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Sample records for sorin co-i sule

  1. Swift Ultra Long Endurance (SULE) Unmanned Air Vehicle (UAV), Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Swift proposes to design, fabricate, and fly a Swift Ultra Long Endurance (SULE) 30-day mission HALE UAS with flight tests including: 24-hrs, 48-hrs, and 7-days...

  2. FERNANDO SORIN (1778–1839) KITARAFANTASIAT YHDELLE SOITTAJALLE – semioottisia analyysejä

    OpenAIRE

    Haukka, Aleksi

    2016-01-01

    Tässä pro gradu -työssä käsitellään espanjalaisen Fernando Sorin (1778–1839) kitarafantasioita yhdelle soittajalle. Näkökulma sävellysten analyysiin on semioottinen ja erityisesti eksistentiaalisemioottinen. Tutkimus pitää sisällään myös laajan Fernando Sorin elämäkerran, jonka lopuksi Sorin elämänvaiheita analysoidaan eksistentiaalisemioottisesta näkökulmasta. Metodologisina lähtökohtina ovat Eero Tarastin eksistentiaalisemiotiikka ja etenkin niin sanottu z-malli tai zemic-malli. Olennai...

  3. Short-term and mid-term results with the Sorin Freedom Solo aortic valve.

    Science.gov (United States)

    Ustunsoy, Hasim; Yasim, Alptekin; Deniz, Hayati; Gokaslan, Gokhan; Ozcaliskan, Ozerdem

    2013-03-01

    The study aim was to present the short- and mid-term results for patients who underwent aortic valve replacement (AVR) with the Sorin Freedom Solo third-generation stentless prosthetic valve. AVR with a Sorin Freedom Solo valve was performed in 14 patients between March 2006 and March 2011. Patients aged > or = 60 years (male:female ratio 6:8; mean age 73.28 +/- 5.42 years) who required AVR with the Sorin Freedom Solo valve according to the surgeon's choice were included in the study. The valvular prosthesis was implanted in the supra-annular position, using a single suture line. Eight patients underwent an isolated AVR; combined interventions were carried out in the other patients due to concomitant cardiac disease. One patient died during the immediate perioperative period, and two more during the follow up, from non-cardiac causes. The mean maximum transvalvular gradient of patients with aortic stenosis was 88.1 +/- 20.2 mmHg, and this fell to 26.4 +/- 7.6 mmHg during the early postoperative period. The mean gradient at one year of follow up was further decreased to 19.4 +/- 5.3 mmHg. The left ventricular end-diastolic and end-systolic diameters were also significantly reduced, from 4.8 +/- 0.9 to 4.3 +/- 0.6 cm and from 3.2 +/- 0.6 to 2.8 +/- 5.3 cm, respectively. The average left ventricular ejection fraction was 60.2 +/- 4.9% preoperatively, and 63.2 +/- 2.1% at one year after surgery (p = NS). No paravalvular leakage, endocarditis, prosthesis failure or neurologic events were reported among patients. The Sorin Freedom Solo stentless valve has provided good early and intermediate-term results. Implantation of the prosthesis is straightforward, with low rates of morbidity and mortality. However, these data require further support from larger patient series and long-term follow up.

  4. Long-Term Outcome of the Sorin Freedom SOLO Stentless Aortic Valve.

    Science.gov (United States)

    Christ, Torsten; Claus, Benjamin; Zielinski, Christina; Falk, Volkmar; Grubitzsch, Herko

    2016-11-01

    The Sorin Freedom SOLO valve is a third-generation stentless aortic valve which shows beneficial hemodynamic performance compared to stented bioprostheses. Long-term results regarding hemodynamics, the durability of the valve, and patient outcome are scarce, and their acquisition was the aim of this single-center study. Between 2005 and 2006, a total of 68 consecutive patients (30 males, 38 females; mean age at surgery 76.1 ± 6.3 years) underwent aortic valve replacement with a Sorin Freedom SOLO prosthesis. Indications were aortic stenosis (n = 50), aortic regurgitation (n = 1) and mixed lesions (n = 17). Associated procedures were performed in 31 patients (45.6%), most of which were coronary artery bypass grafting (68.8 %). The follow up was performed by telephone interviews, and clinical and echocardiographic examinations. Morbidity, mortality and echocardiographic data were analyzed. The total follow up was 501.1 patient-years, with a mean follow up of 7.4 ± 3.4 years (maximum 11.2 years). The follow up was 100% complete. Hospital mortality was 4.4% (n = 3). Actuarial survival at five and 10 years was 76.5 ± 5.1% and 41.5 ± 6.5%, respectively. Reinterventions were performed in eight patients; these included three reoperations due to endocarditis, four transcatheter aortic valve implantations, and one reoperation due to structural valve deterioration (SVD). The overall freedom from valve reintervention due to SVD at five and 10 years was 97.8 ± 2.2% and 82.9 ± 7.5%, respectively. After eight years, echocardiography demonstrated peak and mean transvalvular gradients of 18 ± 11 and 10 ± 7 mmHg, respectively. The overall effective and indexed aortic valve orifice areas were 1.73 ± 0.58 cm2 and 0.92 ± 0.33 cm2/m2, respectively. At long-term follow up the Sorin Freedom SOLO bioprosthesis was associated with favourable hemodynamic results and survival. Freedom from SVD was not superior to that occurring with stented bioprostheses.

  5. Heart valve replacement with the Sorin tilting-disc prosthesis. A 10-year experience.

    Science.gov (United States)

    Milano, A; Bortolotti, U; Mazzucco, A; Mossuto, E; Testolin, L; Thiene, G; Gallucci, V

    1992-02-01

    From 1978 to 1988, 697 patients with a mean age of 48 +/- 11 years (range 5 to 75 years) received a Sorin tilting-disc prosthesis; 358 had had aortic valve replacement, 247 mitral valve replacement, and 92 mitral and aortic valve replacement. Operative mortality rates were 7.8%, 11.3%, and 10.8%, respectively, in the three groups. Cumulative duration of follow-up is 1650 patient-years for aortic valve replacement (maximum follow-up 11.4 years), 963 patient-years for mitral valve replacement (maximum follow-up 9.9 years) and 328 patient-years for mitral and aortic valve replacement (maximum follow-up 9.4 years). Actuarial survival at 9 years is 72% +/- 4% after mitral valve replacement, 70% +/- 3% after aortic valve replacement, and 50% +/- 12% after mitral and aortic valve replacement, and actuarial freedom from valve-related deaths is 97% +/- 2% after mitral valve replacement, 92% +/- 2% after aortic valve replacement, and 62% +/- 15% after mitral and aortic valve replacement. Thromboembolic events occurred in 21 patients with aortic valve replacement (1.3% +/- 0.2%/pt-yr), in 12 with mitral valve replacement (1.2% +/- 0.3% pt-yr), and in seven with mitral and aortic valve replacement (2.1% +/- 0.8%), with one case of prosthetic thrombosis in each group; actuarial freedom from thromboembolism at 9 years is 92% +/- 3% after mitral valve replacement, 91% +/- 3% after aortic valve replacement, and 74% +/- 16% after mitral and aortic valve replacement. Anticoagulant-related hemorrhage was observed in 15 patients after aortic valve replacement (0.9% +/- 0.2%/pt-yr), in 9 after mitral valve replacement (0.9% +/- 0.3%/pt-yr), and in 6 with mitral and aortic valve replacement (0.9% +/- 0.5%/pt-yr); actuarial freedom from this complication at 9 years is 94% +/- 2% after aortic valve replacement, 91% +/- 4% after mitral valve replacement, and 68% +/- 16% after mitral and aortic valve replacement. Actuarial freedom from reoperation at 9 years is 97% +/- 2% after mitral and

  6. Improved stability and enhanced efficiency to degrade chlorimuron-ethyl by the entrapment of esterase SulE in cross-linked poly (γ-glutamic acid)/gelatin hydrogel

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Liqiang [State Key Laboratory of Forest and Soil Ecology, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang (China); University of Chinese Academy of Sciences, Beijing (China); Li, Xinyu; Li, Xu; Su, Zhencheng; Zhang, Chenggang; Xu, MingKai [State Key Laboratory of Forest and Soil Ecology, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang (China); Zhang, Huiwen, E-mail: hwzhang@iae.ac.cn [State Key Laboratory of Forest and Soil Ecology, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang (China)

    2015-04-28

    Highlights: • Esterase SulE was entrapped in a three-dimensional network of CPE. • CPE-SulE obviously improved thermostability, pH stability and reusability. • CPE-SulE displayed obviously enhanced efficiency in degrading chlorimuron-ethyl. • The three-dimensional network and kinetic parameters of CPE-SulE were analysed. • CPE-SulE possesses the great potential to remediate chlorimuron-ethyl contaminated in situ. - Abstract: Free enzymes often undergo some problems such as easy deactivation, low stability, and less recycling in biodegradation processes, especially in soil condition. A novel esterase SulE, which is responsible for primary degradation of a wide range of sulfonylurea herbicides by methyl or ethyl ester de-esterification, was expressed by strain Hansschlegelia sp. CHL1 and entrapped for the first time in an environment-friendly, biocompatible and biodegradable cross-linked poly (γ-glutamic acid)/gelatin hydrogel (CPE). The activity and stability of CPE-SulE were compared with free SulE under varying pH and temperature condition by measuring chlorimuron-ethyl residue. Meanwhile, the three-dimensional network of CPE-SulE was verified by scanning electron microscopy (SEM). The results showed that CPE-SulE obviously improved thermostability, pH stability and reusability compared with free SulE. Furthermore, CPE-SulE enhanced degrading efficiency of chlorimuron-ethyl in both soil and water system, especially in acid environment. The characteristics of CPE-SulE suggested the great potential to remediate chlorimuron-ethyl contaminated soils in situ.

  7. Improved stability and enhanced efficiency to degrade chlorimuron-ethyl by the entrapment of esterase SulE in cross-linked poly (γ-glutamic acid)/gelatin hydrogel

    International Nuclear Information System (INIS)

    Yang, Liqiang; Li, Xinyu; Li, Xu; Su, Zhencheng; Zhang, Chenggang; Xu, MingKai; Zhang, Huiwen

    2015-01-01

    Highlights: • Esterase SulE was entrapped in a three-dimensional network of CPE. • CPE-SulE obviously improved thermostability, pH stability and reusability. • CPE-SulE displayed obviously enhanced efficiency in degrading chlorimuron-ethyl. • The three-dimensional network and kinetic parameters of CPE-SulE were analysed. • CPE-SulE possesses the great potential to remediate chlorimuron-ethyl contaminated in situ. - Abstract: Free enzymes often undergo some problems such as easy deactivation, low stability, and less recycling in biodegradation processes, especially in soil condition. A novel esterase SulE, which is responsible for primary degradation of a wide range of sulfonylurea herbicides by methyl or ethyl ester de-esterification, was expressed by strain Hansschlegelia sp. CHL1 and entrapped for the first time in an environment-friendly, biocompatible and biodegradable cross-linked poly (γ-glutamic acid)/gelatin hydrogel (CPE). The activity and stability of CPE-SulE were compared with free SulE under varying pH and temperature condition by measuring chlorimuron-ethyl residue. Meanwhile, the three-dimensional network of CPE-SulE was verified by scanning electron microscopy (SEM). The results showed that CPE-SulE obviously improved thermostability, pH stability and reusability compared with free SulE. Furthermore, CPE-SulE enhanced degrading efficiency of chlorimuron-ethyl in both soil and water system, especially in acid environment. The characteristics of CPE-SulE suggested the great potential to remediate chlorimuron-ethyl contaminated soils in situ

  8. Benefits and medium-term outcome of the Sorin Pericarbon Freedom stentless aortic prosthesis in cases of acute bacterial endocarditis.

    Science.gov (United States)

    Stefanelli, Guglielmo; Pirro, Fabrizio; Meli, Marco; Trevisan, Davide; Telesca, Mariassunta; Campisano, Barbara; Mussini, Cristina; Barbieri, Andrea

    2016-10-01

    The aim of this study is to evaluate the ease of use and the advantages of Sorin Pericarbon Freedom (SPF) stentless valve in cases of acute bacterial endocarditis and to check the intermediate-term results after the implant of SPF with respect to resistance to infection, valve deterioration and durability. Between June 2003 and February 2015, 26 patients with active aortic valve bacterial endocarditis underwent aortic valve replacement with SPF pericardial stentless aortic prosthesis. The mean age was 57 ± 18 years; 73% of the patients were in preoperative NYHA class III and VI. Mean Logistic EuroSCORE was 14.2 ± 12.7. Endocarditis occurred in 18 patients with native valves, and in 9 patients with prosthetic valves (4 mechanical aortic valve prostheses; 5 aortic bioprostheses). Aortic root abscesses were observed in 16 cases (61.5%). Surgery was emergent in 3 cases (11.5%). Redo surgery was performed in 9 cases (35%). Cumulative follow-up was 126.8 patient-years (mean 4.9 ± 3.3 years). Operative hospital mortality was 0% for all patients. Residual mean prosthetic gradient at discharge was 9.4 ± 3.6 mmHg. Neither residual aortic incompetence nor residual abscess cavity was observed at discharge. Mean ejection fraction at discharge was 54 ± 8% (Min; Max: 35%; 65%). A total of 4 patients died at follow-up, all for non-cardiac causes. One patient was lost to follow-up. Two patients (8%) underwent non-valve-related reoperation with 0% mortality. Residual mean gradient at follow-up was 7.2 ± 2.1 mmHg. Three patients (17%) presented with mild/moderate aortic incompetence and 89% of patients were in NYHA Class I-II at follow-up. At 9 years, actuarial freedom from valve-related reoperation and from structural valve deterioration was 100%. The SPF aortic prosthesis is a true pericardial stentless prosthesis suitable for the treatment of acute bacterial endocarditis. Intermediate-time results in terms of freedom from reoperation, structural valve deterioration and

  9. Cholecystectomy without Operative Cholangiography. | Sule | East ...

    African Journals Online (AJOL)

    Serum bilirubin, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were increased 7.8, 1.6, 2.95 and 3.85 times beyond their average normal reference values. The mean CBD diametter was 1.74cm. All CBDS were palpated at operation. Serum amylase was normal in all our patients including ...

  10. FIREBall-2: Trailblazing observations of the space UV circumgalactic medium (Columbia University, Co-I Proposal)

    Science.gov (United States)

    Schiminovich, David

    Columbia University is a Co-I institution in a collaborative research program with Caltech, the Lead Institution (PI: Christopher Martin). The Faint Intergalactic-medium Redshifted Emission Balloon (FIREBall-2) is designed to discover and map faint emission from the circumgalactic medium of low redshift galaxies (0.3zz 0.7, conduct a targeted search of circumquasar (CQM) media for selected targets, and conduct follow up on likely tar-gets selected via GALEX and a pilot survey conducted by our group. We will also conduct a statistical search for the faint IGM via statistical stacking of our data. The FIREBall-2 team includes two female graduate students in key roles (both of whom are finishing their PhDs in 2016) and is overseen by a female Postdoctoral scholar (supported by NSF AAPF and Caltech Millikan Fellowships, in addition to a recent Roman Technology Fellowship award). Additional funding is necessary to keep this highly qualified balloon team together for a second flight. FIREBall-2 will test key technologies and science strategies for a future space mission to map emission from CGM and IGM baryons. Its flights will continue to provide important training for the next generation of space astrophysicists working in UV and other wavelength instrumentation. Most importantly, FIREBall-2 will detect emission from the CGM of nearby galaxies, providing the first census of the density and kinematics of this material for low z galaxies and open-ing a new field of CGM science.

  11. [Phylogenetic analysis of CO I gene of Oncomelania snails from project of afforestation for schistosomiasis control in marshland endemic regions].

    Science.gov (United States)

    Xu, Yu-Mei; Zhang, Shi-Qing; Zhu, Chuan-Gang

    2012-04-01

    To investigate the genetic difference of cytochrome oxidase I (CO I ) of Oncomelania snails from the project of afforestation for schistosomiasis control in marshland regions, so as to explore the effects of different ecological environments. The snails were collected from 3 different areas, Anqing, Tongling, Wuwei, i.e. the upstream, midstream and downstream regions along the Yangtz River in Anhui Province. Genomic DNA was extracted from the snails, and CO I gene fragments were amplified by PCR, then purified and sequenced. The sequences were edited by using Blast. The CO I genes of O. h. minima and Biomphalaria glabrata were used as the reference of exogenous gene. The genetic distances of the various regions were calculated by the Kimura method and phylogenetic trees were constructed with UPGMA and the NJ method of MEGA (3.1) software. The amplified CO I gene of the snail was a fragment about 700 bp including 2 primers in length. There were little genetic diversity among the different areas, the identities were higher than or equal to 98%. The genetic distances indicated that the distance between the projects of afforestation and woodland in Anqing was 0.003, while Tongling was 0.019, Wuwei was 0.007. The distances among the three projects of afforestation were 0.003-0.012. The two phylogenetic trees were constructed by the methods of UPGMA and NJ respectively, which took on very similar topo-structure in which isolates of Biomphalaria glabrata located in one clade and all the others in the other one. In the other one clade, O. H. minima located in one clade. There was little genetic diversity among Anqing, Tongling, Wuwei clusters. The afforestations of Anqing and Wuwei clustered into one group, while the woodlands of Anqing and Wuwei appeared as another group. There is a little genetic diversity of the snail cytochrome oxidase I (CO I ) in different ecological environments among the upstream, midstream and downstream regions along the Yangtz River in Anhui

  12. Dynamics of the Community of Inquiry (CoI within a Massive Open Online Course (MOOC for In-Service Teachers in Environmental Education

    Directory of Open Access Journals (Sweden)

    Maya Kaul

    2018-03-01

    Full Text Available One of the greatest ways to transform education systems is to develop community-centered professional supports for in-service teachers. Given the rise of distance learning platforms such as massive open online courses (MOOCs, there is a growing potential to deliver such supports at scale. The community of inquiry (CoI framework models the asynchronous, text-based communication that defines educational experiences within such collaborative learning environments; however, methods of CoI transcript analysis must be improved. This paper uses the University of Helsinki’s 2016 MOOC, Sustainable Energy in Education, as a case study on how the CoI framework can be used to characterize the educational experience of in-service teachers in distance learning environments. Using the CoI coding protocol, this paper employs a transcript analysis of the discussion forum posts on the MOOC (n = 78, and applies improved measures of reliability in order to understand the capacity of CoI transcript analysis to reliably define online learning experiences. The findings suggest that, while the CoI framework is able to characterize some elements of online learning communities, more work needs to be done to ensure the framework captures the more nuanced elements of such educational experiences, such as the effects of course design and the relative engagement of course participants.

  13. Ülestähendusi Birgitta festivalilt 2009 / Raili Sule

    Index Scriptorium Estoniae

    Sule, Raili, 1944-

    2009-01-01

    13.-23. augustini Pirita kloostri varemetes toimunud Tallinna Filharmoonia korraldatud Birgitta festivali raames toimunud Dmitri Bertmanni lavastustest - Umberto Giordano "Siber" ja Giuseppe Verdi "Falstaff"

  14. Cervical cancer management in Zaria, Nigeria | Sule | African ...

    African Journals Online (AJOL)

    The paper\\'s objective was to identify factors influencing cervical cancer management in Zaria with a view to improving the outcome of management. Case notes of patients managed for cervical cancer in Ahmadu Bello University Teaching Hospital (ABUTH), Zaria between January 1 1999 and December 31 2003, were ...

  15. Kadri Kõusaare skandaalne film "Magnus" sai ka Riias sule sappa

    Index Scriptorium Estoniae

    2008-01-01

    Kadri Kõusaare debüütfilmi "Magnus" linastamine Läti väärtfilmikinos Cinema Riga lõpetati, kuna kino juhtkonda ähvardati režissööri sõnul tema filmi näitamise keelustamist taotleva hageja advokaatide poolt

  16. Thermal Analysis Of Cover Plate Of Galvanizing Bath Tub At Bridge amp Roof Co. I Ltd. By Shape Modification

    Directory of Open Access Journals (Sweden)

    Anirban Jana

    2015-08-01

    Full Text Available This project is aimed for thermally analyzing stress and strain on cover plate of galvanizing bath tub at Bridge amp Roof co. I Ltd in order to maintain 450C in bath tub. Along with analysis part cover plate shape was modified due to its continuous use amp prevailing conditions at the workshop. The cover plate consist of insulating materials compacted to retain the heat in the bath tub. The thermal convection of air is less than thermal resistance of insulating materials used thus heat loss is negligible. Thermal convection air 0.0579 w m k Thermal Resistance Insulator 7.046 w m k. Thermal analysis report show at 450C. Deformation is effecting end portion 2-3 mm. Stress amp Strain at that portion is also low 0.1-0.3 Mpa. Heat transfer of air is more than insulating materials. Thus Heat transfer rate of Insulating materials being low they dont conduct heat from the bath tub to the atmosphere. So temperature of the bath tub is maintained. QA 1806.25 W Heat transfer rate of Air by convection QI 270.43 W Heat transfer rate of Insulation materials

  17. Skew scattering dominated anomalous Hall effect in Co>x(MgO)100-x granular thin films

    KAUST Repository

    Zhang, Qiang; Wen, Yan; Zhao, Yuelei; Li, Peng; He, Xin; Zhang, Junli; He, Yao; Peng, Yong; Yu, Ronghai; Zhang, Xixiang

    2017-01-01

    We investigated the mechanism(s) of the anomalous Hall effect (AHE) in magnetic granular materials by fabricating 100-nm-thick thin films of Co>x(MgO)100-x with a Co volume fraction of 34≤x≤100 using co

  18. Membranes of 5,10,15,20-Tetrakis(4-Methoxyphenyl Porphyrinatocobalt (TMOPP-Co (I as MoO42- - Selective Sensors

    Directory of Open Access Journals (Sweden)

    R. Mangla

    2002-05-01

    Full Text Available Polyvinyl chloride (PVC membrane electrodes based on porphyrin 5,10,15,20-tetrakis(4methoxyphenylporphyrinatocobalt (TMOPP-Co (I incorporating sodium tetra phenyl borate (NaTPB as anion excluder and dibutyl phthalate (DBP, dioctyl phthalate (DOP, dibutyl butyl phosphonate (DBBP, tri-n-butyl phosphate (TBP, and 1-chloronaphthalene (CN as plasticizing solvent mediators were prepared and tested for selective detection of molybdate ions. The membrane having anion excluder, NaTPB and DBP as plasticizer (membrane no. 2 proved to be best in terms of working concentration range 5.0×10-5 – 1.0×10-1M with a near – Nernstian slope of 32.0±1.0 mV/decade of activity over the pH range 5.4- 10.5. The response time of this sensor is 18s with a lifetime of about 4 months. The sensor can be used in non-aqueous medium with no significant change in the value of slope or working concentration range for the estimation of MoO42- in solutions having up to 25% (v/v non-aqueous fraction.

  19. Topotactic reduction of YBaCo2O5 and LaBaCo2O5: square-planar Co(I) in an extended oxide.

    Science.gov (United States)

    Seddon, James; Suard, Emmanuelle; Hayward, Michael A

    2010-03-03

    The low-temperature reduction of YBaCo(2)O(5) and LaBaCo(2)O(5) with NaH to form YBaCo(2)O(4.5) and YBaCo(2)O(4.25), respectively, demonstrates that the structures of anion-deficient materials formed by such topotactic reductions can be directed by the ordering and identity of the A-site cations. YBaCo(2)O(4.5) adopts a structure consisting of a corner-shared network of square-based pyramidal CoO(5) and distorted tetrahedral CoO(4) units. The structure of LaBaCoO(4.25) is more complex, consisting of an array of square-based pyramidal CoO(5), distorted tetrahedral CoO(4), and square planar CoO(4) units. Magnetic susceptibility and variable-temperature neutron diffraction data reveal that YBaCo(2)O(4.5) adopts a G-type antiferromagnetically ordered structure below T(N) approximately 280 K. LaBaCo(2)O(4.25) also adopts antiferromagnetic order (T(N) approximately 325 K) with ordered moments consistent with the presence of square-planar, low-spin, s = 0, Co(I) centers. A detailed analysis reveals that the different anion vacancy ordered structures adopted by the two REBaCo(2)O(5-x) phases are directed by the relative sizes and ordering of the La(3+) and Y(3+) cations. This suggests that ordered arrangements of A-cations can be used to direct the anion vacancy order in topotactically reduced phases, allowing the preparation of novel metal-oxygen networks containing unusual transition metal coordination environments.

  20. Three Cyanide-Bridged One-Dimensional Single Chain Co"I"I"I-Mn"I"I Complexes: Rational Design, Synthesis, Crystal Structures and Magnetic Properties

    International Nuclear Information System (INIS)

    Zhang, Daopeng; Zhao, Zengdian; Wang, Ping; Chen, Xia

    2012-01-01

    Two pyridinecarboxamide dicyanidecobalt(III) building blocks and two mononuclear seven-coordinated macrocycle manganese(II) compounds have been rationally selected to assemble cyanide-bridged heterobimetallic complexes, resulting in three cyanide-bridged Co"I"I"I-Mn"I"I complexes. Single X-ray diffraction analysis show that these complexes {[Mn(L"1)][Co(bpb)]}ClO_4·CH_3OH·0.5H_2O (1), {[Mn(L"2)][Co(bpb)]}ClO_4·0.5CH_3OH (2) and {[Mn(L"1)][Cobpmb]}ClO_4·H_2O (3) (L"1 = 3,6-diazaoctane-1,8-diamine, L"2 = 3,6-dioxaoctano-1,8- diamine: bpb"2"- = 1,2-bis(pyridine-2-carboxamido)benzenate, bpmb"2"- = 1,2-bis(pyridine-2-carboxamido)-4- methyl-benzenate) all present predictable one-dimensional single chain structures. The molecular structures of these one-dimensional complexes consists of alternating units of [Mn(L)]"2"+ (L = L"1 or L"2) and [Co(L')(CN)_2]"- (L' = bpb"2"-, or bpmb"2"-), forming a cyanide-bridged cationic polymeric chain with free ClO_4"- as the balance anion. The coordination geometry of manganese(II) ion in the three one-dimensional complexes is a slightly distorted pentagonal-bipyrimidal with two cyanide nitrogen atoms at the trans positions and N_5 or N_3O_2 coordinating mode at the equatorial plane from ligand L"1 or L"2. Investigation over magnetic properties of these complexes reveals that the very weak magnetic coupling between neighboring Mn(II) ions connected by the diamagnetic dicyanidecobalt(III) building block. A best-fit to the magnetic susceptibility of complex 1 leads to the magnetic coupling constants J = .0.084(3) cm"-"1

  1. Welding of sule elements for nuclear reactors with solid state YAG laser using instrumentated testing equipments

    International Nuclear Information System (INIS)

    Bourgault, F.; Lacoste, J.; Schley, R.; Kluzinski, C.; Piednoir, P.

    1985-09-01

    The instrumentation of the equipment for carrying out safety tests on fuel elements for nuclear reactors requires special thermocouples adapted to the prevailing agressive medium. The investigations described deal essentially with the operational and metallurgical weldability tests out on the safety test zircaloy piping in the pressurized water circuit (PHEBUS-programme) [fr

  2. Swift Ultra Long Endurance (SULE) Unmanned Air Vehicle (UAV), Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Ever since UAV's emerged as a reliable science instrument, the technology has been used to augment satellites, balloon flights, and provide spatial/resolution data...

  3. Uudised : Andresepäev eesti muusikaga. Esitleti Piazzolla plaati. Eesti luule esimene CD / Raili Sule

    Index Scriptorium Estoniae

    Sule, Raili, 1944-

    2000-01-01

    A. Marguste autorikontserdist sarjas "Eesti heliloojad talveaias" 30. nov. Argentiina restoranis esitleti CD-plaati "Tango King Astor Piazzolla". 9. dets. esitleti rahvusraamatukogus uut CD-plaati eesti luulest ja muusikast "Maa meis ja maa maailmas"

  4. Thrombocytopenia following implantation of the stentless biological sorin freedom SOLO valve.

    Science.gov (United States)

    Gersak, Borut; Gartner, Urska; Antonic, Miha

    2011-07-01

    Stentless biological valves have proven advantages in hemodynamic performance and left ventricular function compared to stented biological valves. Following a marked postoperative fall in the platelet count of patients after implantation of the Freedom SOLO valve, the study aim was to confirm clinical observations that this effect was more severe in patients receiving Freedom SOLO valves than in those receiving St. Jude Medical (SJM) mechanical aortic valves. Preoperative and postoperative platelet counts were compared in two groups of patients who underwent aortic valve replacement (AVR) without any concomitant procedures between January and December 2007. Patients received either a Freedom SOLO valve (n = 28) or a SJM mechanical valve (n = 41). Mean values of platelet counts were compared using three multiple linear regression models. Platelet counts were significantly lower in the Freedom SOLO group than in the SJM group from the first postoperative day (POD 1) up to POD 6 (p SOLO group the platelet count fell below 30x10(9)/l, while the lowest level in the SJM group was 75x10(9)/l. Based on multiple linear regression models, the type of valve implanted had a statistically significant influence on postoperative platelet counts on POD 1, POD 3, and POD 5 (p SOLO group.

  5. North American trial results at 1 year with the Sorin Freedom SOLO pericardial aortic valve.

    Science.gov (United States)

    Heimansohn, David; Roselli, Eric E; Thourani, Vinod H; Wang, Shaohua; Voisine, Pierre; Ye, Jian; Dabir, Reza; Moon, Michael

    2016-02-01

    A North American prospective, 15-centre Food and Drug Administration (FDA) valve trial was designed to assess the safety and effectiveness of the Freedom SOLO stentless pericardial aortic valve in the treatment of surgical aortic valve disease. Beginning in 2010, 251 patients (mean: 74.7 ± 7.5 years), were recruited in the Freedom SOLO aortic valve trial. One hundred eighty-nine patients have been followed for at least 1 year and are the basis for this review. Preoperatively, 54% of patients had NYHA functional class III or IV symptoms, and the majority of patients had a normal ejection fraction (EF) (median EF = 61%). Concomitant procedures were performed in 61.9% of patients, with coronary artery bypass grafting (CABG) (48.7%) being the most common followed by a MAZE procedure (13.7%). Reoperations were performed in 8.5% of patients in the study. The entire cohort of 251 patients enrolled had 7 deaths prior to 30 days, 2 of which were valve-related (aspiration pneumonia and sudden death) and 5 were not valve-related. There were 11 deaths after 30 days, 1 valve-related (unknown cardiac death) and 10 not valve-related. Five valves were explanted, 3 early (endocarditis, acute insufficiency and possible root dissection) and 2 late (endocarditis). Thirty-day adverse events include arrhythmias requiring permanent pacemaker (4.2%), thromboembolic events (3.7%) and thrombocytopenia (7.4%). One-year follow-up of all 189 patients demonstrated mean gradients for valve sizes 19, 21, 23, 25 and 27 mm of 11.7, 7.8, 6.3, 4.6 and 5.0 mmHg, respectively. Effective orifice areas for the same valve sizes were 1.2, 1.3, 1.6, 1.8 and 1.9 cm(2), respectively. Ninety-six percent of patients (181/189) were in NYHA class I or II at the 1-year follow-up. The Freedom SOLO stentless pericardial aortic valve demonstrated excellent haemodynamics and a good safety profile out to the 1 year of follow-up. © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  6. Lifetime measurements of excited Co I levels

    CERN Document Server

    Klotz, W D; Gobel, L H

    1977-01-01

    In the region of 3500 AA the lifetimes of eight excited Cobalt I levels have been measured by means of the zero field level crossing method. The measured lifetimes belong to the odd configurations 3d/sup 7/4s4p and 3d/sup 8/4p and are of the accuracy of about 5%. The hyperfine structure of levels with I not=J has to be taken into account in evaluating lifetimes from level crossing data, because the nuclear spin of the natural isotope /sup 59/Co is I=7/2. Therefore the influence of the line profile of the exciting resonance lines on the lifetimes has been investigated. The results are compared with those of other authors. Furthermore absolute oscillator strengths were calculated with known branching ratios and a new absolute scale has been established. (23 refs).

  7. Conflito por terra e água nos sules: Comunidades Huarpes (Mendoza, Argentina) e campo- neses do que hoje é Suape (Pernambuco, Brasil)

    OpenAIRE

    Solá Pérez, Mercedes; Miranda Gassull, Virginia

    2015-01-01

    Anais das IV Jornadas Internacionais de Problemas Latino-Americanos: Lutas, Experiências e Debates na América Latina - ISBN 978-950-793-223-6 - Orgs. Paulo Renato da Silva ; Mario Ayala ; Fabricio Pereira da Silva ; Fernando José Martins El artículo indaga sobre los conflictos territoriales específicos de comunidades desposeídas, entre dos casos de Argentina y Brasil. Se propone tomar los dos casos analizando a las comunidades que resisten en sus tierras tradicionalmente ocupadas, te...

  8. Uranium Adsorbent Fibers Prepared by Atom-Transfer Radical Polymerization (ATRP) from Poly(vinyl chloride)- co> -chlorinated Poly(vinyl chloride) (PVC- co> -CPVC) Fiber

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Suree; Yue, Yanfeng; Kuo, Li-Jung; Mehio, Nada; Li, Meijun; Gill, Gary; Tsouris, Costas; Mayes, Richard T.; Saito, Tomonori; Dai, Sheng

    2016-04-20

    The need to secure future supplies of energy attracts researchers in several countries to a vast resource of nuclear energy fuel: uranium in seawater (estimated at 4.5 billion tons in seawater). In this study, we developed effective adsorbent fibers for the recovery of uranium from seawater via atom-transfer radical polymerization (ATRP) from a poly- (vinyl chloride)-co-chlorinated poly(vinyl chloride) (PVC-co-CPVC) fiber. ATRP was employed in the surface graft polymerization of acrylonitrile (AN) and tert-butyl acrylate (tBA), precursors for uranium-interacting functional groups, from PVC-co-CPVC fiber. The [tBA]/[AN] was systematically varied to identify the optimal ratio between hydrophilic groups (from tBA) and uranyl-binding ligands (from AN). The best performing adsorbent fiber, the one with the optimal [tBA]/[AN] ratio and a high degree of grafting (1390%), demonstrated uranium adsorption capacities that are significantly greater than those of the Japan Atomic Energy Agency (JAEA) reference fiber in natural seawater tests (2.42-3.24 g/kg in 42 days of seawater exposure and 5.22 g/kg in 49 days of seawater exposure, versus 1.66 g/kg in 42 days of seawater exposure and 1.71 g/kg in 49 days of seawater exposure for JAEA). Adsorption of other metal ions from seawater and their corresponding kinetics were also studied. The grafting of alternative monomers for the recovery of uranium from seawater is now under development by this versatile technique of ATRP.

  9. CO I barcoding reveals new clades and radiation patterns of Indo-Pacific sponges of the family Irciniidae (Demospongiae: Dictyoceratida.

    Directory of Open Access Journals (Sweden)

    Judith Pöppe

    2010-04-01

    Full Text Available DNA barcoding is a promising tool to facilitate a rapid and unambiguous identification of sponge species. Demosponges of the order Dictyoceratida are particularly challenging to identify, but are of ecological as well as biochemical importance.Here we apply DNA barcoding with the standard CO1-barcoding marker on selected Indo-Pacific specimens of two genera, Ircinia and Psammocinia of the family Irciniidae. We show that the CO1 marker identifies several species new to science, reveals separate radiation patterns of deep-sea Ircinia sponges and indicates dispersal patterns of Psammocinia species. However, some species cannot be unambiguously barcoded by solely this marker due to low evolutionary rates.We support previous suggestions for a combination of the standard CO1 fragment with an additional fragment for sponge DNA barcoding.

  10. Use of the CO I Gene as a Species Indicator for Forensically Important Flies: A Forensic Entomology Laboratory Exercise

    Science.gov (United States)

    Honda, Jeffrey Y.

    2008-01-01

    Forensic entomologists utilize insects (particularly flies) to establish the time interval between death and body discovery. This important piece of information may answer questions as to the circumstances of the individual's death and insects are now routinely utilized and recognized as being important forensic indicators. Of extreme importance…

  11. Access to knowledge difficulties in developing countries : a balanced access to copyrighted works in the digital environment / Thipsurang Vathitphund

    Index Scriptorium Estoniae

    Vathitphund, Thipsurang

    2010-01-01

    Terve ajakiri on pühendatud materjalide kättesaamisele Internetist, juurdepääsule autoriõigusega kaitstud töödele, andmekaitsele, Googlèi teenuste kasutamisele akadeemilistes institutsioonides, videokonverentsile ning digitaalallkirjale

  12. Biosynthesis, Characterization, and Hemostasis Potential of Tailor-Made Poly(3-hydroxybutyrate-co>-3-hydroxyvalerate) Produced by Haloferax mediterranei

    DEFF Research Database (Denmark)

    Han, Jing; Wu, Linping; Hou, Jing

    2015-01-01

    . Consistently, two Tg were observed in the DSC curves of O-PHBV. The "blocky" feature of O-PHBV enhanced crystallinity percentages and improved Young's modulus. Notably, the film of one O-PHBV copolymer, O-PHBV-1, showed unique foveolar cluster-like surface morphology with high hydrophobicity and roughness...

  13. H.S.H. Prince Radu of Hohenzollern-Veringen, Special Representative of the Romanian Government for Integration, Co-operation and Sustainable Development

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    H.S.H. Prince Radu of Hohenzollern-Veringen, Special Representative of the Romanian Government for Integration, Co-operation and Sustainable Development (third from left) with (left to right) Florian Ciolacu (Romanian Mission in Geneva), Cornel Comsa (personal adviser to the Prince), Sorin Ilie (CERN), Calin Alexa (ATLAS), Iosif Legrand (Caltech/CMS), Mihaela Gheata (ALICE), Andrei Gheata (ALICE), and Sorin Zgura (ALICE).

  14. Teater

    Index Scriptorium Estoniae

    2005-01-01

    9. okt. esietendub Kanuti Gildi saalis T. Lilleoru ja K. Tõnissoni tantsulavastus "Dr. Tõrva ja professor Sule süsteem" ; Eesti Teatrikriitikute Ühendus andis VAT Teatris pärast "Klammi sõja" etendust üle järjekordse Hea Teatri auhinna, mille sai M. Vaarik. Silmas peeti viimase aja teatrirolle. Nimetatakse ka senised laureaadid

  15. Browse Title Index

    African Journals Online (AJOL)

    Items 101 - 150 of 408 ... Vol 11, No 2 (2012), Conservative breast management of breast cancer in the Niger Delta; early report of nine cases, Abstract. EA Sule. Vol 7, No 1-2 (2008), Contrast ... Vol 14, No 1 (2015), Diabetic ketoacidosis in a young Nigerian child: a case report, Abstract. IA Mbarie, EIO Woghiren. Vol 11, No 2 ...

  16. Download this PDF file

    African Journals Online (AJOL)

    De Don

    the health centres in Nigeria are treated for malaria. (Sule .... exposure, functional immunity and disease risk .... Pattern o.f. Immunoglobulin Isotype Response to Plasmodium falciparum ... Obi, T. U., Wirtz, R.A, Gordon, D. M. and Lyon J.A.,.

  17. 172 ANALYSIS OF URBAN DECAY FROM LOW RESOLUTION ...

    African Journals Online (AJOL)

    temporal pattern of urban decay in different parts of a traditional organic city through ... c. Twenty percent or more of the residential structures were in need of major ... the body of the city which must be removed through surgical blades of urban ... Figure 1. Pay-off matrix of urban blight development. (Adapted from Sule 1980).

  18. Meedikud loodavad rahumeelsele leppele / Eno-Gerrit Link

    Index Scriptorium Estoniae

    Link, Eno-Gerrit

    2007-01-01

    Tervishoiutöötajate kutseliitude esindajad võtsid väljakuulutatud streigihoiatuse maha lootuses, et kokkulepe meditsiinitöötajate miinimumtunnitasu osas võib sõlmida rahulikul teel. Arvamust avaldab Haiglate Liidu juhatuse esimees Urmas Sule

  19. Diagnostic Value of Abdominal Ultrasonography in Patients with ...

    African Journals Online (AJOL)

    where diagnostic investigations must be used to good effect, in order to determine ... Michael I Nnamonu, Chikwem H Ihezue, Augustine Z Sule, Venyir M Ramyil,. Stephen D ... There were 45 males and 12 females (M:F = 3.8:1). Ages ranged.

  20. Browse Title Index

    African Journals Online (AJOL)

    Items 551 - 600 of 818 ... A Nasir, A.J. Alhassan, M.S. Sule, A.R. Mannir, A.I. Yaradua, A Idi, I.U. ... memory and asymptomatic level of performance in Wistar rats, Abstract PDF .... waterbuck (Kubus deffasa) in Yankari game reserve, Bauchi state ...

  1. Browse Author Index

    African Journals Online (AJOL)

    Musa, Grace · Sibanda, J · Skinner-Bonat, Swanta Blessing · Sule, MA 1 - 5 of 5 Items. ISSN: 1596-6224. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

  2. Browse Title Index

    African Journals Online (AJOL)

    Items 1 - 50 of 242 ... D Dhar. Vol 2, No 2 (2003), Blood Loss And Transfusion Need During Operative Treatment Of Major Limb Fractures: Incidence And Risk, Abstract. LOA Thanni, AAA Oyelekan, GA Sule. Vol 6, No 2 (2007), Blood transfusion practices in Orthopaedic and Trauma Department in a tertiary health institution in ...

  3. Shoulder injuries in provincial male fast bowlers — predisposing ...

    African Journals Online (AJOL)

    Enrique

    sule and by the rotator cuff muscles. The external rotator strength has been reported to be around 65% of internal rotator strength.17. During bowling in cricket, the internal shoulder rotators are involved in the acceleration phase of the arm through concentric contractions, while the external rotators are involved during the ...

  4. Novõi bank v Estonii / Andrei Demenkov

    Index Scriptorium Estoniae

    Demenkov, Andrei

    2008-01-01

    14. märtsil avati Tallinnas Leedu ühe suurima panga Snoras Panga Eesti filiaal. Snoras Panga presidendi Raimondas Baranauskase, Eesti filiaali direktori Raivo Sule ja Eesti Panga presidendi Andres Lipstoki kommentaarid. Lisa. Diagrammid: Finantsteenuste turg seisuga 30.06.2007

  5. Browse Title Index

    African Journals Online (AJOL)

    Items 501 - 550 of 831 ... MA Misauno, AZ Sule, SD Pam, SC Ideke, GI Achinge. Vol 21, No 3 (2012), Pattern of Eye Diseases in a University Health Service Clinic in Northern Nigeria, Abstract. KK Oladigbolu, ER Abah, D Chinda, EE Anyebe. Vol 16, No 3 (2007), Pattern of geriatric otolaryngological diseases in Port Harcourt ...

  6. Highland Medical Research Journal - Vol 14, No 2 (2014)

    African Journals Online (AJOL)

    Knowledge of malaria and practice of home management of malaria among mothers of under fives · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. ZI Hassan, TO Afolaranmi, YO Tagurum, HA Agbo, HM Sule, 58-62 ...

  7. Agreement on trade-related aspects of intellectual property rights and access to medication: does Egypt have sufficient safeguards against potential public health implications of the agreement / Heba Wanis

    Index Scriptorium Estoniae

    Wanis, Heba

    2010-01-01

    Intellektuaalomandi Õiguste Kaubandusaspektide Lepingust (TRIPS Agreement) ja selle mõjust ravimitele juurdepääsule Egiptuses. Ülevaade ravimitööstusest, ravimitele juurdepääsu põhiteguritest ning ravimite ja tervishoiu olukorrast

  8. Reificação e consumismo ostentatório no Gatsby O Magnifíco> Reification and consumerism in The Great Gatsby

    Directory of Open Access Journals (Sweden)

    Robert Sayre

    2007-05-01

    Full Text Available Trata-se de uma interpretação do romance Gatsby, o Magnífico, de F. Scott Fitsgerald, a partir de aspectos essenciais da sociedade moderna, como a reificação e o consumo ostentatório, aspectos esses intimamente ligados e relativamente distintos. Trata-se, portanto de destacar algumas modalidades importantes de conhecimento sui generis desses fenômenos, exclusivamente, pelos meios literários. Palavras-chave: Alienação. Classe ociosa. Reificação. Literatura. This paper is a sociological interpretation of the novel The Great Gatsby, by F. Scott Fitsgerald, from the point of view of some of the essential aspects of modern society such as the reification and the boasting consume which are at the same time closely linked and relatively distinct. In fact, it tries to point out some important modalities of human knowledge through a literary form, the novel. Keywords: Alienation. Idle class. Literature. Reification.

  9. EVALUATION OF GENETIC VARIABILITY OF FRESHWATER PRAWN COLLECTED FROM MAKASSAR-SULAWESI, PANGKALANBUNKALIMANTAN, JAMBI-SUMATRA, SUKABUMI-JAVA, AND GIMacro USING mtDNA CO-I MARKERS

    Directory of Open Access Journals (Sweden)

    Estu Nugroho

    2009-06-01

    Full Text Available The objective of this research is to evaluate the genetic variability of freshwater prawn, Macrobrachium rosenbergii. The genetic variability of freshwater prawn collected from Makassar-Sulawesi, Pangkalanbun-Kalimantan, Jambi-Sumatra, Sukabumi-Java, and GIMacro strain was examined using polymorphism of the mitochondria DNA (mtDNA markers. Twelve composite haplotypes were detected following digestion of CO1 sequences with four endonucleases: Hae III, Rsa I, Mbo I, and Taq I. The average haplotype diversity was 0.217. Significant genetic difference was observed among freshwater prawn populations, especially among Makassar-Sulawesi population and others. Makassar-Sulawesi strain has future prospect for genetic resources in breeding program.

  10. Arstiabi mainet rikub sage sõnasõda / Kadri Ibrus

    Index Scriptorium Estoniae

    Ibrus, Kadri

    2006-01-01

    Tervishoiekspert Maris Jesse sõnul on rahva usaldus arstiabi vastu kahanemas. Selle üheks põhjuseks peab ta tervishoiujuhtide pidevaid avalikke tülisid raha pärast, mis loob ebakindla olukorra ja peletab arste-õdesid välismaale tööle. Haiglate liidu juhatuse esimehe Urmas Sule kommentaare. Lisa: Arstide lahkumine ei olnud üllatav

  11. Aortic Valve Replacement With the Stentless Freedom SOLO Bioprosthesis: A Systematic Review

    NARCIS (Netherlands)

    Wollersheim, Laurens W.; Li, Wilson W.; Bouma, Berto J.; Repossini, Alberto; van der Meulen, Jan; de Mol, Bas A.

    2015-01-01

    This systematic review examined the clinical and hemodynamic performance of the stentless Freedom SOLO (Sorin Group, Milan, Italy) aortic bioprosthesis. The occurrence of postoperative thrombocytopenia was also analyzed. The Freedom SOLO is safe to use in everyday practice, with short cross-clamp

  12. Progesterone radioimmunoassay

    International Nuclear Information System (INIS)

    Stroufova, A.; Kozlova, J.

    1976-01-01

    RIA methods of determining progestorone using the SORIN kit made in Italy and the NEN kit made in Great Britain were compared. Plasma extraction, the initial sample size for examination and recovery, the range of calibration curves of the two kits, the variation coefficient, the values of the blank sample and the values of progesterone determined in the normal menstrual cycle are discussed in detail. Variation coefficient: Sorin (calibration curve 9 to 11%, biological material 9.2%), NEN (calibration curve 12%, biological material 27.8%); determinations of progesterone levels during a normal menstrual cycle were 10 to 15% higher with the NEN kit; tritiated samples were measured with a 30 to 37% efficiency using the SORIN kit and 15 to 18% efficiency using the NEN kit. The turbidity and later sediment which formed during the determination of steroid hormones in biological materials after the addition of the scintillation solution did not reduce the efficiency of measurement. Priority is given to the SORIN kit. (L.O.)

  13. Film Diegost - kriitikavaba kummardus / Andres Must

    Index Scriptorium Estoniae

    Must, Andres

    2007-01-01

    PÖFFi filme - Argentiina mängufilm legendaarse jalgpalluri Diego Maradona jumaldamisest "Teel Maradona juurde" ("El camino de San Diego") : stsenarist ja režissöör Carlos Sorin. Artikkel on peamiselt Maradonast, vähesel määral filmist

  14. Comparison between traditional and goal directed perfusion in cardiopulmonary by-pass. Adaptation of a differential cost analysis

    Directory of Open Access Journals (Sweden)

    Massimiliano Povero

    2015-10-01

    Full Text Available BACKGROUND: A previous patient-level discrete event simulation (DES model was developed to perform an economic evaluation of GDP strategy with respect to TP in US. Aim of this supplement is provide results of the adaptations of the differential cost analysis to Belgium, Canada, France, Germany, Italy, and UK. METHODS: A Discrete Event Simulation model was developed to compare TP and GDP strategy in patients undergoing CPB. National perspective was adopted to calculate costs associated to each event while GDP strategy was exploited the introduction of Sorin Heartlink (HL Card/GDP Card and Sorin Connect (electronic data management system. RESULTS: GDP reduces the total cost with respect to traditional perfusion; furthermore the cost of GDP strategy (Sorin GDPTM Monitor and Sorin ConnectTM is completely offset by the saving in hospital stay. CONCLUSION: GDP seems to improve significantly the main outcomes related to CPB surgery, when compared to TP techniques. Additional costs due to perform GDP strategy have no impact on the total cost since completely offset by the savings in hospital cost.

  15. Tuning the composition of metastable Co<i>xNiyMg100−xy(OH)(OCH3) nanoplates for optimizing robust methane dry reforming catalyst

    DEFF Research Database (Denmark)

    Fan, Xiaoli; Liu, Zhiting; Zhu, Yi-An

    2015-01-01

    of the metastable precursor CoxNiyMg100−x−y(OH)(OCH3) derived from solvothermal synthesis. The catalyst composition and reaction conditions have been modulated to achieve maximum coke resistance and catalyst stability. Long-term stability for 1000 h time on stream at 800°C has been achieved for the optimized Co0.......075Ni7.425Mg92.5O catalyst. The role of Co in the catalyst has been disclosed through kinetic measurements and detailed characterization of the spent catalysts. Co is enriched on the Co–Ni alloy surface under reforming conditions and accelerates the gasification of coke intermediates. Co also enhances...

  16. No evidence for an early seventeenth-century Indian sighting of Kepler's supernova (SN1604)

    Science.gov (United States)

    van Gent, R. H.

    2013-03-01

    In a recent paper in this journal, Sule et al. (2011) argued that an early 17th-century Indian mural of the constellation Sagittarius with a dragon-headed tail indicated that the bright supernova of 1604 was also sighted by Indian astronomers. In this paper it will be shown that this identification is based on a misunderstanding of traditional Islamic astrological iconography and that the claim that the mural represents an early 17th-century Indian sighting of the supernova of 1604 has to be rejected.

  17. Commission 22: Meters, Meteorites and Interplanetary Dust

    Science.gov (United States)

    Watanabe, Junichi; Jenniskens, Peter; Spurný, Pavel; Borovička, Jiří; Campbell-Brown, Margaret; Consolmagno, Guy; Jopek, Tadeusz; Vaubaillon, Jeremie; Williams, Iwan P.; Zhu, Jin

    2010-05-01

    The business meeting of commission 22 was held at the room 5 in the SulAmerica Convention Center in Rio de Janeiro(14:00-15:30). Fifteen people attended at this meeting:J.Borovička, E.Bowell, G.Consolmagno, D.Green, P. Jenniskens, A. Pellinen-Wannberg, R. Rudawska, J. Watanabe, J. Zhu, P. H. A. Hasselmann, F. Ostroviski, D. A. Oszkiewicz, W. Thuillot, P. Mahajani, and A. Sule. This meeting was managed by Junichi Watanabe, the current C22 Vice-President. The summary of the meeting is described.

  18. Design Methodologies for Secure Embedded Systems

    CERN Document Server

    Biedermann, Alexander

    2011-01-01

    Embedded systems have been almost invisibly pervading our daily lives for several decades. They facilitate smooth operations in avionics, automotive electronics, or telecommunication. New problems arise by the increasing employment, interconnection, and communication of embedded systems in heterogeneous environments: How secure are these embedded systems against attacks or breakdowns? Therefore, how can embedded systems be designed to be more secure? And how can embedded systems autonomically react to threats? Facing these questions, Sorin A. Huss is significantly involved in the exploration o

  19. Ethno-Confessional Realities in the Romanian Area: Historical Perspectives (XVIII-XX centuries)

    OpenAIRE

    Brie, Mircea; Şipoş, Sorin; Horga, Ioan

    2011-01-01

    Ethno-Confessional Realities in the Romanian Area: Historical Perspectives (XVII-XX Centuries) This present collective volume, coordinated by Mircea Brie, Sorin Şipoş and Ioan Horga, contains the papers of the international conference Ethnicity, Confession and Intercultural Dialogue at the European Union’s East Border (workshop: Ethno-Confessional Realities in the Romanian Area: Historical Perspectives), held in Oradea between 2nd-5th of June 2011. This international conference, organized...

  20. Delta infection evidenced by radioimmunoanalysis in selected collectives

    Energy Technology Data Exchange (ETDEWEB)

    Kselikova, M; Horejsi, J; Urbankova, J

    1987-01-01

    The presence of the Delta agent within the population was tested by means of the Delta-antibody radioimmunoassay using competitive kits of the firms ABBOTT (ABBOTT-ANTI-DELTA) and SORIN (AB-DELTAK). The Delta-antibody was found in 3.2% HBV patients, 5% HBsAg carriers, and in 20.8% of specific anti-Hbs-immunoglobulin. In hemophiliacs and blood donors no Delta-antibody was seen.

  1. Delta infection evidenced by radioimmunoanalysis in selected collectives

    International Nuclear Information System (INIS)

    Kselikova, M.; Horejsi, J.; Urbankova, J.

    1987-01-01

    The presence of the Delta agent within the population was tested by means of the Delta-antibody radioimmunoassay using competitive kits of the firms ABBOTT (ABBOTT-ANTI-DELTA) and SORIN (AB-DELTAK). The Delta-antibody was found in 3.2% HBV patients, 5% HBsAg carriers, and in 20.8% of specific anti-Hbs-immunoglobulin. In hemophiliacs and blood donors no Delta-antibody was seen. (author)

  2. Multicentric Evaluation of New Commercial Enzyme Immunoassays for the Detection of Immunoglobulin M and Total Antibodies against Hepatitis A Virus▿

    Science.gov (United States)

    Arcangeletti, M. C.; Dussaix, E.; Ferraglia, F.; Roque-Afonso, A. M.; Graube, A.; Chezzi, C.

    2011-01-01

    A multicentric clinical study was conducted on representative sera from 1,738 European and U.S. subjects for the evaluation of new anti-hepatitis A virus enzyme immunoassays from Bio-Rad Laboratories. Comparison with reference DiaSorin S.p.A. tests confirmed the good performance of Bio-Rad assays (99.85% and 99.47% overall agreement in detecting total antibodies and IgM, respectively). PMID:21653739

  3. După 25 de ani. Comunismul din Europa de Est (iunie-decembrie 2014 (After 25 years. Communism in Eastern Europe (June – December 2014

    Directory of Open Access Journals (Sweden)

    Adrian TOMPEA

    2015-03-01

    Full Text Available The project „After 25 years. Communism in Eastern Europe”, organized by the Faculty of Political Sciences from “Petre Andrei” University from Iasi, The Institute for The Study of Ideologies and Polis Journal in collaboration with The European Institute Publishing House and with prestigious cultural publications from Romania, coordinated by Prof. Ph.D. Sorin Bocancea, has continued with its activities from June to December 2014. The activities were: the debate The students’ humor in communist Romania; the round table conference 23 August after 70 years; the debate The Romanian press from communism to post-communism (coordinator Sorin Bocancea; the seminar Literature and ideology. In the shadows of socialist realism; the conference The soviet underground; alternative music from 1945 – 1991, held by the writer Vasile Ernu; the varnishing of the exposition The History of the Cold War; the opening of the Library of Memoirism belonging to the Faculty of Political and Administrative Sciences; the debate Exiled among brothers; the varnishing of the exposition The Wall. A border inside Germany; the international conference 25 years from the fall of the Berlin Wall; the launching of the book This is how we have spent the Revolution, event organized by Sorin Bocancea and Mircea Muresan. Within the project, during 2015, another six books will be published by The European Institute Publishing House.

  4. Uus Eesti disain / Silvia Pärmann

    Index Scriptorium Estoniae

    Pärmann, Silvia

    2016-01-01

    Allan Prooso, Argo Männiku ja Kalmer Alliku (HOOG) disainitud riiulid. Liis Lindmaa ja Anatoli Tafitšuki disainitud kassimaja Juno. Anni Varmi puidust lõikelauad, Toivo Raidmetsa tool Arike, Maria Kalmu vineerist prossid, Jaanus Orgusaare kapp Rolling. Merili Sule ja Petrica Artene (StenCilit) disainitud seinašabloonid. Merlin Tiiveli (NION design) käsitsi valmistatud sisustuaksessuaarid (korvid, vaibad, kott-toolid). Margus Triibmanni toolvalgusti Cranberry, Stella Soomlaisi naturaalsest nahast käekotid. Kristjan Rabi, Janno Roodi, Veljo Viikanti (Aegaon) disainitud käekellad. Mari Saani, Mariana Laane (stuudio Nüüd) keraamika. Silver Tibbingi pakendikujundused Sõsara kosmeetikatoodetele, Elena Volki ja Eveliis Salaka Helge Kodu ruumiparfüümid. Kerly Kaljuste ja Anu Rajamäe (KOOSdisain) kodutekstiilid. Meelis Undi ja Mari Otsa (WolfBerry) lastemööbel

  5. Detection of In Vitro Antimalarial Activity of Some Myanmar Medicinal Plants

    Energy Technology Data Exchange (ETDEWEB)

    Ei, Shun Lai; Mon, Hla Myat; Myint, Khin Htay

    2008-06-15

    In order to find out the novel effective antimalarials. six medicinal plants, namely Erythrina stricta Roxb. (Kathit), Luffa acutangula Roxb. (Thabut - Kja), Cordia rothii Roem. and Schult. (Thanet), Tribulus terrestris Linn. (Sule). Zizphus oenoplia Mill. (Paung - pe) and Mimusops elengi Roxb. (Khaye) were selected and tested for their antimalarial activity by using in vitro microdilution technique. According to the in vitro test results, Erythrina stricta Roxb. (Kathit) was found to possess significant suppressive effect on Plasmodium falciparum. With the serially diluted extract dosage concentrations ranging from 1.250 ng/ml to 40,000 ng/ml, the schizont suppressive percentage of Eryhrina stricta Roxb. (Kathi) was observed to be 19.57%, 35.44%, 55.18%, 96.04%,100% and 100% respectively.

  6. Detection of In Vitro Antimalarial Activity of Some Myanmar Medicinal Plants

    International Nuclear Information System (INIS)

    Shun Lai Ei; Hla Myat Mon; Khin Htay Myint

    2008-06-01

    In order to find out the novel effective antimalarials. six medicinal plants, namely Erythrina stricta Roxb. (Kathit), Luffa acutangula Roxb. (Thabut - Kja), Cordia rothii Roem. and Schult. (Thanet), Tribulus terrestris Linn. (Sule). Zizphus oenoplia Mill. (Paung - pe) and Mimusops elengi Roxb. (Khaye) were selected and tested for their antimalarial activity by using in vitro microdilution technique. According to the in vitro test results, Erythrina stricta Roxb. (Kathit) was found to possess significant suppressive effect on Plasmodium falciparum. With the serially diluted extract dosage concentrations ranging from 1.250 ng/ml to 40,000 ng/ml, the schizont suppressive percentage of Eryhrina stricta Roxb. (Kathi) was observed to be 19.57%, 35.44%, 55.18%, 96.04%,100% and 100% respectively

  7. Componentes para una renovada teoría de la renta

    Directory of Open Access Journals (Sweden)

    Cuevas Homero

    1995-12-01

    Full Text Available

    I. DEFICIENCIAS DE LA TEORÍA CLASICA DE LA RENTA

    1.1 El sistema de Ricardo legó una teoría de la renta con un alto grado de generalidad y consistencia, quiza mayor del que sule reconocérsele, lo cual parece evidente cuando se dejan de lado ciertas simplificaciones expositivas del capítulo II de los Principios y se enfrenta a la complejidad del modelo íntegro desarrollado en el capítulo XXIV. Esta complejidad descansa, a su vez en la interrelación de unas pocas lineas muy sólidas, las cuales se identifican a continuación (1.2 a 1.7.

  8. Desalinasi Air Laut Berbasis Energi Surya Sebagai Alternatif Penyediaan Air Bersih

    Directory of Open Access Journals (Sweden)

    I Gede Yogi Dewantara

    2018-03-01

    Full Text Available Penelitian ini berkonsentrasi pada kemampuan alat desalinasi tipe solar still dalam menyerap energi kalor matahari dan penggunaannya dalam proses kondensasi guna memproduksi air tawar untuk keperluan masyarakat. Alat desalinasi ini terdiri dari kotak distiller dengan plat absorber dan kain yang terdapat di dalamnya, serta kaca sebagai pentransmisian. Sistem kerja berawal dari air diteteskan melalui pipa dan jatuh pada kain yang akan menyerap air. Radiasi matahari akan memanaskan plat absober melalui kaca kemudian panas plat memanaskan air pada kain hingga menjadi uap dan menempel pada permukaan dalam kaca hingga terkonsensasi menjadi air suling. Pengukuran volume minimal dan maksimal alat sebesar 5 lt dan 7 lt dilakukan selama 4 hari. Melalui penelitian ini dapat disimpulkan bahwa intensitas matahari telah ada saat cahaya matahari mulai terlihat pada pukul 6 pagi dan difusi energi kalor matahari telah mulai dimanfaatkan pada waktu tersebut. Akan tetapi kinerja alat desalinasi masih sangat rendah, hal ini terlihat dari angka efisiensi yang hanya mencapai 4,45%.

  9. Comparison of Sequential Regimen and Standard Therapy for Helicobacter pylori Eradication in Patients with Dyspepsia

    Directory of Open Access Journals (Sweden)

    Gh. Roshanaei

    2013-10-01

    Full Text Available Introduction & Objective: Some studies have reported successful eradication rates using se-quential therapy but more recent studies performed in Asia did not find a similar benefit. Due to inconsistencies in the comparison of standard triple drugs therapy and sequential regimen, in the previous researches we decided to compare these treatments in Persian patients. Materials & Methods: This study is a randomized clinical trial, performed in one hundred and forty patients suffering from dyspepsia with indication for H. pylori eradication between No-vember 2010 and March 2012.Patients were randomized in two equal groups. The patients in the first group (standard were treated by omeprazole capsule 20 mg BID, amoxicillin cap-sule 1 gr BID, clarithromycin tablet 500mg BID for 14 days; while the patients in the second group (sequential were treated by omeprazole capsule 20 mg for 10 days, amoxicillin cap-sule 1 gr BID for 5 days, then clarithromycin tablet 500 mg and tinidazole tablet 500 mg BID for other 5 days. 4-6 weeks after the treatment, we compared the eradication of H.pylori be-tween the two groups by urease breathe test with C14. Results: H. pylori infection was successfully cured in 57/70 (81.43% with a 10-day sequen-tial therapy, in 60/70 (85.75% with the standard fourteen-day triple therapy, respectively. Conclusion: We detected no significant differences between the 10-day sequential eradication therapy for H. pylori and 14-day standard triple treatment among the patients. (Sci J Hamadan Univ Med Sci 2013; 20 (3:184-193

  10. Influence of type of aortic valve prosthesis on coronary blood flow velocity.

    Science.gov (United States)

    Jelenc, Matija; Juvan, Katja Ažman; Medvešček, Nadja Tatjana Ružič; Geršak, Borut

    2013-02-01

    Severe aortic valve stenosis is associated with high resting and reduced hyperemic coronary blood flow. Coronary blood flow increases after aortic valve replacement (AVR); however, the increase depends on the type of prosthesis used. The present study investigates the influence of type of aortic valve prosthesis on coronary blood flow velocity. The blood flow velocity in the left anterior descending coronary artery (LAD) and the right coronary artery (RCA) was measured intraoperatively before and after AVR with a stentless bioprosthesis (Sorin Freedom Solo; n = 11) or a bileaflet mechanical prosthesis (St. Jude Medical Regent; n = 11). Measurements were made with an X-Plore epicardial Doppler probe (Medistim, Oslo, Norway) following induction of hyperemia with an adenosine infusion. Preoperative and postoperative echocardiography evaluations were used to assess valvular and ventricular function. Velocity time integrals (VTI) were measured from the Doppler signals and used to calculate the proportion of systolic VTI (SF), diastolic VTI (DF), and normalized systolic coronary blood flow velocities (NSF) and normalized diastolic coronary blood flow velocities (NDF). The systolic proportion of the LAD VTI increased after AVR with the St. Jude Medical Regent prosthesis, which produced higher LAD SF and NSF values than the Sorin Freedom Solo prosthesis (SF, 0.41 ± 0.09 versus 0.29 ± 0.13 [P = .04]; NSF, 0.88 ± 0.24 versus 0.55 ± 0.17 [P = .01]). No significant changes in the LAD velocity profile were noted after valve replacement with the Sorin Freedom Solo, despite a significant reduction in transvalvular gradient and an increase in the effective orifice area. AVR had no effect on the RCA flow velocity profile. The coronary flow velocity profile in the LAD was significantly influenced by the type of aortic valve prosthesis used. The differences in the LAD velocity profile probably reflect differences in valve design and the systolic transvalvular flow pattern.

  11. The nuclear, an efficient tool against global warming

    International Nuclear Information System (INIS)

    2009-01-01

    Proposing and commenting some extracts of a book by Francis Sorin (Le nucleaire et la planete), this document aims at showing that nuclear energy production is a tool to struggle against global warming because of its low carbon emission. Some assessments of this characteristic are given and discussed, as well as figures on carbon emissions in different western countries. This document also criticises the statements made by ecologists against nuclear energy. The author put nuclear energy at the same level as energy savings and renewable energies, as means to reach the desirable CO 2 saving level

  12. Resultados del recambio valvular pulmonar según el tipo de prótesis implantada

    Directory of Open Access Journals (Sweden)

    María García Vieites

    2017-05-01

    Conclusiones: El RVP en nuestra serie se ha asociado a una baja tasa de mortalidad perioperatoria. Cuando comparamos según el tipo de prótesis, la prótesis Medtronic Freestyle presentó un mayor gradiente inicial y en el grupo Sorin Soprano se observa una degeneración protésica superior a la esperada. Sin embargo, será necesario más seguimiento para definir el comportamiento de la prótesis Carpentier Edwards.

  13. Performance of the Epstein-Barr Virus and Herpes Simplex Virus Immunoglobulin M Assays on the Liaison Platform with Sera from Patients Displaying Acute Parvovirus B19 Infection▿

    Science.gov (United States)

    Costa, Elisa; Tormo, Nuria; Clari, María Ángeles; Bravo, Dayana; Muñoz-Cobo, Beatriz; Navarro, David

    2009-01-01

    Acute parvovirus B19 infection has been reported to cause false-positive results frequently in the Epstein-Barr (EBV) and herpes simplex virus (HSV) immunoglobulin M (IgM) assays from DiaSorin performed on the Liaison platform. We tested 65 sera from patients with a presumptive or conclusive diagnosis of acute parvovirus B19 infection in both assays and obtained no false-positive results in the EBV IgM test and 10.4% nonspecific reactivities in the HSV IgM assay. Our data support the specificity of both assays in this clinical setting. PMID:19571110

  14. Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.

    Science.gov (United States)

    Gallicchio, Lisa; Helzlsouer, Kathy J; Chow, Wong-Ho; Freedman, D Michal; Hankinson, Susan E; Hartge, Patricia; Hartmuller, Virginia; Harvey, Chinonye; Hayes, Richard B; Horst, Ronald L; Koenig, Karen L; Kolonel, Laurence N; Laden, Francine; McCullough, Marjorie L; Parisi, Dominick; Purdue, Mark P; Shu, Xiao-Ou; Snyder, Kirk; Stolzenberg-Solomon, Rachael Z; Tworoger, Shelley S; Varanasi, Arti; Virtamo, Jarmo; Wilkens, Lynne R; Xiang, Yong-Bing; Yu, Kai; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Abnet, Christian C; Albanes, Demetrius; Bertrand, Kimberly; Weinstein, Stephanie J

    2010-07-01

    The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP), a consortium of 10 prospective cohort studies from the United States, Finland, and China, was formed to examine the associations between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of rarer cancers. Cases (total n = 5,491) included incident primary endometrial (n = 830), kidney (n = 775), ovarian (n = 516), pancreatic (n = 952), and upper gastrointestinal tract (n = 1,065) cancers and non-Hodgkin lymphoma (n = 1,353) diagnosed in the participating cohorts. At least 1 control was matched to each case on age, date of blood collection (1974-2006), sex, and race/ethnicity (n = 6,714). Covariate data were obtained from each cohort in a standardized manner. The majority of the serum or plasma samples were assayed in a central laboratory using a direct, competitive chemiluminescence immunoassay on the DiaSorin LIAISON platform (DiaSorin, Inc., Stillwater, Minnesota). Masked quality control samples included serum standards from the US National Institute of Standards and Technology. Conditional logistic regression analyses were conducted using clinically defined cutpoints, with 50-<75 nmol/L as the reference category. Meta-analyses were also conducted using inverse-variance weights in random-effects models. This consortium approach permits estimation of the association between 25(OH)D and several rarer cancers with high accuracy and precision across a wide range of 25(OH)D concentrations.

  15. Annular dynamics of memo3D annuloplasty ring evaluated by 3D transesophageal echocardiography.

    Science.gov (United States)

    Nishi, Hiroyuki; Toda, Koichi; Miyagawa, Shigeru; Yoshikawa, Yasushi; Fukushima, Satsuki; Yoshioka, Daisuke; Sawa, Yoshiki

    2018-04-01

    We assessed the mitral annular motion after mitral valve repair with the Sorin Memo 3D® (Sorin Group Italia S.r.L., Saluggia, Italy), which is a unique complete semirigid annuloplasty ring intended to restore the systolic profile of the mitral annulus while adapting to the physiologic dynamism of the annulus, using transesophageal real-time three-dimensional echocardiography. 17 patients (12 male; mean age 60.4 ± 14.9 years) who underwent mitral annuloplasty using the Memo 3D ring were investigated. Mitral annular motion was assessed using QLAB®version8 allowing for a full evaluation of the mitral annulus dynamics. The mitral annular dimensions were measured throughout the cardiac cycle using 4D MV assessment2® while saddle shape was assessed through sequential measurements by RealView®. Saddle shape configuration of the mitral annulus and posterior and anterior leaflet motion could be observed during systole and diastole. The mitral annular area changed during the cardiac cycle by 5.7 ± 1.8%.The circumference length and diameter also changed throughout the cardiac cycle. The annular height was significantly higher in mid-systole than in mid-diastole (p 3D ring maintained a physiological saddle-shape configuration throughout the cardiac cycle. Real-time three-dimensional echocardiography analysis confirmed the motion and flexibility of the Memo 3D ring upon implantation.

  16. The Image of Transylvania in the Works of Two Contemporary Romanian Historians. Translation and Related Views on History

    Directory of Open Access Journals (Sweden)

    Lajos Katalin

    2017-09-01

    Full Text Available “As every inhabited area, culturally Transylvania can also be conceived of mainly as a symbolic space. Starting from its physical, material reality, our perceptions are made up into a subjective image of the area in question. This is the real Transylvania, or rather, the place in connection with which we formulate our ideas and to which we adjust our deeds. This image may seem so real also because it is equally shared by many, occasionally several millions. If many see things in the same way, we could say, this means that they are so in reality, though most of the time we only share prejudices, clichés and misunderstandings” - Sorin Mitu writes. Comparative imagology examines the formation of these collective ideas as well as the issues of identity and attitude to the Other. As a member of the imagology research group at the Department of Humanities of Sapientia Hungarian University of Transylvania, Miercurea Ciuc, Romania, I translated one chapter of Sorin Mitu’s volume entitled Transilvania mea [My Transylvania]. During the translation process it became obvious to me that if translation is not only linguistic but also cultural transmission, it is especially true for the translation of historical works and that it would be worth examining whether some kind of rapprochement could be detected between the Romanian and Hungarian historical research of the past decades; if yes, whether this is reflected in the mutual translation of the respective works

  17. Defining directors’ conflict of interests in code of ethics

    Directory of Open Access Journals (Sweden)

    Emiliano Di Carlo

    2011-04-01

    Full Text Available We propose a definition of directors’ conflict of interests (CoI by critically reviewing the academic literature. Then, we present an exploratory study, based on a content analysis of the leading Italian listed companies that sought to empirically assess the directors’ CoI definitions provided by corporate codes of ethics. We found that despite the presence of CoI statement within corporate codes of ethics, CoI definition is often absent, when present it is not always clear, and differs widely among firms. The consequence is that CoI recognition could be not easy and remedies to prevent and resolve directors’ CoI lose their practical utility.

  18. Practical Applications of Short-Lived Radionuclides in Activation Analysis; Applications Pratiques des Radioelements de Courte Periode dans l'Analyse par Activation; ПРАКТИЧЕСКОЕ ПРИМЕНЕНИЕ КОРОТКОЖИВУЩИХ РАДИОИЗОТОПОВ ПРИ АКТИВАЦИОННОМ АНАЛИЗЕ; Aplicaciones Practicas de los Radionuclidos de Periodo Corto en el Anausis por Activacion

    Energy Technology Data Exchange (ETDEWEB)

    Chinaglia, B. Chin; Ciuffolotti, L.; Fasolo, G. B.; Malvano, R. [Centre de Recherches Nucleaires Sorin, Saluggia (Italy)

    1963-03-15

    Activation analysis by means of short-lived radionuclides has found some remarkable applications in the SORIN Research Centre at Saluggia. The paper describes the special techniques of irradiation, chemical separation and measurement required to obtain adequate accuracy and good sensitivity. It has proved possible to apply the method to analysis of elements with a half-life down to 10 s, with a consequent enormous gain in time. The method has been of benefit in several different spheres, as in solving metallurgical and technical problems (e.g. study of impurities in special-purpose materials) and in geochemistry and biology. (author) [French] L'analyse par activation au moyen de radioelements de courte periode a trouve de remarquables applications au Centre de recherches SORIN, a Saluggia. On decrit dans le memoire les techniques particulieres d'irradiation, de separation chimique et de mesure qui sont indispensables pour obtenir une precision satisfaisante ainsi qu'une bonne sensibilite. On a pu ainsi etendre la methode a l'analyse dfelements dont la periode peut atteindre dix secondes, realisant de cette facon un remarquable gain de temps. Plusieurs branches ont tire profit de cette methode, soit dans la resolution de problemes metallurgiques et technologiques (par exemple etude des impuretes dans des materiaux d'emploi special), soit en geochimie et en biologie. (author) [Spanish] El analisis por activacion empleando radionuclidos de periodo corto ha encontrado aplicaciones notables en el Centro de Investigaciones SORIN de Saluggia. En la memoria se describen tecnicas especiales de irradiacion, de separacion quimica y de medicion, indispensables para alcanzar una precision y sensibilidad satisfactorias. Se han podido analizar elementos de un periodo de hasta 10 s, logrando asi un considerable ahorro de tiempo. El metodo ha beneficiado a muchos campos de aplicacion, sea para resolver problemas de metalurgia y technologia (por ejemplo en el estudio de las

  19. Cardioplegia heat exchanger design modelling using computational fluid dynamics.

    Science.gov (United States)

    van Driel, M R

    2000-11-01

    A new cardioplegia heat exchanger has been developed by Sorin Biomedica. A three-dimensional computer-aided design (CAD) model was optimized using computational fluid dynamics (CFD) modelling. CFD optimization techniques have commonly been applied to velocity flow field analysis, but CFD analysis was also used in this study to predict the heat exchange performance of the design before prototype fabrication. The iterative results of the optimization and the actual heat exchange performance of the final configuration are presented in this paper. Based on the behaviour of this model, both the water and blood fluid flow paths of the heat exchanger were optimized. The simulation predicted superior heat exchange performance using an optimal amount of energy exchange surface area, reducing the total contact surface area, the device priming volume and the material costs. Experimental results confirm the empirical results predicted by the CFD analysis.

  20. Synthesis of the panel information principles for nuclear regulators: the journalist's view

    International Nuclear Information System (INIS)

    Lippman, T.W.

    1994-01-01

    The four journalists who participated in the OECD Nuclear Energy Agency seminar were M. Thomas Lippman, United States; Ms. Anna Schytt, Sweden; M. Michel Lemeret, Belgium; and M. Francis Sorin, France. Although the nuclear industry is structured differently in each of these countries, the journalists who have written about it for many years agreed on certain basic points. In order to have the confidence of the public, nuclear regulators must function openly, provide accurate and dispassionate information, have a reservoir of available technical knowledge and be independent of government and politics. Their purpose should be to regulate, rather than to promote the nuclear energy industry. The participants agreed that it is part of the regulators' role to provide information to the public on a regular basis, to forestall misunderstanding and potential panic. But this must be done in a way that does not appear to be promoting the nuclear power industry as such. (author)

  1. RIA of alpha-fetoprotein in serum and amniotic fluid

    International Nuclear Information System (INIS)

    Fingerova, H.; Talas, M.; Stroufova, A.

    1979-01-01

    An own modification of the double antibody radioimmunoassay for AFP using 125 I-labelled AFP as a tracer, rabbit anti-AFP obtained from SEVAC, Prague and precipitating antibodies prepared by the authors is described. The AFP levels measured in the serum and the amniotic fluid using the method were in agreement with those obtained by the means of the AFPK RIA kit by SORIN in the Institute for the Care of Mother and Child in Prague. The AFP concentrations found in the cord serum and the amniotic fluid were confirmed also by the rocket electroimmunoassay according to Laurell. The described AFP RIA seems suitable for the clinical application in prenatal screening for congenital malformations, in difficult pregnancies, in hepatology and the diagnosis and the evaluation of therapy of some human malignancies. (author)

  2. Ispra joint research center in the field of shielding; Attivita del C.C.R. di Ispra nel campo delle schermature

    Energy Technology Data Exchange (ETDEWEB)

    Kind, A.; Nicks, R.

    1963-07-01

    In the field of shielding nuclear energy plants certain problems of outstanding importance still require satisfactory solutions. Among these, particular importance is assumed by that of determining removal of sections for fission neutrons and that of calculating the propagation of neutrons and gamma rays by means of penetrations. On behalf of the Reactor Physics Department of Ispra, theoretical as well as practical research in this direction has been undertaken rather a long time ago. Two contracts have been concluded, the one with Padua University for measuring removal sections as a function of neutron energy, and the other with Sorin for measuring neutron distribution in cylindrical penetrations. At Ispra measuring activities are under way for determining gamma ray propagation by means of concrete penetrations. Theoretical studies for interpreting such measurements are also in progress. The first results obtained so far are being presented here.

  3. Comparison of commercial diagnostic kits for placental lactogen radioimmunoassay

    International Nuclear Information System (INIS)

    Pirkl, S.; Kulenda, Z.

    1976-01-01

    The biochemical laboratory compared the following diagnostic kits for HPL determination: Pharmacia (Sweden), Radiochemical Center Amersham (GB), NEN (USA), Hoechst (FRG), applying the following criteria: 1. price, 2. number of analyses for which one kit may be applied, 3. expiration time, 4. speed, i.e., time elapsed from sample delivery to report (dependent on incubation time), 5. laboriousness, 6. reproducibility, 7. compatibility of values obtained by different kits. Alcohol precipitation (Pharmacia, RCC Amersham) appeared to be the most suitable while Dextran coated charcoal (NEN) and Amberlite (Hoechst) were somewhat more complicated, and the Sorin double antibody technique (ultrafiltration and washing of precipitate on filtres was used for separation) appeared to be the most laborious technique. RCC Amersham was ranked first owing to its lower cost as compared with runner-up Pharmacia. (L.O.)

  4. Aortic Valve Replacement With the Stentless Freedom SOLO Bioprosthesis: A Systematic Review.

    Science.gov (United States)

    Wollersheim, Laurens W; Li, Wilson W; Bouma, Berto J; Repossini, Alberto; van der Meulen, Jan; de Mol, Bas A

    2015-10-01

    This systematic review examined the clinical and hemodynamic performance of the stentless Freedom SOLO (Sorin Group, Milan, Italy) aortic bioprosthesis. The occurrence of postoperative thrombocytopenia was also analyzed. The Freedom SOLO is safe to use in everyday practice, with short cross-clamp times, and postoperative pacemaker implantation is notably lower. Valvular gradients are low and remain stable during short-term follow-up. Thrombocytopenia is more severe than in other aortic prostheses; however, this is without clinical consequences. Within a few years, the 15-year follow-up of this bioprosthesis will be known, which will be key to evaluating its long-term durability. Copyright © 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  5. Radioimmunoassay of glicagon secretion in diabetes mellitus

    International Nuclear Information System (INIS)

    Milanova, St.; Koparanova, O.; Milkov, V.; Visheva, N.; Kurtev, I.; Maleeva, A.

    1988-01-01

    Radioimunoassay of glucagon, lh, fsh, aldosterone, cortisol, acth, sth and lth was performed using preparations from the firms SORIN, AMERSHAM and HOECHST. The basal glucagon secretion was estimated in 403 diabetic patients and 84 normal subjects. It was transitorily suppressed by glucose. The alpha-cellular reactivity in diabetic patients was stimulated by insulin-induced hypoglycemia and with arginine and vasopressin. The tested group of diabetic patients had absolute hyperglucagonemia, despite the hyperglycemia, which is an evidence of abnormal alpha-cellular function. The insulin-dependent nature of hyperglucagonemia in diabetes mellitus and the hyperreactivity of glucagon secretion after protein stimulation was demonstrated. The correlation of these results leads to essential diagnostic inferences

  6. Elections to the Senior Staff Advisory Committee ("The Nine") 2009

    CERN Multimedia

    DG Unit

    2009-01-01

    Untitled Document The electronic voting process for the Senior Staff Advisory Committee ("The Nine") was closed on Friday, 5 June. Of the 433 Senior Staff members eligible to vote, 247 voted. The results are: Electoral Group 2 Name Department Votes Marco Cattaneo PH 62 Edmond Ciapala BE 57 Jean-Jacques Gras BE 33 Sorin Ilie TE 9 Erk Jensen BE 69 Jose Miguel Jimenez TE 67 Yacine Kadi EN 37 Paul Lecoq PH 39 Miguel Marquina IT 47 Hans Muller PH 33 James Purvis HR 113 Gerard Tranquille BE 16 Electoral Group 5 Name Department Votes Sudeshna Datta Cockerill HR 127 Jens Vigen GS 88 The elected persons are James Purvis (HR), Erk Jensen (BE), and Jose Miguel Jimenez (TE) for Electoral Gro...

  7. RIA of alpha-fetoprotein in serum and amniotic fluid

    Energy Technology Data Exchange (ETDEWEB)

    Fingerova, H; Talas, M; Stroufova, A [Palackeho Univ., Olomouc (Czechoslovakia). Lekarska Fakulta; Santavy, J; Krikal, Z [Ustav pro Peci o Matku a Dite, Prague (Czechoslovakia)

    1979-01-01

    An own modification of the double antibody radioimmunoassay for AFP using /sup 125/I-labelled AFP as a tracer, rabbit anti-AFP obtained from SEVAC, Prague and precipitating antibodies prepared by the authors is described. The AFP levels measured in the serum and the amniotic fluid using the method were in agreement with those obtained by the means of the AFPK RIA kit by SORIN in the Institute for the Care of Mother and Child in Prague. The AFP concentrations found in the cord serum and the amniotic fluid were confirmed also by the rocket electroimmunoassay according to Laurell. The described AFP RIA seems suitable for the clinical application in prenatal screening for congenital malformations, in difficult pregnancies, in hepatology and the diagnosis and the evaluation of therapy of some human malignancies.

  8. Overestimation of the 25(OH)D serum concentration with the automated IDS EIA kit.

    Science.gov (United States)

    Cavalier, Etienne; Huberty, Véronique; Cormier, Catherine; Souberbielle, Jean-Claude

    2011-02-01

    We have recently observed an increasing number of patients presenting very high serum levels of 25-hydroxyvitamin D [25(OH)D] (> 150 ng/mL), which, in all cases, had been measured with the IDS EIA kit adapted on different "open" automated platforms. We performed a comparison between the IDS EIA kit adapted on two different "open"automated platforms and the DiaSorin RIA. We found a systematic bias (higher levels with the IDS EIA kit) for concentrations more than 50-60 ng/mL that was less obvious when the IDS EIA was used in its manual procedure. We thus suggest to use the IDS EIA kit in its manual procedure rather than to adapt it on an automated platform, and to interpret cautiously a 25(OH)D greater than 100 ng/mL with this kit. Copyright © 2011 American Society for Bone and Mineral Research.

  9. In vitro evaluation of gaseous microemboli handling of cardiopulmonary bypass circuits with and without integrated arterial line filters.

    Science.gov (United States)

    Liu, Saifei; Newland, Richard F; Tully, Phillip J; Tuble, Sigrid C; Baker, Robert A

    2011-09-01

    The delivery of gaseous microemboli (GME) by the cardiopulmonary bypass circuit should be minimized whenever possible. Innovations in components, such as the integration of arterial line filter (ALF) and ALFs with reduced priming volumes, have provided clinicians with circuit design options. However, before adopting these components clinically, their GME handling ability should be assessed. This study aims to compare the GME handling ability of different oxygenator/ALF combinations with our currently utilized combination. Five commercially available oxygenator/ALF combinations were evaluated in vitro: Terumo Capiox SX25RX and Dideco D734 (SX/D734),Terumo Capiox RX25R and AF125 (RX/AF125), Terumo FX25R (FX), Sorin Synthesis with 102 microm reservoir filter (SYN102), and Sorin Synthesis with 40 microm reservoir filter (SYN40). GME handling was studied by introducing air into the venous return at 100 mL/min for 60 seconds under two flow/ pressure combinations: 3.5 L/min, 150 mmHg and 5 L/min, 200 mmHg. Emboli were measured at three positions in the circuit using the Emboli Detection and Classification (EDAC) Quantifier and analyzed with the General Linear Model. All circuits significantly reduced GME. The SX/D734 and SYN40 circuits were most efficient in GME removal whilst the SYN102 handled embolic load (count and volume) least efficiently (p circuits (p circuits (p circuits to handle GME. Venous reservoir design influenced the overall GME handling ability. GME removal was less efficient at higher flow and pressure, and for smaller sized emboli. The clinical significance of reducing GME requires further investigation.

  10. Assay-specific decision limits for two new automated parathyroid hormone and 25-hydroxyvitamin D assays.

    Science.gov (United States)

    Souberbielle, Jean-Claude; Fayol, Véronique; Sault, Corinne; Lawson-Body, Ethel; Kahan, André; Cormier, Catherine

    2005-02-01

    The recent development of nonradioactive automated assays for serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD) has made measurement of these two hormones possible in many laboratories. In this study, we compared two new assays for PTH and 25OHD adapted on an automated analyzer, the LIAISON, with two manual immunoassays used worldwide. We studied 228 osteoporotic patients, 927 healthy individuals, 38 patients with primary hyperparathyroidism, and 167 hemodialyzed patients. Serum PTH was measured with the Allegro and the LIAISON assays, and 25OHD was measured with DiaSorin RIA and the LIAISON assay. Regression analysis was used to calculate decision thresholds for the LIAISON assays that were equivalent to those of the Allegro PTH and DiaSorin 25OHD assays. The 25OHD concentrations obtained with the LIAISON assay and the RIA in osteoporotic patients were well correlated (r = 0.83; P 50 nmol/L as eligible for the reference population for the LIAISON PTH assay. In this group, the 3rd-97th percentile interval for LIAISON PTH was 3-51 ng/L. Considering upper reference limits of 46 and 51 ng/L for the Allegro and LIAISON assays, respectively, the frequency of above-normal PTH concentrations in patients with primary hyperparathyroidism was similar in both assays. Regression analysis between serum PTH measured by the Allegro and LIAISON assays in 167 hemodialyzed patients and the corresponding Bland-Altman analysis of these data suggest that the LIAISON PTH assay tends to read higher than the Allegro assay at low concentrations but lower at high concentrations (>300 ng/L). Because clinical decision limits for both PTH and 25OHD should be assay specific, we propose equivalences between these assays and two manual assays used worldwide. These assay-specific decision limits should help potential users of the LIAISON PTH and 25OHD assays.

  11. Establishment of reference values in a healthy population and interpretation of serum PTH concentrations in hemodialyzed patients according to the KDIGO Guidelines using the Lumipulse® G whole PTH (3rd generation) assay.

    Science.gov (United States)

    Cavalier, Etienne; Salsé, Margot; Dupuy, Anne-Marie; Bargnoux, Anne-Sophie; Watar, Florence; Souberbielle, Jean-Claude; Delanaye, Pierre; Cristol, Jean-Paul

    2018-04-01

    3rd generation PTH assays only detect the bioactive 1-84 fragment. Since standardization is still lacking, each new PTH assay requires to establish reference values and to assess the impact in the medical care of the mineral and bone disorders in hemodialyzed patients. Using Fujirebio Lumipulse G wPTH assay, serum PTH levels were measured in a population of 439 healthy subjects from France and Belgium PTH levels were also determined in 119 hemodialyzed patients. These patients were classified according to the KDIGO recommendation. Reference range was found to be 6.5 (90%CI: 6.0-7.0) - 41.8 (90% CI: 38.1-43.7). In hemodialysis patients, Passing-Bablock regression between 3rd generation PTH from Fujirebio and DiaSorin was DiaSorin = 1.01 xFujirebio-2.4 with a slope not different from 1.0(95%CI: 0.96-1.04) and a non-significant intercept, ranging from -6.0 to 0.1. Hemodialysis patients with a PTH concentration below 2-fold the Upper Limit of Normality (ULN), within the KDIGO range and upper 9-fold upper limit were respectively 33.6%, 54.6%, 11.8% (Fujirebio Lumipulse) and 36.1%, 51.3% and 12.6% (Diasorin Liaison). We determined a reference range with the 3rd generation PTH assay from Fujirebio. In a hemodialysis population, 3rd generation assays from Fujirebio and DiaSorin provide similar results. To the best of our knowledge, this is the first time that we can show similar PTH results obtained by 2 different 3rd generation PTH assays in healthy subjects and hemodialyzed patients without mathematically processing them. Copyright © 2018 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  12. EFEK PEMBERIAN KOMBINASI BUAH SIRIH (Piper betle L FRUIT, DAUN MIYANA (Plectranthus scutellarioides (L. R. BR. LEAF, MADU DAN KUNING TELUR TERHADAP PENINGKATAN AKTIVITAS DAN KAPASITAS FAGOSITOSIS SEL MAKROFAG

    Directory of Open Access Journals (Sweden)

    Yun Astuti Nugroho

    2012-11-01

    Full Text Available Latar belakang, kombinasi buah sirih (Piper betle L, daun miyana (Plectranthus scutellarioides (L. R. BR, madu dan kuning telur dimanfaatkan oleh masyarakat Sulawesi Utara untuk mengobati malaria.  Diharapkan kombinasi buah sirih (Piper betle L, daun miyana (Plectranthus scutellarioides (L. R. BR, madu dan kuning telur juga memiliki potensi untuk merangsang respon imun. Penelitian ini dilakukan untuk mengetahui pengaruh pemberian kombinasi buah sirih (Piper betle L, daun miyana (Plectranthus scutellarioides (L. R. BR, madu dan kuning telur terhadap aktivitas dan kapasitas sel makrofag. Metode, tiga puluh ekor mencit Swiss dibagi ke dalam 5 grup. Grup I mendapatkan air suling, grup II mendapatkan 0,55 mg/20g BB Stimuno. Sementara kelompok perlakuan: grup III sampai V masing-masing mendapatkan  0,07 mL; 0,21 mL; 0,6 mL/20 g BB. Bahan uji diberikan secara oral pada hari pertama sampai dengan ketujuh. Pada hari kedelapan, kepada masing-masing mencit disuntik secara intraperitoneal bakteri Staphylococcus aureus (SA. Aktivitas dan kapasitas sel  makrofag dihitung dari sediaan apus cairan peritoneum dengan menghitung persentase fagosit yang melakukan fagositosis dari 100 fagosit. Kapasitas fagositosis ditetapkan berdasarkan jumlah SA yang difagositosis oleh 50 fagosit aktif. Hasil, aktivitas dan kapasitas sel makrofag meningkat seiring dengan peningkatan dosis kombinasi buah sirih (Piper betle L, daun miyana (Plectranthus scutellarioides (L. R. BR, madu dan kuning telur dibandingkan dengan kontrol negatif. Kata  kunci: Buah sirih, Piper betle L, Makrofag, Fagositosis 

  13. The impact of excessive cutting on tree condition

    Directory of Open Access Journals (Sweden)

    Henryk Kociel

    2018-04-01

    Full Text Available The research was carried out to verify the impact of incorrect care practices on the value of trees. The research was carried out on a fragment of a lime-tree alley, located on a local road connecting Wólka Świątkowa and Krynka in the Lublin province. One side of the alley has been subjected to abnormal cuts, exceeding 50% of the volume of the crown, while the other remains intact. For this purpose, an analysis of the impact of the applied treatments on the condition of trees on the Rollof scale, analysis of life prognoses using the SULE method and the analysis of tree values and the assessment of tree loss as a result of cuts ensuing from the use of incorrect treatments were conducted. The analyses confirmed that the use of incorrect cuts contributed to the decline in the value of trees. The loss is so large that 1/3 of damaged trees have no chance for long and safe; moreover, these trees have lost 68% of their value.

  14. Mechanisms of Forest Restoration in Landslide Treatment Areas

    Directory of Open Access Journals (Sweden)

    Yi-Chang Chen

    2014-09-01

    Full Text Available Reforestation after a landslide facilitates competition between herbaceous plants and arborous plants. Tangible variations in grassland areas in regions susceptible to landslides can only be found within collections of trees. A landslide area in the Sule Watershed was investigated. Relative illuminance results reveal that the Rhodes grass (Chloris gayana Kunth biomass in this landslide area increases with relative illuminance. A comparison of regions with tree islands indicates that the size of the grassland areas decreased and the number of tree islands increased during 2005–2010. Furthermore, a germination experiment in a soil-seed bank indicates that more woody plant species exist around the tree island than in other areas in the landslide region. Trees in a tree island change the micro-climate of the landslide region, and they gather as many nutrients and as much moisture as possible, enabling vegetation to expand around the tree island. Additionally, the area with Rhodes grass and its biomass declined annually in the tree island region. Investigation results show that tree islands and soil-seed banks are suited to reforestation in landslide regions. The pioneering research will assist regional landslide management in Taiwan.

  15. A Review of Conflict of Interest, Competing Interest, and Bias for Toxicologists

    Science.gov (United States)

    One of the issues often associated with scientific misconduct is conflict of interest (CoI). Although there is a lack of uniformity in the definition of CoI, many express concerns that competing interests may bias research methods and the interpretation of data and conclusions. ...

  16. Why Increased Social Presence through Web Videoconferencing Does Not Automatically Lead to Improved Learning

    Science.gov (United States)

    Giesbers, Bas; Rienties, Bart; Tempelaar, Dirk T.; Gijselaers, Wim

    2014-01-01

    The Community of Inquiry (CoI) model provides a well-researched theoretical framework to understand how learners and teachers interact and learn together in computer-supported collaborative learning (CSCL). Most CoI research focuses on asynchronous learning. However, with the arrival of easy-to-use synchronous communication tools the relevance of…

  17. Type and Degree of Co-Occurrence of the Educational Communication in a Community of Inquiry

    Science.gov (United States)

    Gutiérrez-Santiuste, Elba; Gallego-Arrufat, María-Jesús

    2017-01-01

    The study analyzes the type and quantity of co-occurrence of social, cognitive, and teaching presence in a Community of Inquiry (CoI). Content analysis of the virtual educational communication shows units of analysis that must be assigned to more than one category. By crossing the categories of the CoI model, we observe that Social Presence is…

  18. Conflict of interest: A tenacious ethical dilemma in public health ...

    African Journals Online (AJOL)

    All involved in public policy processes are accountable for CoI, including experts, scientists, professionals, industry and government officials. The liquor industry in South Africa is presented as a case study. Generic principles of how to identify, manage and address CoI are discussed. We propose that health professionals ...

  19. Commercial conflict of interest and medical publication: What should the practising physician do about it?

    Science.gov (United States)

    Pais, Prem

    2016-01-01

    I read with interest the comment by Mark Wilson, which deals with possible conflict of interest (CoI) affecting publications in academic medical journals. This comment has specifically targeted the New England Journal of Medicine (NEJM) and its editor-in-chief Jeffrey Drazen on the "Vioxx scandal" which broke 15 years ago. Wilson's comment seems to be in response to a blog by Natarajan on CoI in medical publications. In the blog Natarajan writes of commercial CoI biasing publication of clinical trials and cites, among other examples, a publication in the NEJM on trials of voriconazole.

  20. Food for thought? Potential conflicts of interest in academic experts advising government and charities on dietary policies.

    Science.gov (United States)

    Newton, Alex; Lloyd-Williams, Ffion; Bromley, Helen; Capewell, Simon

    2016-08-05

    A conflict of interest (CoI) can occur between public duty and private interest, in which a public official's private-capacity interest could improperly influence the performance of their official duties and responsibilities. The most tangible and commonly considered CoI are financial. However, CoI can also arise due to other types of influence including interpersonal relationships, career progression, or ideology. CoI thus exist in academia, business, government and non-governmental organisations. However, public knowledge of CoI is currently limited due to a lack of information. The mechanisms of managing potential conflicts of interest also remain unclear due to a lack of guidelines. We therefore examined the independence of academic experts and how well potential CoI are identified and addressed in four government and non-governmental organisations in the UK responsible for the development of food policy. Policy analysis. We developed an analytical framework to explore CoI in high-level UK food policy advice, using four case studies. Two government policy-making bodies: Department of Health 'Obesity Review Group' (ORG), 'Scientific Advisory Committee on Nutrition' (SACN) and two charities: 'Action on Sugar' (AoS), & 'Heart of Mersey' (HoM). Information was obtained from publicly available sources and declarations. We developed a five point ordinal scale based upon the ideology of the Nolan Principles of Public Life. Group members were individually categorised on the ordinal ConScale from "0", (complete independence from the food and drink industry) to "4", (employed by the food and drink industry or a representative organisation). CoI involving various industries have long been evident in policy making, academia and clinical practice. Suggested approaches for managing CoI could be categorised as "deny", "describe", or "diminish". Declared CoI were common in the ORG and SACN. 4 out of 28 ORG members were direct industry employees. In SACN 11 out of 17 members

  1. Cardiac output determined by echocardiography in patients with cirrhosis: comparison with the indicator dilution technique

    DEFF Research Database (Denmark)

    Andersen, Ulrik B; Møller, Søren; Bendtsen, Flemming

    2003-01-01

    technique (CO(I)). METHODS: Twelve patients with cirrhosis were studied. CO(d) was measured as the spatial mean velocity of the left ventricular outflow tract, multiplied by the cross-sectional area and the heart rate. CO(I) was determined by the standard indicator dilution technique after injection of 125I...... albumin and 99mTc albumin into the right atrium and subsequent sampling from the femoral artery. RESULTS: The mean CO(d) and CO(I) were similar (7.20 vs 7.15 l/min, NS). A highly significant correlation was present between CO(d) and CO(I) (r = 0.86, P

  2. CORRESPONDENCE

    African Journals Online (AJOL)

    conflict of interest (CoI) is a growing problem in medical publi cations.[1] The critique ... For example, different sources cite academic commitments, personal relationships ... ecigarettes and the adoption of sugarsweetened beverage taxes, we.

  3. PENGARUH KONSENTRASI BAHAN STABILISATOR PEG 1000 DAN LAMA PERENDAMAN TERHADAP KESTABILAN DIMENSI KAYU KECAPI (Sandoricum koetjape Merr

    Directory of Open Access Journals (Sweden)

    Lusyiani Lusyiani

    2016-11-01

    Full Text Available Kayu bersifat higroskopis dan anisotropis, karena itulah untuk meningkatkan kualitas kayu diperlukan suatu perlakuan stabilisasi dimensi.  Tujuan dari penelitian ini adalah untuk menguji pengaruh konsentrasi Polyethylene Glycol 1000 dan waktu perendaman terhadap stabilisasi dimensi kayu yakni nilai penyusutannya.  Sampel yang digunakan dalam penelitian ini adalah Polyethylene glycol 1000, kayu Kecapi dan air suling sebagai pelarutnya.  Proses stabilisasi dimensi dilakukan dengan menggunakan metode proses difusi bulking yang mengganti bahan penstabilnya dengan air.  Sampel yang digunakan dalam penelitian ini adalah sebanyak 120 buah sampel.  Hasil penelitian menunjukkan bahwa Polyethylene Glycol 1000 pada tingkat konsentrasi 30% dan lama perendaman 5 hari memiliki nilai stabilisasi dimensi terbaik untuk semua parameter yang diuji.  Tingkat konsentrasi tertinggi untuk Polyethylene Glycol 1000 dan lama perendaman yang terlama, nilai penyusutannya paling kecil dan juga dapat meningkatkan nilai stabilisasi dimensi. Wood is hygroscopic and anisotropic, hence it is needed to improve the quality of wood by dimension stabilization treatment. The aim of study is to examine the effect of Polyethylene Glycol  1000 concentration and soaking time on the shrinkage rate stabilization dimensions. Polyethylene glycol 1000 and Kecapi wood were used in the research and distilled water as a solvent.  Stabilization was carried out by bulking method that replaced stabilizer material with water by diffusion process.  A member of 120 pieces samples were used in the study. The research results showed that Polyethylene Glycol  1000 at 30% concentration level and 5 days of soaking time have the best value of stabilization for all tested parameters.  The hingher level concentration of Polyethylene Glycol 1000 and the longer immersion time, smaller shrinkage and increasing the value of stabilization dimensions, as well.

  4. 微胶囊化阻燃剂对HDPE阻燃性能的影响%Effect of Microencapsulated Flame Retardant on Flame Retardancy of HDPE

    Institute of Scientific and Technical Information of China (English)

    陶圣熹; 夏艳平; 章诚; 曹峥; 陶国良

    2017-01-01

    以环氧树脂为囊材,阻燃剂二乙基次磷酸铝(ADP)和聚磷酸铵(APP)为芯材,制备了具有核壳结构的ADP微胶囊和APP微胶囊,并考察了其对高密度聚乙烯(HDPE)的阻燃性能.结果表明,当ADP微胶囊和APP微胶囊的总添加量为质量分数20%,复配质量比为2:1时,对HDPE的阻燃效果好,垂直燃烧达到V-0级,极限氧指数为32%,热失重残炭率为16.8%,拉伸强度达到21.6 M Pa.%Aluminum diethylphosphinate ( ADP ) microcapsules and ammonium polyphosphate (APP) microcapsules are prepared ,in which the epoxy resin is the shell , ADP and APP are the core .The effects of ADP and APP microcapsules on flame retarclancy of HDPE were studied . The results show that the total mass fraction of ADP microcap-sules and APP microcapsules is 20% with the ratio of 2 to 1 . The vertical burning is V-0 ,and the limit oxygen index is 32% . The carbon residue rate in the thermogravimetric (TG) test is 16 .8% . The maximum tensile strength is 21 .6 MPa ,and the material has the best flame retardant property .

  5. Pembuatan Arang Aktif dari Tempurung Kelapa dan Aplikasinya untuk Penjernihan Asap Cair

    Directory of Open Access Journals (Sweden)

    Siti Jamilatun

    2014-04-01

    Full Text Available Arang aktif merupakan senyawa karbon amorph, yang dapat dihasilkan dari bahan-bahan yang mengandung karbon atau dari arang yang diperlakukan dengan cara khusus untuk mendapatkan permukaan yang lebih luas. Arang aktif dapat mengadsorpsi gas dan senyawa-senyawa kimia tertentu atau sifat adsorpsinya selektif, tergantung pada besar atau volume pori-pori dan luas permukaan.. Arang aktif akan dibuat dari arang hasil pirolisis tempurung kelapa.dan diimplementasikan untuk menjernihkan asap cairnya. Adapun langkah yang pertama membuat arang aktif dari tempurung kelapa adalah, membuat arang tempurung kelapa dengan membersihkan tempurung kelapa terlebih dahulu dari bahan-bahan pengotor seperti tanah, kerikil. Kemudian mengeringkannya dibawah sinar matahari, selanjutnya membakar tempurung kering pada drum/bak pembakaran dengan suhu 300-500 0C selama 3-5 jam. Langkah yang kedua adalah arang hasil pembakaran direndam dengan bahan kimia CaCl2 dan ZnCl2 (kadar 25 % selama 12 sampai 24 jam untuk menjadi arang aktif. Selanjutnya melakukan pencucian dengan air suling/air bersih hingga kotoran atau bahan ikutan dapat dipisahkan. Arang aktif basah dihamparkan pada rak dengan suhu kamar untuk ditiriskan, kemudian dikeringkan dalam oven pada suhu 110 – 8000C selama 3 jam. Suhu aktivasi mempengaruhi kualitas karbon aktif yang terbentuk. Dari uji kualitas karbon aktif yang dilakukan, kualitas karbon aktif yang terbaik diperoleh pada suhu 800oC dengan kadar air 1,3 %, kadar abu 0,60 % memenuhi standar SII 0258-79 dan memiliki daya serap terhadap kadar iod sebesar 580,0 mg/g yang memenuhi standar SNI 06-3730. Penjernihan air limbah rumah tangga, air berwarna menggunakan karbon aktif dari suhu aktivasi 800oC menghasilkan air yang jernih, tidak berbau dan memenuhi pH standar air (7,0-7,5.

  6. Case series of feasibility considerations that impact operational delivery strategy in the highly competitive rheumatoid arthritis space in Asia

    Directory of Open Access Journals (Sweden)

    Wai K

    2013-02-01

    Full Text Available Karen Wai,1 Lisa Marie Saldanha,1 Elvira Zenaida Lansang,1 Saumya Nayak,1 Anish Sule,2 Ken J Lee31Feasibility and Site Identification Asia, Quintiles East Asia Pte Ltd, Singapore; 2Feasibility and Site Identification India, Quintiles India, Mumbai, India; 3Site Services Asia, Quintiles East Asia Pte Ltd, SingaporeAbstract: The rheumatoid arthritis (RA clinical trial space is very competitive, and recruiting and retaining subjects is of critical importance. Feasibility studies are a central component of ensuring successful recruitment and retention. A feasibility study is an assessment of the practicality of a proposed study protocol, with the goal of understanding challenges and providing risk mitigation strategies leading to better subject enrolment and study start-up should the assessment be favorable. This paper presents findings from a retrospective case series of RA feasibilities, describing important parameters to consider in the highly competitive RA space in Asia. Key parameters identified and discussed are how decisions on clinical development strategy necessitate changes in the clinical operational delivery strategy, with focus on changes in inclusion and exclusion criteria and patient contribution load; how small the patient population becomes when the clinical trial needs to target the patient population that is refractory to standard therapy; regulatory timelines; and the competitive clinical trial landscape. Feasibility assessments are a snapshot in time exercise. Multiple parameters change over time, and, particularly in a space that has become competitive for subjects, one cannot rely on one static feasibility assessment to predict trial performance accurately. Continuous feasibility assessment will also provide insight into the resourcing needs on the part of the sponsor, contract research organization, and investigative site.Keywords: site selection, country selection, clinical operations, risk management, recruitment rates

  7. Optimal algorithm switching for the estimation of systole period from cardiac microacceleration signals (SonR).

    Science.gov (United States)

    Giorgis, L; Frogerais, P; Amblard, A; Donal, E; Mabo, P; Senhadji, L; Hernández, A I

    2012-11-01

    Previous studies have shown that cardiac microacceleration signals, recorded either cutaneously, or embedded into the tip of an endocardial pacing lead, provide meaningful information to characterize the cardiac mechanical function. This information may be useful to personalize and optimize the cardiac resynchronization therapy, delivered by a biventricular pacemaker, for patients suffering from chronic heart failure (HF). This paper focuses on the improvement of a previously proposed method for the estimation of the systole period from a signal acquired with a cardiac microaccelerometer (SonR sensor, Sorin CRM SAS, France). We propose an optimal algorithm switching approach, to dynamically select the best configuration of the estimation method, as a function of different control variables, such as the signal-to-noise ratio or heart rate. This method was evaluated on a database containing recordings from 31 patients suffering from chronic HF and implanted with a biventricular pacemaker, for which various cardiac pacing configurations were tested. Ultrasound measurements of the systole period were used as a reference and the improved method was compared with the original estimator. A reduction of 11% on the absolute estimation error was obtained for the systole period with the proposed algorithm switching approach.

  8. Pivot design in bileaflet valves.

    Science.gov (United States)

    Vallana, F; Rinaldi, S; Galletti, P M; Nguyen, A; Piwnica, A

    1992-01-01

    The design criteria leading to the development of a new bileaflet valve (Sorin Bicarbon) were derived from the analysis of functional requirements, the performance of existing prostheses, and the availability of an advanced carbon coating technology (Carbofilm). The hinge is the critical element affecting fluid dynamics, durability, and thrombus formation in bileaflet valves. A comparative study of three existing models led to a new hinge design that was based on coupling two spheric surfaces with different radii of curvature (leaflet pivot and hinge recess) and obtained by electroerosion into a Carbofilm-coated metallic housing. In this valve, the point of contact moves continuously by rolling, not sliding. This minimizes friction and wear and allows uninterrupted washing of the blood exposed surfaces even during diastole (a finding established in patients using transesophageal echocardiography). Tricuspid implantation without anticoagulation in 33 sheep did not lead to thrombotic events (follow-up, 40-400 days). In the first 36 clinical implants observed for 15 months (mitral position, size 29; two unrelated deaths), the mean diastolic gradient by echo Doppler was 4 +/- 1.25 mmHg; the functional area was 3.2 +/- 0.6 cm2. No leaflet fracture and no thrombotic or embolic complications were observed clinically using a standard anticoagulant regimen.

  9. A numerical performance assessment of a commercial cardiopulmonary by-pass blood heat exchanger.

    Science.gov (United States)

    Consolo, Filippo; Fiore, Gianfranco B; Pelosi, Alessandra; Reggiani, Stefano; Redaelli, Alberto

    2015-06-01

    We developed a numerical model, based on multi-physics computational fluid dynamics (CFD) simulations, to assist the design process of a plastic hollow-fiber bundle blood heat exchanger (BHE) integrated within the INSPIRE(TM), a blood oxygenator (OXY) for cardiopulmonary by-pass procedures, recently released by Sorin Group Italia. In a comparative study, we analyzed five different geometrical design solutions of the BHE module. Quantitative geometrical-dependent parameters providing a comprehensive evaluation of both the hemo- and thermo-dynamics performance of the device were extracted to identify the best-performing prototypical solution. A convenient design configuration was identified, characterized by (i) a uniform blood flow pattern within the fiber bundle, preventing blood flow shunting and the onset of stagnation/recirculation areas and/or high velocity pathways, (ii) an enhanced blood heating efficiency, and (iii) a reduced blood pressure drop. The selected design configuration was then prototyped and tested to experimentally characterize the device performance. Experimental results confirmed numerical predictions, proving the effectiveness of CFD modeling as a reliable tool for in silico identification of suitable working conditions of blood handling medical devices. Notably, the numerical approach limited the need for extensive prototyping, thus reducing the corresponding machinery costs and time-to-market. Copyright © 2015 IPEM. Published by Elsevier Ltd. All rights reserved.

  10. Initial experience with the Freedom Solo® stentless aortic valve in a low volume centre.

    Science.gov (United States)

    Kolseth, Solveig Moss; Nordhaug, Dag; Stenseth, Roar; Wahba, Alexander

    2010-10-01

    Freedom Solo is a stentless biological aortic valve which is implanted supra-annularly with a single suture line. An increased risk of postoperative thrombocytopenia in the early postoperative period has been reported in recent studies. In our study we evaluated postoperative haemodynamic performance and thrombocyte-levels. Thirty seven patients who underwent valve implantation of the Sorin Freedom Solo stentless valve were included. The haemodynamic performance of the valve was evaluated by transthoracic echocardiography postoperatively at the fourth day (mean) and after a median of 4.2 months. The mean gradient (mmHg) of Freedom Solo was 7.5 at four days and 8.6 at 4.2 months. Postoperatively no patient had more than grade 1 leakage. Seven percent of the patients had a reduction of thrombocytes to less than 20% of the preoperative level. Seventy six percent had a minimum postoperative thrombocyte level less than 100*10(9)/L. The 30 days mortality in our patient material was zero. Implantation of the Freedom Solo valve was uncomplicated in our experience. Favourable transvalvular gradients and no significant leaks were found. In accordance with the literature, we found a high percentage of patients having a postoperative level of thrombocytes less than 100*10(9)/L after implantation of Freedom Solo.

  11. Mid-term haemodynamic and clinical results after aortic valve replacement using the Freedom Solo stentless bioprosthesis versus the Carpentier Edwards Perimount stented bioprosthesis.

    Science.gov (United States)

    van der Straaten, Ellen P J; Rademakers, Leonard M; van Straten, Albert H M; Houterman, Saskia; Tan, M Erwin S H; Soliman Hamad, Mohamed A

    2016-04-01

    The aim of this study was to investigate the mid-term haemodynamic and clinical results after aortic valve replacement (AVR) using the Sorin Freedom Solo (SFS) stentless bioprosthesis, compared with the standard Carpentier Edwards Perimount (CEP) stented bioprosthesis. In this retrospective cohort study of prospectively collected data, 116 patients were included in the SFS group (53 males; median age 74 years, range 56-85 years), and 122 patients in the CEP group (85 males; median age 73 years, range 43-88 years) between July 2007 and January 2013. Echocardiography was performed at 6 weeks after surgery in our centre, and the most recent echocardiography (in our centre or in referring cardiology departments) was requested. Between September 2013 and April 2014, all patients were called by the same researcher to gain clinical follow-up data. Mid-term mortality was 16.4% in the SFS group (19 patients) and 21.3% in the CEP group (26 patients); (P = 0.3). The mean transvalvular gradient was 7.4 ± 3.1 mmHg in the SFS group, and 11.6 ± 3.2 mmHg in the CEP group at 6 weeks postoperatively (P Solo stentless bioprosthesis is as safe as the Carpentier Edwards bioprosthesis, and provides better short- and mid-term haemodynamic performance than the Carpentier Edwards bioprosthesis. © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  12. Selective reversal of muscle relaxation in general anesthesia: focus on sugammadex

    Directory of Open Access Journals (Sweden)

    Sorin J Brull

    2009-04-01

    Full Text Available Sorin J Brull1, Mohamed Naguib21Department of Anesthesiology, Mayo Clinic College of Medicine, Mayo Clinic Hospital, Jacksonville, FL, USA; 2Department of Anesthesiology and Pain Medicine, The University of Texas M D Anderson Cancer Center,  Houston, TX, USAAbstract: Despite the significant improvements in the pharmacology of muscle relaxants in the past six decades, the search for the ideal muscle relaxant continues, mainly because of the incomplete efficacy and persistent side effects associated with their antagonism. Clinical concerns remain about the residual paralysis and hemodynamic side effects associated with the classic pharmacologic reversal agents, the acetylcholinesterase inhibitors. Although the development of the “ideal muscle relaxant” remains illusory, pharmacologic advancements hold promise for improved clinical care and patient safety. Recent clinical advances include the development of short-acting nondepolarizing muscle relaxant agents that have fast onset and a very rapid metabolism that allows reliable and complete recovery; and the development of selective, “designer” reversal agents that are specific for a single drug or class of drugs. This article reviews recent developments in the pharmacology of these selective reversal agents: plasma cholinesterases, cysteine, and sugammadex. Although each of the selective reversal agents is specific in its substrate, the clinical use of the combination of muscle relaxant with its specific reversal agent will allow much greater intraoperative titrating ability, decreased side effect profile, and may result in a decreased incidence of postoperative residual paralysis and improved patient safety.Keywords: selective reversal agents, cysteine, plasma cholinesterases, sugammadex

  13. Silvicultura „apropiată de natură” a revenit in Romania dupa 20 de ani. Întânirea anuală ProSilva – 28-30 iunie 2017, Sibiu, România [ProSilva Annual Meeting 28-30 June 2017, Sibiu, Romania

    Directory of Open Access Journals (Sweden)

    Borlea G.F.

    2017-07-01

    Full Text Available After 20 years, Pro Silva Europe met for the 28th annual meeting in Romania (28-30 June 2017, Sibiu. The meeting was attended by 45 participants from 17 European countries which have met in Sibiu and spent together with Romanian foresters three days in the Romanian forests. In the first day were visited the forests from Avrig Forest District to observe the application of traditional forestry practices being accompanied by Robert Blaj, the manager of the Forestry Directorate from Sibiu. In the second day, together with Mr. Dr. Guiman Gheorghe and other researchers, were visited the forests of the „Marin Dracea” National Institute from the Regional Research Institute Mihaesti, Arges County, where was presented the unevenaged management in beech forest and in the mixed forests of oak and beech. On the last day, along with practitioners, teachers, scholars from the Faculty of Silviculture and Forest Engineering, Transilvania University of Brasov, the host Urda Sorin, the manager of the ”Pădurile Șincii” Forest District, presented to all atendees the 350-hectare natural reserve, recently included on the UNESCO list, along with other virgin forests in Romania. The president of Pro Silva Europa, Eckart Senitza, were impressed by the profesionalism of romanian foresters, researchers and professors which are into ProSilva values and he hopes, along with the experience of European ProSilva members, to extend to a broad scale the principles of ProSilva in Romania for a better forestry in the future

  14. 19 mm sized bileaflet valve prostheses' flow field investigated by bidimensional laser Doppler anemometry (part I: velocity profiles).

    Science.gov (United States)

    Barbaro, V; Grigioni, M; Daniele, C; D'Avenio, G; Boccanera, G

    1997-11-01

    The investigation of the flow field downstream of a cardiac valve prosthesis is a well established task. In particular turbulence generation is of interest if damage to blood constituents is to be assessed. Several prosthetic valve flow studies are available in literature but they generally concern large-sized prostheses. The FDA draft guidance requires the study of the maximum Reynolds number conditions for a cardiac valve model to assess the worst case in turbulence by choosing both the minimum valve diameter and a high cardiac output value as protocol set up. Within the framework of a national research project regarding the characterization of cardiovascular endoprostheses, the Laboratory of Biomedical Engineering is currently conducting an in-depth study of turbulence generated downstream of bileaflet cardiac valves. Four models of 19 mm sized bileaflet valve prostheses, namely St Jude Medical HP Edwards Tekna, Sorin Bicarbon, and CarboMedics, were studied in aortic position. The prostheses were selected for the nominal annulus diameter reported by the manufacturers without any assessment of the valve sizing method. The hemodynamic function was investigated using a bidimensional LDA system. Results concern velocity profiles during the peak flow systolic phase, at high cardiac output regime, highlighting the different flow field features downstream of the four small-sized cardiac valves.

  15. Velocity and shear stress distribution downstream of mechanical heart valves in pulsatile flow.

    Science.gov (United States)

    Giersiepen, M; Krause, U; Knott, E; Reul, H; Rau, G

    1989-04-01

    Ten mechanical valves (TAD 27 mm): Starr-Edwards Silastic Ball, Björk-Shiley Standard, Björk-Shiley Concave-Convex, Björk-Shiley Monostrut, Hall-Kaster (Medtronic-Hall), OmniCarbon, Bicer Val, Sorin, Saint-Jude Medical and Hemex (Duromedics) are investigated in a comparative in vitro study. The velocity and turbulent shear stress profiles of the valves were determined by Laser Doppler anemometry in two different downstream axes within a model aortic root. Depending on the individual valve design, velocity peaks up to 1.5 m/s and turbulent shear stress peaks up to 150 N/m2 were measured during the systolic phase. These shear stress peaks mainly occurred in areas of flow separation and intense momentum exchange. Directly downstream of the valves (measuring axis 0.55.dAorta) turbulent shear stress peaks occurred at peak systole and during the deceleration phase, while in the second measuring axis (1.5.dAorta) turbulence levels were lower. Shear stress levels were high at the borders of the fluid jets. The results are discussed from a fluid-dynamic point of view.

  16. Low serum vitamin D concentrations in patients with schizophrenia.

    Science.gov (United States)

    Itzhaky, Dganit; Amital, Daniela; Gorden, Katya; Bogomolni, Alisa; Arnson, Yoav; Amital, Howard

    2012-02-01

    Vitamin D is increasingly associated with the pathology of cognition and mental illness. Vitamin D receptors have been detected on neurons that regulate behavior. To assess vitamin D serum concentrations in patients with major depression and schizophrenia as compared to healthy controls and to determine if a correlation exists between serum levels of vitamin D and disease activity. We recruited 50 patients with schizophrenia and compared them to 33 patients with major depression and 50 controls with no major psychopathology. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia and the Hamilton Depression scale for depression were administered on the same day the blood samples were drawn. We used LIAISON 25-OH vitamin D (DiaSorin) immunoassay to measure serum concentrations of 25-OH vitamin D. Lower serum vitamin D concentrations were detected among patients with schizophrenia (15.0 +/- 7.3 ng/ml) compared to patients with depression (19.6 +/- 8.3 ng/ml) and to controls (20.2 +/- 7.8 ng/ml, P vitamin D levels. Serum vitamin D levels were lower in patients with schizophrenia as compared to patients with depression and to healthy controls. No correlation was found between serum concentration and disease activity. Additional studies are needed to elucidate the role of vitamin D in the autoimmune mechanism and in the pathogenesis of schizophrenia.

  17. Assay of anti-HBs antibodies using a recombinant antigen and latex particle counting: comparison with five commercial tests.

    Science.gov (United States)

    Galanti, L M; Cornu, C; Masson, P L; Robert, A R; Becheanu, D; Lamy, M E; Cambiaso, C L

    1991-05-01

    An assay of anti-HBs antibodies based on agglutination of latex particles coated with recombinant HBs-antigen was compared with Abbott radioimmunoassay (Abbott-RIA), which uses a human plasma-derived antigen. The population examined consisted of 76 Abbott-RIA anti-HBs-negative prevaccinated subjects and 1044 serum samples anti-HBs found positive by Abbott-RIA, including 283 samples of subjects vaccinated either with a human plasma-derived vaccine (group A; n = 180) or with a recombinant vaccine (group B; n = 103). Correlation coefficients between the two techniques were respectively r = 0.89 for the whole population (n = 1044), r = 0.98 in group A and r = 0.74 in group B. Anti-HBs titres were higher with latex than with RIA in group B as shown by the regression slopes: latex = 508 + 1.11 RIA in group A and latex = -1138 + 3.97 RIA in group B, suggesting that some vaccinated subjects from group B produced antibodies against epitopes proper to the recombinant antigen. In the prevaccinated population and in group A, the latex results were compared with those of radioimmunoassays (Abbott, Sorin) and enzyme immunoassays (Behring, Roche, Pasteur). Only the Roche-EIA detected anti-HBs in the prevaccinated subjects. The correlation between the various immunoassays was r greater than 0.96 only for values higher than 100 IU/l.

  18. History of the pharmacies in the town of Aleşd, Bihor county.

    Science.gov (United States)

    Paşca, Manuela Bianca; Gîtea, Daniela; Moisa, Corina

    2013-01-01

    In 1848 pharmacist Horváth Mihály established the first pharmacy in Aleşd, called Speranţa (Remény). Following the brief history of this pharmacy we will notice that in 1874 the pharmacy comes into the possession of Kocsiss József. In 1906 the personal rights of the pharmacy are transcribed to Kocsiss Béla, and since 1938 the his son, Kocsiss Dezső, pharmacist, became the new owner. In 1949 the pharmacy was nationalized and became the property of the Pharmaceutical Office Oradea, the pharmacy got the name Farmacia nr. 22 of Aleşd, and continued its activity throughout the whole communist period. Starting with the year 1991 it entered into private system as Angefarm, as the property of Mermeze Gheorghe, pharmacist, and from 2003 until now works under the name Vitalogy 3, as the property of Ghitea Sorin. A second pharmacy, Sfântul Anton was founded in 1937 by pharmacist Herceg Dobreanu Atena, which however had no continuity during the communist period.

  19. Radioimmunoscintigraphy in lung cancer diagnosing

    International Nuclear Information System (INIS)

    Hadjikostova, H.

    1999-01-01

    As the lung cancer is the leading cause of death from cancer at males, the exact staging is essential. Monoclonal antibodies marked with radionuclides like 131 I, 111 In, 99m Tc, etc., allow detecting and staging the small cell lung cancer with sensibility 90%, specificity 45% and accuracy 85%. It is suggested this method to be applied simultaneously with computerized tomography. The diagnostic possibility of radioimmunoscintigraphy (RIS) in earlier detection, recurrence or metastasis as well as follow up the effect of therapy performed at patients with lung cancer are reviewed. RIS is performed with IODOMAB-R-2 (Sorin Biomedica) 131 I antiCEA Mob F(ab') 2 , dose 92.5-185 MBq. Planar images were performed 72 hours after i.v. injection. Four patients with epidermoid squamous cell cancer were examined. Positive results were obtained at 3 patients and one false negative. In general sensitivity of radioimmunoscintigraphy of lung cancer is 75-90%. However there are difficulties at its application linked with necessity of permanent availability of radiolabelled antibodies with high specific activity at the moment of their injection. Despite all radioimmunoscintigraphy is developing as an useful diagnostic method for evaluation and follow up of lung cancer patients

  20. Nicolae Milescu Spătarul - ancestor of a Nobel Laureate - Ilia I. Mecinikov. Part I. Nicolae Milescu-Spătarul’s secular European impact; 1st of June 2011 - 375 years since the birth of the European erudite

    Directory of Open Access Journals (Sweden)

    Dan RIGA

    2011-01-01

    Full Text Available The culture of tradition and patrimony is an act of civilization, as well as one of identitaryeducation. This is why the promotion of restitution comprises all areas of progress and humancreation.Nicolae Milescu-Spătarul (b. 1636 in Moldavia - d. 1708 in Russia was an eruditehumanist scholar, an encyclopaedist, a theologist, diplomat, historian, geographer, ethnographer,translator, memorialist and a polyglot (Romanian, ancient and modern Greek, Latin, Turkish andSlavonic-Russian. Commemorating and honouring this figure, of European and Eurasianimportance alike, is a debt of honour: 1958 – 250 years since death; 2011 – 375 years since birth.At this time, the need to fully publish his work arises, as a large part of it is still kept in libraries,archives and European private collections in the form of manuscripts. Nicolae Milescu-Spătarulwas the ancestor of the Nobel Laureate (1908, scientist Ilia I. Mecinikov (1845-1916.The work reveals the great scholar’s (eastern, but also western, European and Asiancultural, scientific and diplomatic impact – at that moment and throughout time – but also theSorin Riga, Dan Riga, Vasile Man - Nicolae Milescu Spătarul - ancestor of a Nobel Laureate - Ilia I. Mecinikov impact of his vast work. The remarkable monograph The Description of China (58 chapters was published in Romanian only in 1958.

  1. Radioimmunoscintigraphy with 99mTc-labelled anti-CEA monoclonal antibodies in colorectal carcinoma patients

    International Nuclear Information System (INIS)

    Sergieva, S.; Baychev, G.; Tzingilev, D.; Delijski, T.; Kirova, G.; Kirilova, B.; Nenovska, M.

    1998-01-01

    Sixteen patients (2 female and 14 male, aged 42-75) were given intravenous injections with 99m Tc (555-740 MBq)-labelled anti-CEA MAb (CEA-Scan, Mallinckrodt Medical and M-CEATEC, Sorin Biomedica). Five of them were with duly established or established or suspected primary colorectal carcinoma, and eleven were studied postoperatively after recording an increase CEA levels in serum. The patients were scanned within 4-24 h of infusion using planar and tomographic imaging in rotation gamma-camera DIACAM (Siemens). At all 16 patients 27 true positive results were obtained: in 7 primary colorectal carcinomas, 5 locally recurrent tumors, 7 liver metastases, 6 lymphogeneous lesions and two - in the ureteral region. True negative results were established at three patients, false positive - in one patient with chronic inflammation, and false negative results - in 3 cases with liver metastases foci < 8 mm. Having 90 % sensitivity, 75 % specificity and 82.3 % accuracy, radioimmunoscintigraphy is a highly informative and sensitive imaging method for diagnosing and following up of primary, recurrent and metastatic foci in colorectal carcinoma patients. (author)

  2. Immunoscintigraphy of gastrointestinal tract carcinomas

    International Nuclear Information System (INIS)

    Mladenov, B.; Peshev, N.

    1995-01-01

    The results of labelled monoclonal antibodies (MoA) immunoscintigraphy in malignant tumors involving the gastrointestinal tract are presented. The obtained data have an essential practical bearing on the early diagnosis and radical treatment undertaken. Immunoscintigraphy is performed with Imacis-I ( 131 I, monoclonal antibody, 19-9 F(ab') 2 anti-CEA F(ab') 2 ) obtained from the CIS company, and Jodomab-R-2( 131 I, anti-CEA monoclonal antibody F(ab') 2 ) of the Sorin Biomedica Company, inserted at activity ranging from 11 to 185 MBq. Scanning by a planar gamma-camera is performed at 72 hours. A total of twenty-four patients are examined: 14 preoperatively (with gastric cancer - 2, pancreatic cancer - 1 and location of the neoplasm in different segments of the colon - 11), and ten postoperatively. Positive results are obtained in twenty-two (92 per cent) of the total number of patients under study. In twelve (86 per cent) of those examined preoperatively intensive accumulation of labelled autoantibodies in the cancer area is documented with a negative result recorded in two cases only. Metastases are found in two patients operated on, while in the remainder the results are negative and consistent with those of the other methods of examination. 13 refs., 4 figs. (author)

  3. Serum gastrin: interests and limitations of radio-immunoassay

    International Nuclear Information System (INIS)

    Rougier, P.; Linhart, N.; Bok, B.

    1980-01-01

    Radio-immunoassay of serum gastrin may now be carried out in all laboratories of radio-immunology. Comparison of two commercial kits A: Schwartz-Mann and B: CEA-SORIN according to criteria of specificity, sensitivity and reproducibility within and between systems, shows that they both permit the detection of pathological hypergastrinemias (Zollinger Ellison and atropic gastritis). Both kits have an identical intrasystem coefficient of variation (10 p. cent and 7 p. cent fort A, 5 p. cent and 8 p. cent for B) on the other hand, the inter-system coefficient of variation is better for kit B (22.4 p. cent and 37 p. cent for kit A, and 11.5 p. cent and 14.2 p. cent for kit B). The normal values for each kit are quite different: 97 . 64 pg.ml -1 for A and 51 . 23 pg.ml -1 for B preventing one from comparing estimations carried out with two different kits [fr

  4. Déchets nucléaires : où est le problème ?

    CERN Document Server

    Sorin, Francis

    2015-01-01

    Faut-il avoir peur des déchets nucléaires ? Sont-ils vraiment, comme le pense une partie du public, ce fardeau empoisonné ingérable faisant peser une menace fatale sur nous-mêmes et sur nos descendants ? Ou sont-ils au contraire, comme l'estime la grande majorité des scientifiques, des résidus que l'on sait fort bien conditionner et mettre hors d'état de nuire ? Entre le public inquiet et les ingénieurs rassurants, comment comprendre l'immense décalage des attitudes ? Et comment, face à ces déchets laissés en héritage, faire la part des choses entre ceux qui dénoncent "un crime contre les générations futures" et ceux qui jugent "la difficulté résolue" ? Bref, "Où est le problème ?" Sans craindre de bousculer bien des idées reçues mais sans méconnaître les risques encourus, Francis Sorin éclaire ici en quelques chapitres percutants les problèmes et les solutions liés à la gestion de ces déchets en France. II s'attache particulièrement au devenir des déchets de haute activité et...

  5. Flow visualization of a monoleaflet and bileaflet mechanical heart valve in a pneumatic ventricular assist device using a PIV system.

    Science.gov (United States)

    Lee, Hwansung; Tatsumi, Eisuke; Taenaka, Yoshiyuki

    2010-01-01

    Our group is developing a new type of pulsatile pneumatic ventricular assist device (PVAD) that uses the Medtronic Hall tilting disc valve (M-H valve). Although tilting disc valves have good washout effect inside the blood pump, they are no longer in common clinical use and may be difficult to obtain in the future. To investigate the stability of the Sorin Bicarbon valve (S-B valve) in our PVAD, we constructed a model pump made of an acrylic resin with the same configuration as our PVAD and attempted to compare the flow visualization upstream and downstream of the outlet position valve between the M-H valve and the S-B valve using a particle image velocimetry (PIV) method. The outlet S-B valve had faster closure than the M-H valve. The maximum flow velocity was greater than with the M-H valve. The maximum Reynolds shear stress (RSS) of the M-H valve reached 150 N/m(2) and that of the S-B valve reached 300 N/m(2) upstream during the end-systolic and early-diastolic phases. In both valves, the maximum RSS upstream of the valve was higher than downstream of the valve because of the regurgitation flow during valve closure. In addition, the maximum viscous shear stress reached above 2 N/m(2), which occupied only about 1%-1.5% of the maximum RSS.

  6. Food for thought? Potential conflicts of interest in academic experts advising government and charities on dietary policies

    Directory of Open Access Journals (Sweden)

    Alex Newton

    2016-08-01

    Full Text Available Abstract Background A conflict of interest (CoI can occur between public duty and private interest, in which a public official’s private-capacity interest could improperly influence the performance of their official duties and responsibilities. The most tangible and commonly considered CoI are financial. However, CoI can also arise due to other types of influence including interpersonal relationships, career progression, or ideology. CoI thus exist in academia, business, government and non-governmental organisations. However, public knowledge of CoI is currently limited due to a lack of information. The mechanisms of managing potential conflicts of interest also remain unclear due to a lack of guidelines. We therefore examined the independence of academic experts and how well potential CoI are identified and addressed in four government and non-governmental organisations in the UK responsible for the development of food policy. Methods Policy analysis. We developed an analytical framework to explore CoI in high-level UK food policy advice, using four case studies. Two government policy-making bodies: Department of Health ‘Obesity Review Group’ (ORG, ‘Scientific Advisory Committee on Nutrition’ (SACN and two charities: ‘Action on Sugar’ (AoS, & ‘Heart of Mersey’ (HoM. Information was obtained from publicly available sources and declarations. We developed a five point ordinal scale based upon the ideology of the Nolan Principles of Public Life. Group members were individually categorised on the ordinal ConScale from “0”, (complete independence from the food and drink industry to “4”, (employed by the food and drink industry or a representative organisation. Results CoI involving various industries have long been evident in policy making, academia and clinical practice. Suggested approaches for managing CoI could be categorised as “deny”, “describe”, or “diminish”. Declared CoI were common in the ORG and SACN

  7. Contamination of the Th II line and the age of the Galaxy

    International Nuclear Information System (INIS)

    Lawler, J.E.; Whaling, W.; Grevesse, N.

    1990-01-01

    The age of the Galaxy may be estimated from observations of the ratio of stellar abundances of thorium, which has only one long-lived isotope with a half-life comparable to the suspected age of the Galaxy, and neodymium, a stable element. The Th/Nd abundance ratio in a sample of G-dwarf stars of different ages was derived from the intensities of one Th II and one Nd II absorption line, and indicated a rather young galactic age of 9.6 Gyr. But the Th II line is blended with a Co I line. Here we determine the transition probability of the Co I line by combining radiative lifetime and branching-ratio measurements. We show that the Co I contribution cannot be neglected in deriving Th/Nd ratios. By comparing our results with predictions based on models of galactic chemical evolution, we suggest a revised age of the Galaxy of 15-20 Gyr. (author)

  8. Non-invasive measurement of cardiac output by Finometer in patients with cirrhosis

    DEFF Research Database (Denmark)

    Kaltoft, N; Hobolth, L; Møller, S

    2010-01-01

    .6 [3.9;9.7] l min(-1) (mean +/- SD [range]) compared to mean CO(F) of 7.2 +/- 2.3 [3.1;11.9] l min(-1). There was a mean difference between CO(F) and CO(I) of 1.0 +/- 1.8 [-2.1;4.0] l min(-1) and 95% confidence interval of [0.2;1.8], P...-blockade, mean DeltaCO(I) was 1.6 +/- 1.4 [-0.1;3.3] l min(-1) compared to mean DeltaCO(F) of 1.9 +/- 1.3 [0.4;3.8] l min(-1). Mean difference between DeltaCO(F) and DeltaCO(I) was 0.3 +/- 0.3 [-0.2;0.7] l min(-1) with a 95% confidence interval of [-0.1;0.6], P = 0.11. Compared with invasive measurements...

  9. Implementing collaborative improvement - top-down, bottom-up or both?

    DEFF Research Database (Denmark)

    Kaltoft, Rasmus; Boer, Harry; Caniato, Federico

    2007-01-01

    , the study identifies three different implementation approaches. The bottom-up learning-by-doing approach starts at a practical level, with simple improvement activities, and aims at gradually developing a wide range of CoI knowledge, skills and initiatives. The top-down directive approach starts...... with aligning the partners' CoI objectives and an assessment of their collaboration and CoI maturity in order to provide a common platform before actually starting improvement activities. The laissez-faire approach builds on shared goals/vision, meetings on equal terms and joint work, in a non-directive and non......-facilitated way, though. The article demonstrates how and why the different approaches have different effects on the development of collaborative improvement....

  10. Ligand and Metal Based Multielectron Redox Chemistry of Cobalt Supported by Tetradentate Schiff Bases.

    Science.gov (United States)

    Andrez, Julie; Guidal, Valentin; Scopelliti, Rosario; Pécaut, Jacques; Gambarelli, Serge; Mazzanti, Marinella

    2017-06-28

    We have investigated the influence of bound cations on the reduction of cobalt complexes of redox active ligands and explored the reactivity of reduced species with CO 2 . The one electron reduction of [Co II ( R salophen)] with alkali metals (M = Li, Na, K) leads to either ligand-centered or metal-centered reduction depending on the alkali ion. It affords either the [Co I ( R salophen)K] complexes or the [Co II 2 (bis-salophen)M 2 ] (M = Li, Na) dimers that are present in solution in equilibrium with the respective [Co I (salophen)M] complexes. The two electron reduction of [Co II ( OMe salophen)] results in both ligand centered and metal centered reduction affording the Co(I)-Co(II)-Co(I) [Co 3 (tris- OMe salophen)Na 6 (THF) 6 ], 6 complex supported by a bridging deca-anionic tris- OMe salophen 10- ligand where three OMe salophen units are connected by two C-C bonds. Removal of the Na ion from 6 leads to a redistribution of the electrons affording the complex [(Co( OMe salophen)) 2 Na][Na(cryptand)] 3 , 7. The EPR spectrum of 7 suggests the presence of a Co(I) bound to a radical anionic ligand. Dissolution of 7 in pyridine leads to the isolation of [Co I 2 (bis- OMe salophen)Na 2 Py 4 ][Na(cryptand)] 2 , 8. Complex 6 reacts with ambient CO 2 leading to multiple CO 2 reduction products. The product of CO 2 addition to the OMe salophen ligand, [Co( OMe salophen-CO 2 )Na] 2 [Na(cryptand)] 2 , 9, was isolated but CO 3 2- formation in 53% yield was also detected. Thus, the electrons stored in the reversible C-C bonds may be used for the transformation of carbon dioxide.

  11. City Life in the Midst of the Forest: a Punan Hunter-Gatherer's Vision of Conservation and Development

    Directory of Open Access Journals (Sweden)

    Patrice Levang

    2007-06-01

    Full Text Available The Punan Tubu, a group of hunter-gatherers in East-Kalimantan, Indonesia, are used to illustrate the very real trade-offs that are made between conservation and development. This group has undergone various forms of resettlement in the 20th century, to the point that some are now settled close to the city of Malinau whereas others remain in remote locations in the upper Tubu catchment. This study is based on several years of ethnographic and household analysis. The Punan clearly favor both conservation and development. In the city, the Punan benefit from all positive effects of development. Child and infant mortality rates are very low, and illiteracy has been eradicated among the younger generation. However, the Punan complain that nothing in town is free. The older generation, in particular, resents the loss of Punan culture. Because of frustration and unemployment, young people often succumb to alcoholism and drug addiction. The Punan do not want to choose between conservation and development, between forest life and city life. They want to benefit from the advantages of both locations, to enjoy both free forest products and the positive aspects of modern life, to go wild boar hunting in the morning and watch television in the evening. In short, they want to enjoy city life in the midst of the forest. The same kind of contradiction has led to identity problems. They want to uphold the traditional life of the hunter-gatherer, but at the same time they reject marginalization and seek integration into the larger society. In short, they want integration without loss of identity. The settlement of Sule-Pipa illustrates how some groups have dealt with the contradiction more successfully. Thanks to good organization and charitable donations, they have secured educational facilities and basic health care, and marketing costs are reduced by collectively organized road and river transportation. The economy of the village is thriving, mainly because of

  12. Identifikasi dan Pengendalian Jamur Busuk Putih Buah Salak dengan Ekstrak Bunga Kecombrang (Nicolaia speciosa

    Directory of Open Access Journals (Sweden)

    Aries Pratomo

    2009-12-01

    dari isolat. Bunga kecombrang diekstrak dengan cara Soxhlet dalam alkohol. Alkohol diuapkan dengan rotavapor dan ekstrak kasar dilarutkan dalam air suling. Pengujian pengaruh ekstrak bunga kecombrang dilakukan secara in vitro dan penyemprotan pada buah yang sudah dipetik dan buah pada tandan. Hasil penelitian menunjukkan bahwa patogen busuk putih buah salak adalah Chalaropsis sp. Buah salak lepas tandan lebih rentan terhadap infeksi Chalaropsis dari pada yang masih menempel. Berdasarkan pengujian in vitro, ekstrak bunga kecombrang pada konsentrasi 48–50% dapat menghambat pertumbuhan koloni Chalaropsis sp. hingga 90 %. Penyemprotan ekstrak bunga kecombrang mampu menghambat pertumbuhan Chalaropsis sp. pada buah salak lepas tandan atau yang menempel tandan. Ekstrak pekat dapat 100% melindungi buah salak dari infeksi oleh Chalaropsis sp.

  13. 相分离法制备多孔聚甲基丙烯酸甲酯(PMMA)微胶囊%Synthesis of porous poly(methylmethacrylate) microcapsules by internal phase separation

    Institute of Scientific and Technical Information of China (English)

    王建平; 李丹; 康召青; 高阳; 李伟; 王学晨; 张兴祥

    2016-01-01

    N-isopropylacrylamide polymer (PNIPAm) as thermosensitive pore-foaming agent was introduced into the system for the synthesis of porous core-shell microcapsules by internal phase separation. The system is composed of n-octadecane (n-Oct), methylmethacrylate (MMA) and sodium salt of styrene-maleic anhydride copolymer (SMA) aqueous solution forming a micro emulsion. The effect of PNIPAm on the formation mechanism, surface morpholo-gies, and thermal stabilities of the MicroPCMs was studied by using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and thermogravimetric analysis (TG), respectively. The results indicate that adding PNIPAm into the system, the resulting microcap-sules have some irregular holes on the capsule shell. The size of the microcapsules is in the range of 2.0-4.0μm. The number of holes increases with the addition of PNIPAm, when the addition amount of 0.3-1.2 g. At the same time, the number of the holes decreases with the increase of the molecular weight of PNIPAm and the content of MMA, so only the PNIPAm with small molecular weight conducive to the synthesis of porous microcapsules.%以具有温敏性的线性聚N-异丙基丙烯酰胺(PNIPAm)为致孔剂,在十八烷(n-Oct)/甲基丙烯酸甲酯(MMA)/苯乙烯马来酸酐共聚物钠盐(SMA)水溶液微乳液体系中用相分离法制得包覆有n-Oct的多孔聚甲基丙烯酸甲酯(PMMA)微胶囊,采用扫描电子显微镜(SEM)、差示扫描量热仪(DSC)、热重分析仪(TG)等手段分别考察了这种多孔PMMA微胶囊.实验结果表明:所得多孔微胶囊粒径在2.0~4.0μm,呈多孔微球状,当PNIPAm的添加质量为0.3~1.2 g时,多孔PMMA微胶囊表面孔隙数量稍有增加,而当增加MMA的用量或者增加PNIPAm相对分子质量时,多孔PMMA微胶囊表面孔隙数量下降.

  14. Examination of the effect of ovarian radiation injury induced by hysterosalpingography on ovarian proliferating cell nuclear antigen and the radioprotective effect of amifostine: an experimental study

    Directory of Open Access Journals (Sweden)

    Can B

    2018-05-01

    Full Text Available Behzat Can,1 Remzi Atilgan,1 Sehmus Pala,1 Tuncay Kuloğlu,2 Sule Kiray,3 Nevin Ilhan4 1Department of Obstetrics and Gynecology, Firat University School of Medicine, Elazig, Turkey; 2Department of Histology and Embryology, Firat University School of Medicine, Elazig, Turkey; 3Department of Obstetrics and Gynecology, Maltepe University School of Medicine, Istanbul, Turkey; 4Department of Biochemistry, Firat University School of Medicine, Elazig, Turkey Aim: The aim of this study was to examine the effect of amifostine on cellular injury in the ovarian tissue induced by hysterosalpingography (HSG.Methods: In total, forty 4-month old female Wistar Albino rats were assigned into 8 groups. Each group contained 5 rats. Group 1 (G1: rats were decapitated without any procedure. Group 2 (G2: rats were decapitated after 3 hours of total body irradiation. Group 3 (G3: rats were decapitated 3 hours after HSG procedure. Group 4 (G4: rats were decapitated 3 hours after HSG procedure performed 30 min after receiving amifostine 200 mg/kg intraperitoneally. Group 5 (G5: rats were decapitated after 1 month without any procedure. Group 6 (G6: rats were decapitated after 1 month of total body irradiation. Group 7 (G7: rats were decapitated 1 month after HSG procedure. Group 8 (G8: rats were decapitated 1 month after HSG procedure performed 30 min after receiving amifostine 200 mg/kg intraperitoneally. After rats were decapitated under general anesthesia in all groups, blood samples were obtained and bilateral ovaries were removed. One of the ovaries was placed in 10% formaldehyde solution for histological germinal epithelial degeneration, apoptosis and proliferating cell nuclear antigen scoring. The other ovary and blood sera were stored at –80°C. TNF-α, total antioxidant status, total oxidant status, and malondialdehyde levels were studied in tissue samples and anti-mullerian hormone levels in blood samples.Results: At the end of the first month, there was

  15. MUSIK DANGDUT KOPLO DI GRUP BHALADIKA SEMARANG DALAM KONTEKS PERUBAHAN SOSIAL BUDAYA

    Directory of Open Access Journals (Sweden)

    Ali Romadhon

    2013-12-01

    Full Text Available Dangdut adalah salah satu jenis musik popular di Indonesia.Menyimak repertoar musik dangdut, tentunya tidak dapat terlepas dari amatan terhadap berbagai elemen musiknya. Kajian terhadap repertoar musik dangdut pada dasarnya merupakan sebuah kajian tentang bentuk dan  struktur musik, pola harmonisasi, orkestrasi, gaya, organologi, dan  sejumlah komponen musik lainnya. Musik dangdut mengalami perkembangan sesuai dengan konteks perkembangan sosial budaya masyarakat.Perkembangan tersebut juga terjadi di grup musik dangdut Bhaladika Semarang. Penelitian ini bertujuan untuk mengetahui dan menganalisis bentuk musik dangdutkoplo di grup Bhaladika Semarang dalam konteks perubahan sosial budaya. Penelitian menggunakan metode kualitatif dengan pendekatanSosio-Budaya Pitirim Sorokin. Dilihat dari bentuknya, bagian utama komposisi musik dangdut umumnya menggunakan  bentuk lagu tiga bagian dengan skema: A, B, A’; A, A’, B, A’;A, A’, B, B’, A’, atau A, B, C. Komposisi musik dangdut terdiri atas bagian introduksi, interlude, dan koda.Pada aspek instrumen ada penambahan alat musik seperti drum setdan adanya perubahan dalam pembawaan gitar, keyboard, kendang. Sementara itu, beberapa hal yang dianggap masih tetap melekat dalam arti tidak berubah adalah gaya pembawaan vokal dangdut, gaya pembawaan suling dan gitar bass yang secara khusus dibawakan di dalam musik dangdutkoplo(2 Pada tahap perkembangannya dangdut dipengaruhi oleh perkembangan industri musik dan adanya tuntutan selera masyarakat. Dangdut is a popular type of music in Indonesia. Listen to dangdut music repertoire, of course, can not be separated from the observations of the various elements of his music. This research is aimed to find out and analyze the form of dangdut koplo in Bhaladika Group Semarang in the contect of social cultural. From its form, it can be seen that the main part generally uses three parts of song with scheme: A, B, A’; A, A’, B, A’; A, A’, B, B’, A

  16. Reporting funding source or conflict of interest in abstracts of randomized controlled trials, no evidence of a large impact on general practitioners' confidence in conclusions, a three-arm randomized controlled trial.

    Science.gov (United States)

    Buffel du Vaure, Céline; Boutron, Isabelle; Perrodeau, Elodie; Ravaud, Philippe

    2014-04-28

    Systematic reporting of funding sources is recommended in the CONSORT Statement for abstracts. However, no specific recommendation is related to the reporting of conflicts of interest (CoI). The objective was to compare physicians' confidence in the conclusions of abstracts of randomized controlled trials of pharmaceutical treatment indexed in PubMed. We planned a three-arm parallel-group randomized trial. French general practitioners (GPs) were invited to participate and were blinded to the study's aim. We used a representative sample of 75 abstracts of pharmaceutical industry-funded randomized controlled trials published in 2010 and indexed in PubMed. Each abstract was standardized and reported in three formats: 1) no mention of the funding source or CoI; 2) reporting the funding source only; and 3) reporting the funding source and CoI. GPs were randomized according to a computerized randomization on a secure Internet system at a 1:1:1 ratio to assess one abstract among the three formats. The primary outcome was GPs' confidence in the abstract conclusions (0, not at all, to 10, completely confident). The study was planned to detect a large difference with an effect size of 0.5. Between October 2012 and June 2013, among 605 GPs contacted, 354 were randomized, 118 for each type of abstract. The mean difference (95% confidence interval) in GPs' confidence in abstract findings was 0.2 (-0.6; 1.0) (P = 0.84) for abstracts reporting the funding source only versus no funding source or CoI; -0.4 (-1.3; 0.4) (P = 0.39) for abstracts reporting the funding source and CoI versus no funding source and CoI; and -0.6 (-1.5; 0.2) (P = 0.15) for abstracts reporting the funding source and CoI versus the funding source only. We found no evidence of a large impact of trial report abstracts mentioning funding sources or CoI on GPs' confidence in the conclusions of the abstracts. ClinicalTrials.gov identifier: NCT01679873.

  17. DELISHUS: an efficient and exact algorithm for genome-wide detection of deletion polymorphism in autism

    Science.gov (United States)

    Aguiar, Derek; Halldórsson, Bjarni V.; Morrow, Eric M.; Istrail, Sorin

    2012-01-01

    Motivation: The understanding of the genetic determinants of complex disease is undergoing a paradigm shift. Genetic heterogeneity of rare mutations with deleterious effects is more commonly being viewed as a major component of disease. Autism is an excellent example where research is active in identifying matches between the phenotypic and genomic heterogeneities. A considerable portion of autism appears to be correlated with copy number variation, which is not directly probed by single nucleotide polymorphism (SNP) array or sequencing technologies. Identifying the genetic heterogeneity of small deletions remains a major unresolved computational problem partly due to the inability of algorithms to detect them. Results: In this article, we present an algorithmic framework, which we term DELISHUS, that implements three exact algorithms for inferring regions of hemizygosity containing genomic deletions of all sizes and frequencies in SNP genotype data. We implement an efficient backtracking algorithm—that processes a 1 billion entry genome-wide association study SNP matrix in a few minutes—to compute all inherited deletions in a dataset. We further extend our model to give an efficient algorithm for detecting de novo deletions. Finally, given a set of called deletions, we also give a polynomial time algorithm for computing the critical regions of recurrent deletions. DELISHUS achieves significantly lower false-positive rates and higher power than previously published algorithms partly because it considers all individuals in the sample simultaneously. DELISHUS may be applied to SNP array or sequencing data to identify the deletion spectrum for family-based association studies. Availability: DELISHUS is available at http://www.brown.edu/Research/Istrail_Lab/. Contact: Eric_Morrow@brown.edu and Sorin_Istrail@brown.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:22689755

  18. Bioprosthetic Valve Fracture to Facilitate Transcatheter Valve-in-Valve Implantation.

    Science.gov (United States)

    Allen, Keith B; Chhatriwalla, Adnan K; Cohen, David J; Saxon, John T; Aggarwal, Sanjeev; Hart, Anthony; Baron, Suzanne; Davis, J Russell; Pak, Alex F; Dvir, Danny; Borkon, A Michael

    2017-11-01

    Valve-in-valve transcatheter aortic valve replacement is less effective in small surgical bioprostheses. We evaluated the feasibility of bioprosthetic valve fracture with a high-pressure balloon to facilitate valve-in-valve transcatheter aortic valve replacement. In vitro bench testing on aortic tissue valves was performed on 19-mm and 21-mm Mitroflow (Sorin, Milan, Italy), Magna and Magna Ease (Edwards Lifesciences, Irvine, CA), Trifecta and Biocor Epic (St. Jude Medical, Minneapolis, MN), and Hancock II and Mosaic (Medtronic, Minneapolis, MN). High-pressure balloons Tru Dilation, Atlas Gold, and Dorado (C.R. Bard, Murray Hill, NJ) were used to determine which valves could be fractured and at what pressure fracture occurred. Mitroflow, Magna, Magna Ease, Mosaic, and Biocor Epic surgical valves were successfully fractured using high-pressures balloon 1 mm larger than the labeled valve size whereas Trifecta and Hancock II surgical valves could not be fractured. Only the internal valve frame was fractured, and the sewing cuff was never disrupted. Manufacturer's rated burst pressures for balloons were exceeded, with fracture pressures ranging from 8 to 24 atmospheres depending on the surgical valve. Testing further demonstrated that fracture facilitated the expansion of previously constrained, underexpanded transcatheter valves (both balloon and self-expanding) to the manufacturer's recommended size. Bench testing demonstrates that the frame of most, but not all, bioprosthetic surgical aortic valves can be fractured using high-pressure balloons. The safety of bioprosthetic valve fracture to optimize valve-in-valve transcatheter aortic valve replacement in small surgical valves requires further clinical investigation. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  19. Immediate Outcomes of Aortic Valve Replacement with Sutureless versus Stentless Bioprosthesis.

    Science.gov (United States)

    Ihsan Parlar, Ali; Onur Hanedan, Muhammet; Mataraci, Ilker; Ali Yuruk, Mehmet; Sayar, Ufuk; Kemal Arslan, Ali; Ozer, Tanil

    2016-01-01

    Aortic valve replacement (AVR) with a sutureless valve is an innovative therapy in high-risk elderly patients. The study aim was to compare the early results of AVR using sutureless aortic valves or stentless aortic bioprostheses. A retrospective analysis was conducted of 55 patients who underwent AVR with either a sutureless valve (Perceval S; n = 24 or Edwards Intuity; n = 9) or a stentless valve (Sorin Freedom SOLO™; n = 22). Baseline patient characteristics were similar in both groups, except for NYHA class. Concomitant procedures were performed in 17 patients (51.5%) of the sutureless group and in nine patients (40.9%) of the stentless group (p = 0.44). The aortic cross-clamp time was 55 ± 23 min in the sutureless group and 102 ± 36 min in the stentless group (p <0.0001), while the postoperative peak aortic gradient was 19.5 ± 5.0 mmHg and 29.3 ± 15.4 mmHg for the sutureless group and stentless group, respectively (p = 0.037). The postoperative mean gradient was 9.3 ± 3.4 mmHg for the sutureless group and 15.1 ± 10.5 mmHg for the stentless group (p = 0.06). Blood product transfusion was required less frequently by the sutureless group, but drainage and bleeding was similar in both groups. The intensive care unit and hospital stays were significantly shorter in favor of the sutureless group. One sutureless patient (3.0%) and two stentless patients (9.1%) died in hospital (p = 0.557). Early results of the present study suggested that surgical AVR with a sutureless valve is associated with a good hemodynamic performance and an improved early outcome.

  20. Nicolae Milescu Spătarul - ancestor of a Nobel Laureate - Ilia I. Mecinikov. Part II. Ilia I. Mecinikov’s life and scientific work; 16th of May 2011 - 166 years since the birth of the European scholar; 15th of July 2011 - 95 years since death

    Directory of Open Access Journals (Sweden)

    Dan RIGA

    2011-01-01

    Full Text Available The work showcases the promotion of Romanian lineage - Nicolae Milescu Spătarul (1636-1708 as ancestor of scientist Ilia Ilici Mecinikov (1845-1916, Nobel Laureate (1908.A great figure in world science and bio-medicine, the scientist - creator of two new modernsciences (immunology and gerontology – is claimed and honoured by four nations: Israeli, French,Russian and Ukrainian. Despite his known Romanian descent on his paternal side – biographicallyconsecrated by his wife Olga Mecinikov – Romania has pushed him into oblivion, by not promotingthis historical truth and reality to all.In our country, Prof. Dr. doc. Ilie Th. Riga (1908-1977 publishes in 1930, in the Romanianmagazine, Natura (Nature, Originea românească a lui Metchnikoff (Metchnikoff’s Romanianorigins. In the 2007-2011 period, two of the authors of the work continuously publish, in thecountry and abroad, thus creating Dosarul ascendenţei româneşti al lui Mecinikov (Mecinikov’sfile on his Romanian lineage, for the global informational civilization. They published their worksin printed version: in scientific magazines (2007, 2011, in their own monograph Medicina antiîmbătrânireşi ştiinţele longevităţii (Anti-aging Medicine and Longevity Sciences, (2007, innewspapers Ziua USA (The Day - USA, (2008 and Clipa. Magazinul Actualităţii CulturaleRomâneşti (The Moment. The Romanian Cultural Current Affairs Magazine, (2011, inEnciclopedia medicală Românească (Encyclopaedia of Romanian Medicine, (2009 and also onSorin Riga, Dan Riga, Vasile Man - Nicolae Milescu Spătarul - ancestor of a Nobel Laureate - Ilia I. Mecinikov...250webpages (the online era: www.DacoRomanica.ro (2010, www.revista-studii-uvvg.ro (2011,www.ziuausa.com (2008, www.revistaclipa.com (2011, taken over by other internet websites.

  1. Integrable scalar cosmologies

    International Nuclear Information System (INIS)

    Fré, P.; Sorin, A.S.; Trigiante, M.

    2014-01-01

    The question whether the integrable one-field cosmologies classified in a previous paper by Fré, Sagnotti and Sorin can be embedded as consistent one-field truncations into Extended Gauged Supergravity or in N=1 supergravity gauged by a superpotential without the use of D-terms is addressed in this paper. The answer is that such an embedding is very difficult and rare but not impossible. Indeed, we were able to find two examples of integrable models embedded in supergravity in this way. Both examples are fitted into N=1 supergravity by means of a very specific and interesting choice of the superpotential W(z). The question whether there are examples of such an embedding in Extended Gauged Supergravity remains open. In the present paper, relying on the embedding tensor formalism we classified all gaugings of the N=2 STU model, confirming, in the absence on hypermultiplets, the uniqueness of the stable de Sitter vacuum found several years ago by Fré, Trigiante and Van Proeyen and excluding the embedding of any integrable cosmological model. A detailed analysis of the space of exact solutions of the first supergravity-embedded integrable cosmological model revealed several new features worth an in-depth consideration. When the scalar potential has an extremum at a negative value, the Universe necessarily collapses into a Big Crunch notwithstanding its spatial flatness. The causal structure of these Universes is quite different from that of the closed, positive curved, Universe: indeed, in this case the particle and event horizons do not coincide and develop complicated patterns. The cosmological consequences of this unexpected mechanism deserve careful consideration

  2. Coronary artery assessment by multidetector computed tomography in patients with prosthetic heart valves

    International Nuclear Information System (INIS)

    Habets, Jesse; Mali, Willem P.T.M.; Budde, Ricardo P.J.; Brink, Renee B.A. van den; Uijlings, Ruben; Spijkerboer, Anje M.; Chamuleau, Steven A.J.

    2012-01-01

    Patients with prosthetic heart valves may require assessment for coronary artery disease. We assessed whether valve artefacts hamper coronary artery assessment by multidetector CT. ECG-gated or -triggered CT angiograms were selected from our PACS archive based on the presence of prosthetic heart valves. The best systolic and diastolic axial reconstructions were selected for coronary assessment. Each present coronary segment was scored for the presence of valve-related artefacts prohibiting coronary artery assessment. Scoring was performed in consensus by two observers. Eighty-two CT angiograms were performed on a 64-slice (n = 27) or 256-slice (n = 55) multidetector CT. Eighty-nine valves and five annuloplasty rings were present. Forty-three out of 1160 (3.7%) present coronary artery segments were non-diagnostic due to valve artefacts (14/82 patients). Valve artefacts were located in right coronary artery (15/43; 35%), left anterior descending artery (2/43; 5%), circumflex artery (14/43; 32%) and marginal obtuse (12/43; 28%) segments. All cobalt-chrome containing valves caused artefacts prohibiting coronary assessment. Biological and titanium-containing valves did not cause artefacts except for three specific valve types. Most commonly implanted prosthetic heart valves do not hamper coronary assessment on multidetector CT. Cobalt-chrome containing prosthetic heart valves preclude complete coronary artery assessment because of severe valve artefacts. circle Most commonly implanted prosthetic heart valves do not hamper coronary artery assessment circle Prosthetic heart valve composition determines the occurrence of prosthetic heart valve-related artefacts circle Bjoerk-Shiley and Sorin tilting disc valves preclude diagnostic coronary artery segment assessment. (orig.)

  3. Single-center experience using the Freedom SOLO aortic bioprosthesis.

    Science.gov (United States)

    Iliopoulos, Dimitrios C; Deveja, Aris Rezar; Androutsopoulou, Vasiliki; Filias, Vasilios; Kastelanos, Eleftherios; Satratzemis, Vasilios; Khalpey, Zain; Koudoumas, Dimitrios

    2013-07-01

    This study reviews a single institution experience with the Freedom SOLO (Sorin Group, Saluggia, Italy) aortic bioprosthesis. Between October 2006 and February 2010, 128 patients (64 men, 64 women; mean age, 75.8 ± 5.1 years) underwent aortic valve replacement using the Freedom SOLO stentless aortic valve. The follow-up time was 36.7 ± 1.2 months and 100% complete. Concomitant procedures were performed in 77 patients (60%). The mean standard European System for Cardiac Operative Risk Evaluation was 9 ± 2.7. Grade 3 aortic stenosis was present in 73% of patients, mixed aortic stenosis and regurgitation were present in 40% of patients, and mitral regurgitation was present in 46% of patients. The mean crossclamp time was 53 ± 12 minutes for isolated Freedom SOLO aortic valve implantation and 80 ± 28 minutes for concomitant procedures, and the mean cardiopulmonary bypass time was 103 ± 31 minutes. The mean implanted valve size was 22.6 ± 1.4 mm. The mean intensive care unit and hospital stays were 2.4 ± 1.1 days and 8.8 ± 2.6 days, respectively. Three patients underwent reoperation for bleeding. The 15-day, 30-day, and perioperative mortality were all 4.6%. The 36-month survival was 95.4% ± 1.6% for the cohort with a low European System for Cardiac Operative Risk Evaluation (9). Echocardiographic data preoperatively, immediately postoperatively, and at 3, 6, and 12 months postoperatively showed peak transvalvular gradients of 75 ± 23, 17 ± 6, 18 ± 6.5, 16 ± 6, and 16 ± 9 mm Hg, respectively (P SOLO stentless aortic valve has excellent early and intermediate-term results. Published by Mosby, Inc.

  4. 19 mm sized bileaflet valve prostheses' flow field investigated by bidimensional laser Doppler anemometry (part II: maximum turbulent shear stresses)

    Science.gov (United States)

    Barbaro, V; Grigioni, M; Daniele, C; D'Avenio, G; Boccanera, G

    1997-11-01

    The investigation of the flow field generated by cardiac valve prostheses is a necessary task to gain knowledge on the possible relationship between turbulence-derived stresses and the hemolytic and thrombogenic complications in patients after valve replacement. The study of turbulence flows downstream of cardiac prostheses, in literature, especially concerns large-sized prostheses with a variable flow regime from very low up to 6 L/min. The Food and Drug Administration draft guidance requires the study of the minimum prosthetic size at a high cardiac output to reach the maximum Reynolds number conditions. Within the framework of a national research project regarding the characterization of cardiovascular endoprostheses, an in-depth study of turbulence generated downstream of bileaflet cardiac valves is currently under way at the Laboratory of Biomedical Engineering of the Istituto Superiore di Sanita. Four models of 19 mm bileaflet valve prostheses were used: St Jude Medical HP, Edwards Tekna, Sorin Bicarbon, and CarboMedics. The prostheses were selected for the nominal Tissue Annulus Diameter as reported by manufacturers without any assessment of valve sizing method, and were mounted in aortic position. The aortic geometry was scaled for 19 mm prostheses using angiographic data. The turbulence-derived shear stresses were investigated very close to the valve (0.35 D0), using a bidimensional Laser Doppler anemometry system and applying the Principal Stress Analysis. Results concern typical turbulence quantities during a 50 ms window at peak flow in the systolic phase. Conclusions are drawn regarding the turbulence associated to valve design features, as well as the possible damage to blood constituents.

  5. Follow-up of pregnant women exposed to chicken pox: an audit of relationship between level of antibody and development of chicken pox.

    Science.gov (United States)

    Boxall, E H; Maple, P A C; Rathod, P; Smit, E

    2011-10-01

    The purpose of this study was to validate through natural exposure a cut-off level of varicella zoster IgG as protective against infection with varicella zoster virus (VZV). Laboratory testing to determine VZV immune status of pregnant women exposed to varicella is recommended. Quantitative assays are now available which are sensitive and specific. More than 200 consecutive requests for screening in pregnant patients with recent varicella contacts were followed-up by questionnaire. DiaSorin LIAISON and VZV time resolved fluorescence immuno assay (VZV TRFIA) were used to measure VZV antibody level. One hundred fifty out of 209 (72%) questionnaires were returned; 14 patients developed varicella, 129 did not and seven were not known. Patients who had been given VZIG and developed varicella on follow-up had a mean antibody level before VZIG of 28 mIU/ml and 62 mIU/ml, by LIAISON and TRFIA, respectively. The mean IgG level of those that did not develop varicella was 885 and 866 mIU/ml by LIAISON and TRFIA, respectively. Those with levels pox than those with levels >100 mIU/ml (relative risk of 10.4 for LIAISON and 8.8 for TRFIA). On the basis of the relatively small numbers in this study, quantitative assays, using a 100mIU/ml cut-off, can differentiate between those who are susceptible and those who are protected against exposure, however follow-up studies should include sampling for VZV DNA and IgM.

  6. Annular dynamics after mitral valve repair with different prosthetic rings: A real-time three-dimensional transesophageal echocardiography study.

    Science.gov (United States)

    Nishi, Hiroyuki; Toda, Koichi; Miyagawa, Shigeru; Yoshikawa, Yasushi; Fukushima, Satsuki; Kawamura, Masashi; Yoshioka, Daisuke; Saito, Tetsuya; Ueno, Takayoshi; Kuratani, Toru; Sawa, Yoshiki

    2016-09-01

    We assessed the effects of different types of prosthetic rings on mitral annular dynamics using real-time three-dimensional echocardiography (RT3DE). RT3DE was performed in 44 patients, including patients undergoing mitral annuloplasty using the Cosgrove-Edwards flexible band (Group A, n = 10), the semi-rigid Sorin Memo 3D ring (Group B, n = 17), the semi-rigid Edwards Physio II ring (Group C, n = 7) and ten control subjects. Various annular diameters were measured throughout the cardiac cycle. We observed flexible anterior annulus motion in all of the groups except Group C. A flexible posterior annulus was only observed in Group B and the Control group. The mitral annular area changed during the cardiac cycle by 8.4 ± 3.2, 6.3 ± 2.0, 3.2 ± 1.3, and 11.6 ± 5.0 % in Group A, Group B, Group C, and the Control group, respectively. The dynamic diastolic to systolic change in mitral annular diameters was lost in Group C, while it was maintained in Group A, and to a good degree in Group B. In comparison to the Control group, the mitral annulus shape was more ellipsoid in Group B and Group C, and more circular in Group A. Although mitral regurgitation was well controlled by all of the types of rings that were utilized in the present study, we demonstrated that the annulus motion and annulus shape differed according to the type of prosthetic ring that was used, which might provide important information for the selection of an appropriate prosthetic ring.

  7. Comparing Perspectives: Writing about Communist Architecture and Urbanism at the Seaside

    Directory of Open Access Journals (Sweden)

    Dana Vais

    2016-10-01

    Full Text Available The review compares two recent books: Holidays after the Fall. Seaside Architecture and Urbanism in Bulgaria and Croatia (edited by Elke Beyer, Anke Hagemann and Michael Zinganel, Berlin, 2013 and Enchanting Views. Romanian Black Sea Tourism Planning and Architecture of the 1960s and 70s (edited by Kalliopi Dimou, Sorin Istudor and Alina Serban, Bucharest, 2015. They are the first comprehensive publications that focus on seaside tourism architecture and urbanism in the former communist world, in the three countries where these have been most substantially developed at the time. The two books are also part of a tendency in recent literature on the communist period, to see the brighter side of a built environment that is still generally considered to be grey and dull. The review compares the two editorial strategies and stresses their differences: Holidays after the Fall addresses both the communist and the post-communist periods, including the ‘architectural monstrosities’ of the recent liberal developments; Enchanting Views focuses strictly on the 1960s and the 1970s, with their unspoiled image of a clean and pure modernist seaside environment. Holidays after the Fall focuses more on researching and revealing objects of architecture and urbanism, while Enchanting Views looks to display as many different disciplinary perspectives and interpretations as possible.The review highlights their similarities too: both books develop comparative approaches, showing that modernist seaside developments in the communist Europe were closely similar to their Western counterparts and that seaside resorts have played a major role as instruments of lifestyle change and modernization.

  8. Analytical Bias in the Measurement of Serum 25-Hydroxyvitamin D Concentrations Impairs Assessment of Vitamin D Status in Clinical and Research Settings.

    Directory of Open Access Journals (Sweden)

    Lucinda J Black

    Full Text Available Measured serum 25-hydroxyvitamin D concentrations vary depending on the type of assay used and the specific laboratory undertaking the analysis, impairing the accurate assessment of vitamin D status. We investigated differences in serum 25-hydroxyvitamin D concentrations measured at three laboratories (laboratories A and B using an assay based on liquid chromatography-tandem mass spectrometry and laboratory C using a DiaSorin Liaison assay, against a laboratory using an assay based on liquid chromatography-tandem mass spectrometry that is certified to the standard reference method developed by the National Institute of Standards and Technology and Ghent University (referred to as the 'certified laboratory'. Separate aliquots from the same original serum sample for a subset of 50 participants from the Ausimmune Study were analysed at the four laboratories. Bland-Altman plots were used to visually check agreement between each laboratory against the certified laboratory. Compared with the certified laboratory, serum 25-hydroxyvitamin D concentrations were on average 12.4 nmol/L higher at laboratory A (95% limits of agreement: -17.8,42.6; 12.8 nmol/L higher at laboratory B (95% limits of agreement: 0.8,24.8; and 10.6 nmol/L lower at laboratory C (95% limits of agreement: -48.4,27.1. The prevalence of vitamin D deficiency (defined here as 25-hydroxyvitamin D <50 nmol/L was 24%, 16%, 12% and 41% at the certified laboratory, and laboratories A, B, and C, respectively. Our results demonstrate considerable differences in the measurement of 25-hydroxyvitamin D concentrations compared with a certified laboratory, even between laboratories using assays based on liquid chromatography-tandem mass spectrometry, which is often considered the gold-standard assay. To ensure accurate and reliable measurement of serum 25-hydroxyvitamin D concentrations, all laboratories should use an accuracy-based quality assurance system and, ideally, comply with international

  9. The prevalence of isolated growth hormone deficiency among children of short stature in Jordan and its relationship with consanguinity.

    Science.gov (United States)

    Zayed, Ayman A; Mustafa Ali, Moaath K; Al-Ani, Mohammad A; Momani, Munther S; Yousef, Al-Motassem F

    2014-12-01

    The prevalence of isolated growth hormone deficiency (IGHD) among short-statured children in Jordan, where consanguineous marriage (CM) is common, is unknown. No studies have investigated the relationship between degrees of consanguinity and IGHD. This study aimed to determine the prevalence of IGHD among short-statured children referred to a university hospital in Jordan and its relationship with different degrees of consanguinity. We conducted a 24-month cross-sectional observational trial at an outpatient tertiary care center in Amman, Jordan. We obtained detailed family histories, medical evaluations and laboratory tests for 94 short-statured children (50 boys and 44 girls aged 6-16 years). Complete and partial GHD were defined as peak GH responses of 5 and 7 μg/l (15 and 21 mIU/l) [IRMA/DiaSorin®], respectively, in both exercise and insulin tolerance tests. GHD was diagnosed in 69·1% of the short children, including 86% (43/50) of the children of consanguineous parents (83·3%, 93·8% and 81·8% of children of first cousins, first cousins once removed and second cousins, respectively) and 50% (20/44) of the children of nonconsanguineous parents (P = 0·039, 0·002 and 0·013, respectively). However, there was no statistically significant difference in the prevalence of small pituitary MRI between GH-deficient children of consanguineous parents and those of nonconsanguineous parents (28·6% vs 13·6%, P = 0·3). The prevalence of IGHD among referred short children in Jordan was exceptionally high and significantly higher in the children of CM. In countries where CM is common, preconception counselling and rigorous surveillance for GHD in short children may be indicated. © 2014 John Wiley & Sons Ltd.

  10. Development and validation of a novel algorithm based on the ECG magnet response for rapid identification of any unknown pacemaker.

    Science.gov (United States)

    Squara, Fabien; Chik, William W; Benhayon, Daniel; Maeda, Shingo; Latcu, Decebal Gabriel; Lacaze-Gadonneix, Jonathan; Tibi, Thierry; Thomas, Olivier; Cooper, Joshua M; Duthoit, Guillaume

    2014-08-01

    Pacemaker (PM) interrogation requires correct manufacturer identification. However, an unidentified PM is a frequent occurrence, requiring time-consuming steps to identify the device. The purpose of this study was to develop and validate a novel algorithm for PM manufacturer identification, using the ECG response to magnet application. Data on the magnet responses of all recent PM models (≤15 years) from the 5 major manufacturers were collected. An algorithm based on the ECG response to magnet application to identify the PM manufacturer was subsequently developed. Patients undergoing ECG during magnet application in various clinical situations were prospectively recruited in 7 centers. The algorithm was applied in the analysis of every ECG by a cardiologist blinded to PM information. A second blinded cardiologist analyzed a sample of randomly selected ECGs in order to assess the reproducibility of the results. A total of 250 ECGs were analyzed during magnet application. The algorithm led to the correct single manufacturer choice in 242 ECGs (96.8%), whereas 7 (2.8%) could only be narrowed to either 1 of 2 manufacturer possibilities. Only 2 (0.4%) incorrect manufacturer identifications occurred. The algorithm identified Medtronic and Sorin Group PMs with 100% sensitivity and specificity, Biotronik PMs with 100% sensitivity and 99.5% specificity, and St. Jude and Boston Scientific PMs with 92% sensitivity and 100% specificity. The results were reproducible between the 2 blinded cardiologists with 92% concordant findings. Unknown PM manufacturers can be accurately identified by analyzing the ECG magnet response using this newly developed algorithm. Copyright © 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  11. Stentless vs. stented bioprosthesis for aortic valve replacement: A case matched comparison of long-term follow-up and subgroup analysis of patients with native valve endocarditis.

    Science.gov (United States)

    Schaefer, Andreas; Dickow, Jannis; Schoen, Gerhard; Westhofen, Sumi; Kloss, Lisa; Al-Saydali, Tarik; Reichenspurner, Hermann; Philipp, Sebastian A; Detter, Christian

    2018-01-01

    Current retrospective evidence suggests similar clinical and superior hemodynamic outcomes of the Sorin Freedom Solo stentless aortic valve (SFS) (LivaNova PLC, London, UK) compared to the Carpentier Edwards Perimount stented aortic valve (CEP) (Edwards Lifesciences Inc., Irvine, California, USA). To date, no reports exist describing case-matched long-term outcomes and analysis for treatment of native valve endocarditis (NVE). From 2004 through 2014, 77 consecutive patients (study group, 59.7% male, 68.9 ± 12.5 years, logEuroSCORE II 7.6 ± 12.3%) received surgical aortic valve replacement (SAVR) with the SFS. A control group of patients after SAVR with the CEP was retrieved from our database and matched to the study group regarding 15 parameters including preoperative endocarditis. Acute perioperative outcomes and follow-up data (mean follow-up time 48.7±29.8 months, 95% complete) were retrospectively analyzed. No differences in early mortality occurred during 30-day follow up (3/77; 3.9% vs. 4/77; 5.2%; p = 0.699). Echocardiographic findings revealed lower postprocedural transvalvular pressure gradients (max. 17.0 ± 8.2 vs. 24.5 ± 9.2 mmHg, pendocarditis (PVE) (9.1% vs. 1.3%; p = 0.04) was more frequent in the SFS group. All-cause mortality during follow-up was 20.8% vs. 14.3% (p = 0.397). When patients were divided into subgroups of NVE and respective utilized bioprosthesis, the SFS presented impaired outcomes regarding mortality in NVE cases (p = 0.031). The hemodynamic superiority of the SFS was confirmed in this comparison. However, clinical outcomes in terms of SVD and PVE rates, as well as survival after NVE, were inferior in this study. Therefore, we are reluctant to recommend utilization of the SFS for treatment of NVE.

  12. Serological and molecular evidence of hepadnavirus infection in swine

    Directory of Open Access Journals (Sweden)

    Yasmine R Vieira

    2015-02-01

    Full Text Available [b]Introduction and objective[/b]. Recently, investigations in a swine herd identified evidence of the existence of a novel member of the Hepadnavirus family endemic in swine. The aim of this study was to investigate the serological and molecular markers of Hepadnavirus circulation in Brazilian domestic swine and wild boar herds, and to evaluate the identity with HBV and other Hepadnaviruses reported previously. [b]Materials and methods[/b]. For the study, 376 swine were screened for hepatitis B virus serological markers. Analyses were performed in serum samples using commercial enzyme-linked immunosorbent assay (ELISA kits (DiaSorin® for anti-HBc, HBsAg and anti-HBs. Reactive and undetermined swine serum samples were selected to perform DNA viral extraction (QIAamp DNA Mini Kit, Qiagen®, partial genome amplification and genome sequencing. [b]Results[/b]. From 376 swine samples analysed, 28 (7.45% were reactive to anti-HBc, 3 (0.80% to HBsAg and 6 (1.6% to anti-HBs. Besides, more 17 (4.52% swine samples analyzed were classified in the grey zone of the EIA test to anti-HBc and 2 (0.53% to HBsAg. From 49 samples molecularly analyzed after serological trial, 4 samples showed a positive result for the qualitative PCR for Hepadnavirus. Phylogenetic reconstruction using partial genome sequencing (360 bp of 3 samples showed similarity with HBV with 90.8–96.3% of identity. [b]Conclusions.[/b] Serological and molecular data showed evidence of the circulation of a virus similar to hepatitis B virus in swine.

  13. Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study.

    Science.gov (United States)

    van Ingen, Jakko; Kohl, Thomas A; Kranzer, Katharina; Hasse, Barbara; Keller, Peter M; Katarzyna Szafrańska, Anna; Hillemann, Doris; Chand, Meera; Schreiber, Peter Werner; Sommerstein, Rami; Berger, Christoph; Genoni, Michele; Rüegg, Christian; Troillet, Nicolas; Widmer, Andreas F; Becker, Sören L; Herrmann, Mathias; Eckmanns, Tim; Haller, Sebastian; Höller, Christiane; Debast, Sylvia B; Wolfhagen, Maurice J; Hopman, Joost; Kluytmans, Jan; Langelaar, Merel; Notermans, Daan W; Ten Oever, Jaap; van den Barselaar, Peter; Vonk, Alexander B A; Vos, Margreet C; Ahmed, Nada; Brown, Timothy; Crook, Derrick; Lamagni, Theresa; Phin, Nick; Smith, E Grace; Zambon, Maria; Serr, Annerose; Götting, Tim; Ebner, Winfried; Thürmer, Alexander; Utpatel, Christian; Spröer, Cathrin; Bunk, Boyke; Nübel, Ulrich; Bloemberg, Guido V; Böttger, Erik C; Niemann, Stefan; Wagner, Dirk; Sax, Hugo

    2017-10-01

    Since 2013, over 100 cases of Mycobacterium chimaera prosthetic valve endocarditis and disseminated disease were notified in Europe and the USA, linked to contaminated heater-cooler units (HCUs) used during cardiac surgery. We did a molecular epidemiological investigation to establish the source of these patients' disease. We included 24 M chimaera isolates from 21 cardiac surgery-related patients in Switzerland, Germany, the Netherlands, and the UK, 218 M chimaera isolates from various types of HCUs in hospitals, from LivaNova (formerly Sorin; London, UK) and Maquet (Rastatt, Germany) brand HCU production sites, and unrelated environmental sources and patients, as well as eight Mycobacterium intracellulare isolates. Isolates were analysed by next-generation whole-genome sequencing using Illumina and Pacific Biosciences technologies, and compared with published M chimaera genomes. Phylogenetic analysis based on whole-genome sequencing of 250 isolates revealed two major M chimaera groups. Cardiac surgery-related patient isolates were all classified into group 1, in which all, except one, formed a distinct subgroup. This subgroup also comprised isolates from 11 cardiac surgery-related patients reported from the USA, most isolates from LivaNova HCUs, and one from their production site. Isolates from other HCUs and unrelated patients were more widely distributed in the phylogenetic tree. HCU contamination with M chimaera at the LivaNova factory seems a likely source for cardiothoracic surgery-related severe M chimaera infections diagnosed in Switzerland, Germany, the Netherlands, the UK, the USA, and Australia. Protective measures and heightened clinician awareness are essential to guarantee patient safety. Partly funded by the EU Horizon 2020 programme, its FP7 programme, the German Center for Infection Research (DZIF), the Swiss National Science Foundation, the Swiss Federal Office of Public Health, and National Institute of Health Research Oxford Health Protection

  14. Comparison of the Vidas System and Two Recent Fully Automated Assays for Diagnosis and Follow-Up of Toxoplasmosis in Pregnant Women and Newborns

    Science.gov (United States)

    Dard, Céline; Fricker Hidalgo, Hélène; Dardé, Marie-Laure; Brenier-Pinchart, Marie-Pierre; Pelloux, Hervé

    2013-01-01

    Serological testing to detect toxoplasmosis is of major importance to avoid the possible effects of the disease in newborns. This study assessed anti-Toxoplasma IgG and IgM with the Vidas (bioMérieux), Architect (Abbott), and Liaison (DiaSorin) systems in 631 sera from pregnant women and newborns as well as anti-Toxoplasma IgG avidity with these three systems on 54 sera from pregnant women with positive IgG and IgM. The IgG and IgM results were in agreement in, respectively, 95.2% and 98.3% (Vidas versus Architect) and 96.9% and 95.3% (Vidas versus Liaison) of the samples. Specificities were excellent for all the assays, while Vidas sensitivities ranged (depending on the classification of gray zone results) from 93.8 to 98.4% for IgG (Architect, 84.4 to 93.8%; Liaison, 93.8%) and from 81.8 to 90.9% for IgM (Architect, 63.6%; Liaison, 81.8 to 90.9%). In seroconversion sequences, IgMs were generally detected simultaneously by the three assays, while Architect was the earliest assay to detect IgG. In noninfected children, maternally transmitted IgGs were detected for a longer time with Architect than with the other systems. IgMs were positive in only one infected child with the Vidas and Liaison systems. Significantly more sera were classified in the high-avidity category with Vidas than with Architect. This evaluation shows similar performances for Vidas and more recent systems. The Vidas system adequately detects toxoplasmosis in pregnant women and newborns. This system fits the needs of laboratories working on small routine series for first-line testing as well as expert laboratories, due to a high specificity and a powerful avidity test. PMID:23740928

  15. Effect of 25-Hydroxyvitamin D Status on Serological Response to Influenza Vaccine in Prostate Cancer Patients

    Science.gov (United States)

    Chadha, Manpreet K.; Fakih, Marwan; Muindi, Josephia; Tian, Lili; Mashtare, Terry; Johnson, Candace S.; Trump, Donald

    2015-01-01

    BACKGROUND Epidemiologic data suggest that there is an association between vitamin D deficiency and influenza infection. We conducted a prospective influenza vaccination study to determine the influence of vitamin D status on serological response to influenza vaccine in prostate cancer (CaP) patients. METHODS During the 2006–2007 influenza season, CaP patients treated at Roswell Park Cancer Institute were offered vaccination with the trivalent influenza vaccine (Fluzone®, 2006–2007) and sera collected for hemagglutination inhibition (HI) assay titers before and 3 months after vaccination. Response to vaccination was defined as ≥1:40 titer ratio or a fourfold increase in titer at 3 months, against any of the three strains. Serum 25-hydroxyvitamin D (25-D3) levels were measured using DiaSorin 125I radioimmunoassay kits. RESULTS Thirty-five patients with CaP participated in the study. Median baseline 25-D3 level was 44.88 ng/ml (range: 9.16–71.98 ng/ml) Serological response against any of the three strains was noted in 80%. There was a significant effect of baseline 25-D3 level when tested as a continuous variable in relation to serological response (P = 0.0446). All patients in the upper quartile of 25-D3 level responded by mounting a serological response (P = 0.0344). None of the other baseline variables (age, race, chemotherapy status, or white cell count) had an effect on serological response. CONCLUSIONS In this study in CaP patients, a replete vitamin D status was associated with more frequent serological response to influenza vaccine. PMID:20812224

  16. A novel bi-level meta-analysis approach: applied to biological pathway analysis.

    Science.gov (United States)

    Nguyen, Tin; Tagett, Rebecca; Donato, Michele; Mitrea, Cristina; Draghici, Sorin

    2016-02-01

    The accumulation of high-throughput data in public repositories creates a pressing need for integrative analysis of multiple datasets from independent experiments. However, study heterogeneity, study bias, outliers and the lack of power of available methods present real challenge in integrating genomic data. One practical drawback of many P-value-based meta-analysis methods, including Fisher's, Stouffer's, minP and maxP, is that they are sensitive to outliers. Another drawback is that, because they perform just one statistical test for each individual experiment, they may not fully exploit the potentially large number of samples within each study. We propose a novel bi-level meta-analysis approach that employs the additive method and the Central Limit Theorem within each individual experiment and also across multiple experiments. We prove that the bi-level framework is robust against bias, less sensitive to outliers than other methods, and more sensitive to small changes in signal. For comparative analysis, we demonstrate that the intra-experiment analysis has more power than the equivalent statistical test performed on a single large experiment. For pathway analysis, we compare the proposed framework versus classical meta-analysis approaches (Fisher's, Stouffer's and the additive method) as well as against a dedicated pathway meta-analysis package (MetaPath), using 1252 samples from 21 datasets related to three human diseases, acute myeloid leukemia (9 datasets), type II diabetes (5 datasets) and Alzheimer's disease (7 datasets). Our framework outperforms its competitors to correctly identify pathways relevant to the phenotypes. The framework is sufficiently general to be applied to any type of statistical meta-analysis. The R scripts are available on demand from the authors. sorin@wayne.edu Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e

  17. Multi-material micro-electromechanical fibers with bendable functional domains

    Science.gov (United States)

    Nguyen-Dang, Tung; Page, Alexis G.; Qu, Yunpeng; Volpi, Marco; Yan, Wei; Sorin, Fabien

    2017-04-01

    The integration of increasingly complex functionalities within thermally drawn multi-material fibers is heralding a novel path towards advanced soft electronics and smart fabrics. Fibers capable of electronic, optoelectronic, piezoelectric or energy harvesting functions are created by assembling new materials in intimate contact within increasingly complex architectures. Thus far, however, the opportunities associated with the integration of cantilever-like structures with freely moving functional domains within multi-material fibers have not been explored. Used extensively in the micro-electromechanical system (MEMS) technology, electro-mechanical transductance from moving and bendable domains is used in a myriad of applications. In this article we demonstrate the thermal drawing of micro-electromechanical fibers (MEMF) that can detect and localize pressure with high accuracy along their entire length. This ability results from an original cantilever-like design where a freestanding electrically conductive polymer composite film bends under an applied pressure. As it comes into contact with another conducting domain, placed at a prescribed position in the fiber cross-section, an electrical signal is generated. We show that by a judicious choice of materials and electrical connectivity, this signal can be uniquely related to a position along the fiber axis. We establish a model that predicts the position of a local touch from the measurement of currents generated in the 1D MEMF device, and demonstrate an excellent agreement with the experimental data. This ability to detect and localize touch over large areas, curved surfaces and textiles holds significant opportunities in robotics and prosthetics, flexible electronic interfaces, and medical textiles. , which features invited work from the best early-career researchers working within the scope of J. Phys. D. This project is part of the Journal of Physics series’ 50th anniversary celebrations in 2017. Fabien Sorin

  18. Verification of Abbott 25-OH-vitamin D assay on the architect system

    Directory of Open Access Journals (Sweden)

    Katrina Hutchinson

    2017-04-01

    Full Text Available Objectives: Analytical and clinical verification of both old and new generations of the Abbott total 25-hydroxyvitamin D (25OHD assays, and an examination of reference Intervals. Methods: Determination of between-run precision, and Deming comparison between patient sample results for 25OHD on the Abbott Architect, DiaSorin Liaison and AB SCIEX API 4000 (LC-MS/MS. Establishment of uncertainty of measurement for 25OHD Architect methods using old and new generations of the reagents, and estimation of reference interval in healthy Irish population. Results: For between-run precision the manufacturer claims 2.8% coefficients of variation (CVs of 2.8% and 4.6% for their high and low controls, respectively. Our instrument showed CVs between 4% and 6.2% for all levels of the controls on both generations of the Abbott reagents. The between-run uncertainties were 0.28 and 0.36, with expanded uncertainties 0.87 and 0.98 for the old and the new generations of reagent, respectively. The difference between all methods used for patients’ samples was within total allowable error, and the instruments produced clinically equivalent results. The results covered the medical decision points of 30, 40, 50 and 125 nmol/L. The reference interval for total 25OHD in our healthy Irish subjects was lower than recommended levels (24–111 nmol/L. Conclusion: In a clinical laboratory Abbott 25OHD immunoassays are a useful, rapid and accurate method for measuring total 25OHD. The new generation of the assay was confirmed to be reliable, accurate, and a good indicator for 25OHD measurement. More study is needed to establish reference intervals that correctly represent the healthy population in Ireland.

  19. Conflict of interest: A tenacious ethical dilemma in public health ...

    African Journals Online (AJOL)

    In addition to the ethical practice of individual health professionals, bioethical debate about conflict of interest (CoI) must include the institutional ethics of public policy-making, as failure to establish independence from powerful stakeholder influence may pervert public health goals. All involved in public policy processes are ...

  20. Examining the Reliability and Validity of a Turkish Version of the Community of Inquiry Survey

    Science.gov (United States)

    Olpak, Yusuf Ziya; Kiliç Çakmak, Ebru

    2018-01-01

    The aim of this study was to describe the validity and reliability of a Turkish language version of the CoI survey developed by Arbaugh et al. (2008). Data were obtained from 1150 students enrolled in online courses in various departments in three Turkish state universities. The data were randomly divided into two parts: the first part was…

  1. Collaborative improvement: What do we know? Where do we need to go?

    NARCIS (Netherlands)

    Middel, H.G.A.; Boer, Harm; Fisscher, O.A.M.

    2005-01-01

    Although especially through research performed across the CINet community, a lot of theoretical and practical knowledge has been developed on intra-firm continuous improvement, there is still a substantial lack of empirically grounded contributions and theories on collaborative improvement (CoI),

  2. Phylogenetic relationships in the "grossulariae" species group of the genus Aphis (Hemiptera: Sternorrhyncha: Aphididae): Molecular evidence

    DEFF Research Database (Denmark)

    Turcinaviciene, Jorga; Rakauskas, Rimantas; Pedersen, Bo Vest

    2006-01-01

    Phylogenetic relationships among Palaearctic Ribes and/or Onagraceae inhabiting Aphis species from five countries were examined using mitochondrial gene cytochrome oxidase I (CO-I) and nuclear gene elongation factor 1 a (EF-1a) sequences. There was no major conflict between the trees obtained fro...

  3. Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation

    DEFF Research Database (Denmark)

    Henrichs, Sina; Wang, Bangjun; Fukao, Yoichiro

    2012-01-01

    Polar transport of the plant hormone auxin is controlled by PIN-and ABCB/PGP-efflux catalysts. PIN polarity is regulated by the AGC protein kinase, PINOID (PID), while ABCB activity was shown to be dependent on interaction with the FKBP42, TWISTED DWARF1 (TWD1). Using co-immunoprecipitation (co-I...

  4. Community of Inquiry and Video in Higher Education: Engaging Students Online

    Science.gov (United States)

    Conrad, Oliver

    2015-01-01

    The purpose of this literature review was to explore how video technology can be effectively used in an online classroom setting. The author found and cited online journals with information about the Community of Inquiry (CoI) framework. He further explored specific sources that could give readers an idea how online video technology can affect…

  5. EST Table: FS839039 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS839039 E_FL_fner_05J12_F_0 10/09/28 57 %/212 aa gb|ADE18444.1| cytochrome c oxida...se subunit I [Bombyx mori] 10/09/10 50 %/212 aa FBpp0100176|mt:CoI-PA 10/08/29 39 %/207 aa MTCE.26#CE35350#W

  6. The Community of Inquiry Framework Meets the SOLO Taxonomy: A Process-Product Model of Online Learning

    Science.gov (United States)

    Shea, Peter; Gozza-Cohen, Mary; Uzuner, Sedef; Mehta, Ruchi; Valtcheva, Anna Valentinova; Hayes, Suzanne; Vickers, Jason

    2011-01-01

    This paper presents both a conceptual and empirical investigation of teaching and learning in online courses. Employing both the Community of Inquiry framework (CoI) and the Structure of Observed Learning Outcomes (SOLO) taxonomy, two complete online courses were examined for the quality of both collaborative learning processes and learning…

  7. Comparing Communities of Inquiry of Portuguese Higher Education Students: One for All or One for Each?

    Science.gov (United States)

    Moreira, José António; Ferreira, António Gomes; Almeida, Ana Cristina

    2013-01-01

    The purpose of this study was to report evidence obtained in a survey based on the Community of Inquiry (CoI) framework (Garrison, Anderson & Archer, 1991; 2000) carried out in different groups. The study comprised 510 higher education students enrolled in blended online courses offered through Moodle platform during one semester. It…

  8. Cobalt(III)-catalyzed alkenylation of arenes and 6-arylpurines with terminal alkynes: efficient access to functional dyes.

    Science.gov (United States)

    Wang, Shan; Hou, Ji-Ting; Feng, Mei-Lin; Zhang, Xiao-Zhuan; Chen, Shan-Yong; Yu, Xiao-Qi

    2016-02-14

    Alkenylation of unactivated arenes and 6-arylpurines with terminal alkynes in high yields using Cp*Co(CO)I2 as catalyst under mild conditions is described. This method shows outstanding functional group compatibility and can be applied in the design of a mitochondria-targeted imaging dye.

  9. Creating a Community of Inquiry in Online Library Instruction

    Science.gov (United States)

    Rapchak, Marcia E.

    2017-01-01

    According to the Community of Inquiry (CoI) model (Garrison, Anderson, & Archer, 2000), an enriching educational experience online in a collaborative learning environment requires three interdependent elements: social presence, teaching presence, and cognitive presence. Social presence provides interaction in the online environment that allows…

  10. Collaborative Communication in Work Based Learning Programs

    Science.gov (United States)

    Wagner, Stephen Allen

    2017-01-01

    This basic qualitative study, using interviews and document analysis, examined reflections from a Work Based Learning (WBL) program to understand how utilizing digital collaborative communication tools influence the educational experience. The Community of Inquiry (CoI) framework was used as a theoretical frame promoting the examination of the…

  11. EST Table: BY918733 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BY918733 E_ET_F1mg_23H04_F_0 10/09/28 52 %/192 aa gb|ACY09589.1| cytochrome oxidase subunit 1 [Tetracis cach...exiata] 10/08/29 55 %/154 aa FBpp0100176|mt:CoI-PA 10/08/28 42 %/149 aa MTCE.26#CE3

  12. EST Table: DC540689 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DC540689 E_FL_dpe-_07J11_F_0 10/09/28 54 %/184 aa gb|ACY09589.1| cytochrome oxidase subunit 1 [Tetracis cach...exiata] 10/09/02 49 %/180 aa FBpp0100176|mt:CoI-PA 10/08/28 42 %/149 aa MTCE.26#CE3

  13. American Society of Hand Therapists

    Science.gov (United States)

    ... ago RT @vicstar141 : #PROUD to launch the #handtherapy shop pilot @ChelwestFT today during #FabChangeWeek ! Improving availability of reh… https://t.co/iF8nnyjK7I — 1 day 11 hours ago #Job opportunity: Physical Therapist Outpatient - Agile Physical Therapy - Palo ...

  14. DNA barcoding of freshwater fishes and the development of a quantitative qPCR assay for the species-specific detection and quantification of fish larvae from plankton samples.

    Science.gov (United States)

    Loh, W K W; Bond, P; Ashton, K J; Roberts, D T; Tibbetts, I R

    2014-08-01

    The barcoding of mitochondrial cytochrome c oxidase subunit 1 (coI) gene was amplified and sequenced from 16 species of freshwater fishes found in Lake Wivenhoe (south-eastern Queensland, Australia) to support monitoring of reservoir fish populations, ecosystem function and water health. In this study, 630-650 bp sequences of the coI barcoding gene from 100 specimens representing 15 genera, 13 families and two subclasses of fishes allowed 14 of the 16 species to be identified and differentiated. The mean ± s.e. Kimura 2 parameter divergence within and between species was 0.52 ± 0.10 and 23.8 ± 2.20% respectively, indicating that barcodes can be used to discriminate most of the fish species accurately. The two terapontids, Amniataba percoides and Leiopotherapon unicolor, however, shared coI DNA sequences and could not be differentiated using this gene. A barcoding database was established and a qPCR assay was developed using coI sequences to identify and quantify proportional abundances of fish species in ichthyoplankton samples from Lake Wivenhoe. These methods provide a viable alternative to the time-consuming process of manually enumerating and identifying ichthyoplankton samples. © 2014 The Fisheries Society of the British Isles.

  15. Jakie są skutki finansowe i zdrowotne picia alkoholu? Przegląd literatury

    Directory of Open Access Journals (Sweden)

    Katarzyna Kolasa

    2015-09-01

    Discussion and conclusions: Alcohol consumption leads to the number of clinical and economic consequences. The available CoI studies provide valuable insight into which data source and methods are applicable to the calculation of alcohol impact on both mortality and costs.

  16. Home page of Hill Air Force Base

    Science.gov (United States)

    -777-1902 Military Flyovers Noise Hotline - FAQ Small Business Assistance Technical Data Requests Sun FrontRunner. @RideUTA bus ser... https://t.co/iWUrMPcZWX Facebook Logo In addition to the numerous world-class aerial acts and wide variety of static d... Facebook Logo Headed somewhere this #MemorialDay

  17. Designing Online Management Education Courses Using the Community of Inquiry Framework

    Science.gov (United States)

    Weyant, Lee E.

    2013-01-01

    Online learning has grown as a program delivery option for many colleges and programs of business. The Community of Inquiry (CoI) framework consisting of three interrelated elements--social presence, cognitive presence, and teaching presences--provides a model to guide business faculty in their online course design. The course design of an online…

  18. Learning Analytics for Communities of Inquiry

    Science.gov (United States)

    Kovanovic, Vitomir; Gaševic, Dragan; Hatala, Marek

    2014-01-01

    This paper describes doctoral research that focuses on the development of a learning analytics framework for inquiry-based digital learning. Building on the Community of Inquiry model (CoI)--a foundation commonly used in the research and practice of digital learning and teaching--this research builds on the existing body of knowledge in two…

  19. Exploring the Affordances of WeChat for Facilitating Teaching, Social and Cognitive Presence in Semi-Synchronous Language Exchange

    Science.gov (United States)

    Wang, Yuping; Fang, Wei-Chieh; Han, Julia; Chen, Nian-Shing

    2016-01-01

    This research is an exploratory study that evaluates the affordances of WeChat for the development of a community of inquiry (CoI) in semi-synchronous language exchange supported by WeChat. WeChat is an instant messenger that facilitates a multimodal environment in which interaction can happen synchronously, semi-synchronously and asynchronously…

  20. Action research in collaborative improvement

    NARCIS (Netherlands)

    Middel, H.G.A.; Coghlan, David; Brennan, Louis; McNichols, Tim

    2006-01-01

    There is an increasing need to apply and transfer continuous improvement (CI) to inter-organisational processes. As such collaborative improvement (CoI) is emerging as a new concept within managerial literature and practice. This paper begins with a discussion on the logic and value of applying

  1. The Predictive Relationship among the Community of Inquiry Framework, Perceived Learning and Online, and Graduate Students' Course Grades in Online Synchronous and Asynchronous Courses

    Science.gov (United States)

    Rockinson-Szapkiw, Amanda J.; Wendt, Jillian; Wighting, Mervyn; Nisbet, Deanna

    2016-01-01

    The Community of Inquiry framework has been widely supported by research to provide a model of online learning that informs the design and implementation of distance learning courses. However, the relationship between elements of the CoI framework and perceived learning warrants further examination as a predictive model for online graduate student…

  2. An Exploration of Interrelationships among Presence Indicators of a Community of Inquiry in a 3D Game-Like Environment for High School Programming Courses

    Science.gov (United States)

    Pellas, Nikolaos

    2017-01-01

    The combination of Open Sim and Scratch4OS can be a worthwhile innovation for introductory programming courses, using a Community of Inquiry (CoI) model as a theoretical instructional design framework. This empirical study had a threefold purpose to present: (a) an instructional design framework for the beneficial formalization of a virtual…

  3. MITIGASI PELINDIAN NITRAT PADA TANAH INCEPTISOL MELALUI PEMANFAATAN BAHAN NITRAT INHIBITOR ALAMI

    Directory of Open Access Journals (Sweden)

    Joko Pramono

    2012-05-01

    Full Text Available Mitigation of Nitrate Leaching in Inceptisol Soil Through the Use of Natural Nitrate Inhibitor ABSTRAK Pelindian NO3- merupakan salah satu mekanisme kehilangan N dalam aktivitas pertanian, yang dapat berdampak terhadap pencemaran lingkungan. Tujuan dari penelitian adalah untuk mengetahui penggunaan bahan alami sebagai nitrat inhibitor terhadap pelindian nitrat pada tanah Inceptisol. Pada penelitian ini diuji tiga jenis bahan nitrat inhibitor (NI alami yang berasal dari; serbuk biji Mimba (SBM, serbuk kulit kayu bakau (SKKB, dan serbuk daun kopi (SDK,yang dikombinasikan dengan tiga taraf dosis NI, yaitu: 20 %, 30 % dan 40 % dari urea yang diberikan, dan ditambah satu perlakuan kontrol tanpa NI. Bahan nitrat inhibitor diberikan bersama urea pada permukaan tanah dalam pot percobaan yang telah dibasahi dengan air suling. Hasil penelitian menunjukkan bahwa bahan NI yang berbeda memberikan respon terhadap penghambatan nitrifi kasi yang berbeda. Bahan NI yang berasal dari serbuk biji mimba memberikan tingkat penghambatan tertinggi sebesar (25,6 %, serbuk kulit kayu bakau sebesar (19,1 %, dan serbuk daun kopi sebesar 11,8 %. Bahan NI alami mampu menghambat nitrifi kasi melalui penghambatan pertumbuhan bakteri nitrifi kasi (pengoksida ammonium yang bersifat sementara pada kisaran 7-14 hari setelah aplikasi. Perlakuan berbagai bahan dan dosis NI mampu menekan pelindian nitrat rata-rata pada kisaran antara 56,6 sampai 62,8 % dan berbeda sangat nyata terhadap perlakuan kontrol tanpa NI. Bahan NI yang mampu menurunkan rata-rata pelindian nitrat pada pengamatan 14 hari setelah aplikasi tertinggi adalah SBM sebesar 74,15 %. Dosis optimal dua bahan NI terpilih yang menunjukkan kinerja penghambatan nitrifi kasi terbaik (SBM dan SKKB pada 7 hsa, masing-masing 18,30 % (R2 = 0,694 dan 21,67 % (R2=0.691 dari dosis urea yang diberikan. Kata kunci: Nitrifi kasi, nitrat inhibitor, pelindian nitrat ABSTRACT NO3 - leaching is one mechanism of N reduction in agricultural

  4. Pattern of postoperative pain management among adult surgical patients in a low-resource setting

    Directory of Open Access Journals (Sweden)

    Ogboli-Nwasor E

    2012-06-01

    Full Text Available Elizabeth Ogboli-Nwasor,1 Sa’adatu T Sule,2 Lazarus MD Yusufu31Department of Anaesthesia, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria; 2Department of Obstetrics and Gynaecology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria; 3Department of Surgery, Ahmadu Bello University Teaching Hospital, Zaria, NigeriaObjective: Postoperative pain is one of the most common complications of surgery. The pattern of management varies between centers. The current study aimed to study the prescription pattern and the common drugs used in the management of postoperative pain in adult surgical patients at Ahmadu Bello University Teaching Hospital (ABUTH; Zaria, Nigeria.Methods: Following ethical approval, a prospective observational study of consecutive adult patients who had surgery at the ABUTH Zaria was performed from January to December 2005. The data were entered into a proforma and analyzed using the Minitab statistical package.Results: One hundred and thirty-eight patients were included in the study. The age range was 17 to 80 years, with a mean age of 41 years. One hundred and thirty-two (95.7% of the prescriptions were written solely by the surgeon or surgical resident; passive suggestions were given by the anesthetists for only six patients (4.3%. Intermittent intramuscular injections of opioids/opiates were prescribed for 126 patients (91.3%, while nine patients (6.5% received intermittent intramuscular injections with non-steroidal anti-inflammatory drugs. Oral paracetamol was prescribed for six patients (4.3%, while three patients (2.1% received no postoperative analgesic. Moderate pain was recorded in 48 patients (34.8%, and 90 patients (65.2% had mild pain 8 hours after their operation before subsequent doses of analgesics were given. More females (81 patients [58.7%], than males (42 patients [29.7%] suffered moderate to severe pain. The reported side effects were nausea (reported by 32.6% of patients, dry mouth (21

  5. A suggested emergency medicine boot camp curriculum for medical students based on the mapping of Core Entrustable Professional Activities to Emergency Medicine Level 1 milestones

    Directory of Open Access Journals (Sweden)

    Lamba S

    2016-03-01

    Full Text Available Sangeeta Lamba, Bryan Wilson, Brenda Natal, Roxanne Nagurka, Michael Anana, Harsh Sule Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA Background: An increasing number of students rank Emergency Medicine (EM as a top specialty choice, requiring medical schools to provide adequate exposure to EM. The Core Entrustable Professional Activities (EPAs for Entering Residency by the Association of American Medical Colleges combined with the Milestone Project for EM residency training has attempted to standardize the undergraduate and graduate medical education goals. However, it remains unclear as to how the EPAs correlate to the milestones, and who owns the process of ensuring that an entering EM resident has competency at a certain minimum level. Recent trends establishing specialty-specific boot camps prepare students for residency and address the variability of skills of students coming from different medical schools. Objective: Our project’s goal was therefore to perform a needs assessment to inform the design of an EM boot camp curriculum. Toward this goal, we 1 mapped the core EPAs for graduating medical students to the EM residency Level 1 milestones in order to identify the possible gaps/needs and 2 conducted a pilot procedure workshop that was designed to address some of the identified gaps/needs in procedural skills. Methods: In order to inform the curriculum of an EM boot camp, we used a systematic approach to 1 identify gaps between the EPAs and EM milestones (Level 1 and 2 determine what essential and supplemental competencies/skills an incoming EM resident should ideally possess. We then piloted a 1-day, three-station advanced ABCs procedure workshop based on the identified needs. A pre-workshop test and survey assessed knowledge, preparedness, confidence, and perceived competence. A post-workshop survey evaluated the program, and a posttest combined with psychomotor skills test using three

  6. MODERN LANGUAGES AND DISTANCE EDUCATION: Thirteen Days in the Cloud

    Directory of Open Access Journals (Sweden)

    Elfe DONA

    2014-07-01

    Full Text Available This research study documents the journey of two modern language faculty (Spanish and German from their original beliefs that teaching foreign languages can only be conducted in a face-to-face format to their eventual development of an online class using Web 2.0 technologies to encourage their students’ active skills of reading and speaking in their target language. The research study shows how the instructors incorporated Web 2.0 technologies and used the Communities of Inquiry (CoI framework to design their online class to ensure their class had the essential elements of teaching presence, social presence and cognitive presence. Web 2.0 technologies used to build strong levels of CoI were BB-Collaborate web conferencing, Voki, VoiceThread, ANVILL, Fakebook, Bubble,us, Mindmapping, Flashcard Exchange, Glogster, Zunal, and Weebly.

  7. A double salt of iodobismuthate: cis-aquaiodidobis(1,10-phenanthrolinecobalt(II tris(1,10-phenanthrolinecobalt(II trans-hexa-μ2-iodido-hexaiodidotribismuthate(III

    Directory of Open Access Journals (Sweden)

    Jiongke Chen

    2011-09-01

    Full Text Available In the title complex, [Co(C12H8N23][CoI(C12H8N22(H2O][Bi3I12], conventionally abbreviated [Co(phen3][CoI(phen2(H2O][Bi3I12], where phen is 1,10-phenanthroline, the CoII atom in one cation is coordinated by six N atoms from three phen ligands in an octahedral coordination while the CoII atom in the other cation is coordinated octahedrally by four N atoms from two phen ligands, one water O atom and one I atom. In the anion, three BiIII ions adopt an octahedral coordination constructed by six I− ligands. The three BiI6 octahedra are fused together through trans face-sharing.

  8. Comparing communities of inquiry of Portuguese higher education students: one for all or one for each?

    Directory of Open Access Journals (Sweden)

    Jose António Moreira

    2013-05-01

    Full Text Available The purpose of this study was to report evidence obtained in a survey based on the Community of Inquiry (CoI framework (Garrison, Anderson & Archer, 1991; 2000 carried out in different groups. The study comprised 510 higher education students enrolled in blended online courses offered through Moodle platform during one semester. It considered students from different private and public Portuguese polytechnic schools and universities. Moreira & Almeida (2011 have suggested that CoI framework is a valid, reliable, and efficient measure of its dimensions within the Portuguese population. Although similarities in aspects of social presence were discovered among polytechnic and universities students, the two groups showed some differences. In particular, it was observed that the polytechnic students appear to be a more robust community when compared to university students.

  9. Testing the Model: A Phase 1/11 Randomized Double Blind Placebo Control Trial of Targeted Therapeutics: Liposomal Glutathione and Curcumin

    Science.gov (United States)

    2017-10-01

    Approach” Mariana Morris , PI, Nova Southeastern University; Role: Co-PI, Clinical Core PI DOD September 2014-September 2017 $190,000 Gulf War Illness...VAMC 5. Director, Miami VAMC Allergy Clinic, Tuesday MD clinic, and oversight of RN clinic and RN and ARNP clinic 6. Medical Director NSU Neuro Immune...Principal Investigator: Mariana Morris Role: Co-I laboratory studies of immune and genomics in the animal and human subjects, 20% effort Research

  10. Testing the Model: A Phase 1/2 Randomized Double Blind Placebo Control Trial of Targeted Therapeutics: Liposomal Glutathione and Curcumin

    Science.gov (United States)

    2016-10-01

    Understanding GWI: An Integrative Modelling Approach” Mariana Morris , PI, Nova Southeastern University; Role: Co-PI, Clinical Core PI DOD September...Medicine teaching attending, VAMC 5. Director, Miami VAMC Allergy Clinic, Tuesday MD clinic, and oversight of RN clinic and RN and ARNP clinic 6...Approach” Principal Investigator: Mariana Morris Role: Co-I laboratory studies of immune and genomics in the animal and human subjects, 20

  11. Characterization and Targeting of the Aldehyde Dehydrogenase Subpopulation in Ovarian Cancer

    Science.gov (United States)

    2013-07-01

    interactions R01 Role: Co-I (van Waardenburg ) Sponsor: NIH/NCI The DNA repair enzyme tyrosyl-DNA phosphodiesterase I as therapeutic target Major...ports the hypothesis that incessant ovulation is the culprit for tumor initi- ation. For example, women with poly- cystic ovarian syndrome , who by...nulliparous women, women with poly- cystic ovary syndrome , and women with other types of primary infertility who also have increased gonadotropin pro

  12. Brain Mechanisms of Affective Language Comprehension in Autism Spectrum Disorders

    Science.gov (United States)

    2016-10-01

    in effort or project goals. NICHD R01 Hippocampal- memory network development and episodic memory in early childhood Role: co-I; time committed...functional development of hippocampal- memory network in early childhood and its relation to episodic memory abilities. What other organizations were involved...1-0457 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Dr. Donald Joseph Bolger 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING

  13. Quiescent H-mode operation using torque from non-axisymmetric, non-resonant magnetic fields

    International Nuclear Information System (INIS)

    Burrell, K.H.; Garofalo, A.M.; Osborne, T.H.; Snyder, P.B.; Solomon, W.M.; Park, J.-K.; Fenstermacher, M.E.; Orlov, D.M.

    2013-01-01

    Quiescent H-mode (QH-mode) sustained by magnetic torque from non-axisymmetric magnetic fields is a promising operating mode for future burning plasmas including ITER. Using magnetic torque from n = 3 fields to replace counter-I p torque from neutral beam injection, we have achieved long duration, counter-rotating QH-mode operation with neutral beam injection (NBI) torque ranging continuously from counter-I p up to co-I p values of about 1 N m. This co-I p torque is about 3 times the scaled torque that ITER will have. This range also includes operation at zero net NBI torque, applicable to rf wave heated plasmas. These n = 3 fields have been created using coils either inside or, most recently, outside the toroidal coils. Experiments utilized an ITER-relevant lower single-null plasma shape and were done with ITER-relevant values ν ped * ∼0.08, β T ped ∼ 1%$ and β N = 2. Discharges have confinement quality H 98y2 = 1.3, exceeding the value required for ITER. Initial work with low q 95 = 3.4 QH-mode plasmas transiently reached fusion gain values of G = β N H 89 /q 95 2 =0.4, which is the desired value for ITER; the limits on G have not yet been established. This paper also includes the most recent results on QH-mode plasmas run without n = 3 fields and with co-I p NBI; these shots exhibit co-I p plasma rotation and require NBI torque ⩾2 N m. The QH-mode work to date has made significant contact with theory. The importance of edge rotational shear is consistent with peeling–ballooning mode theory. We have seen qualitative and quantitative agreement with the predicted torque from neoclassical toroidal viscosity. (paper)

  14. Quantifying the Electrocatalytic Turnover of Vitamin B12-Mediated Dehalogenation on Single Soft Nanoparticles.

    Science.gov (United States)

    Cheng, Wei; Compton, Richard G

    2016-02-12

    We report the electrocatalytic dehalogenation of trichloroethylene (TCE) by single soft nanoparticles in the form of Vitamin B12 -containing droplets. We quantify the turnover number of the catalytic reaction at the single soft nanoparticle level. The kinetic data shows that the binding of TCE with the electro-reduced vitamin in the Co(I) oxidation state is chemically reversible. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. On the Analytical Inversion of Lidar Returns from an Inhomogeneous Atmosphere.

    Science.gov (United States)

    1980-04-01

    of Clouds and Precipitation (Reidel, Dordrecht, Holand , 1978), pp. 20-21. 5. T. Okita, J. Ileteorol. Soc. Japan, 40, 39 (1962). 6. R. T. Brown, Jr...Cnt %ftl 44b cA Ln. 0Co I (a 0 0 0 i rJnc RANlIe (PER !Ora) F1 "Sure 9 Znversiooms obased Oen Eqs. (14), (16), and (23), with and vithoutIteration, fo

  16. A Surface Formulation for Characteristic Modes of Material Bodies

    Science.gov (United States)

    1974-10-01

    42 CHAPTER 3 4: CHARACTERISTIC MODES - A SURFACE FORMULATION 3.1 Theoretical Development The treatment of characteristic modes for perfectly...cgs* i + y mp ein•£ (A6 V; 1 TP At • CA6 I --- 4 1 o#i ajk(X MPcoeo* + umpsin# ) Iim n p-l1 Tp -Ax sin#i + Ay co* ] i (A-7) A4 APPWOIX II fill I vIal

  17. Burden of disease calculation, cost of illness analysis and demand ...

    African Journals Online (AJOL)

    The paper introduces the demand for death for Activities of Daily Living (ADL) measured disability as being pioneered by Igberaese and co-workers, as a way of eliminating the BoD and CoI once and for all. It makes DALY only equal to YLL, as YLD approaches zero. DALY will simply be the number of years of life lost due to ...

  18. Use Cases for Dynamic Secure Wireless Networking in Coalition Environments (Cas d utilisation de r seau sans fil dynamique et s curis dans des environnements de coalition)

    Science.gov (United States)

    2015-05-01

    Provider Willingness 15 and Degree of Exposure STO-TR-IST-109 v vi STO-TR-IST-109 List of Acronyms CC Coloured Cloud CoI Community of...could be applied to the MANET connectivity scenario. In PCN terminology [4]2, an E-node3 advertises guarantees of bandwidth and other services of...its Coloured Cloud4 (CC). It will be equipped with Service-Level Agreement (SLA) management functions, including support for security and risk. In

  19. International Symposium on Neurotoxins in Neurobiology (4th) Held in Bath, United Kingdom on 19th-23rd September 1993. Speakers’ Abstracts 1-25

    Science.gov (United States)

    1993-01-01

    experiments with plant materials following, in part, ethnopharmacological clues, has led to the discovery that several flavonoids have medium to high...1990), FEBS Letters, 270, 45-48. 27 0 AN HPLC ASSAY FOR THE NORDITERPENOID ALKALOID, METHYLLYCACONITINE P A Co , I S Blagbrough, B V L Potter, M G Rowan...Accordingly, we have developed a reverse phase HPLC assay for MLA for routine monitoring of alkaloid samples isolated from MLA-containing plant sources

  20. Tracking the Structural and Electronic Configurations of a Cobalt Proton Reduction Catalyst in Water

    Energy Technology Data Exchange (ETDEWEB)

    Moonshiram, Dooshaye; Gimbert-Suriñach, Carolina [Institute; Guda, Alexander [International; Picon, Antonio; Lehmann, C. Stefan; Zhang, Xiaoyi; Doumy, Gilles; March, Anne Marie; Benet-Buchholz, Jordi [Institute; Soldatov, Alexander [International; Llobet, Antoni [Institute; Departament; Southworth, Stephen H.

    2016-08-09

    Time resolved X-ray absorption spectroscopy (X-TAS) has been used to study the light induced hydrogen evolution reaction catalyzed by a highly stable cobalt complex, [Ru(bpy)3]2+ photosensitizer and an equimolar mixture of sodium ascorbate/ascorbic acid electron donor in pure water. XANES and EXAFS analysis of a binary mixture of the octahedral Co(III) pre-catalyst and [Ru(bpy)3]2+ after illumination, revealed in-situ formation of a square pyramidal Co(II) intermediate, with electron transfer kinetics of 51 ns. On the other hand, X-TAS experiments of the complete photocatalytic system in the presence of the electron donor showed the formation of a square planar Co(I) intermediate species within a few nanoseconds followed by its decay in the microsecond timescales. The Co(I) structural assignment is supported by calculations based on density functional theory (DFT). At longer reaction times, we observe the formation of the initial Co(III) species concomitant to the decay of Co(I), thus closing the catalytic cycle. The experimental X-ray absorption spectra of the molecular species formed along the catalytic cycle are modeled using a combination of molecular orbital DFT calculations (DFT-MO) and Finite Difference Method (FDM). These findings allowed us to unequivocally assign the full mechanistic pathway followed by the catalyst as well as to determine the rate limiting step of the process, which consists in the protonation of the Co(I). This study provides a complete kinetics scheme for the hydrogen evolution reaction by a cobalt catalyst, revealing unique information for the development of better catalysts for the reductive side of hydrogen fuel cells.

  1. Lymph-scintigraphic identification of sentinel lymph nodes in breast carcinoma and malignant melanoma patients

    International Nuclear Information System (INIS)

    Sergieva, S; Bajchev, G.; Aleksandrova, E.

    1999-01-01

    It is the purpose of the study to assay the possibilities of lymphoscintigraphy (LS) in evaluating local lymphatic drainage and sentinel lymph nodes (SLNs) location in patients presenting breast carcinoma and malignant melanoma. Twenty-nine women with breast carcinoma (TI-IIa clinical stage, age range 31 to 74 y) and 7 patients with malignant melanoma (Clark III-V) are scanned in the period 1997 through 1998. 99m Tc-sulphur colloid (Solco Lymphoscint, SORIN) with mean size of particles 50 nm is used. Planar images are obtained at 20 and 120-180 min after sc injection in the region of primary tumor, at mean radioactivity 20 MBq per injection site in a volume 0.2-0.3 ml. In the breast cancer patients Patent Blue V or Mitoxantrone is injected around the tumor twice - 20 and 3 to 1/2 hours prior to surgery. In malignant melanoma patients immunoscintigraphy using 740 MBq 99m Tc-anti-melanoma monoclonal antibodies (Technemab-K-1) is carried out before lymph node dissection. SLNs are visualized in 25 patients (86.2%) with breast cancer. In 21 (72%) patients to 4 SLNs are scanned in level I of the local axillary region, in 4 cases (14%) - in the region of axillary level II, in one female patient (3%) - at axillary level III, and in 3 patients (10%) i psilateral internal mammary lymph nodes are scanned. Two patients are suspected for the so-called s kip t ype of tumor lymphatic dissemination. In 4 patients no SLN images are visible. In breast carcinoma patients SLN are additionally stained blue and following intraoperative revision, evidence of metastatic involvement is established in 12 instances (41.3%). In 3 patients with melanoma in the abdomen and back SLNs are located in the region of inguinal and axillary lymph node groups, while in 3 patients presenting lesions to the surface of extremities only local lymph nodes draining the melanoma are visualized. Immunoscintigraphy shows enhanced uptake in the region of SLNs in 3 cases with the metastatic changes in them

  2. Early Outcomes of Sutureless Aortic Valves

    Directory of Open Access Journals (Sweden)

    Muhammet Onur Hanedan

    2016-06-01

    Full Text Available Background: In elderly high-risk surgical patients, sutureless aortic valve replacement (AVR should be an alternative to standard AVR. The potential advantages of sutureless aortic prostheses include reducing cross-clamping and cardiopulmonary bypass (CPB time and facilitating minimally invasive surgery and complex cardiac interventions, while maintaining satisfactory hemodynamic outcomes and low rates of paravalvular leakage. The current study reports our single-center experience regarding the early outcomes of sutureless aortic valve implantation. Methods: Between October 2012 and June 2015, 65 patients scheduled for surgical valve replacement with symptomatic aortic valve disease and New York Heart Association function of class II or higher were included to this study. Perceval S (Sorin Biomedica Cardio Srl, Sallugia, Italy and Edwards Intuity (Edwards Lifesciences, Irvine, CA, USA valves were used. Results: The mean age of the patients was 71.15±8.60 years. Forty-four patients (67.7% were female. The average preoperative left ventricular ejection fraction was 56.9±9.93. The CPB time was 96.51±41.27 minutes and the cross-clamping time was 60.85±27.08 minutes. The intubation time was 8.95±4.19 hours, and the intensive care unit and hospital stays were 2.89±1.42 days and 7.86±1.42 days, respectively. The mean quantity of drainage from chest tubes was 407.69±149.28 mL. The hospital mortality rate was 3.1%. A total of five patients (7.69% died during follow-up. The mean follow-up time was 687.24±24.76 days. The one-year survival rate was over 90%. Conclusion: In the last few years, several models of valvular sutureless bioprostheses have been developed. The present study evaluating the single-center early outcomes of sutureless aortic valve implantation presents the results of an innovative surgical technique, finding that it resulted in appropriate hemodynamic conditions with acceptable ischemic time.

  3. Early Outcomes of Sutureless Aortic Valves.

    Science.gov (United States)

    Hanedan, Muhammet Onur; Mataracı, İlker; Yürük, Mehmet Ali; Özer, Tanıl; Sayar, Ufuk; Arslan, Ali Kemal; Ziyrek, Uğur; Yücel, Murat

    2016-06-01

    In elderly high-risk surgical patients, sutureless aortic valve replacement (AVR) should be an alternative to standard AVR. The potential advantages of sutureless aortic prostheses include reducing cross-clamping and cardiopulmonary bypass (CPB) time and facilitating minimally invasive surgery and complex cardiac interventions, while maintaining satisfactory hemodynamic outcomes and low rates of paravalvular leakage. The current study reports our single-center experience regarding the early outcomes of sutureless aortic valve implantation. Between October 2012 and June 2015, 65 patients scheduled for surgical valve replacement with symptomatic aortic valve disease and New York Heart Association function of class II or higher were included to this study. Perceval S (Sorin Biomedica Cardio Srl, Sallugia, Italy) and Edwards Intuity (Edwards Lifesciences, Irvine, CA, USA) valves were used. The mean age of the patients was 71.15±8.60 years. Forty-four patients (67.7%) were female. The average preoperative left ventricular ejection fraction was 56.9±9.93. The CPB time was 96.51±41.27 minutes and the cross-clamping time was 60.85±27.08 minutes. The intubation time was 8.95±4.19 hours, and the intensive care unit and hospital stays were 2.89±1.42 days and 7.86±1.42 days, respectively. The mean quantity of drainage from chest tubes was 407.69±149.28 mL. The hospital mortality rate was 3.1%. A total of five patients (7.69%) died during follow-up. The mean follow-up time was 687.24±24.76 days. The one-year survival rate was over 90%. In the last few years, several models of valvular sutureless bioprostheses have been developed. The present study evaluating the single-center early outcomes of sutureless aortic valve implantation presents the results of an innovative surgical technique, finding that it resulted in appropriate hemodynamic conditions with acceptable ischemic time.

  4. The Freedom Solo pericardial stentless valve: Single-center experience, outcomes, and long-term durability.

    Science.gov (United States)

    Stanger, Olaf; Bleuel, Irina; Gisler, Fabian; Göber, Volkhard; Reineke, Sylvia; Gahl, Brigitta; Aymard, Thierry; Englberger, Lars; Carrel, Thierry; Tevaearai, Hendrik

    2015-07-01

    To report our institutional experience and long-term results with the Freedom Solo bovine pericardial stentless bioprosthesis (Sorin Group, Saluggia, Italy). Between January 2005 and November 2009, 149 patients (mean age, 73.6 ± 8.7 years; 68 [45.6%] female) underwent isolated (n = 75) or combined (n = 74) aortic valve replacement (AVR) using the Solo in our institution. Follow-up was 100% complete with an average follow-up time of 5.9 ± 2.6 years (maximum, 9.6 years) and a total of 885.3 patient years. Operative (30-day) mortality was 2.7% (1.3% for isolated AVR [n = 1] and 4.0% for combined procedures [n = 3]). All causes of death were not valve-related. Preoperative peak (mean) gradients of 74.2 ± 23.0 mm Hg (48.6 ± 16.3 mm Hg) decreased to 15.6 ± 5.4 mm Hg (8.8 ± 3.0 mm Hg) after AVR, and remained low for up to 9 years. The postoperative effective orifice area was 1.6 ± 0.57 cm(2), 1.90 ± 0.45 cm(2), 2.12 ± 0.48 cm(2), and 2.20 ± 0.66 cm(2) for the valve sizes 21, 23, 25, and 27, respectively, with absence of severe prosthesis-patient mismatch and 0.7% (n = 1) experienced moderate prosthesis-patient mismatch. During follow-up, 26 patients experienced structural valve deterioration (SVD) and 14 patients underwent explantation. Kaplan-Meier estimates for freedom from death, explantation, and SVD at 9 years averaged 0.57 (range, 0.47-0.66), 0.82 (range, 0.69-0.90), and 0.70 (range, 0.57-0.79), respectively. The Freedom Solo stentless aortic valve is safe to implant and shows excellent early and midterm hemodynamic performance. However, SVD was observed in a substantial number of patients after only 5-6 years and the need for explantation increased markedly, suggesting low durability. Copyright © 2015 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

  5. 25-hydroxy-Vitamin D status: limitations in comparison and clinical interpretation of serum-levels across different assay methods.

    Science.gov (United States)

    Enko, Dietmar; Fridrich, Leo; Rezanka, Erwin; Stolba, Robert; Ernst, Juliane; Wendler, Iris; Fabian, Daniel; Hauptlorenz, Susanne; Halwachs-Baumann, Gabriele

    2014-01-01

    Background: Over the last decade, clinical interest to evaluate human 25-hydroxy-vitamin D (25[OH]D) serum levels has increased exponentially. In the present study, four chemiluminescence immunoassays (CLIA), one radioimmunoassy (RIA), and one high performance liquid chromatography (HPLC) method were compared and also with the liquid chromatography-tandem mass spectrometry (LC-MS/MS) method in view of 25(OH)D serum level determination. Methods: For the method comparison, blood samples from 133 consecutive patients were prospectively collected. All participants gave written informed consent for their blood samples to be used in this study. They came to the Department of Nuclear Medicine of the Central Hospital Steyr (Austria) for osteodensidometric measurement as part of their preventive medical check-up. Pearson's correlation coefficients, Bland-Altman plots, and paired t-tests were calculated. Assay-specific reference ranges were considered using blood samples from persons with normal parathormone, calcium, and total-protein values (n = 97). Results: The highest correlation was between the HPLC and the LC-MS/MS method (r = 0.96). The lowest correlation was between the cobas Vitamin D3 assay (Roche) and any of the evaluated assays (r = 0.46 - 0.63). Bland-Altman plots revealed a big negative mean bias in three assays (cobas Vitamin D3 assay [Roche]: -22.8; DiaSorin LIAISON [25[OH]D total CLIA [Diasorin]: -18.4; Diasorin 25[OH]D125 I RIA [Diasorin]: -23.8 [nmol/L]) and a much smaller positive mean bias in the other assays (ClinRep complete 25[OH]D2/D3 HPLC kit [Recipe]: 2.7; ADVIA Centaur Vitamin D total assay [Siemens]: 8.2; IDS total vitamin D assay [Immunodiagnostic Systems]: 12.1 [nmol/L]) compared to the LC-MS/MS method. Meanwhile, the manufacturer has withdrawn the cobas Vitamin D3 assay from the market. Conclusions: Poor antibody specificity with cross-reactivity to other vitamin D metabolites, incomplete extraction of the 25(OH)D analyte from the vitamin D

  6. Methodological issues in assessing plasma 25-hydroxyvitamin D concentration in newborn infants.

    Science.gov (United States)

    Gallo, Sina; Comeau, Kathryn; Agellon, Sherry; Vanstone, Catherine; Sharma, Atul; Jones, Glenville; L'abbé, Mary; Khamessan, Ali; Weiler, Hope; Rodd, Celia

    2014-04-01

    Although no gold standard exists, liquid chromatography tandem mass spectrometry (LC-MS/MS) is a precise and accurate method for the analysis of plasma 25-hydroxyvitamin D (25(OH)D). Immunoassays are more readily available and require small volume sampling, ideal for infant testing. The objective was to compare two commercially available immunoassays for measuring circulating 25(OH)D concentration in infant plasma against LC-MS/MS. Capillary blood samples from 103 infants were analyzed for plasma 25(OH)D using an enzyme immunoassay (EIA, Octeia, IDS Ltd.) and radioimmunoassay (RIA, DiaSorin). Plasma 25(OH)D(3), C-3 epimer of 25(OH)D(3) (3-epi-25(OH)D(3)) and 24,25-dihydroxyvitamin D (24,25(OH)(2)D(3)) were measured on the same samples using LC-MS/MS. To establish whether plasma 24,25(OH)(2)D(3) or 3-epi-25(OH)D(3) interferes with these immunoassay results, the zero 25(OH)D calibrator from each assay kit was spiked with increasing amounts of 24,25(OH)(2)D(3) or 3-epi-25(OH)D(3). Classifying infants below the common vitamin D status targets of 50 nmol/L and 75 nmol/L respectively, 58% and 99% fell below using the RIA, 19% and 56% with the EIA and 31% and 76% with LC-MS/MS. Compared to LC-MS/MS, both immunoassays showed poor Bland-Altman limits of agreement for 25(OH)D concentrations (RIA: limits of agreement -27 to +13%; EIA: -12 to +41%), and mountain plots (folded cumulative distribution) depicted significant skew and bias. Spiked 24,25(OH)2D3 concentrations, but not 3-epi-25(OH)D3, appeared as >100% of known values on the EIA but not on the RIA thus, suggesting that the EIA may cross-react with 24,25(OH)(2)D(3) to a greater extent than 3-epi-25(OH)D(3). Two common immunoassays resulted in very different classifications of vitamin D status possibly related to the interference of other vitamin D metabolites. Based on these data, LC-MS/MS assessment of vitamin D status is recommended in young infants (4-6 weeks of age). Copyright © 2014 Elsevier Inc. All rights

  7. Differential extraction of endogenous and exogenous 25-OH-vitamin D from serum makes the accurate quantification in liquid chromatography-tandem mass spectrometry assays challenging.

    Science.gov (United States)

    Lankes, Ulrich; Elder, Peter A; Lewis, John G; George, Peter

    2015-01-01

    Extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis is the method of choice when it comes to the accurate quantification of 25-OH-vitamin D in blood samples. It is generally assumed that the addition of exogenous internal standard allows for the determination of the endogenous analyte concentration. In this study we investigated the extraction properties of endogenous and exogenous 25-OH-vitamin D. Eight samples were used for the evaluation of the extraction procedure and 59 patients' samples for a method comparison. The methanol-to-sample ratio (v/v) and the sample-to-hexane ratio (v/v) were varied and the LC-MS/MS signals of endogenous 25-OH-vitamin D3, spiked 25-OH-vitamin D2 and internal standard of the extracts recorded. The optimized 'in-house' LC-MS/MS assay was compared to two automated chemiluminescence immunoassays from DiaSorin and Abbott. Mathematical analysis of the data revealed a differential extraction of endogenous 25-OH-vitamin D3, spiked 25-OH-vitamin D2 and non-equilibrated internal standard. Exogenous 25-OH-vitamin D can be measured accurately if a definite methanol-to-sample ratio is used. Endogenous 25-OH-vitamin D is affected by critical quantification issues due to a differential slope in the extraction profile. The actual 25-OH-vitamin D concentration can be one-third above the measured extractable concentration. Results confirm that the 'in-house' LC-MS/MS assay provides reproducible 25-OH-vitamin D results. Discordant concentrations of 25-OH-vitamin D from LC-MS/MS assays can be caused by selection of suboptimal extraction conditions. Furthermore, a different sample pretreatment or solvent extraction system may result in a different dissociation and extraction yield of endogenous 25-OH-vitamin D and therefore contribute to variations of LC-MS/MS results. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  8. Aortic valve replacement with sutureless prosthesis: better than root enlargement to avoid patient-prosthesis mismatch?

    Science.gov (United States)

    Beckmann, Erik; Martens, Andreas; Alhadi, Firas; Hoeffler, Klaus; Umminger, Julia; Kaufeld, Tim; Sarikouch, Samir; Koigeldiev, Nurbol; Cebotari, Serghei; Schmitto, Jan Dieter; Haverich, Axel; Shrestha, Malakh

    2016-06-01

    Aortic valve replacement in patients with a small aortic annulus may result in patient-prosthesis mismatch (PPM). Aortic root enlargement (ARE) can reduce PPM, but leads to extended cardiac ischaemia times. Sutureless valves have the potential to prevent PPM while reducing cardiac ischaemia times. Between January 2007 and December 2011, a total of 128 patients with a small aortic annulus underwent surgery for aortic valve stenosis at our centre. Thirty-six (17% male, n = 6) patients received conventional valve replacement with ARE and 92 (16% male, n = 18) subjects received sutureless valve implantation (Sorin Perceval). We conducted a comparative, retrospective study with follow-up. The sutureless group showed a significantly higher age (79 years) than the ARE patients (62 years, P body surface area was 0.91 ± 0.2 cm(2)/m(2) in ARE patients and 0.83 ± 0.14 cm(2)/m(2) in sutureless patients (P = 0.040). The rate of patients with severe PPM was 6% (n = 2) in ARE patients and 11% (n = 8%) in sutureless patients (not significant, n.s.). The 30-day mortality rates were 2% (n = 2) in sutureless patients and 6% (n = 2) in ARE patients (n.s.). The 1- and 5-year survival rates of the sutureless group were 92 and 54% years, respectively, whereas the 1- and 5-year survival rates of the ARE group were 76% (n.s.). Although the sutureless valve patients received significantly more concomitant procedures, all operation-associated times were significantly shorter. Despite sutureless valve patients being older, the 30-day mortality and survival rates were comparable in the two groups. Since the indexed EOA was only slightly lower and the incidence of severe PPM was not significantly higher in the sutureless valve patients, we conclude that sutureless valve implantation is an alternative to conventional ARE to treat a small aortic annulus and avoid PPM, especially in geriatric patients who benefit from the quick implantation process. © The Author 2016. Published by Oxford

  9. "E-tivities from the Front Line”: A Community of Inquiry Case Study Analysis of Educators’ Blog Posts on the Topic of Designing and Delivering Online Learning

    Directory of Open Access Journals (Sweden)

    Phemie Wright

    2014-04-01

    Full Text Available Designing and implementing successful online learning has been at the forefront of institutional agendas since digital learning increased in market demand over the last decade. However there is still ongoing debate as to the “how” of this arduous task. The Community of Inquiry (CoI is one learning design method that has seen potential in the field, but practical implementation of designing for the important components of Social, Cognitive and Teaching Presence have yet to be fully realised. This paper researches an e-learning design strategy called E-tivities as a suggested possible method for designing for CoI components. The research explored recent online blog posts of experienced learning designers’ and educators’ experience in designing successful online learning using E-tivities. Results suggest the E-tivities do have the potential to cater for all Presences of CoI. Specifically when using E-tivities to design online learning Affective Expression was the highest reported Social Presence design factor. All four components of Cognitive Presence appeared to be present in E-tivities design. The most important component for adequate Teaching Presence factors was the initial Design and Organisation of the course. E-tivities and the 5-Stage Model provides a solid framework for this to occur.

  10. Regio- and stereo-selective polymerization of 1,3-butadiene catalyzed by phosphorus–nitrogen PN3-pincer cobalt(ii) complexes

    KAUST Repository

    Gong, Dirong

    2016-11-11

    A new family of cobalt complexes (CoCl2-H, CoCl2-Me, CoCl2-iPr, CoBr2-H, CoBr2-Me, CoBr2-iPr, CoI2-H, CoI2-Me, and CoI2-iPr) supported by a PN3 ligand (6-(N,N′-di-t-butylphosphino)-2-pyrazol-yl-aminopyridine) have been prepared and fully characterized by FT-IR, elemental analysis, and X-ray analysis. The X-ray analysis reveals a trigonal bipyramidal conformation in the solid state for all representative complexes, CoCl2-H, CoBr2-H, CoBr2-iPr and CoI2-Me. The cobalt center is chelated by the PN3 ligand through the pyridinyl nitrogen, the pyrazol nitrogen and the phosphorus donor, with a long Co-P bond distance indicating a labile character. On activation with AlEt2Cl, Al2Et3Cl3, MAO, [Ph3C]+[B(C6F5)4]-/AliBu3 or AliBu3, cis-1,4 selective butadiene polymerization was achieved with up to 98.6% selectivity. The polymerization results show that the cis-1,4 selectivity is influenced by the steric hindrance, increasing with the bulkiness of the substituent groups (CoX2-iPr > CoX2-Me > CoX2-H) at the 3,5-positions of the pyrazole moiety, together with a slight decrease in activity. The activity changes in the order CoCl2L ≈ CoBr2L > CoI2L (for the same ligand L) when MAO is used as the activator, while the high level of cis-1,4 selectivity is maintained. It is possible to switch the selectivity from cis-1,4 to syndiotactic-1,2 by adding PPh3 © The Royal Society of Chemistry.

  11. Reactor-relevant quiescent H-mode operation using torque from non-axisymmetric, non-resonant magnetic fields

    International Nuclear Information System (INIS)

    Burrell, K. H.; Garofalo, A. M; Osborne, T. H.; Schaffer, M. J.; Snyder, P. B.; Solomon, W. M.; Park, J.-K.; Fenstermacher, M. E.

    2012-01-01

    Results from recent experiments demonstrate that quiescent H-mode (QH-mode) sustained by magnetic torque from non-axisymmetric magnetic fields is a promising operating mode for future burning plasmas. Using magnetic torque from n=3 fields to replace counter-I p torque from neutral beam injection (NBI), we have achieved long duration, counter-rotating QH-mode operation with NBI torque ranging from counter-I p to up to co-I p values of 1-1.3 Nm. This co-I p torque is 3 to 4 times the scaled torque that ITER will have. These experiments utilized an ITER-relevant lower single-null plasma shape and were done with ITER-relevant values of ν ped * and β N ped . These discharges exhibited confinement quality H 98y2 =1.3, in the range required for ITER. In preliminary experiments using n=3 fields only from a coil outside the toroidal coil, QH-mode plasmas with low q 95 =3.4 have reached fusion gain values of G=β N H 89 /q 95 2 =0.4, which is the desired value for ITER. Shots with the same coil configuration also operated with net zero NBI torque. The limits on G and co-I p torque have not yet been established for this coil configuration. QH-mode work to has made significant contact with theory. The importance of edge rotational shear is consistent with peeling-ballooning mode theory. Qualitative and quantitative agreements with the predicted neoclassical toroidal viscosity torque is seen.

  12. Medical Community of Inquiry: A Diagnostic Tool for Learning, Assessment, and Research

    Directory of Open Access Journals (Sweden)

    Rakefet Ackerman

    2017-01-01

    Full Text Available Aim/Purpose: These days educators are expected to integrate technological tools into classes. Although they acquire relevant skills, they are often reluctant to use these tools. Background:\tWe incorporated online forums for generating a Community of Inquiry (CoI in a faculty development program. Extending the Technology, Pedagogy, and Content Knowledge (TPACK model with Assessment Knowledge and content analysis of forum discourse and reflection after each CoI, we offer the Diagnostic Tool for Learning, Assessment, and Research (DTLAR. Methodology: This study spanned over two cycles of a development program for medical faculty. Contribution: This study demonstrates how the DTLAR supports in-depth examination of the benefits and challenges of using CoIs for learning and teaching. Findings: Before the program, participants had little experience with, and were reluctant to use, CoIs in classes. At the program completion, many were willing to adopt CoIs and appreciated this method’s contribution. Both CoIs discourse and reflections included positive attitudes regarding cognitive and teacher awareness categories. However, negative attitudes regarding affective aspects and time-consuming aspects of CoIs were exposed. Participants who experienced facilitating a CoI gained additional insights into its usefulness. Recommendations for Practitioners\t: The DTLAR allows analyzing adaption of online forums for learning and teaching. Recommendation for Researchers: The DTLAR allows analyzing factors that affect the acceptance of online fo-rums for learning and teaching. Impact on Society\t: While the tool was implemented in the context of medical education, it can be readily applied in other adult learning programs. Future Research: The study includes several design aspects that probably affected the improve-ment and challenges we found. Future research is called for providing guidelines for identifying boundary conditions and potential for further

  13. Journal bias or author bias?

    Science.gov (United States)

    Harris, Ian

    2016-01-01

    I read with interest the comment by Mark Wilson in the Indian Journal of Medical Ethics regarding bias and conflicts of interest in medical journals. Wilson targets one journal (the New England Journal of Medicine: NEJM) and one particular "scandal" to make his point that journals' decisions on publication are biased by commercial conflicts of interest (CoIs). It is interesting that he chooses the NEJM which, by his own admission, had one of the strictest CoI policies and had published widely on this topic. The feeling is that if the NEJM can be guilty, they can all be guilty.

  14. National Dam Safety Program. Alder Pond Dam (Inventory Number N.Y. 1489), Black River Basin, Oneida County, New York. Phase I Inspection Report,

    Science.gov (United States)

    1981-06-17

    CAMAL )57 7) Maximum K~nown Flood 8) At Time of Inspection______ 93-15-4( 9/8C) AL R Po4 PAPA CREST: (CLAT IE) ELEVATION: .7 Type: -AQI H 5 a Width...T - L jR iT BLACK RNE. CAmAL --- Io 1500 A .T- PRO F ILE. T-OP EABA"MEIPT (CANAL) --ECT -14 A-A to/8O 100 I-.U 2O 11 0. 7 22I- co I.)-- LII___ ___ __1

  15. Hawaii Energy and Environmental Technologies (HEET) Initiative

    Science.gov (United States)

    2009-05-01

    CM CO CO CO CO (O CM •* CM •^J- COCO CO CO T-«M*O^IO«D r- co en OrNn^lOIONCO CD c: r O o N -^ C T> 0 f- -*-> n u o (U CO I...The fiberoptic probe consists of seven 200 urn core UV silica fibers encased within a 3.2 mm (0.125 inch) o.d. stainless steel sleeve. The center... fiber brings radiation from the laser into the cell, while the six surrounding fibers are used to collect the Raman-shifted light and transmit it to

  16. Cardiac Output and Performance during a Marathon Race in Middle-Aged Recreational Runners

    OpenAIRE

    Billat, Véronique L.; Petot, Hélène; Landrain, Morgan; Meilland, Renaud; Koralsztein, Jean Pierre; Mille-Hamard, Laurence

    2012-01-01

    Purpose. Despite the increasing popularity of marathon running, there are no data on the responses of stroke volume (SV) and cardiac output (CO) to exercise in this context. We sought to establish whether marathon performance is associated with the ability to sustain high fractional use of maximal SV and CO (i.e, cardiac endurance) and/or CO, per meter (i.e., cardiac cost). Methods. We measured the SV, heart rate (HR), CO, and running speed of 14 recreational runners in an incremental, maxima...

  17. The complex nature of phthalocyanine/gold interfaces

    International Nuclear Information System (INIS)

    Lindner, Susi; Treske, Uwe; Knupfer, Martin

    2013-01-01

    We compare the electronic properties of the interface between Au(1 0 0) and cobalt phthalocyanine (CoPc), fluorinated F 16 CoPc as well as CuPc using X-ray photoemission spectroscopy and valence band ultra-violet photoemission spectroscopy. Our results show that in addition to the formation of an interface dipole at the interfaces of CoPc and F 16 CoPc to gold, there is a local charge transfer to the central Co ion, which as a result is reduced to Co(I).

  18. Study of X-ray spectrum of laser-produced gold plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Busquet, M. (CEA Centre d' Etudes de Limeil, 94 - Villeneuve-Saint-Georges (France)); Pain, D.; Bauche, J.; Luc-Koenig, E. (Centre National de la Recherche Scientifique, 91 - Orsay (France). Lab. Aime Cotton)

    1985-02-01

    Aiming at the spectroscopic diagnostic of gold plasmas, we have studied the wavelengths and intensities of X-ray spectral lines emitted in the range 4.4 to 6.2 angstroms by a target made of gold alloyed to a few percent of aluminium irradiated by a laser pulse. Aluminium yields the wavelength calibration and a monitoring of the temperature and the density of the plasma. The main features of the gold spectrum in this spectral range are due to the 3d-4f, 3p-4s and 3d-4p transitions of gold in the Co I through Cu I isoelectronic sequences.

  19. Study of X-ray spectrum of laser-produced gold plasmas

    International Nuclear Information System (INIS)

    Busquet, M.; Pain, D.; Bauche, J.; Luc-Koenig, E.

    1985-01-01

    Aiming at the spectroscopic diagnostic of gold plasmas, we have studied the wavelengths and intensities of X-ray spectral lines emitted in the range 4.4 to 6.2 angstroms by a target made of gold alloyed to a few percent of aluminium irradiated by a laser pulse. Aluminium yields the wavelength calibration and a monitoring of the temperature and the density of the plasma. The main features of the gold spectrum in this spectral range are due to the 3d-4f, 3p-4s and 3d-4p transitions of gold in the Co I through Cu I isoelectronic sequences. (orig.)

  20. Coordination compounds of cobalt and cadmium with isobutyric acid amide

    International Nuclear Information System (INIS)

    Tsivadze, A.Yu.; Ivanova, I.S.; Solovkina, O.A.

    1983-01-01

    Coordination compounds of cobalt and cadmium with isobutyric acid amide (IBAA) of Co(NCS) 2 x(IBAA) 2 (H 2 O) 2 , CoCl 2 (IBAA) 4 , CoI 2 (IBAA) 8 (H 2 O) 2 , CdI 2 (IBAA) 2 composition have been synthesized and characterized. Their infrared absorption spectra (200-400 cm -1 ), electron reflection spectra (200-750 nm) were studied. It is shown that in all compounds there are IBAA molecUles coordinated through an oxygen atom. Thiocyanogroups are coordinated throUgh nitrogen atoms

  1. ANTIOXIDANT AN O ANTIMICROBIAL ACTIVITY OF TANNINS OF OENOTHERA ROSEA L 'HÉR. EX A/TON

    OpenAIRE

    Kasay, M. I.; Huamán, J.; Woolcott, J.

    2014-01-01

    The objective of this research was to determine the antioxidant activity of alcoholic and aqueous extracts of the Oenothera rosea L "Hér. Ex Aiton by using the DPPH method getting as an inhibitory concentration far leaves in ethanol extrae!(IC50) 34,99 µg/ml. We also performed the antimicrobial activity assay which yielded an antibacterial response against Escherichia co/ i, but not against Sa/monel/a gal/inarun, far all concentrations of the aqueous and ethanol extracts. El objetivo ...

  2. Snohomish Estuary Wetlands Study Volume III. Classification and Mapping

    Science.gov (United States)

    1978-07-01

    Marine plant communities form the basis for some of the most complex i food webs known to man. Because of their complexity any destruction of these plant... NCV ) Ř fv;1 4 CV r% . coI * ".444 Ř m- 0mf n4 ~ ’ oC- . -4c C4 C CJL t o% P o I-""C4enc n S qw qt "* *n *nL P o% 0zwk oU a "C-4 2 C" Iv3gMNIV~ I.z -I

  3. Economic context analysis in mental health care. Usability of health financing and cost of illness studies for international comparisons.

    Science.gov (United States)

    Salvador-Carulla, L; Hernández-Peña, P

    2011-03-01

    This paper discusses an integrated approach to mental health studies on Financing of Illness (FoI) and health accounting, Cost of Illness (CoI) and Burden of Disease (BoD). In order to expand the mental health policies, the following are suggested: (a) an international consensus on the standard scope, methods to collect and to analyse mental health data, as well as to report comparative information; (b) mathematical models are also to be validated and tested in an integrated approach, (c) a better knowledge transfer between clinicians and knowledge engineers, and between researchers and policy makers to translate economic analysis into practice and health planning.

  4. All 25-hydroxyvitamin D-deficient Indian postmenopausal women do not have secondary hyperparathyroidism.

    Science.gov (United States)

    Dixit, Vivek; Tripathi, R L; Dhanwal, Dinesh Kumar

    2018-05-27

    This study shows a high 25-hydroxyvitamin D deficiency among postmenopausal women accompanying secondary hyperparathyroidism. However, a sizable number of subjects did not have secondary hyperparathyroidism despite having low 25-hydroxyvitamin D levels. This condition arises a research question in clinical practice needed to be addressed in the future. The present study was attempted to determine the prevalence of secondary hyperparathyroidism and also to analyze the mean value (cutoff) of 25-hydroxyvitamin D from where the PTH begins to rise in Indian postmenopausal women. A cross-sectional study including 334 postmenopausal women attending the outpatient department (MOPD) of Lok Nayak Hospital, New Delhi, between July 2008 and June 2010. Institutional ethical approval was obtained for this study. The apparently healthy postmenopausal women and attendees of the patients were included in the study. Post-thyroidectomy, thyroid illness, pregnant women, subjects taking drugs that can affect bone mineral metabolism, such as glucocorticoids, antitubercular therapy, antiepileptic, and 25-hydroxyvitamin D supplement were excluded from the study. BMD parameters such as PTH and 25(OH)D were measured by using commercial kits from DiaSorin, USA, and blood chemistry was evaluated by standard methods from the central facility of the center. Dietary calcium was analyzed by applying a food frequency questionnaire by a trained dietician. Mean (SD) age of the subjects was 56.4 ± 7.7 years. The mean BMI was 24.7 ± 5.5 kg/m 2 . The baseline biochemical investigations such as total bilirubin, liver function test (LFT), kidney function test (KFT), calcium, phosphorous, total protein, and serum albumin were in reference range except alkaline phosphatase (ALP). The mean values of 25(OH)D and PTH were 12.95 ± 8.08 ng/ml and 91.60 ± 75.56 pg/ml respectively. The 24-h dietary calcium intake was 487.06 ± 239.36 mg/24 h. 25-hydroxyvitamin D deficiency was found

  5. EDUCATION MANAGEMENT DECISION-MAKERS IN EUROPEAN PRE – UNIVERSITY EDUCATION

    Directory of Open Access Journals (Sweden)

    DUMITRAȘCU DANUȚ DUMITRU

    2012-12-01

    Full Text Available EDUCATION MANAGEMENT DECISION-MAKERS IN EUROPEAN PRE – UNIVERSITY EDUCATION Ana Tuºa, 1 Affiliation , “Lucian Blaga” University of Sibiu, Faculty of Economics, Department of management Claudiu Sorin Voinia 2 , Affiliation, “Lucian Blaga” University of Sibiu Faculty of Engineering, Department of Industrial Engineering Dãnuþ Dumitru Dumitraºcu 3 Affiliation, “Lucian Blaga” University of Sibiu, Faculty of Economics, Department of management The theme paper consists in a comparative analysis of European preuniveristary education decision makers. Decision makers in preuniversity education management remain the key issue in the political agenda of most European countries. The diversity of educational policies in each European country aims to increase school autonomy, in a way that allows comparison of their main elements of management. Scientific research carried out aimed both theoretical and practical terms: - comparative analysis of how the makers of European schools are responsible for the management practiced in the educational institution. - identification of the achievement of school autonomy. Lately, in terms of policy makers and school autonomy, schools have gone through many reforms. It was felt the need to improve the democratic management and the quality of the educational process. The analysis and the approaches differ in terms of pace of reform, scale transfer of authority and areas that apply. No approach can be chosen as the ideal one or more effective than others, because the contexts in which they were made are so diverse. However, as it moves along, educational policy makers can learn from the approaches and experiences of others. The methodology was based on: the study of scientific literature from the country and abroad, on the theory and practice regarding the decision in the management of school education activities. Comparative analysis was conducted based on questionnaires

  6. A novel Haemosporida clade at the rank of genus in North American cranes (Aves: Gruiformes).

    Science.gov (United States)

    Bertram, Miranda R; Hamer, Sarah A; Hartup, Barry K; Snowden, Karen F; Medeiros, Matthew C; Outlaw, Diana C; Hamer, Gabriel L

    2017-04-01

    The unicellular blood parasites in the order Haemosporida are highly diverse, infect many vertebrates, are responsible for a large disease burden among humans and animals, and have reemerged as an important model system to understand the evolutionary and ecological dynamics of host-parasite interactions. The phylogenetics and systematics of Haemosporida are limited by poor sampling of different vertebrate host taxa. We surveyed the Haemosporida of wild whooping cranes (Grus americana) and sandhill cranes (Grus canadensis) (Aves: Gruiformes) using a combination of morphological and molecular approaches. We identified Haemoproteus antigonis in blood smears based on published morphological descriptions. Phylogenetic analysis based on partial cytochrome b (cytb) and cytochrome oxidase (coI) sequences placed H. antigonis parasites in a novel clade, distinct from all avian Haemosporida genera for which cytb and/or coI sequences are available. Molecular clock and divergence estimates suggest this crane clade may represent a new genus. This is the first molecular description of H. antigonis and the first report of H. antigonis in wild whooping cranes, an endangered bird in North America. Further sampling of Haemosporida, especially from hosts of the Gruiformes and other poorly sampled orders, will help to resolve the relationship of the H. antigonis clade to other avian Haemosporida genera. Our study highlights the potential of sampling neglected host species to discover novel lineages of diverse parasite groups. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  7. How easy is CO2 fixation by M-C bond containing complexes (M = Cu, Ni, Co, Rh, Ir)?

    KAUST Repository

    Nolan, Steve; Cavallo, Luigi; Poater, Albert; Vummaleti, Sai V. C.; Talarico, Giovanni

    2015-01-01

    A comparison between different M–C bonds (M = Cu(I), Ni(II), Co(I), Rh(I) and Ir(I)) has been reported by using density functional theory (DFT) calculations to explore the role of the metal in the fixation or incorporation of CO2 into such complexes. The systems investigated are various metal based congeners of the Ir-complex 8 [(cod)(IiPr)Ir-CCPh], with a ligand scaffold based on cod and IiPr ligands (cod = 1,5-cyclooctadiene; IiPr = 1,3-bis(isopropyl)imidazol-2-ylidene). The results of this study show that the calculated CO2 insertion barriers follow the trend: Cu(I) (20.8 kcal mol−1) < Rh(I) (30.0 kcal mol−1) < Co(I) (31.3 kcal mol−1) < Ir(I) (37.5 kcal mol−1) < Ni(II) (45.4 kcal mol−1), indicating that the Cu(I) based analogue is the best CO2 fixer, while Ni(II) is the worst in the studied series.

  8. Students' perceptions on IWB through the lens of the community of inquiry framework

    Directory of Open Access Journals (Sweden)

    Molly Patricia van Niekerk

    2015-11-01

    Full Text Available Interactive whiteboards (IWBs are being utilised at a rapidly increasing rate, especially in distance education (DE. As a medium of instruction they allow the presenter to simultaneously interact with numerous students at different centres across the country. This study is unique in the sense that a collaborative learning community is created between two groups separated by distance. If utilised correctly and efficiently, IWBs have the potential to enhance the teaching and learning experience for the student. This article focuses on the perceptions of students (adult learners from various school management teams (SMT, pertaining to their experiences with several IWB sessions. Open-ended questionnaires were completed by 45 students enrolled for the Advanced Certificate in Education (School Management and Leadership (ACE SL. Participants' perceptions with regard to their IWB learning experience were determined according to the Community of Inquiry (CoI framework, creating a collaborative constructivist educational experience. This article will indicate how important it is to focus on keeping the balance between the three presences in the CoI and also highlight the crucial role that presenters play to ensure an effective teaching and learning experience through the use of IWBs.

  9. Three-residue turns in alpha/beta-peptides and their application in the design of tertiary structures.

    Science.gov (United States)

    Sharma, Gangavaram V M; Nagendar, Pendem; Ramakrishna, Kallaganti V S; Chandramouli, Nagula; Choudhary, Madavi; Kunwar, Ajit C

    2008-06-02

    A new three-residue turn was serendipitously discovered in alpha/beta hybrid peptides derived from alternating C-linked carbo-beta-amino acids (beta-Caa) and L-Ala residues. The three-residue beta-alpha-beta turn at the C termini, nucleated by a helix at the N termini, resulted in helix-turn (HT) supersecondary structures in these peptides. The turn in the HT motif is stabilized by two H bonds-CO(i-2)-NH(i), with a seven-membered pseudoring (gamma turn) in the backward direction, and NH(i-2)-CO(i), with a 13-membered pseudoring in the forward direction (i being the last residue)--at the C termini. The study was extended to generalize the new three-residue turn (beta-alpha-beta) by using different alpha- and beta-amino acids. Furthermore, the HT motifs were efficiently converted, by an extension with helical oligomers at the C termini, into peptides with novel helix-turn-helix (HTH) tertiary structures. However, this resulted in the destabilization of the beta-alpha-beta turn with the concomitant nucleation of another three-residue turn, alpha-beta-beta, which is stabilized by 11- and 15-membered bifurcated H bonds. Extensive NMR spectroscopic studies were carried out to delineate the secondary and tertiary structures in these peptides, which are further supported by molecular dynamics (MD) investigations.

  10. Beta-and gamma-turns in proteins revisited: a new set of amino acid turn-type dependent positional preferences and potentials.

    Science.gov (United States)

    Guruprasad, K; Rajkumar, S

    2000-06-01

    The number of beta-turns in a representative set of 426 protein three-dimensional crystal structures selected from the recent Protein Data Bank has nearly doubled and the number of gamma-turns in a representative set of 320 proteins has increased over seven times since the previous analysis. Beta-turns (7153) and gamma-turns (911) extracted from these proteins were used to derive a revised set of type-dependent amino acid positional preferences and potentials. Compared with previous results, the preference for proline, methionine and tryptophan has increased and the preference for glutamine, valine, glutamic acid and alanine has decreased for beta-turns. Certain new amino acid preferences were observed for both turn types and individual amino acids showed turn-type dependent positional preferences. The rationale for new amino acid preferences are discussed in the light of hydrogen bonds and other interactions involving the turns. Where main-chain hydrogen bonds of the type NH(i + 3) --> CO(i) were not observed for some beta-turns, other main-chain hydrogen bonds or solvent interactions were observed that possibly stabilize such beta-turns. A number of unexpected isolated beta-turns with proline at i + 2 position were also observed. The NH(i + 2) --> CO(i) hydrogen bond was observed for almost all gamma-turns. Nearly 20% classic gamma-turns and 43% inverse gamma-turns are isolated turns.

  11. Genetic divergence and phylogenetic relationships in grey mullets (Teleostei: Mugilidae) based on PCR-RFLP analysis of mtDNA segments.

    Science.gov (United States)

    Papasotiropoulos, V; Klossa-Kilia, E; Kilias, G; Alahiotis, S

    2002-04-01

    The genetic differentiation and phylogenetic relationships among five species of the Mugilidae family (Mugil cephalus, Chelon labrosus, Liza aurata, Liza ramada, and Liza saliens) were investigated at the mtDNA level, on samples taken from Messolongi lagoon-Greece. RFLP analysis of three PCR-amplified mtDNA gene segments (12s rRNA, 16s rRNA, and CO I) was used. Ten, eight, and nine restriction enzymes were found to have at least one recognition site at 12s rRNA, 16s rRNA, and CO I genes, respectively. Several fragment patterns were revealed to be species-specific, and thus they could be useful in species taxonomy as diagnostic markers, as well as for further evolutionary studies. Seven different haplotypes were detected. The greatest amount of genetic differentiation was observed at the interspecific level, while little variation was revealed at the intraspecific level. The highest values of nucleotide sequence divergence were observed between M. cephalus and all the other species, while the lowest was found between C. labrosus and L. saliens. Dendrograms obtained by the three different methods (UPGMA, Neighbor-Joining, and Dollo parsimony), were found to exhibit in all cases the same topology. According to this, the most distinct species is M. cephalus, while the other species are clustered in two separate groups, thefirst one containing L. aurata and L. ramada, the other L. saliens and C. labrosus. This last clustering makes the monophyletic origin of the genus Liza questionable.

  12. How easy is CO2 fixation by M-C bond containing complexes (M = Cu, Ni, Co, Rh, Ir)?

    KAUST Repository

    Nolan, Steve

    2015-11-27

    A comparison between different M–C bonds (M = Cu(I), Ni(II), Co(I), Rh(I) and Ir(I)) has been reported by using density functional theory (DFT) calculations to explore the role of the metal in the fixation or incorporation of CO2 into such complexes. The systems investigated are various metal based congeners of the Ir-complex 8 [(cod)(IiPr)Ir-CCPh], with a ligand scaffold based on cod and IiPr ligands (cod = 1,5-cyclooctadiene; IiPr = 1,3-bis(isopropyl)imidazol-2-ylidene). The results of this study show that the calculated CO2 insertion barriers follow the trend: Cu(I) (20.8 kcal mol−1) < Rh(I) (30.0 kcal mol−1) < Co(I) (31.3 kcal mol−1) < Ir(I) (37.5 kcal mol−1) < Ni(II) (45.4 kcal mol−1), indicating that the Cu(I) based analogue is the best CO2 fixer, while Ni(II) is the worst in the studied series.

  13. Effects of titanium surface topography on morphology and in vitro activity of human gingival fibroblasts.

    Science.gov (United States)

    Ramaglia, L; Capece, G; Di Spigna, G; Bruno, M P; Buonocore, N; Postiglione, L

    2013-01-01

    The aim of the present study was to evaluate in vitro the biological behavior of human gingival fibroblasts cultured on two different titanium surfaces. Titanium test disks were prepared with a machined, relatively smooth (S) surface or a rough surface (O) obtained by a double acid etching procedure. Primary cultures of human gingival fibroblasts were plated on the experimental titanium disks and cultured up to 14 days. Titanium disk surfaces were analysed by scanning electron microscopy (SEM). Cell proliferation and a quantitative analysis by ELISA in situ of ECM components as CoI, FN and TN were performed. Results have shown different effects of titanium surface microtopography on cell expression and differentiation. At 96 hours of culture on experimental surfaces human gingival fibroblasts displayed a favourable cell attachment and proliferation on both surfaces although showing some differences. Both the relatively smooth and the etched surfaces interacted actively with in vitro cultures of human gingival fibroblasts, promoting cell proliferation and differentiation. Results suggested that the microtopography of a double acid-etched rough surface may induce a greater Co I and FN production, thus conditioning in vivo the biological behaviour of human gingival fibroblasts during the process of peri-implant soft tissue healing.

  14. The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference

    Directory of Open Access Journals (Sweden)

    Cristian-Mihail Niculae

    2016-11-01

    Full Text Available Table of contents A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Bucharest Cristian-Mihail Niculae, Eliza Manea, Raluca Jipa, Simona Merisor, Ruxandra Moroti, Serban Benea, Adriana Hristea A2 Influence of bacteriophages on sessile Gram-positive and Gram-negative bacteria Alina Cristina Neguț, Oana Săndulescu, Anca Streinu-Cercel, Dana Mărculescu, Magdalena Lorena Andrei, Veronica Ilie, Marcela Popa, Coralia Bleotu, Carmen Chifiriuc, Mircea Ioan Popa, Adrian Streinu-Cercel A3 The utility of inflammatory biomarkers in the prognostic evaluation of septic patients – past, present and future Alina Orfanu, Cristina Popescu, Anca Leuștean, Remulus Catană, Anca Negru, Alexandra Badea, Radu Orfanu, Cătălin Tilișcan, Victoria Aramă, Ştefan Sorin Aramă A4 Etiologic and clinical features of bacterial meningitis in infants Constanța-Angelica Vișan, Anca-Cristina Drăgănescu, Anuța Bilașco, Camelia Kouris, Mădălina Merișescu, Magdalena Vasile, Diana-Maria Slavu, Sabina Vintilă, Endis Osman, Alina Oprea, Sabina Sandu, Monica Luminos A5 The diagnostic and prognostic role of neutrophil to lymphocyte count ratio in sepsis Alina Orfanu, Victoria Aramă, Ştefan Sorin Aramă, Anca Leuştean, Remulus Catană, Anca Negru, Gabriel Adrian Popescu, Cristina Popescu A6 Whooping cough in a HIV positive patient Ramona Georgiana Stanculete, Ana Vaduva Enoiu, Adelina Raluca Marinescu, Voichita Lazureanu A7 Cronobacter sakazakii sepsis in varicella patient Adelina-Raluca Marinescu, Alexandru Crișan, Voichița Lăzureanu, Virgil Musta, Narcisa Nicolescu, Ruxandra Laza A8 Anaerobes an underdiagnosed cause of prosthesis joint infection Anca-Ruxandra Negru, Daniela-Ioana Munteanu, Raluca Mihăilescu, Remulus Catană, Olga Dorobăț, Alexandru Rafila, Emilia Căpraru, Marius Niculescu, Rodica Marinescu, Olivera Lupescu, Vlad Predescu, Adrian Streinu-Cercel, Victoria Aramă, Daniela

  15. Influence of Immunology Knowledge on Healthcare and Healthy Lifestyle.

    Directory of Open Access Journals (Sweden)

    Noor Lide Abu Kassim

    Full Text Available Completing a course in Immunology is expected to improve health care knowledge (HCK, which in turn is anticipated to influence a healthy lifestyle (HLS, controlled use of health care services (HCS and an awareness of emerging health care concerns (HCC. This cross-sectional study was designed to determine whether these interrelationships are empirically supported. Participants involved in this study were government servants from two ministries in Malaysia (n = 356 and university students from a local university (n = 147. Participants were selected using the non-random purposive sampling method. Data were collected using a self-developed questionnaire, which had been validated in a pilot study involving similar subjects. The questionnaire items were analyzed using Rasch analysis, SPSS version 21 and AMOS version 22. Results have shown that participants who followed a course in Immunology (CoI had a higher primary HCK (Mean = 0.69 logit, SD = 1.29 logits compared with those who had not (Mean = -0.27logit, SD = 1.26 logits. Overall, there were significant correlations among the HLS, the awareness of emerging HCC, and the controlled use of HCS (p <0.001. However, no significant correlations were observed between primary HCK and the other variables. However, significant positive correlation was observed between primary HCK and controlled use of HCS for the group without CoI. Path analysis showed that the awareness of emerging HCC exerted a positive influence on controlled use of HCS (β = 0.156, p < .001 and on HLS (β = 0.224, p < .001. These findings suggest that having CoI helps increase primary HCK which influences controlled use of HCS but does not necessarily influence HLS. Hence, introducing Immunology at various levels of education and increasing the public awareness of emerging HCC might help to improve population health en masse. In addition, further investigations on the factors affecting HLS is required to provide a better understanding on

  16. Extreme Energy Particle Astrophysics with ANITA-V

    Science.gov (United States)

    Wissel, Stephanie

    This proposal is in collaboration with Peter Gorham at the University of Hawaii, who is the PI of the lead proposal. Co-I Wissel and her group at California Polytechnic State University (Cal Poly) will be responsible for calibration equipment upgrades, calibration equipment, and deployment of the calibration system. The Cal Poly group is planning to provide calibration hardware and software products in support of the analysis of ANITAV data in search of ultra high-energy (UHE) neutrinos and cosmic rays. Wissel (now at Cal Poly, a new collaborating institution for ANITA-5) brings significant experience in the detection of high-energy and ultra-high energy particles to the collaboration, leveraging her thirteen years of experience in particle astrophysics and previous work on ANITA-III and ANITA-IV.

  17. CONTRIBUTION TO THE STATISTICAL INTERPRETATION OF RAW MATERIALS FOR THE CEMENT INDUSTRY OF SPLIT

    Directory of Open Access Journals (Sweden)

    Miroslav Matijaca

    1990-12-01

    Full Text Available Up to the last two decades cement was produced from mari called »tupina« (with about 76% CaCOj which is an ideal mixture for cement production. Due to the quantity decrease of this raw material, cement production went on using the mixture of other members of the flysch series: limestones, marls, clay, loess, sandstones a.o. By the analysis of natural materials the CaCO^ content has mostly been proved. Therefore, knowing the correlation of oxides in mineral raw material is of special significance. The article discusses investigation results of the correlation between CaCO-i and other oxides of the raw material (the paper is published in Croatian.

  18. EDRN Pre-Validation of Multiplex Biomarker in Urine — EDRN Public Portal

    Science.gov (United States)

    The goal of this proposal is to begin to establish an EDRN “pre-validation” trial of a multiplex set of transcripts, including the ETS gene fusions, in post-DRE urine sediments. As can be evidenced by our preliminary data, we have established the utility of this multiplex urine test (which includes TMPRSS-ERG, SPINK1, PCA3 and GOLPH2) in a cohort of prospectively collected urine sediments from the University of Michigan EDRN CEVC site (collected by co-I, Dr. John Wei). In this proposal, we will run this multiplex assay on prospectively collected post-DRE urines collected from other EDRN sites. The idea is to couple this “pre-validation” study with an EDRN validation trial under consideration for the Gen-Probe PCA3 urine test (directed by Drs. John Wei and Harry Rittenhouse).

  19. Real-Time Visualization of Active Species in a Single-Site Metal–Organic Framework Photocatalyst

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Sizhuo [Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201, United States; Pattengale, Brian [Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201, United States; Lee, Sungsik [X-ray Science Division, Argonne National Laboratory, Argonne, Illinois 60349, United States; Huang, Jier [Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201, United States

    2018-02-06

    In this work, we report a new single-site photocatalyst (Co-Ru-UIO- 67(bpy)) based on a metal-organic framework platform with incorporated molecular photosensitizer and catalyst. We show that this catalyst not only demonstrates exceptional activity for light-driven H2 production but also can be recycled without loss of activity. Using the combination of optical transient absorption spectroscopy and in situ X-ray absorption spectroscopy, we not only captured the key CoI intermediate species formed after ultrafast charge transfer from the incorporated photosensitizer but also identified the rate-limiting step in the catalytic cycle, providing insight into the catalysis mechanism of these single-site metal-organic framework photocatalysts.

  20. Measurement of conformational constraints in an elastin-mimetic protein by residue-pair selected solid-state NMR

    International Nuclear Information System (INIS)

    Hong, Mei; McMillan, R. Andrew; Conticello, Vincent P.

    2002-01-01

    We introduce a solid-state NMR technique for selective detection of a residue pair in multiply labeled proteins to obtain site-specific structural constraints. The method exploits the frequency-offset dependence of cross polarization to achieve 13 CO i → 15 N i → 13 Cα i transfer between two residues. A 13 C, 15 N-labeled elastin mimetic protein (VPGVG) n is used to demonstrate the method. The technique selected the Gly3 Cα signal while suppressing the Gly5 Cα signal, and allowed the measurement of the Gly3 Cα chemical shift anisotropy to derive information on the protein conformation. This residue-pair selection technique should simplify the study of protein structure at specific residues

  1. Multielement determination in water by instrumental neutron activation analysis

    International Nuclear Information System (INIS)

    Naeem, A.

    1987-01-01

    INAA technique was applied to a water sample to determine the elemental concentrations. The sample was irradiated with a neutron flux of 1.2x10 12 n cm -2 s -1 for two different decay times, using two coaxial type high-resolution Ge(Li) detectors. The dominant elements determined in the water sample are Ca, Cl, Na, Mg and K present in ppm-level, while Co, I, Mn, Sm, and Sb are present in smaller amounts, approx. on the average 0.01 ppm. Only traces of other elements such as the rare-earths Ag, As, Ba, Cu, Cd, Fe, Sr, W, Zn, seem to be present. (author)

  2. Molecular phylogeny of grey mullets (Teleostei: Mugilidae) in Greece: evidence from sequence analysis of mtDNA segments.

    Science.gov (United States)

    Papasotiropoulos, Vasilis; Klossa-Kilia, Elena; Alahiotis, Stamatis N; Kilias, George

    2007-08-01

    Mitochondrial DNA sequence analysis has been used to explore genetic differentiation and phylogenetic relationships among five species of the Mugilidae family, Mugil cephalus, Chelon labrosus, Liza aurata, Liza ramada, and Liza saliens. DNA was isolated from samples originating from the Messolongi Lagoon in Greece. Three mtDNA segments (12s rRNA, 16s rRNA, and CO I) were PCR amplified and sequenced. Sequencing analysis revealed that the greatest genetic differentiation was observed between M. cephalus and all the other species studied, while C. labrosus and L. aurata were the closest taxa. Dendrograms obtained by the neighbor-joining method and Bayesian inference analysis exhibited the same topology. According to this topology, M. cephalus is the most distinct species and the remaining taxa are clustered together, with C. labrosus and L. aurata forming a single group. The latter result brings into question the monophyletic origin of the genus Liza.

  3. A Comparison Between Actual Parts Usage and Parts Usage Projected in Allowance Parts Lists for Forklift Vehicles

    Science.gov (United States)

    1976-06-01

    to> u o U a a. O eg _ 2. _ a - z i/7 LP _ r— £. i>i <i. n> i. LU a i. tx. >o z O a a EX. z IMIMfM ^, rococo x. -o >o -oooo CMCMCM QOO LU 00 LP LJ r...rnrn rr> r*\\ rn rnm jrt o 1mfrirofnfnrnrOfncnfTXTim C9 CT3^DCOCOOO CD^DCO CS03 ^0 CDCO^OOD CD BO^O 00 OD <~!Q rT**t fT?*T? T? *T? OP CO ROCOCO ID OU CO...I rococo rococo COCO COCO coco I I I I I IOOOOOOOOOOOO I I I I I IUUUOUO CMCM CMCM CM CM -OxJ *UMj sO sU 4C *- o <. n l « «i III «* HJ i. i CM i. CM

  4. Airblast Attenuation in Entranceways and other Typical Components of Structures. Small-Scale Tests Data Report 1

    Science.gov (United States)

    1984-12-01

    CD <^P CO CD CO CO *^D CO CO *S) ^0 ^0 CO CO ^0 ^D r». cocococn^^-cvicncororo OJCO CMtocM«-« M> i —~«CD rococo co<~ coco...I ro rowtoto r».»* coco CM co ro CM rococo GO r^ voco co i a»v coCM<**•co<r>-« i * -•-« i...J 1 1 1 1 1 1 ! 1 1 t • • • rococo CVI**« •* iv.rw^ojrs.oMoooro-«<»eo CVJ CM «-• *-**■<«■* <M v* «■*«*«* CM I I • ••••«••••••I I

  5. Retention of metabolized antimony, cobalt, iodine, mercury, selenium and zinc in various tissues of the rat following freeze-drying and oven-drying at different temperatures

    International Nuclear Information System (INIS)

    Iyengar, G.V.; Kasperek, K.; Feinendegen, L.E.

    1977-01-01

    Loss of Sb, Co, I, Hg, Se, and Zn during freeze-drying and oven-drying at 80 0 C, 105 0 C, and 120 0 C were studied in rat tissues that contained metabolized radioactive isotopes. No loss was observed for any of the 6 elements on freeze-drying. However, tissue-specific differences were observed in many cases for the elements Hg, Se, I, and Sb on oven-drying. Although the losses were statistically significant, they remained in most cases between 2 and 10%, with the exception of Hg at 120 0 C, where the losses in some of the tissues were unpredictable. With respect to urine, freeze-drying and oven-drying at 80 0 C were found to be relatively safe for the elements Hg and I. At 105 0 C and above, serious loss of Hg was observed. For Se only freeze-drying was found to be safe

  6. Coordination compounds of cobalt and cadmium with isobutyric acid amide

    Energy Technology Data Exchange (ETDEWEB)

    Tsivadze, A.Yu.; Ivanova, I.S.; Solovkina, O.A. (AN SSSR, Moscow. Inst. Obshchej i Neorganicheskoj Khimii)

    1983-06-01

    Coordination compounds of cobalt and cadmium with isobutyric acid amide (IBAA) of Co(NCS)/sub 2/x(IBAA)/sub 2/(H/sub 2/O)/sub 2/, CoCl/sub 2/(IBAA)/sub 4/, CoI/sub 2/(IBAA)/sub 8/(H/sub 2/O)/sub 2/, CdI/sub 2/(IBAA)/sub 2/ composition have been synthesized and characterized. Their infrared absorption spectra (200-400 cm/sup -1/), electron reflection spectra (200-750 nm) were studied. It is shown that in all compounds there are IBAA molecUles coordinated through an oxygen atom. Thiocyanogroups are coordinated through nitrogen atoms.

  7. Waterborne Transportation Lines of the United States, 1989. Annual Revision

    Science.gov (United States)

    1990-12-14

    18.0!NONE !NY NEW YORK 1 1956 1 120.0! 36.0! 4.0! 1 - ! I ! I I I ! ! ! ! ! ’ ! ! (32) COP MARISE SERV. AT LAPLIACK ! I ! ! ! I I I I I JUDITH AN...1 29!4A46! 54.0! 15.1! 4.3! If! 3! 0.9!NONE ICY WETHERS - 1 19551 I I I 1 14.0! 15.1! 2.0! 1 20! 1 1 FIELDO (32) CONOCO, INC.! ! ! ! ! ! ! APACHE...COAST !INC. I I I T OINTERSTATE NAVIGATION CO. !I IPASSN’ERS, VEHICLES, AND FREIGHT !POINT JUDITH TO BLOCK ISLAND. Rt; PROVIDENCE, * I I INEWPOOT, BLOCK

  8. A Transport and Diffusion Model for Smoke Munitions.

    Science.gov (United States)

    1979-08-01

    oo cri r^ <a- CM «1- »*■ l-H CO in en oo in cri vo Tt 4- CO CO i-) CM tD Z LU —I ts Z O LU Z2 O _l Q (_> =3 O LU _l S» O I-H I...DX * ^ Pox -xceMTPOO/^*^11-) + DY*CP(»y - ycr»JTP(^J)/<SVdti- s = -BA t- apis- zstA/Jj/JiCr))1’ ct = C--^*cJ //=• ^cc - ue. -zr) GO TD s5?? P...50 FORMAT(1101 PRINT m.NRPV 14 FORMAT! IHQ , •NUMBER Of ROUNDS PER VOLLEY ’.It/ ? IHO.-IDEAL IMPACT POINTS •/ ’ •O".’ NO. •,6X

  9. The nido-osmaboranes [2,2,2-(CO)(PPh(3))(2)-nido-2-OsB(5)H(9)] and [6,6,6-(CO)(PPh(3))(2)-nido-6-OsB(9)H(13)].

    Science.gov (United States)

    Bould, J; Kennedy, J D; Thomas, R L; Rath, N P; Barton, L

    2001-11-01

    The structural characterization of the osmahexaborane 2-carbonyl-2,2-bis(triphenylphosphine)-nido-2-osmahexaborane(9), [Os(B(5)H(9))(C(18)H(15)P)(2)(CO)], (I), a metallaborane analogue of B(6)H(10), confirms the structure proposed from NMR spectroscopy. The structure of the osmadecaborane 6-carbonyl-6,6-bis(triphenylphosphine)-nido-6-osmadecaborane(13), [Os(B(9)H(13))(C(18)H(15)P)(2)(CO)], (IV), is similarly confirmed. The short basal B-B distance of 1.652 (8) A in (I), not bridged by an H atom, mirrors that in the parent hexaborane(10) [1.626 (4) A].

  10. Dollar Summary of Prime Contract Awards by State, County, Contractor and Place. Part 2 (Alachua-Menominee)

    Science.gov (United States)

    1990-01-01

    0c -4 -40)4- * L Iit m * 40 404 CD to I 4 0)0m (a 04) a~ CV -1*c 𔃾 I4 C)II tun I nco -4 0V) C) m 0 01~~~~~e CO I ON N000 N0l I2I4 N 0 CO In 40) - 0 0...WO a.I-1W z o -0z zw1- " WWM4- oo mx04C’)4Ua Ŕ(1~f 0004-NBaN’a004’N004-4-0Z flC’ Wa K- ) II= 0 I N a N(𔃻P- zAw ~ 0 -aQfl4-4N 0 a -00(’)0t7- N ofa a0

  11. Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (General Image Engineering Corp - H E H Heins GMBH)

    Science.gov (United States)

    1993-01-01

    CDO-4 zaw O il E sOO Mcq it 0 0 0 0 0 0D (’AN 00 ɜ 1 MI 10 3a’COON U.L 1-1 Ui. 4 -. C>O - LA- WA 1-1 La-O)OC 1-14- Wr2CO iO z- 0 0) 01 a 00 0 0 0 0 4...0 c) tun r- 1-1 In a) cli In r- f-- to <> V) r- r- I- -i ,1 14 ed < o c) 11 00 (0 (0 (D (10 Z) (0 00 0 C> o C> 00 (Tf o 00 C) C, 00 qzr 00-4 r- t- P

  12. Preparação e caracterização do complexo cobaloxima e sua utilização na construção de um eletrodo modificado: um experimento eletroquímico no curso de graduação Preparation and characterization of the cobaloxime complex and its use in fabrication of a modified electrode: an electrochemical experiment for undergraduate course

    Directory of Open Access Journals (Sweden)

    Claudemir A. Borgo

    2003-12-01

    Full Text Available The present experiment describes the preparation, characterization of n-butyl(pyridilcobaloxime complex and its electrochemical property. The infrared and uv-visible absorption spectra were used to characterize the complex obtained. The infrared spectrum of the compound showed characteristics bands that indicated the formation of the Co-C chemical bond formation. The electronic absorption spectrum in acetonitrile showed transition bands attributed to p-p*, metal-to-ligand charge transfer, d-d transitions and charge transfer Co-C. The electrochemical property was investigated by the pulse differential voltammetry technique. Two oxidation processes: Co(I/Co(II at -423 mV and Co(II/Co(III at 752 mV were observed.

  13. Vitamin B12-catalyzed synthesis of some peracetylated alkyl b-D-xylopyranosides

    Directory of Open Access Journals (Sweden)

    LJILJANA STEVANOVIC

    2003-10-01

    Full Text Available The vitamin B12-catalyzed glycosylation reaction of brominated b-D-xylose peracetate with alkanols ROH (C1-C8 has been studied. The catalytically active species in this reaction was cob(Ialamin, obtained by chemical reduction of Vitamin B12 with NaBH4 (Co(III to Co(I. The reaction was carried out with 2 mol% of vitamin B12, with respect to xylosyl bromide 1, under argon at room temperature. Under these conditions, peracetylated C1-C8-alkyl b-D-xylopyranosides (3a–3f were obtained in moderate yield (55–70 %. In all cases 3,4-di-O-acetyl-D-xylal (4 was obtained, as the product of reductive elimination of peracetylated xylosyl bromide (15–25 %.

  14. Compilation of 1990 Annual Reports of the Navy ELF Communications System Ecological Monitoring Program. Volume 3. Tabs G thru I.

    Science.gov (United States)

    1991-08-01

    crowned Kinglet 12 11 1 3 5 0 0 9 3 4 i Reciulus calendula _Gnatcatcher 0 1 0 0 0 0 00 0Blue-grayGattce Polioptila caerulea Eastern Bluebird 0 0 0 0 1 0 6 0...and species determinations was done at 1250X magnification on a Zeiss microscope equipped with phase contrast illumination and an oil immersion 10OX...xx MMN M M N NŘ N NMN NM M N II~ ~ 0 a MM NM 333 30661 6961 x x x 39961 x x xK x x S996 x K K U I *c E I I. i~~ 0* oil ] o o I4 33 0) x LL 5 I. CoI

  15. Comments about "Earth 3.0"

    Science.gov (United States)

    Dator, Jim

    2006-01-01

    Dr. Christopher P. McKay, Planetary Scientist with the Space Science Division of NASA Ames. Chris received his Ph.D. in AstroGeophysics from the University of Colorado in 1982 and has been a research scientist with the NASA Ames Research Center since that time. His current research focuses on the evolution of the solar system and the origin of life. He is also actively involved in planning for future Mars missions including human exploration. Chris been involved in research in Mars-like environments on Earth, traveling to the Antarctic dry valleys, Siberia, the Canadian Arctic, and the Atacama desert to study life in these Mars-like environments. His was a co-I on the Titan Huygen s probe in 2005, the Mars Phoenix lander mission for 2007, and the Mars Science Lander mission for 2009.

  16. Temperature-induced itinerant-electron metamagnetism in ErCo3 studied by neutron diffraction

    International Nuclear Information System (INIS)

    Gratz, E.; Markosyan, A.S.; Gaidukova, I.Yu.; Rodimin, V.E.; Paul-Boncour, V.; Hoser, A.; Stuesser, N.

    2002-01-01

    Powder neutron diffraction studies in the temperature range from 2 K to 450 K of the ferrimagnetic ErCo 3 compound (T C =401 K) revealed an increase of the unit-cell volume at 100 K (T m ) when cooling down (ΔV/V∼4 x 10 -3 ). This is referred to as a temperature-induced change in the Co sublattice magnetization from a low-magnetic state (T>T m ) to a high-magnetic state (T m ). From the temperature variation of the sublattice magnetization (ErI (3a sites), ErII (6c), CoI (3b), CoII (6c) and CoIII (18h)) it was found that the Co moments at the 6c and 18h sites change near 100 K, giving rise to the volume anomaly at T m . A qualitative discussion of the mechanism behind this phenomenon is given. (orig.)

  17. Two-electron oxidation of cobalt phthalocyanines by thionyl chloride: Implications for lithium/thionyl chloride batteries. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    Bernstein, P.A.; Lever, A.B.

    1989-10-20

    Cyclic voltammetry, DPV and electronic spectroscopy are used to study the reaction between thionyl chloride and cobalt phthalocyanine. SOCl2 reacts with (Co(I)Tn Pc(2-)) and Co(II)Tn Pc(2-) to give two-electron oxidized species. Implications for Li/SOCl2 batteries are discussed. Thionyl chloride also forms a mono SOCl2 adduct with Co(II)TnPc(2-). Driving forces (Delta E values) were calculated for CoTnPc comproportionation and CoTnPc + SOCl2 reactions. Rest potential measurements of a Li/SOCl2 cells show that addition of AlCl3 stabilizes the LiCl product as LiAlCl4. A catalytic two-electron mechanism is indicated for the reduction of thionyl chloride in a Li/SOCl2/(CoTnPc,C) battery.

  18. MODEL PENELITIAN HUBUNGAN POLA PERMUKIMAN DAN KONFLIK ANTAR ETNIK

    Directory of Open Access Journals (Sweden)

    Emilya Kalsum

    2015-01-01

    . Rineka Cipta. Doxiadis. 1974. “Action For A Better Scientific Approach To The Subject Of Human Settlements" The Journal of Ekistics. Volume 38. No. 229. Desember 1974. Drever, James. 1986. Kamus Psikologi. Jakarta: Bina Aksara. Ellen, Ingrid Gould. 2000. "Race-Based Neighborhood Projection: A Pro-posed Framework for Understanding New Data On Racial Integration”., Urban Studies. Vol. 37, No. 9. p. 1513 – 1533. Friedrichs, Jurgen. 1998. "Ethic Segregation In Cologne, Germany, 1984-94". Urban Studies. Vol. 35 No. 10. p.1745 – 1763. Hardjosudarmo, Soedigdo. 1965. Kebijak-sanaan Transmigrasi Dalam Rangka Pembangunan Masyarakat Desa Indonesia. Jakarta: Yayasan Obor. Haryadi & B. Setiawan. 1995. Arsitektur Lingkungan dan Perilaku, Suatu Pengantar Ke Teori, Metodologi dan Aplikasi. Direktorat Jenderal Pendidikan Tinggi Departemen Pendidikan dan Kebudayaan. Heeren, H.H. 1979. Transmigrasi di Indonesia. Jakarta: Gramedia. Indonesia, Depnakertrans, Badan Penelitian dan Pengembangan. 1978. Laporan Penelitian Bentuk-bentuk Interaksi Sosial Antar Kelompok Etnik di Daerah Transmigrasi 1977/1978. Jakarta. Kartono, Kartini dan Gulo, Dali. 1987. Kamus Psikologi. Bandung: Pionir Jaya. Kempen, R. Van dan Ozuekren, Sule. 1998. "Ethnic Segregation In Cities: New Forms And Explanation In A Dynamic World". Urban Studies. University of Glasgow. Vol. 35. No. 10. Koetjaraningrat. 1974. Manusia dan Kebudayaan di Indonesia. Jakarta: Jambatan. Minnery, J.R. 1986. "Urban Planners And Role Conflicts". Journal Of Urban Policy And Research. Murdie, Robert A. & Borgegard, Lars-Erik. 1998. “Immigration Spatial Segrega-tion and Housing Segmentation Of Immigrants In Metropolitan Stockholm, 1960-95". Urban Studies, Vol. 35, No. 10, p. 1869 – 1888. Owusu, Thomas Y. 1999. “Residential Patterns and Housing Choices of Ghanaian Immigrants in Toronto, Canada”. Housing Studies. Vol. 14, No. 1. 1999. Pattiselanno, J.Th.F. 1999. “Tradisi Uli, Pela dan Gandong pada Masyarakat Seram, Ambon dan Uliase

  19. Cu–Co–O nano-catalysts as a burn rate modifier for composite solid propellants

    Directory of Open Access Journals (Sweden)

    D. Chaitanya Kumar Rao

    2016-08-01

    Full Text Available Nano-catalysts containing copper–cobalt oxides (Cu–Co–O have been synthesized by the citric acid (CA complexing method. Copper (II nitrate and Cobalt (II nitrate were employed in different molar ratios as the starting reactants to prepare three types of nano-catalysts. Well crystalline nano-catalysts were produced after a period of 3 hours by the calcination of CA–Cu–Co–O precursors at 550 °C. The phase morphologies and crystal composition of synthesized nano-catalysts were examined using Scanning Electron Microscope (SEM, Energy Dispersive Spectroscopy (EDS and Fourier Transform Infrared Spectroscopy (FTIR methods. The particle size of nano-catalysts was observed in the range of 90 nm–200 nm. The prepared nano-catalysts were used to formulate propellant samples of various compositions which showed high reactivity toward the combustion of HTPB/AP-based composite solid propellants. The catalytic effects on the decomposition of propellant samples were found to be significant at higher temperatures. The combustion characteristics of composite solid propellants were significantly improved by the incorporation of nano-catalysts. Out of the three catalysts studied in the present work, CuCo-I was found to be the better catalyst in regard to thermal decomposition and burning nature of composite solid propellants. The improved performance of composite solid propellant can be attributed to the high crystallinity, low agglomeration and lowering the decomposition temperature of oxidizer by the addition of CuCo-I nano-catalyst.

  20. High temperature monitoring of silicon carbide ceramics by confocal energy dispersive X-ray fluorescence spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Li, Fangzuo; Liu, Zhiguo; Sun, Tianxi, E-mail: stx@bnu.edu.cn

    2016-04-15

    Highlights: • X-ray scattering was used for monitoring oxidation situation of SiC ceramics. • A calibration curve was obtained. • The confocal X-ray scattering technology was based on polycapillary X-ray optics. • The variations of contents of components of SiC ceramics were obtained. - Abstract: In the present work, we presented an alternative method for monitoring of the oxidation situation of silicon carbide (SiC) ceramics at various high temperatures in air by measuring the Compton-to-Rayleigh intensity ratios (I{sub Co}/I{sub Ra}) and effective atomic numbers (Z{sub eff}) of SiC ceramics with the confocal energy dispersive X-ray fluorescence (EDXRF) spectrometer. A calibration curve of the relationship between I{sub Co}/I{sub Ra} and Z{sub eff} was established by using a set of 8 SiC calibration samples. The sensitivity of this approach is so high that it can be easily distinguished samples of Z{sub eff} differing from each other by only 0.01. The linear relationship between the variation of Z{sub eff} and the variations of contents of C, Si and O of SiC ceramics were found, and the corresponding calculation model of the relationship between the ΔZ and the ΔC{sub C}, ΔC{sub Si}, and ΔC{sub O} were established. The variation of contents of components of the tested SiC ceramics after oxidation at high temperature was quantitatively calculated based on the model. It was shown that the results of contents of carbon, silicon and oxygen obtained by this method were in good agreement with the results obtained by XPS, giving values of relative deviation less than 1%. It was concluded that the practicality of this proposed method for monitoring of the oxidation situation of SiC ceramics at high temperatures was acceptable.

  1. Power programmes review: Nuclear power in Italy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1959-07-15

    Several concrete measures have been initiated in Italy for the generation of nuclear power on a substantial scale. Two plants are already under construction and work will start soon on a third. Plans have also been announced for more stations. If the work already initiated is completed on schedule the installed capacity of nuclear power in Italy is likely to exceed 500 mw (electric) in the course of the next four years. This will constitute a sizeable proportion of the total electrical capacity in the country. After the Italian National Committee for Nuclear Research (Comitato Nazionale per le Ricerche Nucleari) was reorganized late in 1956, it prepared what can be described as a nuclear five-year plan for Italy. The plan, designed to cover the period 1957-1962, includes detailed schemes for a comprehensive development of the peaceful uses of nuclear energy, including a programme for the generation of power. The Comitato Nazionale per le Ricerche Nucleari (CNRN) promotes and co-ordinates the various activities in the field, and within the framework of its general programme certain industrial groups in Italy have formulated specific projects for nuclear power. At a Geneva conference (1958) it was disclosed that several companies were planning to build nuclear power stations in Italy. (1) SELNI (Societa Elettronucleare Italiana), pertaining to the Edison-Volta group, which plans to build a pressurized water reactor. (2) So.R.I.N. (Societa Ricerche Impianti Nucleari), a company founded by the Fiat and Montecatini groups, which is constructing a research centre, with a swimming pool reactor, and various laboratories for chemistry, physics and metallurgy. This centre will also be used for the training of specialized personnel, in view of the company's programme which envisages two 150 mw (e) plants: one operating with enriched uranium, the other with natural uranium. Such a programme will become effective only when the cost of power produced by these plants may actually

  2. How does knowledge of three-dimensional excision margins following breast conservation surgery impact upon clinical target volume definition for partial-breast radiotherapy?

    International Nuclear Information System (INIS)

    Kirby, Anna M.; Evans, Philip M.; Nerurkar, Ashutosh Y.; Desai, Saral S.; Krupa, Jaroslaw; Devalia, Haresh; Rovere, Guidubaldo Querci della; Harris, Emma J.; Kyriakidou, Julia; Yarnold, John R.

    2010-01-01

    Background and purpose: To compare partial-breast clinical target volumes generated using a standard 15 mm margin (CTV standard ) with those generated using three-dimensional surgical excision margins (CTV tailored30 ) in women who have undergone wide local excision (WLE) for breast cancer. Material and methods: Thirty-five women underwent WLE with placement of clips in the anterior, deep and coronal excision cavity walls. Distances from tumour to each of six margins were measured microscopically. Tumour bed was defined on kV-CT images using clips. CTV standard was generated by adding a uniform three-dimensional 15 mm margin, and CTV tailored30 was generated by adding 30 mm minus the excision margin in three-dimensions. Concordance between CTV standard and CTV tailored30 was quantified using conformity (CoI), geographical-miss (GMI) and normal-tissue (NTI) indices. An external-beam partial-breast irradiation (PBI) plan was generated to cover 95% of CTV standard with the 95% isodose. Percentage-volume coverage of CTV tailored30 by the 95% isodose was measured. Results: Median (range) coronal, superficial and deep excision margins were 15.0 (0.5-76.0) mm, 4.0 (0.0-60.0) mm and 4.0 (0.5-35.0) mm, respectively. Median CoI, GMI and NTI were 0.62, 0.16 and 0.20, respectively. Median coverage of CTV tailored30 by the PBI-plan was 97.7% (range 84.9-100.0%). CTV tailored30 was inadequately covered by the 95% isodose in 4/29 cases. In three cases, the excision margin in the direction of inadequate coverage was ≤2 mm. Conclusions: CTVs based on 3D excision margin data are discordant with those defined using a standard uniform 15 mm TB-CTV margin. In women with narrow excision margins, the standard TB-CTV margin could result in a geographical miss. Therefore, wider TB-CTV margins should be considered where re-excision does not occur.

  3. Computational, electrochemical, and spectroscopic studies of two mononuclear cobaloximes: the influence of an axial pyridine and solvent on the redox behaviour and evidence for pyridine coordination to cobalt(I) and cobalt(II) metal centres†

    Science.gov (United States)

    Lawrence, Mark A. W.; Celestine, Michael J.; Artis, Edward T.; Joseph, Lorne S.; Esquivel, Deisy L.; Ledbetter, Abram J.; Cropek, Donald M.; Jarrett, William L.; Bayse, Craig A.; Brewer, Matthew I.; Holder, Alvin A.

    2018-01-01

    [Co(dmgBF2)2(H2O)2] 1 (where dmgBF2 = difluoroboryldimethylglyoximato) was used to synthesize [Co(dmgBF2)2(H2O)(py)]·0.5(CH3)2CO 2 (where py = pyridine) in acetone. The formulation of complex 2 was confirmed by elemental analysis, high resolution MS, and various spectroscopic techniques. The complex [Co(dmgBF2)2(solv)(py)] (where solv = solvent) was readily formed in situ upon the addition of pyridine to complex 1. A spectrophotometric titration involving complex 1 and pyridine proved the formation of such a species, with formation constants, log K = 5.5, 5.1, 5.0, 4.4, and 3.1 in 2-butanone, dichloromethane, acetone, 1,2-difluorobenzene/acetone (4 : 1, v/v), and acetonitrile, respectively, at 20 °C. In strongly coordinating solvents, such as acetonitrile, the lower magnitude of K along with cyclic voltammetry, NMR, and UV-visible spectroscopic measurements indicated extensive dissociation of the axial pyridine. In strongly coordinating solvents, [Co(dmgBF2)2(solv)(py)] can only be distinguished from [Co(dmgBF2)2(solv)2] upon addition of an excess of pyridine, however, in weakly coordinating solvents the distinctions were apparent without the need for excess pyridine. The coordination of pyridine to the cobalt(II) centre diminished the peak current at the Epc value of the CoI/0 redox couple, which was indicative of the relative position of the reaction equilibrium. Herein we report the first experimental and theoretical 59Co NMR spectroscopic data for the formation of Co(I) species of reduced cobaloximes in the presence and absence of py (and its derivatives) in CD3CN. From spectroelectrochemical studies, it was found that pyridine coordination to a cobalt(I) metal centre is more favourable than coordination to a cobalt(II) metal centre as evident by the larger formation constant, log K = 4.6 versus 3.1, respectively, in acetonitrile at 20 °C. The electrosynthesis of hydrogen by complexes 1 and 2 in various solvents demonstrated the dramatic effects of the axial

  4. The NEA sorption data base (SDB)

    International Nuclear Information System (INIS)

    Ruegger, B.; Ticknor, K.

    1992-01-01

    The current NEA Sorption Data Base is developed to replace the former International Sorption Information Retrieval System (ISIRS) initiated at Pacific Northwest Laboratory and contains about 11,000 distribution coefficients with corresponding experimental condition parameters describing sorption of key nuclides for a large variety of solid and liquid phases. The SDB is designed to run on a micro-computer using the commercially available database software dBASE III Plus. For each recorded sorption experiment, the SDB provides a bibliographical reference, the most complete characterization of the solid and liquid phases available, a description of the experimental conditions and the distribution coefficient or retardation factor for each element studied. When available, parameters such as temperature, initial radionuclide concentration, pH, Eh, contact time, solid to solution ratio, sample origin, oxidation state and type of solution are included. The SDB provides information for a wide variety of rocks or geological materials, buffer backfill candidates, concretes/cements, elements (Am, Cs, Co, I, Np, Pu, Ra, Sr, Se, Tc, U and, to a lesser extent, Ag, Ba, C, Ce, Eu, Fe, Mn, Mo, Na, Nb, Ni, Pd, Pm, Ru, Sb, Sn, Y, Zn, and Zr), or radioisotopes. A compilation of sorption data like SDB provide a readily available source of data for radioactive waste repository performance assessments when site specific data are not available or essential, for example, during a site selection phase. 2 appendices

  5. “Anders And, han virker så dansk” -At vokse op med Disney i Danmark

    Directory of Open Access Journals (Sweden)

    Anne Mette Stevn

    1999-09-01

    Full Text Available Siden Mickey Mouse først så dagens lys i 1928, har Walt Disneys figurer og eventyruniverser bredt sig til hele jordkloden: Anders And, Mickey Mouse, Snehvide, Simba, Tarzan m.fl. Indtil for 10-15 år siden var den normale Disneyoplevelse for en dansker først og fremmest knyttet til det skriftlige medie, nemlig tegneserie-bladene og især Anders And & Co. I dag er 'Disneykulturen' en stærk flerarmet mediekultur, som går på tværs af generationer og krydser landegrænser; og Disneys tilstedeværelse i børns populærkultur i næsten hele verden er blevet meget mere omfat- tende, siden eventyrets begyndelse i 1920erne. I denne artikel belyser Anne Mette Stevn gennem en historisk orienteret receptionsanalyse, hvorledes danskernes brug og oplevelse af Disneys produkter har ud- viklet sig.

  6. Development of CHARMM-Compatible Force-Field Parameters for Cobalamin and Related Cofactors from Quantum Mechanical Calculations.

    Science.gov (United States)

    Pavlova, Anna; Parks, Jerry M; Gumbart, James C

    2018-02-13

    Corrinoid cofactors such as cobalamin are used by many enzymes and are essential for most living organisms. Therefore, there is broad interest in investigating cobalamin-protein interactions with molecular dynamics simulations. Previously developed parameters for cobalamins are based mainly on crystal structure data. Here, we report CHARMM-compatible force field parameters for several corrinoids developed from quantum mechanical calculations. We provide parameters for corrinoids in three oxidation states, Co 3+ , Co 2+ , and Co 1+ , and with various axial ligands. Lennard-Jones parameters for the cobalt center in the Co(II) and Co(I) states were optimized using a helium atom probe, and partial atomic charges were obtained with a combination of natural population analysis (NPA) and restrained electrostatic potential (RESP) fitting approaches. The Force Field Toolkit was used to optimize all bonded terms. The resulting parameters, determined solely from calculations of cobalamin alone or in water, were then validated by assessing their agreement with density functional theory geometries and by analyzing molecular dynamics simulation trajectories of several corrinoid proteins for which X-ray crystal structures are available. In each case, we obtained excellent agreement with the reference data. In comparison to previous CHARMM-compatible parameters for cobalamin, we observe a better agreement for the fold angle and lower RMSD in the cobalamin binding site. The approach described here is readily adaptable for developing CHARMM-compatible force-field parameters for other corrinoids or large biomolecules.

  7. Transfer factors of radionuclides from Andosols to crops

    International Nuclear Information System (INIS)

    Ban-nai, Tadaaki; Muramatsu Yasuyuki

    2004-01-01

    Transfer factors (TFs) of some selected radionuclides from Andosols, a typical soil type in Japan, to several crops (leaf vegetables and root vegetables) have been studied by radiotracer experiments. Cabbages, komatsuna, spinach and lettuce were used as leaf vegetables and radish, carrot and turnip were used as root vegetables. The mean values of TFs (on a wet weight basis) of radionuclides such as 137 Cs, 85 Sr, 60 Co, 54 Mn, 65 Zn and 125 I for edible parts of leaf vegetables were 0.11, 0.24, 0.046, 0.60, 0.51 and 0.0054, respectively. Respective values for edible parts of root vegetables were 0.02, 0.14, 0.004. 0.09, 0.13 and 0.0022. The obtained TFs were, in most cases in the order Mn, Zn, Sr>Cs>Co>I. The TFs of 125 I were much lower than the other nuclides. The transfer factors obtained for the edible part of root vegetables were markedly lower than those for leaf vegetables. The transfer factors of Sr and Mn for leaf vegetables were generally higher for older (outer) leaves than younger (inner) ones. In the root vegetables, TFs for leaf parts were typically higher than those for tubers. (author)

  8. Black-to-Transmissive Electrochromism with Visible-to-Near-Infrared Switching of a Co(II)-Based Metallo-Supramolecular Polymer for Smart Window and Digital Signage Applications.

    Science.gov (United States)

    Hsu, Chih-Yu; Zhang, Jian; Sato, Takashi; Moriyama, Satoshi; Higuchi, Masayoshi

    2015-08-26

    Black-to-transmissive electrochromism has been obtained with a Co(II)-based metallo-supramolecular polymer (polyCo). Thin films of polyCo, based on bisterpyridine ligand assembled with Co(II) metal ion, were constructed by spray casting the polymer onto ITO glass. With such simple fabricating means to form good-quality films, polyCo films show stable switching at the central metal ion of the Co(II)/Co(I) redox reaction when immersed in aqueous solution. With an increase in the pH of the aqueous electrolyte solution from neutral, the film exhibits a color response due to the interaction between the d-orbital electron and hydroxide ions affecting the d-d* transition. As a result, a nearly transparent-to-black electrochromic performance can be achieved with a transmittance difference at 550 nm of 74.3% (81.9-7.6%) in pH 13 solution. The light absorption of the film can be tuned over light regions from visible to near-infrared with a large attenuation.

  9. 3D And 4D Cloud Lifecycle Investigations Using Innovative Scanning Radar Analysis Methods. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kollias, Pavlos [Stony Brook Univ., NY (United States)

    2017-04-23

    With the vast upgrades to the ARM program radar measurement capabilities in 2010 and beyond, our ability to probe the 3D structure of clouds and associated precipitation has increased dramatically. This project build on the PI's and co-I's expertisein the analysis of radar observations. The first research thrust aims to document the 3D morphological (as depicted by the radar reflectivity structure) and 3D dynamical (cloud$-$scale eddies) structure of boundary layer clouds. Unraveling the 3D dynamical structure of stratocumulus and shallow cumulus clouds requires decomposition of the environmental wind contribution and particle sedimentation velocity from the observed radial Doppler velocity. The second thrust proposes to unravel the mechanism of cumulus entrainment (location, scales) and its impact on microphysics utilizing radar measurements from the vertically pointing and new scanning radars at the ARM sites. The third research thrust requires the development of a cloud$-$tracking algorithm that monitors the properties of cloud.

  10. E-Learning dengan Menggunakan COI Framework

    Directory of Open Access Journals (Sweden)

    Lydiawati Kosasih

    2013-12-01

    Full Text Available This study discusses some considerations in education to achieve a good quality of learning by utilizing technological advances such as E-Learning. This study uses a model of Community of Inquiry (COI as a comparative study to improve the quality of E-Learning program. Implementation of COI model in discussionforum on BiNusMaya through E-Learning is able to improve the quality of a discussion as improvement of knowledge management. This study aims to provide a proposal to the Department of Information Systems Bina Nusantara University in enhancing the effectiveness of the use of discussion forums on BiNusMaya (ELearning. By presenting the survey results related to the Binusmaya current condition,s such constraints and development expectations of both the lecturers and students for Binusmaya can be described. In addition, theapplication of CoI model is presented in a learning process especially when meeting outside of class (without face-to-face. The results of this study is expected to be the basis for developing a COI model design and implementation plan in Management Information Systems course, that may improve the quality of the use of discussion forums as part of the knowledge management process in future study.

  11. Communicative-pragmatic impairment in schizophrenia: Cognitive rehabilitative training

    Directory of Open Access Journals (Sweden)

    Francesca Marina Bosco

    2016-02-01

    Full Text Available This paper aims to verify in patients with schizophrenia, the efficacy of Cognitive Pragmatic Treatment (CPT, a new remediation program for improving communicative-pragmatic abilities. The CPT program consists of 20 group sessions, focused on several communication modalities, i.e. linguistic, extralinguistic and paralinguistic, Theory of Mind (ToM and other cognitive functions that can affect communicative performance, such as awareness and planning. A group of 17 patients with schizophrenia participated in the training. They were tested before and after training, using the equivalent forms of the Assessment Battery for Communication (ABaCo, a tool for evaluating the comprehension and production of a wide range of pragmatic phenomena such as, i.e. direct and indirect speech acts, irony and deceit, and a series of neuropsychological and ToM tests. The results showed a significant improvement in patients’ performance following the program, on both comprehension and production tasks, and in all the communication modalities assessed by the ABaCo, i.e. linguistic, extralinguistic, paralinguistic and social appropriateness. The improvement of patients’ performance persisted after three months from the end of the training, as shown by the follow-up tests. These preliminary findings support the efficacy of the CPT program in improving communicative-pragmatic abilities in the patients.

  12. Analytical electrochemistry of vitamin B12 on a bismuth-film electrode surface

    International Nuclear Information System (INIS)

    Kreft, Gabriel L.; Braga, Otoniel C. de; Spinelli, Almir

    2012-01-01

    Cyclic voltammetry (CV) and square wave adsorptive stripping voltammetry (SWAdSV) were used to investigate the performance of an ex situ plated bismuth-film electrode (BiFE) employed to study the electrochemical behavior and the electroanalytical determination of vitamin B 12 . Two pH-dependent reversible peaks were observed for the B 12r –B 12s (Co(II)–Co(I)) couple after pre-concentration of vitamin B 12 at −1.2 V for 30 s. An adsorption-controlled reaction rate with one electron involved in the electrochemical step was observed for the mechanism implicated. The calibration curve obtained in a Britton–Robinson solution at pH 12.0 was linear in the concentration range of 0.100–1.000 μmol L −1 (r = 0.9980). The detection limit was found to be 33.1 nmol L −1 . The electrode was successfully employed for the determination of vitamin B 12 in two pharmaceutical products. The electrode performance was compared with those of modified and unmodified electrodes as well as with the UV–vis spectrophotometric method.

  13. Kinetic neoclassical transport in the H-mode pedestal

    Energy Technology Data Exchange (ETDEWEB)

    Battaglia, D. J.; Chang, C. S.; Ku, S.; Grierson, B. A. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, New Jersey 08540 (United States); Burrell, K. H.; Grassie, J. S. de [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States)

    2014-07-15

    Multi-species kinetic neoclassical transport through the QH-mode pedestal and scrape-off layer on DIII-D is calculated using XGC0, a 5D full-f particle-in-cell drift-kinetic solver with self-consistent neutral recycling and sheath potentials. Quantitative agreement between the flux-driven simulation and the experimental electron density, impurity density, and orthogonal measurements of impurity temperature and flow profiles is achieved by adding random-walk particle diffusion to the guiding-center drift motion. The radial electric field (E{sub r}) that maintains ambipolar transport across flux surfaces and to the wall is computed self-consistently on closed and open magnetic field lines and is in excellent agreement with experiment. The E{sub r} inside the separatrix is the unique solution that balances the outward flux of thermal tail deuterium ions against the outward neoclassical electron flux and inward pinch of impurity and colder deuterium ions. Particle transport in the pedestal is primarily due to anomalous transport, while the ion heat and momentum transport are primarily due to the neoclassical transport. The full-f treatment quantifies the non-Maxwellian energy distributions that describe a number of experimental observations in low-collisionallity pedestals on DIII-D, including intrinsic co-I{sub p} parallel flows in the pedestal, ion temperature anisotropy, and large impurity temperatures in the scrape-off layer.

  14. Neoclassical offset toroidal velocity and auxiliary ion heating in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Lazzaro, E., E-mail: lazzaro@ifp.cnr.it [Istituto di Fisica del Plasma CNR (Italy)

    2016-05-15

    In conditions of ideal axisymmetry, for a magnetized plasma in a generic bounded domain, necessarily toroidal, the uniform absorption of external energy (e.g., RF or any isotropic auxiliary heating) cannot give rise to net forces or torques. Experimental evidence on contemporary tokamaks shows that the near central absorption of RF heating power (ICH and ECH) and current drive in presence of MHD activity drives a bulk plasma rotation in the co-I{sub p} direction, opposite to the initial one. Also the appearance of classical or neoclassical tearing modes provides a nonlinear magnetic braking that tends to clamp the rotation profile at the q-rational surfaces. The physical origin of the torque associated with P{sub RF} absorption could be due the effects of asymmetry in the equilibrium configuration or in power deposition, but here we point out also an effect of the response of the so-called neoclassical offset velocity to the power dependent heat flow increment. The neoclassical toroidal viscosity due to internal magnetic kink or tearing modes tends to relax the plasma rotation to this asymptotic speed, which in absence of auxiliary heating is of the order of the ion diamagnetic velocity. It can be shown by kinetic and fluid calculations, that the absorption of auxiliary power by ions modifies this offset proportionally to the injected power thereby forcing the plasma rotation in a direction opposite to the initial, to large values. The problem is discussed in the frame of the theoretical models of neoclassical toroidal viscosity.

  15. Rates of oxygen uptake increase independently of changes in heart rate in late stages of development and at hatching in the green iguana, Iguana iguana.

    Science.gov (United States)

    Sartori, Marina R; Abe, Augusto S; Crossley, Dane A; Taylor, Edwin W

    2017-03-01

    Oxygen consumption (VO 2 ), heart rate (f H ), heart mass (M h ) and body mass (M b ) were measured during embryonic incubation and in hatchlings of green iguana (Iguana iguana). Mean f H and VO 2 were unvarying in early stage embryos. VO 2 increased exponentially during the later stages of embryonic development, doubling by the end of incubation, while f H was constant, resulting in a 2.7-fold increase in oxygen pulse. Compared to late stage embryos, the mean inactive level of VO 2 in hatchlings was 1.7 fold higher, while f H was reduced by half resulting in a further 3.6 fold increase in oxygen pulse. There was an overall negative correlation between mean f H and VO 2 when data from hatchlings was included. Thus, predicting metabolic rate as VO 2 from measurements of f H is not possible in embryonic reptiles. Convective transport of oxygen to supply metabolism during embryonic incubation was more reliably indicated as an index of cardiac output (CO i ) derived from the product of f H and M h . However, a thorough analysis of factors determining rates of oxygen supply during development and eclosion in reptiles will require cannulation of blood vessels that proved impossible in the present study, to determine oxygen carrying capacity by the blood and arteriovenous oxygen content difference (A-V diff), plus patterns of blood flow. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Van Nuys, California. Limited Surface Observations Climatic Summary ’LISOCS.’ Parts A-F.

    Science.gov (United States)

    1987-08-04

    MONTH: JUL HOURS(LSI: 0600-39CO I WIND SPEE) TN KNOTS DIRECTION I 1-3 4 -6 i-10 121-16 17-2 1 22-??7 28- 33 34-4O NT1 -Ri 7 4-55 OF 56 TOTAL MEAN...NO CElL 1 89.1 9.1 54.6 55.7 S6.9 6.9 57.1 57.2 57.2 𔄁. 1. 1 97.3 57.! 97.3 51,’ 47.3 bE LOUCO 93.9 59.4 63.1 61.4 62.6 62.9 63.2 63.3 63...NO CElL I 77.: 47.4 5z.6 54.9 56.7 57.7 59.5 59.5 59.5 59.5 57.81 51 59.5 "q .5 59.5

  17. Influence of Immunology Knowledge on Healthcare and Healthy Lifestyle.

    Science.gov (United States)

    Abu Kassim, Noor Lide; Saleh Huddin, Afiqah Binti; Daoud, Jamal Ibrahim; Rahman, Mohammad Tariqur

    2016-01-01

    Completing a course in Immunology is expected to improve health care knowledge (HCK), which in turn is anticipated to influence a healthy lifestyle (HLS), controlled use of health care services (HCS) and an awareness of emerging health care concerns (HCC). This cross-sectional study was designed to determine whether these interrelationships are empirically supported. Participants involved in this study were government servants from two ministries in Malaysia (n = 356) and university students from a local university (n = 147). Participants were selected using the non-random purposive sampling method. Data were collected using a self-developed questionnaire, which had been validated in a pilot study involving similar subjects. The questionnaire items were analyzed using Rasch analysis, SPSS version 21 and AMOS version 22. Results have shown that participants who followed a course in Immunology (CoI) had a higher primary HCK (Mean = 0.69 logit, SD = 1.29 logits) compared with those who had not (Mean = -0.27logit, SD = 1.26 logits). Overall, there were significant correlations among the HLS, the awareness of emerging HCC, and the controlled use of HCS (p Immunology at various levels of education and increasing the public awareness of emerging HCC might help to improve population health en masse. In addition, further investigations on the factors affecting HLS is required to provide a better understanding on the relationship between primary HCK and HLS.

  18. Cardiac output and performance during a marathon race in middle-aged recreational runners.

    Science.gov (United States)

    Billat, Véronique L; Petot, Hélène; Landrain, Morgan; Meilland, Renaud; Koralsztein, Jean Pierre; Mille-Hamard, Laurence

    2012-01-01

    Despite the increasing popularity of marathon running, there are no data on the responses of stroke volume (SV) and cardiac output (CO) to exercise in this context. We sought to establish whether marathon performance is associated with the ability to sustain high fractional use of maximal SV and CO (i.e, cardiac endurance) and/or CO, per meter (i.e., cardiac cost). We measured the SV, heart rate (HR), CO, and running speed of 14 recreational runners in an incremental, maximal laboratory test and then during a real marathon race (mean performance: 3 hr 30 min ± 45 min). Our data revealed that HR, SV and CO were all in a high but submaximal steady state during the marathon (87.0 ± 1.6%, 77.2 ± 2.6%, and 68.7 ± 2.8% of maximal values, respectively). Marathon performance was inversely correlated with an upward drift in the CO/speed ratio (mL of CO × m(-1)) (r = -0.65, P marathon performance is inversely correlated with cardiac cost and positively correlated with cardiac endurance. The CO response could be a benchmark for race performance in recreational marathon runners.

  19. Moderately acurate oscillator strengths from NBS intensities

    International Nuclear Information System (INIS)

    Cowley, C.R.

    1983-01-01

    An earlier paper explored the calibration of NBS Monograph 145 intensity measurements for the purpose of obtaining useful oscillator strengths. In the present work we investigate the question of a single 'temperature' for the copper arc light sources. Statistical arguments support rejection of the null hypothesis of a single temperature. Evidence is found for a mild correction to the intensity scale, but there is no indication that the intensities drift with wave length. We reinforce earlier findings that very useful gf-values can be derived from Monograph 145 intensities for any spectrum in which there are enough accurate measurements for a calibration. For the present, it seems that such calibrations must be made individually for each spectrum, and the predictions should not be extrapolated beyond the calibration domains. A table lists interpolation coefficients for Fe I, Co I, Ni I, Ti I, Zr II, Y II, Nd II and U II. An improved formula is given to transform the Corliss-Tech Fe I oscillator strengths to the Oxford system. (author)

  20. Screen-Printed Carbon Electrodes Modified with Cobalt Phthalocyanine for Selective Sulfur Detection in Cosmetic Products

    Directory of Open Access Journals (Sweden)

    Ying Shih

    2011-06-01

    Full Text Available Cobalt phthalocyanine (CoPc films were deposited on the surface of a screen-printed carbon electrode using a simple drop coating method. The cyclic voltammogram of the resulting CoPc modified screen-printed electrode (CoPc/SPE prepared under optimum conditions shows a well-behaved redox couple due to the (CoI/CoII system. The CoPc/SPE surface demonstrates excellent electrochemical activity towards the oxidation of sulfur in a 0.01 mol·L−1 NaOH. A linear calibration curve with the detection limit (DL, S/N = 3 of 0.325 mg·L−1 was achieved by CoPc/SPE coupled with flow injection analysis of the sulfur concentration ranging from 4 to 1120 mg·L−1. The precision of the system response was evaluated (3.60% and 3.52% RSD for 12 repeated injections, in the range of 64 and 480 mg·L−1 sulfur. The applicability of the method was successfully demonstrated in a real sample analysis of sulfur in anti-acne creams, and good recovery was obtained. The CoPc/SPE displayed several advantages in sulfur determination including easy fabrication, high stability, and low cost.

  1. Synthesis and catalytic activity of N-heterocyclic silylene (NHSi) cobalt hydride for Kumada coupling reactions.

    Science.gov (United States)

    Qi, Xinghao; Sun, Hongjian; Li, Xiaoyan; Fuhr, Olaf; Fenske, Dieter

    2018-02-20

    The electron-rich silylene Co(i) chloride 5 was obtained through the reaction of CoCl(PMe 3 ) 3 with chlorosilylene. Complex 5 reacted with 1,3-siladiazole HSiMe(NCH 2 PPh 2 ) 2 C 6 H 4 to give the silylene Co(iii) hydride 6 through chelate-assisted Si-H activation. To the best of our knowledge, complex 6 is the first example of Co(iii) hydride supported by N-heterocyclic silylene. Complexes 5 and 6 were fully characterized by spectroscopic methods and X-ray diffraction analysis. Complex 6 was used as an efficient precatalyst for Kumada cross-coupling reactions. Compared with the related complex 3 supported by only trimethylphosphine, complex 6 as a catalyst supported by both chlorosilylene and trimethylphosphine exhibits a more efficient performance for the Kumada cross-coupling reactions. A novel catalytic radical mechanism was suggested and experimentally verified. As an intermediate silylene cobalt(ii) chloride 6d was isolated and structurally characterized.

  2. Plasma response to m/n  =  3/1 resonant magnetic perturbation at J-TEXT Tokamak

    Science.gov (United States)

    Hu, Qiming; Li, Jianchao; Wang, Nengchao; Yu, Q.; Chen, Jie; Cheng, Zhifeng; Chen, Zhipeng; Ding, Yonghua; Jin, Hai; Li, Da; Li, Mao; Liu, Yang; Rao, Bo; Zhu, Lizhi; Zhuang, Ge; the J-TEXT Team

    2016-09-01

    The influence of resonant magnetic perturbations (RMPs) with a large m/n  =  3/1 component on electron density has been studied at J-TEXT tokamak by using externally applied static and rotating RMPs, where m and n are the poloidal and toroidal mode number, respectively. The detailed time evolution of electron density profile, measured by the polarimeter-interferometer, shows that the electron density n e first increases (decreases) inside (around/outside) of the 3/1 rational surface (RS), and it is increased globally later together with enhanced edge recycling. Associated with field penetration, the toroidal rotation around the 3/1 RS is accelerated in the co-I p direction and the poloidal rotation is changed from the electron to ion diamagnetic drift direction. Spontaneous unlocking-penetration circles occur after field penetration if the RMPs amplitude is not strong enough. For sufficiently strong RMPs, the 2/1 locked mode is also triggered due to mode coupling, and the global density is increased. The field penetration threshold is found to be linearly proportional to n eL (line-integrated density) at the 3/1 RS but to (n eL)0.73 for n e at the plasma core. In addition, for rotating RMPs with a large 3/1 component, field penetration causes a global increase in electron density.

  3. GLOBULAR CLUSTER ABUNDANCES FROM HIGH-RESOLUTION, INTEGRATED-LIGHT SPECTROSCOPY. II. EXPANDING THE METALLICITY RANGE FOR OLD CLUSTERS AND UPDATED ANALYSIS TECHNIQUES

    Energy Technology Data Exchange (ETDEWEB)

    Colucci, Janet E.; Bernstein, Rebecca A.; McWilliam, Andrew [The Observatories of the Carnegie Institution for Science, 813 Santa Barbara St., Pasadena, CA 91101 (United States)

    2017-01-10

    We present abundances of globular clusters (GCs) in the Milky Way and Fornax from integrated-light (IL) spectra. Our goal is to evaluate the consistency of the IL analysis relative to standard abundance analysis for individual stars in those same clusters. This sample includes an updated analysis of seven clusters from our previous publications and results for five new clusters that expand the metallicity range over which our technique has been tested. We find that the [Fe/H] measured from IL spectra agrees to ∼0.1 dex for GCs with metallicities as high as [Fe/H] = −0.3, but the abundances measured for more metal-rich clusters may be underestimated. In addition we systematically evaluate the accuracy of abundance ratios, [X/Fe], for Na i, Mg i, Al i, Si i, Ca i, Ti i, Ti ii, Sc ii, V i, Cr i, Mn i, Co i, Ni i, Cu i, Y ii, Zr i, Ba ii, La ii, Nd ii, and Eu ii. The elements for which the IL analysis gives results that are most similar to analysis of individual stellar spectra are Fe i, Ca i, Si i, Ni i, and Ba ii. The elements that show the greatest differences include Mg i and Zr i. Some elements show good agreement only over a limited range in metallicity. More stellar abundance data in these clusters would enable more complete evaluation of the IL results for other important elements.

  4. Integrative approach revises the frequently misidentified species of Sardinella (Clupeidae) of the Indo-West Pacific Ocean.

    Science.gov (United States)

    Stern, N; Rinkevich, B; Goren, M

    2016-11-01

    To deal with the difficulties of species differentiation and delimitation among the commercially important sardines from the genus Sardinella, an integrative approach was adopted, incorporating traditional taxonomy with four DNA markers (coI, cytb, 16s and nuclear rag2). Combining these methodologies has enabled a thorough re-description of three of the most common species of Sardinella of the Indo-west Pacific Ocean: white sardinella Sardinella albella, fringescale sardinella Sardinella fimbriata and the goldstripe sardinella Sardinella gibbosa, as well as a description of a new species, Gon's sardinella Sardinella goni, from the island of Boracay, Philippines. In addition, extensive widespread sampling of S. gibbosa reveals a significant genetic separation between the populations from the western Indian Ocean and the west Pacific Ocean, despite no supporting morphological differentiation. An updated morphological key of the species of Sardinella of the Indo-west Pacific Ocean is also provided in order to minimize future misidentifications within these economically important taxa. Finally, the genetic and morphological variabilities within and between the investigated species are used to discuss their biogeographical distribution and possible processes of speciation. © 2016 The Fisheries Society of the British Isles.

  5. Retention of the metabolized trace elements in biological tissues following different drying procedures. I

    International Nuclear Information System (INIS)

    Iyengar, G.V.; Kasperek, K.; Feinendegen, L.E.

    1978-01-01

    Loss of Sb, Co, I, Hg, Se and Zn during freeze-drying and oven-drying at 80, 105 and 120 0 C were studied in rat tissues that contained metabolized radioactive isotopes. No loss was observed for any of the 6 elements on freeze-drying. However, tissue-specific differences were observed in many cases for Hg, Se, I and Sb on oven-drying. A significant loss of Hg was observed in liver even at 80 0 C, and for brain at 105 0 C. Se was lost from whole blood, brain, lung and muscle at 120 0 C, Sb was lost from whole blood at 105 0 C, but from brain, kidney, lung and spleen at 120 0 C. Iodine was also lost from whole blood, kidney, blood serum, erythrocytes, brain, lung and muscle at 120 0 C. Although the losses were statistically significant, they remained in most cases between 2 and 10% with the exception of Hg at 120 0 C, where the losses in some of the tissues were unpredictable. For urine, freeze-drying and oven-drying at 80 0 C was found to be relatively safe for Hg and I. At 105 0 C and above, serious loss of Hg was observed. In this experiment, the elements Zn, Co, Sb and Se were not studied for urine. (Auth

  6. Classification of X-ray spectra from laser produced plasmas of atoms from Tm to Pt in the range 6-9A

    International Nuclear Information System (INIS)

    Mandelbaum, P.; Klapisch, M.; Bar-Shalom, A.; Schwob, J.L.; Zigler, A.

    1983-01-01

    X-ray spectra of highly ionized tungsten and neighbouring atoms (Tm, Yb, Hf, Ta, W, Re and Pt) has been observed from laser produced plasmas in the lambda = 6-9A range. Beside the prominent lines of the Ni I-like ions, lines belonging to Co I (3d 9 -3d 8 4p), Cu I (3d 10 4s-3d 9 4s4p, 3d 10 4p-3d 9 4p 2 ) and Zn I-like ions (3d 10 4s 2 -3d 9 4s 2 4p, 3d 10 4s4p-3d 9 4s4p 2 ) have been identified. Classification was based on isoelectronic sequence analysis and on comparison with ab-initio relativistic calculations. A collisional-radiative model of the Cu I-like ions in the plasma is used to show that the contribution of the 3d 10 4d-3d 9 4p4d and 3d 10 4f-3d 9 4f4p transition arrays to the 3d-4p spectrum is small. The importance of configuration interaction is pointed out. Computations agree with measurements within experimental uncertainty. (Auth.)

  7. Magnetic and electronic properties of the Cu-substituted Weyl semimetal candidate ZrCo2Sn.

    Science.gov (United States)

    Kushwaha, S K; Wang, Zhijun; Kong, Tai; Cava, Robert

    2018-01-04

    We report that the partial substitution of Cu for Co has a significant impact on the magnetic properties of the Heusler-phase Weyl fermion candidate ZrCo2Sn. Polycrystalline samples of ZrCo2-xCuxSn (x = 0.0 to 1.0) exhibited a linearly decreasing ferromagnetic transition temperature and similarly decreasing saturated magnetic moment on increasing Cu substitution x. Materials with Cu contents near x = 1 and several other quaternary materials synthesized at the same x (ZrCo>T'Sn (T' = Rh, Pd, Ni)) display what appears to be non-ferromagnetic magnetization behavior with spin glass characteristics. Electronic structure calculations suggest that the half-metallic nature of unsubstituted ZrCo2Sn is disrupted significantly by the Cu substitutions, leading to the breakdown of the magnetization vs. electron count guidelines usually followed by Heusler phases, and a more typical metallic non-spin-polarized electronic structure at high x. © 2018 IOP Publishing Ltd.

  8. Strong Emergence as a Defese of Non-Reductive Physicalism

    Directory of Open Access Journals (Sweden)

    Carl Gillett

    2002-06-01

    Full Text Available Jaegwon Kim, and others, have recently posed a powerful challenge to both emergentism and nom-reductive physicalism by providing arguments that these positions are committed to an untenable combination of both ‘upward’ and ‘dounward’ determination. In section 1, I illuminate how the nature of the realization relation underlies such skeptical arguments However, in section 2, I suggest that such conclusions involve a confusion between the implications of physicalism and those of a related thesis the ‘Completeness of Physics' (Co? I show that the truth of CoP poses a very serious obstacle to realized properties being efficacious in a physicalist universe and suggest that abandoning CoP offers hope for defending non-reductive physicalism. I then formulate a schema for a physicalist metaphysics, in section 3, which rejects CoP. This scenario is one where microphysical properties have a few conditional powers that they contribute to individuals when they realize certain properties In such a situation, I argue, though physicalism holds true there is still plausibly both ‘upward’ and ‘downward’ determination, where the latter is crucially an underappreciated form of determination I temn 'non- causal'. Ultimately, I conclude that this metaphysical schema offers a coherent account of Strongly emergent properties that preserves the truth of NRP albeit, in a form that is purged of any commitment to CoP. Finally, in section: 4, I carefully explore which of Kim's assumptions and arguments this metaphysics undermines.

  9. Kinetics and mechanism of oxidation of super-reduced cobalamin and cobinamide species by thiosulfate, sulfite and dithionite.

    Science.gov (United States)

    Dereven'kov, Ilia A; Salnikov, Denis S; Makarov, Sergei V; Boss, Gerry R; Koifman, Oskar I

    2013-11-21

    We studied the kinetics of reactions of cob(I)alamin and cob(I)inamide with thiosulfate, sulfite, and dithionite by UV-Visible (UV-Vis) and stopped-flow spectroscopy. We found that the two Co(I) species were oxidized by these sulfur-containing compounds to Co(II) forms: oxidation by excess thiosulfate leads to penta-coordinate complexes and oxidation by excess sulfite or dithionite leads to hexa-coordinate Co(II)-SO2(-) complexes. The net scheme involves transfer of three electrons in the case of oxidation by thiosulfate and one electron for oxidation by sulfite and dithionite. On the basis of kinetic data, the nature of the reactive oxidants was suggested, i.e., HS2O3(-) (for oxidation by thiosulfate), S2O5(2-), HSO3(-), and aquated SO2 (for oxidation by sulfite), and S2O4(2-) and SO2(-) (for oxidation by dithionite). No difference was observed in kinetics with cob(i)alamin or cob(i)inamide as reductants.

  10. Molecular orbital study of the chemisorption of carbon monoxide on a tungsten (100) surface

    International Nuclear Information System (INIS)

    Lee, T.H.; Rabalais, J.W.

    1978-01-01

    The adsorption energies of carbon monoxide chemisorbed at various sites on a tungsten (100) surface have been calculated by extended Hueckel molecular orbital theory (EHMO). The concept of a 'surface molecule' in which CO is bonded to an array of tungsten atoms Wsub(n) has been employed. Dissociative adsorption in which C occupies a four-fold, five-coordination site and O occupies either a four- or two-fold site has been found to be the most stable form for CO on a W surface. Stable one-fold and two-fold sites of molecularly adsorbed CO have also been found in which the CO group is normal to the surface plane and the C atom is nearest the surface. Adsorption energies and molecular orbitals for the stable molecularly and dissociatively adsorbed CO sites are compared with the experimental data on various types of adsorbed CO, i.e. virgin-, α-, and β-CO. Models are suggested for each of these adsorption types. The strongest bonding interactions occur between the CO 5sigma orbital and the totally symmetric 5d and 6s orbitals of the Wsub(n) cluster. Possible mechanisms for conversion of molecularly adsorbed CO to dissociatively adsorbed CO are proposed and the corresponding activation energies are estimated. (Auth.)

  11. The Characteristics of Successful MOOCs in the Fields of Software, Science, and Management, According to Students’ Perception

    Directory of Open Access Journals (Sweden)

    Anat Cohen

    2016-12-01

    Full Text Available The characteristics of successful MOOCs were explored in this study. Thousands of student reviews regarding five xMOOCs (Massive Open Online Course in the fields of software, science, and management were extracted from the Coursetalk website and analyzed by quantitative and qualitative methods using the Garrison, Anderson, and Archer (2000 Community of Inquiry (CoI model. The 14 characteristics found to contribute to the success of MOOCs (e.g., teacher, atmosphere, exercise were partitioned into the teaching, social, and cognitive presence elements. In addition, cluster analysis revealed five types of learners, based on the characteristics they mentioned for course success: atmosphere, exercise, teacher, exam, and unspecified. This divides learners into groups that may prefer social, cognitive, or teaching presence. The findings of this study negate the perception that xMOOCs mostly contain teaching presence elements. This research contributes to the understanding of characteristics that contribute to successful MOOCs and sheds light on the students, too. Listening to the voices of the students and the types of characteristics that they chose to mention, enables further exploration of their preferences and expectations regarding MOOCs and, accordingly, to future adaptation between students’ preferences and MOOC characteristics.

  12. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 6 (Colson Equipment Inc-Delta Engineering Inc)

    Science.gov (United States)

    1990-01-01

    4NN cow -i =0 an 0 10 fta e ~ fw w w 0-4N a NaL00N0 nop-- N- Do 00) (0 00 (0 ft - 4. = 4N0 a Vtfttf. fftfftfttfVftfft v . ,C)e)mmmmV V)f ft co0 ft ft...4 i N CNNNN N * 0 Oft Kx 0C 0 0C 44 C -cc0 44 4C *ON W W 0 A 0C K U3-4 :oz 02 02 0-’- 0- 0)- 0- 02z 0) - 0---- 0)- K c) : M.f K fta ftI 0M 0 Mt 0 ft... FMD MIo 4 0c U010- L. to P I -- N-4 to 140 w Mc-I. .0-4- .- 4-II-a-4 ccI Co .-I -40 am U 0 I M0 Rr a 0 0 0n~n~ 000w4 n InnOf~n~ 00 00 0- M C C U I

  13. Reduction reactions of water soluble cyano-cobalt(III)-porphyrins: Metal versus ligand centered processes

    International Nuclear Information System (INIS)

    Mosseri, S.; Neta, P.; Harriman, A.; Hambright, P.

    1990-01-01

    Reduction reactions of dicyano-cobalt(III)-porphyrins [potential in vivo cyanide scavenger drugs] were studied by radiolytic and electrochemical methods using the water soluble tetrakis(4-sulfonatophenyl)porphyrin (TPPS) and tetrakis(N-methyl-4-pyridyl)porphyrin (TMPyP). For [(CN)2CoIIITPPS]-, reduction occurs stepwise to the CoII, CoI, and finally to the phlorin anion. This behavior is similar to that of the cobalt porphyrins in the absence of cyanide, except that the cyanide ligand shifts the reduction potentials to much more negative values. On the other hand, under radiolytic conditions, [(CN)2CoIIITMPyP]- is reduced on the porphyrin macrocycle by one electron to give the CoIII pi-radical anion, which disproportionates into the initial complex and the two-electron ring reduced CoIII phlorin. The radical anion is also formed by intramolecular electron transfer subsequent to the reaction of CoIITMPyP and cyanide. The results are compared with the chemistry of Vitamin B-12

  14. Multiple Convergent Origins of Workerlessness and Inbreeding in the Socially Parasitic Ant Genus Myrmoxenus.

    Science.gov (United States)

    Heinze, Jürgen; Buschinger, Alfred; Poettinger, Theo; Suefuji, Masaki

    2015-01-01

    The socially parasitic ant genus Myrmoxenus varies strongly in fundamental life history traits, such as queen-worker ratio, the timing of sexual production, and mating behavior. Myrmoxenus queens generally take over nests of Temnothorax ants, kill the resident queen by throttling, and force the workers to take care of the social parasite's brood. Young queens of M. ravouxi and other species produce large numbers of workers, which during "slave-raids" pillage host pupae from neighboring Temnothorax colonies to increase the workforce in their own nests. Other species, such as M. corsicus, have lost caste polyphenism and rear only male and female sexual offspring. Using sequences of the genes CO I/CO II and wingless we reconstruct the phylogeny of Myrmoxenus and document that the worker caste was lost convergently at least three times. Furthermore, mating in the nest and inbreeding obviously also evolved in parallel from ancestors whose sexuals presumably mated during nuptial flights. Myrmoxenus might thus provide a suitable model to investigate caste differentiation and the plasticity of mating behavior in Hymenoptera.

  15. Dollar Summary of Prime Contract Awards by State, Place and Contractor, FY 85. Part 1 (Alexandria, Alabama - Yorkville, Illinois.

    Science.gov (United States)

    1985-01-01

    m - zago zi 9zs 0 m U)l 4c140 0 "< z( . 40 21 I z)-0 "o 0 W 0 >W~ zl "I 00 (04It06 lN t04 01 U (i C0...IU I. In 4c * NO a 05 ’ 44 E - I I A 0 CO I q~o c N M inI5V F z I. I. . .- 01 I- 0. 0 -1Nc4 .4 CL C N- (ogo - C- z I.- w R a. A0 w . z 0 0-I" 14.$A I9...a.n GoCV)t-0 a C1 m n m ’ I. CVI CV in OD) N C) 4 0 ~ ~~ a . r a O aca 40 Z au ’ FJ.. *.4hmN 0- I : N 1 04 1 I. *c’ a-J a 00C)r P oI 4 a . 9 -4 .a a

  16. MO-Co@N-Doped Carbon (M = Zn or Co): Vital Roles of Inactive Zn and Highly Efficient Activity toward Oxygen Reduction/Evolution Reactions for Rechargeable Zn-Air Battery

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Biaohua [State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029 P. R. China; Beijing Key Laboratory of Energy Environmental Catalysis, Beijing University of Chemical Technology, Beijing 100029 P. R. China; He, Xiaobo [Changzhou Institute of Advanced Materials, Beijing University of Chemical Technology, Changzhou 213164 P. R. China; Yin, Fengxiang [State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029 P. R. China; Beijing Key Laboratory of Energy Environmental Catalysis, Beijing University of Chemical Technology, Beijing 100029 P. R. China; Changzhou Institute of Advanced Materials, Beijing University of Chemical Technology, Changzhou 213164 P. R. China; Wang, Hao [State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029 P. R. China; Beijing Key Laboratory of Energy Environmental Catalysis, Beijing University of Chemical Technology, Beijing 100029 P. R. China; Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne IL 60439 USA; Liu, Di-Jia [Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne IL 60439 USA; Shi, Ruixing [State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029 P. R. China; Chen, Jinnan [State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029 P. R. China; Yin, Hongwei [State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029 P. R. China

    2017-06-14

    A highly efficient bifunctional oxygen catalyst is required for practical applications of fuel cells and metal-air batteries, as oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are their core electrode reactions. Here, the MO-Co@ N-doped carbon (NC, M = Zn or Co) is developed as a highly active ORR/OER bifunctional catalyst via pyrolysis of a bimetal metal-organic framework containing Zn and Co, i.e., precursor (CoZn). The vital roles of inactive Zn in developing highly active bifunctional oxygen catalysts are unraveled. When the precursors include Zn, the surface contents of pyridinic N for ORR and the surface contents of Co-N-x and Co3+/Co2+ ratios for OER are enhanced, while the high specific surface areas, high porosity, and high electrochemical active surface areas are also achieved. Furthermore, the synergistic effects between Zn-based and Co-based species can promote the well growth of multiwalled carbon nanotubes (MWCNTs) at high pyrolysis temperatures (>= 700 degrees C), which is favorable for charge transfer. The optimized CoZn-NC-700 shows the highly bifunctional ORR/OER activity and the excellent durability during the ORR/OER processes, even better than 20 wt% Pt/C (for ORR) and IrO2 (for OER). CoZn-NC-700 also exhibits the prominent Zn-air battery performance and even outperforms the mixture of 20 wt% Pt/C and IrO2.

  17. Molecular Identification and Genetic Diversity of Acropora hyacinthus from Boo and Deer Island, Raja Ampat, West Papua

    Science.gov (United States)

    Wijayanti, DP; Indrayanti, E.; Nuryadi, H.; Dewi, RA; Sabdono, A.

    2018-02-01

    Indonesia lies at the centre of biodiversity for corals. However, the reefs suffered from extensive human exploitation. Marine Protected Areas is thought to be best solution to protect coral reefs ecosystem. Understanding genetic diversity is crucial for effective management of the MPAs, however genetic diversity is rarely been corporate in designing an MPA. Moreover, many MPAs are uneffectively manage due to poor designated and demarcated.Raja Ampat which is located in western tip of West Papua, was designated as a park to mitigatethreatsand protect the valuable marine resources.Scleractinian corals in the genus Acropora are among the most dominant distributed in Raja Ampat waters, including the species of Acroporahyacinthus. The research aimed to analyze genetic diversity and to describe the kinship relationship of Acroporahyacinthus between 2 populations: Boo Island and Deer Island, Raja Ampat. Genetic marker Cytochrome Oxidase I (CO I) of the mitochondrial genome DNA (mtDNA) was used to analyze genetic diversity. Reconstruction of phylogenetic tree and genetic diversity were made by usingsoftware MEGA 5.05 (Moleculer Evolutionary Genetics Analysis). The results of this research indicatecorals A. hyacinthus from Boo Island and Deer Island Raja Ampat are in the low category of genetic diversity and overall had a close genetic relationship of kinship. This is likely due to the small size of the population and few numbers of samples that may not represent the population.

  18. [Applylication of new type combined fragments: nrDNA ITS+ nad 1-intron 2 for identification of Dendrobium species of Fengdous].

    Science.gov (United States)

    Geng, Li-xia; Zheng, Rui; Ren, Jie; Niu, Zhi-tao; Sun, Yu-long; Xue, Qing-yun; Liu, Wei; Ding, Xiao-yu

    2015-08-01

    In this study, 17 kinds of Dendrobium species of Fengdous including 39 individuals were collected from 4 provinces. Mitochondrial gene sequences co I, nad 5, nad 1-intron 2 and chloroplast gene sequences rbcL, matK amd psbA-trnH were amplified from these materials, as well as nrDNA ITS. Furthermore, suitable sequences for identification of Dendrobium species of Fengdous were screened by K-2-P and P-distance. The results showed that during the mentioned 7 sequences, nrDNA ITS, nad 1-intron 2 and psbA-trnH which had a high degree of variability could be used to identify Dendrobium species of Fengdous. However, single fragment could not be used to distinguish D. moniliforme and D. huoshanense. Moreover, compared to other combined fragments, new type combined fragments nrDNA ITS+nad 1-intron 2 was more effective in identifying the original plants of Dendrobium species and could be used to identify D. huoshanense and D. moniliforme. Besides, according to the UPGMA tree constructed with nrDNA ITS+nad 1-intron 2, 3 inspected Dendrobium plants were identified as D. huoshanense, D. moniliforme and D. officinale, respectively. This study identified Dendrobium species of Fengdous by combined fragments nrDNA ITS+nad 1-intron 2 for the first time, which provided a more effective basis for identification of Dendrobium species. And this study will be helpful for regulating the market of Fengdous.

  19. Multiple Convergent Origins of Workerlessness and Inbreeding in the Socially Parasitic Ant Genus Myrmoxenus.

    Directory of Open Access Journals (Sweden)

    Jürgen Heinze

    Full Text Available The socially parasitic ant genus Myrmoxenus varies strongly in fundamental life history traits, such as queen-worker ratio, the timing of sexual production, and mating behavior. Myrmoxenus queens generally take over nests of Temnothorax ants, kill the resident queen by throttling, and force the workers to take care of the social parasite's brood. Young queens of M. ravouxi and other species produce large numbers of workers, which during "slave-raids" pillage host pupae from neighboring Temnothorax colonies to increase the workforce in their own nests. Other species, such as M. corsicus, have lost caste polyphenism and rear only male and female sexual offspring. Using sequences of the genes CO I/CO II and wingless we reconstruct the phylogeny of Myrmoxenus and document that the worker caste was lost convergently at least three times. Furthermore, mating in the nest and inbreeding obviously also evolved in parallel from ancestors whose sexuals presumably mated during nuptial flights. Myrmoxenus might thus provide a suitable model to investigate caste differentiation and the plasticity of mating behavior in Hymenoptera.

  20. A cell clone strain from Mythimna separata (Lepidoptera: Noctuidae) highly susceptible to Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and M. separata NPV (MsNPV).

    Science.gov (United States)

    Meng, Xiang-Qian; Zheng, Gui-Ling; Zhao, Chuan-De; Wan, Fang-Hao; Li, Chang-You

    2017-08-01

    In this study, we describe a cell line, Ms-10C, cloned from the line QAU-Ms-E-10 (simplified Ms-10), an embryonic line from Mythimna separata. The cloned cell line was significantly more sensitive to nucleopolyhedrovirus (NPV). Ms-10C cells were mainly spherical with a diameter of 14.42 ± 2.23 μm. DNA amplification fingerprinting (DAF) confirmed the profile of PCR-amplified bands of the cloned cell line was consistent with those of the parental cell line, Ms-10. The sequencing result of the mitochondrial cytochrome c oxidase I (mtCO I) fragment confirmed that the amplified 636-bps mtCOI fragment was 100% identical to that of M. separata. Its chromosomes exhibited the typical characters of lepidopteran cell lines. Its population doubling time was 42.2 h at 27°C. Ms-10C was more sensitive than Ms-10 to both Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and M. separata nucleopolyhedrovirus (MsNPV). At 4 d post infection, the infection rates of two viruses reached 94.2 and 92.3%, respectively. The availability of this cell clone strain will provide a useful tool for the basic research on nucleopolyhedrovirus and for potential application in expression of recombinant proteins with baculovirus expression vector system.

  1. Glass-Forming Ability and Early Crystallization Kinetics of Novel Cu-Zr-Al-Co Bulk Metallic Glasses

    Directory of Open Access Journals (Sweden)

    Xiaoliang Han

    2016-09-01

    Full Text Available In recent years, CuZr-based bulk metallic glass (BMG composites ductilized by a shape memory B2 CuZr phase have attracted great attention owing to their outstanding mechanical properties. However, the B2 CuZr phase for most CuZr-based glass-forming compositions is only stable at very high temperatures, leading to the uncontrollable formation of B2 crystals during quenching. In this work, by introducing Co (i.e., 4, 5, and 6 at. % and 10 at. % Al into CuZr-based alloys, the relatively good glass-forming ability (GFA of CuZr-based alloys still can be achieved. Meanwhile, the B2 phase can be successfully stabilized to lower temperatures than the final temperatures of crystallization upon heating CuZr-based BMGs. Unlike previous reported CuZr-based BMGs, the primary crystallization products upon heating are mainly B2 CuZr crystals but not CuZr2 and Cu10Zr7 crystals. Furthermore, the primary precipitates during solidification are still dominated by B2 crystals, whose percolation threshold is detected to lie between 10 ± 2 vol. % and 31 ± 2 vol. %. The crystallization kinetics underlying the precipitation of B2 crystals was also investigated. Our results show that the present glass-forming composites are promising candidates for the fabrication of ductile CuZr-based BMG composites.

  2. Homogeneous Photodynamical Analysis of Kepler's Multiply-Transiting Systems

    Science.gov (United States)

    Ragozzine, Darin

    . Research Objective 1 (RO1) Gather and detrend publicly-available light curves for Kepler MTSs; gather starting guesses of preliminary planetary and stellar parameters from the Kepler pipeline (e.g., Rowe et al. 2014) and other studies; and expand our existing photodynamical code (e.g., Mills & Fabrycky 2017) to handle all Kepler MTSs. All required data are publicly available and our significant past expertise demonstrates our ability to complete these tasks. The new photodynamical code will be called the PhotoDynamical Multi-planet Model (PhoDyMM) and described in a paper. Research Objective 2 (RO2) Apply PhoDyMM to the 600 known systems with 2-3 transiting planets; publish these results, including full posterior distributions for all systems (to be housed at the NASA Exoplanet Archive). Research Objective 3 (RO3) Apply PhoDyMM to the 100 Kepler MTSs with 4 or more planets. This astrophysics data analysis is a major step beyond existing efforts and will provide the definitive physical and orbital properties for Kepler MTSs. It is clearly responsive to the Astrophysics Data Analysis Program and relevant to NASA Astrophysics Goals. PI Ragozzine and Co-I Fabrycky have participated in the Kepler prime science mission since its inception and have significant experience in all required areas. Co-I Mills has the most published uses of a photodynamical model on some of the most difficult to analyze exoplanetary systems (Kepler-11, Kepler-108 Kepler-223, Kepler-444). We will employ best practices for Data Management such as archiving posterior distributions and providing open access to PhoDyMM. PI Ragozzine s startup provided sufficient computational resources to perform the extensive analyses. He will be supported by a graduate student and unfunded undergraduates.

  3. Intractable secretory diarrhea in a Japanese boy with mitochondrial respiratory chain complex I deficiency.

    Science.gov (United States)

    Murayama, Kei; Nagasaka, Hironori; Tsuruoka, Tomoko; Omata, Yuko; Horie, Hiroshi; Tregoning, Simone; Thorburn, David R; Takayanagi, Masaki; Ohtake, Akira

    2009-03-01

    The etiology of secretory diarrhea in early life is often unclear. We report a Japanese boy who survived until 3 years of age, despite intractable diarrhea commencing soon after birth. The fecal sodium content was strikingly high (109 mmol/L [normal range, 27-35 mmol/L]) and the osmotic gap was decreased (15 mOsm/kg), consistent with the findings of congenital sodium diarrhea. We examined the mitochondrial respiratory chain function by blue native polyacrylamide gel electrophoresis (BN-PAGE) in-gel enzyme staining, BN-PAGE western blotting, respiratory chain enzyme activity assay, and immunohistochemistry. Liver respiratory chain complex (Co) I activity was undetectable, while other respiratory chain complex activities were increased (Co II, 138%; Co III, 153%; Co IV, 126% versus respective control activities). Liver BN-PAGE in-gel enzyme staining and western blotting showed an extremely weak complex I band, while immunohistochemistry showed extremely weak staining for the 30-kDa subunit of complex I, but normal staining for the 70-kDa subunit of complex II. The patient was, therefore, diagnosed with complex I deficiency. The overall complex I activity of the jejunum was substantially decreased (63% of the control activity). The immunohistochemistry displayed apparently decreased staining of the 30-kDa complex I subunit, together with a slightly enhanced staining of the 70-kDa complex II subunit in intestinal epithelial cells. These data imply that intestinal epithelial cells are also complex I-deficient in this patient. Complex I deficiency is a novel cause of secretory diarrhea and may act via disrupting the supply of adenosine triphosphate (ATP) needed for the maintenance of ion gradients across membranes.

  4. Trace elements in the alimentary tract of Svalbard reindeer

    Directory of Open Access Journals (Sweden)

    Hans Staaland

    1985-05-01

    Full Text Available In the alimentary tract of Svalbard reindeer concentrations of Fe and Co were higher in winter than in summer, whereas the concentrations of Mn and Cu were equal in both seasons. Zn concentrations were higher in summer throughout the alimentary tract, but Mo were highest only in the distal part. The general pattern of absorption in the alimentary tract seems to correspond to findings in other ruminants. The very high levels of Fe and Co are emphasized.Sporelementer i fordøyelseskanalen hos Svalbard-rein.Abstract in Norwegian / Sammendrag: Konsentrasjonen av Fe og Co i fordøyelsessystemet hos Svalbard-rein var høyere om vinteren enn om sommeren, mens konsentrasjonene av Mn og Cu var like vinter og sommer. Zn konsentrasjonene var høyest om sommeren gjennom hele fordøyelsessystemet, mens Mo konsentrasjonene var høyest i det distale avsnittet. Det generelle absorbsjonsmønster synes å stemme overens med funn fra andre drøvtyggere. De svært høye nivåer av Fe og Co blir fremhevet.Huippuvuorten peuran ruoansulatuskanavan ilmaisijaelementeistå.Abstract in Finnish / Yhteenveto: Huippuvuorten peuran ruoansulatuskanavassa mitattiin talvella korkeammat Fe- ja Co-pitoisuudet kuin kesalla, kun taas Mn- ja Cu-pitoisuudet olivat samanlaisia kesålla ja talvella. Zn-pitoisuudet olivat korkeimmillaan kesållå koko ruoansulatuskanavassa, kun taas Mo-pitoisuudet olivat korkeimmat kanavan distaaliosassa. Yleinen absorptiomalli nayttaa hyvin sopivan yhteen muilla mårehtijoilla tehtyjen loydosten kanssa. Tutkimuksessa korostetaan raudan ja koboltin erityisen korkeaa tasoa.

  5. Chlorine isotope effects from isotope ratio mass spectrometry suggest intramolecular C-Cl bond competition in trichloroethene (TCE) reductive dehalogenation.

    Science.gov (United States)

    Cretnik, Stefan; Bernstein, Anat; Shouakar-Stash, Orfan; Löffler, Frank; Elsner, Martin

    2014-05-20

    Chlorinated ethenes are prevalent groundwater contaminants. To better constrain (bio)chemical reaction mechanisms of reductive dechlorination, the position-specificity of reductive trichloroethene (TCE) dehalogenation was investigated. Selective biotransformation reactions (i) of tetrachloroethene (PCE) to TCE in cultures of Desulfitobacterium sp. strain Viet1; and (ii) of TCE to cis-1,2-dichloroethene (cis-DCE) in cultures of Geobacter lovleyi strain SZ were investigated. Compound-average carbon isotope effects were -19.0‰ ± 0.9‰ (PCE) and -12.2‰ ± 1.0‰ (TCE) (95% confidence intervals). Using instrumental advances in chlorine isotope analysis by continuous flow isotope ratio mass spectrometry, compound-average chorine isotope effects were measured for PCE (-5.0‰ ± 0.1‰) and TCE (-3.6‰ ± 0.2‰). In addition, position-specific kinetic chlorine isotope effects were determined from fits of reactant and product isotope ratios. In PCE biodegradation, primary chlorine isotope effects were substantially larger (by -16.3‰ ± 1.4‰ (standard error)) than secondary. In TCE biodegradation, in contrast, the product cis-DCE reflected an average isotope effect of -2.4‰ ± 0.3‰ and the product chloride an isotope effect of -6.5‰ ± 2.5‰, in the original positions of TCE from which the products were formed (95% confidence intervals). A greater difference would be expected for a position-specific reaction (chloride would exclusively reflect a primary isotope effect). These results therefore suggest that both vicinal chlorine substituents of TCE were reactive (intramolecular competition). This finding puts new constraints on mechanistic scenarios and favours either nucleophilic addition by Co(I) or single electron transfer as reductive dehalogenation mechanisms.

  6. Optimization of amino acid type-specific 13C and 15N labeling for the backbone assignment of membrane proteins by solution- and solid-state NMR with the UPLABEL algorithm

    International Nuclear Information System (INIS)

    Hefke, Frederik; Bagaria, Anurag; Reckel, Sina; Ullrich, Sandra Johanna; Dötsch, Volker; Glaubitz, Clemens; Güntert, Peter

    2011-01-01

    We present a computational method for finding optimal labeling patterns for the backbone assignment of membrane proteins and other large proteins that cannot be assigned by conventional strategies. Following the approach of Kainosho and Tsuji (Biochemistry 21:6273–6279 (1982)), types of amino acids are labeled with 13 C or/and 15 N such that cross peaks between 13 CO(i – 1) and 15 NH(i) result only for pairs of sequentially adjacent amino acids of which the first is labeled with 13 C and the second with 15 N. In this way, unambiguous sequence-specific assignments can be obtained for unique pairs of amino acids that occur exactly once in the sequence of the protein. To be practical, it is crucial to limit the number of differently labeled protein samples that have to be prepared while obtaining an optimal extent of labeled unique amino acid pairs. Our computer algorithm UPLABEL for optimal unique pair labeling, implemented in the program CYANA and in a standalone program, and also available through a web portal, uses combinatorial optimization to find for a given amino acid sequence labeling patterns that maximize the number of unique pair assignments with a minimal number of differently labeled protein samples. Various auxiliary conditions, including labeled amino acid availability and price, previously known partial assignments, and sequence regions of particular interest can be taken into account when determining optimal amino acid type-specific labeling patterns. The method is illustrated for the assignment of the human G-protein coupled receptor bradykinin B2 (B 2 R) and applied as a starting point for the backbone assignment of the membrane protein proteorhodopsin.

  7. MO-DE-202-02: Advances in Image Registration and Reconstruction for Image-Guided Neurosurgery

    Energy Technology Data Exchange (ETDEWEB)

    Siewerdsen, J. [Johns Hopkins University (United States)

    2016-06-15

    Disclosure and CoI: IGI Technologies, small-business partner on the grants.

  8. MO-DE-202-01: Image-Guided Focused Ultrasound Surgery and Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Farahani, K. [National Cancer Institute (United States)

    2016-06-15

    Disclosure and CoI: IGI Technologies, small-business partner on the grants.

  9. MO-DE-202-04: Multimodality Image-Guided Surgery and Intervention: For the Rest of Us

    Energy Technology Data Exchange (ETDEWEB)

    Shekhar, R. [Children’s National Health System (United States)

    2016-06-15

    Disclosure and CoI: IGI Technologies, small-business partner on the grants.

  10. MO-DE-202-00: Image-Guided Interventions: Advances in Intraoperative Imaging, Guidance, and An Emerging Role for Medical Physics in Surgery

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-06-15

    Disclosure and CoI: IGI Technologies, small-business partner on the grants.

  11. MO-DE-202-03: Image-Guided Surgery and Interventions in the Advanced Multimodality Image-Guided Operating (AMIGO) Suite

    Energy Technology Data Exchange (ETDEWEB)

    Kapur, T. [Brigham & Women’s Hospital (United States)

    2016-06-15

    Disclosure and CoI: IGI Technologies, small-business partner on the grants.

  12. More SPECTRA! a Lot MORE! Better TOO! now What?

    Science.gov (United States)

    Field, Robert W.

    2017-06-01

    I have been a card-carrying spectroscopist for 52 years. I began my career studying spectroscopic perturbations in CS and CO. I eventually graduated to vibrational polyads in acetylene and Multichannel Quantum Defect Theory (MQDT) models for Rydberg states of CaF. My experimental arsenal evolved from atomic resonance lamps to finicky cw dye lasers to user-friendly Nd:YAG pumped dye lasers, ending up with Chirped Pulse Millimeter Waves, non-finicky solid state cw lasers, and death-defying dreams about Stimulated Raman Adiabatic Passage (STIRAP). It has become possible to record an enormous quantity of unimaginably high quality spectra quickly. Increases by factors of 10^{6} in spectral velocity have been claimed. Yet everything rests on assigning the spectrum. But the assignment game has changed. Instead of looking for patterns, we deal with meta-patterns. Our goal is to build a complex model that represents all of the energy levels and associates a multi-component eigenvector with each observed eigenstate. Eigenvectors can reveal what a molecule is thinking about doing when it grows up. Spectroscopy becomes a form of molecular psychoanalysis. A spectroscopist can observe the emergence and describe the mechanistic origin of new classes of large-amplitude intramolecular motions. This makes it possible to directly characterize things, such as transition states, which dogma has labeled "spectroscopically unobservable." Where is 21st century spectroscopy headed? I will discuss examples that include: spectroscopic perturbations of the S_{2} B^{3}Σ^{-}_{u} state, the SO_{2} C state with its unequal SO bond-lengths, and the transition state for trans-cis isomerization in the S_{1} state of acetylene.

  13. Uptake by benthic algae of critical radionuclides to be released in the liquid effluent of the Angra dos Reis Nuclear Power Plant, R.J., Brazil

    International Nuclear Information System (INIS)

    Guimaraes, J.R.D.

    1982-06-01

    In vitro interaction of benthic algae from the Angra dos Reis region, R.J., Brazil, was studied with critical radionuclides to be released in the liquid effluent of CNAAA (unit I). 137 Cs- 60 Co - and 125 I uptake and loss by Sargassum filipendula, Padina Vickersiae and Acanthophora Spicifera were observed. Biological half-lives and bioaccumulation factors (B.F.) were estimated. Co and I uptake were fast (apparent equilibrium in 3 to 7 days). Cs uptake was slower (2 to 3 weeks). Loss followed an inverse pattern (fast for Cs, slow for Co and I). B.F. ranged from 10 1 for Cs, to 10 3 for I and 10 3 -10 4 for Co. Higher B.F. for Co and I were found for P. vickersiae (up to 1,4 X 10 4 ) an A. spicifera (up to 7 X 10 3 ) respectively. These species represent important potential media for the transference of Co-I-and-to a much lesser extent - Cs isotopes, through food-webs. They exhibited high capacity to compete with local sandy sediments for the retention of Co and I. High B.F., rapid uptake and moderate to long biological half-lives enable S. filipendula, P. vickersiae and A. specifera to be powerful aids in the monitoring of radioactive contamination by Co and I isotopes. Since the majority of marine organisms tends to exhibit Cs B.F. similars to those reported here, these algae may also be used as monitors for Cs isotopes, the low B.F. being compensated by their abundance, wide distribution and facility of collection. (M.A.) [pt

  14. [Sequencing of mitochondrial DNA cytochrome oxidase subunit I gene in sarcosaphagous flies from 14 provinces in China].

    Science.gov (United States)

    Yang, Li; Cai, Jifeng; Wen, Jifang; Guo, Yadong

    2010-08-01

    Boettcherisca peregrine (Robineau-Desvoidy)]. The genus of the sarcosaphagous flies can be identified by 278 bp gene sequence analysis of CO I in mtDNA. This method is rapid, convenient and precise.

  15. Goldstone Radar Observations of the 1999 Mars Opposition and other Observing Opportunities

    Science.gov (United States)

    Slade, M. A.

    1997-07-01

    As part of the International Mars Watch, Goldstone radar observations of Mars are planned during the 1999 Opposition ( Feb.'99-Aug'99). While some observing time is already allocated, a number of tracks could be made available for well-focused scientific objectives. Since the Deep Space Network plans far in advance, now is the time to develop your plans. During the next Mars opposition, the sub-Earth latitudes are in Mars' Northern hemisphere over the most northerly terrain accessible, which has not been previously examined with current sensitivity. The North residual ice cap is of particular interest. As a reminder to the Planetary Science community, observing proposals from any scientist with peer-reviewed planetary funding are solicited and should be forwarded to Martin.A.Slade@jpl.nasa.gov by email. Data reduction can, in principle, be carried out over the Internet. A graduate student or postdoctoral fellow resident at JPL for short period is recommended, however, to become familiar with suite of software for data analysis. Unfortunately, JPL cannot guarantee travel reimbursement due to funding limitations. We urge your consideration of becoming involved with the acquisition and analysis of Goldstone radar data. In the recent past, P.I.'s or co-I.s from Cornell, Arecibo/NAIC, Washington State University, Univ. Cal. Berkeley, Harvard -Smithsonian Center for Astrophysics, Univ. of Chicago, the DLR, Kashima SRC, ISAS, the Russian Academy of Science, the Russian Space Agency, and the USGS, have participated in radar experiments with Goldstone transmitting. This work is supported by the California Institute of Technology, under contract with NASA.

  16. Cardiac Output and Performance during a Marathon Race in Middle-Aged Recreational Runners

    Directory of Open Access Journals (Sweden)

    Véronique L. Billat

    2012-01-01

    Full Text Available Purpose. Despite the increasing popularity of marathon running, there are no data on the responses of stroke volume (SV and cardiac output (CO to exercise in this context. We sought to establish whether marathon performance is associated with the ability to sustain high fractional use of maximal SV and CO (i.e, cardiac endurance and/or CO, per meter (i.e., cardiac cost. Methods. We measured the SV, heart rate (HR, CO, and running speed of 14 recreational runners in an incremental, maximal laboratory test and then during a real marathon race (mean performance: 3 hr 30 min ± 45 min. Results. Our data revealed that HR, SV and CO were all in a high but submaximal steady state during the marathon (87.0 ± 1.6%, 77.2 ± 2.6%, and 68.7 ± 2.8% of maximal values, respectively. Marathon performance was inversely correlated with an upward drift in the CO/speed ratio (mL of CO×m−1 (r=−0.65, P<0.01 and positively correlated with the runner’s ability to complete the race at a high percentage of the speed at maximal SV (r=0.83, P<0.0002. Conclusion. Our results showed that marathon performance is inversely correlated with cardiac cost and positively correlated with cardiac endurance. The CO response could be a benchmark for race performance in recreational marathon runners.

  17. Chlorine Isotope Effects from Isotope Ratio Mass Spectrometry Suggest Intramolecular C-Cl Bond Competition in Trichloroethene (TCE Reductive Dehalogenation

    Directory of Open Access Journals (Sweden)

    Stefan Cretnik

    2014-05-01

    Full Text Available Chlorinated ethenes are prevalent groundwater contaminants. To better constrain (biochemical reaction mechanisms of reductive dechlorination, the position-specificity of reductive trichloroethene (TCE dehalogenation was investigated. Selective biotransformation reactions (i of tetrachloroethene (PCE to TCE in cultures of Desulfitobacterium sp. strain Viet1; and (ii of TCE to cis-1,2-dichloroethene (cis-DCE in cultures of Geobacter lovleyi strain SZ were investigated. Compound-average carbon isotope effects were −19.0‰ ± 0.9‰ (PCE and −12.2‰ ± 1.0‰ (TCE (95% confidence intervals. Using instrumental advances in chlorine isotope analysis by continuous flow isotope ratio mass spectrometry, compound-average chorine isotope effects were measured for PCE (−5.0‰ ± 0.1‰ and TCE (−3.6‰ ± 0.2‰. In addition, position-specific kinetic chlorine isotope effects were determined from fits of reactant and product isotope ratios. In PCE biodegradation, primary chlorine isotope effects were substantially larger (by −16.3‰ ± 1.4‰ (standard error than secondary. In TCE biodegradation, in contrast, the product cis-DCE reflected an average isotope effect of −2.4‰ ± 0.3‰ and the product chloride an isotope effect of −6.5‰ ± 2.5‰, in the original positions of TCE from which the products were formed (95% confidence intervals. A greater difference would be expected for a position-specific reaction (chloride would exclusively reflect a primary isotope effect. These results therefore suggest that both vicinal chlorine substituents of TCE were reactive (intramolecular competition. This finding puts new constraints on mechanistic scenarios and favours either nucleophilic addition by Co(I or single electron transfer as reductive dehalogenation mechanisms.

  18. Insights into the reactivation of cobalamin-dependent methionine synthase

    Energy Technology Data Exchange (ETDEWEB)

    Koutmos, Markos; Datta, Supratim; Pattridge, Katherine A.; Smith, Janet L.; Matthews, Rowena G.; (Michigan)

    2009-12-10

    Cobalamin-dependent methionine synthase (MetH) is a modular protein that catalyzes the transfer of a methyl group from methyltetrahydrofolate to homocysteine to produce methionine and tetrahydrofolate. The cobalamin cofactor, which serves as both acceptor and donor of the methyl group, is oxidized once every {approx}2,000 catalytic cycles and must be reactivated by the uptake of an electron from reduced flavodoxin and a methyl group from S-adenosyl-L-methionine (AdoMet). Previous structures of a C-terminal fragment of MetH (MetH{sup CT}) revealed a reactivation conformation that juxtaposes the cobalamin- and AdoMet-binding domains. Here we describe 2 structures of a disulfide stabilized MetH{sup CT} ({sub s-s}MetH{sup CT}) that offer further insight into the reactivation of MetH. The structure of {sub s-s}MetH{sup CT} with cob(II)alamin and S-adenosyl-L-homocysteine represents the enzyme in the reactivation step preceding electron transfer from flavodoxin. The structure supports earlier suggestions that the enzyme acts to lower the reduction potential of the Co(II)/Co(I) couple by elongating the bond between the cobalt and its upper axial water ligand, effectively making the cobalt 4-coordinate, and illuminates the role of Tyr-1139 in the stabilization of this 4-coordinate state. The structure of {sub s-s}MetH{sub CT} with aquocobalamin may represent a transient state at the end of reactivation as the newly remethylated 5-coordinate methylcobalamin returns to the 6-coordinate state, triggering the rearrangement to a catalytic conformation.

  19. Durability of metals from archaeological objects, metal meteorites, and native metals

    International Nuclear Information System (INIS)

    Johnson, A.B. Jr.; Francis, B.

    1980-01-01

    Metal durability is an important consideration in the multi-barrier nuclear waste storage concept. This study summarizes the ancient metals, the environments, and factors which appear to have contributed to metal longevity. Archaeological and radiochemical dating suggest that human use of metals began in the period 6000 to 7000 BC. Gold is clearly the most durable, but many objects fashioned from silver, copper, bronze, iron, lead, and tin have survived for several thousand years. Dry environments, such as tombs, appear to be optimum for metal preservation, but some metals have survived in shipwrecks for over a thousand years. The metal meteorites are Fe-base alloys with 5 to 60 wt% Ni and minor amounts of Co, I, and S. Some meteoritic masses with ages estimated to be 5,000 to 20,000 years have weathered very little, while other masses from the same meteorites are in advanced stages of weathering. Native metals are natural metallic ores. Approximately five million tonnes were mined from native copper deposits in Michigan. Copper masses from the Michigan deposits were transported by the Pleistocene glaciers. Areas on the copper surfaces which appear to represent glacial abrasion show minimal corrosion. Dry cooling tower technology has demonstrated that in pollution-free moist environments, metals fare better at temperatures above than below the dewpoint. Thus, in moderate temperature regimes, elevated temperatures may be useful rather than detrimental for exposures of metal to air. In liquid environments, relatively complex radiolysis reactions can occur, particularly where multiple species are present. A dry environment largely obviates radiolysis effects

  20. Studies on radioecological concentration processes in the aquatic environments -Uptake and retention of Am-241 by fish-

    International Nuclear Information System (INIS)

    Nishiwaki, Y.; Kimura, Y.; Honda, Y.; Sakanoue, M.; Kobayashi, A.

    1977-01-01

    To elucidate radioecological concentration processes of Am by aquatic organisms, uptake and retention of Am-241 by fingerlings of rainbow trout were investigated under laboratory conditions using natural river water and with aeration. The results were compared with those of some other radionuclides such as Co-60, Ru-106, I-131, Cs-137 and Ce-144. The fractionation of the radionuclides in rearing waters using 0.45μm membrane filters showed that about 90% of Am as well as Ce were retained on the filters at apparent equilibrium states, while about 20% for RuNO-nitrato and less than 10% for nitro, oxygen-bridged binuclear Ru-complexes, Co, I and Cs, respectively. The pattern of whole-body uptake of Am was similar to that of Ce and the radioactivities in fish reached apparent equilibrium in about 10 days, whereas several days for the other radionuclides. The average concentration factor for Am was 1.8 and 6.5 for Co, 0.8 for Ru-chloro, 1.7 for Ru-nitro, 3.5 for Ru-nitrato, 0.9 for Ru-binuclear complexes, 1.9 for I, 1.3 for Cs, 1.8 for Ce, respectively. The tissue uptakes of Am as well as the other radionuclides except for I were the highest in visceral mass including digestive tracts and followed by gills. The alpha-track autoradiograms of frozen section of fish also demonstrated the occurrences of agglutinated Am in the digestive tracts. The initial whole-body retention of Am was about 85% in 10 days and thereafter gradually decreased. The elimination of Am from the tissues was the highest in gills and only about 9% of whole-body retention was observed in 20 days, whereas about 63% in visceral mass including digestive tracts

  1. A community-based oral health promotion model for HIV patients in Nairobi, East District in Kenya: a study protocol

    Directory of Open Access Journals (Sweden)

    Lucina N. Koyio

    2013-06-01

    Full Text Available Background: General HIV-related orofacial lesions, most commonly oropharyngeal candidiasis, have a typical clinical appearance and can be recognised by members of the community. Although affected patients often experience pain leading to compromised eating and swallowing, barriers such as social stigma and lack of knowledge regarding available services may prevent them from seeking early care. Educating the community about these lesions through community health workers (CHWs who are democratically elected community members may encourage individuals affected to seek early oral health-care in the health facilities. A health facility (HF is a health centre mainly run by clinical officers (CO, i.e. personnel with a 3-year medical training, and nurses. This study aims to evaluate the effect of a CHW training programme on: i their knowledge and recognition of HIV-related oral-facial lesions at a community level; and ii referral of affected patients from the community to the HFs. Design and Methods: All 800 CHWs in 2 administrative divisions of Nairobi East District (test group n=400; control group n=400 will be selected. The test group will receive training. CHWs in both groups will be assessed at 4 time points: −3, 0, +3 and +6 months with reference to the training on: i their knowledge of HIV-related orofacial lesions (using a written questionnaire; and ii their performance in referring affected patients to the HFs (using clinical data. Expected Impact: Early recognition of HIV-related orofacial lesions at a community level will prompt community members to seek early oral care, leading to early HIV testing and counselling regarding failure of antiretroviral therapy, while treatment outcomes are still favourable.

  2. Ion-exchange voltammetry of tris(2,2'-bipyridine) nickel(II), cobalt(II), and Co(salen) at polyestersulfonated ionomer coated electrodes in acetonitrile: Reactivity of the electrogenerated low-valent complexes

    International Nuclear Information System (INIS)

    Buriez, Olivier; Moretto, Ligia M.; Ugo, Paolo

    2006-01-01

    The electrochemical behaviour of [Ni(bpy) 3 (BF 4 ) 2 ], [Co(bpy) 3 (BF 4 ) 2 ], and Co(salen) (where bpy = 2,2'-bipyridine, and salen N,N'-bis(salicylidene)ethylenediamine) is studied at a glassy carbon electrode modified with the poly(estersulfonate) ionomer Eastman AQ 55 in acetonitrile (MeCN). It is shown that the nickel complex is strongly incorporated into the polymer. The reduction of the divalent nickel compound features a two-electron process leading to a nickel(0) species which is released from the coating because of the lack of electrostatic attraction with the ionomer. Yet, the neutral zerovalent nickel-bipyridine complex is reactive towards ethyl 4-iodobenzoate and di-bromocyclohexane despite the presence of the polymer. The activation of the aryl halide occurs through an oxidative addition, whereas, an electron transfer is involved in the presence of the alkyl halide making the catalyst regeneration much faster in the latter case. The electrochemical study of [Co(bpy) 3 (BF 4 ) 2 ] shows that incorporation of the cobalt complex into the polymer is efficient, provided excess bpy is used. This excess bpy does not interfere with the electrocatalytic activity of the cobalt complex incorporated in the AQ coating and efficient electrocatalysis is observed towards di-bromocyclohexane and benzyl-bromide as substrates. Finally, replacement of the bpy ligand with the macrocycle N,N'-bis(salicylidene)ethylenediamine, salen, leads to the incorporation of the non-charged Co II (salen) complex into the AQ 55 polymer showing the relevancy of hydrophobic interactions. The reaction between the electrogenerated [Co I (salen)] - with 1,2-dibromocyclohexane exhibits a fast inner sphere electron transfer

  3. The First Atmospheric Characterization of a Habitable-Zone Exoplanet

    Science.gov (United States)

    Stevenson, Kevin; Bean, Jacob; Charbonneau, David; Desert, Jean-Michel; Fortney, Jonathan; Irwin, Jonathan; Kreidberg, Laura; Line, Michael; Montet, Ben; Morley, Caroline

    2015-10-01

    Exoplanet surveys have recently revealed nearby planets orbiting within stellar habitable zones. This highly-anticipated breakthrough brings us one step closer in our quest to identify cosmic biosignatures, the indicators of extrasolar life. To achieve our goal, we must first study the atmospheres of these temperate worlds to measure their compositions and determine the prevalence of obscuring clouds. Using observations from the K2 mission, Co-I Montet recently announced the discovery of a 2.2 Earth-radii planet within the habitable zone of its relatively bright, nearby M dwarf parent star, K2-18. This temperate world is currently the best habitable-zone target for atmospheric characterization. Congruent with currently planned HST observations, we propose a Spitzer program to measure the transmission spectrum of the first habitable-zone exoplanet. Both telescopes are essential to revealing K2-18b's chemical composition. In a cloud-free, hydrogen-dominated atmosphere, the precision achieved by these measurements will be sufficient to detect methane, ammonia, and water vapor, which are the dominant C, N, and O bearing species at these temperatures. In turn, elemental abundance constraints from a primordial atmosphere can tell us about the composition of a protoplanetary disk in which Earth-like planets could have formed. Conversely, if the atmosphere contains thick clouds then the multi-wavelength observations from K2, HST, and Spitzer will constrain the clouds' properties. Because temperature plays a key role in the formation of clouds, their detection within the atmosphere of this habitable-zone exoplanet would be an important signpost that serves as a guide to future investigations of smaller, rocky exoplanets. As K2 continues discovering more habitable-zone planets, it is imperative that we perform spectral reconnaissance with Spitzer to determine their physical characteristics and begin understanding the prevalence of potentially-obscuring clouds prior to the

  4. The evolutionary host switches of Polychromophilus: a multi-gene phylogeny of the bat malaria genus suggests a second invasion of mammals by a haemosporidian parasite

    Directory of Open Access Journals (Sweden)

    Witsenburg Fardo

    2012-02-01

    Full Text Available Abstract Background The majority of Haemosporida species infect birds or reptiles, but many important genera, including Plasmodium, infect mammals. Dipteran vectors shared by avian, reptilian and mammalian Haemosporida, suggest multiple invasions of Mammalia during haemosporidian evolution; yet, phylogenetic analyses have detected only a single invasion event. Until now, several important mammal-infecting genera have been absent in these analyses. This study focuses on the evolutionary origin of Polychromophilus, a unique malaria genus that only infects bats (Microchiroptera and is transmitted by bat flies (Nycteribiidae. Methods Two species of Polychromophilus were obtained from wild bats caught in Switzerland. These were molecularly characterized using four genes (asl, clpc, coI, cytb from the three different genomes (nucleus, apicoplast, mitochondrion. These data were then combined with data of 60 taxa of Haemosporida available in GenBank. Bayesian inference, maximum likelihood and a range of rooting methods were used to test specific hypotheses concerning the phylogenetic relationships between Polychromophilus and the other haemosporidian genera. Results The Polychromophilus melanipherus and Polychromophilus murinus samples show genetically distinct patterns and group according to species. The Bayesian tree topology suggests that the monophyletic clade of Polychromophilus falls within the avian/saurian clade of Plasmodium and directed hypothesis testing confirms the Plasmodium origin. Conclusion Polychromophilus' ancestor was most likely a bird- or reptile-infecting Plasmodium before it switched to bats. The invasion of mammals as hosts has, therefore, not been a unique event in the evolutionary history of Haemosporida, despite the suspected costs of adapting to a new host. This was, moreover, accompanied by a switch in dipteran host.

  5. Genetic and morphological variation of bee-parasitic Tropilaelaps mites (Acari: Laelapidae): new and re-defined species.

    Science.gov (United States)

    Anderson, Denis L; Morgan, Mathew J

    2007-01-01

    Mites in the genus Tropilaelaps are parasites of social honeybees. Two species, Tropilaelaps clareae and T. koenigerum, have been recorded and their primary hosts are presumed to be the giant honeybees of Asia, Apis dorsata and A. laboriosa. The most common species, T. clareae, is also an economically important pest of the introduced Western honeybee (A. mellifera) throughout Asia and is considered an emerging threat to world apiculture. In the studies reported here, genetic (mtDNA CO-I and nuclear ITS1-5.8S-ITS2 gene sequence) and morphological variation and host associations were examined among Tropilaelaps isolates collected from A. dorsata, A. laboriosa and A. mellifera throughout Asia and neighbouring regions. The results clearly indicate that the genus contains at least four species. Tropilaelaps clareae, previously assumed to be ubiquitous in Asia, was found to be two species, and it is here redefined as encompassing haplotypes (mites with distinct mtDNA gene sequences) that parasitise native A. dorsata breviligula and introduced A. mellifera in the Philippines and also native A. d. binghami on Sulawesi Island in Indonesia. Tropilaelaps mercedesae n. sp., which until now has been mistaken for T. clareae, encompasses haplotypes that, together with haplotypes of T. koenigerum, parasitise native A. d. dorsata in mainland Asia and Indonesia (except Sulawesi Island). It also parasitises introduced A. mellifera in these and surrounding regions and, with another new species, T. thaii n. sp., also parasitises A. laboriosa in mountainous Himalayan regions. Methods are described for identifying each species. These studies help to clarify the emerging threat of Tropilaelaps to world apiculture and will necessitate a revision of quarantine protocols for countries that import and export honeybees.

  6. A Quantitative Analysis of Undisclosed Conflicts of Interest in Pharmacology Textbooks.

    Science.gov (United States)

    Piper, Brian J; Telku, Hassenet M; Lambert, Drew A

    2015-01-01

    Disclosure of potential conflicts of interest (CoI) is a standard practice for many biomedical journals but not for educational materials. The goal of this investigation was to determine whether the authors of pharmacology textbooks have undisclosed financial CoIs and to identify author characteristics associated with CoIs. The presence of potential CoIs was evaluated by submitting author names (N = 403; 36.3% female) to a patent database (Google Scholar) as well as a database that reports on the compensation ($USD) received from 15 pharmaceutical companies (ProPublica's Dollars for Docs). All publications (N = 410) of the ten highest compensated authors from 2009 to 2013 and indexed in Pubmed were also examined for disclosure of additional companies that the authors received research support, consulted, or served on speaker's bureaus. A total of 134 patents had been awarded (Maximum = 18/author) to textbook authors. Relative to DiPiro's Pharmacotherapy: A Pathophysiologic Approach, contributors to Goodman and Gilman's Pharmacological Basis of Therapeutics and Katzung's Basic and Clinical Pharmacology were more frequently patent holders (OR = 6.45, P 1 patent (OR = 0.15, P < .0005). A total of $2,411,080 USD (28.3% for speaking, 27.0% for consulting, and 23.9% for research), was received by 53 authors (Range = $299 to $310,000/author). Highly compensated authors were from multiple fields including oncology, psychiatry, neurology, and urology. The maximum number of additional companies, not currently indexed in the Dollars for Docs database, for which an author had potential CoIs was 73. Financial CoIs are common among the authors of pharmacology and pharmacotherapy textbooks. Full transparency of potential CoIs, particularly patents, should become standard procedure for future editions of educational materials in pharmacology.

  7. Validation of the model for ELM suppression with 3D magnetic fields using low torque ITER baseline scenario discharges in DIII-D

    Science.gov (United States)

    Moyer, R. A.; Paz-Soldan, C.; Nazikian, R.; Orlov, D. M.; Ferraro, N. M.; Grierson, B. A.; Knölker, M.; Lyons, B. C.; McKee, G. R.; Osborne, T. H.; Rhodes, T. L.; Meneghini, O.; Smith, S.; Evans, T. E.; Fenstermacher, M. E.; Groebner, R. J.; Hanson, J. M.; La Haye, R. J.; Luce, T. C.; Mordijck, S.; Solomon, W. M.; Turco, F.; Yan, Z.; Zeng, L.; DIII-D Team

    2017-10-01

    Experiments have been executed in the DIII-D tokamak to extend suppression of Edge Localized Modes (ELMs) with Resonant Magnetic Perturbations (RMPs) to ITER-relevant levels of beam torque. The results support the hypothesis for RMP ELM suppression based on transition from an ideal screened response to a tearing response at a resonant surface that prevents expansion of the pedestal to an unstable width [Snyder et al., Nucl. Fusion 51, 103016 (2011) and Wade et al., Nucl. Fusion 55, 023002 (2015)]. In ITER baseline plasmas with I/aB = 1.4 and pedestal ν * ˜ 0.15, ELMs are readily suppressed with co- I p neutral beam injection. However, reducing the beam torque from 5 Nm to ≤ 3.5 Nm results in loss of ELM suppression and a shift in the zero-crossing of the electron perpendicular rotation ω ⊥ e ˜ 0 deeper into the plasma. The change in radius of ω ⊥ e ˜ 0 is due primarily to changes to the electron diamagnetic rotation frequency ωe * . Linear plasma response modeling with the resistive MHD code m3d-c1 indicates that the tearing response location tracks the inward shift in ω ⊥ e ˜ 0. At pedestal ν * ˜ 1, ELM suppression is also lost when the beam torque is reduced, but the ω ⊥ e change is dominated by collapse of the toroidal rotation v T . The hypothesis predicts that it should be possible to obtain ELM suppression at reduced beam torque by also reducing the height and width of the ωe * profile. This prediction has been confirmed experimentally with RMP ELM suppression at 0 Nm of beam torque and plasma normalized pressure β N ˜ 0.7. This opens the possibility of accessing ELM suppression in low torque ITER baseline plasmas by establishing suppression at low beta and then increasing beta while relying on the strong RMP-island coupling to maintain suppression.

  8. New constraints on terrestrial and oceanic sources of atmospheric methanol

    Directory of Open Access Journals (Sweden)

    D. B. Millet

    2008-12-01

    Full Text Available We use a global 3-D chemical transport model (GEOS-Chem to interpret new aircraft, surface, and oceanic observations of methanol in terms of the constraints that they place on the atmospheric methanol budget. Recent measurements of methanol concentrations in the ocean mixed layer (OML imply that in situ biological production must be the main methanol source in the OML, dominating over uptake from the atmosphere. It follows that oceanic emission and uptake must be viewed as independent terms in the atmospheric methanol budget. We deduce that the marine biosphere is a large primary source (85 Tg a−1 of methanol to the atmosphere and is also a large sink (101 Tg a−1, comparable in magnitude to atmospheric oxidation by OH (88 Tg a−1. The resulting atmospheric lifetime of methanol in the model is 4.7 days. Aircraft measurements in the North American boundary layer imply that terrestrial plants are a much weaker source than presently thought, likely reflecting an overestimate of broadleaf tree emissions, and this is also generally consistent with surface measurements. We deduce a terrestrial plant source of 80 Tg a−1, comparable in magnitude to the ocean source. The aircraft measurements show a strong correlation with CO (<i>R2=0.51−0.61 over North America during summer. We reproduce this correlation and slope in the model with the reduced plant source, which also confirms that the anthropogenic source of methanol must be small. Our reduced plant source also provides a better simulation of methanol observations over tropical South America.

  9. Polyphyly and gene flow between non-sibling Heliconius species

    Directory of Open Access Journals (Sweden)

    Jiggins Chris D

    2006-04-01

    Full Text Available Abstract Background The view that gene flow between related animal species is rare and evolutionarily unimportant largely antedates sensitive molecular techniques. Here we use DNA sequencing to investigate a pair of morphologically and ecologically divergent, non-sibling butterfly species, Heliconius cydno and H. melpomene (Lepidoptera: Nymphalidae, whose distributions overlap in Central and Northwestern South America. Results In these taxa, we sequenced 30–45 haplotypes per locus of a mitochondrial region containing the genes for cytochrome oxidase subunits I and II (CoI/CoII, and intron-spanning fragments of three unlinked nuclear loci: triose-phosphate isomerase (Tpi, mannose-6-phosphate isomerase (Mpi and cubitus interruptus (Ci genes. A fifth gene, dopa decarboxylase (Ddc produced sequence data likely to be from different duplicate loci in some of the taxa, and so was excluded. Mitochondrial and Tpi genealogies are consistent with reciprocal monophyly, whereas sympatric populations of the species in Panama share identical or similar Mpi and Ci haplotypes, giving rise to genealogical polyphyly at the species level despite evidence for rapid sequence divergence at these genes between geographic races of H. melpomene. Conclusion Recent transfer of Mpi haplotypes between species is strongly supported, but there is no evidence for introgression at the other three loci. Our results demonstrate that the boundaries between animal species can remain selectively porous to gene flow long after speciation, and that introgression, even between non-sibling species, can be an important factor in animal evolution. Interspecific gene flow is demonstrated here for the first time in Heliconius and may provide a route for the transfer of switch-gene adaptations for Müllerian mimicry. The results also forcefully demonstrate how reliance on a single locus may give an erroneous picture of the overall genealogical history of speciation and gene flow.

  10. Development of radiation shielding materials and NBC pads for infantry combat vehicle and tank

    International Nuclear Information System (INIS)

    Pal, R.S.; Gautam, O.P.; Katiyar, Mohit; Tripathi, D.N.; Singh, R.K.

    2008-01-01

    Tanks have special lining materials inside, providing a certain degree of radiation protection for operation in nuclear scenario's. At present these special lining materials in the form of sheets are imported and are fitted into armoured vehicles. Three types of polymer compositions; PE(M)SE, PEC-ISE and PEC-IISE were formulated based on polymer matrix, specific fillers and anti-ageing additives. Prototype NBC pads based on polymer composition PEC-ISE was finalized for moulding of NBC pads for use in ICVs and composition PE(M)SE was finalized for T-90 tanks. The physico-mechanical properties for NBC pads have been evaluated. Radiography of test samples was conducted to ensure homogeneity of specific fillers in the polymer matrix. Radiation shielding factors against nuclear radiation sources ( 60 Co, I37 Cs and 252 Cf) were evaluated at DL Jodhpur and found to be better than imported Russian Pads designed for ICVs and T-90 Tanks. Drawings for twelve types of NBC pads for ICVs and one hundred eighteen types of pads for T-90 tank were generated with the help of design tool, Auto Desk Inventor-II and metallic moulds for moulding of NBC pads were fabricated. Prototype NBC pads were moulded through compression moulding process. Radiation protection factors of prototype NBC pads, after fitment in ICVs, were also evaluated against neutron and gamma (primary and secondary) radiation sources. Prototype NBC pads for ICVs have shown 20% improvement in overall protection level and NBC pads for T-90 tanks have been developed as per design requirements. Manufacturing facility for NBC shielding pads have been established in association with industries. (author)

  11. Durability of metals from archaeological objects, metal meteorites, and native metals

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, A.B. Jr.; Francis, B.

    1980-01-01

    Metal durability is an important consideration in the multi-barrier nuclear waste storage concept. This study summarizes the ancient metals, the environments, and factors which appear to have contributed to metal longevity. Archaeological and radiochemical dating suggest that human use of metals began in the period 6000 to 7000 BC. Gold is clearly the most durable, but many objects fashioned from silver, copper, bronze, iron, lead, and tin have survived for several thousand years. Dry environments, such as tombs, appear to be optimum for metal preservation, but some metals have survived in shipwrecks for over a thousand years. The metal meteorites are Fe-base alloys with 5 to 60 wt% Ni and minor amounts of Co, I, and S. Some meteoritic masses with ages estimated to be 5,000 to 20,000 years have weathered very little, while other masses from the same meteorites are in advanced stages of weathering. Native metals are natural metallic ores. Approximately five million tonnes were mined from native copper deposits in Michigan. Copper masses from the Michigan deposits were transported by the Pleistocene glaciers. Areas on the copper surfaces which appear to represent glacial abrasion show minimal corrosion. Dry cooling tower technology has demonstrated that in pollution-free moist environments, metals fare better at temperatures above than below the dewpoint. Thus, in moderate temperature regimes, elevated temperatures may be useful rather than detrimental for exposures of metal to air. In liquid environments, relatively complex radiolysis reactions can occur, particularly where multiple species are present. A dry environment largely obviates radiolysis effects.

  12. MO-DE-202-03: Image-Guided Surgery and Interventions in the Advanced Multimodality Image-Guided Operating (AMIGO) Suite

    International Nuclear Information System (INIS)

    Kapur, T.

    2016-01-01

    Disclosure and CoI: IGI Technologies, small-business partner on the grants

  13. MO-DE-202-02: Advances in Image Registration and Reconstruction for Image-Guided Neurosurgery

    International Nuclear Information System (INIS)

    Siewerdsen, J.

    2016-01-01

    Disclosure and CoI: IGI Technologies, small-business partner on the grants

  14. MO-DE-202-01: Image-Guided Focused Ultrasound Surgery and Therapy

    International Nuclear Information System (INIS)

    Farahani, K.

    2016-01-01

    Disclosure and CoI: IGI Technologies, small-business partner on the grants

  15. MO-DE-202-04: Multimodality Image-Guided Surgery and Intervention: For the Rest of Us

    International Nuclear Information System (INIS)

    Shekhar, R.

    2016-01-01

    Disclosure and CoI: IGI Technologies, small-business partner on the grants

  16. Indicadores para estimativa da digestibilidade parcial em bovinos Markers for measurements of partial digestion in cattle

    Directory of Open Access Journals (Sweden)

    Marcia Dias

    2007-06-01

    period (daytime vs. diurnal on nutrient digestion. Four crossbred Holstein x Zebu heifers fitted with ruminal and ileal cannulas were used in this trial. Animals were housed in individual pens and fed ad libitum bermudagrass hay plus 1 kg of concentrate (27% CP. The experiment lasted 60 days with seven days for diet adaptation and four days interval between each of the three 15-days experimental periods. Total fecal collection was done on day 1, 7, and 13, omasal sampling from day 2 to 4, and ileal digesta collection from day 8 to 10 of each period. Single [indigestible neutral detergent fiber (iNDF, indigestible acid detergent fiber (iADF, and chromium oxide (Cr2O3] and double system markers [Co-EDTA plus iNDF (Co-iNDF and Co-EDTA plus iADF (Co-iADF were used to measure flow of omasal digesta. Only single markers were used to determine ileal digesta flow. No significant difference was observed on partial nutrient digestibility comparing samples collected during the daytime with those collected during a 24-h period (diurnal suggesting that samples may be collect only during the daytime. Although iNDF, iADF and Co-iADF can all be used to estimate partial digestion of nutrients flowing past the omasum, it is recommended the use of internal markers (iNDF or iADF because of low costs and simple determination.

  17. Development of Small-Pixel CZT Detectors for Future High-Resolution Hard X-ray Missions

    Science.gov (United States)

    Beilicke, Matthias

    Owing to recent breakthroughs in grazing incidence mirror technology, next-generation hard X-ray telescopes will achieve angular resolutions of between 5 and 10 arc seconds - about an order of magnitude better than that of the NuSTAR hard X-ray telescope. As a consequence, the next generation of hard X-ray telescopes will require pixelated hard X- ray detectors with pixels on a grid with a lattice constant of between 120 and 240 um. Additional detector requirements include a low energy threshold of less than 5 keV and an energy resolution of less than 1 keV. The science drivers for a high angular-resolution hard X-ray mission include studies and measurements of black hole spins, the cosmic evolution of super-massive black holes, AGN feedback, and the behavior of matter at very high densities. We propose a R&D research program to develop, optimize and study the performance of 100-200 um pixel pitch CdTe and Cadmium Zinc Telluride (CZT) detectors of 1-2 mm thickness. Our program aims at a comparison of the performance achieved with CdTe and CZT detectors, and the optimization of the pixel, steering grid, and guard ring anode patterns. Although these studies will use existing ASICs (Application Specific Integrated Circuits), our program also includes modest funds for the development of an ultra-low noise ASIC with a 2-D grid of readout pads that can be directly bonded to the 100-200 um pixel pitch CdTe and CZT detectors. The team includes the Washington University group (Prof. M. Beilicke and Co-I Prof. H.S.W. Krawczynski et al.), and co-investigator G. De Geronimo at Brookhaven National Laboratory (BNL). The Washington University group has a 10 year track record of innovative CZT detector R&D sponsored by the NASA Astronomy and Physics Research and Analysis (APRA) program. The accomplishments to date include the development of CZT detectors with pixel pitches between 350 um and 2.5 mm for the ProtoExist, EXIST, and X-Calibur hard X-ray missions with some of the best

  18. A Climatology of Tropospheric CO over the Central and Southeastern United States and the Southwestern Pacific Ocean Derived from Space, Air, and Ground-based Infrared Interferometer Spectra

    Science.gov (United States)

    McMillian, W. Wallace; Strow, L. Larrabee; Revercomb, H.; Knuteson, R.; Thompson, A.

    2003-01-01

    This final report summarizes all research activities and publications undertaken as part of NASA Atmospheric Chemistry and Modeling Analysis Program (ACMAP) Grant NAG-1-2022, 'A Climatology of Tropospheric CO over the Central and Southeastern United States and the Southwestern Pacific Ocean Derived from Space, Air, and Ground-based Infrared Interferometer Spectra'. Major project accomplishments include: (1) analysis of more than 300,000 AERI spectra from the ARM SGP site yielding a 5-year (1998-2002) timeseries of CO retrievals from the Lamont, OK AERI; (2) development of a prototype CO profile retrieval algorithm for AERI spectra; (3) validation and publication of the first CO retrievals from the Scanning High-resolution Interferometer Sounder (SHIS); and (4) development of a prototype AERI tropospheric O3 retrieval algorithm. Compilation and publication of the 5-year Lamont, OK timeseries is underway including a new collaboration with scientists at the Lawrence Berkeley National Laboratory. Public access to this data will be provided upon article submission. A comprehensive CO analysis of the archive of HIS spectra of remains as the only originally proposed activity with little progress. The greatest challenge faced in this project was motivating the University of Wisconsin Co-Investigators to deliver their archived HIS and AERIOO data along with the requisite temperature and water vapor profiles in a timely manner. Part of the supplied HIS dataset from ASHOE may be analyzed as part of a Master s Thesis under a separate project. Our success with the SAFARI 2000 SHIS CO analysis demonstrates the utility of such aircraft remote sensing data given the proper support from the instrument investigators. In addition to the PI and Co-I s, personnel involved in this CO climatology project include one Post Doctoral Fellow, one Research Scientist, two graduate students, and two undergraduate students. A total of fifteen presentations regarding research related to this

  19. The influence of carbon monoxide bolus on the measurement of total haemoglobin mass using the optimized CO-rebreathing method

    International Nuclear Information System (INIS)

    Turner, G; Richardson, A J; Maxwell, N S; Pringle, J S M; Ingham, S A; Fudge, B W

    2014-01-01

    The optimized carbon monoxide (CO) rebreathing method (oCOR-method) is routinely used to measure total haemoglobin mass (tHbmass). The tHbmass measure is subject to a test-retest typical error of ∼2%, mostly from the precision of carboxyhaemoglobin (HbCO) measurement. We hypothesized that tHbmass would be robust to differences in the bolus of CO administered during the oCOR-method. Twelve participants (ten males and two females; age 27 ± 6 yr, height 177 ± 11 cm and mass 73.9 ± 12.1 kg) completed the oCOR-method on four occasions. Different bolus of CO were administered (LOW: 0.6 ml kg −1 ; MED 1 : 1.0 ml kg −1  and HIGH: 1.4 ml kg −1 ); to determine the reliability of MED 1 , a second trial was conducted (MED 2 ). tHbmass was found to be significantly less from the HIGH CO bolus (776 ± 148 g) when compared to the LOW CO (791 ± 149 g) or MED 1  CO (788 ± 149 g) trials. MED 2  CO was 785 ± 150 g. The measurement of tHbmass is repeatable to within 0.8%, but a small and notable difference was seen when using a HIGH CO bolus (1.4 to 1.9% less), potentially due to differences in CO uptake kinetics. Previously, an improved precision of the oCOR-method was thought to require a higher bolus of CO (i.e. larger ▵%HbCO), as commercial hemoximeters only estimate %HbCO levels to a single decimal place (usually ± 0.1%). With the new hemoximeter used in this study, a bolus of 1.0 ml kg −1  allows adequate precision with acceptable safety. (note)

  20. Non-financial conflicts of interest in academic grant evaluation: a qualitative study of multiple stakeholders in France.

    Science.gov (United States)

    Abdoul, Hendy; Perrey, Christophe; Tubach, Florence; Amiel, Philippe; Durand-Zaleski, Isabelle; Alberti, Corinne

    2012-01-01

    Peer review is the most widely used method for evaluating grant applications in clinical research. Criticisms of peer review include lack of equity, suspicion of biases, and conflicts of interest (CoI). CoIs raise questions of fairness, transparency, and trust in grant allocation. Few observational studies have assessed these issues. We report the results of a qualitative study on reviewers' and applicants' perceptions and experiences of CoIs in reviews of French academic grant applications. We designed a qualitative study using semi-structured interviews and direct observation. We asked members of assessment panels, external reviewers, and applicants to participate in semi-structured interviews. Two independent researchers conducted in-depth reviews and line-by-line coding of all transcribed interviews, which were also subjected to Tropes® software text analysis, to detect and qualify themes associated with CoIs. Most participants (73/98) spontaneously reported that non-financial CoIs predominated over financial CoIs. Non-financial CoIs mainly involved rivalry among disciplines, cronyism, and geographic and academic biases. However, none of the participants challenged the validity of peer review. Reviewers who felt they might be affected by CoIs said they reacted in a variety of ways: routine refusal to review, routine attempt to conduct an impartial review, or decision on a case-by-case basis. Multiple means of managing non-financial CoIs were suggested, including increased transparency throughout the review process, with public disclosure of non-financial CoIs, and careful selection of independent reviewers, including foreign experts and methodologists. Our study underscores the importance of considering non-financial CoIs when reviewing research grant applications, in addition to financial CoIs. Specific measures are needed to prevent a negative impact of non-financial CoIs on the fairness of resource allocation. Whether and how public disclosure of non

  1. Lack of population genetic structure and host specificity in the bat fly, Cyclopodia horsfieldi, across species of Pteropus bats in Southeast Asia.

    Science.gov (United States)

    Olival, Kevin J; Dick, Carl W; Simmons, Nancy B; Morales, Juan Carlos; Melnick, Don J; Dittmar, Katharina; Perkins, Susan L; Daszak, Peter; Desalle, Rob

    2013-08-08

    Population-level studies of parasites have the potential to elucidate patterns of host movement and cross-species interactions that are not evident from host genealogy alone. Bat flies are obligate and generally host-specific blood-feeding parasites of bats. Old-World flies in the family Nycteribiidae are entirely wingless and depend on their hosts for long-distance dispersal; their population genetics has been unstudied to date. We collected a total of 125 bat flies from three Pteropus species (Pteropus vampyrus, P. hypomelanus, and P. lylei) from eight localities in Malaysia, Cambodia, and Vietnam. We identified specimens morphologically and then sequenced three mitochondrial DNA gene fragments (CoI, CoII, cytB; 1744 basepairs total) from a subset of 45 bat flies. We measured genetic diversity, molecular variance, and population genetic subdivision (FST), and used phylogenetic and haplotype network analyses to quantify parasite genetic structure across host species and localities. All flies were identified as Cyclopodia horsfieldi with the exception of two individuals of Eucampsipoda sundaica. Low levels of population genetic structure were detected between populations of Cyclopodia horsfieldi from across a wide geographic range (~1000 km), and tests for isolation by distance were rejected. AMOVA results support a lack of geographic and host-specific population structure, with molecular variance primarily partitioned within populations. Pairwise FST values from flies collected from island populations of Pteropus hypomelanus in East and West Peninsular Malaysia supported predictions based on previous studies of host genetic structure. The lack of population genetic structure and morphological variation observed in Cyclopodia horsfieldi is most likely due to frequent contact between flying fox species and subsequent high levels of parasite gene flow. Specifically, we suggest that Pteropus vampyrus may facilitate movement of bat flies between the three Pteropus

  2. Influence of Reaction Medium on CO2 Photocatalytic Reduction Yields Over Zns-MMT / Vliv Reakčního Prostření Na Výtěžky Fotokatalytické Redukce CO2 V Přítomnosti Zns-MMT

    Directory of Open Access Journals (Sweden)

    Reli Martin

    2012-10-01

    Full Text Available Redukce CO2 pomocí fotokatalyzátorů je jedna z nejslibnějších metod, jelikož CO2 může být redukován na užitečné sloučeniny ozařováním UV zářením při pokojové teplotě a tlaku. Tato práce byla zaměřena na posouzení vlivu reakčních prostředí na výtěžky fotokatalytické redukce CO2 v přítomnosti nanočástic ZnS nanesených na montmorillonit (ZnS-MMT. Byla testována čtyři různá reakční prostředí, NaOH, NaOH+Na2SO3 (1:1, NH4OH, NH4OH+Na2SO3 (1:1. Výtěžky v obou fázích, plynné (CH4 a CO i kapalné (CH3OH, byly vyšší v čistém hydroxidu sodném než v hydroxidu amonném. Přídavek Na2SO3 zvýšil výtěžky methanolu a to díky zamezení oxidace vznikajícího methanolu zpět na oxid uhličitý. Výtěžky plynné fáze se však po přídavku Na2SO3 snížily. Nejlepším z testovaných reakčních prostředí pro fotokatalytickou redukci CO2 byl roztok hydroxidu sodného.

  3. Collaborative research: Dynamics of electrostatic solitary waves and their effects on current layers

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Li-Jen

    2014-04-18

    The project has accomplished the following achievements including the goals outlined in the original proposal. Generation and measurements of Debye-scale electron holes in laboratory: We have generated by beam injections electron solitary waves in the LAPD experiments. The measurements were made possible by the fabrication of the state-of-the-art microprobes at UCLA to measure Debye-scale electric fields [Chiang et al., 2011]. We obtained a result that challenged the state of knowledge about electron hole generation. We found that the electron holes were not due to two-stream instability, but generated by a current-driven instability that also generated whistler-mode waves [Lefebvre et al., 2011, 2010b]. Most of the grant supported a young research scientist Bertrand Lefebvre who led the dissemination of the laboratory experimental results. In addition to two publications, our work relevant to the laboratory experiments on electron holes has resulted in 7 invited talks [Chen, 2007, 2009; Pickett et al., 2009a; Lefebvre et al., 2010a; Pickett et al., 2010; Chen et al., 2011c, b] (including those given by the co-I Jolene Pickett) and 2 contributed talks [Lefebvre et al., 2009b, a]. Discovery of elecctron phase-space-hole structure in the reconnection electron layer: Our theoretical analyses and simulations under this project led to the discovery of an inversion electric field layer whose phase-space signature is an electron hole within the electron diffusion layer in 2D anti-parallel reconnection [Chen et al., 2011a]. We carried out particle tracing studies to understand the electron orbits that result in the phase-space hole structure. Most importantly, we showed that the current density in the electron layer is limited in collisionless reconnection with negligible guide field by the cyclotron turning of meandering electrons. Comparison of electrostatic solitary waves in current layers observed by Cluster and in LAPD: We compared the ESWs observed in a supersubstorm

  4. Non-financial conflicts of interest in academic grant evaluation: a qualitative study of multiple stakeholders in France.

    Directory of Open Access Journals (Sweden)

    Hendy Abdoul

    Full Text Available BACKGROUND: Peer review is the most widely used method for evaluating grant applications in clinical research. Criticisms of peer review include lack of equity, suspicion of biases, and conflicts of interest (CoI. CoIs raise questions of fairness, transparency, and trust in grant allocation. Few observational studies have assessed these issues. We report the results of a qualitative study on reviewers' and applicants' perceptions and experiences of CoIs in reviews of French academic grant applications. METHODOLOGY AND PRINCIPAL FINDINGS: We designed a qualitative study using semi-structured interviews and direct observation. We asked members of assessment panels, external reviewers, and applicants to participate in semi-structured interviews. Two independent researchers conducted in-depth reviews and line-by-line coding of all transcribed interviews, which were also subjected to Tropes® software text analysis, to detect and qualify themes associated with CoIs. Most participants (73/98 spontaneously reported that non-financial CoIs predominated over financial CoIs. Non-financial CoIs mainly involved rivalry among disciplines, cronyism, and geographic and academic biases. However, none of the participants challenged the validity of peer review. Reviewers who felt they might be affected by CoIs said they reacted in a variety of ways: routine refusal to review, routine attempt to conduct an impartial review, or decision on a case-by-case basis. Multiple means of managing non-financial CoIs were suggested, including increased transparency throughout the review process, with public disclosure of non-financial CoIs, and careful selection of independent reviewers, including foreign experts and methodologists. CONCLUSIONS: Our study underscores the importance of considering non-financial CoIs when reviewing research grant applications, in addition to financial CoIs. Specific measures are needed to prevent a negative impact of non-financial CoIs on the

  5. WE-AB-BRA-11: Improved Imaging of Permanent Prostate Brachytherapy Seed Implants by Combining an Endorectal X-Ray Sensor with a CT Scanner

    International Nuclear Information System (INIS)

    Steiner, J; Matthews, K; Jia, G

    2016-01-01

    . Disclosure: XDR Radiography has loaned our research group the digital x-ray detector used in this work. CoI: None.

  6. Interpretation of Aura satellite observations of CO and aerosol index related to the December 2006 Australia fires

    Science.gov (United States)

    Luo, M.; Boxe, C.; Jiang, J.; Nassar, R.; Livesey, N.

    2009-11-01

    Enhanced Carbon Monoxide (CO) in the upper troposphere (UT) is shown by collocated Tropospheric Emission Spectrometer (TES) and Microwave Limb Sounder (MLS) measurements near and down-wind from the known wildfire region of SE Australia from 12-19 December 2006. Enhanced UV aerosol index (AI) derived from Ozone Monitoring Instrument (OMI) measurements correlate with these high CO concentrations. HYSPLIT model back trajectories trace selected air parcels to the SE Australia fire region as their initial location, where TES observes enhanced CO in the upper and lower troposphere. Simultaneously, they show a lack of vertical advection along their tracks. TES retrieved CO vertical profiles in the higher and lower southern latitudes are examined together with the averaging kernels and show that TES CO retrievals are most sensitive at approximately 300-400 hPa. The enhanced CO observed by TES at the upper (215 hPa) and lower (681 hPa) troposphere are, therefore, influenced by mid-tropospheric CO. GEOS-Chem model simulations with an 8-day emission inventory, as the wildfire source over Australia, are sampled to the TES/MLS observation times and locations. These simulations only show CO enhancements in the lower troposphere near and down-wind from the wildfire region of SE Australia with drastic underestimates of UT CO. Although CloudSat along-track ice-water content curtains are examined to see whether possible vertical convection events can explain the high UT CO values, sparse observations of collocated Aura CO and CloudSat along-track ice-water content measurements for the single event precludes any conclusive correlation. Vertical convection that uplift fire-induced CO (i.e. most notably referred to as pyro-cumulonimbus, pyroCb) may provide an explanation for the incongruence between these simulations and the TES/MLS observations of enhanced CO in the UT. Future GEOS-Chem simulations are needed to validate this conjecture as the the PyroCb mechanism is currently not

  7. WE-AB-BRA-11: Improved Imaging of Permanent Prostate Brachytherapy Seed Implants by Combining an Endorectal X-Ray Sensor with a CT Scanner

    Energy Technology Data Exchange (ETDEWEB)

    Steiner, J; Matthews, K; Jia, G [Louisiana State University, Baton Rouge, LA (United States)

    2016-06-15

    . Disclosure: XDR Radiography has loaned our research group the digital x-ray detector used in this work. CoI: None.

  8. Using a Virtual Environment to Deliver Evidence-Based Interventions: The Facilitator's Experience

    Science.gov (United States)

    Villarruel, Antonia; Tschannen, Dana; Valladares, Angel; Yaksich, Joseph; Yeagley, Emily; Hawes, Armani

    2015-01-01

    Background Evidence-based interventions (EBIs) have the potential to maximize positive impact on communities. However, despite the quantity and quality of EBIs for prevention, the need for formalized training and associated training-related expenses, such as travel costs, program materials, and input of personnel hours, pose implementation challenges for many community-based organizations. In this study, the community of inquiry (CoI) framework was used to develop the virtual learning environment to support the adaptation of the ¡Cuídate! (Take Care of Yourself!) Training of Facilitators curriculum (an EBI) to train facilitators from community-based organizations. Objective The purpose of this study was to examine the feasibility of adapting a traditional face-to-face facilitator training program for ¡Cuídate!, a sexual risk reduction EBI for Latino youth, for use in a multi-user virtual environment (MUVE). Additionally, two aims of the study were explored: the acceptability of the facilitator training and the level of the facilitators’ knowledge and self-efficacy to implement the training. Methods A total of 35 facilitators were trained in the virtual environment. We evaluated the facilitators' experience in the virtual training environment and determined if the learning environment was acceptable and supported the acquisition of learning outcomes. To this end, the facilitators were surveyed using a modified community of inquiry survey, with questions specific to the Second Life environment and an open-ended questionnaire. In addition, a comparison to face-to-face training was conducted using survey methods. Results Results of the community of inquiry survey demonstrated a subscale mean of 23.11 (SD 4.12) out of a possible 30 on social presence, a subscale mean of 8.74 (SD 1.01) out of a possible 10 on teaching presence, and a subscale mean of 16.69 (SD 1.97) out of a possible 20 on cognitive presence. The comparison to face-to-face training showed no

  9. Skew scattering dominated anomalous Hall effect in Cox(MgO)100-x granular thin films

    KAUST Repository

    Zhang, Qiang

    2017-07-31

    We investigated the mechanism(s) of the anomalous Hall effect (AHE) in magnetic granular materials by fabricating 100-nm-thick thin films of Co>x(MgO)100-x with a Co volume fraction of 34≤x≤100 using co-sputtering at room temperature. We measured the temperature dependence of longitudinal resistivity (ρxx) and anomalous Hall resistivity (ρAHE) from 5 K to 300 K in all samples. We found that when x decreases from 100 to 34, the values of ρxx and ρAHE respectively increased by about four and three orders in magnitude. By linearly fitting the data, obtained at 5 K, of anomalous Hall coefficient (Rs) and of ρxx to log(Rs)~γlog(ρxx), we found that our results perfectly fell on a straight line with a slope of γ= 0.97±0.02. This fitting value of γ in Rsρxxγ clearly suggests that skew scattering dominated the AHE in this granular system. To explore the effect of the scattering on the AHE, we performed the same measurements on annealed samples. We found that although both ρxx and ρAHE significantly reduced after annealing, the correlation between them was almost the same, which was confirmed by the fitted value, γ=0.99±0.03. These data strongly suggest that the AHE originates from the skew scattering in Co-MgO granular thin films no matter how strong the scatterings of electrons by the interfaces and defects is. This observation may be of importance to the development of spintronic devices based on MgO.

  10. Structural and Kinetic Evidence for an Extended Hydrogen-Bonding Network in Catalysis of Methyl Group Transfer

    International Nuclear Information System (INIS)

    Doukov, T.; Hemmi, H.; Drennan, C.; Ragsdale, S.

    2007-01-01

    The methyltetrahydrofolate (CH 3 -H 4 folate) corrinoid-ironsulfur protein (CFeSP) methyltransferase (MeTr) catalyzes transfer of the methyl group of CH3-H4folate to cob(I)amide. This key step in anaerobic CO and CO 2 fixation is similar to the first half-reaction in the mechanisms of other cobalamin-dependent methyltransferases. Methyl transfer requires electrophilic activation of the methyl group of CH 3 -H 4 folate, which includes proton transfer to the N5 group of the pterin ring and poises the methyl group for reaction with the Co(I) nucleophile. The structure of the binary CH 3 -H 4 folate/MeTr complex (revealed here) lacks any obvious proton donor near the N5 group. Instead, an Asn residue and water molecules are found within H-bonding distance of N5. Structural and kinetic experiments described here are consistent with the involvement of an extended H-bonding network in proton transfer to N5 of the folate that includes an Asn (Asn-199 in MeTr), a conserved Asp (Asp-160), and a water molecule. This situation is reminiscent of purine nucleoside phosphorylase, which involves protonation of the purine N7 in the transition state and is accomplished by an extended H-bond network that includes water molecules, a Glu residue, and an Asn residue (Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Shi, W., Fedorov, A., Lewandowicz, A., Cahill, S. M., Almo, S. C., and Schramm, V. L. (2002) Biochemistry 41, 14489-14498). In MeTr, the Asn residue swings from a distant position to within H-bonding distance of the N5 atom upon CH 3 -H 4 folate binding. An N199A variant exhibits only ∼20-fold weakened affinity for CH 3 -H 4 folate but a much more marked 20,000-40,000-fold effect on catalysis, suggesting that Asn-199 plays an important role in stabilizing a transition state or high energy intermediate for methyl transfer

  11. The genera of Nematinae (Hymenoptera, Tenthredinidae

    Directory of Open Access Journals (Sweden)

    Marko Prous

    2014-10-01

    Full Text Available Recent phylogenetic studies on Nematinae based on DNA sequences have shown extensive incongruencies with current nomenclature of genus-group taxa. Here, we expand previous DNA sequence datasets based on three genes (CoI, Cytb, and EF-1α, to include a fourth (NaK and more genera. The analyses largely confirm the previous findings, particularly the existence of two well-supported large clades, Euura and Pristiphora, together comprising more than 75% of the species of Nematinae. Basal relationships within these two clades remain poorly resolved, mirroring the difficulties in delimiting genera based on morphology. In addition, a moderately supported small clade, Nematus, is found. The relationships between the Euura, Pristiphora, and Nematus clades are uncertain. Therefore, to stabilize the nomenclature we treat these clades as genera. This taxonomic treatment results in numerous new combinations of species names. The following synonymies are proposed for the available genus-group names. Synonyms of Euura Newman, 1837: Cryptocampus Hartig, 1837, Euura Agassiz, 1848, Pontania Costa, 1852, syn. n., Epitactus Förster, 1854, syn. n., Amauronematus Konow, 1890, syn. n., Holcocneme Konow, 1890, syn. n., Pachynematus Konow, 1890, syn. n., Holcocnema Schulz, 1906, syn. n., Holcocnemis Konow, 1907, syn. n., Pteronidea Rohwer, 1911, syn. n., Pontopristia Malaise, 1921, syn. n., Brachycoluma Strand, 1929, syn. n., Decanematus Malaise, 1931, syn. n., Pikonema Ross, 1937, syn. n., Phyllocolpa Benson, 1960, syn. n., Eitelius Kontuniemi, 1966, syn. n., Gemmura E.L. Smith, 1968, Eupontania Zinovjev, 1985, syn. n., Larinematus Zhelochovtsev, 1988, syn. n., Polynematus Zhelochovtsev, 1988, syn. n., Bacconematus Zhelochovtsev, 1988, syn. n., Alpinematus Lacourt, 1996, syn. n., Epicenematus Lacourt, 1998, syn. n., Kontuniemiana Lacourt, 1998, syn. n., Lindqvistia Lacourt, 1998, syn. n., Luea Wei and Nie, 1998, syn. n., and Tubpontania Vikberg, 2010, syn. n. Synonyms

  12. Synthesis, characterization, and photocatalytic activities of Cobalt(II)-Titanium dioxide nanorods, and electrophoretic deposition of Titanium dioxide nanoparticle/nanorod composite films for self-cleaning applications

    Science.gov (United States)

    Kang, Wonjun

    This dissertation consists of two projects. The first project is synthesis, characterization, and photocatalytic activities of Co(II)-TiO2 nanorods. We modified brookite TiO2 nanorods with cobalt(II) ions to design new photocatalysts with visible light absorption. X-ray absorption spectroscopy (XAS) and X-ray photoelectron spectroscopy (XPS) data indicated that the local structure of Co(II)-TiO2 nanorods was shown as tetrahedral and octahedral Co(II) sites at TiO2 nanorod surface. Dimethylglyoxime (DMG) has been used to remove surface Co(II) from Co(II)-TiO2 nanorods to determine single-site Co(II) ions selectively attached to the TiO 2 nanorod surface. We proposed a mechanism that the Co-Co bond of the precursor Co2(CO)8 undergoes heterolysis followed by disproportionation of Co(I) to produce Co(II) and Co(0) precipitate. Finally, the Co(II)-TiO2 nanorods showed greater activity than TiO 2 nanorods in the degradation of 5,8-dihydroxy-1,4-naphthoquinone (DHNQ) dye under visible light irradiation. The second project is electrophoretic deposition (EPD) of TiO2 nanoparticle/nanorod composite films for self-cleaning applications. We developed novel electrolyte system for EPD of TiO2 nanoparticle/nanorod composites for self-cleaning coatings. A mixture of TiO2 powder and TiO2 nanorods was used as EPD suspension in a mixture of THF and acetone. TiO2 nanoparticle/nanorod composite films were fabricated on aluminium substrates via the EPD method, and were characterized by scanning electron microscope (SEM). SEM images showed that TiO2 nanoparticle/nanorod composite films had a uniform pore structure. The hydrophobic properties of surfaces in TiO2 nanoparticle/nanorod composite films were evaluated by water contact angle measurements. It was found that the surfaces of TiO2 nanoparticle/nanorod composite films were hydrophobic with contact angle of 103°. These hydrophobic surfaces are expected to have potential applications for self-cleaning.

  13. Rocket Experiment Demonstration of a Soft X-ray Polarimeter

    Science.gov (United States)

    Marshall, Herman

    This proposal is the lead proposal. Boston University will submit, via NSPIRES, a Co-I proposal, per instructions for Suborbital proposals for multiple-award. Our scientific goal of the Rocket Experiment Demonstration of a Soft X-ray Polarimeter (REDSoX Polarimeter) is to make the first measurement of the linear X-ray polarization of an extragalactic source in the 0.2-0.8 keV band. The first flight of the REDSoX Polarimeter would target Mk 421, which is commonly modeled as a highly relativistic jet aimed nearly along the line of sight. Such sources are likely to be polarized at a level of 30-60%, so the goal is to obtain a significant detection even if it is as low as 10%. Significant revisions to the models of jets emanating from black holes at the cores of active galaxies would be required if the polarization fraction lower than 10%. We employ multilayer-coated mirrors as Bragg reflectors at the Brewster angle. By matching to the dispersion of a spectrometer, one may take advantage of high multilayer reflectivities and achieve polarization modulation factors over 90%. Using replicated foil mirrors from MSFC and gratings made at MIT, we construct a spectrometer that disperses to three laterally graded multilayer mirrors (LGMLs). The lateral grading changes the wavelength of the Bragg peak for 45 degree reflections linearly across the mirror, matching the dispersion of the spectrometer. By dividing the entrance aperture into six equal sectors, pairs of blazed gratings from opposite sectors are oriented to disperse to the same LGML. The position angles for the LGMLs are 120 degrees to each other. CCD detectors then measure the intensities of the dispersed spectra after reflection and polarizing by the LGMLs, giving the three Stokes parameters needed to determine the source polarization. We will rely on components whose performance has been verified in the laboratory or in space. The CCD detectors are based on Chandra and Suzaku heritage. The mirror fabrication team

  14. Understanding the residence of Co in ore minerals - towards the development of novel Co extraction strategies for laterite deposits

    Science.gov (United States)

    Dybowska, Agnieszka; Norman, Rachel; Schofield, Paul; Herrington, Richard

    2017-04-01

    XRD. These low abundance minerals, identified in the samples using Raman spectroscopy, µXRD and EPMA, proved however to be very important Co-hosting phases. Electron microscopy and µ-XRF mapping revealed a strong Mn and Co association in all samples but little correlation between Co and Fe. The important determinant of Co concentration is thus its association with Mn oxides, a variety of which have been found in the samples studied. For example, in Shevchenko laterite asbolane was identified with Co concentrations varying from 0.25 to 12.4 wt% (6.3 wt% on average). Goethite was found to carry only minor Co i.e. below 0.03 wt% or 0.1-0.2 wt%. In samples from the Nkamouna laterite Mn oxide minerals were found to contain Co ranging widely from below 1 wt% in tectomanganate phases such as hollandite and pyrolusite, 5.5% wt% in lithiophorite and up to 21 wt% in lithiophorite-asbolane intermediates. No Co or minor Co (<0.1 wt%) was detected in Fe oxides and oxy-hydroxides. XANES spectroscopy shows that Co is bound in a range of Mn oxide minerals as Co3+. The structural environment of Co in these minerals is very similar with Co in octahedral coordination. Analysis of the EXAFS data for asbolane shows an apparent high degree of structural order around Co which suggest that Co is present as clustered aggregates. Our results indicate that Co should be efficiently and selectively removed from the studied laterites by targeted solubilisation of Mn oxides, which can be achieved via, for example, microbially mediated reductive mineral dissolution.

  15. Bone-repair properties of biodegradable hydroxyapatite nano-rod superstructures

    Science.gov (United States)

    D'Elía, Noelia L.; Mathieu, Colleen; Hoemann, Caroline D.; Laiuppa, Juan A.; Santillán, Graciela E.; Messina, Paula V.

    2015-11-01

    for the in vitro conditions of bone-repair. Experiments are underway to investigate the effects of the material microstructure, surface roughness and hydrophilicity on their osseo-integration, osteo-conduction and osteo-induction abilities. Materials were tested in the presence of both, rat primary osteoblasts and rabbit mesenchymal stem cells. The following aspects are discussed: (i) cytotoxicity and material degradation; (ii) rat osteoblast spreading, proliferation and differentiation; and (iii) rabbit mesenchymal stem cell adhesion on nano-HAp and nano-HAp/collagen type I coatings. We effectively prepared a material based on biomimetic HAp nano-rods displaying the appropriate surface topography, hydrophilicity and degradation properties to induce the in vitro desired cellular responses for bone bonding and healing. Cells seeded on the selected material readily attached, proliferated and differentiated, as confirmed by cell viability, mitochondrial metabolic activity, alkaline phosphatase (ALP) activity and cytoskeletal integrity analysis by immunofluorescence localization of alpha-smooth muscle actin (α-SMA) protein. These results highlight the influence of material's surface characteristics to determine their tissue regeneration potential and their future use in engineering osteogenic scaffolds for orthopedic implants. Electronic supplementary information (ESI) available: Calculation of roughness parameters Rz, Rz,max, and Rz, prom. Nano-HAp powder degradation after immersion in phosphate buffer (pH = 7.4). Optical phase contrast microphotographs of MSC adhesion on nano-HAp and nano-HAp/Co I coatings at different concentrations. Laser scanning confocal microphotographs of MSCs' α-SMA expression spreading on large amounts of nano-HAp (MI) coatings. Immunofluorescence microphotograph analysis by image software. See DOI: 10.1039/c5nr04850h

  16. Instability, Turbulence, and Enhanced Transport in Collisionless Black-Hole Accretion Flows

    Science.gov (United States)

    Kunz, Matthew

    Many astrophysical plasmas are so hot and diffuse that the collisional mean free path is larger than the system size. Perhaps the best examples of such systems are lowluminosity accretion flows onto black holes such as Sgr A* at the center of our own Galaxy, or M87 in the Virgo cluster. To date, theoretical models of these accretion flows are based on magnetohydrodynamics (MHD), a collisional fluid theory, sometimes (but rarely) extended with non-MHD features such as anisotropic (i.e. magnetic-field-aligned) viscosity and thermal conduction. While these extensions have been recognized as crucial, they require ad hoc assumptions about the role of microscopic kinetic instabilities (namely, firehose and mirror) in regulating the transport properties. These assumptions strongly affect the outcome of the calculations, and yet they have never been tested using more fundamental (i.e. kinetic) models. This proposal outlines a comprehensive first-principles study of the plasma physics of collisionless accretion flows using both analytic and state-of-the-art numerical models. The latter will utilize a new hybrid-kinetic particle-in-cell code, Pegasus, developed by the PI and Co-I specifically to study this problem. A comprehensive kinetic study of the 3D saturation of the magnetorotational instability in a collisionless plasma will be performed, in order to understand the interplay between turbulence, transport, and Larmor-scale kinetic instabilities such as firehose and mirror. Whether such instabilities alter the macroscopic saturated state, for example by limiting the transport of angular momentum by anisotropic pressure, will be addressed. Using these results, an appropriate "fluid" closure will be developed that can capture the multi-scale effects of plasma kinetics on magnetorotational turbulence, for use by the astrophysics community in building evolutionary models of accretion disks. The PI has already successfully performed the first three-dimensional kinetic

  17. Deconstructing Constructivism: Modeling Causal Relationships Among Constructivist Learning Environment Factors and Student Outcomes in Introductory Chemistry

    Science.gov (United States)

    Komperda, Regis

    The purpose of this dissertation is to test a model of relationships among factors characterizing aspects of a student-centered constructivist learning environment and student outcomes of satisfaction and academic achievement in introductory undergraduate chemistry courses. Constructivism was chosen as the theoretical foundation for this research because of its widespread use in chemical education research and practice. In a constructivist learning environment the role of the teacher shifts from delivering content towards facilitating active student engagement in activities that encourage individual knowledge construction through discussion and application of content. Constructivist approaches to teaching introductory chemistry courses have been adopted by some instructors as a way to improve student outcomes, but little research has been done on the causal relationships among particular aspects of the learning environment and student outcomes. This makes it difficult for classroom teachers to know which aspects of a constructivist teaching approach are critical to adopt and which may be modified to better suit a particular learning environment while still improving student outcomes. To investigate a model of these relationships, a survey designed to measure student perceptions of three factors characterizing a constructivist learning environment in online courses was adapted for use in face-to-face chemistry courses. These three factors, teaching presence, social presence, and cognitive presence, were measured using a slightly modified version of the Community of Inquiry (CoI) instrument. The student outcomes investigated in this research were satisfaction and academic achievement, as measured by standardized American Chemical Society (ACS) exam scores and course grades. Structural equation modeling (SEM) was used to statistically model relationships among the three presence factors and student outcome variables for 391 students enrolled in six sections of a

  18. Ion Microprobe Measurements of Comet Dust and Implications for Models of Oxygen Isotope Heterogeneity in the Solar System

    Science.gov (United States)

    Snead, C. J.; McKeegan, K. D.; Keller, L. P.; Messenger, S.

    2017-01-01

    The oxygen isotopic compositions of anhydrous minerals in carbonaceous chondrites reflect mixing between a O-16-rich and O-17, O18-rich reservoir. The UV photodissociation of CO (i.e. selfshielding) has been proposed as a mass-independent mechanism for producing these isotopically distinct reservoirs. Self-shielding models predict the composition for the CO gas reservoir to be O-16-rich, and that the accreting primordial dust was in isotopic equilibrium with the gaseous reservoir [1, 2]. Self-shielding also predicts that cometary water, presumed to represent the O-17, O-18-rich reservoir, should be enriched in O-17 and O-18, with compositions of 200 -1000per mille, and that the interaction with this O-17, O-18-rich H2O reservoir altered the compositions of the primordial dust toward planetary values. The bulk composition of the solar nebula, which may be an approximation to the 16O-rich gaseous reservoir, has been constrained by the Genesis results [3]. However, material representing the O-17, O-18-rich end-member is rare [4], and dust representing the original accreting primordial dust has been challenging to conclusively identify in current collections. Anhydrous dust from comets, which accreted in the distal cold regions of the nebula at temperatures below approximately 30K, may provide the best opportunity to measure the oxygen isotope composition of primordial dust. Chondritic porous interplanetary dust particles (CP-IDPs) have been suggested as having cometary origins [5]; however, until direct comparisons with dust from a known comet parent body were made, link between CP-IDPs and comets remained circumstantial. Oxygen isotope analyses of particles from comet 81P/Wild 2 collected by NASA's Stardust mission have revealed surprising similarities to minerals in carbonaceous chondrites which have been interpreted as evidence for large scale radial migration of dust components from the inner solar nebula to the accretion regions of Jupiter- family comets [6

  19. Using phylogenetic and ionomic relationships to predict the uptake of radionuclides by any plant species

    Energy Technology Data Exchange (ETDEWEB)

    Willey, Neil J.; Siasou, Eleni [Centre for Research In Biosciences, University of the West of England, Coldharbour Lane, Frenchay, Bristol BS16 1QY (United Kingdom)

    2014-07-01

    It is not practical to empirically derive soil-to-plant TFs for all soil-plant combinations that are important in radiological assessments, so predictions for a range of species on different soils types are frequently impossible because TFs are unknown. This severely hampers predictions of both doses to biota and of the contamination of a variety of food chains with radioisotopes. Compilations of TFs in themselves provide no fundamental understanding of the plant factors that control the soil-to-plant transfer of radionuclides and thus no method of prediction. We have developed methods for the meta-analyses of radionuclide transfer data that can be used to make predictions of the transfer of radionuclides into any plants species for which TFs do not exist based on an understand of the plant factors that control radionuclide uptake. There is no reason a priori to think that variation in TF should be constrained by species. The species is, essentially, a reproductive unit and variation in many plant traits, some of which might control radionuclide uptake, occurs at taxonomic levels above the species. In the last 15 years genomic information has transformed the understanding of the evolutionary relationships of the living world so that new 'trees of life' (phylogenies) are now available. Using a Residual Maximum Likelihood modeling procedure to compile a significant proportion of all existing TF data onto a single scale, we here present a synthesis of the influence of phylogeny on variation in soil-to-plant TFs for radioisotopes of Cs, Sr, Co, I, Tc, and S. We show that a significant proportion of variation in TF is associated with major branches of the phylogeny of angiosperms (flowering plants) so that knowledge of a species' position on the phylogeny can be used to make predictions of transfer relative to other species. These phylogenetically-based predictions of relative transfer to any species can be used to make absolute predictions to any species

  20. A revision of the New Zealand weevil genus Irenimus Pascoe, 1876 (Coleoptera: Curculionidae: Entiminae).

    Science.gov (United States)

    Brown, Samuel D J

    2017-05-08

    The taxonomy of the New Zealand weevil genus Irenimus Pascoe, 1876 is revised, resulting in a narrower concept of the genus than has been considered in recent decades. In total, the genus now contains only seven species. In addition to the type species, I. parilis Pascoe, 1876, the genus contains I. duplex (Broun, 1904) and five newly described species: I. aniptus new species (type locality, Oamaru, DN), I. crinitus new species (type locality, Hakataramea Valley, SC), I. minimus new species (type locality, Alexandra, CO), I. stichus new species (type locality, Tekapo, MK) and I. thoracicus new species (type locality, Oamaru, DN). The genus Chalepistes new genus is established to contain the majority of species previously described in the genus Catoptes Schönherr, 1842, but also including species described in Brachyolus White, 1846; Irenimus Pascoe, 1876; Inophloeus Pascoe, 1875; and Nicaeana Pascoe, 1877. A total of 27 valid described species are new combinations with Chalepistes: C. aequalis (Broun, 1895) (from Irenimus), C. albosparsus (Broun, 1917) (from Irenimus), C. apicalis (Broun, 1923) (from Catoptes), C. asperatus (Broun, 1914) (from Brachyolus), C. compressus (Broun, 1880) (from Irenimus), C. costifer (Broun, 1886) (from Inophloeus), C. curvus (Barratt & Kuschel, 1996) (from Irenimus), C. dehiscens (Broun, 1917) (from Catoptes), C. dugdalei (Barratt & Kuschel, 1996) (from Irenimus), C. egens (Broun, 1904) (from Irenimus), C. inaequalis (Sharp, 1886) (from Brachyolus), C. instabilis (Marshall, 1931) (from Catoptes), C. latipennis (Broun, 1893) (from Catoptes), C. limbatus (Broun, 1909) (from Catoptes), C. lobatus (Broun, 1921) (from Catoptes), C. patricki (Barratt & Kuschel, 1996) (from Irenimus), C. pensus (Broun, 1914) (from Inophloeus), C. placidus (Broun, 1914) (from Nicaeana), C. posticalis (Broun, 1893) (from Irenimus), C. rhesus (Pascoe, 1875) (from Inophloeus), C. rubidus (Broun, 1881) (from Inophloeus), C. similis (Barratt & Kuschel, 1996) (from

  1. Nanoconfinement Effects in Catalysis

    Energy Technology Data Exchange (ETDEWEB)

    Kung, Harold H. [Northwestern Univ., Evanston, IL (United States)

    2016-09-19

    In this investigation, the unique properties that stem from the constrained environment and enforced proximity of functional groups at the active site were demonstrated for a number of systems. The first system is a nanocage structure with silicon-based, atom-thick shells and molecular-size cavities. The shell imparts the expected size exclusion for access to the interior cavity, and the confined space together with the hydrophobic shell strongly influences the stability of charged groups. One consequence is that the interior amine groups in a siloxane nanocage exhibit a shift in their protonation ability that is equivalent to about 4 pH units. In another nanocage structure designed to possess a core-shell structure in which the core periphery is decorated with carboxylic acid groups and the shell interior is populated with silanol groups, the restricted motion of the core results in limiting the stoichiometry of reaction between carboxylic acid and a Co2CO8 complex, which leads to formation and stabilization of Co(I) ions in the nanocage. The second designed catalytic structure is a supported, isolated, Lewis acid Sn-oxide unit derived from a (POSS)-Sn-(POSS) molecular complex (POSS = incompletely condensed silsesquioxane). The Sn center in the (POSS)-Sn-(POSS) complex is present in a tetrahedral coordination, as confirmed by single crystal x-ray crystallography and Sn NMR, and its Lewis acid character is demonstrated with its binding to amines. The retention of the tetrahedral coordination of Sn after heterogenization and mild oxidative treatment is confirmed by characterization using EXAFS, NMR, UV-vis, and DRIFT, and its Lewis acid character is confirmed by stoichiometric binding with pyridine. This Sn-catalyst is active in hydride transfer reactions as a typical solid Lewis acid. In addition, the Sn centers can also create Brønsted acidity with alcohol by binding the alcohol strongly as alkoxide and transferring the hydroxyl H to the

  2. (Sub)millimeter emission lines of molecules in born-again stars

    Science.gov (United States)

    Tafoya, D.; Toalá, J. A.; Vlemmings, W. H. T.; Guerrero, M. A.; De Beck, E.; González, M.; Kimeswenger, S.; Zijlstra, A. A.; Sánchez-Monge, Á.; Treviño-Morales, S. P.

    2017-04-01

    from other observations. We derived a rotational temperature of Trot = 13 ± 1 K, and a total column density of NHCN = 1.6 ± 0.1 × 1016 cm-2 for V4334 Sgr. This result sets a lower limit on the amount of hydrogen that was ejected into the wind during the born-again event of this source. For V605 Aql, we obtained a lower limit for the integrated line intensities I12CO/I13CO> 4. This publication is based on data acquired with the Atacama Pathfinder Experiment (APEX) and IRAM 30 m telescopes. APEX is a collaboration between the Max-Planck-Institut für Radioastronomie, the European Southern Observatory, and the Onsala Space Observatory. IRAM is supported by INSU/CNRS (France), MPG (Germany) and IGN (Spain).

  3. 1,3-dialkyl- and 1,3-diaryl-3,4,5,6-tetrahydropyrimidin-2-ylidene rhodium(i) and palladium(II) complexes: synthesis, structure, and reactivity.

    Science.gov (United States)

    Mayr, Monika; Wurst, Klaus; Ongania, Karl-Hans; Buchmeiser, Michael R

    2004-03-05

    The synthesis of novel 1,3-diaryl- and 1,3-dialkylpyrimidin-2-ylidene-based N-heterocyclic carbenes (NHCs) and their rhodium(i) and palladium(II) complexes is described. The rhodium compounds bromo(cod)[1,3-bis(2-propyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene]rhodium (7), bromo(cod)(1,3-dimesityl-3,4,5,6-tetrahydropyrimidin-2-ylidene)rhodium (8) (cod=eta(4)-1,5-cyclooctadiene, mesityl=2,4,6-trimethylphenyl), chloro(cod)(1,3-dimesityl-3,4,5,6-tetrahydropyrimidin-2-ylidene)rhodium (9), and chloro(cod)[1,3-bis(2-propyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene]rhodium (10) were prepared by reaction of [[Rh(cod)Cl](2)] with lithium tert-butoxide followed by addition of 1,3-dimesityl-3,4,5,6-tetrahydropyrimidinium bromide (3), 1,3-dimesityl-3,4,5,6-tetrahydropyrimidinium tetrafluoroborate (4), 1,3-di-2-propyl-3,4,5,6-tetrahydropyrimidinium bromide (6), and 1,3-di-2-propyl-3,4,5,6-tetrahydropyrimidinium tetrafluoroborate, respectively. Complex 7 crystallizes in the monoclinic space group P2(1)/n, and 8 in the monoclinic space group P2(1). Complexes 9 and 10 were used for the synthesis of the corresponding dicarbonyl complexes dicarbonylchloro(1,3-dimesityl-3,4,5,6-tetrahydropyrimidin-2-ylidene)rhodium (11), and dicarbonylchloro[1,3-bis(2-propyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene]rhodium (12). The wavenumbers nu(CO I)/nu(CO II) for 11 and 12 were used as a quantitative measure for the basicity of the NHC ligand. The values of 2062/1976 and 2063/1982 cm(-1), respectively, indicate that the new NHCs are among the most basic cyclic ligands reported so far. Compounds 3 and 6 were additionally converted to the corresponding cationic silver(i) bis-NHC complexes [Ag(1,3-dimesityl-3,4,5,6-tetrahydropyrimidin-2-ylidene)(2)]AgBr(2) (13) and [Ag[1,3-bis(2-propyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene](2)]AgBr(2) (14), which were subsequently used in transmetalation reactions for the synthesis of the corresponding palladium(II) complexes Pd(1,3-dimesityl-3,4,5,6-tetrahydropyrimidin-2

  4. Direct Detection of Polarized, Scattered Light from Exoplanets

    Science.gov (United States)

    Laughlin, Gregory

    super-Earth with the highest expected polarimetric signal-to- noise ratio. These exoplanets should all produce detectable polarization, and they present unique opportunities to study the atmospheres of wildly different exoplanets. Extending the PI s (Laughlin) Monte Carlo ray-tracing code, and utilizing the Co-I s (Fortney) experience in modeling exoplanet atmospheres, we propose to fund a graduate student to model the polarization data obtained from POLISH2 and invert the above variables. This is because they affect the amplitude and shape of the periodic variability in the polarization state of light from the system. Indeed, the discovery of spherical, sulfuric acid droplets suspended in the Venusian atmosphere was made forty years ago with Mie scattering models to fit polarimetric measurements. The PI s ray-tracing code, which has been used to model the rapid heating of the eccentric HD 80606b exoplanet, currently includes Rayleigh scattering and alkali metal absorption in a self-consistent manner. The direct detection of exoplanets as well as characterization of their atmospheric compositions and structure is directly related to the goals of the Origins program and to the NASA 2010 Science Plan, which emphasizes exploration of exoplanets and exoplanetary systems.

  5. Towards a Fundamental Understanding of Short Period Eclipsing Binary Systems Using Kepler Data

    Science.gov (United States)

    Prsa, Andrej

    -to-primary light ratio regime of ~1-2% for the circumbinary host system Kepler-16. Semi-detached binaries are ideal targets to study the dynamical processes such as mass flow and accretion, and the associated thermal processes such as intensity variation due to distortion of the lobe-filling component and material inflow collisions with accretion disks. Overcontact binaries are very abundant, yet their evolution and radiative properties are poorly understood and conflicting theories exist to explain their population frequency and structure. In addition, we will measure eclipse timing variations for all program binaries that attest to the presence of perturbing third bodies (stellar and substellar!) or dynamical interaction between the components. By a dedicated, detailed, manual modeling of these sets of targets, we will be able to use Kepler's ultra-high precision photometry to a rewarding scientific end. Thanks to the unprecedented quality of Kepler data, this will be a highly focused effort that maximizes the scientific yield and the reliability of the results. Our team has ample experience dealing with Kepler data (PI Prsa serves as chair of the Eclipsing Binary Working Group in the Kepler Science Team), spectroscopic follow-up (Co-Is Mahadevan and Bender both have experience with radial velocity instrumentation and large spectroscopic surveys), and eclipsing binary modeling (PI Prsa and Co-I Devinney both have a long record of theoretical and computational development of modeling tools). The bulk of funding we are requesting is for two postdoctoral research fellows to conduct this work at 0.5 FTE/year each, for the total of 2 years.

  6. Put X-Ray Polarimetry on the MAP!

    Science.gov (United States)

    Weisskopf, Martin C.

    2013-01-01

    With Prof. R. Novick and others at the Columbia Astrophysics Laboratory I help found the field of X-ray polarimetry in the early 1970s. Currently I have more experience with the design, construction, calibration, and space flight of such instruments than anyone on the planet. The early probing beginnings saw only one definitive measurement (that of the integrated low-energy X-ray emission from the Crab Nebula sans pulsar) and a number of upper limits. The limited success did nevertheless inspire a number of detailed theoretical calculations, concentrating at first on neutron stars and black holes showing how precise measurements (e.g. degree of polarization and position angle as a function of pulse phase) would provide definitive limitations on otherwise equally plausible theoretical models. Over time the theoretical foundation has grown (e.g. the proceedings of the X-Ray Polarimetry Workshop held at SLAC in 2004). I will outline these foundations. It is important to understand the history of X-ray polarimetry beyond the early excitement. A polarimeter was at the focus of the original Einstein mission but was dropped during the restructuring. A polarimeter was successfully proposed (R. Novick PI, I was a Co-I) and built for the original Spectrum-X mission. During the years before the cancellation of Spectrum-X, the potential flight of this device stood in the way of other space flights for polarimeters --- "let us wait and see what it finds". This was unfortunate as there were a number of reasons why that polarimeter should not have been flown on the mission. Perhaps the most significant (but not only) reason was that a shared focal plane provided very little observing time. This is an extremely important point in considering the Roadmap. It is doubtful that there many 100%-polarized sources and so the "signal" is more typically a small fraction of the source flux. Thus, the source itself provides a substantial background, making continuum polarimetry even more

  7. Preface: Phonons 2007

    Science.gov (United States)

    Perrin, Bernard

    2007-06-01

    were offered by C'Nano IdF (Centre de Compétence NanoSciences Ile-de-France/Paris District Competence Center in Nanosciences). I want also to point out the strong support given by three institutions: CNRS (Centre National de la Recherche Scientifique), INSP (Institut des NanoSciences de Paris) and SFA (Socitété Française d'Acoustique). Finally, I would like to thank the members of the different committees who helped for the organization of this conference. I am particularly indebted to Bernard Bonello, Arnaud Devos, Jean-Yves Duquesne, Jean-Yves Prieur and Clément Rossignol for their invaluable help. I appreciated the kindness and efficiency of Armelle Guilloux ('Ellipse & Co'). I want also to express my thanks to close collaborators: Catherine Dematteis, Agnès Huynh and Emmanuel Péronne. During the conference, I appreciated the valuable assistance of Sandrine Guit, Béatrice Desoudin and of the student team. The edition of these proceedings could not have been possible without the tremendous amount of work performed by Jean-Yves Duquesne and the valuable help of Jean-Yves Prieur. I hope that the delegates of PHONONS 2007 enjoyed the program and will be willing to attend the 13th conference which will be chaired by Professor Chi Kuang Sun in Taiwan in 2010. Bernard Perrin, Chairman of PHONONS 2007 Institut des NanoSciences de Paris, Paris, November 2007 Copyright: CNRS Photo - Nicole TIGET. The PDF contains the lists of committee members, sponsors and participants.

  8. Dust Measurements in the Coma of Comet 67P/Churyumov-Gerasimenko Inbound to the Sun Between 3.7 and 3.4 AU

    Science.gov (United States)

    Rotundi, Alessandra; Della Corte, Vincenzo; Fulle, Marco; Ferrari, Marco; Sordini, Roberto; Ivanovski, Stavro; Accolla, Mario; Lucarelli, Francesca; Zakharov, Vladimir; Mazzotta Epifani, Elena; López-Moreno, José J.; Rodríguez, Julio; Colangeli, Luigi; Palumbo, Pasquale; Bussoletti, Ezio; Crifo, Jean-Francois; Esposito, Francesca; Green, Simon F.; Grün, Eberhard; Lamy, Philippe L.

    2015-04-01

    data on grain speed and its optical cross section. The IS grain momentum measurement, when combined with the GDS detection time, provides a direct measurement of grain speed and mass. These combined measurements characterize single grain dust dynamics in the coma of 67P/CG. The first grain was detected on 1 August 2014 at 814 km from the comet nucleus. Between then and 13 Septem-ber 2014 GIADA detected 35 grains ranging in mass from ~ 5 x 10-10 to 8 x 10-8 kg. Including complementary data from the OSIRIS narrow angle camera, the dust mass loss was calculated over an additional three orders of magni-tude in mass, extending the ejected dust grain sizes up to 2 cm. Combined with data from the MIRO and the ROSINA instruments onboard Rosetta we find a dust/gas mass ratio of 4 +/- 2 averaged over the sunlit nucleus sur-face. The dust to gas ratio may change as the comet approaches closer to the Sun. Acknowledgments: GIADA was built by a consortium led by the Univ. Napoli "Parthenope" & INAF- Oss. Astr. Capodimonte, in collabo-ration with the Inst. de Astrofisica de Andalucia, Selex-ES, FI and SENER. GIADA is presently managed & operated by Ist. di Astrofisica e Planetologia Spaziali-INAF, IT. GIADA was funded and managed by the Agenzia Spaziale Italiana, IT, with the support of the Spanish Ministry of Education and Science MEC, ES. GIADA was developed from a PI proposal from the University of Kent; sci. & tech. contribution were pro-vided by CISAS, IT, Lab. d'Astr. Spat., FR, and Institutions from UK, IT, FR, DE and USA. We thank the RSGS/ESAC, RMOC/ESOC & Rosetta Project/ESTEC for their outstanding work. Science support provided was by NASA through the US Rosetta Project managed by the Jet Propulsion Laboratory/California Institute of Technology. GIADA calibrated data will be available through ESA's PSA web site(www.rssd.esa.int/index.php?project=PSA&page=in dex). We would like to thank Angioletta Coradini for her contribution as a GIADA Co-I. We thank the MIRO, OSIRIS and

  9. Magnified Weak Lensing Cross Correlation Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Ulmer, Melville P., Clowe, Douglas I.

    2010-11-30

    This project carried out a weak lensing tomography (WLT) measurement around rich clusters of galaxies. This project used ground based photometric redshift data combined with HST archived cluster images that provide the WLT and cluster mass modeling. The technique has already produced interesting results (Guennou et al, 2010,Astronomy & Astrophysics Vol 523, page 21, and Clowe et al, 2011 to be submitted). Guennou et al have validated that the necessary accuracy can be achieved with photometric redshifts for our purposes. Clowe et al titled "The DAFT/FADA survey. II. Tomographic weak lensing signal from 10 high redshift clusters," have shown that for the **first time** via this purely geometrical technique, which does not assume a standard rod or candle, that a cosmological constant is **required** for flat cosmologies. The intent of this project is not to produce the best constraint on the value of the dark energy equation of state, w. Rather, this project is to carry out a sustained effort of weak lensing tomography that will naturally feed into the near term Dark Energy Survey (DES) and to provide invaluable mass calibration for that project. These results will greatly advance a key cosmological method which will be applied to the top-rated ground-based project in the Astro2020 decadal survey, LSST. Weak lensing tomography is one of the key science drivers behind LSST. CO-I Clowe is on the weak lensing LSST committee, and senior scientist on this project, at FNAL James Annis, plays a leading role in the DES. This project has built on successful proposals to obtain ground-based imaging for the cluster sample. By 1 Jan, it is anticipated the project will have accumulated complete 5-color photometry on 30 (or about 1/3) of the targeted cluster sample (public webpage for the survey is available at http://cencos.oamp.fr/DAFT/ and has a current summary of the observational status of various clusters). In all, the project has now been awarded the equivalent of over 60

  10. Influence of Coronal Abundance Variations

    Science.gov (United States)

    Scargle, Jeffrey D. (Technical Monitor); Kashyap, Vinay

    2005-01-01

    The PI of this project was Jeff Scargle of NASA/Ames. Co-I's were Alma Connors of Eureka Scientific/Wellesley, and myself. Part of the work was subcontracted to Eureka Scientific via SAO, with Vinay Kashyap as PI. This project was originally assigned grant number NCC2-1206, and was later changed to NCC2-1350 for administrative reasons. The goal of the project was to obtain, derive, and develop statistical and data analysis tools that would be of use in the analyses of high-resolution, high-sensitivity data that are becoming available with new instruments. This is envisioned as a cross-disciplinary effort with a number of "collaborators" including some at SA0 (Aneta Siemiginowska, Peter Freeman) and at the Harvard Statistics department (David van Dyk, Rostislav Protassov, Xiao-li Meng, Epaminondas Sourlas, et al). We have developed a new tool to reliably measure the metallicities of thermal plasma. It is unfeasible to obtain high-resolution grating spectra for most stars, and one must make the best possible determination based on lower-resolution, CCD-type spectra. It has been noticed that most analyses of such spectra have resulted in measured metallicities that were significantly lower than when compared with analyses of high- resolution grating data where available (see, e.g., Brickhouse et al., 2000, ApJ 530,387). Such results have led to the proposal of the existence of so-called Metal Abundance Deficient, or "MAD" stars (e.g., Drake, J.J., 1996, Cool Stars 9, ASP Conf.Ser. 109, 203). We however find that much of these analyses may be systematically underestimating the metallicities, and using a newly developed method to correctly treat the low-counts regime at the high-energy tail of the stellar spectra (van Dyk et al. 2001, ApJ 548,224), have found that the metallicities of these stars are generally comparable to their photospheric values. The results were reported at the AAS (Sourlas, Yu, van Dyk, Kashyap, and Drake, 2000, BAAS 196, v32, #54.02), and at the

  11. ESA's XMM-Newton gains deep insights into the distant Universe

    Science.gov (United States)

    2003-07-01

    progress, first results seem to confirm that the number of clusters 7000 million years ago is little different from that of today. This behaviour is predicted by models of the Universe that expand forever and drive the galaxy clusters further and further apart. Eventually, it will be possible for the team to use their results to determine whether the expansion of the Universe is accelerating, as indicated by some other recent observations, or decelerating, as traditionally thought. Note to Editors: This is a coordinated ESA/ESO release. The presented results have been obtained by the XMM-LSS consortium, led by Service d'Astrophysique du CEA (France) and consisting of Co-I institutes from the United Kingdom, Ireland, Denmark, The Netherlands, Belgium, France, Italy, Germany, Spain and Chile. The home page of the XMM-LSS project can be found at: http://vela.astro.ulg.ac.be/themes/spatial/xmm/LSS/index_e.html This work is based on two papers to be published in the professional astronomy journal, Astronomy and Astrophysics (The XMM-LSS survey:I. Scientific motivations, design and first results by Marguerite Pierre et al., astro-ph/0305191 and The XMM-LSS survey:II. First high redshift galaxy clusters: relaxed and collapsing systems by Ivan Valtchanov et al.,astro-ph/0305192). More about XMM-Newton XMM-Newton can detect more X-ray sources than any previous satellite and is helping to solve many cosmic mysteries of the violent Universe, from black holes to the formation of galaxies. It was launched on 10 December 1999, using an Ariane-5 rocket from French Guiana. It is expected to return data for a decade. XMM-Newton's high-tech design uses over 170 wafer-thin cylindrical mirrors spread over three telescopes. Its orbit takes it almost a third of the way to the Moon, so that astronomers can enjoy long, uninterrupted views of celestial objects.

  12. Uptake of elements by fungi in the Forsmark area

    Energy Technology Data Exchange (ETDEWEB)

    Johanson, Karl J.; Nikolova, Ivanka; Taylor, Andy F.S. [Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Forest Mycology and Pathology; Vinichuk, Mykhaylo M. [Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Soil Sciences

    2004-10-01

    .4 in mycelium and 0.04 in fruit bodies. Cadmium was an element, which was taken up very efficiently by fungi. Concentration ratios for Cd were calculated to be 3.0 in mycelium and 5.8 in fruit bodies. Cortinarius armeniacus showed extremely high concentration ratio for Cd 33.3. Fungi did not accumulate iodine. Mercury was accumulated by some fungal species. Concentration ratios for Hg in mycelium were about 1.1, and in fruit bodies 1.5. High Hg accumulations were observed for litter decomposing fungus Collybia peronata (CR=11.7) and Sarcodon imbricatus (CR=9.2). We found no accumulation of Pb in fungal mycelium or in fruit bodies. Concentration ratios for Pb in mycelium were found to be 0.6, in fruit bodies 0.1, which indicates rather efficient exclusion of Pb from fungi. Exceptionally low thorium concentration was found in fungi indicating effective exclusion of Th from fruit bodies. Concentration ratios for the studied fungal species varied between 0.001 and 0.16. In fruit bodies of fungi uranium was found only as trace amounts 0.006 mg/kg, indicating rather low uptake rate and very efficient exclusion of U from fungi. Higher U concentration was observed in fruit body of Cortinarius odorifer 0.216 mg/kg. Phosphorus, Cd, Cu, Zn, Hg and As were accumulated mainly in fruit bodies of fungi. Concentrations of these elements were found to be higher in fruit bodies of fungi compared to that in mycelium, giving fruit bodies to mycelium concentration ratios 4.1, 2.2, 1.7, 1.4, 1.4 and 1.3 correspondingly. Highest preferences for accumulation of P within fruit bodies were shown by Lactarius scrobiculatus (CR=20.7), for Cd by Cortinarius armeniacus (CR=33.2), for Cu and Hg by litter decomposing fungus Collybia peronata (CR=7.2 and 11.7), for Zn by Sarcodon imbricatus (CR=8.4), for As by Collybia peronata and Cortinarius sp. (CR=7.1). Calcium, U, Th, Pb, Cr, Sr, Co, I, Ni and Mn showed higher concentrations in fungal mycelium, compared to concentrations in fruit bodies.

  13. Uptake of elements by fungi in the Forsmark area

    International Nuclear Information System (INIS)

    Johanson, Karl J.; Nikolova, Ivanka; Taylor, Andy F.S.; Vinichuk, Mykhaylo M.

    2004-10-01

    .4 in mycelium and 0.04 in fruit bodies. Cadmium was an element, which was taken up very efficiently by fungi. Concentration ratios for Cd were calculated to be 3.0 in mycelium and 5.8 in fruit bodies. Cortinarius armeniacus showed extremely high concentration ratio for Cd 33.3. Fungi did not accumulate iodine. Mercury was accumulated by some fungal species. Concentration ratios for Hg in mycelium were about 1.1, and in fruit bodies 1.5. High Hg accumulations were observed for litter decomposing fungus Collybia peronata (CR=11.7) and Sarcodon imbricatus (CR=9.2). We found no accumulation of Pb in fungal mycelium or in fruit bodies. Concentration ratios for Pb in mycelium were found to be 0.6, in fruit bodies 0.1, which indicates rather efficient exclusion of Pb from fungi. Exceptionally low thorium concentration was found in fungi indicating effective exclusion of Th from fruit bodies. Concentration ratios for the studied fungal species varied between 0.001 and 0.16. In fruit bodies of fungi uranium was found only as trace amounts 0.006 mg/kg, indicating rather low uptake rate and very efficient exclusion of U from fungi. Higher U concentration was observed in fruit body of Cortinarius odorifer 0.216 mg/kg. Phosphorus, Cd, Cu, Zn, Hg and As were accumulated mainly in fruit bodies of fungi. Concentrations of these elements were found to be higher in fruit bodies of fungi compared to that in mycelium, giving fruit bodies to mycelium concentration ratios 4.1, 2.2, 1.7, 1.4, 1.4 and 1.3 correspondingly. Highest preferences for accumulation of P within fruit bodies were shown by Lactarius scrobiculatus (CR=20.7), for Cd by Cortinarius armeniacus (CR=33.2), for Cu and Hg by litter decomposing fungus Collybia peronata (CR=7.2 and 11.7), for Zn by Sarcodon imbricatus (CR=8.4), for As by Collybia peronata and Cortinarius sp. (CR=7.1). Calcium, U, Th, Pb, Cr, Sr, Co, I, Ni and Mn showed higher concentrations in fungal mycelium, compared to concentrations in fruit bodies

  14. An Appraisal of Analytical Methods for Plutonium and their Applications to the Analysis of Nuclear Materials; Evaluation des Methodes Analytiques de Dosage du Plutonium et de Leur Application a l'Analyse des Matieres Nucleaires; Otsenka analiticheskikh metodov opredeleniya plutoniya i ikh primenenie dlya analiza yadernykh materialov; Metodos Analiticos de Determinacion del Plutonio y su Empleo en el Analisis de Materiales Nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Milner, G. W.C.; Phillips, G. [Atomic Energy Research Establishment, Harwell, Berks. (United Kingdom)

    1966-02-15

    hromatograficheskogo sposoba obratnoj fazy, prichem osoboe vnimanie obrashhaetsja na ih prigodnost' dlja radioaktivnyh obrazcov. Udeljaetsja vnimanie mnogim problemam, kotorye voznikajut pri uspeshnom primenenii jetih metodov dlja analiza splavov plutonija, keramiki i kermetov v razlichnyh sistemah, soderzhashhih uran, torij, zhelezo, hrom, molibden, cerij i kobal't. Opisyvajutsja trudnosti, voznikajushhie pri rastvorenii obrazcov i pri podgonke plutonija k trebuemomu sostojaniju valentnosti. V doklade na primerah kommentirujutsja sootvetstvujushhie preimushhestva rastvorenija v smesjah obychnyh mineral'nyh kislot s pomoshh'ju plavlenija. Izlagajutsja procedury s odnovremennym opisaniem analiticheskih rezul'tatov dlja tipichnyh obrazcov s cel'ju ispol'zovanija ih dlja analizov splavov Pu-U, Pu-Ce-Co i Pu-U-Mo, okisej i karbidov Pu-U karbidnyh kermetov Pu-U s dobavleniem Fe, M.o i Sg. Jeti materialy polucheny na osnove metallurgicheskih issledovanij i programmnyh razrabotok dlja novogo jadernogo topliva. (author)

  15. Svojstva i struktura wolframkarbid-kobalt prevlake deponovane plazma-sprej postupkom

    Directory of Open Access Journals (Sweden)

    Mihailo Rade Mrdak

    2013-10-01

    , 2011, (Turbojet engine-standard practices manuel TURBOMECA. Mikrostruktura svih prevlaka je lamelarna. Na mikrofotografijama se vidi da su istopljene čestice praha pravilno razlivene. Slojevi prevlake deponovani su kontinualno bez prisutnih mikro i makropukotina kroz slojeve. U slojevima nisu prisutne neistopljene čestice praha, precipitati i interlamelarne pore. U deponovanim slojevima svih prevlaka jasno se uočavaju ravnomerno distribuirane karbidne faze u žilavoj osnovi kobalta. Na svim mikrofotografijama jasno se uočavaju svetla polja metalnih faza i tamnosiva polja karbidnih faza. U svetlim poljima prisutna je polazna metalna faza Co i metalna faza W koja potiče od delimične razgradnje polaznog kubnog monocarbidea WC (Saha, et al., 2010, pp.592-595. U sivim poljima prisutna je polazna faza kubnog monokarbidea WC i karbidne faze koje su nastale razlaganjem kubnog karbida WC u karbide tipa W2C,W3C i mešoviti karbid ή - Co3W3C (Saha, et al., 2010, pp.592-595, (de Villiers Lovelock, 1998, pp.357–373. Zaključak Plazma-sprej postupkom (APS deponovane su prevlake WC17Co sa  protocima plazma gasa od 12 l/min, 22 l/min i 32 l/ min He. U radu su analizirane mehaničke karakteristike deponovanih slojeva i mikrostrukturne karakteristike na svetlosnom mikroskopu. Morfologija čestica praha ispitana je na (SEM skening elektronskom mikroskopu. Na osnovu izvršenih analiza došlo se do određenih zaključaka. Morfologija čestica praha WC17Co je sfernog oblika i tipična je za čestice praha koje se proizvode tehnikom  suvo  raspršavanje/sinterovanje. Vrednosti mikrotvrdoće i čvrstoće spoja deponovanih slojeva bili su u direktnoj vezi sa protocima helijuma kao plazma gasa. Svi deponovani slojevi imali su vrednosti mikrotvrdoće u propisanim granicama od 850 do 1300 HV0.3. Najravnomerniju raspodelu mikrotvrdoće imali su slojevi deponovani sa protokom plazma gasa od 22 l/min He.  Ti su slojevi imali najmanju razliku  mikrotvrdoće između maksimalnih i