. TE24,8 mode has been chosen as the operating mode. In-house developed code MIGSYN has been used to estimate the initial gun parameters. The electron trajectory tracing program EGUN and in-house developed code MIGANS have been used to optimize the single-anode and the double-anode design for 80 kV, 40 A MIG. The parametric analysis of MIG has also been presented. The advantages and the disadvantages of each kind of configuration have been critically examined.

5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin.

Science.gov (United States)

Lund, Kaja; Olsen, Cathrine Elisabeth; Wong, Judith Jing Wen; Olsen, Petter Angell; Solberg, Nina Therese; Høgset, Anders; Krauss, Stefan; Selbo, Pål Kristian

2017-12-19

Development of resistance to 5-fluorouracil (5-FU) is a major problem in treatment of various cancers including pancreatic cancer. In this study, we reveal important resistance mechanisms and photochemical strategies to overcome 5-FU resistance in pancreatic adenocarcinoma. 5-FU resistant (5-FUR), epithelial-to-mesenchymal-like sub-clones of the wild type pancreatic cancer cell line Panc03.27 were previously generated in our lab. We investigated the cytotoxic effect of the endosomal/lysosomal-localizing photosensitizer TPCS 2a (fimaporfin) combined with light (photochemical treatment, PCT) using MTS viability assay, and used fluorescence microscopy to show localization of TPCS 2a and to investigate the effect of photodamage of lysosomes. Flow cytometric analysis was performed to investigate uptake of photosensitizer and to assess intracellular ROS levels. Expression and localization of LAMP1 was assessed using RT-qPCR, western blotting, and structured illumination microscopy. MTS viability assay was used to assess the effect of combinations of 5-FU, chloroquine (CQ), and photochemical treatment. Expression of CD105 was investigated using RT-qPCR, western blotting, flow cytometry, and fluorescence microscopy, and co-localization of TPCS 2a and anti-CD105-saporin was assessed using microscopy. Lastly, the MTS assay was used to investigate cytotoxic effects of photochemical internalization (PCI) of the anti-CD105-immunotoxin. The 5-FUR cell lines display hypersensitivity to PCT, which was linked to increased uptake of TPCS 2a , altered lysosomal distribution, lysosomal photodamage and increased expression of the lysosomal marker LAMP-1 in the 5-FUR cells. We show that inhibition of autophagy induced by either chloroquine or lysosomal photodamage increases the sensitivity to 5-FU in the resistant cells. The three 5-FUR sub-clones overexpress Endoglin (CD105). Treatment with the immunotoxin anti-CD105-saporin alone significantly reduced the viability of the CD105

Translasi Pencak Silat Kedalam Film Animasi (Studi Kasus Film Kung Fu Panda)

OpenAIRE

Riyo Ramadhan; Hafiz Aziz Ahmad; Alvanov Z. Mansoor

2017-01-01

Sebagai tradisi yang telah membudaya dari sejak zaman dahulu kala, pencak silat lahir sebagai benteng kekuatan pertahanan diri sekaligus menjadi seni yang memperkaya khazanah kebudayaan bangsa Indonesia. Namun, kuatnya terpaan kebudayaan seni bela diri impor yang masuk (karate, kung fu, tae kwon do, muay thai, capoeira, dll), yang selalu didukung dengan berbagai kemasan media entertainment modern, membuat silat menjadi kalah populer bahkan di mata dan persepsi masyarakat Indonesia sendiri. Ha...

浅析脏腑理论与方剂配伍的关系%A brief Analysis on the Relationship between the Zang Fu Theory and Compatibility of Formula

Institute of Scientific and Technical Information of China (English)

齐放; 徐大鹏; 李明

2013-01-01

Each Zang-Fu organ has its own physiological characteristics .The relationships of inter-promotion and inter-restraint exist a-mong the Zang-Fu organs.Compatibility of formula can be modified according to physiological characteristics of the Zang and Fu organs and the relationships of inter-promotion and inter-restraint among the Zang and Fu organs .The Zang and Fu theory is an effective way to research the compatibility of formula and guide its clinical modification .%每个脏腑具有各自的生理特点，脏腑之间存在着相生相克的关系，方剂可以仿照脏腑的生理特点和脏腑之间生克制化的关系组方配伍。脏腑理论是研究方剂配伍和指导临证组方的有效途径。

Commissioning a Megawatt-class Gyrotron with Collector Potential Depression

Science.gov (United States)

Lohr, J.; Cengher, M.; Gorelov, Y. A.; Ponce, D.; Prater, R.

2013-10-01

A 110 GHz depressed collector gyrotron has been installed on the DIII-D tokamak. The commissioning process rapidly achieved operation at full parameters, 45 A and 94 kV total voltage, with 29 kV depression. Although short pulse, 2 ms, factory testing demonstrated 1.2 MW at 41% electrical efficiency, long pulse testing at DIII-D achieved only 33% efficiency at full power parameters, for pulse lengths up to 10 s. Maximum generated power was ~950 kW, considerably below the 1.2 MW target. During attempts to increase the power at 5 s pulse length, it was noted that the collector cooling water was boiling. This led to the discovery that 14 of the 160 cooling channels in the collector had been blocked by braze material during manufacture of the tube. The locations of blocked channels were identified using infrared imaging of the outside of the collector during rapid changes in the cooling water temperature. Despite these difficulties, the rf beam itself was of very high quality and the stray rf found calorimetrically in the Matching Optics Unit, which couples the Gaussian rf beam to the waveguide, was only 2% of the generated power, about half that of our previous best quality high power beam. Details of the power measurements and collector observations will be presented. Work supported by the US DOE under DE-FC02-04ER54698.

Enteric coated HPMC capsules plugged with 5-FU loaded microsponges: a potential approach for treatment of colon cancer

Directory of Open Access Journals (Sweden)

Ankita Gupta

2015-09-01

Full Text Available The work was aimed at developing novel enteric coated HPMC capsules (ECHC plugged with 5 Florouracil (5-FU loaded Microsponges in combination with calcium pectinate beads. Modified quasi-emulsion solvent diffusion method was used to formulate microsponges based on 32 factorial design and the effects of independent variables (volume of organic solvent and Eudragit RS100 content on the dependent variables (Particle size, %EE & % CDR were determined. The optimized microsponges (F4 were characterized by SEM, PXRD, TGA and were plugged along with calcium pectinate beads in HPMC capsules and the HPMC capsules were further coated with enteric polymer Eudragit L 100 (Ed-L100 and/ or Eudrgit S 100 (Ed-S 100 in different proportions. In vitro release study of ECHC was performed in various release media sequentially SGF for 2 h, followed by SIF for the next 6 h and then in SCF (in the presence and absence of pectinase enzyme for further 16 h. Drug release was retarded on coating with EdS-100 in comparison to blend of EdS-100: EdL-100 coating. The percentage of 5-FU released at the end of 24 h from ECHC 3 was 97.83 ± 0.12% in the presence of pectinase whereas in control study it was 40.08 ± 0.02% drug. The optimized formulation was subjected to in vivo Roentgenographic studies in New Zealand white rabbits to analyze the in vivo behavior of the developed colon targeted capsules. Pharmacokinetic studies in New Zealand white rabbits were conducted to determine the extent of systemic exposure provided by the developed formulation in comparison to 5-FU aqueous solutions. Thus, enteric coated HPMC capsules plugged with 5-FU loaded microsponges and calcium pectinate beads proved to be promising dosage form for colon targeted drug delivery to treat colorectal cancer.

Nedaplatin and 5-FU combined with radiation in the treatment for esophageal cancer

International Nuclear Information System (INIS)

Yamanaka, Hideharu; Motohiro, Takayuki; Michiura, Taku; Asai, Akira; Mori, Tsuyoshi; Hioki, Koshiro

1998-01-01

A series of patients with esophageal cancer was treated with chemotherapeutic regimens of the new antitumor platinum preparation nedaplatin plus 5-FU in combination with radiation therapy, and the therapeutic responses, side effects, and complications were clinically assessed. There were 2 patients with a complete response and 11 patients with a partial response, hence, a response rate of 76.5%. Major adverse reactions were those of hematological toxicity and included leukopenia (13 patients, 76.5%), thrombocytopenia (8 patients, 47.1%), and lowered serum hemoglobin concentration (9 patients, 52.9%). The leukopenia and thrombocytopenia, though of a grade 3 severity in 3 and 2 patients, respectively, subsided spontaneously in all affected cases. Gastrointestinal adverse reactions were mild and included appetite loss in 7 patients (41.2%) and nausea in 2 patients (11.8%). The only abnormality in renal function observed was a slight elevation of serum creatinine in one patient. The combined therapy of chemotherapy with nedaplatin and 5-FU plus radiation produced a high response rate in the treatment of carcinoma of the esophagus and was associated with reduced gastrointestinal and renal toxicity. The results indicate the combined therapy with nedaplatin to be clinically useful. (author)

Enhancement of oscillation characteristics of a gyrotron by a built-in quasi-optical mode converter

International Nuclear Information System (INIS)

Hayashi, Kenichi; Mitsunaka, Yoshika; Komuro, Mitsuo

1994-01-01

Oscillation characteristics are analyzed experimentally and numerically by using two gyrotrons with a power level of 500 kW, a conventional tube and a tube with a built-in quasi-optical mode converter. Both tubes have a 120 GHz, TE 12,2 cavity of the same geometry and a single disk alumina window. The quasi-optical mode converter consists of an α-cut launcher and five mirrors. In the conventional tube, reflection of the competing mode at the output window prevents the main mode from oscillating stably in the operation region predicted by the design. Mode selectivity of the quasi-optical mode converter removes the influence of the reflection on the oscillation. Consequently, the experimental results in the tube with the quasi-optical mode converter are in good agreement with the design values. (author)

Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways

Directory of Open Access Journals (Sweden)

Chen J

2014-07-01

Full Text Available Jiezhong Chen,1,2 Renfu Shao,3 Li Li,4 Zhi Ping Xu,4 Wenyi Gu4 1School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, 2Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, 3GeneCology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, Queensland, 4Australian Institute of Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, Australia Abstract: Colon cancer is the third most common cancer and the third largest cause of cancer-related death. Fluorouracil (5-FU is the front-line chemotherapeutic agent for colon cancer. However, its response rate is less than 60%, even in combination with other chemotherapeutic agents. The side effects of 5-FU also limit its application. Nanoparticles have been used to deliver 5-FU, to increase its effectiveness and reduce side effects. Another common approach for colon cancer treatment is targeted therapy against the phosphoinositide 3-kinase (PI3K/protein kinase B (Akt pathway. A recently-invented inhibitor of this pathway, BEZ-235, has been tested in several clinical trials and has shown effectiveness and low side effects. Thus, it is a very promising drug for colon cancer treatment. The combination of these two drugs, especially nanoparticle-packed 5-FU and BEZ-235, has not been studied. In the present study, we demonstrated that nanoparticles of layered double hydroxide (LDH loaded with 5-FU were more effective than a free drug at inhibiting colon cancer cell growth, and that a combination treatment with BEZ-235 further increased the sensitivity of colon cancer cells to the treatment of LDH-packed 5-FU (LDH-5-FU. BEZ-235 alone can decrease colon cancer HCT-116 cell viability to 46% of the control, and the addition of LDH-5-FU produced a greater effect, reducing cell survival to 8% of the control. Our data indicate that the combination therapy of

The Many Sides of Happy Lim: aka Hom Ah Wing, Lin Jian Fu, Happy Lum, Lin Chien Fu, Hom Yen Chuck, Lam Kin Foo, Lum Kin Foo, Hom, Lim Goon Wing, Lim Gin Foo, Gin Foo Lin, Koon Wing Lim, Henry Chin, Lim Ying Chuck, Lim Ah Wing, et. al.

Directory of Open Access Journals (Sweden)

Gordon H. Chang

2010-03-01

Full Text Available

Known to the FBI, INS, and IRS as Mr. Ah Wing Hom, he was also Lin Jian Fu, Jian Fu (Tough Guy, or just Fu to the readers of the many poems and short stories he published in Chinese over four decades in the twentieth century. And to still others, primarily English-readers of his writing, he was Happy Lim, an ironic, even tragically bizarre name, as his life was far from pleasant. On New Year's Day 1986, he died alone in a dingy San Francisco Chinatown bachelor hotel suffering from a bacterial infection and a chronic blood disorder that had required the amputation of all his toes the year before. He was seventy-eight years of age and had spent most of his life within blocks of where he died.

Posmodernisme Dalam Novel Generation X: Tales For Accelerated Culture Dan Bilangan Fu

OpenAIRE

Azmi, Nurul Nayla

2013-01-01

This research is entitled Postmodernism in Novel Generation X: Tale of Accelerated Culture and Bilangan Fu which analyze postmodernism as the concept in both novel. As generally known, that the fast growing of recent life has effecting the human’s life that change continuity started from traditional, modern and then to the latest which postmodernism. In the changing of each stage, human life also encounters the changing which may seen from happening social phenomenon. In the stage of postmo...

Mechanical reliability of current alumina and beryllia ceramics used in microwave windows for gyrotrons

International Nuclear Information System (INIS)

Becher, P.F.; Ferber, M.K.

1983-02-01

The mechanical reliability was evaluated for the alumina and beryllia ceramics now used as microwave windows in the high-power (greater than or equal to 200 kW) high-frequency (greater than or equal to 60 GHz) gyrotron tubes being developed for plasma heating in fusion systems. Analysis of the stresses generated in the various window configurations and tube operating conditions indicated that significant tensile stresses are generated in the ceramic window by dielectric heating. As a result, we characterized the static and dynamic fatigue behavior and the inert strength distributions for these two ceramics (i.e., fatigue studies included the behavior in the fluorocarbon fluid used for window cooling at 22 and 48 0 C and in both air (65% relative humidity) and distilled water at 22 0 C. These data were then analyzed in order to construct reliability diagrams for these materials

State-of-the-art of high power gyro-devices and free electron masers. Update 2015

Energy Technology Data Exchange (ETDEWEB)

Thumm, Manfred [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Inst. fuer Hochleistungsimpuls- und Mikrowellentechnik, Programm Fusion

2016-07-01

Gyrotron oscillators (gyromonotrons) are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH), electron cyclotron current drive (ECCD), stability control and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. The maximum pulse length of commercially available 140 GHz, megawatt- class gyrotrons employing synthetic diamond output windows is 30 minutes (CPI and European KIT-CRPP-TED collaboration). The world record parameters of the European megawatt-class 140 GHz gyrotron are: 0.92 MW output power at 30 min. pulse duration, 97.5% Gaussian mode purity and 44% efficiency, employing a single-stage depressed collector (SDC) for energy recovery. A maximum output power of 1.5 MW in 4.0 s pulses at 45% efficiency was generated with the JAEA-TOSHIBA 110 GHz gyrotron. The Japan 170 GHz ITER gyrotron achieved 1 MW, 800 s at 55% efficiency and holds the energy world record of 2.88 GJ (0.8 MW, 60 min.) and the efficiency record of 57% for tubes with an output power of more than 0.5 MW. The Russian 170 GHz ITER gyrotron achieved 0.99 (1.2) MW with a pulse duration of 1000 (100) s and 53 (53) % efficiency. The prototype tube of the European 2 MW, 170 GHz coaxial-cavity gyrotron achieved in short pulses the record power of 2.1 MW at 46% efficiency and 96% Gaussian mode purity. Gyrotrons with pulsed magnet for various short-pulse applications deliver P{sub out}=210 kW with τ=20 μs at frequencies up to 670 GHz (η≅20%), P{sub out}=5.3 kW at 1 THz (η=6.1%), and P{sub out}=0.5 kW at 1.3 THz (η=0.6%). Gyrotron oscillators have also been successfully used in materials processing. Such technological applications require gyrotrons with the following parameters: f ≥ 24 GHz, P{sub out}=4-50 kW, CW, η≥30%. This paper gives an update of the experimental achievements related to the development of high power gyrotron oscillators for long-pulse or CW operation and pulsed gyrotrons for

[Effects of intravenous alimentation on adjuvant chemotherapy--an experimental study on the distribution of 5-FU after injection of tegafur (2)].

Science.gov (United States)

Kimoto, M; Nagano, H; Sano, K

1987-10-01

The stomach, small and large intestines, heart, lungs, bone and kidneys were removed from 48 Sato lung cancer-bearing rats used in the previous experiments and given 90 mg/kg of tegafur (FT-207) by single intravenous administration and tissue 5-FU and FT-207 concentrations were measured. FT-207 concentration in the alimentary canal was somewhat lower than the blood concentration, but both were lowered in parallel. 5-FU concentration in the stomach and large intestines showed virtually identical changes in both IVH and PO groups, but IVH group tended to have higher concentration. IVH group showed higher values than PO group anytime, particularly in the large intestines. A reduction of the side effects on the digestive system via intravenous alimentation was thought due to the elimination of mechanical stimulation via a cessation of oral feeding. 5-FU concentration in the bone was highest in PO group at six hours after administration and blood concentration changes were parallel, but there was virtually no change in IVH group. Maximum values were found one hour after administration and slowly declined thereafter; at 24 hrs the values were 0.059 +/- 0.013 microgram/g, relatively high compared to the PO group at 0.041 +/- 0.022 microgram/g. In the present study under intravenous alimentation, the concentration changes were slight in spite of 5-FU maximum concentration being lower than that by oral feeding and the long-term high concentration which was maintained; this is thought to be a disadvantageous action with regard to the bone marrow. FT-207 concentration in the kidney, heart and lungs was the same as that for the blood, with a gradual reduction in IVH group. 5-FU concentration was the same for the kidneys and IVH group quickly reached to the high levels compared to PO group with only slight changes thereafter. Effects of continuous water load might be involved but not clear.

Spectral energy distribution analysis of class I and class II FU Orionis stars

Energy Technology Data Exchange (ETDEWEB)

Gramajo, Luciana V.; Gómez, Mercedes [Observatorio Astronómico, Universidad Nacional de Córdoba, Argentina, Laprida 854, 5000 Córdoba (Argentina); Rodón, Javier A., E-mail: luciana@oac.uncor.edu, E-mail: mercedes@oac.uncor.edu, E-mail: jrodon@eso.org [European Southern Observatory, Alonso de Córdova 3107, Vitacura, Casilla 19001, Santiago 19 (Chile)

2014-06-01

FU Orionis stars (FUors) are eruptive pre-main sequence objects thought to represent quasi-periodic or recurring stages of enhanced accretion during the low-mass star-forming process. We characterize the sample of known and candidate FUors in a homogeneous and consistent way, deriving stellar and circumstellar parameters for each object. We emphasize the analysis in those parameters that are supposed to vary during the FUor stage. We modeled the spectral energy distributions of 24 of the 26 currently known FUors, using the radiative transfer code of Whitney et al. We compare our models with those obtained by Robitaille et al. for Taurus class II and I sources in quiescence periods by calculating the cumulative distribution of the different parameters. FUors have more massive disks: we find that ∼80% of the disks in FUors are more massive than any Taurus class II and I sources in the sample. Median values for the disk mass accretion rates are ∼10{sup –7} M {sub ☉} yr{sup –1} versus ∼10{sup –5} M {sub ☉} yr{sup –1} for standard young stellar objects (YSOs) and FUors, respectively. While the distributions of envelope mass accretion rates for class I FUors and standard class I objects are similar, FUors, on average, have higher envelope mass accretion rates than standard class II and class I sources. Most FUors (∼70%) have envelope mass accretion rates above 10{sup –7} M {sub ☉} yr{sup –1}. In contrast, 60% of the classical YSO sample has an accretion rate below this value. Our results support the current scenario in which changes experimented by the circumstellar disk explain the observed properties of these stars. However, the increase in the disk mass accretion rate is smaller than theoretically predicted, although in good agreement with previous determinations.

Optimizing the coupling of output of a quasi-optical gyrotron owing to a diffraction grating with ellipsoidal support

International Nuclear Information System (INIS)

Hogge, J.P.

1993-12-01

The output scheme of a quasi-optical gyrotron has been optimized in order to produce a gaussian output microwave beam suitable for transmission over long distances. The technique which has been applied consists of substituting one of the mirrors of the Fabry-Perot resonator in which the particle-wave interaction takes place by a diffraction grating placed in the -1 order Littrow mount and designed such that only orders -1 and 0 can propagate. In such a configuration, the diffraction angle of the order -1 coincides exactly with the incidence direction, thus providing a feedback in the cavity, whereas the order 0 constitutes the output of the resonator. A theoretical study of the power content in each diffracted order of a planar grating of infinite extent with equally spaced linear grooves as a function of the grating parameters has been performed. It has been shown that parameter domains can be found, which provide appropriate efficiencies in both orders for an application on a quasi-optical gyrotron. The Littrow condition was then adapted in order to match the spherical wavefronts of a gaussian beam incident on a possibly non-planar surface. The grooves become thus curvilinear and are no longer equally spaced. Measurements made on a cold test stand have confirmed the validity of the Littrow condition extension and allowed to determine its limits. It has also been shown that this type of cavity provides a mode having an optimal gaussian content and giving a minimal cavity transmission. The angular dispersion of the grating leads to a higher cavity transmission and to a slightly lower gaussian content for the adjacent resonator modes. The fundamental eigenmode electric field profile has been measured inside the cavity and is similar to that of an equivalent resonator made with two spherical mirrors. (author) figs., tabs., 141 refs

State-of-the-art of high power gyro-devices and free electron masers 1994

International Nuclear Information System (INIS)

Thumm, M.

1995-04-01

At present, gyrotron oscillators are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH) and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. 140 GHz gyrotrons with output power P out =0.54 MW, pulse length τ=3.0 s and efficiency η=42% are commercially available. Total efficiencies around 50% have been achieved using single-stage depressed collectors. Diagnostic gyrotrons deliver P out =40 kW with τ=40 μs at frequencies up to 650 GHz (η≥4%). Recently, gyrotron oscillators have also been successfully used in material processing and plasma chemistry. Such technological applications require gyrotrons with the following parameters: f≥24 GHz, P out =10-50 kW, CW, η≥30%. This paper reports on achievements and problems related to the development of very high power mm-wave gyrotrons for long pulse or CW operation and describes the microwave technological pecularities of the different development steps. In addition, this work gives a short overview of the present development of gyrotrons for technological applications, relativistic gyrotrons, quasi-optical gyrotrons, cyclotron autoresonance masers (CARMs), gyro klystrons, gyro-TWT amplifiers, gyrotwystron amplifiers, gyro-BWO's, peniotrons and free electron masers (FEMs). The most impressive FEM output parameters are: P out =2 GW, τ=20 ns, η=13% at 140 GHz (LLNL) and P out =15 kW, τ=20 μs, η=5% in the range from 120 to 900 GHz (UCSB). (orig.) [de

Comparison of force, power, and striking efficiency for a Kung Fu strike performed by novice and experienced practitioners: preliminary analysis.

Science.gov (United States)

Neto, Osmar Pinto; Magini, Marcio; Saba, Marcelo M F; Pacheco, Marcos Tadeu Tavares

2008-02-01

This paper presents a comparison of force, power, and efficiency values calculated from Kung Fu Yau-Man palm strikes, when performed by 7 experienced and 6 novice men. They performed 5 palm strikes to a freestanding basketball, recorded by high-speed camera at 1000 Hz. Nonparametric comparisons and correlations showed experienced practitioners presented larger values of mean muscle force, mean impact force, mean muscle power, mean impact power, and mean striking efficiency, as is noted in evidence obtained for other martial arts. Also, an interesting result was that for experienced Kung Fu practitioners, muscle power was linearly correlated with impact power (p = .98) but not for the novice practitioners (p = .46).

Design of 95 GHz gyrotron based on continuous operation copper solenoid with water cooling

International Nuclear Information System (INIS)

Borodin, Dmitri; Ben-Moshe, Roey; Einat, Moshe

2014-01-01

The design work for 2nd harmonic 95 GHz, 50 kW gyrotron based on continuous operation copper solenoid is presented. Thermionic magnetron injection gun specifications were calculated according to the linear trade off equation, and simulated with CST program. Numerical code is used for cavity design using the non-uniform string equation as well as particle motion in the “cold” cavity field. The mode TE02 with low Ohmic losses in the cavity walls was chosen as the operating mode. The Solenoid is designed to induce magnetic field of 1.8 T over a length of 40 mm in the interaction region with homogeneity of ±0.34%. The solenoid has six concentric cylindrical segments (and two correction segments) of copper foil windings separated by water channels for cooling. The predicted temperature in continuous operation is below 93 °C. The parameters of the design together with simulation results of the electromagnetic cavity field, magnetic field, electron trajectories, and thermal analyses are presented

Design of 95 GHz gyrotron based on continuous operation copper solenoid with water cooling

Energy Technology Data Exchange (ETDEWEB)

Borodin, Dmitri; Ben-Moshe, Roey; Einat, Moshe [Department of Electrical and Electronic Engineering, Ariel University, Ariel 40700 (Israel)

2014-07-15

The design work for 2nd harmonic 95 GHz, 50 kW gyrotron based on continuous operation copper solenoid is presented. Thermionic magnetron injection gun specifications were calculated according to the linear trade off equation, and simulated with CST program. Numerical code is used for cavity design using the non-uniform string equation as well as particle motion in the “cold” cavity field. The mode TE02 with low Ohmic losses in the cavity walls was chosen as the operating mode. The Solenoid is designed to induce magnetic field of 1.8 T over a length of 40 mm in the interaction region with homogeneity of ±0.34%. The solenoid has six concentric cylindrical segments (and two correction segments) of copper foil windings separated by water channels for cooling. The predicted temperature in continuous operation is below 93 °C. The parameters of the design together with simulation results of the electromagnetic cavity field, magnetic field, electron trajectories, and thermal analyses are presented.

State-of-the-art of high power gyro-devices and free electron masers

International Nuclear Information System (INIS)

Thumm, M.

1993-10-01

At present, gyrotron oscillators are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH) and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. 140 GHz gyrotrons with output power P out = 0.58 MW, pulse length τ = 2.0 s and efficiency η = 34% are commercially available. Diagnostic gyrotrons deliver P out = 40 kW with τ = 40 μs at frequencies up to 650 GHz (η ≥ 4%). Recently, gyrotron oscillators have also been successfully used in material processing and plasma chemistry. Such technological applications require gyrotrons with the following parameters: f ≥ 28 GHz, P out = 10-30 kW, CW, η ≥ 30%. This paper reports on achievements and problems related to the development of very high power mm-wave gyrotrons for long pulse or CW operation and describes the microwave technological pecularities of the different development steps. In addition, this work gives a short overview of the present development of gyrotrons for technological applications, quasi-optical gyrotrons, cyclotron autoresonance masers (CARMs), gyro-klystrons, gyro-TWT amplifiers, gyro-BWO's and free electron masers (FEMs). The most impressive FEM output parameters are: P out = 2 GW, τ = 20 ns, η = 13% at 140 GHz (LLNL) and P out = 15 kW, τ = 20 μs, η = 5% in the range from 120 to 900 GHz (UCSB). (orig.) [de

Electromyographic Study of a Sequence of Yau-Man Kung Fu Palm Strikes with and without Impact.

Science.gov (United States)

Neto, Osmar Pinto; Magini, Marcio; Pacheco, Marcos T T

2007-01-01

IN MARTIAL ARTS AND CONTACT SPORTS, STRIKES ARE OFTEN TRAINED IN TWO DIFFERENT WAYS: with and without impacts. This study aims to compare the electromyographical activity (EMG) of the triceps brachii (TB), biceps brachii (BB) and brachioradialis (BR) muscles during strikes with and without impacts. Eight Yau-Man Kung Fu practitioners participated in the experiment. Each participant performed 5 sequences of 5 consecutive KF Yau-Man palm strikes with no impact intercalated with 5 sequences of 5 repetitions targeting a KF training shield. Surface EMG signals were obtained from the TB, BB, and RB for 3.0 seconds using an eight-channel module with a total amplifier gain of 2000 and sampled at 3500 Hz. The EMG analyses were done in the time (rms) and frequency (wavelet) domains. For the frequency domain, Morlet wavelet power spectra were obtained and an original method was used to quantify statistically significant regions on the power spectra. The results both in the time and frequency domains indicate a higher TB and BR muscle activity for the strikes with impacts. No significant difference was found for the BB in the two different scenarios. In addition, the results show that the wavelet power spectra pattern for the three analysed muscles obtained from the strikes with and without impacts were similar. Key pointsEMG analysis of a sequence of Kung Fu strikes demonstrates higher Triceps Brachii and Brachioradialis muscle activity for strikes with impact than strikes without impact.An original reliable method for quantifying EMG wavelet transform results is presented.EMG wavelet power spectra describe muscle roles during a Kung Fu sequence of strikes.

Numerical investigation of collector cooling for a 1 MW ITER gyrotron operated with vertical sweeping

Energy Technology Data Exchange (ETDEWEB)

Savoldi, Laura; Bertani, Cristina [Dipartimento Energia, Politecnico di Torino (Italy); Cau, Francesca; Cismondi, Fabio [Fusion for Energy, Barcelona (Spain); Gantenbein, Gerd; Illy, Stefan [KIT, Karlsruhe (Germany); Monni, Grazia [Dipartimento Energia, Politecnico di Torino (Italy); Zanino, Roberto, E-mail: roberto.zanino@polito.it [Dipartimento Energia, Politecnico di Torino (Italy)

2015-11-15

The present gyrotron designs for EC plasma heating in nuclear fusion reactors require the safe exhaust of a power comparable to that injected into the plasma, in order to keep the maximum temperature below the acceptable value of 300 °C. In this paper, the commercial computational fluid dynamics (CFD) software STAR-CCM+{sup ®} is used to analyze the thermal performance of the annular copper collector of a 1 MW ITER gyrotron, equipped with a hypervapotron structure made of annular fins with rectangular cavities of aspect ratio (depth/width) = 3, cooled by highly subcooled (90–100 °C) pressurized water flowing at ∼4 m/s. It is assumed that the simple vertical sweeping strategy is used to reduce the very high peak heat flux on the collector (up to 30 MW/m{sup 2} transient, 5 MW/m{sup 2} time average), due to the spent electron beam. The 2D steady-state conjugate heat transfer problem is solved assuming azimuthal symmetry and accounting for 2-phase flow. The single-cavity flow and heat transfer problem is considered first, to optimize the mesh and the selection of the turbulence model. For the operating conditions considered in this paper, the full collector (100+ cavities) solution shows that boiling occurs only in a limited number of cavities close to the peaks of the heat flux, with the vapor remaining trapped in the bottom of the cavities, i.e. no full hypervapotron regime should be achieved in these operating conditions. The steady-state analysis allows the numerical evaluation of the heat transfer coefficients between Cu and water; these are then used as input for the simplified, purely thermal (solid only) analysis of the actual transient problem for the full collector. The results of the simplified model, which allows a huge reduction of the computational effort, are successfully benchmarked against those of a comprehensive thermal–hydraulic simulation. The computed peak Cu temperature is below the acceptable limit under the steady-state (time averaged

Translation Methods Used In Writing Indonesian Subtitles Of “Kung Fu Panda Holiday”

OpenAIRE

NURMALLAH, HERDIANTI

2013-01-01

In Indonesia, western movies that are spoken in English make the need for Indonesian subtitles increase. To make subtitles in different language, translation has an important role. The translator must use appropriate methods to produce good translation. This study aims to find out the kinds of translation methods used in writing Indonesian subtitles of the movie “Kung Fu Panda Holiday” by using Newmark's theory (1988). This study uses descriptive qualitative approach with document analysis. T...

Low-order-mode harmonic multiplying gyrotron traveling-wave amplifier in W band

International Nuclear Information System (INIS)

Yeh, Y. S.; Chen, C. H.; Yang, S. J.; Lai, C. H.; Lin, T. Y.; Lo, Y. C.; Hong, J. W.; Hung, C. L.; Chang, T. H.

2012-01-01

Harmonic multiplying gyrotron traveling-wave amplifiers (gyro-TWAs) allow for magnetic field reduction and frequency multiplication. To avoid absolute instabilities, this work proposes a W-band harmonic multiplying gyro-TWA operating at low-order modes. By amplifying a fundamental harmonic TE 11 drive wave, the second harmonic component of the beam current initiates a TE 21 wave to be amplified. Absolute instabilities in the gyro-TWA are suppressed by shortening the interaction circuit and increasing wall losses. Simulation results reveal that compared with Ka-band gyro-TWTs, the lower wall losses effectively suppress absolute instabilities in the W-band gyro-TWA. However, a global reflective oscillation occurs as the wall losses decrease. Increasing the length or resistivity of the lossy section can reduce the feedback of the oscillation to stabilize the amplifier. The W-band harmonic multiplying gyro-TWA is predicted to yield a peak output power of 111 kW at 98 GHz with an efficiency of 25%, a saturated gain of 26 dB, and a bandwidth of 1.6 GHz for a 60 kV, 7.5 A electron beam with an axial velocity spread of 8%.

Micro-pulses generation in ECR breakdown stimulated by gyrotron radiation at 37,5 GHz

International Nuclear Information System (INIS)

Skalyga, V.; Zorin, V.; Izotov, I.; Golubev, S.; Razin, S.; Sidorov, A.; Vodopyanov, A.

2012-01-01

The present work is devoted to experimental and theoretical investigation of the creation of short pulsed (< 100 μs) multicharged ion beams. The possibility of quasi-stationary generation of short pulsed beams under conditions of quasi-gasdynamic plasma confinement was shown in recent experiments. Later another way of such beams creation based on the Pre-glow effect was proposed. In present work it was demonstrated that in the case when duration of microwave (MW) pulse is less than formation time of Pre-glow peak, realization of a regime when ion current is negligible during MW pulse and intense multicharged ions flux appears only when MW ends could be possible. Such pulses after the end of MW were called micro-pulses. In the present work the generation of micro-pulses was observed in experiments with ECR discharge stimulated by gyrotron radiation at 37,5 GHz, 100 kW. In this case pulses with duration less than 30 μs were obtained. Probably the same effect was observed in GANIL where 14 GHz radiation was used and pulses with duration about 2 ms were registered. In present work it was shown that the intensity of such micro-pulse could be higher than intensity of Pre-glow peak at the same conditions but with longer MW pulse. The generation of micro-pulses of nitrogen and argon multicharged ions with current of a few mA and length about 30 μs after MW pulse with duration of 30-100 μs was demonstrated. The low level of impurities, high current density and rather high average charge make possible to consider such micro-pulse regime as a possibility for the creation of a short pulsed ion source. The paper is followed by the slides of the presentation. (authors)

Three-dimensional simulation of triode-type MIG for 1 MW, 120 GHz gyrotron for ECRH applications

Science.gov (United States)

Singh, Udaybir; Kumar, Nitin; Kumar, Narendra; Kumar, Anil; Sinha, A. K.

2012-01-01

In this paper, the three-dimensional simulation of triode-type magnetron injection gun (MIG) for 120 GHz, 1 MW gyrotron is presented. The operating voltages of the modulating anode and the accelerating anode are 57 kV and 80 kV respectively. The high order TE 22,6 mode is selected as the operating mode and the electron beam is launched at the first radial maxima for the fundamental beam-mode operation. The initial design is obtained by using the in-house developed code MIGSYN. The numerical simulation is performed by using the commercially available code CST-Particle Studio (PS). The simulated results of MIG obtained by using CST-PS are validated with other simulation codes EGUN and TRAK, respectively. The results on the design output parameters obtained by using these three codes are found to be in close agreement.

TS gene polymorphisms are not good markers of response to 5-FU therapy in stage III colon cancer patients.

Science.gov (United States)

Fariña-Sarasqueta, A; Gosens, M J E M; Moerland, E; van Lijnschoten, I; Lemmens, V E P P; Slooter, G D; Rutten, H J T; van den Brule, Adriaan J C

2011-08-01

Although the predictive and prognostic value of thymidylate synthase (TS) expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphisms genotyping in therapy response in stage III colon carcinoma patients treated with 5-FU adjuvant chemotherapy. 251 patients diagnosed with stage III colon carcinoma treated with surgery followed by 5-FU based adjuvant therapy were selected. The variable number of tandem repeats (VNTR) and the single nucleotide polymorphism (SNP) in the 5'untranslated region of the TS gene were genotyped. There was a positive association between tumor T stage and the VNTR genotypes (p = 0.05). In both univariate and multivariate survival analysis no effects of the studied polymorphisms on survival were found. However, there was an association between both polymorphisms and age. Among patients younger than 60 years, the patients homozygous for 2R seemed to have a better overall survival, whereas among the patients older than 67 this longer survival was seen by the carriers of other genotypes. We conclude that the TS VNTR and SNP do not predict response to 5-FU therapy in patients with stage III colon carcinoma. However, age appears to modify the effects of TS polymorphisms on survival.

Concurrent chemoradiotherapy with nedaplatin and 5-fluorouracil (5-FU) for locally advanced squamous cell carcinoma of the esophagus

International Nuclear Information System (INIS)

Kubo, Naoshi; Morimoto, Junya; Tanaka, Hiroaki

2009-01-01

Concurrent chemoradiotherapy (CRT) using cisplatin (CDDP) and 5-fluorouracil (5-FU) is the standard treatment for unresectable locally advanced esophageal carcinoma. Although this regimen has been widely accepted in Japan, the adverse effect of CDDP such as gastrointestinal and renal toxicity may sometimes be the cause of interruption of the treatment, especially among the elderly patients. Cis-diammine-glycolatoplatinum (nedaplatin: CDGP) is a new platinum agent, which was developed with the aim of decreasing renal and gastrointestinal toxicities but maintaining the effectiveness of CDDP. We reported the efficacy and safety of CRT using CDGP and 5-FU for locally advanced squamous cell carcinoma of the esophagus. Between January 2001 and December 2007, 65 patients with locally advanced esophageal cancer (39 patients with unresectable tumor (cT4) and 26 patients with distant lymphnode or bulky lymphnode metastasis) were eligible and given informed consent and cared by the Department of Surgical Oncology of Osaka City University. Patients received a continuous infusion of 5-FU (250 mg/body) on days 1-21. CDGP was administered at the dose of 10 mg/body by bolus infusion for 1 hour on days 1-5, 8-12 and 15-19 just before radiotherapy. Radiotherapy was delivered in 1.8 Gy fractions, 5 days/week for 4 weeks. For the effective cases of CRT, a surgical resection was followed subsequently and an additional radiotherapy at the dose of 20 Gy was performed for non-effective cases. Complete or partial response was achieved in 46 patients (71%). Hematologic toxicities such as grades 3 and 4 leucocytopenia developed in 19 patients and thrombocytopenia developed in 20 patients, which were well tolerated by conservative therapy. Gastrointestinal and renal toxicities were developed in only a few patients. There was no CRT-related death. Of all 65 patients, 25 patients underwent a surgical resection while 19 patients could receive a curative resection (R0 operation). In the resected

Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.

Directory of Open Access Journals (Sweden)

Ana de la Cueva

Full Text Available Colorectal cancer (CRC is the third major cause of cancer related deaths in the world. 5-fluorouracil (5-FU is widely used for the treatment of colorectal cancer but as a single-agent renders low response rates. Choline kinase alpha (ChoKα, an enzyme that plays a role in cell proliferation and transformation, has been reported overexpressed in many different tumors, including colorectal tumors. ChoKα inhibitors have recently entered clinical trials as a novel antitumor strategy.ChoKα specific inhibitors, MN58b and TCD-717, have demonstrated a potent antitumoral activity both in vitro and in vivo against several tumor-derived cell line xenografts including CRC-derived cell lines. The effect of ChoKα inhibitors in combination with 5-FU as a new alternative for the treatment of colon tumors has been investigated both in vitro in CRC-tumour derived cell lines, and in vivo in mouse xenografts models. The effects on thymidilate synthase (TS and thymidine kinase (TK1 levels, two enzymes known to play an essential role in the mechanism of action of 5-FU, were analyzed by western blotting and quantitative PCR analysis. The combination of 5-FU with ChoKα inhibitors resulted in a synergistic effect in vitro in three different human colon cancer cell lines, and in vivo against human colon xenografts in nude mice. ChoKα inhibitors modulate the expression levels of TS and TK1 through inhibition of E2F production, providing a rational for its mechanism of action.Our data suggest that both drugs in combination display a synergistic antitumoral effect due to ChoKα inhibitors-driven modulation of the metabolization of 5-FU. The clinical relevance of these findings is strongly supported since TCD-717 has recently entered Phase I clinical trials against solid tumors.

Quantification of the fluorine containing drug 5-fluorouracil in cancer cells by GaF molecular absorption via high-resolution continuum source molecular absorption spectrometry

Science.gov (United States)

Krüger, Magnus; Huang, Mao-Dong; Becker-Roß, Helmut; Florek, Stefan; Ott, Ingo; Gust, Ronald

The development of high-resolution continuum source molecular absorption spectrometry made the quantification of fluorine feasible by measuring the molecular absorption as gallium monofluoride (GaF). Using this new technique, we developed on the example of 5-fluorouracil (5-FU) a graphite furnace method to quantify fluorine in organic molecules. The effect of 5-FU on the generation of the diatomic GaF molecule was investigated. The experimental conditions such as gallium nitrate amount, temperature program, interfering anions (represented as corresponding acids) and calibration for the determination of 5-FU in standard solution and in cellular matrix samples were investigated and optimized. The sample matrix showed no effect on the sensitivity of GaF molecular absorption. A simple calibration curve using an inorganic sodium fluoride solution can conveniently be used for the calibration. The described method is sensitive and the achievable limit of detection is 0.23 ng of 5-FU. In order to establish the concept of "fluorine as a probe in medicinal chemistry" an exemplary application was selected, in which the developed method was successfully demonstrated by performing cellular uptake studies of the 5-FU in human colon carcinoma cells.

Numerical Design of Megawatt Gyrotron with 120 GHz Frequency and 50% Efficiency for Plasma Fusion Application

Science.gov (United States)

Kumar, Nitin; Singh, Udaybir; Kumar, Anil; Bhattacharya, Ranajoy; Singh, T. P.; Sinha, A. K.

2013-02-01

The design of 120 GHz, 1 MW gyrotron for plasma fusion application is presented in this paper. The mode selection is carried out considering the aim of minimum mode competition, minimum cavity wall heating, etc. On the basis of the selected operating mode, the interaction cavity design and beam-wave interaction computation are carried out by using the PIC code. The design of triode type Magnetron Injection Gun (MIG) is also presented. Trajectory code EGUN, synthesis code MIGSYN and data analysis code MIGANS are used in the MIG designing. Further, the design of MIG is also validated by using the another trajectory code TRAK. The design results of beam dumping system (collector) and RF window are also presented. Depressed collector is designed to enhance the overall tube efficiency. The design study confirms >1 MW output power with tube efficiency around 50% (with collector efficiency).

Backscattering of gyrotron radiation and short-wavelength turbulence during electron cyclotron resonance plasma heating in the L-2M stellarator

Energy Technology Data Exchange (ETDEWEB)

Batanov, G. M.; Borzosekov, V. D., E-mail: tinborz@gmail.com; Kovrizhnykh, L. M.; Kolik, L. V.; Konchekov, E. M.; Malakhov, D. V.; Petrov, A. E.; Sarksyan, K. A.; Skvortsova, N. N.; Stepakhin, V. D.; Kharchev, N. K. [Russian Academy of Sciences, Prokhorov General Physics Institute (Russian Federation)

2013-06-15

Backscattering of gyrotron radiation ({theta} = {pi}) by short-wavelength density fluctuations (k{sub Up-Tack} = 30 cm{sup -1}) in the plasma of the L-2M stellarator was studied under conditions of electron cyclotron resonance (ECR) plasma heating at the second harmonic of the electron gyrofrequency (75 GHz). The scattering of the O-wave emerging due to the splitting of the linearly polarized gyrotron radiation into the X- and O-waves was analyzed. The signal obtained after homodyne detection of scattered radiation is a result of interference of the reference signal, the quasi-steady component, and the fast oscillating component. The coefficients of reflection of the quasi-steady component, R{sub =}{sup 2}(Y), and fast oscillating component, R{sub {approx}}{sup 2}(Y), of scattered radiation are estimated. The growth of the R{sub {approx}}{sup 2}(Y) coefficient from 3.7 Multiplication-Sign 10{sup -4} to 5.2 Multiplication-Sign 10{sup -4} with increasing ECR heating power from 190 to 430 kW is found to correlate with the decrease in the energy lifetime from 1.9 to 1.46 ms. The relative density of short-wavelength fluctuations is estimated to be Left-Pointing-Angle-Bracket n{sub {approx}}{sup 2} Right-Pointing-Angle-Bracket / Left-Pointing-Angle-Bracket n{sub e}{sup 2} Right-Pointing-Angle-Bracket = 3 Multiplication-Sign 10{sup -7}. It is shown that the frequencies of short-wavelength fluctuations are in the range 10-150 kHz. The recorded short-wavelength fluctuations can be interpreted as structural turbulence, the energy of which comprises {approx}10% of the total fluctuations energy. Simulations of transport processes show that neoclassical heat fluxes are much smaller than anomalous ones. It is suggested that short-wavelength turbulence plays a decisive role in the anomalous heat transport.

Rabbit Feces as Feed for Ruminants and as an Energy Source

Directory of Open Access Journals (Sweden)

Pier Giorgio Peiretti

2014-12-01

Full Text Available There are prospects for using novel feeds from various sources to provide ruminants with alternative sources of protein and energy such as by-products, and animal wastes. Rabbit feces are a concentrated source of fiber and could have commercial potential both as input biomass in anaerobic processes for biogas production, as well as a fibrous source for ruminal degradation. The aims of this work were to assess the potential as ruminant feeding and as biogas production of rabbit feces, in comparison with 12 crops. The chemical composition and the potential and experimental in vitro true digestibility (IVTD and neutral detergent fiber digestibility (NDFD of 148 feces samples were determined by using chemical methods, Daisy system digestibility and/or NIRS predictions. The average biomethane potential (BMP was 286 ± 10 lCH4/kg SV with −4% vs. the crops average. Milk forage unit (milk FU, IVTD and NDFD of feces were 0.54 ± 0.06 milk FU/kg DM, 74% ± 3% and 50% ± 5%, respectively, with comparisons of −19%, −11% and −24% vs. the crops average. Reconstruction of the potential values based on the chemical constituents but using the crop partial least square model well agreed with the NIRS calibrations and cross-validation. In a global NIRS calibration of the feces and crops the relative predicted deviation for IVTD, NDFD and milk FU were 3.1, 2.9 and 2.6, respectively, and only 1.5 for BMP. Running the Daisy system for rabbit feces in rumen fluid gave some inconsistencies, weakened the functional relationships, and appeared not to be correlated with the potential values of IVTD and NDFD. Nevertheless, the energetic potential of feces appears to be similar to some conventional crops at different degrees of maturity. Thus we conclude that rabbit feces has potential value as a ruminant feed and for biogas production.

Kung Fu a jeho zařazení do výuky úpolů ve školní tělesné výchově

OpenAIRE

Krbcová, Pavlína

2015-01-01

The goal of this thesis is to analyse kung fu from the pespective of teaching Combatives in Physicial Education courses, suggest model exercises with the help of the consultants named in the theoretical part and create model lessons that teachers may use in their Physical Education courses. The teoretical part focuses on history, taxonomy and teaching of Combatives in Physical Education courses. In addition, in describes history, characteristics and taxonomy of kung fu. The experimental part ...

Difference in effect of single immunosuppressive agents (cyclophosphamide, CCNU, 5-FU) on peripheral blood immune cell parameters and central nervous system immunoglobulin synthesis rate in patients with multiple sclerosis.

Science.gov (United States)

Shih, W W; Baumhefner, R W; Tourtellotte, W W; Haskell, C M; Korn, E L; Fahey, J L

1983-01-01

Cyclophosphamide (CY), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 5-fluorouracil (5-FU) were given in single course schedules to chronic progressive multiple sclerosis (MS) patients clinically stable for 6 months. The following peripheral immune cellular parameters were measured before, during and after each drug administration: white blood count (WBC), polymorphonuclear count (PMN), lymphocyte count, percentage of T cells, T cell response to phytohaemagglutinin (PHA), percentage of B cells, percentage of cells bearing receptors for the Fc portion of immunoglobulin (% FcR cells), killer (K) cell activity defined by antibody-dependent cellular cytotoxicity (ADCC), and natural killer (NK) cell activity. Central nervous system (CNS) immunoglobulin G (IgG) synthesis was also measured. The patients were followed carefully by both quantitative and qualitative methods for any change in their neurologic condition. Selective reduction in NK activity was observed with CY and 5-FU while no significant alteration was seen in %FcR cells and K activity. CY differed from 5-FU in reducing lymphocyte count and B cell percentage while 5-FU decreased the percentage of T cells. CCNU, but not the other drugs, reduced T cell proliferative response to PHA. In addition, CCNU, which is known to penetrate well into the nervous system, caused a modest reduction in CNS IgG synthesis, while 5-FU had an uncertain effect. Clinically the patients were unchanged or continued to progress in their disability. The results suggest an independence of the CNS immune from the systemic immune system in MS in response to many immunosuppressive drugs. PMID:6603303

Neoadjuvant 5-FU or Capecitabine Plus Radiation With or Without Oxaliplatin in Rectal Cancer Patients: A Phase III Randomized Clinical Trial

Science.gov (United States)

Yothers, Greg; O’Connell, Michael J.; Beart, Robert W.; Wozniak, Timothy F.; Pitot, Henry C.; Shields, Anthony F.; Landry, Jerome C.; Ryan, David P.; Arora, Amit; Evans, Lisa S.; Bahary, Nathan; Soori, Gamini; Eakle, Janice F.; Robertson, John M.; Moore, Dennis F.; Mullane, Michael R.; Marchello, Benjamin T.; Ward, Patrick J.; Sharif, Saima; Roh, Mark S.; Wolmark, Norman

2015-01-01

Background: National Surgical Adjuvant Breast and Bowel Project R-04 was designed to determine whether the oral fluoropyrimidine capecitabine could be substituted for continuous infusion 5-FU in the curative setting of stage II/III rectal cancer during neoadjuvant radiation therapy and whether the addition of oxaliplatin could further enhance the activity of fluoropyrimidine-sensitized radiation. Methods: Patients with clinical stage II or III rectal cancer undergoing preoperative radiation were randomly assigned to one of four chemotherapy regimens in a 2x2 design: CVI 5-FU or oral capecitabine with or without oxaliplatin. The primary endpoint was local-regional tumor control. Time-to-event endpoint distributions were estimated using the Kaplan-Meier method. Hazard ratios were estimated from Cox proportional hazard models. All statistical tests were two-sided. Results: Among 1608 randomized patients there were no statistically significant differences between regimens using 5-FU vs capecitabine in three-year local-regional tumor event rates (11.2% vs 11.8%), 5-year DFS (66.4% vs 67.7%), or 5-year OS (79.9% vs 80.8%); or for oxaliplatin vs no oxaliplatin for the three endpoints of local-regional events, DFS, and OS (11.2% vs 12.1%, 69.2% vs 64.2%, and 81.3% vs 79.0%). The addition of oxaliplatin was associated with statistically significantly more overall and grade 3–4 diarrhea (P < .0001). Three-year rates of local-regional recurrence among patients who underwent R0 resection ranged from 3.1 to 5.1% depending on the study arm. Conclusions: Continuous infusion 5-FU produced outcomes for local-regional control, DFS, and OS similar to those obtained with oral capecitabine combined with radiation. This study establishes capecitabine as a standard of care in the pre-operative rectal setting. Oxaliplatin did not improve the local-regional failure rate, DFS, or OS for any patient risk group but did add considerable toxicity. PMID:26374429

New concepts in microwave sources for e-e+ supercolliders

International Nuclear Information System (INIS)

Granatstein, V.L.; McAdoo, J.H.; Striffler, C.D.; Lawson, W.; Latham, P.E.; Reiser, M.

1986-01-01

The realization of e - e + supercolliders will require advances in tehnology including the development of x-band microwave amplifiers with pulse energy > 60 J. Candidate microwave amplifiers include klystrons, lasertrons, free electron lasers (FEL's), and gyrotrons; gyrotron amplifiers employing a multicavity gyroklystron configuration appear advantageous at λ ≅ 3 cm. Measurements on a 50 kW, 1 μs gyroklystron show phase jitter 0 indicating compatibility of this type of amplifier with collider requirements. The University of Maryland is currently developing an x-band, TE 0 01 mode gyroklystron driven by 500 keV, 160 A, 2 μs electron beam pulses; combining this tube with a TE 0 01 binary pulse compression circuit under development at SLAC could produce 475 MW, 120 ns microwave pulses which imply the feasibility of achieving linac accelerating fields in the range 100-200 MV/m

How Can Asian Snack FuLoi Plan Successful Entering to Greater Helsinki Area? : Market research

OpenAIRE

Nguyen, Loc

2014-01-01

This thesis introduces the significant factors of market research and its importance when considering doing international business. Furthermore, it could be useful for investors who have same favour to enter Finnish market. The case company is Asian Snack FuLoi- a German food industry company looking for new market. The goal of this study was to investigate the possibility for a company to enter Finland in general and Greater Helsinki in particular. The thesis was structured with theor...

VARIABILITY AT THE EDGE: OPTICAL NEAR/IR RAPID-CADENCE MONITORING OF NEWLY OUTBURSTING FU ORIONIS OBJECT HBC 722

International Nuclear Information System (INIS)

Green, Joel D.; Robertson, Paul; Pak, Soojong; Meschiari, Stefano; Baek, Giseon; Lee, Jeong-Eun; Pooley, David; Im, Myungshin; Jeon, Yiseul; Choi, Changsu

2013-01-01

We present the detection of day-timescale periodic variability in the r-band lightcurve of newly outbursting FU Orionis-type object HBC 722, taken from >42 nights of observation with the CQUEAN instrument on the McDonald Observatory 2.1 m telescope. The optical/near-IR lightcurve of HBC 722 shows a complex array of periodic variability, clustering around 5.8-day (0.044 mag amplitude) and 1.28-day (0.016 mag amplitude) periods, after removal of overall baseline variation. We attribute the unusual number of comparable strength signals to a phenomenon related to the temporary increase in accretion rate associated with FUors. We consider semi-random 'flickering', magnetic braking/field compression and rotational asymmetries in the disk instability region as potential sources of variability. Assuming that the 5.8-day period is due to stellar rotation and the 1.28-day period is indicative of Keplerian rotation at the inner radius of the accretion disk (at 2 R * ), we derive a B-field strength of 2.2-2.7 kG, slightly larger than typical T Tauri stars. If instead the 5.8-day signal is from a disk asymmetry, the instability region has an outer radius of 5.4 R * , consistent with models of FUor disks. Further exploration of the time domain in this complicated source and related objects will be key to understanding accretion processes.

A catalog of pre-main-sequence emission-line stars with IRAS source associations

International Nuclear Information System (INIS)

Weintraub, D.A.

1990-01-01

To aid in finding premain-sequence (PMS) emission-line stars that might have dusty circumstellar environments, 361 PMS stars that are associated with 304 separate IRAS sources were identified. These stars include 200 classical T Tauri stars, 25 weak-lined (naked) T Tauri stars, 56 Herbig Ae/Be stars, six FU Orionis stars, and two SU Aurigae stars. All six of the FU Orionis stars surveyed by IRAS were detected. Of the PMS-IRAS Point Source Catalog (PSC) associations, 90 are new and are not noted in the PSC. The other 271 entries include 104 that are correctly identified in the PSC but have not yet appeared in the literature, 56 more that can be found in both the PSC and in the published and unpublished iterature, and 111 that are in the literature but not in the PSC. Spectral slope diagrams constructed from the 12-, 25-, and 60-micron flux densities reveal unique distributions for the different PMS subclasses; these diagrams may help identify the best candidate PMS stars for observations of circumstellar dust. 30 refs

Investigation on biochemical compositional changes during the microbial fermentation process of Fu brick tea by LC-MS based metabolomics.

Science.gov (United States)

Xu, Jie; Hu, Feng-Lin; Wang, Wei; Wan, Xiao-Chun; Bao, Guan-Hu

2015-11-01

Fu brick tea (FBT) is a unique post-fermented tea product which is fermented with fungi during the manufacturing process. In this study, we investigated the biochemical compositional changes occurring during the microbial fermentation process (MFP) of FBT based on non-targeted LC-MS, which was a comprehensive and unbiased methodology. Our data analysis took a two-phase approach: (1) comparison of FBT with other tea products using PCA analysis to exhibit the characteristic effect of MFP on the formation of Fu brick tea and (2) comparison of tea samples throughout the MFP of FBT to elucidate the possible key metabolic pathways produced by the fungi. Non-targeted LC-MS analysis clearly distinguished FBT with other tea samples and highlighted some interesting metabolic pathways during the MFP including B ring fission catechin. Our study demonstrated that those fungi had a significant influence on the biochemical profiles in the FBT and consequently contributed to its unique quality. Copyright © 2014 Elsevier Ltd. All rights reserved.

Evaluation of RRTMG and Fu-Liou RTM Performance against LBLRTM-DISORT Simulations and CERES Data in terms of Ice Clouds Radiative Effects

Science.gov (United States)

Gu, B.; Yang, P.; Kuo, C. P.; Mlawer, E. J.

2017-12-01

Evaluation of RRTMG and Fu-Liou RTM Performance against LBLRTM-DISORT Simulations and CERES Data in terms of Ice Clouds Radiative Effects Boyan Gu1, Ping Yang1, Chia-Pang Kuo1, Eli J. Mlawer2 Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA Atmospheric and Environmental Research (AER), Lexington, MA 02421, USA Ice clouds play an important role in climate system, especially in the Earth's radiation balance and hydrological cycle. However, the representation of ice cloud radiative effects (CRE) remains significant uncertainty, because scattering properties of ice clouds are not well considered in general circulation models (GCM). We analyze the strengths and weakness of the Rapid Radiative Transfer Model for GCM Applications (RRTMG) and Fu-Liou Radiative Transfer Model (RTM) against rigorous LBLRTM-DISORT (a combination of Line-By-Line Radiative Transfer Model and Discrete Ordinate Radiative Transfer Model) calculations and CERES (Clouds and the Earth's Radiant Energy System) flux observations. In total, 6 US standard atmospheric profiles and 42 atmospheric profiles from Atmospheric and Environmental Research (AER) Company are used to evaluate the RRTMG and Fu-Liou RTM by LBLRTM-DISORT calculations from 0 to 3250 cm-1. Ice cloud radiative effect simulations with RRTMG and Fu-Liou RTM are initialized using the ice cloud properties from MODIS collection-6 products. Simulations of single layer ice cloud CRE by RRTMG and LBLRTM-DISORT show that RRTMG, neglecting scattering, overestimates the TOA flux by about 0-15 W/m2 depending on the cloud particle size and optical depth, and the most significant overestimation occurs when the particle effective radius is small (around 10 μm) and the cloud optical depth is intermediate (about 1-10). The overestimation reduces significantly when the similarity rule is applied to RRTMG. We combine ice cloud properties from MODIS Collection-6 and atmospheric profiles from the Modern

Millimeter wave technology IV and radio frequency power sources; Proceedings of the Meeting, Orlando, FL, May 21, 22, 1987

International Nuclear Information System (INIS)

Wiltse, J.C.; Coleman, J.T.

1987-01-01

The present conference on mm-wave technology and radio-frequency power sources discusses topics in the fields of vacuum devices, mm-wave antennas and transmission lines, mm-wave systems and subsystems, and mm-wave techniques and components. Attention is given to recent experiments with planar orotrons, a high peak power X-band gyroklystron for linear supercolliders, cathode-driven crossed-field amplifiers, multi-MW quasi-optical gyrotrons, the radiation coupling of interinjection-locked oscillators, air-to-air mm-wave communications, mm-wave active and passive sensors for terrain mapping, and mm-wave components for electronically controllable antennas

60 GHz gyrotron development program. Final report, April 1979-June 1984

International Nuclear Information System (INIS)

Shively, J.F.; Bier, R.E.; Caplan, M.

1986-01-01

The original objective of this program was to develop a microwave amplifier or oscillator capable of producing 200 kW CW power output at 110 GHz. The use of cyclotron resonance interaction was pursued, and the design phases of this effort are discussed. Later, however, the program's objective was changed to develop a family of oscillators capable of producing 200 kw of peak output power at 60 GHz. Gyrotron behavior studies were performed at 28 GHz to obtain generic design information as quickly as possible. The first experimental device at 60 GHz produced over 200 kw of peak power at a pulse duration of 20 μs. Heating problems and mode interference were encountered. The second experimental tube incorporated an optimized gun location but also suffered from mode interference. The third experimental tube included modifications that reduced mode interference. It demonstrated 200 kw of peak output at 100 ms pulse duration. The fourth experimental tube, which used an older rf circuit design but in a CW configuration, produced 71.5 kW CW. The fifth experimental tube incorporated a thinner double-disc output window which improved window bandwidth and reduced window loss. This tube also incorporated modifications to the drift tunnel and cavity coupling, which had proven successful in the third experimental pulse tube tests. It produced 123 kW of CW output power at 60 GHz rf load coolant boiling and tube window failure terminated the tests. A new waterload was designed and constructed, and alternative window designs were explored

Mechanisms of amplification of ultrashort electromagnetic pulses in gyrotron traveling wave tube with helically corrugated waveguide

International Nuclear Information System (INIS)

Ginzburg, N. S.; Zaslavsky, V. Yu.; Zotova, I. V.; Sergeev, A. S.; Zheleznov, I. V.; Samsonov, S. V.; Mishakin, S. V.

2015-01-01

A time-domain self consistent theory of a gyrotron traveling wave tube with a helically corrugated operating waveguide has been developed. Based on this model, the process of short pulse amplification was studied in regimes of grazing and intersection of the dispersion curves of the electromagnetic wave and the electron beam. In the first case, the possibility of amplification without pulse form distortion was demonstrated for the pulse spectrum width of the order of the gain bandwidth. In the second case, when the electrons' axial velocity was smaller than the wave's group velocity, it was shown that the slippage of the incident signal with respect to the electron beam provides feeding of the signal by “fresh” electrons without initial modulation. As a result, the amplitude of the output pulse can exceed the amplitude of its saturated value for the case of the grazing regime, and, for optimal parameters, the peak output power can be even larger than the kinetic power of the electron beam

Title of paper: the induction of P-53 independent programmed cell death (apoptosis) with ionizing radiation and 5-fluorouracil (5-FU) in the HT-29 human colon carcinoma cell line

International Nuclear Information System (INIS)

Blackstock, A. Wm.; Gill, Misha; Hess, Suzanne M.; Fisher, Robert W.; Leadon, Steven A.; Tepper, Joel E.

1996-01-01

Purpose/Objective: The role of programmed cell death (apoptosis) as a cellular response to cancer therapy such as radiation or chemotherapy is the subject of much study, and manipulation of the apoptotic response in tumor cells may be valuable in the treatment of a variety of cancers. Both p53 dependent and independent apoptotic pathways have been identified; p53 is mutated in at least 50 % of human cancers and a majority of radiation resistant tumors contain p53 mutations. This study is designed to examine the induction of programmed cell death in a human colon carcinoma cell line that possesses two mutated p53 alleles. Ionizing radiation alone, or in combination with the chemotherapeutic drug 5-fluorouracil (5-FU), were used to elicit the apoptotic response. This study will focus on whether these treatments can induce a significant apoptotic response in cells that have mutated p53 alleles. Materials and Methods: HT-29 cells were assessed for clonogenic survival after being plated at a variety of densities, and treated with single graded doses of radiation (0, 1, 2, 4, 6, 8, 10 Gy) either alone or immediately prior to a 24 hour exposure to 5-FU (2 ug/ml). The extent of radiation and 5-FU-induced apoptosis was determined in the HT-29 cell line after single doses of 0, 2, 5, and 10 Gy either alone or immediately prior to a 24 hour incubation in 5-FU (2 ug/ml). Three separate assays were used to evaluate the apoptotic response. Cells undergoing apoptosis undergo gross morphological changes including a condensation of chromatin, membrane blebbing, and an eventual release of membrane bound cytoplasmic fragments. Hematoxylin and eosin staining were used to visualize some of these morphological changes. Another characteristic of the apoptotic response is the activation of an endonuclease that cleaves DNA into specific fragments. Accordingly, an ELISA cell death assay (Boehringer Mannheim, Indianapolis IN) was used to quantitate cytoplasmic histone-associated DNA

Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol.

Science.gov (United States)

Mokhtari, Fatemeh; Bostakian, Anis; Shahmoradi, Zabihollah; Jafari-Koshki, Tohid; Iraji, Fariba; Faghihi, Gita; Hosseini, Sayed Mohsen; Bafandeh, Behzad

2018-04-01

Vitiligo is a pigmentary disorder of skin affecting at least 1% of the world population of all races in both sexes. Its importance is mainly due to subsequent social and psychological problems rather than clinical complications. Various treatment choices are available for vitiligo; however, laser-based courses have shown to give more acceptable results. The aim of this trial was to evaluate the efficacy of Er:YAG laser as a supplementary medicine to topical 5FU and clobetasol in vitiligo patients. Two comparable vitiligo patches from 38 eligible patients were randomized to receive topical 5FU and clobetasol in control group and additional Er:YAG laser in intervention group. Major outcomes of interest were the size of patch and pigmentation score at randomization and 2 and 4 months after therapy. Final sample included 18 (47%) male patients and age of 35.66±8.04. The performance Er:YAG group was superior in all sites. Reduction in the size of patches was greater in Er:YAG group (p-value=.004). Also, this group showed a higher pigmentation scores in the trial period than control group (p-value<.001). Greater reduction in the size and increase in pigmentation score was seen in Er:YAG group especially for short periods after therapy and repeating laser sessions may help improving final outcomes. Er:AYG could help in reducing complications of long-term topical treatments, achieving faster response, and improving patient adherence. © 2017 Wiley Periodicals, Inc.

A prospective evaluation of treatment with Selective Internal Radiation Therapy (SIR-spheres) in patients with unresectable liver metastases from colorectal cancer previously treated with 5-FU based chemotherapy

International Nuclear Information System (INIS)

Lim, L; Gibbs, P; Yip, D; Shapiro, JD; Dowling, R; Smith, D; Little, A; Bailey, W; Liechtenstein, M

2005-01-01

To prospectively evaluate the efficacy and safety of selective internal radiation (SIR) spheres in patients with inoperable liver metastases from colorectal cancer who have failed 5FU based chemotherapy. Patients were prospectively enrolled at three Australian centres. All patients had previously received 5-FU based chemotherapy for metastatic colorectal cancer. Patients were ECOG 0–2 and had liver dominant or liver only disease. Concurrent 5-FU was given at investigator discretion. Thirty patients were treated between January 2002 and March 2004. As of July 2004 the median follow-up is 18.3 months. Median patient age was 61.7 years (range 36 – 77). Twenty-nine patients are evaluable for toxicity and response. There were 10 partial responses (33%), with the median duration of response being 8.3 months (range 2–18) and median time to progression of 5.3 mths. Response rates were lower (21%) and progression free survival shorter (3.9 mths) in patients that had received all standard chemotherapy options (n = 14). No responses were seen in patients with a poor performance status (n = 3) or extrahepatic disease (n = 6). Overall treatment related toxicity was acceptable, however significant late toxicity included 4 cases of gastric ulceration. In patients with metastatic colorectal cancer that have previously received treatment with 5-FU based chemotherapy, treatment with SIR-spheres has demonstrated encouraging activity. Further studies are required to better define the subsets of patients most likely to respond

Stabilization of the potential multi-steady-state absolute instabilities in a gyrotron traveling-wave amplifier

International Nuclear Information System (INIS)

Du Chaohai; Liu Pukun

2009-01-01

The problem of spurious oscillations induced by absolute instabilities is the most challenging one that hinders the development of the millimeter-wave gyrotron traveling-wave amplifiers (gyro-TWTs). A spurious oscillation exists as a high order axial mode (HOAM) in the interaction circuit. This paper is devoted to demonstrating the complicated steady states of these HOAMs and exploring corresponding techniques to stabilize these potential multi-steady-state absolute instabilities. The stability-oriented design principle is conveyed in a start-to-end design flow of a Ka-band TE 11 mode gyro-TWT. Strong magnetic tapering near the downstream port, which is capable of cutting short the effective interaction circuit of a spurious oscillation and simultaneously boosting the amplification performance, is for the first time proposed to further improve the system stability. It is also found that an ideal prebunched electron beam in the linear stage is the necessary condition to efficient amplification in the nonlinear stage, suggesting that it is feasible to design a stable prebunching stage to replace the distributed-loss-loaded linear stage. The stability-oriented design principle provides more explicit reference for future design of a zero-drive stable gyro-TWT.

Quantification of the fluorine containing drug 5-fluorouracil in cancer cells by GaF molecular absorption via high-resolution continuum source molecular absorption spectrometry

International Nuclear Information System (INIS)

Krüger, Magnus; Huang, Mao-Dong; Becker-Roß, Helmut; Florek, Stefan; Ott, Ingo; Gust, Ronald

2012-01-01

The development of high-resolution continuum source molecular absorption spectrometry made the quantification of fluorine feasible by measuring the molecular absorption as gallium monofluoride (GaF). Using this new technique, we developed on the example of 5-fluorouracil (5-FU) a graphite furnace method to quantify fluorine in organic molecules. The effect of 5-FU on the generation of the diatomic GaF molecule was investigated. The experimental conditions such as gallium nitrate amount, temperature program, interfering anions (represented as corresponding acids) and calibration for the determination of 5-FU in standard solution and in cellular matrix samples were investigated and optimized. The sample matrix showed no effect on the sensitivity of GaF molecular absorption. A simple calibration curve using an inorganic sodium fluoride solution can conveniently be used for the calibration. The described method is sensitive and the achievable limit of detection is 0.23 ng of 5-FU. In order to establish the concept of “fluorine as a probe in medicinal chemistry” an exemplary application was selected, in which the developed method was successfully demonstrated by performing cellular uptake studies of the 5-FU in human colon carcinoma cells. - Highlights: ► Development of HR-CS MAS for quantification of fluorine bound to organic molecules ► Measuring as molecular absorption of gallium monofluoride ► Quantification of organic-bound fluorine in biological material ► The concept of “fluorine as a probe in medicinal chemistry” could be established

Die Osteonekrose des Fußes: Eine Übersicht

Directory of Open Access Journals (Sweden)

Schenk S

2007-01-01

Full Text Available Die Osteonekrose (ON am Fuß ist eine heterogene Gruppe von Krankheitsbildern, die sich deutlich hinsichtlich Klinik, Verlauf, Prädilektionsalter und Prognose unterscheiden. Ebenso sind die Ursachen für diese Erkrankungen vielfältig: Neben idiopathischen finden sich auch posttraumatische und postoperative Formen. Seltene Ursachen sind Kollagenosen, Stoffwechselerkrankungen wie Diabetes mellitus und Kortikoidtherapie. ON finden sich gehäuft nach Nierentransplantationen. Je nach Ursache tritt eine ON gehäuft in typischer Lokalisation auf. Idiopathische Formen findet man am Os naviculare pedis – Morbus Köhler 1 (MK1, an den Metatarsaleköpfchen – Morbus Köhler 2, "Freiberg’s disease" (MK2, an den Sesambeinen und an der Apophyse des Calcaneus. Operationsbedingte Fälle sind gehäuft am Metatarsaleköpfchen 1 nach Versorgung eines Hallux valgus lokalisiert, posttraumatische Nekrosen am Talus. In diesem Artikel werden die idiopathischen Formen hinsichtlich Klinik und Therapie näher beleuchtet. Bezüglich der Therapie gibt es konservative und operative Ansätze. Die wissenschaftlichen Daten zur Behandlung von idiopathischen Nekrosen sind spärlich, die Behandlungsstrategien jedoch einheitlich und allgemein anerkannt.

A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer

DEFF Research Database (Denmark)

Glimelius, B; Sørbye, H; Balteskard, L

2008-01-01

not differ (4% versus 6%, P = 0.3). Grade 3/4 neutropenia (11% versus 5%, P = 0.01) and grade 2 alopecia (18% versus 9%, P = 0.002) were more common in the FLIRI group. The 60-day mortality was 2.4% versus 2.1%. CONCLUSIONS: Irinotecan with the bolus Nordic schedule (FLIRI) is a convenient treatment with PFS...... and OS comparable to irinotecan with the Lv5FU2 schedule. Neutropenia and alopecia are more prevalent, but both regimens are equally well tolerated....

A inserção do kung fu no Brasil na perspectiva dos mestres pioneiros

OpenAIRE

Ferreira, Fernando Dandoro Castilho

2013-01-01

Resumo: Discutir atualmente a China e sua cultura parece algo bastante útil, principalmente em decorrência da sua posição econômica, que exerce uma impactante influência mundial. Para buscar trazer alguma luz sobre a China, fizemos uso de um marcante e elucidativo elemento de sua cultura, a sua arte marcial. Mais ainda, buscamos avançar neste processo tratando não do Kung Fu em seu berço de origem, mas sim, olhando-o em sua vertente contemporânea, oriunda do processo de disseminação deste em ...

[A case of advanced gastric cancer with carcinomatosa peritonitis effectively treated by 5-FU and low-dose CDDP therapy].

Science.gov (United States)

Saito, E; Kunii, Y; Wada, G; Tsuchiya, S; Yamasaki, T; Sakakibara, N

1997-07-01

A 66-year-old woman was admitted to our clinic for appetite loss and abdominal distension in August 1995. Endoscopic study revealed an advanced gastric cancer in the upper body of her stomach. Abdominal CT study revealed massive ascites and para-aortic lymph nodal involvement. Cytological study of the ascites revealed class V. She was diagnosed to be in the terminal stage of gastric cancer with carcinomatosa peritonitis. Combination chemotherapy with 5-fluorouracil (5-FU) and low-dose cisplatin (CDDP) was given by continuous intravenous injection of 5-FU 500 mg/day, and intermittent intravenous injection of CDDP 30 mg/week was performed for reduction of the ascites and her complaint. Endoscopic study 6 weeks after starting chemotherapy could not find crater of the gastric cancer but only a shallow ulcerative lesion. The biopsy specimen of that lesion was group III. No ascites and over 50% reduction of the para-aortic lymph node were found by the abdominal CT study. This state persisted over 4 weeks. No myelo-suppression, renal dysfunction or any severe side effect were observed during chemotherapy. Her performance status improved from 3 to 1.

Alternative therapy using CDDP/5FU and radiotherapy for nasopharyngeal cancer

International Nuclear Information System (INIS)

Shikama, Naoto; Shikano, Masato; Toita, Takafumi; Yuda, Atsushi; Hayashi, Yasuyuki

2004-01-01

We conducted a prospective study of an alternative chemoradiation protocol comprising cisplatin (CDDP) (50 mg/m 2 /day, 2 days), 5FU (800 mg/m 2 /day, 5 days) and radiotherapy (66 Gy in 36 fractions) for locally advanced nasopharyngeal cancer (stage II-IV). We treated 67 patients (stage II-III:41 patients, IV:26) using this protocol. Fifty-seven patients (85%) received the full-course, three-cycle chemotherapy. Three-year overall survival rate of all patients was 90.5%, and 3-year disease-free survival rate was 78.3%. The recurrent sites were the primary site in four patients, neck lymph node in two and distant metastasis in eight. Severe myelosuppression (grade 3-4) was observed in half of the patients, and severe mucositis (grade 3-4) in about 30%. Chemotherapy induced severe dysfunction of liver or kidney (grade 3-4) was seen in three patients. This treatment strategy may be very useful, but careful medical management is essential. (author)

[XI Hong, XI Hong acupuncture school of thought and Xi Hong Fu].

Science.gov (United States)

Xu, Chun-Juan; Chen, Rong; Yang, Yong-Shou

2008-11-01

XI Hong, a famous acupuncturist in the Southern Song Dynasty, has an important influence and status in history of Chinese acupuncture and moxibustion. After he moved to Linchuan, Jiangxi province, his descendants passed acupuncture from generation to generation. According to records, it was passed to 12 generations. After the tenth generation, it was also passed to apprentices besides descendants, such as accomplished acupuncturists CHEN Hong-gang, LIU Jin and others, forming XI Hong acupuncture school of thought. The poem of acupuncture and moxibustion XI Hong Fu is the representative work about XI Hong academic thought, which was additionally compiled or written by XI Hong's apprentices according to XI Hong academic thought. The poems are of characteristics in acupuncture application and association of acupoints. The academic thought and therapeutic methods of acupuncture in the poems still are widely used in modern clinical acupuncture practice.

Quantification of the fluorine containing drug 5-fluorouracil in cancer cells by GaF molecular absorption via high-resolution continuum source molecular absorption spectrometry

Energy Technology Data Exchange (ETDEWEB)

Krueger, Magnus [Freie Universitaet Berlin, Institut fuer Pharmazie, Pharmazeutische Chemie, Koenigin-Luise-Str. 2-4, 14195 Berlin (Germany); Huang, Mao-Dong; Becker-Ross, Helmut; Florek, Stefan [Leibniz Institut fuer Analytische Wissenschaften, ISAS-e.V., Department Berlin, Albert-Einstein-Str. 9, 12489 Berlin (Germany); Ott, Ingo [Technische Universitaet Carolo Wilhelmina zu Braunschweig, Institut fuer Medizinische und Pharmazeutische Chemie, Beethovenstr. 55, 38106 Braunschweig (Germany); Gust, Ronald, E-mail: ronald.gust@uibk.ac.at [Universitaet Innsbruck, Institut fuer Pharmazie, Pharmazeutische Chemie, Innrain 80/82, 6020 Innsbruck (Austria)

2012-03-15

The development of high-resolution continuum source molecular absorption spectrometry made the quantification of fluorine feasible by measuring the molecular absorption as gallium monofluoride (GaF). Using this new technique, we developed on the example of 5-fluorouracil (5-FU) a graphite furnace method to quantify fluorine in organic molecules. The effect of 5-FU on the generation of the diatomic GaF molecule was investigated. The experimental conditions such as gallium nitrate amount, temperature program, interfering anions (represented as corresponding acids) and calibration for the determination of 5-FU in standard solution and in cellular matrix samples were investigated and optimized. The sample matrix showed no effect on the sensitivity of GaF molecular absorption. A simple calibration curve using an inorganic sodium fluoride solution can conveniently be used for the calibration. The described method is sensitive and the achievable limit of detection is 0.23 ng of 5-FU. In order to establish the concept of 'fluorine as a probe in medicinal chemistry' an exemplary application was selected, in which the developed method was successfully demonstrated by performing cellular uptake studies of the 5-FU in human colon carcinoma cells. - Highlights: Black-Right-Pointing-Pointer Development of HR-CS MAS for quantification of fluorine bound to organic molecules Black-Right-Pointing-Pointer Measuring as molecular absorption of gallium monofluoride Black-Right-Pointing-Pointer Quantification of organic-bound fluorine in biological material Black-Right-Pointing-Pointer The concept of 'fluorine as a probe in medicinal chemistry' could be established.

The dose-volume relationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer

International Nuclear Information System (INIS)

Baglan, Kathy L.; Frazier, Robert C.; Yan Di; Huang, Raywin R.; Martinez, Alvaro A.; Robertson, John M.

2002-01-01

Purpose: A direct relationship between the volume of small bowel irradiated and the degree of acute small bowel toxicity experienced during concurrent 5-fluorouracil (5-FU)-based chemoradiotherapy for rectal carcinoma is well recognized but poorly quantified. This study uses three-dimensional treatment-planning tools to more precisely quantify this dose-volume relationship. Methods and Materials: Forty patients receiving concurrent 5-FU-based chemotherapy and pelvic irradiation for rectal carcinoma had treatment-planning CT scans with small bowel contrast. A median isocentric dose of 50.4 Gy was delivered using a posterior-anterior and opposed lateral field arrangement. Bowel exclusion techniques were routinely used, including prone treatment position on a vacuum bag cradle to allow anterior displacement of the abdominal contents and bladder distension. Individual loops of small bowel were contoured on each slice of the planning CT scan, and a small bowel dose-volume histogram was generated for the initial pelvis field receiving 45 Gy. The volume of small bowel receiving each dose between 5 and 40 Gy was recorded at 5-Gy intervals. Results: Ten patients (25%) experienced Common Toxicity Criteria Grade 3+ acute small bowel toxicity. A highly statistically significant association between the development of Grade 3+ acute small bowel toxicity and the volume of small bowel irradiated was found at each dose level. Specific dose-volume threshold levels were found, below which no Grade 3+ toxicity occurred and above which 50-60% of patients developed Grade 3+ toxicity. The volume of small bowel receiving at least 15 Gy (V 15 ) was strongly associated with the degree of toxicity. Univariate analysis of patient and treatment-related factors revealed no other significant predictors of severe toxicity. Conclusions: A strong dose-volume relationship exists for the development of Grade 3+ acute small bowel toxicity in patients receiving concurrent 5-FU-based chemoradiotherapy

From specific training to global shift of manual preference in Kung Fu experts.

Science.gov (United States)

Maeda, Rodrigo S; Souza, Rosana M; Teixeira, Luis A

2014-02-01

Manual preference and intermanual performance asymmetry have been approached from a multidimensional and dynamic perspective. A point of interest from that approach is the role of lateralized motor experiences on handedness. In this study, intermanual performance asymmetry in sport-specific movements and manual preference in daily living tasks were compared between Kung Fu athletes and novices. Analysis of movement time in the performance of interlaterally symmetric and asymmetric movement patterns showed smaller intermanual performance asymmetry in experts. Analysis of manual preference using the Edinburgh Handedness Inventory indicated that experts presented predominantly weak or moderate strength of right hand preference. Novices, conversely, were found to have predominantly strong right hand preference. These results suggest that extensive bimanual training by experts leads to a global shift of manual preference, affecting hand selection in distinct tasks.

Clinical evaluation of adjuvant chemoradiotherapy with CDDP, 5-Fu, and VP-16 for advanced esophageal cancer

Energy Technology Data Exchange (ETDEWEB)

Mukaida, Hidenori; Hirai, Toshihiro; Yamashita, Yoshinori; Yoshida, Kazuhiro; Hihara, Jun; Kuwahara, Masaki; Inoue, Hideki; Toge, Tetsuya [Hiroshima Univ. (Japan). Research Inst. for Radiation Biology and Medicine

1998-01-01

The aim of this study was to evaluate the efficacy of adjuvant chemoradiotherapy following surgery in patients with advanced esophageal cancer. We followed the cases of 57 such patients treated at our hospital, involving 19 who received adjuvant chemoradiotherapy (CR group), 19 who received radiotherapy alone (R group), and 19 who did received neither (N group). In the CR group, chemotherapy, consisting of cis-diaminodichloroplatinum (CDDP), 5-fluorouracil (5-FU), and etoposide (VP-16), was combined with radiotherapy was administered from 4 weeks after surgery. Concurrent radiotherapy was started at 3 weeks after esophagectomy. CDDP at 50 mg/m{sup 2} was administered on days 1 and 7.5-FU at 500 mg/m{sup 2} and VP-16 at 60 mg/m{sup 2} were administered on days 3, 4, and 5. Thirteen patients (68.4%) were treated with more than 2 cycles of chemotherapy combined with radiation. Side-effects of severe anorexia (grade 3) and leukocytopenia (<1900/{mu}l) were observed in 47% and 39% of the patients, respectively. However no treatment-related death was observed. The 5-year-survival rate was 25.2%, 18.9%, and 15.8%, in the CR group, R group, and N group, respectively. The recurrence rate was 66.7% in the CR group, which was higher than in the matched control groups (46.2% in the N group and 54.5% in the R group), but with no significant difference. These results suggested that adjuvant chemoradiotherapy did not contribute to improvement in prognosis for these patients with advanced esophageal cancer. (author)

Clinical evaluation of adjuvant chemoradiotherapy with CDDP, 5-Fu, and VP-16 for advanced esophageal cancer

International Nuclear Information System (INIS)

Mukaida, Hidenori; Hirai, Toshihiro; Yamashita, Yoshinori; Yoshida, Kazuhiro; Hihara, Jun; Kuwahara, Masaki; Inoue, Hideki; Toge, Tetsuya

1998-01-01

The aim of this study was to evaluate the efficacy of adjuvant chemoradiotherapy following surgery in patients with advanced esophageal cancer. We followed the cases of 57 such patients treated at our hospital, involving 19 who received adjuvant chemoradiotherapy (CR group), 19 who received radiotherapy alone (R group), and 19 who did received neither (N group). In the CR group, chemotherapy, consisting of cis-diaminodichloroplatinum (CDDP), 5-fluorouracil (5-FU), and etoposide (VP-16), was combined with radiotherapy was administered from 4 weeks after surgery. Concurrent radiotherapy was started at 3 weeks after esophagectomy. CDDP at 50 mg/m 2 was administered on days 1 and 7.5-FU at 500 mg/m 2 and VP-16 at 60 mg/m 2 were administered on days 3, 4, and 5. Thirteen patients (68.4%) were treated with more than 2 cycles of chemotherapy combined with radiation. Side-effects of severe anorexia (grade 3) and leukocytopenia (<1900/μl) were observed in 47% and 39% of the patients, respectively. However no treatment-related death was observed. The 5-year-survival rate was 25.2%, 18.9%, and 15.8%, in the CR group, R group, and N group, respectively. The recurrence rate was 66.7% in the CR group, which was higher than in the matched control groups (46.2% in the N group and 54.5% in the R group), but with no significant difference. These results suggested that adjuvant chemoradiotherapy did not contribute to improvement in prognosis for these patients with advanced esophageal cancer. (author)

Concurrent hyperfractionated accelerated radiotherapy with 5-FU and once weekly cisplatin in locally advanced head and neck cancer. The 10-year results of a prospective phase II trial

Energy Technology Data Exchange (ETDEWEB)

Budach, V.; Boehmer, D.; Badakhshi, H.; Jahn, U.; Stromberger, C. [Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Department for Radiooncology, Clinic for Radiooncology, Berlin (Germany); Becker, E.T. [Charite Universitaetsmedizin, Department of Otorhinolaryngology, Berlin (Germany); Wernecke, K.D. [Sostana Statistics GmbH, Charite Universitaetsmedizin Berlin, Berlin (Germany)

2014-03-15

In this study, the acute toxicity and long-term outcome of a hyperfractionated accelerated chemoradiation regimen with cisplatin/5-fluorouracil (5-FU) in patients with locally advanced squamous cell carcinomas of head and neck were evaluated. From 2000-2002, 38 patients with stage III (5.3 %) and stage IV (94.7 %) head and neck cancer were enrolled in a phase II study. Patients received hyperfractionated-accelerated radiotherapy with 72 Gy in 15 fractions of 2 Gy followed by 1.4 Gy twice daily with concurrent, continuous infusion 5-FU of 600 mg/m{sup 2} on days 1-5 and 6 cycles of weekly cisplatin (30 mg/m{sup 2}). Acute toxicities (CTCAEv2.0), locoregional control (LRC), metastases-free (MFS), and overall survival (OS) were analyzed and exploratively compared with the ARO 95-06 trial. Median follow-up was 11.4 years (95 % CI 8.6-14.2) and mean dose 71.6 Gy. Of the patients, 82 % had 6 (n = 15) or 5 (n = 16) cycles of cisplatin, 5 and 2 patients received 4 and 3 cycles, respectively. Grade 3 anemia, leukopenia, and thrombocytopenia were observed in 15.8, 15.8, and 2.6 %, respectively. Grade 3 mucositis in 50 %, grade 3 and 4 dysphagia in 55 and 13 %. The 2-, 5-, and 10-year LRC was 65, 53.6, and 48.2 %, the MFS was 77.5, 66.7, and 57.2 % and the OS 59.6, 29.2, and 15 %, respectively. Chemoradiation with 5-FU and cisplatin seems feasible and superior in terms of LRC and OS to the ARO 95-06C-HART arm at 2 years. However, this did not persist at the 5- and 10-year follow-ups. (orig.) [German] Untersuchung der Akuttoxizitaet und des Langzeitueberlebens einer hyperfraktioniert-akzelerierten simultanen Radiochemotherapie mit Cisplatin/5-Fluorouracil (5-FU) bei Patienten mit lokal fortgeschrittenen Kopf-Hals-Tumoren. Von 2000 bis 2002 wurden 38 Patienten mit Plattenepithelkarzinomen der Kopf-Hals-Region im Stadium III (5,3 %) und IV (94,7 %) eingeschlossen. Es erfolgte eine simultane hyperfraktionierte akzelerierte Radiochemotherapie mit 72 Gy in 15 Fraktionen a 2 Gy

High-power microwave transmission systems for electron cyclotron resonance plasma heating

International Nuclear Information System (INIS)

Vernon, R.J.

1990-08-01

This progress report is for the fifth year of a grant from the US Department of Energy (Contract FG02-85ER52122) for the design, development, and fabrication of ECRF transmission and mode conversion systems to transport microwave power from a gyrotron, or other high power source, to a magnetically confined plasma. (This period is also the second year covered by a three-year renewal proposal submitted in June of 1988.) The development of new and improved components for such systems and underlying theory, where necessary, is the focus of this project. Devising and improving component testing and diagnostic techniques is also an important part of this effort. The development of possible designs for sections of gyrotrons themselves, such as tapers or Vlasov-type launchers, in support of the Varian gyrotron development program is also considered in this work

Summary report of Japan-US joint project (TITAN). FuY 2007-2012

International Nuclear Information System (INIS)

Okuno, K.; Muroga, T.

2014-01-01

This report summarizes the scientific accomplishments achieved through the TITAN Japan-US Collaboration Program. The TITAN collaboration (Tritium, Irradiation and Thermofluid for America and Nippon) has been carried out through six years (FuY 2007-2012) under the collaboration implemented by establishing Annex I to the NIFS-ORNL Agreement on Academic and Scientific Exchange. The TITAN collaboration was established to obtain fundamental understanding for the control of tritium and thermofluid in first wall, blanket and recovery systems with particular emphasis on their interfacial issues. The experiments were designed for testing under conditions specific to fusion, such as intense irradiation, high heat/particle flux, and circulation in a high magnetic field. The results have been applied using integrated modeling to advance the design of tritium and heat control in MFE and IFE systems. This issue is the collection of 34 papers presented at the entitled meeting. All the 34 of the presented papers are indexed individually. (J.P.N.)

Ezra Pound and Du Fu: Gazing at Mt. Tai

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Kent Su

2017-08-01

Full Text Available Confined to a six-by-six-foot outdoor steel cage, Ezra Pound saw a series of mountain hills from a few miles to the east of Pisa. The poet compared one of these small 800-metre hills to the sacred Chinese Mt. Tai, which becomes the most common geographical name in The Pisan Cantos. Pound’s poetic summoning of this particular mountain is related to the fact that Mt. Tai is historically and culturally connected to the philosophy of Confucius, who personally ascended the mountain several times. Pound, as a devout Confucian disciple, closely follows the philosophical doctrines and attempts to mentally trace the footsteps of Confucius. This paper will argue how Pound’s poetic evocation of the mountain shares a striking similarity to an eighth-century Chinese poem called “Gazing at Mt. Tai,” which was written by the famous literatus - Du Fu 杜甫(712 – 770 . In spite of living in two completely different eras and countries, Pound’s and Du Fu’s reference to Mt. Tai demonstrates the confluence of their poetic spirits. Neither of them ascended mountain personally. They instead made use of their poetic imagination to follow the paths of Confucius and perceived the mountain as an earthly paradise, one which represents tranquillity and serenity away from the moral and physical corruption of the external world.

Mass loss from pre-main-sequence accretion disks. I - The accelerating wind of FU Orionis

Science.gov (United States)

Calvet, Nuria; Hartmann, Lee; Kenyon, Scott J.

1993-01-01

We present evidence that the wind of the pre-main-sequence object FU Orionis arises from the surface of the luminous accretion disk. A disk wind model calculated assuming radiative equilibrium explains the differential behavior of the observed asymmetric absorption-line profiles. The model predicts that strong lines should be asymmetric and blueshifted, while weak lines should be symmetric and double-peaked due to disk rotation, in agreement with observations. We propose that many blueshifted 'shell' absorption features are not produced in a true shell of material, but rather form in a differentially expanding wind that is rapidly rotating. The inference of rapid rotation supports the proposal that pre-main-sequence disk winds are rotationally driven.

Anti-mitotic potential of 7-diethylamino-3(2′-benzoxazolyl)-coumarin in 5-fluorouracil-resistant human gastric cancer cell line SNU620/5-FU

International Nuclear Information System (INIS)

Kim, Nam Hyun; Kim, Su-Nam; Oh, Joa Sub; Lee, Seokjoon; Kim, Yong Kee

2012-01-01

Highlights: ► DBC exerts antiproliferative potential against 5FU-resistant human gastric cancer cells. ► This effect is mediated by destabilization of microtubules and subsequent mitotic arrest. ► DBC enhances apoptosis via caspase activation and downregulation of antiapoptotic genes. -- Abstract: In this study, we investigate an anti-mitotic potential of the novel synthetic coumarin-based compound, 7-diethylamino-3(2′-benzoxazolyl)-coumarin, in 5-fluorouracil-resistant human gastric cancer cell line SNU-620-5FU and its parental cell SNU-620. It exerts the anti-proliferative effects with similar potencies against both cancer cells, which is mediated by destabilization of microtubules and subsequent mitotic arrest. Furthermore, this compound enhances caspase-dependent apoptotic cell death via decreased expression of anti-apoptotic genes. Taken together, our data strongly support anti-mitotic potential of 7-diethylamino-3(2′-benzoxazolyl)-coumarin against drug-resistant cancer cells which will prompt us to further develop as a novel microtubule inhibitor for drug-resistant cancer chemotherapy.

Preliminary clinical evaluation of continuous infusion of 5-FU and low-dose cisplatin (LFP) therapy alone and combined with radiation therapy for treatment of advanced or recurrent esophageal cancer

International Nuclear Information System (INIS)

Itoh, Satoshi; Morita, Sojiro; Ohnishi, Takenao; Tsuji, Akihito; Takamatsu, Masahiro; Horimi, Tadashi

2002-01-01

We evaluated the clinical effect of 5-FU and low-dose Cisplatin (LFP) therapy alone and LFP therapy combined with radiation therapy in patients with advanced or recurrent esophageal cancer. From March 1995 to September 2000, 11 patients with inoperable esophageal cancer, 8 patients with adjuvant chemotherapy post operation, and 14 patients with recurrent esophageal cancer were treated with LFP therapy. 5-FU (160 mg/m 2 /day) was continuously infused over 24 hours, and CDDP (3-7 mg/m 2 /day) was infused for 30 minutes. The administration schedule consisted of 5-FU for 7 consecutive days and CDDP for 5 days followed by a 2-day rest, each for four weeks. We combined radiation therapy for the patients with all lesions that could be included in the radiation field. Of 30 patients with measurable lesions the response rates of LFP therapy alone and LFP therapy combined with radiation therapy were 33% and 60%, respectively. Toxicity over grade 3 appeared in 3 of 15 patients with LFP therapy combined with radiation therapy. There was no significant difference between LFP therapy alone and LFP therapy combined with radiation therapy with regard to survival rate of inoperable and recurrent esophageal cancer. In conclusion, LFP therapy alone may be effective for esophageal cancer. (author)

Investigation on heat transfer analysis and its effect on a multi-mode, beam-wave interaction for a 140 GHz, MW-class gyrotron

Science.gov (United States)

Liu, Qiao; Liu, Yinghui; Chen, Zhaowei; Niu, Xinjian; Li, Hongfu; Xu, Jianhua

2018-04-01

The interaction cavity of a 140 GHz, 1 MW continuous wave gyrotron developed in UESTC will be loaded with a very large heat load in the inner surface during operation. In order to reduce the heat, the axial wedge grooves of the outside surface of the cavity are considered and employed as the heat radiation structure. Thermoanalysis and structural analysis were discussed in detail to obtain the effects of heat on the cavity. In thermoanalysis, the external coolant-flow rates ranging from 20 L/min to 50 L/min were considered, and the distribution of wall loading was loaded as the heat flux source. In structural analysis, the cavity's deformation caused by the loads of heat and pressure was calculated. Compared with a non-deformed cavity, the effects of deformation on the performance of a cavity were discussed. For a cold-cavity, the results show that the quality factor would be reduced by 72, 89, 99 and 171 at the flow rates of 50 L/min, 40 L/min, 30 L/min and 20 L/min, respectively. Correspondingly, the cold-cavity frequencies would be decreased by 0.13 GHz, 0.15 GHz, 0.19 GHz and 0.38 GHz, respectively. For a hot-cavity, the results demonstrate that the output port frequencies would be dropped down, but the offset would be gradually decreased with increasing coolant-flow rate. Meanwhile, the output powers would be reduced dramatically with decreasing coolant-flow rate. In addition, when the coolant-flow rate reaches 40 L/min, the output power and the frequency are just reduced by 30 kW and 0.151 GHz, respectively.

Modelling RF sources using 2-D PIC codes

Energy Technology Data Exchange (ETDEWEB)

Eppley, K.R.

1993-03-01

In recent years, many types of RF sources have been successfully modelled using 2-D PIC codes. Both cross field devices (magnetrons, cross field amplifiers, etc.) and pencil beam devices (klystrons, gyrotrons, TWT'S, lasertrons, etc.) have been simulated. All these devices involve the interaction of an electron beam with an RF circuit. For many applications, the RF structure may be approximated by an equivalent circuit, which appears in the simulation as a boundary condition on the electric field ( port approximation''). The drive term for the circuit is calculated from the energy transfer between beam and field in the drift space. For some applications it may be necessary to model the actual geometry of the structure, although this is more expensive. One problem not entirely solved is how to accurately model in 2-D the coupling to an external waveguide. Frequently this is approximated by a radial transmission line, but this sometimes yields incorrect results. We also discuss issues in modelling the cathode and injecting the beam into the PIC simulation.

Modelling RF sources using 2-D PIC codes

Energy Technology Data Exchange (ETDEWEB)

Eppley, K.R.

1993-03-01

In recent years, many types of RF sources have been successfully modelled using 2-D PIC codes. Both cross field devices (magnetrons, cross field amplifiers, etc.) and pencil beam devices (klystrons, gyrotrons, TWT`S, lasertrons, etc.) have been simulated. All these devices involve the interaction of an electron beam with an RF circuit. For many applications, the RF structure may be approximated by an equivalent circuit, which appears in the simulation as a boundary condition on the electric field (``port approximation``). The drive term for the circuit is calculated from the energy transfer between beam and field in the drift space. For some applications it may be necessary to model the actual geometry of the structure, although this is more expensive. One problem not entirely solved is how to accurately model in 2-D the coupling to an external waveguide. Frequently this is approximated by a radial transmission line, but this sometimes yields incorrect results. We also discuss issues in modelling the cathode and injecting the beam into the PIC simulation.

Modelling RF sources using 2-D PIC codes

International Nuclear Information System (INIS)

Eppley, K.R.

1993-03-01

In recent years, many types of RF sources have been successfully modelled using 2-D PIC codes. Both cross field devices (magnetrons, cross field amplifiers, etc.) and pencil beam devices (klystrons, gyrotrons, TWT'S, lasertrons, etc.) have been simulated. All these devices involve the interaction of an electron beam with an RF circuit. For many applications, the RF structure may be approximated by an equivalent circuit, which appears in the simulation as a boundary condition on the electric field (''port approximation''). The drive term for the circuit is calculated from the energy transfer between beam and field in the drift space. For some applications it may be necessary to model the actual geometry of the structure, although this is more expensive. One problem not entirely solved is how to accurately model in 2-D the coupling to an external waveguide. Frequently this is approximated by a radial transmission line, but this sometimes yields incorrect results. We also discuss issues in modelling the cathode and injecting the beam into the PIC simulation

Electromiographic and kinematic characteristics of Kung Fu Yau-Man palm strike.

Science.gov (United States)

Neto, O P; Magini, Marcio

2008-12-01

A kinematic and electromyographic analysis of Kung Fu (KF) Yau-Man palm strikes without impact is presented. An empirical model applied to data obtained by a high-speed camera describes the kinematic characteristics of the movement. The electromyographic patterns of the biceps brachii, brachioradialis and triceps brachii muscles were studied during the strike in the time (root mean square) and frequency (wavelet transform) domains. Eight KF practitioners participated in the investigation. A wooden board was placed in front of the subjects, and they were asked to perform the strike imagining a target above the board. The results show that the Yau-Man KF palm strike has very similar kinematic characteristics to a simple moderate speed elbow extension movement. All practitioners positioned themselves in relation to the wooden board in a way to achieve their highest hand speeds in the instant their hands crossed the board. The analyses of the electromyography data shows a well developed muscle coordination of the practitioners in agreement with kinematic results. The results of this paper are important not only for improving the performance of practitioners but also to demonstrate the applicability of KF in the process of motor control development.

Architecture of central control system for the 10 MW ECRH-plant at W7-X

Energy Technology Data Exchange (ETDEWEB)

Braune, H. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany)], E-mail: harald.braune@ipp.mpg.de; Brand, P. [Universitaet Stuttgart, Institut fuer Plasmaforschung Pfaffenwaldring 31, D-70569 Stuttgart (Germany); Erckmann, V.; Jonitz, L. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Leonhardt, W.; Mellein, D. [Forschungszentrum Karlsruhe, Association EURATOM-FZK, IHM, FZK, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Michel, G. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Mueller, G. [Universitaet Stuttgart, Institut fuer Plasmaforschung Pfaffenwaldring 31, D-70569 Stuttgart (Germany); Purps, F. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Schlueter, K.-H. [Universitaet Stuttgart, Institut fuer Plasmaforschung Pfaffenwaldring 31, D-70569 Stuttgart (Germany); Winkler, M. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany)

2007-10-15

Electron Cyclotron Resonance Heating (ECRH) is the main heating method for the Wendelstein 7-X stellarator (W7-X) which is presently under construction at IPP Greifswald. The mission of W7-X is to demonstrate the inherent steady state capability of stellarators at reactor relevant plasma parameters. A modular 10 MW ECRH-plant at 140 GHz with 1 MW CW-capability power for each module is also under construction to support the scientific objectives. The commissioning of the ECRH-plant is well under way; three gyrotrons are operational. The strict modular design allows to operate each gyrotron separately and independent from all others. The ECRH-plant consists of many devices such as gyrotrons and high voltage power supplies, superconductive magnets, collector sweep coils, gyrotron cooling systems with many water circuits and last but not least the quasi-optical transmission line for microwaves with remote controlled mirrors and further water cooled circuits. All these devices are essential for a CW operation. A steady state ECRH has specific requirements on the stellarator machine itself, on the microwave sources, transmission elements and in particular on the central control system. The quasi steady state operation (up to 30 min) asks for real time microwave power adjustment during the different segments of one stellarator discharge. Therefore, the ECRH-plant must operate with a maximum reliability and availability. A capable central control system is an important condition to achieve this goal. The central control system for the 10 MW ECRH-plant at W7-X comprises three main parts. In detail these are the voltage and current regulation of each gyrotron, the interlock system to prevent the gyrotrons from damages and the remote control system based on a hierarchy set of PLCs and computers. The architecture of this central control system is presented.

Operation of a quasioptical electron cyclotron maser

International Nuclear Information System (INIS)

Morse, E.C.; Pyle, R.V.

1984-12-01

The electron cyclotron maser or gyrotron concept has been developed to produce sources producing 200 kW at 28 GHz continuously, and higher power outputs and frequencies in pulsed mode. These sources have been useful in electron cyclotron resonance heating (ECRH) in magnetically confined fusion devices. However, higher frequencies and higher power levels will be required in reactor-grade fusion plasmas, with likely requirements of 1.0 MW or more per source at 140 GHz. Conventional gyrotrons follow a trend of decreasing power for increasing frequency. In order to circumvent this problem, the quasioptical electron cyclotron maser was proposed. In this device, the closed resonator of the conventional gyrotron is replaced with an open, Fabry-Perot type resonator. The cavity modes are then the TEM-type modes of an optical laser. The advantage of this configuration is that the cavity size is not a function of frequency, since the length can be any half-integer number of wavelengths. Furthermore, the beam traverses across the cavity transverse to the direction of radiation output, and thus the rf window design is less complicated than in conventional tubes. The rf output, if obtained by diffraction coupling around one of the mirrors, could be in a TEM mode, which would allow for quasioptical transmission of the microwaves into the plasma in fusion devices. 4 references, 1 figure

Combination hyperthermia and intraarterial 5-FU for metastatic colon carcinoma to liver

International Nuclear Information System (INIS)

Moseley, H.S.; Palmquist, M.

1984-01-01

Metastatic colorectal carcinoma to the liver remains a formidable challenge. Responses to chemotherapy are brief and the number of effective drugs is very limited. A phase II trial of hepatic hyperthermia and intraarterial chemotherapy was undertaken to attempt to improve response rates and duration. Patients were given a 10 day course of IA 5-FU at 15 mg/kg. During the infusion hyperthermia was given five times using the BSD Annular Phased Array (APA). Thermistors were placed percutaneously into normal liver and tumor using ultrasound or CT scan guidance. Six patients have been treated. Significant problems in positioning ill patients in the APA were encountered, and there was difficulty also in preventing heating throughout the abdominal cavity. Four patients, all with poor performance status, failed to benefit. One patient had improvement in liver function studies for two months and failed to respond on a repeat course. One patient had a complete response which is continuing over 18 months with a liver scan reverting to normal and CEA returning to normal. These preliminary results are promising and warrant further trials

Fußball und Identität in Israel - Die Rolle der Medien im Kontext politisch-kultureller Identitätsbildung und Ausgrenzungsprozesse

Directory of Open Access Journals (Sweden)

Michael Schuster

2010-03-01

Full Text Available Eine gängige These besagt, dass sich im Sport gesellschaftliche Konflikte widerspiegeln. Insbesondere dem Fußball wird unterstellt, eine Arena zur Artikulation und Repräsentation exklusiver Identität nationaler Minderheiten zu bieten. Der vorliegende Artikel widmet sich dem Thema der politisch-kulturellen Identitätsbildung in fragmentierten Gesellschaften. Am Beispiel der arabischen Minderheit in Israel wird dargestellt, dass unter bestimmten gesellschaftlichen Konstellationen der Fußball als Element der Popularkultur dem Staat auch als Mittel der Unterdrückung eines nationalen Minderheitenbewusstseins dienen kann. Unter Zuhilfenahme der Hegemonietheorie Antonio Gramscis kann das Entstehen einer pro-israelischen Identität der arabischen Minderheit - in Abgrenzung zu einer eigenen, arabischen oder widerständigen Identität - im Kontext des Fußballs rekonstruiert werden. Zu diesem Zweck wird aufgezeigt, welche Bedeutungs- und Definitionsmacht hebräische und arabische Sportmedien als Akteure divergierender Bedeutungszuschreibungen in dem Konfliktfeld der Herausbildung politisch-kultureller Identitäten besitzen und ihrerseits vorherrschende Integrations- und Dominanzprozesse beeinflussen. It is a widespread/popular thesis that sports are a useful means to display social conflicts; in particular it is argued that football offers a platform for the articulation and representation of the identity of ethnic/national/(cultural minorities. This article focuses on the construction of identity in fragmented societies with the help of politics and culture. With the example of the Arab minority in Israel it is portrayed here, that under particular social circumstances football can be used as an element of popular culture to repress the cultural and political identity of minorities. Gramsci's theory of hegemony explains the construction of a pro-Israel identity among the Arab minority which differs from their own Arab identity. It is shown here to

Observation of dynamic interactions between fundamental and second-harmonic modes in a high-power sub-terahertz gyrotron operating in regimes of soft and hard self-excitation.

Science.gov (United States)

Saito, Teruo; Tatematsu, Yoshinori; Yamaguchi, Yuusuke; Ikeuchi, Shinji; Ogasawara, Shinya; Yamada, Naoki; Ikeda, Ryosuke; Ogawa, Isamu; Idehara, Toshitaka

2012-10-12

Dynamic mode interaction between fundamental and second-harmonic modes has been observed in high-power sub-terahertz gyrotrons [T. Notake et al., Phys. Rev. Lett. 103, 225002 (2009); T. Saito et al. Phys. Plasmas 19, 063106 (2012)]. Interaction takes place between a parasitic fundamental or first-harmonic (FH) mode and an operating second-harmonic (SH) mode, as well as among SH modes. In particular, nonlinear excitation of the parasitic FH mode in the hard self-excitation regime with assistance of a SH mode in the soft self-excitation regime was clearly observed. Moreover, both cases of stable two-mode oscillation and oscillation of the FH mode only were observed. These observations and theoretical analyses of the dynamic behavior of the mode interaction verify the nonlinear hard self-excitation of the FH mode.

Neoadjuvant Treatment With Single-Agent Cetuximab Followed by 5-FU, Cetuximab, and Pelvic Radiotherapy: A Phase II Study in Locally Advanced Rectal Cancer

International Nuclear Information System (INIS)

Bertolini, Federica; Chiara, Silvana; Bengala, Carmelo; Antognoni, Paolo; Dealis, Cristina; Zironi, Sandra; Malavasi, Norma; Scolaro, Tindaro; Depenni, Roberta; Jovic, Gordana; Sonaglio, Claudia; Rossi, Aldo; Luppi, Gabriele; Conte, Pier Franco

2009-01-01

Purpose: Preoperative chemoradiotherapy followed by surgery represents the standard of care for locally advanced rectal cancer (LARC). Cetuximab has proved activity in advanced colorectal cancer, and its incorporation in preoperative treatment may increase tumor downstaging. Methods and Materials: After biopsy and staging, uT3/uT4 N0/+ LARC received single-agent cetuximab in three doses, followed by weekly cetuximab plus 5-fluorouracil (5-FU), concomitantly with RT. Sample size was calculated according to Bryant and Day test, a two-stage design with at least 10 pathologic complete remissions observed in 60 patients (pts) able to complete the treatment plan. Results: Forty pts with LARC were entered: male/female = 34/6; median age: 61 (range, 28-77); 12 uT3N0 Ed(30%); 25 uT3N1 (62%); 3 uT4N1 (8%); all Eastern Cooperative Oncology Group = 0. Thirty-five pts completed neoadjuvant treatment; 5 (12%) withdrew therapy after one cetuximab administration: three for hypersensitivity reactions, one for rapid progression, and one for purulent arthritis. They continued 5-FU in continuous infusion in association with RT. Thirty-one pts (77%) presented with acnelike rash; dose reduction/interruption of treatment was necessary in six pts (15%): two for Grade 3 acnelike rash, two for Grade 3 gastrointestinal toxicity, and two for refusal. Thirty-eight pts were evaluable for pathological response (one patient refused surgery, and one was progressed during neoadjuvant treatment). Pathological staging was: pT0N0 three pts (8%), pT1N0 1 pt (3%); pT2N0 13 pts (34%), and pT3 19 pts (50%) (N0:9, N1:5; N2:5); pT4 2 pts (5%). Conclusions: Preoperative treatment with 5-FU, cetuximab, and pelvic RT is feasible with acceptable toxicities; however, the rate of pathologic responses is disappointingly low

Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells

Directory of Open Access Journals (Sweden)

Sun Xiao-Feng

2010-11-01

Full Text Available Abstract Background MicroRNAs (miRNAs are endogenously expressed noncoding RNAs with important biological and pathological functions. Although several studies have shown that microRNA-31 (miR-31 is obviously up-regulated in colorectal cancer (CRC, there is no study on the functional roles of miR-31 in CRC. Methods Anti-miR™ miRNA 31 inhibitor (anti-miR-31 is a sequence-specific and chemically modified oligonucleotide to specifically target and knockdown miR-31 molecule. The effect of anti-miR-31 transfection was investigated by real-time PCR. HCT-116p53+/+ and HCT-116p53-/-colon cancer cells were treated by anti-miR-31 with or without 5-fluorouracil (5-FU, cell proliferation was determined by MTT assay; apoptosis was detected by DAPI staining; cell cycle was evaluated by flow cytometry; colony formation, migration and invasion assays were performed to investigate the effect of suppression of miR-31 on the cell lines. Results Real-time PCR results showed that anti-miR-31 was efficiently introduced into the cells and reduced miR-31 levels to 44.1% in HCT-116p53+/+ and 67.8% in HCT-116p53-/-cell line (p = 0.042 and 0.046. MTT results showed that anti-miR-31 alone had no effect on the proliferation of HCT-116p53+/+ or HCT-116p53-/-. However, when combined with 5-FU, anti-miR-31 inhibited the proliferation of the two cell lines as early as 24 h after exposure to 5-FU (p = 0.038 and 0.044. Suppression of miR-31 caused a reduction of the migratory cells by nearly 50% compared with the negative control in both HCT-116p53+/+ and HCT-116p53-/-(p = 0.040 and 0.001. The invasive ability of the cells were increased by 8-fold in HCT-116p53+/+ and 2-fold in HCT-116p53-/- (p = 0.045 and 0.009. Suppression of miR-31 had no effect on cell cycle and colony formation (p > 0.05. Conclusions Suppression of miR-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells.

Validation of the 12-gene colon cancer recurrence score in NSABP C-07 as a predictor of recurrence in patients with stage II and III colon cancer treated with fluorouracil and leucovorin (FU/LV) and FU/LV plus oxaliplatin.

Science.gov (United States)

Yothers, Greg; O'Connell, Michael J; Lee, Mark; Lopatin, Margarita; Clark-Langone, Kim M; Millward, Carl; Paik, Soonmyung; Sharif, Saima; Shak, Steven; Wolmark, Norman

2013-12-20

Accurate assessments of recurrence risk and absolute treatment benefit are needed to inform colon cancer adjuvant therapy. The 12-gene Recurrence Score assay has been validated in patients with stage II colon cancer from the Cancer and Leukemia Group B 9581 and Quick and Simple and Reliable (QUASAR) trials. We conducted an independent, prospectively designed clinical validation study of Recurrence Score, with prespecified end points and analysis plan, in archival specimens from patients with stage II and III colon cancer randomly assigned to fluorouracil (FU) or FU plus oxaliplatin in National Surgical Adjuvant Breast and Bowel Project C-07. Recurrence Score was assessed in 892 fixed, paraffin-embedded tumor specimens (randomly selected 50% of patients with tissue). Data were analyzed by Cox regression adjusting for stage and treatment. Continuous Recurrence Score predicted recurrence (hazard ratio for a 25-unit increase in score, 1.96; 95% CI, 1.50 to 2.55; P < .001), as well as disease-free and overall survival (both P < .001). Recurrence Score predicted recurrence risk (P = .001) after adjustment for stage, mismatch repair, nodes examined, grade, and treatment. Recurrence Score did not have significant interaction with stage (P = .90) or age (P = .76). Relative benefit of oxaliplatin was similar across the range of Recurrence Score (interaction P = .48); accordingly, absolute benefit of oxaliplatin increased with higher scores, most notably in patients with stage II and IIIA/B disease. The 12-gene Recurrence Score predicts recurrence risk in stage II and stage III colon cancer and provides additional information beyond conventional clinical and pathologic factors. Incorporating Recurrence Score into the clinical context may better inform adjuvant therapy decisions in stage III as well as stage II colon cancer.

Therapeutic effect of intra-arterial chemotherapy with DDP and 5-FU via bilateral uterine arteries for advanced uterine cervical cancer

International Nuclear Information System (INIS)

Zhou Kang; Li Xiaoguang; Jin Zhengyu; Yang Ning; Liu Wei; Pan Jie; Zhang Xiaobo; Shi Haifeng; Sun Hao; Wang Zhiwei

2010-01-01

Objective: To evaluate the therapeutic effect of intra-arterial chemotherapy with Ddp and 5-Fu via bilateral uterine arteries for advanced uterine cervical cancer. Methods: During the period of Jan. 2006-Jan. 2009, initial intra-arterial chemotherapy by using a combination of Ddp and 5-Fu via bilateral uterine arteries was performed in 72 patients (mean age 42.9 years) with advanced uterine cervical caner. Of 72 patients, stage I b2 cervical cancer was confirmed in 28, stage II a in 12 and stage II b in 32. Pathologically, cervical squamous cell carcinoma was seen in 56 and cervical adenocarcinoma in 16 patients. Ultrasonography and physical examination were conducted both before and after intra-arterial chemotherapy. The therapeutic results,complications,the surgical resection rate and the pathologic findings were observed and statistically analyzed. Results: Fifty-four patients received one treatment course and 18 patients received two treatment courses. The over all response rate was 77.8%. The response rates of patients with I b2, II a and II b cervical cancer were 92.9%, 83.3% and 62.5% respectively, the difference between three groups was statistically significant (P < 0.05). And the response rates of patients with squamous cell carcinoma and adenocarcinoma were 85.7% and 50.0% respectively, the difference between the two was statistically significant (P < 0.05). The most common side-effects included gastrointestinal symptoms and bone marrow suppression. Thirty-four patients received radical hysterectomy,among them, 22 (78.6%) had stage I b2, 8 (66.7%) had stage II a and 4 (12.5%) had stage II b cervical cancer (P < 0.05). Pathologic exam found no vaginal invasion and ovarian metastasis in all 34 patients. The occurrence of metastasis to lymph nodes and para uterine infiltration were 17.6% and 11.8% respectively. Conclusion: Intra-arterial chemotherapy with a combination of DDP and 5-Fu via bilateral uterine arteries can safely and effectively reduce the

USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt.

Science.gov (United States)

Zhang, Jing; Luo, Nan; Tian, Yu; Li, Jiazhi; Yang, Xiaozhou; Yin, Huimin; Xiao, Congshu; Sheng, Jie; Li, Yang; Tang, Bo; Li, Rongkuan

2017-04-11

USP22, a member of the deubiquitinases (DUBs) family, is known to be a key subunit of the human Spt-Ada-Gcn5 acetyltransferase (hSAGA) transcriptional cofactor complex. Within hSAGA, USP22 removes ubiquitin from histone proteins, thus regulating the transcription and expression of downstream genes. USP22 plays important roles in many cancers; however, its effect and the mechanism underlying HCC chemoresistance remain unclear. In the present study, we found that USP22 was highly expressed in chemoresistant HCC tissues and cells and was correlated with the prognosis of HCC patients who received chemotherapy. Silencing USP22 in chemoresistant HCC Bel/Fu cells dramatically inhibited proliferation, migration, invasion and epithelial-mesenchymal transition in vitro; suppressed tumorigenic and metastatic capacities in vivo; and inhibited drug resistance-related proteins (MDR1, LRP, MRP1). Mechanistically, we found that USP22 knockdown exerts its function through down-regulating PI3K and activating Smad4, which inhibited phosphorylation of Akt. Silencing Smad4 blocked USP22 knockdown-induced Akt inhibition in Bel/Fu cells. Our results, for the first time, provide evidence that USP22 plays a critical role in the development of chemoresistant HCC cells and that high USP22 expression serves as a molecular marker for the prognosis of HCC patients who undergo chemotherapy.

The Protective Effects of Shen-Fu Injection on Experimental Acute Pancreatitis in a Rat Model

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Lei Huang

2014-01-01

Full Text Available Objectives. In the present study, we investigated the protective effects of Shen-Fu injection (SFI on a caerulein-induced rat pancreatitis (AP model. Methods. SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies. Results. Our results showed that AP caused significant decrease in tissue glutathione (GSH and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA and myeloperoxidase (MPO were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein. Conclusion. Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB activity.

Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization

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Isayama Teruto

2010-11-01

Full Text Available Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FISH, Urovysion™ FISH, and comparative genomic hybridization (CGH for the characterization of chromosomal aberrations. FU-MFH-2 cells were spindle or polygonal in shape with oval nuclei, and were successfully maintained in vitro for over 80 passages. The histological features of heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor. Cytogenetic and M-FISH analyses displayed a hypotriploid karyotype with numerous structural aberrations. Urovysion™ FISH revealed a homozygous deletion of the p16INK4A locus on chromosome band 9p21. CGH analysis showed a high-level amplification of 9q31-q34, gains of 1p12-p34.3, 2p21, 2q11.2-q21, 3p, 4p, 6q22-qter, 8p11.2, 8q11.2-q21.1, 9q21-qter, 11q13, 12q24, 15q21-qter, 16p13, 17, 20, and X, and losses of 1q43-qter, 4q32-qter, 5q14-q23, 7q32-qter, 8p21-pter, 8q23, 9p21-pter, 10p11.2-p13, and 10q11.2-q22. Conclusion The FU-MFH-2 cell line will be a particularly useful model for studying molecular pathogenesis of human pleomorphic MFH.

A randomised placebo-exercise controlled trial of Kung Fu training for improvements in body composition in overweight/obese adolescents: the "Martial Fitness" study.

Science.gov (United States)

Tsang, Tracey W; Kohn, Michael; Chow, Chin Moi; Singh, M Fiatarone

2009-01-01

The purpose of the study was to investigate if Chinese martial arts (Kung Fu, KF) might be effective for improving body composition, as well as being an appealing form of physical activity for inexperienced, sedentary, overweight/obese adolescents. Twenty subjects (age: 13.3 ± 1.8 y; BMI percentile: 98.6(86.5 - 99.8); 60% girls) were randomly-assigned to the supervised KF or placebo (Tai Chi, TC) control group 3 d.wk(-1) for 6 months. We assessed body composition, including total and regional fat and lean mass, total and regional bone mineral density (BMD), percent lean and fat mass, body mass index and waist circumference, at baseline and after 6 months of training using anthropometry and dual-energy X-ray absorptiometry (DXA). Habitual physical activity and dietary intake were recorded as covariates via self-report at each time-point. As expected due to natural growth, significant increases in height, weight, total and lumbar BMD, and lean mass were seen in the cohort over time, with a trend for increased whole body fat mass, with no difference between groups. By contrast, percent fat and android fat mass via DXA did not increase in either group over time. The absence of a similar expected increase in central adiposity over 6 months could indicate a positive effect of participation in both programs on the metabolically critical abdominal adiposity in this cohort. Further research in this area is warranted to determine ways to increase uptake and compliance, and to see if longer-term martial arts training not only maintains, but improves abdominal fat mass and related metabolic health indices in overweight/ obese adolescents. Key pointsParticipation in our martial arts trial attenuated the increases in body fat mass expected due to growth in our overweight/obese adolescent group.All subjects allocated to the Kung Fu intervention were satisfied with their Kung Fu training, in contrast to our placebo-exercise (Tai Chi) subjects, suggesting that this form of

Wavelet-Transform-Based Power Management of Hybrid Vehicles with Multiple On-board Energy Sources Including Fuel Cell, Battery and Ultracapacitor

Science.gov (United States)

2008-09-12

considered to be promising for application as distributed generation sources due to high efficiency and compactness [1-2], [21-24]. The PEMFC is...also a primary candidate for environment-friendly vehicles. The nomenclatures of the PEMFC are as follows: B , C : Constants to calculate the...0 O H H-O H-O 1 2 N I q q r r FU = (10) The block diagram of the PEMFC model based on the above equations is shown in Fig

[Experimental study on preventing postoperative posterior urethra scar in response to Tablet Fu Kang].

Science.gov (United States)

Mo, Jiacong; Wang, Shengyi

2004-07-01

To find an effective measurement to prevent and decrease the posterior urethral scar stricture. Twenty New Zealand rabbits were chosen. All the rabbits were made posterior urethra disruption model, and at the same time, the urethra anastomosis operation was performed. Twenty rabbits were divided into two groups after operation at random. One group was treated by Tablet Fu Kang (experimental group), another group was treated by NS (control group). All the rabbits were killed three weeks later, the urethra anastomotic stoma tissue was chosen and stained with Masson. All the figures of slides were inputted into figure analytic system. There were little collagenous fiber, sparsely and arranged in good order in scar tissue of urethra anastomotic stoma in experimental group. The area of collagenous fibers was 117.11 +/- 10.17 microm2 in three visual fields. There were many collagenous fibers, densely,and arranged in disorder in scar tissue of urethra anastomotic stoma in control group, the relative area was 136.43 +/- 15.85 microm2. There was statistic significance when comparing the area of collagenous fiber in two groups (P urethra.

Effects of Shen-Fu Injection on the Expression of T-Cell-Specific Transcription Factors T-bet/Gata-3 in Porcine Postresuscitation Lung Injury

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Wei Gu

2013-01-01

Full Text Available Shen-Fu injection (SFI derived from the ancient traditional Chinese medicine. In this study, the effects of SFI on the expression of T-bet/GATA-3 and its potential mechanisms causing the shift of T cells from Th2 to Th1 on postresuscitation lung injury were examined in a porcine model of cardiac arrest. 30 pigs were randomly divided into SHAM ( and three return of spontaneous circulation (ROSC groups ( per group; 24 pigs were subjected to 8 min of electrically induced cardiac arrest and 2 min of basic life support, which received central venous injection of Shen-Fu (SFI, epinephrine (EP or saline (SA. After successful ROSC, 18 surviving pigs were sacrificed at 24 h after ROSC ( per group. The levels of serum and lung tissue interleukin (IL-4 and interferon (IFN-γ were measured by ELISA, and the protein and mRNA levels of GATA-3 and T-bet in the lung tissue were determined by western blotting and quantitative real-time polymerase chain reaction, respectively. Compared with the EP and SA groups, SFI treatment reduced the levels of IL-4 (, increased levels of IFN-γ (, and induced T-bet mRNA upregulation and GATA-3 mRNA downregulation (. SFI attenuated lung injury and regulated lung immune disorders. Therefore, SFI could protect postresuscitation lung injury by modulating a Th1/Th2 imbalance.

Review of dissertation The Association Of Intelligence, Visual-Motor Functioning, And Personality Characteristics With Adaptive Behavior In Individuals With Williams Syndrome by Juhsin Trista Fu

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Florova N.B.

2015-06-01

Full Text Available Juhsin Trista Fu (Taiwan is an American clinical psychologist, doctor of philosophy (PhD, on the national register of health professionals of United States National Provider Identifiers (NPI Registry. The proposed material gives a systematic description of the dynamics of specific behavioral construct in adults in situation of genetic anomalies. The author regards this condition as a volatile state which to a certain extent responds to interventions.

Degradation of 5-FU by means of advanced (photo)oxidation processes: UV/H{sub 2}O{sub 2}, UV/Fe{sup 2+}/H{sub 2}O{sub 2} and UV/TiO{sub 2} — Comparison of transformation products, ready biodegradability and toxicity

Energy Technology Data Exchange (ETDEWEB)

Lutterbeck, Carlos Alexandre, E-mail: lutterbeck@leuphana.de [Sustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Faculty of Sustainability, Leuphana University of Lüneburg, Scharnhorststraße 1/C13, DE-21335 Lüneburg (Germany); Graduate Program in Environmental Technology, Universidade de Santa Cruz do Sul — UNISC, Av. Independência, 2293, CEP 96815-900 Santa Cruz do Sul, Rio Grande do Sul (Brazil); Wilde, Marcelo Luís, E-mail: wilde@leuphana.de [Sustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Faculty of Sustainability, Leuphana University of Lüneburg, Scharnhorststraße 1/C13, DE-21335 Lüneburg (Germany); Baginska, Ewelina, E-mail: ewelina.baginska@leuphana.de [Sustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Faculty of Sustainability, Leuphana University of Lüneburg, Scharnhorststraße 1/C13, DE-21335 Lüneburg (Germany); Leder, Christoph, E-mail: cleder@leuphana.de [Sustainable Chemistry and Material Resources, Institute of Sustainable and Environmental Chemistry, Faculty of Sustainability, Leuphana University of Lüneburg, Scharnhorststraße 1/C13, DE-21335 Lüneburg (Germany); Machado, Ênio Leandro, E-mail: enio@unisc.br [Graduate Program in Environmental Technology, Universidade de Santa Cruz do Sul — UNISC, Av. Independência, 2293, CEP 96815-900 Santa Cruz do Sul, Rio Grande do Sul (Brazil); and others

2015-09-15

The present study investigates the degradation of the antimetabolite 5-fluorouracil (5-FU) by three different advanced photo oxidation processes: UV/H{sub 2}O{sub 2}, UV/Fe{sup 2+}/H{sub 2}O{sub 2} and UV/TiO{sub 2}. Prescreening experiments varying the H{sub 2}O{sub 2} and TiO{sub 2} concentrations were performed in order to set the best catalyst concentrations in the UV/H{sub 2}O{sub 2} and UV/TiO{sub 2} experiments, whereas the UV/Fe{sup 2+}/H{sub 2}O{sub 2} process was optimized varying the pH, Fe{sup 2+} and H{sub 2}O{sub 2} concentrations by means of the Box–Behnken design (BBD). 5-FU was quickly removed in all the irradiation experiments. The UV/Fe{sup 2+}/H{sub 2}O{sub 2} and UV/TiO{sub 2} processes achieved the highest degree of mineralization, whereas the lowest one resulted from the UV/H{sub 2}O{sub 2} treatment. Six transformation products were formed during the advanced (photo)oxidation processes and identified using low and high resolution mass spectrometry. Most of them were formed and further eliminated during the reactions. The parent compound of 5-FU was not biodegraded, whereas the photolytic mixture formed in the UV/H{sub 2}O{sub 2} treatment after 256 min showed a noticeable improvement of the biodegradability in the closed bottle test (CBT) and was nontoxic towards Vibrio fischeri. In silico predictions showed positive alerts for mutagenic and genotoxic effects of 5-FU. In contrast, several of the transformation products (TPs) generated along the processes did not provide indications for mutagenic or genotoxic activity. One exception was TP with m/z 146 with positive alerts in several models of bacterial mutagenicity which could demand further experimental testing. Results demonstrate that advanced treatment can eliminate parent compounds and its toxicity. However, transformation products formed can still be toxic. Therefore toxicity screening after advanced treatment is recommendable. - Highlights: • Full primary elimination of 5-FU was

Preliminary results of pre-operative 5-FU, low dose leucovorin (LV), and concurrent radiation therapy (RT) for resectable T3 rectal cancer

International Nuclear Information System (INIS)

Grann, Alison; Minsky, Bruce D.; Cohen, Alfred M.; Saltz, Leonard; Kelsen, David P.; Kemeny, Nancy; Ilson, David; Guillem, Jose G.; Paty, Philip B.; Bass, Joanne

1996-01-01

PURPOSE: We report the downstaging, acute toxicity, and preliminary local control and survival of pre-op 5-FU, low dose LV, and concurrent RT followed by post-op LV/5-FU for pts with clinically resectable, T3 rectal cancer. MATERIALS AND METHODS: A total of 32 pts (M:26, F:6) were prospectively treated from 12/91-8/95. Eligibility criteria included adequate hematologic indicies, primary adenocarcinoma limited to the pelvis, and T3 disease confirmed by transrectal ultrasound. Twenty five pts were considered clinically to require an APR on initial (pre-treatment) assessment by their operating surgeon. The median age was 56 (range: 24-80), and the median distance from the anal verge was 5.0cm (range: 3-9cm). Pts received 2 monthly cycles (bolus daily X 5) of LV (20mg/m2) and 5-FU (325mg/m2), beginning concurrently with day 1 of RT, followed by surgery 4-5 weeks later. RT included 4680 cGy to the pelvis followed by a boost to 5040 cGy. Post-operatively, pts received a median of 2 monthly cycles (range: 0-10 cycles) of LV (20 mg/m2) and 5-FU (425mg/m2). A toxicity assessment was performed at each visit using the NCI toxicity criteria modified for gastrointestinal toxicity. The median follow-up was 12 months (range: 3-48 months). All 32 patients were included in the analysis of toxicity, sphincter preservation, and downstaging. Analysis of patterns of failure and survival was limited to the 15 pts who had a minimum follow-up of 1yr or developed failure prior to 1 yr. For this subset the median follow-up was 24 months (range: 3-48 months). RESULTS: During the pre-op segment, individual grade 3+ acute toxicities were; diarrhea: 16%, bowel movements: 16%, leukopenia: 12%. The incidence of total toxicity was 25% ((8(32))). The median nadir counts were; WBC: 2.9 (range: 1.7-5.6), HGB: 12.4 (range: 7.1-15.0), and PLT (X1000): 161 (range: 113-237). The pathologic complete response rate was 9% ((3(32))). An additional 13% ((4(32))) had negative lymph nodes and 1-2 microscopic

Design and measurement of a TE{sub 13} input converter for high order mode gyrotron travelling wave amplifiers

Energy Technology Data Exchange (ETDEWEB)

Wang, Yan; Liu, Guo, E-mail: liuguo@uestc.edu.cn; Shu, Guoxiang; Yan, Ran; Wang, Li; Agurgo Balfour, E.; Fu, Hao; Luo, Yong [School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); Wang, Shafei, E-mail: rockingsandstorm@163.com [North Electronic Device Research Institution, Box 947, Beijing 100141 (China)

2016-03-15

A technique to launch a circular TE{sub 13} mode to interact with the helical electron beam of a gyrotron travelling wave amplifier is proposed and verified by simulation and cold test in this paper. The high order (HOM) TE{sub 13} mode is excited by a broadband Y-type power divider with the aid of a cylindrical waveguide system. Using grooves and convex strips loaded at the lateral planes of the output cylindrical waveguide, the electric fields of the potential competing TE{sub 32} and TE{sub 71} modes are suppressed to allow the transmission of the dominant TE{sub 13} mode. The converter performance for different structural dimensions of grooves and convex strips is studied in detail and excellent results have been achieved. Simulation predicts that the average transmission is ∼−1.8 dB with a 3 dB bandwidth of 7.2 GHz (91.5–98.7 GHz) and port reflection is less than −15 dB. The conversion efficiency to the TE{sub 32} and TE{sub 71} modes are, respectively, under −15 dB and −24 dB in the operating frequency band. Such an HOM converter operating at W-band has been fabricated and cold tested with the radiation boundary. Measurement from the vector network analyzer cold test and microwave simulations show a good reflection performance for the converter.

Tunable driver for the LLNL FEL experiment

International Nuclear Information System (INIS)

Guss, W.C.; Basten, M.A.; Kreischer, K.E.; Temkin, R.J.

1991-07-01

This report describes main activities undertaken during the period 1 June 1990 to 1 June 1991 by MIT to support the Lawrence Livermore National Laboratory tunable FEL driver project. The goal of this research was to further characterize a tunable microwave source (already identified as a BWO-gyrotron) of moderate output power (10--20 kW). In the 1989 fiscal year, the source was assembled at MIT and initial tests were conducted. Proposed for the fiscal year 1990 were analysis of the previous experimental results, and the performance of new experiments designed to increase the voltage tuning range, the output efficiency, and magnetic field tuning. During the report period the previous experimental results were analyzed and compared to computational results and new components were designed, to make the BWO ready for further experiments. In addition, the BWO-gyrotron was mounted in a new superconducting magnet and initial magnetic field profile measurements were made

A Reactor Development Scenario for the FuZE Sheared-Flow Stabilized Z-pinch

Science.gov (United States)

McLean, Harry S.; Higginson, D. P.; Schmidt, A.; Tummel, K. K.; Shumlak, U.; Nelson, B. A.; Claveau, E. L.; Forbes, E. G.; Golingo, R. P.; Stepanov, A. D.; Weber, T. R.; Zhang, Y.

2017-10-01

We present a conceptual design, scaling calculations, and development path for a pulsed fusion reactor based on a flow-stabilized Z-pinch. Experiments performed on the ZaP and ZaP-HD devices have largely demonstrated the basic physics of sheared-flow stabilization at pinch currents up to 100 kA. Initial experiments on the FuZE device, a high-power upgrade of ZaP, have achieved 20 usec of stability at pinch current 100-200 kA and pinch diameter few mm for a pinch length of 50 cm. Scaling calculations based on a quasi-steady-state power balance show that extending stable duration to 100 usec at a pinch current of 1.5 MA and pinch length of 50 cm, results in a reactor plant Q 5. Future performance milestones are proposed for pinch currents of: 300 kA, where Te and Ti are calculated to exceed 1-2 keV; 700 kA, where DT fusion power would be expected to exceed pinch input power; and 1 MA, where fusion energy per pulse exceeds input energy per pulse. This work funded by USDOE ARPA-E and performed under the auspices of Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. LLNL-ABS-734770.

The DIII-D 3 MW, 110 GHz ECH System

International Nuclear Information System (INIS)

Callis, R.W.; Lohr, J.; Ponce, D.; O'Neill, R.C.; Prater, R.; Luce, T.C.

1999-01-01

Three 110 GHz gyrotrons with nominal output power of 1 MW each have been installed and are operational on the DIII-D tokamak. One gyrotron is built by Gycom and has a nominal rating of 1 MW and a 2 s pulse length, with the pulse length being determined by the maximum temperature allowed on the edge cooled Boron Nitride window. The second and third gyrotrons were built by Communications and Power Industries (CPI). The first CPI gyrotron uses a double disc FC-75 cooled sapphire window which has a pulse length rating of 0.8 s at 1 MW, 2s at 0.5 MW and 10s at 0.35 MW. The second CPI gyrotron, utilizes a single disc chemical-vapor-deposition diamond window, that employs water cooling around the edge of the disc. Calculation predict that the diamond window should be capable of full 1 MW cw operation. All gyrotrons are connected to the tokamak by a low-loss-windowless evacuated transmission line using circular corrugated waveguide for propagation in the HEl 1 mode. Each waveguide system incorporates a two mirror launcher which can steer the rf beam poloidally from the center to the outer edge of the plasma. Central current drive experiments with the two gyrotrons with 1.5 MW of injected power drove about 0.17 MA. Results from using the three gyrotron systems will be reported as well as the plans to upgrade the system to 6 MW

Millimetre waves and plasma physics

International Nuclear Information System (INIS)

Brand, G.F.

1999-01-01

Full text: This talk is a review of the plasma-related presentations at the 23rd International Conference on Infrared and Millimeter Waves held at the University of Essex, Colchester, UK 7-11 September 1998. Of most relevance to fusion is the development of high-power sources for electron cyclotron resonance heating and current drive. The requirements for ITER are a total of 50 MW at 170 GHz. The state of the art is illustrated by (a) high-power gyrotrons that deliver 1 MW for 1 s at 170 GHz, and (b) a free-electron maser that has generated millimetre waves for the first time, 730 kW at 200 GHz. A number of papers describe new technologies that allow high powers to be achieved; internal mode converters to convert the whispering-gallery mode generated in the gyrotron cavity into a gaussian beam, depressed collectors to raise the efficiency from 1/3 to better than 1/2, CVD diamond output windows and coaxial gyrotrons with improved mode purity. Other papers describe transmission lines and steerable mirrors. Several papers deal with millimetre-wave plasma diagnostics for fusion such as electron cyclotron emission measurements and reflectometry. (author)

Kung fu training improves physical fitness measures in overweight/obese adolescents: the "martial fitness" study.

Science.gov (United States)

Tsang, Tracey W; Kohn, Michael R; Chow, Chin Moi; Fiatarone Singh, Maria Antoinette

2010-01-01

Aim. To examine the efficacy of a six-month Kung Fu (KF) program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC) control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7 +/- 27.8%. At follow-up, the cohort improved in absolute upper (P = .002) and lower (P = .04) body strength, and upper body muscle endurance (P = .02), without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P = .03), lower body muscle endurance (P = .28; significant 95% CI: 0.37-2.49), and upper body muscle velocity (P = .03) relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness.

Antibacterial Activity of Copper Oxide (CuO Nanoparticles Biosynthesized by Bacillus sp. FU4: Optimization of Experiment Design

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Mojtaba Taran, Maryam Rad, Mehran Alavi

2017-09-01

Full Text Available Background: There are several methods for synthesis of metallic nanoparticles (NPs including chemical, physical and biological process. In this study, Bacillus sp. FU4 was used as biological source for biosynthesis of CuO NPs. Methods: CuO NPs have been prepared by copper sulfate (CuSO4. CuO NPs were formed after oxidation of Cu NPs. Design and analysis of Taguchi experiments (an orthogonal assay and analysis of variance (ANOVA carried out by the Qualitek-4 software. Average effect of CuSO4 concentration (0.1, 0.01 and 0.001 M, incubation and culturing time (48, 72, 96 hours as three controllable factors with three levels were evaluated in CuO NPs biosynthesis. Characterization of CuO NPs was determined by UV-Vis spectroscopy, X-ray diffraction (XRD, Fourier transform infra-red (FT-IR spectroscopy and scanning electron microscopy (SEM. Also, the antimicrobial properties of CuO NPs were investigated using Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 43300 as multidrug resistant (MDR bacteria. Results: Results: It was evaluated that, NPs size distributions were in the range of 2-41 nm with spherical shapes. The anti-bacterial activities of CuO NPs were measured based on diameter of inhibition zone in disk diffusion tests of NPs dispersed in batch cultures. Two levels of CuSO4 concentrations (0.1 and 0.01M had antibacterial effect on E.coli (33±0.57 and 6 ±2mm. In the case of S. aureus, there was surprisingly no sign of growth. Conclusion: CuO NPs have antibacterial activity that can be benefit in medicinal aspect for fighting against prominent pathogen bacteria such as E.coli ATCC 25922 and S.aureus ATCC 43300.

Design and testing of data analysis tool for ECRH systems in labview

International Nuclear Information System (INIS)

Patel, Jatinkumar; Patel, H.; Purohit, D.; Rajanbabu, N.; Mistry, H.; Shukla, B.K.

2017-01-01

Electron Cyclotron Resonance Heating (ECRH) is one of the essential RF heating sub systems used for pre-ionization and current drive experiments in SST1. In SST-1, Gyrotron based two ECRH systems are installed. 42 GHz gyrotron system capable of delivering 500kW RF power for 500ms and the 82.6 GHz gyrotron capable of delivering 200kW continuously for 1000 second. VME based Data acquisition and control (DAC) system is installed with the gyrotron systems and is under operation with SST-1. This paper explains the basic features of PXI DAC and the data analysis tool designed in labview 2014 and the problems faced during design and testing of different lengths of data plot. It has various features of plotting data in different categories i.e. plotting of fast acquisition signals data to decide the sequence of gyrotron interlocks happened during the gyrotron operations, conversion of main binary file into 32 .text files and all the 32 analog signals data plot in a single plot, auto update of selected important signals plot at the end of the shot

Alexander von Humboldt’s Footnotes: “Networks of Knowledge” in the Sources of the 1826 Essai politique sur l’île de Cuba

OpenAIRE

Anja Werner

2014-01-01

Zusammenfassung Alexander von Humboldts Fußnoten waren ihrer Zeit weit voraus, obwohl sie kaum den heutigen akademischen Standards entsprechen. Dieser Artikel untersucht die Fußnoten in Humboldts Essai politique sur l’île de Cuba (1826). Zwar ist es nicht immer leicht, die manchmal recht geheimnisvollen Verweise zu entschlüsseln, dennoch lohnt sich der Versuch: Humboldts Fußnoten geben nicht nur Auskunft über seine umfassenden Netzwerke des Wissens. Sie verweisen auch auf Auseinandersetzu...

Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy

International Nuclear Information System (INIS)

Ishikawa, Masashi; Miyauchi, Takayuki; Kashiwagi, Yutaka

2008-01-01

A number of studies have investigated whether the activity levels of enzymes involved in 5-fluorouracil (5-FU) metabolism are prognostic factors for survival in patients with colorectal carcinoma. Most reports have examined thymidylate synthetase (TS) and dihydropyrimidine dehydrogenase (DPD) in unresectable or metastatic cases, therefore it is unclear whether the activity of these enzymes is of prognostic value in colorectal cancer patients treated with radical resection and adjuvant chemotherapy with 5-FU. This study examined fresh frozen specimens of colorectal carcinoma from 40 patients who had undergone curative operation and were orally administered adjuvant tegafur/uracil (UFT) chemotherapy. TS, DPD and orotate phosphoribosyl transferase (OPRT) activities were assayed in cancer tissue and adjacent normal tissue and their association with clinicopathological variables was investigated. In addition, the relationships between TS, DPD and OPRT activities and patient survival were examined to determine whether any of these enzymes could be useful prognostic factors. While there was no clear relationship between pathological findings and TS or DPD activity, OPRT activity was significantly lower in tumors with lymph node metastasis than in tumors lacking lymph node metastasis. Postoperative survival was significantly better in the groups with low TS activity and/or high OPRT activity. TS and OPRT activity levels in tumor tissue may be important prognostic factors for survival in Dukes' B and C colorectal carcinoma with radical resection and adjuvant chemotherapy with UFT

Gauge-theoretic invariants for topological insulators: a bridge between Berry, Wess-Zumino, and Fu-Kane-Mele

Science.gov (United States)

Monaco, Domenico; Tauber, Clément

2017-07-01

We establish a connection between two recently proposed approaches to the understanding of the geometric origin of the Fu-Kane-Mele invariant FKM\\in Z_2, arising in the context of two-dimensional time-reversal symmetric topological insulators. On the one hand, the Z_2 invariant can be formulated in terms of the Berry connection and the Berry curvature of the Bloch bundle of occupied states over the Brillouin torus. On the other, using techniques from the theory of bundle gerbes, it is possible to provide an expression for FKM containing the square root of the Wess-Zumino amplitude for a certain U( N)-valued field over the Brillouin torus. We link the two formulas by showing directly the equality between the above-mentioned Wess-Zumino amplitude and the Berry phase, as well as between their square roots. An essential tool of independent interest is an equivariant version of the adjoint Polyakov-Wiegmann formula for fields T^2 → U(N), of which we provide a proof employing only basic homotopy theory and circumventing the language of bundle gerbes.

Long-term results of the maxillary sinus carcinoma with irradiation and intraarterial infusion of 5-FU

Energy Technology Data Exchange (ETDEWEB)

Sakaguchi, Masanori; Netsu, Kiminori (Shinshu Univ., Matsumoto, Nagano (Japan). Faculty of Medicine); Kawarada, Kazuo; Yachiyama, Hitoshi

1990-08-01

Therapeutic results of 33 primary cases of maxillary sinus carcinoma treated with irradiation and intraarterial infusion of 5-FU between 1972 and 1984 were analyzed. The 5-year crude survival rate for the group with stage T2 carcinoma (n=10) was 50.0%, and for those with T3 (n=15) and T4 (n=8) it was 46.7% and 25.0%, respectively. The overall 5-year crude survival rate was 42.4%. Eight patients who did not undergo maxillectomy survived for 5 years after irradiation and intraarterial infusion. Recurrence of the tumor after the irradiation and intraarterial infusion occurred in 63.6%, and was frequently observed at the ethmoidal region and the orbita. In the areas in which the tumor extended to regions such as the ethmoid sinus and orbita, which are nourished by arteries other than the maxillary artery, conventional intraarterial infusion was ineffective for complete tumor eradication. Therefore, in most of the patients with advanced maxillary sinus carcinoma, partial or total maxillectomy following combined therapy of intraarterial infusion and irradiation is necessary to improve a prognosis. (author).

Kung Fu Training Improves Physical Fitness Measures in Overweight/Obese Adolescents: The “Martial Fitness” Study

Directory of Open Access Journals (Sweden)

Tracey W. Tsang

2010-01-01

Full Text Available Aim. To examine the efficacy of a six-month Kung Fu (KF program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7±27.8%. At follow-up, the cohort improved in absolute upper (P=.002 and lower (P=.04 body strength, and upper body muscle endurance (P=.02, without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P=.03, lower body muscle endurance (P=.28; significant 95% CI: 0.37–2.49, and upper body muscle velocity (P=.03 relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness.

Long-term results of the maxillary sinus carcinoma with irradiation and intraarterial infusion of 5-FU

International Nuclear Information System (INIS)

Sakaguchi, Masanori; Netsu, Kiminori; Kawarada, Kazuo; Yachiyama, Hitoshi.

1990-01-01

Therapeutic results of 33 primary cases of maxillary sinus carcinoma treated with irradiation and intraarterial infusion of 5-FU between 1972 and 1984 were analyzed. The 5-year crude survival rate for the group with stage T2 carcinoma (n=10) was 50.0%, and for those with T3 (n=15) and T4 (n=8) it was 46.7% and 25.0%, respectively. The overall 5-year crude survival rate was 42.4%. Eight patients who did not undergo maxillectomy survived for 5 years after irradiation and intraarterial infusion. Recurrence of the tumor after the irradiation and intraarterial infusion occurred in 63.6%, and was frequently observed at the ethmoidal region and the orbita. In the areas in which the tumor extended to regions such as the ethmoid sinus and orbita, which are nourished by arteries other than the maxillary artery, conventional intraarterial infusion was ineffective for complete tumor eradication. Therefore, in most of the patients with advanced maxillary sinus carcinoma, partial or total maxillectomy following combined therapy of intraarterial infusion and irradiation is necessary to improve a prognosis. (author)

Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design.

Science.gov (United States)

Andalib, Sare; Varshosaz, Jaleh; Hassanzadeh, Farshid; Sadeghi, Hojjat

2012-01-01

Nanostructured lipid carriers (NLC) are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol), lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of -25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers.

Sequential radiotherapy and chemotherapy using CDDP and 5-FU for advanced head and neck cancer

International Nuclear Information System (INIS)

Takamura, Akio; Arimoto, Takuro; Mizoe, Jun-etsu; Tomita, Masayoshi; Kitahara, Toshihiro; Irie, Goro; Matsuoka, Yoshisuke.

1991-01-01

From April 1989 to January 1990, nine patients with locally advanced stage IV squamous cell carcinoma of the head and neck underwent combined chemotherapy and radiotherapy (RT). Chemotherapy consisted of two cycles of CDDP (100 mg/m 2 , day 1) + 5-FU (1 g/m 2 , days 1-5, continuous infusion) every five weeks. RT was interdigitated with chemotherapy after the second course of chemotherapy. Each course was initiated two or three days after interrupting chemotherapy. RT was delivered at 65 or 70 Gy for 8 weeks. Of the 7 patients completing the treatment, 29% responded totally, and 43% responded partially. Seven patients died: two due to acute treatment-related toxicity; four due to locoregional progression; and one due to an unrelated cause. Two patients are still alive (10 and 12 months); one is free of tumor, the other has a metastatic bone tumor. Though sequential use of CT might be considered effective for some patients, acute toxicity was moderate to severe and patients with poor performance (≤70%), elderly (≥70 yr) and renal dysfunction (creatinine clearance<80 ml/min) patients must be considered as high risk for treatment by our combined regimen. (author)

Large power electron tubes for high frequency heating

International Nuclear Information System (INIS)

Okamoto, Tadashi; Sato, Hisaaki.

1988-01-01

On the large power electron tubes used for electron cyclotron heating, lower hybrid resonance frequency heating, and ion cyclotron range of frequency heating, namely gyrotron, klystron and quadrupole tube, the features, the present status of development, the construction, the principle and so on are explained. The research and development of gyrotrons are most advanced in USSR, the inventor. The course of the development of gyrotrons in foreign countries and in Japan is described. There are many variants of gyrotrons, for example whispering gallery mode, klystron type, backward wave oscillator type, gyro-peniotron and others. The principle of gyrotrons is explained, and about the examples of the developed gyrotrons, the design parameters are shown. For the purpose of using for the LHRF heating in JT-60, a superlarge power klystron of 1 MW output at 2 GHz frequency, which is the largest class in the world, has been developed. Its total length is 2.7 m, and weight is 1.5 t. It features, construction, function and performance are reported. The trend of large power quadrupole tubes is toward stable action with large power in VHF zone, and the typical products in USA and Europe are shown. (Kako, I.)

Development of ECR ion source and LEBT technology for RIA

International Nuclear Information System (INIS)

Leitner, Daniela; Lyneis, Claude M.; Abbott, Steven R.; Dwinell, Roger D.; Leitner, Matthaeus; Silver, Charles S.; Taylor, Clyde E.

2004-01-01

The Rare Isotope Accelerator (RIA) Linac driver requires a great variety of high charge state ion beams with up to a magnitude higher intensity than currently achievable for the heaviest masses. The goal of the RIA injector R and D program for VENUS is the reliable production of intense medium charge state ion beams, e.g., 8 puA (particle mu A) of U29+. Therefore, the superconducting ECR ion source VENUS has been designed from the beginning for optimum operation at 28 GHz at high power (10 kW). In addition, a high intensity Low Energy Beam Transport, LEBT, that was developed to analyze and transport these multiply-charged, space charge dominated beams. During the last year VENUS was commissioned at 18 GHz and preparations for 28 GHz operation continued. Tests with various gases and recently metals have been performed with up to 2000 W of 18 GHz RF power. Promising performance has been measured in those preliminary beam tests. For example, 180 p mu A of O6+, 15 p mu A of Ar12+, 7.5 puA of X e20+ and 4puA of Bi24+ were produced in the early commissioning phase, ranking VENUS among the currently highest performance 18 GHz ECR ion sources. In FY04 a 10 kW 28 gyrotron system will be added, which will enable VENUS to reach full performance. The emittance of the beams produced at 18 GHz was measured with a two axis emittance scanner developed with earlier RIA R and D funds

Maturing ECRF technology for plasma control

International Nuclear Information System (INIS)

Callis, R.W.; .; Cary, W.P.; Chu, S.

2003-01-01

The availability of high power, (∼1 MW) long pulse length (effectively cw), high frequency, (>100 GHz) gyrotrons has opened the opportunity for enhanced scientific results on magnetic confinement devices for fusion research worldwide. This has led to successful experiments on electron cyclotron heating, electron cyclotron current drive, non-inductive tokamak operation, tokamak energy transport, suppression of instabilities and advanced profile control leading to enhanced performance. The key development in the gyrotron community that has led to the realization of high power long pulse gyrotrons is the availability of edge cooled synthetic diamond gyrotron output windows, which have low loss and excellent thermal and mechanical properties. In addition to the emergence of reliable high power gyrotrons, ancillary equipment for efficient microwave transmission over distances of hundreds of meters, polarization control, diagnostics, and flexible launch geometry have all been developed and proven in regular service. (author)

High-power corrugates waveguide components for mm-wave fusion heating systems

International Nuclear Information System (INIS)

Olstad, R.A.; Doane, J.L.; Moeller, C.P.; O'Neill, R.C.; Di Martino, M.

1996-10-01

Considerable progress has been made over the last year in the U.S., Japan, Russia, and Europe in developing high power long pulse gyrotrons for fusion plasma heating and current drive. These advanced gyrotrons typically operate at a frequency in the range 82 GHz to 170 GHz at nearly megawatt power levels for pulse lengths up to 5 s. To take advantage of these new microwave sources for fusion research, new and improved transmission line components are needed to reliably transmit microwave power to plasmas with minimal losses. Over the last year, General Atomics and collaborating companies (Spinner GmbH in Europe and Toshiba Corporation in Japan) have developed a wide variety of new components which meet the demanding power, pulse length, frequency, and vacuum requirements for effective utilization of the new generation of gyrotrons. These components include low-loss straight corrugated waveguides, miter bends, miter bend polarizers, power monitors, waveguide bellows, de breaks, waveguide switches, dummy loads, and distributed windows. These components have been developed with several different waveguide diameters (32, 64, and 89 mm) and frequency ranges (82 GHz to 170 GHz). This paper describes the design requirements of selected components and their calculated and measured performance characteristics

2 MW 110 GHz ECH heating system for DIII-D

International Nuclear Information System (INIS)

Moeller, C.; Prater, R.; Callis, R.; Remsen, D.; Doane, J.; Cary, W.; Phelps, R.; Tupper, M.

1990-09-01

A 2 MW 110 GHz ECH system using Varian 0.5 MW gyrotrons is under construction for use on the DIII-D tokamak by late 1991. Most of the components are being design and fabricated at General Atomics, including the gyrotron tanks, superconducting magnets, and transmission line. These components are intended for operation with 10 second pulses and, in the future, with 1 MW gyrotrons. 6 refs., 5 figs

Long-term outcomes of trimodality treatment for squamous cell carcinoma of the esophagus with cisplatin and/or 5-FU. More than 20 years' experience at a single institution

Energy Technology Data Exchange (ETDEWEB)

Fakhrian, Khashayar [Ruhr-Universitaet Bochum, Department of Radiation Oncology, Marien Hospital Herne and Sankt Josef Hospital Bochum, Bochum (Germany); Technische Universitaet Muenchen, Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Universitaetsklinikum der Ruhr-Universitaet Bochum, Klinik fuer Strahlentherapie und Radio-Onkologie, Marienhospital Herne, Herne (Germany); Ordu, Arif Deniz; Molls, Michael [Technische Universitaet Muenchen, Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Lordick, Florian [University Clinic Leipzig, University Cancer Center Leipzig (UCCL), Leipzig (Germany); Technische Universitaet Muenchen, Department of Internal Medicine III (Hematology/Oncology), Munich (Germany); Theisen, Joerg [Technische Universitaet Muenchen, Department of Surgery, Klinikum rechts der Isar, Munich (Germany); Haller, Bernhard [Technische Universitaet Muenchen, Institute for Medical Statistics and Epidemiology, Klinikum rechts der Isar, Munich (Germany); Omrcen, Tomislav [Technische Universitaet Muenchen, Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); University Hospital Split, Center of Oncology and Radiotherapy, Split (Croatia); Nieder, Carsten [Department of Oncology and Palliative Medicine, Nordland Hospital Trust, Bodoe (Norway); University of Tromsoe, Institute of Clinical Medicine, Faculty of Health Sciences, Tromsoe (Norway); Geinitz, Hans [Technische Universitaet Muenchen, Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Krankenhaus der Barmherzigen Schwestern Linz, Department of Radiation Oncology, Linz (Austria)

2014-12-15

The purpose of this article is to report the outcome of neoadjuvant radiochemotherapy (N-RCT) + surgery in patients with squamous cell carcinoma of the esophagus at a single institution. We retrospectively reviewed data from patients who were referred to our department for N-RCT. From 1988-2011, 103 patients were treated with N-RCT with cisplatin and/or 5-fluorouracil (5-FU). Group 1: (n = 55) from 1988-2006 with 39.6-40 Gy and 5-FU with (n = 17) or without cisplatin (n = 38). Group 2: from 2003-2010 with 44-45 Gy and 5-FU with (n = 40) or without cisplatin (n = 8). All patients underwent radical resection with reconstruction according to tumor location and 2-field lymph node dissection. The degree of histomorphologic regression was defined as grade 1a (pCR, 0 % residual tumor), grade 1b (pSTR, < 10 % residual tumor), grade 2 (10-50 % residual tumor), and grade 3 (> 50 % residual tumor). Median follow-up time from the start of N-RCT was 100 months (range 2-213 months). The median overall survival (OS) for the whole cohort was 42 months and the 5-year OS was 45 ± 5 %. In the multivariate analysis, worse ECOG performance status (p < 0.001), weight loss > 10 % before the start of the N-RCT (p = 0.025), higher pT category (p = 0.001), and grade 2/3 pathologic remission (p < 0.001) were significantly associated with a poor OS. PCR and pSTR rates for group 1 were 36 % and 18 % compared to 53 % and 22 % for group 2 (p = 0.011). There was a tendency for a better outcome in group 2 patients without statistical significance. The 5-year OS, disease-free survival and recurrent-free survival were 36 ± 7 %, 35 ± 6, and 36 ± 7 % for group 1 and 55 ± 7, 49 ± 7, and 53 ± 7 in group 2 (p = 0.117, p = 0.124, and p = 0.087). There was no significant difference between the two groups considering the postoperative morbidity and mortality. Higher radiation doses and more use of simultaneous cisplatin lead to higher pathologic response rates to N-RCT and may be associated with

Technical note: Fu-Liou-Gu and Corti-Peter model performance evaluation for radiative retrievals from cirrus clouds

Science.gov (United States)

Lolli, Simone; Campbell, James R.; Lewis, Jasper R.; Gu, Yu; Welton, Ellsworth J.

2017-06-01

We compare, for the first time, the performance of a simplified atmospheric radiative transfer algorithm package, the Corti-Peter (CP) model, versus the more complex Fu-Liou-Gu (FLG) model, for resolving top-of-the-atmosphere radiative forcing characteristics from single-layer cirrus clouds obtained from the NASA Micro-Pulse Lidar Network database in 2010 and 2011 at Singapore and in Greenbelt, Maryland, USA, in 2012. Specifically, CP simplifies calculation of both clear-sky longwave and shortwave radiation through regression analysis applied to radiative calculations, which contributes significantly to differences between the two. The results of the intercomparison show that differences in annual net top-of-the-atmosphere (TOA) cloud radiative forcing can reach 65 %. This is particularly true when land surface temperatures are warmer than 288 K, where the CP regression analysis becomes less accurate. CP proves useful for first-order estimates of TOA cirrus cloud forcing, but may not be suitable for quantitative accuracy, including the absolute sign of cirrus cloud daytime TOA forcing that can readily oscillate around zero globally.

A randomized phase II study of weekly nab-paclitaxel plus gemcitabine or simplified LV5FU2 as first-line therapy in patients with metastatic pancreatic cancer: the AFUGEM GERCOR trial.

Science.gov (United States)

Bachet, Jean-Baptiste; Chibaudel, Benoist; Bonnetain, Franck; Validire, Pierre; Hammel, Pascal; André, Thierry; Louvet, Christophe

2015-10-06

Metastatic pancreatic adenocarcinoma (PAC) prognosis remains dismal and gemcitabine monotherapy has been the standard treatment over the last decade. Currently, two first-line regimens are used in this setting: FOLFIRINOX and nab-paclitaxel plus gemcitabine. Increasing translational data on the predictive value of hENT1 for determining gemcitabine efficacy suggest that a non-gemcitabine-based regimen is favored in about 60 % of patients with PAC due to high resistance of PAC to this cytotoxic drug. This study aims to evaluate the efficacy of weekly nab-paclitaxel combined with gemcitabine or a simplified (s) LV5FU2 regimen in patients with previously untreated metastatic PAC. AFUGEM is a two-stage, open-label, randomized, multicenter, phase II trial. Patients with PAC who meet the inclusion criteria and provide written informed consent will be randomized in a 1:2 ratio to either nab-paclitaxel (125 mg/m(2)) plus gemcitabine (1000 mg/m(2)) given on days 1, 8, and 15 every 28 days or nab-paclitaxel (125 mg/m(2)) plus sLV5FU2 (leucovorin 400 mg/m(2) followed by bolus 400 mg/m(2) 5-fluorouracil and by 5-fluorouracil 2400 mg/m(2) as an 46-h intravenous infusion) given on days 1 and 15 every 28 days. A total of 114 patients will be randomized to one of the treatment arms. The primary endpoint is progression-free survival at 4 months. Secondary outcomes are rate and duration of response, disease control, overall survival, safety, and quality of life. Potential biomarkers of gemcitabine (hENT1, dCK) and 5-fluorouracil (TS) efficacy will be assessed. The AFUGEM trial is designed to provide valuable information regarding efficacy and tolerability of nab-paclitaxel plus gemcitabine and nab-paclitaxel plus sLV5FU2 regimens. Identification of potential predictive biomarkers of gemcitabine and 5-fluorouracil is likely to drive therapeutic decisions in patients with metastatic PAC. AFUGEM is registered at Clinicaltrials.gov: NCT01964534 , October 15, 2013.

Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design

Directory of Open Access Journals (Sweden)

Sare Andalib

2012-01-01

Full Text Available Background: Nanostructured lipid carriers (NLC are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. Materials and Methods: The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol, lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. Results: The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of −25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. Conclusions: The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers.

Molecular analysis of Ixodes rugicollis, Candidatus Neoehrlichia sp. (FU98) and a novel Babesia genotype from a European badger (Meles meles).

Science.gov (United States)

Hornok, Sándor; Trauttwein, Klaudia; Takács, Nóra; Hodžić, Adnan; Duscher, Georg Gerhard; Kontschán, Jenő

2017-01-01

The European badger (Meles meles) is a widespread mammal in most countries of the European continent, with increasingly recognized veterinary/medical importance owing to its preferred habitats (including pastures and urban environments), broad spectrum of food items, and role as a game hunting target. However, ticks and tick-borne pathogens associated with badgers are only partly known, and most of them have not yet been analysed with molecular biological methods The aim of this study was to perform molecular taxonomic analysis of ticks collected from a road-killed European badger, as well as to molecularly investigate its ticks and blood sample for the presence of Anaplasmataceae and piroplasms. Ticks from the badger were morphologically identified as females of Ixodes rugicollis. Based on its cytochrome oxidase subunit I (COI) and 16S rRNA sequences, I. rugicollis phylogenetically clustered together with I. lividus and I. arboricola, i.e. other members of the subgenus Pholeoixodes. The blood sample of the badger contained the DNA of Candidatus Neoehrlichia sp. (FU98) recently identified in red fox in Austria and the Czech Republic. This genotype is most closely related to Ca. N. lotoris (from raccoons in North America), and has lower sequence identity with the I. ricinus-transmitted zoonotic agent, Ca. N. mikurensis found in Eurasia. In the blood of the badger and in one female I. rugicollis, the DNA of a new Babesia genotype was also present, which differed from a piroplasm detected in M. meles in Spain, and clustered phylogenetically in the B. microti clade. Phylogenetic analysis of I. rugicollis (based on two genetic markers) confirms its status in subgenus Pholeoixodes. Ca. Neoehrlichia sp. (FU98) was identified for the first time in M. meles and in Hungary. In addition, a molecularly previously not yet characterized Babesia genotype occurs in badgers in Central Europe. Copyright © 2016 Elsevier GmbH. All rights reserved.

The Experimental Verification of Gaussian Beam Coupling for ECH Transmission Line at 400 GHz

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Choe Mun Seok

2017-01-01

Full Text Available We design a quasi-optical transmission line system for a 400 GHz gyrotron beam. The 400GHz Gaussian beam is injected to a corrugated waveguide bounced from a quasi-optical mirror. From detailed 2D field patterns of the output beam emitted from the corrugated waveguide, we analyze the mode contents and the source of non-ideal beam expansion

O "Kung Fu" no Brasil na perspectiva dos mestres pioneiros: problemas e perspectivas no uso da história oral como instrumental de análise

Directory of Open Access Journals (Sweden)

Fernando Dandoro Castilho FERREIRA

2014-03-01

Full Text Available Objetivando analisar a disseminação das artes marciais chinesas no Brasil optamos por entrevistar mestres pioneiros que imigraram da China trazendo na bagagem o "Kung Fu". Ao fazer esta opção em nossa dissertação, tomamos contato com um instrumental que é o uso de entrevistas na perspectiva da História Oral. Remexer a memória, aceitar os silêncios, respeitar o conhecimento construído e desconstruir outros, por si só já se mostram tarefas bastante árduas. Escutar estes mestres nos levou, mesmo que superficialmente, a tentar compreender aspectos da cultura chinesa sob os quais os mestres e o próprio "Kung Fu" se fundamentaram. Entender as lacunas, as dificuldades e as possibilidades do uso da História Oral como ferramenta metodológica é o que neste artigo buscamos, na perspectiva de contribuir com análises semelhantes, seja de outras práticas marciais ou mesmo de outros olhares sobre a cultura chinesa. Assim sendo, objetivamos neste artigo apontar e discutir a metodologia da História Oral e sua pertinência para o estudo das práticas marciais a partir do uso de entrevistas. Podemos, fruto da discussão apresentada, apontar a História Oral como instrumental bastante útil para a discussão das práticas marciais, considerando logicamente, as pertinências e especificidades necessárias para a adequada utilização desta metodologia de pesquisa.

A randomized controlled trial of Kung Fu training for metabolic health in overweight/obese adolescents: the "martial fitness" study.

Science.gov (United States)

Tsang, Tracey W; Kohn, Michael; Chow, Chin Moi; Singh, Maria Fiatarone

2009-07-01

Twenty overweight/obese adolescents underwent six months of Kung Fu or placebo (Tai Chi) training, 3x.wk(-1). Outcomes included fasting insulin and insulin resistance, lipids, glucose and HbA(1c), and C-reactive protein (CRP). CRP decreased significantly (p = 0.03) in both groups over time at six months. Although insulin sensitivity did not change, HbA(1c) tended to decrease over time (p = 0.09), again with no group difference (p = 0.60). Reduced CRP was related to increased upper body strength (p = 0.01). Increased lean body mass was related to reductions in HbA(1c), insulin resistance, triglycerides, and total cholesterol. Improvements in lean body mass appear to have a potential role in favorable metabolic outcomes, independent of changes in fat mass. Further research in this area is warranted before definite conclusions can be drawn about the efficacy of martial arts training for metabolic outcomes in this cohort.

Annual Progress Report on Contract AFOSR-81-0093, March 15, 1984 to March 14, 1985,

Science.gov (United States)

1985-04-30

pulsar period. A recent development in pulsars was the observation of a pulsar outside our galaxy in the large { ( Magellanic cloud , with a period of 0.9...gyrotrons and other cyclotron masers. A. Goldenberg of the USSR gave a survey paper on gyrotron research in the USSR. He is from the city of Gorky...gas at 1 atmosphere, the purpose of which was not specified. G. L. Granatstein of the Naval Research Laboratory then gave a paper on Gyrotron and other

MFTF-B quasi-optical ECRH transmission system

International Nuclear Information System (INIS)

Yugo, J.J.; Shearer, J.W.; Ziolkowski, R.W.

1983-01-01

The microwave transmission system for ERCH on MFTF-B will utilize quasi-optical transmission techniques. The system consists of ten gyrotron oscillators: two gyrotrons at 28 GHz, two at 35 GHz, and six at 56 GHz. The 28 and 35 GHz gyrotrons both heat the electrons in the end plug (potential peak) while the 56 GHz sources heat the minimum-B anchor region (potential minimum). Microwaves are launched into a pair of cylindrical mirrors that form a pseudo-cavity which directs the microwaves through the plasma numerous times before they are lost out of the cavity. The cavity allows the microwave beam to reach the resonance zone over a wide range of plasma densities and temperatures. The fundamental electron cyclotron resonance moves to higher axial positions as a result of beta-depression of the magnetic field, doppler shifting of the resonance, and relativistic mass corrections for the electrons. With this system the microwave beam will reach the resonance surface at the correct angle of incidence for any density or temperature without active aiming of the antennas. The cavity also allows the beam to make multiple passes through the plasma to increase the heating efficiency at low temperatures and densities when the single pass absorption is low. In addition, neutral beams and diagnostics have an unobstructed view of the plasma

ECH Technology Development

Energy Technology Data Exchange (ETDEWEB)

Temkin, Richard [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

2014-12-24

Electron Cyclotron Heating (ECH) is needed for plasma heating, current drive, plasma stability control, and other applications in fusion energy sciences research. The program of fusion energy sciences supported by U. S. DOE, Office of Science, Fusion Energy Sciences relies on the development of ECH technology to meet the needs of several plasma devices working at the frontier of fusion energy sciences research. The largest operating ECH system in the world is at DIII-D, consisting of six 1 MW, 110 GHz gyrotrons capable of ten second pulsed operation, plus two newer gyrotrons. The ECH Technology Development research program investigated the options for upgrading the DIII-D 110 GHz ECH system. Options included extending present-day 1 MW technology to 1.3 – 1.5 MW power levels or developing an entirely new approach to achieve up to 2 MW of power per gyrotron. The research consisted of theoretical research and designs conducted by Communication and Power Industries of Palo Alto, CA working with MIT. Results of the study would be validated in a later phase by research on short pulse length gyrotrons at MIT and long pulse / cw gyrotrons in industry. This research follows a highly successful program of development that has led to the highly reliable, six megawatt ECH system at the DIII-D tokamak. Eventually, gyrotrons at the 1.5 megawatt to multi-megawatt power level will be needed for heating and current drive in large scale plasmas including ITER and DEMO.

Physiological, performance, and nutritional profile of the Brazilian Olympic Wushu (kung-fu) team.

Science.gov (United States)

Artioli, Guilherme Giannini; Gualano, Bruno; Franchini, Emerson; Batista, Rafael Novaes; Polacow, Viviane Ozores; Lancha, Antonio Herbert

2009-01-01

The purpose of the present study was to determine physiological, nutritional, and performance profiles of elite Olympic Wushu (kung-fu) athletes. Ten men and four women elite athletes took part in the study. They completed the following tests: body composition, nutritional assessment, upper-body Wingate Test, vertical jump, lumbar isometric strength, and flexibility. Blood lactate was determined at rest and after the Wingate Test. Blood lactate was also determined during a training session (combat and Taolu training). We found low body fat (men: 9.5 +/- 6.3%; women: 18.0 +/- 4.8%), high flexibility (sit-and-reach-men: 45.5 +/- 6.1 cm; women: 44.0 +/- 6.3 cm), high leg power (vertical jump-men: 37.7 +/- 8.4 cm; women: 32.3 +/- 1.1 cm), high lumbar isometric strength (men: 159 +/- 13 cm; women: 94 +/- 6 cm), moderate arm mean and peak power (Wingate Test-men: 4.1 +/- 0.4 and 5.8 +/- 0.5 Wxkg, respectively; women: 2.5 +/- 0.3 and 3.4 +/- 0.3 W.kg, respectively), and elevated blood lactate after the Wingate Test (men: 10.8 +/- 2.0 mmolxL; women: 10.2 +/- 2.0 mmolxL) and during training (combat: 12.0 +/- 1.8 mmolxL; Taolu: 7.7 +/- 3.3 mmolxL). Men athletes consume a high-fat, low-carbohydrate diet, whereas women consume a moderate, high-carbohydrate diet. Energy consumption was markedly variable. In conclusion, Olympic Wushu seems to be a highly anaerobic-dependent combat sport. Low body fat, high flexibility, leg anaerobic power, isometric strength, and moderately high arm anaerobic power seem to be important for successful competitive performance.

PXIe based data acquisition and control system for ECRH systems on SST-1 and Aditya tokamak

Energy Technology Data Exchange (ETDEWEB)

Patel, Jatinkumar J., E-mail: jatin@ipr.res.in [Institute for Plasma Research, Bhat, Gandhinagar (India); Shukla, B.K.; Rajanbabu, N.; Patel, H.; Dhorajiya, P.; Purohit, D. [Institute for Plasma Research, Bhat, Gandhinagar (India); Mankadiya, K. [Optimized Solutions Pvt. Ltd (India)

2016-11-15

Highlights: • Data Aquisition and control system (DAQ). • PXIe hardware–(PXI–PCI bus extension for Instrumention Express). • RHVPS–Regulated High Voltage Power supply. • SST1–Steady state superconducting tokamak. - Abstract: In Steady State Superconducting (SST-1) tokamak, various RF heating sub-systems are used for plasma heating experiments. In SST-1, Two Electron Cyclotron Resonance Heating (ECRH) systems have been installed for pre-ionization, heating and current drive experiments. The 42 GHz gyrotron based ECRH system is installed and in operation with SST-1 plasma experiments. The 82.6 GHz gyrotron delivers 200 kW CW power (1000 s) while the 42 GHz gyrotron delivers 500 kW power for 500 ms duration. Each gyrotron system consists of various auxiliary power supplies, the crowbar unit and the water cooling system. The PXIe (PCI bus extension for Instrumentation Express)bus based DAC (Data Acquisition and Control) system has been designed, developed and under implementation for safe and reliable operation of the gyrotron. The Control and Monitoring Software applications have been developed using NI LabView 2014 software with real time support on windows platform.

PXIe based data acquisition and control system for ECRH systems on SST-1 and Aditya tokamak

International Nuclear Information System (INIS)

Patel, Jatinkumar J.; Shukla, B.K.; Rajanbabu, N.; Patel, H.; Dhorajiya, P.; Purohit, D.; Mankadiya, K.

2016-01-01

Highlights: • Data Aquisition and control system (DAQ). • PXIe hardware–(PXI–PCI bus extension for Instrumention Express). • RHVPS–Regulated High Voltage Power supply. • SST1–Steady state superconducting tokamak. - Abstract: In Steady State Superconducting (SST-1) tokamak, various RF heating sub-systems are used for plasma heating experiments. In SST-1, Two Electron Cyclotron Resonance Heating (ECRH) systems have been installed for pre-ionization, heating and current drive experiments. The 42 GHz gyrotron based ECRH system is installed and in operation with SST-1 plasma experiments. The 82.6 GHz gyrotron delivers 200 kW CW power (1000 s) while the 42 GHz gyrotron delivers 500 kW power for 500 ms duration. Each gyrotron system consists of various auxiliary power supplies, the crowbar unit and the water cooling system. The PXIe (PCI bus extension for Instrumentation Express)bus based DAC (Data Acquisition and Control) system has been designed, developed and under implementation for safe and reliable operation of the gyrotron. The Control and Monitoring Software applications have been developed using NI LabView 2014 software with real time support on windows platform.

Tempo de jejuar e resistir: a presença do kung-fu no treinamento do ator : a experiência extracotidiana no teatro vocacional em proposição épica

OpenAIRE

Oliveira, Juliana Rocha de [UNESP

2010-01-01

Esta pesquisa surgiu da necessidade de registrar, organizar, sistematizar e relacionar os conhecimentos adquiridos em minha formação de atriz, professora de teatro e artista marcial, no intuito de melhor explorar o processo de criação teatral, utilizando técnicas marciais orientais. Aproximando as duas artes: teatral e marcial – kung fu, termo que além de designar uma arte marcial de origem chinesa possui outros significados como, por exemplo, capacidade de aguentar jejum e resistir, vislumbr...

High-power microwave transmission and launching systems for fusion plasma heating systems

International Nuclear Information System (INIS)

Bigelow, T.S.

1989-01-01

Microwave power in the 30- to 300-GHz frequency range is becoming widely used for heating of plasma in present-day fusion energy magnetic confinement experiments. Microwave power is effective in ionizing plasma and heating electrons through the electron cyclotron heating (ECH) process. Since the power is absorbed in regions of the magnetic field where resonance occurs and launching antennas with narrow beam widths are possible, power deposition location can be highly controlled. This is important for maximizing the power utilization efficiency and improving plasma parameters. Development of the gyrotron oscillator tube has advanced in recent years so that a 1-MW continuous-wave, 140-GHz power source will soon be available. Gyrotron output power is typically in a circular waveguide propagating a circular electric mode (such as TE 0,2 ) or a whispering-gallery mode (such as TE 15,2 ), depending on frequency and power level. An alternative high-power microwave source currently under development is the free-electron laser (FEL), which may be capable of generating 2-10 MW of average power at frequencies of up to 500 GHz. The FEL has a rectangular output waveguide carrying the TE 0,1 mode. Because of its higher complexity and cost, the high-average-power FEL is not yet as extensively developed as the gyrotron. In this paper, several types of operating ECH transmission systems are discussed, as well systems currently being developed. The trend in this area is toward higher power and frequency due to the improvements in plasma density and temperature possible. Every system requires a variety of components, such as mode converters, waveguide bends, launchers, and directional couplers. Some of these components are discussed here, along with ongoing work to improve their performance. 8 refs

«A Ca’ Giustinian fu tutto diverso». La mostra di Paolo Veronese a Venezia (1939 / «A Ca’ Giustinian fu tutto diverso» (At Ca’ Giustiniani eveything was different. Paolo Veronese exhibition in Venice (1939

Directory of Open Access Journals (Sweden)

Matilde Cartolari

2016-12-01

Full Text Available La mostra di Paolo Veronese si svolse a Venezia nel 1939 sotto la direzione di Rodolfo Pallucchini. Promuovendo una ricognizione materiale e critica dell’opera del maestro, la mostra fu l’occasione per effettuare una massiccia campagna di restauri ad opera del bergamasco Mauro Pellicioli e della sua squadra di collaboratori. Agendo sul duplice fronte della museografia e del restauro, Pallucchini si pose in dialogo con le parallele definizioni elaborate in sede istituzionale da Guglielmo Pacchioni e Giulio Carlo Argan. Il presente saggio intende offrire, attraverso materiale archivistico inedito, un’analisi del ruolo della mostra di Veronese nel contesto nazionale e internazionale, ricostruendo con un approccio interdisciplinare le dinamiche teoriche e operative che ne animarono lo svolgimento. Veronese exhibition took place in Venice in 1939 under the direction of Rodolfo Pallucchini. While promoting both material and critical examination of Veronese’s work, the exhibition was an opportunity to undertake a massive restoration, performed by Mauro Pellicioli and his team of collaborators. Pallucchini’s museographical and conservative program was in close relation with the theories promoted by Guglielmo Pacchioni and Giulio Carlo Argan in public administration. This paper intends to offer, through unpublished archival evidence, a detailed analysis of Veronese exhibition in relation to national and international context, in order to understand with an interdisciplinary approach both its theoretical and practical aspects.

Superconducting ECR ion source: From 24-28 GHz SECRAL to 45 GHz fourth generation ECR

Science.gov (United States)

Zhao, H. W.; Sun, L. T.; Guo, J. W.; Zhang, W. H.; Lu, W.; Wu, W.; Wu, B. M.; Sabbi, G.; Juchno, M.; Hafalia, A.; Ravaioli, E.; Xie, D. Z.

2018-05-01

The development of superconducting ECR source with higher magnetic fields and higher microwave frequency is the most straight forward path to achieve higher beam intensity and higher charge state performance. SECRAL, a superconducting third generation ECR ion source, is designed for 24-28 GHz microwave frequency operation with an innovative magnet configuration of sextupole coils located outside the three solenoids. SECRAL at 24 GHz has already produced a number of record beam intensities, such as 40Ar12+ 1.4 emA, 129Xe26+ 1.1 emA, 129Xe30+ 0.36 emA, and 209Bi31+ 0.68 emA. SECRAL-II, an upgraded version of SECRAL, was built successfully in less than 3 years and has recently been commissioned at full power of a 28 GHz gyrotron and three-frequency heating (28 + 45 + 18 GHz). New record beam intensities for highly charged ion production have been achieved, such as 620 eμA 40Ar16+, 15 eμA 40Ar18+, 146 eμA 86Kr28+, 0.5 eμA 86Kr33+, 53 eμA 129Xe38+, and 17 eμA 129Xe42+. Recent beam test results at SECRAL and SECRAL II have demonstrated that the production of more intense highly charged heavy ion beams needs higher microwave power and higher frequency, as the scaling law predicted. A 45 GHz superconducting ECR ion source FECR (a first fourth generation ECR ion source) is being built at IMP. FECR will be the world's first Nb3Sn superconducting-magnet-based ECR ion source with 6.5 T axial mirror field, 3.5 T sextupole field on the plasma chamber inner wall, and 20 kW at a 45 GHz microwave coupling system. This paper will focus on SECRAL performance studies at 24-28 GHz and technical design of 45 GHz FECR, which demonstrates a technical path for highly charged ion beam production from 24 to 28 GHz SECRAL to 45 GHz FECR.

Microwave Power Beaming Infrastructure for Manned Lightcraft Operations: Part 2

International Nuclear Information System (INIS)

Myrabo, Leik N.

2008-01-01

In the past ∼7 years, microwave gyrotron technology has rapidly evolved to a critical threshold wherein ultra-energetic space launch missions based on beamed energy propulsion (BEP) now appear eminently feasible. Over the next 20 years, hundred megawatt-class microwave power-beaming stations could be prototyped on high deserts and 3- to 4 km mountain peaks before migrating into low Earth orbit, along with their passive microwave relay satellites. Described herein is a 20 GW rechargeable nuclear power satellite and microwave power-beaming infrastructure designed for manned space launch operations in the year 2025. The technological readiness of 2500 GJ superconducting magnetic energy storage 'batteries', 433-m ultralight space structures, 100 MW liquid droplet radiators, 1-6+ MW gyrotron sources, and mega-scale arrays (e.g., 3000 phase-locked units) is addressed. Microwave BEP is 'breakthrough' technology with the very real potential to radically reduce space access costs by factors of 100 to 1000 in the forseeable future

XML Schema of PaGE-OM: fuge.xsd [

Lifescience Database Archive (English)

Full Text Available ://www.omg.org/spec/PAGE-OM/20090722/snp schemaLocation=snp.xsd/> ..._source type=fuge:Ontology_source/> _source> ...ogy_term/> _term> Ontology term, defined in more detail in FuGE (http://fuge.sourceforge.net/). This

Development and contribution of rf heating and current drive systems to long pulse, high performance experiments in JT-60U

International Nuclear Information System (INIS)

Moriyama, Shinichi; Seki, Masami; Terakado, Masayuki; Shimono, Mitsugu; Ide, Shunsuke; Isayama, Akihiko; Suzuki, Takahiro; Fujii, Tsuneyuki

2005-01-01

To contribute to high performance long pulse (∼65 s) experiments in JT-60U, the target of the electron cyclotron (EC) operation in long pulse is 0.6 MW for 30 s with four gyrotrons, though 10 MJ (2.8 MW and 3.6 s) was achieved in high power operation before 2003. One of the critical issues for the long pulse operation is detuning due to decay in beam current of the gyrotron. This decay comes from the cathode cooling by continuous electron emission. As a countermeasure for this issue, active adjustments for the heater current and anode voltage during the pulse have successfully extended the duration of a good oscillation condition for the gyrotron. As a result, 0.4 MW for 16 s with one gyrotron to the dummy load and for 8.7 s to the plasma have been achieved up to now

I Am the Invincible Sword Goddess: Mediatization of Chinese Gender Ideology through Female Kung-Fu Practitioners in Films

Directory of Open Access Journals (Sweden)

Mie Hiramoto

2014-09-01

Full Text Available The media are avid portrayers of gender binarism and the belief in male-female distinctions, which are mainly attributed to perceived differences of a physical nature. In this paper, we investigate representations of female kung-fu practitioners (nuxia in films to discuss how processes of mediation and mediatization depict their femininity, so as to mitigate their appropriation of Chinese martial arts masculinity. Often, nuxias are portrayed as empowered women who are equipped to take control of their own lives and to courageously take on challenges from a variety of opponents. However, multimodal deconstruction of the various characteristics of nuxias must be placed in an Asian-specific context in order to understand the femininity specific to these characters and to move beyond Western gender ideologies displayed by the media. Perpetuating Confucian patriarchal ideals, nuxia roles constantly and consistently associate conformation to Confucian values with virtuousness and non-conformation with wickedness. We therefore can use the ideals of Confucianism as a more accurate foundation in deconstructing the identities of nuxias, which allows us to better understand the mediation and mediatization processes of ideologies associated with Chinese femininity and masculinity in martial arts films.

ELECTROMYOGRAPHIC STUDY OF A SEQUENCE OF YAU-MAN KUNG FU PALM STRIKES WITH AND WITHOUT IMPACT

Directory of Open Access Journals (Sweden)

Osmar Pinto Neto

2007-10-01

Full Text Available In martial arts and contact sports, strikes are often trained in two different ways: with and without impacts. This study aims to compare the electromyographical activity (EMG of the triceps brachii (TB, biceps brachii (BB and brachioradialis (BR muscles during strikes with and without impacts. Eight Yau-Man Kung Fu practitioners participated in the experiment. Each participant performed 5 sequences of 5 consecutive KF Yau-Man palm strikes with no impact intercalated with 5 sequences of 5 repetitions targeting a KF training shield. Surface EMG signals were obtained from the TB, BB, and RB for 3.0 seconds using an eight-channel module with a total amplifier gain of 2000 and sampled at 3500 Hz. The EMG analyses were done in the time (rms and frequency (wavelet domains. For the frequency domain, Morlet wavelet power spectra were obtained and an original method was used to quantify statistically significant regions on the power spectra. The results both in the time and frequency domains indicate a higher TB and BR muscle activity for the strikes with impacts. No significant difference was found for the BB in the two different scenarios. In addition, the results show that the wavelet power spectra pattern for the three analysed muscles obtained from the strikes with and without impacts were similar

Development of EC technology in JAERI

International Nuclear Information System (INIS)

Sakamoto, Keishi; Takahashi, Koji; Kasugai, Atsushi; Hayashi, Kenichi; Ikeda, Yoshitaka; Kajiwara, Ken; Fujii, Tsuneyuki; Imai, Tsuyoshi; Kariya, Tsuyoshi; Mitsunaka, Yoshika

2003-01-01

Recent progress of electron cyclotron (EC) heating and current drive technologies in JAERI is reported. In 170 GHz gyrotron development, 0.9 MW/9.2 sec (efficiency: 43%), 0.5 MW/30 sec (46%), etc, have been demonstrated. As for 110 GHz gyrotron, 1 MW/5 sec and 1.2 MW/4.1 sec were obtained. Using four 110 GHz gyrotrons, a 3 MW power injection into JT- 60U plasma was carried out. In parallel, a launcher design and its development that includes neutron irradiation of the launcher components and a remote steering launcher are underway for ITER application. (authors)

Design of the ITER Electron Cyclotron Heating and Current Drive Waveguide Transmission Line

Science.gov (United States)

Bigelow, T. S.; Rasmussen, D. A.; Shapiro, M. A.; Sirigiri, J. R.; Temkin, R. J.; Grunloh, H.; Koliner, J.

2007-11-01

The ITER ECH transmission line system is designed to deliver the power, from twenty-four 1 MW 170 GHz gyrotrons and three 1 MW 127.5 GHz gyrotrons, to the equatorial and upper launchers. The performance requirements, initial design of components and layout between the gyrotrons and the launchers is underway. Similar 63.5 mm ID corrugated waveguide systems have been built and installed on several fusion experiments; however, none have operated at the high frequency and long-pulse required for ITER. Prototype components are being tested at low power to estimate ohmic and mode conversion losses. In order to develop and qualify the ITER components prior to procurement of the full set of 24 transmission lines, a 170 GHz high power test of a complete prototype transmission line is planned. Testing of the transmission line at 1-2 MW can be performed with a modest power (˜0.5 MW) tube with a low loss (10-20%) resonant ring configuration. A 140 GHz long pulse, 400 kW gyrotron will be used in the initial tests and a 170 GHz gyrotron will be used when it becomes available. Oak Ridge National Laboratory, managed by UT-Battelle, LLC, for the U.S. Dept. of Energy under contract DE-AC05-00OR22725.

Initial results of a high-power microwave sintering experiment at ORNL

International Nuclear Information System (INIS)

Kimrey, H.D.; White, T.L.; Bigelow, T.S.; Becher, P.F.

1986-01-01

Experiments have recently begun at Oak Ridge National Laboratory to develop microwave sintering techniques suitable for large ceramic parts. Microwave sintering offers the advantages of faster heating rates, more uniform heating, and greater energy efficiency than conventional sintering techniques. We are using 28-GHz, 200-kW cw gyrotrons as the heating source. An untuned cavity is used as the applicator to eliminate geometry sensitivity in coupling efficiency

A mode converter to generate a Gaussian-like mode for injection into the VENUS electron cyclotron resonance ion source

Energy Technology Data Exchange (ETDEWEB)

Lyneis, C., E-mail: CMLyneis@lbl.gov; Benitez, J.; Hodgkinson, A.; Strohmeier, M.; Todd, D. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Plaum, B. [Institut für Grenzflächenverfahrenstechnik und Plasmatechnologie (IGVP), Stuttgart (Germany); Thuillier, T. [Laboratoire de Physique Subatomique et de Cosmologie, Université Joseph Fourier Grenoble 1, CNRS/IN2P3, Institut Polytechnique de Grenoble, 53 rue des martyrs 38026 Grenoble cedex (France)

2014-02-15

A number of superconducting electron cyclotron resonance (ECR) ion sources use gyrotrons at either 24 or 28 GHz for ECR heating. In these systems, the microwave power is launched into the plasma using the TE{sub 01} circular waveguide mode. This is fundamentally different and may be less efficient than the typical rectangular, linearly polarized TE{sub 10} mode used for launching waves at lower frequencies. To improve the 28 GHz microwave coupling in VENUS, a TE{sub 01}-HE{sub 11} mode conversion system has been built to test launching HE{sub 11} microwave power into the plasma chamber. The HE{sub 11} mode is a quasi-Gaussian, linearly polarized mode, which should couple strongly to the plasma electrons. The mode conversion is done in two steps. First, a 0.66 m long “snake” converts the TE{sub 01} mode to the TE{sub 11} mode. Second, a corrugated circular waveguide excites the HE{sub 11} mode, which is launched directly into the plasma chamber. The design concept draws on the development of similar devices used in tokamaks and stellerators. The first tests of the new coupling system are described below.

Recent results of studies of plasma fluctuations in stellarators by microwave scattering technique

International Nuclear Information System (INIS)

Skvortsova, N.N.; Batanov, G.M.; Kolik, L.V.; Petrov, A.E.; Pshenichnikov, A.A.; Sarksyan, K.A.; Kharchev, N.K.; Khol'nov, Yu.V.; Kubo, S.; Sanchez, J.

2005-01-01

Microwave scattering diagnostics are described that allow direct measurements of the turbulent processes in a high-temperature plasma of magnetic confinement systems. Plasma density fluctuations in the heating region of the L-2M stellarator were measured from microwave scattering at the fundamental and the second harmonics of the heating gyrotron radiation. In the TJ-II stellarator, a separate 2-mm microwave source was used to produce a probing beam; the measurements were performed at the middle of the plasma radius. Plasma density fluctuations in the axial (heating) region of the LHD stellarator were measured from microwave scattering at the fundamental harmonic of the heating gyrotron radiation. Characteristic features of fluctuations, common for all three devices, are revealed with the methods of statistical and spectral analysis. These features are the wide frequency Fourier and wavelet spectra, autocorrelation functions with slowly decreasing tails, and non-Gaussian probability distributions of the magnitudes and the increments of the magnitude of fluctuations. The drift-dissipative instability and the instability driven by trapped electrons are examined as possible sources of turbulence in a high-temperature plasma. Observations showed the high level of coherence between turbulent fluctuations in the central region and at the edge of the plasma in L-2M. It is shown in L-2M that the relative intensity of the second harmonic of gyrotron radiation on the axis of a microwave beam after quasi-optical filtering in a four-mirror quasi-optical transmission line is about -50 dB of the total radiation intensity. Spatiotemporal structures in plasma density fluctuations were observed in the central region of the plasma column. The correlation time between the structures was found to be on the order of 1 ms. It is shown that, the spectrum of the signal from the second-harmonic scattering extends to higher frequencies in comparison with that from the fundamental

Status of the new multi-frequency ECRH system for ASDEX Upgrade

DEFF Research Database (Denmark)

Wagner, D.; Grünwald, G.; Leuterer, F.

2008-01-01

Currently, a new multi-frequency ECRH system is under construction at the ASDEX Upgrade tokamak experiment. This system employs, for the first time in a fusion device, multi-frequency gyrotrons, step-tunable in the range 105-140 GHz. The first two gyrotrons, working at 105 and 140 GHz, were...

Advancement of highly charged ion beam production by superconducting ECR ion source SECRAL (invited)

International Nuclear Information System (INIS)

Sun, L.; Lu, W.; Zhang, W. H.; Feng, Y. C.; Qian, C.; Ma, H. Y.; Zhang, X. Z.; Zhao, H. W.; Guo, J. W.; Yang, Y.; Fang, X.

2016-01-01

At Institute of Modern Physics (IMP), Chinese Academy of Sciences (CAS), the superconducting Electron Cyclotron Resonance (ECR) ion source SECRAL (Superconducting ECR ion source with Advanced design in Lanzhou) has been put into operation for about 10 years now. It has been the main working horse to deliver intense highly charged heavy ion beams for the accelerators. Since its first plasma at 18 GHz, R&D work towards more intense highly charged ion beam production as well as the beam quality investigation has never been stopped. When SECRAL was upgraded to its typical operation frequency 24 GHz, it had already showed its promising capacity of very intense highly charged ion beam production. And it has also provided the strong experimental support for the so called scaling laws of microwave frequency effect. However, compared to the microwave power heating efficiency at 18 GHz, 24 GHz microwave heating does not show the ω 2 scale at the same power level, which indicates that microwave power coupling at gyrotron frequency needs better understanding. In this paper, after a review of the operation status of SECRAL with regard to the beam availability and stability, the recent study of the extracted ion beam transverse coupling issues will be discussed, and the test results of the both TE 01 and HE 11 modes will be presented. A general comparison of the performance working with the two injection modes will be given, and a preliminary analysis will be introduced. The latest results of the production of very intense highly charged ion beams, such as 1.42 emA Ar 12+ , 0.92 emA Xe 27+ , and so on, will be presented

Research on nuclear fusion reactor - Development of mm-wve (Electron cyclotron) heating device

Energy Technology Data Exchange (ETDEWEB)

Ahn, Sae Young; Myung, Jung Su; Lee, Keun Ho; Lee, Myung Jae; Kim, Hyung Suk; Hur, Jin Woo; Song, Ho Young [Institute for Advanced Engineering, Seoul (Korea, Republic of)

1996-08-01

To establish cooperating system with foreign relevant research institutes, consultation has been given to IAE by Dr. T. V. George regarding ECRH and gyrotron development plan. Discussions with Prof. Temkin and Dr. Kreisher at MIT, who are working for ITER gyrotron development, were made and those helped IAE to collect necessary information for fundamental parameters of ECCD. Also, Prof. Vic Granatstein, U. of Maryland, and Dr. Baruch Levush, NRL, were consulted for computer codes of the gyrotron R and D. It will also be prepared for cooperation in ECCD and mm-wave heating with device research teams of General Atomics and Russia. By visiting various University labs and research institutes and investigating the up-to-date research results, the basic operating parameters of gyrotron for KSTAR project has been determined. By cooperation with MIT, a conceptual design has been made for the KSTAR gyrotron that should generate 1 MW and 110 GHz CW waves. The simulation result of EGUN using self-consistent theory shows that 1.2 MW power with the efficiency of 42.8% can be obtained for TE22,6,1 mode where the average ohmic loss is 0.54 kW/cm{sup 2} assuming 77 kV cathode voltage, 34 A beam current, velocity ratio of 1.62 and perpendicular velocity spread of 6.5%. 9 refs., 5 figs., 3 tabs. (author)

New development of advanced superconducting electron cyclotron resonance ion source SECRAL (invited)

International Nuclear Information System (INIS)

Zhao, H. W.; Sun, L. T.; Zhang, X. Z.; Guo, X. H.; Zhao, H. Y.; Feng, Y. C.; Li, J. Y.; Ma, H. Y.; Ma, B. H.; Wang, H.; Li, X. X.; Xie, D. Z.; Lu, W.; Cao, Y.; Shang, Y.

2010-01-01

Superconducting electron cyclotron resonance ion source with advance design in Lanzhou (SECRAL) is an 18-28 GHz fully superconducting electron cyclotron resonance (ECR) ion source dedicated for highly charged heavy ion beam production. SECRAL, with an innovative superconducting magnet structure of solenoid-inside-sextupole and at lower frequency and lower rf power operation, may open a new way for developing compact and reliable high performance superconducting ECR ion source. One of the recent highlights achieved at SECRAL is that some new record beam currents for very high charge states were produced by 18 GHz or 18+14.5 GHz double frequency heating, such as 1 e μA of 129 Xe 43+ , 22 e μA of 209 Bi 41+ , and 1.5 e μA of 209 Bi 50+ . To further enhance the performance of SECRAL, a 24 GHz/7 kW gyrotron microwave generator was installed and SECRAL was tested at 24 GHz. Some promising and exciting results at 24 GHz with new record highly charged ion beam intensities were produced, such as 455 e μA of 129 Xe 27+ and 152 e μA of 129 Xe 30+ , although the commissioning time was limited within 3-4 weeks and rf power only 3-4 kW. Bremsstrahlung measurements at 24 GHz show that x-ray is much stronger with higher rf frequency, higher rf power. and higher minimum mirror magnetic field (minimum B). Preliminary emittance measurements indicate that SECRAL emittance at 24 GHz is slightly higher that at 18 GHz. SECRAL has been put into routine operation at 18 GHz for heavy ion research facility in Lanzhou (HIRFL) accelerator complex since May 2007. The total operation beam time from SECRAL for HIRFL accelerator has been more than 2000 h, and 129 Xe 27+ , 78 Kr 19+ , 209 Bi 31+ , and 58 Ni 19+ beams were delivered. All of these new developments, the latest results, and long-term operation for the accelerator have again demonstrated that SECRAL is one of the best in the performance of ECR ion source for highly charged heavy ion beam production. Finally the future development

Electron cyclotron heating of plasmas

International Nuclear Information System (INIS)

Guest, Gareth

2009-01-01

As nuclear fusion becomes an increasingly important potential energy source in these times of global oil and energy crises, the development of technologies that can lead to the realization of this virtually inexhaustible source of energy takes on ever greater urgency. Over the past decade electron cyclotron heating has undergone a significant maturation and has emerged as an essential component of the major approaches to achieving controlled nuclear fusion. The gyrotron, first developed in the Soviet Union, has made it possible to employ ECH in large tokamak and stellarator fusion devices by providing megawatts of microwave power at frequencies above 100 GHz. A contemporary VGT-8110 gyrotron, for example, shown here with Kevin Felch and Pat Cahalan of Communications and Power Industries, is capable of delivering 10 second pulses of 1 MW of power at 110 GHz. The present monograph addresses the ECH physics critical to the international fusion reactor experiment, ITER, but also presents the fundamentals of ECH that are essential to its successful implementation in applications that range from active experiments in planetary magnetospheres to commercial plasma sources for the manufacture of computer chips. The book seeks to convey the physics of ECH in an orderly and coherent fashion to a professional audience by presenting the basic theoretical foundations and then using the theory to interpret a number of established experimental results. Exercises are included to aid the reader in making the theory more concrete. (orig.)

Power systems for the Doublet III 2-MW ECH system

International Nuclear Information System (INIS)

Remsen, D.B. Jr.

1981-10-01

A system providing 5 second pulses at 60 GHz from ten 200 kW gyrotrons is being prepared for electron cyclotron heating experiments on Doublet III. The power supply for the gyrotron system is a power supply currently under construction by Universal Voltronics Corporation for the Doublet III neutral beam power supply, and is to have the option of reverse polarity (negative) to fill the needs of the system of ten gyrotons operating in parallel. The output of this power supply is 80 kV at 100A for 5 second pulses with good regulation. The output pulse rise and fall times and fault protection response time are all compatible with the gyrotron requirements

The Compact Ignition Tokamak and electron cyclotron heating: Description of need; assessment of prospects

International Nuclear Information System (INIS)

Ignat, D.W.; Cohn, D.R.; Woskov, P.P.

1989-01-01

The CIT will benefit from auxiliary heating of 10 to 40 MW. The schedules of both the CIT construction project and the operating plan contain adequate time to develop and implement ECH systems based on the gyrotron and the induction free electron laser (IFEL). Each approach has advantages and is the object of R and D at the level of many millions of dollars per year. While the gyrotron is further advanced in terms of power and pulse length achieved, rapid progress is scheduled for the IFEL, including experiments on tokamaks. Plans of CIT, gyrotron, and IFEL make 1992 an appropriate time frame to commit to one or both systems. 12 refs., 8 figs., 2 tabs

EFECTO DEL GRITO COMO UN RECURSO ERGOGÉNICO PSICOLÓGICO EN PRACTICANTES DE KUNG FU

Directory of Open Access Journals (Sweden)

Juan Diego Zamora Salas

2002-12-01

Full Text Available El presente estudio analizó el efecto del grito como mecanismo inhibidor de sensaciones como el dolor y la fatiga enpracticantes de Kung Fu, utilizando una prueba de push ups. Se formaron tres grupos de forma aleatoria,cada uno conformado por n= 10, cuyas edades estaban comprendidas entre los 15 y 30 años. Los sujetos del Grupo Experimental sin grito y Grupo Experimental con grito, les correspondía realizar las prácticas depush ups aplicando los tratamientos correspondientes durante cinco semanas; mientras que los sujetos delgrupo control no realizaban éstas prácticas durante el período establecido, sólo les correspondía el pre-testy post-test. A los valores recolectados durante las pruebas se les aplicó una Anova 3 x 2 y un análisis posthocde la interacción mostrando la existencia de una diferencia significativa entre el pre-test y el post-testtanto en el grupo que aplicó el grito personal como en el grupo que no lo aplicó, lo cual no se manifestóentre el pre-test y post-test del grupo control. Al comparar los datos obtenidos del grupo que utilizó el gritopersonal con respecto al grupo que no utilizó el grito como tratamiento, se encontró una diferenciasignificativa entre ambos métodos. Con el estudio se concluyó que el grito en combinación con el ejerciciofísico permite observar incrementos significativos en la cantidad de repeticiones de un ejercicio de fuerzapara el tren superior como son las push ups, luego de cinco semanas de tratamiento.

A fast switch, combiner and narrow-band filter for high-power millimetre wave beams

Science.gov (United States)

Kasparek, W.; Petelin, M. I.; Shchegolkov, D. Yu; Erckmann, V.; Plaum, B.; Bruschi, A.; ECRH Groups at IPP Greifswald; Karlsruhe, FZK; Stuttgart, IPF

2008-05-01

A fast directional switch (FADIS) is described, which allows controlled switching of high-power microwaves between two outputs. A possible application could be synchronous stabilization of neoclassical tearing modes (NTMs). Generally, the device can be used to share the installed EC power between different types of launchers or different applications (e.g. in ITER, midplane/upper launcher). The switching is performed electronically without moving parts by a small frequency-shift keying of the gyrotron (some tens of megahertz), and a narrow-band diplexer. The device can be operated as a beam combiner also, which offers attractive transmission perspectives in multi-megawatt ECRH systems. In addition, these diplexers are useful for plasma diagnostic systems employing high-power sources due to their filter characteristics. The principle and the design of a four-port quasi-optical resonator diplexer is presented. Low-power measurements of switching contrast, mode purity and efficiency show good agreement with theory. Preliminary frequency modulation characteristics of gyrotrons are shown, and first results from high-power switching experiments using the ECRH system for W7-X are presented.

A fast switch, combiner and narrow-band filter for high-power millimetre wave beams

International Nuclear Information System (INIS)

Kasparek, W.; Plaum, B.; Petelin, M.I.; Shchegolkov, D.Yu; Erckmann, V.; Bruschi, A.

2008-01-01

A fast directional switch (FADIS) is described, which allows controlled switching of high-power microwaves between two outputs. A possible application could be synchronous stabilization of neoclassical tearing modes (NTMs). Generally, the device can be used to share the installed EC power between different types of launchers or different applications (e.g. in ITER, midplane/upper launcher). The switching is performed electronically without moving parts by a small frequency-shift keying of the gyrotron (some tens of megahertz), and a narrow-band diplexer. The device can be operated as a beam combiner also, which offers attractive transmission perspectives in multi-megawatt ECRH systems. In addition, these diplexers are useful for plasma diagnostic systems employing high-power sources due to their filter characteristics. The principle and the design of a four-port quasi-optical resonator diplexer is presented. Low-power measurements of switching contrast, mode purity and efficiency show good agreement with theory. Preliminary frequency modulation characteristics of gyrotrons are shown, and first results from high-power switching experiments using the ECRH system for W7-X are presented

The Herb Medicine Formula “Chong Lou Fu Fang” Increases the Cytotoxicity of Chemotherapeutic Agents and Down-Regulates the Expression of Chemotherapeutic Agent Resistance-Related Genes in Human Gastric Cancer Cells In Vitro

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Yongping Liu

2011-01-01

Full Text Available The herb medicine formula “Chong Lou Fu Fang” (CLFF has efficacy in inhibiting the proliferation of human gastric cancer in vitro and in vivo. To explore the potentially useful combination of CLFF with chemotherapeutic agents commonly used in gastric cancer therapy, we assess the interaction between CLFF and these chemotherapeutic agents in both SGC-7901 cell lines and BGC-823 cell lines using a median effect analysis and apoptosis analysis, and we also investigate the influence of CLFF on chemotherapeutic agent-associated gene expression. The synergistic analysis indicated that CLFF had a synergistic effect on the cytotoxicity of 5-fluorouracil (5-FU in a relative broad dose inhibition range (20–95% fraction affected in SGC-7901cell lines and 5–65% fraction affected in BGC-823 cell lines, while the synergistic interaction between CLFF and oxaliplatin or docetaxel only existed in a low dose inhibition range (≤50% fraction affected in both cell lines. Combination of CLFF and chemotherapeutic agents could also induce apoptosis in a synergistic manner. After 24 h, CLFF alone or CLFF combination with chemotherapeutic agents could significantly suppress the levels of expression of chemotherapeutic agent resistance related genes in gastric cancer cells. Our findings indicate that there are useful synergistic interactions between CLFF and chemotherapeutic agents in gastric cancer cells, and the possible mechanisms might be partially due to the down-regulation of chemotherapeutic agent resistance related genes and the synergistic apoptotic effect.

Development of two series ingnitron based crowbar protection system for 42 GHz and 82.6 GHz gyroton in SST-1

International Nuclear Information System (INIS)

Dhorajiya, Pragnesh; Dalakoti, Shefali; Patel, Harshida; Ingle, Krunal; Patel, Jatin; Sathyanarayana, K.; Rajanbabu; Shukla, B.K.

2013-01-01

Gyrotrons are used to generate the high power at microwave frequency that is used to heat the plasma inside a Tokamak. A conventional high voltage power supply is used for the testing of 82.6 GHz, 200 kW/CW and 42 GHz, 500 kW/500ms gyrotrons at our institute. Its maximum operating cathode parameters are -55 kV DC, 20 A. Like any other High RF power tubes gyrotrons need to be protected against arc faults within the tube. If the energy dumped in such arc fault is more than the critical crater energy of the tube, irreparable damage can occur inside the RF tube or microwave tube and rendering it useless. The specified maximum fault energy for the 42 GHz and 82.6 GHz gyrotrons is 10 joules. When conventional HVDC power supplies feed high power RF tubes or microwave tubes, a reliable crowbar protection is required which is tested separately to limit the energy to the tube in case of any type of fault to assure the tube safety. Two series ignitron (NL-37248) based crowbar system developed in-house is used to limit the arc fault energy under the acceptance level by diverting the fault current from the load or Gyrotron. Fault current diversion and interruption are initiated by the sensing element and protection system. The required protection cards are designed and developed in-house and required performance is achieved. With this crowbar system the high voltage switch-off to the gyrotron is achieved within 5 μsec after occurrence of critical faults. The crowbar is tested for voltage hold-off up to 80 kV DC. This paper presents the critical requirement of the time delay for the fault sensing and crowbar trigger generation and necessary protections that are incorporated with the ignitron switch crowbar like over voltage, pulsed over current and continuous over current. The crowbar system developed in-house, tested at rated value. The results obtained during the stand-alone tests and commissioning tests are also mentioned. Using this crowbar system the high voltage power

Initial results for a 170 GHz high power ITER waveguide component test stand

Science.gov (United States)

Bigelow, Timothy; Barker, Alan; Dukes, Carl; Killough, Stephen; Kaufman, Michael; White, John; Bell, Gary; Hanson, Greg; Rasmussen, Dave

2014-10-01

A high power microwave test stand is being setup at ORNL to enable prototype testing of 170 GHz cw waveguide components being developed for the ITER ECH system. The ITER ECH system will utilize 63.5 mm diameter evacuated corrugated waveguide and will have 24 >150 m long runs. A 170 GHz 1 MW class gyrotron is being developed by Communications and Power Industries and is nearing completion. A HVDC power supply, water-cooling and control system has been partially tested in preparation for arrival of the gyrotron. The power supply and water-cooling system are being designed to operate for >3600 second pulses to simulate the operating conditions planned for the ITER ECH system. The gyrotron Gaussian beam output has a single mirror for focusing into a 63.5 mm corrugated waveguide in the vertical plane. The output beam and mirror are enclosed in an evacuated duct with absorber for stray radiation. Beam alignment with the waveguide is a critical task so a combination of mirror tilt adjustments and a bellows for offsets will be provided. Analysis of thermal patterns on thin witness plates will provide gyrotron mode purity and waveguide coupling efficiency data. Pre-prototype waveguide components and two dummy loads are available for initial operational testing of the gyrotron. ORNL is managed by UT-Battelle, LLC, for the U.S. Dept. of Energy under Contract DE-AC-05-00OR22725.

Characterization of high-power RF structures using time-domain field codes

International Nuclear Information System (INIS)

Shang, C.C.; DeFord, J.F.; Swatloski, T.L.

1992-01-01

We have modeled gyrotron windows and gyrotron amplifier sever structures for TE modes in the 100--150 GHz range and have computed the reflection and transmission characteristics from the field data. Good agreement with frequency domain codes and analytic analysis have been obtained for some simple geometries. We present results for realistic structures with lousy coatings and describe implementation of microwave diagnostics

Three-wave interaction during electron cyclotron resonance heating and current drive

DEFF Research Database (Denmark)

Nielsen, Stefan Kragh; Jacobsen, Asger Schou; Hansen, Søren Kjer

2016-01-01

Non-linear wave-wave interactions in fusion plasmas, such as the parametric decay instability (PDI) of gyrotron radiation, can potentially hamper the use of microwave diagnostics. Here we report on anomalous scattering in the ASDEX Upgrade tokamak during electron cyclotron resonance heating...... experiments. The observations can be linked to parametric decay of the gyrotron radiation at the second harmonic upper hybrid resonance layer....

Electron energy recuperation in gyrodevices

International Nuclear Information System (INIS)

Savilov, A. V.; Nusinovich, G. S.; Sinitsyn, O. V.

2008-01-01

For many applications of gyrodevices, it is extremely important to increase their overall efficiency and reduce the power consumption. Therefore, at present, there are many gyrotrons operating with depressed collectors. These gyrotrons and their depressed collectors are typically designed with the use of available numerical codes. This paper is devoted to the analysis of the energy recuperation in gyrotrons, which is performed with the use of the Hamiltonian formalism. Such consideration gives some insight into the physics of gyrodevices and can be useful for estimating the benefits from utilizing depressed collectors. Both single-cavity gyromonotrons and multicavity gyrodevices in which the last cavity is excited by a prebunched beam are analyzed. Special attention is paid to a three-cavity, frequency-quadrupling gyrodevice.

High-power microwave transmission and mode conversion program. Progress report, June 15, 1993--June 15, 1994

International Nuclear Information System (INIS)

Vernon, R.J.; Lorbeck, J.A.

1994-06-01

This report briefly discusses the following topics: (1) Quasi-optical converter design for Varian gyrotron SN 4.1; (2) Quasi-optical converter cold-test measurement; (3) Modification of geometrical-optics synthesized surfaces; (4)Diffraction synthesis; (5) Tapered dimpled launcher; (6) Work on Vlasov converter system for Varian gyrotron SN 4.1R; (7) Analysis of gyrotron spurious modes; (8) MIT code benchmarking; (9) Development of low-power efficiency test for Vlasov converters; (10) Investigation of optimal beam waist size and mode content for injection into a circular and rectangular corrugated waveguides; (11) The effect of corrugations on reduction of the fields at the wall of waveguides; (12) Shipping of a microwave scanner to Varian and further microwave scanner development; and (13) Code transferred to Varian

Annual review of Plasma Physics Laboratory, Kyoto University, April, 1983

International Nuclear Information System (INIS)

1983-04-01

The devices for additionally heating joul-heated plasma in the Heliotron E, such as electron cyclotron resonance heating and neutral beam injection, were in operation in 1982. In the ECRH experiment, the microwaves of 200 kW at 28 GHz were generated by a gyrotron, but the pulse width was extended from 10 ms to 40 ms this year. By this, a currentless plasma of Te-1 keV was achieved. In the NB1 experiment, the neutral beam of about 1.5 MW was injected into joule-heated plasma, and the plasma of Ti(O)-950 eV, Te(O)-800 eV and Ne = 3 x 10 19 /m 3 was attained. The first experiment to inject neutral beam into ECRH currentless plasma was carried out. By this method, the density of the plasma increased as well as the ion temperature and electron temperature. As to the theory, a critical beta was calculated by using stellarator expansion, which should be 3 to 7 % in the Heliotron E. Two gyrotrons of 200 kW at 53 GHz each and an ion cyclotron resonance heating equipment of 1.5 MW at 26.7 MHz are prepared. As to the reactor study, the design of Heliotron H in the first phase was completed. The location of impurity sources in NB1 ion sources and beam lines was found. (Kako, I.)

Therapeutic effects of FuZhiSan on Alzheimer's disease rat model:evaluation with PET imaging

International Nuclear Information System (INIS)

Guo Zhe; Zhang Jinming; Yao Shulin; Feng Huiru; Li Xuling; Yin Dayi; Tian Jiahe

2010-01-01

Objective: To assess the feasibility of using PET molecular imaging to evaluate the therapeutic effects of traditional Chinese medicine FuZhiSan (FZS) on the model of aging Alzheimer's disease (AD) rats. Methods: Twenty aged AD rats (Sparague-Dawley rats,male) were randomly divided into FZS treated group (n = 10) and control group (n = 10). Another 10 healthy adult rats were as blank controls. Morris water maze record system was used for cognitive function assessment. Before and after FZS treatment 18 F-fluorodeoxyglucose (FDG) and 11 C-2- [4'-(methylamino) phenyl] benzothiazol-6-ol (PIB) PET imaging was undertaken. After post-treatment imaging procedures the brain tissues of all animals were taken for histochemical study, such as staining with HE, congo red, amyloid β (Aβ) immunofluorescence, 5-bromo-2-deoxyuridine (BrdU) immunofluorescence and NeuN immunofluorescence. Paired t-test was performed with SPSS 13.0 software for the data analysis. Results: The cognitive dysfunction of aging AD rats was improved after FZS treatment. The escape latency in FZS treated group was significantly shorter than that of control group ((32.5 ±10.8) s vs (102.6±8.8) s, t =15.7987, P=0. 0001). Diffuse neuronal loss and Aβ deposition were detected in the hippocampus and cortex in the aged AD rats. The imaging data showed that brain glucose metabolism was amended in FZS treated group while the abatement of amyloid deposition was not significant. Immunofluorescence results indicated that the neuronal proliferation was more remarkable in FZS treated group. Conclusions: It may be feasible to use PET imaging as a method to evaluate the therapeutic effect in AD rats. FZS may ameliorate memory dysfunction of aged AD rats. Its mechanism may be partly contributed to the enhancement of the neuronal proliferation and survival. (authors)

Decreased Oxygen Transfer Capacity of Erythrocytes as a Cause of 5-Fluorouracil Related Ischemia

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Ivan Spasojević

2008-12-01

Full Text Available cisplatin have similar effects on the erythrocyte membrane, thus eliminating those changes as a potential source of cardiotoxicity. On the contrary, 31P-NMR and polarography showed that the effects of these cytostatics on the intracellular milieu differ significantly. 5-FU provoked a pronounced decrease of the O2 level in blood and affected the metabolism of phosphate compounds, while cisplatin had no such effects. When combined these two drugs showed synergistic effects, which matches the higher frequency of cardiotoxicity of the combination relative to the sole application of 5-FU. Preliminary results acquired on blood of patients receiving cisplatin/5-FU therapy verified observations obtained ex vivo. These results open a possibility of applying NMR in preclinical trials of new drugs in order to predict their ischemic potential.

Determination of electromagnetic modes in oversized corrugated waveguides on the electron cyclotron resonance heating installation at the tokamak Tore Supra; Determination de modes electromagnetiques de guides d'ondes corrugues surdimensionnes sur l'installation de chauffage des electrons de tokamak Tore Supra

Energy Technology Data Exchange (ETDEWEB)

Courtois, L

2001-03-09

Electron cyclotron resonance heating (ECRH) in the Tore Supra tokamak constitutes an important step in the research aimed at obtaining thermonuclear fusion reactions. Electron heating is achieved by transmitting an electromagnetic wave from the oscillators (gyrotrons) to the plasma via the fundamental mode, propagating in oversized corrugated waveguides. Maximizing the proportion of the gyrotron power coupled to the fundamental waveguide mode is essential for the good functioning of the transmission line and for maximizing the effect on the plasma. This thesis gives all necessary tools for finding the proportion of the fundamental mode and all other modes present in passive components and at the output of the gyrotron as installed in the Tore Supra ECRH plant. This characterisation is based on obtaining amplitude and phase diagrams of the electric field on a plane transverse to the propagation axis. The most difficult part of obtaining these diagrams is measuring the phase which, despite the very short wavelength, is measured directly at low power levels. At high power levels the phase is numerically reconstructed from amplitude measurements for gyrotron characterisation. A complete theoretical study of the phase reconstruction code is given including its validation with theoretical diagrams. This study allows the realisation of a modal characterisation unit electromagnetic for measurement of radiated beams and usable in each part of the ECRH installation. At the end, the complete modal characterisation is given at low level for a mode converter and also at high level for the first series gyrotron installed at TORE SUPRA. (author)

Recent results on electron cyclotron current drive and MHD activity in RTP

NARCIS (Netherlands)

Donne, A.J.H.; Schuller, F.C.; Oomens, A.A.M.; de Baar, M.R.; Barth, C.J.; Beurskens, M.N.A.; Box, F.M.A.; van Gelder, J.F.M.; Grobben, B.J.J.; Groot, de B.; Herranz, J.M.; Hogeweij, G.M.D.; Hokin, S.A.; Howard, J.; Hugenholtz, C.A.J.; Karelse, F.A.; de Kloe, J.; Kruijt, O.G.; Kuyvenhoven, S.; Lok, J.; Cardozo, N.J.L.; van der Meiden, H.J.; Meijer, F.G.; Montvai, A.; Oyevaar, T.; Pijper, F.J.; Polman, R.W.; Rommers, J.H.; Salzedas, F.; Schokker, B.C.; Smeets, P.H.M.; Tanzi, C.P.; Tito, C.J.; Verhaag, G.C.H.M.; Westerhof, E.

1997-01-01

The RTP tokamak (R = 0.72 m, a = 0.164 m, B-phi < 2 5.T, I-p = < 150 kA) is equipped with three gyrotrons (2 x 60 GHz, 180 kW, 100 ms each; 1 x 110 GHz, 500 kW, 200 ms) for electron cyclotron heating (ECH) and current drive (ECCD). The power from one of the 60 GHz gyrotrons is launched via an

Characterization of high-power RF structures using time-domain field codes

International Nuclear Information System (INIS)

Shang, C.C.; DeFord, J.F.; Swatloski, T.L.

1992-01-01

We have modeled gyrotron windows and gyrotron amplifier sever structures for TE modes in the 100-150 GHz range and have computed the reflection and transmission characteristics from the field data. Good agreement with frequency domain codes and analytic analysis have been obtained for some simple geometries. We present results for realistic structures with lossy coatings and describe implementation of microwave diagnostics. (Author) 5 figs., 7 refs

Trip electrical circuit of the gyrotion

International Nuclear Information System (INIS)

Rossi, J.O.

1987-09-01

The electron cyclotron resonance heating system of INPE/LAP is shown and the trip electrical circuit of the gyrotron is described, together with its fundamental aspects. The trip electrical circuit consists basically of a series regulator circuit which regulates the output voltage level and controls the pulse width time. Besides that, a protection circuit for both tubes, regulator and gyrotron, against faults in the system. (author) [pt

DISCOVERY OF A WIDE BINARY BROWN DWARF BORN IN ISOLATION

International Nuclear Information System (INIS)

Luhman, K. L.; Allen, P. R.; Mamajek, E. E.; Muench, A. A.; Finkbeiner, D. P.

2009-01-01

During a survey for stars with disks in the Taurus star-forming region using the Spitzer Space Telescope, we have discovered a pair of young brown dwarfs, FU Tau A and B, in the Barnard 215 dark cloud. They have a projected angular separation of 5.''7, corresponding to 800 AU at the distance of Taurus. To assess the nature of these two objects, we have obtained spectra of them and constructed spectral energy distributions. Both sources are young (∼1 Myr) according to their Hα emission, gravity-sensitive spectral features, and mid-infrared excess emission. The proper motion of FU Tau A provides additional evidence of its membership in Taurus. We measure spectral types of M7.25 and M9.25 for FU Tau A and B, respectively, which correspond to masses of ∼0.05 and ∼0.015 M sun according to the evolutionary models of Chabrier and Baraffe. FU Tau A is significantly overluminous relative to an isochrone passing through FU Tau B and relative to other members of Taurus near its spectral type, which may indicate that it is an unresolved binary. FU Tau A and B are likely to be components of a binary system based on the low probability (∼3 x 10 -4 ) that Taurus would produce two unrelated brown dwarfs with a projected separation of a ≤ 6''. Barnard 215 contains only one other young star and is in a remote area of Taurus, making FU Tau A and B the first spectroscopically confirmed brown dwarfs discovered forming in isolation rather than in a stellar cluster or aggregate. Because they were born in isolation and comprise a weakly bound binary, dynamical interactions with stars could not have played a role in their formation, and thus are not essential for the birth of brown dwarfs.

Elmo Bumpy Torus proof of principle, Phase II: Title 1 report. Volume IV. Microwave system. Preliminary design report

International Nuclear Information System (INIS)

Adams, R.N.

1982-01-01

The EBT-P Microwave System provides microwaves for electron cyclotron resonance heating (ECRH) to both stabilize and heat the EBT-P plasma. A 28 gigahertz (GHz) system is required to form the hot electron annulus plasma that provides MHD stabilization to the core plasma. A 60 GHz system is required to heat the core plasma and will provide some second harmonic heating of the hot electron annulus. The principal microwave system elements and their design characteristics are summarized. The microwave system includes 200 kilowatt (kW) gyrotrons at 60 GHz for core heating and 200 kW gyrotrons at 28 GHz for annulus heating. The basic operating complement will be six (6) 60 GHz tubes and two (2) 28 GHz tubes. PACE (Plant and Capital Equipment) procurement will include four (4) 60 GHz gyrotrons with two (2) GHz tubes procured under operations and the two (2) 28 GHz tubes will be provided, with mounts, from the EBT-S program. Each tube is rigidly mounted on an oil filled tank assembly which provides electrical isolation and cooling. All tubes and mounts will be located in the lower level of the torus enclosure. An extensive demineralized water flow system is required to provide gyrotron cooling

[Isolation and characterization of petroleum catabolic broad-host-range plasmids from Shen-Fu wastewater irrigation zone].

Science.gov (United States)

Wang, Ya-Fei; Wang, Ya-Fei; Li, Hui; Li, Xiao-Bin

2013-11-01

Based on triparental mating, we isolated a total of eight broad host range (BHR) petroleum hydrocarbon catabolic plasmids from the soils, sediments, and wastewater samples in the Shen-Fu irrigation zone. The antibiotic resistance of the plasmids was tested, and then, the plasmids were transferred to Escherichia coli EC100. The plasmids carrying no antibiotic resistance were tagged by miniTn5 transposon consisting of antibiotic resistant genes. The PCR-based incompatibility test revealed that the pS3-2C and pS4-6G belonged to Inc P group, the pS3-2G, pW22-3G, and pA15-7G belonged to Inc N group, the pS7-2G was identified as Inc W plasmid, and the pA23-1G and pA10-1C were placed into Inc Q group. By adopting the reported PCR amplification methods of petroleum hydrocarbon-degrading catabolic genes, the petroleum-degrading capability of these BHR plasmids were preliminarily analyzed. The plasmids pS3-2G, pS7-2G, pA23-1G, pW22-3G, and pA10-1C carried aromatic ring- hydroxylating dioxygenase gene phdA and toluene monooxygenase gene touA; the plasmid pA15-7G carried touA and toluene dioxygenase gene tod; the plasmid pS3-2C carried ben, phdA, and tod; whereas the pS4-6G only carried ben. The host range test showed that all the isolated plasmids except pS3-2C could be transferred and maintained stably in the representative strains Agrobacterium tumefaciens C58, Cupriavidus necator JMP228, and E. coli EC100 of the alpha-, beta-, and gamma-Proteobacteria, respectively.

The ReFuGe 2020 consortium - Using ‘omics’ approaches to explore the adaptability and resilience of coral holobionts to environmental change

Directory of Open Access Journals (Sweden)

Christian Robert Voolstra

2015-09-01

Full Text Available Human-induced environmental changes have been linked directly with loss of biodiversity. Coral reefs, which have been severely impacted by anthropogenic activities over the last few decades, exemplify this global problem and provide an opportunity to develop research addressing key knowledge gaps through ‘omics’-based approaches. While many stressors, e.g. global warming, ocean acidification, overfishing and coastal development have been identified, there is an urgent need to understand how corals function at a basic level in order to conceive strategies for mitigating future reef loss. In this regard, availability of fully sequenced genomes has been immensely valuable in providing answers to questions of organismal biology. Given that corals are metaorganisms comprised of the coral animal host, its intracellular photosynthetic algae, and associated microbiota (i.e. bacteria, archaea, fungi, viruses, these efforts must focus on entire coral holobionts. The Reef Future Genomics 2020 (ReFuGe 2020 consortium has formed to sequence hologenomes of ten coral species representing different physiological or functional groups to provide foundation data for coral reef adaptation research that is freely available to the research community.

Remote Control System of the TJ-II Microwave Transmission Lines Mirrors

International Nuclear Information System (INIS)

Lopez Sanchez, A.; Fernandez, A.; Cappa, A.; Gama, J. de la; Olivares, J.; Garcia, R.; Chamorro, M.

2007-01-01

The ECRH system of the TJ-II stellarator has two gyrotrons, which deliver a maximum power of 300 kW each at a frequency of 53.2 GHz. Another 28 GHz gyrotron will be used to heat the plasma by electron Bernstein waves (EBWH). The microwave power is transmitted from the gyrotrons to the vacuum chamber by two quasi-optical transmission lines for ECRH and a corrugated waveguide for EBWH. All transmission lines have an internal movable mirror inside the vacuum chamber to focus the beam and to be able to change the launching angle. The control of the beam polarization is very important and the lines have two corrugated mirrors, which actuate as polarizers. In this report the control system of the position of these three internal mirrors and the polarizers of the EBWH transmission line is described. (Author) 20 refs