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Sample records for sordan 70a northrup

  1. 33 CFR 110.70a - Northeast River, North East, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Northeast River, North East, Md. 110.70a Section 110.70a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.70a Northeast River, North East, Md. The water...

  2. GRAELLSIA 70 años después: la era digital

    Directory of Open Access Journals (Sweden)

    Martín Albaladejo, Carolina

    2014-12-01

    Full Text Available This article aims at commemorating the 70 years of existence of the journal Graellsia, recalling its inception, briefly describing its long career and welcoming its publication in digital format.En este artículo se pretende conmemorar los 70 años de existencia de la revista GRAELLSIA, evocando sus inicios, describiendo someramente su ya largo recorrido y dando la bienvenida a su publicación en formato digital.

  3. 77 FR 56909 - Culturally Significant Objects Imported for Exhibition Determinations: “Tokyo 1955-70: A New...

    Science.gov (United States)

    2012-09-14

    ... the Museum of Modern Art, New York, NY, from on or about November 18, 2012, until on or about February... ``Tokyo 1955-70: A New Avant-Garde,'' imported from abroad for temporary exhibition within the United...

  4. Arabidopsis EXO70A1 recruits Patellin3 to the cell membrane independent of its role as an exocyst subunit

    NARCIS (Netherlands)

    Wu, C.; Tan, L.; van Hooren, M.; Tan, X.; Liu, F.; Li, Y.; Zhao, Y.; Li, B.; Rui, Q.; Munnik, T.; Bao, Y.

    2017-01-01

    The exocyst is a well-known complex which tethers vesicles at the cell membrane before fusion. Whether an individual subunit can execute a unique function is largely unknown. Using yeast-two-hybrid (Y2H) analysis, we found that EXO70A1 interacted with the GOLD domain of Patellin3 (PATL3). The direct

  5. A honey bee hexamerin, HEX 70a, is likely to play an intranuclear role in developing and mature ovarioles and testioles.

    Directory of Open Access Journals (Sweden)

    Juliana R Martins

    Full Text Available Insect hexamerins have long been known as storage proteins that are massively synthesized by the larval fat body and secreted into hemolymph. Following the larval-to-pupal molt, hexamerins are sequestered by the fat body via receptor-mediated endocytosis, broken up, and used as amino acid resources for metamorphosis. In the honey bee, the transcript and protein subunit of a hexamerin, HEX 70a, were also detected in ovaries and testes. Aiming to identify the subcellular localization of HEX 70a in the female and male gonads, we used a specific antibody in whole mount preparations of ovaries and testes for analysis by confocal laser-scanning microscopy. Intranuclear HEX 70a foci were evidenced in germ and somatic cells of ovarioles and testioles of pharate-adult workers and drones, suggesting a regulatory or structural role. Following injection of the thymidine analog EdU we observed co-labeling with HEX 70a in ovariole cell nuclei, inferring possible HEX 70a involvement in cell proliferation. Further support to this hypothesis came from an injection of anti-HEX 70a into newly ecdysed queen pupae where it had a negative effect on ovariole thickening. HEX 70a foci were also detected in ovarioles of egg laying queens, particularly in the nuclei of the highly polyploid nurse cells and in proliferating follicle cells. Additional roles for this storage protein are indicated by the detection of nuclear HEX 70a foci in post-meiotic spermatids and spermatozoa. Taken together, these results imply undescribed roles for HEX 70a in the developing gonads of the honey bee and raise the possibility that other hexamerins may also have tissue specific functions.

  6. Engagement of Components of DNA-Break Repair Complex and NFκB in Hsp70A1A Transcription Upregulation by Heat Shock.

    Science.gov (United States)

    Hazra, Joyita; Mukherjee, Pooja; Ali, Asif; Poddar, Soumita; Pal, Mahadeb

    2017-01-01

    An involvement of components of DNA-break repair (DBR) complex including DNA-dependent protein kinase (DNA-PK) and poly-ADP-ribose polymerase 1 (PARP-1) in transcription regulation in response to distinct cellular signalling has been revealed by different laboratories. Here, we explored the involvement of DNA-PK and PARP-1 in the heat shock induced transcription of Hsp70A1A. We find that inhibition of both the catalytic subunit of DNA-PK (DNA-PKc), and Ku70, a regulatory subunit of DNA-PK holo-enzyme compromises transcription of Hsp70A1A under heat shock treatment. In immunoprecipitation based experiments we find that Ku70 or DNA-PK holoenzyme associates with NFκB. This NFκB associated complex also carries PARP-1. Downregulation of both NFκB and PARP-1 compromises Hsp70A1A transcription induced by heat shock treatment. Alteration of three bases by site directed mutagenesis within the consensus κB sequence motif identified on the promoter affected inducibility of Hsp70A1A transcription by heat shock treatment. These results suggest that NFκB engaged with the κB motif on the promoter cooperates in Hsp70A1A activation under heat shock in human cells as part of a DBR complex including DNA-PK and PARP-1.

  7. Sibelius: Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi / Michael Scott Rohan

    Index Scriptorium Estoniae

    Rohan, Michael Scott

    1996-01-01

    Sibelius: Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi. 1 CD Deutsche Grammophon 447 760-2GH (72 minutes: DDD)

  8. Laparoscopic cholecystectomy in patients over 70 years of age: review of 176 cases Colecistectomía laparoscópica en pacientes mayores de 70 años: nuestra experiencia en 176 casos

    Directory of Open Access Journals (Sweden)

    F. J. Pérez Lara

    2006-01-01

    Full Text Available Introduction: we assessed the results of laparoscopic cholecystectomy in 176 patients over the age of 70 years. Patients and methods: the study included all patients older than 70 years of age who underwent laparoscopic surgery cholelithiasis during the previous ten years. Variables studied included age, sex, type of operation (programmed/emergency, comorbidity, anesthetic risk, intraoperative cholangiography, conversion to open surgery, number of trocars, reoperation, residual choledocholithiasis, postoperative hospital stay, morbidity and mortality. Results: the study included 176 patients (23.29% men and 76.71% women. The mean age was 74.86 years. The mean hospital stay was 1.27 days, with 16.98% morbidity and 0.56% mortality. Conclusions: laparoscopic cholecystectomy is a safe procedure in older patients. It results in faster recovery, a shorter postoperative stay and lower rates of morbidity and mortality than open bile duct surgery.Objetivo: el objetivo de nuestro estudio es el de evaluar los resultados obtenidos en 176 pacientes mayores de 70 años intervenidos mediante colecistectomía laparoscópica. Pacientes y métodos: se incluyen en el estudio todos los pacientes mayores de 70 años diagnosticados de colelitiasis intervenidos por laparoscopia en los diez últimos años. Analizamos los siguientes parámetros: edad, sexo, tipo de intervención (programada/urgente, comorbilidad, riesgo anestésico, colangiografía intraoperatoria, conversión a cirugía abierta, número de trócares, reintervención, coledocolitiasis residual, estancia hospitalaria postoperatoria y morbimortalidad. Resultados: incluimos en el estudio un total de 176 pacientes, de los cuales el 23,29% son varones y 76,71%, tienen una edad media de 74.86 años. En los resultados globales la estancia media hospitalaria es de 1,27 días, morbilidad 16,98% y mortalidad de 0,57%. Conclusiones: la colecistectomía laparoscópica es un procedimiento seguro en pacientes mayores

  9. Tratamiento funcional de fracturas desplazadas de olecranon en pacientes mayores de 70 años. [Functional treatment of displaced olecranon fractures in patients older than 70 years old.

    Directory of Open Access Journals (Sweden)

    Gerardo Gallucci

    2015-06-01

    Full Text Available Objetivo Reportar los resultados clínicos y radiológicos del tratamiento funcional de fracturas desplazadas de olécranon en pacientes >70 años. Material y Métodos Se evaluaron 28 pacientes >70 años con fracturas desplazadas de olécranon. El tratamiento consistió en la inmovilización inicial con una valva de yeso (promedio 5 días y, luego, movilización activa según tolerancia. No se indicó rehabilitación kinesiológica. Ningún paciente fue perdido en el seguimiento. El grupo estaba formado por 27 mujeres y un hombre. La edad promedio era de 82 años. Según la clasificación de la Clínica Mayo, 18 fracturas eran de tipo IIA y 10, de tipo IIB. El seguimiento promedio fue de 14 meses. Resultados La flexo-extensión fue de 142°-15°. La fuerza muscular fue de M5 en 17 pacientes y de M4 en 9. La fuerza de puño fue un 93% del lado contralateral. El dolor según la escala visual analógica fue de 1. La satisfacción con el tratamiento según esta escala fue de 9. Según el puntaje de la Clínica Mayo, 22 pacientes tuvieron resultados excelentes y 6, buenos. El puntaje DASH promedio fue de 15. Veinticuatro pacientes evolucionaron hacia la seudoartrosis. El gap articular final fue, en promedio, de 16 mm. El gap a nivel de la cortical posterior final fue, en promedio de 22 mm. Conclusión El tratamiento no quirúrgico de las fracturas desplazadas de olécranon en pacientes mayores ofrece un nú- mero elevado de buenos resultados funcionales con alto grado de satisfacción. Palabras clave: Fractura de olécranon. Fractura de codo. Tratamiento funcional.

  10. Proyecto de actividades físico recreativas para propiciar la incorporación de los adultos mayores de 65 a 70 años del Consejo Comunal La Libertad del Municipio Guacara

    Directory of Open Access Journals (Sweden)

    María Cristina Delgado Kessell

    2011-06-01

    Full Text Available En el siguiente trabajo pretendemos realizar un diagnóstico del grupo de adulto mayor, perteneciente al sector La Libertad del municipio Guacara, estado Carabobo. El mismo se basa en un proyecto de actividades para la incorporación de los adultos mayores de 65 a 70 años de edad de dicha comunidad. En este trabajo es de interés formular ciertas ideas que puedan fundamentar el impacto causado por la misión de Barrio Adentro Deportivo como programa priorizado para el desarrollo social de la República Bolivariana de Venezuela. El estudio permite explicar la característica del grupo desde diferentes puntos de vista y las posibles acciones a desarrollar, como estrategia para lograr una mejor participación en las actividades físico-recreativas de los adultos mayores y mejorar la calidad de vida de este grupo etáreo. Por lo que surge como problema. ¿Cómo propiciar la incorporación de los adultos mayores en las actividades físicas recreativas del círculo de abuelos de La Libertad? La investigación ofrece un referente para el estudio socio demográfico de la comunidad y el grupo teniendo en cuenta métodos de intervención comunitaria.

  11. 70 A TRILOGY OF PHILOSOPHY, LANGUAGE AND NATIONAL ...

    African Journals Online (AJOL)

    atrophy of a people's values and a fortiori to the degradation of our humanity. ... rate, the level of life expectancy, the level of school enrolment, the level of industrial production .... Although philosophical theories and systems are products of ...

  12. El modelo español de reconocimiento médico y psicotécnico en el contexto de 2ª Directiva (91/439/CEE: Resultados al ser aplicado sobre un grupo específico de conductores (45 a 70 años

    Directory of Open Access Journals (Sweden)

    Montoro González Luis

    2003-01-01

    Full Text Available Fundamento: Con la Directiva 91/439/CEE se inició lo que en un futuro será el permiso de conducir comunitario. Ahora bien, en el momento actual existen diferencias en cuanto a las condiciones de aptitud y a los periodos de prórroga del mismo. El presente estudio ofrece los resultados del reconocimiento médico y psicotécnico realizado a 606 conductores. Métodos: 606 conductores que reunían las siguientes características: edad entre 45 y 70 años, revisan el permiso del grupo 1 (B; hombres y mujeres; y finalmente, el periodo de prorroga es < 5 años. Posteriormente, se hace un seguimiento de los que, siendo aptos, regresan al centro y de esta manera podemos comprobar si existen modificaciones en cuanto al resultado del reconocimiento. Resultados: El 86,47% fueron aptos, un 12,21% aptos con restricción y un 1,65% no aptos. Por grupos de edad se apreció que a medida que avanza la edad disminuye el porcentaje de aptos y aumenta el de aptos con restricción (de 45-49 años hay un 93,19% de aptos, mientras que en el grupo de 65-69 se sitúa en un 67,35%. A los 5 años, un 11,13% de los conductores aptos habían modificado su condición (9,98% aptos con restricción; 1,15% no aptos, apreciándose que por grupos de edad también existen diferencias significativas (en el grupo de 45-49 años modifican su condición un 6,8%, mientras que en el de 65-69 lo hace un 18,1%. Conclusiones: De esta manera, podemos decir que existen diferencias entre las distintas edades y las condiciones de aptitud para la conducción, y también que un porcentaje significativo de conductores aptos modifica su condición de aptitud transcurridos al menos 5 años.

  13. William Allen Miller (1817-70): a distinguished scientist re-discovered.

    Science.gov (United States)

    Ashley-Miller, Michael

    2008-11-01

    Dr William Allen Miller developed an early interest in science and astronomy at secondary school. Although qualifying in medicine, he pursued a career in Chemistry at King's College, London. A particular interest in spectrum analysis led to a collaboration with Dr Huggins in examining the spectra of stars. For this work they each received the Gold Medal of the Royal Astronomical Society. His subsequent work at King's College, the Royal Society, the Courts of Law and for various Government enterprises earned him an outstanding scientific and advisory reputation.

  14. SU-E-T-70: A Radiobiological Model of Reoxygenation and Fractionation Effects

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero, M [University of Maryland School of Medicine, Baltimore, MD (United States); Carlson, DJ [Yale Univ. School of Medicine, New Haven, CT (United States)

    2015-06-15

    Purpose: To develop a simple reoxygenation model that fulfills the following goals:1-Quantify the reoxygenation effect in biologically effective dose (BED) and compare it to the repopulation effect.2-Model the hypoxic fraction in tumors as a function of the number of fractions.3-Develop a simple analytical expression for a reoxygenation term in BED calculations. Methods: The model considers tumor cells in two compartments: one normoxic population of cells and one hypoxic compartment including cells under a range of reduced oxygen concentrations. The surviving fraction is predicted using the linear-quadratic (LQ) model. A hypoxia reduction factor (HRF) is used to quantify reductions in radiosensitivity parameters α-A and β-A as cellular oxygen concentration decreases. The HRF is defined as the ratio of the dose at a specific level of hypoxia to the dose under fully aerobic conditions to achieve equal cell killing. The model assumes that a fraction of the hypoxic cells ( ) moves from the hypoxic to the aerobic compartment after each daily fraction. As an example, we consider standard fractionation for NSCLC (d=2Gy,n=33) versus a SBRT (n=5, d=10Gy) fractionation and compare the loss in reoxygenation biological effect with the gain in repopulation biological effect. Results: An analytic expression for the surviving fraction after n daily treatments is derived and the reoxygenation term in the biological effect is calculated. Reoxygenation and repopulation effects are the same order of magnitude for potential doubling time Td values of 2 to 5 days. The hypoxic fraction increases or decreases with n depending on the reoxygenation rate Δ. For certain combinations of parameters, the biological effect of reoxygenation goes as -(n-1)*ln(1-Δ) providing a simple expression that can be introduced in BED calculations. Conclusion: A novel radiobiological model was developed that can be used to evaluate the effect of reoxygenation in fractionated radiotherapy.

  15. La guerra civil. 70 años para luchar contra el olvido.

    OpenAIRE

    Rivas, Laura

    2006-01-01

    : Editorial: El emblemático número tres. Por: Ruiz Calderón, Humberto Especial Jóvenes, alcohol y ¿salud?. Venezuela, penoso liderazgo: consumo de licor y muertes en percances viales. Por: González, Silvia Lidia ¡Cuidado! ebrio al volante. Artículo Bebiendo el futuro. Por: Morales, Nelson Guía Web Sitios sobre alcoholismo en Internet. Historias El rostro más especial de Venezuela. Jacqueline Saburido. Por: González, Silvia Lidia Hora libre...

  16. Accounting for Money. Supervising: Economic and Financial Aspects. The Choice Series #70. A Self Learning Opportunity.

    Science.gov (United States)

    Bainbridge, Dennis

    This student guide is intended to assist persons employed as supervisors in accounting for money. Discussed in the first four sections are the following topics: the need for accounts; financial accounting (basics of financial accounting, creditors and debtors, assets and liabilities, and balance sheets); cost and management accounting (company,…

  17. Genetics Home Reference: tuberous sclerosis complex

    Science.gov (United States)

    ... 42. Citation on PubMed Northrup H, Koenig MK, Pearson DA, Au KS. Tuberous Sclerosis Complex. 1999 Jul ... Tuberous sclerosis complex: advances in diagnosis, genetics, and management. J Am Acad Dermatol. 2007 Aug;57(2): ...

  18. 75 FR 27419 - Airworthiness Directives; BAE Systems (Operations) Limited Model BAe 146 and Avro 146-RJ70A, 146...

    Science.gov (United States)

    2010-05-17

    ... visual inspection and a visual inspection; Method 2 is a detailed visual inspection. You may obtain.... registry. We also estimate that it will take about 12 work-hours per product to comply with the basic... inspection methods: Method 1 is a combination of a detailed visual inspection and a visual inspection; Method...

  19. 75 FR 1560 - Airworthiness Directives; BAE Systems (Operations) Limited Model BAe 146 and Avro 146-RJ70A, 146...

    Science.gov (United States)

    2010-01-12

    ... alternative inspection methods: Method 1 is a combination of a detailed visual inspection and a visual inspection; Method 2 is a detailed visual inspection. You may obtain further information by examining the... would take about 12 work-hours per product to comply with the basic requirements of this proposed AD...

  20. COMBINE7.0 - A Portable ENDF/B-VII.0 Based Neutron Spectrum and Cross-Section Generation Program

    Energy Technology Data Exchange (ETDEWEB)

    Woo Y. Yoon; David W. Nigg

    2008-09-01

    COMBINE7.0 is a FORTRAN 90 computer code that generates multigroup neutron constants for use in the deterministic diffusion and transport theory neutronics analysis. The cross-section database used by COMBINE7.0 is derived from the Evaluated Nuclear Data Files (ENDF/B-VII.0). The neutron energy range covered is from 20 MeV to 1.0E-5 eV. The Los Alamos National Laboratory NJOY code is used as the processing code to generate a 167 finegroup cross-section library in MATXS format for Bondarenko self-shielding treatment. Resolved resonance parameters are extracted from ENDF/B-VII.0 File 2 for a separate library to be used in an alternate Nordheim self-shielding treatment in the resolved resonance energy range. The equations solved for energy dependent neutron spectrum in the 167 fine-group structure are the B-3 or B-1 approximations to the transport equation. The fine group cross sections needed for the spectrum calculation are first prepared by Bondarenko selfshielding interpolation in terms of background cross section and temperature. The geometric lump effect, when present, is accounted for by augmenting the background cross section. Nordheim self-shielded fine group cross sections for a material having resolved resonance parameters overwrite correspondingly the existing self-shielded fine group cross sections when this option is used. The fine group cross sections in the thermal energy range are replaced by those selfshielded with the Amouyal/Benoist/Horowitz method in the three region geometry when this option is requested. COMBINE7.0 coalesces fine group cross sections into broad group macroscopic and microscopic constants. The coalescing is performed by utilizing fine-group fluxes and/or currents obtained by spectrum calculation as the weighting functions. The multigroup constant may be output in any of several standard formats including ANISN 14** free format, CCCC ISOTXS format, and AMPX working library format. ANISN-PC, a onedimensional, discrete-ordinate transport code, is incoprated into COMBINE7.0. As an option, the 167 fine-group constants generated by COMBINE portion in the program can be used to cacluate regionwise spectra in the ANISN portion, all internally to reflect the one-dimensional transport correction. Results for the criticality validation calculations are included as a part of verification and validation.

  1. COMBINE7.0 - A Portable ENDF/B-VII.0 Based Neutron Spectrum and Cross-Section Generation Program

    International Nuclear Information System (INIS)

    Yoon, Woo Y.; Nigg, David W.

    2008-01-01

    COMBINE7.0 is a FORTRAN 90 computer code that generates multigroup neutron constants for use in the deterministic diffusion and transport theory neutronics analysis. The cross-section database used by COMBINE7.0 is derived from the Evaluated Nuclear Data Files (ENDF/B-VII.0). The neutron energy range covered is from 20 MeV to 1.0E-5 eV. The Los Alamos National Laboratory NJOY code is used as the processing code to generate a 167 finegroup cross-section library in MATXS format for Bondarenko self-shielding treatment. Resolved resonance parameters are extracted from ENDF/B-VII.0 File 2 for a separate library to be used in an alternate Nordheim self-shielding treatment in the resolved resonance energy range. The equations solved for energy dependent neutron spectrum in the 167 fine-group structure are the B-3 or B-1 approximations to the transport equation. The fine group cross sections needed for the spectrum calculation are first prepared by Bondarenko selfshielding interpolation in terms of background cross section and temperature. The geometric lump effect, when present, is accounted for by augmenting the background cross section. Nordheim self-shielded fine group cross sections for a material having resolved resonance parameters overwrite correspondingly the existing self-shielded fine group cross sections when this option is used. The fine group cross sections in the thermal energy range are replaced by those selfshielded with the Amouyal/Benoist/Horowitz method in the three region geometry when this option is requested. COMBINE7.0 coalesces fine group cross sections into broad group macroscopic and microscopic constants. The coalescing is performed by utilizing fine-group fluxes and/or currents obtained by spectrum calculation as the weighting functions. The multigroup constant may be output in any of several standard formats including ANISN 14** free format, CCCC ISOTXS format, and AMPX working library format. ANISN-PC, a onedimensional, discrete-ordinate transport code, is incoprated into COMBINE7.0. As an option, the 167 fine-group constants generated by COMBINE portion in the program can be used to cacluate regionwise spectra in the ANISN portion, all internally to reflect the one-dimensional transport correction. Results for the criticality validation calculations are included as a part of verification and validation.

  2. Design package for concentrating solar collector panels

    Energy Technology Data Exchange (ETDEWEB)

    1978-08-01

    Information used to evaluate the design of the Northrup concentrating collector is presented. Included are the system performance specifications, the applications manual, and the detailed design drawings of the collector. The Northrup concentrating solar collector is a water/glycol/working fluid type, dipped galvanized steel housing, transparent acrylic Fresnel lens cover, copper absorber tube, fiber glass insulation and weighs 98 pounds. The gross collector area is about 29.4/sup 2/ per collector. A collector assembly includes four collector units within a tracking mount array.

  3. Arabidopsis exocyst subunits SEC8 and EXO70A1 and exocyst interactor ROH1 are involved in the localized deposition of seed coat pectin

    Czech Academy of Sciences Publication Activity Database

    Kulich, I.; Cole, R.; Drdová, Edita; Cvrčková, F.; Soukup, A.; Fowler, J.; Žárský, Viktor

    2010-01-01

    Roč. 188, č. 2 (2010), s. 615-625 ISSN 0028-646X R&D Projects: GA MŠk ME 841; GA MŠk(CZ) LC06034 Institutional research plan: CEZ:AV0Z50380511 Keywords : Arabidopsis * cell wall * exocyst Subject RIV: EF - Botanics Impact factor: 6.516, year: 2010

  4. Comentario a la presentación del libro "70 años del Cáncer en Colombia" del Académico Efraim Otero Ruiz

    Directory of Open Access Journals (Sweden)

    Alfonso Latiff Conde

    2002-08-01

    Full Text Available

    Estoy maravillado con el monumental esfuerzo y trabajo de Efraim Otero-Ruiz en la producción de su portentoso libro “Setenta años del cáncer en Colombia”.

    Escrito en una prosa amena y armoniosa, su lectura es verdadero deleite intelectual para quien sigue la apasionante madeja que constituye toda la trama inicial y que envuelve la concepción, el nacimiento y el desarrollo de una institución para el tratamiento del cáncer en Colombia.

    Es apasionante la forma como Efraim toma el hilo de la historia desde sus primeras y más importantes incepciones.

    Es sin duda Claudio Regaud, Jefe del Laboratorio de Radiofisiología del Instituto de Radium de París, la figura clave en la iniciativa de creación de un Instituto de Radium en Colombia. Alfonso Esguerra Gómez, becario de la Institución adquiere una valiosa experiencia en el tratamiento de tumores superficiales de cara y cuello y descubre la famosa pasta Colombia que permite amoldarse sobre la piel mientras en su interior se colocan las agujas de radium.

    En la década de los veinte Regaud se convierte en la figura más prestante en el mundo en el manejo del radium y es invitado universalmente para comunicar no solo sus experiencias sino como consejero y orientador de la creación de institutos de radium en el mundo.

    La invitación a Regaud en 1928 para visitar el Perú es conocida por Alfonso Esguerra y allí por primera vez se organiza un movimiento de influencias que con agudo análisis describe Efraim Otero, para movilizar todas las fuerzas académicas y políticas con el fin de aprovechar esta oportunidad y obtener la visita de Regaud a Colombia.

    En varias ocasiones en el futuro, circunstancias similares harán necesaria la influencia de médicos, no solo eminentes sino dotados de excelentes conexiones sociales y políticas para crear el Instituto Nacional de Radium.

    Efraím se introduce por todos los vericuetos académicos, científicos, políticos, económicos, lazos familiares, para poner en evidencia todos los esfuerzos que fueron necesarios para la realización del proyecto.

    Eminentes profesores y médicos se distinguen por su especial interés en el Instituto: José Vicente Huertas, Pompilio Martínez, Jaime Jaramillo Arango, Daniel Brigard, Ruperto Iregui, Juan Pablo Llinás, Alfonso Flórez y por supuesto los hermanos Esguerra Gómez, Alfonso y Gonzalo.

    Entre 1929 y 1933, la agitación política y la gran “crisis mundial” o “gran depresión” producen una gran incertidumbre entre los forjadores del Instituto Nacional de Radium. Esteban Jaramillo se enfrenta a la grave situación económica. En 1932 surge el conflicto con el Perú. Estos son años perdidos para la iniciación del proyecto.

    En 1933 se crea por decreto presidencial de Enrique Olaya Herrera una junta, que de ahora en adelante llamaremos “la junta” presidida por el Ministro de Hacienda y Crédito Público Esteban Jaramillo y los médicos Huertas, Jaramillo Arango, Iriarte, Iregui y Llinás, para adelantar el proyecto.

    El Ministro Jaramillo reúne la junta y un grupo de banqueros para estudiar la utilización de los fondos del “empréstito patriótico” del conflicto con el Perú.

    Con meticuloso estudio de los hechos, Efraim analiza los factores adversos que se desarrollan durante la gran crisis y apartándose transitoriamente de la evolución del proyecto analiza la actuación de Esteban Jaramillo para explicar cómo Colombia logra sortear situación tan angustiosa. Lección para los días que corren.

    La Junta comisiona a Daniel Brigard, Juan Pablo Llinás, Ruperto Iregui y Alfonso Flórez, Jefes de Sección, para que se trasladen a los Estados Unidos y Europa con el fin de que efectúen estudios técnicos de especialización, organización y dotación.

    Constituyeron el grupo de becarios que llevó a cabo esta excelente labor. La correspondencia que Efraim produce menciona una campaña soterrada contra la Junta y los promotores del Instituto.

    Una actitud fría de Regaud con uno de los comisionados hace pensar que la campaña llegó hasta París.

    Finalmente el 4 de agosto el Presidente Enrique Olaya Herrera inaugura, con un elocuente discurso improvisado, el Instituto Nacional de Radium, en el edificio construido por el arquitecto Pablo de la Cruz, en la calle 1ª # 8-95.

    Imagino las horas interminables que debieron tomarle a Efraim organizar tan monstruosa cantidad de documentos que logró allegar para escribir esta historia del Instituto de Cancerología que es la historia del Cáncer en Colombia...

  5. Determination of 6258-70, a new semi-synthetic taxane, in rat plasma and tissues: Application to the pharmacokinetics and tissue distribution study

    Directory of Open Access Journals (Sweden)

    Simin Zhao

    2016-08-01

    Full Text Available Cancer is the leading cause of death all over the world. Among the chemotherapy drugs, taxanes play an important role in cancer treatment. 6258-70 is a new semi-synthetic taxane which has a broad spectrum of antitumor activity. A fast and reliable high performance liquid chromatography-tandem mass spectrometry (HPLC–MS/MS method was developed for quantification of 6258-70 in rat plasma and tissues in this paper. After extraction by liquid-liquid extraction method with methyl tert-butyl ether, the samples were separated on a Kinetex C18 column (50 mm×2.1 mm, 2.6 µm, Phenomenex, USA within 3 min. The method was fully validated with the matrix effect between 87.7% and 99.5% and the recovery ranging from 80.3% to 90.1%. The intra- and inter-day precisions were less than 9.5% and the accuracy ranged from −3.8% to 6.5%. The reliable method was successfully applied to the pharmacokinetics and tissue distribution studies of 6258-70 after intravenous administration in rats. The pharmacokinetic results indicated that the pharmacokinetic behavior of 6258-70 in rats was in accordance with linear features within tested dosage of 1 to 4 mg/kg, and there was no significant difference between the two genders. The tissue distribution study showed that 6258-70 had an effective penetration, spread widely and rapidly and could cross blood-brain barrier. The results of pharmacokinetics and tissue distribution may provide a guide for future study.

  6. Pelvic tomo-therapy among 70 to 90 year old patients: feasibility and tolerance; Tomotherapie pelvienne chez les sujets ages de 70 a 90 ans: faisabilite et tolerance

    Energy Technology Data Exchange (ETDEWEB)

    Bibault, J.E.; Nickers, P.; Castelain, B.; Lacornerie, T.; Reynaert, N.; Lartigau, E. [Centre Oscar-Lambret, 59 - Lille (France)

    2010-10-15

    As population is getting older (the number of people older than 70 years will double by 2030), it is important to assess the feasibility and tolerance of new irradiation techniques, notably the intensity-modulated radiotherapy, for elderly people, particularly in the case of pelvic tumours. Based on a sample of 18 patients, the authors notice that tomo-therapy reduces the digestive and urinary toxicity, and thus could be used for the treatment of aged patients, even 80 to 90 year old patients in good general status. However, these results need to be confirmed by a study on a larger scale. Short communication

  7. Los procesos de domesticación vegetal y animal : Un aporte a la discusión argentina en los últimos 70 años

    OpenAIRE

    Yacobaccio, Hugo; Korstanje, M. Alejandra

    2007-01-01

    En este trabajo se pasa revista a los estudios sobre domesticación vegetal y animal en la arqueología argentina, se plantea su estado actual y las perspectivas futuras. Se discuten, asimismo, diversos aspectos teóricos vinculados a la domesticación, incluyendo el concepto mismo, y se evalúa la evidencia disponible hasta hoy en día. Sociedad Argentina de Antropología

  8. 77 FR 13141 - Notice of Intent To Prepare a Master Leasing Plan, Amendments to the Resource Management Plans...

    Science.gov (United States)

    2012-03-05

    ... Northrup, Project Manager, BLM Moab Field Office, 82 East Dogwood, Moab, UT 84532, telephone (435) 259-2151... Instruction Memorandum No. 2010-117. The MLP process will provide additional planning and analysis for areas... with varying mitigation levels for leasing. The planning area covers about 783,000 acres in east...

  9. The Deep Ocean Sound Channel in Areas Around Australia,

    Science.gov (United States)

    1980-10-01

    UNCLASSIFIED MRL-R-788 NLEEEEEE/llE/hm/l EIIEIIIEIIIII MRL-R-788 .0 -* AUSTRALIA LI, DEPARTMENT OF DEFENCE DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION...cumbersome, even though they do give accurate results. An over-simplified but enlight - ening sound speed equation, extensively used by Northrup and Colburn [13

  10. Application of an In-Line Contamination Monitoring Unit to the AHT-64 Hydraulic Test Stand.

    Science.gov (United States)

    1981-06-04

    suction return connection port will require the operator to secuire same from a squatting position. The present stowage arrangement on the test stand... SPC FC sample~~~ Iepal" -a *Tpoa _______Rate 7 eo3,t Sq,’ TPc owe te - U Enciosure ULeeds & Northrup N’AFC- 92- 1 0 Typical Plumbing Connections for

  11. Fuel shipment experience, fuel movements from the BMI-1 transport cask

    International Nuclear Information System (INIS)

    Bauer, Thomas L.; Krause, Michael G.

    1986-01-01

    The University of Texas at Austin received two shipments of irradiated fuel elements from Northrup Aircraft Corporation on April 11 and 16, 1985. A total of 59 elements consisting of standard and instrumented TRIGA fuel were unloaded from the BMI-1 shipping cask. At the time of shipment, the Northrup core burnup was approximately 50 megawatt days with fuel element radiation levels, after a cooling time of three months, of approximately 1.75 rem/hr at 3 feet. In order to facilitate future planning of fuel shipment at the UT facility and other facilities, a summary of the recent transfer process including several factors which contributed to its success are presented. Numerous color slides were made of the process for future reference by UT and others involved in fuel transfer and handling of the BMI-1 cask

  12. Design package for concentrating solar collector panels

    Science.gov (United States)

    1978-01-01

    Information used to evaluate the design of the Northrup concentrating collector is presented. Included are the system performance specifications, the applications manual, and the detailed design drawings of the collector. The collector is a water/glycol/working fluid type, with a dipped galvanized steel housing, transparent acrylic Fresnel lens cover, copper absorber tube, and fiber glass insulation. It weights 98 pounds. A collector assembly includes four collector units within a tracking mount array.

  13. Development and fabrication of a concentrating solar collector subsystem (quarterly reports)

    Energy Technology Data Exchange (ETDEWEB)

    1978-07-01

    Work done from January 1, 1978 through June 30, 1978, including several types of testing and results and evaluation of the structural design of the Northrup ''ML Series'' Concentrating Solar Collector, Model NSC-01-0732 and the Attitude Control System is reported. Efficiency tests, stagnation--defocusing tests, internal vacuum tests, pressure tests, tracking tests, fluttering tests, accelerated swivel and flexible joint life tests, and certification are described.

  14. Artificial Intelligence/Robotics Applications to Navy Aircraft Maintenance.

    Science.gov (United States)

    1984-06-01

    Northrup, Martin-Marietta, Rand, Perceptronics, PAR, Unilever , and » Philips. Japanese companies include Hitachi, Kawasaki, Fujitsu, NTT, NEC...in which computer systems have been configured. Another commercial development has also attracted attention. The General Electric Company is...increases the contrast to make dark objects in the scene stand out against a light background (or vice versa). Finally, it applies various simple and

  15. Hi-Tek Learning Strategies

    OpenAIRE

    Victor Selman; Jerry Selman

    2011-01-01

    Unorthodox ways currently used in colleges to accelerate the velocity of learning are reviewed. To augment persuasion and articulation ability of business school students, stand-up comedy is used (University of Chicago). Song writing, storytelling and improvisation (VanderbiltUniversity-Owens Management), and for Shakespearean motivation for other management skills at the corporate execu-tive level (Northrup Grumman). Food chow-down, before and during classes, including pizza and chocolate ca...

  16. Automatic Strain-Rate Controller,

    Science.gov (United States)

    1976-12-01

    D—AO37 9~e2 ROME AIR DEVELOPMENT CENTER GRIFFISS AFB N 1’ FIG 13/ 6AUTOMATIC STRAIN—RATE CONTROLLER, (U) DEC 76 R L HUNTSINGER. J A ADAMSK I...goes to zero. CONTROLLER, Leeds and Northrup Series 80 CAT with proportional band , rate , reset, and approach controls . Input from deviation output...8) through ( 16) . (8) Move the set-point slowl y up to 3 or 4. (9) If the recorder po inter hunts , adjust the func t ion controls on tine Ser

  17. Browse Author Index

    African Journals Online (AJOL)

    Items 101 - 150 of 151 ... A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All. N. Nordhagen, ØM · Northrup-Lyons, M · Noutfia, Y · Novakofski, CK · Nsiah, M · Nsue-Milang, D · Ntawuruhunga, P · Nti, AC · Ntwenya, J · Ntwenya, JG · Nutti, M · Nwachukwu, I.N · Nwachukwu, IN · Nwanze, PI · Nwaoguala, CNC · Nwaojigwa ...

  18. Socialistická propagace - reklama v podmínkách centrálně plánovaného hospodářství v Československu 70. a 80. let 20.století

    OpenAIRE

    Šimečková, Barbora

    2012-01-01

    This bachelor thesis analyses the theory and practice of socialistic advertising in the 70s and 80s od the 20th century in Czechoslovakia. The first part is based on current theories of advertising -- it analysis on the basis of of contemporary theoretical literature (textbooks for students of the Faculty of Journalism at Charles University in Prague, the magazin "Propagace") with theoretical approaches to advertising in the 70s and 80s of the last century in Czechoslovakia. The thesis states...

  19. Ustanovený řád. Koncept morového řádu pro Čechy v kontextu normativních textů střední Evropy z přelomu 70. a 80. let 17. století

    Czech Academy of Sciences Publication Activity Database

    Jirková, Pavla

    2016-01-01

    Roč. 31, č. 1 (2016), s. 25-51 ISSN 0231-7494 R&D Projects: GA ČR GA13-35304S Institutional support: RVO:67985998 Keywords : plague epidemics * infection rules * normative texts Subject RIV: AH - Economics

  20. La defensa de presos políticos a comienzos de los ´70: ejercicio profesional, derecho y política A defesa dos presos políticos no início dos anos 70: a prática profissional, o direito ea política The defense of political prisoners in the early '70s: professional practice, law and politics

    OpenAIRE

    Mauricio Chama

    2010-01-01

    El trabajo aborda la relación entre abogacía y política a comienzos de la década del '70. Más precisamente se propone identificar y reconstruir los principales rasgos que asume la defensa de presos políticos en ese período. Más que una labor específica, se entiende que la defensa de presos políticos en esos años representó una novedosa configuración que logró articular una nueva asociación de profesionales del derecho, renovadas estrategias de defensa, una vasta y sistemática labor de denunci...

  1. Separation of krypton and xenon from the offgas of nuclear facilities

    International Nuclear Information System (INIS)

    Ammon, R. von; Bumiller, W.; Burkhardt, H.G.; Franz, G.; Hutter, E.; Knittel, G.; Neffe, G.; Penzhorn, R.D.

    1978-01-01

    During the test runs of the KRETA plant with the three-component system N 2 -Kr-Xe the concentration range of Kr and Xe in the feed gas could be determined where desublimation in the vicinity of the feed entry into the column takes place. This range decreases with decreasing total gas flow and increasing column pressure. The Kr recycle stream which is being planned for the improved offgas specification system of the WAK (project AZUR) was simulated by increasing the Kr feed concentration. The tendency of xenon to freeze out also decreases by this means. Analysis and control of H 2 during the catalytic reduction of O 2 and NOsub(x) is achieved best using the method of measuring combustion heats. The cell of Leeds and Northrup operates at room temperature and is insensitive towards NOsub(x). CO 2 is partially reduced by H 2 on the Ru-catalyst, but only if there is no O 2 present. Acid resistant molecular sieves (e.g. Norton Zeolen) adsorb Krypton almost twice as well as the type 5A. The same is true with NO. However, NH 3 and NO 2 are adsorbed less strongly on Zeolen as on 5A. (orig.) [de

  2. Optics Program Simplifies Analysis and Design

    Science.gov (United States)

    2007-01-01

    Engineers at Goddard Space Flight Center partnered with software experts at Mide Technology Corporation, of Medford, Massachusetts, through a Small Business Innovation Research (SBIR) contract to design the Disturbance-Optics-Controls-Structures (DOCS) Toolbox, a software suite for performing integrated modeling for multidisciplinary analysis and design. The DOCS Toolbox integrates various discipline models into a coupled process math model that can then predict system performance as a function of subsystem design parameters. The system can be optimized for performance; design parameters can be traded; parameter uncertainties can be propagated through the math model to develop error bounds on system predictions; and the model can be updated, based on component, subsystem, or system level data. The Toolbox also allows the definition of process parameters as explicit functions of the coupled model and includes a number of functions that analyze the coupled system model and provide for redesign. The product is being sold commercially by Nightsky Systems Inc., of Raleigh, North Carolina, a spinoff company that was formed by Mide specifically to market the DOCS Toolbox. Commercial applications include use by any contractors developing large space-based optical systems, including Lockheed Martin Corporation, The Boeing Company, and Northrup Grumman Corporation, as well as companies providing technical audit services, like General Dynamics Corporation

  3. “Deceiving with the Truth”, Arte Nuevo, L. 319

    Directory of Open Access Journals (Sweden)

    Víctor de Lama

    2011-06-01

    Full Text Available The rhetorical device called “deceiving with the truth” (l. 319 et seq. described by Lope de Vega in the Arte Nuevo de hacer comedias has been misinterpreted ever since Morel Fatio confused it with another device mentioned by Lope a little earlier in the text (vv. 300-301, i. e. that of the need for a surprise ending. Later commentators such as H. Rennert and A. Castro, J. de José Prades, J. M. Rozas, F. Pedraza and J. Roso Díaz failed to interpret Lope’s verses correctly, despite the fact that G. T. Northrup (1929-1930 had already offered the keys to an appropriate interpretation. In the meantime, the procedure of “deceiving with the truth” has been unconvincingly identified in works such as La Celestina and dramatic texts of the sixteenth century. In order to confirm its long tradition, the article documents the device’s origin in Terence’s comedies and its use in the Middle Ages and in works such as Don Quixote.

  4. Engineering of the 'PCAST machine'

    International Nuclear Information System (INIS)

    Sinnis, J.; Brooks, A.; Brown, T.

    1996-01-01

    The President's Committee of Advisors on Science and Technology (PCAST) has suggested that a device with a mission of ignition and moderate burn time could address the physics of burning plasmas at a lesser cost than ITER with its more comprehensive physics and technology mission. The Department of Energy commissioned a study to explore this PCAST suggestion. This paper describes the results of the engineering portion of the study of this 'PCAST Machine;' physics is covered in a companion paper authored by G.H. Neilson, et al; and the costs are covered in a companion paper by R.T. Simmons, et al. Both are published in the proceedings of this conference. The study was undertaken by a team under the direction of Bruce Montgomery that included representatives from MIT, PPPL, ORNL, LLNL, GA, Northrup-Grumman, and Stone and Webster. The performance requirements for the PCAST machine are to form and sustain a burning plasma for three helium accumulation times. The philosophy adopted for this design was to achieve the required performance at lower cost by decreasing the major radius to five meters, increasing the toroidal field to 7 tesla, and using stronger shaping. The major device parameters are given. 4 refs., 4 figs., 1 tab

  5. Productivity of clay tailings from phosphate mining: 3. Grain crops

    International Nuclear Information System (INIS)

    Mislevy, P.; Blue, W.G.; Roessler, C.E.; Martin, F.G.

    1991-01-01

    A split-fold field experiment was conducted to study forage and grain yield, forage quality, plant nutrient concentrations, changes in soil nutrients, and 226 Ra contents of four grain crops in various rotations. The crop rotations (1) corn (Zea mays L. Jacques 247)-sunflower (Helianthus annuus L. Cargil 205), (2) sunflower-grain sorghum (Sorghum bicolor L, Moench Northrup King Savanna 5), (3) soybean (Glycine max L. Merr. Williams 80)-grain sorghum, and (4) grain sorghum-soybean (University of Florida V-1) were grown on a dry phosphatic clay with and without a 50-mm surface layer of quartz-sand tailings. Results show that corn and grain sorghum produced highest forage yields and highest grain yields per harvest, respectively. Soybean harvested for forage (Crop 1) contained the highest crude protein and in vitro organic matter digestibility. Concentrations of P, K, Ca, Mg, and Fe in most of the forages were adequate for the diets of beef cattle, while those of Mn, Cu and Zn were low. Mehlich I-extractable soil, Ca, and Mg were considered very high and changed little over the 4-yr production period. Application of 50 mm of sand tailings tended to increase Mehlich I-extractable P, Ca, Mn, Cu, Zn, and Fe. Radium-226 concentration in the forage of all grain crops averaged 8.5 Bq kg -1 , which was about 17 times higher than that in the grain of the same crops. Concentrations of 226 Ra in the forage and grain were 1.1% and 0.09% of the concentration in clay respectively. These data indicate that phosphatic clays can be a valuable resource for the production of corn and sorghum grain that contain low concentrations of 226 Ra

  6. Enabling Technologies for Entrepreneurial Opportunities in 3D printing of SmallSats

    Science.gov (United States)

    Kwas, Andrew; MacDonald, Eric; Muse, Dan; Wicker, Ryan; Kief, Craig; Aarestad, Jim; Zemba, Mike; Marshall, Bill; Tolbert, Carol; Connor, Brett

    2014-01-01

    A consortium of innovative experts in additive manufacturing (AM) comprising Northrup Grumman Technical Services, University of Texas at El Paso (UTEP), Configurable Space Microsystems Innovations & Applications Center (COSMIAC), NASA Glenn Research Center (GRC), and Youngstown State University, have made significant breakthroughs in the goal of creating the first complete 3D printed small satellite. Since AM machines are relatively inexpensive, this should lead to many entrepreneurial opportunities for the small satellite community. Our technology advancements are focused on the challenges of embedding key components within the structure of the article. We have demonstrated, using advanced fused deposition modeling techniques, complex geometric shapes which optimize the spacecraft design. The UTEP Keck Center has developed a method that interrupts the printing process to insert components into specific cavities, resulting in a spacecraft that has minimal internal space allocated for what traditionally were functional purposes. This allows us to increase experiment and instrument capability by provided added volume in a confined small satellite space. Leveraging initial progress made on a NASA contract, the team investigated the potential of new materials that exploit the AM process, producing candidate compositions that exceed the capabilities of traditional materials. These "new materials" being produced and tested include some that have improved radiation shielding, increased permeability, enhanced thermal properties, better conductive properties, and increased structural performance. The team also investigated materials that were previously not possible to be made. Our testing included standard mechanical tests such as vibration, tensile, thermal cycling, and impact resistance as well as radiation and electromagnetic tests. The initial results of these products and their performance will be presented and compared with standard properties. The new materials with

  7. The LIFE Laser Design in Context: A Comparison to the State-of-the-Art

    International Nuclear Information System (INIS)

    Deri, R.J.; Bayramian, A.J.; Erlandson, A.C.

    2011-01-01

    The current point design for the LIFE laser leverages decades of solid-state laser development in order to achieve the performance and attributes required for inertial fusion energy. This document provides a brief comparison of the LIFE laser point design to other state-of-the-art solid-state lasers. Table I compares the attributes of the current LIFE laser point design to other systems. the state-of-the-art for single-shot performance at fusion-relevant beamline energies is exemplified by performance observed on the National Ignition Facility. The state-of-the-art for high average power is exemplified by the Northrup Grumman JHPSSL laser. Several items in Table I deal with the laser efficiency; a more detailed discussion of efficiency can be found in reference 5. The electrical-to-optical efficiency of the LIFE design exceeds that of reference 4 due to the availability of higher efficiency laser diode pumps (70% vs. ∼50% used in reference 4). LIFE diode pumps are discussed in greater detail in reference 6. The 'beam steering' state of the art is represented by the deflection device that will be used in the LIFE laser, not a laser system. Inspection of Table I shows that most LIFE laser attributes have already been experimentally demonstrated. The two cases where the LIFE design is somewhat better than prior experimental work do not involve the development of new concepts: beamline power is increased simply by increasing aperture (as demonstrated by the power/aperture comparison in Table I), and efficiency increases are achieved by employing state-of-the-art diode pumps. In conclusion, the attributes anticipated for the LIFE laser are consistent with the demonstrated performance of existing solid-state lasers.

  8. Estimation of soil texture and plant available water by correlation with the laser light-scattering method

    Energy Technology Data Exchange (ETDEWEB)

    Haverland, R. L.; Post, D. F.; Cooper, L. R.; Shirley, E. D.

    1985-07-01

    Particle -size distribution and plant available water are basic input to studies of range, forest and cultivated land. Since the conventional laboratory procedures for determining these parameters are time consuming, an improved method for making these measurements is desirable. Weiss and Frock (1976) reported results from an instrument employing the principle of laser light scattering to measure particle -size distribution. The instrument was reported to be of high precision, and yielded reproducible results. The laser light- scattering instrument used in this study is the Microtrac Particle -size Analyzer Model 7991- 0, manufactured by Leeds and Northrup. The particle -size analysis range of this model is from 1.9 to 176 μm, which does not correspond to the entire fine earth fraction (< 2 mm) usually characterized by soil scientists. It is, therefore, desirable to develop predictive equations to estimate the soil texture of the fine earth fraction. We believe data from this instrument could be used to predict other soil properties. This paper reports on using Microtrac data to estimate the plant available water holding capacity and soil texture of Arizona soils. Two hundred and forty-seven Arizona soils were used in this study. Most of these soils (approximately 230 soils) are thermic or hyperthermic and arid or semiarid soils of dominantly mixed mineralogy, as described on the Arizona General Soils Map (Jay et al., 1975). An array of soil horizons are included, with approximately one half of the samples coming from the A or Ap surface horizons. The other half of the samples are from the subsurface B or C horizons.

  9. CCT-K2.1: NRC/VNIIFTRI bilateral comparison of capsule-type standard platinum resistance thermometers from 13.8 K to 273.16 K

    Energy Technology Data Exchange (ETDEWEB)

    Hill, K.D.; Steele, A.G. [National Research Council of Canada, Institute for National Measurement Standards, Ottawa, ON (Canada); Dedikov, Y.A.; Shkraba, V.T. [Institute for Physical-Technical and Radiotechnical Measurements (VNIIFTRI), Moscow (Russian Federation)

    2005-04-01

    The Consultative Committee for Thermometry Key Comparison 2 (CCT-K2) results were published two years ago (2002 Metrologia 39 551-71). NRC served as the pilot laboratory for CCT-K2 and remains able to provide a scale and measurement system suitable for performing bilateral comparisons linked to the original key comparison results. In March 2003, measurements of two VNIIFTRI 100 {omega} capsule-style platinum resistance thermometers (CSPRTs), S/N 356 and 476, were undertaken to relate their local calibration to the results from the CCT-K2 exercise. The NRC Leeds and Northrup (L and N) CSPRT S/N 1872174 provides the link to the CCT-K2 results. The three CSPRTs were compared at the eight defining cryogenic temperatures of the International Temperature Scale of 1990 (ITS-90) in the range from 13.8033 K to 273.16 K. The reader is referred to the full text of the CCT-K2 report for a detailed explanation of the methodology employed for the comparison. Only the details unique to the measurements reported here will be addressed in this article. The NRC/VNIIFTRI bilateral comparison of capsule-style platinum resistance thermometers over the range 13.8 K to 273.16 K has revealed calibrations at VNIIFTRI to be in agreement with the KCRV of CCT-K2 within the expanded uncertainty for all temperatures of the comparison with the exception of the triple point of hydrogen at 13.8033 K. One of the two CSPRTs supplied by VNIIFTRI was found to be discrepant as revealed by differences at the triple point of water and at the lowest temperatures of the comparison, and was therefore excluded from further analysis. The linkage to the CCT-K2 data supports the evaluation of the VNIIFTRI CMCs in Appendix C of the KCDB. (authors)

  10. Gallium adsorption on (0001) GaN surfaces

    International Nuclear Information System (INIS)

    Adelmann, Christoph; Brault, Julien; Mula, Guido; Daudin, Bruno; Lymperakis, Liverios; Neugebauer, Joerg

    2003-01-01

    We study the adsorption behavior of Ga on (0001) GaN surfaces combining experimental specular reflection high-energy electron diffraction with theoretical investigations in the framework of a kinetic model for adsorption and ab initio calculations of energy parameters. Based on the experimental results we find that for substrate temperatures and Ga fluxes typically used in molecular-beam epitaxy of GaN, finite equilibrium Ga surface coverages can be obtained. The measurement of a Ga/GaN adsorption isotherm allows the quantification of the equilibrium Ga surface coverage as a function of the impinging Ga flux. In particular, we show that a large range of Ga fluxes exists, where 2.5±0.2 monolayers (in terms of the GaN surface site density) of Ga are adsorbed on the GaN surface. We further demonstrate that the structure of this adsorbed Ga film is in good agreement with the laterally contracted Ga bilayer model predicted to be most stable for strongly Ga-rich surfaces [Northrup et al., Phys. Rev. B 61, 9932 (2000)]. For lower Ga fluxes, a discontinuous transition to Ga monolayer equilibrium coverage is found, followed by a continuous decrease towards zero coverage; for higher Ga fluxes, Ga droplet formation is found, similar to what has been observed during Ga-rich GaN growth. The boundary fluxes limiting the region of 2.5 monolayers equilibrium Ga adsorption have been measured as a function of the GaN substrate temperature giving rise to a Ga/GaN adsorption phase diagram. The temperature dependence is discussed within an ab initio based growth model for adsorption taking into account the nucleation of Ga clusters. This model consistently explains recent contradictory results of the activation energy describing the critical Ga flux for the onset of Ga droplet formation during Ga-rich GaN growth [Heying et al., J. Appl. Phys. 88, 1855 (2000); Adelmann et al., J. Appl. Phys. 91, 9638 (2002).

  11. KEY COMPARISON: CCT-K2.1: NRC/VNIIFTRI bilateral comparison of capsule-type standard platinum resistance thermometers from 13.8 K to 273.16 K

    Science.gov (United States)

    Hill, K. D.; Steele, A. G.; Dedikov, Y. A.; Shkraba, V. T.

    2005-01-01

    The Consultative Committee for Thermometry Key Comparison 2 (CCT-K2) results were published two years ago (2002 Metrologia 39 551-71). NRC served as the pilot laboratory for CCT-K2 and remains able to provide a scale and measurement system suitable for performing bilateral comparisons linked to the original key comparison results. In March 2003, measurements of two VNIIFTRI 100 Ω capsule-style platinum resistance thermometers (CSPRTs), S/N 356 and 476, were undertaken to relate their local calibration to the results from the CCT-K2 exercise. The NRC Leeds and Northrup (L&N) CSPRT S/N 1872174 provides the link to the CCT-K2 results. The three CSPRTs were compared at the eight defining cryogenic temperatures of the International Temperature Scale of 1990 (ITS-90) in the range from 13.8033 K to 273.16 K. The reader is referred to the full text of the CCT-K2 report for a detailed explanation of the methodology employed for the comparison. Only the details unique to the measurements reported here will be addressed in this article. The NRC/VNIIFTRI bilateral comparison of capsule-style platinum resistance thermometers over the range 13.8 K to 273.16 K has revealed calibrations at VNIIFTRI to be in agreement with the KCRV of CCT-K2 within the expanded uncertainty for all temperatures of the comparison with the exception of the triple point of hydrogen at 13.8033 K. One of the two CSPRTs supplied by VNIIFTRI was found to be discrepant as revealed by differences at the triple point of water and at the lowest temperatures of the comparison, and was therefore excluded from further analysis. The linkage to the CCT-K2 data supports the evaluation of the VNIIFTRI CMCs in Appendix C of the KCDB. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCT, according to the provisions

  12. 9-17 Soil Properties under Selected Homestead Grown Indigenous ...

    African Journals Online (AJOL)

    1Holetta Agricultural Research Center, P O Box 2003, Addis Ababa, Ethiopia. 2Institute of ... 3Institute of Applied Geology, UNI BOKU, Peter-Jordan Strasse 70, A-1190, Vienna, Austria ... shade and soil fertility improvement) (Berhane et al.,.

  13. Efficient expression of green fluorescent protein (GFP) mediated by a chimeric promoter in Chlamydomonas reinhardtii

    Science.gov (United States)

    Wu, Jinxia; Hu, Zhangli; Wang, Chaogang; Li, Shuangfei; Lei, Anping

    2008-08-01

    To improve the expression efficiency of exogenous genes in Chlamydomonas reinhardtii, a high efficient expression vector was constructed. Green fluorescent protein (GFP) was expressed in C. reinhardtii under the control of promoters: RBCS2 and HSP70A-RBCS2. Efficiency of transformation and expression were compared between two transgenic algae: RBCS2 mediated strain Tran-I and HSP70A-RBCS2 mediated strain Tran-II. Results show that HSP70A-RBCS2 could improve greatly the transformation efficiency by approximately eightfold of RBCS2, and the expression efficiency of GFP in Tran-II was at least double of that in Tran-I. In addition, a threefold increase of GFP in Tran-II was induced by heat shock at 40°C. All of the results demonstrated that HSP70A-RBCS2 was more efficient than RBCS2 in expressing exogenous gene in C. reinhardtii.

  14. Bayou Corne sinkhole : control measurements of State Highway 70 in Assumption Parish, Louisiana, tech summary.

    Science.gov (United States)

    2014-01-01

    The sinkhole located in Assumption Parish, Louisiana, threatens the stability of Highway 70, a state maintained route. In order to : mitigate the potential damaging e ects of the sinkhole on this infrastructure, the Louisiana Department of Transpo...

  15. Bayou Corne Sinkhole: Control Measurements of State Highway 70 in Assumption Parish, Louisiana : Research Project Capsule

    Science.gov (United States)

    2012-09-01

    The sinkhole located in northern Assumption Parish, Louisiana, threatens : the stability of Highway 70, a state-maintained route. In order to monitor : and mitigate potential damage eff ects on this infrastructure, the Louisiana : Department of Trans...

  16. CORS 911 : continuously operating reference stations for the Bayou Corne sinkhole.

    Science.gov (United States)

    2013-06-01

    The sinkhole located near the Napoleonville Salt Dome in Assumption Parish, Louisiana : threatens the stability of LA 70 a state maintained route. In order to mitigate the : possible damaging eff ects of the sinkhole to the route and address publ...

  17. Notas clínicas: Un quiste mucoide del ovario derecho de treinta y cuatro libras de peso, extraído con feliz éxito a una anciana de setenta años

    Directory of Open Access Journals (Sweden)

    Arturo Durán D.

    1933-12-01

    servicio de mujeres, salón de caridad, a cargo del doctor Alejandro Bernal Jiménez, del Hospital San José del Líbano, Departamento del Tolima, la enferma L. S., de 70 años de edad natural de Chiquinquirá, hija de Manuel Sánchez y Joaquina Cortés.

  18. Synergistic anti-tumor effects of nitroreductase mutants and p53

    Directory of Open Access Journals (Sweden)

    Mahboobeh Razmkhah

    2014-01-01

    Conclusion: Combination of T41L/F70A NTR with p53 may have more advantages for treatment of different types of cancers compared to the other NTRs and p53 alone. The present study results may open new windows for getting desired outcome in gene therapy of different types of cancer.

  19. 48 CFR 1852.215-78 - Make or buy program requirements.

    Science.gov (United States)

    2010-10-01

    ... and size status. (g) Any recommendations to defer make-or-buy decisions when categorization of some... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Make or buy program... and Clauses 1852.215-78 Make or buy program requirements. As prescribed in 1815.408-70(a), insert the...

  20. 48 CFR 252.229-7001 - Tax relief.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Tax relief. 252.229-7001... Clauses 252.229-7001 Tax relief. As prescribed in 229.402-70(a), use the following clause: Tax Relief (JUN 1997) (a) Prices set forth in this contract are exclusive of all taxes and duties from which the United...

  1. Nota editorial: el profesor Henri Vaquez

    Directory of Open Access Journals (Sweden)

    José Alberto Camacho

    1936-05-01

    Full Text Available El profesor Vaquez ha muerto a la edad de 70 años en su residenciade la rue Debussi en París, rodeado de sus discípulos y lamentado por todos aquellos que nutrieron sus mentes con la ciencia y la filosofía vertidas a raudales de su espíritu generoso.

  2. 48 CFR 652.239-70 - Information Technology Security Plan and Accreditation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Information Technology... Clauses 652.239-70 Information Technology Security Plan and Accreditation. As prescribed in 639.107-70(a), insert the following provision: Information Technology Security Plan and Accreditation (SEP 2007) All...

  3. Sibelius. Karelia Suite, Op. 11 / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1996-01-01

    Uuest heliplaadist "Sibelius. Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi" DG 447 760-2GH (72 minutes: DDD)

  4. Pulse generation and compression using an asymmetrical porous ...

    Indian Academy of Sciences (India)

    2016-11-03

    Nov 3, 2016 ... DOI 10.1007/s12043-016-1301-z. Pulse generation ... Silicon nanophotonics; porous silicon waveguide; pulse generation and compression. PACS Nos 42.70. ..... a switching single- and double-pulse generation tech- nique is ...

  5. Impacto del tratamiento anticalcificación en la durabilidad de la bioprótesis Mitroflow y factores de riesgo para el deterioro valvular estructural

    Directory of Open Access Journals (Sweden)

    Víctor X. Mosquera

    2017-03-01

    Conclusiones: El comportamiento hemodinámico postoperatorio precoz, el tamaño valvular de 19 mm y una edad del paciente < 70 años son factores de riesgo para el DVE. El tratamiento anticalcificación del modelo DL reduce la incidencia de DVE y extiende la vida de la bioprótesis.

  6. 48 CFR 1852.210-70 - Brand name or equal.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Brand name or equal. 1852... 1852.210-70 Brand name or equal. As prescribed in 1810.011-70(a), insert the following provision: Brand Name or Equal (DEC 1988) (a) As used in this provision, “brand name” means identification of products...

  7. An Average Daily Number of Steps Negatively Correlates with an Average Glycemic Value in Type I Diabetic Patients: Comparison between CGM and Pedometer Records

    Czech Academy of Sciences Publication Activity Database

    Brož, J.; Holubová, A.; Mužík, J.; Oulická, M.; Mužný, M.; Poláček, M.; Fiala, D.; Arsand, E.; Brabec, Marek; Kvapil, M.

    2016-01-01

    Roč. 18, Suppl. 1 (2016), A70-A70 ISSN 1520-9156. [ATTD 2016. International Conference on Advanced Technologies & Treatments for Diabetes /9./. 03.02.2016-06.02.2016, Milan] Institutional support: RVO:67985807 Subject RIV: BB - Applied Statistics, Operational Research

  8. Assessment of correlation between knee notch width index and the three-dimensional notch volume

    NARCIS (Netherlands)

    van Eck, C.F.; Martins, C.A.Q.; Lorenz, S.G.F.; Fu, F.H.; Smolinski, P.

    2010-01-01

    This study was done to determine whether there is a correlation between the notch volume and the notch width index (NWI) as measured on the three most frequently used radiographic views: the Holmblad 45A degrees, Holmblad 70A degrees, and Rosenberg view. The notch volume of 20 cadaveric knees was

  9. 48 CFR 352.237-70 - Pro-Children Act.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Pro-Children Act. 352.237...-Children Act. As prescribed in 337.103-70(a), the Contracting Officer shall insert the following clause: Pro-Children Act (January 2006) (a) Public Law 103-227, Title X, Part C, also known as the Pro...

  10. 48 CFR 252.216-7000 - Economic price adjustment-basic steel, aluminum, brass, bronze, or copper mill products.

    Science.gov (United States)

    2010-10-01

    ...-basic steel, aluminum, brass, bronze, or copper mill products. 252.216-7000 Section 252.216-7000 Federal... adjustment—basic steel, aluminum, brass, bronze, or copper mill products. As prescribed in 216.203-4-70(a... Mill Products (JUL 1997) (a) Definitions. As used in this clause— Established price means a price which...

  11. 48 CFR 2052.211-70 - Preparation of technical reports.

    Science.gov (United States)

    2010-10-01

    ....211-70 Preparation of technical reports. As prescribed at 2011.104-70(a), the contracting officer... Reports (JAN 1993) All technical reports required by Section C and all Technical Progress Reports required... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Preparation of technical...

  12. 78 FR 76074 - Department of State Acquisition Regulation

    Science.gov (United States)

    2013-12-16

    ... DOSAR Sec. Sec. 652.245-70(a)(3) and 652.245-71, on the theory that Part 45 governs the management and... expectancy to exceed two years. (b) The contracting officer shall insert the clause at 652.245-71, Special... property when put into use; and is of a durable nature with an estimated useful life expectancy to exceed...

  13. Role of teh Rad52 Amino-terminal DNA Binding Activity in DNA Strand Capture in Homologous Recombination

    DEFF Research Database (Denmark)

    Shi, Idina; Hallwyl, Swee Chuang Lim; Seong, Changhyun

    2009-01-01

    Saccharomyces cerevisiae Rad52 protein promotes homologous recombination by nucleating the Rad51 recombinase onto replication protein A-coated single-stranded DNA strands and also by directly annealing such strands. We show that the purified rad52-R70A mutant protein, with a compromised amino-ter...

  14. The anatomy of a radio source hot spot : Very large baseline array imaging of 3C 205

    NARCIS (Netherlands)

    Lonsdale, CJ; Barthel, PD

    Total intensity and linear polarization Very Long Baseline Array (VLBA) images of the high-redshift quasar 3C 205 at a wavelength of 18 cm reveal a complex curved hot-spot structure with polarization percentages frequently as high as 70%. A one-sided jet is detected emerging from the central

  15. Basic metabolic panel

    Science.gov (United States)

    ... CO2 (carbon dioxide) : 20 to 29 mmol/L Creatinine : 0.8 to 1.2 mg/dL (70. ... a sample of blood: BUN (blood urea nitrogen) Creatinine CO2 (carbon dioxide) Glucose Serum chloride Serum potassium ...

  16. 77 FR 68058 - Airworthiness Directives; Sikorsky Aircraft Corporation Helicopters

    Science.gov (United States)

    2012-11-15

    ... Airworthiness Directives; Sikorsky Aircraft Corporation Helicopters AGENCY: Federal Aviation Administration (FAA... airworthiness directive (AD) for Sikorsky Aircraft Corporation (Sikorsky) Model S-70, S-70A, S-70C, S-70C(M... after receipt. For service information identified in this AD, contact Sikorsky Aircraft Corporation...

  17. 48 CFR 1252.228-71 - Fair market value of aircraft.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Fair market value of....228-71 Fair market value of aircraft. As prescribed in (TAR) 48 CFR 1228.306-70(a) and (c), insert the following clause: Fair Market Value of Aircraft (OCT 1994) For purposes of the clause entitled “Loss of or...

  18. 48 CFR 1852.219-73 - Small business subcontracting plan.

    Science.gov (United States)

    2010-10-01

    ... Provisions and Clauses 1852.219-73 Small business subcontracting plan. As prescribed in 1819.708-70(a), insert the following provision: Small Business Subcontracting Plan (MAY 1999) (a) This provision is not... contain FAR clause 52.219-9, “Small Business Subcontracting Plan.” The apparent low bidder must submit the...

  19. EXO70C2 is a key regulatory factor for optimal tip growth of pollen

    KAUST Repository

    Synek, Lukas; Vukasinovic, Nemanja; Kulich, Ivan; Hala, Michal; Aldorfova, Klara; Fendrych, Matyas; Zarsky, Viktor

    2017-01-01

    paralogs. Out of 23 Arabidopsis EXO70 isoforms, we analyzed seven isoforms expressed in pollen. Genetic and microscopic analyses of single mutants in EXO70A2, C1, C2, F1, H3, H5, and H6 genes revealed that only a loss-of-function EXO70C2 allele resulted

  20. Oxidative burst of human neutrophils is suppressed by N-feruloylserotonin isolated from seeds of Leuzea carthamoides (Wild) DC

    Czech Academy of Sciences Publication Activity Database

    Nosáľ, R.; Perečko, T.; Jančinová, V.; Drábiková, K.; Harmatha, Juraj; Sviteková, K.

    2010-01-01

    Roč. 3, č. 3 (2010), A70-A71 ISSN 1337-6853. [Toxcon 2010, Borderless Toxicology. 15th Interdisciplinary Toxicological Conference & Advanced Toxicological Course. 06.09.-10.09.2010, Stará Lesná - Hotel Academia] R&D Projects: GA ČR(CZ) GA203/07/1227 Institutional research plan: CEZ:AV0Z40550506 Keywords : N-feruloylserotonin * human neutrophils * Leuzea carthamoides Subject RIV: CC - Organic Chemistry

  1. Offense-Defense Balance in Cyberspace: A Proposed Model

    Science.gov (United States)

    2012-12-01

    enable faster multitasking , the more computations per second can be accomplished. Increased processing speed will allow an attacker to send attacks...depend on what spam or DDoS needs to be accomplished with prices ranging from $30-$70 a day for DDoS to $10 for 1 million spam emails . 21 For...In addition to DDoS attacks on webservers, there were web defacements (using various tools such as SQL injections) and email flooding. The attacks

  2. Nuclear instrumentation for research reactors

    International Nuclear Information System (INIS)

    Hofer, Carlos G.; Pita, Antonio; Verrastro, Claudio A.; Maino, Eduardo J.

    1997-01-01

    The nuclear instrumentation for research reactors in Argentina was developed in 70'. A gradual modernization of all the nuclear instrumentation is planned. It includes start-up and power range instrumentation, as well as field monitors, clamp, scram and rod movement control logic. The new instrumentation is linked to a computer network, based on real time operating system for data acquisition, display and logging. This paper describes the modules and whole system aspects. (author). 2 refs

  3. Nuclear instrumentation for research reactors; Instrumentacion nuclear para reactores nucleares de investigacion

    Energy Technology Data Exchange (ETDEWEB)

    Hofer, Carlos G.; Pita, Antonio; Verrastro, Claudio A.; Maino, Eduardo J. [Comision Nacional de Energia Atomica, Buenos Aires (Argentina). Unidad de Actividades de Reactores y Centrales Nucleares. Sector Instrumentacion y Control

    1997-10-01

    The nuclear instrumentation for research reactors in Argentina was developed in 70`. A gradual modernization of all the nuclear instrumentation is planned. It includes start-up and power range instrumentation, as well as field monitors, clamp, scram and rod movement control logic. The new instrumentation is linked to a computer network, based on real time operating system for data acquisition, display and logging. This paper describes the modules and whole system aspects. (author). 2 refs.

  4. Sistema de transporte urbano masivo de pasajeros de Bogotá Transmilenio

    Directory of Open Access Journals (Sweden)

    Antonio Martínez Olmedo

    2003-01-01

    Full Text Available "Los bogotanos que llegaron a los 70 años de edad, perdieron, en promedio, 10 años de su vida sentados en un bus. Allí vieron recortada su recreación, dejaron de compartir ese tiempo con su familia, e indefectiblemente, fueron ahogados por el estrés."

  5. Obrana, akvizice či nesoutěž? Jak se měnila podoba a intenzita soutěže mezi českými stranami v letech 2006–2014?

    Czech Academy of Sciences Publication Activity Database

    Linek, Lukáš; Chytilek, R.; Eibl, O.

    2016-01-01

    Roč. 52, č. 5 (2016), s. 647-677 ISSN 0038-0288 R&D Projects: GA ČR GA13-29032S Institutional support: RVO:68378025 Keywords : party competition * policy space * elections Subject RIV: AD - Politology ; Political Sciences Impact factor: 0.143, year: 2016 http://sreview.soc.cas.cz/uploads/70a2d9726f9752076806f3ea629d82f0978426ff_16-5-04Linek22.indd.pdf

  6. The transport and distribution of 3H-ABA affected by al sress on soybean seedig

    International Nuclear Information System (INIS)

    Chen Guang; Sun Yang; Pang Jinduo

    2010-01-01

    A hydroponic experiment combining radioisotope techniques was carried out to understand the effect of Al stress on the transport and the distribution of 3 H-ABA by using Jilin70, a soybean variety of Al resistance. The transport and distribution of ABA affected by Al stress on soybean seedling were studied with radioisotope technique. The results showed that ABA could be transported up or down in soybean seedling. The stress of Al accelerated the transport of ABA and enhanced the distribution of ABA in the roots by Al stress. The paper present the foundation for the mechanisms of ABA under Al stress in plant. (authors)

  7. Literatura y violencia en la narrativa latinoamericana reciente

    OpenAIRE

    Basile, Teresa

    2015-01-01

    Los trabajos reunidos en Literatura y violencia en la narrativa latinoamericana reciente interrogan los modos de narrar las experiencias extremas de la historia latinoamericana de las últimas décadas. Configuran un variado mapa de la violencia de las últimas décadas, que comienza con las dictaduras del Cono Sur y arriba a los setecientos femicidios de Ciudad Juárez; un recorrido que va de sur a norte, de los 70 a los 90, de la violencia dictatorial a la violencia neoliberal y a la guerra de l...

  8. Componentes de tecnologías para la pesca (instrumentos Traful en ambientes lacustres y boscosos andinos norpatagónicos, Argentina

    Directory of Open Access Journals (Sweden)

    Alberto Enrique Pérez

    2017-12-01

    Full Text Available La funcionalidad de los Instrumentos Traful es incierta luego de 70 años de su descripción. A partir de su diseño morfológico, el contexto ambiental y arqueológico asociado, postulamos que son parte de un “instrumento compuesto” especializado en la pesca. Si bien presentan características singulares en el contexto lacustre y rivereño del interior de la Patagonia noroccidental argentina, se asemejan en cuestiones básicas a los pesos de líneas marinos de gran distribución magallánica.

  9. The Army and the Endangered Species Act: Who’s Endangering Whom?

    Science.gov (United States)

    1993-04-01

    beatles , and other insects it discovers within the bark or sapwood of a tree. 0 50 The RCWs are specialists among specialists, in that they are * the ...trees as well. Their diet consists mainly of ants and beatles discovered within the bark and sapwood of pine trees. Older trees provide better foraging...THIS SHEET AND RETRrN TO mTlC-FDAC DTIC n 70A DOCLUMMT PROCESSING s]rL=Tssu~y•m~~ LOAN DOCUMENT THE ARMY AND THE ENDANGERED SPECIES ACT: WHO’ S

  10. Tratamiento fisioterapico en pacientes con lesión en territorio de la arteria cerebral media.

    OpenAIRE

    Bays Moneo, Ana Beatriz

    2014-01-01

    Paciente de 70 años que padece una hemiparesia derecha con afasia de Broca de casi dos años de evolución como consecuencia de una oclusión de arteria carótida interna que provocó un infarto en el territorio de la arteria cerebral media. Para su tratamiento se ha utilizado el concepto Bobath. Durante el mismo, tuvo una frecuencia de tres sesiones por semana de 45 minutos durante cuatro meses. El paciente mostraba como problema principal, un pie con gran tendencia al equ...

  11. The four hexamerin genes in the honey bee: structure, molecular evolution and function deduced from expression patterns in queens, workers and drones.

    Science.gov (United States)

    Martins, Juliana R; Nunes, Francis M F; Cristino, Alexandre S; Simões, Zilá L P; Bitondi, Márcia M G

    2010-03-26

    Hexamerins are hemocyanin-derived proteins that have lost the ability to bind copper ions and transport oxygen; instead, they became storage proteins. The current study aimed to broaden our knowledge on the hexamerin genes found in the honey bee genome by exploring their structural characteristics, expression profiles, evolution, and functions in the life cycle of workers, drones and queens. The hexamerin genes of the honey bee (hex 70a, hex 70b, hex 70c and hex 110) diverge considerably in structure, so that the overall amino acid identity shared among their deduced protein subunits varies from 30 to 42%. Bioinformatics search for motifs in the respective upstream control regions (UCRs) revealed six overrepresented motifs including a potential binding site for Ultraspiracle (Usp), a target of juvenile hormone (JH). The expression of these genes was induced by topical application of JH on worker larvae. The four genes are highly transcribed by the larval fat body, although with significant differences in transcript levels, but only hex 110 and hex 70a are re-induced in the adult fat body in a caste- and sex-specific fashion, workers showing the highest expression. Transcripts for hex 110, hex 70a and hex70b were detected in developing ovaries and testes, and hex 110 was highly transcribed in the ovaries of egg-laying queens. A phylogenetic analysis revealed that HEX 110 is located at the most basal position among the holometabola hexamerins, and like HEX 70a and HEX 70c, it shares potential orthology relationship with hexamerins from other hymenopteran species. Striking differences were found in the structure and developmental expression of the four hexamerin genes in the honey bee. The presence of a potential binding site for Usp in the respective 5' UCRs, and the results of experiments on JH level manipulation in vivo support the hypothesis of regulation by JH. Transcript levels and patterns in the fat body and gonads suggest that, in addition to their primary

  12. Diversity and Evolution of papillomaviruses

    OpenAIRE

    Mengual Chuliá, Beatriz

    2017-01-01

    1.1. Introducción Con el fin de averiguar las causas de las devastadoras epidemias de finales del siglo XIX, se llevaron a cabo diferentes estudios que dieron como resultado la identificación de unos nuevos agentes infecciosos, para los que se acuñó el nombre de “virus”. Desde entonces el descubrimiento de nuevos virus ha sido incesante, lo que llevó, en los años 70, a la creación de un organismo encargado de desarrollar, refinar y mantener la clasificación taxonómica de los virus, el Com...

  13. The Detection and Discrimination of Small Munitions using Giant Magnetoresistive (OMR) Sensors

    Science.gov (United States)

    2010-09-01

    Suffield, Canada. McGlone, D.T., 1998, Magnetometer Comparison Smoke Creek Instruments’ GMR SCIMAG- 01 & Bartington Fluxgate MAG-03MC70, A...a magnetometer and frequency domain or time domain electromagnetic induction sensor. Both the Honeywell and NVE GlvlR sensors studied have si.m ilar...field sensor. In p0ssive mode, the GMR sensor, which has a resolution of Jess than l 0 nT, perfom1ed similarly to a cesium vapor magnetometer . When

  14. Evolución en el tiempo de las relaciones Masa-Luminosidad y Corrección Bolométrica y Temperatura Efectiva contra Índice de Color

    Science.gov (United States)

    Miloni, L. A.; Camperi, J. A.

    Analizamos la evolución que en los últimos 70 años han tenido las relaciones M-L, BC vs CI y Teff vs CI. Se discuten las causas de esa evolución, se trata de incorporar los valores más modernos disponibles discutiendo su calidad y se deducen las relaciones que actualmente deberían ser las más confiables. Destacamos los puntos en los que estas relaciones continúan estando pobremente definidas y sería deseable mejorar en el futuro próximo.

  15. Programas de reabilitação auditiva para idosos: uma proposta alternativa de avaliação de eficácia

    OpenAIRE

    Lombardi,Christiane Mara; Freire,Regina Maria

    2011-01-01

    OBJETIVO: analisar a eficácia de um programa de reabilitação auditiva para idosos. MÉTODOS: participaram deste estudo 30 sujeitos com perda auditiva de grau moderado a severo, na faixa etária de 70 a 92 anos, usuários de auxiliar auditivo com adaptação uni e bilateral e participantes do Grupo de Apoio ao Usuário de Auxiliar Auditivo - GAUAA - desenvolvido durante quatro encontros mensais. Foi aplicado o questionário QI-AASI (Questionário Internacional-Aparelho De Amplificação Sonora Individua...

  16. Avaliação multidimensional dos determinantes do envelhecimento ativo em idosos de um município de Santa Catarina

    OpenAIRE

    Fernanda Regina Vicente; Silvia Maria Azevedo dos Santos

    2013-01-01

    Este estúdio tuvo como objetivo evaluar los determinantes del envejecimiento activo en ancianos de 60 a 70 años residentes en Rodeio-SC. Estudio cuantitativo, exploratorio-descriptivo, cuya recopilación de datos ocurrió entre Abril y Agosto del 2011. Entrevistados 264 ancianos en sus hogares mediante utilización del instrumento para evaluación multidimensional del envejecimiento activo, después de la validación de contenido, realizada por peritos. Los datos fueron organizados en una hoja de c...

  17. Comportamiento clínico epidemiológico del grupo de adultos mayores del Centro de Salud Tosagua, año 2016

    Directory of Open Access Journals (Sweden)

    Jorge Javier Bergues

    2018-03-01

    Conclusiones: El grupo estudiado estuvo integrado mayormente por adultos mayores de menos de 70 años y predomino el sexo femenino. La hipertensión como entidad que principalmente presentaron los ancianos. Durante el periodo estudiado la mayoría de los hipertensos se mantuvieron compensados; sin embargo, la mayoría de los pacientes con diabetes mellitus estuvieron descompensados. El losartán es el antihipertensivo más utilizado. La metformina es el hipoglucemiante de mayor uso.

  18. Artrosis en la articulación temporo-mandibular

    OpenAIRE

    Muñoz, Pablo Nicolás

    2017-01-01

    Se presenta un caso clínico de una paciente de 70 años que acusa dolor orofacialsimétrico y dolor local a nivel de la articulación temporo-mandibular (ATM) derecha. La exploración clínica muestra disminución del rango de movimiento articular, crepitación a la auscultación, y puntos gatillos miofascialesa nivel de la musculatura masticatoria. El estudio radiológico confirma artrosis en la ATM y se termina concluyendo que la sintomatología es provocada, principalmente, por el síndrome de dolor ...

  19. Preparation of mandatory documentation before the start up of the RA-0 'zero power' nuclear reactor at Cordoba National University

    International Nuclear Information System (INIS)

    Martin, H.R.; Keil, W.M.; Pezzi, N.

    1991-01-01

    Before the start up of the RA-0 'zero power' nuclear reactor installed at Cordoba National University, it was necessary to send to the Regulatory Authority the mandatory documentation which is required in the licensing process. With the previous papers existing for the operation in the first years of the '70, a work program for the future operational training personnel was elaborated. Based on the Authority's applicable rules and the recommendations and with particular criteria originated in the working university conditions, the SAFETY report of RA-0 nuclear reactor was prepared. This paper describes the principal contents, items and documents involved in the safety report. (Author) [es

  20. Experimental Investigation on Friction and Wear Properties of Different Steel Materials

    OpenAIRE

    M.A. Chowdhury; D.M. Nuruzzaman

    2013-01-01

    Friction coefficient and wear rate of different steel materials are investigated and compared in this study. In order to do so, a pin on disc apparatus is designed and fabricated. Experiments are carried out when different types of disc materials such as stainless steel 314 (SS 314), stainless steel 202 (SS 202) and mild steel slide against stainless steel 314 (SS 314) pin. Experiments are conducted at normal load 10, 15 and 20 N, sliding velocity 1, 1.5 and 2 m/s and relative humidity 70%. A...

  1. Efectividad de distintas terapias físicas en el tratamiento conservador de la fascitis plantar. Revisión sistemática

    OpenAIRE

    Ana María Díaz López; Patricia Guzmán Carrasco

    2014-01-01

    Fundamentos: La fascitis plantar es la afección más frecuente de dolor no traumático en el tobillo-pie. Se presenta más en mujeres entre los 40-70 años con comienzo progresivo y difuso en planta del pie o tobillo que poco a poco se agudiza impidiendo la marcha. El objetivo de este trabajo es determinar si las distintas terapias físicas utilizadas en el tratamiento conservador de la fascitis plantar de al menos un mes de evolución son efectivas individualmente y/o combinadas entre sí. Métodos:...

  2. IMPACT OF THE STRATEGIES IN THE PERFORMANCE OF THE SIDERURGICAL COMPANIES

    OpenAIRE

    FERNANDO HOR-MEYLL ALVARES

    2001-01-01

    Desde o final da década de 70, a indústria siderúrgica brasileira vinha sofrendo com a presença maciça do governo no setor, pois se ressentia da falta dos investimentos necessários para a renovação e ampliação do parque siderúrgico. Esta falta de investimentos provocava, também, a perda de competitividade das empresas siderúrgicas brasileiras frente às suas concorrentes no mercado internacional. A saída do Estado do setor siderúrgico, a partir das privatizações...

  3. Intermolecular interaction potentials of the methane dimer from the local density approximation

    International Nuclear Information System (INIS)

    Chen Xiangrong; Bai Yulin; Zhu Jun; Yang Xiangdong

    2004-01-01

    The intermolecular interaction potentials of methane (CH 4 ) dimer are calculated within the density functional theory in the local density approximation (LDA). It is found that the calculated potentials have minima when the intermolecular distance of CH 4 dimer is about 7.0 a.u., which is in good agreement with the experiment. The depth of the potential is 0.017 eV. The results obtained by our LDA calculations seem to agree well with those obtained by MP2, MP3, and CCSD from the Moeller-Plesset and coupled cluster methods by Tsuzuki et al. and with the experimental data

  4. Modeling of Inelastic Collisions in a Multifluid Plasma: Excitation and Deexcitation (Preprint)

    Science.gov (United States)

    2015-06-01

    interaction. We use superscripts (en), (ei) and ( xd ) to denote electron-neutral, electron-ion (Coulomb), and excitation/dexcitation (as a whole...for each bound-bound transition and summed over all transitions to yield the total rates: K( xd ) = me ∑ ℓ ∑ u>ℓ ( κ↑(u|ℓ)nlne + κ ↓ (ℓ|u)nune ) (70a) J... xd ) = ∑ ℓ ∑ u>ℓ ( j↑(u|ℓ)nlne + j ↓ (ℓ|u)nune ) (70b) Based on the total frictional and thermal resistance coefficients, we can extract average

  5. Oceanography of the Grand Banks Region of Newfoundland, March 1974 - October 1974.

    Science.gov (United States)

    1978-07-01

    Sea in 1964. U.S. Coast Guard, Oceano - March 1971-December 1972. U.S. Coast Guard Ocean- graphic Report No. 10, CG 373-10. ographic Report No. 70, CG...60s00 08.30 34.S* a7?0 a000 £4. t0.. Gas Sol " a"’::0 34.:06 .0 44. SIR 00130 08.08 34.00 :1.0 0.00 £43. £.8 COO 00a 03.16 3.66 a70 9440.31 8 0 (0800

  6. The four hexamerin genes in the honey bee: structure, molecular evolution and function deduced from expression patterns in queens, workers and drones

    Directory of Open Access Journals (Sweden)

    Martins Juliana R

    2010-03-01

    Full Text Available Abstract Background Hexamerins are hemocyanin-derived proteins that have lost the ability to bind copper ions and transport oxygen; instead, they became storage proteins. The current study aimed to broaden our knowledge on the hexamerin genes found in the honey bee genome by exploring their structural characteristics, expression profiles, evolution, and functions in the life cycle of workers, drones and queens. Results The hexamerin genes of the honey bee (hex 70a, hex 70b, hex 70c and hex 110 diverge considerably in structure, so that the overall amino acid identity shared among their deduced protein subunits varies from 30 to 42%. Bioinformatics search for motifs in the respective upstream control regions (UCRs revealed six overrepresented motifs including a potential binding site for Ultraspiracle (Usp, a target of juvenile hormone (JH. The expression of these genes was induced by topical application of JH on worker larvae. The four genes are highly transcribed by the larval fat body, although with significant differences in transcript levels, but only hex 110 and hex 70a are re-induced in the adult fat body in a caste- and sex-specific fashion, workers showing the highest expression. Transcripts for hex 110, hex 70a and hex70b were detected in developing ovaries and testes, and hex 110 was highly transcribed in the ovaries of egg-laying queens. A phylogenetic analysis revealed that HEX 110 is located at the most basal position among the holometabola hexamerins, and like HEX 70a and HEX 70c, it shares potential orthology relationship with hexamerins from other hymenopteran species. Conclusions Striking differences were found in the structure and developmental expression of the four hexamerin genes in the honey bee. The presence of a potential binding site for Usp in the respective 5' UCRs, and the results of experiments on JH level manipulation in vivo support the hypothesis of regulation by JH. Transcript levels and patterns in the fat body

  7. Lawrence Berkeley laboratory neutral-beam engineering test facility power-supply system

    International Nuclear Information System (INIS)

    Lutz, I.C.; Arthur, C.A.; deVries, G.J.; Owren, H.M.

    1981-10-01

    The Lawrence Berkeley Laboratory is upgrading the neutral beam source test facility (NBSTF) into a neutral beam engineering test facility (NBETF) with increased capabilities for the development of neutral beam systems. The NBETF will have an accel power supply capable of 170 kV, 70 A, 30 sec pulse length, 10% duty cycle; and the auxiliary power supplies required for the sources. This paper describes the major components, their ratings and capabilities, and the flexibility designed to accomodate the needs of source development

  8. Eficacia del plasma rico en plaquetas en procedimientos médicos estéticos faciales . Evaluación en contorno de ojos.

    OpenAIRE

    Cepeda Páez, Katerine Andrea

    2014-01-01

    Introducción: En la actualidad se están implementando nuevas técnicas, para el tratamiento de líneas de expresión facial. El Plasma Rico en Plaquetas (PRP) utiliza factores de crecimiento humano autólogos con fines médicos estéticos. El objetivo de este trabajo fue evaluar el tratamiento con plasma rico en plaquetas en el manejo del rejuvenecimiento periocular. Materiales y métodos: Estudio descriptivo retrospectivo en una cohorte de 27 pacientes entre 30 a 70 años de ambos sexos,trata...

  9. Electron temperature effects for an ion beam source

    International Nuclear Information System (INIS)

    Uramoto, Joshin.

    1979-05-01

    A hydrogen high temperature plasma up to 200 eV is produced by acceleration of electrons in a hot hollow cathode discharge and is used as an ion beam source. Then, two characteristics are observed: A rate of the atomic ion (H + ) number increases above 70%. A perveance of the ion beam increases above 30 times compared with that of a cold plasma, while a floating potential of an ion acceleration electrode approaches an ion acceleration potential (- 500 V) according as an increment of the electron temperature. Moreover, a neutralized ion beam can be produced by only the negative floating electrode without an external power supply. (author)

  10. Eversión vesical completa a través de una fístula vesicovaginal

    OpenAIRE

    Jhoan Aragón Charry; Eduardo Reyna Villasmil; Joel Santos Bolívar

    2013-01-01

    La eversión vesical completa es rara. Se presenta el caso de una eversión de vejiga urinaria a través de una fístula vesicovaginal acompañada de prolapso útero-vaginal concurrente. Se trata de paciente de 70 años que presentó una tumoración compatible con un prolapso vaginal grado IV y una tumoración edematosa, pegajosa y piriforme por delante del prolapso compatible con la vejiga con un orificio en la pared anterior de la vagina a través del cual la mucosa de la vejiga estaba evertida, proc...

  11. Factores pronósticos en el tratamiento adyuvante del cáncer de vejiga

    OpenAIRE

    Pardo Aranda, Nuria

    2013-01-01

    El cáncer de vejiga es el cuarto tumor más frecuente en hombres. En este estudio se recogen 70 pacientes diagnosticados de carcinoma urotelial resecables en el Hospital Germans Trias y Pujol(1994 -2011). El objetivo es analizar que factores pronósticos determinan la realización del tratamiento adyuvante.La edad fue un factor pronóstico: menores de 70 años alcanzaban una mediana de supervivencia de 77 meses.Pacientes sin afectación ganglionar tenían una mediana de supervivencia de 77 meses fre...

  12. Performance of a modified DuoPIGatron ion source for PLT neutral beam injectors

    International Nuclear Information System (INIS)

    Tsai, C.C.; Stirling, W.L.; Haselton, H.H.

    1978-09-01

    The performance of a modified duoPIGatron ion source for PLT neutral beam injectors is described. The 22-cm source has been operated to deliver beams of 70 A, up to 45 keV, and 0.5 sec. Following a brief review of source operation, the dominant reactions leading to an enhanced atomic ion fraction in the source plasma are emphasized. In addition to the high atomic ion species yield (about 85%), other important characteristics of the source such as high arc efficiency (about 1.1 A ion beam current per kW of arc power), long filament lifetime, high reliability, and scalability are also described

  13. The four hexamerin genes in the honey bee: structure, molecular evolution and function deduced from expression patterns in queens, workers and drones

    Science.gov (United States)

    2010-01-01

    Background Hexamerins are hemocyanin-derived proteins that have lost the ability to bind copper ions and transport oxygen; instead, they became storage proteins. The current study aimed to broaden our knowledge on the hexamerin genes found in the honey bee genome by exploring their structural characteristics, expression profiles, evolution, and functions in the life cycle of workers, drones and queens. Results The hexamerin genes of the honey bee (hex 70a, hex 70b, hex 70c and hex 110) diverge considerably in structure, so that the overall amino acid identity shared among their deduced protein subunits varies from 30 to 42%. Bioinformatics search for motifs in the respective upstream control regions (UCRs) revealed six overrepresented motifs including a potential binding site for Ultraspiracle (Usp), a target of juvenile hormone (JH). The expression of these genes was induced by topical application of JH on worker larvae. The four genes are highly transcribed by the larval fat body, although with significant differences in transcript levels, but only hex 110 and hex 70a are re-induced in the adult fat body in a caste- and sex-specific fashion, workers showing the highest expression. Transcripts for hex 110, hex 70a and hex70b were detected in developing ovaries and testes, and hex 110 was highly transcribed in the ovaries of egg-laying queens. A phylogenetic analysis revealed that HEX 110 is located at the most basal position among the holometabola hexamerins, and like HEX 70a and HEX 70c, it shares potential orthology relationship with hexamerins from other hymenopteran species. Conclusions Striking differences were found in the structure and developmental expression of the four hexamerin genes in the honey bee. The presence of a potential binding site for Usp in the respective 5' UCRs, and the results of experiments on JH level manipulation in vivo support the hypothesis of regulation by JH. Transcript levels and patterns in the fat body and gonads suggest that

  14. Evaluación de tres estrategias para la captación de mujeres con cribado incorrecto de cáncer de cérvix: Estudio CRICERVA

    OpenAIRE

    Acera Pérez, Amèlia

    2016-01-01

    El cribado regular para el cáncer cervical ha demostrado reducir la incidencia y la mortalidad por esta enfermedad. El objetivo de este estudio fue mejorar la participación y la cobertura del cribado de cáncer de cérvix en las mujeres de 30 a 70 años, evaluar el impacto en la cobertura y conocer las características (lugar y periodicidad) de la misma, tras invitación personalizada en tres formas diferentes dirigida a las mujeres que en nuestra base de datos constaba una ausencia de cribado o u...

  15. Estilo de afrontamiento, optimismo disposicional, depresión, imagen corporal, imc, y riesgo de tca como predictores de calidad de vida relacionada con la salud

    OpenAIRE

    Londoño, Constanza; UNIVERSIDAD CATÓLICA DE COLOMBIA; Velasco, Ruth; UNIVERSIDAD CATOLICA DE COLOMBIA

    2015-01-01

    Esta investigación tenía como objetivo determinar si el estilo de afrontamiento, el optimismo disposicional, la depresión, la imagen corporal, el riesgo de padecer un trastorno de conducta alimentaria, el índice de masa corporal y la edad, en interacción, predicen la calidad de vida relacionada con la salud en una muestra de 411 personas de 15 a 70 años. Se utilizó el Cuestionario de Estilos de Afrontamiento, el Cuestionario de optimismo disposicional, el Cuestionario Beck de depresión segund...

  16. Estilo de afrontamiento, optimismo disposicional, depresión, imagen corporal, IMC, y riesgo de TCA como predictores de calidad de vida relacionada con la salud

    OpenAIRE

    Londoño Pérez, Constanza; Velasco Salamanca, Marcela

    2015-01-01

    Esta investigación tenía como objetivo determinar si el estilo de afrontamiento, el optimismo disposicional, la depresión, la imagen corporal, el riesgo de padecer un trastorno de conducta alimentaria, el índice de masa corporal y la edad, en interacción, predicen la calidad de vida relacionada con la salud en una muestra de 411 personas de 15 a 70 años. Se utilizó el Cuestionario de Estilos de Afrontamiento, el Cuestionario de optimismo disposicional, el Cuestionario Beck de depresión segund...

  17. Additive pressure dependence of the superconducting transition temperature by Th-Y alloys

    International Nuclear Information System (INIS)

    Huber, J.G.

    1980-01-01

    The T/sub c/ at zero pressure of solid solution Th-Y alloys increases with Y concentration from the pure Th value to a maximum at 20 a/o Y and then decreases until disappearing at 70 a/o Y. The application of pressure P depresses the T/sub c/ of pure Th (negative dT/sub c//dP), while for pure Y a T/sub c/ eventually appears with a dT/sub c//dP which is positive

  18. Ortodoncia en adultos

    Directory of Open Access Journals (Sweden)

    Hidalgo B. Ester, Dra.M

    2013-11-01

    Full Text Available Existe la creencia de que los tratamientos de ortodoncia sólo se pueden realizar en adolescentes. Desde la década del 70, a nivel internacional y nacional cada vez más son los adultos que están dispuestos a tener frenillos para solucionar su problema. En este artículo se describe la motivación del paciente, indicaciones y contraindicaciones de tratamiento, limitación de los resultados, tipos de aparatos usados y se presentan casos clínicos. Se concluye que no existe límite de edad para realizar tratamientos de ortodoncia en adultos.

  19. Structural Characterization of the Molecular Events during a Slow Substrate-Product Transition in Orotidine 5'-Monophosphate Decarboxylase

    Energy Technology Data Exchange (ETDEWEB)

    Fujihashi, Masahiro; Wei, Lianhu; Kotra, Lakshmi P; Pai, Emil F; (TGRI); (Toronto); (Kyoto)

    2009-04-06

    Crystal structures of substrate-product complexes of Methanobacterium thermoautotrophicum orotidine 5'-monophosphate decarboxylase, obtained at various steps in its catalysis of the unusual transformation of 6-cyano-uridine 5'-monophosphate (UMP) into barbituric acid ribosyl monophosphate, show that the cyano substituent of the substrate, when bound to the active site, is first bent significantly from the plane of the pyrimidine ring and then replaced by an oxygen atom. Although the K72A and D70A/K72A mutants are either catalytically impaired or even completely inactive, they still display bending of the C6 substituent. Interestingly, high-resolution structures of the D70A and D75N mutants revealed a covalent bond between C6 of UMP and the Lys72 side chain after the -CN moiety's release. The same covalent bond was observed when the native enzyme was incubated with 6-azido-UMP and 6-iodo-UMP; in contrast, the K72A mutant transformed 6-iodo-UMP to barbituric acid ribosyl 5'-monophosphate. These results demonstrate that, given a suitable environment, native orotidine 5'-monophosphate decarboxylase and several of its mutants are not restricted to the physiologically relevant decarboxylation; they are able to catalyze even nucleophilic substitution reactions but consistently maintain distortion on the C6 substituent as an important feature of catalysis.

  20. Recurrent SETBP1 mutations in atypical chronic myeloid leukemia

    Science.gov (United States)

    Piazza, Rocco; Valletta, Simona; Winkelmann, Nils; Redaelli, Sara; Spinelli, Roberta; Pirola, Alessandra; Antolini, Laura; Mologni, Luca; Donadoni, Carla; Papaemmanuil, Elli; Schnittger, Susanne; Kim, Dong-Wook; Boultwood, Jacqueline; Rossi, Fabio; Gaipa, Giuseppe; De Martini, Greta P; di Celle, Paola Francia; Jang, Hyun Gyung; Fantin, Valeria; Bignell, Graham R; Magistroni, Vera; Haferlach, Torsten; Pogliani, Enrico Maria; Campbell, Peter J; Chase, Andrew J; Tapper, William J; Cross, Nicholas C P; Gambacorti-Passerini, Carlo

    2013-01-01

    Atypical chronic myeloid leukemia (aCML) shares clinical and laboratory features with CML, but it lacks the BCR-ABL1 fusion. We performed exome sequencing of eight aCMLs and identified somatic alterations of SETBP1 (encoding a p.Gly870Ser alteration) in two cases. Targeted resequencing of 70 aCMLs, 574 diverse hematological malignancies and 344 cancer cell lines identified SETBP1 mutations in 24 cases, including 17 of 70 aCMLs (24.3%; 95% confidence interval (CI) = 16–35%). Most mutations (92%) were located between codons 858 and 871 and were identical to changes seen in individuals with Schinzel-Giedion syndrome. Individuals with mutations had higher white blood cell counts (P = 0.008) and worse prognosis (P = 0.01). The p.Gly870Ser alteration abrogated a site for ubiquitination, and cells exogenously expressing this mutant exhibited higher amounts of SETBP1 and SET protein, lower PP2A activity and higher proliferation rates relative to those expressing the wild-type protein. In summary, mutated SETBP1 represents a newly discovered oncogene present in aCML and closely related diseases. PMID:23222956

  1. Efectos a corto plazo de la contaminación atmosférica sobre la mortalidad: resultados del proyecto EMECAM en el gran Bilbao

    Directory of Open Access Journals (Sweden)

    Cambra Contín Koldo

    1999-01-01

    Full Text Available FUNDAMENTO: Los objetivos de este estudio han sido evaluar los efectos a corto plazo de la contaminación atmosférica por dióxido de azufre (SO2, partículas, dióxido de nitrógeno (NO2 y humos negros en la mortalidad diaria en el Gran Bilbao. MÉTODOS: Se ha seguido la metodología del proyecto EMECAM. RESULTADOS: Los incrementos de PST, tanto en valores máximos horarios como medios diarios, se asocian significativamente con la mortalidad por todas las causas, por causa circulatoria y en mayores de 70 años. No se han observado diferencias por semestres. Los aumentos en los niveles medios de NO2 se asocian a aumentos de mortalidad por causa respiratoria en todo el período y en período cálido y en mayores de 70 años en el semestre frío. CONCLUSIONES: Los niveles actuales de partículas en suspensión en el Gran Bilbao están asociados con aumentos significativos en la mortalidad. Las asociaciones encontradas entre NO2 y las muertes por causa respiratoria, muy altas principalmente en el período cálido, requieren investigaciones adicionales que valoren su independencia.

  2. Influences of arc current on composition and properties of MgO thin films prepared by cathodic vacuum arc deposition

    International Nuclear Information System (INIS)

    Zhu Daoyun; Zheng Changxi; Wang Mingdong; Liu Yi; Chen Dihu; He Zhenhui; Wen Lishi; Cheung, W.Y.

    2010-01-01

    MgO thin films with high optical transmittances (more than 90%) were prepared by cathodic vacuum arc deposition technique. With the increase of arc current from 40 to 80 A, the deposition pressure decreases and the film thickness increases; the atomic ratio of Mg/O in MgO thin films (obtained by RBS) increases from 0.97 to 1.17, giving that deposited at 50 A most close to the stoichiometric composition of the bulk MgO; the grains of MgO thin films grow gradually as shown in SEM images. XRD patterns show that MgO (1 1 0) orientation is predominant for films prepared at the arc currents ranged from 50 to 70 A. The MgO (1 0 0) orientation is much enhanced and comparable to that of MgO (1 1 0) for films prepared at the arc current of 80 A. The secondary electron emission coefficient of MgO thin film increases with arc current ranged from 50 to 70 A.

  3. Effects of current crowding on light extraction efficiency of conventional GaN-based light-emitting diodes.

    Science.gov (United States)

    Cao, Bin; Li, Shuiming; Hu, Run; Zhou, Shengjun; Sun, Yi; Gan, Zhiying; Liu, Sheng

    2013-10-21

    Current crowding effects (CCEs) on light extraction efficiency (LEE) of conventional GaN-based light-emitting diodes (LEDs) are analyzed through Monte Carlo ray-tracing simulation. The non-uniform radiative power distribution of the active layer of the Monte Carlo model is obtained based on the current spreading theory and rate equation. The simulation results illustrate that CCE around n-pad (n-CCE) has little effect on LEE, while CCE around p-pad (p-CCE) results in a notable LEE droop due to the significant absorption of photons emitted under p-pad. LEE droop is alleviated by a SiO₂ current blocking layer (CBL) and reflective p-pad. Compared to the conventional LEDs without CBL, the simulated LEE of LEDs with CBL at 20 A/cm² and 70 A/cm² is enhanced by 7.7% and 19.0%, respectively. It is further enhanced by 7.6% and 11.4% after employing a reflective p-pad due to decreased absorption. These enhancements are in accordance with the experimental results. Output power of LEDs with CBL is enhanced by 8.7% and 18.2% at 20 A/cm² and 70 A/cm², respectively. And the reflective p-pad results in a further enhancement of 8.9% and 12.7%.

  4. Controlled dissolution of silicon dioxide layers for depth resolved multielement analysis by inductively coupled plasma-mass spectrometry

    International Nuclear Information System (INIS)

    Lorge, Susan E.; Houk, R.S.

    2009-01-01

    Dissolution procedures were developed to control the number of surface layers removed, in an attempt to achieve depth resolved analysis by inductively coupled plasma-mass spectrometry (ICP-MS). NIST 612 glass was chosen because it is a homogeneous material with many elements at interesting concentrations, ∼ 50 ppm. Varying dissolution time and HF concentration resulted in the reproducible removal of SiO 2 layers as thin as 70 A deep. Dissolved trace metals were determined after dilution by inductively coupled plasma-mass spectrometry (ICP-MS) with a magnetic sector instrument. The amount removed was determined from the concentration of a major element, Ca. With the exception of Zn, trace metal concentrations agreed reasonably well with their certified values for removal depths of 500, 300 and 150 A. Zinc concentration was significantly high in all dissolutions indicating either a contamination problem or that Zn is removed at a faster rate than Ca. For the dissolutions that removed 70 A of SiO 2 , Cr, Mn, Co, Sr, Cd, Ce, Dy, Er, Yb and U recovery results agreed with their certified values (∼ 50 ppm); Ti, As, Mo, Ba, and Th could not be determined because net intensities were below 3σ of the blank; and measured concentrations for Cu, Pb and Zn were well above the certified values.

  5. Outcomes From AAS Hack Day at the 227th AAS Meeting

    Science.gov (United States)

    Kohler, Susanna

    2016-01-01

    Editors Note:This is a final post from the 227th AAS Meeting in Kissimmee, FL. This special summary of AAS Hack Day, a meeting of AAS members to collaboratively work on various small projects, was written by Meredith Rawls (@Merrdiff) and was originally posted on astrobites.com.As the 227thAmerican Astronomical Society meeting drew to a close (see highlights from Day 1, Day 2, Day 3, and Day 4), a group of at least 50 attendees spent Day 4working on small projects fondly called hacks. Thanks to sponsorship from LSST and Northrup Grumman, the industrious hackers werewell-caffeinated and fed so we could devote time and energy toworking in groups on one-day projects.TheHack Day beganat 10am with pitches. Anybody with a project idea was welcome to briefly speak and try to convince others to work with them. Only someideas panned out, but the enthusiasm was palpable. Its not every day you get a full room of astronomers and affiliates eager to spend hours working on fun and useful projects to benefit the community.#hackAAS is getting underway! #aas227 pic.twitter.com/yX7jlOnSCK James R A Davenport (@jradavenport) January 8, 2016Here is a rundown of what we accomplished. Pretty impressive for a single day! Many thanks to fellow astrobiter Erika Nesvold (now at Carnegie DTM; @erikanesvold) whose hack was live-documenting all the other hacks. Her tweets as @astrobites appeared with the #hackaas hashtag, and her notes made this recap post infinitely easier to write.Interested in joining the fun? Sign up for Hack Day at the 2017 JanuaryAAS meeting (its free with meeting registration), and consider applying for the .Astronomy conference this summer.Towards Optimal Session Scheduling:Adrian Price-Whelan (Columbia), David Hogg (NYU), and Scott Idem (AAS) began writing a program to take all submitted abstracts to a conference like AAS and sort them using keywords to avoid scheduling similar talks in parallel sessions. Its impossible to make everyone happy, but minimizing conflicts

  6. Efectos a corto plazo de la contaminación atmosférica sobre la mortalidad: resultados del proyecto EMECAM en Zaragoza, 1991-1995

    Directory of Open Access Journals (Sweden)

    Arribas Monzón Federico

    1999-01-01

    Full Text Available FUNDAMENTO: Evaluar el impacto a corto plazo de la contaminación sobre la mortalidad respiratoria en la ciudad de Zaragoza, en el periodo1991-95, e identificar si hay diferencias en función de la edad y época del año. MÉTODOS: La asociación de concentraciones diarias de humos y SO2 con las defunciones diarias por enfermedades respiratorias (CIE-9 460-486 y enfermedad pulmonar obstructiva crónica y afines EPOC-EA (490-496, se analizó aplicando modelos de Poisson, siguiendo el protocolo del proyecto EMECAM. Se investigaron posibles diferencias del efecto en mayores y menores de 70 años y según semestre. Se calcularon riesgos relativos (RR e intervalos de confianza al 95% (IC95% para incrementos de contaminante de 10 m gr/m³. RESULTADOS: Se encontró asociación entre mortalidad respiratoria y humos (RR 1,028 IC95%1,006-1,051, siendo el riesgo mayor en semestre cálido. En mayores de 70 años, la relación se mantuvo en este semestre y fue negativa en menores de 70. Los RRs de la mortalidad por EPOC-EA fueron globalmente de 1,038 (IC95%1,002-1,075 y de 1,068 (IC95%: 1,004-1,137 para el semestre cálido. La contaminación por SO2 mostró asociación positiva con la mortalidad respiratoria en periodo cálido para todas las edades, RR 1,093 (IC95%: 1,006-1,187 y en menores de 70 años (RR 1,240 IC95%: 1,028-1,496. Los efectos fueron no concluyentes con las neumonías. CONCLUSIONES: Niveles bajos de contaminación atmosférica pueden producir efectos significativos en la mortalidad respiratoria, especialmente personas mayores durante los semestres cálidos.

  7. U.S./Russian cooperative efforts to enhance nuclear MPC ampersand A at VNIITF, (Chelyabinsk-70)

    International Nuclear Information System (INIS)

    Abramson, B; Apt, K; Blasy, J; Bukin, D; Churikov, Y; Curtis, D; Eras, A; Magda, E; Neymotin, L; Shultz, F; Slankas, T; Tittemore, G; Tsygankov, G; Zuev, V.

    1999-01-01

    The work described here is part of an effort called the Nuclear Materials Protection, Control, and Accounting (MPC ampersand A) Program, a cooperative program between the US Department of Eenrgy (DOE) and Russia's Ministry of Atomic Energy (MinAtom). The objective of the program is to reduce the risk of nuclear proliferation by strengthening MPC ampersand A systems at Russian nuclear Facilities. This paper describes that portion of the MPC ampersand A program that is directed specifically to the needs of the All Russian Scientific Research Institute of Technical Physics (VNIITF), also called Chelyabinsk-70. A major MPC ampersand A milestone was met at VNIITF when the MPC ampersand A improvements were commissioned at the Pulse Research Reactor Facility in May of this year

  8. Design of Experiments to Determine Causes of Flex Cable Solder Wicking, Discoloration and Hole Location Defects

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, Larry

    2009-04-22

    Design of Experiments (DoE) were developed and performed in an effort to discover and resolve the causes of three different manufacturing issues; large panel voids after Hot Air Solder Leveling (HASL), cable hole locations out of tolerance after lamination and delamination/solder wicking around flat flex cable circuit lands after HASL. Results from a first DoE indicated large panel voids could be eliminated by removing the pre-HASL cleaning. It also revealed eliminating the pre-HASL bake would not be detrimental when using a hard press pad lamination stackup. A second DoE indicated a reduction in hard press pad stackup lamination pressure reduced panel stretch in the y axis approximately 70%. A third DoE illustrated increasing the pre-HASL bake temperature could reduce delamination/solder wicking when using a soft press pad lamination stackup.

  9. Teorias do neo-imperialismo: raízes da teoria marxista do capitalismo mundial The neo-imperialism theories: the roots for the marxist theory of the world capitalism

    OpenAIRE

    Alex Fiuza de Mello

    2007-01-01

    O texto faz uma incursão em várias interpretações elaboradas a partir dos anos 60-70 a respeito dos dilemas - ainda sem solução - que emanam das mudanças substanciais que o mundo vem sofrendo nos campos da economia, da política e da cultura no final do século passado e início deste. A questão essencial é a seguinte: ainda vivemos o estágio histórico do imperialismo ou a humanidade já ingressa numa outra etapa do processo de desenvolvimento do capitalismo, qualitativamente distinta da preceden...

  10. Hydrogen and helium recycling from a JxB-force convected liquid metal Ga{sub 67}In{sub 20.5}Sn{sub 12.5} under steady state plasma bombardment

    Energy Technology Data Exchange (ETDEWEB)

    Hirooka, Yoshi, E-mail: hirooka.yoshihiko@nifs.ac.jp [National institute for Fusion Science, Oroshi, Toki, Gifu 509-5292 (Japan); Graduate University for Advanced Studies, Oroshi, Toki, Gifu 509-5292 (Japan); Bi, Hailin [Graduate University for Advanced Studies, Oroshi, Toki, Gifu 509-5292 (Japan); Shimada, Michiya [Japan Atomic Energy Agency, Rokkasho, Kamikita, Aomori 039-3212 (Japan); Ono, Masa [Princeton Plasma Physics Laboratory, Princeton, NJ 08543 (United States)

    2017-04-15

    A series of first-of-a-kind laboratory-scale experiments on the JxB-force convected liquid metal divertor concept have been carried out in the temperature range from room temperature to ∼200 °C, employing a eutectic alloy: Ga{sub 67}In{sub 20.5}Sn{sub 12.5}, the melting point of which is 10.5 °C. The electrical current conducted through the alloy is set at about 70A and the magnetic field is set at about 700 G. It has reproducibly been observed that hydrogen as well as helium particle recycling is noticeably reduced under steady state plasma bombardment when the liquid is convected by the JxB force.

  11. Comparison of MgB2 and Coated Conductor Based 5 MW Superconducting Wind Turbine Generator

    DEFF Research Database (Denmark)

    Abrahamsen, Asger Bech; Jensen, Bogi Bech

    2012-01-01

    conductors, but the operation temperature in range of T = 15-20 K and the engineering current density Je is smaller. We have found that a 16 pole synchronous generator with active diameter D = 4.2 m and length L = 1.5 m based on a MgB2 wire with Je = 70 A/mm2 in approximately 4 Tesla field would result...... in a wire usage in the order of 330 km. This has the potential to decrease the price of the superconductor wires in the generator by a factor of 10 compared to the coated conductors, but the cryogenics will be a challenge and is discussed. Finally we will use turbine load simulations to discuss the torque...... events that such a 5 MW generator would experience if installed in the NREL turbine....

  12. مطالعه بر روی ایمنی زایی یک واکسن آزمایشی سپتی سمی هموراژیک با ادجوان روغنی در گاو

    Directory of Open Access Journals (Sweden)

    ا. ستوده نیا

    2005-01-01

    Full Text Available An oil adjuvant vaccine (OAV was prepared from a local strain of Pasteurella multocida. Strain 6:B was cultured and inactivated by formalin. Bacterial pellet was prepared by centrifugation and subsequently adjuvanted by Montannide oil ISA-70. A dose of prepared vaccine containing 3ml (2mg dry weight/ml was injected into five calves by IM route. Animals were bled before and at 24, 90, 150, and 200 days post-vaccination. Collected sera were used in passive mouse protection test (PMPT. Active mouse protection test (AMPT was carried out for OAV according to standard method. Results of PMPT showed 100% protection up to 150 days and 66-83% up to 200 days post-vaccination. In AMPT, 4 log of protection was gained. In this experiment the immunity induced by OAV adjuvanted by ISA-70 could protect the calves.

  13. Ten years after the IOM report: Engaging residents in quality and patient safety by creating a House Staff Quality Council.

    Science.gov (United States)

    Fleischut, Peter M; Evans, Adam S; Nugent, William C; Faggiani, Susan L; Lazar, Eliot J; Liebowitz, Richard S; Forese, Laura L; Kerr, Gregory E

    2011-01-01

    Ten years after the 1999 Institute of Medicine report, it is clear that despite significant progress, much remains to be done to improve quality and patient safety (QPS). Recognizing the critical role of postgraduate trainees, an innovative approach was developed at New York-Presbyterian Hospital, Weill Cornell Medical Center to engage residents in QPS by creating a Housestaff Quality Council (HQC). HQC leaders and representatives from each clinical department communicate and partner regularly with hospital administration and other key departments to address interdisciplinary quality improvement (QI). In support of the mission to improve patient care and safety, QI initiatives included attaining greater than 90% compliance with medication reconciliation and reduction in the use of paper laboratory orders by more than 70%. A patient safety awareness campaign is expected to evolve into a transparent environment where house staff can openly discuss patient safety issues to improve the quality of care.

  14. Acute pancreatitis: clinical vs. CT findings

    International Nuclear Information System (INIS)

    Hill, M.C.; Barkin, J.; Isikoff, M.B.; Silver stein, W.; Kalser, M.

    1982-01-01

    In a prospective study of 91 patients with acute pancreatitis, computed tomographic (CT) findings were correlated with the clinical type of acute pancreatitis. In acute edematous pancreatitis (63 patients; 16 with repeat CT), CT was normal (28%) or showed inflammation limited to the pancreas (61%). Phlegmonous changes were present in 11%, including one patient with focal pancreatic hemorrhage, indicating that clinically unsuspected hemorrhagic pancreatitis can occur. In acute necrotizing (hemorrhagic, suppurative) pancreatitis (nine patients; eight with repeat CT), no patient had a normal CT scan and 89% had phlegmonous changes. One patient had hemorrhagic pancreatitis and three had abscesses. In acute exacerbation of chronic pancreatitis (10 patients; three with repeat CT), there were pancreatic calcifications (70%), a focal mass (40%), and pancreatic ductal dilation (30%). On follow-up CT, the findings of acute pancreatitis did not always disappear with resolution of the clinical symptons. This was especialy true of phlegmonous pancreatitis, where the CT findings could persist for months

  15. Multichannel Thomson scattering apparatus

    International Nuclear Information System (INIS)

    Bretz, N.; Dimock, D.; Foote, V.; Johnson, D.; Long, D.; Tolnas, E.

    1977-07-01

    A Thomson scattering apparatus for measuring the electron temperature and density along a 90 cm diameter of the PLT plasma has been built. A wide angle objective images the 3 mm x 900 mm ruby laser beam onto an image dissector which rearranges the 300 : 1 image to 20 : 1 forming the input slit of a spectrometer. The stigmatic spectrometer provides 20 wavelength elements of approximately 70 A each. A micro-channel-plate image intensifier optically coupled to a cooled SIT tube provides detection with single frame linearity and 1000 : 1 dynamic range. Spatial profiles of N/sub e/ and T/sub e/ in the range 10 13 - 10 14 cm -3 and 0.05 - 3 keV have an accuracy of 30 √10 13 /N/sub e/ (cm -3 ) percent per 1.2 cm element

  16. JINR rapid communications

    International Nuclear Information System (INIS)

    1996-01-01

    The present collection of rapid communications from JINR, Dubna, contains seven separate reports on the identification of events with a secondary vertex in the experiment EXCHARM, the zero degree calorimeter for CERN WA-98 experiment, a new approach to increase the resource of installation elements for super-high energy physics, a method of the in-flight production of exotic systems in the charge-exchange reactions, the neutron activation analysis for monitoring northern terrestrial ecosystems, a search for 28 O and study of the neutron-rich nuclei near the neutron closure N=20, a search for new neutron-rich nuclei with a 70A MeV 48 Ca beam. 33 figs., 4 tabs

  17. El alzamiento de Pascuas de 1916

    OpenAIRE

    Cruset, María Eugenia

    2006-01-01

    Hay algunos hechos en la historia que son particularmente gráficos. Si uno piensa en la caida del Muro de Berlín en 1989, en seguida le llega a la mente el fin de los 70 años del experimento socialista soviético. Del mismo modo, si recordamos la Revuelta de Pascua de 1916 podemos visualizar el fin de siglos de dominio inglés sobre Irlanda. Y, aunque estrictamente hablando, esto recién será el comienzo del fin, su carácter simbólico y su utilización como ícono nacionalista, nos permitirá hacer...

  18. Inhibitory effects of food additives derived from polyphenols on staphylococcal enterotoxin A production and biofilm formation by Staphylococcus aureus.

    Science.gov (United States)

    Shimamura, Yuko; Hirai, Chikako; Sugiyama, Yuka; Shibata, Masaharu; Ozaki, Junya; Murata, Masatsune; Ohashi, Norio; Masuda, Shuichi

    2017-12-01

    In this study, we examined the inhibitory effects of 14 food additives derived from polyphenol samples on staphylococcal enterotoxin A (SEA) production and biofilm formation by Staphylococcus aureus. Tannic acid AL (TA), Purephenon 50 W (PP) and Polyphenon 70A (POP) at 0.25 mg/mL and Gravinol®-N (GN), Blackcurrant polyphenol AC10 (BP), and Resveratrol-P5 (RT) at 1.0 mg/mL significantly decreased SEA production by S. aureus C-29 (p Food additives derived from polyphenols have viability to be used as a means to inhibit the enterotoxin production and control the biofilm formation of foodborne pathogens.

  19. Angular dependencies of longitudinal magnetoresistivity and planar Hall effect of single and multilayered thin films

    International Nuclear Information System (INIS)

    Ko, T.W.; Lee, J.H.; Park, B.K.; Rhie, K.; Jang, P.W.; Hwang, D.G.; Lee, S.S.; Kim, M.Y.; Rhee, J.R.

    1998-01-01

    Magnetoresistivity and planar Hall effect of a Glass/Fe70A/[Co21A/Cu25A] 20 multilayer coupled antiferromagnetically a single layer (Co81Nb19) thin film, and NiO based Glass/Ni350A/Py50A/Cu20A/Py50A (Py = Ni 83 Fe 17 ) spin value are studied. Planar Hall resistivity is analysed concurrently with the resistivity of the sample. With variation of direction and strength of the applied fields, we found that the magnetization process affects significantly the planar Hall effect. We developed a simple method to find the easy axis of single layer magnetic thin films. We also observed the variation of magnetization of each layer separately for an antiferromagnetically coupled multilayer, and a NiO-based spin value with the planar Hall effect. (author)

  20. Neutron-scattering studies of the S=2 antiferromagnetic chain MnCl sub 3 (C sub 1 sub 0 D sub 8 N sub 2)

    CERN Document Server

    Granroth, G E; Coldea, R; Eccleston, R S; Ward, B H; Talham, D R; Meisel, M W

    2002-01-01

    Quasi-elastic and inelastic neutron scattering studies of the quasi-one-dimensional S=2 antiferromagnet MnCl sub 3 (C sub 1 sub 0 D sub 8 N sub 2) are reported. The quasi-elastic measurements exhibit a broad peak at Q approx 0.69 A sup - sup 1 , which is consistent with short-range antiferromagnetic coupling between neighboring Mn sup 3 sup + ions. Inelastic experiments, at 150 mK and Q=0.70 A sup - sup 1 , reveal decreased magnetic scattering at energies less than 0.2 meV when compared to similar studies at 20 K. These results provide microscopic evidence for the presence of a Haldane gap and are consistent with the bulk magnetization measurements of Granroth et al. (orig.)

  1. Neutron-scattering studies of the S=2 antiferromagnetic chain MnCl3(C10D8N2)

    International Nuclear Information System (INIS)

    Granroth, G.E.; Nagler, S.E.; Coldea, R.; Eccleston, R.S.; Ward, B.H.; Talham, D.R.; Meisel, M.W.

    2002-01-01

    Quasi-elastic and inelastic neutron scattering studies of the quasi-one-dimensional S=2 antiferromagnet MnCl 3 (C 10 D 8 N 2 ) are reported. The quasi-elastic measurements exhibit a broad peak at Q∼0.69 A -1 , which is consistent with short-range antiferromagnetic coupling between neighboring Mn 3+ ions. Inelastic experiments, at 150 mK and Q=0.70 A -1 , reveal decreased magnetic scattering at energies less than 0.2 meV when compared to similar studies at 20 K. These results provide microscopic evidence for the presence of a Haldane gap and are consistent with the bulk magnetization measurements of Granroth et al. (orig.)

  2. Temporal lobe epilepsy: Comparison of CT and MR in 100 patients

    International Nuclear Information System (INIS)

    Schoerner, W.; Meencke, H.J.; Sander, B.; Henkes, H.; Felix, R.; Klinikum Rudolf Virchow, Berlin

    1989-01-01

    The value of CT and MR was studied in 100 patients with temporal lobe epilepsy. Axial CT scans were obtained before and after contrast injection. Coronary MR scans were carried out with T 1 -(SE 400/30, GE 315/14) and T 2 -weighted sequences (SE 1600/30 + 70). A circumscribed lesion was demonstrated in fifteen patients by CT and in 25 patients by MR. With the exception of a small area of calcification, all lesions seen on CT could also be recognized on MR. Better sensitivity and improved demonstration of the temporal lobes makes MR the method of choice in the diagnosis of temporal lobe epilepsy. (orig./GDG) [de

  3. Control-grid electron gun as a source of modulated electron beam for a collective accelerator

    International Nuclear Information System (INIS)

    Bakumenko, A.A.; Belikov, V.V.; Zvyagintsev, A.V.; Lyul'chenko, V.I.; Lymar', A.G.; Martynenko, P.A.; Suryadnyj, A.V.

    1989-01-01

    Structure is described and experimental results of investigations into an electron gun with transverse beam compression and control grid are presented. The pulse trailing edge is formed by a sectioned discharger. A modulated electron beam with the following parameters: 110 keV beam energy, 70 A current amplitude, 3-8 MHz modulation frequency, 100% modulation depth, ≅8-6 mm minimal beam diameter, ≅ 10μs pulse duration, 3% pulse top non-uniformity, more than 200 compression degree is obtained when introducing the positive feedback in auto-generator regime to the gun supply circuit. Further it is supposed to use the developed electron gun for heavy ion acceleration by a field of space charge of a modulated electron beam in a corrugated liner. It should be underlined that power supply of such an accelerator does not require powerful outside HF generator. 5 refs.; 1 fig

  4. AVANCES EN REGENERACIÓN AUDITIVA. ESTADO ACTUAL Y PERSPECTIVAS FUTURAS

    OpenAIRE

    Dr. Juan Cristóbal Maass, PhD; Dra. Francisca Hanuch; Dra. Macarena Ormazábal

    2016-01-01

    La sordera es uno de los defectos congénitos más frecuentes en el mundo y puede llegar a alcanzar hasta un 50% en los adultos mayores de 70 años. La mayor parte de la pérdida de audición se produce por daño en las células ciliadas (CC), que son las encargadas de transformar las ondas acústicas mecánicas en señales electroquímicas que se dirigen al área auditiva de la corteza cerebral. Estas células ubicadas en el órgano de Corti (OC) no tienen capacidad regenerativa, por lo que al verse sever...

  5. Dental Anxiety in Chilean Adults Who Attend a Primary Care Health Service

    OpenAIRE

    Ríos-Erazo, Matías; Herrera-Ronda, Andrea; Barahona-Salazar, Pilar; Molina-Muñoz, Yerko; Cadenasso-Salinas, Patricia; Zambrano-Canelo, Verónica; Rojas-Alcayaga, Gonzalo

    2016-01-01

    El objetivo fue identificar el nivel de ansiedad dental en una muestra de adultos chilenos que concurren a un servicio de atención de salud primaria. Se realizó un estudio transversal, obteniendo una muestra de 174 adultos, con edades entre los 20 y 70 años, pertenecientes al área urbana de Santiago de Chile, y que acudían en calidad de acompañantes de niños(as) que asistían a atención dental. Se registraron datos socio-demográficos y fecha de último control dental. Se aplicó la escala de ans...

  6. First lasing of the Dutch Fusion-FEM: 730 kW, 200 GHz

    Energy Technology Data Exchange (ETDEWEB)

    Urbanus, W.H. E-mail: urbanus@rijnh.nl; Bongers, W.A.; Geer, C.A.J. van der; Manintveld, P.; Plomp, J.; Pluygers, J.; Poelman, A.J.; Smeets, P.H.M.; Schueller, F.C.; Verhoeven, A.G.A.; Bratman, V.L.; Denisov, G.G.; Savilov, A.V.; Shmelyov, M.Yu.; Caplan, M.; Varfolomeev, A.A

    1999-06-01

    A high-power electrostatic free-electron maser is operated at various frequencies. An output power of 730 kW at 206 GHz is generated with a 7.2 A, 1.77 MeV electron beam, and 360 kW at 167 GHz is generated with a 7.0 A, 1.61 MeV electron beam. It is shown experimentally and by simulations that, depending on the electron beam energy, the FEM can operate in single-frequency regime. First experiments were done without electron beam energy recovery system, and the pulse length was limited to 12 {mu}s. Nevertheless, many aspects of generation of mm-wave power have been explored, such as the dependency on the electron beam energy and beam current and cavity settings such as the feedback coefficient. The achieved parameters and the FEM dynamics are in good accordance with simulations.

  7. Process and system for treating waste water

    Science.gov (United States)

    Olesen, Douglas E.; Shuckrow, Alan J.

    1978-01-01

    A process of treating raw or primary waste water using a powdered, activated carbon/aerated biological treatment system is disclosed. Effluent turbidities less than 2 JTU (Jackson turbidity units), zero TOC (total organic carbon) and in the range of 10 mg/l COD (chemical oxygen demand) can be obtained. An influent stream of raw or primary waste water is contacted with an acidified, powdered, activated carbon/alum mixture. Lime is then added to the slurry to raise the pH to about 7.0. A polyelectrolyte flocculant is added to the slurry followed by a flocculation period -- then sedimentation and filtration. The separated solids (sludge) are aerated in a stabilization sludge basin and a portion thereof recycled to an aerated contact basin for mixing with the influent waste water stream prior to or after contact of the influent stream with the powdered, activated carbon/alum mixture.

  8. FELIX

    International Nuclear Information System (INIS)

    van Amersfoort, P.W.; Best, R.W.B.; van der Geer, C.A.J.; Mastop, W.J.; Meddens, B.J.H.; van der Meer, A.F.G.; Oepts, D.; van der Wiel, M.J.

    1988-01-01

    In this paper the authors review the status of the Dutch free electron laser for infrared experiments (FELIX), with which radiation in the range between 3 μm and 3 mm will be generated. Among their research objectives are rapid tunability and mode reduction by means of an intracavity etalon. The first stage of the project deals with generation of radiation with a wavelength between 8 and 80 μm. The design of the accelerator, with which 70-A, 3ps bunches are accelerated to a maximum energy of 45 MeV, is discussed. It consists of a triode, a 4-MeV buncher, and a travelling-wave linac

  9. The electron accelerator for FELIX [Free Electron Laser for Infrared eXperiments

    International Nuclear Information System (INIS)

    Amersfoort, P.W. van; Geer, C.A.J. van der; Meer, A.F.G. van der; Bruinsma, P.J.T.; Hoekstra, R.; Kroes, F.B.; Luyckx, G.; Noomen, J.G.; Poole, M.W.; Saxon, G.

    1989-01-01

    The authors discuss the design of the electron accelerator for the Free Electron Laser for Infrared eXperiments (FELIX), which is meant to provide the Dutch science community with a rapidly tunable source of infrared radiation. The first stage of the project will (at least) cover the wavelength range between 8 and 80 μm. The accelerator consists of a triode with a grid modulated at 1 GHz, a 3.8-MeV buncher, and two travelling-wave S-band linac structures, with which 70-A, 3-ps bunches are accelerated to an energy between 15 and 4-5 MeV. The system has been designed to minimize the energy spread in the electron beam. 8 refs., 2 figs., 1 tab

  10. Determination of uranium in biological objects using adsorption

    International Nuclear Information System (INIS)

    Zakharova, Eh.A.; Filichkina, O.G.; Pikula, N.P.; Slepchenko, G.B.

    2002-01-01

    A method of U 6+ (0.0001-0.005 mg/liter) determination in urine using adsorption cathode voltammetry is presented. The signal was measured using supporting 0.01 M KCl + 5 x 10 -5 M oxyquinoline + 1x10 -4 M trilon B at pH 6.8 - 7.0. A stationary mercury film electrode on a silver substrate was restituted mechanically and electrochemically. The interfering matrix effect was eliminated using wet mineralization and calcination of the samples (up to 100 ml) and subsequent isolation of oxyquinolinate complex of uranyl with chloroform. The total error, within which the error falls with the probability p=0.95, is ±33%. A systematic error attributed to partial isolation is eliminated via a correction coefficient equal to 1.3 [ru

  11. Integrated Inverter For Driving Multiple Electric Machines

    Science.gov (United States)

    Su, Gui-Jia [Knoxville, TN; Hsu, John S [Oak Ridge, TN

    2006-04-04

    An electric machine drive (50) has a plurality of inverters (50a, 50b) for controlling respective electric machines (57, 62), which may include a three-phase main traction machine (57) and two-phase accessory machines (62) in a hybrid or electric vehicle. The drive (50) has a common control section (53, 54) for controlling the plurality of inverters (50a, 50b) with only one microelectronic processor (54) for controlling the plurality of inverters (50a, 50b), only one gate driver circuit (53) for controlling conduction of semiconductor switches (S1-S10) in the plurality of inverters (50a, 50b), and also includes a common dc bus (70), a common dc bus filtering capacitor (C1) and a common dc bus voltage sensor (67). The electric machines (57, 62) may be synchronous machines, induction machines, or PM machines and may be operated in a motoring mode or a generating mode.

  12. Emission characteristics of Y1Ba2Cu3O7-δ cathode

    International Nuclear Information System (INIS)

    Korenev, S.A.

    1988-01-01

    The results are presented of experimental investigation of the electron beam in diode with cathode on the base of Y 1 Ba 2 Cu 3 O 7-δ . After corresponding cathode training, the cathode made from Y 1 Ba 2 Cu 3 O 7-δ material may be practicable of stable current electron beam yeild. It is shown experimentally that the voltage of diode of about 100-300 kV there exists an evident possibility of forming the electron beams with the current density of 70 A-380 A/cm 2 . The motion velicity of cathode plasma in the direction of anode for this material of a cathode amounts to (1-3)x 10 6 cm/s

  13. Propagación in vitro y convencional de tres especies de bambú.

    OpenAIRE

    Lárraga Sánchez, Noé

    2011-01-01

    Las condiciones fisiográficas y climáticas de México son apropiadas para la propagación y producción de bambú en todo el país. Sin embargo, su aprovechamiento comercial tiene dificultades porque los métodos comunes de propagación son lentos o poco viables. La propagación por semilla se descarta porque la mayoría de las especies de bambú tienen periodos juveniles de hasta 70 años, su floración es impredecible y su semilla recalcitrante. En cuanto a la propagación vegetativa, no existen suficie...

  14. Diagnóstico precoz del rechazo en el trasplante experimental de páncreas total con duodeno en el perro: citología por punción-aspiración con aguja fina

    OpenAIRE

    Rodríguez Abascal, Moisés

    1993-01-01

    El trasplante de páncreas está indicado fundamentalmente en los pacientes con diabetes mellitus tipo I. En la actualidad las soluciones terapéuticas ofertadas son: regímenes de insulina, bombas de infusión subcutánea de insulina, el páncreas artificial, y el trasplante de páncreas; este último sería la posibilidad que más fisiológicamente regularía el mecanismo de homostasis de la glucosa. Desde que se descubrió la insulina hace ya más de 70 años, ha cambiado poco el tratamiento del enferm...

  15. Visual and microplate detection of aflatoxin B2 based on NaCl-induced aggregation of aptamer-modified gold nanoparticles

    International Nuclear Information System (INIS)

    Luan, Yunxia; Chen, Jiayi; Li, Cheng; Ping, Hua; Ma, Zhihong; Lu, Anxiang; Xie, Gang

    2015-01-01

    We describe a fast and sensitive method for the detection of aflatoxin B2 (AFB2) that is based on the addition of AFB2-sensitive aptamers to a colloidal solution of gold nanoparticles (AuNPs). Subsequent addition of AFB2 and NaCl to the solution causes a color change from wine-red to blue-purple. Best results are obtained at a pH value of 7.0, a 10 mM aptamer concentration, and a 2 M concentration of NaCl. The method has a linear dynamic range that extends from 0.025 to 10 ng∙mL −1 of AFB2, and the detection limit is 25 pg∙mL −1 . The method is simple, fast, highly sensitive, and enables both visual and microplate readout. (author)

  16. El loco Concholepas concholepas (Bruguière, 1789) (Mollusca: Gastropoda: Muricidae) como recurso durante el Holoceno Temprano-Medio en Los Vilos, Chile central

    OpenAIRE

    Báez, Pedro; Arata, Javier; Jackson, Donald

    2004-01-01

    Se estudió la abundancia relativa del loco, Concholepas concholepas, y las causas posibles de su variabilidad en los conchales culturales más antiguos del Holoceno Temprano-Medio del litoral de Los Vilos (31º55'S, 71º32'W). Las muestras se obtuvieron en excavaciones arqueológicas de cinco sitios y se dataron con C14: Punta Purgatorio (LV079: 10.040 ± 70 años antes del presente, a.a.p.), Caleta Ñagué (LV098: 10.120 ± 80 a.a.p.), Dunas de Agua Amarilla (LV166: 6.700 ± 60 a.a.p.), Borde Norte de...

  17. Zully Murillo, cantadora de muchas orillas

    Directory of Open Access Journals (Sweden)

    Alejandro Tobón Restrepo

    2015-11-01

    Full Text Available Zully Murillo, cantadora tradicional del Atrato, compositora y mujer de vanguardia, recrea a través de esta entrevista la cotidianidad de su vida, desde su niñez hasta la edad adulta, en un viaje de la memoria donde es posible leer la cultura del Pacífico colombiano de los últimos70 años. La vida del río, la música de las orillas, los rituales y las fiestas, los romances y alabaos, la educación secundaria, la docencia, la creación e interpretación musical, y la música como eje de su vida son los principales temas que se abordan en este diálogo.

  18. Interface of the transport systems research vehicle monochrome display system to the digital autonomous terminal access communication data bus

    Science.gov (United States)

    Easley, W. C.; Tanguy, J. S.

    1986-01-01

    An upgrade of the transport systems research vehicle (TSRV) experimental flight system retained the original monochrome display system. The original host computer was replaced with a Norden 11/70, a new digital autonomous terminal access communication (DATAC) data bus was installed for data transfer between display system and host, while a new data interface method was required. The new display data interface uses four split phase bipolar (SPBP) serial busses. The DATAC bus uses a shared interface ram (SIR) for intermediate storage of its data transfer. A display interface unit (DIU) was designed and configured to read from and write to the SIR to properly convert the data from parallel to SPBP serial and vice versa. It is found that separation of data for use by each SPBP bus and synchronization of data tranfer throughout the entire experimental flight system are major problems which require solution in DIU design. The techniques used to accomplish these new data interface requirements are described.

  19. Studies on the Parametric Effects of Plasma Arc Welding of 2205 Duplex Stainless Steel

    Science.gov (United States)

    Selva Bharathi, R.; Siva Shanmugam, N.; Murali Kannan, R.; Arungalai Vendan, S.

    2018-03-01

    This research study attempts to create an optimized parametric window by employing Taguchi algorithm for Plasma Arc Welding (PAW) of 2 mm thick 2205 duplex stainless steel. The parameters considered for experimentation and optimization are the welding current, welding speed and pilot arc length respectively. The experimentation involves the parameters variation and subsequently recording the depth of penetration and bead width. Welding current of 60-70 A, welding speed of 250-300 mm/min and pilot arc length of 1-2 mm are the range between which the parameters are varied. Design of experiments is used for the experimental trials. Back propagation neural network, Genetic algorithm and Taguchi techniques are used for predicting the bead width, depth of penetration and validated with experimentally achieved results which were in good agreement. Additionally, micro-structural characterizations are carried out to examine the weld quality. The extrapolation of these optimized parametric values yield enhanced weld strength with cost and time reduction.

  20. Extreme Geomagnetic Storms – 1868–2010

    DEFF Research Database (Denmark)

    Vennerstrøm, Susanne; Lefèvre, L.; Dumbović, M.

    2016-01-01

    presents our investigation of the corresponding solar eventsand their characteristics. The storms were selected based on their intensity in the aa index,which constitutes the longest existing continuous series of geomagnetic activity. They areanalyzed statistically in the context of more well...... occurring in May 1921 and the Quebec storm from March 1989. We identifykey characteristics of the storms by combining several different available data sources, listsof storm sudden commencements (SSCs) signifying occurrence of interplanetary shocks,solar wind in-situ measurements, neutron monitor data...... %), Forbushdecreases (100 %), and energetic solar proton events (70 %). A quantitative comparison ofthese associations relative to less intense storms is also presented. Most notably, we findthat most often the extreme storms are characterized by a complexity that is associated with multiple, often interacting, solar...

  1. Fungal and plant gene expression during the colonization of cacao seedlings by endophytic isolates of four Trichoderma species.

    Science.gov (United States)

    Bailey, B A; Bae, H; Strem, M D; Roberts, D P; Thomas, S E; Crozier, J; Samuels, G J; Choi, Ik-Young; Holmes, K A

    2006-11-01

    Endophytic isolates of Trichoderma species are being considered as biocontrol agents for diseases of Theobroma cacao (cacao). Gene expression was studied during the interaction between cacao seedlings and four endophytic Trichoderma isolates, T. ovalisporum-DIS 70a, T. hamatum-DIS 219b, T. harzianum-DIS 219f, and Trichoderma sp.-DIS 172ai. Isolates DIS 70a, DIS 219b, and DIS 219f were mycoparasitic on the pathogen Moniliophthora roreri, and DIS 172ai produced metabolites that inhibited growth of M. roreri in culture. ESTs (116) responsive to endophytic colonization of cacao were identified using differential display and their expression analyzed using macroarrays. Nineteen cacao ESTs and 17 Trichoderma ESTs were chosen for real-time quantitative PCR analysis. Seven cacao ESTs were induced during colonization by the Trichoderma isolates. These included putative genes for ornithine decarboxylase (P1), GST-like proteins (P4), zinc finger protein (P13), wound-induced protein (P26), EF-calcium-binding protein (P29), carbohydrate oxidase (P59), and an unknown protein (U4). Two plant ESTs, extensin-like protein (P12) and major intrinsic protein (P31), were repressed due to colonization. The plant gene expression profile was dependent on the Trichoderma isolate colonizing the cacao seedling. The fungal ESTs induced in colonized cacao seedlings also varied with the Trichoderma isolate used. The most highly induced fungal ESTs were putative glucosyl hydrolase family 2 (F3), glucosyl hydrolase family 7 (F7), serine protease (F11), and alcohol oxidase (F19). The pattern of altered gene expression suggests a complex system of genetic cross talk occurs between the cacao tree and Trichoderma isolates during the establishment of the endophytic association.

  2. Potential costs of bacterial infection on storage protein gene expression and reproduction in queenless Apis mellifera worker bees on distinct dietary regimes.

    Science.gov (United States)

    Lourenço, Anete Pedro; Martins, Juliana Ramos; Guidugli-Lazzarini, Karina Rosa; Macedo, Liliane Maria Fróes; Bitondi, Márcia Maria Gentile; Simões, Zilá Luz Paulino

    2012-09-01

    Insects are able to combat infection by initiating an efficient immune response that involves synthesizing antimicrobial peptides and a range of other defense molecules. These responses may be costly to the organism, resulting in it exploiting endogenous resources to maintain homeostasis or support defense to the detriment of other physiological needs. We used queenless worker bees on distinct dietary regimes that may alter hemolymph protein storage and ovary activation to investigate the physiological costs of infection with Serratia marcescens. The expression of the genes encoding the storage proteins vitellogenin and hexamerin 70a, the vitellogenin receptor, and vasa (which has a putative role in reproduction), was impaired in the infected bees. This impairment was mainly evident in the bees fed beebread, which caused significantly higher expression of these genes than did royal jelly or syrup, and this was confirmed at the vitellogenin and hexamerin 70a protein levels. Beebread was also the only diet that promoted ovary activation in the queenless bees, but this activation was significantly impaired by the infection. The expression of the genes encoding the storage proteins apolipophorins-I and -III and the lipophorin receptor was not altered by infection regardless the diet provided to the bees. Similarly, the storage of apolipophorin-I in the hemolymph was only slightly impaired by the infection, independently of the supplied diet. Taken together these results indicate that, infection demands a physiological cost from the transcription of specific protein storage-related genes and from the reproductive capacity. Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. Science.gov (United States)

    López, Ana Cristina; Cecchetto, Eugenio; Aguirre, Ana Noemí; Ontiveros, Marina Celeste; Roitter, Claudia Valentina; Garcia, Adelaida Judith; Bernet, Jorgelina; Aguirre, Jorge Alberto

    2018-03-23

    El objetivo del estudio fue describir características clínicas, sociodemográficas y hábitos en adultos con diabetes mellitus y estudiar su asociación con la calidad de vida relacionada con la salud. Se seleccionó una muestra de 311 pacientes del Programa de Diabetes de una obra social universitaria, de la provincia de Córdoba. Se analizaron los datos a como proporciones y los componentes físico y mental del cuestionario SF-36® . El 57,4% alcanzó un nivel de instrucción terciario o universitario. La hipertensión arterial fue el factor de riesgo cardiovascular más prevalente (86,8%), seguida por dislipemia (50,6%) y obesidad (46,5%). El 24,8% tenía complicación macrovascular y el 29% microvascular. En el componente físico (CF) de calidad de vida las mujeres tuvieron una chance 4,2 veces mayor de reportar un valor inferior en relación a los varones. Entre los 50 y los 70 años se triplicó y los mayores de  70 años tuvieron 4 veces peor una puntuación en el CF respecto a los más jóvenes. Las complicaciones macro y microvasculares y los que reportaron menos de 2 hábitos de vida saludables tuvieron el doble de chances de puntuar por debajo del promedio general en el CF. La asociación entre complicaciones y peor calidad de vida es un motivo más para alcanzar un buen control metabólico, optimizar el manejo de factores de riesgo, evitando o retrasando la aparición de complicaciones.

  4. In-vivo optical imaging of hsp70 expression to assess collateral tissue damage associated with infrared laser ablation of skin

    Science.gov (United States)

    Wilmink, Gerald J.; Opalenik, Susan R.; Beckham, Joshua T.; Mackanos, Mark A.; Nanney, Lillian B.; Contag, Christopher H.; Davidson, Jeffrey M.; Jansen, E. Duco

    2013-01-01

    Laser surgical ablation is achieved by selecting laser parameters that remove confined volumes of target tissue and cause minimal collateral damage. Previous studies have measured the effects of wavelength on ablation, but neglected to measure the cellular impact of ablation on cells outside the lethal zone. In this study, we use optical imaging in addition to conventional assessment techniques to evaluate lethal and sublethal collateral damage after ablative surgery with a free-electron laser (FEL). Heat shock protein (HSP) expression is used as a sensitive quantitative marker of sublethal damage in a transgenic mouse strain, with the hsp70 promoter driving luciferase and green fluorescent protein (GFP) expression (hsp70A1-L2G). To examine the wavelength dependence in the mid-IR, laser surgery is conducted on the hsp70A1-L2G mouse using wavelengths targeting water (OH stretch mode, 2.94 μm), protein (amide-II band, 6.45 μm), and both water and protein (amide-I band, 6.10 μm). For all wavelengths tested, the magnitude of hsp70 expression is dose-dependent and maximal 5 to 12 h after surgery. Tissues treated at 6.45 μm have approximately 4× higher hsp70 expression than 6.10 μm. Histology shows that under comparable fluences, tissue injury at the 2.94-μm wavelength was 2× and 3× deeper than 6.45 and 6.10 μm, respectively. The 6.10-μm wavelength generates the least amount of epidermal hyperplasia. Taken together, this data suggests that the 6.10-μm wavelength is a superior wavelength for laser ablation of skin. PMID:19021444

  5. Effects of dietary cadmium exposure on tissue-specific cadmium accumulation, iron status and expression of iron-handling and stress-inducible genes in rainbow trout: Influence of elevated dietary iron

    International Nuclear Information System (INIS)

    Kwong, Raymond W.M.; Andres, Jose A.; Niyogi, Som

    2011-01-01

    Recent evidences suggest that dietary cadmium (Cd) uptake likely occurs via the dietary iron (Fe) uptake pathway in freshwater fish, at least in part. The present study investigated the interactive effects of dietary Cd and Fe in juvenile rainbow trout (Oncorhynchus mykiss). Fish were treated for four weeks with four different diets: normal Fe, high Fe, normal Fe plus Cd, and high Fe plus Cd. Physiological parameters, tissue-specific Fe and Cd level, plasma Fe status, and tissue-specific mRNA expression of transferrin, metallothioneins (MT-A and MT-B) and heat shock proteins 70 (HSP70a and HSP70b) were analyzed. Exposure to dietary Cd increased Cd burden in the following order: intestine > kidney > stomach > liver > gill > carcass. Interestingly, high dietary Fe reduced Cd accumulation in the stomach and intestine as well as in the wholebody of fish. Dietary Cd increased hepatic transferrin mRNA expression and total Fe binding capacity in the plasma, indicating the effect of Cd on Fe handling in fish. The mRNA expression of MTs and HSP70s was also increased in various tissues following dietary Cd exposure, however the response profile of different MT and HSP70 genes was not consistent among different tissues. In general, MT-A was more responsive to Cd exposure in the intestine and liver, whereas MT-B was more responsive in the kidney. Similarly, HSP70a expression was more sensitive to Cd exposure than HSP70b, particularly in the intestine. Interestingly, high Fe diet suppressed Cd-induced induction of transferrin, MT and HSP70 genes in various tissues. Overall, our study suggests that elevated dietary Fe can reduce Cd accumulation and ameliorate Cd-induced stress responses in freshwater fish.

  6. Effects of dietary cadmium exposure on tissue-specific cadmium accumulation, iron status and expression of iron-handling and stress-inducible genes in rainbow trout: Influence of elevated dietary iron

    Energy Technology Data Exchange (ETDEWEB)

    Kwong, Raymond W.M. [Toxicology Centre, University of Saskatchewan, Saskatoon, SK, S7N 5B3 (Canada); Andres, Jose A. [Department of Biology, University of Saskatchewan, Saskatoon, SK, S7N 5E2 (Canada); Niyogi, Som, E-mail: som.niyogi@usask.ca [Department of Biology, University of Saskatchewan, Saskatoon, SK, S7N 5E2 (Canada)

    2011-03-15

    Recent evidences suggest that dietary cadmium (Cd) uptake likely occurs via the dietary iron (Fe) uptake pathway in freshwater fish, at least in part. The present study investigated the interactive effects of dietary Cd and Fe in juvenile rainbow trout (Oncorhynchus mykiss). Fish were treated for four weeks with four different diets: normal Fe, high Fe, normal Fe plus Cd, and high Fe plus Cd. Physiological parameters, tissue-specific Fe and Cd level, plasma Fe status, and tissue-specific mRNA expression of transferrin, metallothioneins (MT-A and MT-B) and heat shock proteins 70 (HSP70a and HSP70b) were analyzed. Exposure to dietary Cd increased Cd burden in the following order: intestine > kidney > stomach > liver > gill > carcass. Interestingly, high dietary Fe reduced Cd accumulation in the stomach and intestine as well as in the wholebody of fish. Dietary Cd increased hepatic transferrin mRNA expression and total Fe binding capacity in the plasma, indicating the effect of Cd on Fe handling in fish. The mRNA expression of MTs and HSP70s was also increased in various tissues following dietary Cd exposure, however the response profile of different MT and HSP70 genes was not consistent among different tissues. In general, MT-A was more responsive to Cd exposure in the intestine and liver, whereas MT-B was more responsive in the kidney. Similarly, HSP70a expression was more sensitive to Cd exposure than HSP70b, particularly in the intestine. Interestingly, high Fe diet suppressed Cd-induced induction of transferrin, MT and HSP70 genes in various tissues. Overall, our study suggests that elevated dietary Fe can reduce Cd accumulation and ameliorate Cd-induced stress responses in freshwater fish.

  7. Efectos a corto plazo de la contaminación atmosférica sobre la mortalidad: resultados del proyecto EMECAM en Valencia, 1994-96

    Directory of Open Access Journals (Sweden)

    Tenías Burillo José María

    1999-01-01

    Full Text Available FUNDAMENTO: Estimar el efecto a corto plazo de la contaminación atmosférica sobre la mortalidad en la ciudad de Valencia, durante el periodo 1994-1996, utilizando la metodología de análisis del estudio multicéntrico español sobre la relación entre la contaminación atmosférica y la mortalidad (proyecto EMECAM. MÉTODOS: De la red de vigilancia de la contaminación atmosférica de Valencia se obtuvieron los niveles diarios de humos negros, dióxido de azufre (SO2, dióxido de nitrógeno (NO2, monóxido de carbono (CO y ozono (O3. Los indicadores de mortalidad analizados fueron el número diario de defunciones por todas las causas, menos las externas, la mortalidad en mayores de 70 años, y la ocurrida por enfermedades respiratorias y del aparato circulatorio. Siguiendo la metodología del proyecto EMECAM se construyeron modelos de regresión autoregresiva de Poisson controlando por los diferentes factores de confusión (estacionalidad, tendencia, calendario, variables meteorológicas e incidencia de gripe. RESULTADOS: Para la mortalidad por todas las causas menos las externas se halló un efecto significativo de los humos negros (RR 10 µg/m3: 1,013; IC95% 1,003 a 1,023 y del CO 24 h (RR 1 mg/m3: 1,024; IC95% 1,003 a 1,046. Para la mortalidad en mayores de 70 años el efecto estimado fue algo mayor para humos negros (RR 10 µg/m3: 1,017; IC95% 1,005 - 1,029, así como para SO2 1h (RR 10µg/m3: 1,010; IC95% 1,002 - 1,018 y NO2 1h (RR 10 µg/m3: 1,007; IC95% 1,001 - 1,013. No se encontró una asociación significativa con la mortalidad por enfermedades respiratorias y del aparato circulatorio para todo el período. CONCLUSIONES: Los niveles actuales de contaminación en la ciudad de Valencia presentan un efecto significativo sobre la mortalidad diaria. Estos resultados son consistentes con los de investigaciones anteriores y coherentes con los obtenidos al analizar la relación entre contaminación atmosférica e indicadores de morbilidad.

  8. Yield and composition of pirarucu fillet in different weight classes = Rendimento e composição do filé de pirarucu em diferentes classes de peso

    Directory of Open Access Journals (Sweden)

    Fabíola Helena dos Santos Fogaça

    2011-01-01

    Full Text Available The fillet yield and quantity of waste generated after processing areimportant for planning and evaluating the growth performance of species and systems of aquaculture production in Brazil. The pirarucu (Arapaima gigas is among the species with desirable characteristics for intensive fish with high market value. The objective was to evaluate the performance of pirarucu fillet in different weight classes: 7.0 to 9.0 kg (group I, 11.0 to 13.0 kg (group II and 14.0 to 17.0 kg (group III. The fillet yield presented no significant difference between groups. The composition showed significantdifferences (p O rendimento de filé e a quantidade de resíduos gerada após o processamento são importantes para o planejamento e a avaliação do desempenho zootécnico de espécies e dos sistemas de produção aquícola brasileiros. O pirarucu (Arapaima gigas está entre as espécies com características desejáveis para piscicultura intensiva e com alto valor de mercado. O objetivo do trabalho foi avaliar o rendimento do filé de pirarucu em diferentes classes de peso: 7,0 a 9,0 kg (grupo I, 11,0 a 13,0 kg (grupo II e 14,0 a 17,0 kg (grupo III. O rendimento de filé não apresentou diferença significativa entre os grupos avaliados. A composição apresentou diferenças significativas (p < 0,05 para umidade (77,96 a 75,04% e cinzas (2,21 a 2,46%, enquanto os valores de lipídeos e proteína bruta foram similares entreas classes avaliadas. Na avaliação da porcentagem de lipídios por porção (lombo, barriga e cauda houve maior deposição de gordura na parte ventral e no grupo III. Dessa forma, pode-se abater o pirarucu com média de peso entre 7,0 a 9,0 kg, utilizando-se ciclos de produção mais curtos e obtendo-se filés com melhor qualidade por apresentarem menor porcentagem muscular de lipídio.

  9. Mortalidad atribuible al consumo de tabaco en México

    Directory of Open Access Journals (Sweden)

    Kuri-Morales Pablo

    2002-01-01

    Full Text Available Objetivo. Estudiar la asociación entre defunciones registradas en la delegación Coyoacán y consumo de tabaco y alcohol. Material y métodos. Estudio de mortalidad proporcional y determinación de fracción atribuible en una cohorte de sujetos de la ciudad de México, D.F., México. Se reunió información de todas las defunciones de 1998 captadas a través del Sistema Estadístico y Epidemiológico de las Defunciones (SEED en la delegación Coyoacán, clasificándolas por diagnóstico en enfermedades del sistema circulatorio (ESC, sistema respiratorio (EPOC, neoplasias (NEO. Se encuestó a familiares de los fallecidos sobre consumo de tabaco y alcohol. Resultados. Fumar los últimos 10 años de vida fue significativo para ESC en hombres de 70 años y más (RM: 2.06, IC 95%=1.18-3.58; y continuar fumando el último año de vida fue significativo para NEO y para EPOC en mujeres de 70 años y más (NEO= RM: 7.24, IC 95%=1.71-30.53; ESR= RM: 4.82, IC 95%=1.41-16.50. En el modelo de regresión para ESC, las personas con tabaquismo intenso tuvieron una posibilidad 0.83 veces mayor de fallecer por ESC, y el RA de esta variable para las ESC en la población general fue 45%. (RM=1.83; IC 95% = 1.1-2.8 p<0.01. Conclusiones. La exposición a tabaco es responsible de la elevada incidencia y mortalidad de enfermedades del sistema circulatorio y respiratorio, así como de neoplasias, en una muestra poblacional de sujetos de la ciudad de México.

  10. Comportamiento del carcinoma basocelular facial en Artemisa durante la última década

    Directory of Open Access Journals (Sweden)

    Mileydis Viñas García

    2011-06-01

    Full Text Available El carcinoma basocelular representa aproximadamente entre un 70 a un 80 % de los cánceres cutáneos no melanoma, en la población de color de piel blanca y su tasa de incidencia ha incrementado un 20 % en las últimas 2 décadas. Se realizó un estudio observacional de tipo descriptivo y de corte transversal desde enero de 2000 a diciembre de 2009, para determinar el comportamiento del carcinoma basocelular en los pacientes anotados en el registro de solicitud de biopsias del Servicio de Cirugía Máxilofacial del municipio Artemisa. El universo fueron 1 287 individuos y constituyeron la muestra 607 pacientes con diagnóstico clínico e histopatológico de carcinoma basocelular. Se registraron las siguientes variables: grupo de edad, sexo, color de la piel, ocupación, localización del tumor, formas clínicas de presentación y tipo histopatológico. Se confeccionó un formulario y los datos se procesaron estadísticamente por cálculo porcentual. Los resultados se presentaron en tablas. Se obtuvo un 47,1 % con diagnóstico de carcinoma basocelular en ambos sexos, con ligero predominio en el género masculino, los campesinos y constructores resultaron ser los más afectados. La población de piel blanca constituyó el 98,8 % de los pacientes con carcinoma basocelular y el grupo de edad más afectado fue el de 70 años en adelante. La principal región fue la nasal, la forma clínica de presentación nodular perlada fue la más frecuente. Predominó el tipo histopatológico sólido y tres cuartas partes de los pacientes fueron tratados con exéresis simple. Se concluyó que el carcinoma basocelular constituyó la entidad de mayor prevalencia al afectar casi la mitad de la población objeto de estudio.

  11. Obesidade na criança e no adolescente: quantas calorias a mais são responsáveis pelo excedente de peso?

    Directory of Open Access Journals (Sweden)

    Helen Rose C. Pereira

    2013-06-01

    Full Text Available OBJETIVO: Revisar os principais artigos referentes ao tema desequilíbrio energético e obesidade, a fim de quantificar o excedente energético diário associado ao ganho de peso em crianças e adolescentes. FONTES DE DADOS: Artigos publicados nos últimos dez anos, indexados nas bases de dados eletrônicas Medline (Pubmed e SciELO-Br. Na base de dados Medline, utilizou-se o descritor "energy gap", termo que descreve os valores energéticos associados às modificações no peso corporal em indivíduos ou populações. Na base de dados SciELO-Br, utilizaram-se os descritores "obesidade", "metabolismo energético", "balanço energético" e "desequilíbrio energético", devido ao fato de não terem sido encontrados artigos nacionais que discutissem o assunto "energy gap". SÍNTESE DOS DADOS: Na população infantil, quatro estudos foram realizados e indicam que crianças e adolescentes estão gradualmente ganhando peso devido a um pequeno, mas persistente, balanço energético positivo diário, 70 a 160kcal acima do total calórico adequado para o crescimento. Os valores encontrados sugerem que pequenas modificações nos hábitos diários de alimentação e de atividade física seriam suficientes para evitar futuros ganhos de peso nessa população. CONCLUSÕES: O ganho gradual de peso pode ser explicado por pequena média diária de balanço energético positivo, de 70 a 160kcal acima do total calórico adequado para o crescimento. O incentivo às pequenas modificações nos hábitos alimentares e de atividades físicas que promovam a redução de 160kcal diárias pode ser uma prática acessível, a fim de barrar o ganho de peso nessa população.

  12. Ku-mediated coupling of DNA cleavage and repair during programmed genome rearrangements in the ciliate Paramecium tetraurelia.

    Directory of Open Access Journals (Sweden)

    Antoine Marmignon

    2014-08-01

    Full Text Available During somatic differentiation, physiological DNA double-strand breaks (DSB can drive programmed genome rearrangements (PGR, during which DSB repair pathways are mobilized to safeguard genome integrity. Because of their unique nuclear dimorphism, ciliates are powerful unicellular eukaryotic models to study the mechanisms involved in PGR. At each sexual cycle, the germline nucleus is transmitted to the progeny, but the somatic nucleus, essential for gene expression, is destroyed and a new somatic nucleus differentiates from a copy of the germline nucleus. In Paramecium tetraurelia, the development of the somatic nucleus involves massive PGR, including the precise elimination of at least 45,000 germline sequences (Internal Eliminated Sequences, IES. IES excision proceeds through a cut-and-close mechanism: a domesticated transposase, PiggyMac, is essential for DNA cleavage, and DSB repair at excision sites involves the Ligase IV, a specific component of the non-homologous end-joining (NHEJ pathway. At the genome-wide level, a huge number of programmed DSBs must be repaired during this process to allow the assembly of functional somatic chromosomes. To understand how DNA cleavage and DSB repair are coordinated during PGR, we have focused on Ku, the earliest actor of NHEJ-mediated repair. Two Ku70 and three Ku80 paralogs are encoded in the genome of P. tetraurelia: Ku70a and Ku80c are produced during sexual processes and localize specifically in the developing new somatic nucleus. Using RNA interference, we show that the development-specific Ku70/Ku80c heterodimer is essential for the recovery of a functional somatic nucleus. Strikingly, at the molecular level, PiggyMac-dependent DNA cleavage is abolished at IES boundaries in cells depleted for Ku80c, resulting in IES retention in the somatic genome. PiggyMac and Ku70a/Ku80c co-purify as a complex when overproduced in a heterologous system. We conclude that Ku has been integrated in the Paramecium

  13. Pérdida del precondicionamiento isquémico: un fenómeno relacionado con el envejecimiento

    Directory of Open Access Journals (Sweden)

    Jorge A. Belardi

    2007-01-01

    Full Text Available IntroducciónLa edad es un predictor independiente de riesgo en pacientes con enfermedad coronaria.Esto podría explicarse por la falta de adaptación a la isquemia miocárdica aguda. Elprecondicionamiento es un mecanismo por el cual episodios repetitivos de isquemia inducenen el miocardio una tolerancia mayor a episodios subsiguientes.ObjetivoEvaluar el desarrollo de precondicionamiento isquémico en pacientes añosos.Material y métodosSe incluyeron 65 pacientes sometidos a angioplastia coronaria electiva (< 70 años [n = 47] y≥ 70 años [n = 18]. Se evaluó el desarrollo de precondicionamiento durante tres períodos deoclusión coronaria. Por ECG intracoronario se midió la elevación del ST al final de cada dilatacióny se registró el porcentaje de resolución del ST a la tercera dilatación respecto del máximovalor registrado. Los datos se presentan como mediana e intervalo intercuartil 25/75%.ResultadosNo hubo diferencias significativas en las características clínicas basales. El máximo ST registrado,el ST a la tercera dilatación y el porcentaje de resolución del ST fueron 14 (9/24mm, 8 (4/14 mm y 23,8% (0/55,5 para los pacientes jóvenes y 9,5 (5/18 mm (p = ns, 6,5 (4/16 mm (p = ns y 5,5% (0/20 (p = 0,04 para los añosos. Al estratificar por grupos etarios,la proporción de pacientes que alcanzaron una resolución del ST ≥ 50% mostró una distribuciónlineal por chi cuadrado de tendencia (p = 0,025.ConclusionesNuestro estudio sugiere que el precondicionamiento isquémico se encontraría disminuidoen pacientes añosos. La funcionalidad de este mecanismo menguaría en forma progresivacon el envejecimiento.

  14. Percepción del estudiante de medicina de una universidad pública acerca del docente adulto mayor y del adulto mayor en general

    Directory of Open Access Journals (Sweden)

    Martha Martina

    2014-07-01

    Full Text Available Introducción: La mayoría de los estudios disponibles muestran que las imágenes que construyen los jóvenes sobre la vejez, en general, se asocian a una valoración negativa de esta etapa de la vida. Objetivos: Analizar la percepción de los estudiantes de Medicina Humana de la UNMSM acerca de la vejez, así como la existencia o no de estereotipos negativos acerca de la vejez y del docente adulto mayor. Diseño: Estudio transversal. Institución: Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. Participantes: Estudiantes del primero, tercero y quinto año de la Escuela Académico Profesional de Medicina Humana. Intervenciones: Aplicación de una escala de diferencial semántico para medir la percepción de los estudiantes mediante un cuestionario autoadministrado. Principales medidas de resultados: De una muestra de 319 estudiantes, 54,2% fue del sexo masculino y el promedio de edad 21,7±2,6 años; 90,3% tuvo cercanía con profesores mayores de 70 años. Los alumnos del quinto año otorgaron menores puntuaciones a los docentes adultos mayores (p=0,003 y a los adultos mayores en general (p=0,045. Los estudiantes que en su familia convivían con personas mayores de 70 años tuvieron una percepción más positiva sobre los adultos mayores en general (p=0,037. Respecto a la percepción de los estudiantes acerca del docente adulto mayor destacaron cinco características que superaron el 70% del puntaje, tipificándolo como seguro de sí mismo (78%, organizado (73,9%, interesado en el aprendizaje del estudiante (72,8%, planificador (72,6% y emocionalmente estable (71,8%. Respecto al adulto mayor, los puntajes no superaron el 70%, y en general lo tipificaron como tratable, sociable y hábil. Conclusiones: Los estudiantes de medicina mostraron una percepción positiva hacia el docente adulto mayor y sobre el adulto mayor en general. Existieron diferencias estadísticamente significativas según el año de estudios. Los

  15. Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation.

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    Eunhee Kim

    2017-07-01

    Full Text Available The unfolded protein response (UPR in the endoplasmic reticulum (ER and the cytoplasmic heat stress response are two major stress response systems necessary for maintaining proteostasis for cellular health. Failure of either of these systems, such as in sustained UPR activation or in insufficient heat shock response activation, can lead to the development of neurodegeneration. Alleviation of ER stress and enhancement of heat shock response through heat shock factor 1 (HSF1 activation have previously been considered as attractive potential therapeutic targets for Alzheimer's disease (AD-a prevalent and devastating tauopathy. Understanding the interplay of the two aforementioned systems and their cooperative role in AD remain elusive. Here we report studies in human brain and tau pathogenic mouse models (rTg4510, PS19, and rTg21221, identifying HSF1 degradation and UPR activation as precursors of aberrant tau pathogenesis. We demonstrate that chemical ER stress inducers caused autophagy-lysosomal HSF1 degradation, resulting in tau hyperphosphorylation in rat primary neurons. In addition, permanent HSF1 loss reversely causes chronic UPR activation, leading to aberrant tau phosphorylation and aggregation in the hippocampus of aged HSF1 heterozygous knock-out mice. The deleterious interplay of UPR activation and HSF1 loss is exacerbated in N2a cells stably overexpressing a pro-aggregation mutant TauRD ΔK280 (N2a-TauRD ΔK280. We provide evidence of how these two stress response systems are intrinsically interweaved by showing that the gene encoding C/EBP-homologous protein (CHOP activation in the UPR apoptotic pathway facilitates HSF1 degradation, which likely further contributes to prolonged UPR via ER chaperone HSP70 a5 (BiP/GRP78 suppression. Upregulating HSF1 relieves the tau toxicity in N2a-TauRD ΔK280 by reducing CHOP and increasing HSP70 a5 (BiP/GRP78. Our work reveals how the bidirectional crosstalk between the two stress response systems

  16. Estudio comparativo de la autonomía funcional de adultos mayores: atletas y sedentarios, en altitud moderada

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    Cesar Giovanni Quintero-Burgos

    2017-01-01

    Full Text Available La práctica sistemática de actividad física contribuye al mejoramiento de las condiciones de vida y salud y retarda el proceso de envejecimiento del adulto mayor. Objetivo. Identificar diferencias en la autonomía funcional en hombres de 60 a 70 años, practicantes de ciclismo y sedentarios, residentes en Tunja, a altitud moderada. Materiales y Métodos. Estudio comparativo de corte transversal analítico. Participaron 22 adultos mayores, de sexo masculino; 11 sedentarios y 11 practicantes de ciclo montañismo, con edades entre 60 y 70 años (media 63.03±4.32 años previo consentimiento informado se sometieron a evaluación cineantropomé- trica por bioimpedancia, las pruebas de la batería Senior Fitness Test (SFT de Rikli y Jones (1999a el Test de Ästrand submaximal y dinamometría manual derecha e izquierda. Resultados: Los grupos se encontraron comparables en edad, peso, talla e índice de masa corporal (p>0,05. Se registraron diferencias estadísticamente significativas a favor del grupo de ciclo montañistas, en la media del porcentaje de grasa corporal, densidad ósea, masa muscular, mientras que ni el índice de masa corporal (25,6 ±3,3 y 25,2±2,5 registraron diferencias significativas. En la prueba SFT se encontraron diferencias estadísticamente significativas en la flexión de cadera (p<0,001. En la prueba submaximal se encontraron diferencias estadísticamente significativas en la prueba de esfuerzo en Watts (p=0,021. En la dinamometría de la mano izquierda también se encontraron diferencias estadísticamente significativas (p=0,0007. Conclusión. Los adultos mayores que adelantan rutinariamente prácticas de ejercicio físico como el ciclo montañismo presentan mejores características de composición corporal, flexibilidad de la cintura, mejor capacidad aeróbica y motricidad.

  17. In-situ observation of oxidation of Ti(0001) surface by real-time photoelectron spectroscopy using synchrotron radiation

    CERN Document Server

    Takakuwa, Y; Yoshigoe, A; Teraoka, Y; Mizuno, Y; Tonda, H; Homma, T

    2003-01-01

    Temperature dependence of the initial oxidation kinetics of Ti(0001) surface was investigated by low energy electron diffraction (LEED) and real-time photoelectron spectroscopy using synchrotron radiation of surface- and bulk-sensitive photon energies. LEED observation revealed that oxide layers grow epitaxially with different surface structures depending on temperature: 1x1 at 200degC and sq root 3 x sq root 3 at 400degC. From the oxygen uptake curve measured by O 1s photo-electron intensity, it was clarified that oxygen diffusion through the epitaxially grown oxide layer is significantly enhanced with raising temperature, making the oxide layer thicker than 70A at 400degC. The chemical shift components observed for Ti 2p showed that TiO sub 2 becomes predominant at the subsurface with O sub 2 dose, while the stoichiometry of oxide near the interface is maintained as TiO and Ti sub 2 O sub 3 , for both cases at 200degC and 400degC. Thus it is concluded that the epitaxial growth of a very thin oxide on the Ti...

  18. Printshop open days

    CERN Multimedia

    Anaïs Schaeffer

    2013-01-01

    With new machines, new services and new opening hours, the CERN Printshop has turned over many new leaves at the start of 2013. Come and find out more from 25 to 27 March at the Printshop open days!   The CERN Printshop’s new 8-metre long black and white printer. The CERN Printshop’s new 8-metre long black-and-white printer is a technical marvel. It can produce 160 pages per minute (it prints on both sides in one pass) and can also staple, punch holes, do thermal binding and make A4 or A5 brochures. The new colour printer is more discreet but no less efficient: it churns out 70 A4 or A3 pages per minute. Once they are printed, colour documents can be inserted into the black and white machine to be hole-punched, made into brochures or bound. They can even be mixed in with black-and-white pages and, as if by magic, come out in the right order! Having recently acquired a state-of-the-art large-format printer, the CERN Printshop can now print posters in A2, A1 or A0 format. ...

  19. Differential expression of isoproterenol-induced salivary polypeptides in two mouse strains that are congenic for the H-2 histocompatibility gene complex.

    Science.gov (United States)

    López Solís, Remigio O; Weis, Ulrike Kemmerling; Ceballos, Alicia Ramos; Salas, Gustavo Hoecker

    2003-12-01

    Two inbred mouse strains, A/Snell and A.Swiss, which were produced as congenic with regard to the H-2 histocompatibility gene complex, are homozygous for two different groups of isoproterenol-induced salivary polypeptides (IISP). These polypeptides, which have been considered as markers of the hypertrophic growth of the parotid acinar cells, are members of the complex family of salivary proline-rich proteins (PRP) on the basis of both their massive accumulation in the parotid acinar cells in response to chronic isoproterenol, secretory character, high solubility in trichloroacetic acid and metachromatic staining by Coomassie blue. IISP expressed in both mouse strains were identified by unidimensional SDS-polyacrylamide electrophoresis and Coomassie blue staining both in parotid gland homogenates and in whole salivas obtained from mice repeatedly stimulated at 24-h intervals with isoproterenol. Parotid glands from 40 mice (20 A/Snell and 20 A.Swiss) and salivas from 270 mice (200 A/Snell and 70 A.Swiss) were analyzed. One of the congenic strains (A/Snell) expressed five IISP (Mr 65, 61, 51.5, 38, and 37 kDa) and the other strain (A.Swiss) expressed six IISP (Mr 59, 57, 54.5, 46, 36, and 34 kDa). No inter-individual intra-strain variations were observed, thus defining strain-associated patterns of IISP (PRP). Copyright 2003 Wiley-Liss, Inc.

  20. VELA Network Evaluation and Automatic Processing Research

    Science.gov (United States)

    1974-12-09

    LO/LR COMMFNT NO. (DEGRRES) T=20SFr T=30SRr T^aospr PATTO 937 *>*>. 3 5.20 a. 30 3.^7 7.97 0.0 10 ? 91R 27.9 a.oo 0.0 0.0 0.0 0.0 20 2 qiq 70.a a...FVF^T OISTANCE HB MS US IS LQ/I.P roMMFN7" NO. (DEORF^) T=20SFC T=30SFC T-aosRc PATTO MO 50. 1 5.20 a.oi 3.8 8 1.51 1. 10 10 r, Ml 5a.a 5.00 a...DFORPP^) T=20^KC T=30SEC 7= (4 0^ FC PATTO � lift. 1 s.on «.6 0 «.29 3. 9 9 0.0 in 7 u-\\-i 73.2 i.r-o 0.0 0.0 0.0 0.0 30 7 n in 96.0 1.70 0.0

  1. Distrofia de la membrana basal epitelial

    Directory of Open Access Journals (Sweden)

    Zaadia Pérez Parra

    Full Text Available La distrofia de Cogan es la distrofia corneal anterior más común, frecuente en adultos del sexo femenino, entre 40-70 años de edad. Presentamos un caso de una paciente de 50 años de edad, del sexo femenino, quien refiere visión borrosa, lagrimeo y fotofobia. Al examen de la córnea en lámpara de hendidura se observan imágenes de color grisáceo en forma de huellas dactilares y de mapa. Esta afección es causada por alteraciones de la membrana basal epitelial que provoca la separación parcial o total del epitelio corneal. Generalmente asintomática, es la causa más frecuente de erosión corneal recurrente. Las opciones terapéuticas varían desde lubricantes, soluciones hipertónicas tópicas, lentes de contacto de vendaje, desbridamiento del epitelio central, micropunciones mecánicas o diatermia y fotoqueratectomía con láser excímer.

  2. Energy potential and greenhouse gas emissions from bioenergy cropping systems on marginally productive cropland.

    Directory of Open Access Journals (Sweden)

    Marty R Schmer

    Full Text Available Low-carbon biofuel sources are being developed and evaluated in the United States and Europe to partially offset petroleum transport fuels. Current and potential biofuel production systems were evaluated from a long-term continuous no-tillage corn (Zea mays L. and switchgrass (Panicum virgatum L. field trial under differing harvest strategies and nitrogen (N fertilizer intensities to determine overall environmental sustainability. Corn and switchgrass grown for bioenergy resulted in near-term net greenhouse gas (GHG reductions of -29 to -396 grams of CO2 equivalent emissions per megajoule of ethanol per year as a result of direct soil carbon sequestration and from the adoption of integrated biofuel conversion pathways. Management practices in switchgrass and corn resulted in large variation in petroleum offset potential. Switchgrass, using best management practices produced 3919±117 liters of ethanol per hectare and had 74±2.2 gigajoules of petroleum offsets per hectare which was similar to intensified corn systems (grain and 50% residue harvest under optimal N rates. Co-locating and integrating cellulosic biorefineries with existing dry mill corn grain ethanol facilities improved net energy yields (GJ ha-1 of corn grain ethanol by >70%. A multi-feedstock, landscape approach coupled with an integrated biorefinery would be a viable option to meet growing renewable transportation fuel demands while improving the energy efficiency of first generation biofuels.

  3. Teorias do neo-imperialismo: raízes da teoria marxista do capitalismo mundial The neo-imperialism theories: the roots for the marxist theory of the world capitalism

    Directory of Open Access Journals (Sweden)

    Alex Fiuza de Mello

    2007-05-01

    Full Text Available O texto faz uma incursão em várias interpretações elaboradas a partir dos anos 60-70 a respeito dos dilemas - ainda sem solução - que emanam das mudanças substanciais que o mundo vem sofrendo nos campos da economia, da política e da cultura no final do século passado e início deste. A questão essencial é a seguinte: ainda vivemos o estágio histórico do imperialismo ou a humanidade já ingressa numa outra etapa do processo de desenvolvimento do capitalismo, qualitativamente distinta da precedente? Palavras-chave: Neo-liberalismo. Imperialismo. Marxismo. Globalização. Nacionalismo. This text present various interpretations from the 60's and 70's of the dilemas - still waiting for a solution - that arise from the substancial changes the world underwent in the economy, politics and culture at the end of the 20th century. The essential question is: are we still living under the historical imperialistic period or has humanity entered another period of the process of capital development, qualitatively different from its predecessor? Keywords: Neo-liberalism. Imperialism. Marxism. Globalization. Nationalism.

  4. Psicologias sociais cientificista e crítica: um debate que continua

    Directory of Open Access Journals (Sweden)

    Mariana Prioli Cordeiro

    Full Text Available Diversos autores falam de ao menos duas versões da Psicologia social: uma anterior e outra posterior à crise de referência que assolou essa área do conhecimento na década de 70. A primeira tinha uma base positivista, já a segunda se caracterizava por defender uma ciência comprometida com a transformação social. Em geral, esses textos narram a história da Psicologia social destacando personagens, acontecimentos e ideários. Neste artigo, seguindo a proposta da teoria ator-rede, acrescentamos novos elementos a essa história e falamos dos atores humanos e não humanos, das materialidades e socialidades, que contribuíram para construir a Psicologia social brasileira. Concluímos o texto argumentando que a crise de referência não eliminou por completo a Psicologia social positivista, substituiu-a por uma vertente crítica, pois, ainda hoje, ambas coexistem. Argumentamos, portanto, que a Psicologia social brasileira é complexa, e que essa complexidade não cabe na tênue linha do tempo que muitas vezes traçamos para representar o desenvolvimento de disciplinas acadêmicas.

  5. Development and Validation of a Standardized Tool for Prioritization of Information Sources.

    Science.gov (United States)

    Akwar, Holy; Kloeze, Harold; Mukhi, Shamir

    2016-01-01

    To validate the utility and effectiveness of a standardized tool for prioritization of information sources for early detection of diseases. The tool was developed with input from diverse public health experts garnered through survey. Ten raters used the tool to evaluate ten information sources and reliability among raters was computed. The Proc mixed procedure with random effect statement and SAS Macros were used to compute multiple raters' Fleiss Kappa agreement and Kendall's Coefficient of Concordance. Ten disparate information sources evaluated obtained the following composite scores: ProMed 91%; WAHID 90%; Eurosurv 87%; MediSys 85%; SciDaily 84%; EurekAl 83%; CSHB 78%; GermTrax 75%; Google 74%; and CBC 70%. A Fleiss Kappa agreement of 50.7% was obtained for ten information sources and 72.5% for a sub-set of five sources rated, which is substantial agreement validating the utility and effectiveness of the tool. This study validated the utility and effectiveness of a standardized criteria tool developed to prioritize information sources. The new tool was used to identify five information sources suited for use by the KIWI system in the CEZD-IIR project to improve surveillance of infectious diseases. The tool can be generalized to situations when prioritization of numerous information sources is necessary.

  6. Measuring Critical Care Providers' Attitudes About Controlled Donation After Circulatory Death.

    Science.gov (United States)

    Rodrigue, James R; Luskin, Richard; Nelson, Helen; Glazier, Alexandra; Henderson, Galen V; Delmonico, Francis L

    2018-06-01

    Unfavorable attitudes and insufficient knowledge about donation after cardiac death among critical care providers can have important consequences for the appropriate identification of potential donors, consistent implementation of donation after cardiac death policies, and relative strength of support for this type of donation. The lack of reliable and valid assessment measures has hampered research to capture providers' attitudes. Design and Research Aims: Using stakeholder engagement and an iterative process, we developed a questionnaire to measure attitudes of donation after cardiac death in critical care providers (n = 112) and examined its psychometric properties. Exploratory factor analysis, internal consistency, and validity analyses were conducted to examine the measure. A 34-item questionnaire consisting of 4 factors (Personal Comfort, Process Satisfaction, Family Comfort, and System Trust) provided the most parsimonious fit. Internal consistency was acceptable for each of the subscales and the total questionnaire (Cronbach α > .70). A strong association between more favorable attitudes overall and knowledge ( r = .43, P donation after cardiac death ( P donation after cardiac death.

  7. Cdc45-induced loading of human RPA onto single-stranded DNA.

    Science.gov (United States)

    Szambowska, Anna; Tessmer, Ingrid; Prus, Piotr; Schlott, Bernhard; Pospiech, Helmut; Grosse, Frank

    2017-04-07

    Cell division cycle protein 45 (Cdc45) is an essential component of the eukaryotic replicative DNA helicase. We found that human Cdc45 forms a complex with the single-stranded DNA (ssDNA) binding protein RPA. Moreover, it actively loads RPA onto nascent ssDNA. Pull-down assays and surface plasmon resonance studies revealed that Cdc45-bound RPA complexed with ssDNA in the 8-10 nucleotide binding mode, but dissociated when RPA covered a 30-mer. Real-time analysis of RPA-ssDNA binding demonstrated that Cdc45 catalytically loaded RPA onto ssDNA. This placement reaction required physical contacts of Cdc45 with the RPA70A subdomain. Our results imply that Cdc45 controlled stabilization of the 8-nt RPA binding mode, the subsequent RPA transition into 30-mer mode and facilitated an ordered binding to ssDNA. We propose that a Cdc45-mediated loading guarantees a seamless deposition of RPA on newly emerging ssDNA at the nascent replication fork. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  8. Biodegradation and detoxification of chlorimuron-ethyl by Enterobacter ludwigii sp. CE-1.

    Science.gov (United States)

    Pan, Xiong; Wang, Saige; Shi, Nan; Fang, Hua; Yu, Yunlong

    2018-04-15

    The application of the herbicide chlorimuron-ethyl has a lasting toxic effect on some succession crops. Here, a bacterium capable of utilizing chlorimuron-ethyl as the sole source of nitrogen was isolated from the contaminated soil and was identified as Enterobacter ludwigii sp. CE-1, and its detoxification and degradation of the herbicide were then examined. The biodegradation of chlorimuron-ethyl by the isolate CE-1 was significantly accelerated with increasing concentration (1-10mg/l) and temperature (20-40°C). The optimal pH for the degradation of chlorimuron-ethyl by the isolate CE-1 was pH 7.0. A pathway for the biodegradation of chlorimuron-ethyl by the isolate CE-1 was proposed, in which it could be first converted into 2-amino-4-chloro-6-methoxypyrimidine and an intermediate product by the cleavage of the sulfonylurea bridge and then transformed into saccharin via hydrolysis and amidation. The plant height and fresh weight of corn that had been incubated in nutrient solution containing 0.2mg/l of chlorimuron-ethyl significantly recovered to 83.9% and 83.1% compared with those in the uninoculated control, although the root growth inhibition of chlorimuron-ethyl could not be alleviated after inoculation for 14 d. The results indicate that the isolate CE-1 is a promising bacterial resource for the biodegradation and detoxification of chlorimuron-ethyl. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. [Evaluation of the Charing Cross Venous Ulcer Questionnaire in patients with chronic venous ulcers in Uruguay].

    Science.gov (United States)

    Tafernaberry, Gabriela; Otero, Gabriela; Agorio, Caroline; Dapueto, Juan J

    2016-01-01

    Chronic venous ulcers (CVU) represent a frequent condition, with difficult therapeutic approaches, that impact on patients’ quality of life, and generate an economic burden to patients and health systems. To perform the cultural adaptation and initial evaluation of the Charing Cross Venous Ulcer Questionnaire (CCVUQ) for Uruguay, and to study the health-related quality of life (HRQL) of patients with CVU. The translated and culturally adapted version of the CCVUQ was applied to a convenience sample of 50 patients. In addition, the PROMIS Global Health Survey was included in the assessment. Both questionnaires showed good internal consistency (Cronbach alfa > 0.70). A statistically significant association was observed between the CCVUQ total scores, its subscales and both dimensions of the PROMIS: Global Physical (GPH) and Global Mental Health (GMH) (rho ≥ 0.40). The CCVUQ mean score was 54.9 ± 42 points while GPH and GMH mean scores were 37.9 ± 29 points, and 43.1 ± 35.1 points respectively. Simple linear regression showed that patients with higher income reported better emotional well-being, while in younger patients, ulcers had a higher impact on Emotional Status and Cosmetics. The translated and adapted version of the CCVUQ was easy to comprehend and apply, showing good psychometric properties. When used in association with the PROMIS Global Health Measure it provides complementary information. HRQL was severely affected in the study sample.

  10. Uptake of /sup 86/Rb/sup +/ into photoautotrophic mesophyll cells of Papaver somniferum

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, W.M.; Jeschke, W.D.; Hartung, W.

    1982-06-01

    Uptake of /sup 86/Rb/sup +/, used as a tracer for potassium, into isolated photoautotrophic mesophyll cells of Papaver somniferum was weakly but consistently stimulated in the light. It showed mono-phasic saturation kinetics with a pH optimum of 7.0, a Vsub(max) of 6.7 ..mu..mol mg/sup -1/ Chl x h/sup -1/ and a Ksub(m) of 2.7 mmol l/sup -1/. Different anions as Cl/sup -/, NO/sub 3//sup -/ and PO/sub 4//sup 3 -/ had no effects on /sup 86/Rb/sup +/ uptake. Sodium ions influenced Rb/sup +/-uptake very weakly, indicating a high K/sup +/ -specificity of the mesophyll cell plasmalemma. Fusicoccin stimulated /sup 86/Rb/sup +/ -uptake strongly whereas abscisic acid inhibited uptake only following preincubation for two hours. Nitrite, CCCP and Dio-9 inhibited /sup 86/Rb/sup +/-uptake which gives evidence that this process is dependent on intact pH-gradients within the cells and on ATP-formation.

  11. Saúde como ausência de doença: crítica à teoria funcionalista de Christopher Boorse

    Directory of Open Access Journals (Sweden)

    Almeida Filho Naomar de

    2002-01-01

    Full Text Available Este ensaio é uma introdução à obra de Cristopher Boorse, filósofo da medicina que criou, nos anos 70, a Teoria Bioestatística da Saúde (TBS. Em primeiro lugar, examinamos o argumento e a estrutura da TBS, destacando seus elementos epistemológicos fundamentais e principalmente as justificativas lógicas e teóricas de sua definição da saúde como ausência de doença. Em segundo lugar, discutimos as numerosas críticas recebidas por Boorse em duas décadas de circulação dos seus textos, buscando estabelecer a pertinência e atualidade dessas críticas. Em seguida, identificamos problemas e pontos fortes da teoria boorseana, retomando as principais críticas dirigidas ao autor, bem como suas tentativas de resposta. Por fim, levantamos algumas questões que podem propiciar uma continuidade e um enriquecimento do debate em torno do conceito de saúde a fim de explorar sua aplicabilidade para uma teoria geral da saúde-doença-cuidado, cada vez mais necessária neste momento em que se pretende uma maior articulação entre abordagens biológicas e ecossociais dos fenômenos da saúde e da doença.

  12. Experimental ion mobility measurements in Xe-C2H6

    Science.gov (United States)

    Perdigoto, J. M. C.; Cortez, A. F. V.; Veenhof, R.; Neves, P. N. B.; Santos, F. P.; Borges, F. I. G. M.; Conde, C. A. N.

    2017-10-01

    In this paper we present the results of the ion mobility measurements made in gaseous mixtures of xenon (Xe) with ethane (C2H6) for pressures ranging from 6 to 10 Torr (8-10.6 mbar) and for low reduced electric fields in the 10 Td to 25 Td range (2.4-6.1 kVṡcm-1ṡ bar-1), at room temperature. The time of arrival spectra revealed two peaks throughout the entire range studied which were attributed to ion species with 3-carbons (C3H5+, C3H6+ C3H8+ and C3H9+) and with 4-carbons (C4H7+, C4H9+ and C4H10+). Besides these, and for Xe concentrations above 70%, a bump starts to appear at the right side of the main peak for reduced electric fields higher than 20 Td, which was attributed to the resonant charge transfer of C2H6+ to C2H6 that affects the mobility of its ion products (C3H8+ and C3H9+). The time of arrival spectra for Xe concentrations of 20%, 50%, 70% and 90% are presented, together with the reduced mobilities as a function of the Xe concentration calculated from the peaks observed for the low reduced electric fields and pressures studied.

  13. Development of intense pulsed heavy ion beam diode using gas puff plasma gun as ion source

    International Nuclear Information System (INIS)

    Ito, H.; Higashiyama, M.; Takata, S.; Kitamura, I.; Masugata, K.

    2006-01-01

    A magnetically insulated ion diode with an active ion source of a gas puff plasma gun has been developed in order to generate a high-intensity pulsed heavy ion beam for the implantation process of semiconductors and the surface modification of materials. The nitrogen plasma produced by the plasma gun is injected into the acceleration gap of the diode with the external magnetic field system. The ion diode is operated at diode voltage approx. =200 kV, diode current approx. =2 kA and pulse duration approx. =150 ns. A new acceleration gap configuration for focusing ion beam has been designed in order to enhance the ion current density. The experimental results show that the ion current density is enhanced by a factor of 2 and the ion beam has the ion current density of 27 A/cm 2 . In addition, the coaxial type Marx generator with voltage 200 kV and current 15 kA has been developed and installed in the focus type ion diode. The ion beam of ion current density approx. =54 A/cm 2 is obtained. To produce metallic ion beams, an ion source by aluminum wire discharge has been developed and the aluminum plasma of ion current density ∼70 A/cm 2 is measured. (author)

  14. Manual semen collection from a Grevy's zebra stallion (Equus grevyi), onset of sperm production, semen characteristics, and cryopreservation of semen, with a comparison to the sperm production from a Grant's Zebra stallion (Equus burchelli boehmi).

    Science.gov (United States)

    Crump, J P; Crump, J W

    1994-01-01

    A manual technique was used to collect representative ejaculates from an unrestrained Grevy's zebra stallion beginning at 13 mo of age to determine the onset of sperm production, to calculate the number of spermatozoa produced per ejaculate, and to determine any seasonality associated with sperm production. Spermatozoa first appeared in the ejaculate at 31 mo of age. By 48 mo of age the zebra was producing up to 40 billion spermatozoa per ejaculate. Progressive sperm motility ranged from 75 to 95%. Gel-free semen volume averaged 75 to 120 ml/ejaculate. Gel volume ranged from 0 to 1100 ml/ejaculate. Semen was frozen in 2 different extenders in 0.5-ml PVC straws. The post-thaw motility of cryopreserved spermatozoa ranged from 30 to 70%. A domestic horse mare became pregnant on the first cycle after insemination with frozen-thawed spermatozoa from this zebra. Sperm production data obtained from semen collections made on a Grant's Zebra stallion from 3 to 8 yr of age is presented for comparison of the 2 species.

  15. Electron beam diodes using ferroelectric cathodes

    International Nuclear Information System (INIS)

    Ivers, J.D.; Schaechter, L.; Nation, J.A.; Kerslick, G.S.

    1993-01-01

    A new high current density electron source is investigated. The source consists of a polarized ceramic disk with aluminum electrodes coated on both faces. The front electrode is etched in a periodic grid to expose the ceramic beneath. A rapid change in the polarization state of the ceramic results in the emission of a high density electron cloud into a 1 to 10mm diode gap. The anode potential is maintained by a charged transmission line. Some of the emitted electrons traverse the gap and an electron current flows. The emitted electron current has been measured as a function of the gap spacing and the anode potential. Current densities in excess of 70 A/cm 2 have been measured. The current is found to vary linearly with the anode voltage for gaps < 10 mm, and exceeds the Child-Langmuir current by at least two orders of magnitude. The experimental data will be compared with predictions from a model based on the emission of a cloud of electrons from the ferroelectric which in turn reflex in the diode gap

  16. High-power direct diode laser output by spectral beam combining

    Science.gov (United States)

    Tan, Hao; Meng, Huicheng; Ruan, Xu; Du, Weichuan; Wang, Zhao

    2018-03-01

    We demonstrate a spectral beam combining scheme based on multiple mini-bar stacks, which have more diode laser combining elements, to increase the combined diode laser power and realize equal beam quality in both the fast and slow axes. A spectral beam combining diode laser output of 1130 W is achieved with an operating current of 75 A. When a 9.6 X de-magnifying telescope is introduced between the output mirror and the diffraction grating, to restrain cross-talk among diode laser emitters, a 710 W spectral beam combining diode laser output is achieved at the operating current of 70 A, and the beam quality on the fast and slow axes of the combined beam is about 7.5 mm mrad and 7.3 mm mrad respectively. The power reduction is caused by the existence of a couple resonator between the rear facet of the diode laser and the fast axis collimation lens, and it should be eliminated by using diode laser chips with higher front facet transmission efficiency and a fast axis collimation lens with lower residual reflectivity.

  17. Drastic nickel ion removal from aqueous solution by curcumin-capped Ag nanoparticles

    Science.gov (United States)

    Bettini, S.; Pagano, R.; Valli, L.; Giancane, G.

    2014-08-01

    A completely green synthesis protocol has been adopted to obtain silver nanoaggregates capped by the natural compound (1E, 6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-diene), also known as curcumin. The synthesis has been monitored by infrared, Raman, visible and fluorescence spectroscopies. Characterization confirms that curcumin reduces and caps the nanoparticles, and such a procedure allows its solubility in water and drastically increases curcumin stability. Silver nanoparticles (AgNPs)/curcumin complex has been dispersed in a water solution containing a known nickel ion concentration. After three days, a grey precipitate is observed and nickel concentration in the solution is reduced by about 70%.A completely green synthesis protocol has been adopted to obtain silver nanoaggregates capped by the natural compound (1E, 6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-diene), also known as curcumin. The synthesis has been monitored by infrared, Raman, visible and fluorescence spectroscopies. Characterization confirms that curcumin reduces and caps the nanoparticles, and such a procedure allows its solubility in water and drastically increases curcumin stability. Silver nanoparticles (AgNPs)/curcumin complex has been dispersed in a water solution containing a known nickel ion concentration. After three days, a grey precipitate is observed and nickel concentration in the solution is reduced by about 70%. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr02583k

  18. COMUNIDADES DE APRENDIZAJE EN CONTEXTOS NO FORMALES. LA EXPERIENCIA DE UN TALLER DE TEJIDO

    Directory of Open Access Journals (Sweden)

    Rocío Belén Martín

    2011-01-01

    Full Text Available El propósito de este artículo es describir y analizar los rasgos que propician la creación de una comunidad potencial para el aprendizaje en un contexto no formal; en este caso, el estudio se realiza en un taller de tejido. Participaron aproximadamente 11 mujeres, con edades entre los 25 y los 70 años, quienes asistieron durante el año 2010 a un taller de tejido que se desarrolló en una Asociación Vecinal dependiente de la Municipalidad de la ciudad de Río Cuarto, Argentina. Los datos fueron recabados a través de observaciones de clases, entrevistas a los participantes y a la profesora del curso. Los resultados de la investigación muestran que en este contexto no formal se fomenta el despliegue de algunas dimensiones propias de las comunidades de aprendizaje, como: la retroalimentación, la autonomía, las metas compartidas, la identidad, problemas genuinos y la construcción colaborativa del conocimiento. Los resultados hallados refuerzan las tendencias actuales en el campo de la Psicología Educacional, sobre el valor del contexto de aprendizaje, es decir, en el modo en que las personas crean contextos a través de la relación que se establece entre la persona y los componentes de una actividad.

  19. Ku70 inhibits gemcitabine-induced DNA damage and pancreatic cancer cell apoptosis

    International Nuclear Information System (INIS)

    Ma, Jiali; Hui, Pingping; Meng, Wenying; Wang, Na; Xiang, Shihao

    2017-01-01

    The current study focused on the role of Ku70, a DNA-dependent protein kinase (DNA-PK) complex protein, in pancreatic cancer cell resistance to gemcitabine. In both established cell lines (Mia-PaCa-2 and PANC-1) and primary human pancreatic cancer cells, shRNA/siRNA-mediated knockdown of Ku70 significantly sensitized gemcitabine-induced cell death and proliferation inhibition. Meanwhile, gemcitabine-induced DNA damage and subsequent pancreatic cancer cell apoptosis were also potentiated with Ku70 knockdown. On the other hand, exogenous overexpression of Ku70 in Mia-PaCa-2 cells suppressed gemcitabine-induced DNA damage and subsequent cell apoptosis. In a severe combined immune deficient (SCID) mice Mia-PaCa-2 xenograft model, gemcitabine-induced anti-tumor activity was remarkably pontificated when combined with Ku70 shRNA knockdown in the xenografts. The results of this preclinical study imply that Ku70 might be a primary resistance factor of gemcitabine, and Ku70 silence could significantly chemo-sensitize gemcitabine in pancreatic cancer cells. - Highlights: • Ku70 knockdown sensitizes gemcitabine-induced killing of pancreatic cancer cells. • Ku70 knockdown facilitates gemcitabine-induced DNA damage and cell apoptosis. • Ku70 overexpression deceases gemcitabine's sensitivity in pancreatic cancer cells. • Ku70 knockdown sensitizes gemcitabine-induced anti-tumor activity in vivo.

  20. Novel electroanalysis of hydroxyurea at glassy carbon and gold electrode surfaces

    Directory of Open Access Journals (Sweden)

    Keerti M. Naik

    2014-09-01

    Full Text Available A simple and a novel electroanalysis of hydroxyurea (HU drug at glassy carbon and gold electrode was investigated for the first time using cyclic, linear sweep and differential pulse voltammetric techniques. The oxidation of HU was irreversible and exhibited a diffusion controlled process on both electrodes. The oxidation mechanism was proposed. The dependence of the current on pH, the concentration, nature of buffer, and scan rate was investigated to optimize the experimental conditions for the determination of HU. It was found that the optimum buffer pH was 7.0, a physiological pH. In the range of 0.01 to 1.0 mM, the current measured by differential pulse voltammetry showed a linear relationship with HU concentration with limit of detection of 0.46 µM for glassy carbon electrode and 0.92 µM for gold electrode. In addition, reproducibility, precision and accuracy of the method were checked as well. The developed method was successfully applied to HU determination in pharmaceutical formulation and human biological fluids. The method finds its applications in quality control laboratories and pharmacokinetics.

  1. Estados emocionais de idosas a partir do Teste de Apercepção Temática = Emotional states of elderly women using the Thematic Apperception Test

    Directory of Open Access Journals (Sweden)

    Dallagnol, Claudia

    2014-01-01

    Full Text Available Esta pesquisa teve como objetivo investigar estados emocionais em 10 idosas de 70 a 80 anos, participantes de um grupo de terceira idade. Foi realizado um estudo qualitativo tendo como instrumentos: Teste de Apercepção Temática, Mini Exame do Estado Mental e um questionário sociodemográfico. Foi realizada análise de conteúdo conforme método de Bellak. Como resultado as idosas expressaram necessidades internas de cumprimento do papel materno e emoções que apontaram para o desejo de se manterem ativas, felizes e altruístas, com necessidade de valorização, apoio e ajuda. Revelaram ansiedades vinculadas ao medo de perdas, solidão, dependência, sentimento de incapacidade e preocupação em relação ao futuro. Demonstraram estruturação de ego saudável e superego flexível. Concluiu-se também que o TAT permite a investigação e análise de aspectos emocionais da personalidade em idosas e possibilita uma compreensão psicodinâmica do funcionamento psicológico presente no envelhecimento

  2. High-performance thermoelectric materials based on ternary TiO2/CNT/PANI composites.

    Science.gov (United States)

    Erden, Fuat; Li, Hui; Wang, Xizu; Wang, FuKe; He, Chaobin

    2018-04-04

    In the present work, we report the fabrication of high-performance thermoelectric materials using TiO2/CNT/PANI ternary composites. We showed that a conductivity of ∼2730 S cm-1 can be achieved for the binary CNT (70%)/PANI (30%) composite, which is the highest recorded value for the reported CNT/PANI composites. We further demonstrated that the Seebeck coefficient of CNT/PANI composites could be enhanced by incorporating TiO2 nanoparticles into the binary CNT/PANI composites, which could be attributed to lower carrier density and the energy scattering of low-energy carriers at the interfaces of TiO2/a-CNT and TiO2/PANI. The resulting TiO2/a-CNT/PANI ternary system exhibits a higher Seebeck coefficient and enhanced thermoelectric power. Further optimization of the thermoelectric power was achieved by water treatment and by tuning the processing temperature. A high thermoelectric power factor of 114.5 μW mK-2 was obtained for the ternary composite of 30% TiO2/70% (a-CNT (70%)/PANI (30%)), which is the highest reported value among the reported PANI based ternary composites. The improvement of thermoelectric performance by incorporation of TiO2 suggests a promising approach to enhance power factor of organic thermoelectric materials by judicial tuning of the carrier concentration and electrical conductivity.

  3. Deep Transcriptomic Analysis of Black Rockfish (Sebastes schlegelii) Provides New Insights on Responses to Acute Temperature Stress.

    Science.gov (United States)

    Lyu, Likang; Wen, Haishen; Li, Yun; Li, Jifang; Zhao, Ji; Zhang, Simin; Song, Min; Wang, Xiaojie

    2018-06-14

    In the present study, we conducted an RNA-Seq analysis to characterize the genes and pathways involved in acute thermal and cold stress responses in the liver of black rockfish, a viviparous teleost that has the ability to cope with a wide range of temperature changes. A total of 584 annotated differentially expressed genes (DEGs) were identified in all three comparisons (HT vs NT, HT vs LT and LT vs NT). Based on an enrichment analysis, DEGs with a potential role in stress accommodation were classified into several categories, including protein folding, metabolism, immune response, signal transduction, molecule transport, membrane, and cell proliferation/apoptosis. Considering that thermal stress has a greater effect than cold stress in black rockfish, 24 shared DEGs in the intersection of the HT vs LT and HT vs NT groups were enriched in 2 oxidation-related gene ontology (GO) terms. Nine important heat-stress-reducing pathways were significantly identified and classified into 3 classes: immune and infectious diseases, organismal immune system and endocrine system. Eight DEGs (early growth response protein 1, bile salt export pump, abcb11, hsp70a, rtp3, 1,25-dihydroxyvitamin d(3) 24-hydroxylase, apoa4, transcription factor jun-b-like and an uncharacterized gene) were observed among all three comparisons, strongly implying their potentially important roles in temperature stress responses.

  4. Eversión vesical completa a través de una fístula vesicovaginal

    Directory of Open Access Journals (Sweden)

    Jhoan Aragón Charry

    2013-05-01

    Full Text Available La eversión vesical completa es rara. Se presenta el caso de una eversión de vejiga urinaria a través de una fístula vesicovaginal acompañada de prolapso útero-vaginal concurrente. Se trata de paciente de 70 años que presentó una tumoración compatible con un prolapso vaginal grado IV y una tumoración edematosa, pegajosa y piriforme por delante del prolapso compatible con la vejiga con un orificio en la pared anterior de la vagina a través del cual la mucosa de la vejiga estaba evertida, procediendo al reposicionamiento y corrección manual de la eversión para luego ser corregida quirúrgicamente. Complete bladder eversion through vesicovaginal fistula Abstract Complete bladder eversion is rare. A case of bladder eversion trough vesicovaginal fistula accompanied with concomitant uterovaginal prolapse is presented. A 70 year-old patients presented a tumor compatible with vaginal prolapse type IV and an edematous, sticky and piriform tumor ahead of prolapse compatible with bladder with an orifice on anterior wall of vagina through bladder mucosa was everted, proceeding to reduction and manual correction of eversion and then was surgical corrected.

  5. Sensorimotor and postural control factors associated with driving safety in a community-dwelling older driver population.

    Science.gov (United States)

    Lacherez, Philippe; Wood, Joanne M; Anstey, Kaarin J; Lord, Stephen R

    2014-02-01

    To establish whether sensorimotor function and balance are associated with on-road driving performance in older adults. The performance of 270 community-living adults aged 70-88 years recruited via the electoral roll was measured on a battery of peripheral sensation, strength, flexibility, reaction time, and balance tests and on a standardized measure of on-road driving performance. Forty-seven participants (17.4%) were classified as unsafe based on their driving assessment. Unsafe driving was associated with reduced peripheral sensation, lower limb weakness, reduced neck range of motion, slow reaction time, and poor balance in univariate analyses. Multivariate logistic regression analysis identified poor vibration sensitivity, reduced quadriceps strength, and increased sway on a foam surface with eyes closed as significant and independent risk factors for unsafe driving. These variables classified participants into safe and unsafe drivers with a sensitivity of 74% and specificity of 70%. A number of sensorimotor and balance measures were associated with driver safety and the multivariate model comprising measures of sensation, strength, and balance was highly predictive of unsafe driving in this sample. These findings highlight important determinants of driver safety and may assist in developing efficacious driver safety strategies for older drivers.

  6. Phase transitions, magnetotransport and magnetocaloric effects in a new family of quaternary Ni-Mn-In-Z Heusler alloys.

    Science.gov (United States)

    Kazakov, Alexander; Prudnikov, Valerii; Granovsky, Alexander; Perov, Nikolai; Dubenko, Igor; Pathak, Arjun Kumar; Samanta, Tapas; Stadler, Shane; Ali, Naushad; Zhukov, Arcady; Ilyin, Maxim; Gonzalez, Julian

    2012-09-01

    The magnetic, magnetotransport, and magnetocaloric properties near compound phase transitions in Ni50Mn35In14Z (Z = In, Ge, Al), and Ni48Co2Mn35In15 Heusler alloys have been studied using VSM and SQUID magnetometers (at magnetic fields (H) up to 5 T), four-probe method (at H = 0.005-1.5 T), and an adiabatic magnetocalorimeter (for H changes up to deltaH = 1.8 T), respectively. The martensitic transformation (MT) is accompanied by large magnetoresistance (up to 70%), a significant change in resistivity (up to 200%), and a sign reversal of the ordinary Hall effect coefficient, all related to a strong change in the electronic spectrum at the MT. The field dependences of the Hall resistance are complex in the vicinity of the MT, indicating a change in the relative concentrations of the austenite and martensite phases at strong fields. Negative and positive changes in adiabatic temperatures of about -2 K and +2 K have been observed in the vicinity of MT and Curie temperatures, respectively, for deltaH = 1.8 T.

  7. Implante subcutáneo de un carcinoma hepatocelular tras la punción aspiración con aguja fina Subcutaneous seeding of hepatocellular carcinoma after fine-needle percutaneous biopsy

    Directory of Open Access Journals (Sweden)

    D. Martínez Ramos

    2007-06-01

    Full Text Available Los implantes subcutáneos son una complicación rara tras la punción aspiración con aguja fina de los carcinomas hepatocelulares. Los autores describen un caso de implante subcutáneo neoplásico en una mujer de 70 años con cirrosis hepática por virus C complicada con un carcinoma hepatocelular. Se efectuó una punción aspiración con aguja fina en el segmento II hepático. El implante tumoral se desarrolló en el trayecto de la punción aspiración. La tumoración subcutánea fue extirpada quirúrgicamente y el estudio anatomopatológico confirmó que se trataba de un carcinoma hepatocelular bien diferenciado.Subcutaneous tumor seeding after fine-needle percutaneous biopsy for hepatocellular carcinoma is a rarely seen complication. The authors describe a case of subcutaneous neoplastic seeding in a 70-year-old woman with chronic hepatitis C virus complicated by hepatocellular carcinoma. Ultrasonically guided fine-needle aspiration biopsy was performed in segment II of the liver. The neoplastic seeding developed along the needle track used to carry out the fine-needle biopsy. The subcutaneous tumor was excised, and histological examination revealed a well-differentiated hepatocellular carcinoma.

  8. Evaluation of cardiomyopathy in Duchenne muscular dystrophy by Tl-201 myocardial SPECT

    International Nuclear Information System (INIS)

    Jinnouchi, Seishi; Asai, Junko; Inoue, Kenjirou; Hoshi, Hiroaki; Watanabe, Katsushi.

    1985-01-01

    Clinical evaluation of Tl-201 myocardial SPECT in patients with cardiomyopathy of Duchenne type progressive muscular dystrophy (DMD) was reported. Cases subjected to study were 14 DMD and 8 normal. Using a rotating gamma camera system (ZLC7500 and Scintipac 70A), SPECT data were collected for 16 minutes (32 angles x 30 sec/angle, 180 0 ). The hypoperfusion areas of the left ventricular muscle were observed in 10 patients (71 %), which was in posterior wall (71 %), inferior wall (57 %), lateral and anterior wall (43 %) in the order of frequency. The hypoperfusion area became wider with age and stage, exept for some patients. It was suggested that myocardial degeneration in DMD started in posterior wall and then spread in other areas. For the purpose of quantitative evaluation of myocardial damage, Tl-201 myocardial uptake ratio (MUR) and left ventricular muscle volume (LVMV) were calculated using the results obtained by phantom studies. MUR and LVMV were higher in DMD than those of normal individuals (3.6 +- 1.0 %: 2.7 +- 0.3 %, p < 0.05, 190.2 +- 67.5 ml: 157.8 +- 21.5 ml, n.s., respectively). (author)

  9. Diagnosis and treatment of tuberculous uveitis in a low endemic setting.

    Science.gov (United States)

    Vos, A G; Wassenberg, M W M; de Hoog, J; Oosterheert, J J

    2013-11-01

    To determine factors associated with the diagnosis of tuberculous uveitis and the response to anti-tuberculous treatment (ATT). A retrospective case study was performed at the University Medical Centre Utrecht between October 2007 and December 2009. Patients with possible tuberculous uveitis (TBU) were selected from all patients with an unexplained uveitis. Demographics, ethnicity, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tuberculin skin test (TST), QuantiFERON (QFT) test, and ocular findings were evaluated. An interdisciplinary panel discussed if there was a presumed TBU and decided to start treatment. When there was a decrease in intraocular cell count and/or improvement in visual acuity after ATT, the confirmation of presumed TBU was made. Of 585 patients with unexplained uveitis, 66 (11.3%) fulfilled the definition of possible TBU. Ten (15.4%) patients were regarded as having presumed TBU and received ATT. All of them had latent tuberculosis (LTB). The ocular situation improved in seven patients (70%). A history of TB contact, abnormalities on chest radiology, and extraocular manifestations of TB were associated with a good response to ATT in the case of presumed tuberculous uveitis. Tuberculous uveitis remains difficult to diagnose. No clearly correlating factors that predicted the response to ATT, including ocular parameters, could be identified. Copyright © 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  10. Ascariasis hepática: reporte de un caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Martha Tuñón Pitalua

    2014-01-01

    Full Text Available El absceso hepático causado por áscaris es una presentación muy rara; constituye el 1 % de todos los casos y puede estar compuesto por huevos y/o gusanos adultos. Se presenta caso de mujer de 70 años, admitida por urgencias, con dolor tipo cólico en hemiabdomen superior, vómito, fiebre y sensación de masa; trae reporte de ecografía con colelitiasis, áscaris en el colédoco y aumento del tamaño pancreático. La TAC muestra imagen con aspecto de colección en hígado y parte anterior del páncreas. La biopsia hepática reporta infiltrado inflamatorio crónico mixto de predominio eosinofílico con células gigantes multinucleadas y necrosis, asociado a estructuras circulares compatible con ascariasis. Se realiza tratamiento con antibióticos y antihelmínticos, con evolución satisfactoria. En la literatura consultada son raros los casos reportados de ascariasis hepática, por lo cual es pertinente el reporte del caso.

  11. Properties of nanoparticles prepared from NdFeB-based compound for magnetic hyperthermia application.

    Science.gov (United States)

    Périgo, E A; Silva, S C; de Sousa, E M B; Freitas, A A; Cohen, R; Nagamine, L C C M; Takiishi, H; Landgraf, F J G

    2012-05-04

    Nanoparticles were prepared from a NdFeB-based alloy using the hydrogen decrepitation process together with high-energy ball milling and tested as heating agent for magnetic hyperthermia. In the milling time range evaluated (up to 10 h), the magnetic moment per mass at H = 1.59 MA m(-1) is superior than 70 A m(2) kg(-1); however, the intrinsic coercivity might be inferior than 20 kA m(-1). The material presents both ferromagnetic and superparamagnetic particles constituted by a mixture of phases due to the incomplete disproportionation reaction of Nd(2)Fe(14)BH(x) during milling. Solutions prepared with deionized water and magnetic particles exposed to an AC magnetic field (H(max) ~ 3.7 kA m(-1) and f = 228 kHz) exhibited 26 K ≤ ΔT(max) ≤ 44 K with a maximum estimated specific absorption rate (SAR) of 225 W kg(-1). For the pure magnetic material milled for the longest period of time (10 h), the SAR was estimated as ~2500 W kg(-1). In vitro tests indicated that the powders have acceptable cytotoxicity over a wide range of concentration (0.1-100 µg ml(-1)) due to the coating applied during milling.

  12. Allyl isothiocyanate induced stress response in Caenorhabditis elegans

    Directory of Open Access Journals (Sweden)

    Saini AkalRachna K

    2011-11-01

    Full Text Available Abstract Background Allyl isothiocyanate (AITC from mustard is cytotoxic; however the mechanism of its toxicity is unknown. We examined the effects of AITC on heat shock protein (HSP 70 expression in Caenorhabditis elegans. We also examined factors affecting the production of AITC from its precursor, sinigrin, a glucosinolate, in ground Brassica juncea cv. Vulcan seed as mustard has some potential as a biopesticide. Findings An assay to determine the concentration of AITC in ground mustard seed was improved to allow the measurement of AITC release in the first minutes after exposure of ground mustard seed to water. Using this assay, we determined that temperatures above 67°C decreased sinigrin conversion to AITC in hydrated ground B. juncea seed. A pH near 6.0 was found to be necessary for AITC release. RT-qPCR revealed no significant change in HSP70A mRNA expression at low concentrations of AITC ( 1.0 μM resulted in a four- to five-fold increase in expression. A HSP70 ELISA showed that AITC toxicity in C. elegans was ameliorated by the presence of ground seed from low sinigrin B. juncea cv. Arrid. Conclusions • AITC induced toxicity in C. elegans, as measured by HSP70 expression. • Conditions required for the conversion of sinigrin to AITC in ground B. juncea seed were determined. • The use of C. elegans as a bioassay to test AITC or mustard biopesticide efficacy is discussed.

  13. Comprehensive Review of Preschool Age Anemia in the Pacific Island Jurisdictions.

    Science.gov (United States)

    Lin, Tiffany F; Huang, James N; Cash, Haley L

    2017-12-01

    Anemia can be an indicator of poor nutrition and health, and it can have significant consequences. Children are disproportionately affected by anemia. This comprehensive review summarizes the available literature on anemia prevalence in young children in the islands of the Oceania region. The anemia prevalence, the criteria used for diagnosis, the date the data was reported, and the types of samples collected were reviewed. Anemia prevalence estimates were reported for eighteen of the Pacific Island Jurisdictions. From the fifteen data sources that were evaluable, anemia prevalence ranged from 12.3% to over 70%. A major limitation in the data is a lack of representative primary data from many of the jurisdictions in the region. Prevalance estimates reported for those jurisdictions are estimated by regression analysis from the World Health Organization (WHO). Moreover, the primary data available does not use standardized reporting criteria. Nevertheless, this review serves as a new baseline for further investigations on the prevalence of anemia and a baseline for evaluating public health prevention and treatment measures to detect and improve anemia prevalence in the Pacific.

  14. Avaliação do cuidado prestado a pacientes diabéticos em nível primário

    Directory of Open Access Journals (Sweden)

    Rejane B. Araújo

    1999-02-01

    Full Text Available OBJETIVO: Descrever características de pacientes diabéticos acompanhados em um posto de atenção primária à saúde. MÉTODOS: Estudo transversal. Rastrearam-se 3.024 prontuários de família, em busca de pacientes com 30-75 anos, com diagnóstico de diabetes, atendidos nos últimos cinco anos. Os pacientes detectados foram entrevistados em seus domicílios, e compareceram ao posto para o exame físico e requisição para dosagem da hemoglobina glicosilada. RESULTADOS: A prevalência de diabetes foi de 4,2%. A maioria eram mulheres brancas, ±50 anos de idade, com renda familiar mensal <= 3 salários-mínimos. Menos de um terço seguia dieta; e, apenas um quinto fazia exercícios regulares. Cerca de 70% estavam em uso de hipoglicemiantes orais ou insulina. Dos que fizeram o exame (adesão de 70%, a maioria apresentou níveis normais ou aceitáveis de glicemia. CONCLUSÕES: Maior esforço deve ser dispendido pelas equipes de saúde de forma a promover a adesão dos pacientes diabéticos à dieta e ao exercício.

  15. Enzymic conversion of starch to glucose

    Energy Technology Data Exchange (ETDEWEB)

    1964-08-19

    Corn is steeped in a SO/sub 2/ solution for 30 to 40 hours, coarsely ground, separated from the germ, and filtered. A 35% suspension of the germ-free corn, still containing fibers, hull, and gluten, is treated with Ca(OH)/sub 2/ to raise the pH to 6.5 to 7.0. A starch-liquifying enzyme is added and after a 2 hours treatment at 85/sup 0/ the liquefied starch is cooled to 60/sup 0/ and the pH is adjusted to 4.5 to 5.0 with H/sub 2/SO/sub 4/. A saccharifying enzyme is now added. After 40 to 81 hours, a raw glucose solution is obtained and is freed from fibers and gluten by filtration. The commercial starch-liquifying enzymes are designated HT-1000 and Neozyme 3 LC (liquid). The saccharifying enzymes are Diazyme or Diazyme L 30 (liquid). The solid enzymes are used at a level up to 0.1% by weight of the starch. Up to 100% conversion of starch into glucose is achieved.

  16. Preliminary observation on the effect of baking soda volume on controlling odour from discarded organic waste.

    Science.gov (United States)

    Qamaruz-Zaman, N; Kun, Y; Rosli, R-N

    2015-01-01

    Food wastes with high moisture and organic matter content are likely to emit odours as a result of the decomposition process. The management of odour from decomposing wastes is needed to sustain the interest of residents and local councils in the source separation of kitchen wastes. This study investigated the potential of baking soda (at 50 g, 75 g and 100g per kg food waste) to control odour from seven days stored food waste. It was found that 50 g of baking soda, spread at the bottom of 8l food wastes bin, can reduce the odour by about 70%. A higher amount (above 100g) is not advised as a pH higher than 9.0 may be induced leading to the volatilization of odorous ammonia. This research finding is expected to benefit the waste management sector, food processing industries as well as the local authorities where malodour from waste storage is a pressing issue. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. batman Interacts with polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor.

    Science.gov (United States)

    Faucheux, M; Roignant, J-Y; Netter, S; Charollais, J; Antoniewski, C; Théodore, L

    2003-02-01

    Polycomb and trithorax group genes maintain the appropriate repressed or activated state of homeotic gene expression throughout Drosophila melanogaster development. We have previously identified the batman gene as a Polycomb group candidate since its function is necessary for the repression of Sex combs reduced. However, our present genetic analysis indicates functions of batman in both activation and repression of homeotic genes. The 127-amino-acid Batman protein is almost reduced to a BTB/POZ domain, an evolutionary conserved protein-protein interaction domain found in a large protein family. We show that this domain is involved in the interaction between Batman and the DNA binding GAGA factor encoded by the Trithorax-like gene. The GAGA factor and Batman codistribute on polytene chromosomes, coimmunoprecipitate from nuclear embryonic and larval extracts, and interact in the yeast two-hybrid assay. Batman, together with the GAGA factor, binds to MHS-70, a 70-bp fragment of the bithoraxoid Polycomb response element. This binding, like that of the GAGA factor, requires the presence of d(GA)n sequences. Together, our results suggest that batman belongs to a subset of the Polycomb/trithorax group of genes that includes Trithorax-like, whose products are involved in both activation and repression of homeotic genes.

  18. Nanomolar detection of methylparaben by a cost-effective hemoglobin-based biosensor

    Energy Technology Data Exchange (ETDEWEB)

    Hajian, A., E-mail: ali.hajian@fmf.uni-freiburg.de [Freiburg Materials Research Center, FMF, University of Freiburg, Stefan-Meier-Str.21, 79104 Freiburg (Germany); Laboratory for Sensors, Department of Microsystems Engineering, IMTEK, University of Freiburg, 79110 Freiburg (Germany); Ghodsi, J.; Afraz, A. [Department of Physical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, 65174, Hamedan (Iran, Islamic Republic of); Yurchenko, O. [Freiburg Materials Research Center, FMF, University of Freiburg, Stefan-Meier-Str.21, 79104 Freiburg (Germany); Urban, G. [Freiburg Materials Research Center, FMF, University of Freiburg, Stefan-Meier-Str.21, 79104 Freiburg (Germany); Laboratory for Sensors, Department of Microsystems Engineering, IMTEK, University of Freiburg, 79110 Freiburg (Germany)

    2016-12-01

    This work describes the development of a new biosensor for methylparaben determination using electrocatalytic properties of hemoglobin in the presence of hydrogen peroxide. The voltammetric oxidation of methylparaben by the proposed biosensor in phosphate buffer (pH = 7.0), a physiological pH, was studied and it was confirmed that methylparaben undergoes a one electron-one proton reaction in a diffusion-controlled process. The biosensor was fabricated by carbon paste electrode modified with hemoglobin and multiwalled carbon nanotube. Based on the excellent electrochemical properties of the modified electrode, a sensitive voltammetric method was used for determination of methylparaben within a linear range from 0.1 to 13 μmol L{sup −1} and detection limit of 25 nmol L{sup −1}. The developed biosensor possessed accurate and rapid response to methylparaben and showed good sensitivity, stability, and repeatability. Finally, the applicability of the proposed biosensor was verified by methylparaben evaluation in various real samples. - Highlights: • A new methylparaben biosensor was constructed by modification of carbon paste electrode with hemoglobin and MWCNTs. • The electrochemical properties of the modified electrode and electrochemical behavior of the methylparaben on the electrode surface were studied. • The response of modified GCE was analyzed by voltammetry technique (CV and DPV). • The electrode was used to the determination of methylparaben in real samples • The performance of the fabricated biosensor was satisfactorily compared to the previously reported electrochemical sensors for methylparaben determination.

  19. The OSIRIS diffractometer and polarisation analysis spectrometer at ISIS. New developments and 3He spin-filter polarisation analysis

    International Nuclear Information System (INIS)

    Andersen, Ken H.; Marero, David Martin y; Barlow, Michael J.

    2001-01-01

    OSIRIS combines a long-wavelength powder diffractometer with a polarisation analysis backscattering spectrometer. The diffractometer can access wavelengths up to 70 A with a resolution of better than 1% Δd/d. The very high counting-rate at shorter wavelengths is ideal for in-situ, real-time and parametric experiments. The spectroscopy section incorporates an array of graphite crystals arranged in near-backscattering to give a high counting rate with 25 μeV energy resolution. The incident beam is polarised using a supermirror bender and the scattered beam is polarisation-analysed by a 3 He spin-filter in the process of being constructed. The spin-filter system consists of a fibre laser, a peristaltic pump and a wide-angle banana-shaped quartz cell in a continuous-flow setup. The scattered beam passes twice through the spin-filter cell, thus doubling the optical path length in the cell. The aim is to achieve 70% nuclear polarisation with no variation in time. (author)

  20. The influence of remelting parameters of the electric arc and conventional tempering on the tribological resistance of high speed steel HS 6-5-2

    Directory of Open Access Journals (Sweden)

    A. Dziedzic

    2011-07-01

    Full Text Available The present thesis depicts the results of the research of tribological high speed steel HS 6-5-2 remelted with the electric arc. Steel was remelted with different parameters. The amperage of electric arc was changed, the scanning speed was changed and the single, overlapping remeltings were used. There was also the influence of conventional tempering defined, which was conducted after remelting on the tribological resistance of hardened steel. For the previously mentioned processing variants, the intensity of tribological wear was defined and the linear wear were presented, and the friction coefficients. The type of tribological wear was also given, present during the friction, technically dry, of the hardened steel. The lower intensity of tribological wear was received for the single remelting by electric arc of 50 and 70A. Using the overlapping remeltings for the strengening of the surface layer of the high speed steel HS 6-5-2 causes the increase of the intensity of tribological wear in comparison to the steel with the single remelting. The conventional tempering leads to the decrease of the intensity of tribological wear.

  1. Mineralogical issues in long-term corrosion of iron and iron-nickel alloys

    International Nuclear Information System (INIS)

    VanOrden, A.C.; McNeil, M.B.

    1988-01-01

    Prediction of very long term corrosion behavior of buried objects in general requires taking into account that the corrosion processes themselves after the local conditions. Recent work has analyzed corrosion processes in terms of trajectories on Pourbaix diagrams and appears to offer the prospect for using short-term corrosion tests to project corrosion behavior over very long periods. Two different classes of materials are considered here: essentially pure iron, which is an analogue to the carbon steel design overpacks for the salt and basalt sites (on which work has been suspended at present, and iron-nickel alloys, which are the best analogues available for some of the alloys being considered on the tuff site. There are a number of sources of data on corrosion of iron over archaeological times; the data used in this paper are from the recent National Bureau of Standards work on Roman iron nails for Inchtuthill in Scotland, which can be dated fairly precisely to about 70 A.D. and whose method of production is understood. The only available source of natural-analogue data on Fe-Ni alloys is the corrosion of meteorites

  2. Formation of fouling deposits on a carbon steel surface from Colombian heavy crude oil under preheating conditions

    Science.gov (United States)

    Muñoz Pinto, D. A.; Cuervo Camargo, S. M.; Orozco Parra, M.; Laverde, D.; García Vergara, S.; Blanco Pinzon, C.

    2016-02-01

    Fouling in heat exchangers is produced by the deposition of undesired materials on metal surfaces. As fouling progresses, pressure drop and heat transfer resistance is observed and therefore the overall thermal efficiency of the equipment diminishes. Fouling is mainly caused by the deposition of suspended particles, such as those from chemical reactions, crystallization of certain salts, and some corrosion processes. In order to understand the formation of fouling deposits from Colombian heavy oil (API≈12.3) on carbon steel SA 516 Gr 70, a batch stirred tank reactor was used. The reactor was operated at a constant pressure of 340psi while varying the temperature and reaction times. To evaluate the formation of deposits on the metal surfaces, the steel samples were characterized by gravimetric analysis and Scanning Electron Microscopy (SEM). On the exposed surfaces, the results revealed an increase in the total mass derived from the deposition of salt compounds, iron oxides and alkaline metals. In general, fouling was modulated by both the temperature and the reaction time, but under the experimental conditions, the temperature seems to be the predominant variable that controls and accelerates fouling.

  3. Effect of inhomogeneous Schottky barrier height of SnO2 nanowires device

    Science.gov (United States)

    Amorim, Cleber A.; Bernardo, Eric P.; Leite, Edson R.; Chiquito, Adenilson J.

    2018-05-01

    The current–voltage (I–V) characteristics of metal–semiconductor junction (Au–Ni/SnO2/Au–Ni) Schottky barrier in SnO2 nanowires were investigated over a wide temperature range. By using the Schottky–Mott model, the zero bias barrier height Φ B was estimated from I–V characteristics, and it was found to increase with increasing temperature; on the other hand the ideality factor (n) was found to decrease with increasing temperature. The variation in the Schottky barrier and n was attributed to the spatial inhomogeneity of the Schottky barrier height. The experimental I–V characteristics exhibited a Gaussian distribution having mean barrier heights {\\overline{{{Φ }}}}B of 0.30 eV and standard deviation σ s of 60 meV. Additionally, the Richardson modified constant was obtained to be 70 A cm‑2 K‑2, leading to an effective mass of 0.58m 0. Consequently, the temperature dependence of I–V characteristics of the SnO2 nanowire devices can be successfully explained on the Schottky–Mott theory framework taking into account a Gaussian distribution of barrier heights.

  4. Identification of a residue critical for the excision of 3′-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family

    Science.gov (United States)

    Castillo-Acosta, Víctor M.; Ruiz-Pérez, Luis M.; Yang, Wei; González-Pacanowska, Dolores; Vidal, Antonio E.

    2009-01-01

    DNA single-strand breaks containing 3′-blocking groups are generated from attack of the sugar backbone by reactive oxygen species or after base excision by DNA glycosylase/apurinic/apyrimidinic (AP) lyases. In human cells, APE1 excises sugar fragments that block the 3′-ends thus facilitating DNA repair synthesis. In Leishmania major, the causal agent of leishmaniasis, the APE1 homolog is the class II AP endonuclease LMAP. Expression of LMAP but not of APE1 reverts the hypersensitivity of a xth nfo repair-deficient Escherichia coli strain to the oxidative compound hydrogen peroxide (H2O2). To identify the residues specifically involved in the repair of oxidative DNA damage, we generated random mutations in the ape1 gene and selected those variants that conferred protection against H2O2. Among the resistant clones, we isolated a mutant in the nuclease domain of APE1 (D70A) with an increased capacity to remove 3′-blocking ends in vitro. D70 of APE1 aligns with A138 of LMAP and mutation of the latter to aspartate significantly reduces its 3′-phosphodiesterase activity. Kinetic analysis shows a novel role of residue D70 in the excision rate of 3′-blocking ends. The functional and structural differences between the parasite and human enzymes probably reflect a divergent molecular evolution of their DNA repair responses to oxidative damage. PMID:19181704

  5. A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo

    Directory of Open Access Journals (Sweden)

    Shi-Jie Zhang

    2016-02-01

    Full Text Available Gestational diabetes mellitus (GDM is one of the leading causes of fetal malformations. However, few models have been developed to study the underlying mechanisms of GDM-induced fetal eye malformation. In this study, a high concentration of glucose (0.2 mmol per egg was injected into the air sac of chick embryos on embryo development day (EDD 1 to develop a hyperglycemia model. Results showed that 47.3% of embryonic eye malformation happened on EDD 5. In this model, the key genes regulating eye development, Pax6, Six3 and Otx2, were downregulated by hyperglycemia. Among these genes, the expression of Pax6 was the most vulnerable to hyperglycemia, being suppressed by 70%. A reduction in Pax6 gene expression induced eye malformation in chick embryos. However, increased expression of Pax6 in chick embryos could rescue hyperglycemia-induced eye malformation. Hyperglycemia stimulated O-linked N-acetylglucosaminylation, which caused oxidative stress in chick embryos. Pax6 was found to be vulnerable to free radicals, but the antioxidant edaravone could restore Pax6 expression and reverse eye malformation. These results illustrated a successful establishment of a new chick embryo model to study the molecular mechanism of hyperglycemia-induced eye malformation. The suppression of the Pax6 gene is probably mediated by oxidative stress and could be a crucial target for the therapy of GDM-induced embryonic eye malformation.

  6. KERAGAMAN SERANGGA PADA TANAMAN CABAI (CAPSICUM ANNUUM YANG DIBERI PESTISIDA SINTETIS VERSUS BIOPESTISIDA RACUN LABA-LABA (NEPHILA SP.

    Directory of Open Access Journals (Sweden)

    Yayan Sanjaya

    2013-09-01

    Full Text Available The objective of this research was to compare the diversity of insects in chili plant agroecosystem treated with synthetic pesticide versus that treated with biopesticide (venom of spider Nephila sp. Two plots of chili pepper plants, each sized 600 m2, located at Ciwidey area Bandung –West Java, were taken as the sample plots. The first plot was weekly treated with profenofos insecticide (50% active ingredient, a.i. while the second plot was treated with  biopesticide (70% a.i. spider venom extracted from Nephila sp., each at 35 ml/17 L rate of spray solution. Sweep net was used to sample insects along two transects in each plot. Result showed that 14 families of 8 insect orders were found in pesticide-treated plot while 15 families of  9 orders were found in biopesticide-treated plot. The evenness index and diversity index of insects in plot treated with biopesticide were relatively higher than those in pesticide-treated plot. In contrast, dominance index in biopesticide plot was lower than that in synthetic pesticide plot. Thrips sp.(Thysanoptera: Thripidae was found to be the most dominant species in both plots.

  7. AVALIAÇÃO DA CAPACIDADE FUNCIONAL DE IDOSOS EM UMA COMUNIDADE DO MUNICÍPIO DE MORENO – PE

    Directory of Open Access Journals (Sweden)

    MARIA EMÍLIA VILELA TENÓRIO

    2006-01-01

    Full Text Available El objetivo de este estudio fue evaluar la capacidad funcional de las personas mayores. Es una investigación descriptiva, realizada en la Comunidad Alto das Estrelas, Moreno-PE, con 30 personas mayores registradas en PSF. Para recoger los datos necesarios se usó un formulario constando de tres partes: 1 identificación de la persona mayor, 2 Escala de Actividades de Vida Diaria (AVD y Escala de Actividades Instrumentales de Vida Diaria (AIVD, 3 identificación de las causas de las incapacidades de la persona mayor, aplicado durante la visita domiciliar. Los resultados obtenidos mencionaron: 16 mujeres y 14 hombres; edad entre 60 y 70 años; agricultores casados, jubilados o pensionistas; no alfabetizados; viviendo con hijos y nietos, ayudándoles; realizando actividades de ocio y actividades religiosas. Las quejas principales sobre la salud: la falta de memoria (“el olvido” y las alteraciones visuales. Se descubrieron tres personas mayores que dependían de ayuda, debido a secuela decurrente de Accidente Vascular Cerebral, enfermedad óseo-articular y enfermedad psiquiátrica. Se elaboró una propuesta de rehabilitación y mantenimiento de la capacidad funcional de las personas mayores atendidas en USF.

  8. Body image of Greek breast cancer patients treated with mastectomy or breast conserving surgery.

    Science.gov (United States)

    Anagnostopoulos, Fotios; Myrgianni, Spyridoula

    2009-12-01

    The aim of this study was to assess and compare the body image of breast cancer patients (n = 70) whom underwent breast conserving surgery or mastectomy, as well as to compare patients' scores with that of a sample of healthy control women (n = 70). A secondary objective of this study was to examine the reliability and validity of the 10-item Greek version of the Body Image Scale, a multidimensional measure of body image changes and concerns. Exploratory and confirmatory factor analyses on the items of this scale resulted in a two factor solution, indicating perceived attractiveness, and body and appearance satisfaction. Comparison of the two surgical groups revealed that women treated with mastectomy felt less attractive and more self-conscious, did not like their overall appearance, were dissatisfied with their scar, and avoided contact with people. Hierarchical regression analysis showed that more general body image concerns were associated with belonging to the mastectomy group, compared to the cancer-free group of women. Implications for clinical practice and recommendations for future investigations are discussed.

  9. INTERGENERACIONALIDAD Y ESCUELA: «TRABAJAMOS JUNTOS, APRENDEMOS JUNTOS»

    Directory of Open Access Journals (Sweden)

    Fernando Albuerne

    2002-01-01

    Full Text Available La solidaridad intergeneracional es una recomendación y un objetivo de organismos nacionales e internacionales en relación con el envejecimiento, que frecuentemente implica también a las generaciones más jóvenes de la comunidad. Partiendo de las indicaciones hechas en el Año Internacional de las Personas Mayores, promovido y auspiciado por las Naciones Unidas, se llevó a cabo un programa intergeneracional que se desarrolló en dos villas asturianas de la cuenca minera del Nalón. Participaron 45 mayores de dos Centros de Personas Mayores (media de 70 años y 80 niños de 5º de Primaria de dos Colegios Públicos. Se realizó la captación e información en los Centros y Escuelas, pasándose a los participantes un cuestionario a modo de pretest. Los escenarios de interacción fueron las aulas respectivas y el Centro de Mayores. Los encuentros se articularon en torno a tres oficios («Salas Activas» y tres actividades manuales («Talleres», alternando. Se realizó evaluación continua del proceso constatándose una estimable satisfacción en y con la relación intergeneracional, extensiva a las familias.

  10. Preliminary observation on the effect of baking soda volume on controlling odour from discarded organic waste

    Energy Technology Data Exchange (ETDEWEB)

    Qamaruz-Zaman, N., E-mail: cenastaein@usm.my; Kun, Y.; Rosli, R.-N.

    2015-01-15

    Highlights: • Approximately 50 g baking soda reduced odour concentration by 70%. • Reducing volatile acid concentration reduces odour concentration. • Ammonia has less effect on odour concentration. - Abstract: Food wastes with high moisture and organic matter content are likely to emit odours as a result of the decomposition process. The management of odour from decomposing wastes is needed to sustain the interest of residents and local councils in the source separation of kitchen wastes. This study investigated the potential of baking soda (at 50 g, 75 g and 100 g per kg food waste) to control odour from seven days stored food waste. It was found that 50 g of baking soda, spread at the bottom of 8 l food wastes bin, can reduce the odour by about 70%. A higher amount (above 100 g) is not advised as a pH higher than 9.0 may be induced leading to the volatilization of odorous ammonia. This research finding is expected to benefit the waste management sector, food processing industries as well as the local authorities where malodour from waste storage is a pressing issue.

  11. FACTORES SOCIOECONÓMICOS Y TECNOLÓGICOS EN LA PRODUCCIÓN DE AGROECOSISTEMAS CON CAÑA DE AZÚCAR (Saccharum officinarum L. EN LA CHONTALPA, TABASCO

    Directory of Open Access Journals (Sweden)

    Liliana Armida-Alcudia

    2011-11-01

    Full Text Available La caña de azúcar es una de los cultivos pilares en la economía de Tabasco, México, pues se cultivan 27,041 ha que contribuyen con el 4 % de la producción nacional de azúcar, ocupando el tercer lugar en superficie cultivada. Esta investigación tuvo como objetivo identificar los principales factores que impactan los rendimientos en el agroecosistema cañero del Ingenio Presidente Benito Juárez. Se entrevistaron a 150 productores y se analizó la información con estadística descriptiva. Entre las características socioeconómicas de los productores destacan la edad (51 % entre 50 y 70 años, escolaridad (40 % con estudios de primaria, la escasez de mano de obra familiar, entre otras. En cuanto a las tecnológicas destacan el cultivar MEX 79-431 sembrado en menor área pero con mayor rendimiento, de entre 50 y 60 t ha1; la fertilización comúnmente aplicada es triple 17 por 30 % de los productores y la mezcla 20-10-10 es a pliada por 26 %; 58 % de los productores reportó nulo acceso a asesoría técnica.

  12. cardiovasculares em um grupo de idosos

    Directory of Open Access Journals (Sweden)

    Joselany Afio Caetano

    2008-01-01

    Full Text Available Estudio descriptivo, con abordaje cuantitativo, cuyo objetivo fue investigar los factores de riesgo relacionados con las alteraciones cardiovasculares en ancianos, atendidos en una institución pública de Fortaleza - CE, el año de 2006. Para la recolección de los datos fueron entrevistados 145 ancianos. Los resultados fueron organizados en tablas y analizados en porcentuales descriptivos. Los resultados obtenidos mostraron que un 43,4% de la población se encuentra en la faja etaria por encima de 70 años, predomina el sexo femenino y la renta familiar incide en uno o menos de un salario mínimo. Además de ello, un 52% no son alfabetizados, la mayoría es casada y reside con los familiares, 59,3% de los entrevistados tienen antecedentes de hipertensión y un 41%, son sedentarios. Entre los factores de riesgo citados sobresalen: el consumo de café, sal y grasa. Las afecciones crónico-degenerativas están presentes en la mayoría de los ancianos. Por lo tanto, se considera que es necesario intensificar los programas de educación en salud con el objetivo de mantener el nivel de calidad de vida del anciano.

  13. Onicomicosis: resultados preliminares del tratamiento clinicoquirúrgico en un grupo de pacientes

    Directory of Open Access Journals (Sweden)

    Rubén Pérez Armas

    1995-08-01

    Full Text Available Se hace un estudio de 40 pacientes con onicomicosis tratadas con la técnica quirúrgica seguida de aplicación local de zeolita esterilizada al 100 %, en el Servicio de Dermatología del Hospital Provincial Clinicoquirúrgico "Celia Sánchez Manduley" en el período comprendido entre mayo de 1992 y mayo de 1993. Sólo participaron pacientes con los criterios de inclusión propuestos en el protocolo de investigación. El 30 % correspondió a candidiasis ungueal y el 70 % a tiña ungueal. Se observaron resultados excelentes de curación en el 96,8 %. El tiempo mínimo de curación fue de 3 meses y el máximo de observación de 6 meses. Se subrayan las ventajas de esta técnsica en comparación con otros tratamientos utilizados según reportes de la literatura médica revisada, porque acorta el tiempo de curación y tratamiento, disminuye el costo por paciente curado, se evitaron los efectos secundarios que los medicamentos de nuevo tipo pueden producir, disminuyendo además sus importaciones con el consiguiente ahorro de divisas para el país. Demuestra el efecto polivalente de la zeolita tópica al 100 % sobre los dermatofitos y candidas.

  14. Irritable bowel syndrome and functional abdominal pain in five-year-old children are related to lifestyle.

    Science.gov (United States)

    Uusijärvi, Agneta; Alm, Johan; Lindblad, Frank; Olén, Ola

    2016-08-01

    Abdominal pain of functional origin is very common in childhood, and environmental factors are thought to be of aetiologic importance. The anthroposophic lifestyle has dietary and lifestyle characteristics that may influence child health, and this study aimed to assess the effect of such lifestyles on abdominal pain of functional origin. A prospective Swedish lifestyle cohort (n = 470) was followed from birth to five years of age. Family lifestyles were characterised through questionnaires. Abdominal pain was defined as irritable bowel syndrome or functional abdominal pain according to the Rome III criteria and measured with parental questionnaires and interviews at the age of five. The prevalence of abdominal pain was 15%. Children were more likely to have abdominal pain at five years of age if their family had a partly anthroposophic lifestyle, with an adjusted odds ratio (OR) of 2.61 (95% CI 1.15-5.93), or an anthroposophic lifestyle, with an adjusted OR of 2.34 (95% CI 0.96-5.70). A family lifestyle with anthroposophic characteristics was associated with an increased risk of abdominal pain in five-year-old children. The mechanisms for this increase were unclear, but we speculate that there may have been different prerequisites for coping with stressors. ©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  15. Dependence of the polar Kerr angle and coercivity on repeat distance in sequentially prepared Tb/FeCo films

    International Nuclear Information System (INIS)

    Shin, S.

    1991-01-01

    Multilayer thin films of Tb and FeCo were prepared by sequential thermal evaporation of Tb and Fe 90 Co 10 alloy on glass substrates at ambient temperature in a vacuum of about 1 x 10 -6 Torr. The repeat distance of the films was varied from 3.5 to 175 A while maintaining the composition constant for all samples. Low-angle x-ray diffraction and Auger electron spectroscopy showed that a multilayer structure was achieved for films fabricated with a repeat distance Λ≥31.5 A. The polar Kerr rotation angle and coercivity of the samples were obtained by measuring the polar Kerr hysteresis loop using a 632.8-nm HeNe laser. It was observed that for the samples having a multilayer structure, the remnant Kerr angle and coercivity monotonically decreased with increasing repeat distance, and eventually disappeared for Λ≥70 A. For the samples showing a nonmultilayer structure, the remnant Kerr angle was independent of repeat distance. However, the coercivity increased with repeat distance until a broad maximum was obtained around Λ congruent 14--21 A

  16. DuoPIGatron ion sources for PLT injectors

    International Nuclear Information System (INIS)

    Tsai, C.C.; Stirling, W.L.; Haselton, H.H.; Davis, R.C.; Schechter, D.E.

    1977-01-01

    Plasma heating requirements for the Princeton Large Torus (PLT) are set at about 1 MJ total beam energy for 3 MW beam power of energetic hydrogen (or deuterium) neutrals at 40 keV. To fulfill this design goal from four neutral beam injectors, the duoPlGatron ion source originally developed at ORNL has been modified, developed, and scaled-up to versions with 20-cm and/or 22-cm grid diameters. Utilizing the multipole line cusp magnetic field confinement for the ionizing electrons and created Philips Ionization Gauge (PIG) plasma, these sources generate a uniform (+-5 percent density variation over 23-cm diam) and dense plasma (about 2 x 10 12 cm 3 at the extraction surface). Such sources have been operated reliably to deliver a beam current exceeding 70 A of hydrogen ions at 40 keV. For such a beam condition the source is capable of running with an arc pulse of 0.5 sec. Moreover, the corresponding arc efficiency is very high, below 1.0 KW arc power per ampere of ion beam current. In this paper we describe the plasma generation, source characteristics and arc efficiency as functions of magnetic fields, gas pressure, and arc power (including the arc voltage and current). The other exciting feature, high proton yield (exceeding 80 percent), will be discussed

  17. Clean coal technology

    International Nuclear Information System (INIS)

    Abelson, P.H.

    1990-01-01

    One of the major technology challenges in the next decade will be to develop means of using coal imaginatively as a source of chemicals and in a more energy-efficient manner. The Clean Air Act will help to diminish the acid rain but will not reduce CO 2 emissions. The Department of Energy (DOE) is fostering many innovations that are likely to have a positive effect on coal usage. Of the different innovations in the use of coal fostered by DOE, two are of particular interest. One is the new pressurized fluid bed combustion (PFBC) combined-cycle demonstration. The PFBC plant now becoming operational can reduce SO 2 emissions by more than 90% and NO x emissions by 50-70%. A second new technology co-sponsored by DOE is the Encoal mild coal gasification project that will convert a sub-bituminous low-BTU coal into a useful higher BTU solid while producing significant amounts of a liquid fuel

  18. The diagnostic value of [{sup 18}F]FDG PET for the detection of chronic osteomyelitis and implant-associated infection

    Energy Technology Data Exchange (ETDEWEB)

    Wenter, Vera; Albert, Nathalie L.; Lehner, Sebastian; Fendler, Wolfgang P.; Bartenstein, Peter [University of Munich, Department of Nuclear Medicine, Munich (Germany); Mueller, Jan-Phillip; Friederichs, Jan; Militz, Matthias; Hungerer, Sven [BG Trauma Center Murnau, Murnau (Germany); PMU Salzburg, Salzburg (Austria); Cyran, Clemens C. [University of Munich, Institute for Clinical Radiology, Munich (Germany); Hacker, Marcus [University of Vienna, Department of Nuclear Medicine, Vienna (Austria); Department of Biomedical Imaging and Image-guided Therapy, Vienna (Austria)

    2016-04-15

    The diagnosis of osteomyelitis and implant-associated infections in patients with nonspecific laboratory or radiological findings is often unsatisfactory. We retrospectively evaluated the contributions of [{sup 18}F]FDG PET and [{sup 18}F]FDG PET/CT to the diagnosis of osteomyelitis and implant-associated infections, enabling timely and appropriate decision-making for further therapy options. [{sup 18}F]FDG PET or PET/CT was performed in 215 patients with suspected osteomyelitis or implant-associated infections between 2000 and 2013. We assessed the diagnostic accuracy of both modalities together and separately with reference to intraoperative microbial findings, with a mean clinical follow-up of 69 ± 49 months. Infections were diagnosed clinically in 101 of the 215 patients. PET and PET/CT scans revealed 87 true-positive, 76 true-negative, 38 false-positive, and 14 false-negative results, indicating a sensitivity of 86 %, a specificity of 67 %, a positive predictive value (PPV) of 70 %, a negative predictive value (NPV) of 84 % and an accuracy of 76 %. The sensitivity of PET/CT was 88 %, but specificity, PPV, NPV and accuracy (76 %, 76 %, 89 % and 82 %, respectively) were higher than those of stand-alone PET. [{sup 18}F]FDG PET is able to identify with high sensitivity the presence of osteomyelitis in orthopaedic surgery patients with nonspecific clinical symptoms of infection. (orig.)

  19. 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair

    International Nuclear Information System (INIS)

    Liu, Hongbing; Herrmann, Christine H.; Chiang, Karen; Sung, Tzu-Ling; Moon, Sung-Hwan; Donehower, Lawrence A.; Rice, Andrew P.

    2010-01-01

    Positive elongation factor b (P-TEFb) is a cellular protein kinase that is required for RNA polymerase II (RNAP II) transcriptional elongation of protein coding genes. P-TEFb is a set of different molecular complexes, each containing CDK9 as the catalytic subunit. There are two isoforms of the CDK9 protein - the major 42 KDa CDK9 isoform and the minor 55KDa isoform that is translated from an in-frame mRNA that arises from an upstream transcriptional start site. We found that shRNA depletion of the 55K CDK9 protein in HeLa cells induces apoptosis and double-strand DNA breaks (DSBs). The levels of apoptosis and DSBs induced by the depletion were reduced by expression of a 55K CDK9 protein variant resistant to the shRNA, indicating that these phenotypes are the consequence of depletion of the 55K protein and not off-target effects. We also found that the 55K CDK9 protein, but not the 42K CDK9 protein, specifically associates with Ku70, a protein involved in DSB repair. Our findings suggest that the 55K CDK9 protein may function in repair of DNA through an association with Ku70.

  20. MORTALIDADE POR CÂNCER DE COLO UTERINO, 1996-2011, SANTA CATARINA, BRASIL

    Directory of Open Access Journals (Sweden)

    Kathleen Mary Hegadoren

    2014-01-01

    Full Text Available Estudio cuantitativo de base poplacional. Los autores tienen como objectivo examinar las influencias de la región, la edad y el tiempo en la mortalidad por cáncer de cuello uterino. Las tasas de mortalidad que ocurrieron en el Estado de Santa Catarina, entre 1996 y 2011 fueron analizados. Los datos fueron obtenidos del Sistema de Información de Mortalidad del Ministerio de Salud, Brasil, en el año 2013. El analisis de los datos fue realizada fundamentada en la epidemiologia descritiva. Las tasas de mortalidad por cáncer de cuello uterino variaron desde 3,6 hasta 5,0 / 100.000 mujeres. Estas tasas aumentaron en los grupos de mayor edad y presentaron los valores más altos después de 70 años. La conciencia de la mujer acerca de la importancia del la prueba de Papanicolaou en sus evaluaciones de salud, puede ser diferente según la edad y las regiones en las que viven. La frecuencia de la prueba de Papanicolaou debe cambiar mediante la observación de la evolución de las tasas de mortalidad en el tiempo.

  1. CORS911:Real-Time Subsidence Monitoring of the Napoleonville Salt Dome Sinkhole Using GPS

    Science.gov (United States)

    Kent, J. D.

    2013-12-01

    The sinkhole associated with the Napoleonville salt dome in Assumption Parish, Louisiana, threatens the stability of Highway 70 - a state maintained route. To mitigate the potential damaging effects to the highway and address issues of public safety, a program of research and decision support has been implemented to provide long-term measurements of the surface stability using continuous operating GPS reference stations (CORS). Four CORS sites were installed in the vicinity of the sinkhole to measure the horizontal and vertical motions of each site relative to each other and a fixed location outside the study area. Differential motions measured by a integrity monitoring software are summarized for response agencies tasked with ensuring public safety and stability of the Highway, a designated hurricane evacuation route. Implementation experience and intermediate findings will be shared and discussed. Strategies for monitoring random and systematic biases detected in the system are presented. Figure depicting the location of CORS sites used to monitor surface stability along Highway 70 near the Bayou Corne Sinkhole.

  2. Morphogenic responses of three explants of Lupinus montanus (H.B.K. cultured in vitro

    Directory of Open Access Journals (Sweden)

    Gabriel Ramírez-González

    2015-01-01

    Full Text Available Resumen El necrosamiento y la respuesta morfogénica de explantes de cotiledón, epicótilo e hipocótilo de plántulas de Lupinus montanus (H.B.K. germinadas in vitro se evaluaron para establecer las condiciones básicas de micropropagación. El necrosamiento se evaluó en medio MS con 0.40 mg·litro-1 de tiamina, 100 mg·litro-1 de mioinositol, 3 % de sacarosa y 7 g·litro-1 de agar-agar y distintas dosis de carbón activado (CA y ácido cítrico. Los tratamientos con CA (50 mg·litro-1 y 100 mg·litro-1 fueron los mejores en el control del necrosamiento (P = 0.001; el cotiledón tuvo mayor nivel de necrosamiento ( 70 % a diferencia del cotiledón, cuya respuesta fue primordialmente callogénica (50 %. El epicótilo cultivado en medio MS con 3.0 μM de AIA y 1.0 μM de BA tuvo el mayor número de brotes (10 y altura (11.4 ± 2.6 cm.

  3. Treatment of the baker's yeast wastewater by electrocoagulation

    Energy Technology Data Exchange (ETDEWEB)

    Kobya, M. [Department of Environmental Engineering, Gebze Institute of Technology, 41400 Gebze (Turkey)], E-mail: kobya@gyte.edu.tr; Delipinar, S. [Department of Environmental Engineering, Gebze Institute of Technology, 41400 Gebze (Turkey)

    2008-06-15

    In the laboratory-scale experiments, treatment of baker's yeast production wastewater has been investigated by electrocoagulation (EC) using a batch reactor. Effects of the process variables such as pH, electrode material (Fe and Al), current density, and operating time are investigated in terms of removal efficiencies of chemical oxygen demand (COD), total organic carbon (TOC), turbidity, and operating cost, respectively. The maximum removal efficiencies of COD, TOC and turbidity under optimal operating conditions, i.e., pH 6.5 for Al electrode and pH 7 for Fe electrode, current density of 70 A/m{sup 2} and operating time of 50 min were 71, 53 and 90% for Al electrode and 69, 52 and 56% for Fe electrode, respectively. Al electrode gave 4.4 times higher removal efficiency of turbidity than Fe electrode due to interference from color of dissolved iron. The operating costs for Al and Fe electrodes in terms of $/m{sup 3} or $/kg COD were 1.54 and 0.82, 0.51 and 0.27, respectively.

  4. Treatment of the baker's yeast wastewater by electrocoagulation

    International Nuclear Information System (INIS)

    Kobya, M.; Delipinar, S.

    2008-01-01

    In the laboratory-scale experiments, treatment of baker's yeast production wastewater has been investigated by electrocoagulation (EC) using a batch reactor. Effects of the process variables such as pH, electrode material (Fe and Al), current density, and operating time are investigated in terms of removal efficiencies of chemical oxygen demand (COD), total organic carbon (TOC), turbidity, and operating cost, respectively. The maximum removal efficiencies of COD, TOC and turbidity under optimal operating conditions, i.e., pH 6.5 for Al electrode and pH 7 for Fe electrode, current density of 70 A/m 2 and operating time of 50 min were 71, 53 and 90% for Al electrode and 69, 52 and 56% for Fe electrode, respectively. Al electrode gave 4.4 times higher removal efficiency of turbidity than Fe electrode due to interference from color of dissolved iron. The operating costs for Al and Fe electrodes in terms of $/m 3 or $/kg COD were 1.54 and 0.82, 0.51 and 0.27, respectively

  5. Development of exploding wire ion source for intense pulsed heavy ion beam accelerator

    International Nuclear Information System (INIS)

    Ochiai, Y.; Murata, T.; Ito, H.; Masugata, K.

    2012-01-01

    A Novel exploding wire type ion source device is proposed as a metallic ion source of intense pulsed heavy ion beam (PHIB) accelerator. In the device multiple shot operations is realized without breaking the vacuum. The basic characteristics of the device are evaluated experimentally with an aluminum wire of diameter 0.2 mm, length 25 mm. Capacitor bank of capacitance 3 μF, charging voltage 30 kV was used and the wire was successfully exploded by a discharge current of 15 kA, rise time 5.3 μs. Plasma flux of ion current density around 70 A/cm 2 was obtained at 150 mm downstream from the device. The drift velocity of ions evaluated by a time-of-flight method was 2.7x10 4 m/sec, which corresponds to the kinetic energy of 100 eV for aluminum ions. From the measurement of ion current density distribution ion flow is found to be concentrated to the direction where ion acceleration gap is placed. From the experiment the device is found to be acceptable for applying PHIB accelerator. (author)

  6. Nesting ecology of tundra swans on the coastal Yukon-Kuskokwim Delta, Alaska

    Science.gov (United States)

    Babcock, C.A.; Fowler, A.C.; Ely, Craig R.

    2002-01-01

    Nesting ecology of Tundra Swans (Cygnus columbianus columbianus) was studies the Kashunuk River near Old Chevak (61A?26a??N, 165A?27a??W), on the Yukon-Kuskokwim Delta of western Alaska from 1988-2000. Annual variation in snow-melt chronology, nesting phenology, nesting density, clutch size and nest success was examined. The same area (approximately 23 kmA?) was searched each year and nests were found as early as possible in the laying period. Laying initiation dates ranged from 1-27 May and hatch dates from 12 June a?? 4 July among pairs and years of study. The peak arrival of Tundra Swans and the phenology of nest initiation and hatch were highly correlated with the progression of ice and snow melt in spring. Nest density averaged 0.71 kmA? and 89% of nesting pairs hatched at least one egg. Incubation period ranged from 26 to 33 days with a median of 30 days. Clutch size varied significantly among years, driven by a low mean value of 3.4 eggs in 1999. Clutch sizes were generally larger than found in previous investigations on the Yukon-Kuskokwim Delta, and nearly one egg larger than reported for clutches from Alaskaa??s North Slope (=70A?N). There was no indication of reduced clutch size in years of late spring snow melt, although nesting density tended to be lower.

  7. Predicting ground contact events for a continuum of gait types: An application of targeted machine learning using principal component analysis.

    Science.gov (United States)

    Osis, Sean T; Hettinga, Blayne A; Ferber, Reed

    2016-05-01

    An ongoing challenge in the application of gait analysis to clinical settings is the standardized detection of temporal events, with unobtrusive and cost-effective equipment, for a wide range of gait types. The purpose of the current study was to investigate a targeted machine learning approach for the prediction of timing for foot strike (or initial contact) and toe-off, using only kinematics for walking, forefoot running, and heel-toe running. Data were categorized by gait type and split into a training set (∼30%) and a validation set (∼70%). A principal component analysis was performed, and separate linear models were trained and validated for foot strike and toe-off, using ground reaction force data as a gold-standard for event timing. Results indicate the model predicted both foot strike and toe-off timing to within 20ms of the gold-standard for more than 95% of cases in walking and running gaits. The machine learning approach continues to provide robust timing predictions for clinical use, and may offer a flexible methodology to handle new events and gait types. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Donor Retention in Online Crowdfunding Communities: A Case Study of DonorsChoose.org.

    Science.gov (United States)

    Althoff, Tim; Leskovec, Jure

    2015-05-01

    Online crowdfunding platforms like DonorsChoose.org and Kick-starter allow specific projects to get funded by targeted contributions from a large number of people. Critical for the success of crowdfunding communities is recruitment and continued engagement of donors. With donor attrition rates above 70%, a significant challenge for online crowdfunding platforms as well as traditional offline non-profit organizations is the problem of donor retention. We present a large-scale study of millions of donors and donations on DonorsChoose.org, a crowdfunding platform for education projects. Studying an online crowdfunding platform allows for an unprecedented detailed view of how people direct their donations. We explore various factors impacting donor retention which allows us to identify different groups of donors and quantify their propensity to return for subsequent donations. We find that donors are more likely to return if they had a positive interaction with the receiver of the donation. We also show that this includes appropriate and timely recognition of their support as well as detailed communication of their impact. Finally, we discuss how our findings could inform steps to improve donor retention in crowdfunding communities and non-profit organizations.

  9. Theory of mind and language development in Japanese children with hearing loss.

    Science.gov (United States)

    Fujino, Hiroshi; Fukushima, Kunihiro; Fujiyoshi, Akie

    2017-05-01

    This study investigates the development of theory of mind (ToM) in Japanese children with hearing loss (HL) and its relationship with language abilities using the data of a large sample size. Participants were 369 children with HL, ranging from 4 to 12 years of age. The mean hearing level of the better ear was 100.7 dB. A "change in location"-type false belief task similar to the "Sally-Anne test" was given to the participants. The pass rates for the false belief task were in the 20% range for 4 to 6-year-olds, 35.6% for 7-year-olds, 47.6% for 8-year-olds, and 63.6% for 9-year-olds. However, no children, even 12-year-olds, achieved a pass rate of 70%. A logistic regression analysis showed that the significant independent predictors of the false belief task performance were vocabulary age and syntactic comprehension level, and chronological age, hearing level, syntactic production level, and nonverbal intelligence were excluded. The results demonstrate that there is a delay in the development of ToM in Japanese children with HL. This finding is consistent with findings in English-speaking countries. Additionally, it is suggested that language abilities play an important role in the acquisition of ToM for children with HL. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. The characterization of multilayers analyzers: Models and measurements

    International Nuclear Information System (INIS)

    Henke, B.L.; Vejio, J.Y.; Tackaberry, R.E.; Yamada, H.T.

    1985-01-01

    A procedure is described for the detailed characterization of multilayer analyzers which can be effectively applied to their design, optimization and application for absolute x-ray spectrometry. An accurate analytical model has been developed that is based upon a simple modification of the dynamical Darwin-Prins theory to extend its application to finite multilayer systems. Its equivalence to the optical E and M solution of the Fresnel equations at each interface is demonstrated by detailed calculation comparisons for the reflectivity of a multilayer throughout the angular range of incidence of 0 to 90 0 . A special spectrograph and experimental method is described for the measurement of the absolute reflectivity characteristics of the multilayer. The experimental measurements at three photon energies in the 100-200 eV region are fit by the analytical modified Darwin-Prins equation (MDP) for I(θ), generating a detailed characterization of two ''state of the art'' multilayers, a sputtered tungsten-carbon of 2d ≅ 70 A and a molecular lead separate of 2d ≅ 100 A. The fitting parameters that are determined in this procedure are applied to help establish the structural characteristics of the particular multilayer

  11. Comparación de dos test psicofísicos de sensibilidad al contraste en un entorno clínico

    Directory of Open Access Journals (Sweden)

    Elisa Colombo

    2011-01-01

    Full Text Available El objetivo de este estudio fue comparar el desempeño de dos test psicofísicos de sensibilidad al contraste, uno basado en un sistema informatizado - FVC 100 - y otro en láminas impresas - VCTS 6500, ambos empleando la discriminación de redes sinusoidales en condiciones de adaptación fotópica. Fueron medidos 45 ojos de 23 personas con edades entre 28 y 70 años. Los sujetos fueron reclutados en un Servicio de Oftalmología al cual concurrieron tanto por consulta como por control. A partir de tomar el criterio clínico como referencia, los resultados muestran que, de los 23 sujetos, en 16 casos ambos sistemas detectaron correctamente su estado visual, en cinco casos (10 ojos sólo el FVC 100 consiguió hacerlo, mientras que en dos casos este sistema no detectó el problema visual y sí lo hizo el VCTS 6500. Considerando los datos obtenidos se aprecia un mejor desempeño del test informatizado, destacándose la necesidad de continuar trabajando para conseguir un atlas con información de la función de sensibilidad al contraste que considere las diferentes patologías visuales.

  12. Preliminary observation on the effect of baking soda volume on controlling odour from discarded organic waste

    International Nuclear Information System (INIS)

    Qamaruz-Zaman, N.; Kun, Y.; Rosli, R.-N.

    2015-01-01

    Highlights: • Approximately 50 g baking soda reduced odour concentration by 70%. • Reducing volatile acid concentration reduces odour concentration. • Ammonia has less effect on odour concentration. - Abstract: Food wastes with high moisture and organic matter content are likely to emit odours as a result of the decomposition process. The management of odour from decomposing wastes is needed to sustain the interest of residents and local councils in the source separation of kitchen wastes. This study investigated the potential of baking soda (at 50 g, 75 g and 100 g per kg food waste) to control odour from seven days stored food waste. It was found that 50 g of baking soda, spread at the bottom of 8 l food wastes bin, can reduce the odour by about 70%. A higher amount (above 100 g) is not advised as a pH higher than 9.0 may be induced leading to the volatilization of odorous ammonia. This research finding is expected to benefit the waste management sector, food processing industries as well as the local authorities where malodour from waste storage is a pressing issue

  13. Characteristic values for the forming of the magnesium alloy AZ31

    International Nuclear Information System (INIS)

    Doege, E.; Janssen, S.; Wieser, J.

    2001-01-01

    The aim of investigation and development at the institute for metal forming and metal forming machine tools (IFUM) at the University of Hanover, Germany is to advance magnesium forming scientifically which has so far been based on experience and empirically determined process data only. Optimized process parameter with a sound material scientific and process control base have to be determined for the deformation of magnesium wrought alloys in order to broaden the technical use of such alloys. Aim of the investigations introduced in this paper is the determination of characteristic values as well-founded basis for the forming technological processing of magnesium wrought alloys in massive forming processes. The basic data for the description of the deformation ability in the form of friction factor and flow curve is to be detected, especially in connection with the integration into an FEM-simulation. In order to achieve such data for the magnesium wrought alloy AZ31 the flow curve at temperatures between 250 and 300 C and the deformation ratio 1, 10, 20 and 30 are presented. On the other hand a ring upsetting test for the determination of the friction factor at altitude reductions of 30, 50, 70%, a tool temperature of 200 C, a work piece temperature between 300 and 400 C and different lubricants are shown for the said alloy. (orig.)

  14. The Formation of Composite Ti-Al-N Coatings Using Filtered Vacuum Arc Deposition with Separate Cathodes

    Directory of Open Access Journals (Sweden)

    Ivan A. Shulepov

    2017-11-01

    Full Text Available Ti-Al-N coatings were deposited on high-speed steel substrates by filtered vacuum arc deposition (FVAD during evaporation of aluminum and titanium cathodes. Distribution of elements, phase composition, and mechanical properties of Ti-Al-N coatings were investigated using Auger electron spectroscopy (AES, X-ray diffraction (XRD, transmission electron microscopy (TEM and nanoindentation, respectively. Additionally, tribological tests and scratch tests of the coatings were performed. The stoichiometry of the coating changes from Ti0.6Al0.4N to Ti0.48Al0.52N with increasing aluminum arc current from 70 A to 90 A, respectively. XRD and TEM showed only face-centered cubic Ti-Al-N phase with preferred orientation of the crystallites in (220 direction with respect to the sample normal and without precipitates of AlN or intermetallics inside the coatings. Incorporation of Al into the TiN lattice caused shifting of the (220 reflex to a higher 2θ angle with increasing Al content. Low content and size of microdroplets were obtained using coaxial plasma filters, which provides good mechanical and tribological properties of the coatings. The highest value of microhardness (36 GPa and the best wear-resistance were achieved for the coating with higher Al content, thus for Ti0.48Al0.52N. These coatings exhibit good adhesive properties up to 30 N load in the scratch tests.

  15. Differentiation of prostate cancer lesions with high and with low Gleason score by diffusion-weighted MRI

    Energy Technology Data Exchange (ETDEWEB)

    Barbieri, Sebastiano; Broennimann, Michael; Vermathen, Peter; Thoeny, Harriet C. [Inselspital University Hospital, Institute of Diagnostic, Pediatric, and Interventional Radiology, Bern (Switzerland); Boxler, Silvan [Inselspital, Inselspital University Hospital, Department of Urology, Bern (Switzerland)

    2017-04-15

    To differentiate prostate cancer lesions with high and with low Gleason score by diffusion-weighted-MRI (DW-MRI). This prospective study was approved by the responsible ethics committee. DW-MRI of 84 consenting prostate and/or bladder cancer patients scheduled for radical prostatectomy were acquired and used to compute apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM: the pure diffusion coefficient D{sub t}, the pseudo-diffusion fraction F{sub p} and the pseudo-diffusion coefficient D{sub p}), and high b value (as acquired and Hessian filtered) parameters within the index lesion. These parameters (separately and combined in a logistic regression model) were used to differentiate lesions depending on whether whole-prostate histopathological analysis after prostatectomy determined a high (≥7) or low (6) Gleason score. Mean ADC and D{sub t} differed significantly (p of independent two-sample t test < 0.01) between high- and low-grade lesions. The highest classification accuracy was achieved by the mean ADC (AUC 0.74) and D{sub t} (AUC 0.70). A logistic regression model based on mean ADC, mean F{sub p} and mean high b value image led to an AUC of 0.74 following leave-one-out cross-validation. Classification by IVIM parameters was not superior to classification by ADC. DW-MRI parameters correlated with Gleason score but did not provide sufficient information to classify individual patients. (orig.)

  16. COMPORTAMENTOS DE SAÚDE E VARIÁVEIS ANTROPOMÉTRICAS ENTRE IDOSOS COM E SEM HIPERTENSÃO ARTERIAL SISTÊMICA

    Directory of Open Access Journals (Sweden)

    Nayara Paula Fernandes Martins

    2015-01-01

    Full Text Available Se objetivó describir las variables socioeconómicas, demográficas y morbilidades y comparar la prevalencia y las probabilidades de prevalencia de conductas de salud, exceso de peso, la circunferencia abdominal y los indicadores de depresión entre las personas con y sin hipertensión. Estudio transversal realizado con ancianos de zonas rurales. Se realizó un análisis descriptivo, prueba de Chi-cuadrado y regresión logística binaria múltiple (p<0,05. Predominaron en ambos grupos, edades de 60├70 años, casado, 4├8 años de estudio, ingresos de un salario mínimo y que vivían con su cónyuge. Los pacientes ancianos con hipertensión tenían menos probabilidades de prevalencia del consumo de alcohol y el tabaco y las probabilidades más altas de sobrepeso, circunferencia abdominal inapropiada e indicativo de depresión en comparación con aquellos sin hipertensión. Se refuerza la importancia de las acciones de salud dirigidas a los ancianos de zonas rurales, a través de la cesación del consumo de tabaco y alcohol, control de peso y reducción de la circunferencia abdominal entre las personas con hipertensión.

  17. Second International Conference on Batteries for Utility Energy Storage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-07-24

    This is a collection of essays presented at the above-named conference held at New Port Beach, U.S., from July 24 through 28, 1989. At the utility energy storage session, it is found that the 100kW-capable Na-S battery system of the Kansai Electric Power Company, Inc., works effectively in levelling peakloads at storage efficiency of 70%. A Chino lead-acid battery system is also described. A lead-acid battery system of the BEWAG Corporation of Germany equipped with tubular electrodes is described. For application by the consuming party, system behavior relative to duty cycle control, sudden request for energy storage, power factor, and load adjustment is discussed. Use of a valve-controlled lead-acid battery is introduced, which is to be used as a stand-by system (such as an uninterruptible power supply) or for certain types of cyclic duties. At the 4th session, economic and technical models are exhibited. Computer-aided peakload prediction, battery storage system technology, economic parameters, profitability, etc., are explained for use by the consuming party in a peakload shaving battery system. The Zn/Br battery, redox-flow battery, and other advanced technologies are also presented. (NEDO)

  18. Inverse association of serum vitamin D in relation to carotid intima-media thickness in Chinese postmenopausal women.

    Science.gov (United States)

    Hao, Yaping; Ma, Xiaojing; Luo, Yuqi; Xu, Yiting; Xiong, Qin; Zhu, Jiaan; Bao, Yuqian; Jia, Weiping

    2015-01-01

    This study aimed to investigate the relationship between serum vitamin D level and carotid intima-media thickness (C-IMT) in Chinese postmenopausal women. Nine hundred and twenty six Chinese postmenopausal women without carotid artery plaque or history of cardiovascular disease were selected for analysis. Measurements of serum 25 hydroxyvitamin D3 (25(OH)D3) concentration and C-IMT were made by electrochemiluminescence immunoassay and B-mode ultrasound, respectively. Trend analysis was conducted according to tertiles of C-IMT. The median serum 25(OH)D3 level was 11.03 ng/mL, with an interquartile range of 8.22-14.70. A decreasing trend of serum 25(OH)D3 level was accompanied by increased C-IMT tertiles (P for trend = 0.001). Correlation analysis found an inverse relationship between serum 25(OH)D3 level and C-IMT (r = -0.113, P = 0.001). After adjustment for confounding factors, multiple regression analysis showed that serum 25(OH)D3 level independently and negatively associated with C-IMT (Standard β = -0.112, P women with normal glucose tolerance, blood pressure and body mass index, and without undergoing lipid-lowering therapy (standard β = -0.140, P = 0.018). Serum 25(OH)D3 level was inversely correlated with C-IMT in Chinese postmenopausal women.

  19. Preparation of mandatory documentation before the start up of the RA-0 `zero power` nuclear reactor at Cordoba National University; Preparacion de la documentacion mandatoria para la puesta en marcha del reactor nuclear RA-0 en la Universidad Nacional de Cordoba

    Energy Technology Data Exchange (ETDEWEB)

    Martin, H R; Keil, W M; Pezzi, N

    1992-12-31

    Before the start up of the RA-0 `zero power` nuclear reactor installed at Cordoba National University, it was necessary to send to the Regulatory Authority the mandatory documentation which is required in the licensing process. With the previous papers existing for the operation in the first years of the `70, a work program for the future operational training personnel was elaborated. Based on the Authority`s applicable rules and the recommendations and with particular criteria originated in the working university conditions, the SAFETY report of RA-0 nuclear reactor was prepared. This paper describes the principal contents, items and documents involved in the safety report. (Author). [Espanol] Con motivo de la nueva puesta en servicio del REACTOR NUCLEAR RA-0 fue necesario elaborar la documentacion mandatoria requerida por la Autoridad Regulatoria Nacional. Siguiendo los lineamientos de las normas y recomendaciones vigentes e incluyendo criterios propios en lo que debia ser el contenido final de dicha documentacion, fue preparado lo que se ha denominado el INFORME DE SEGURIDAD DEL REACTOR NUCLEAR RA-0. Este documento que se describe en este trabajo, si bien contiene las habituales descripciones de todos los Informes de Seguridad, incluye otros aspectos que no siendo requeridos expresamente en el mismo, han dado una mayor coherencia a la conformacion de todos los aspectos que interrelacionan las areas de seguridad fisica, radiologica, nuclear y de control de materiales nucleares bajo salvaguardias. (Autor).

  20. Avaliação multidimensional dos determinantes do envelhecimento ativo em idosos de um município de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Fernanda Regina Vicente

    2013-01-01

    Full Text Available Este estúdio tuvo como objetivo evaluar los determinantes del envejecimiento activo en ancianos de 60 a 70 años residentes en Rodeio-SC. Estudio cuantitativo, exploratorio-descriptivo, cuya recopilación de datos ocurrió entre Abril y Agosto del 2011. Entrevistados 264 ancianos en sus hogares mediante utilización del instrumento para evaluación multidimensional del envejecimiento activo, después de la validación de contenido, realizada por peritos. Los datos fueron organizados en una hoja de cálculo en Microsoft Excel, y después se utilizo lo programa SestatNet para el análisis descriptivo. Los ancianos eran participativos en la comunidad y realizaban trabajo no remunerado (90,9%. Presentaron índice significativo de caídas (30,68%, pero, baja hospitalización (4,92%. Apesar de las comorbidades, los ancianos se mostraron satisfechos con sus vidas, realizaban actividades de recreación y físicas, regularmente. Se concluyó que si bien no todos los ancianos consiguieron una evaluación positiva en cada determinante del envejecimiento activo, de manera general, se mostraron independientes y satisfechos com su cualidad de vida.

  1. Lombalgia: revisão de conceitos e métodos de tratamentos - doi: 10.5102/ucs.v6i2.718

    Directory of Open Access Journals (Sweden)

    Renata Alice Miateli Pires

    2009-07-01

    Full Text Available Dores lombares são alterações músculos-esqueléticas mais comuns nas sociedades industrializadas e acometem entre 70% a 80,5% da população em ambos os sexos. As algias são decorrentes ao esforço requerido para atividades do trabalho e da vida diária. Sendo evidenciadas como sinais clínicos, a imobilidade e a deformidade antálgica para as quais, qualquer tentativa de movimento ativo ou passivo irá produzir a dor. Observou-se que em exercícios orientados (alongamento, caminhar, natação entre outros há uma redução das dores lombares subagudas ou crônicas, além da melhora da disfunção física e psicológica e prevenção da recorrência. Outro item analisado é que o alongamento associado ao ultrassom proporciona uma redução rápida das algias. Logo, a lombalgia é uma das patologias mais estudadas na área médica em questão de estudo etiológica e sintomatologia clínica in vivo. Entretanto, esses estudos envolvem tratamentos conservadores, ou alternativos, invasivos com uso de medicamentosos. Isso, sendo pouco aproveitado no campo fisioterápico.

  2. Energy Potential and Greenhouse Gas Emissions from Bioenergy Cropping Systems on Marginally Productive Cropland

    Science.gov (United States)

    Schmer, Marty R.; Vogel, Kenneth P.; Varvel, Gary E.; Follett, Ronald F.; Mitchell, Robert B.; Jin, Virginia L.

    2014-01-01

    Low-carbon biofuel sources are being developed and evaluated in the United States and Europe to partially offset petroleum transport fuels. Current and potential biofuel production systems were evaluated from a long-term continuous no-tillage corn (Zea mays L.) and switchgrass (Panicum virgatum L.) field trial under differing harvest strategies and nitrogen (N) fertilizer intensities to determine overall environmental sustainability. Corn and switchgrass grown for bioenergy resulted in near-term net greenhouse gas (GHG) reductions of −29 to −396 grams of CO2 equivalent emissions per megajoule of ethanol per year as a result of direct soil carbon sequestration and from the adoption of integrated biofuel conversion pathways. Management practices in switchgrass and corn resulted in large variation in petroleum offset potential. Switchgrass, using best management practices produced 3919±117 liters of ethanol per hectare and had 74±2.2 gigajoules of petroleum offsets per hectare which was similar to intensified corn systems (grain and 50% residue harvest under optimal N rates). Co-locating and integrating cellulosic biorefineries with existing dry mill corn grain ethanol facilities improved net energy yields (GJ ha−1) of corn grain ethanol by >70%. A multi-feedstock, landscape approach coupled with an integrated biorefinery would be a viable option to meet growing renewable transportation fuel demands while improving the energy efficiency of first generation biofuels. PMID:24594783

  3. Characterization of the Antibiotic Compound No. 70 Produced by Streptomyces sp. IMV-70

    Science.gov (United States)

    Trenozhnikova, Lyudmila P.; Khasenova, Almagul K.; Balgimbaeva, Assya S.; Fedorova, Galina B.; Katrukha, Genrikh S.; Tokareva, Nina L.; Kwa, Boo H.; Azizan, Azliyati

    2012-01-01

    We describe the actinomycete strain IMV-70 isolated from the soils of Kazakhstan, which produces potent antibiotics with high levels of antibacterial activity. After the research of its morphological, chemotaxonomic, and cultural characteristics, the strain with potential to be developed further as a novel class of antibiotics with chemotherapeutics potential was identified as Streptomyces sp. IMV-70. In the process of fermentation, the strain Streptomyces spp. IMV-70 produces the antibiotic no. 70, which was isolated from the culture broth by extraction with organic solvents. Antibiotic compound no. 70 was purified and separated into individual components by HPLC, TLC, and column chromatography methods. The main component of the compound is the antibiotic 70-A, which was found to be identical to the peptolide etamycin A. Two other antibiotics 70-B and 70-C have never been described and therefore are new antibiotics. The physical-chemical and biological characteristics of these preparations were described and further researched. Determination of the optimal growth conditions to cultivate actinomycete-producer strain IMV-70 and development of methods to isolate, purify, and accumulate preparations of the new antibiotic no. 70 enable us to research further the potential of this new class of antibiotics. PMID:22536145

  4. Assessing Reliability of a Multi-Dimensional Scale by Coefficient Alpha

    Directory of Open Access Journals (Sweden)

    Ivan Šerbetar

    2016-04-01

    Full Text Available The purpose of the study was to assess internal consistency by calculating coefficient alpha. It presents the variation in coefficient alpha, depending on questionnaire length and the homogeneity or heterogeneity of the questionnaire. The maximum possible value for coefficient alpha was also calculated by the item elimination method. The study included 99 children aged 10. The children completed The Athletic Coping Skills Inventory – 28 (ACSI-28; Smith et al., 1995, which contains seven constructs: coping with adversity, coachability, concentration, confidence and achievement motivation, goal setting and mental preparation, peaking under pressure and freedom from worry. The results confirmed that the values of the alpha coefficient vary depending on the number and composition of items and the sample size. In terms of item structure, homogeneous constructs yielded lower values for the alpha coefficient (in a range from .48 to .61 than the questionnaire with all the constructs (alpha = .79, despite higher inter-item correlations. In terms of the number of items, the longer test generated higher alpha coefficients (alpha = .79 than the shorter test (half-sets of items = .60, .73, .69, .70. A higher overall value (alpha = .83 can be achieved by item elimination.

  5. Leucemias agudas en ancianos de la provincia de Santiago de Cuba

    Directory of Open Access Journals (Sweden)

    Lidia Clara Suárez Beyríes

    2015-04-01

    Full Text Available Se realizó un estudio descriptivo y retrospectivo de 64 pacientes mayores de 60 años con leucemia aguda, atendidos en el Servicio de Hematología del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, durante el quinquenio 2006-2011, para determinar las principales características clínicas y hematológicas en el momento del diagnóstico, así como la supervivencia global de los afectados, aunque los tratamientos administrados no tenían criterio curativo. La edad promedio de los ancianos fue de 70 años, en un rango etario de 60 a 90; en tanto, la variedad no linfoblástica representó 98,4 %, y todos los pacientes presentaron anemia y trombocitopenia como alteraciones hematológicas, con incremento en los requerimientos transfusionales. De igual forma, la presencia de blastos en la sangre periférica se demostró en 50 % y la hiperleucocitosis en 59,4 %, mientras las principales causas de muerte estuvieron relacionadas con la hemorragia cerebral y la progresión de la enfermedad con la infiltración multiorgánica, lo cual condujo a una supervivencia muy corta de los integrantes de la serie

  6. Polarization Characteristics of Zebra Patterns in Type IV Solar Radio Bursts

    International Nuclear Information System (INIS)

    Kaneda, K.; Misawa, H.; Tsuchiya, F.; Obara, T.; Iwai, K.; Katoh, Y.; Masuda, S.

    2017-01-01

    The polarization characteristics of zebra patterns (ZPs) in type IV solar bursts were studied. We analyzed 21 ZP events observed by the Assembly of Metric-band Aperture Telescope and Real-time Analysis System between 2010 and 2015 and identified the following characteristics: a degree of circular polarization (DCP) in the range of 0%–70%, a temporal delay of 0–70 ms between the two circularly polarized components (i.e., the right- and left-handed components), and dominant ordinary-mode emission in about 81% of the events. For most events, the relation between the dominant and delayed components could be interpreted in the framework of fundamental plasma emission and depolarization during propagation, though the values of DCP and delay were distributed across wide ranges. Furthermore, it was found that the DCP and delay were positively correlated (rank correlation coefficient R = 0.62). As a possible interpretation of this relationship, we considered a model based on depolarization due to reflections at sharp density boundaries assuming fundamental plasma emission. The model calculations of depolarization including multiple reflections and group delay during propagation in the inhomogeneous corona showed that the DCP and delay decreased as the number of reflections increased, which is consistent with the observational results. The dispersive polarization characteristics could be explained by the different numbers of reflections causing depolarization.

  7. Structure of Cowpea mottle virus: a consensus in the genus Carmovirus

    International Nuclear Information System (INIS)

    Ke Jiyuan; Schmidt, Timothy; Chase, Elaine; Bozarth, Robert F.; Smith, Thomas J.

    2004-01-01

    Cowpea mottle virus (CPMoV) is a T = 3 virus that belongs to Carmovirus genus of the Tombusviridae family. Here, we report the crystal structure of CPMoV determined to a resolution of 7.0 A. The structures and sequences of three Carmoviruses, CPMoV, Turnip crinkle virus (TCV), and Carnation mottle virus (CarMV) have been compared to TBSV from the Tombusvirus genus. CPMoV, TCV, and CarMV all have a deletion in βC strand in the S domain relative to TBSV that may be distinctive to the genus. Although CPMoV has an elongated C-terminus like TBSV, it does not interact with the icosahedrally related P domain as observed in TBSV. In CPMoV, the termini of A and B interact with the icosahedrally related shell domains of A and C, respectively, to form a chain of interactions around the 5-fold axes. The C subunit terminus does not, however, interact with the B subunit because of quasi-equivalent differences in the P domain orientations

  8. Usage patterns of aromatherapy among the French general population: A descriptive study focusing on dermal exposure.

    Science.gov (United States)

    Dornic, N; Ficheux, A S; Roudot, A C; Saboureau, D; Ezzedine, K

    2016-04-01

    Although likely benefits of aromatherapy are well documented, little is known about essential oils consumption and exposure to molecules present in the oils. The aim of our study was to determine usage patterns of 12 types of essential oils among a quite large panel, sorted per sex and quintile of age from birth to 70. A survey was conducted in September 2014 among 1507 French individuals, selected to build a representative panel of the general population. The key point of our study, apart from the fact that it has never been done among general population, was the focus on dermal exposure. Information about types of essential oils used, skin areas exposed, frequencies and quantities were collected. Our work revealed that some sub-populations could be significantly exposed to molecules of toxicological concern, especially in terms of skin sensitization. This work is the first step to assess human exposure to these molecules, and will help safety authorities and risk managers to protect the population. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. A written language intervention for at-risk second grade students: a randomized controlled trial of the process assessment of the learner lesson plans in a tier 2 response-to-intervention (RtI) model.

    Science.gov (United States)

    Hooper, Stephen R; Costa, Lara-Jeane C; McBee, Matthew; Anderson, Kathleen L; Yerby, Donna Carlson; Childress, Amy; Knuth, Sean B

    2013-04-01

    In a randomized controlled trial, 205 students were followed from grades 1 to 3 with a focus on changes in their writing trajectories following an evidence-based intervention during the spring of second grade. Students were identified as being at-risk (n=138), and then randomized into treatment (n=68) versus business-as-usual conditions (n=70). A typical group also was included (n=67). The writing intervention comprised Lesson Sets 4 and 7 from the Process Assessment of the Learner (PAL), and was conducted via small groups (three to six students) twice a week for 12 weeks in accordance with a response-to-intervention Tier 2 model. The primary outcome was the Wechsler Individual Achievement Test-II Written Expression Scale. Results indicated modest support for the PAL lesson plans, with an accelerated rate of growth in writing skills following treatment. There were no significant moderator effects, although there was evidence that the most globally impaired students demonstrated a more rapid rate of growth following treatment. These findings suggest the need for ongoing examination of evidence-based treatments in writing for young elementary students.

  10. Intense atmospheric pollution modifies weather: a case of mixed biomass burning with fossil fuel combustion pollution in eastern China

    Science.gov (United States)

    Ding, A. J.; Fu, C. B.; Yang, X. Q.; Sun, J. N.; Petäjä, T.; Kerminen, V.-M.; Wang, T.; Xie, Y.; Herrmann, E.; Zheng, L. F.; Nie, W.; Liu, Q.; Wei, X. L.; Kulmala, M.

    2013-10-01

    The influence of air pollutants, especially aerosols, on regional and global climate has been widely investigated, but only a very limited number of studies report their impacts on everyday weather. In this work, we present for the first time direct (observational) evidence of a clear effect of how a mixed atmospheric pollution changes the weather with a substantial modification in the air temperature and rainfall. By using comprehensive measurements in Nanjing, China, we found that mixed agricultural burning plumes with fossil fuel combustion pollution resulted in a decrease in the solar radiation intensity by more than 70%, a decrease in the sensible heat by more than 85%, a temperature drop by almost 10 K, and a change in rainfall during both daytime and nighttime. Our results show clear air pollution-weather interactions, and quantify how air pollution affects weather via air pollution-boundary layer dynamics and aerosol-radiation-cloud feedbacks. This study highlights cross-disciplinary needs to investigate the environmental, weather and climate impacts of the mixed biomass burning and fossil fuel combustion sources in East China.

  11. The diagnostic value of [18F]FDG PET for the detection of chronic osteomyelitis and implant-associated infection

    International Nuclear Information System (INIS)

    Wenter, Vera; Albert, Nathalie L.; Lehner, Sebastian; Fendler, Wolfgang P.; Bartenstein, Peter; Mueller, Jan-Phillip; Friederichs, Jan; Militz, Matthias; Hungerer, Sven; Cyran, Clemens C.; Hacker, Marcus

    2016-01-01

    The diagnosis of osteomyelitis and implant-associated infections in patients with nonspecific laboratory or radiological findings is often unsatisfactory. We retrospectively evaluated the contributions of [ 18 F]FDG PET and [ 18 F]FDG PET/CT to the diagnosis of osteomyelitis and implant-associated infections, enabling timely and appropriate decision-making for further therapy options. [ 18 F]FDG PET or PET/CT was performed in 215 patients with suspected osteomyelitis or implant-associated infections between 2000 and 2013. We assessed the diagnostic accuracy of both modalities together and separately with reference to intraoperative microbial findings, with a mean clinical follow-up of 69 ± 49 months. Infections were diagnosed clinically in 101 of the 215 patients. PET and PET/CT scans revealed 87 true-positive, 76 true-negative, 38 false-positive, and 14 false-negative results, indicating a sensitivity of 86 %, a specificity of 67 %, a positive predictive value (PPV) of 70 %, a negative predictive value (NPV) of 84 % and an accuracy of 76 %. The sensitivity of PET/CT was 88 %, but specificity, PPV, NPV and accuracy (76 %, 76 %, 89 % and 82 %, respectively) were higher than those of stand-alone PET. [ 18 F]FDG PET is able to identify with high sensitivity the presence of osteomyelitis in orthopaedic surgery patients with nonspecific clinical symptoms of infection. (orig.)

  12. Effects of Marine Oils, Digested with Human Fluids, on Cellular Viability and Stress Protein Expression in Human Intestinal Caco-2 Cells

    Directory of Open Access Journals (Sweden)

    Cecilia Tullberg

    2017-11-01

    Full Text Available In vitro digestion of marine oils has been reported to promote lipid oxidation, including the formation of reactive aldehydes (e.g., malondialdehyde (MDA and 4-hydroxy-2-hexenal (HHE. We aimed to investigate if human in vitro digestion of supplemental levels of oils from algae, cod liver, and krill, in addition to pure MDA and HHE, affect intestinal Caco-2 cell survival and oxidative stress. Cell viability was not significantly affected by the digests of marine oils or by pure MDA and HHE (0–90 μM. Cellular levels of HSP-70, a chaperone involved in the prevention of stress-induced protein unfolding was significantly decreased (14%, 28%, and 14% of control for algae, cod and krill oil, respectively; p ≤ 0.05. The oxidoreductase thioredoxin-1 (Trx-1 involved in reducing oxidative stress was also lower after incubation with the digested oils (26%, 53%, and 22% of control for algae, cod, and krill oil, respectively; p ≤ 0.001. The aldehydes MDA and HHE did not affect HSP-70 or Trx-1 at low levels (8.3 and 1.4 μM, respectively, whilst a mixture of MDA and HHE lowered Trx-1 at high levels (45 μM, indicating less exposure to oxidative stress. We conclude that human digests of the investigated marine oils and their content of MDA and HHE did not cause a stress response in human intestinal Caco-2 cells.

  13. The importance of mammography in relationship to the number of treated carcinomas of the breast

    International Nuclear Information System (INIS)

    Paterok, E.M.; Weishaar, J.; Bischoff, J.; Mueller, D.

    1980-01-01

    From 1976 to 1978 11,197 women were examined clinically and mammographically. Biopsy material from 1,673 breasts were examined microscopically. In 536 cases, or almost every third case a carcinoma of the breast was detected. The cancer was bilateral in 19 cases and the total number of women was therefore 517. A clinically occult tumour was only found in 7.7% of the cases. 5% of these patients were high risk patients and 2.7% preventive examinations. 5 women with occult carcinoma of the breast were under age 40 and 14 under age 50. Benign changes of the glandular tissue were found in 59.5% of the cases. Marked proliferative changes were found in 4.6% of the cases and carcinoma in situ was found in 3.8% of the patients. In the age group 45-54 benign and malignant findings was 1:1 in the age group 55-59 and was less than 1:2 in the age group over 70. A sophistication of the mammographic technique must be obtained. A thorough microscopic examination of tissue from subcutaneous mastectomies and tissue obtained at the time of reduction mammoplasties showed occasionally unexpected malignant tissue in an unexpected location. Expecially these cases are suitable for later comparison to the mammographies. (orig./MG) [de

  14. Rational hybrid modulation of P, N dual-doped holey graphene for high-performance supercapacitors

    Science.gov (United States)

    Nazarian-Samani, Masoud; Haghighat-Shishavan, Safa; Nazarian-Samani, Mahboobeh; Kim, Myeong-Seong; Cho, Byung-Won; Oh, Si-Hyoung; Kashani-Bozorg, Seyed Farshid; Kim, Kwang-Bum

    2017-12-01

    A P, N dual-doped holey graphene (PNHG) material is prepared by a scalable, facile synthetic approach, using a mixture of glucose, dicyandiamide (DCDA), and phosphoric acid (H3PO4). H3PO4 successfully functions as an "acid catalyst" to encourage the uniform breakage of C=C bonds to create large, localized perforations over the graphene monolith. Further acid treatment and annealing introduce in-plane holes. The correlation between the capacitance of the PNHG and its structural parameters during the fabrication process is comprehensively evaluated. A thermally induced sp2→sp3 transformation occurs at high temperatures because of the substantial loss of graphitic sp2-type carbons, together with a dramatic reduction in capacitance. The target PNHG-400 electrode material delivers exceptionally high gravimetric capacitance (235.5 F g-1 at 0.5 A g-1), remarkable rate capability (84.8% at 70 A g-1), superior capacitance retention (93.2 and 92.7% at 10 and 50 A g-1 over 25000 cycles, respectively), and acceptable volumetric capacitance due to moderate density, when it is used with organic electrolytes in the voltage range between 0 and 3 V. These results suggest a pioneering defect-engineered strategy to fabricate dual-doped holey graphene with valuable structural properties for high-performance electric double layer supercapacitors, which could be used in next-generation energy storage applications.

  15. Occupational airborne exposure of the general population of a Norwegian county.

    Science.gov (United States)

    Bakke, P; Baste, V; Hanoa, R; Gulsvik, A

    1992-02-01

    Occupational airborne exposure was examined for a stratified sample (N = 1275) of the general population aged 18-73 years in Hordaland County, Norway. The subjects identified all jobs of more than six months since leaving school and stated whether they had been occupationally exposed to specific agents and work processes potentially harmful to the lungs. The prevalence in the population ever having been exposed was 18% for asbestos, 9% for quartz, 5% for aluminum dust, 6% for wood dust, 12% for metal gases, 12% for welding, 9% for soldering, and 1% for hairdressing. According to occupational title (last job), 3% of the population had held a job with a high degree of airborne exposure, 26% a job with moderate exposure, and 70% a job with no airborne exposure. During their worklife both the men and the women tended to leave polluted jobs more often than unpolluted jobs. Occupational exposure to airborne pollutants potentially harmful to the lungs is widespread in this Norwegian general population.

  16. Characterization of the Antibiotic Compound No. 70 Produced by Streptomyces sp. IMV-70

    Directory of Open Access Journals (Sweden)

    Lyudmila P. Trenozhnikova

    2012-01-01

    Full Text Available We describe the actinomycete strain IMV-70 isolated from the soils of Kazakhstan, which produces potent antibiotics with high levels of antibacterial activity. After the research of its morphological, chemotaxonomic, and cultural characteristics, the strain with potential to be developed further as a novel class of antibiotics with chemotherapeutics potential was identified as Streptomyces sp. IMV-70. In the process of fermentation, the strain Streptomyces spp. IMV-70 produces the antibiotic no. 70, which was isolated from the culture broth by extraction with organic solvents. Antibiotic compound no. 70 was purified and separated into individual components by HPLC, TLC, and column chromatography methods. The main component of the compound is the antibiotic 70-A, which was found to be identical to the peptolide etamycin A. Two other antibiotics 70-B and 70-C have never been described and therefore are new antibiotics. The physical-chemical and biological characteristics of these preparations were described and further researched. Determination of the optimal growth conditions to cultivate actinomycete-producer strain IMV-70 and development of methods to isolate, purify, and accumulate preparations of the new antibiotic no. 70 enable us to research further the potential of this new class of antibiotics.

  17. Effect of irradiation on oxytetracycline residues in poultry meat

    Energy Technology Data Exchange (ETDEWEB)

    Mazurowski, P [Warsaw Agricultural University, Faculty of Veterinary Medicine, Department of Food Hygiene, Warsaw (Poland)

    1994-12-31

    The purpose of the study was an evaluation of the effect of ionizing radiation on detection of oxytetracycline residues in poultry meat. Oxytetracycline was chosen as a representative of tetracyclines which are often applied in poultry for therapeutical reasons. The experiment was conducted using both broiler meat treated by oxytetracycline and slurry of broiler meat containing appropriate concentration of this antibiotic. A traditional microbiological method for determination of antibiotics antimicrobial activity was used. A significant decrease of oxytetracycline concentration in meat slurry as a result of irradiation was noted. A dose of 1 kGy reduced concentration of tetracycline to ca 40% and a dose of 3 kGy reduced it to ca 3%. In ground poultry meat a dose of 1 kGy reduced this antibiotic concentration to 70%, a dose of 3 kGy reduced oxytetracycline concentration to 35% and a 5 kGy dose reduced it up to ca 18% of initial concentration. It can be concluded that irradiation of poultry meat with radurization doses can cause some difficulties in detection of tetracycline residues in meat using traditional microbiological methods of detection. (author).

  18. Effect of irradiation on oxytetracycline residues in poultry meat

    International Nuclear Information System (INIS)

    Mazurowski, P.

    1994-01-01

    The purpose of the study was an evaluation of the effect of ionizing radiation on detection of oxytetracycline residues in poultry meat. Oxytetracycline was chosen as a representative of tetracyclines which are often applied in poultry for therapeutical reasons. The experiment was conducted using both broiler meat treated by oxytetracycline and slurry of broiler meat containing appropriate concentration of this antibiotic. A traditional microbiological method for determination of antibiotics antimicrobial activity was used. A significant decrease of oxytetracycline concentration in meat slurry as a result of irradiation was noted. A dose of 1 kGy reduced concentration of tetracycline to ca 40% and a dose of 3 kGy reduced it to ca 3%. In ground poultry meat a dose of 1 kGy reduced this antibiotic concentration to 70%, a dose of 3 kGy reduced oxytetracycline concentration to 35% and a 5 kGy dose reduced it up to ca 18% of initial concentration. It can be concluded that irradiation of poultry meat with radurization doses can cause some difficulties in detection of tetracycline residues in meat using traditional microbiological methods of detection. (author)

  19. Polarization Characteristics of Zebra Patterns in Type IV Solar Radio Bursts

    Energy Technology Data Exchange (ETDEWEB)

    Kaneda, K.; Misawa, H.; Tsuchiya, F.; Obara, T. [Planetary Plasma and Atmospheric Research Center, Tohoku University, Sendai, Miyagi 980-8578 (Japan); Iwai, K. [National Institute of Information and Communications Technology, 4-2-1, Nukui-Kitamachi, Koganei, Tokyo 184-8795 (Japan); Katoh, Y. [Department of Geophysics, Graduate School of Science, Tohoku University, Sendai, Miyagi 980-8578 (Japan); Masuda, S., E-mail: k.kaneda@pparc.gp.tohoku.ac.jp [Institute for Space—Earth Environmental Research, Nagoya University, Nagoya, Aichi 464-8601 (Japan)

    2017-06-10

    The polarization characteristics of zebra patterns (ZPs) in type IV solar bursts were studied. We analyzed 21 ZP events observed by the Assembly of Metric-band Aperture Telescope and Real-time Analysis System between 2010 and 2015 and identified the following characteristics: a degree of circular polarization (DCP) in the range of 0%–70%, a temporal delay of 0–70 ms between the two circularly polarized components (i.e., the right- and left-handed components), and dominant ordinary-mode emission in about 81% of the events. For most events, the relation between the dominant and delayed components could be interpreted in the framework of fundamental plasma emission and depolarization during propagation, though the values of DCP and delay were distributed across wide ranges. Furthermore, it was found that the DCP and delay were positively correlated (rank correlation coefficient R = 0.62). As a possible interpretation of this relationship, we considered a model based on depolarization due to reflections at sharp density boundaries assuming fundamental plasma emission. The model calculations of depolarization including multiple reflections and group delay during propagation in the inhomogeneous corona showed that the DCP and delay decreased as the number of reflections increased, which is consistent with the observational results. The dispersive polarization characteristics could be explained by the different numbers of reflections causing depolarization.

  20. DC and AC linear magnetic field sensor based on glass coated amorphous microwires with Giant Magnetoimpedance

    International Nuclear Information System (INIS)

    García-Chocano, Víctor Manuel; García-Miquel, Héctor

    2015-01-01

    Giant Magnetoimpedance (GMI) effect has been studied in amorphous glass-coated microwires of composition (Fe 6 Co 94 ) 72.5 Si 12.5 B 15 . The impedance of a 1.5 cm length sample has been characterized by using constant AC currents in the range of 400 µA–4 mA at frequencies from 7 to 15 MHz and DC magnetic fields from −900 to 900 A/m. Double peak responses have been obtained, showing GMI ratios up to 107%. A linear magnetic field sensor for DC and AC field has been designed, using two microwires connected in series with a magnetic bias of 400 A/m with opposite direction in each microwire in order to obtain a linear response from ±70 (A/m) rms for AC magnetic field, and ±100 A/m for DC magnetic field. A closed loop feedback circuit has been implemented to extend the linear range to ±1 kA/m for DC magnetic field. - Highlights: • Giant Magneto Impedance phenomenon has been studied in amorphous microwires. • A combination of two microwires with a bias field has been developed to get a linear response. • An electronic circuit has been developed to obtain a sensor with a linear response. • A feedback coil have been added to increase the measurable range of the sensor

  1. Lühileksikon / Ants Oras

    Index Scriptorium Estoniae

    Oras, Ants

    2007-01-01

    Sisu: William Shakespeareþi sonetid (ilmunud ka: Looming, 1934, nr. 10, lk. 1142-1143, pealkirjaga "Järelmärkus") ; Alexander Popeì "Lokirööv" (ilmunud ka: Looming, 1934, nr. 5, lk. 481-483, pealkirjaga "Järelmärkus") ; Robert Burns (ilmunud ka: Looming, 1939, nr. 7, lk. 756, pealkirjaga "Märkus") ; Lord Byroni "Don Juan" (ilmunud ka: Looming, 1934, nr. 5, lk. 481-483, pealkirjaga: "Sissejuhatav märge") ; John Keatsi luule (ilmunud ka: Looming 1936, nr. 10, lk. 1162, pealkirjaga "Järelmärkus") ; Aleksandr Pushkini looduslüürika (ilmunud ka: Looming, 1934, nr. 1, lk. 68-70, pealkirjaga "Järelmärge") ; Heinrich Heine (ilmunud ka: Looming, 1933, nr. 5, lk. 515-516, pealkirjaga "Saateks") ; Leconte de Lisleì luule (ilmunud ka: Looming, 1939, nr. 8, lk. 869-870, pealkirjaga "Järelmärkus") ; Algernon Swinburne (ilmunud ka: Looming, 191937, nr. 1, lk. 40, pealkirjaga "Järelmärkus") ; Robert Bridges (ilmunud ka: Looming, 1930, nr. 3, lk. 379, pealkirjaga "Inglise poet laureate surnud" (lüh.)) ; Rudyard Kipling (ilmunud ka: Kunst ja Kirjandus, 5. jaanuar 1936, nr. 1, lk. 4, autorinimeta, pealkirjaga "Rudyard Kipling 70-a." ; Robert Frosti luule (ilmunud ka: Tulimuld, 1954, nr. 4, lk. 227-229, 233) ; Vachel Lindsay (ilmunud ka: Looming, 1930, nr. 3, lk. 319-320, pealkirjata)

  2. Analysis of the Sensitivity and Specificity of Noninvasive Imaging Tests for the Diagnosis of Renal Artery Stenosis

    International Nuclear Information System (INIS)

    Borelli, Flavio Antonio de Oliveira; Pinto, Ibraim M. F.; Amodeo, Celso; Smanio, Paola E. P.; Kambara, Antonio M.; Petisco, Ana Claudia G.; Moreira, Samuel M.; Paiva, Ricardo Calil; Lopes, Hugo Belotti; Sousa, Amanda G. M. R.

    2013-01-01

    Aging and atherosclerosis are related to renovascular hypertension in elderly individuals. Regardless of comorbidities, renal artery stenosis is itself an important cause of cardiovascular morbidity and mortality. To define the sensitivity, specificity, positive predictive value, and negative predictive value of noninvasive imaging tests used in the diagnosis of renal artery stenosis. In a group of 61 patients recruited, 122 arteries were analized, thus permitting the definition of sensitivity, specificity, and the relative contribution of each imaging study performed (Doppler, scintigraphy and computed tomographic angiography in comparison to renal arteriography). The mean age was 65.43 years (standard deviation: 8.7). Of the variables related to the study population that were compared to arteriography, two correlated with renal artery stenosis, renal dysfunction and triglycerides. The median glomerular filtration rate was 52.8 mL/min/m 2 . Doppler showed sensitivity of 82.90%, specificity of 70%, a positive predictive value of 85% and negative predictive value of 66.70%. For tomography, sensitivity was 66.70%, specificity 80%, positive predictive value 87.50% and negative predictive value 55.20%. With these findings, we could identify the imaging tests that best detected stenosis. Tomography and Doppler showed good quality and efficacy in the diagnosis of renal artery stenosis, with Doppler having the advantage of not requiring the use of contrast medium for the assessment of a disease that is common in diabetics and is associated with renal dysfunction and severe left ventricular dysfunction

  3. Analysis of the Sensitivity and Specificity of Noninvasive Imaging Tests for the Diagnosis of Renal Artery Stenosis

    Energy Technology Data Exchange (ETDEWEB)

    Borelli, Flavio Antonio de Oliveira, E-mail: fborelli@cardiol.br; Pinto, Ibraim M. F.; Amodeo, Celso; Smanio, Paola E. P.; Kambara, Antonio M.; Petisco, Ana Claudia G.; Moreira, Samuel M.; Paiva, Ricardo Calil; Lopes, Hugo Belotti; Sousa, Amanda G. M. R. [Instituto Dante Pazzanese de Cardiologia, São Paulo, SP (Brazil)

    2013-11-15

    Aging and atherosclerosis are related to renovascular hypertension in elderly individuals. Regardless of comorbidities, renal artery stenosis is itself an important cause of cardiovascular morbidity and mortality. To define the sensitivity, specificity, positive predictive value, and negative predictive value of noninvasive imaging tests used in the diagnosis of renal artery stenosis. In a group of 61 patients recruited, 122 arteries were analized, thus permitting the definition of sensitivity, specificity, and the relative contribution of each imaging study performed (Doppler, scintigraphy and computed tomographic angiography in comparison to renal arteriography). The mean age was 65.43 years (standard deviation: 8.7). Of the variables related to the study population that were compared to arteriography, two correlated with renal artery stenosis, renal dysfunction and triglycerides. The median glomerular filtration rate was 52.8 mL/min/m{sup 2}. Doppler showed sensitivity of 82.90%, specificity of 70%, a positive predictive value of 85% and negative predictive value of 66.70%. For tomography, sensitivity was 66.70%, specificity 80%, positive predictive value 87.50% and negative predictive value 55.20%. With these findings, we could identify the imaging tests that best detected stenosis. Tomography and Doppler showed good quality and efficacy in the diagnosis of renal artery stenosis, with Doppler having the advantage of not requiring the use of contrast medium for the assessment of a disease that is common in diabetics and is associated with renal dysfunction and severe left ventricular dysfunction.

  4. Nucleation and evolution of strain-induced martensitic (b.c.c.) embryos and substructure in stainless steel: a transmission electron microscope study

    International Nuclear Information System (INIS)

    Staudhammer, K.P.; Hecker, S.S.; Murr, L.E.

    1983-01-01

    The deformation of type 304 stainless steel produces a preponderance of strain-induced /chi/ (b.c.c.) martensite, which nucleates as stable embryos at micro-shear band or twin-fault intersections as proposed by Olson and Cohen. The two intersecting micro-shear bands must have a specific defect (fault-displacement) structure, and for stable martensite embryos to form requires a minimal micro-shear band thickness ranging from 50-70 A. The critical nature of nucleation is influenced by the local temperature and strain. The structure, geometry, and morphology of strain-induced martensite embryos is essentially invariant regardless of the strain rate, strain state or temperature. Larger volume fractions of martensite evolve at large strains (greater than or equal to 20%) as a result of embryo coalescence to produce a blocky-type morphology. Martensite embryos and coalesced volume elements of /chi/ are frequently characterized by an irregular non-homogeneous distribution of smaller b.c.c. regimes which result from the irregular satisfaction of the necessary and specific fault-displacement requirements within a larger intersection volume

  5. Incidental perifissural nodules on routine chest computed tomography. Lung cancer or not?

    Energy Technology Data Exchange (ETDEWEB)

    Mets, Onno M.; Veldhuis, Wouter B.; Jong, Pim A. de [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Chung, Kaman; Scholten, Ernst T.; Ginneken, Bram van [Radboud University Nijmegen Medical Centre, Diagnostic Image Analysis Group, Nijmegen (Netherlands); Prokop, M. [Radboud University Nijmegen Medical Centre, Department of Radiology, Nijmegen (Netherlands); Schaefer-Prokop, Cornelia M. [Radboud University Nijmegen Medical Centre, Diagnostic Image Analysis Group, Nijmegen (Netherlands); Meander Medical Center, Department of Radiology, Amersfoort (Netherlands)

    2018-03-15

    Perifissural nodules (PFNs) are a common finding on chest CT, and are thought to represent non-malignant lesions. However, data outside a lung cancer-screening setting are currently lacking. In a nested case-control design, out of a total cohort of 16,850 patients ≥ 40 years of age who underwent routine chest CT (2004-2012), 186 eligible subjects with incident lung cancer and 511 controls without were investigated. All non-calcified nodules ≥ 4 mm were semi-automatically annotated. Lung cancer location and subject characteristics were recorded. Cases (56 % male) had a median age of 64 years (IQR 59-70). Controls (60 % male) were slightly younger (p<0.01), median age of 61 years (IQR 51-70). A total of 262/1,278 (21 %) unique non-calcified nodules represented a PFN. None of these were traced to a lung malignancy over a median follow-up of around 4.5 years. PFNs were most often located in the lower lung zones (72 %, p<0.001). Median diameter was 4.6 mm (range: 4.0-8.1), volume 51 mm{sup 3} (range: 32-278). Some showed growth rates < 400 days. Our data show that incidental PFNs do not represent lung cancer in a routine care, heterogeneous population. This confirms prior screening-based results. (orig.)

  6. Genome sequence of the lager brewing yeast, an interspecies hybrid.

    Science.gov (United States)

    Nakao, Yoshihiro; Kanamori, Takeshi; Itoh, Takehiko; Kodama, Yukiko; Rainieri, Sandra; Nakamura, Norihisa; Shimonaga, Tomoko; Hattori, Masahira; Ashikari, Toshihiko

    2009-04-01

    This work presents the genome sequencing of the lager brewing yeast (Saccharomyces pastorianus) Weihenstephan 34/70, a strain widely used in lager beer brewing. The 25 Mb genome comprises two nuclear sub-genomes originating from Saccharomyces cerevisiae and Saccharomyces bayanus and one circular mitochondrial genome originating from S. bayanus. Thirty-six different types of chromosomes were found including eight chromosomes with translocations between the two sub-genomes, whose breakpoints are within the orthologous open reading frames. Several gene loci responsible for typical lager brewing yeast characteristics such as maltotriose uptake and sulfite production have been increased in number by chromosomal rearrangements. Despite an overall high degree of conservation of the synteny with S. cerevisiae and S. bayanus, the syntenies were not well conserved in the sub-telomeric regions that contain lager brewing yeast characteristic and specific genes. Deletion of larger chromosomal regions, a massive unilateral decrease of the ribosomal DNA cluster and bilateral truncations of over 60 genes reflect a post-hybridization evolution process. Truncations and deletions of less efficient maltose and maltotriose uptake genes may indicate the result of adaptation to brewing. The genome sequence of this interspecies hybrid yeast provides a new tool for better understanding of lager brewing yeast behavior in industrial beer production.

  7. Transforming growth factor beta activity in urine of patients with type 2 diabetes and diabetic nephropathy

    Directory of Open Access Journals (Sweden)

    Rivarola E.W.R.

    1999-01-01

    Full Text Available Diabetic nephropathy (DN is characterized structurally by progressive mesangial deposition of extracellular matrix (ECM. Transforming growth factor-ß (TGF-ß is considered to be one of the major cytokines involved in the regulation of ECM synthesis and degradation. Several studies suggest that an increase in urinary TGF-ß levels may reflect an enhanced production of this polypeptide by the kidney cells. We evaluated TGF-ß in occasional urine samples from 14 normal individuals and 23 patients with type 2 diabetes (13 with persistent proteinuria >500 mg/24 h, DN, 6 with microalbuminuria, DMMA, and 4 with normal urinary albumin excretion, DMN by enzyme immunoassay. An increase in the rate of urinary TGF-ß excretion (pg/mg UCreat. was observed in patients with DN (296.07 ± 330.77 (P<0.001 compared to normal individuals (17.04 ± 18.56 (Kruskal-Wallis nonparametric analysis of variance; however, this increase was not observed in patients with DMMA (25.13 ± 11.30 or in DMN (18.16 ± 11.82. There was a positive correlation between the rate of urinary TGF-ß excretion and proteinuria (r = 0.70, a = 0.05 (Pearson's analysis, one of the parameters of disease progression.

  8. Leucócitos totais em cães com gastroenterite hemorrágica tratados por autohemoterapia

    Directory of Open Access Journals (Sweden)

    Rallyson Ramon Fernando Barbosa Lopes

    2017-05-01

    Full Text Available A gastroenterite hemorrágica (GEH é comum em cães jovens com sinais clínicos característicos como vômitos e diarreia. Entre as principais causas desse tipo de enfermidade estão as viroses como parvovirose e cinomose. O tratamento de GEH geralmente é sintomático com índice de recuperação em torno de 70%. A autohemoterapia é uma técnica em que se utiliza a administração de sangue autólogo por via intramuscular, a fim de estimular o sistema imunológico. Com o objetivo de avaliar a resposta leucocitária em cães acometidos de GEH e tratados com auto-hemoterapia foram utilizados 23 cães, divididos em dois grupos. No primeiro grupo (11 animais, foi realizada esta técnica em associação com o tratamento sintomático. No segundo grupo (12 animais, foi feito apenas o tratamento sintomático. Os animais foram avaliados por meio de hemograma e taxa de sobrevivência. Concluiu-se que a auto-hemoterapia não influenciou na recuperação dos animais. No entanto, produziu intensa leucocitose, efeito que pode ser investigado com maior amostragem de animais e em situações diversas.

  9. Avaliação do cuidado prestado a pacientes diabéticos em nível primário

    Directory of Open Access Journals (Sweden)

    Araújo Rejane B.

    1999-01-01

    Full Text Available OBJETIVO: Descrever características de pacientes diabéticos acompanhados em um posto de atenção primária à saúde. MÉTODOS: Estudo transversal. Rastrearam-se 3.024 prontuários de família, em busca de pacientes com 30-75 anos, com diagnóstico de diabetes, atendidos nos últimos cinco anos. Os pacientes detectados foram entrevistados em seus domicílios, e compareceram ao posto para o exame físico e requisição para dosagem da hemoglobina glicosilada. RESULTADOS: A prevalência de diabetes foi de 4,2%. A maioria eram mulheres brancas, ±50 anos de idade, com renda familiar mensal <= 3 salários-mínimos. Menos de um terço seguia dieta; e, apenas um quinto fazia exercícios regulares. Cerca de 70% estavam em uso de hipoglicemiantes orais ou insulina. Dos que fizeram o exame (adesão de 70%, a maioria apresentou níveis normais ou aceitáveis de glicemia. CONCLUSÕES: Maior esforço deve ser dispendido pelas equipes de saúde de forma a promover a adesão dos pacientes diabéticos à dieta e ao exercício.

  10. The thickness of the A1 pulleys reflects the disability of hand mobility in scleroderma. A pilot study using high-frequency ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Tagliafico, Alberto, E-mail: atagliafico@sirm.org [Department of Radiology, National Institute for Cancer Research, Genova (Italy); Panico, Nicoletta [Division of Immunology, Department of Internal Medicine, University of Genova, Genova (Italy); Serafini, Giovanni [Department of Radiology, Santa Corona Hospital, Pietra Ligure (Italy); Ghio, Massimo [Division of Immunology, Department of Internal Medicine, University of Genova, Genova (Italy); Martinoli, Carlo [Department of Radiology, University of Genova, Genova (Italy)

    2011-02-15

    Background: Hand involvement in scleroderma is a serious concern. Clinical tests to asses hand dysfunction are based on the experience of the clinician. Objective: To asses if utrasonographic (US) measurement of A1 pulley thickness may be used as an indicator of hand mobility in scleroderma. Materials and methods: Institutional review board approval and patient informed consent was obtained. Twenty-eight patients affected suffering from scleroderma and 40 healthy controls were prospectively evaluated by two blinded radiologists with US, with a transducer operating at 17 MHz. A1 pulley thickness was measured and correlated with the Hand Mobility in Scleroderma Test (HAMIS) and disease duration. Results: The thickness of the A1 pulley was greater in sclerodermic patients than in controls (p < 0.05). Intra and inter-observer agreement were better for ultrasound (0.94;0.88) than for HAMIS tests (0.71;0.70). A good correlation between pulley thickness, hand mobility and disease duration was found (r = 0.78, p < 0.018; r = 0.54, p < 0.05). Conclusion: A1 pulley thickness measured on ultrasound correlates with hand mobility and disease duration. Ultrasound is an useful tool to evaluate hand disability in scleroderma.

  11. A 200 MHz 35 MW Multiple Beam Klystron for Accelerator Applications. Final Report

    International Nuclear Information System (INIS)

    Ives, R. Lawrence; Read, Michael; Ferguson, Patrick; Marsden, David

    2011-01-01

    Calabazas Creek Research, Inc. (CCR) performed initial development of a compact and reliable 35 MW, multiple beam klystron (MBK) at 200 MHz with a pulse length of 0.125 ms and a 30 Hz repetition rate. The device was targeted for acceleration and ionization cooling of a muon collider, but there are several other potential applications in this frequency range. The klystron uses multiple beams propagating in individual beam tunnels to reduce space charge and allow reduction in the accelerating voltage. This allows a significant reduction in length over a single beam source. More importantly this allows more efficient and less expensive power supplies. At 200 MHz, the interaction circuit for a single beam klystron would be more than six meters long to obtain 50% efficiency and 50 dB gain. This would require a beam voltage of approximately 400 kV and current of 251 A for a microperveance of 1.0. For an eight beam MBK with the same beam perveance, a three meter long interaction circuit achieves the same power and gain. Each beam operates at 142 kV and 70A. The Phase I demonstrated that this device could be fabricated with funding available in a Phase II program and could achieve the program specifications.

  12. Celulitis por citomegalovirus

    Directory of Open Access Journals (Sweden)

    A. Ruiz Lascano

    2002-12-01

    Full Text Available Las lesiones cutáneas por citomegalovirus (CMV son infrecuentes y a menudo una manifestación tardía de una enfermedad sistémica, que generalmente anuncia un curso fatal. Comunicamos un caso de celulitis por CMV: una mujer de 70 años con trasplante renal efectuado 1 mes antes de la consulta, terapia inmunosupresora con ciclosporina A y metilprednisona. La paciente ingresó por fiebre, dolor e impotencia funcional en pierna derecha. Comprobamos la existencia de una placa de 8 por 4 cm eritematoedematosa. La tratamos con antibióticos sin mejoría, por lo que realizamos un estudio histopatológico de piel que mostró cambios citopáticos compatibles con infección por CMV. Los cultivos bacteriológicos y micológicos fueron negativos. La inmunohistoquímica específica para CMV y el estudio de reacción en cadena de la polimerasa (PCR de la biopsia de piel fueron positivas, al igual que la antigenemia. El tratamiento con ganciclovir produjo la mejoría del cuadro clínico. En la literatura revisada no hemos encontrado la celulitis como manifestación de enfermedad cutánea por CMV.

  13. de Uberaba, Minas Gerais

    Directory of Open Access Journals (Sweden)

    Darlene Mara dos Santos Tavares

    2008-01-01

    Full Text Available Este estudio, del tipo investigación domiciliaria, tiene como objetivo comparar las condiciones de salud de las personas mayores con diabetes mellitus de acuerdo a las variables sexo y área de edad. Participaron del estudio 417 ancianos, entrevistado en su casa, en el período comprendido entre diciembre de 2005 a febrero de 2006. Los datos fueron analizados a través de frecuencia simple y del teste qui-cuadrado (p < 0,05. La mayoría de los ancianos tenían un 60 a 70 años (50,1%, es la mujer (71,2% e hicieron uso de medicamentos (96,1%. Los principales problemas de salud fueron la hipertensión (75,5%, los problemas de visión (73,6% y la columna (56,4%. Las mujeres consideran la salud mala o muy mala y refieren el costo de medicamentos como un problema para su compra, en comparación con los hombres, diferencia estadísticamente significativa. Como ascendió a la edad, encontró mayor proporción de ancianos que utilizan los equipos, problemas de columna y que utilizan diuréticos.

  14. A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo.

    Science.gov (United States)

    Zhang, Shi-Jie; Li, Yi-Fang; Tan, Rui-Rong; Tsoi, Bun; Huang, Wen-Shan; Huang, Yi-Hua; Tang, Xiao-Long; Hu, Dan; Yao, Nan; Yang, Xuesong; Kurihara, Hiroshi; Wang, Qi; He, Rong-Rong

    2016-02-01

    Gestational diabetes mellitus (GDM) is one of the leading causes of fetal malformations. However, few models have been developed to study the underlying mechanisms of GDM-induced fetal eye malformation. In this study, a high concentration of glucose (0.2 mmol per egg) was injected into the air sac of chick embryos on embryo development day (EDD) 1 to develop a hyperglycemia model. Results showed that 47.3% of embryonic eye malformation happened on EDD 5. In this model, the key genes regulating eye development, Pax6, Six3 and Otx2, were downregulated by hyperglycemia. Among these genes, the expression of Pax6 was the most vulnerable to hyperglycemia, being suppressed by 70%. A reduction in Pax6 gene expression induced eye malformation in chick embryos. However, increased expression of Pax6 in chick embryos could rescue hyperglycemia-induced eye malformation. Hyperglycemia stimulated O-linked N-acetylglucosaminylation, which caused oxidative stress in chick embryos. Pax6 was found to be vulnerable to free radicals, but the antioxidant edaravone could restore Pax6 expression and reverse eye malformation. These results illustrated a successful establishment of a new chick embryo model to study the molecular mechanism of hyperglycemia-induced eye malformation. The suppression of the Pax6 gene is probably mediated by oxidative stress and could be a crucial target for the therapy of GDM-induced embryonic eye malformation. © 2016. Published by The Company of Biologists Ltd.

  15. Odontogenic tumors: analysis of 127 cases Tumores odontogênicos: análise de 127 casos

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    Jean Nunes SANTOS

    2001-12-01

    Full Text Available One hundred and twenty-seven cases of histologically confirmed odontogenic tumors were retrieved from a total of 5,289 oral and maxillary lesions diagnosed at the Division of Oral Pathology, Federal University of Rio Grande do Norte, during a period of 30 years (l970-l999. The most common histological diagnosis was odontoma (50.40%, followed by ameloblastoma (30.70%. The prevalence of odontogenic tumors was greater in females and the peak incidence occurred in the second and third decades of life. The main anatomical location was the mandible, and no malignant tumors were found.De uma série de 5.289 casos de lesões orais e dos maxilares diagnosticadas no Laboratório de Patologia Oral da Faculdade de Odontologia da Universidade Federal do Rio Grande do Norte no período de 30 anos (1970-1999, foram analisados 127 casos de tumores odontogênicos confirmados histologicamente. A lesão mais freqüente foi o odontoma (50,40% seguida pelo ameloblastoma (30,70%. A prevalência de tumores odontogênicos foi maior nas mulheres e o pico de incidência ocorreu na segunda e terceira décadas de vida. A localização anatômica mais comum foi a mandíbula e não foram encontrados casos de tumores malignos.

  16. Efectos de un Programa de Rehabilitación Cardiaca Fase I en Pacientes Revascularizados

    Directory of Open Access Journals (Sweden)

    Lilian Barros Higgins

    2014-07-01

    Introduction: Cardiovascular diseases are one of the leading causes of death worldwide. I show programs phase I cardiac rehabilitation have been evolving and is considered as one of the first strategies used to decrease the risk of recurrence of a coronary event. Objective: To describe the effectiveness of phase I cardiac rehabilitation in a group of pre postsurgical patients and myocardial revascularization. Methods: Quasi-experimental study. Was applied to the scale of Borg and walk 6 minutes to 10 patients pre and post-operative myocardial revascularization in cardiac rehabilitation program in clinical phase I of the coast. Data were analyzed in SPSS. Results: Hypertension is the most frequent pathology with 80 % of the study population 70 % had a moderate cardiovascular risk ; the risk factor was predominant physical inactivity with 70 % a significant difference according to the predicted Troosther of 405 meters was found, driven compared to the first evaluation likewise at the beginning of the program as the Borg scale was perceived exertion 5.5 points or after completing an average of 1.8 points , corresponding to a soft effort was obtained. Conclusion: based on the results , the clinical impact of the following study was to demonstrate the implementation of phase 1 of the cardiac rehabilitation programs for patients undergoing this study improved functional capacity and exercise tolerance.

  17. Small Angle Neutron Scattering (SANS) characterization of electrically conducting polyaniline nanofiber/polyimide nanocomposites

    Energy Technology Data Exchange (ETDEWEB)

    Hopkins, Alan R., E-mail: alan.r.hopkins@aero.org [Aerospace Corporation, Space Materials Lab, Micro/Nano Technology Dept, Polymers Section, M2/242, Los Angeles, CA 90009-2957 (United States); Tomczak, Sandra J. [AFRL/RZSM Materials Application Branch, Space and Missile Propulsion Division 10 East Saturn Blvd., Bldg. 8451, Edwards Air Force Base, CA 93524 (United States); Vij, Vandana [ERC. Inc., AFRL/PRSM, Edwards AFB, CA (United States); Jackson, Andrew J. [National Institute of Standards and Technology (NIST) Center for Neutron Research, 100 Bureau Drive, Stop 6102, Gaithersburg, MD 20899-6102 (United States)

    2011-12-30

    Nanocomposites of polyaniline nanofibers and polyimide were fabricated and studied using small angle neutron scattering (SANS). The immiscible nature of the conformationally dissimilar polyaniline nanofiber and polyimide host is established by a series of experiments involving neutron scattering. Based on these techniques, we conclude that the crystal structure of the polyimides is not disrupted, and that there is no mixing between the two components on a molecular level. The morphology of the conducting salt component was analyzed by SANS data and was treated by two common models: Debye-Bueche (D-B) and inverse power law (IPL). Due to deviations in the linear curve fitting over a large scattering range, neither the D-B nor the IPL model could be used to characterize the size and shape of all PANI-0.5-CSA (polyaniline camphor sulfonic acid doped polymer)/polyimide blend systems. At 1 and 2% concentration, the D-B model suggested salt domains between 20 and 70 A with fractal geometries implied by the IPL model. As salt concentrations increased to 5%, the structures were observed to change, but there is no simple structural model that provides a suitable basis for comparison.

  18. “SANTAS CRUZES” LOCUS DE NUCLEAÇÃO DE RESTAURAÇÃO AMBIENTAL. METODOLOGIA POR ABANDONO E REGENERAÇÃO ESPONTÂNEA, UM RISCO PARA O BIOMA MATA ATLÂNTICA

    Directory of Open Access Journals (Sweden)

    Cristiane da Silva Jacob

    2017-04-01

    Full Text Available Uma expressão cultural-religiosa “Santa Cruz” (altar com descarte de imagens de valor sacro para a Igreja Católica tem possível valor deletério sobre o Hotspot ambiental Mata Atlântica, na região Metropolitana do Vale do Paraíba e Litoral Norte Paulista. Material e Métodos: foi construído um modelo de Santa Cruz similar às encontradas na Mata Atlântica e, durante seis meses (outono/inverno foram medidas as alterações de pH do solo e a retenção de água, pós chuva e em período de seca, pelas imagens de gesso. Os resultados mostraram que nesses lócus o pH do solo oscilou entre 6,3 e 7,0; a umidade retida nas peças de gesso aumentou a massa das imagens em ambos os períodos.Concluiu-se que estas Santas Cruzes podem se transformar em ambientes semelhantes ao modelo de nucleação por abandono usado para a recomposição florestal de áreas degradados, mas também permite o desenvolvimento de Espécies Invasoras ao Bioma, oferecendo riscos antrópicos ao Hotspot.

  19. Los procesos constructivos de la arquitectura clásica. De la proyección a la ejecución. El caso del Concilium Provinciae Hispaniae Citerioris de Tarraco

    Directory of Open Access Journals (Sweden)

    Puche Fontanilles, Josep M.

    2010-12-01

    Full Text Available Any architectural work requires a previous projection involving the definition and justification of its forms and proportions. This projection is often modified by an existing reality or, in cases of long constructive periods, by changes of opinion, aim or, even, promoter. This is the case of the Concilium Provinciae Hispaniae Citerioris, a monumental complex, more than 12 hectares large, which was likely built in 70-75 years. The archaeological remains allow identifying two successive architectural projects which involve a major change while the building is in progress.Toda obra arquitectónica necesita de una proyección previa que implique la definición y justificación de sus formas y proporciones, proyección que, a menudo, viene modificada por la realidad ya existente o, en casos de periodos constructivos largos por cambios de opinión, de finalidad o, incluso de promotor. Es el caso del Concilium Provinciae Hispaniae Citerioris de Tarraco, un gran complejo monumental de más de 12 hectáreas de extensión, que necesitó un periodo de tiempo de construcción de entre 70 a 75 años. Los restos arqueológicos conservados permiten la identificación de dos proyectos arquitectónicos sobrepuestos que implican un profundo cambio de proyecto durante el proceso constructivo.

  20. Cryptogenic organizing pneumonia-Results of treatment with clarithromycin versus corticosteroids-Observational study.

    Directory of Open Access Journals (Sweden)

    Elżbieta Radzikowska

    Full Text Available Cryptogenic organizing pneumonia (COP is a clinicopathological syndrome of unknown origin. Corticosteroids are the standard treatment, but clarithromycin (CAM is also effective. The aim of this observational retrospective study was to compare the results of CAM versus prednisone (PRE treatment in patients with biopsy-proven OP without respiratory insufficiency.In a 15-year period, 40 patients were treated with CAM (500 mg twice daily orally for 3 months and 22 with PRE (mean initial dose of 0.67 ± 0.24 mg/kg/d for a mean of 8.59 ± 3.05 months.The clinical presentation, laboratory, and radiological findings did not differ markedly between patients treated with CAM and PRE, with the exception of a higher frequency of sweats (55% vs. 23%; p 80% identified patients who might be successfully treated with CAM with a sensitivity of 60% and a specificity of 88.57% (AUC 0.869; 95% CI 0.684-1; p = 0.008; the figures for the FEV1 were >70%, a sensitivity of 60%, and a specificity of 91.43% (AUC 0.809; 95%CI 0.609-1; p = 0.027.CAM can be used to treat COP patients in whom the pulmonary function parameters are within normal limits. Such therapy is shorter, better tolerated, and associated with fewer adverse events and relapses than is PRE. However, the therapy is ineffective in some patients.

  1. Can opium abuse be a risk factor for carotid stenosis in patients who are candidates for coronary artery bypass grafting?

    Science.gov (United States)

    Shirani, Shapour; Shakiba, Madjid; Soleymanzadeh, Maryam; Esfandbod, Maryam

    2010-01-01

    Over the centuries, opium has been the most frequent substance abused in the Middle East. There are many controversial aspects about the effects of opioids on the atherosclerosis process, which is still unclear. All patients who were candidates for coronary artery bypass graft in Tehran Heart Center were registered and evaluated for risk factors such as diabetes mellitus, hypertension, smoking status and duration, opium abuse, involved coronary arteries and left main branch lesion > 50%, carotid stenosis > or = 70%. A total of 1,339 patients were enrolled in the study, of whom 400 (29.9%) were female and the other 939 (70.1%) male. Female patients were omitted from analysis due to the low numbers of female opium addicts. Our study revealed that in the addicted population, the risk of diabetes and hypertension was lower than in the non-addicted group (p 50% and extent of carotid stenosis was not significantly different between the two groups. Our investigations demonstrate that opium is not cardioprotective, as has been claimed by some previous studies, and does not even decelerate atherosclerosis of carotid arteries in opium-addicted patients, but more evidence is still needed to completely prove the case.

  2. The Recent Infection Testing Algorithm (RITA) in clinical practice: a survey of HIV clinicians in England and Northern Ireland.

    Science.gov (United States)

    Garrett, Nj; Lattimore, S; Gilbart, Vl; Aghaizu, A; Mensah, G; Tosswill, J; Murphy, G; Delpech, V

    2012-08-01

    In order to estimate HIV incidence among high-risk groups, in January 2009 the Health Protection Agency introduced the Recent Infection Testing Algorithm (RITA) in England and Northern Ireland (E&NI), currently the only regions to inform patients of RITA results. This survey of HIV specialists aimed to investigate the role of RITA in patient management and explore clinicians' views on its role in clinical practice and during partner notification. An online questionnaire was distributed to HIV specialists via the British HIV Association membership email list in February 2011. Forty-two HIV specialists from 32 HIV centres responded to the survey among 90 centres enrolled in the programme (response rate 36%). Testing for recent infection was considered standard of care by 83% of respondents, 80% felt confident in interpreting results and 92% discussed results with patients, particularly in the context of a possible HIV seroconversion illness (96%) or when deciding when to start antiretroviral therapy (70%). A third (36%) of specialists were initially concerned that RITA results may cause additional anxiety among patients; however, no adverse events were reported. The majority (90%) felt that results could assist with contact tracing by prioritizing patients with likely recent infection. However, only a few centres have currently incorporated RITA into their HIV partner notification protocols. RITA has been introduced into clinical practice with no reported patient adverse events. Access to results at centre level should be improved. National guidance regarding use of RITA as a tool for contact tracing is required. © 2012 British HIV Association.

  3. Soymilk plain beverages: correlation between acceptability and physical and chemical characteristics

    Directory of Open Access Journals (Sweden)

    Marcela Moreira Terhaag

    2013-06-01

    Full Text Available The objective of the research was to relate the physical and chemical characteristics of soymilk plain beverages to its sensory acceptance. Five commercial products and a new product formulated based on the less accepted sample were used. The overall acceptance was evaluated by 102 assessors using a 10-point hybrid hedonic scale. The hedonic scores ranged from 3.8 (sample E to 7.0 (A. Most assessors (55% preferred sample A, which was viscous (26.6 cp, dark (L* = 77.7, and slightly acidic (pH = 6.6. Sample C, which had lower solid content and higher acidity, was preferred by 29% of the assessors. These two beverages showed the greatest commercial potential of the products analyzed. The least-accepted sample (E, preferred by 8% of the assessors, had a lighter color (L* = 96.8, lower viscosity (13.5 cp, higher lipid content (2.2 g/100 g, and less protein (1.68 g/100 g than the other products evaluated. A reformulation of the least preferred product (E with the addition of maltodextrin and also vanilla and milk flavors increased its acceptance, yielding an average score of 7.2. Overall, it was observed that a soymilk plain beverage with higher viscosity, darker color, and higher protein content best meets consumer expectations.

  4. Effect of 3-Day Bed Rest on the Basal Sympathetic Activity and Responsiveness of this System to Physiological Stimuli In Athletes and Sedentary Subjects

    Science.gov (United States)

    Smorawinski, Jerzy; Adrian, Jacek; Kaciuba-Uscilko, Hanna; Nazar, Krystyna; Greenleaf, John E.; Dalton, P. Bonnie (Technical Monitor)

    2002-01-01

    The aims of this study were: (1) to examine the effect of three days of bed rest (BR) on basal plasma epinephrine [E] and norepinephrine [NE] and the catecholamine responses to various physiological stimuli, and (2) to find out whether previous physical activity modifies effects of BR. In the first series, 29 young men (11 sedentary students, 8 endurance and 10 strength trained athletes) were submitted to oral glucose tolerance test in supine position and to active orthostatic test before and after 3 days of BR. Plasma [E] and [NE] were measured after overnight fast (basal condition), at 60, 120 and 180 min after glucose ingestion (70 a), and at the 8th min of unsupported standing. In the second series, other 22 subjects (12 sedentary students, 10 endurance and 10 strength trained athletes) were submitted to 2 min cold pressor test (CPT) and exercise. Plasma E and NE were determined in the supine position after overnight fast and at 60th and 120th s of hand cooling. Then, after breakfast followed by 2-3 hour sitting, the subjects performed cycle ergometer exercise with workload increasing until volitional exhaustion. Plasma [E] and [NE] were determined at the end of each load. Plasma catecholamines were determined made radioenzymatically. After BR, basal plasma [NE] was decreased in endurance and strength athletes (psedentary subjects. In neither group BR affected the basal [E]. Responses of both catecholamines to glucose load were diminished after BR in all three groups (pwork intensity after than before BR (p<0.05).

  5. Dry etching of MgCaO gate dielectric and passivation layers on GaN

    International Nuclear Information System (INIS)

    Hlad, M.; Voss, L.; Gila, B.P.; Abernathy, C.R.; Pearton, S.J.; Ren, F.

    2006-01-01

    MgCaO films grown by rf plasma-assisted molecular beam epitaxy and capped with Sc 2 O 3 are promising candidates as surface passivation layers and gate dielectrics on GaN-based high electron mobility transistors (HEMTs) and metal-oxide semiconductor HEMTs (MOS-HEMTs), respectively. Two different plasma chemistries were examined for etching these thin films on GaN. Inductively coupled plasmas of CH 4 /H 2 /Ar produced etch rates only in the range 20-70 A/min, comparable to the Ar sputter rates under the same conditions. Similarly slow MgCaO etch rates (∼100 A/min) were obtained with Cl 2 /Ar discharges under the same conditions, but GaN showed rates almost an order of magnitude higher. The MgCaO removal rates are limited by the low volatilities of the respective etch products. The CH 4 /H 2 /Ar plasma chemistry produced a selectivity of around 2 for etching the MgCaO with respect to GaN

  6. Regulation of amyloid precursor protein processing by its KFERQ motif.

    Science.gov (United States)

    Park, Ji-Seon; Kim, Dong-Hou; Yoon, Seung-Yong

    2016-06-01

    Understanding of trafficking, processing, and degradation mechanisms of amyloid precursor protein (APP) is important because APP can be processed to produce β-amyloid (Aβ), a key pathogenic molecule in Alzheimer's disease (AD). Here, we found that APP contains KFERQ motif at its C-terminus, a consensus sequence for chaperone-mediated autophagy (CMA) or microautophagy which are another types of autophagy for degradation of pathogenic molecules in neurodegenerative diseases. Deletion of KFERQ in APP increased C-terminal fragments (CTFs) and secreted N-terminal fragments of APP and kept it away from lysosomes. KFERQ deletion did not abolish the interaction of APP or its cleaved products with heat shock cognate protein 70 (Hsc70), a protein necessary for CMA or microautophagy. These findings suggest that KFERQ motif is important for normal processing and degradation of APP to preclude the accumulation of APP-CTFs although it may not be important for CMA or microautophagy. [BMB Reports 2016; 49(6): 337-342].

  7. Evaluation of stroke volume variation obtained by arterial pulse contour analysis to predict fluid responsiveness intraoperatively.

    Science.gov (United States)

    Lahner, D; Kabon, B; Marschalek, C; Chiari, A; Pestel, G; Kaider, A; Fleischmann, E; Hetz, H

    2009-09-01

    Fluid management guided by oesophageal Doppler monitor has been reported to improve perioperative outcome. Stroke volume variation (SVV) is considered a reliable clinical predictor of fluid responsiveness. Consequently, the aim of the present trial was to evaluate the accuracy of SVV determined by arterial pulse contour (APCO) analysis, using the FloTrac/Vigileo system, to predict fluid responsiveness as measured by the oesophageal Doppler. Patients undergoing major abdominal surgery received intraoperative fluid management guided by oesophageal Doppler monitoring. Fluid boluses of 250 ml each were administered in case of a decrease in corrected flow time (FTc) to 10%. The ability of SVV to predict fluid responsiveness was assessed by calculation of the area under the receiver operating characteristic (ROC) curve. Twenty patients received 67 fluid boluses. Fifty-two of the 67 fluid boluses administered resulted in fluid responsiveness. SVV achieved an area under the ROC curve of 0.512 [confidence interval (CI) 0.32-0.70]. A cut-off point for fluid responsiveness was found for SVV > or =8.5% (sensitivity: 77%; specificity: 43%; positive predictive value: 84%; and negative predictive value: 33%). This prospective, interventional observer-blinded study demonstrates that SVV obtained by APCO, using the FloTrac/Vigileo system, is not a reliable predictor of fluid responsiveness in the setting of major abdominal surgery.

  8. Evaluación de la prueba ICT Malaria P. f/P.v ( AMRAD ® para la detección de P. falciparum y P. vivax en una zona endémica de la Amazonía peruana

    Directory of Open Access Journals (Sweden)

    Fernando Llanos-Zavalaga

    2002-01-01

    Full Text Available Objetivo: Evaluar el rendimiento del ICT MALARIA P.f/P.v (AMRAD® en pacientes febriles del departamento de Loreto, Perú. Materiales y métodos: estudio transversal realizado de agosto a setiembre del 2000, en pacientes con historia de fiebre (temperatura axilar 37,5°C en los últimos 3 días, sin un foco aparente. Se obtuvo una muestra de sangre para gota gruesa cuya lectura se realizó por un microscopista experto. Simultáneamente, se realizó la prueba rápida por un asistente de campo. Se calculó la sensibilidad, especificidad, valores predictivos, exactitud e índice de concordancia utilizando la gota gruesa como prueba de oro. Resultados: se incluyeron 79 pacientes de 5 meses - 70 años de edad. La sensibilidad y especificidad del AMRAD ® fueron 60,0% y 70,0%, respectivamente. El valor predictivo positivo (VPP, valor predictivo negativo (VPN y exactitud de la prueba fueron 36,0%, 88,8% y 70,9%, respectivamente. Se encontró pobre concordancia de la prueba con la gota gruesa (kappa=0,279. Conclusión: es necesario continuar con la evaluación de las pruebas rápidas para un diagnóstico oportuno y un tratamiento efectivo de la malaria.

  9. Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network.

    Science.gov (United States)

    Keegan, Caroline; Krutzik, Stephan; Schenk, Mirjam; Scumpia, Philip O; Lu, Jing; Pang, Yan Ling Joy; Russell, Brandon S; Lim, Kok Seong; Shell, Scarlet; Prestwich, Erin; Su, Dan; Elashoff, David; Hershberg, Robert M; Bloom, Barry R; Belisle, John T; Fortune, Sarah; Dedon, Peter C; Pellegrini, Matteo; Modlin, Robert L

    2018-05-01

    Upon recognition of a microbial pathogen, the innate and adaptive immune systems are linked to generate a cell-mediated immune response against the foreign invader. The culture filtrate of Mycobacterium tuberculosis contains ligands, such as M. tuberculosis tRNA, that activate the innate immune response and secreted Ags recognized by T cells to drive adaptive immune responses. In this study, bioinformatics analysis of gene-expression profiles derived from human PBMCs treated with distinct microbial ligands identified a mycobacterial tRNA-induced innate immune network resulting in the robust production of IL-12p70, a cytokine required to instruct an adaptive Th1 response for host defense against intracellular bacteria. As validated by functional studies, this pathway contained a feed-forward loop, whereby the early production of IL-18, type I IFNs, and IL-12p70 primed NK cells to respond to IL-18 and produce IFN-γ, enhancing further production of IL-12p70. Mechanistically, tRNA activates TLR3 and TLR8, and this synergistic induction of IL-12p70 was recapitulated by the addition of a specific TLR8 agonist with a TLR3 ligand to PBMCs. These data indicate that M. tuberculosis tRNA activates a gene network involving the integration of multiple innate signals, including types I and II IFNs, as well as distinct cell types to induce IL-12p70. Copyright © 2018 by The American Association of Immunologists, Inc.

  10. Using sewage sludge pyrolytic gas to modify titanium alloy to obtain high-performance anodes in bio-electrochemical systems

    Science.gov (United States)

    Gu, Yuan; Ying, Kang; Shen, Dongsheng; Huang, Lijie; Ying, Xianbin; Huang, Haoqian; Cheng, Kun; Chen, Jiazheng; Zhou, Yuyang; Chen, Ting; Feng, Huajun

    2017-12-01

    Titanium is under consideration as a potential stable bio-anode because of its high conductivity, suitable mechanical properties, and electrochemical inertness in the operating potential window of bio-electrochemical systems; however, its application is limited by its poor electron-transfer capacity with electroactive bacteria and weak ability to form biofilms on its hydrophobic surface. This study reports an effective and low-cost way to convert a hydrophobic titanium alloy surface into a hydrophilic surface that can be used as a bio-electrode with higher electron-transfer rates. Pyrolytic gas of sewage sludge is used to modify the titanium alloy. The current generation, anodic biofilm formation surface, and hydrophobicity are systematically investigated by comparing bare electrodes with three modified electrodes. Maximum current density (15.80 A/m2), achieved using a modified electrode, is 316-fold higher than that of the bare titanium alloy electrode (0.05 A/m2) and that achieved by titanium alloy electrodes modified by other methods (12.70 A/m2). The pyrolytic gas-modified titanium alloy electrode can be used as a high-performance and scalable bio-anode for bio-electrochemical systems because of its high electron-transfer rates, hydrophilic nature, and ability to achieve high current density.

  11. METODOLOGÍA CIENTÍFICA EN VALORACIÓN Y SELECCIÓN AMBIENTAL

    Directory of Open Access Journals (Sweden)

    Moreno Jiménez José María

    2001-01-01

    Full Text Available El paradigma de la racionalidad sustantiva ha dominado la investigación científica durante la mayor parte del siglo XX. No obstante, cuando se trabaja con aspectos intangibles y múltiples criterios, como sucede en valoración y selección ambiental, esta filosofía positivista orientada a la predicción y el control presenta serias limitaciones, lo que ha llevado desde comienzo de los 70 a la búsqueda de nuevas aproximaciones. El constructivismo y la ciencia postnormal son algunas de las más extendidas en el campo de la economía ecológica. En lo que sigue, se analiza su relación con una de las aproximaciones más recientes en este ámbito: la racionalidad procedimental multicriterio, intentando establecer un marco para la metodología científica en selección ambiental.

  12. Análisis del volumen de entrenamiento pliométrico para la mejora del salto

    Directory of Open Access Journals (Sweden)

    Rafael Copoví Lanusse

    2015-06-01

    Full Text Available El objetivo de este estudio fue determinar el efecto de diferentes volúmenes de entrenamiento sobre la mejora del salto vertical. Método: se realizó una búsqueda de información en las bases de datos PubMed, MedLine y SportsDiscus donde se identificaron 59 artículos que cumplían los siguientes criterios: a Estudios que incluyan programas de entrenamiento pliométrico de miembros inferiores, b Que contengan programas experimentales y medidas válidas y seguras. Aquellos programas con un volumen de entrenamiento de 8 a 12 semanas con una frecuencia de 2 a 3 sesiones semanales, en las cuales se realizan de 1 a 3 ejercicios con un total de 3 a 8 series por sesión y en las que se den una media de 70 a 100 saltos, parece ser la mejor combinación.

  13. Gallium tomoscintigraphic imaging of esophageal cancer using emission computed tomography

    International Nuclear Information System (INIS)

    Hattori, Takao; Nakagawa, Tsuyoshi; Takeda, Kan; Maeda, Hisato; Taguchi, Mitsuo

    1983-01-01

    Emission computed tomography (ECT) was clinically evaluated in 67 Ga imaging of esophageal cancer. ECT system used in this study is equipped with opposed dual large-field-of-view cameras (GCA 70A-S, Toshiba Co.). Data were acquired by rotating the two cameras 180 0 about the longitudinal axis of the patient. Total acquisition time was about 12 minutes. Multiple slices of transaxial, sagittal and coronal sections were reconstructed in a 64 x 64 matrix form using convolution algorithms. In three out of six cases studied the tumor uptake was not detected on conventional images, because the lesion was small, concentration of activity was poor or the lesion activity was overlapped with the neighbouring activities distributed to normal organs such as sternum, vertebra, liver and hilus. On ECT images, by contrast, abnormal uptake of the tumors was definitively detected in all the six cases. ECT imaging was also useful in estimating the effect of treatment by the decrease in 67 Ga concentration. We have devised a special technique to repeat ECT scan with a thin tube filled with 67 Ga solution inserted through the esophagus. By this technique, comparing paired images with and without the tube activity, exact location of the uptake against the esophagus and extraesophageal extension of the disease could be accurately evaluated in a three-dimensional field of view. ECT in gallium scanning is expected to be of great clinical value to elevate the confidence level of diagnosis in detecting, localizing and following up the diseases. (author)

  14. Investigation of endurance limit- and low-cycle fatigue strength of St E 47 and STE 70 in the welded and unwelded state

    International Nuclear Information System (INIS)

    Jaenicke, B.; Helms, R.; Florian, W.; Lipp, H.J.; Seidl, W.; Kaiser, B.

    1979-01-01

    To clarify clear the effect of the welding conditions and the heat treatment, alternating load tests were carried out in the endurance limit- and low-cycle-fatigue strength range on specimens of St E 47 and St E 70. Grounded basic material flat specimens cleared from their rolling skins and welded flat specimens with a butt weld of special quality were used. The welds were produced by the metal arc manual welding method with bar electrodes (low heat introduction) and with the submerged-arc welding method (high heat introduction). Part of the specimens were tempered free from stress after welding. The tests were carried out force-controlled at tension-repeated loading (S=0) and strain controlled at tension-compression alternating loading (S approx. -1). In the range of N = 5 x 10 4 ...1,5 x 10 6 cycles a small effect of the welding (special quality) for St E 47 with subsequence tempering on the endurance limit was proofed, which in comparison with the unwelded basic material (grounded surface) was characterized by broad range at nearly the same endurance limit. For St E 70, a clear decrease of the endurance limit of welded, tempered specimens (special quality) was found as compared with the basic material (grounded surface). (orig./RW) 891 RW/orig.- 892 RKD [de

  15. Glycosaminoglycan interactions in murine gammaherpesvirus-68 infection.

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    Laurent Gillet

    2007-04-01

    Full Text Available Glycosaminoglycans (GAGs commonly participate in herpesvirus entry. They are thought to provide a reversible attachment to cells that promotes subsequent receptor binding. Murine gamma-herpesvirus-68 (MHV-68 infection of fibroblasts and epithelial cells is highly GAG-dependent. This is a function of the viral gp150, in that gp150-deficient mutants are much less GAG-dependent than wild-type. Here we show that the major MHV-68 GAG-binding protein is not gp150 but gp70, a product of ORF4. Surprisingly, ORF4-deficient MHV-68 showed normal cell binding and was more sensitive than wild-type to inhibition by soluble heparin rather than less. Thus, the most obvious viral GAG interaction made little direct contribution to infection. Indeed, a large fraction of the virion gp70 had its GAG-binding domain removed by post-translational cleavage. ORF4 may therefore act mainly to absorb soluble GAGs and prevent them from engaging gp150 prematurely. In contrast to gp70, gp150 bound poorly to GAGs, implying that it provides little in the way of adhesion. We hypothesize that it acts instead as a GAG-sensitive switch that selectively activates MHV-68 entry at cell surfaces.

  16. Sotos syndrome (cerebral gigantism): a clinical and radiological study of 14 cases from Saudi Arabia.

    Science.gov (United States)

    al Rashed, A A; al-Jarallah, A A; Salih, M A; Kolawole, T; al-Jarallah, J

    1999-06-01

    Fourteen children (of Arab ethnic origin) with Sotos syndrome are described. They were referred to King Khalid University Hospital, Riyadh between July 1992 and June 1997. Their phenotypic characteristics were compared with established diagnostic criteria. There was a male:female ratio of 1.3:1 and a high rate of consanguinity (36%) among parents. At birth, 54% were large and about one-third showed increased height and occipitofrontal head circumference (OFHC). The neonatal histories revealed respiratory and feeding problems in 21%, followed later by delayed motor milestones and speech development in 57%. During childhood, weight, height and OFHC increased further to > 97th centile in 71%, 71% and 93%, respectively. A seizure disorder affected 43%, and 75% had mental retardation (IQ < 70). A non-specific EEG abnormality was found in half of those with seizures. Cranial CT/MRI showed ventricular dilatation in 15% and one patient had corpus callosum dysgenesis. Abdominal ultrasound revealed hydronephrosis in two patients. Radiological cephalometric measurements showed relative prognathism in cases of Sotos syndrome compared with controls (p = 0.003). The study highlights the importance of considering Sotos syndrome in children who present with psychomotor delay.

  17. Indicadores de desempenho zootécnico observados nas unidades de produção familiar associadas à Cooperativa dos Produtores de Leite de Santa Maria (COOPROL, RS

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    Portela Jorge Nunes

    2002-01-01

    Full Text Available O presente trabalho teve o objetivo de identificar o desempenho zootécnico das unidades de produção familiar (UPFs associadas à Cooperativa dos Produtores de Leite de Santa Maria (COOPROL, RS, que desenvolvem a atividade leiteira combinada ou não com outras atividades vegetal e/ou animal. Foram coletadas as informações de um grupo de 53 UPFs, sendo identificados nove sistemas de produção. Nestes sistemas, a idade média ao primeiro parto (IPP variou de 2,5 a 3 anos, o intervalo entre partos (IEP de 456 a 520 dias, o período seco (PS de 91 a 260 dias, a taxa de natalidade de 70 a 80%, a duração média das lactações (DML de 365 a 387 dias e a produtividade de leite de 2,52 a 13,5 /vaca/dia. Estes valores indicam a necessidade de ações visando readequar o manejo reprodutivo e o sistema alimentar dos rebanhos de cada sistema de produção identificado.

  18. Bax function in the absence of mitochondria in the primitive protozoan Giardia lamblia.

    Directory of Open Access Journals (Sweden)

    Adrian B Hehl

    Full Text Available Bax-induced permeabilization of the mitochondrial outer membrane and release of cytochrome c are key events in apoptosis. Although Bax can compromise mitochondria in primitive unicellular organisms that lack a classical apoptotic machinery, it is still unclear if Bax alone is sufficient for this, or whether additional mitochondrial components are required. The protozoan parasite Giardia lamblia is one of the earliest branching eukaryotes and harbors highly degenerated mitochondrial remnant organelles (mitosomes that lack a genome. Here we tested whether human Bax expressed in Giardia can be used to ablate mitosomes. We demonstrate that these organelles are neither targeted, nor compromised, by Bax. However, specialized compartments of the regulated secretory pathway are completely ablated by Bax. As a consequence, maturing cyst wall proteins that are sorted into these organelles are released into the cytoplasm, causing a developmental arrest and cell death. Interestingly, this ectopic cargo release is dependent on the carboxy-terminal 22 amino acids of Bax, and can be prevented by the Bax-inhibiting peptide Ku70. A C-terminally truncated Bax variant still localizes to secretory organelles, but is unable to permeabilize these membranes, uncoupling membrane targeting and cargo release. Even though mitosomes are too diverged to be recognized by Bax, off-target membrane permeabilization appears to be conserved and leads to cell death completely independently of mitochondria.

  19. Tungsten trioxide as high-{kappa} gate dielectric for highly transparent and temperature-stable zinc-oxide-based thin-film transistors

    Energy Technology Data Exchange (ETDEWEB)

    Lorenz, Michael; Wenckstern, Holger von; Grundmann, Marius [Universitaet Leipzig, Fakultaet fuer Physik und Geowissenschaften, Institut fuer Experimentelle Physik II, Linnestr. 5, 04103 Leipzig (Germany)

    2012-07-01

    We demonstrate metal-insulator-semiconductor field-effect transistors with high-{kappa}, room-temperature deposited, highly transparent tungsten trioxide (WO{sub 3}) as gate dielectric. The channel material consists of a zinc oxide (ZnO) thin-film. The transmittance and resistivity of WO{sub 3} films was tuned in order to obtain a highly transparent and insulating WO{sub 3} dielectric. The devices were processed by standard photolithography using lift-off technique. On top of the WO{sub 3} dielectric a highly transparent and conductive oxide consisting of ZnO: Al 3% wt. was deposited. The gate structure of the devices exhibits an average transmittance in the visible spectral range of 86%. The on/off-current ratio is larger than 10{sup 8} with off- and gate leakage-currents below 3 x 10{sup -8} A/cm{sup 2}. Due to the high relative permittivity of {epsilon}{sub r} {approx} 70, a gate voltage sweep of only 2 V is necessary to turn the transistor on and off with a minimum subthreshold swing of 80 mV/decade. The channel mobility of the transistors equals the Hall-effect mobility with a value of 5 cm{sup 2}/Vs. It is furthermore shown, that the devices are stable up to operating temperatures of at least 150 C.

  20. GENDER DIFFERENTIALS IN FACTORS AFFECTING PERFORMANCE OF SMALL-SCALE ENTERPRISES IN LAGOS STATE – NIGERIA

    Directory of Open Access Journals (Sweden)

    Yusuff Olabisi Sherifat

    2013-05-01

    Full Text Available There is a lack of empirical data segregation on factors affecting gender as the variable of interest. However, previous research had indicated several factors that affect business performances among small-scale enterprise owners. Using feminist theory and a descriptive survey research design, data were collected from fifty (50 small-scale enterprise owners that were purposively chosen across the study area. The findings show that the factors that were significant for female were significantly different from male. For female small scale enterprise owners, marital status (64% Age of Children (68%, Role Model/ advisors (58% were significant factors that affect their business performance. For male small-scale enterprise owners, Friends (70%, a lack of Government support (80%, inability to display innovativeness (78% and Risk-Taking (84% were significant for male. Lack of availability of capital and finances were significant for the two. Other factors that affect performance include friends, inadequate training and business location. Adequate knowledge of factors that affect gender enterprise performance will go a long way in alleviating these problems. Small-scale enterprises should be supported for poverty alleviation, especially among women and for the nation’s economic development

  1. Justifications and self-organization as determinants of recycling behavior. The case of used batteries

    Energy Technology Data Exchange (ETDEWEB)

    Hansmann, Ralf; Bernasconi, Petra; Smieszek, Timo; Loukopoulos, Peter; Scholz, Roland W [Chair of Environmental Sciences: Natural and Social Science Interface, Swiss Federal Institute of Technology, Zurich (ETH Zuerich), Universitaetsstrasse 22, ETH Zentrum CHN J76.3, CH-8092 Zurich (Switzerland)

    2006-06-15

    Much previous research on recycling behavior has drawn heavily on models of personal and perceived social norms, as well as of personal attitudes, to explain recycling behavior. Although such models have received empirical support, the issue concerning discrepancies between norms, personal attitudes and an individual's behavior is yet to be resolved. Using battery recycling in Switzerland as a case in point, the present questionnaire-based research examines via regression analyses the relationship between self-reported recycling behavior and socio-demographic variables, attitudes towards ecologically positive waste disposal, trust in waste disposal authorities, specific knowledge concerning recycling, justifications for not participating in the recycling scheme, self-organization of recycling behavior, and level of battery consumption. It was found that recycling knowledge, self-organization of recycling, and disagreement with justifications for non-recycling were positively related to recycling behavior, while attitudes towards ecological waste disposal and trust in waste disposal authorities were not directly related to respondents' self-reported battery recycling behavior. On the basis of these results, with reference to Sykes and Matza's Neutralization theory [Sykes GM, Matza D. Techniques of neutralization: a theory of delinquency. Am Sociol Rev 1957:22(6):664-70] a contextualized model of recycling behavior is proposed. This model is able to account for inconsistencies between personal attitudes and perceived social norms, and has practical implications for the design of public intervention strategies for enhancing participation in the recycling. (author)

  2. AS MULHERES E AS NAÇÕES UNIDAS: AS LINHAGENS DO PLANO MUNDIAL DE POPULAÇÃO

    Directory of Open Access Journals (Sweden)

    Carmen Barroso

    1989-06-01

    Full Text Available Nos anos 70 a ONU passou a dar uma definição mais ampla aos direitos da mulher e a adotar uma política de “integração da mulher ao desenvolvimento”. Um marco divisório da emergência desta questão nos fóruns intergovernamentais foi a Conferência Mundial de População promovida pela ONU em 1974 quando, no bojo de uma redefinição dos problemas demográficos no contexto econômico e cultural e de uma reafirmação do caráter político da questão populacional, passa-se a enfatizar a necessidade de promover a participação da mulher na vida social, econômica, cultural e política. O artigo analisa as duas linhagens de pensamento - a do controle da natalidade e a desenvolvimentista - que estão na raiz da preocupação com a questão da mulher que, de fato, vinha crescendo no âmbito da ONU desde o final dos anos 60.

  3. Estereotipos hacia los ancianos

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    Marta Gil Barreiro

    1997-02-01

    Full Text Available Se realizó un estudio descriptivo en 4 grupos etáreos diferentes: 20; 40; 60 y 70 años, del área de salud que abarca el Policlínico Docente "Lawton", con vistas a determinar cómo se estructuran los estereotipos hacia los ancianos. El instrumento de evaluación utilizado se confeccionó para la ocasión: la escala de adjetivos. El estereotipo más positivo hacia los ancianos lo evidenciaron los individuos de 40 años, a los que le siguieron, en orden decreciente, los de 70; 20 y 60 años.A descriptive study was a carried out in four different age groups: 20, 40, 60, and 70 years old, in the health area belonging to the "Lawton" Teaching Policlinic, in order to determine how the stereotypes towards the older people are formulated. The adjective scale was the assessing instrument built for the ocassion. The most positive stereotype towards the elder was demonstrated by individuals 40 years of age, followed in decreasing order, by the 70, 20, and 60 years old groups.

  4. Nanomolar detection of methylparaben by a cost-effective hemoglobin-based biosensor.

    Science.gov (United States)

    Hajian, A; Ghodsi, J; Afraz, A; Yurchenko, O; Urban, G

    2016-12-01

    This work describes the development of a new biosensor for methylparaben determination using electrocatalytic properties of hemoglobin in the presence of hydrogen peroxide. The voltammetric oxidation of methylparaben by the proposed biosensor in phosphate buffer (pH=7.0), a physiological pH, was studied and it was confirmed that methylparaben undergoes a one electron-one proton reaction in a diffusion-controlled process. The biosensor was fabricated by carbon paste electrode modified with hemoglobin and multiwalled carbon nanotube. Based on the excellent electrochemical properties of the modified electrode, a sensitive voltammetric method was used for determination of methylparaben within a linear range from 0.1 to 13μmolL(-1) and detection limit of 25nmolL(-1). The developed biosensor possessed accurate and rapid response to methylparaben and showed good sensitivity, stability, and repeatability. Finally, the applicability of the proposed biosensor was verified by methylparaben evaluation in various real samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Nanomolar detection of methylparaben by a cost-effective hemoglobin-based biosensor

    International Nuclear Information System (INIS)

    Hajian, A.; Ghodsi, J.; Afraz, A.; Yurchenko, O.; Urban, G.

    2016-01-01

    This work describes the development of a new biosensor for methylparaben determination using electrocatalytic properties of hemoglobin in the presence of hydrogen peroxide. The voltammetric oxidation of methylparaben by the proposed biosensor in phosphate buffer (pH = 7.0), a physiological pH, was studied and it was confirmed that methylparaben undergoes a one electron-one proton reaction in a diffusion-controlled process. The biosensor was fabricated by carbon paste electrode modified with hemoglobin and multiwalled carbon nanotube. Based on the excellent electrochemical properties of the modified electrode, a sensitive voltammetric method was used for determination of methylparaben within a linear range from 0.1 to 13 μmol L −1 and detection limit of 25 nmol L −1 . The developed biosensor possessed accurate and rapid response to methylparaben and showed good sensitivity, stability, and repeatability. Finally, the applicability of the proposed biosensor was verified by methylparaben evaluation in various real samples. - Highlights: • A new methylparaben biosensor was constructed by modification of carbon paste electrode with hemoglobin and MWCNTs. • The electrochemical properties of the modified electrode and electrochemical behavior of the methylparaben on the electrode surface were studied. • The response of modified GCE was analyzed by voltammetry technique (CV and DPV). • The electrode was used to the determination of methylparaben in real samples • The performance of the fabricated biosensor was satisfactorily compared to the previously reported electrochemical sensors for methylparaben determination.

  6. The thickness of the A1 pulleys reflects the disability of hand mobility in scleroderma. A pilot study using high-frequency ultrasound

    International Nuclear Information System (INIS)

    Tagliafico, Alberto; Panico, Nicoletta; Serafini, Giovanni; Ghio, Massimo; Martinoli, Carlo

    2011-01-01

    Background: Hand involvement in scleroderma is a serious concern. Clinical tests to asses hand dysfunction are based on the experience of the clinician. Objective: To asses if utrasonographic (US) measurement of A1 pulley thickness may be used as an indicator of hand mobility in scleroderma. Materials and methods: Institutional review board approval and patient informed consent was obtained. Twenty-eight patients affected suffering from scleroderma and 40 healthy controls were prospectively evaluated by two blinded radiologists with US, with a transducer operating at 17 MHz. A1 pulley thickness was measured and correlated with the Hand Mobility in Scleroderma Test (HAMIS) and disease duration. Results: The thickness of the A1 pulley was greater in sclerodermic patients than in controls (p < 0.05). Intra and inter-observer agreement were better for ultrasound (0.94;0.88) than for HAMIS tests (0.71;0.70). A good correlation between pulley thickness, hand mobility and disease duration was found (r = 0.78, p < 0.018; r = 0.54, p < 0.05). Conclusion: A1 pulley thickness measured on ultrasound correlates with hand mobility and disease duration. Ultrasound is an useful tool to evaluate hand disability in scleroderma.

  7. Normal stress-only myocardial single photon emission computed tomography predicts good outcome in patients with coronary artery stenoses between 40 and 70.

    Science.gov (United States)

    Jiang, Zhixin; Liu, Yangqing; Xin, Chaofan; Zhou, Yanli; Wang, Cheng; Zhao, Zhongqiang; Li, Chunxiang; Li, Dianfu

    2016-09-01

    Normal stress myocardial single photon emission computed tomography (SPECT) usually indicates good physiologic function of all coronary lesions, and also indicates a good outcome. We hypothesize that it can still predict good outcome in patients with coronary stenoses between 40 and 70%. A group of patients who underwent stress myocardial SPECT after coronary angiography were consecutively recruited in our center. Patients were eligible if they had one or more coronary stenoses between 40 and 70%. Patients with coronary stenoses greater than 50% diameter of left main or greater than 70% diameter of nonleft main epicardial vessels, and left ventricular ejection fraction less than 50% were excluded. The outcome was defined as major adverse events, including cardiac death, nonfatal myocardial infarction, and revascularization. Patients' survival curves were constructed accorded to the method of Kaplan and Meier and compared using the log-rank test. A study cohort of 77 patients was enrolled. According to the summed stress score, 43 patients were assigned to the perfusion defect group and 34 patients were assigned to the perfusion normal group. The follow-up duration was 6.4±0.3 years. In the perfusion normal group, only one of 34 (2.9%) patients developed major adverse events. In the perfusion defect group, six of 43 (14%) developed major adverse events, P-value of 0.041. It is safe to defer a percutaneous coronary intervention in patients with coronary stenoses between 40 and 70% and normal stress myocardial SPECT.

  8. Optimization of the Production of 1-Phenylethanol Using Enzymes from Flowers of Tea (Camellia sinensis Plants

    Directory of Open Access Journals (Sweden)

    Fang Dong

    2017-01-01

    Full Text Available 1-Phenylethanol (1PE can be used as a fragrance in food flavoring and cosmetic industries and as an intermediate in the pharmaceutical industry. 1PE can be synthesized from acetophenone, and the cost of 1PE is higher than the cost of acetophenone. Therefore, it is important to establish an effective and low-cost approach for producing 1PE. Our previous studies found that tea (Camellia sinensis flowers, which are an abundant and waste resource, contained enzymes that could transform acetophenone to 1PE. In the present study, we extracted crude enzymes from tea flowers and optimized the production conditions of 1PE using response surface methodology. The optimized conditions were an extraction pH of 7.0, a reaction pH of 5.3, a reaction temperature of 55 °C, a reaction time of 100 min, a coenzyme NADPH concentration of 3.75 μmol/mL in the reaction assay, and a substrate acetophenone concentration of 1.25 μmol/mL in the reaction assay. The results provide essential information for future industrial 1PE production using plant-derived enzymes.

  9. Not changes in membrane fluidity but proteotoxic stress triggers heat shock protein expression in Chlamydomonas reinhardtii.

    Science.gov (United States)

    Rütgers, Mark; Muranaka, Ligia Segatto; Schulz-Raffelt, Miriam; Thoms, Sylvia; Schurig, Juliane; Willmund, Felix; Schroda, Michael

    2017-12-01

    A conserved reaction of all organisms exposed to heat stress is an increased expression of heat shock proteins (HSPs). Several studies have proposed that HSP expression in heat-stressed plant cells is triggered by an increased fluidity of the plasma membrane. Among the main lines of evidence in support of this model are as follows: (a) the degree of membrane lipid saturation was higher in cells grown at elevated temperatures and correlated with a lower amplitude of HSP expression upon a temperature upshift, (b) membrane fluidizers induce HSP expression at physiological temperatures, and (c) membrane rigidifier dimethylsulfoxide dampens heat-induced HSP expression. Here, we tested whether this holds also for Chlamydomonas reinhardtii. We show that heat-induced HSP expression in cells grown at elevated temperatures was reduced because they already contained elevated levels of cytosolic HSP70A/90A that apparently act as negative regulators of heat shock factor 1. We find that membrane rigidifier dimethylsulfoxide impaired translation under heat stress conditions and that membrane fluidizer benzyl alcohol not only induced HSP expression but also caused protein aggregation. These findings support the classical model for the cytosolic unfolded protein response, according to which HSP expression is induced by the accumulation of unfolded proteins. Hence, the membrane fluidity model should be reconsidered. © 2017 John Wiley & Sons Ltd.

  10. Cáncer de próstata. Factores de riesgo en la provincia de Holguín

    Directory of Open Access Journals (Sweden)

    Rene Salas-Cabrera

    2011-01-01

    Full Text Available Se abordó un estudio epidemiológico observacional analítico de casos y controles para identificar los posibles factores de riesgo asociados al cáncer prostático en pacientes pertenecientes al municipio de Holguín, atendidos en la consulta central provincial de cáncer depróstata del hospital General Universitario "Vladimir Ilich Lenin" en el período Enero del 2001 a diciembre de 2010. El universo de estudio estuvo constituido por 1560 individuos, de ellos 520 casos y 1040 controles. Se aplicó la técnicade regresión logística con respuesta dicotómica. La totalidad de los pacientes resultaron ser mayores de 70 años. Resultaron variables estadísticamente significativas la edad, el hábito de fumar, el consumo de bebidas alcohólicas, los antecedentes patológicos familiares de cáncer de próstata y la obesidad.

  11. Cataratas senil bilateral psicológico pre y posoperatorio Bilateral senile cataract: a pre- and postoperavitve psychological study

    Directory of Open Access Journals (Sweden)

    Armando Rodríguez Romero

    2003-12-01

    Full Text Available Se realizó un estudio psicológico comparativo en 50 pacientes con catarata senil bilateral antes y después de la operación, en el período comprendido de enero a diciembre de1999 según las variables de edad, escolaridad y estado civil. Predominó el grupo etáreo de 70 a 79 años, nivel escolar primario y estado civil casado. Los síntomas psicopatológicos y la distribución según trastornos psiquiátricos disminuyeron después de restablecida su visión una vez operados de cataratas, en los de ansiedad y tristeza de 42 a7 pacientes respectivamente.A psychological comparative study was conducted among 50 patients with senile bilareral cataract before and after the operation from January to December, 1999, according to the following variables: age, educational level and marital status. The age group 70-79, the elementary educational level and the married patients predominated. The psychopathological symptoms and the distribution according to psychiatric disorders decreased among those with anxiety and sadness from 42 to 7 patients, respectively, once they were operated on of cataract and their vision was reestablished.

  12. Fabrication of a white-light-emitting organic LED adopting the two-wavelength method by using new DPVBi derivatives and an analysis of its characteristics

    International Nuclear Information System (INIS)

    Oh, Hwan-Sool; Cho, Jae-Young; Yoon, Seok-Beom; Kang, Myung-Koo

    2004-01-01

    The white-light emission of the two-wavelength method was represented by the processes of compounding new DPVBi derivatives, methyl-DPVT and nitro-DPVT, from the blue-emitting material DPVBi, after which blue light was emitted from nitro-DPVT and orange light was emitted by doping methyl-DPVT as a host material with Rubrene as a guest material. The basic structure of the fabricated organic white-light-emitting organic light-emitting device (OLED) was glass/ITO/NPB(150 A)/nitro-DPVT(100 A)/methyl-DPVT:Rubrene [2.0 wt%]/BCP(70 A)/Alq 3 (150 A)/Al(600 A).We evaluated the characteristics by varying the thickness of the methyl-DPVT:Rubrene layer from 100 A to 90 A to 80 A to 60 A and obtained nearly-pure white light in the Commission Internationale de l'Eclairage (CIE) coordinates (0.3175, 0.3338) in the case where the methyl-DPVT:Rubrene layer was 60-A thick. It turned out that the device remained stable against voltage changes, the turn-on voltage was 3.5 V, the light-emitting turn-on voltage was 4 V, and the external quantum efficiency was more than 0.5 % for all injection currents.

  13. Analysis of the characteristics of a white organic LED using the newly synthesized blue material methyl-DPVT by varying the thickness of the DPVBi layer

    International Nuclear Information System (INIS)

    Oh, Hwan-Sool; Cho, Jae-Young; Yoon, Seok-Beom

    2004-01-01

    A two-wavelength type of white organic light-emitting diode (OLED) having a blue/orange emitting layer was fabricated by synthesizing Methyl-DPVT, a new derivative of the blue-emitting material DPVBi on the market. The white-emission of the two-wavelength type was successfully obtained by representing not only blue emission by using DPVBi but also orange emission by using methyl-DPVT as a host material and Rubrene as a guest material. The basic structure of the fabricated white OLED is glass/ITO/NPB(150 A)/DPVBi/methyl-DPVT :Rubrene [2.0 wt%](100 A)/BCP(70 A)/Alq 3 (150 A)/Al(600 A). To evaluate the characteristics of the devices, we varied the thickness of the DPVBi layer from 100 A to 80 A to 60 A. A nearly pure white-emission was obtained in CIE coordinates of (0.3327, 0.3397) when the DPVBi layer was 60-A thick at an applied voltage of 11 V. The device started to operate at 1 V and to emit light at 2.5 V. The external quantum efficiency was above 0.5 % both when almost all of the current was injected and the applied voltage was over 10 V. A superior maximum quantum effciency of 0.746 % was obtained at an applied voltage of 18.5 V.

  14. Development and validation of a new tool measuring nurses self-reported professional competence--the nurse professional competence (NPC) Scale.

    Science.gov (United States)

    Nilsson, Jan; Johansson, Eva; Egmar, Ann-Charlotte; Florin, Jan; Leksell, Janeth; Lepp, Margret; Lindholm, Christina; Nordström, Gun; Theander, Kersti; Wilde-Larsson, Bodil; Carlsson, Marianne; Gardulf, Ann

    2014-04-01

    To develop and validate a new tool intended for measuring self-reported professional competence among both nurse students prior to graduation and among practicing nurses. The new tool is based on formal competence requirements from the Swedish Board of Health and Welfare, which in turn are based on WHO guidelines. A methodological study including construction of a new scale and evaluation of its psychometric properties. 1086 newly graduated nurse students from 11 universities/university colleges. The analyses resulted in a scale named the NPC (Nurse Professional Competence) Scale, consisting of 88 items and covering eight factors: "Nursing care", "Value-based nursing care", "Medical/technical care", "Teaching/learning and support", "Documentation and information technology", "Legislation in nursing and safety planning", "Leadership in and development of nursing care" and "Education and supervision of staff/students". All factors achieved Cronbach's alpha values greater than 0.70. A second-order exploratory analysis resulted in two main themes: "Patient-related nursing" and "Nursing care organisation and development". In addition, evidence of known-group validity for the NPC Scale was obtained. The NPC Scale, which is based on national and international professional competence requirements for nurses, was comprehensively tested and showed satisfactory psychometrical properties. It can e.g. be used to evaluate the outcomes of nursing education programmes, to assess nurses' professional competences in relation to the needs in healthcare organisations, and to tailor introduction programmes for newly employed nurses. © 2013.

  15. Detail design of the beam source for the SPIDER experiment

    International Nuclear Information System (INIS)

    Marcuzzi, D.; Agostinetti, P.; Dalla Palma, M.; Degli Agostini, F.; Pavei, M.; Rizzolo, A.; Tollin, M.; Trevisan, L.

    2010-01-01

    The ITER Neutral Beam Test Facility (PRIMA-Padova Research on Injector Megavolt Accelerated) is planned to be built at Consorzio RFX (Padova, Italy). PRIMA includes two experimental devices: a full size plasma source with low voltage extraction called SPIDER (Source for Production of Ion of Deuterium Extracted from RF plasma) and a full size neutral beam injector at full beam power called MITICA (Megavolt ITER Injector Concept Advancement). SPIDER is the first experimental device to be built and operated, aiming at testing the extraction of a negative ion beam (made of H - and in a later stage D - ions) from an ITER size ion source. The main requirements of this experiment are a H - /D - current of approximately 70 A/50 A and an energy of 100 keV. This paper presents an overview of the SPIDER beam source design, with a particular focus on the main design choices, aiming at reaching the best compromise between physics, optics, thermo-mechanical, cooling, assembly and electrical requirements.

  16. Speech on Antarctica of the Minister of Foreign Affairs Mr. Raúl Juliet Gómez in the Chilean Senate, in extraordinary session of January 21th, 1947

    Directory of Open Access Journals (Sweden)

    Raúl Juliet Gómez

    2017-05-01

    Full Text Available Al conmemorarse 70 años desde el establecimiento de la primera base chilena antártica, entonces llamada Base Soberanía, hoy Base Prat, ha parecido relevante publicar el texto de la exposición hecha ante el Senado el 21 de enero de 1947 por el entonces Canciller del gobierno del Presidente Gabriel González Videla. En ella se hace una revisión general tanto de los fundamentos de los derechos antárticos chilenos como de las actividades realizadas al respecto en aquellos años, entre otras, la expedición que establecería la citada base. En 1948, el Presidente González Videla sería el primer Jefe de Estado del mundo en llegar hasta la Antártica, visitaría la Base Soberanía e inauguraría una segunda estación chilena, la Base O’Higgins.

  17. Distribuição Espacial e Cobertura de Vegetação das Tipologias de Áreas Verdes de Curitiba, PR

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    Mayssa Mascarenhas Grise

    Full Text Available RESUMO A vegetação nas cidades desempenha funções ecológicas, estéticas e sociais que melhoram a qualidade de vida urbana. Para que essas funções sejam eficientes é necessário a realização de estudos quantitativos e qualitativos das áreas verdes (AVs na cidade. O objetivo do estudo foi identificar a cobertura de vegetação presente nas diferentes tipologias de AVs nas unidades administrativas de Curitiba, PR, bem como analisar sua configuração espacial ao longo da paisagem urbana. A cobertura de vegetação foi identificada por meio da classificação por árvore de decisão de imagens de satélite de alta resolução espacial – GeoEye-1. Conclui-se que Curitiba possui menos de 5% de sua área constituída por AVs, as quais, em sua maioria, apresentaram cobertura de vegetação acima de 70%. A distribuição espacial delas é desigual em quantidade e irregular quanto à sua disposição. A unidade administrativa da região Sul carece de AVs de todas as tipologias estabelecidas pela municipalidade.

  18. Sorption of strontium by magnetically modified yeast cells

    International Nuclear Information System (INIS)

    Hu Yantao; Ji Yanqin; Tian Qing; Shao Xianzhang; Shi Jianhe; Ivo Safarik; Zhang Shengdong; Li Jinying

    2008-01-01

    Magnetically modified fodder's yeast (Kluyveromyces fragilis) cells using water based magnetic fluid, were characterized by scanning electron microscopy (SEM) and Vibrating Sample Magnetometer (VSM). The sorption-desorption properties of Sr 2+ by these yeast cells from nitrate salt of Sr 2+ were studied. The results demonstrated that the Sr 2+ sorption volume by these cells enhanced with increasing pH and reached a plateau between pH 4.0 and 7.0. A minor effect by temperature was observed. The sorption volumes are 19.5 mg/g and 53.5 mg/g from 10 ppm and 40 ppm Sr 2+ solution respectively within 20 min. The sorption of Sr 2+ in these cells can be desorbed under 0.1 mol/L HNO 3 solution. The maximum Sr 2+ sorption volume is 96.7 mg/g at 20℃. The sorption characteristic fits Langmuir model well with 140.8 mg/g calculated maximum sorption volume by these yeast cells. (authors)

  19. Electrochemical characterization of LiCoO2 as rechargeable electrode in aqueous LiNO3 electrolyte

    KAUST Repository

    Ruffo, Riccardo

    2011-06-01

    The development of lithium ion aqueous batteries is getting renewed interest due to their safety and low cost. We have demonstrated that the layer-structure LiCoO2 phase, the most commonly used electrode material in organic systems, can be successful delithiated and lithiated again in a water-based electrolyte at currents up to 2.70 A/g. The capacity is about 100 mAh/g at 0.135 A/g and can be tuned by cycling the electrode in different potential ranges. In fact, increasing the high cut-off voltage leads to higher specific capacity (up to 135 mAh/g) but the Coulomb efficiency is reduced (from 99.9% to 98.5%). The very good electrode kinetic is probably due to the high conductivity of the electrolyte solution (0.17 Scm- 1 at 25 °C) but this behavior is affected by the electrode load. © 2010 Elsevier B.V. All rights reserved.

  20. La victimización por violencia urbana: niveles y factores asociados en ciudades de América Latina y España

    Directory of Open Access Journals (Sweden)

    Cruz José Miguel

    1999-01-01

    Full Text Available En este artículo se comparan los niveles de victimización por diversas causas y se identifican los factores asociados con ella en ocho ciudades de América Latina y España. Con este propósito se utilizaron los datos del estudio multicéntrico ACTIVA, que se realizó en 1996 bajo la coordinación de la Organización Panamericana de la Salud. La muestra estudiada estuvo constituida por 10821 personas, repartidas entre las ciudades de Salvador de Bahía y Rio de Janeiro, Brasil; Cali, Colombia; Caracas, Venezuela; Madrid, España; San José, Costa Rica; San Salvador, El Salvador, y Santiago, Chile, que representan a la población de cada ciudad entre los 18 y 70 años de edad. Los resultados revelan que los niveles de victimización por diversos tipos de violencia son diferentes en cada ciudad y que las variables asociadas con la victimización con más frecuencia en las ciudades, aunque no en todas, son el sexo, la edad y el consumo de alcohol.

  1. Improvement of water treatment pilot plant with Moringa oleifera extract as flocculant agent.

    Science.gov (United States)

    Beltrán-Heredia, J; Sánchez-Martín, J

    2009-05-01

    Moringa oleifera extract is a high-capacity flocculant agent for turbidity removal in surface water treatment. A complete study of a pilot-plant installation has been carried out. Because of flocculent sedimentability of treated water, a residual turbidity occured in the pilot plant (around 30 NTU), which could not be reduced just by a coagulation-flocculation-sedimentation process. Because of this limitation, the pilot plant (excluded filtration) achieved a turbidity removal up to 70%. A slow sand filter was put in as a complement to installation. A clogging process was characterized, according to Carman-Kozeny's hydraulic hypothesis. Kozeny's k parameter was found to be 4.18. Through fouling stages, this k parameter was found to be up to 6.36. The obtained data are relevant for the design of a real filter in a continuous-feeding pilot plant. Slow sand filtration is highly recommended owing to its low cost, easy-handling and low maintenance, so it is a very good complement to Moringa water treatment in developing countries.

  2. Growth of strained InGaAs/GaAs quantum wells and index guided injection lasers over nonplanar substrates by molecular beam epitaxy

    International Nuclear Information System (INIS)

    Arent, D.J.; Galeuchet, Y.D.; Nilsson, S.; Meier, H.P.

    1990-01-01

    Strained InGaAs/GaAs quantum wells were grown on nonplanar substrates by molecular beam epitaxy and studied by scanning electron microscopy and low temperature spatially and spectrally resolved cathodoluminescence spectroscopy. For (100) ridges and grooves formed with (311)A sidewalls, almost complete removal of In from the strained quantum wells on the (311)A facet is observed. Corresponding increases of In content in the quantum wells grown on the (100) facets indicate that most if not all of the In is displaced from the (311)A facet via interplanar adatom migration. Ga adatom migration is also observed under our growth conditions such that quantum wells grown nominally near the critical layer thickness on structures less than ≅2.5 μm wide are no longer pseudomorphically strained, as detected by luminescence linewidth analysis. We present the first results of strained InGaAs/GaAs index guided injection lasers grown by single-step molecular beam epitaxy over nonplanar substrates and show that differences greater than 50 meV in the effective band gap of a 70 A quantum well can be achieved between the gain region and the nonabsorbing waveguide without relaxing the strain. Room temperature threshold currents as low as 6 mA for 4 μmx750 μm uncoated devices lasing continuously at a wavelength of 1.01 μm have been achieved

  3. Stable, highly-responsive and broadband photodetection based on large-area multilayered WS2 films grown by pulsed-laser deposition

    Science.gov (United States)

    Yao, J. D.; Zheng, Z. Q.; Shao, J. M.; Yang, G. W.

    2015-09-01

    The progress in the field of graphene has aroused a renaissance of keen research interest in layered transition metal dichalcogenides (TMDs). Tungsten disulfide (WS2), a typical TMD with favorable semiconducting band gap and strong light-matter interaction, exhibits great potential for highly-responsive photodetection. However, WS2-based photodetection is currently unsatisfactory due to the low optical absorption (2%-10%) and poor carrier mobility (0.01-0.91 cm2 V-1 s-1) of the thin WS2 layers grown by chemical vapor deposition (CVD). Here, we introduce pulsed-laser deposition (PLD) to prepare multilayered WS2 films. Large-area WS2 films of the magnitude of cm2 are achieved. Comparative measurements of a WS2-based photoresistor demonstrate its stable broadband photoresponse from 370 to 1064 nm, the broadest range demonstrated in WS2 photodetectors. Benefiting from the large optical absorbance (40%-85%) and high carrier mobility (31 cm2 V-1 s-1), the responsivity of the device approaches a high value of 0.51 A W-1 in an ambient environment. Such a performance far surpasses the CVD-grown WS2-based photodetectors (μA W-1). In a vacuum environment, the responsivity is further enhanced to 0.70 A W-1 along with an external quantum efficiency of 137% and a photodetectivity of 2.7 × 109 cm Hz1/2 W-1. These findings stress that the PLD-grown WS2 film may constitute a new paradigm for the next-generation stable, broadband and highly-responsive photodetectors.The progress in the field of graphene has aroused a renaissance of keen research interest in layered transition metal dichalcogenides (TMDs). Tungsten disulfide (WS2), a typical TMD with favorable semiconducting band gap and strong light-matter interaction, exhibits great potential for highly-responsive photodetection. However, WS2-based photodetection is currently unsatisfactory due to the low optical absorption (2%-10%) and poor carrier mobility (0.01-0.91 cm2 V-1 s-1) of the thin WS2 layers grown by chemical vapor

  4. RUMINAL DEGRADATION KINETIC PARAMETERS OF COFFEE HULLS (Coffea arabica, L. TREATED WITH SODIUM HYDROXIDE (NAOH PARÂMETROS CINÉTICOS DA DEGRADAÇÃO RUMINAL DA CASCA DE CAFÉ (Coffea arabica, L. TRATADA COM HIDRÓXIDO DE SÓDIO (NAOH

    Directory of Open Access Journals (Sweden)

    Luciano Fernandes de Sousa

    2008-04-01

    Full Text Available The objective of this work was to evaluate dry matter ruminal degradation kinetics of coffee hulls treated with increasing sodium hydroxide quantities. Two rumen fistulated cows were used to incubate samples in nylon bags for 12. 24, 36. 48 and 72 hours. Four ruminal incubation periods were used, in a complete randomized block design. Coffee hulls were treated with 0%, 3%, 6% and 9% of sodium hydroxide (dry matter basis, corresponding to treatments T1 to t4 respectively. Experimental results were compared using Tukey test, at 5% probability level, as follows for treatments 1 to 4 respectively: soluble fraction (9.35d; 17.65c; 31.93b; 32.28a, de (34.40d; 40.50c; 43.28b; 50.35a, potential degradability (44.33d; 50.33c; 52.35b; 57.70a and lag time in hours (4.03a; 3.93a; 4.33a; 2.55a. The results indicate that increasing the levels of NaOH in the coffee hulls treatments increased significantly their ruminal solubility, as well as their effective and potential degradabilities. However that increase had no effect upon coffee hulls lag time in the rumen.KEY WORDS: by-product feedstuffs, rumen degradability, ruminant.

    O objetivo deste trabalho foi o de determinar a cinética de degradação ruminal da matéria seca da casca de café, tratada com diferentes quantidades de hidróxido de sódio. Utilizaram-se duas vacas fistuladas no rúmen, incubando-se as amostras em sacolas de náilon por 12, 24, 36, 48 e 72 horas, por quatro rodadas seqüenciais, sendo que cada uma destas representou um bloco, dentro de um delineamento de blocos inteiramente casualizados. Tratou-se a casca de café com 0%, 3%, 6% e 9 % de hidróxido de sódio (base seca constituindo assim os tratamentos t1

  5. Resultados de la técnica stop and chop en la facoemulsificación Results of stop and chop technique in phacoemulsification

    Directory of Open Access Journals (Sweden)

    Juan Raúl Hernández Silva

    2010-06-01

    Full Text Available OBJETIVOS: Describir los resultados morfofuncionales alcanzados con la técnica stop and chop en la cirugía de catarata por facoemulsificación (faco, en el Centro de Microcirugía Ocular del Instituto Cubano de Oftalmología "Ramón Pando Ferrer" entre Junio de 2006 y Marzo de 2009. MÉTODOS: Se realizó un estudio descriptivo, transversal en el cual el universo y la muestra del trabajo lo constituyeron todos los pacientes con diagnóstico de catarata presenil y senil, quienes cumplían con los criterios de selección y aceptaron someterse a la técnica quirúrgica señalada, lo cual correspondió a 201 ojos operados. Estos datos se analizaron a través de tablas de contingencia con frecuencias absolutas y relativas; además se emplearon medias con el uso del programa de procesamiento de datos SPSS versión 11.1, donde se aplicó la prueba t de student para su comparación. RESULTADOS: Se encontró que la catarata predominó en mayores de 70 años en el 33,4 % de los pacientes. La mejor agudeza visual con corrección obtenida se incrementó hasta siete líneas en la escala de Snellen en el 93,0 % de los casos; el cilindro refractivo apenas se modificó en 0,15 dioptrías; la pérdida de células endoteliales fue de 8,2 % y las complicaciones operatorias fueron de 1,5 %. CONCLUSIONES: La edad de los pacientes sometidos a cirugía de catarata por la técnica de stop and chop fue en su mayoría de más de 70 años. La MAVC posoperatoria ganó hasta siete líneas en la escala de Snellen; el astigmatismo que se indujo en la cirugía fue menor de media dioptría; la pérdida celular y las complicaciones posoperatorias no fueron significativas.OBJECTIVES: To describe the morphofunctional results of the stop and chop technique in cataract surgery in phacoemulsification at the Eye Microsurgery Center of "Ramón Pando Ferrer" Cuban Institute of Ophthalmology from June 2006 to March 2009. METHODS: A cross-sectional descriptive study was conducted. The

  6. Controllable synthesis of Ln3+ (Ln = Tb, Eu) doped zinc phosphate nano-/micro-structured materials: phase, morphology and luminescence properties

    Science.gov (United States)

    Yue, Dan; Lu, Wei; Li, Chunyang; Zhang, Xinlei; Liu, Chunxia; Wang, Zhenling

    2014-01-01

    Ln3+ (Ln = Tb, Eu) doped zinc phosphate tetrahydrate (ZPT:Ln3+) and ammonium zinc phosphate (AZP:Ln3+) nano-/micro-structured materials were synthesized in aqueous solution without the addition of any structure-directing agent. The phase structures, morphologies and luminescence properties of the as-synthesized samples were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), photoluminescence (PL) spectroscopy and lifetime. These investigations indicate that different phosphate sources MnH(3-n)PO4 (M = NH4+ or Na+, n = 1, 2, 3) can lead to the altering of morphology from nanosheet to microflower, but have no significant effect on the phase structure of the samples. The microlump, nanosheet, and microflower (constructed by the primary microlumps or nanosheets) of orthorhombic ZPT:Ln3+ could be selectively prepared by adjusting the pH value from 3.5 to 7.0. A mixture of orthorhombic ZPT:Ln3+ and monoclinic AZP:Ln3+ with a microflower morphology was obtained when the pH value was adjusted to 8.0. Monoclinic AZP:Ln3+ microplate, microcube and nanoparticle morphologies were obtained at pH values of 8.5, 9.0 and 11.0 respectively. The phase transformation and growth mechanism of the diverse morphologies were proposed, and ZPT:Ln3+ (Ln3+ = Eu or Tb) samples exhibit red or green emission under the excitation of UV light.Ln3+ (Ln = Tb, Eu) doped zinc phosphate tetrahydrate (ZPT:Ln3+) and ammonium zinc phosphate (AZP:Ln3+) nano-/micro-structured materials were synthesized in aqueous solution without the addition of any structure-directing agent. The phase structures, morphologies and luminescence properties of the as-synthesized samples were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), photoluminescence (PL) spectroscopy and lifetime. These investigations indicate that different phosphate sources MnH(3-n)PO4 (M = NH4+ or Na+, n = 1, 2, 3) can lead to the altering of morphology from nanosheet to microflower, but have no significant effect on the phase structure of the samples. The microlump, nanosheet, and microflower (constructed by the primary microlumps or nanosheets) of orthorhombic ZPT:Ln3+ could be selectively prepared by adjusting the pH value from 3.5 to 7.0. A mixture of orthorhombic ZPT:Ln3+ and monoclinic AZP:Ln3+ with a microflower morphology was obtained when the pH value was adjusted to 8.0. Monoclinic AZP:Ln3+ microplate, microcube and nanoparticle morphologies were obtained at pH values of 8.5, 9.0 and 11.0 respectively. The phase transformation and growth mechanism of the diverse morphologies were proposed, and ZPT:Ln3+ (Ln3+ = Eu or Tb) samples exhibit red or green emission under the excitation of UV light. Electronic supplementary information (ESI) available: Additional XRD patterns, EDX, SEM and TEM images, dependence of the average lifetimes on the different doping concentrations of Eu3+ and Tb3+. See DOI: 10.1039/c3nr03749e

  7. Factores asociados al ataque cerebrovascular isquémico entre los años 2013 a 2016: estudio de casos y controles

    Directory of Open Access Journals (Sweden)

    Juan-David Vega P.

    2017-11-01

    Full Text Available Resumen: Objetivo: Determinar los factores asociados al ataque cerebrovascular isquémico en el servicio de urgencias de la Clínica Especializada Los Andes, de la ciudad de Tunja, entre los años 2013 a 2016. Pacientes y métodos: Estudio de casos y controles; los casos correspondieron a 97 pacientes con ataque cerebrovascular isquémico (infarto cerebral isquémico y accidente isquémico transitorio y los controles a 291 pacientes sin ataque cerebrovascular isquémico que ingresaron a urgencias entre los años 2013 a 2016. Resultados: El sexo femenino correspondió al 56,7% (55 de los casos y al 54,6% de los controles (154 (p = 0,069. La media de edad en el grupo caso fue de 73,7 años [DE: 10,5 años] y en los controles de 64,5 años [DE: 11,3 años]. Los factores asociados al ataque cerebrovascular isquémico fueron: antecedente de ataque cerebrovascular isquémico [OR 7,7 IC 95% 3,2; 18 p= 0,000], tabaquismo [OR 4,4 IC 95% 1,1; 18 p= 0,022], dislipidemia [OR 3 IC 95% 1,2; 7,5 p= 0,017], edad igual o mayor a 70 años [OR 2,3 IC 95% 1,3; 4,1 p= 0,002] e hipertensión arterial [OR 1,8 IC 95% 1,06; 3,3 p= 0,029]. Conclusiones: Los factores asociados al ataque cerebrovascular isquémico fueron, en orden de importancia, antecedente de ataque cerebrovascular isquémico, tabaquismo, dislipidemia, edad igual o mayor a 70 años e hipertensión arterial. Abstract: Objective: To determine the factors associated with ischaemic cerebrovascular accidents (ICVA in the Emergency Department of the Andes Specialist Clinic of the city of Tunja, between the years 2013 and 2016. Patients and methods: A case-control study was conducted in which the cases consisted of 97 patients with ICVA (ischaemic cerebral infarction and transient ischaemic accident, and the controls were 291 patients with no ICVA, who were admitted to the Emergency Department between the years 2013 and 2016. Results: There were 56.7% (55

  8. Efectos a corto plazo de la contaminación atmosférica sobre la motalidad. Resultados del proyecto EMECAM en la ciudad de Barcelona, 1991-95

    Directory of Open Access Journals (Sweden)

    Saurina Carme

    1999-01-01

    Full Text Available FUNDAMENTOS: La mayoría de los estudios que muestran la existencia de una asociación a corto plazo entre contaminación atmosférica y morbimortalidad, analizan los efectos de los contaminantes `clásicos' cuya fuente es la combustión. Sin embargo, los cambios en las fuentes de emisión, fundamentalmente hacia el tráfico rodado, han modificado la contaminación atmosférica, haciendo más importante los componentes foto-químicos, como el ozono (O3 y el dióxido de nitrógeno (NO2. Barcelona es una ciudad situada en una zona templada y su contaminación atmosférica proviene principalmente de las emisiones de los vehículos. El principal objetivo de este artículo es el de analizar la relación entre los contaminantes foto-químicos, NO2 y O3, y la mortalidad por diferentes causas, en la ciudad de Barcelona desde 1991 hasta 1995, utilizando el protocolo de análisis elaborado dentro del proyecto EMECAM. MÉTODOS: Variaciones diarias del número de muertes por todas las causas, del número de muertes por todas las causas entre mayores de 70 años, del número de muertes por causas del aparato circulatorio y por causas respiratorias se relacionan con las variaciones diarias de los contaminantes foto-químicos, a través de modelos de Poisson autoregresivos, controlando confusores como la temperatura, la humedad relativa, la estructura temporal sistemática y la estructura autoregresiva. RESULTADOS: Excepto la relación entre O3 y mortalidad a causa de enfermedades respiratorias, las relaciones entre contaminantes foto-químicos y mortalidad por todas las causas consideradas resultaron estadísticamente significativas. Los riesgos relativos de morir ante incrementos de O3 fueron mayores que ante incrementos de NO2, casi el triple entre enfermedades del aparato circulatorio. Los riesgos relativos de morir por todas las causas son menores que por causas específicas y que para aquellos individuos mayores de 70 años. Los resultados del an

  9. Mortalidad atribuible al consumo de tabaco en México

    Directory of Open Access Journals (Sweden)

    Pablo Kuri-Morales

    2002-01-01

    Full Text Available Objetivo. Estudiar la asociación entre defunciones registradas en la delegación Coyoacán y consumo de tabaco y alcohol. Material y métodos. Estudio de mortalidad proporcional y determinación de fracción atribuible en una cohorte de sujetos de la ciudad de México, D.F., México. Se reunió información de todas las defunciones de 1998 captadas a través del Sistema Estadístico y Epidemiológico de las Defunciones (SEED en la delegación Coyoacán, clasificándolas por diagnóstico en enfermedades del sistema circulatorio (ESC, sistema respiratorio (EPOC, neoplasias (NEO. Se encuestó a familiares de los fallecidos sobre consumo de tabaco y alcohol. Resultados. Fumar los últimos 10 años de vida fue significativo para ESC en hombres de 70 años y más (RM: 2.06, IC 95%=1.18-3.58; y continuar fumando el último año de vida fue significativo para NEO y para EPOC en mujeres de 70 años y más (NEO= RM: 7.24, IC 95%=1.71-30.53; ESR= RM: 4.82, IC 95%=1.41-16.50. En el modelo de regresión para ESC, las personas con tabaquismo intenso tuvieron una posibilidad 0.83 veces mayor de fallecer por ESC, y el RA de esta variable para las ESC en la población general fue 45%. (RM=1.83; IC 95% = 1.1-2.8 pObjective. To study the mortality attributable to tobacco and alcohol consumption. Material and Methods. Deaths occurring in 1998, abstracted from the mortality statistics registry in the Coyoacan District of Mexico City, were classified by cause as: Cardiovascular Diseases, Respiratory Diseases, and Neoplasias. Relatives of the deceased were interviewed to answer a questionnaire on tobacco smoking and alcohol drinking. Results. Smoking during the last ten years of life was significantly associated with cardiovascular disease in men aged 70 years or older (OR 2.06, 95% CI 1.18-3.58. Persistent smoking in the last year of life was significantly associated with deaths from neoplasias and respiratory diseases in women aged 70 years or older (OR: 7.24, 95

  10. Estabilidad estructural del suelo bajo diferentes sistemas y tiempo de uso en laderas andinas de Nariño, Colombia Soil structural stability under different use systems and time in andean hillsides of Nariño, Colombia

    Directory of Open Access Journals (Sweden)

    Belisario Volverás Mambuscay

    2009-01-01

    Full Text Available Con el fin de evaluar el impacto de largos periodos de uso del terreno en propiedades estructurales del suelo, se realizó un muestreo a 0-20 cm de profundidad en los siguientes tratamientos: Suelo no intervenido 25% de pendiente (testigo, uso en pastura por 25 años 25% de pendiente y uso agrícola rotación trigo-maíz (rt-m de 25, 45 y 70 años de uso a 12% y 25% de pendiente, en un Inceptisol de la zona de reconversión del cultivo de trigo de Nariño (2.400 a 2.800 msnm, Colombia (longitud 75º 14' oeste, latitud 0.5º 10' norte, 2710 msnm, 80% HR, 12ºC. Los resultados mostraron diferencias significativas entre el tipo e intensidad de uso del suelo por largos periodos en distribución de tamaño de agregados secos al aire, estabilidad de agregados al agua y distribución de tamaño de poros. El incremento de la intensidad de uso disminuyó la estabilidad estructural y afectó la porosidad del suelo. El porcentaje de agregados estables al agua mayores a 2.0 mm fue significativamente mayor en suelo no intervenido (51.5%. El cambio a uso agrícola (rt-m durante 25, 45 y 70 años disminuyó los agregados estables mayores a 2.0 mm a 36.9%, 35.3% y 29.1% respectivamente. La porosidad total del uso en pastura disminuyó en 18% respecto al testigo y tendió a disminuir al aumentar la intensidad de uso del suelo rt-m.To evaluate the impact of different land use systems for long periods of time on soil structural properties, a sampling to 0-20 cm of depth was carried in the following treatments: Forest 25% slope (control, pasture crops for 25 years with 25% slope and use agricultural wheat-corn (rw-c of 25, 45 and 70 years of use, each one of these last, with 12% and 25% slope, in a Inceptisol (Dystric haplustepts of the area of reconversion of the wheat cropping area located at 2.400 to 2.800 masl in the Andean zone of the department of Nariño, Colombia (longitude 75º 14' west, latitude 0.5º 10' north, 2710 msnm, 80% RH, 12ºC. Results showed

  11. Unintentional injury and its prevention in infant: knowledge and self-reported practices of main caregivers.

    Science.gov (United States)

    Ramdzan, Siti Nurkamilla; Liew, Su May; Khoo, Ee Ming

    2014-05-29

    Unintentional injuries are the major cause of morbidity and mortality in infants. Prevention of unintentional injuries has been shown to be effective with education. Understanding the level of knowledge and practices of caregivers in infant safety would be useful to identify gaps for improvement. A cross-sectional study was conducted in an urban government health clinic in Malaysia among main caregivers of infants aged 11 to 15 months. Face-to-face interviews were conducted using a semi-structured self-designed questionnaire. Responses to the items were categorised by the percentage of correct answers: poor (70%). A total of 403 caregivers participated in the study. Of the 21 items in the questionnaire on knowledge, 19 had good-to-moderate responses and two had poor responses. The two items on knowledge with poor responses were on the use of infant walkers (26.8%) and allowing infants on motorcycles as pillion riders (27.3%). Self-reported practice of infant safety was poor. None of the participants followed all 19 safety practices measured. Eight (42.1%) items on self-reported practices had poor responses. The worst three of these were on the use of baby cots (16.4%), avoiding the use of infant walkers (23.8%) and putting infants to sleep in the supine position (25.6%). Better knowledge was associated with self-reported safety practices in infants (p safety was good but self-reported practice was poor. Further research in the future is required to identify interventions that target these potentially harmful practices.

  12. Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity.

    Science.gov (United States)

    Li, Jing-Ya; Cui, Yong-Mei; Chen, Ling-Ling; Gu, Min; Li, Jia; Nan, Fa-Jun; Ye, Qi-Zhuang

    2004-05-14

    Methionine aminopeptidase (MetAP) catalyzes the removal of methionine from newly synthesized polypeptides. MetAP carries out this cleavage with high precision, and Met is the only natural amino acid residue at the N terminus that is accepted, although type I and type II MetAPs use two different sets of residues to form the hydrophobic S1 site. Characteristics of the S1 binding pocket in type I MetAP were investigated by systematic mutation of each of the seven S1 residues in Escherichia coli MetAP type I (EcMetAP1) and human MetAP type I (HsMetAP1). We found that Tyr-65 and Trp-221 in EcMetAP1, as well as the corresponding residues Phe-197 and Trp-352 in HsMetAP1, were essential for the hydrolysis of a thiopeptolide substrate, Met-S-Gly-Phe. Mutation of Phe-191 to Ala in HsMetAP1 caused inactivity in contrast to the full activity of EcMetAP1(Y62A), which may suggest a subtle difference between the two type I enzymes. The more striking finding is that mutation of Cys-70 in EcMetAP1 or Cys-202 in HsMetAP1 opens up the S1 pocket. The thiopeptolides Leu-S-Gly-Phe and Phe-S-Gly-Phe, with previously unacceptable Leu or Phe as the N-terminal residue, became efficient substrates of EcMetAP1(C70A) and HsMetAP1(C202A). The relaxed specificity shown in these S1 site mutants for the N-terminal residues was confirmed by hydrolysis of peptide substrates and inhibition by reaction products. The structural features at the enzyme active site will be useful information for designing specific MetAP inhibitors for therapeutic applications.

  13. Nanoscale study on water damage for different warm mix asphalt binders

    Directory of Open Access Journals (Sweden)

    Kefei Liu

    2016-11-01

    Full Text Available In order to analyze the water damage to different warm mix asphalt binders from the micro scale, five kinds of asphalt binders, 70#A base asphalt, sasobit warm mix asphalt, energy champion 120 °C (EC120 warm mix asphalt, aspha-min warm mix asphalt, sulfur-extended asphalt modifier (SEAM warm mix asphalt, under different conditions (dry/wet, original/aging are prepared for laboratory tests. The atomic force microscope (AFM is used to observe the surface properties and measure the adhesion force between the asphalt and the mineral aggregate. The obtained results show that under the dry condition aspha-min warm mix asphalt and SEAM warm mix asphalt show stronger adhesive ability with the mineral aggregate compared with other asphalt binders, but also have relatively large dispersion and fluctuation in the tested results; under the wet condition, aspha-min warm mix asphalt and SEAM warm mix asphalt show stronger water damage resistance ability. The EC120 warm mix asphalt and aspha-min warm mix asphalt are less sensitive to moist, and their corresponding adhesion force is less susceptible to the change of external moisture conditions, leading to a better ability to resist water erosion. The aging process significantly lowers the moisture erosion resistance ability, which further impairs the water damage resistance ability. The base asphalt is more sensitive to moisture and more vulnerable to water damage, no matter whether it is under original or aging conditions. The aging aspha-min warm mix asphalt has the least loss of adhesion force, the smallest dispersion of the tested adhesion force, the strongest water damage resistance ability, no matter it is dry or wet. Keywords: Road engineering, Warm mix asphalt, Moisture damage, Atomic force microscope, Microcosmic

  14. Prevalence and Impact of Coexistent Bicuspid Aortic Valve in Hypertrophic Cardiomyopathy.

    Science.gov (United States)

    Padang, Ratnasari; Gersh, Bernard J; Ommen, Steve R; Geske, Jeffrey B

    2018-01-01

    The association between bicuspid aortic valve (BAV) and hypertrophic cardiomyopathy (HCM) has been reported but its true prevalence is unknown. This study investigated the prevalence and clinical impact of coexistent BAV in a large referral HCM population. Retrospective analysis of 3765 echocardiograms between 2004 and 2014 in 2640 consecutive patients with HCM was performed to assess for BAV. Patients with coexistent conditions were studied. Twenty-three patients (0.9%) were identified with coexisting BAV and HCM. Mean age was 52±16years, 18 males (78%), 16 with NYHA functional class I/II at initial evaluation (70%). A family history of HCM was present in five patients (22%); none had a family history of BAV or aortopathy. Maximal left ventricular wall thickness was 24±6mm; the majority had either reverse curve or sigmoid septal morphology. Moderate or greater aortic valve dysfunction was present in seven patients (30%), BAV-related aortopathy in 18 patients (78%) and dynamic left ventricular outflow tract (LVOT) obstruction in nine patients (39%). Three patients had combined LVOT obstruction and aortic stenosis. Median time from diagnosis of BAV or HCM to last follow-up was 11±12.5years. At last follow-up, 22% had undergone BAV-related surgeries, 30% had septal reduction therapy (SRT), and 17% had combined SRT and BAV-related surgeries. Overall survival was 95% at 10 years. This study reported a 0.9% prevalence of BAV among HCM population, similar to the general population. Aortopathy and LVOT obstruction were common, necessitating cardiac interventions in over one-third of cases. Long-term survival appeared favourable. Copyright © 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

  15. Single site mutations in the hetero-oligomeric Mrp antiporter from alkaliphilic Bacillus pseudofirmus OF4 that affect Na+/H+ antiport activity, sodium exclusion, individual Mrp protein levels, or Mrp complex formation.

    Science.gov (United States)

    Morino, Masato; Natsui, Shinsuke; Ono, Tomohiro; Swartz, Talia H; Krulwich, Terry A; Ito, Masahiro

    2010-10-01

    Mrp systems are widely distributed and structurally complex cation/proton antiporters. Antiport activity requires hetero-oligomeric complexes of all six or seven hydrophobic Mrp proteins (MrpA-MrpG). Here, a panel of site-directed mutants in conserved or proposed motif residues was made in the Mrp Na(+)(Li(+))/H(+) antiporter from an alkaliphilic Bacillus. The mutant operons were expressed in antiporter-deficient Escherichia coli KNabc and assessed for antiport properties, support of sodium resistance, membrane levels of each Mrp protein, and presence of monomeric and dimeric Mrp complexes. Antiport did not depend on a VFF motif or a conserved tyrosine pair, but a role for a conserved histidine in a potential quinone binding site of MrpA was supported. The importance of several acidic residues for antiport was confirmed, and the importance of additional residues was demonstrated (e.g. three lysine residues conserved across MrpA, MrpD, and membrane-bound respiratory Complex I subunits (NuoL/M/N)). The results extended indications that MrpE is required for normal membrane levels of other Mrp proteins and for complex formation. Moreover, mutations in several other Mrp proteins lead to greatly reduced membrane levels of MrpE. Thus, changes in either of the two Mrp modules, MrpA-MrpD and MrpE-MrpG, influence the other. Two mutants, MrpB-P37G and MrpC-Q70A, showed a normal phenotype but lacked the MrpA-MrpG monomeric complex while retaining the dimeric hetero-oligomeric complex. Finally, MrpG-P81A and MrpG-P81G mutants exhibited no antiport activity but supported sodium resistance and a low [Na(+)](in). Such mutants could be used to screen hypothesized but uncharacterized sodium efflux functions of Mrp apart from Na(+) (Li(+))/H(+) antiport.

  16. Ready, set, go! Motivation and lifestyle habits in parents of children referred for obesity management.

    Science.gov (United States)

    Maximova, K; Ambler, K A; Rudko, J N; Chui, N; Ball, G D C

    2015-10-01

    Parents play a fundamental role in helping children with obesity to make and maintain healthy lifestyle changes. This study aimed to characterize stages of engagement to change nutrition and physical activity habits among parents whose children with obesity were enrolled in obesity management and examine differences in parents' own nutrition and physical activity habits according to their stage of engagement. Medical records of 113 children (body mass index [BMI] ≥95th percentile) enrolled in an outpatient weight management clinic were reviewed for baseline (cross-sectional) data. Parents completed the Weight Loss Behavior-Stage of Change Scale to assess the degree of engagement in making healthy changes to their lifestyle behaviours. Latent class analysis was used to classify parents into distinct clusters by grouping individuals with similar ratings of stages of engagement regarding nutrition- and physical activity-related behaviours. Parents' engagement in healthy lifestyle behaviours varied (more engaged [n = 43]; less engaged [n = 70]). A greater proportion of parents in the more engaged group was in action and/or maintenance stages of changing their lifestyle habits. The more engaged group was less overweight than the less engaged group (BMI = 28.5 vs. 33.3 kg m(-2); P healthy changes to their lifestyle behaviours, and those categorized as more engaged already demonstrated positive lifestyle behaviours. Information regarding parents' degree of engagement in healthy behaviours can inform clinical recommendations, especially when parents represent the primary agents of change in families trying to manage paediatric obesity. © 2014 World Obesity.

  17. Feasibility and Safety of Transradial Arterial Approach for Simultaneous Right and Left Vertebral Artery Angiographic Studies and Stenting

    International Nuclear Information System (INIS)

    Yip, H.-K.; Youssef, Ali A.; Chang, W.-N.; Lu, C.-H.; Yang, C.-H.; Chen, S.-M.; Wu, C.-J.

    2007-01-01

    Objectives. This study investigated whether the transradial artery (TRA) approach using a 6-French (F) Kimny guiding catheter for right vertebral artery (VA) angiographic study and stenting is safe and effective for patients with significant VA stenosis. Background. The TRA approach is commonly performed worldwide for both diagnostic cardiac catheterization and catheter-based coronary intervention. However, to our knowledge, the safety and feasibility of left and right VA angiographic study and stenting, in the same procedure, using the TRA approach for patients with brain ischemia have not been reported. Methods. The study included 24 consecutive patients (22 male, 2 female; age, 63-78 years). Indications for VA angiographic study and stenting were (1) prior stroke or symptoms related to vertebrobasilar ischemia and (2) an asymptomatic but vertebral angiographic finding of severe stenosis (>70%). A combination of the ipsilateral and retrograde-engagement technique, which involved a looping 6-F Kimny guiding catheter, was utilized for VA angiographic study. For VA stenting, an ipsilateral TRA approach with either a Kimny guiding catheter or a left internal mammary artery guiding catheter was utilized in 22 patients and retrograde-engagement technique in 2 patients. Results. A technically successful procedure was achieved in all patients, including left VA stenting in 15 patients and right VA stenting in 9 patients. The mean time for stenting (from engagement to stent deployment) was 12.7 min. There were no vascular complications or mortality. However, one patient suffered from a transient ischemic attack that resolved within 3 h. Conclusion. We conclude that TRA access for both VA angiographic study and VA stenting is safe and effective, and provides a simple and useful clinical tool for patients unsuited for femoral arterial access

  18. THE STRUCTURE OF PRE-TRANSITIONAL PROTOPLANETARY DISKS. II. AZIMUTHAL ASYMMETRIES, DIFFERENT RADIAL DISTRIBUTIONS OF LARGE AND SMALL DUST GRAINS IN PDS 70 {sup ,}

    Energy Technology Data Exchange (ETDEWEB)

    Hashimoto, J.; Wisniewski, J. [Department of Physics and Astronomy, The University of Oklahoma, 440 West Brooks Street, Norman, OK 73019 (United States); Tsukagoshi, T. [College of Science, Ibaraki University, Bunkyo 2-1-1, Mito 310-8512 (Japan); Brown, J. M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS 78, Cambridge, MA 02138 (United States); Dong, R. [Astronomy Department, University of California, Berkeley, CA 94720 (United States); Muto, T. [Division of Liberal Arts, Kogakuin University, 1-24-2, Nishi-Shinjuku, Shinjuku-ku, Tokyo 163-8677 (Japan); Zhu, Z. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Ohashi, N.; Kudo, T.; Egner, S.; Guyon, O. [Subaru Telescope, 650 North A' ohoku Place, Hilo, HI 96720 (United States); Kusakabe, N.; Akiyama, E. [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Abe, L. [Laboratoire Hippolyte Fizeau, UMR6525, Universite de Nice Sophia-Antipolis, 28, avenue Valrose, F-06108 Nice Cedex 02 (France); Brandner, W.; Carson, J.; Feldt, M. [Max Planck Institute for Astronomy, Königstuhl 17, D-69117 Heidelberg (Germany); Brandt, T. [Astrophysics Department, Institute for Advanced Study, Princeton, NJ (United States); Currie, T. [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, ON (Canada); Grady, C. A., E-mail: jun.hashimoto@ou.edu [Eureka Scientific, 2452 Delmer, Suite 100, Oakland, CA 96002 (United States); and others

    2015-01-20

    The formation scenario of a gapped disk, i.e., transitional disk, and its asymmetry is still under debate. Proposed scenarios such as disk-planet interaction, photoevaporation, grain growth, anticyclonic vortex, eccentricity, and their combinations would result in different radial distributions of the gas and the small (sub-μm size) and large (millimeter size) dust grains as well as asymmetric structures in a disk. Optical/near-infrared (NIR) imaging observations and (sub-)millimeter interferometry can trace small and large dust grains, respectively; therefore multi-wavelength observations could help elucidate the origin of complicated structures of a disk. Here we report Submillimeter Array observations of the dust continuum at 1.3 mm and {sup 12}CO J = 2 → 1 line emission of the pre-transitional protoplanetary disk around the solar-mass star PDS 70. PDS 70, a weak-lined T Tauri star, exhibits a gap in the scattered light from its disk with a radius of ∼65 AU at NIR wavelengths. However, we found a larger gap in the disk with a radius of ∼80 AU at 1.3 mm. Emission from all three disk components (the gas and the small and large dust grains) in images exhibits a deficit in brightness in the central region of the disk, in particular, the dust disk in small and large dust grains has asymmetric brightness. The contrast ratio of the flux density in the dust continuum between the peak position to the opposite side of the disk reaches 1.4. We suggest the asymmetries and different gap radii of the disk around PDS 70 are potentially formed by several (unseen) accreting planets inducing dust filtration.

  19. Magnetic resonance imaging in follow-up assessment of sciatica.

    Science.gov (United States)

    el Barzouhi, Abdelilah; Vleggeert-Lankamp, Carmen L A M; Lycklama à Nijeholt, Geert J; Van der Kallen, Bas F; van den Hout, Wilbert B; Jacobs, Wilco C H; Koes, Bart W; Peul, Wilco C

    2013-03-14

    Magnetic resonance imaging (MRI) is frequently performed during follow-up in patients with known lumbar-disk herniation and persistent symptoms of sciatica. The association between findings on MRI and clinical outcome is controversial. We studied 283 patients in a randomized trial comparing surgery and prolonged conservative care for sciatica and lumbar-disk herniation. Patients underwent MRI at baseline and after 1 year. We used a 4-point scale to assess disk herniation on MRI, ranging from 1 for "definitely present" to 4 for "definitely absent." A favorable clinical outcome was defined as complete or nearly complete disappearance of symptoms at 1 year. We compared proportions of patients with a favorable outcome among those with a definite absence of disk herniation and those with a definite, probable, or possible presence of disk herniation at 1 year. The area under the receiver-operating-characteristic (ROC) curve was used to assess the prognostic accuracy of the 4-point scores regarding a favorable or unfavorable outcome, with 1 indicating perfect discriminatory value and 0.5 or less indicating no discriminatory value. At 1 year, 84% of the patients reported having a favorable outcome. Disk herniation was visible in 35% with a favorable outcome and in 33% with an unfavorable outcome (P=0.70). A favorable outcome was reported in 85% of patients with disk herniation and 83% without disk herniation (P=0.70). MRI assessment of disk herniation did not distinguish between patients with a favorable outcome and those with an unfavorable outcome (area under ROC curve, 0.48). MRI performed at 1-year follow-up in patients who had been treated for sciatica and lumbar-disk herniation did not distinguish between those with a favorable outcome and those with an unfavorable outcome. (Funded by the Netherlands Organization for Health Research and Development and the Hoelen Foundation; Controlled Clinical Trials number, ISRCTN26872154.).

  20. Identification of the divergent calmodulin binding motif in yeast Ssb1/Hsp75 protein and in other HSP70 family members.

    Science.gov (United States)

    Heinen, R C; Diniz-Mendes, L; Silva, J T; Paschoalin, V M F

    2006-11-01

    Yeast soluble proteins were fractionated by calmodulin-agarose affinity chromatography and the Ca2+/calmodulin-binding proteins were analyzed by SDS-PAGE. One prominent protein of 66 kDa was excised from the gel, digested with trypsin and the masses of the resultant fragments were determined by MALDI/MS. Twenty-one of 38 monoisotopic peptide masses obtained after tryptic digestion were matched to the heat shock protein Ssb1/Hsp75, covering 37% of its sequence. Computational analysis of the primary structure of Ssb1/Hsp75 identified a unique potential amphipathic alpha-helix in its N-terminal ATPase domain with features of target regions for Ca2+/calmodulin binding. This region, which shares 89% similarity to the experimentally determined calmodulin-binding domain from mouse, Hsc70, is conserved in near half of the 113 members of the HSP70 family investigated, from yeast to plant and animals. Based on the sequence of this region, phylogenetic analysis grouped the HSP70s in three distinct branches. Two of them comprise the non-calmodulin binding Hsp70s BIP/GR78, a subfamily of eukaryotic HSP70 localized in the endoplasmic reticulum, and DnaK, a subfamily of prokaryotic HSP70. A third heterogeneous group is formed by eukaryotic cytosolic HSP70s containing the new calmodulin-binding motif and other cytosolic HSP70s whose sequences do not conform to those conserved motif, indicating that not all eukaryotic cytosolic Hsp70s are target for calmodulin regulation. Furthermore, the calmodulin-binding domain found in eukaryotic HSP70s is also the target for binding of Bag-1 - an enhancer of ADP/ATP exchange activity of Hsp70s. A model in which calmodulin displaces Bag-1 and modulates Ssb1/Hsp75 chaperone activity is discussed.

  1. Identification of the divergent calmodulin binding motif in yeast Ssb1/Hsp75 protein and in other HSP70 family members

    Directory of Open Access Journals (Sweden)

    R.C. Heinen

    2006-11-01

    Full Text Available Yeast soluble proteins were fractionated by calmodulin-agarose affinity chromatography and the Ca2+/calmodulin-binding proteins were analyzed by SDS-PAGE. One prominent protein of 66 kDa was excised from the gel, digested with trypsin and the masses of the resultant fragments were determined by MALDI/MS. Twenty-one of 38 monoisotopic peptide masses obtained after tryptic digestion were matched to the heat shock protein Ssb1/Hsp75, covering 37% of its sequence. Computational analysis of the primary structure of Ssb1/Hsp75 identified a unique potential amphipathic alpha-helix in its N-terminal ATPase domain with features of target regions for Ca2+/calmodulin binding. This region, which shares 89% similarity to the experimentally determined calmodulin-binding domain from mouse, Hsc70, is conserved in near half of the 113 members of the HSP70 family investigated, from yeast to plant and animals. Based on the sequence of this region, phylogenetic analysis grouped the HSP70s in three distinct branches. Two of them comprise the non-calmodulin binding Hsp70s BIP/GR78, a subfamily of eukaryotic HSP70 localized in the endoplasmic reticulum, and DnaK, a subfamily of prokaryotic HSP70. A third heterogeneous group is formed by eukaryotic cytosolic HSP70s containing the new calmodulin-binding motif and other cytosolic HSP70s whose sequences do not conform to those conserved motif, indicating that not all eukaryotic cytosolic Hsp70s are target for calmodulin regulation. Furthermore, the calmodulin-binding domain found in eukaryotic HSP70s is also the target for binding of Bag-1 - an enhancer of ADP/ATP exchange activity of Hsp70s. A model in which calmodulin displaces Bag-1 and modulates Ssb1/Hsp75 chaperone activity is discussed.

  2. Blood cadmium levels are associated with a decline in lung function in males

    International Nuclear Information System (INIS)

    Oh, Chang-Mo; Oh, In-Hwan; Lee, Jong-Keun; Park, Yoon Hyung; Choe, Bong-Keun; Yoon, Tai-Young; Choi, Joong-Myung

    2014-01-01

    Background: Cadmium exposure was found to cause a decline in lung function among the general population, but these findings were limited to smokers and gender differences were not explored. Objectives: To examine the relationship between cadmium and chronic obstructive pulmonary disease (COPD) according to gender and smoking status in Korea. Methods: Cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2011 were analyzed. COPD was defined by a pre-bronchodilator forced expiratory volume in 1 s divided by forced vital capacity of <0.70. A logistic regression model was used to elucidate the association between blood cadmium levels and COPD according to gender and smoking status. Results: Among 3861 eligible participants, 3622 were included in the analysis. The prevalence of COPD demonstrated an increasing trend in males (P for trend<0.001), but not in females (P for trend=0.67). After adjusting for covariates, a higher blood cadmium level, but within the normal range, was associated with COPD in males, including those who had never-smoked (P for trend <0.001 and P for trend=0.008). However, a higher blood cadmium level was not significantly associated with COPD in females, including those who had never smoked (P for trend=0.39 and P for trend=0.43). Conclusions: A higher blood cadmium level, within the normal range, was associated with COPD in males, including those who had never smoked. However, there was no significant association between blood cadmium levels and COPD in females. - Highlights: • Elevated blood cadmium level is associated with chronic obstructive pulmonary disease in male. • This association can be seen even in never smoked male. • However, this association is present only in male, but not in female

  3. Late-career unemployment and all-cause mortality, functional disability and depression among the older adults in Taiwan: A 12-year population-based cohort study.

    Science.gov (United States)

    Chu, Wei-Min; Liao, Wen-Chun; Li, Chi-Rong; Lee, Shu-Hsin; Tang, Yih-Jing; Ho, Hsin-En; Lee, Meng-Chih

    2016-01-01

    To evaluate whether late-career unemployment is associated with increased all-cause mortality, functional disability, and depression among older adults in Taiwan. In this long-term prospective cohort study, data were retrieved from the Taiwan Longitudinal Study on Aging. This study was conducted from 1996 to 2007. The complete data from 716 men and 327 women aged 50-64 years were retrieved. Participants were categorized as normally employed or unemployed depending on their employment status in 1996. The cumulative number of unemployment after age 50 was also calculated. Logistic regression analysis was used to examine the effect of the association between late-career unemployment and cumulative number of late-career unemployment on all-cause mortality, functional disability, and depression in 2007. The average age of the participants in 1996 was 56.3 years [interquartile range (IQR)=7.0]. A total of 871 participants were in the normally employed group, and 172 participants were in the unemployed group. After adjustment of gender, age, level of education, income, self-rated health and major comorbidities, late-career unemployment was associated with increased all-cause mortality [Odds ratio (OR)=2.79; 95% confidence interval (CI)=1.74-4.47] and functional disability [OR=2.33; 95% CI=1.54-3.55]. The cumulative number of late-career unemployment was also associated with increased all-cause mortality [OR=1.91; 95% CI=1.35-2.70] and functional disability [OR=2.35; 95% CI=1.55-3.55]. Late-career unemployment and cumulative number of late-career unemployment are associated with increased all-cause mortality and functional disability. Older adults should be encouraged to maintain normal employment during the later stage of their career before retirement. Employers should routinely examine the fitness for work of older employees to prevent future unemployment. Copyright © 2016. Published by Elsevier Ireland Ltd.

  4. A (Si VI) (1.92 micrometer) coronal line survey of galactic nuclei

    Science.gov (United States)

    Marconi, A.; Moorwood, A. F. M.; Salvati, M.; Oliva, E.

    1994-11-01

    We present the results of a (Si VI) lambda 1.962 emission line survey of active, starburst and IRAS luminous galaxies. The line was only detected in known Seyfert type 1 and 2 nuclei confirming previous suggestions that (Si VI) is related to Seyfert activity. By modeling the formation of (Si VI) and (Fe VIII) lambda 6087 we find further strong evidence that these lines arise in gas photoionized by the active nucleus although collisional ionization e.g. by shock fronts may be important in some galaxies exhibiting (Fe VII) much greater than (Si VI). Our failure to detect (Si VI) in the IRAS ultraluminous galaxies does not exclude the possible presence of obscured Active Galactic Nuclei (AGNs), particularly as some of the known Seyferts were also not detected. Molecular hydrogen lines (a by-product of our spectra) are common in all galaxy types including several IRAS ultraluminous galaxies whose H2 equivalent widths (Wlambda less that 20 A) are 'normal'and much lower than the extreme value (Wlambda approximately = 70 A) found in NGC 6240 and NGC 1275. 'Bare' Seyferts have Wlambda(H2) less than 1 A and a factor greater than or approximately 10 lower than starbursts, and we do not confirm previous claims of H2 line emission in the quasar 3C273. Although the ratio of H2 to (Si VI) emission varies over a wide range it does not appear to provide a useful indicator of activity type or to impose constraints on the He excitation mechanism.

  5. Progress in second-generation HTS wire development and manufacturing

    International Nuclear Information System (INIS)

    Selvamanickam, V.; Chen, Y.; Xiong, X.; Xie, Y.; Zhang, X.; Rar, A.; Martchevskii, M.; Schmidt, R.; Lenseth, K.; Herrin, J.

    2008-01-01

    2007 has marked yet another year of continued rapid progress in developing and manufacturing high-performance, long-length second-generation (2G) HTS wires at high speeds. Using ion beam assisted deposition (IBAD) MgO and associated buffer sputtering processes, SuperPower has now exceeded piece lengths of 1000 m of fully buffered tape reproducibly with excellent in-plane texture of 6-7 degrees and uniformity of about 2%. These kilometer lengths are produced at high speeds of about 350 m/h of 4 mm wide tape. In combination with metal organic chemical vapor deposition (MOCVD), 2G wires up to single piece lengths to 790 m with a minimum critical current value of 190 A/cm corresponding to a Critical current x Length performance of 150,100 Am have been achieved. Tape speeds up to 180 m/h have been reached MOCVD while maintaining critical currents above 200 A/cm in 100+ m lengths. Thick film MOCVD technology has been transitioned to Pilot manufacturing system where a minimum critical current of 320 A/cm has been demonstrated over a length of 155 m processed at a speed of 70 m/h in 4 mm width. Finally, nearly 10,000 m of 2G wire has been produced, exhaustively tested, and delivered to the Albany Cable project. The average minimum critical current of the wire delivered in 225 segments of 43-44 m is 70 A in 4 mm widths. A 30 m cable has been fabricated with this wire by Sumitomo Electric and has been installed in the power grid of National Grid in downtown Albany and is the world's first 2G device installed in the grid

  6. Progress in second-generation HTS wire development and manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Selvamanickam, V. [SuperPower, Inc., 450 Duane Avenue, Schenectady, NY 12304 (United States)], E-mail: vselva@superpower-inc.com; Chen, Y.; Xiong, X.; Xie, Y.; Zhang, X.; Rar, A.; Martchevskii, M.; Schmidt, R.; Lenseth, K.; Herrin, J. [SuperPower, Inc., 450 Duane Avenue, Schenectady, NY 12304 (United States)

    2008-09-15

    2007 has marked yet another year of continued rapid progress in developing and manufacturing high-performance, long-length second-generation (2G) HTS wires at high speeds. Using ion beam assisted deposition (IBAD) MgO and associated buffer sputtering processes, SuperPower has now exceeded piece lengths of 1000 m of fully buffered tape reproducibly with excellent in-plane texture of 6-7 degrees and uniformity of about 2%. These kilometer lengths are produced at high speeds of about 350 m/h of 4 mm wide tape. In combination with metal organic chemical vapor deposition (MOCVD), 2G wires up to single piece lengths to 790 m with a minimum critical current value of 190 A/cm corresponding to a Critical current x Length performance of 150,100 Am have been achieved. Tape speeds up to 180 m/h have been reached MOCVD while maintaining critical currents above 200 A/cm in 100+ m lengths. Thick film MOCVD technology has been transitioned to Pilot manufacturing system where a minimum critical current of 320 A/cm has been demonstrated over a length of 155 m processed at a speed of 70 m/h in 4 mm width. Finally, nearly 10,000 m of 2G wire has been produced, exhaustively tested, and delivered to the Albany Cable project. The average minimum critical current of the wire delivered in 225 segments of 43-44 m is 70 A in 4 mm widths. A 30 m cable has been fabricated with this wire by Sumitomo Electric and has been installed in the power grid of National Grid in downtown Albany and is the world's first 2G device installed in the grid.

  7. Shot-to-shot reproducibility of a self-magnetically insulated ion diode

    International Nuclear Information System (INIS)

    Pushkarev, A. I.; Isakova, Yu. I.; Khailov, I. P.

    2012-01-01

    In this paper we present the analysis of shot to shot reproducibility of the ion beam which is formed by a self-magnetically insulated ion diode with an explosive emission graphite cathode. The experiments were carried out with the TEMP-4M accelerator operating in double-pulse mode: the first pulse is of negative polarity (300–500 ns, 100–150 kV), and this is followed by a second pulse of positive polarity (150 ns, 250–300 kV). The ion current density was 10–70 A/cm 2 depending on the diode geometry. The beam was composed from carbon ions (80%–85%) and protons. It was found that shot to shot variation in the ion current density was about 35%–40%, whilst the diode voltage and current were comparatively stable with the variation limited to no more than 10%. It was shown that focusing of the ion beam can improve the stability of the ion current generation and reduces the variation to 18%–20%. In order to find out the reason for the shot-to-shot variation in ion current density we examined the statistical correlation between the current density of the accelerated beam and other measured characteristics of the diode, such as the accelerating voltage, total current, and first pulse duration. The correlation between the ion current density measured simultaneously at different positions within the cross-section of the beam was also investigated. It was shown that the shot-to-shot variation in ion current density is mainly attributed to the variation in the density of electrons diffusing from the drift region into the A-K gap.

  8. Development of positron emitting radionuclides for imaging with improved positron detectors

    International Nuclear Information System (INIS)

    Yano, Y.

    1976-10-01

    Recent advances in positron cameras and positron ring detectors for transverse section reconstruction have created renewed interest in positron emitting radionuclides. This paper reports on: generator-produced 82 Rb; cyclotron-produced 62 Zn; and reactor-produced 64 Cu. Investigation of the 82 Sr (25 d)-- 82 Rb (75 s) generator determined the elution characteristics for Bio-Rex 70, a weakly acidic carboxylic cation exchanger, using 2% NaCl as the eluent. The yield of 82 Rb and the breakthrough of 82 Sr were determined for newly prepared columns and for long term elution conditions. Spallation-produced 82 Sr was used to charge a compact 82 Rb generator to obtain multi-millicurie amounts of 82 Rb for myocardial imaging. Zinc accumulates in the islet cells of the pancreas and in the prostate. Zinc-62 was produced by protons on Cu foil and separated by column chromatography. Zinc-62 was administered as the amino acid chelates and as the ZnCl 2 to tumor and normal animals. Tissue distribution was determined for various times after intravenous injection. Pancreas-liver images of 62 Zn-histidine uptake were obtained in animals with the gamma camera and the liver uptake of /sup 99m/Tc sulfur colloid was computer subtracted to image the pancreas alone. The positron camera imaged uptake of 62 Zn-histidine in the prostate of a dog at 20 h. 64 Cu was chelated to asparagine, a requirement of leukemic cells, and administered to lymphoma mice. Uptake in tumor and various tissues was determined and compared with the uptake of 67 Ga citrate under the same conditions. 64 Cu-asparagine had better tumor-to-soft tissue ratios than 67 Ga-citrate

  9. Self-reported smoking cessation activities among Swiss primary care physicians

    Directory of Open Access Journals (Sweden)

    Ruffieux Christiane

    2009-03-01

    Full Text Available Abstract Background Individual counselling, pharmacotherapy, and group therapy are evidence-based interventions that help patients stop smoking. Acupuncture, hypnosis, and relaxation have no demonstrated efficacy on smoking cessation, whereas self-help material may only have a small benefit. The purpose of this study is to assess physicians' current clinical practice regarding smokers motivated to stop smoking. Methods The survey included 3385 Swiss primary care physicians. Self-reported use of nine smoking cessation interventions was scored. One point was given for each positive answer about practicing interventions with demonstrated efficacy, i.e. nicotine replacement therapy, bupropion, counselling, group therapy, and smoking cessation specialist. No points were given for the recommendation of acupuncture, hypnosis, relaxation, and self-help material. Multivariable logistic analysis was performed to identify factors associated with a good practice score, defined as ≥ 2. Results The response rate was 55%. Respondents were predominately over the age of 40 years (88%, male (79%, and resided in urban areas (74%. Seventeen percent reported being smokers. Most of the physicians prescribed nicotine replacement therapy (84%, bupropion (65%, or provided counselling (70%. A minority of physicians recommended acupuncture (26%, hypnosis (8%, relaxation (7%, or self-help material (24%. A good practice score was obtained by 85% of respondents. Having attended a smoking cessation-training program was the only significant predictor of a good practice score (odds ratio: 6.24, 95% CI 1.95–20.04. Conclusion The majority of respondents practice recommended smoking cessation interventions. However, there is room for improvement and implementing an evidence-based smoking cessation-training program could provide additional benefit.

  10. A quality enhancement green strategy for broiler meat by application of turmeric (Curcuma longa powder as litter amendment to affect microbes, ammonia emission, pH and moisture

    Directory of Open Access Journals (Sweden)

    K.G.S.C. Katukurunda

    2016-10-01

    Full Text Available In multi-cultural Sri Lankan conditions, poultry meat is paramount importance in ensuring food security and improving nutrition. Issues as contact dermatitis and ammonia emission in broiler industry which caused by diminished litter parameters cause reduction of meat quality, profits and environmental conditions. Therefore use of Turmeric (Curcuma longa (TM powder as an antiseptic litter amendment at several application levels to enhance litter parameters with microbial demolition was attempted. Three months old broiler litter (2 kg sample was taken and initial pH and moisture was determined. Turmeric was used to mix at levels of 0%, 1%, 3%, 5% and 8% (w/w. After mixing, 150 g of mixed litter was placed in container for each level of the 4 replicates, incubated for 5h and analyzed for Total Plate Count (TPC, Yeast and Mold Count (YMC, total Nematode Count (NC, ammonia emission, pH and moisture. Significant reduction (p <0.05 of total bacteria was seen (20%, 46%, 95% and 96% when 1%, 3%, 5% and 8% applications of TM. The YMC reduction was also significant (p <0.05 (34%, 41%, 55% and 65%. Total nematode reduction (p <0.05 was 22%, 45%, 62.5% and 70%. A significant (p <0.05 pH reduction with increment of TM also seen (0.1, 2, 3 and 3%. Moisture (% was increased (p <0.05 (6, 0.78, 19 and 1%. Ammonia emission was significantly decreased (p <0.05 by increased TM (64, 68, 73 and 84% against control. It was concluded that the bacterial, fungal, nematode counts, pH and Ammonia emission of broiler litter can be significantly reduced with the application of 8% (w/w of turmeric powder.

  11. Carcinoma escamocelular bucal diagnosticado precozmente Oral squamocellular carcinoma with early diagnosis

    Directory of Open Access Journals (Sweden)

    Leandro Napier de Souza

    2010-09-01

    Full Text Available El carcinoma escamocelular es la neoplasia maligna más común en la cavidad bucal. Los sitios anatómicos más frecuentemente afectados son el labio inferior, los bordes laterales de lengua y el suelo de la boca. Su etiología es multifactorial, aunque está íntimamente relacionada con factores ambientales como el tabaquismo y el alcoholismo. El cuadro clínico se caracteriza generalmente por la presencia de placas blancas, placas eritematosas, placas entre eritematosas y blancas, úlceras de bordes levantados y masas exofíticas. El tratamiento consiste en la extirpación quirúrgica, la radioterapia, quimioterapia o ambos tratamientos. Este artículo presenta un caso de carcinoma escamocelular bucal en un paciente del sexo masculino, de 70 años de edad. En el mismo se describen los hallazgos clínicos, histopatológicos y el tratamiento correspondiente del caso. El diagnóstico precoz y correcto posibilitó la cura en este caso.The squamocellular carcinoma is a malignant neoplasm commonest in the buccal cavity. The more frequently involved anatomical sites are the lower lip, the tongue's lateral edges and the mouth floor. Its etiology is multifactor although it is closely related to smoking and alcoholism. Clinical picture is generally characterized by the presence of different types of white, erythematous, between erythematous and white plaques, ulcers with raised edges and exophytic masses. Treatment includes surgical removal, radiotherapy, chemotherapy or both. In present paper the case of a man aged 70 presenting with buccal squamous carcinoma describing the clinical, and the histopathologic findings and its corresponding treatment. The early and appropriate diagnosis allowed the cure of this case.

  12. Well-known surface and extracellular antigens of pathogenic microorganisms among the immunodominant proteins of the infectious microalgae Prototheca zopfii.

    Science.gov (United States)

    Irrgang, Alexandra; Murugaiyan, Jayaseelan; Weise, Christoph; Azab, Walid; Roesler, Uwe

    2015-01-01

    Microalgae of the genus Prototheca (P.) are associated with rare but severe infections (protothecosis) and represent a potential zoonotic risk. Genotype (GT) 2 of P. zopfii has been established as pathogenic agent for humans, dogs, and cattle, whereas GT1 is considered to be non-pathogenic. Since pathogenesis is poorly understood, the aim of this study was to determine immunogenic proteins and potential virulence factors of P. zopfii GT2. Therefore, 2D western blot analyses with sera and isolates of two dogs naturally infected with P. zopfii GT2 have been performed. Cross-reactivity was determined by including the type strains of P. zopfii GT2, P. zopfii GT1, and P. blaschkeae, a close relative of P. zopfii, which is known to cause subclinical forms of bovine mastitis. The sera showed a high strain-, genotype-, and species-cross-reactivity. A total of 198 immunogenic proteins have been analyzed via MALDI-TOF MS. The majority of the 86 identified proteins are intracellularly located (e.g., malate dehydrogenase, oxidoreductase, 3-dehydroquinate synthase) but some antigens and potential virulence factors, known from other pathogens, have been found (e.g., phosphomannomutase, triosephosphate isomerase). One genotype-specific antigen could be identified as heat shock protein 70 (Hsp70), a well-known antigen of eukaryotic pathogens with immunological importance when located extracellularly. Both sera were reactive to glyceraldehyde-3-phosphate-dehydrogenase of all investigated strains. This house-keeping enzyme is found to be located on the surface of several pathogens as virulence factor. Flow-cytometric analysis revealed its presence on the surface of P. blaschkeae.

  13. Well-known surface and extracellular antigens of pathogenic microorganisms among the immunodominant proteins of the infectious microalgae Prototheca zopfii

    Directory of Open Access Journals (Sweden)

    Alexandra eIrrgang

    2015-09-01

    Full Text Available Microalgae of the genus Prototheca (P. are associated with rare but severe infections (protothecosis and represent a potential zoonotic risk. Genotype (GT 2 of P. zopfii has been established as pathogenic agent for humans, dogs and cattle, whereas GT1 is considered to be non-pathogenic. Since pathogenesis is poorly understood, the aim of this study was to determine immunogenic proteins and potential virulence factors of P. zopfii GT2. Therefore, 2D western blot analyses with sera and isolates of two dogs naturally infected with P. zopfii GT2 have been performed. Cross-reactivity was determined by including the type strains of P. zopfii GT2, P. zopfii GT1 and P. blaschkeae, a close relative of P. zopfii, which is known to cause subclinical forms of bovine mastitis. The sera showed a high strain-, genotype-, and species-cross-reactivity. A total of 198 immunogenic proteins have been analysed via MALDI- TOF MS. The majority of the 86 identified proteins are intracellularly located (e.g. malate dehydrogenase, oxidoreductase, 3-dehydroquinate synthase but some antigens and potential virulence factors, known from other pathogens, have been found (e.g. phosphomannomutase, triosephosphate isomerase. One genotype-specific antigen could be identified as heat shock protein 70 (Hsp70, a well-known antigen of eukaryotic pathogens with immunological importance when located extracellularly. Both sera were reactive to glyceraldehyde-3-phosphate-dehydrogenase of all investigated strains. This house-keeping enzyme is found to be located on the surface of several pathogens as virulence factor. Flow-cytometric analysis revealed its presence on the surface of P. blaschkeae.

  14. Presentación atípica de piomiositis tropical difusa de psoas por Staphylococcus aureus meticilino resistente Atypical presentation of diffuse tropical pyomiositis of the psoas due to methicillin resistant Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Ray Ticse

    2012-03-01

    Full Text Available La piomiositis tropical difusa primaria es una enfermedad de presentación infrecuente en nuestro medio, con pocos casos asociados a Staphylococcus aureus meticilino resistente, adquirido en la comunidad (MRSA-AC. Se presenta el caso de un paciente de 70 años, con tratamiento irregular para diabetes mellitus tipo 2, que fue hospitalizado por presentar un cuadro de diez días de evolución, con dolor lumbar irradiado a miembro inferior izquierdo, fiebre y flexión forzada de la cadera derecha por dolor a la movilización. El diagnóstico de piomiositis difusa de ambos psoas se realizó con resonancia magnética. Del cultivo de una colección paravertebral posterior se aisló Staphylococcus aureus resistente a oxacilina, penicilina y dicloxacilina.Diffuse tropical primary pyomyositis is an infrequent entity in our country, with few cases associated to communityacquired Methicillin- resistant Staphylococcus aureus. There are no reported cases of Community-Acquired Methicillin- Resistant Staphylococcus aureus (CA- MRSA in Peru. We present the case of a 70 year old male with a previous diagnosis of type 2 diabetes mellitus, receiving irregular treatment, who was admitted to the hospital with a history of 10 days of low back pain radiating to the left leg, fever and forced flexion of the right hip due to pain during movement. The diagnosis of diffuse pyomyositis of both psoas muscles was performed with MRI and culture of a posterior paravertebral collection, from which Staphylococcus aureus resistant to oxacillin, penicillin and dicloxacillin was isolated.

  15. Dimerization site 2 of the bacterial DNA-binding protein H-NS is required for gene silencing and stiffened nucleoprotein filament formation.

    Science.gov (United States)

    Yamanaka, Yuki; Winardhi, Ricksen S; Yamauchi, Erika; Nishiyama, So-Ichiro; Sowa, Yoshiyuki; Yan, Jie; Kawagishi, Ikuro; Ishihama, Akira; Yamamoto, Kaneyoshi

    2018-06-15

    The bacterial nucleoid-associated protein H-NS is a DNA-binding protein, playing a major role in gene regulation. To regulate transcription, H-NS silences genes, including horizontally acquired foreign genes. Escherichia coli H-NS is 137 residues long and consists of two discrete and independent structural domains: an N-terminal oligomerization domain and a C-terminal DNA-binding domain, joined by a flexible linker. The N-terminal oligomerization domain is composed of two dimerization sites, dimerization sites 1 and 2, which are both required for H-NS oligomerization, but the exact role of dimerization site 2 in gene silencing is unclear. To this end, we constructed a whole set of single amino acid substitution variants spanning residues 2 to 137. Using a well-characterized H-NS target, the slp promoter of the glutamic acid-dependent acid resistance (GAD) cluster promoters, we screened for any variants defective in gene silencing. Focusing on the function of dimerization site 2, we analyzed four variants, I70C/I70A and L75C/L75A, which all could actively bind DNA but are defective in gene silencing. Atomic force microscopy analysis of DNA-H-NS complexes revealed that all of these four variants formed condensed complexes on DNA, whereas WT H-NS formed rigid and extended nucleoprotein filaments, a conformation required for gene silencing. Single-molecule stretching experiments confirmed that the four variants had lost the ability to form stiffened filaments. We conclude that dimerization site 2 of H-NS plays a key role in the formation of rigid H-NS nucleoprotein filament structures required for gene silencing. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  16. Production of high-power CW UV by resonant frequency quadrupling of a Nd:YLF laser

    International Nuclear Information System (INIS)

    Kuczewski, A.J.; Thorn, C.E.

    1999-01-01

    The authors have constructed a single ring to resonantly double an 18 watt Nd:YLF mode-locked laser and re-double the stored green to produce over 4 watts of power in the ultra-violet (UV). This laser is used to produce a beam of 470 MeV gamma-rays by Compton backscattering the laser beam from 2.8 GeV electrons stored in a synchrotron. Achieving high luminosity of the colliding beams requires very good mode quality and beam stability at the intersection point 22 meters from the laser. The ring consists of six mirrors, with two 25 cm radius of curvature mirrors enclosing each nonlinear crystal. The drive laser is a lamp-pumped Nd:YLF with a 50 ps bunch length at 76 MHz. A pointing stabilizer servo has been constructed as part of the infrared (IR) mode matching telescope. The IR to green conversion is accomplished in a 15 mm long non-critically phased matched LBO crystal located at a 40 micron waist, with an IR conversion efficiency of 70%. A stable, nearly diffraction limited UV beam of up to 4.2 watts is generated in a BBO crystal in the green storage ring. The output power is relatively independent of the efficiency of the LBO and BBO crystals. This fact makes it possible to reduce the amount of non-TEM 00 modes created by walk-off of the UV by using relatively thin BBO crystals. At present, however, the lower bound on the BBO thickness is limited by the loss of conversion efficiency at high power

  17. In Vitro Restoration of an Amyloid-Beta Altered Network Circuitry in a 'Mutated Biomimetic Acetylcholinesterase' Memristor/Memcapacitor Neural Prosthesis

    Directory of Open Access Journals (Sweden)

    John THORNTON

    2015-08-01

    Full Text Available Many diseases involve the ysregulation of acetylcholinesterase (ACHE causing inappropriate production of the neurotransmitter acetylcholine (ACH. Study of how the ACH actually restores a life threatening neural circuitry damage will provide valuable information for study Alzhermer’s disease. An artificial neuronal device was developed with nanostructured biomimetic mutated ACHE gorge membrane on gold chips having memristor/memcapacitor’s characteristics, served as a model for damaged brain circuitry prosthesis, compared before and after ACH treatments, for in vitro evaluation of the memory restoration in the presence of Amyloid-beta (Ab under the conditions of free from tracers and antibodies in NIST human serum. The results are presented in three categories in “Energy-Sensory” images. Before ACH treatments, images showed four stages of circuitry damages from non symptomatic to life threatening. After a 15 nM ACH treatment, the circuitry was restored due to the ACH removed Pathological High Frequency Oscillation (pHFO center during Slow- Waving Sleeping (SWS. After the prosthesis increased hydrophobicity, the High Frequency Oscillation (HFO was created. Results were compared between the recovered and the “normal brain”: 0.14 vs. 0.47 pJ/bit/µm3 for long-term and 14.0 vs.7.0 aJ/bit/µm3 for short-term memory restoration, respectively. The ratio of Rmax/Rmin value is 6.3-fold higher after the treatment of ACH compared without the treatment in the presence of Ab and the reentry sensitivity increased by 613.8- fold.

  18. Caracterização biométrica, física e química de frutos da palmeira bocaiuva Acrocomia aculeata (Jacq Lodd

    Directory of Open Access Journals (Sweden)

    Eliana Janet Sanjinez-Argandoña

    2011-09-01

    Full Text Available Frutos de palmeira bocaiuva (Acrocomia aculeata (Jacq. Lodd., coletados em Dourados (MS e Presidente Epitácio (SP, foram analisados quanto ao aspecto biométrico, a composição química e as características físicas, visando a avaliar seu potencial alimentício. Os frutos de bocaiuva das regiões de procedência não apresentaram diferenças significativas entre si nas características biométricas. O rendimento médio da polpa foi de 42% em relação ao fruto inteiro, sendo superior ao encontrado na literatura para outros frutos de palmeiras. As determinações físicas e químicas da polpa dos frutos das regiões de Mato Grosso do Sul e São Paulo caracterizam a polpa como sendo pouco ácida (pH 5,70 a 6,29. As amostras de Dourados - MS, foram consideradas mais doces (14,53% de açúcares redutores totais e com maior teor de vitamina C (34,57 mg.100 g-1 em relação às amostras de Presidente Epitácio-SP (11,46 mg.100 g-1. Porém, a intensidade da cor amarelo-laranja foi maior na polpa dos frutos de Presidente Epitácio (SP, sugerindo maior conteúdo de carotenoides.

  19. O ponto de vendas de produtos de luxo da moda de vestuário feminino no Brasil

    Directory of Open Access Journals (Sweden)

    Ricardo Rocha Leal Gomes de Sá

    Full Text Available Este artigo procura identificar como os pontos de vendas de produtos de luxo da moda de vestuário e acessórios estão configurados no Brasil. Com esse objetivo, aborda aspectos como a apresentação externa das lojas, o seu ambiente interno, o atendimento, as práticas de vendas e de manutenção dos clientes, o crédito, as embalagens e pacotes, além dos serviços adicionais. O estudo está fundamentado em pesquisa exploratória com técnicas qualitativas de coleta e análise de dados. Foram entrevistados executivos e gerentes de lojas das empresas que detêm as marcas Fit, Andréa Saletto, Permanente e Marina Rinaldi, instaladas na cidade de São Paulo. Constatou-se que o ponto de vendas é um recurso essencial para esse negócio e que o relacionamento pessoal vendedor/cliente é indispensável para as vendas, associado a um conjunto de ações de encantamento que envolvem as vitrines e o ambiente interno. Foi igualmente observado que a hospitalidade resulta da integração entre atividades e recursos internos e, também, que 70% a 80% das vendas são parceladas no cartão de crédito. Além disso, verificou-se que as vendas são concluídas com a sofisticação das embalagens, pacotes e sacolas, além de serviços de ajuste das peças, que se estendem à casa das clientes. Cabe acrescentar que questões relevantes foram suscitadas, como o que seria uma vantagem competitiva entre essas marcas e se as pessoas efetivamente ricas compram à prestação.

  20. Diagnostic Accuracy of the Slump Test for Identifying Neuropathic Pain in the Lower Limb.

    Science.gov (United States)

    Urban, Lawrence M; MacNeil, Brian J

    2015-08-01

    Diagnostic accuracy study with nonconsecutive enrollment. To assess the diagnostic accuracy of the slump test for neuropathic pain (NeP) in those with low to moderate levels of chronic low back pain (LBP), and to determine whether accuracy of the slump test improves by adding anatomical or qualitative pain descriptors. Neuropathic pain has been linked with poor outcomes, likely due to inadequate diagnosis, which precludes treatment specific for NeP. Current diagnostic approaches are time consuming or lack accuracy. A convenience sample of 21 individuals with LBP, with or without radiating leg pain, was recruited. A standardized neurosensory examination was used to determine the reference diagnosis for NeP. Afterward, the slump test was administered to all participants. Reports of pain location and quality produced during the slump test were recorded. The neurosensory examination designated 11 of the 21 participants with LBP/sciatica as having NeP. The slump test displayed high sensitivity (0.91), moderate specificity (0.70), a positive likelihood ratio of 3.03, and a negative likelihood ratio of 0.13. Adding the criterion of pain below the knee significantly increased specificity to 1.00 (positive likelihood ratio = 11.9). Pain-quality descriptors did not improve diagnostic accuracy. The slump test was highly sensitive in identifying NeP within the study sample. Adding a pain-location criterion improved specificity. Combining the diagnostic outcomes was very effective in identifying all those without NeP and half of those with NeP. Limitations arising from the small and narrow spectrum of participants with LBP/sciatica sampled within the study prevent application of the findings to a wider population. Diagnosis, level 4-.

  1. Caracterización de adultos mayores hospitalizados con lesiones traumáticas osteomioarticulares Characterization of aged adults hospitalized due to osteomioarticular traumatic injuries

    Directory of Open Access Journals (Sweden)

    Jorge Tulio Moreno Navarro

    2011-07-01

    Full Text Available Se realizó un estudio descriptivo y transversal de los 109 ancianos ingresados a causa de lesiones traumáticas osteomioarticulares en el Servicio de Ortopedia y Traumatología del Hospital Clinicoquirúrgico Docente "Dr. Ambrosio Grillo Portuondo" de Santiago de Cuba, durante el primer semestre de 2009. Las variables de interés para la investigación incluyeron: edad, sexo, antecedentes patológicos, escala geriátrica de evaluación funcional, tipo de lesión, tratamiento y complicaciones. Se encontró que los pacientes más afectados por tales traumatismos resultaron ser las mujeres y los mayores de 70 años, que la fractura de cadera fue la lesión más común y que a pesar de que solían presentar enfermedades asociadas, eran activos y experimentaban escasas complicaciones.A descriptive and cross-sectional study of 109 elderly hospitalized at Orthopedics and Traumatology Service from "Dr Ambrosio Grillo Portuondo" Teaching Clinical-Surgical Hospital in Santiago de Cuba due to osteomioarticular traumatic injuries was carried out during the first semester of 2009. Interest variables for the research included: age, sex, medical history, geriatric scale of functional assessment, injury type, treatment, and complications. It was found that the patients most affected by such trauma were women and those aged persons over 70 years old. Hip fracture was the most common injury. In spite of having associated diseases, they were active people and barely experienced complications.

  2. Using gene co-expression network analysis to predict biomarkers for chronic lymphocytic leukemia

    Directory of Open Access Journals (Sweden)

    Borlawsky Tara B

    2010-10-01

    Full Text Available Abstract Background Chronic lymphocytic leukemia (CLL is the most common adult leukemia. It is a highly heterogeneous disease, and can be divided roughly into indolent and progressive stages based on classic clinical markers. Immunoglobin heavy chain variable region (IgVH mutational status was found to be associated with patient survival outcome, and biomarkers linked to the IgVH status has been a focus in the CLL prognosis research field. However, biomarkers highly correlated with IgVH mutational status which can accurately predict the survival outcome are yet to be discovered. Results In this paper, we investigate the use of gene co-expression network analysis to identify potential biomarkers for CLL. Specifically we focused on the co-expression network involving ZAP70, a well characterized biomarker for CLL. We selected 23 microarray datasets corresponding to multiple types of cancer from the Gene Expression Omnibus (GEO and used the frequent network mining algorithm CODENSE to identify highly connected gene co-expression networks spanning the entire genome, then evaluated the genes in the co-expression network in which ZAP70 is involved. We then applied a set of feature selection methods to further select genes which are capable of predicting IgVH mutation status from the ZAP70 co-expression network. Conclusions We have identified a set of genes that are potential CLL prognostic biomarkers IL2RB, CD8A, CD247, LAG3 and KLRK1, which can predict CLL patient IgVH mutational status with high accuracies. Their prognostic capabilities were cross-validated by applying these biomarker candidates to classify patients into different outcome groups using a CLL microarray datasets with clinical information.

  3. Facile Synthesis of Cu2O/RGO/Ni(OH)2 Nanocomposite and its Double Synergistic Effect on Supercapacitor Performance

    International Nuclear Information System (INIS)

    Wang, Kun; Zhao, Chongjun; Min, Shudi; Qian, Xiuzhen

    2015-01-01

    ABSTRACT: A nanocomposite for supercapacitor electrode materials was designed and developed by integrating partially disabled Cu 2 O (low specific capacity, but high cycling ability) and Ni(OH) 2 (low cyclability and high specific capacity) in the presence of reduced graphene oxide (RGO) nanosheets. Nanocomposite of Cu 2 O/RGO/Ni(OH) 2 was directly grown on nickel foam (NF) through a facile one-pot hydrothermal process without any other reductant or oxidant, in which nickel foam acted as both a reductant of GO and Ni source, and a substrate for nanocomposite. The resultant Cu 2 O/RGO/Ni(OH) 2 nanocomposites were characterized by X-ray diffraction (XRD), Raman spectroscopy, X-ray photoelectron spectrometer (XPS), field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). The electrochemical performance of the as-synthesized Cu 2 O/RGO/Ni(OH) 2 /NF electrodes were evaluated using cyclic voltammetry (CV), galvanostatic charge-discharge (GCD), and electrochemical impedance spectrometry (EIS) in 6 mol L −1 KOH aqueous solution. This Cu 2 O/RGO/Ni(OH) 2 nanocomposite exhibits superior capacitive performance: high capability (3969.3 mF cm −2 at 30 mA cm −2 , i.e., 923.1 F g −1 at 7.0 A g −1 ), excellent cycling stability (92.4% retention even after 4,000 cycles, for RGO/Ni(OH) 2 /NF, 92.3% after 1,000 cycles), and good rate capacitance (50.3% capacity remaining at 200 mA cm −2 )

  4. Movimentação de cátions em amostras de um Latossolo Vermelho-Amarelo incubadas com duas fontes de cálcio

    Directory of Open Access Journals (Sweden)

    Wadt Paulo Guilherme Salvada

    1999-01-01

    Full Text Available Estudou-se a movimentação de cátions alcalinos e alcalinos terrosos (CAAT em colunas de solo arranjadas com amostras de Latossolo Vermelho-Amarelo, álico, coletadas a profundidade de 0 a 5cm sob dois tipos distintos de cobertura, floresta secundária e grama batatais (Paspalum notatum L., as quais foram superpostas em potes plásticos à amostras do horizonte Bw, da mesma unidade de solo. Aplicaram-se carbonato de cálcio, sulfato de cálcio ou a mistura das duas fontes de cálcio às amostras superficiais, as quais foram colocadas a incubar e depois submetidas a sete aplicações de água destilada, na taxa de 1 volume-poro por semana, durante sete semanas consecutivas. O lixiviado foi recolhido semanalmente e analisado para cálcio, magnésio, potássio e sulfato solúveis. Nos solos, fizeram-se determinações dos teores de cálcio, magnésio e potássio trocáveis, e a determinação da acidez potencial a pH 7,0. A aplicação de sulfato de cálcio favoreceu o processo de lixiviação de potássio e magnésio, enquanto que a aplicação de carbonato de cálcio minimizou a lixiviação. Concluiu-se que a utilização de sulfato de cálcio para a correção da deficiência de cálcio em subsolos ácidos deve ser acompanhada necessariamente da aplicação de carbonato.

  5. Diffuse and focal presentations of brainstem tumors in children: the images and the prognostic value

    International Nuclear Information System (INIS)

    Menor, F.; Canete, A.; Romero, M. J.; Trilles, L.; Carvajal, E.; Marti-Bonmati, L.

    2000-01-01

    To determine whether the presentation of brainstem tumors as diffuse or focal lesions showed any prognostic value in children. A retrospective review was carried out of the neuroradiological findings in 43 children with brainstem tumors, all of whom underwent computed tomography (CT) and 31 of whom underwent magnetic resonance (MR). The diffuse tumors (n=20) were all located in the pons, spreading to mesencephalon in 6 cases and to medulla oblongata in 1, and exhibiting exophytic growth, preferentially to the prepontine cistern. They presented homogeneous low attenuation in CT (90%) and decrease/increased signal intensity in T1/T2-weighted MR images (91.6%). Contrast uptake was observed in 20% of cases, with agreement between CT and MR. The patients showed a good initial response to treatment (70%), a high rate of relapse (80%) and a 5-year survival of 12%. The focal tumors were located in the pons (11 cases, spreading to the medulla oblongata in 2), mesencephalon (11 cases, 9 tectal and 2 peduncular) and medulla oblongata (1 case), and exhibited exophytic growth predominantly to the pontocerebellar junction and to the cerebellar peduncles. They showed a certain tendency toward heterogeneity (21.7%), toward isoattenuation in CT (47.8%) and isointensity in T1-weighted MR images (26.3%). CT showed a rate of tumor uptake of 26%, while the rate of contrast iptake was 58% MR. Fifty percent of these lesions responded well to therapy, with a recurrence rate of 28% and 4-year survival of 63%. Neuroimaging helps to define two basic patterns in brainstem tumors that play a role in prognosis. The diffuse tumor, which characteristically shows a good initial response to therapy, has a worse prognosis, probably reflecting its histological aggressiveness. (Author) 21 refs

  6. 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer

    International Nuclear Information System (INIS)

    Ribeiro, Monica Pires; Souza, Sergio Augusto Lopes de; Lopes, Flavia Paiva Proenca Lobo; Rosado-de-Castro, Paulo Henrique; Fonseca, Lea Mirian Barbosa da; Gutfilen, Bianca

    2013-01-01

    Objective: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of 99m Tc-thymine in mammary lesions. Methods: A total of 45 patients were included in this study. Thirty-three patients (73%) were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results. Results: The majority of patients (64.4%) had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with 99m Tc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively, and an accuracy of 82.2%. Conclusions: The results of this study are consistent with those previously reported by other authors. The good specificity and high negative predictive value of this technique and the absence of uptake in the heart indicate that it may be a promising complementary method in clinical practice and that it may contribute to reducing unnecessary benign biopsies. (author)

  7. Apendicitis aguda en el paciente senil: Factores asociados a una mayor morbimortalidad post operatoria

    Directory of Open Access Journals (Sweden)

    Víctor Eduardo Chian Chang

    1996-04-01

    Full Text Available Objetivo: Definir los factores asociados a una mayor morbilidad y mortalidad en pacientes seniles con apendicitis aguda. Material y métodos: Se realizó un estudio retrospectivo con 100 pacientes intervenidos en el Hospital Nacional Arzobispo Loayza, durante el período comprendido entre 1984 a 1994. Resultados: Se asociaron a una mayor frecuencia de complicaciones postoperatorias: edad mayor o igual a 70 años, tiempo de enfermedad mayor de 48 horas, presencia de apendicitis perforada con peritonitis localizada o generalizada (p<0.05. Además la presencia de apendicitis perforada se asoció significativamente a la presencia de absceso residual y/o fístula estercorácea (p=0.027 y la presencia de AA gangrenosa o perforada a mayor frecuencia de infección de herida operatoria (p<0.05. El antecedente de patología cardiovascular previa se asoció a mayor frecuencia de complicaciones cardiovasculares (p<0.05. Se asociaron a mayor mortalidad en AA, pacientes con intervención quirúrgica adicional a la apendicetomía (p=0.016 y presencia de AA perforada (p=0.027. Conclusiones: Los estadios avanzados de AA, así como la presencia de problema cardiovascular al momento del diagnóstico se asociaron con una mayor frecuencia de complicaciones post-operatorias. La presencia de peritonitis se asocia con la mortalidad. (Rev Med Hered 1996; 7: 62-67.

  8. Frecuencia de errores de los pacientes con su medicación Frequency of medication errors by patients

    Directory of Open Access Journals (Sweden)

    José Joaquín Mira

    2012-02-01

    Full Text Available OBJETIVO: Analizar la frecuencia de errores de medicación que son cometidos e informados por los pacientes. MÉTODOS: Estudio descriptivo basado en encuestas telefónicas a una muestra aleatoria de pacientes adultos del nivel primario de salud del sistema público español. Respondieron un total de 1 247 pacientes (tasa de respuesta, 75%. El 63% eran mujeres y 29% eran mayores de 70 años. RESULTADOS: Mientras 37 pacientes (3%, IC 95%: 2-4 sufrieron complicaciones asociadas a la medicación en el curso del tratamiento, 241 (19,4%, IC 95%: 17-21 informaron haber cometido algún error con la medicación. Un menor tiempo de consulta (P OBJECTIVE: Analyze the frequency of medication errors committed and reported by patients. METHODS: Descriptive study based on a telephone survey of a random sample of adult patients from the primary care level of the Spanish public health care system. A total of 1 247 patients responded (75% response rate; 63% were women and 29% were older than 70 years. RESULTS: While 37 patients (3%, 95% CI: 2-4 experienced complications associated with medication in the course of treatment, 241 (19.4%, 95% CI: 17-21 reported having made some mistake with their medication. A shorter consultation time (P < 0.01 and a worse assessment of the information provided by the physician (P < 0.01 were associated with the fact that during pharmacy dispensing the patient was told that the prescribed treatment was not appropriate. CONCLUSIONS: In addition to the known risks of an adverse event due to a health intervention resulting from a system or practitioner error, there are risks associated with patient errors in the self-administration of medication. Patients who were unsatisfied with the information provided by the physician reported a greater number of errors.

  9. Diffuse and focal presentations of brainstem tumors in children: the images and the prognostic value; Presentacion difusa o focal de los tumores troncoencefalicos en los ninos: imagen y valor pronostico

    Energy Technology Data Exchange (ETDEWEB)

    Menor, F.; Canete, A.; Romero, M. J.; Trilles, L.; Carvajal, E. [Hospital Universitario La Fe. Valencia (Spain); Marti-Bonmati, L. [Hospital Universitario Dr. Peset. Valencia (Spain)

    2000-07-01

    To determine whether the presentation of brainstem tumors as diffuse or focal lesions showed any prognostic value in children. A retrospective review was carried out of the neuroradiological findings in 43 children with brainstem tumors, all of whom underwent computed tomography (CT) and 31 of whom underwent magnetic resonance (MR). The diffuse tumors (n=20) were all located in the pons, spreading to mesencephalon in 6 cases and to medulla oblongata in 1, and exhibiting exophytic growth, preferentially to the prepontine cistern. They presented homogeneous low attenuation in CT (90%) and decrease/increased signal intensity in T1/T2-weighted MR images (91.6%). Contrast uptake was observed in 20% of cases, with agreement between CT and MR. The patients showed a good initial response to treatment (70%), a high rate of relapse (80%) and a 5-year survival of 12%. The focal tumors were located in the pons (11 cases, spreading to the medulla oblongata in 2), mesencephalon (11 cases, 9 tectal and 2 peduncular) and medulla oblongata (1 case), and exhibited exophytic growth predominantly to the pontocerebellar junction and to the cerebellar peduncles. They showed a certain tendency toward heterogeneity (21.7%), toward isoattenuation in CT (47.8%) and isointensity in T1-weighted MR images (26.3%). CT showed a rate of tumor uptake of 26%, while the rate of contrast iptake was 58% MR. Fifty percent of these lesions responded well to therapy, with a recurrence rate of 28% and 4-year survival of 63%. Neuroimaging helps to define two basic patterns in brainstem tumors that play a role in prognosis. The diffuse tumor, which characteristically shows a good initial response to therapy, has a worse prognosis, probably reflecting its histological aggressiveness. (Author) 21 refs.

  10. EXAFS study on the neptunium(V) complexation by various humic acids under neutral pH conditions

    Energy Technology Data Exchange (ETDEWEB)

    Sachs, S.; Schmeide, K.; Brendler, V.; Heise, K.H.; Bernhard, G. [Forschungszentrum Rossendorf e.V., Inst. of Radiochemistry, Dresden (Germany); Reich, T. [Forschungszentrum Rossendorf e.V., Inst. of Radiochemistry, Dresden (Germany); Univ. Mainz, Inst. of Nuclear Chemistry (Germany)

    2005-07-01

    The structure of Np(V) humic acid (HA) complexes at pH 7 was studied by extended X-ray absorption fine structure analysis (EXAFS). For the first time, the influence of phenolic OH groups on the complexation of HA and Np(V) in the neutral pH range was investigated using modified HAs with blocked phenolic OH groups and Bio-Rex70, a cation exchange resin having only carboxyl groups as proton exchanging sites. The formation of Np(V) humate complexes was verified by near-infrared (NIR) spectroscopy. Axial Np-O bond distances of 1.84-1.85 Aa were determined for the studied Np(V) humate complexes and the Np(V)-Bio-Rex70 sorbate. In the equatorial plane Np(V) is surrounded by about 3 oxygen atoms with bond lengths of 2.48-2.49 Aa. The comparison of the structural parameters of the Np(V) humates with those of Np(V)-Bio-Rex70 points to the fact that the interaction between HA and Np(V) in the neutral pH range is dominated by carboxylate groups. However, up to now a contribution of phenolic OH groups to the interaction process cannot be excluded completely. The comparison of the obtained structural data for the Np(V) humates to those of Np(V) carboxylates and Np(V) aquo ions reported in the literature indicates that humic acid carboxylate groups predominantly act as monodentate ligands. A differentiation between equatorial coordinated carboxylate groups and water molecules using EXAFS spectroscopy is impossible. (orig.)

  11. The Structure of Pre-Transitional Protoplanetary Disks. II Azimuthal Asymmetries, Different Radial Distributions of Large and Small Dust Grains in PDS 70

    Science.gov (United States)

    Hashimoto, J.; Tsukagoshi, T.; Brown, J. M.; Dong, R.; Muto, T.; Zhu, Z.; Wisniewski, J.; Ohashi, N.; Kudo, T.; Kusakabe, N.; hide

    2015-01-01

    The formation scenario of a gapped disk, i.e., transitional disk, and its asymmetry is still under debate. Proposed scenarios such as disk-planet interaction, photoevaporation, grain growth, anticyclonic vortex, eccentricity, and their combinations would result in different radial distributions of the gas and the small (sub-micron size) and large (millimeter size) dust grains as well as asymmetric structures in a disk. Optical/near-infrared (NIR) imaging observations and (sub-)millimeter interferometry can trace small and large dust grains, respectively; therefore multi-wavelength observations could help elucidate the origin of complicated structures of a disk. Here we report Submillimeter Array observations of the dust continuum at 1.3 mm and CO-12 J = 2 yields 1 line emission of the pre-transitional protoplanetary disk around the solar-mass star PDS 70. PDS 70, a weak-lined T Tauri star, exhibits a gap in the scattered light from its disk with a radius of approx. 65 AU at NIR wavelengths. However, we found a larger gap in the disk with a radius of approx. 80 AU at 1.3 mm. Emission from all three disk components (the gas and the small and large dust grains) in images exhibits a deficit in brightness in the central region of the disk, in particular, the dust disk in small and large dust grains has asymmetric brightness. The contrast ratio of the flux density in the dust continuum between the peak position to the opposite side of the disk reaches 1.4. We suggest the asymmetries and different gap radii of the disk around PDS 70 are potentially formed by several (unseen) accreting planets inducing dust filtration.

  12. Electronic structure of homoleptic transition metal hydrides: TiH4, VH4, CrH4, MnH4, FeH4, CoH4, and NiH4

    International Nuclear Information System (INIS)

    Hood, D.M.; Pitzer, R.M.; Schaefer III, H.F.

    1979-01-01

    Ab initio molecular electronic structure theory has been applied to the family of transition metal tetrahydrides TiH 4 through NiH 4 . For the TiH 4 molecule a wide range of contracted Gaussian basis sets has been tested at the self-consistent-field (SCF) level of theory. The largest basis, labeled M(14s 11p 6d/10s 8p 3d), H(5s 1p/3s 1p), was used for all members of the series and should yield wave functions approaching true Hartree-Fock quality. Predicted SCF dissociation energies (relative to M+4H) and M--H bond distances are TiH 4 132 kcal, 1.70 A; VH 4 86 kcal, 1.64 A; CrH 4 65 kcal, 1.59 A; MnH 4 -- 36 kcal, 1.58 A; FeH 4 0 kcal, 1.58 A; CoH 4 27 kcal, 1.61 A; and NiH 4 18 kcal, 1.75 A. It should be noted immediately that each of these SCF dissociation energies will be increased by electron correlation effects by perhaps as much as 90 kcal. For all of these molecules except TiH 4 excited states have also been studied. One of the most interesting trends seen for these excited states is the shortening of the M--H bond as electrons are transferred from the antibonding 4t 2 orbital to the nonbonding 1e orbitals

  13. Infiltración extramedular en la leucemia mielomonocítica crónica (LMMC Extramedullary infiltration in chronic myelomonocytic leukemia (CMML

    Directory of Open Access Journals (Sweden)

    Onel Ávila Cabrera

    2008-12-01

    Full Text Available La leucemia mielomonocítica crónica (LMMC constituye un proceso oncohematológico de naturaleza mixta, mieloproliferativa y mielodisplásica. Su forma habitual de presentación es consecuencia, generalmente, de las citopenias en sangre periférica (síndrome anémico, infecciones o diátesis hemorrágica. La infiltración extramedular en la LMMC frecuentemente involucra el bazo, hígado, piel y nódulos linfáticos; sin embargo, es poco frecuente su localización en otros sitios. Se describe un paciente de 70 años con el diagnóstico de LMMC con infiltración extramedular en piel (nódulos subcutáneos, paladar duro y testículos; se comentan aspectos diagnósticos, terapéuticos y evolutivos.Chronic myelomonocytic leukemia is an oncohematological process of mixed, myeloproliferative and myelodisplastic nature. Its habitual form of presentation generally results from cytopenias in peripheral blood (anemic syndrome, infections or hemorrhagic diathesis. The extramedullary infiltration in the CMML frequently involves the spleen, the liver, the skin and the lymphatic nodules; however, its localization in other sites is not usual. The case of a 70-year-old patient with diagnosis of CMML and with extramedullary infiltration in the skin (subcutaneous nodules, hard palate and testicles is described. Comments on diagnostic, therapeutic and evolutive aspects are made

  14. PREVALÊNCIA DA ADEQUAÇÃO À ALIMENTAÇÃO SAUDÁVEL DE IDOSOS RESIDENTES EM ZONA RURAL

    Directory of Open Access Journals (Sweden)

    Sara Franco Diniz Heitor

    2013-01-01

    Full Text Available Las preferencias alimentarias desempeñan un papel importante a lo largo de la vida y en caso sean basadas en elecciones inadecuadas pueden desencadenar enfermedades. Este estudio ha objetivado determinar la prevalencia de la adecuación a la Guía "10 pasos para una alimentación saludable para la persona anciana", además de caracterizar el perfil sociodemográfico económico y antropométrico de 850 ancianos de una zona rural de Uberaba-MG. Inquérito domiciliar, transversal y observacional. La prevalencia de los pasos ha sido colectada con cuestionario de frecuencia y consumo alimentario. El análisis de datos consistió en la distribución de frecuencia simple. La mayoría era del sexo masculino, hasta 70 años, casada, vivía con el cónyuge, baja escolaridad, renta de un sueldo mínimo y eutróficos. Ningún anciano seguía todos los pasos. El paso 8, ingestión de sal, se mostró como el más seguido, por el contrario, el paso 5, consumo de carnes magras y leche, presentó la menor adhesión. Conocer la población y sus hábitos es importante en la implementación de estrategias que mejoren la calidad de vida.

  15. Pediatrician prescriptions for outdoor physical activity among children: A pilot study.

    Science.gov (United States)

    Christiana, Richard W; Battista, Rebecca A; James, Joy J; Bergman, Shawn M

    2017-03-01

    Research indicates that promoting time spent in the outdoors and outdoor physical activity increases children's daily physical activity and improves health. One method showing promise is doctor prescriptions for outdoor physical activity for children; however, no empirical evidence currently exists on prescriptions for children's outdoor physical activity. A pilot study was conducted at one pediatric practice in western North Carolina during 2015 to test the feasibility and potential effectiveness of conducting an outdoor physical activity prescription program for children aged 5-13 years. Three pediatricians wrote prescriptions for children ( n  = 38), discussed benefits of outdoor physical activity, and provided information packets to parents on nearby places for physical activity. Parents of patients of five pediatricians served as control ( n  = 32). Prior to seeing a pediatrician, parents completed a baseline survey that asked height and weight, assessed their views of children's physical activity, and their personal and child's physical activity/sedentary behaviors. A nurse measured children's height and weight. Parents were emailed one-month and three-month follow-up surveys that asked the questions listed above. Changes in children's physical activity, outdoor physical activity, time spent in the outdoors, and sedentary activities were not significant between intervention and control groups. About half of parents (49%) viewed prescriptions as beneficial for their children and most used the intervention materials at home (70%). A larger study is needed to assess whether prescriptions increase children's physical activity. A critical examination of the intervention, pilot study design, and suggestions for a larger future study are provided.

  16. Pediatrician prescriptions for outdoor physical activity among children: A pilot study

    Directory of Open Access Journals (Sweden)

    Richard W. Christiana

    2017-03-01

    Full Text Available Research indicates that promoting time spent in the outdoors and outdoor physical activity increases children's daily physical activity and improves health. One method showing promise is doctor prescriptions for outdoor physical activity for children; however, no empirical evidence currently exists on prescriptions for children's outdoor physical activity. A pilot study was conducted at one pediatric practice in western North Carolina during 2015 to test the feasibility and potential effectiveness of conducting an outdoor physical activity prescription program for children aged 5–13 years. Three pediatricians wrote prescriptions for children (n = 38, discussed benefits of outdoor physical activity, and provided information packets to parents on nearby places for physical activity. Parents of patients of five pediatricians served as control (n = 32. Prior to seeing a pediatrician, parents completed a baseline survey that asked height and weight, assessed their views of children's physical activity, and their personal and child's physical activity/sedentary behaviors. A nurse measured children's height and weight. Parents were emailed one-month and three-month follow-up surveys that asked the questions listed above. Changes in children's physical activity, outdoor physical activity, time spent in the outdoors, and sedentary activities were not significant between intervention and control groups. About half of parents (49% viewed prescriptions as beneficial for their children and most used the intervention materials at home (70%. A larger study is needed to assess whether prescriptions increase children's physical activity. A critical examination of the intervention, pilot study design, and suggestions for a larger future study are provided.

  17. The effect of optimal medical therapy on 1-year mortality after acute myocardial infarction.

    Science.gov (United States)

    Bramlage, P; Messer, C; Bitterlich, N; Pohlmann, C; Cuneo, A; Stammwitz, E; Tebbenjohanns, J; Gohlke, H; Senges, J; Tebbe, U

    2010-04-01

    Five drug classes have been shown to improve the prognosis of acute myocardial infarction in clinical trials: aspirin, beta-blockers, statins, renin angiotensin system (RAS) blockers and thienopyridines. We aimed to assess whether the benefits of combining these drugs (termed optimal medical therapy, OMT), will result in a reduction of mortality in clinical practice. Nationwide registry Hospitals with a cardiology unit or internal medicine department. 5353 patients with acute myocardial infarction. At hospital discharge 89% received aspirin, 90% beta-blockers, 84% statins, 81% RAS blockers, 70% a thienopyridine and 46.2% OMT. Pharmacotherapy OR with 95% CI for mortality from myocardial infarction were calculated and adjusted for patient risk at baseline. Total mortality was reduced by 74% in patients receiving OMT (adj OR 0.26; 95% CI 0.18 to 0.38) versus patients receiving one or no drug. This was consistent in subgroups defined by STEMI/NSTEMI, diabetes and gender. Mortality was also reduced in patients receiving 2-4 drugs (adj OR 0.49; 95% CI 0.35 to 0.68), diabetic patients being the only subgroup with no significant effect. Analyses on the relative importance of either component revealed that withdrawal of beta-blockers (adj OR 0.63; 95% CI 0.34 to 1.16) and/or a combination of aspirin/clopidogrel (adj OR 0.59; 95% CI 0.20 to 1.17) abolished the risk reduction conferred by OMT. OMT over 1 year was associated with a significantly lower mortality of patients with acute myocardial infarction in clinical practice. However OMT is provided to less than half of eligible patients leaving room for substantial improvement.

  18. The gridless plasma ion source (GIS) for plasma ion assisted optical coating

    International Nuclear Information System (INIS)

    You Dawei; Li Xiaoqian; Wang Yu; Lin Yongchang

    2004-01-01

    High-quality optical coating is a key technology for modern optics. Ion-assisted deposition technology was used to improve the vaporized coating in 1980's. The GIS (gridless ion source), which is an advanced plasma source for producing a high-quality optical coating in large area, can produce a large area uniformity>1000 mm (diameter), a high ion current density ∼0.5 mA/cm 2 , 20 eV-200 eV energetic plasma ions and can activate reactive gas and film atoms. Now we have developed a GIS system. The GIS and the plasma ion-assisted deposition technology are investigated to achieve a high-quality optical coating. The GIS is a high power and high current source with a power of 1 kW-7.5 kW, a current of 10 A- 70 A and an ion density of 200 μA/cm 2 -500 μA/cm 2 . Because of the special magnetic structure, the plasma-ion extraction efficiency has been improved to obtain a maximum ion density of 500 μA/cm 2 in the medium power (∼4 kW) level. The GIS applied is of a special cathode structure, so that the GIS operation can be maintained under a rather low power and the lifetime of cathode will be extended. The GIS has been installed in the LPSX-1200 type box coating system. The coated TiO 2 , SiO 2 films such as antireflective films with the system have the same performance reported by Leybold Co, 1992, along with a controllable refractive index and film structure. (authors)

  19. Evaluation of Managerial Needs for Palliative Care Centers: Perspectives of Medical Directors.

    Science.gov (United States)

    Kafadar, Didem; Ince, Nurhan; Akcakaya, Adem; Gumus, Mahmut

    2015-01-01

    Palliative therapies have an important role in increasing the quality of healthcare and in dealing with physical and psychosocial problems due to cancer. We here aimed to evaluate the managerial perspectives and opinions of the hospital managers and clinical directors about specialized palliative care centers. This study was conducted in two large-scale hospitals in which oncology care is given with medical directors (n:70). A questionnaire developed by the researchers asking about demographic characteristics and professional experience, opinions and suggestions of medical directors about providing and integrating palliative care into healthcare was used and responses were analyzed. Potential barriers in providing palliative care (PC) and integrating PC into health systems were perceived as institutional by most of the doctors (97%) and nurses (96%). Social barriers were reported by 54% of doctors and 82% of nurses. Barriers due to interest and knowledge of health professionals about PC were reported by 76% of doctors and 75% of nurses. Among encouragement ideas to provide PC were dealing with staff educational needs (72%), improved working conditions (77%) and establishing a special PC unit (49)%. An independent PC unit was suggested by 27.7% of participants and there was no difference between the hospitals. To overcome the barriers for integration of PC into health systems, providing education for health professionals and patient relatives, raising awareness in society, financial arrangements and providing infrastructure were suggested. The necessity for planning and programming were emphasized. In our study, the opinions and perspectives of hospital managers and clinical directors were similar to current approaches. Managerial needs for treating cancer in efficient cancer centers, increasing the capacity of health professionals to provide care in every stage of cancer, effective education planning and patient care management were emphasized.

  20. The First Paenibacillus larvae Bacteriophage Endolysin (PlyPl23) with High Potential to Control American Foulbrood.

    Science.gov (United States)

    Oliveira, Ana; Leite, Marta; Kluskens, Leon D; Santos, Sílvio B; Melo, Luís D R; Azeredo, Joana

    2015-01-01

    Endolysins, which are peptidoglycan-degrading enzymes expressed during the terminal stage of the reproduction cycle of bacteriophages, have great potential to control Gram-positive pathogens. This work describes the characterization of a novel endolysin (PlyPl23) encoded on the genome of Paenibacillus larvae phage phiIBB_Pl23 with high potential to control American foulbrood. This bacterial disease, caused by P. larvae, is widespread in North America and Europe and causes important economic losses in apiculture. The restriction to antibiotic residues in honey imposed by the EU legislation hinders its therapeutic use to combat American foulbrood and enforces the development of alternative antimicrobial methods. The new endolysin described herein has an N-acetylmuramoyl-L-alanine amidase catalytic domain and exhibits a broad-spectrum activity against common P. larvae genotypes. Moreover, the enzyme displays high antimicrobial activity in a range of pH that matches environmental conditions (pH between 5.0 and 7.0), showing its feasible application in the field. At pH 7.0, a concentration of 0.2 μM of enzyme was enough to lyse 104 CFU.mL-1 of P. larvae in no more than 2 h. The presence of sucrose and of the substances present in the larvae gut content did not affect the enzyme activity. Interestingly, an increase of activity was observed when PlyPl23 was previously incubated in royal jelly. Furthermore, in vivo safety evaluation assays demonstrated that this enzyme is not toxic to the bee larvae. The present work describes for the first time an endolysin encoded in a P. larvae phage that presents high potential to integrate a commercial product to control the problematic American foulbrood.

  1. Restricted diffusion of CrEDTA and cyanocobalamine across the exchange vessels in rat hindquarters.

    Science.gov (United States)

    Haraldsson, B; Rippe, B

    1986-07-01

    The degree of diffusional restriction of skeletal muscle capillary walls to small solutes was estimated from the permeability surface area products (PS) of CrEDTA (MW = 341) and cyanocobalamine (MW = 1355), using computerized 'on-line' recordings of venous single injection indicator dilution curves. Experiments were performed on isolated perfused maximally vasodilated rat hindquarters during largely isogravimetric conditions and the arrangements allowed for measurements of capillary filtration coefficients (CFC). Extraction of tracer varied markedly as a function of transit time and, furthermore, PS increased with increasing flows, both these phenomena indicating tissue and flow heterogeneity. At maximal flows the disturbing influence of heterogeneity will be minimal and hence the diffusion capacities obtained by extrapolating PS area to infinite flows, so called PS tot values, were considered to give the best estimation of the 'true' capillary diffusion capacities. The value of PS tot was 12.9 +/- 0.5 for CrEDTA and 5.1 +/- 0.3 ml min-1 per 100 g for vitamin B12. The calculated PS tot ratio of 2.59 +/- 0.11 indicates restricted diffusion through equivalent pores of radius 53 A, whereas the ratio of the free diffusion coefficients for these solutes is 1.79. Using PS peak for the calculations (totally neglecting heterogeneity) the pore radius was, however, markedly overestimated. Thus, for a PS-ratio of 1.89 +/- 0.04 for CrEDTA vs. B12 an equivalent pore radius of 300 A was calculated. Also, using PS area (only partly correcting for heterogeneity) overestimated the pore radius (70 A) from a mean PS-ratio of 2.33 +/- 0.05. It was concluded that the equivalent pore radius in rat hindquarter microvascular walls is 53 A or even smaller in essential agreement with data from osmotic transient experiments in the same preparation (r approximately 40 A).

  2. Efectos a corto plazo de la contaminación atmosférica sobre la mortalidad: resultados del proyecto EMECAM en Vitoria-Gasteiz, 1990-94

    Directory of Open Access Journals (Sweden)

    Pérez Boillos María José

    1999-01-01

    Full Text Available FUNDAMENTO: El objetivo de este trabajo es evaluar la asociación a corto plazo entre los niveles de humos negros (HN y SO2 y la mortalidad en Vitoria-Gasteiz para un período de cinco años, mediante la aplicación de la metodología de análisis estandarizada del proyecto EMECAM. MÉTODOS: Estudio ecológico de series temporales que trata de estimar la asociación entre las variaciones diarias de mortalidad (mortalidad total en todas las edades y mortalidad total en mayores de 70 años, y contaminación atmosférica (dióxido de azufre-SO2 y humos negros, utilizando modelos de regresión de Poisson. Se siguió la metodología EMECAM. RESULTADOS: La mediana de muertes diarias fue de tres en el total de la población y de dos en ancianos. El nivel medio de humos negros fue 51,15 m g/m³ y el de SO2 18,04 m g/m³. Se encontró una asociación estadísticamente significativa entre humos negros y mortalidad en ancianos durante el semestre frío, con un RR de 1,014 (IC 95%: 1,002-1,026, correspondiente a un incremento de 10 m g/m³ del contaminante. Parecía detectarse un umbral en 80-90m g/m³ de humos negros. La asociación con SO2 no fue significativa. CONCLUSIONES: Los niveles de humos negros del período estudiado se asocian a un incremento en la mortalidad en ancianos, coincidiendo con el resultado de otros estudios.

  3. Growth Conditions and Gamma-Irradiation as Enhancers of Cellulase Production by Bacillus subtilis Using Solid State Fermentation of Banana Wastes

    International Nuclear Information System (INIS)

    EI Shafey, H.M.

    2008-01-01

    In the present investigation trials have been carried out to study the effect of growth conditions and y-irradiation on the enhancement of cellulases using banana wastes. Bacterial strains were isolated from degraded banana wastes. Using the plate screening medium, a hypercelIulolytic isolate was selected on the basis of the diameter of the hydrolysis zone surrounding the colonies, and identified as Bacillus subtilis. Three method of pretreatment or the substrate were applied and compared in order to increase the susceptibility of the substrate to biodegradation. The methods used were autoclaving at 121 degree C for 60 min, acid hydrolysis using 2 N HCI, and alkali hydrolysis using 2 M NaOH. Pretreatment of the substrate (banana wastes) by autoclaving at 121 degree C for 60 minutes yielded the highest carboxymethyl cellulase (CMCase) and filter paper cellulase (FPase) enzyme activities in comparing with other methods. Production of CMCase and FPase was followed during changes of the growth conditions using solid state fermentation. Results showed that the two enzymes share the same growth factors for the maximum enzymatic production including 36 degree C incubation temperature, 72 hours incubation period, 60% moisture content, 20% v/w inoculum size, and initial ph 7.0. A gamma irradiation dose of 1.5 kGy was found to have an enhancing effect on the two enzymes production. Production of FPase enzyme was enhanced by 3.43 and 2.28% in pseudo stems and leaves, respectively. On the other hand, production of CMCase enzyme was slightly enhanced by 0.91 and 0.72% using pseudo stems and leaves respectively. Results also showed that banana leaves yielded higher CMCase and FPase enzymes than pseudo stems

  4. Development of positron emitting radionuclides for imaging with improved positron detectors. [/sup 82/Rb, /sup 62/Zn, /sup 64/Cu, /sup 67/Ga

    Energy Technology Data Exchange (ETDEWEB)

    Yano, Y.

    1976-10-01

    Recent advances in positron cameras and positron ring detectors for transverse section reconstruction have created renewed interest in positron emitting radionuclides. This paper reports on: generator-produced /sup 82/Rb; cyclotron-produced /sup 62/Zn; and reactor-produced /sup 64/Cu. Investigation of the /sup 82/Sr (25 d)--/sup 82/Rb (75 s) generator determined the elution characteristics for Bio-Rex 70, a weakly acidic carboxylic cation exchanger, using 2% NaCl as the eluent. The yield of /sup 82/Rb and the breakthrough of /sup 82/Sr were determined for newly prepared columns and for long term elution conditions. Spallation-produced /sup 82/Sr was used to charge a compact /sup 82/Rb generator to obtain multi-millicurie amounts of /sup 82/Rb for myocardial imaging. Zinc accumulates in the islet cells of the pancreas and in the prostate. Zinc-62 was produced by protons on Cu foil and separated by column chromatography. Zinc-62 was administered as the amino acid chelates and as the ZnCl/sub 2/ to tumor and normal animals. Tissue distribution was determined for various times after intravenous injection. Pancreas-liver images of /sup 62/Zn-histidine uptake were obtained in animals with the gamma camera and the liver uptake of /sup 99m/Tc sulfur colloid was computer subtracted to image the pancreas alone. The positron camera imaged uptake of /sup 62/Zn-histidine in the prostate of a dog at 20 h. /sup 64/Cu was chelated to asparagine, a requirement of leukemic cells, and administered to lymphoma mice. Uptake in tumor and various tissues was determined and compared with the uptake of /sup 67/Ga citrate under the same conditions. /sup 64/Cu-asparagine had better tumor-to-soft tissue ratios than /sup 67/Ga-citrate.

  5. Influence of aging on the quality of the skin of white women: the role of collagen Influência do envelhecimento na qualidade da pele de mulheres brancas: o papel do colágeno

    Directory of Open Access Journals (Sweden)

    Eloina do Rocio Valenga Baroni

    2012-10-01

    Full Text Available PURPOSE: Evaluate the influence of aging on the quality of the skin of white women, analyzing the dermal collagen. METHODS: Pre-auricular flaps were collected for histological and morphometric analysis of 218 white women who underwent spontaneous facial aesthetic plastic surgery. Picrosirius ultrared stain was used for analysis and quantification of collagen in five age groups (OBJETIVO: Avaliar a influência do envelhecimento na qualidade da pele de mulheres brancas analisando o colágeno dérmico. MÉTODOS: Realizou-se análise histológica e morfométrica de 218 retalhos pré-auriculares de mulheres brancas que se submeteram espontaneamente à cirurgia estética facial. Foi usada a coloração de Picrosirius Ultrared para analisar e quantificar os colágenos I, III e total em cinco grupos etários (<40 anos, 40 a 49 anos, 50 a 59 anos, 60 a 69 anos e 70 a 79 anos. RESULTADOS: A análise histológica mostrou alterações sugestivas de envelhecimento cutâneo (fragmentação e desorganização das fibras de colágeno, especialmente em pacientes acima de 60 anos. Não houve diferenças significantes entre a idade e a espessura da derme e da epiderme, mas houve diferenças significantes entre as percentagens de colágeno I, III e total (p<0,001 com o aumento da idade. CONCLUSÃO: Existe redução do colágeno com o aumento da idade e um aumento na sua degradação, levando à fragmentação das fibras.

  6. The Bocono Fault Zone, Western Venezuela

    Energy Technology Data Exchange (ETDEWEB)

    Schubert, C. (I.V.I.C., Caracas (Venezuela)); Estevez, R. (Universidad de los Andes, Merida (Venezuela)); Henneberg, H.G. (Universidad del Zulia, Maracaibo (Venezuela))

    1993-02-01

    The Bocono Fault Zone, the western part of the Bocono Moron-El Pilar Fault System of the southern Caribbean plate boundary, consists of aligned valleys, linear depressions, pull-apart basins and other morphological features, which extend for about 500 km in a N45[degrees]E direction, between the Tachira depression (Venezuela-Colombia border) and the Caribbean Sea. It crosses obliquely the Cordillera de Merida and cuts across the Caribbean Mountains, two different geologic provinces of Late Tertiary-Quaternary and Late Cretaceous-Early Tertiary age, respectively. Therefore, the maximum age that can be assigned to the Bocono Fault Zone is Late Tertiary (probably Pliocene). A total maximum right-lateral offset rate of 3.3 mm/a. The age of the sedimentary fill o[approximately] the La Gonzalez pull-apart basin suggests that the 7-9 km right-lateral offset necessary to produce it took place in Middle to Late Pleistocene time. The majority of seismic events are well aligned with the main fault trace; minor events are distributed in a belt several kilometers wide. Focal depth is typically 15 km and focal mechanisms indicate an average east-west compression across the zone. Return periods of 135-460 a (Richter M = 8), 45-70 a (M = 7), and 7-15 a (M = 6) have been calculated. Geodetic studies of several sites along the zone indicate compressive and right-lateral components; at Mucubaji the rate of right-lateral displacement observed is about 1 mm every 5 months (15 a of measurements).

  7. Ozonisation of model compounds as a pretreatment step for the biological wastewater treatment

    International Nuclear Information System (INIS)

    Degen, U.

    1979-11-01

    Biological degradability and toxicity of organic substances are two basic criteria determining their behaviour in natural environment and during the biological treatment of waste waters. In this work oxidation products of model compounds (p-toluenesulfonic acid, benzenesulfonic acid and aniline) generated by ozonation were tested in a two step laboratory plant with activated sludge. The organic oxidation products and the initial compounds were the sole source of carbon for the microbes of the adapted activated sludge. The progress of elimination of the compounds was studied by measuring DOC, COD, UV-spectra of the initial compounds and sulfate. Initial concentrations of the model compounds were 2-4 mmole/1 with 25-75ion of sulfonic acids. As oxidation products of p-toluenesulfonic acid the following compounds were identified and quantitatively measured: methylglyoxal, pyruvic acid, oxalic acid, acetic acid, formic acid and sulfate. With all the various solutions with different concentrations of initial compounds and oxidation products the biological activity in the two step laboratory plant could maintain. p-Toluenesulfonic acid and the oxidation products are biologically degraded. The degradation of p-toluenesulfonic acid is measured by following the increasing of the sulfate concentration after biological treatment. This shows that the elimination of p-toluenesulfonic acid is not an adsorption but a mineralization step. At high p-toluenesulfonic acid concentration and low concentration of oxidation products p-toluenesulfonic acid is eliminated with a high efficiency (4.3 mole/d m 3 = 0.34 kg p-toluenesulfonic acid/d m 3 ). However at high concentration of oxidation products p-toluenesulfonic acid is less degraded. The oxidation products are always degraded with an elimination efficiency of 70%. A high load of biologically degradable oxidation products diminished the elimination efficiency of p-toluenesulfonic acid. (orig.) [de

  8. Efeitos de extratos alcoólicos de plantas sobre o caruncho do feijão vigna (Callosobruchus maculatus Effect of alcoholic extract of plants on weevil of cowpea (Callosobruchus maculatus

    Directory of Open Access Journals (Sweden)

    Francisco de A. C. Almeida

    2005-12-01

    Full Text Available Através de três métodos, extratos vegetais foram aplicados, ao Callosobruchus maculatus na fase adulta, inoculados ou não em uma massa de sementes, e na fase imatura (ovo com o objetivo de se controlar esta praga do feijão armazenado. Utilizaram-se flores, folhas, frutos e caule secos de oito espécies vegetais na obtenção dos extratos, em percolador, com solvente álcool etílico (70%. O delineamento experimental utilizado foi o inteiramente ao acaso, com os tratamentos distribuídos em esquema fatorial, cujos fatores quantitativos foram revelados pela regressão na análise de variância. Mediante os resultados obtidos, concluiu-se que a mortalidade dos insetos está relacionada com o tipo de extrato, os métodos de aplicação e com a dosagem aplicada, sendo os extratos de Callopogonium caeruleum e Piper nigrum os mais eficientes no controle do caruncho de feijão.Vegetable extracts were applied, through three methods, to the Callosobruchus maculatus in the adult phase, inoculated or not in a mass of seeds, in the immature phase (egg with the objective of controlling this pest of the stored beans. Dry flowers, leaves, fruits and dry stems of eight vegetable species were used to obtain the extracts in an extractor, with ethyl alcohol (70%. A completely randomized statistical design was used with the treatments distributed in a factorial scheme, the quantitative factors were analysed by the regression in the variance analysis. From the results obtained, it was concluded that the mortality of the insects is related to the extract type, the application methods and the applied dose, being the extracts of Callopogonium caeruleum and Piper nigrum the most efficient in the control of the weevil of cowpea.

  9. Enhanced virus resistance in transgenic maize expressing a dsRNA-specific endoribonuclease gene from E. coli.

    Directory of Open Access Journals (Sweden)

    Xiuling Cao

    Full Text Available Maize rough dwarf disease (MRDD, caused by several Fijiviruses in the family Reoviridae, is a global disease that is responsible for substantial yield losses in maize. Although some maize germplasm have low levels of polygenic resistance to MRDD, highly resistant cultivated varieties are not available for agronomic field production in China. In this work, we have generated transgenic maize lines that constitutively express rnc70, a mutant E. coli dsRNA-specific endoribonuclease gene. Transgenic lines were propagated and screened under field conditions for 12 generations. During three years of evaluations, two transgenic lines and their progeny were challenged with Rice black-streaked dwarf virus (RBSDV, the causal agent of MRDD in China, and these plants exhibited reduced levels of disease severity. In two normal years of MRDD abundance, both lines were more resistant than non-transgenic plants. Even in the most serious MRDD year, six out of seven progeny from one line were resistant, whereas non-transgenic plants were highly susceptible. Molecular approaches in the T12 generation revealed that the rnc70 transgene was integrated and expressed stably in transgenic lines. Under artificial conditions permitting heavy virus inoculation, the T12 progeny of two highly resistant lines had a reduced incidence of MRDD and accumulation of RBSDV in infected plants. In addition, we confirmed that the RNC70 protein could bind directly to RBSDV dsRNA in vitro. Overall, our data show that RNC70-mediated resistance in transgenic maize can provide efficient protection against dsRNA virus infection.

  10. Determinación de características físicas en semillas de quinua (Chenopodium quinoa Willd. mediante procesamiento digital de imágenes

    Directory of Open Access Journals (Sweden)

    Percy Arapa Carcasi

    2014-12-01

    Full Text Available Las propiedades físicas de las semillas influencian parámetros de trabajo en los equipos y son esenciales para el diseño de estos y de instalaciones para la recolección, cosecha, transporte, separación, secado, aireación, almacenamiento y procesamiento. En la determinación de propiedades físicas algunas dependen o se originan de las dimensiones ortogonales. Los granos o semillas de quinua (Chenopodium quinoa Willd. se caracterizan por su pequeño tamaño. El propósito de este trabajo fue determinar características físicas en semillas de quinua mediante procesamiento digital de imágenes. Se usaron computadoras, cámaras digitales y un escáner. Se utilizaron dos muestras de quinua procesada. Con la primera muestra se ensayaron los programas PHOTO-PAINT, Photoshop, Paint, SmartGrain y GrainScan para comparación. Con Photoshop se determinó el color en porción de granos y de harina. Con la segunda muestra se midieron dimensiones con PHOTO-PAINT, que no ofreció diferencias con Photoshop y Paint, para la determinación de las características físicas. Hubo diferencias estadísticas significativas (p 0,05 entre los programas (PHOTO-PAINT, SmartGrain y GrainScan. Los valores de las coordenadas colorimétricas en la muestra de semillas de quinua fueron L* 70, a* 8 y b* 44 y en la harina L* 71, a* 3 y b* 34. La segunda muestra presentó valores promedios de largo 2,3638; ancho 2,0129 y espesor 1,0605 mm.

  11. Role of heat exchangers in helium liquefaction cycles: Simulation studies using Collins cycle

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, Rijo Jacob, E-mail: rijojthomas@gmail.com [Cryogenic Engineering Centre, Indian Institute of Technology, Kharagpur 721302 (India); Ghosh, Parthasarathi; Chowdhury, Kanchan [Cryogenic Engineering Centre, Indian Institute of Technology, Kharagpur 721302 (India)

    2012-01-15

    Highlights: Black-Right-Pointing-Pointer Role of heat exchangers in basic helium liquefier analyzed to design large-scale ones. Black-Right-Pointing-Pointer Heat exchangers that determine inlet temperature to expanders are more significant. Black-Right-Pointing-Pointer Limiting values of nondimensional UA for each heat exchanger have been determined. Black-Right-Pointing-Pointer Extra area distributed such that effectiveness of all heat exchangers increase uniformly. Black-Right-Pointing-Pointer Heat exchanger performance variation have little influence on the optimum expander flow. - Abstract: Energy efficiency of large-scale helium liquefiers generally employed in fusion reactors and accelerators is determined by the performance of their constituting components. Simulation with Aspen HYSYS{sup Registered-Sign} V7.0, a commercial process simulator, helps to understand the effects of heat exchanger parameters on the performance of a helium liquefier. Effective UA (product of overall heat transfer coefficient U, heat transfer surface area A and deterioration factor F) has been taken as an independent parameter, which takes into account all thermal irreversibilities and configuration effects. Nondimensionalization of parameters makes the results applicable to plants of any capacity. Rate of liquefaction is found to increase linearly with the effectiveness of heat exchangers. Performance of those heat exchangers that determine the inlet temperatures to expanders have more influence on the liquid production. Variation of sizes of heat exchangers does not affect the optimum rate of flow through expanders. Increasing UA improves the rate of liquid production; however, the improvement saturates at limiting UA. Maximum benefit in liquefaction is obtained when the available heat transfer surface area is distributed in such a way that the effectiveness remains equal for all heat exchangers. Conclusions from this study may be utilized in analyzing and designing large helium plants.

  12. Role of heat exchangers in helium liquefaction cycles: Simulation studies using Collins cycle

    International Nuclear Information System (INIS)

    Thomas, Rijo Jacob; Ghosh, Parthasarathi; Chowdhury, Kanchan

    2012-01-01

    Highlights: ► Role of heat exchangers in basic helium liquefier analyzed to design large-scale ones. ► Heat exchangers that determine inlet temperature to expanders are more significant. ► Limiting values of nondimensional UA for each heat exchanger have been determined. ► Extra area distributed such that effectiveness of all heat exchangers increase uniformly. ► Heat exchanger performance variation have little influence on the optimum expander flow. - Abstract: Energy efficiency of large-scale helium liquefiers generally employed in fusion reactors and accelerators is determined by the performance of their constituting components. Simulation with Aspen HYSYS ® V7.0, a commercial process simulator, helps to understand the effects of heat exchanger parameters on the performance of a helium liquefier. Effective UA (product of overall heat transfer coefficient U, heat transfer surface area A and deterioration factor F) has been taken as an independent parameter, which takes into account all thermal irreversibilities and configuration effects. Nondimensionalization of parameters makes the results applicable to plants of any capacity. Rate of liquefaction is found to increase linearly with the effectiveness of heat exchangers. Performance of those heat exchangers that determine the inlet temperatures to expanders have more influence on the liquid production. Variation of sizes of heat exchangers does not affect the optimum rate of flow through expanders. Increasing UA improves the rate of liquid production; however, the improvement saturates at limiting UA. Maximum benefit in liquefaction is obtained when the available heat transfer surface area is distributed in such a way that the effectiveness remains equal for all heat exchangers. Conclusions from this study may be utilized in analyzing and designing large helium plants.

  13. 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer

    Directory of Open Access Journals (Sweden)

    Monica Pires Ribeiro

    2013-01-01

    Full Text Available OBJECTIVE: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of 99mTc-thymine in mammary lesions. METHODS: A total of 45 patients were included in this study. Thirty-three patients (73% were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results. RESULTS: The majority of patients (64.4% had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with 99mTc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively, and an accuracy of 82.2%. CONCLUSIONS: The results of this study are consistent with those previously reported by other authors. The good specificity and high negative predictive value of this technique and the absence of uptake in the heart indicate that it may be a promising complementary method in clinical practice and that it may contribute to reducing unnecessary benign biopsies.

  14. PENGARUH CAMPURAN EKSTRAK AGLAIA HARMSIANA PERKINS DAN DYSOXYLUM ACUTANGULUM MIQ. (MELIACEAE TERHADAP MORTALITAS DAN OVIPOSISI PLUTELLA XYLOSTELLA (L. (LEPIDOPTERA: YPONOMEUTIDAE

    Directory of Open Access Journals (Sweden)

    Lucy Yuswanti

    2014-08-01

    Full Text Available Effect of Mixture of Aglaia harmsiana Perkins and  Dysoxylum acuntangum Miq. (Meliaceae Extracts on Mortality and Oviposition of Plutella xyostella (L. (Lepidoptera: Yponomeutidae. This study was conducted to evaluate the effect of mixture of extracts of Aglaia harmsiana seeds and Dysoxylum acutangulum leaf petioles on mortality and oviposition of Plutella xyostella (L. (Lepidoptera: Yponomeutidae. The insecticidal activity of ethyl acetate fraction of A. harmsiana and D. Acutangulum extracts and their mixture (concentration ratio of Ah and Da was 4:1 was evaluated against the thrid-instar P. xylostella was assessed by choice tests using broccoli seddlings. LC50 and LC95 of A. harmsiana extracts against the thirds the+fourth instar larvae were 0.054% and 0.129%, respectively, those of D. acutangulum extract were 0.031% and 0.103%, and those of the the mixture of A. harmsiana and D.acutangulum extract and the mixture at concentrations of 0.06% - 0.38%, 0.3%, and 0.02% - 0.3%, respectively, significantly reduced the number of eggs deposited by the female, P. xylostella on broccoli seedings, with oviposition inhibition indices of 0.30-0.59, 0.28-0.45 and 0.045-0.70. A.harmsiana ectract at all concentrations tested was phytotoxic to broccoli seedlings, whereas D. acutangulum extract was not. Mixture of A. harmsiana and D. acutangulum extract were phytotoxic to broccoli seedlings at concentrations of 0.06-0.3%. Thus, A. hamarsiana extract of mixture containing the extract should be used with caution and their phytotoxicity should be specifically tested on target crops before being used in the field.

  15. Evaluación de la relación beneficio/riesgo en la terapéutica de pacientes geriátricos

    Directory of Open Access Journals (Sweden)

    Guido E Lluis Ramos

    2002-12-01

    Full Text Available Se realizó un estudio descriptivo de una muestra de 123 pacientes ingresados en el Kurhotel Escambray, Tope de Collantes, por el Programa Geriátrico-Revitalizador durante el período 1998-1999. Los grupos etáreos de mayor porcentaje fueron los comprendidos entre 60 y 65 y 66 y 70 años (26,8 y 23,6 % respectivamente. El sexo femenino fue ligeramente predominante (54,4 % y la raza blanca fue la más frecuente (84 %. La polifarmacia se presentó en el 24,4 % de los casos, las reacciones adversas medicamentosas estuvieron presentes en el 7,4 % de los pacientes, siendo la nifedipina y el ácido acetil salicílico (ASA los fármacos que con mayor frecuencia las ocasionaron. Las interacciones medicamentosas ocuparon el 41 % de la muestra y solo el 2 % fue clasificado, según gravedad, en mayor. La relación beneficio/riesgo se consideró favorable para nuestros pacientes.A descriptive study of 123 patients admitted in Escambray Kurhotel, Topes de Collantes, by the Geriatric Revitalization Program, from 1998 to 1999, was conducted. The age groups 60-65 and 66-70 showed the highest percentages (26.8 and 23.6 %, respectively. A slight predominance of females (54 % was observed. Most of the individuals were white (84 %. Polypharmacy was found in 24.4 % of the cases. Adverse reactions were detected in 7.4 % of the patients. Nifedipine and acetylsalicylic acid (ASA caused these effects more frequently. Drug interactions accounted for 41 % of the sample and only 2 % were considered as major severity. The benefit/risk relationship was favorable for our patients.

  16. Mortalidad prematura por enfermedades infecciosas en España, 1908-1995

    Directory of Open Access Journals (Sweden)

    Mirón Canelo José Antonio

    2002-01-01

    Full Text Available Objetivos. Las enfermedades infecciosas han sido tradicionalmente una de las principales causas de muerte en los países desarrollados. Los objetivos del presente trabajo consistieron en cuantificar la importancia de las enfermedades infecciosas como causa de muerte prematura en España entre 1908 y 1995, y conocer la frecuencia y distribución de las enfermedades infecciosas con mayor impacto sobre la mortalidad prematura. Métodos. El estudio se realizó a partir de los datos de mortalidad por causas infecciosas publicados por el Instituto Nacional de Estadística en el Movimiento Natural de la Población para el período en estudio. Se utilizan como indicadores de mortalidad prematura los años de vida potencial perdidos (AVPP, la tasa bruta de AVPP por 1 000 habitantes y el porcentaje y la media de AVPP. Resultados. Entre 1908 y 1995, el número y la tasa de AVPP por causas infecciosas experimentaron una evolución claramente descendente. El descenso fue más acusado a partir de los años 50 y se observó en todos los grupos de edad. La tuberculosis fue la primera causa de muerte prematura desde principios de siglo hasta los años 70. A partir de esta fecha toman el relevo las neumonías y el sida. Conclusiones. El impacto de las enfermedades infecciosas como determinantes de muerte prematura en España ha descendido a lo largo del siglo XX, sobre todo a partir de los años 70.

  17. Improving Pediatric Cancer Care Disparities Across the United States–Mexico Border: Lessons Learned from a Transcultural Partnership between San Diego and Tijuana

    Science.gov (United States)

    Aristizabal, Paula; Fuller, Spencer; Rivera, Rebeca; Beyda, David; Ribeiro, Raul C.; Roberts, William

    2015-01-01

    In 2007, the 5-year survival rate for children with acute leukemia in Baja California, Mexico was estimated at 10% (vs. 88% in the United States). In response, stakeholders at St. Jude Children’s Research Hospital, Rady Children’s Hospital San Diego, and the Hospital General de Tijuana (HGT) implemented a transcultural partnership to establish a pediatric oncology program. The aim was to improve clinical outcomes and overall survival for children in Baja California. An initial needs assessment evaluation was performed and a culturally sensitive, comprehensive, 5-year plan was designed and implemented. After six years, healthcare system accomplishments include the establishment of a fully functional pediatric oncology unit with 60 new healthcare providers (vs. five in 2007). Patient outcome improvements include a rise in 5-year survival for leukemia from 10 to 43%, a rise in new cases diagnosed per year from 21 to 70, a reduction in the treatment abandonment rate from 10% to 2%, and a 45% decrease in the infection rate. More than 600 patients have benefited from this program. Knowledge sharing has taken place between teams at the HGT and Rady Children’s Hospital San Diego. Further, one of the most significant outcomes is that the HGT has transitioned into a regional referral center and now mentors other hospitals in Mexico. Our results show that collaborative initiatives that implement long-term partnerships along the United States–Mexico border can effectively build local capacity and reduce the survival gap between children with cancer in the two nations. Long-term collaborative partnerships should be encouraged across other disciplines in medicine to further reduce health disparities across the United States–Mexico border. PMID:26157788

  18. Improving Pediatric Cancer Care Disparities Across the United States-Mexico Border: Lessons Learned from a Transcultural Partnership between San Diego and Tijuana.

    Science.gov (United States)

    Aristizabal, Paula; Fuller, Spencer; Rivera, Rebeca; Beyda, David; Ribeiro, Raul C; Roberts, William

    2015-01-01

    In 2007, the 5-year survival rate for children with acute leukemia in Baja California, Mexico was estimated at 10% (vs. 88% in the United States). In response, stakeholders at St. Jude Children's Research Hospital, Rady Children's Hospital San Diego, and the Hospital General de Tijuana (HGT) implemented a transcultural partnership to establish a pediatric oncology program. The aim was to improve clinical outcomes and overall survival for children in Baja California. An initial needs assessment evaluation was performed and a culturally sensitive, comprehensive, 5-year plan was designed and implemented. After six years, healthcare system accomplishments include the establishment of a fully functional pediatric oncology unit with 60 new healthcare providers (vs. five in 2007). Patient outcome improvements include a rise in 5-year survival for leukemia from 10 to 43%, a rise in new cases diagnosed per year from 21 to 70, a reduction in the treatment abandonment rate from 10% to 2%, and a 45% decrease in the infection rate. More than 600 patients have benefited from this program. Knowledge sharing has taken place between teams at the HGT and Rady Children's Hospital San Diego. Further, one of the most significant outcomes is that the HGT has transitioned into a regional referral center and now mentors other hospitals in Mexico. Our results show that collaborative initiatives that implement long-term partnerships along the United States-Mexico border can effectively build local capacity and reduce the survival gap between children with cancer in the two nations. Long-term collaborative partnerships should be encouraged across other disciplines in medicine to further reduce health disparities across the United States-Mexico border.

  19. Atividades antiúlcera e antioxidante Baccharis trimera (Less DC (Asteraceae

    Directory of Open Access Journals (Sweden)

    Larissa Funabashi de Toledo Dias

    Full Text Available A "carqueja", Baccharis trimera (Less DC (Asteraceae, é uma espécie vegetal característica de regiões tropicais, muito utilizada na medicina popular como antiinflamatória, hipoglicemiante e em tratamento de problemas digestivos. A avaliação da atividade antiúlcera do extrato bruto liofilizado e do extrato liofilizado da "resina" (porção que durante a concentração dos extratos ficava depositada no fundo do recipiente com aspecto viscoso e pegajoso foi realizada através de indução aguda por etanol acidificado. O extrato bruto liofilizado, na dose de 400 mg/ kg, reduziu a área de lesão em 90%, 200 mg/kg, 87%, 100 mg/kg, 66% e o fármaco controle (lansoprazol, 66%. O extrato liofilizado da "resina", administrado na dose de 400 mg/kg, reduziu a área de lesão em 82%, 200 mg/kg, 82%, 100 mg/kg, 53% e o fármaco controle (lansoprazol, 70%. A atividade antioxidante foi ensaiada com extrato bruto liofilizado, extrato liofilizado da "resina", pó da droga e frações clorofórmica, acetato de etila, etanol e etanol 50% através do método que reduz o radical 2,2'-difenil-1-picril-hidrazil (DPPH, permitindo após o equilíbrio da reação, calcular a quantidade de antioxidante gasta para reduzir 50% do DPPH, apresentando resultado evidente, comparado à vitamina E. Não foram verificados sinais de alteração aparente no ensaio de toxicidade na dose única de 5g/kg, em camundongos.

  20. [Test and programme sensitivities of screening for colorectal cancer in Reggio Emilia].

    Science.gov (United States)

    Campari, Cinzia; Sassatelli, Romano; Paterlini, Luisa; Camellini, Lorenzo; Menozzi, Patrizia; Cattani, Antonella

    2011-01-01

    to estimate the sensitivity of the immunochemical test for faecal occult blood (FOBT) and the sensitivity of the colorectal tumour screening programme in the province of Reggio Emilia. retrospective cohort study, including a sample of 80,357 people of both genders, aged 50-69, who underwent FOBT, during the first round of the screening programme in the province of Reggio Emilia, from April 2005 to December 2007. incidence of interval cancer. The proportional incidence method was used to estimate the sensitivity of FOBT and of the screening programme. Data were stratified according to gender, age and year of interval. the overall sensitivity of FOBT was 73.2% (95%IC 63.8-80.7). The sensitivity of FOBT was lower in females (70.5% vs 75.1%), higher in the 50-59 age group (78.6% vs 70.2%) and higher in the colon than rectum (75.1% vs 68.9%). The test had a significantly higher sensitivity in the 1st year of interval than in the 2nd (84.4% vs 60.5%; RR=0.39, 95%IC 0.22-0.70), a difference which was confirmed, also when data were stratified according to gender. The overall sensitivity of the programme is 70.9% (95%IC 61.5-78.5). No statistically significant differences were shown, if data were stratified according to gender, age or site. Again the sensitivity in the 1st year was significantly higher than in the 2nd year of interval (83.2% vs 57.0%; RR=0.41, 95%IC 0.24-0.69). Overall our data confirmed the findings of similar Italian studies, despite subgroup analysis showed some differences in sensitivity in our study.

  1. Lost in interpretation: should the highest VC value be used to calculate the FEV1/VC ratio?

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    Fortis S

    2016-09-01

    Full Text Available Spyridon FortisDepartment of Medicine, Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa, Iowa City, IA, USAAirflow obstruction or obstructive ventilatory defect (OVD is defined as low forced expiratory volume in 1 second (FEV1 to vital capacity (VC ratio. VC can be measured in various ways, and the definition of “low FEV1/VC” ratio varies.     VC can be measured during forced expiration before bronchodilators (forced vital capacity [FVC] and after bronchodilators (post-FVC, and during slow expiration (slow vital capacity [SVC] and during inspiration (inspiratory vital capacity [IVC]. Theoretically, in a healthy person, VC values should be the same regardless of the maneuver used. Nevertheless, SVC is usually larger than FVC except in patients with no OVD and body mass index <25 kg/m2.1 In obstructive lung diseases, FVC may be reduced, which may result in an increase of FEV1/FVC ratio and misdiagnosis.2 For that reason, American Thoracic Society–European Respiratory Society recommends using SVC or IVC to calculate the FEV1/VC ratio.2 Approximately, 10% of smokers have FEV1% predicted <80% and FEV1/FVC >70%, a pattern known as preserved ratio impaired spirometry.3 Of all the subjects with FVC below the lower limit of normal (LLN and FEV1/FVC > LLN, only 64% have restriction in lung volumes. The rest 36% have a nonspecific Pulmonary Function Test pattern.4 Approximately, 15% of patients with this nonspecific PFT pattern develop OVD in follow-up PFTs.4 It is possible that a portion of patients with obstructive lung disease remain underdiagnosed when FVC is used to compute FEV1/FVC ratio.View the original paper by Torén and colleagues.

  2. Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer’s Disease

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    Ximeng Yang

    2018-01-01

    Full Text Available Alzheimer’s disease (AD is a progressive neurodegenerative disorder resulting in structural brain changes and memory impairment. We hypothesized that reconstructing neural networks is essential for memory recovery in AD. Heat shock cognate 70 (HSC70, a member of the heat shock protein family of molecular chaperones, is upregulated in AD patient brains, and recent studies have demonstrated that HSC70 facilitates axonal degeneration and pathological progression in AD. However, the direct effects of HSC70 inhibition on axonal development and memory function have never been investigated. In this study, we examined the effects of a small-molecule HSC70 inhibitor, VER-155008, on axonal morphology and memory function in a mouse model of AD (5XFAD mice. We found that VER-155008 significantly promoted axonal regrowth in amyloid β-treated neurons in vitro and improved object recognition, location, and episodic-like memory in 5XFAD mice. Furthermore, VER-155008 penetrated into the brain after intraperitoneal administration, suggesting that VER-155008 acts in the brain in situ. Immunohistochemistry revealed that VER-155008 reduced bulb-like axonal swelling in the amyloid plaques in the perirhinal cortex and CA1 in 5XFAD mice, indicating that VER-155008 also reverses axonal degeneration in vivo. Moreover, the two main pathological features of AD, amyloid plaques and paired helical filament tau accumulation, were reduced by VER-155008 administration in 5XFAD mice. This is the first report to show that the inhibition of HSC70 function may be critical for axonal regeneration and AD-like symptom reversal. Our study provides evidence that HSC70 can be used as a new therapeutic target for AD treatment.

  3. Valoración de plantas curativas comercializadas en los mercados locales de los municipios de El Cerrito y Palmira, Valle del Cauca, Colombia

    Directory of Open Access Journals (Sweden)

    Richard Danilo Peña Cuellar

    2014-12-01

    Full Text Available Muchas especies vegetales, además del uso alimenticio, poseen utilidades medicinales, aromáticas, ornamentales, condimentarias y mágicas. Esta investigación tuvo como objetivo inventariar y valorar la flora medicinal comercializada en los mercados de los municipios de Palmira y El Cerrito (Valle del Cauca, Colombia y así conocer sus usos en estas comunidades. Metodológicamente, se hizo el registro de 180 morfo-especies, de las cuales se identificaron 109 hasta la categoría de especie, distribuidas en 45 familias taxonómicas. Se encontró que en ambas localidades la parte más empleada de la planta son las hojas (45 y 47%, respectivamente y el tallo (19 y 24%, respectivamente. El uso principal de estas plantas es medicinal (>45% y mágico (>10%. Éstas son utilizadas principalmente mediante infusión (49 y 53%, respectivamente. La presentación física más habitual es en fresco, 30% para Palmira, y para El Cerrito, 70%. A pesar de la cercanía geográfica, las plantas que llegan a los mercados de las localidades difieren en estatus (local o introducida, silvestre o cultivada y en atributos como el sabor y el efecto. Las especies usadas para El Cerrito son principalmente locales (70%. Se estableció el inventario de las plantas medicinales, aromáticas y condimentarias (PMACs comercializadas en la región y se determinaron sus relaciones entre localidades, el valor de uso, el beneficio y el potencial en estas comunidades. Se concluye que la cultura local (saber ancestral y la diferencia intergeneracional sobre algunas variables son determinantes para el uso, el manejo y la conservación de las especies útiles.

  4. [Deficient identification of signs and symptoms in Streptoccoci amigdalitis].

    Science.gov (United States)

    Carranza-Martínez, Martha Imelda; Valdés-Croda, Oscar; Jaspersen-Gastelum, Víctor; Chavolla-Magaña, Rogelio; Villaseñor-Sierra, Alberto

    2006-01-01

    To evaluate the degree of identification of main signs and symptoms of streptococcal pharyngitis by resident doctors, general practitioners, family physicians and pediatricians. A prospective, cross-sectional and comparative study was done. A validated questionnaire was applied including the following topics: social demographic, main signs and symptoms, clinical cases; and clinical pictures. We interviewed resident doctors (n = 40), general physicians (n = 21), family physicians (n = 35) and pediatricians (n = 19) from different institutions (SSa, ISSSTE, IMSS) in Guadalajara, Mexico, from March to August 2005. Scores were interpreted as very good, good, regular and poor, and these scores were related with the specialty and clinical years of experience. chi2, student t test and linear regression. This study included 115 physicians between 22 to 60 years old (mean = 39) and with 0 to 31 (mean = 10) clinical years of experience. Regarding the conceptual identification of main signs and symptoms, tonsil exudates were recognized by 33 to 61% of physicians, and a clinical case of streptococcal tonsillitis was recognized by 50 to 70%. A clinical picture of tonsil caseum was misinterpreted as streptococcal tonsillitis by 13 to 35% of the physicians. There was no association between years of clinical experience and the scores obtained in clinical cases (r = 0.20) or clinical pictures (r = 0.09). The clinical identification of streptococcal tonsillitis was regular to poor among all the interviewed physicians, and there had no correlation with the years of clinical experience. The reinforcement in teaching to recognize the key signs and symptoms of streptococcal tonsillitis at medical school would result in better recognition, more rational use of antimicrobials and reduction in health institutions costs.

  5. Propuesta de ejercicios para la enseñanza de la formación básica (natación en las personas de la tercera edad de la escuela comunitaria “Pedro Téllez Váldes” del municipio Pinar del Río

    Directory of Open Access Journals (Sweden)

    Mario Blanco Puentes

    2007-09-01

    Full Text Available El envejecimiento se asocia a una reducción de la capacidad aeróbica máxima y de la fuerza muscular, así como de la capacidad funcional en general, así podemos cOMSiderar que el ser humano evoluciona físicamente hasta los 20 años e involuciona claramente entre los 65-70 años. En el año 2000 se elevó los años de la población mundial a un promedio de 65 años. Según estudios realizados por la Organización de Naciones Unidas para la Salud (OMS para el 2025, uno de cada cinco personas estará en la tercera edad. En siglo XX las perspectivas de vida a nivel mundial eran de apenas 50 años de edad, para el 2050 el número de personas de la tercera edad aumentará de 600 millones a 2 billones, en menos de 50 años habrá por primera vez mas personas con 60 años que jóvenes con 15 años, según dicho organismo en los países en vía de desarrollo se cuadriplicara la población de las personas de la tercera edad, para la mitad de este siglo, estima la OMS más de 2 millones tendrá 100 años o más.

  6. Estereotipos negativos hacia la vejez en personas mayores de Latinoamérica

    Directory of Open Access Journals (Sweden)

    Viviana X. Lasagni Colombo

    2014-03-01

    Full Text Available Introducción: Los objetivos del estudio se centran en investigar la presencia de estereotipos hacia la vejez en adultos mayores de diez países de Latinoamérica. Comparar el nivel de estereotipos entre países y evaluar la influencia de variables socio-demográficas en la formación de estereotipos. Metodología: Se realizó un estudio descriptivo transversal en adultos mayores de 60 a 70 años (N: 965 residentes en diez países de Latinoamérica. Se aplicó el Cuestionario de Estereotipos Negativos hacia la Vejez (CENVE y se estudió las posibles asociaciones entre variables socio demográficas y los factores del CENVE a través del análisis de varianzas (ANOVA. Los resultados demuestran que existen estereotipos negativos hacia la vejez en las personas mayores siendo más baja la presencia de estos en el factor motivacional. Se comprobó la relación significativa con variables “ocupación” y “nivel de escolaridad” y se corroboró la diferencia en la presencia de estereotipos negativos hacia la vejez entre los países que conforman este estudio. Conclusión: existen estereotipos negativos hacia la vejez en las personas mayores con diferencias entre grupos de países fundamentalmente por las condiciones sociosanitarias, educativas y económicas por las que atraviesan. El nivel de escolaridad y la situación socioeconómica influyen en la construcción de estereotipos negativos hacia la vejez.

  7. Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities.

    Science.gov (United States)

    Faith, A; Akdis, C A; Akdis, M; Simon, H U; Blaser, K

    1997-07-01

    Development of IgE-mediated allergic conditions is dependent on the secretion of a Th2 cytokine pattern, including IL-4, IL-5, and IL-13. The induction of anergy would be one mechanism to abrogate cytokine secretion by Th2 cells, which may be pivotal to the allergic response. We demonstrate here that incubation of cloned human CD4+ phospholipase A2 (PLA)-specific Th2 cells with antigenic peptide, in the absence of professional APC, results in a state of nonresponsiveness. The anergic T cells failed to proliferate or secrete IL-4 in response to optimal stimulation with PLA and autologous, professional APC. Secretion of IL-5 and IL-13, however, was only partially inhibited. The anergic state of the Th2 cells was not associated with CD3 or CD28 down-regulation. However, anergy did appear to be closely related to alterations in signaling pathways, mediated through the TCR, of the cells. In contrast to untreated Th2 cells, anergized Th2 cells failed to respond to anti-CD3 mAb with either increased tyrosine kinase activity or increased levels of tyrosine phosphorylation of p56(lck) or ZAP70. A strong and sustained intracellular calcium flux, observed in untreated Th2 cells in response to anti-CD3 mAb, was absent in anergic Th2 cells. Furthermore, the induction of anergy seems to represent an active process, associated with increased levels of basal tyrosine kinase activity, cytokine production, and CD25 up-regulation in anergic Th2 cells. Together, our results indicate that anergy in Th2 cells is associated with defective transmembrane signaling through the TCR.

  8. Comparative Analysis of Welded and Adhesive Joints Strength Made of Acid-Resistant Stainless Steel Sheets

    Directory of Open Access Journals (Sweden)

    Izabela Miturska

    2017-12-01

    Full Text Available The article presents the selected results of strength tests on the effectiveness of bonding high-alloy steel 1.4310. Sheet steel is one of the materials that are difficult to activate energy. Effective joining of it is difficult, requires selection of the appropriate bonding technology. The paper focuses on the comparative tests the shear strength of one-single lap welded and bonded joints. The welding process was performed 3 groups of samples TIG welding and argon, where the variable value of the welding process was current: 60A, 70A, 80A. The adhesion process was performed in 6 groups of samples which differed in the method of surface preparation and the type of the adhesive. Adhesive joints were made by using adhesive of epoxy resin and a hardener: Epidian 61/TFF at a mass ratio of 100:22 and Epidian 61/IDA at a mass ratio of 100:40. As a way of surface preparation applied 3 different, but simplified and environmentally friendly methods of surface preparation: degreasing with using cleaner Loctite 7061, abrasive machining with P320 and degreasing and grinding with abrasive T800 and degreasing were used. Make joints and curing the adhesive joints were carried out at ambient temperature. Analyzed the joints were tested destructive - which set out the shear strength, in accordance with DIN EN 1465 on the testing machine Zwick / Roell Z150. Based on the results of research it was found that better results were obtained for the maximum welded joints, but this result was similar to the maximum value of the strength of the adhesive bond.

  9. Hsc70 facilitates TGF-β-induced activation of Smad2/3 in fibroblastic NRK-49F cells

    Energy Technology Data Exchange (ETDEWEB)

    Ikezaki, Midori; Higashimoto, Natsuki; Matsumura, Ko; Ihara, Yoshito, E-mail: y-ihara@wakayama-med.ac.jp

    2016-08-26

    Heat-shock cognate protein 70 (Hsc70), a molecular chaperone constitutively expressed in the cell, is involved in the regulation of several cellular signaling pathways. In this study, we found that TGF-β-induced phosphorylation and nuclear translocation of Smad2/3 were suppressed in fibroblastic NRK-49F cells treated with small interfering RNA (siRNA) for Hsc70. In the cells underexpressing Hsc70, transcriptional induction of connective tissue growth factor (CTGF), a target gene of the TGF-β signaling, was also suppressed in the early phase of TGF-β stimulation. Upon stimulation with TGF-β, Hsc70 interacted with Smad2/3, suggesting functional interactions of Hsc70 and Smad2/3 for the activation of TGF-β-induced Smad signaling. Although the expression of heat-shock protein 70 (Hsp70) was upregulated in the cells treated with Hsc70 siRNA, TGF-β-induced Smad activation was not affected in the cells overexpressing Hsp70. Collectively, these results indicate that Hsc70, but not Hsp70, supportively regulates TGF-β-induced Smad signaling in NRK-49F cells. - Highlights: • Hsc70 siRNA treatment suppressed the expression of Hsc70 but induced the expression of Hsp70 in NRK-49F cells. • Hsc70 siRNA treatment suppressed the activation of Smad2/3 in the cells treated with TGF-β. • Hsc70 interacted with Smad2/3 on stimulation with TGF-β in the cells. • Hsp70 did not influence the TGF-β-induced activation of Smad2/3 in the cells overexpressing Hsp70.

  10. Biosynthesis and thermal properties of PHBV produced from levulinic acid by Ralstonia eutropha.

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    Yuanpeng Wang

    Full Text Available Levulinic acid (LA can be cost-effectively produced from a vast array of renewable carbohydrate-containing biomaterials. LA could facilitate the commercialization of the polymer poly(hydroxybutyrate-co-hydroxyvalerate (PHBV and PHBV-based products as carbon substrates. Therefore, this paper focused on the production of PHBV by Ralstonia eutropha with LA for hydroxyvalerate (HV production, which plays an important role in enhancing the thermal properties of PHBV. Accordingly, the HV content of PHBV varied from 0-40.9% at different concentrations of LA. Stimulation of cell growth and PHBV accumulation were observed when 2-6 g L(-1 LA was supplied to the culture. The optimal nitrogen sources were determined to be 0.5 g L(-1 ammonium chloride and 2 g L(-1 casein peptone. It was determined that the optimal pH for cell growth and PHBV accumulation was 7.0. When the cultivation was performed in large scale (2 L fermenter with a low DO concentration of 30% and a pH of 7.0, a high maximum dry cell weight of 15.53 g L(-1 with a PHBV concentration of 12.61 g L(-1 (53.9% HV, up to 81.2% of the dry cell weight, was obtained. The melting point of PHBV found to be decreased as the fraction of HV present in the polymer increased, which resulted in an improvement in the ductility and flexibility of the polymer. The results of this study will improve the understanding of the PHBV accumulation and production by R. eutropha and will be valuable for the industrial production of biosynthesized polymers.

  11. Mortalidade por doenças cardiorrespiratórias em idosos no estado de Mato Grosso, 1986 a 2006

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    Cleber Nascimento do Carmo

    2010-12-01

    Full Text Available OBJETIVO: Descrever a evolução temporal da mortalidade por doenças cardiorrespiratórias em idosos. MÉTODOS: Estudo epidemiológico descritivo com delineamento ecológico de séries temporais realizado no estado do Mato Grosso, de 1986 a 2006. Foram utilizados dados sobre doenças dos aparelhos respiratório e circulatório obtidos do Sistema de Informação sobre Mortalidade do Ministério da Saúde. Modelos de regressão linear simples foram ajustados para avaliar a tendência das taxas específicas de mortalidade por grupos específicos de idade (60 a 69, 70 a 79 e 80 ou mais anos e sexo. RESULTADOS: Houve aumento na proporção de óbitos por doenças respiratórias e diminuição por doenças cardiovasculares. Na comparação de taxas entre os sexos, as mulheres apresentaram taxas 15% menores para as causas cardiovasculares e taxas similares ao sexo masculino para as causas respiratórias. Foi observada taxa elevada de mortalidade por doenças respiratórias e cardiovasculares, com importante tendência de incremento entre os grupos mais longevos. Em idosos com idade > 80 anos o aumento anual médio na taxa de mortalidade por doenças respiratórias foi de 1,99 óbitos e de 3,43 por doenças do aparelho circulatório. CONCLUSÕES: O estado de Mato Grosso apresenta elevada taxa de mortalidade por doenças respiratórias e cardiovasculares em idosos, com importante tendência de incremento entre os grupos mais longevos.

  12. [Observing the density increase curve after intravenous contrast medium administration using a bolus triggering system: a method for detection cardiovascular disorders?].

    Science.gov (United States)

    Stückle, C A; Kickuth, R; Kirchner, E M; Liermann, D; Kirchner, J

    2002-06-01

    Recently bolus tracking systems were developed to improve the timing of intravenous contrast media application in helical computed tomography. We investigated the benefit of this new method as a parameter of the cardiac function. Retrospective analysis of 64 patients which incidentally underwent bolus triggered contrast enhanced helical CT and invasive investigation of the heart within one week. All examinations were performed on the CT scanner Somatom Plus 4 Volume Zoom (Siemens Corp., Forchheim, Germany) using the C.A.R.E. Bolus software. This performs repetitive low-dose test scans (e.g. for the abdomen: 140 kV, 20 mA, Tl 0.5 s) and measures the Hounsfield attenuation (increase over the baseline) in a preselected region of interest. The displayed increase of vascular density over the time after peripheral contrast media injection (75 ml lopromid (300 mg/ml), 2 ml/s) was categorised to three types: (a) rapid increase, (b) deceleration before a 100 HE threshold was reached and (c) one or more peaks. The findings of the invasive investigation of the heart were correlated to the findings of the bolus-tracking measurements. The examinations were categorized as follows: 19 type A, 34 type B, 11 type C. We found a high significant correlation between the type of the Hounsfield attenuation and systolic pressure in the left ventricle. There was no correlation between the type of the Hounsfield attenuation and the diastolic pressure in the left ventricle, the pressures related to the right ventricle or the ejection fraction. The bolus-tacking system showed a sensitivity of 53, a specificity of 82, an accuracy of 70%, a positive predictive value of 70% and a negative predictive value of 70% in detection of left heart failure. The bolus tracking system C.A.R.E.-bolus often shows atypical Hounsfield attenuation in cases of cardiac failure but is not suitable as a screening method of the cardiopulmonary function.

  13. Influencia de los movimientos sacádicos en el rendimiento académico de estudiantes de básica primaria en situación de vulnerabilidad en la ciudad de Cúcuta

    Directory of Open Access Journals (Sweden)

    Gerson Adriano Rincón Álvarez

    2017-06-01

    Full Text Available Objetivo: Determinar si los movimientos sacádicos influyen en el rendimiento académico de estudiantes de básica primaria. Metodología: Se tomó una muestra no probabilística por conveniencia de 121 estudiantes de básica primaria con situación de vulnerabilidad en una Institución Educativa de la ciudad de Cúcuta, Colombia. La muestra se dividió en dos grupos: el primero, de alto rendimiento académico, conformado por 56 estudiantes, 60 % niñas y 40 % niños, con una media de 11,70 años; el segundo, de bajo rendimiento, constituido por 65 estudiantes, 40 % niñas y 60 % niños, con una media de 12,29 años. A ambos grupos se aplicó el test de King y Devick (1976 o test K-D de movimientos sacádicos. Resultados: Los resultados mostraron diferencias estadísticamente significativas entre las medias de los tiempos de lectura de cada una de las tarjetas como en la media del tiempo total de lectura de las tres tarjetas del test K-D. También se encontraron diferencias significativas en el porcentaje de estudiantes que presentan problemas en relación con los movimientos sacádicos: en el grupo con alto rendimiento el porcentaje de estudiantes con problemas relacionados con movimientos oculares en función del tiempo es mucho menor que en el grupo con bajo rendimiento académico. Conclusión: Los resultados ponen de manifiesto la importancia de trabajar los movimient

  14. Irradiated fetal thymus transplantation in a patient with combined immunodeficiency with predominant T cell defect

    International Nuclear Information System (INIS)

    Higuchi, Shigenori; Yanabe, Yasuhide; Tsuchiya, Hiroyuki; Akahoshi, Izumi; Migita, Masahiro; Matsuda, Ichiro; Udaka, Keiji.

    1993-01-01

    A 6 month old boy was diagnosed as a case of combined immunodeficiency (with predominant T cell defect by previous classification). His T cell count was decreased, his B cell count in peripheral blood was increased, his serum IgG level was decreased, his serum IgM level was normal and the thymus was not evident on CT scans and magnetic resonance imaging. Administration of the thymus hormone, thymosin, led to a partial recovery of T cell function without normalization of the T cell count. At age 26 months the patient received an irradiated thymus transplantation from a 16 week old female fetus. After the transplantation, the T cell count (mainly CD4 + cells) increased by 50-70%. A mild graft-versus-host reaction (GVHR) occurred and several immunosuppressants were prescribed. Chromosome analysis showed that the T cells have both 46 XY and 46 XX karyotypes while the B cells have the 46 XY karyotype alone. His cellular immunity (skin tests, DNA synthesis, mixed lymphocyte reaction, cytotoxic activity and natural killer cell function) and his serum IgG level remained low. However, being on regular γ-globulin therapy and oral anti-fungal drugs, he is now living normally with almost no trouble at age 6 years and 3 months. This case showed that irradiated thymus transplantation might be a useful method when an adequate donor for bone marrow transplantation is not available. The unexpected observation that the increased T cells were mainly CD4 may be related to the mild GVHR and the clinical improvement. (author)

  15. Efectividad de la auriculoterapia en el tratamiento de la ansiedad en el adulto mayor

    Directory of Open Access Journals (Sweden)

    María Onelia Díaz Rivadeneira

    2015-05-01

    Full Text Available Se realizó un estudio experimental, para determinar la efectividad de la auriculoterapia en pacientes adultos mayores con ansiedad, comparada con el tratamiento convencional, remitidos a la consulta de Medicina Tradicional y Natural del policlínico “Julio Antonio Mella”, Camagüey, Cuba; en el período comprendido entre enero y diciembre de 2013, previa valoración por psiquiatría. El universo fue de 520 pacientes adultos mayores con diagnóstico de ansiedad generalizada, remitidos de la consulta de psiquiatría de la entidad antes mencionada. La muestra quedó constituida por 60 de ellos, que además no habían ingerido psicofármacos en un período menor a seis semanas. Se formaron dos grupos, uno control (30, con tratamiento convencional, y otro de estudio (30, con auriculoterapia. La asignación de los sujetos a cada grupo fue por el método aleatorio simple. Al grupo de estudio se le aplicó esquema de tratamiento con auriculoterapia y al grupo control se le aplicó tratamiento farmacológico convencional. En los resultados obtenidos se observó que el grupo de edades más afectadas por la ansiedad fue el de 70 a 74 años y predominó el sexo femenino. El insomnio, la irritabilidad y la dificultad de memoria fueron los síntomas que más se observaron en el estudio. Al finalizar el tratamiento los síntomas disminuyeron de forma más apreciable en el grupo tratado con auriculoterapia. La auriculoterapia fue más eficaz en el tratamiento de la ansiedad y es una técnica prácticamente inocua, con la cual se puede disminuir la utilización de psicofármacos

  16. Presencia y severidad de calcio coronario: su relación con la aparición de eventos coronarios agudos

    Directory of Open Access Journals (Sweden)

    Lázaro E. de la Cruz Avilés

    2012-03-01

    Full Text Available Fundamento: la detección de calcio en las arterias coronarias confirma la presencia de aterosclerosis y ha demostrado ser una herramienta útil para estratificar el riesgo cardiovascular. Objetivo: determinar la relación entre la presencia y severidad de calcio coronario con la aparición de eventos coronarios agudos. Métodos: se realizó un estudio observacional, descriptivo, prospectivo, tipo serie de casos, en el Hospital Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos, entre enero y diciembre de 2008. La serie estuvo conformada por 137 pacientes, en los que se estudió: sexo, antecedentes patológicos personales, cifras de glucemia en ayunas, creatinina, colesterol total y triglicéridos. Los pacientes fueron seguidos durante dos años para evaluar la aparición de eventos coronarios agudos. Resultados: La edad media fue de 53,2±7,4 años, con predominio del sexo masculino (52,5 %. El mayor porciento de pacientes clasificados como de alto riesgo, según la cuantificación del calcio coronario (16,8 % perteneció al sexo masculino, predominando en los mayores de 70 años. La diabetes se relacionó de forma significativa con la severidad del puntaje de calcio. El infarto agudo del miocardio fue más frecuente en pacientes con puntaje de calcio mayor de 400 unidades Agatston. Conclusiones: la aparición de eventos coronarios agudos fue más frecuente en los pacientes de alto riesgo según cuantificación del calcio coronario.

  17. Avaliação de critérios para calagem de arroz inundado em casa de vegetação

    Directory of Open Access Journals (Sweden)

    M. Borges Júnior

    1998-06-01

    Full Text Available O presente trabalho foi desenvolvido, no período de maio a setembro de 1995, com o objetivo de avaliar critérios para a recomendação de calcário para o arroz em solos inundados de Minas Gerais. Foram avaliados os efeitos de doses crescentes de carbonatos de cálcio e de magnésio sobre a produção de matéria seca de plantas de arroz em casa de vegetação. O experimento constou de um fatorial completo com dez solos de várzeas e cinco níveis de calagem. Verificou-se que a acidez potencial (H + Al a pH 7,0, a saturação por bases (V, o teor de carbono orgânico (C e o teor de cálcio mais magnésio (Ca + Mg foram as características dos solos que mais influenciaram as doses recomendáveis de calcário. Por outro lado, os teores de Fe e de Mn redutíveis do solo não tiveram influência significativa na recomendação de calagem. O método que visa elevar V a 40% foi mais eficiente na definição das doses recomendáveis para obtenção da matéria seca equivalente a 90% da máxima eficiência física.

  18. Elasticidade-preço da demanda por etanol no Brasil: como renda e preços relativos explicam diferenças entre estados

    Directory of Open Access Journals (Sweden)

    Veronica Fernandez Orellano

    2013-12-01

    Full Text Available Este artigo estuda a demanda por etanol no Brasil no período 2001-2009, considerando as características regionais de renda e de preços relativos. Essas características explicam variação relevante na elasticidade-preço da demanda, aspecto até então desconsiderado em estudos anteriores. Foi estimado um modelo econométrico a partir de um painel de dados estaduais mensais, no qual variáveis instrumentais foram usadas para controlar a endogeneidade na análise da demanda. Conclui-se que a demanda é mais elástica em estados mais pobres e em que o preço relativo está próximo a 70%, a taxa técnica de substituição entre etanol e gasolina, parâmetro relevante para as decisões de consumo de proprietários de veículos flex-fuel. Essas regiões apresentam maiores elasticidades-preço da demanda, em última análise, por conta de diferenças logísticas e tributárias, as quais definem o preço relativo. Esses resultados diferem daqueles obtidos por Salvo e Huse (2013, pois identificam diferenças regionais que independem da heterogeneidade das preferências dos consumidores, mas decorrem da configuração logística e de renda. Os resultados sugerem implicações para as políticas tributária e de infraestrutura logística, as quais, ao afetarem o nível de preços relativos de etanol e gasolina, afetam a sensibilidade da demanda com relação às variações de preço.

  19. ESTIMACIÓN DE LA PREVALENCIA DE HIPOTIROIDISMO SEGÚN DIFERENTES MÉTODOS: DOSIS DIARIA DEFINIDA, DOSIS DIARIA PRESCRITAY REGISTRO DE PACIENTES EN TRATAMIENTO

    Directory of Open Access Journals (Sweden)

    José Escribano-Serrano

    2014-01-01

    Full Text Available Fundamentos: El hipotiroidismo (HT es una patología frecuente en la práctica clínica diaria. No existen datos recientes sobre su prevalencia en España. El objetivo de este trabajo fue conocer su prevalencia en la provincia de Cádiz. Métodos: Se estudió el consumo del grupo terapéutico H03AA realizado en receta oficial por las unidades de Atención Primaria (AP de Cádiz, durante el año 2012. La prevalencia se estimó mediante tres métodos: la Dosis Diaria Definida (DDD, la Dosis Diaria Prescrita (DDP y el Registro Pacientes en Tratamiento (RPT. Los resultados se presentaron según sexo y edad con intervalos de confianza del 95%. Resultados: La prevalencia de HT durante 2012 en población mayor de 15 años de la provincia fue del 1,36% (IC95: 1,33%-1,38% mediante DDD, del 2,60% (IC95: 2,54%-2,66% mediante DDP y del 3,10% (IC95: 2,85%-2,93% mediante RPT. La mediana de edad fue de 56 años (rango intercuartílico 43 a 68 años. La prevalencia (RPT por sexo fue de 0,75% en hombres y 5,36% en mujeres [OR 7,26 (IC95: 7,02-7,52], siendo del 9,35% la correspondiente a mujeres de 51 a 70 años. Conclusiones: El método de estimación por rptdemuestra ser una herramienta más válida que el método DDD para evaluar la prevalencia de HT. El HT muestra, en nuestra provincia una prevalencia elevada con mayor afectación del sexo femenino.

  20. Infection rates of pentastomids on lizards in urban habitats in the Brazilian northeast Níveis de infecção por pentastomídeos em lagartos de habitats urbanos no nordeste brasileiro

    Directory of Open Access Journals (Sweden)

    WO. Almeida

    2008-11-01

    Full Text Available The rates of pentastomid infections in the syntopic lizards Hemidactylus mabouia and Tropidurus hispidus inhabiting buildings at the Federal University of Paraiba, in João Pessoa, NE Brazil were examined. A total of 30 specimens of Hemidactylus mabouia and 55 specimens of Tropidurus hispidus were examined. The animals were sacrificed by freezing and then fixed and conserved in 70% alcohol. Analyses of the respiratory tract of Hemidactylus mabouia demonstrated that these lizards were infected by Raillietiella frenatus at a rate of 20% (6/30 with an average infection intensity of 1.33 ± 0.21, 1-2. None of the specimens of T. hispidus analyzed were infected. Hemidactylus mabouia and R. frenatus are of African origin and it is possible that there are specific relationships, or preferences, between these two species.Foram analisadas as taxas de infecção por pentastomídeos nos lagartos simpátricos Hemidactylus mabouia e Tropidurus hispidus, habitando prédios da Universidade Federal da Paraíba, em João Pessoa, Nordeste do Brasil. Para tanto, foram examinados 30 espécimes de Hemidactylus mabouia e 55 de Tropidurus hispidus. Os espécimes coletados foram eutanizados por congelamento, fixados e conservados em álcool 70%. A análise do trato respiratório dos Hemidactylus mabouia mostrou que estavam infectados por Raillietiella frenatus, com prevalência de 20% (6/30 e intensidade de infecção média de 1,33 ± 0,21, 1-2. Nenhum espécime de T. hispidus analisado estava infectado. Hemidactylus mabouia e R. frenatus possuem origem africana e é possível que haja alguma relação de especificidade ou preferência entre essas espécies.

  1. Prevalence of mood disorders and utility of the PRIME-MD in patients undergoing radiation therapy

    International Nuclear Information System (INIS)

    Leopold, Kenneth A.; Ahles, Tim A.; Walch, Susan; Amdur, Robert J.; Mott, Leila A.; Wiegand-Packard, Linda; Oxman, Thomas E.

    1998-01-01

    Purpose: To validate a short, structured interview procedure that allows practicing oncologists to quickly and reliably identify mood disorders in their patients, and to estimate the prevalence and types of mood disorders in a radiation therapy patient setting, noting relationships between mood disorders and patient characteristics. Methods: Consecutive, eligible adult patients from the practices of two radiation oncologists were administered the Primary Care Evaluation of Mental Disorders (PRIME-MD) by the treating physician. A subset of these patients was also evaluated with the SCID, administered by trained mental health care personnel. Agreement between the two instruments was examined using the kappa statistic. Prevalence of mood disorders was determined from the PRIME-MD. The significance of relationships between patient characteristics and mood disorders was examined by chi-square and ANOVA analysis, and subsequently by multivariate logistic regression analysis. Results: One hundred twenty-two patients were studied. Fifty-three of these were administered the SCID. Agreement between the two instruments was very good (kappa = 0.70). A diagnosis of a depressive or anxiety disorder by the PRIME-MD was made in 59 of the 122 patients (48%, 95% confidence interval = 39%, 58%). Multivariate analysis showed that a diagnosis of a depressive mood disorder was significantly related to pain intensity and prior history of depression. Conclusion: We have demonstrated the validity and feasibility of the PRIME-MD administered by oncologists in making diagnoses of mood disorders. The prevalence of mood disorders in our set of patients undergoing a course of RT was nearly 50%. Future studies should describe the natural history of these disorders, and determine optimal intervention strategies

  2. An improved axenic system for studying pre-infection development of the parasitic plant Orobanche ramosa.

    Science.gov (United States)

    González-Verdejo, Clara Isabel; Barandiaran, Xabier; Moreno, Maria Teresa; Cubero, Jose Ignacio; Di Pietro, Antonio

    2005-11-01

    Broomrapes (Orobanche spp.) are holoparasitic weeds that cause devastating losses in many economically important crops. The molecular mechanisms that control early stages of host infection in Orobanche are poorly understood, partly due to the lack of experimentally tractable in vitro systems that allow the efficient application of molecular tools. Here an improved axenic system for the analysis of pre-infection stages in O. ramosa in the absence of the host plant is described. An optimized protocol for seed disinfection, based on formaldehyde, was developed. Orobanche ramosa seeds were conditioned in Petri dishes with filter paper, stimulated by addition of the synthetic strigol analogue GR24, and the percentage of germination as well as attachment-organ formation was determined. Treatment of O. ramosa seeds with tobacco-root exudate or with GR24 resulted in highly reproducible germination rates around 70 %. A conditioning period of 8 d was both necessary and sufficient to allow optimal germination in response to GR24. Conditioned seeds that were dehydrated for several months remained fully responsive to GR24 without the need of a new conditioning period. Treatments as short as 5 min with GR24 were sufficient to fully and irreversibly induce the seed germination response. Approximately half of the germinated seeds initiated attachment-organ development. Similar rates of attachment organ induction were also detected in the rare cases of seeds that had germinated spontaneously on water. The results suggest that the conditioning period produces persistent changes in the seeds required for responsiveness to external stimulants. The rapid action of GR24 suggests that it may act via a receptor-mediated signalling mechanism. While germination in O. ramosa is induced by exogenous stimuli, attachment organ differentiation appears to be triggered by unknown endogenous signals. The new in vitro culture system will have useful applications for the molecular analysis of early

  3. Image-based modelling of lateral magma flow: the Basement Sill, Antarctica.

    Science.gov (United States)

    Petford, Nick; Mirhadizadeh, Seyed

    2017-05-01

    The McMurdo Dry Valleys magmatic system, Antarctica, provides a world-class example of pervasive lateral magma flow on a continental scale. The lowermost intrusion (Basement Sill) offers detailed sections through the now frozen particle microstructure of a congested magma slurry. We simulated the flow regime in two and three dimensions using numerical models built on a finite-element mesh derived from field data. The model captures the flow behaviour of the Basement Sill magma over a viscosity range of 1-10 4  Pa s where the higher end (greater than or equal to 10 2  Pa s) corresponds to a magmatic slurry with crystal fractions varying between 30 and 70%. A novel feature of the model is the discovery of transient, low viscosity (less than or equal to 50 Pa s) high Reynolds number eddies formed along undulating contacts at the floor and roof of the intrusion. Numerical tracing of particle orbits implies crystals trapped in eddies segregate according to their mass density. Recovered shear strain rates (10 -3 -10 -5  s -1 ) at viscosities equating to high particle concentrations (around more than 40%) in the Sill interior point to shear-thinning as an explanation for some types of magmatic layering there. Model transport rates for the Sill magmas imply a maximum emplacement time of ca 10 5 years, consistent with geochemical evidence for long-range lateral flow. It is a theoretically possibility that fast-flowing magma on a continental scale will be susceptible to planetary-scale rotational forces.

  4. A difference in systolic blood pressure between arms is a novel predictor of the development and progression of diabetic nephropathy in patients with type 2 diabetes.

    Science.gov (United States)

    Okada, Hiroshi; Fukui, Michiaki; Tanaka, Muhei; Matsumoto, Shinobu; Iwase, Hiroya; Kobayashi, Kanae; Asano, Mai; Yamazaki, Masahiro; Hasegawa, Goji; Nakamura, Naoto

    2013-10-01

    Recent studies have suggested that a difference in systolic blood pressure (SBP) between arms is associated with both vascular disease and mortality. The aim of this study was to investigate the relationship between a difference in SBP between arms and change in urinary albumin excretion or development of albuminuria in patients with type 2 diabetes. We measured SBP in 408 consecutive patients with type 2 diabetes, and calculated a difference in SBP between arms. We performed follow-up study to assess change in urinary albumin excretion or development of albuminuria, mean interval of which was 4.6 ± 1.7 years. We then evaluated the relationship of a difference in SBP between arms to diabetic nephropathy using multiple regression analysis and multiple Cox regression model. Multiple regression analyses demonstrated that a difference in SBP between arms was independently associated with change in urinary albumin excretion (β = 0.1869, P = 0.0010). Adjusted Cox regression analyses demonstrated that a difference in SBP between arms was associated with an increased hazard of development of albuminuria; hazard ratio was 1.215 (95% confidence interval 1.077-1.376). Moreover, the risk of development of albuminuria was increased in patients with a difference in SBP of equal to or more than 10 mmHg between arms; hazard ratio was 4.168 (95% confidence interval 1.478-11.70). A difference in SBP between arms could be a novel predictor of the development and progression of diabetic nephropathy in patients with type 2 diabetes. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  5. Defective quiescence entry promotes the fermentation performance of bottom-fermenting brewer's yeast.

    Science.gov (United States)

    Oomuro, Mayu; Kato, Taku; Zhou, Yan; Watanabe, Daisuke; Motoyama, Yasuo; Yamagishi, Hiromi; Akao, Takeshi; Aizawa, Masayuki

    2016-11-01

    One of the key processes in making beer is fermentation. In the fermentation process, brewer's yeast plays an essential role in both the production of ethanol and the flavor profile of beer. Therefore, the mechanism of ethanol fermentation by of brewer's yeast is attracting much attention. The high ethanol productivity of sake yeast has provided a good basis from which to investigate the factors that regulate the fermentation rates of brewer's yeast. Recent studies found that the elevated fermentation rate of sake Saccharomyces cerevisiae species is closely related to a defective transition from vegetative growth to the quiescent (G 0 ) state. In the present study, to clarify the relationship between the fermentation rate of brewer's yeast and entry into G 0 , we constructed two types of mutant of the bottom-fermenting brewer's yeast Saccharomyces pastorianus Weihenstephan 34/70: a RIM15 gene disruptant that was defective in entry into G 0 ; and a CLN3ΔPEST mutant, in which the G 1 cyclin Cln3p accumulated at high levels. Both strains exhibited higher fermentation rates under high-maltose medium or high-gravity wort conditions (20° Plato) as compared with the wild-type strain. Furthermore, G 1 arrest and/or G 0 entry were defective in both the RIM15 disruptant and the CLN3ΔPEST mutant as compared with the wild-type strain. Taken together, these results indicate that regulation of the G 0 /G 1 transition might govern the fermentation rate of bottom-fermenting brewer's yeast in high-gravity wort. Copyright © 2016 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  6. Interfacial electron-transfer equilibria and flat-band potentials of α-Fe2O3 and TiO2 colloids studied by pulse radiolysis

    International Nuclear Information System (INIS)

    Dimitrijevic, N.M.; Savic, D.; Micic, O.I.; Nozik, A.J.

    1984-01-01

    The kinetics and equilibria of electron transfer between methylviologen cation radicals and α-Fe 2 O 3 or TiO 2 colloidal particles were studied with the pulse-radiolysis technique. The rates of electron transfer to both colloids are lower than those predicted for a diffusion-controlled reaction. For higher pHs (TiO 2 , pH > 2; α-Fe 2 O 3 , pH > 9) the established equilibrium MV + in equilibrium MV 2+ + (e - )/sub coll/ is strongly influenced by the MV 2+ concentration and pH. The MV + equilibrium concentration can be exploited to derive the flat-band potential of the semiconductor colloids. The method for determining the flat-band potential of the particles is independent of whether the injected electrons are free or trapped, and whether the electrons raise the bulk Fermi level toward the conduction band or just produce a space charge. The flat-band potentials for both colloids appear to be somewhat more negative (-0.1 to -0.2 V) than the corresponding single-crystal electrodes. Also, the flat-band potentials become slightly more negative with increasing radiation dose (initial MV + concentration). The effect of absorbed radiation dose is explained by the corresponding changes in the ratio of oxidized to reduced forms of the redox couple, which in turn changes the adsorbed ionic charge on the semiconductor surface. For colloidal particles of TiO 2 stabilized by poly(vinyl alcohol) (PVA), the flat-band potentials were almost the same as those for PVA-free TiO 2 sols. The decrease of particle diameter from 800 to 70 A does not affect the value of the flat-band potentials for TiO 2 and α-Fe 2 O 3 colloids. 28 references, 9 figures

  7. Physical work environment: testing an expanded model of job satisfaction in a sample of registered nurses.

    Science.gov (United States)

    Djukic, Maja; Kovner, Christine; Budin, Wendy C; Norman, Robert

    2010-01-01

    The impact of personal, organizational, and economic factors on nurses' job satisfaction have been studied extensively, but few studies exist in which the effects of physical work environment--including perceptions of architectural, interior design, and ambient features on job satisfaction-are examined. The purpose of this study was to examine the effect of perceived physical work environment on job satisfaction, adjusting for multiple personal, organizational, and economic determinants of job satisfaction. A cross-sectional, predictive design and a Web-based survey instrument were used to collect data from staff registered nurses in a large metropolitan hospital. The survey included 34 questions about multiple job satisfaction determinants, including 18 Likert-type measures with established good validity (comparative fit index = .97, Tucker-Lewis index = .98, root mean square error of approximation = .06) and reliability (r ≥ .70). A response rate of 48.5% resulted in a sample of 362, with 80% power to detect a medium effect of perceived physical environment on job satisfaction. On average, nurses had negative perceptions of physical work environment (M = 2.9, SD = 2.2). Although physical environment was related positively to job satisfaction (r =.256, p = .01) in bivariate analysis, in ordered probit regression, no effect of physical work environment on job satisfaction was found. In future studies, this relationship should be examined in larger and more representative samples of nurses. Qualitative methods should be used to explore how negatively perceived physical work environment impacts nurses. Rebuilding of U.S. hospitals, with a planned investment of $200 billion without considering how physical environment contributes to nurse work outcomes, threatens to exacerbate organizational nurse turnover.

  8. Identification of the major allergens of Indian scad (Decapterus russelli).

    Science.gov (United States)

    Misnan, Rosmilah; Murad, Shahnaz; Jones, Meinir; Taylor, Graham; Rahman, Dinah; Arip, Masita; Abdullah, Noormalin; Mohamed, Jamaluddin

    2008-12-01

    The purpose of this study was to characterize major allergens of Indian scad (Decapterus russelli) which is among the most commonly consumed fish in Malaysia. Raw and cooked extracts of the fish were prepared. Protein profiles and IgE binding patterns were produced by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting using sera from subjects with fish allergy. The major allergens of the fish were then identified by two-dimensional electrophoresis (2-DE), followed by mass spectrometry of the peptide digests. The SDS-PAGE of the raw extract revealed 27 protein fractions over a wide molecular weight range, while the cooked extract demonstrated only six protein fractions. The 1-DE immunoblotting detected 14 IgE-binding proteins, with a molecular weight range from 90 to fish. The approximately 12 kDa band was a heat-resistant protein while the approximately 51 and 46 kDa proteins were sensitive to heat. The 2-DE gel profile of the raw extract demonstrated > 100 distinct protein spots and immunoblotting detected at least 10 different major IgE reactive spots with molecular masses as expected and isoelectric point (pI) values ranging from 4.0 to 7.0. A comparison of the major allergenic spot sequences of the 12 kDa proteins with known protein sequences in databases revealed extensive similarity with fish parvalbumin. In conclusion, this study demonstrated that a parvalbumin which is similar to Gad c 1 is the major allergen of Indian scad. Interestingly, we also detected heat-sensitive proteins as major allergenic components in our fish allergy patients.

  9. The sport of orienteering: performance of physically active people who partake in leisure activities but have no experience in this modality

    Directory of Open Access Journals (Sweden)

    Tadeu Celestino

    2012-01-01

    Full Text Available En las últimas décadas, el número de practicantes de deporte de orientación ha aumentado de tal modo que actualmente se piensa que ya sobrepasa un millón en más de 58 países (Eccles, Walsh & Ingledew, 2006. La presente investigación pretendió identificar las representaciones que sobre el deporte de orientación tienen practicantes de actividades físicas y deportivas diversas, en contexto de ocio, sin experiencia en la práctica de la orientación. El estudio tuvo como muestra 20 individuos con edades comprendidas entre los 25 y los 70 años, de ambos géneros y residentes en la ciudad de Viseu, Portugal. Para este estudio fueron realizadas entrevistas semiestructuradas (Ghiglione & Matalon, 2001. La técnica de tratamiento de la información utilizada fue el "análisis de contenido" (Bardin, 2008. Los entrevistados consideran el deporte de orientación una actividad utilitaria, desarrollada en el ámbito del deporte de naturaleza. La mayoría desconocía por completo la orientación como modalidad deportiva, debidamente organizada, lo que demuestra la juventud de la modalidad en Portugal y el largo camino que aún tendrá que transcurrir. Las razones que los entrevistados presentan a la hora de justificar la práctica de esta modalidad están relacionadas con el hecho de desarrollarse en contacto con la naturaleza, promocionar la conjunción entre las dimensiones física y cognitiva, constituirse como alternativa de práctica deportiva de ocio, que contribuye a la formación global de los individuos y es asequible a todos.

  10. Advanced nanoimprint patterning for functional electronics and biochemical sensing

    Science.gov (United States)

    Wang, Chao

    Nano-fabrication has been widely used for a variety of disciplines, including electronics, material science, nano-optics, and nano-biotechnology. This dissertation focuses on nanoimprint lithography (NIL) based novel nano-patterning techniques for fabricating functional structures, and discusses their applications in advanced electronics and high-sensitivity molecular sensing. In this dissertation, examples of using nano-fabricated structures for promising electronic applications are presented. For instance, 10 nm and 18 nm features are NIL-fabricated for Si/SiGe heterojunction tunneling transistors and graphene nano-ribbon transistors, using shadow evaporation and line-width shrinking techniques, respectively. An ultrafast laser melting based method is applied on flexible plastic substrates to correct defects of nano-features. Nano-texturing of sapphire substrate is developed to improve the light extraction of GaN light emitting diodes (LEDs) by 70 %. A novel multi-layer nano-patterned Si-mediated catalyst is discovered to grow straight and uniform Si nanowires with optimized properties in size, location, and crystallization on amorphous SiO2 substrate. Nano-structures are also functionalized into highly sensitive bio-chemical sensors. Plasmonic nano-bar antenna arrays are demonstrated to effectively sense infrared molecules >10 times better than conventional plasmonic sensors. As small as 20 nm wide nano-channel fluidic devices are developed to linearize and detect DNA molecules for potential DNA sequencing. An integrated fluidic system is built to incorporate plasmonic nano-structures for 30X-enhanced fluorescence detection of large DNA molecules.

  11. Improving consent in patients undergoing surgery for fractured neck of femur.

    Science.gov (United States)

    Thiruchandran, Gajendiran; McKean, Andrew R; Rudran, Branavan; Imam, Mohamed A; Yeong, Keefai; Hassan, Abdel

    2018-05-02

    Background Neck of femur fractures and their subsequent operative fixation are associated with high rates of perioperative morbidity and mortality. Consenting in this setting is suboptimal with the Montgomery court ruling changing the perspective of consent. This quality improvement project assessed the adequacy of consenting against British Orthopaedic Association-endorsed guidance and implemented a series of changes to improve the documentation of risks associated with surgery for fractured neck of femur. Methods Seventy consecutive patients who underwent any operative fixation of a neck of femur fracture were included over a 6-month period at a single centre. Patients unable to consent or without electronic notes were excluded. Consent forms were analysed and the documented potential risks or complications associated with surgery were compared to British Orthopaedic Association-endorsed guidance. A series of changes (using the plan, do study, act (PDSA) approach) was implemented to improve the adequacy of consent. Results Documentation of four out of 12 potential risks or complications was recorded in <50% of cases for patients with intracapsular fractures (n=35), and documentation of seven out of 12 potential risks or complications was recorded in <50% of cases for patients with extracapsular fractures (n=35). Re-audit following raising awareness and attaching consent guidance showed 100% documentation of potential risks or complications in patients with intracapsular and extracapsular fractures (n=70). A neck of femur fracture-specific consent form has been implemented which will hopefully lead to sustained improvement. Conclusions Consenting patients with fractured neck of femur for surgery in the authors' unit was suboptimal when compared to British Orthopaedic Association-endorsed consent guidance. This project has shown that ensuring such guidance is readily available has improved the adequacy of consent. The authors hope that introduction of a neck of

  12. Induction of Heat Shock Protein 70 Ameliorates Ultraviolet-Induced Photokeratitis in Mice

    Directory of Open Access Journals (Sweden)

    Yukihiro Horie

    2013-01-01

    Full Text Available Acute ultraviolet (UV B exposure causes photokeratitis and induces apoptosis in corneal cells. Geranylgeranylacetone (GGA is an acyclic polyisoprenoid that induces expression of heat shock protein (HSP70, a soluble intracellular chaperone protein expressed in various tissues, protecting cells against stress conditions. We examined whether induction of HSP70 has therapeutic effects on UV-photokeratitis in mice. C57 BL/6 mice were divided into four groups, GGA-treated (500 mg/kg/mouse and UVB-exposed (400 mJ/cm2, GGA-untreated UVB-exposed (400 mJ/cm2, GGA-treated (500 mg/kg/mouse but not exposed and naive controls. Eyeballs were collected 24 h after irradiation, and corneas were stained with hematoxylin and eosin (H&E and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL. HSP70, reactive oxygen species (ROS production, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB and protein kinase B (Akt expression were also evaluated. Irradiated corneal epithelium was significantly thicker in the eyes of mice treated with GGA compared with those given the vehicle alone (p < 0.01. Significantly fewer TUNEL-positive cells were observed in the eyes of GGA-treated mice than controls after irradiation (p < 0.01. Corneal HSP70 levels were significantly elevated in corneas of mice treated with GGA (p < 0.05. ROS signal was not affected by GGA. NF-κB activation was reduced but phospho-(Ser/Ther Akt substrate expression was increased in corneas after irradiation when treated with GGA. GGA-treatment induced HSP70 expression and ameliorated UV-induced corneal damage through the reduced NF-κB activation and possibly increased Akt phosphorilation.

  13. A single center 26-year experience with treatment of esophageal achalasia: is there an optimal method?

    Science.gov (United States)

    Pastor, Aimee C; Mills, Jessica; Marcon, Margaret A; Himidan, Sharifa; Kim, Peter C W

    2009-07-01

    Treatment modalities for achalasia are evolving and remain controversial. Herein, we report the relative efficacy and outcomes after dilatation or myotomy in children with achalasia. A retrospective analysis of all children treated for achalasia at a tertiary center from 1981 to 2007 was performed (n = 40). Demographics, presenting symptoms, perioperative parameters, and outcomes were analyzed using t tests and chi(2) statistics. Thirty patients were initially treated by esophageal dilatation (ED), whereas 10 were treated by laparoscopic or open Heller myotomy (HM). Both groups were similar with respect to age (10.6 vs 12.4 years; P = .19). There were 18 males and 12 females in the ED group, compared to 5 males and 5 females in the HM group (P = .72). Mean duration of symptoms before diagnosis, including dysphagia, vomiting, food sticking, chest pain, and weight loss, was 15.9 months for ED and 10.7 months for HM (P = .41). Mean time from diagnosis to initial intervention was 76 days in ED vs 86 days in HM (P = .78). Subsequent interventions by myotomy or both dilatation and myotomy were required in 9 (30%) of 30 patients in the ED group and 2 (20%) of 10 patients in the HM group (P = .70). A clear transition from open to laparoscopic approach occurred between 1995 and 2001. Mean operating times were comparable (186.3 vs 156.0 minutes; P = .48). Of 14 laparoscopic myotomies, 11 (79%) had fundoplication, and 2 (18%) of the 11 were converted to open procedure. Intraoperative mucosal perforation rates were similar between open and laparoscopic groups (17% vs 18%). At follow-up, 32% of ED patients vs 43% HM had complete symptom relief (mean follow-up duration, 75.2 months; SD, 196.5). Both dilatation and myotomy are effective immediate treatment of achalasia. A clear transition to and preference for laparoscopic approach has occurred in the treatment of achalasia in children.

  14. Blood cadmium levels are associated with a decline in lung function in males

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Chang-Mo [Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul 130-701 (Korea, Republic of); The Korea Central Cancer Registry, National Cancer Center, Goyang (Korea, Republic of); Oh, In-Hwan; Lee, Jong-Keun [Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Park, Yoon Hyung [Departments of Preventive Medicine, School of Medicine, Soonchunhyang University, Seoul (Korea, Republic of); Choe, Bong-Keun; Yoon, Tai-Young [Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Choi, Joong-Myung, E-mail: jmchoi@khu.ac.kr [Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul 130-701 (Korea, Republic of)

    2014-07-15

    Background: Cadmium exposure was found to cause a decline in lung function among the general population, but these findings were limited to smokers and gender differences were not explored. Objectives: To examine the relationship between cadmium and chronic obstructive pulmonary disease (COPD) according to gender and smoking status in Korea. Methods: Cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2011 were analyzed. COPD was defined by a pre-bronchodilator forced expiratory volume in 1 s divided by forced vital capacity of <0.70. A logistic regression model was used to elucidate the association between blood cadmium levels and COPD according to gender and smoking status. Results: Among 3861 eligible participants, 3622 were included in the analysis. The prevalence of COPD demonstrated an increasing trend in males (P for trend<0.001), but not in females (P for trend=0.67). After adjusting for covariates, a higher blood cadmium level, but within the normal range, was associated with COPD in males, including those who had never-smoked (P for trend <0.001 and P for trend=0.008). However, a higher blood cadmium level was not significantly associated with COPD in females, including those who had never smoked (P for trend=0.39 and P for trend=0.43). Conclusions: A higher blood cadmium level, within the normal range, was associated with COPD in males, including those who had never smoked. However, there was no significant association between blood cadmium levels and COPD in females. - Highlights: • Elevated blood cadmium level is associated with chronic obstructive pulmonary disease in male. • This association can be seen even in never smoked male. • However, this association is present only in male, but not in female.

  15. Purification of a myotoxin from the toadfish Thalassophryne maculosa (Günter) venom.

    Science.gov (United States)

    Sosa-Rosales, J I; D'Suze, G; Salazar, V; Fox, J; Sevcik, C

    2005-02-01

    Venom was milked by gently pressing the base of the opercular and dorsal fin spines. Three fractions were obtained by molecular exclusion high pressure liquid chromatography (HPLC) (Protein Pak 125SW, Millipore Corporation) column, but only the last one with 22.7 min retention time (rt) was biological active (TmPP-22.7). This fraction was rechromatographed on reversed phase HPLC chlorobutylsilane columns (C4, Vydac) nine fractions were obtained, but only one (TmC4-47.2) with 47.2 min rt was biologically active. MALD-TOF mass analysis was carried out on two samples of TmC-47.2 and the results were 15,161.36 and 15,154.70 a.m.u., respectively. Raw venom (1040 microg/ml) depolarised frog (Hyla crepitans) muscle irreversibly from -85 (-88, -81) mV (n=20, median and its 95% CI) to -18 (-24, -15) mV (n=24). The biological activity in TmPP-22.7 (38 microg/ml), which depolarised muscle fibres from -79 (-82, -76) mV (n=20) to -63 (-69 -57) mV (n=24). The depolarising fraction was TmC4-47.2 (50 microg/ml) which depolarised muscles from -87 (91, -82) mV (n=33) to -63 (-76 -51) mV (n=53); the depolarising effect at this concentration was completely reversed on washing with normal saline for 2 h. Muscles treated with 1 microM tetrodotoxin (TTX) were depolarised from -80 (-85, -72) mV (n=49) to -44 (-56, -31) mV (n=44) when 100 microg/ml TmC4-47.2 were applied with TTX; washing 130 min with 1 microM TTX repolarised to -59 (-69, -50) mV (n=25). We also present evidence that TmC4-47.2 induces myonecrosis in mice.

  16. Percepción de la lepra y las discapacidades antes del diagnóstico en Recife, Brasil

    Directory of Open Access Journals (Sweden)

    Katia V. de O. Feliciano

    1998-05-01

    Full Text Available Este artículo presenta un estudio de casos y controles realizado en Recife, Brasil, entre noviembre de 1993 y julio de 1994. En él se investigó cómo influyen la percepción y las apreciaciones de los propios pacientes de lepra en el proceso de manejar la enfermedad y en la utilización de los servicios de salud. La muestra estuvo constituida por 183 pacientes de 20 a 70 años de edad, residentes en Recife, que acudieron en busca de un diagnóstico a los servicios de dermatología sanitaria de dos centros de referencia de las regiones politicoadministrativas tercera, cuarta y sexta. Se clasificaron como casos los 64 pacientes que tenían discapacidades o lesiones precursoras de discapacidad; los 119 restantes se consideraron controles. Todos fueron diagnosticados durante el período de la investigación. En el análisis se ajustó según sexo, edad, escolaridad y antecedentes de la enfermedad de Hansen de los pacientes. El estudio reveló la coexistencia de dos tipos de "invisibilidad" de la enfermedad en una zona endémica en expansión: 1 para los pacientes de ambos grupos, la baja frecuencia de modelos explicativos, espontáneos, relacionados con la dolencia, aun en presencia de antecedentes de la enfermedad, y 2 para los profesionales sanitarios, las limitaciones de la detección. Puesto que afectan a las decisiones relacionadas con el manejo individual y colectivo de la enfermedad, esas deficiencias constituyen por sí mismas un factor de riesgo y representan un obstáculo para la eliminación de la lepra como problema de salud pública.

  17. Intervención educativa escolar para prevenir el tabaquismo: evaluación del proceso

    Directory of Open Access Journals (Sweden)

    Leijs Ingrid

    1998-01-01

    Full Text Available FUNDAMENTO: Los datos publicados sobre eficacia de programas escolares para la prevención del tabaquismo son inconsistentes. No está suficientemente estudiado el proveedor de tales programas como variable de confusión. El objetivo de este estudio fue evaluar el proceso de una intervención educativa intraescolar. MÉTODO: Líderes estudiantiles y profesores, entrenados y con guías, desarrollaron un programa de base social. Se encuestó aleatoriamente a 2 alumnos por cada aula, mediante cuestionario validado y pilotado: 318 niños. Se utilizó el Indice Kappa para medir la fiabilidad, y el Coeficiente de Correlación Intraclase, el de Pearson y el análisis de las diferencias individuales para comparar los datos de ajuste al programa, proporcionados por alumnos y profesores. RESULTADOS: La media de ajuste por aula fue 30,07 puntos (48 =100% de ajuste. El 26% de los niños no pudo citar una alternativa a las ventajas de fumar, 71,7% desconocía la frecuencia de consumo en adultos y 19,5% no pudo evocar ningún truco propio de la publicidad del tabaco. Menos de la mitad realizó un sociodrama sobre el tema, como era preceptivo. El CCI fue 0,21, Pearson 0,25 (p = 0,02 y el intervalo de concordancia entre las calificaciones de profesores y alumnos fue de 6,93 puntos (-1,70 a 5,23. CONCLUSIONES: El ajuste de la implementación al modelo de programa propuesto fue insuficiente. Encontramos escasa correspondencia entre la autocalificación del profesorado y la puntuación alcanzada por los alumnos en el ajuste al programa. La evaluación del proceso es esencial para interpretar correctamente la evaluación del impacto.

  18. 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, Monica Pires; Souza, Sergio Augusto Lopes de; Lopes, Flavia Paiva Proenca Lobo; Rosado-de-Castro, Paulo Henrique; Fonseca, Lea Mirian Barbosa da; Gutfilen, Bianca [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Faculdade de Medicina. Hospital Universitario Clementino Fraga Filho, Departamento de Radiologia

    2013-05-01

    Objective: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of {sup 99m}Tc-thymine in mammary lesions. Methods: A total of 45 patients were included in this study. Thirty-three patients (73%) were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results. Results: The majority of patients (64.4%) had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with {sup 99m}Tc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively, and an accuracy of 82.2%. Conclusions: The results of this study are consistent with those previously reported by other authors. The good specificity and high negative predictive value of this technique and the absence of uptake in the heart indicate that it may be a promising complementary method in clinical practice and that it may contribute to reducing unnecessary benign biopsies. (author)

  19. El impacto psicosocial de la violencia en San Salvador

    Directory of Open Access Journals (Sweden)

    Cruz José Miguel

    1999-01-01

    Full Text Available En este estudio se busca lograr dos objetivos: primero, describir los niveles de victimización de la población salvadoreña a causa de la violencia delictiva y el tipo de población más afectada por ella; segundo, averiguar si estos niveles de victimización están relacionados con la presencia de normas, actitudes y comportamientos que favorecen la aparición de la violencia. Para ello se utilizaron los datos del proyecto ACTIVA de El Salvador, que fue realizado por el Instituto Universitario de Opinión Pública entre los meses de octubre y noviembre de 1996 con una muestra de 1 290 entrevistas personales, presuntamente representativa de las personas entre los 18 y 70 años de edad que residen en el Área Metropolitana de San Salvador. La muestra se obtuvo mediante un muestreo probabilístico y multietápico. Los resultados revelan que el nivel de victimización por la violencia es bastante alto en San Salvador y que afecta sobre todo a los hombres y a los jóvenes, y sugieren que las personas que han sido víctimas de agresiones graves suelen mostrar con más frecuencia que el resto normas de justificación y aprobación del uso de la violencia, inclinación por el uso de armas, y conductas de agresión hacia otras personas.

  20. Undetected cognitive impairment and decision-making capacity in patients receiving hospice care.

    Science.gov (United States)

    Burton, Cynthia Z; Twamley, Elizabeth W; Lee, Lana C; Palmer, Barton W; Jeste, Dilip V; Dunn, Laura B; Irwin, Scott A

    2012-04-01

    : Cognitive dysfunction is common in patients with advanced, life-threatening illness and can be attributed to a variety of factors (e.g., advanced age, opiate medication). Such dysfunction likely affects decisional capacity, which is a crucial consideration as the end-of-life approaches and patients face multiple choices regarding treatment, family, and estate planning. This study examined the prevalence of cognitive impairment and its impact on decision-making abilities among hospice patients with neither a chart diagnosis of a cognitive disorder nor clinically apparent cognitive impairment (e.g., delirium, unresponsiveness). : A total of 110 participants receiving hospice services completed a 1-hour neuropsychological battery, a measure of decisional capacity, and accompanying interviews. : In general, participants were mildly impaired on measures of verbal learning, verbal memory, and verbal fluency; 54% of the sample was classified as having significant, previously undetected cognitive impairment. These individuals performed significantly worse than the other participants on all neuropsychological and decisional capacity measures, with effect sizes ranging from medium to very large (0.43-2.70). A number of verbal abilities as well as global cognitive functioning significantly predicted decision-making capacity. : Despite an absence of documented or clinically obvious impairment, more than half of the sample had significant cognitive impairments. Assessment of cognition in hospice patients is warranted, including assessment of verbal abilities that may interfere with understanding or reasoning related to treatment decisions. Identification of patients at risk for impaired cognition and decision making may lead to effective interventions to improve decision making and honor the wishes of patients and families.

  1. Controlling dental enamel-cavity ablation depth with optimized stepping parameters along the focal plane normal using a three axis, numerically controlled picosecond laser.

    Science.gov (United States)

    Yuan, Fusong; Lv, Peijun; Wang, Dangxiao; Wang, Lei; Sun, Yuchun; Wang, Yong

    2015-02-01

    The purpose of this study was to establish a depth-control method in enamel-cavity ablation by optimizing the timing of the focal-plane-normal stepping and the single-step size of a three axis, numerically controlled picosecond laser. Although it has been proposed that picosecond lasers may be used to ablate dental hard tissue, the viability of such a depth-control method in enamel-cavity ablation remains uncertain. Forty-two enamel slices with approximately level surfaces were prepared and subjected to two-dimensional ablation by a picosecond laser. The additive-pulse layer, n, was set to 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70. A three-dimensional microscope was then used to measure the ablation depth, d, to obtain a quantitative function relating n and d. Six enamel slices were then subjected to three dimensional ablation to produce 10 cavities, respectively, with additive-pulse layer and single-step size set to corresponding values. The difference between the theoretical and measured values was calculated for both the cavity depth and the ablation depth of a single step. These were used to determine minimum-difference values for both the additive-pulse layer (n) and single-step size (d). When the additive-pulse layer and the single-step size were set 5 and 45, respectively, the depth error had a minimum of 2.25 μm, and 450 μm deep enamel cavities were produced. When performing three-dimensional ablating of enamel with a picosecond laser, adjusting the timing of the focal-plane-normal stepping and the single-step size allows for the control of ablation-depth error to the order of micrometers.

  2. Assessing peristomal skin changes in ostomy patients: validation of the Ostomy Skin Tool.

    Science.gov (United States)

    Jemec, G B; Martins, L; Claessens, I; Ayello, E A; Hansen, A S; Poulsen, L H; Sibbald, R G

    2011-02-01

    Peristomal skin problems are common and are treated by a variety of health professionals. Clear and consistent communication among these professionals is therefore particularly important. The Ostomy Skin Tool (OST) is a new assessment instrument for the extent and severity of peristomal skin conditions. Formal tests of reliability and validity are necessary for its use in clinical practice, research, and education. To estimate inter- and intra nurse assessment variability of the OST and validity by comparison to a 'gold standard' (GS) defined by an expert panel. Thirty photographs of peristomal skin were presented twice to 20 ostomy care nurses--10 from Denmark (DK) and 10 from Spain (ES)--to determine intra- and inter nurse assessment variability. The same photographs were presented to an international group of experts (dermatologist and ostomy care nurses), to establish a GS for comparison and validation of the results. A high intra-nurse assessment agreement, κ=0·84, was found with no differences in the intra-nurse assessments from the two groups of nurses (DK and ES). The inter-nurse assessment agreement was 'moderate to good', κ=0·54, with the agreement between the experts higher, κ=0·70. A high correlation between the scores from the nurses and the GS were seen in the lower part of the two scales [Discoloration, Erosion, Tissue overgrowth (DET) score<7)]. The study supported the validity of the OST. It is suggested that a categorical scale can be used to illustrate the severity of the DET scores. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.

  3. Manifestations, acquisition and diagnostic categories of dental fear in a self-referred population.

    Science.gov (United States)

    Moore, R; Brødsgaard, I; Birn, H

    1991-01-01

    This study aimed to clarify how manifestations and acquisition relate to diagnostic categories of dental fear in a population of self-referred dental fear patients, since diagnostic criteria specifically related to dental fear have not been validated. DSM III-R diagnostic criteria for phobias were used to compare with four existing dental fear diagnostic categories, referred to as the Seattle system. Subjects were 208 persons with dental fear who were telephone interviewed, of whom a subsample of 155 responded to a mailed Dental Anxiety Scale (DAS), State-Trait Anxiety Inventory and a modified FSS-II Geer Fear Scale (GFS). Personal interviews and a Dental Beliefs Scale of perceived trust and social interaction with dentists were also used to evaluate a subsample of 80 patients selected by sex and high dental fear. Results showed that the majority of the 80 patients (66%), suffered from social embarrassment about their dental fear problem and their inability to do something about it. The largest cause of their fear (84%) was reported to be traumatic dental experiences, especially in childhood (70%). A minority of patients (16%) could not isolate traumatic experiences and had a history of general fearfulness or anxiety. Analysis of GFS data for the 155 subjects showed that fear of snakes and injuries were highest among women; heights and injections among men. Fear of blood was rarely reported. Spearman correlations between GFS individual items and DAS scores indicated functional independence between dental fear and common fears such as blood, injections and enclosures in most cases. Only in specific types of dental fear did these results support Rachman and Lopatka's contention that fears are thought to summate.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. Comorbidity between psychological distress and drug use among patients in treatment centres in Jamaica: implications for policies and programme design

    Directory of Open Access Journals (Sweden)

    Patrice Reid

    2012-01-01

    Full Text Available Esta investigación explora la comorbilidad entre los trastornos psicológicos y el uso de drogas entre los pacientes en centros de tratamiento en Jamaica y las posibles implicaciones para la política y el diseño del programa para los centros de tratamiento. El estudio fue de corte transversal y consistió en 56 pacientes adultos de nacionalidad jamaicana, de 18 a 70 años de edad atendidos en los centros de consumo de sustancias a través de tres parroquias. Los participantes completaron un cuestionario que consta de una versión adaptada de la forma de admisión de la EUALC-CICAD; el intrumento-10 Kessler; y la escala de Apgar-familiar. Los resultados indican que el 10.7% de los pacientes fueron clasificados de tener problemas psicológicos muy graves, el 32.1% categorizados con graves dificultades psicológicas. 66.1% tienen un alto funcionamiento familiar percibida, el 16.1% percibe que la disfunción familiar moderada y el 17.9% percibe que la disfunción familiar severa. El tratamiento predominante recibidos a través de los centros de asesoramiento fue 83.9% y el 83.9% de los pacientes informaron estar satisfechos con su tratamiento. En general, los resultados pueden servir como un trampolín hacia un trabajo más grande que se realiza en la zona, con el fin de capturar una imagen más clara de los fenómenos tal como existe en Jamaica.

  5. Hepatotoxicity in HIV-infected children and adolescents on antiretroviral therapy

    Directory of Open Access Journals (Sweden)

    Ana Cecília Montes Gil

    Full Text Available CONTEXT AND OBJECTIVE: Adverse drug reactions are a significant problem in patients on antiretroviral therapy (ART. We determined liver enzyme elevation frequencies in HIV-infected children and adolescents receiving ART, and their association with risk factors. DESIGN AND SETTING: Cross-sectional study, at the Pediatrics Immunodeficiency Division, University Hospital, Universidade Estadual de Campinas. METHODS: Medical records of 152 children and adolescents (54.6% male; median age 7.48 years were analyzed, with a mean of 2.6 liver enzyme determinations per patient. Clinically, patients were classified in categories N (6, A (29, B (78 and C (39. Serum levels of aspartate aminotransferase and alanine aminotransferase were evaluated. Hepatotoxicity was scored as grade 1 (1.1-4.9 times upper limit of normality, ULN, grade 2 (5.0-9.9 times ULN, grade 3 (10.0-15.0 times ULN and grade 4 (> 15.0 times ULN. To assess hepatotoxicity risk factors, odds ratios (OR and adjusted odds ratios (aOR for age, gender, TCD4+ cell count, viral load and medication usage were calculated. RESULTS: We observed grade 1 hepatotoxicity in 19.7 % (30/152 patients. No cases of grade 2, 3 or 4 were detected. There was a significant association between hepatotoxicity and use of sulfonamides (OR, 3.61; 95% confidence interval (CI, 1.50-8.70; aOR, 3.58; 95% CI, 1.44-8.85 and antituberculous agents (OR, 9.23; 95% CI, 1.60-53.08; aOR, 9.05; 95% CI, 1.48-55.25. No toxicity was associated with ART. CONCLUSIONS: One fifth of patients experienced mild hepatotoxicity, attributed to antituberculous agents and sulfonamides. Our results suggest that ART was well tolerated.

  6. Radiosensitizing Effect of a Phenylbutyrate-Derived Histone Deacetylase Inhibitor in Hepatocellular Carcinoma

    International Nuclear Information System (INIS)

    Lu, Yen-Shen; Chou, Chia-Hung; Tzen, Kai-Yuan; Gao, Ming; Cheng, Ann-Lii; Kulp, Samuel K.; Cheng, Jason Chia-Hsien

    2012-01-01

    Purpose: Radiotherapy is integrated into the multimodal treatment of localized hepatocellular carcinoma (HCC) refractory to conventional treatment. Tumor control remains unsatisfactory and the sublethal effect associates with secondary spread. The use of an effective molecularly targeted agent in combination with radiotherapy is a potential therapeutic approach. Our aim was to assess the effect of combining a phenylbutyrate-derived histone deacetylase (HDAC) inhibitor, AR-42, with radiotherapy in in vitro and in vivo models of human HCC. Methods and Materials: Human HCC cell lines (Huh-7 and PLC-5) were used to evaluate the in vitro synergism of combining AR-42 with irradiation. Flow cytometry analyzed the cell cycle changes, whereas Western blot investigated the protein expressions after the combined treatment. Severe combined immunodeficient (SCID) mice bearing ectopic and orthotopic HCC xenografts were treated with AR-42 and/or radiotherapy for the in vivo response. Results: AR-42 significantly enhanced radiation-induced cell death by the inhibition of the DNA end-binding activity of Ku70, a highly versatile regulatory protein for DNA repair, telomere maintenance, and apoptosis. In ectopic xenografts of Huh-7 and PLC-5, pretreatment with AR-42 significantly enhanced the tumor-suppressive effect of radiotherapy by 48% and 66%, respectively. A similar combinatorial effect of AR-42 (10 and 25 mg/kg) and radiotherapy was observed in Huh-7 orthotopic model of tumor growth by 52% and 82%, respectively. This tumor suppression was associated with inhibition of intratumoral Ku70 activity as well as reductions in markers of HDAC activity and proliferation, and increased apoptosis. Conclusion: AR-42 is a potent, orally bioavailable inhibitor of HDAC with therapeutic value as a radiosensitizer of HCC.

  7. The First Paenibacillus larvae Bacteriophage Endolysin (PlyPl23 with High Potential to Control American Foulbrood.

    Directory of Open Access Journals (Sweden)

    Ana Oliveira

    Full Text Available Endolysins, which are peptidoglycan-degrading enzymes expressed during the terminal stage of the reproduction cycle of bacteriophages, have great potential to control Gram-positive pathogens. This work describes the characterization of a novel endolysin (PlyPl23 encoded on the genome of Paenibacillus larvae phage phiIBB_Pl23 with high potential to control American foulbrood. This bacterial disease, caused by P. larvae, is widespread in North America and Europe and causes important economic losses in apiculture. The restriction to antibiotic residues in honey imposed by the EU legislation hinders its therapeutic use to combat American foulbrood and enforces the development of alternative antimicrobial methods. The new endolysin described herein has an N-acetylmuramoyl-L-alanine amidase catalytic domain and exhibits a broad-spectrum activity against common P. larvae genotypes. Moreover, the enzyme displays high antimicrobial activity in a range of pH that matches environmental conditions (pH between 5.0 and 7.0, showing its feasible application in the field. At pH 7.0, a concentration of 0.2 μM of enzyme was enough to lyse 104 CFU.mL-1 of P. larvae in no more than 2 h. The presence of sucrose and of the substances present in the larvae gut content did not affect the enzyme activity. Interestingly, an increase of activity was observed when PlyPl23 was previously incubated in royal jelly. Furthermore, in vivo safety evaluation assays demonstrated that this enzyme is not toxic to the bee larvae. The present work describes for the first time an endolysin encoded in a P. larvae phage that presents high potential to integrate a commercial product to control the problematic American foulbrood.

  8. High-pressure duo-multichannel soft x-ray spectrometer for tokamak plasma diagnostics

    International Nuclear Information System (INIS)

    Schwob, J.L.; Wouters, A.W.; Suckewer, S.

    1987-03-01

    A high-resolution, time-resolving soft X-ray multichannel spectrometer (SOXMOS) that permits the simultaneous measurement of emission in two different spectral ranges has been developed and tested extensively for tokamak plasma diagnostics. The basic instrument is a high-resolution, interferometrically adjusted, extreme grazing incidence Schwob-Fraenkel duochromator. The instrument is equipped with two multichannel detectors that are adjusted interferometrically and scan along the Rowland circle. Each consists of an MgF 2 coated, funneled microchannel plate, associated with a phosphor screen image intensifier that is coupled to a 1024-element photodiode array by a flexible fibrer optic conduit. The total wavelength coverage of the instrument is 5 to 340 0 A with a measured resolution (FWHM) of about 0.2 A when equipped with a 600 g/mm grating, and 5 to 85 A with a resolution of about 0.06 A using a 2400 g/mm grating. The simultaneous spectral coverage of each detector varies from 15 A at the short wavelength limit to 70 A at the long wavelength limit with the lower dispersion grating. The minimum read-out time for a full spectral portion is 17 ms, but several individual lines can be measured with 1 ms time resolution by selected pixel readout. Higher time resolution can be achieved by replacing one multichannel detector with a single channel electron multiplier detector. Examples of data from the PLT and TFTR tokamaks are presented to illustrate the instrument's versatility, high spectral resolution, and high signal-to-noise ratio even in the 10 A region. 44 refs., 20 figs

  9. Development and evaluation of a social cognitive theory-based instrument to assess correlations for physical activity among people with spinal cord injury.

    Science.gov (United States)

    Wilroy, Jereme; Turner, Lori; Birch, David; Leaver-Dunn, Deidre; Hibberd, Elizabeth; Leeper, James

    2018-01-01

    People with spinal cord injury (SCI) are more susceptible to sedentary lifestyles because of the displacement of physical functioning and the copious barriers. Benefits of physical activity for people with SCI include physical fitness, functional capacity, social integration and psychological well-being. The purpose of this study was to develop and test a social cognitive theory-based instrument aimed to predict physical activity among people with SCI. An instrument was developed through the utilization and modification of previous items from the literature, an expert panel review, and cognitive interviewing, and tested among a sample of the SCI population using a cross-sectional design. Statistical analysis included descriptives, correlations, multiple regression, and exploratory factor analysis. The physical activity outcome variable was significantly and positively correlated with self-regulatory efficacy (r = 0.575), task self-efficacy (r = 0.491), self-regulation (r = 0.432), social support (r = 0.284), and outcome expectations (r = 0.247). Internal consistency for the constructs ranged from 0.82 to 0.96. Construct reliability values for the self-regulation (0.95), self-regulatory efficacy (0.96), task self-efficacy (0.94), social support (0.84), and outcome expectations (0.92) each exceeded the 0.70 a priori criteria. The factor analysis was conducted to seek modifications of current instrument to improve validity and reliability. The data provided support for the convergent validity of the five-factor SCT model. This study provides direction for further development of a valid and reliable instrument for predicting physical activity among people with SCI. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Treatment of water closet flush water for recycle and reuse

    Energy Technology Data Exchange (ETDEWEB)

    Parker, C.E.

    1985-01-01

    Results from the operation of a 37.8 m/sup 3//d extended aeration and sand filtration system in the closed-loop treatment of water closet flush water are presented. The system has operated for four and one-half years at 95 percent recycle. During this period over 30,000 m/sup 3/ of flush water was treated and reused. Water inputs into the recycle system resulted from liquid human wastes plus wastage form potable water uses. Wasted potable water inputs were from wash basins, water fountains and custodial services. Operation of both the biological treatment unit and the pressure sand filter followed acceptable conventional practice. Variations in nitrogen (ammonia, nitrite and nitrate), pH and alkalinity that were observed could be accounted for through fundamental biological, chemical and physical relationships. The pH throughout the entire recycle system varied between 5.5 and 8.4. Recycled water pH rose from a preflush pH of approximately 7.0 to a pH of 8.4 immediately after flushing. The biological unit lowered the pH and functioned between pH values of 5.5 and 7.0. A slight rise in pH between the biological unit (through storage and filtration) and water closets was observed. The predominate biomass in the biological unit was fungi. Biological solids were threadlike; however, they readily separated by gravity settling. Wastage of biological solids from the biological unit in the recycle-reuse system was the same experienced for a comparable biological unit used to treat water closet wastewater that was not recycled. Results from this study have conclusively demonstrated on a full-scale basis the acceptability of using biological oxidation and sand filtration as a treatment train in the reuse of water closet wastewater with a recycle ratio of 20.

  11. Calidad de vida relacionada con la salud y obesidad en un centro de atención primaria

    Directory of Open Access Journals (Sweden)

    Barajas Gutiérrez Miguel Angel

    1998-01-01

    Full Text Available FUNDAMENTO. Evaluar la asociación entre la obesidad y dos aspectos de la calidad de vida relacionada con la salud: autopercepción de salud y bienestar psicológico en pacientes adscritos a un centro de salud. MÉTODOS. Estudio transversal descriptivo sobre 167 pacientes entre 20 y 70 años, con índice de masa corporal ³ 30. Se realizó entrevista clínica para la obtención de las variables sociodemográficas y clínicas de cada paciente y la administración de 2 cuestionarios: 1 Perfil de Salud de Nottingham (PSN y 2 Psychological General Well-Being (PGWB índex. RESULTADOS. Las puntuaciones medias del PSN indicaron un deterioro global moderado de la salud percibida en las pacientes obesas siendo las áreas afectadas "dolor", "movilidad física" y "reacciones emocionales". Las variables asociadas a una peor puntuación fueron el sexo femenino, la edad superior a 50 años, el bajo nivel de estudios y la presencia de patología psiquiátrica o artrosis. La puntuación total media del PGWB indica un deterioro pequeño del bienestar psicológico. El sexo femenino, la ansiedad y el bajo nivel de estudios se asociaron, asimismo, a peores puntuaciones. CONCLUSIONES. En nuestra población, se identifica un perfil de pacientes obesos con mala calidad de vida (mujeres de edad superior a 50 años con bajo nivel de estudios y presencia de patología psiquiátrica o artrosis sobre los que se plantea la conveniencia de realizar una actuación prioritaria.

  12. Fine particulate matter potentiates type 2 diabetes development in high-fat diet-treated mice: stress response and extracellular to intracellular HSP70 ratio analysis.

    Science.gov (United States)

    Goettems-Fiorin, Pauline Brendler; Grochanke, Bethânia Salamoni; Baldissera, Fernanda Giesel; Dos Santos, Analu Bender; Homem de Bittencourt, Paulo Ivo; Ludwig, Mirna Stela; Rhoden, Claudia Ramos; Heck, Thiago Gomes

    2016-12-01

    Exposure to fine particulate matter (PM 2.5 ) air pollution is a risk factor for type 2 diabetes (T2DM). We argue whether the potentiating effect of PM 2.5 over the development of T2DM in high-fat diet (HFD)-fed mice would be related to modification in cell stress response, particularly in antioxidant defenses and 70-kDa heat shock proteins (HSP70) status. Male mice were fed standard chow or HFD for 12 weeks and then randomly exposed to daily nasotropic instillation of PM 2.5 for additional 12 weeks under the same diet schedule, divided into four groups (n = 14-15 each): Control, PM 2.5 , HFD, and HFD + PM 2.5 were evaluated biometric and metabolic profiles of mice, and cellular stress response (antioxidant defense and HSP70 status) of metabolic tissues. Extracellular to intracellular HSP70 ratio ([eHSP72]/[iHSP70]), viz. H-index, was then calculated. HFD + PM 2.5 mice presented a positive correlation between adiposity, increased body weight and glucose intolerance, and increased glucose and triacylglycerol plasma levels. Pancreas exhibited lower iHSP70 expression, accompanied by 3.7-fold increase in the plasma to pancreas [eHSP72]/[iHSP70] ratio. Exposure to PM 2.5 markedly potentiated metabolic dysfunction in HFD-treated mice and promoted relevant alteration in cell stress response assessed by [eHSP72]/[iHSP70], a relevant biomarker of chronic low-grade inflammatory state and T2DM risk.

  13. Estrategias en la prevención de la insuficiencia cardíaca

    Directory of Open Access Journals (Sweden)

    Vukasovig R. José Luis, MD, FACC

    2012-11-01

    Full Text Available Aproximadamente 1 a 2% de la población adulta tiene insuficiencia cardíaca, llegando a valores sobre el 10% en mayores de 70 años de edad. Una adecuada estrategia en la prevención de la Insuficiencia Cardíaca implica tener un manejo precoz en aquellas etiologías que la producen tales como: hipertensión arterial, enfermedad coronaria, valvulopatías y miocardiopatías. La hipertensión arterial es la primera causa de insuficiencia cardíaca en Chile y se expresa principalmente a través de hipertrofia ventricular izquierda y disfunción diastólica. La enfermedad coronaria genera insuficiencia cardíaca por medio de infarto al miocardio y la isquemia miocárdica sostenida (tejido hibernado, para evitar el compromiso ventricular deben controlarse rigurosamente los factores de riesgo de enfermedad coronaria. En caso de presentarse una obstrucción coronaria aguda se debe reestablecer el flujo coronario a la brevedad para disminuir la necrosis de miocitos. Actualmente las valvulopatías están siendo intervenidas cada vez más precozmente con el fin de evitar la remodelación ventricular patológica irreversible. En relación a las miocardiopatías se debe enfatizar en la necesidad de una detección precoz de la toxicidad por drogas antineoplásicas (ej antraciclinas, del mismo modo debemos preocuparnos de factores emergentes que conducen a insuficiencia cardíaca, ejemplo obesidad.

  14. In Vitro-In Vivo Predictive Dissolution-Permeation-Absorption Dynamics of Highly Permeable Drug Extended-Release Tablets via Drug Dissolution/Absorption Simulating System and pH Alteration.

    Science.gov (United States)

    Li, Zi-Qiang; Tian, Shuang; Gu, Hui; Wu, Zeng-Guang; Nyagblordzro, Makafui; Feng, Guo; He, Xin

    2018-05-01

    Each of dissolution and permeation may be a rate-limiting factor in the absorption of oral drug delivery. But the current dissolution test rarely took into consideration of the permeation property. Drug dissolution/absorption simulating system (DDASS) valuably gave an insight into the combination of drug dissolution and permeation processes happening in human gastrointestinal tract. The simulated gastric/intestinal fluid of DDASS was improved in this study to realize the influence of dynamic pH change on the complete oral dosage form. To assess the effectiveness of DDASS, six high-permeability drugs were chosen as model drugs, including theophylline (pK a1  = 3.50, pK a2  = 8.60), diclofenac (pK a  = 4.15), isosorbide 5-mononitrate (pK a  = 7.00), sinomenine (pK a  = 7.98), alfuzosin (pK a  = 8.13), and metoprolol (pK a  = 9.70). A general elution and permeation relationship of their commercially available extended-release tablets was assessed as well as the relationship between the cumulative permeation and the apparent permeability. The correlations between DDASS elution and USP apparatus 2 (USP2) dissolution and also between DDASS permeation and beagle dog absorption were developed to estimate the predictability of DDASS. As a result, the common elution-dissolution relationship was established regardless of some variance in the characteristic behavior between DDASS and USP2 for drugs dependent on the pH for dissolution. Level A in vitro-in vivo correlation between DDASS permeation and dog absorption was developed for drugs with different pKa. The improved DDASS will be a promising tool to provide a screening method on the predictive dissolution-permeation-absorption dynamics of solid drug dosage forms in the early-phase formulation development.

  15. Recuperación del epitelio germinal masculino de ratones tratados con dosis única de Busulfán

    Directory of Open Access Journals (Sweden)

    Luis Guzmán

    2013-05-01

    Full Text Available Busulfán es un agente alquilante bifuncional tipo-éster, que interfiere con la replicación del ADN. Dosis elevadas de este compuesto son aplicadas antes de los transplantes de médula ósea y de células germinales, sin embargo no han sido cuantificados el daño ni la recuperación del sistema reproductor. Para cuantificar la recuperación del efecto en la espermatogénesis, se usaron ratones de la cepa Balb C, a los que se les inyectó Busulfán intraperitonealmente, 40 mg/kg de peso corporal, y se evaluó el peso testicular y la concentración espermática en cola de epidídimo, a los 30, 54 y 72 días y se realizaron cortes histológicos de testículo. Los resultados fueron analizados con la prueba U Mann-Whitney p>0.05. A los 30 días el peso testicular, la concentración espermática y el diámetro de los túbulos seminíferos presentaron una drástica reducción del 77,8%, 97,9% y 34,3% respectivamente, comparados con el grupo control. A los 54 días, el peso testicular y el diámetro testicular muestran una recuperación del 70%. A los 72 días, la recuperación es completa en los parámetros evaluados. Por lo tanto, Busulfán aplicado en una sola dosis afecta significativamente la espermatogénesis en el ratón y se logra la recuperación completa en dos ciclos espermáticos.

  16. The highest velocity and the shortest duration permitting attainment of VO2max during running

    Directory of Open Access Journals (Sweden)

    Tiago Turnes

    2015-02-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2015v17n2p226   The severe-intensity domain has important applications for the prescription of running training and the elaboration of experimental designs. The objectives of this study were: 1 to investigate the validity of a previously proposed model to estimate the shortest exercise duration (TLOW and the highest velocity (VHIGH at which VO2max is reached during running, and 2 to evaluate the effects of aerobic training status on these variables. Eight runners and eight physically active subjects performed several treadmill running exercise tests to fatigue in order to mathematically estimate and to experimentally determine TLOW and VHIGH. The relationship between the time to achieve VO2max and time to exhaustion (Tlim was used to estimate TLOW. VHIGH was estimated using the critical velocity model. VHIGH was assumed to be the highest velocity at which VO2 was equal to or higher than the average VO2max minus one standard deviation. TLOW was defined as Tlim associated with VHIGH. Runners presented better aerobic fitness and higher VHIGH (22.2 ± 1.9 km.h-1 than active subjects (20.0 ± 2.1 km.h-1. However, TLOW did not differ between groups (runners: 101 ± 39 s; active subjects: 100 ± 35 s. TLOW and VHIGH were not well estimated by the model proposed, with high coefficients of variation (> 6% and a low correlation coefficient (r<0.70, a fact reducing the validity of the model. It was concluded that aerobic training status positively affected only VHIGH. Furthermore, the model proposed presented low validity to estimate the upper boundary of the severe-intensity domain (i.e., VHIGH, irrespective of the subjects’ training status.

  17. Correlation of Color Doppler with Multidetector CT Angiography Findings in Carotid Artery Stenosis

    Directory of Open Access Journals (Sweden)

    Živorad N. Savic

    2010-01-01

    Full Text Available The aim of this paper was to examine the correlation between the Color Doppler ultrasound (CD-US and multidetector CT angiography (MDCTA diagnostic methods, and to define the degree and extent of stenosis in patients with internal carotid artery stenosis. This was a cross-sectional study with a consecutive series of patients. All US examinations were always carried out by the same physician-angiologist, while all CT examinations were always carried out by the same physician-radiologist. Both worked independently from each other. The stenosis area was measured at the narrowest point by NASCET criteria for US/CT. Peak systolic velocity (PSV over 210 cm/sec and end diastolic velocity (EDV over 110 cm/sec criteria were applied for stenoses with lumen narrowed over 70%, while PSV under 130 cm/sec and EDV under 100 cm/sec criteria were applied for those with lumen narrowed under 70%. A total of 124 carotid arteries were observed; namely, 89 narrowed and 68 surgically treated. All patients were reviewed by US and then by MDCTA; patients with 70–99% stenosis underwent surgery. The correlation coefficient between stenosis degree measured by US and MDCTA was 0.922; p 0.05. The US and CT matching level for stenoses from 70 to 99% was very high (κ = 0.778, p < 0.01. In conclusion, there is a highly significant statistical correlation among both diagnostic methods when measuring stenosis degree and extent. US is more dependent on the physician, while MDCTA is more objective and independent from the physician. We think it would be appropriate to undertake an MDCTA exam for those patients who are candidates for carotid endarterectomy.

  18. Optimization of Experimental Conditions of the Pulsed Current GTAW Parameters for Mechanical Properties of SDSS UNS S32760 Welds Based on the Taguchi Design Method

    Science.gov (United States)

    Yousefieh, M.; Shamanian, M.; Saatchi, A.

    2012-09-01

    Taguchi design method with L9 orthogonal array was implemented to optimize the pulsed current gas tungsten arc welding parameters for the hardness and the toughness of super duplex stainless steel (SDSS, UNS S32760) welds. In this regard, the hardness and the toughness were considered as performance characteristics. Pulse current, background current, % on time, and pulse frequency were chosen as main parameters. Each parameter was varied at three different levels. As a result of pooled analysis of variance, the pulse current is found to be the most significant factor for both the hardness and the toughness of SDSS welds by percentage contribution of 71.81 for hardness and 78.18 for toughness. The % on time (21.99%) and the background current (17.81%) had also the next most significant effect on the hardness and the toughness, respectively. The optimum conditions within the selected parameter values for hardness were found as the first level of pulse current (100 A), third level of background current (70 A), first level of % on time (40%), and first level of pulse frequency (1 Hz), while they were found as the second level of pulse current (120 A), second level of background current (60 A), second level of % on time (60%), and third level of pulse frequency (5 Hz) for toughness. The Taguchi method was found to be a promising tool to obtain the optimum conditions for such studies. Finally, in order to verify experimental results, confirmation tests were carried out at optimum working conditions. Under these conditions, there were good agreements between the predicted and the experimental results for the both hardness and toughness.

  19. EXO70C2 is a key regulatory factor for optimal tip growth of pollen

    KAUST Repository

    Synek, Lukas

    2017-03-30

    The exocyst, an eukaryotic tethering complex, co-regulates targeted exocytosis as an effector of small GTPases in polarized cell growth. In land plants, several exocyst subunits are encoded by double or triple paralogs, culminating in tens of EXO70 paralogs. Out of 23 Arabidopsis EXO70 isoforms, we analyzed seven isoforms expressed in pollen. Genetic and microscopic analyses of single mutants in EXO70A2, C1, C2, F1, H3, H5, and H6 genes revealed that only a loss-of-function EXO70C2 allele resulted in a significant male-specific transmission defect (segregation 40%:51%:9%) due to aberrant pollen tube growth. Mutant pollen tubes grown in vitro exhibited enhanced growth rate and a decreased thickness of the tip cell wall, causing tip bursts. However, exo70C2 pollen tubes could frequently recover and restart their speedy elongation, resulting in a repetitive stop-and-go growth dynamics. A pollen-specific depletion of the closest paralog, EXO70C1, using ami-RNA in the exo70C2 mutant background resulted in a complete pollen-specific transmission defect, suggesting redundant functions of EXO70C1 and EXO70C2. Both EXO70C1 and EXO70C2, GFP-tagged and expressed under their native promoters, localized in the cytoplasm of pollen grains, pollen tubes, and also root trichoblast cells. Expression of EXO70C2-GFP complemented aberrant growth of exo70C2 pollen tubes. The absent EXO70C2 interactions with core exocyst subunits in the yeast two-hybrid assay, cytoplasmic localization, and genetic effect suggest an unconventional EXO70 function possibly as a regulator of exocytosis outside the exocyst complex. In conclusion, EXO70C2 is a novel factor contributing to the regulation of optimal tip growth of Arabidopsis pollen tubes.

  20. Engineered Humicola insolens cutinase for efficient cellulose acetate deacetylation.

    Science.gov (United States)

    Shirke, Abhijit N; Butterfoss, Glenn L; Saikia, Rakhi; Basu, Aditya; de Maria, Leonardo; Svendsen, Allan; Gross, Richard A

    2017-08-01

    Cutinases comprise a family of esterases with broad hydrolytic activity for chain and pendant ester groups. This work aimed to identify and improve an efficient cutinase for cellulose acetate (CA) deacetylation. The development of a mild method for CA fiber surface deacetylation will result in improved surface hydrophilicity and reactivity while, when combined with cellulases, a route to the full recycling of CA to acetate and glucose. In this study, the comparative CA deacetylation activity of four homologous wild-type (wt) fungal cutinases from Aspergillus oryzae (AoC), Thiellavia terrestris (TtC), Fusarium solani (FsC), and Humicola insolens (HiC) was determined by analysis of CA deacetylation kinetics. wt-HiC had the highest catalytic efficiency (≈32 [cm 2 L -1 ] -1 h -1 ). Comparison of wt-cutinase catalytic constants revealed that differences in catalytic efficiency are primarily due to corresponding variations in corresponding substrate binding constants. Docking studies with model tetrameric substrates also revealed structural origins for differential substrate binding amongst these cutinases. Comparative docking studies of HiC point mutations led to the identification of two important rationales for engineering cutinases for CA deacetylation: (i) create a tight but not too closed binding groove, (ii) allow for hydrogen bonding in the extended region around the active site. Rationally designed HiC with amino acid substitutions I36S, predicted to hydrogen bond to CA, combined with F70A, predicted to remove steric constraints, showed a two-fold improvement in catalytic efficiency. Continued cutinase optimization guided by a detailed understanding of structure-activity relationships, as demonstrated here, will be an important tool to developing practical cutinases for commercial green chemistry technologies. Copyright © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Study of Stroke Incidence in the Aseer Region, Southwestern Saudi Arabia.

    Science.gov (United States)

    Alhazzani, Adel A; Mahfouz, Ahmed A; Abolyazid, Ahmed Y; Awadalla, Nabil J; Aftab, Razia; Faraheen, Aesha; Khalil, Shamsun Nahar

    2018-01-26

    Recent data regarding first-stroke incidence in Saudi Arabia in general and in the Aseer region in particular are scarce and even lacking. The aim of this work was to study the first-time stroke incidence in the Aseer region, southwestern Saudi Arabia. All first-stroke patients admitted to all hospitals in the Aseer region over a one-year period (January through December 2016) were included. Stroke patients outside the Aseer region were excluded from the study. The incidence per 100,000 patients and the concomitant 95% CI (Confidence Intervals) were computed. The present study included 1249 first-time stroke patients and calculated an overall minimal incidence rate of hospitalized first-time stroke of 57.64 per 100,000 persons per year (95% CI: 57.57-57.70). A steady increase was noticed depending on the patients' age, reaching a figure of 851.81 (95% CI: 849.2-854.5) for those patients aged 70 years and more. Overall, the incidence rate for females (48.14; 95% CI: 48.04-48.24) was lower compared to males (65.52; 95% CI: 65.1-66.0). Taking into consideration the expected rise of the elderly because of the prominent medical services provided by the Saudi government, leading to a subsequent change in the horizontal and vertical age distribution structure of the population, an increase in the number of stroke patients is expected. It is suggested to establish a nationwide stroke surveillance system in the Kingdom, with the objective to report, analyze, and maintain an updated overview of the stroke status in Saudi Arabia.

  2. The role of ontogeny in physiological tolerance: decreasing hydrostatic pressure tolerance with development in the northern stone crab Lithodes maja.

    Science.gov (United States)

    Munro, Catriona; Morris, James P; Brown, Alastair; Hauton, Chris; Thatje, Sven

    2015-06-22

    Extant deep-sea invertebrate fauna represent both ancient and recent invasions from shallow-water habitats. Hydrostatic pressure may present a significant physiological challenge to organisms seeking to colonize deeper waters or migrate ontogenetically. Pressure may be a key factor contributing to bottlenecks in the radiation of taxa and potentially drive speciation. Here, we assess shifts in the tolerance of hydrostatic pressure through early ontogeny of the northern stone crab Lithodes maja, which occupies a depth range of 4-790 m in the North Atlantic. The zoea I, megalopa and crab I stages were exposed to hydrostatic pressures up to 30.0 MPa (equivalent of 3000 m depth), and the relative fold change of genes putatively coding for the N-methyl-D-aspartate receptor-regulated protein 1 (narg gene), two heat-shock protein 70 kDa (HSP70) isoforms and mitochondrial Citrate Synthase (CS gene) were measured. This study finds a significant increase in the relative expression of the CS and hsp70a genes with increased hydrostatic pressure in the zoea I stage, and an increase in the relative expression of all genes with increased hydrostatic pressure in the megalopa and crab I stages. Transcriptional responses are corroborated by patterns in respiratory rates in response to hydrostatic pressure in all stages. These results suggest a decrease in the acute high-pressure tolerance limit as ontogeny advances, as reflected by a shift in the hydrostatic pressure at which significant differences are observed. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  3. Variables transdiagnósticas predictoras de los problemas emocionales y afectivos en una muestra colombiana

    Directory of Open Access Journals (Sweden)

    Ronald Alberto Toro Tobar

    2018-05-01

    Full Text Available El modelo transdiagnóstico se basa en la evaluación y tratamiento de las variables etiológicas y mantenedoras de los trastornos mentales. El objetivo fue establecer la relación entre las variables transdiagnósticas perfeccionismo, rumiación, afecto positivo y negativo, sensitividad ansiosa e intolerancia a la incertidumbre, con estrés, ansiedad y depresión. Participaron 333 adultos convocados mediante muestreo no probabilístico incidental, cuyas edades oscilaron entre los 18 y los 70 años (M = 28, DE = 8,70, un 37,46% hombres y un 62,54% mujeres, solteros (66,27%, universitarios (65,57% principalmente. Se llevó a cabo un estudio no experimental predictivo transversal. En los resultados se encontraron correlaciones significativas entre ansiedad y depresión, además de intolerancia a la incertidumbre y perfeccionismo, y depresión con afecto positivo-negativo y perfeccionismo. En estrés se obtuvieron correlaciones significativas con rumiación y estilo emocional. El modelo predictivo resaltó las variables intolerancia a la incertidumbre, sensitividad ansiosa y afecto positivo y negativo para predecir ansiedad (r2 = 0,43, depresión (r2 = 0,37 y estrés (r2 = 0,17. Se concluyó que los resultados aportan evidencias a favor del modelo transdiagnóstico para la ansiedad y depresión y en menor medida para estrés.

  4. Carcinoma basocelular de los párpados Basocelular eyelid carcinoma

    Directory of Open Access Journals (Sweden)

    Clara G. Gómez Cabrera

    2001-12-01

    Full Text Available Se realizó un análisis de tipo retrospectivo de 39 pacientes operados, con diagnóstico histológico de carcinoma basocelular de los párpados en el período comprendido entre febrero de 1995 y diciembre de 1999. Se excluyeron los pacientes operados sin clasificación TNM. Este tumor se localizó en el párpado inferior de 22 pacientes (56,4 %. La variedad noduloulcerativa estuvo presente en 27 casos (69,2 %. 34 pacientes se encontraban en los estadios T1 y T2, 4 en el estadio T3 y solo 1 en T4. El grupo de mayor incidencia fue el de pacientes entre 50 y 70 años de edad. No hubo diferencias en cuanto al sexo. El párpado inferior constituyó la localización anatómica prevaleciente. La variedad clínica noduloulcerativa predominó, así como los estadios T1 y T2.A retrospective analysis of 39 patients that were operated on with histological diagnosis of basocelular eyelid carcinoma from February, 1995, to December, 1999, was made. Those patients who underwent surgery without TNM classification were excluded. This tumor was localized in the lower eyelid of 22 patients (56.4 %. The nodular ulcerative variety was present in 27 cases (69.2 %. 34 patients were in stages T1 and T2, 4 in T3 and only 1 in T4. The group of highest incidence was that of the patients aged 50-70. There were no differences as regards sex. The lower eyelid was the prevailing anatomic localization. The clinical nodular ulcerative variety predominated, as well as stages T1 and T2.

  5. Moessbauer spectroscopic determination of magnetic moments of Fe3+ and Co2+ in substituted barium hexaferrite, Ba(Co,Ti)xFe(12-2x)O19

    International Nuclear Information System (INIS)

    Williams, J.M.; Adetunji, J.; Gregori, M.

    2000-01-01

    We report the distribution of magnetic moments of Fe 3+ and Co 2+ in Co 2+ -, Ti 4+ -substituted M-type barium hexaferrite, Ba(Co,Ti) x Fe (12-2x) O 19 , as a function of doping rate, x. The substitution, x, for iron has been varied with x=0, 0.25, 0.50, 0.70 and 0.85. The magnetic moments of Fe 3+ and Co 2+ were calculated from the combined results of Moessbauer measurements for Fe 3+ ions in the sublattices and neutron diffraction data for the total moments of Fe 3+ and Co 2+ . A comparison of the signs of the magnetic moments of Fe 3+ and Co 2+ ions enabled us to attribute spin directions of the Co 2+ ions in the sublattices of the substituted ferrite samples. The spin directions of Co 2+ are opposite to those of Fe 3+ in the 4f 2 and 2b sublattices. They are reversed from the original directions in the 4f 1 and 12K sublattices when the value of x≥0.70. A quantitative analysis shows that Co 2+ and Ti 4+ ions are preferably substituted into 4f 2 and 12K sublattices, respectively. In addition, while the hyperfine field of Fe 3+ in the 2b sublattice gives rise to the 2b-4f 2 interaction it is the partially substituted Co 2+ ions in the 4f 1 and 12K sublattices that contribute to the near neighbour 2a-4f 1 and 2b-12K types of interaction

  6. μSR-investigation of high-Tc superconductors at the LNP JINR phasotron

    International Nuclear Information System (INIS)

    Bezhitadze, D.T.; Borovinskaya, I.P.; Burianek, J.

    1989-01-01

    High-T c superconductors La 2-x Sr x CuO 4 (x=0+0.25), Ho(Er)Ba 2 Cu 3 O 7-y and Bi-Sr-Ca-Cu-O (the main phase 2212 with a small admixture of the 2223-phase) were investigated in the zero and 100+400 Oe transverse external magnetic fields in the temperature interval 4.2+300 K. The magnetic ordering for the La 2-x Sr x CuO 4 samples with x=0.00 and x=0.01 occurs below T N ∝250 K and T N ∝170 K respectively. A considerable increase in the distribution width of the magnetic field on the muon with an increase in the Sr-content indicates an enhancement of the Cu 2+ magnetic moment deviation from the magnetic ordering axis. The results of the analysis of the μSR spectra indicate the formation of the spin glass state in the La 1.93 Sr 0.07 CuO 4 sample. In contrast to the behaviour of the HoBa 2 Cu 3 O 7-y ceramic the magnetic ordering of the Er-atoms in the ErBa 2 Cu 3 O 7-y sample is not observed in the conparable temperature interval. Our data has also allowed the magnetic field penetration depth λ perpendicular (0) to be determined: 3200±70 A for La 1.9 Sr 0.1 CuO 4 , 2420±60 A for La 1.85 Sr 0.15 CuO 4 , 2000±50 A for Bi-Sr-Ca-Cu-O (phase 2212), 1600±50 A for ErBa 2 Cu 3 O 7-y . 20 refs.; 8 figs

  7. PENGEMBANGAN PEMBELAJARAN IPA SMK DENGAN MODEL KONTEKSTUAL BERBASIS PROYEK UNTUK MENINGKATKAN HASIL BELAJAR DAN KETERAMPILAN PROSES SAINS SISWA

    Directory of Open Access Journals (Sweden)

    M.N. Hayati

    2013-04-01

    Full Text Available Penelitian ini adalah penelitian pengembangan pada pembelajaran IPA SMK dengan model kontekstual berbasis proyek untuk meningkatkan hasil belajar dan KPS siswa. Perangkat pembelajaran yang dikembangkan valid dengan rata-rata 3,68, dan efektif karena telah mampu memenuhi indikator yang diharapkan, yaitu: terdapat peningkatan KPS dengan skor rata-rata 72,85 dan ketuntasan klasikal 80,6% (29 dari 36 siswa telah tuntas; terdapat peningkatan hasil belajar kognitif siswa, yaitu rata-rata meningkat dari 58,33 menjadi 81,39 dan ketuntasan klasikal 92% (33 dari 36 siswa telah tuntas; rata-rata hasil belajar afektif dan psikomotorik siswa juga mencapai indikator keberhasilan yang ditetapkan, yaitu ≥ 70; serta sebanyak 91,18% (31 dari 34 siswa memberikan respon baik terhadap pembelajaran kontekstual berbasis proyek. This research is though development of science learning at vocational school using contextual model based on project to improve the learning result and science process skill students. The teaching and learning advise used in teaching “ways in handling waste” topic using contextual model based on project valid with average 3,68, effective because is able to complete the indicator, there is an increase of Science Process Skill with an average score of 72,85 and 80,6% completeness classical or 29 among 36 students have completed. There is an increase students’ cognitive learning outcomes, the average increased from 58,33 to 81,39 and 92 % classical completeness, or 33 among 36 students have completed. The average of affective and psychomotor learning outcomes students’ achieve well defined indicators of success, were ≥ 70. A total of 91,18% or 31 among 34 students responded well to the project based learning.

  8. The pestivirus N terminal protease N(pro redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro..

    Directory of Open Access Journals (Sweden)

    Matthew Jefferson

    Full Text Available The N-terminal protease of pestiviruses, N(pro is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of interferon production. An important question remains the role of N(pro in the inhibition of apoptosis. In this study, apoptotic signals induced by staurosporine, interferon, double stranded RNA, sodium arsenate and hydrogen peroxide were inhibited by expression of wild type N(pro, but not by mutant protein N(pro C112R, which we show is less efficient at promoting degradation of IRF3, and led to the conclusion that N(pro inhibits the stress-induced intrinsic mitochondrial pathway through inhibition of IRF3-dependent Bax activation. Both expression of N(pro and infection with Bovine Viral Diarrhea Virus (BVDV prevented Bax redistribution and mitochondrial fragmentation. Given the role played by signaling platforms during IRF3 activation, we have studied the subcellular distribution of N(pro and we show that, in common with many other viral proteins, N(pro targets mitochondria to inhibit apoptosis in response to cell stress. N(pro itself not only relocated to mitochondria but in addition, both N(pro and IRF3 associated with peroxisomes, with over 85% of N(pro puncta co-distributing with PMP70, a marker for peroxisomes. In addition, peroxisomes containing N(pro and IRF3 associated with ubiquitin. IRF3 was degraded, whereas N(pro accumulated in response to cell stress. These results implicate mitochondria and peroxisomes as new sites for IRF3 regulation by N(pro, and highlight the role of these organelles in the anti-viral pathway.

  9. The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.).

    Science.gov (United States)

    Jefferson, Matthew; Whelband, Matthew; Mohorianu, Irina; Powell, Penny P

    2014-01-01

    The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of interferon production. An important question remains the role of N(pro) in the inhibition of apoptosis. In this study, apoptotic signals induced by staurosporine, interferon, double stranded RNA, sodium arsenate and hydrogen peroxide were inhibited by expression of wild type N(pro), but not by mutant protein N(pro) C112R, which we show is less efficient at promoting degradation of IRF3, and led to the conclusion that N(pro) inhibits the stress-induced intrinsic mitochondrial pathway through inhibition of IRF3-dependent Bax activation. Both expression of N(pro) and infection with Bovine Viral Diarrhea Virus (BVDV) prevented Bax redistribution and mitochondrial fragmentation. Given the role played by signaling platforms during IRF3 activation, we have studied the subcellular distribution of N(pro) and we show that, in common with many other viral proteins, N(pro) targets mitochondria to inhibit apoptosis in response to cell stress. N(pro) itself not only relocated to mitochondria but in addition, both N(pro) and IRF3 associated with peroxisomes, with over 85% of N(pro) puncta co-distributing with PMP70, a marker for peroxisomes. In addition, peroxisomes containing N(pro) and IRF3 associated with ubiquitin. IRF3 was degraded, whereas N(pro) accumulated in response to cell stress. These results implicate mitochondria and peroxisomes as new sites for IRF3 regulation by N(pro), and highlight the role of these organelles in the anti-viral pathway.

  10. Efeito da deferoxamina na isquemia e reperfusão do fígado remanescente após ressecção hepática parcial

    Directory of Open Access Journals (Sweden)

    Brisotti João Luiz

    2000-01-01

    Full Text Available Particularmente, a utilização de vários tipos de drogas que diminuem os efeitos deletérios do binômio isquemia-reperfusão, tem tornado-se foco de vários estudos experimentais visando possíveis aplicações clínicas. O objetivo do presente estudo foi avaliar os efeitos da deferoxamina na isquemia e reperfusão sobre o fígado remanescente após ressecção hepática parcial a 70%, avaliando-se váriáveis bioquímicas do sangue: aspartato aminotransferase e alanina aminotransferase;.A amostra de 34 ratos foi dividida em grupos: Grupo HP (n = 8 - submetidos a hepatectomia parcial (HP a 70%; Grupo HPD (n = 4 - submetidos a administração de deferoxamina (40 mg/kg e HP a 70%; Grupo HPI (n = 7 - hepatectomizados (HP a 70% e submetidos a isquemia (40 minutos; Grupo HPID (n = 7 - semelhante ao anterior, porém recebendo previamente deferoxamina; Grupo C (n = 8 - controle, submetido a operação simulada para HP a 70%. A análise estatística entre os diversos grupos foi feita pelos testes de Kruskal - Wallis e de Mann - Whitney, com nível de significância de 5%. Portanto, houve aumento significativo das aminotransferases nos animais submetidos a hepatectomia e a isquemia. Esse aumento foi inibido pela deferoxamina.

  11. Regenerative medicine in the treatment of gastro-esophageal reflux disease and laryngo-pharyngeal reflux. From research to cure.

    Science.gov (United States)

    Aragona, S E; Mereghetti, G; Bianchetti, M; Mangiavillano, B; Zurlo, T; Lotti, J; La Mantia, I; França, K; Lotti, T

    We present our observational study on 40 patients treated with the medical device containing sodium hyaluronic acid and magnesium alginate, performing a lubricating and hydrating action. This device is in the form of a gel, with topical action to contrast gastroesophageal reflux and to exert a mechanical role of protection of the mucosal tissues (mouth-pharyngo-esophageal mucosa and gastric mucose.). Forty patients were recruited aged between 22- and 72-years-old with painful dyspeptic Gastro Esophageal Reflux Disease (GERD) symptomatology in acute or in clinical phase (25 patients) and with pharyngolaryngo- tracheal symptomatology (15 patients). Patients were divided into two clinical groups: Group A was treated with the medical device, while Group B with conventional treatments without the medical device. Subjects of both groups were also treated with proton pump inhibitors (PPIs). Follow-up was at 10, 20 and 30 days and patients were evaluated for reduction of their subjective symptoms, reduction of symptomatic and occasional therapies, reduction of inflammatory process or disappearance of epithelial lesions of the examined mucosa, healing process. The reduction of subjective symptoms was observed at 10 days in the patient with food bolus (disappearance after 5 days) and in patients with a reduction of 70%. A relevant reduction in the use of symptomatic drugs was noted. Our data are relevant considering symptom relief (heartburn, reflux and dyspepsia). New scenarios for the treatment of inflammatory diseases of the digestive and respiratory tract mucosa are at the horizon. Interdisciplinary translational research brings to the development of novel medical devices (as the one described in this study) with a high safety profile, and extremely active on the inflammation-repair-regeneration complex of different tissues and organs.

  12. Observations of high-n transitions in the spectra of near-neon-like copper ions from laser-produced plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Fournier, K.B. [Lawrence Livermore National Laboratory, Livermore, CA (United States); Faenov, A.Ya.; Pikuz, T.A.; Skobelev, I.Yu. [Multicharged Ions Spectra Data Center of VNIIFTRI, Moscow (Russian Federation); Flora, F.; Bollanti, S.; Lazzaro, P.Di.; Murra, D. [ENEA, Dipartimento Innovazione, Settore Fisica Applicata, Frascati, Rome (Italy); Grilli, A. [INFN Frascati, Rome (Italy); Reale, A.; Reale, L.; Tomassetti, G.; Ritucci, A. [Dipartimento di Fisica e INFM, INFN g.c. LNGS, Universita dell' Aquila, L' Aquila (Italy); Bellucci, I.; Martellucci, S.; Petrocelli, G. [INFM, Dipartimento di Scienze e Tecnologie Fisiche ed Energetiche, Universita di Roma Tor Vergata, Rome (Italy)

    2002-08-14

    Spectra in the 7.50-8.70 A range from highly charged copper ions are analysed, and line identifications are made for the Na-, Ne-, F- and O-like charge states. The spectra are recorded with a spherically bent crystal spectrometer using either a mica or quartz crystal for moderate ({lambda}/{delta}{lambda}=3000) and high ({lambda}/{delta}{lambda}=8000) energy resolution, respectively. The plasmas from which the spectra are emitted are formed with either a Nd:glass (15 ns pulse) or a XeCl (12 ns pulse) laser. Systematic variations in the observed spectra with pulse energy are studied. Using different laser energies, and defocusing of the laser to reduce the intensity, we create plasmas with different ionization state distributions, which allows us to deconvolve blended lines from different copper ions. Line identifications are made based on relativistic atomic structure calculations that account for configuration interaction in level energies and transition rates. We use full kinetics simulations of ion emissivities, not just calculations of theoretical transition energies, to identify the strong and weak lines in crowded spectral regions. We identify 2p-nl transitions for Ne-like Cu{sup 19+} for 4{<=}n{<=}8 and 2s-np transitions for 4{<=}n{<=}6. We offer the first identification of high-n (n{<=}8) Na-like satellites to Ne-like Rydberg resonance lines. The first and second ionization energies for Cu{sup 19+} are found, at 1689.02 and 1709.16 eV, respectively, based on our observations. (author)

  13. Estudio del crecimiento de Prioria copaifera (Caesalpinaceae mediante técnicas dendrocronológicas

    Directory of Open Access Journals (Sweden)

    Jorge Andrés Giraldo Jiménez

    2011-12-01

    Full Text Available El cativo (Prioria copaifera G. forma bosques dominados por la especie llamados cativales. Durante más de 70 años el cativo ha sido la base principal de la industria maderera en el Darién colombiano, siendo, por su alta productividad y dominancia uno de los bosques tropicales más fáciles de ordenar sosteniblemente. El propósito de esta investigación es modelar el crecimiento del diámetro y el volumen del cativo en función de la edad así como las tasas instantáneas, medias y relativas, empleando anillos de crecimiento. La anualidad de los anillos se demostró usando el efecto de las bombas nucleares y mediante cofechado. Con base en los anillos de crecimiento radiales se modelo el crecimiento del diámetro y del volumen. Esta especie alcanza 40cm de diámetro en 90 años y presenta crecimiento medio de 0.31cm/año. El lapso vital de la especie es de aproximadamente 614 años. El incremento corriente anual máximo del volumen a los 90 años es 0.033m3/año, e iguala al incremento medio a los 145 años con 0.018m3/año. La tasa media de crecimiento absoluta es 0.021m3/año. Los resultados aquí obtenidos sirven como base técnica para el manejo sostenible de los cativales.

  14. Ion beam modification of surfaces for biomedical applications

    International Nuclear Information System (INIS)

    Sommerfeld, Jana

    2014-01-01

    Human life expectancy increased significantly within the last century. Hence, medical care must ever be improved. Optimizing artificial replacements such as hip joints or stents etc. is of special interest. For this purpose, new materials are constantly developed or known ones modified. This work focused on the possibility to change the chemistry and topography of biomedically relevant materials such as diamond-like carbon (DLC) and titanium dioxide (TiO 2 ) by means of ion beam irradiation. Mass-separated ion beam deposition was used in order to synthesize DLC layers with a high sp 3 content (> 70%), a sufficiently smooth surface (RMS<1 nm) and a manageable film thickness (50 nm). The chemistry of the DLC layers was changed by ion beam doping with different ion species (Ag,Ti) and concentrations. Additionally, the surface topography of silicon and titanium dioxide was altered by ion beam irradiation under non-perpendicular angle of incidence. The created periodic wave structures (so-called ripples) were characterized and their dependency on the ion energy was investigated. Moreover, ripples on silicon were covered with a thin DLC layer in order to create DLC ripples. The biocompatibility of all samples was investigated by adsorption experiments. For this purpose, human plasma fibrinogen (HPF) was used due to its ambiphilic character, which allows the protein to assume different conformations on materials with different hydrophilicities. Moreover, HPF is a crucial factor in the blood coagulation process. This work comes to the conclusion that the interaction of both, the surface chemistry and topography, has a strong influence on the adsorption behavior of HPF and thus the biocompatibility of a material. Both factors can be specifically tuned by means of ion beam irradiation.

  15. Mass Spectrometry for Large Undergraduate Laboratory Sections

    Science.gov (United States)

    Illies, A.; Shevlin, P. B.; Childers, G.; Peschke, M.; Tsai, J.

    1995-08-01

    min. Under these conditions each analysis takes the student about 10 min and two students are scheduled per 20 min block. Since the instrument is under computer control, students operate the computer during the run. As the peaks appear on the mass chromatogram, their mass spectra are obtained and the student decides which corresponds to product and evaluates product purity and the structure of impurities. There is ample time to display all spectra, conduct library searches, and print data. This relatively simple laboratory exercise has the advantage of allowing each student to carry out an analysis on his or her own product. The fact that a brominated product is obtained introduces a discussion of isotopic patterns in mass spectrometry. The experiment is scheduled to coincide with the lecture discussion of spectroscopic structure determination and after SN2 reactions have been covered. One of our mass spectrometer satellite data stations is interfaced with a "3-gun" projector in a large lecture hall allowing the display of actual mass spectra from our instrument to lecture sections. AcknowlegementThis work was partially supported by a grant, DUE9350846, from the National Science Foundation Division of Undergraduate Education Instrumentation and Laboratory Improvement Program. Literature Cited Brush, R. C.; Rice, G. W. J. Chem. Educ. 1994, 71, A293-A294. Asleson, G. L.; Doig, M. T.; Heldrich, F. J. J. Chem. Educ. 1993, 70, A290. Novak, M.; Heinrich, J. J. Chem. Educ. 1993, 70, A150. (b) Novak, M.; Heinrich, J.; Martin, K. A. J. Chem. Educ. 1993, 70, A103-104. Harman, C. S.; Myers, D. P.; Rittle, K. J. J. Chem. Educ. 1991, 68, 438-42. Mabbott, G. A. J. Chem. Educ. 1990, 67, 441-5. Hill, D. W.; McSharry, B. T.; Trzupek. J. Chem. Educ. 1988, 65, 907-10. Williamson, K. L. Macroscale and Microscale Organic Experiments, 2nd ed.; D. C. Heath: Lexington, MA, 1994; pp 247-51.

  16. Dataciones radiometricas (14C y K/Ar del Teide y el Rift noroeste, Tenerife, Islas Canarias

    Directory of Open Access Journals (Sweden)

    Hansen, A.

    2003-08-01

    volcán Pico Viejo (17.570 f 150 a BP, los centros eruptivos adventicios fonolíticos de la base del Teide (Mña. Abejera centro alto, 5.170 f 110 a BP; Mña. Abejera centro bajo, 4.790 f 70 a BP; Mña. de La Angostura inicial, 2.420 f 70 a BP; Mña. de La Angostura, 2.010 f 60 a BP y Roques Blancos, 1.790 f 60 a BP, y en el Rift NO (Mña. Chío, 3.620 f 70 a BP. Aunque la actividad volcánica de los últimos 20 Ka incluye al menos 7 erupciones fonolíticas de gran volumen de centros eruptivos situados en la cara norte del Teide, supuestamente muy inestable, esto no parece haber generado respuesta alguna del sistema volcánico. Más bien ha contribuido a asegurar la estabilidad estructural del conjunto, al aumentar y reforzar la base del estratovolcán. Por el contrario, la ocurrencia de estas erupciones y las del Rift NO imponen un elevado riesgo por flujo de coladas en el norte y oeste de Tenerife, zona ahora densamente poblada y que ha sido casi totalmente recubierta con lavas en los últimos 20.000 años.

  17. Efectividad de distintas terapias físicas en el tratamiento conservador de la fascitis plantar. Revisión sistemática

    Directory of Open Access Journals (Sweden)

    Ana María Díaz López

    2014-01-01

    Full Text Available Fundamentos: La fascitis plantar es la afección más frecuente de dolor no traumático en el tobillo-pie. Se presenta más en mujeres entre los 40-70 años con comienzo progresivo y difuso en planta del pie o tobillo que poco a poco se agudiza impidiendo la marcha. El objetivo de este trabajo es determinar si las distintas terapias físicas utilizadas en el tratamiento conservador de la fascitis plantar de al menos un mes de evolución son efectivas individualmente y/o combinadas entre sí. Métodos: Revisión sistemática en las bases de datos The Cochrane Library Plus, Medline, Lilacs, IBECS, IME, PEDro y Enfispo sin restricción de fecha, en español e inglés. Se incluyeron ensayos clínicos controlados aleatoriamente con personas adultas diagnosticadas de fascitis plantar, estudios de intervención, prospectivos y revisiones sistemáticas. La evaluación de la elegibilidad de los estudios fue desarrollada por dos revisores de manera independiente, estandarizada y no cegada. Para clasificarlos, se utilizó la escala crítica PEDro, formulario de calidad metodológica y una revisión crítica de cada resumen y si esto no fue concluyente evaluación del texto completo. Resultados: Se revisó un total de 32 artículos a texto completo. Las técnicas más empleadas fueron los estiramientos y las ondas de choque, aunque los mejores resultados se obtuvieron combinando varias técnicas. Las ondas de choque fueron efectivas cuando otras técnicas fracasaron. Conclusiones: Las terapias físicas empleadas en los distintos estudios han demostrado ser eficaces aunque en distinta medida ya sea para disminuir el dolor o aliviar los síntomas de la fascitis plantar.

  18. Early Arabidopsis root hair growth stimulation by pathogenic strains of Pseudomonas syringae.

    Science.gov (United States)

    Pecenková, Tamara; Janda, Martin; Ortmannová, Jitka; Hajná, Vladimíra; Stehlíková, Zuzana; Žárský, Viktor

    2017-09-01

    Selected beneficial Pseudomonas spp. strains have the ability to influence root architecture in Arabidopsis thaliana by inhibiting primary root elongation and promoting lateral root and root hair formation. A crucial role for auxin in this long-term (1week), long-distance plant-microbe interaction has been demonstrated. Arabidopsis seedlings were cultivated in vitro on vertical plates and inoculated with pathogenic strains Pseudomonas syringae pv. maculicola (Psm) and P. syringae pv. tomato DC3000 (Pst), as well as Agrobacterium tumefaciens (Atu) and Escherichia coli (Eco). Root hair lengths were measured after 24 and 48h of direct exposure to each bacterial strain. Several Arabidopsis mutants with impaired responses to pathogens, impaired ethylene perception and defects in the exocyst vesicle tethering complex that is involved in secretion were also analysed. Arabidopsis seedling roots infected with Psm or Pst responded similarly to when infected with plant growth-promoting rhizobacteria; root hair growth was stimulated and primary root growth was inhibited. Other plant- and soil-adapted bacteria induced similar root hair responses. The most compromised root hair growth stimulation response was found for the knockout mutants exo70A1 and ein2. The single immune pathways dependent on salicylic acid, jasmonic acid and PAD4 are not directly involved in root hair growth stimulation; however, in the mutual cross-talk with ethylene, they indirectly modify the extent of the stimulation of root hair growth. The Flg22 peptide does not initiate root hair stimulation as intact bacteria do, but pretreatment with Flg22 prior to Psm inoculation abolished root hair growth stimulation in an FLS2 receptor kinase-dependent manner. These early response phenomena are not associated with changes in auxin levels, as monitored with the pDR5::GUS auxin reporter. Early stimulation of root hair growth is an effect of an unidentified component of living plant pathogenic bacteria. The root

  19. Frecuencia de casos de úlceras de presión y factores asociados a su desarrollo en adultos mayores hospitalizados en servicios de Medicina de un hospital general.

    Directory of Open Access Journals (Sweden)

    Carmen Eliana Peralta Vargas

    2009-01-01

    Full Text Available Objetivo: Determinar la frecuencia de casos de úlcera de presión y los factores asociados más importantes para su aparición en pacientes adultos mayores hospitalizados en el servicio de medicina de un hospital general. Material y métodos: Estudio prospectivo, observacional. Se estudiaron a todos los pacientes mayores de 60 años, hospitalizados en el servicio de medicina del Hospital Nacional Cayetano Heredia, entre diciembre de 2006 y abril de 2007. Se evaluaron diferentes variables demográficas, clínicas, así como diversos síndromes geriátricos; en dos grupos de pacientes, quienes desarrollaron úlcera de presión y los que no desarrollaron úlcera de presión. Se utilizó chi cuadrado y el análisis multivariado para determinar asociación estadística. Resultados: Se incluyeron 463 adultos mayores, la frecuencia de casos de úlcera de presión fue 11,4%. Las variables que estuvieron asociadas con el desarrollo de úlcera de presión, con una significancia estadística en el análisis univariado fueron: edad mayor de 70 años, dependencia parcial o total, deterioro cognitivo moderado o severo, incontinencia urinaria, malnutrición, riesgo moderado y alto para desarrollar úlcera de presión según escala de Norton, neumonía y accidente cerebrovascular como diagnósticos de ingreso, uso de catéter vesical, sujeción mecánica, dispositivos externos locales en zonas de prominencias óseas, la presencia de cuidador y el desarrollo de infección pulmonar intrahospitalaria. Luego del análisis multivariado solo: malnutrición (OR =6,87; IC 95%, 1,38-34,06 p=0,01 y sujeción mecánica (OR=8,09; IC 95%, 2,47-26,41 p=0,001 fueron los factores de riesgo. Conclusiones: La úlcera de presión es una condición frecuente en el adulto mayor hospitalizado. Los factores asociados a su aparición fueron malnutrición y sujeción mecánica.(Rev Med Hered 2009;20:16-21.

  20. Realistic respiratory motion margins for external beam partial breast irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Conroy, Leigh; Quirk, Sarah [Department of Medical Physics, Tom Baker Cancer Centre, Calgary, Alberta T2N 4N2 (Canada); Department of Physics and Astronomy, University of Calgary, Calgary, Alberta T2N 1N4 (Canada); Smith, Wendy L., E-mail: wendy.smith@albertahealthservices.ca [Department of Medical Physics, Tom Baker Cancer Centre, Calgary, Alberta T2N 4N2 (Canada); Department of Physics and Astronomy, University of Calgary, Calgary, Alberta T2N 1N4 (Canada); Department of Oncology, University of Calgary, Calgary, Alberta T2N 1N4 (Canada)

    2015-09-15

    Purpose: Respiratory margins for partial breast irradiation (PBI) have been largely based on geometric observations, which may overestimate the margin required for dosimetric coverage. In this study, dosimetric population-based respiratory margins and margin formulas for external beam partial breast irradiation are determined. Methods: Volunteer respiratory data and anterior–posterior (AP) dose profiles from clinical treatment plans of 28 3D conformal radiotherapy (3DCRT) PBI patient plans were used to determine population-based respiratory margins. The peak-to-peak amplitudes (A) of realistic respiratory motion data from healthy volunteers were scaled from A = 1 to 10 mm to create respiratory motion probability density functions. Dose profiles were convolved with the respiratory probability density functions to produce blurred dose profiles accounting for respiratory motion. The required margins were found by measuring the distance between the simulated treatment and original dose profiles at the 95% isodose level. Results: The symmetric dosimetric respiratory margins to cover 90%, 95%, and 100% of the simulated treatment population were 1.5, 2, and 4 mm, respectively. With patient set up at end exhale, the required margins were larger in the anterior direction than the posterior. For respiratory amplitudes less than 5 mm, the population-based margins can be expressed as a fraction of the extent of respiratory motion. The derived formulas in the anterior/posterior directions for 90%, 95%, and 100% simulated population coverage were 0.45A/0.25A, 0.50A/0.30A, and 0.70A/0.40A. The differences in formulas for different population coverage criteria demonstrate that respiratory trace shape and baseline drift characteristics affect individual respiratory margins even for the same average peak-to-peak amplitude. Conclusions: A methodology for determining population-based respiratory margins using real respiratory motion patterns and dose profiles in the AP direction was